ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A01 compound treatment 7.4510734E7 -1.17E8 -1.47 9.7467799E7 -9.94E7 -1.7 -2.2402 -0.9972 1042961 Maybridge4_000001 Clc1ccc(cc1)N2CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A02 compound treatment 9.5984834E7 -9.54E7 -1.2 1.15560703E8 -8.13E7 -1.39 -1.8307 -0.9972 3062731 Maybridge4_000002 CC(=O)NS(=O)(=O)c1ccc(/N=C/c2ccco2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A03 compound treatment 8.6170504E7 -1.05E8 -1.32 1.12483335E8 -8.44E7 -1.45 -1.955 -0.999 3062732 Maybridge4_000003 FC(F)(F)Oc1ccc(NC(=O)Nc2ccc(cc2)C3=NCCO3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A04 compound treatment 1.00783107E8 -9.06E7 -1.14 1.27466967E8 -6.94E7 -1.19 -1.644 -0.9997 1175682 Maybridge4_000004 COc1cccc2cc(C#N)c(=N)oc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A05 compound treatment 1.5720085E8 -3.42E7 -0.43 1.7080721E8 -2.61E7 -0.45 -0.619 -0.9998 3062733 Maybridge4_000005 Cc1nc(ccc1C(=O)Sc2nnc(o2)c3ccc(nc3C)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A06 compound treatment 1.74028159E8 -1.74E7 -0.22 1.87979681E8 -8920000.0 -0.15 -0.2619 -0.985 3062734 Maybridge4_000006 COc1cc(/N=C/c2cccs2)c(OC)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A07 compound treatment 1.89189654E8 -2190000.0 -0.03 1.94811103E8 -2090000.0 -0.04 -0.0447 -0.9915 3062735 Maybridge4_000007 OC1CCN(CC1)C(=O)Nc2ccc(OC(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A08 compound treatment 1.5940606E8 -3.2E7 -0.4 1.80904959E8 -1.6E7 -0.27 -0.4772 -0.9827 1676427 Maybridge4_000008 Cc1ccccc1NC(=S)Nc2cc(NS(=O)(=O)C)ccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A09 compound treatment 1.78631957E8 -1.27E7 -0.16 1.88216499E8 -8680000.0 -0.15 -0.2182 -0.9993 3179439 Maybridge4_000009 Cc1nc(ccc1NC(=O)NCCNc2cccc(n2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A10 compound treatment 1.94338698E8 2960000.0 0.04 2.01585266E8 4690000.0 0.08 0.083 0.9387 3062736 Maybridge4_000010 Cc1ccc(NC(=S)Nc2cccc(c2)C(F)(F)F)cc1NS(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A11 compound treatment 1.89019167E8 -2360000.0 -0.03 2.07067247E8 1.02E7 0.17 0.1021 0.5785 3179440 Maybridge4_000011 CC(C)(C)NC(=O)N1CCC(CC1)Nc2nccc(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A12 compound treatment 1.96501872E8 5120000.0 0.06 2.10870711E8 1.4E7 0.24 0.2145 0.8664 3062737 Maybridge4_000012 Fc1cccc(/N=C/c2ccc3OCOc3c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A13 compound treatment 1.72314618E8 -1.91E7 -0.24 1.95879353E8 -1020000.0 -0.02 -0.1815 -0.7567 3179441 Maybridge4_000013 OC(=O)c1ccccc1C(=O)NC2CCN(CC2)c3nccc(n3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A14 compound treatment 1.80417322E8 -1.1E7 -0.14 2.04784189E8 7880000.0 0.13 -0.0018 -0.0093 3062738 Maybridge4_000014 CCOC(=O)CCN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A15 compound treatment 1.78630927E8 -1.27E7 -0.16 1.95921054E8 -979000.0 -0.02 -0.1249 -0.7769 1678888 Maybridge4_000015 C(Cc1ccccc1)Nc2ncnc3scc(c4ccccc4)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A16 compound treatment 1.6160129E8 -2.98E7 -0.37 1.82836264E8 -1.41E7 -0.24 -0.4344 -0.9774 1222400 Maybridge4_000016 Oc1ccc(CCc2nnc(S)n2CCc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A17 compound treatment 1.68864141E8 -2.25E7 -0.28 1.80294661E8 -1.66E7 -0.28 -0.4007 -1.0 3179442 Maybridge4_000017 OC(=O)/C=C/C(=O)N1CCN(CC1)c2ncnc3scc(c4ccccc4)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A18 compound treatment 1.84990022E8 -6390000.0 -0.08 2.05598468E8 8700000.0 0.15 0.0486 0.2875 3179443 Maybridge4_000018 CN(C(=O)CSc1ccc(Cl)cc1)c2ccccc2C(=O)NC3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A19 compound treatment 1.84073587E8 -7310000.0 -0.09 2.08846172E8 1.19E7 0.2 0.0798 0.3561 1712315 Maybridge4_000019 COc1cccc(OC)c1C(=O)N2CCN(CC2)c3ncnc4scc(c5ccccc5)c34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A20 compound treatment 1.76963111E8 -1.44E7 -0.18 2.03058986E8 6160000.0 0.11 -0.0533 -0.2547 3179444 Maybridge4_000020 CC(C)(C)NC(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A21 compound treatment 1.81233255E8 -1.01E7 -0.13 2.19025845E8 2.21E7 0.38 0.1778 0.445 3062739 Maybridge4_000021 NC(=O)C1CCN(CC1)c2nccc(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A22 compound treatment 1.89307962E8 -2070000.0 -0.03 2.22334543E8 2.54E7 0.44 0.2895 0.6637 1149418 Maybridge4_000022 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Oc2c(C)cccc2OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A23 mock treatment 1.45919885E8 -4.55E7 -0.57 1.77523688E8 -1.94E7 -0.33 -0.6378 -0.9667 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 A24 mock treatment 1.94407539E8 3030000.0 0.04 2.04305029E8 7410000.0 0.13 0.1165 0.8804 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B01 compound treatment 2.11498375E8 2.01E7 0.25 1.41079484E8 -5.58E7 -0.96 -0.4972 -0.5031 3062740 Maybridge4_000023 CCSC1=NCN(Cc2cccs2)CN1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B02 compound treatment 2.09616595E8 1.82E7 0.23 2.07712527E8 1.08E7 0.19 0.2927 0.9945 3179445 Maybridge4_000024 Cc1ccc(CNC(=O)c2cccnc2Sc3cccc(c3)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B03 compound treatment 2.19171035E8 2.78E7 0.35 1.31909426E8 -6.5E7 -1.11 -0.5401 -0.4633 3062741 Maybridge4_000025 CN(/N=C/c1cc(Cl)cc(Cl)c1O)C(=S)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B04 compound treatment 2.10582351E8 1.92E7 0.24 2.10685327E8 1.38E7 0.24 0.3372 0.9999 3179446 Maybridge4_000026 CC(C)(C)c1ccc(cc1)c2nnc(o2)c3ccccc3NC(=O)/C=C\C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B05 compound treatment 2.17136728E8 2.58E7 0.32 2.33552548E8 3.67E7 0.63 0.6721 0.9524 3062742 Maybridge4_000027 Cc1c(C)c(C)c(CS(=O)(=O)CC(=O)Nc2ccc(F)c(Cl)c2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B06 compound treatment 1.66912235E8 -2.45E7 -0.31 1.9606797E8 -832000.0 -0.01 -0.2271 -0.7391 1435448 Maybridge4_000028 Cc1onc(c1NC(=O)Oc2ccc(CC#N)cc2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B07 compound treatment 1.95855792E8 4480000.0 0.06 1.79846505E8 -1.71E7 -0.29 -0.1667 -0.5608 1192420 Maybridge4_000029 S=C(NCCc1ccccn1)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B08 compound treatment 2.03832901E8 1.25E7 0.16 2.05021942E8 8120000.0 0.14 0.2088 0.9983 1239033 Maybridge4_000030 CSc1nnc(SC)n1CCNC(=O)Nc2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B09 compound treatment 1.94258942E8 2880000.0 0.04 2.09261363E8 1.24E7 0.21 0.1752 0.816 3179447 Maybridge4_000031 Fc1c(Br)cc(Br)c2nc(oc(=O)c12)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B10 compound treatment 1.95195518E8 3820000.0 0.05 1.54305491E8 -4.26E7 -0.73 -0.4817 -0.6593 3062743 Maybridge4_000032 Fc1ccc(Oc2ccc(NC(=O)/C=C/c3ccccc3)cn2)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B11 compound treatment 2.05053775E8 1.37E7 0.17 2.35273178E8 3.84E7 0.66 0.5858 0.8628 3179448 Maybridge4_000033 FC(F)(F)c1ccc2[nH]c(SCc3ccc(Br)cc3)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B12 compound treatment 1.85172327E8 -6210000.0 -0.08 2.06993363E8 1.01E7 0.17 0.0671 0.3542 1161087 Maybridge4_000034 Fc1ccc(cc1)n2nc3NCCCn3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B13 compound treatment 2.03709455E8 1.23E7 0.15 2.13703757E8 1.68E7 0.29 0.3128 0.9577 3062744 Maybridge4_000035 FC(F)(F)c1cccc(c1)C(=O)On2c(nc3ccccc3c2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B14 compound treatment 2.30386549E8 3.9E7 0.49 1.7656372E8 -2.03E7 -0.35 0.0999 0.1663 1279124 Maybridge4_000036 CCCCn1c(CSc2ccccn2)cn(c3nnc(s3)C(C)(C)C)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B15 compound treatment 2.08452662E8 1.71E7 0.21 2.29786569E8 3.29E7 0.56 0.5495 0.9123 1108923 Maybridge4_000037 CSC1=NC=C(C#N)C2=NC(NN21)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B16 compound treatment 1.77126168E8 -1.43E7 -0.18 1.5221215E8 -4.47E7 -0.76 -0.6673 -0.8495 1163777 Maybridge4_000038 CC(C)(C)c1cc(cc(c1)C(=O)Oc2cncc(Cl)c2)C(=O)Oc3cncc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B17 compound treatment 1.77020296E8 -1.44E7 -0.18 2.02142777E8 5240000.0 0.09 -0.0639 -0.3175 1150645 Maybridge4_000039 Cc1cc(NS(=O)(=O)c2ccc(F)c(Cl)c2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B18 compound treatment 2.15817096E8 2.44E7 0.31 2.10526865E8 1.36E7 0.23 0.3817 0.9909 3179449 Maybridge4_000040 CSc1ncccc1C2=N/C(=C\N(C)C)/C(=O)O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B19 compound treatment 2.01710783E8 1.03E7 0.13 2.07767583E8 1.09E7 0.19 0.2232 0.9844 3062745 Maybridge4_000041 CN(C)/C=N/c1nnc(SCC(=O)c2ccc(F)cc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B20 compound treatment 2.05123037E8 1.37E7 0.17 2.16317462E8 1.94E7 0.33 0.357 0.9533 3179558 Maybridge4_000042 COC(=O)/C(=C/1\NC(=NC(=C1C#N)SC)C)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B21 compound treatment 1.96688368E8 5310000.0 0.07 2.15819849E8 1.89E7 0.32 0.2761 0.8351 3179559 Maybridge4_000043 CN(C)/C=N/c1nnc(Sc2cc(C)nc3ccccc23)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B22 compound treatment 1.93083944E8 1710000.0 0.02 2.4225976E8 4.54E7 0.78 0.5642 0.7263 3062746 Maybridge4_000044 CCOC(=O)c1c(C)c(C#N)c(/N=C/N(C)C)n1c2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B23 mock treatment 1.86730724E8 -4650000.0 -0.06 2.05857174E8 8960000.0 0.15 0.0672 0.4096 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 B24 mock treatment 1.89773698E8 -1610000.0 -0.02 2.06040434E8 9140000.0 0.16 0.0964 0.6111 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C01 compound treatment 8.0233293E7 -1.11E8 -1.39 1.00448999E8 -9.65E7 -1.65 -2.1534 -0.9965 1040601 Maybridge4_000045 COc1cccc(c1)N2CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C02 compound treatment 8.9519668E7 -1.02E8 -1.28 1.17258313E8 -7.96E7 -1.36 -1.8675 -0.9995 3062747 Maybridge4_000046 COc1cc(/C=N/N)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C03 compound treatment 8.3661496E7 -1.08E8 -1.35 1.17587377E8 -7.93E7 -1.36 -1.9155 -1.0 3179560 Maybridge4_000047 FC(F)(F)c1cccnc1N2CCNC2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C04 compound treatment 1.15095895E8 -7.63E7 -0.96 1.46496017E8 -5.04E7 -0.86 -1.2868 -0.9987 1723231 Maybridge4_000048 Clc1c(sc2ccccc12)C(=O)N(Cc3ccccc3)C(C#N)c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C05 compound treatment 1.29930184E8 -6.14E7 -0.77 1.78249318E8 -1.87E7 -0.32 -0.7708 -0.9239 3062748 Maybridge4_000049 Cc1ccc(NC(=S)N2CCCN(CC2)c3ncc(cc3Cl)C(F)(F)F)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C06 compound treatment 1.39219115E8 -5.22E7 -0.65 1.60245063E8 -3.67E7 -0.63 -0.9064 -0.9998 1322626 Maybridge4_000050 Fc1ccc(cc1)N(Cc2ccc3OCOc3c2)S(=O)(=O)c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C07 compound treatment 1.72509608E8 -1.89E7 -0.24 2.00148459E8 3250000.0 0.06 -0.1281 -0.5266 1288233 Maybridge4_000051 CCOC(=O)c1cc(C(=O)OC)c(C)nc1N2CCCN(Cc3ccc(F)cc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C08 compound treatment 1.70464572E8 -2.09E7 -0.26 1.88600927E8 -8300000.0 -0.14 -0.286 -0.9585 3179561 Maybridge4_000052 CCOC(=O)/C(=C(/C)\N)/C1CC(=O)N(C1=O)c2ccc(cc2)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C09 compound treatment 1.73677884E8 -1.77E7 -0.22 1.86268738E8 -1.06E7 -0.18 -0.2857 -0.9951 1354107 Maybridge4_000053 OC(COc1ccc(Br)cc1)CN2CCCN(CC2)c3nc4ccc(Cl)cc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C10 compound treatment 1.68816364E8 -2.26E7 -0.28 1.87247938E8 -9650000.0 -0.17 -0.317 -0.9672 1692586 Maybridge4_000054 Cc1ccc(cc1)S(=O)(=O)N(c2nc3ccccc3s2)c4cccc(Cl)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C11 compound treatment 1.89253138E8 -2130000.0 -0.03 2.02757263E8 5860000.0 0.1 0.052 0.5016 1369581 Maybridge4_000055 CC(C)(C)OC(=O)N1CCCN(CC1)C(=O)Nc2ccc(F)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C12 compound treatment 1.93456157E8 2080000.0 0.03 1.99946404E8 3050000.0 0.05 0.0553 0.9486 1212228 Maybridge4_000056 Cc1ccc(c(NC(=O)C(C2CCCC2)c3ccccc3)c1)n4cccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C13 compound treatment 2.13433696E8 2.21E7 0.28 2.31963753E8 3.51E7 0.6 0.6201 0.9382 3179562 Maybridge4_000057 Cc1nc(ccc1C(=O)NCC2CC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C14 compound treatment 2.10400093E8 1.9E7 0.24 2.00778325E8 3880000.0 0.07 0.2157 0.8708 1629863 Maybridge4_000058 Oc1c(Cl)cc(Cl)cc1C2Nc3cccc4cccc(N2)c34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C15 compound treatment 2.10926023E8 1.95E7 0.25 2.19664622E8 2.28E7 0.39 0.4489 0.9751 3062749 Maybridge4_000059 CCCNC(=O)NC1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C16 compound treatment 2.6945266E8 7.81E7 0.98 2.64550127E8 6.77E7 1.16 1.5114 0.9965 1569566 Maybridge4_000060 CC(c1ccccc1)n2c(S)nnc2CCc3ccc(O)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C17 compound treatment 1.97421159E8 6040000.0 0.08 2.12454002E8 1.56E7 0.27 0.2419 0.8737 1204274 Maybridge4_000061 Fc1cccc(Cl)c1CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C18 compound treatment 2.10356736E8 1.9E7 0.24 2.1847651E8 2.16E7 0.37 0.4295 0.9774 1455358 Maybridge4_000062 O=C(Nc1nccc2ccccc12)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C19 compound treatment 2.00561515E8 9180000.0 0.12 2.04199097E8 7300000.0 0.12 0.1698 0.9992 3179563 Maybridge4_000063 COc1cccc(CC(=O)NC2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C20 compound treatment 2.09094583E8 1.77E7 0.22 2.18478392E8 2.16E7 0.37 0.4183 0.9704 3062750 Maybridge4_000064 CC(C)(C)NC(=S)Nc1ccccc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C21 compound treatment 1.86223081E8 -5160000.0 -0.06 1.97873128E8 973000.0 0.02 -0.034 -0.5084 1137780 Maybridge4_000065 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c2ccc(Oc3cccnc3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C22 compound treatment 1.97872814E8 6490000.0 0.08 2.06696414E8 9800000.0 0.17 0.1762 0.945 3179564 Maybridge4_000066 FC(F)(F)c1cc(NCC(=O)c2cc3cc(Cl)ccc3o2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C23 mock treatment 1.89865001E8 -1510000.0 -0.02 2.23811491E8 2.69E7 0.46 0.3123 0.6774 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 C24 mock treatment 1.9606638E8 4690000.0 0.06 1.98944193E8 2040000.0 0.03 0.0663 0.9693 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D01 compound treatment 2.04692673E8 1.33E7 0.17 2.05471937E8 8570000.0 0.15 0.2219 0.9979 3179565 Maybridge4_000067 Cc1nn(nc1C(=O)Oc2c(Cl)cccc2Cl)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D02 compound treatment 2.00613519E8 9230000.0 0.12 2.20850659E8 2.4E7 0.41 0.3718 0.8727 3062751 Maybridge4_000068 COc1cc(cc(Br)c1OC(=O)NC(=O)c2c(F)cccc2F)C3SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D03 compound treatment 1.77235603E8 -1.41E7 -0.18 2.05180691E8 8280000.0 0.14 -0.0252 -0.1111 1545199 Maybridge4_000069 CCOC(=O)c1cnc2cc(Cl)c(F)cc2c1N3CC(C)OC(C)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D04 compound treatment 2.04322147E8 1.29E7 0.16 2.18363454E8 2.15E7 0.37 0.3746 0.9326 1652603 Maybridge4_000070 CC(C)(C)c1ccc(cc1)c2nnc(o2)c3ccccc3NC(=O)CCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D05 compound treatment 1.63596917E8 -2.78E7 -0.35 2.110737E8 1.42E7 0.24 -0.0749 -0.1763 1338281 Maybridge4_000071 Clc1ccccc1C(=O)NC(=O)NC2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D06 compound treatment 1.51372903E8 -4.0E7 -0.5 1.65438807E8 -3.15E7 -0.54 -0.7357 -0.9994 1457562 Maybridge4_000072 OC(=O)C(CCC(=O)Nc1ccc2OCOCc2c1)N3C(=O)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D07 compound treatment 1.82278155E8 -9100000.0 -0.11 2.00019362E8 3120000.0 0.05 -0.043 -0.3409 3062752 Maybridge4_000073 CC1CN(CC(C)O1)C2=NCCN2S(=O)(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D08 compound treatment 1.7287941E8 -1.85E7 -0.23 1.8170153E8 -1.52E7 -0.26 -0.3481 -0.9984 3179566 Maybridge4_000074 Cc1nn(nc1C(=O)c2c(O)n(nc2C(C)(C)C)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D09 compound treatment 2.0431688E8 1.29E7 0.16 2.21247058E8 2.43E7 0.42 0.4095 0.9155 3062753 Maybridge4_000075 Cc1cc(Br)c(c(Br)c1Cl)n2cccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D10 compound treatment 1.95885746E8 4510000.0 0.06 2.4516057E8 4.83E7 0.83 0.6241 0.7537 3179567 Maybridge4_000076 Fc1ccc(Oc2ncccc2NC(=O)/C=C/c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D11 compound treatment 2.14233197E8 2.29E7 0.29 2.35404784E8 3.85E7 0.66 0.6688 0.9305 3062754 Maybridge4_000077 CC(C)(C)c1cs/c(=N/c2ccccn2)/n1c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D12 compound treatment 1.61825922E8 -2.96E7 -0.37 1.71830427E8 -2.51E7 -0.43 -0.5656 -0.9973 1415138 Maybridge4_000078 CN1C(C(=O)N(C1=O)c2nnc(s2)C(C)(C)C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D13 compound treatment 2.19554651E8 2.82E7 0.35 1.93297643E8 -3600000.0 -0.06 0.2063 0.5751 3063175 Maybridge4_000079 CC(C)(C)c1csc(Cc2ccccc2Cl)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D14 compound treatment 1.64407873E8 -2.7E7 -0.34 1.89148641E8 -7750000.0 -0.13 -0.3331 -0.9165 3179568 Maybridge4_000080 Fc1ccc(NC(=O)CSc2nnc(NC(=O)c3ccc(Cl)c(Cl)c3)s2)c(F)c1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D15 compound treatment 1.9516513E8 3790000.0 0.05 2.0533783E8 8440000.0 0.14 0.1357 0.8926 1691601 Maybridge4_000081 CS(=O)(=O)Nc1ccc2oc3ncccc3c(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D16 compound treatment 1.68555491E8 -2.28E7 -0.29 1.7563157E8 -2.13E7 -0.36 -0.4599 -0.9929 1489888 Maybridge4_000082 CC(C)(C)c1cc(cc(c1)C(=O)NCc2cccs2)C(=O)NCc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D17 compound treatment 1.75262286E8 -1.61E7 -0.2 1.58620514E8 -3.83E7 -0.66 -0.6063 -0.8841 3063176 Maybridge4_000083 Clc1ccc(cc1Cl)C(=O)c2nn3c(nc(=O)c4ccccc43)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D18 compound treatment 1.9945216E8 8070000.0 0.1 2.21208112E8 2.43E7 0.42 0.3658 0.8543 3179569 Maybridge4_000084 CN(C)/C=C/1\N=C(OC1=O)c2cccnc2Oc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D19 compound treatment 2.13847855E8 2.25E7 0.28 2.12468889E8 1.56E7 0.27 0.3878 0.9996 1342823 Maybridge4_000085 Fc1ccc(c(F)c1)S(=O)(=O)Nc2ccccc2C(=O)NCC3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D20 compound treatment 1.73111199E8 -1.83E7 -0.23 1.93481898E8 -3420000.0 -0.06 -0.2034 -0.8601 3063177 Maybridge4_000086 CC(C)(C(=O)Nc1cccc(Cl)c1)S(=O)(=O)c2ccc(cn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D21 compound treatment 1.97953122E8 6570000.0 0.08 2.23784704E8 2.69E7 0.46 0.3837 0.8207 3063178 Maybridge4_000087 CC1=NN(C(=O)CC1)c2cc(Cl)cc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D22 compound treatment 1.70275055E8 -2.11E7 -0.26 1.8430424E8 -1.26E7 -0.22 -0.3397 -0.9948 1609394 Maybridge4_000088 CCOC(=O)c1c(C)c(C#N)c(N(C(=O)C)C(=O)C)n1c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D23 mock treatment 1.73758687E8 -1.76E7 -0.22 1.93195988E8 -3700000.0 -0.06 -0.2011 -0.8747 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 D24 mock treatment 1.95356823E8 3980000.0 0.05 1.93092916E8 -3810000.0 -0.07 -0.0108 -0.1315 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E01 compound treatment 1.40227337E8 -5.12E7 -0.64 1.3440702E8 -6.25E7 -1.07 -1.2102 -0.9701 1042964 Maybridge4_000089 Cc1cccc(c1)N2CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E02 compound treatment 1.53103874E8 -3.83E7 -0.48 1.59107983E8 -3.78E7 -0.65 -0.797 -0.9892 1679137 Maybridge4_000090 NNC(=O)C1CCCNC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E03 compound treatment 1.45109257E8 -4.63E7 -0.58 1.44193103E8 -5.27E7 -0.9 -1.0484 -0.9772 1296373 Maybridge4_000091 CC(C)(C)OC(=O)N1CCCN(CC1)S(=O)(=O)c2cc(Cl)ccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E04 compound treatment 1.92737587E8 1360000.0 0.02 2.00462152E8 3560000.0 0.06 0.0552 0.8714 1584716 Maybridge4_000092 COc1cc(cc(OC)c1OC)C(=O)NC(=S)NC(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E05 compound treatment 2.0609603E8 1.47E7 0.18 2.18883578E8 2.2E7 0.38 0.3966 0.9463 3063179 Maybridge4_000093 CSc1nnc(o1)c2ccc(nc2C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E06 compound treatment 2.37543735E8 4.62E7 0.58 2.28947014E8 3.2E7 0.55 0.7974 0.9996 3179570 Maybridge4_000094 Cc1onc(c1C(=O)NC(=S)Nc2ccc(Cl)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E07 compound treatment 2.46181214E8 5.48E7 0.69 2.64012379E8 6.71E7 1.15 1.2985 0.9699 1200576 Maybridge4_000095 CCOC(=O)c1cc(C(=O)OC)c(C)nc1SCC(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E08 compound treatment 2.3233329E8 4.1E7 0.51 2.29460178E8 3.26E7 0.56 0.7574 0.9992 1402318 Maybridge4_000096 CCOC(=O)C1=C(C)NC(=O)C1CC(=O)Nc2ccc(cc2)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E09 compound treatment 2.42568786E8 5.12E7 0.64 2.33771575E8 3.69E7 0.63 0.9004 1.0 1736057 Maybridge4_000097 CCOC(=O)c1cc(C#N)c(C)nc1N2CCN(CC2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E10 compound treatment 2.55351268E8 6.4E7 0.8 2.23218924E8 2.63E7 0.45 0.886 0.9627 1619754 Maybridge4_000098 CC(=O)Nc1ccc(C)c(NC(=S)Nc2ccc(Cl)c(Cl)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E11 compound treatment 2.43270042E8 5.19E7 0.65 2.54687797E8 5.78E7 0.99 1.1598 0.9794 1175297 Maybridge4_000099 O=C1CC2(CCCC2)C(=O)N1CCc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E12 compound treatment 2.53482126E8 6.21E7 0.78 2.64515282E8 6.76E7 1.16 1.3693 0.9814 3179665 Maybridge4_000100 COc1cc(NC(=O)C(C2CCCC2)c3ccccc3)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E13 compound treatment 2.31695782E8 4.03E7 0.51 2.45687916E8 4.88E7 0.84 0.9482 0.9711 1528875 Maybridge4_000101 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccc(s3)c4csc(C)n4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E14 compound treatment 2.44482649E8 5.31E7 0.67 2.63500293E8 6.66E7 1.14 1.2772 0.9673 1511104 Maybridge4_000102 CN(C)c1ccc(cc1)C2N(Cc3ccccc3)CCC4CCCCN24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E15 compound treatment 2.3768333E8 4.63E7 0.58 2.58477518E8 6.16E7 1.05 1.1561 0.9606 3063180 Maybridge4_000103 FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)c3nccc(n3)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E16 compound treatment 2.5297727E8 6.16E7 0.77 2.57111003E8 6.02E7 1.03 1.2752 0.9899 3179666 Maybridge4_000104 C/C(=N\C(=O)NN)/c1cnn(c1C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E17 compound treatment 2.52939986E8 6.16E7 0.77 2.32765956E8 3.59E7 0.61 0.9802 0.9935 3179667 Maybridge4_000105 C(CNc1ncnc2scc(c3ccccc3)c12)Cn4ccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E18 compound treatment 2.36883232E8 4.55E7 0.57 2.48881476E8 5.2E7 0.89 1.0328 0.977 1369305 Maybridge4_000106 CCN1CCCC1CN2CNC(=S)NC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E19 compound treatment 2.41975245E8 5.06E7 0.63 2.41696143E8 4.48E7 0.77 0.991 0.9956 3179668 Maybridge4_000107 FC(F)(F)c1ccnc(n1)N2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E20 compound treatment 2.44695453E8 5.33E7 0.67 2.34355954E8 3.75E7 0.64 0.9263 0.9998 3063181 Maybridge4_000108 CSc1cccc(NC(=S)NC(C)(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E21 compound treatment 2.45705852E8 5.43E7 0.68 2.25312283E8 2.84E7 0.49 0.8258 0.9863 1338166 Maybridge4_000109 Cc1cnc(N2CCN(CC2)NC(=S)Nc3cccnc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E22 compound treatment 2.68961862E8 7.76E7 0.97 2.37830208E8 4.09E7 0.7 1.1836 0.987 1138152 Maybridge4_000110 COc1ccc(NC(=S)NC(C)(C)C)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E23 mock treatment 1.96994848E8 5620000.0 0.07 1.83255909E8 -1.36E7 -0.23 -0.1153 -0.4728 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 E24 mock treatment 2.14633775E8 2.33E7 0.29 2.05318094E8 8420000.0 0.14 0.3082 0.9471 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F01 compound treatment 2.35503206E8 4.41E7 0.55 2.57840776E8 6.09E7 1.04 1.129 0.9561 1442676 Maybridge4_000111 Fc1cccc(Cl)c1C(=O)NC(=O)N2CCSC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F02 compound treatment 1.9259721E8 1220000.0 0.02 1.83060925E8 -1.38E7 -0.24 -0.1567 -0.6601 3179669 Maybridge4_000112 CN(C)/C(=N/c1nnc(Sc2nc3cc(Cl)ccc3s2)s1)/C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F03 compound treatment 2.64546572E8 7.32E7 0.92 2.65194311E8 6.83E7 1.17 1.4757 0.9928 3179670 Maybridge4_000113 Fc1ccc(NC(=O)NCSCc2cccc(c2)C(F)(F)F)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F04 compound treatment 2.43263338E8 5.19E7 0.65 1.6115677E8 -3.57E7 -0.61 0.0276 0.0309 1189445 Maybridge4_000114 COc1cccc(c1)c2nnc(o2)c3ccccc3NS(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F05 compound treatment 2.36070146E8 4.47E7 0.56 2.58412381E8 6.15E7 1.05 1.141 0.9565 3179671 Maybridge4_000115 FC(F)(F)c1cccc(c1)C(=O)NC2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F06 compound treatment 2.26018904E8 3.46E7 0.43 2.29082515E8 3.22E7 0.55 0.6968 0.9931 1529642 Maybridge4_000116 Cc1cc2ncc(nc2cc1C)c3ccn(c3)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F07 compound treatment 1.77365055E8 -1.4E7 -0.18 2.20046859E8 2.31E7 0.4 0.1559 0.3596 1440337 Maybridge4_000117 Clc1cccc(Cl)c1C(=O)NC2CCS(=O)(=O)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F08 compound treatment 2.37158103E8 4.58E7 0.57 2.44295838E8 4.74E7 0.81 0.9798 0.9857 1688196 Maybridge4_000118 COc1ccc(Cl)c(OC)c1C(=O)NC(=O)Nc2c(C)cccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F09 compound treatment 2.40635596E8 4.93E7 0.62 2.49526909E8 5.26E7 0.9 1.0739 0.9831 3063182 Maybridge4_000119 COC(=O)/C=C/1\S/C(=N\c2ccc(C)c(C)c2)/N(C1=O)c3ccc(C)c(C)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F10 compound treatment 2.33741806E8 4.24E7 0.53 2.64881786E8 6.8E7 1.16 1.1986 0.9369 3179672 Maybridge4_000120 NNC(=O)CS(=O)(=O)c1ccc(cn1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F11 compound treatment 2.6115027E8 6.98E7 0.88 2.4536056E8 4.85E7 0.83 1.2055 0.9996 3179673 Maybridge4_000121 Cc1ncc(CSc2nc3cc(ccc3[nH]2)C(F)(F)F)c(CO)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F12 compound treatment 2.23149052E8 3.18E7 0.4 2.22162465E8 2.53E7 0.43 0.5876 0.9992 1621608 Maybridge4_000122 Cc1cc(cc(C)c1O)c2nn(C)c(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F13 compound treatment 2.42159419E8 5.08E7 0.64 1.88509695E8 -8390000.0 -0.14 0.3489 0.5343 1331054 Maybridge4_000123 CC(C)c1cccc(C(C)C)c1OC(=O)NC(=O)c2c(F)cccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F14 compound treatment 2.32834407E8 4.15E7 0.52 2.53566855E8 5.67E7 0.97 1.0536 0.9573 3063183 Maybridge4_000124 FC(F)(F)c1nnc(NC(=O)Nc2ccccc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F15 compound treatment 1.72091097E8 -1.93E7 -0.24 2.80321082E8 8.34E7 1.43 0.8387 0.579 3179674 Maybridge4_000125 COc1cc2c(=O)oc(nc2c(OC)c1OC)c3c(C)onc3c4c(F)cccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F16 compound treatment 2.19219319E8 2.78E7 0.35 2.19508829E8 2.26E7 0.39 0.5206 0.9987 3063184 Maybridge4_000126 Brc1ccc(s1)c2cnc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F17 compound treatment 2.4935372E8 5.8E7 0.73 2.48478122E8 5.16E7 0.88 1.1386 0.9954 1216365 Maybridge4_000127 Clc1ccc(Oc2nc(Oc3ccc(Cl)cc3)nc(n2)N4CCSCC4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F18 compound treatment 2.27165756E8 3.58E7 0.45 2.14952838E8 1.81E7 0.31 0.536 0.9834 1464435 Maybridge4_000128 CC(C)(C)c1ccc(Oc2ncccc2C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F19 compound treatment 2.38614103E8 4.72E7 0.59 2.45215582E8 4.83E7 0.83 1.0038 0.9866 1281583 Maybridge4_000129 Cc1nn(nc1C(=O)NC(=O)N2CCSCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F20 compound treatment 2.52165351E8 6.08E7 0.76 2.55116424E8 5.82E7 1.0 1.2439 0.9913 3063185 Maybridge4_000130 CC(C)(C(=O)Oc1ccccc1)S(=O)(=O)c2ccc(cn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F21 compound treatment 2.5140179E8 6.0E7 0.75 2.37195549E8 4.03E7 0.69 1.0202 0.999 3179675 Maybridge4_000131 CC(C)(C)SCCNc1nc(Sc2ccc(Cl)cc2)nc(n1)N3CCSCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F22 compound treatment 2.32762325E8 4.14E7 0.52 2.35492352E8 3.86E7 0.66 0.8342 0.9929 3063186 Maybridge4_000132 CSc1nn(C)c2cnn(C)c(=O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F23 mock treatment 2.43828266E8 5.24E7 0.66 2.30611109E8 3.37E7 0.58 0.8733 0.9979 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 F24 mock treatment 2.16573829E8 2.52E7 0.32 2.24631782E8 2.77E7 0.47 0.5592 0.9805 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G01 compound treatment 1.03256438E8 -8.81E7 -1.11 1.12898762E8 -8.4E7 -1.44 -1.7984 -0.9916 3063187 Maybridge4_000133 Cc1ccccc1N2CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G02 compound treatment 1.16959494E8 -7.44E7 -0.93 1.30397104E8 -6.65E7 -1.14 -1.4651 -0.9951 3179676 Maybridge4_000134 c1ccc(nc1)c2nnc([nH]2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G03 compound treatment 9.0640001E7 -1.01E8 -1.26 9.5908129E7 -1.01E8 -1.73 -2.116 -0.9881 1229940 Maybridge4_000135 OC(CNCc1ccc(Cl)cc1Cl)Cn2c(cc3ccccc23)c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G04 compound treatment 1.37097422E8 -5.43E7 -0.68 1.58906351E8 -3.8E7 -0.65 -0.9414 -0.9997 3063224 Maybridge4_000136 NC(=O)NC(=S)NC(=O)c1ccccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G05 compound treatment 1.91297473E8 -81300.0 0.0 2.10939408E8 1.4E7 0.24 0.1692 0.7041 3063225 Maybridge4_000137 FC(F)(F)c1cccc(NC(=S)NCCNc2nccc(n2)C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G06 compound treatment 2.12554073E8 2.12E7 0.27 2.21929446E8 2.5E7 0.43 0.4908 0.9736 1407734 Maybridge4_000138 Cc1cccc(C)c1NC(=S)N2CCCc3cccc(C)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G07 compound treatment 2.18594237E8 2.72E7 0.34 2.25873278E8 2.9E7 0.5 0.5921 0.9834 3063226 Maybridge4_000139 Cc1nc(ccc1C(=O)O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G08 compound treatment 2.15235186E8 2.39E7 0.3 2.32515141E8 3.56E7 0.61 0.6427 0.9463 3063227 Maybridge4_000140 CC(C)N(Cc1ccc(cc1)N(C)C)S(=O)(=O)c2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G09 compound treatment 2.05406345E8 1.4E7 0.18 2.22756242E8 2.59E7 0.44 0.4374 0.9183 1525364 Maybridge4_000141 COc1ccccc1NC(=O)N2CCCN(Cc3ccc(F)cc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G10 compound treatment 2.14734299E8 2.34E7 0.29 2.2176765E8 2.49E7 0.43 0.5082 0.9834 3179677 Maybridge4_000142 Cc1cccc2c(=O)n(CCNCc3ccccc3)c(C)nc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G11 compound treatment 2.12971077E8 2.16E7 0.27 2.2478325E8 2.79E7 0.48 0.529 0.964 1397176 Maybridge4_000143 Cc1cc(c(C)cc1Cl)S(=O)(=O)N2CCCN(CC2)c3nc4ccc(Cl)cc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G12 compound treatment 2.11934624E8 2.06E7 0.26 2.21297202E8 2.44E7 0.42 0.4776 0.9732 1223333 Maybridge4_000144 COc1cc2CCN=C(c3c(C)onc3c4ccccc4)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G13 compound treatment 2.03969432E8 1.26E7 0.16 2.28077571E8 3.12E7 0.53 0.4891 0.8787 3179678 Maybridge4_000145 Clc1ccc(cc1)S(=O)(=O)NCCNc2ncnc3scc(c4ccccc4)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G14 compound treatment 2.2283587E8 3.15E7 0.39 2.28169948E8 3.13E7 0.54 0.6575 0.9888 3063228 Maybridge4_000146 FC(F)(F)c1cc(NC(=O)CSC(=O)c2ccco2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G15 compound treatment 2.15255374E8 2.39E7 0.3 2.14789293E8 1.79E7 0.31 0.4283 0.9999 1479980 Maybridge4_000147 COc1cccc(OC)c1C(=O)N2CCCN(CC2)c3nc4ccc(Cl)cc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G16 compound treatment 2.29125965E8 3.77E7 0.47 2.32289129E8 3.54E7 0.61 0.7632 0.9926 3063229 Maybridge4_000148 FC(F)(F)c1cccc(c1)N2CCNC2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G17 compound treatment 2.22158367E8 3.08E7 0.39 2.51254254E8 5.44E7 0.93 0.9309 0.9241 1615569 Maybridge4_000149 Ic1ccc(cc1)N2C(=O)CC3(CCCC3)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G18 compound treatment 2.1204533E8 2.07E7 0.26 2.16294222E8 1.94E7 0.33 0.4181 0.9925 3063230 Maybridge4_000150 FC(F)(F)c1cc(Br)ccc1/N=C/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G19 compound treatment 2.06559908E8 1.52E7 0.19 2.22440067E8 2.55E7 0.44 0.4438 0.9307 3179679 Maybridge4_000151 Fc1cccc(Cl)c1CN2CCN(CCCNC(=O)c3cccc(c3)C(F)(F)F)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G20 compound treatment 2.31381532E8 4.0E7 0.5 2.34855084E8 3.8E7 0.65 0.8143 0.9919 3063231 Maybridge4_000152 Cc1ccc(NC(=S)NC(C)(C)C)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G21 compound treatment 2.12902511E8 2.15E7 0.27 2.16529194E8 1.96E7 0.34 0.4285 0.9941 3179680 Maybridge4_000153 CSc1cccc(NC(=O)/C=C/c2ccc(cc2)C(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G22 compound treatment 2.30012275E8 3.86E7 0.48 2.30916516E8 3.4E7 0.58 0.7544 0.9958 3063232 Maybridge4_000154 S=C1NCN(Cc2cccs2)CN1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G23 mock treatment 2.08108014E8 1.67E7 0.21 2.18141492E8 2.12E7 0.36 0.4055 0.9659 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 G24 mock treatment 2.13213365E8 2.18E7 0.27 2.12121857E8 1.52E7 0.26 0.3779 0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H01 compound treatment 2.22738374E8 3.14E7 0.39 2.2961001E8 3.27E7 0.56 0.6741 0.9851 3179681 Maybridge4_000155 Cc1ccc(SCc2ccccc2c3nc4ccccc4[nH]3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H02 compound treatment 2.25733177E8 3.44E7 0.43 2.42061609E8 4.52E7 0.77 0.8514 0.9619 3063233 Maybridge4_000156 CN(C)/C=N/c1nnc(SCC(=O)Nc2cc(Cl)cc(Cl)c2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H03 compound treatment 2.40205414E8 4.88E7 0.61 2.46588914E8 4.97E7 0.85 1.0346 0.987 3179769 Maybridge4_000157 CCC(C)n1c(=O)[nH][nH]c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H04 compound treatment 2.16003509E8 2.46E7 0.31 2.23577647E8 2.67E7 0.46 0.5413 0.9819 1039773 Maybridge4_000158 Cc1ccc(=O)n(Cc2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H05 compound treatment 2.40232823E8 4.89E7 0.61 2.44698166E8 4.78E7 0.82 1.0119 0.9899 3179770 Maybridge4_000159 Fc1cccc(CSC2=NCN(CN2)C3CC3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H06 compound treatment 1.83662659E8 -7720000.0 -0.1 1.98328159E8 1430000.0 0.02 -0.0512 -0.5124 3063234 Maybridge4_000160 FC(F)(F)c1cc(COc2ccc(CC#N)cc2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H07 compound treatment 2.27927872E8 3.65E7 0.46 2.33336807E8 3.64E7 0.62 0.7652 0.9885 1661120 Maybridge4_000161 COc1ccc(OC)c(c1)S(=O)(=O)NC2CCS(=O)(=O)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H08 compound treatment 2.25226303E8 3.38E7 0.42 2.32446512E8 3.55E7 0.61 0.7305 0.9845 3063235 Maybridge4_000162 CN(C)/C=N/c1ccc(Oc2cncc(Cl)c2)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H09 compound treatment 2.22409163E8 3.1E7 0.39 2.31408707E8 3.45E7 0.59 0.693 0.9795 3179771 Maybridge4_000163 Fc1ccc2sc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H10 compound treatment 1.67744343E8 -2.36E7 -0.3 1.83916974E8 -1.3E7 -0.22 -0.3668 -0.9899 3063236 Maybridge4_000164 CC(=C)C(=O)Nc1ccc(Oc2ccccc2F)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H11 compound treatment 2.35197248E8 4.38E7 0.55 2.43869251E8 4.7E7 0.8 0.9572 0.9828 3179772 Maybridge4_000165 Cc1cc(ccc1Cl)C2(O)CSc3nc4cc(ccc4n32)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H12 compound treatment 2.17057463E8 2.57E7 0.32 2.2379395E8 2.69E7 0.46 0.5533 0.9847 1316383 Maybridge4_000166 Cc1ccc(cc1)C(=O)Oc2c(C)cc(cc2C)c3nn(C)c(=O)c4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H13 compound treatment 2.24345052E8 3.3E7 0.41 2.36671189E8 3.98E7 0.68 0.7738 0.9715 1008407 Maybridge4_000167 Clc1ccc(OCOc2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H14 compound treatment 1.97047781E8 5670000.0 0.07 2.1018578E8 1.33E7 0.23 0.2111 0.8859 3179773 Maybridge4_000168 CN(C)/C=C(\Sc1nnc(N)s1)/C(=O)Nc2ccc(F)c(F)c2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H15 compound treatment 2.36028644E8 4.46E7 0.56 2.36826558E8 3.99E7 0.68 0.8793 0.9951 3063237 Maybridge4_000169 O=c1ncn(Cc2cccs2)cc1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H16 compound treatment 2.20819969E8 2.94E7 0.37 2.27966939E8 3.11E7 0.53 0.6372 0.9841 1639465 Maybridge4_000170 COC(=O)CNC(=O)c1cccnc1Sc2cc(OC)ccc2OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H17 compound treatment 2.37008608E8 4.56E7 0.57 2.31599819E8 3.47E7 0.59 0.8248 0.9998 3063238 Maybridge4_000171 CCOC(=O)c1cc(CC)sc1NC(=S)Nc2ccccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H18 compound treatment 2.31198738E8 3.98E7 0.5 2.16204802E8 1.93E7 0.33 0.5869 0.9799 1639248 Maybridge4_000172 CN(N1CC(C)(C)C1=O)c2cnn(c3ccc(C)cc3)c(=O)c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H19 compound treatment 2.26443886E8 3.51E7 0.44 2.31819266E8 3.49E7 0.6 0.7337 0.9886 1494290 Maybridge4_000173 CC1CN(CC(C)O1)C(=O)NC(=O)c2nn(nc2C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H20 compound treatment 2.13305051E8 2.19E7 0.28 2.29367872E8 3.25E7 0.56 0.5875 0.9474 3179774 Maybridge4_000174 Cc1ccc(/C=C/c2onc3c(=O)[nH]nc(C)c23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H21 compound treatment 2.21181432E8 2.98E7 0.37 2.29519077E8 3.26E7 0.56 0.6592 0.981 3179775 Maybridge4_000175 Cc1cc(=O)oc2[nH]nc(CSc3ccc(Cl)cc3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H22 compound treatment 2.1861932E8 2.72E7 0.34 2.27203811E8 3.03E7 0.52 0.6084 0.9795 1137912 Maybridge4_000176 CCOC(=O)c1c(C)c(C#N)c(NC(=O)c2ccc(Cl)cc2Cl)n1c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H23 mock treatment 2.21899608E8 3.05E7 0.38 2.33268119E8 3.64E7 0.62 0.7109 0.9727 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 H24 mock treatment 2.07281794E8 1.59E7 0.2 2.06675993E8 9780000.0 0.17 0.2594 0.9962 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I01 compound treatment 1.26128991E8 -6.52E7 -0.82 1.25393961E8 -7.15E7 -1.22 -1.4443 -0.9809 3179776 Maybridge4_000177 OC(=O)C1CCc2ccccc2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I02 compound treatment 1.38450428E8 -5.29E7 -0.66 1.34552012E8 -6.23E7 -1.07 -1.2242 -0.9739 1265650 Maybridge4_000178 OC(=O)c1ccccc1NC(=O)c2ccccc2NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I03 compound treatment 1.37614342E8 -5.38E7 -0.67 1.2283929E8 -7.41E7 -1.27 -1.3734 -0.9564 3063239 Maybridge4_000179 COc1ccc(CC/N=C/c2ccc(Oc3nccc(n3)C(F)(F)F)cc2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I04 compound treatment 1.74965127E8 -1.64E7 -0.21 1.57580052E8 -3.93E7 -0.67 -0.6215 -0.883 3179777 Maybridge4_000180 Cc1ccc(Nc2nc3ccccc3s2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I05 compound treatment 1.66302715E8 -2.51E7 -0.31 1.49637528E8 -4.73E7 -0.81 -0.7945 -0.9153 3179778 Maybridge4_000181 FC(F)(F)c1ccnc(NCCNC(=S)NCc2ccco2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I06 compound treatment 2.22014758E8 3.06E7 0.38 2.02983677E8 6080000.0 0.1 0.3454 0.8674 3063240 Maybridge4_000182 Cc1ccc2N(CCCc2c1)C(=S)Nc3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I07 compound treatment 2.22830646E8 3.15E7 0.39 2.05776493E8 8880000.0 0.15 0.3864 0.914 3179779 Maybridge4_000183 Cc1ccc(cc1)S(=O)(=O)NCCNc2nccc(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I08 compound treatment 2.14774846E8 2.34E7 0.29 2.20369332E8 2.35E7 0.4 0.4916 0.9881 3063241 Maybridge4_000184 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc3[nH]nnc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I09 compound treatment 2.18424056E8 2.7E7 0.34 2.33616391E8 3.67E7 0.63 0.6843 0.9581 3179780 Maybridge4_000185 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)Nc3nccc(n3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I10 compound treatment 2.30312071E8 3.89E7 0.49 2.38962445E8 4.21E7 0.72 0.8545 0.9821 3063242 Maybridge4_000186 Clc1ccc2scc(/C(=C/c3cccs3)/C#N)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I11 compound treatment 2.30480095E8 3.91E7 0.49 2.3912737E8 4.22E7 0.72 0.858 0.9822 3179781 Maybridge4_000187 CCOC(=O)c1c(sc(C)c1c2ccccc2)N3C(=O)C=CC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I12 compound treatment 2.40777298E8 4.94E7 0.62 2.23810867E8 2.69E7 0.46 0.7639 0.9893 3063243 Maybridge4_000188 FC(F)(F)c1cc(NC=C2C(=O)NC(=S)NC2=O)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I13 compound treatment 2.24026859E8 3.26E7 0.41 2.14813846E8 1.79E7 0.31 0.5064 0.9898 3179782 Maybridge4_000189 Cc1nc(ccc1c2nnc(SCCCN3C(=O)c4ccccc4C3=O)o2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I14 compound treatment 2.3942066E8 4.8E7 0.6 2.16200737E8 1.93E7 0.33 0.6598 0.96 3179783 Maybridge4_000190 Cc1nc2ccc(Br)cc2c(=O)n1c3cc(ccc3N4CCOCC4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I15 compound treatment 2.42417165E8 5.1E7 0.64 2.37883034E8 4.1E7 0.7 0.9488 0.999 1704168 Maybridge4_000191 CC1(C)C2CCC1(CS(=O)(=O)N3CCCN(CC3)c4nc5ccc(Cl)cc5s4)C(=O)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I16 compound treatment 2.32040563E8 4.07E7 0.51 1.98079547E8 1180000.0 0.02 0.375 0.7345 3179784 Maybridge4_000192 COc1ccccc1NC(=O)CSc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I17 compound treatment 2.44494443E8 5.31E7 0.67 2.23312982E8 2.64E7 0.45 0.7909 0.9822 1335897 Maybridge4_000193 Clc1cc(ccc1N2C(=O)CC3(CCCC3)C2=O)S(=O)(=O)N4CCc5ccccc5C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I18 compound treatment 2.68398302E8 7.7E7 0.97 2.58008702E8 6.11E7 1.05 1.4229 0.9992 3063244 Maybridge4_000194 Cc1cccc(C)c1NC(=O)CSC(=O)c2sc3ccccc3c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I19 compound treatment 2.50378283E8 5.9E7 0.74 2.14512602E8 1.76E7 0.3 0.7365 0.9216 3179785 Maybridge4_000195 FC(F)(F)c1cc(Cl)c2nc(cn2c1)C(=O)NCCCN3CCN(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I20 compound treatment 2.58907619E8 6.75E7 0.85 2.22431096E8 2.55E7 0.44 0.908 0.9526 3063245 Maybridge4_000196 Cc1ccc2ncc(nc2c1)c3ccc(Cl)c(C)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I21 compound treatment 2.50314126E8 5.89E7 0.74 2.22039958E8 2.51E7 0.43 0.8271 0.9668 3063246 Maybridge4_000197 CN(C)/N=C(\C)/c1cc(Cl)cc(Cl)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I22 compound treatment 2.46464261E8 5.51E7 0.69 2.14827168E8 1.79E7 0.31 0.7056 0.9332 3179786 Maybridge4_000198 Cc1nc2c(Br)cc(Br)cc2c(=O)n1Cc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I23 mock treatment 2.27191874E8 3.58E7 0.45 2.03125331E8 6230000.0 0.11 0.393 0.8512 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 I24 mock treatment 2.38460008E8 4.71E7 0.59 2.0961445E8 1.27E7 0.22 0.5715 0.908 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J01 compound treatment 2.26882642E8 3.55E7 0.45 1.60011766E8 -3.69E7 -0.63 -0.1316 -0.1703 3063247 Maybridge4_000199 CSC1=NCCCN1C(=O)c2c(C)onc2c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J02 compound treatment 2.15206515E8 2.38E7 0.3 1.49113472E8 -4.78E7 -0.82 -0.3671 -0.4215 3179787 Maybridge4_000200 FC(F)(F)C1=NN(C(=O)C1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J03 compound treatment 2.16469816E8 2.51E7 0.31 1.69862379E8 -2.7E7 -0.46 -0.1047 -0.1871 3063248 Maybridge4_000201 Cc1cc(ccc1Cl)C2=Nc3ccccc3SC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J04 compound treatment 2.447148E8 5.33E7 0.67 1.54918576E8 -4.2E7 -0.72 -0.035 -0.0357 3179788 Maybridge4_000202 Cc1ccc(=O)n(n1)S(=O)(=O)c2ccc(F)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J05 compound treatment 2.32979563E8 4.16E7 0.52 1.59532439E8 -3.74E7 -0.64 -0.0833 -0.1009 3063249 Maybridge4_000203 CC(C)(C)NC(=S)NC1CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J06 compound treatment 2.13653869E8 2.23E7 0.28 1.13738969E8 -8.32E7 -1.42 -0.809 -0.5577 1412882 Maybridge4_000204 CN(NS(=O)(=O)c1ccc(Cl)cc1)c2cnn(C)c(=O)c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J07 compound treatment 2.72708102E8 8.13E7 1.02 1.63966049E8 -3.29E7 -0.56 0.3228 0.2769 3179789 Maybridge4_000205 CC1CN(CC(C)O1)C2=NCCN2S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J08 compound treatment 2.39219264E8 4.78E7 0.6 1.80317099E8 -1.66E7 -0.28 0.2236 0.3369 3063250 Maybridge4_000206 COC(=O)c1cc(OC(=O)c2nn(nc2C)c3ccccc3)n(n1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J09 compound treatment 1.76578276E8 -1.48E7 -0.19 1.80422058E8 -1.65E7 -0.28 -0.3307 -0.9794 3179790 Maybridge4_000207 FC(F)(F)c1ccc(OC(=O)NC(=O)c2c(Cl)cccc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J10 compound treatment 2.25373515E8 3.4E7 0.43 1.27243764E8 -6.97E7 -1.19 -0.5416 -0.4277 1174991 Maybridge4_000208 Clc1ccc(NC(=O)N2CCC(CC2)C(c3ccccc3)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J11 compound treatment 2.62790109E8 7.14E7 0.9 1.78226103E8 -1.87E7 -0.32 0.4074 0.4283 1235401 Maybridge4_000209 Cc1cc(Oc2ccnc3cc(Cl)ccc23)ccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J12 compound treatment 2.3242132E8 4.1E7 0.51 1.48269708E8 -4.86E7 -0.83 -0.2246 -0.2294 1558885 Maybridge4_000210 Cc1cc(cc(C)c1OC(=O)Nc2ccc(Cl)cc2)c3nn(C)c(=O)c4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J13 compound treatment 2.05093333E8 1.37E7 0.17 1.37434307E8 -5.95E7 -1.02 -0.5981 -0.5794 1586134 Maybridge4_000211 Clc1cccc(Cl)c1C(=O)NC(=O)N(Cc2ccccc2)C3CC4CCC3C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J14 compound treatment 2.09705757E8 1.83E7 0.23 1.80537499E8 -1.64E7 -0.28 -0.0355 -0.0979 3178204 Maybridge4_000212 CN(C)/C=C(\C(=O)Nc1ccc(F)c(F)c1F)/S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J15 compound treatment 2.58579851E8 6.72E7 0.84 1.99947686E8 3050000.0 0.05 0.633 0.7494 1175614 Maybridge4_000213 O=c1ncn(Cc2ccccn2)cc1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J16 compound treatment 2.58516939E8 6.71E7 0.84 1.41273215E8 -5.56E7 -0.95 -0.0778 -0.0612 1210252 Maybridge4_000214 Cc1ccc(cc1)C(=O)COc2cc(C)nc3nncn23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J17 compound treatment 2.57611766E8 6.62E7 0.83 1.89502719E8 -7400000.0 -0.13 0.498 0.5925 1235603 Maybridge4_000215 Fc1ccc(NC(=O)Cc2nn[nH]n2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J18 compound treatment 2.77833492E8 8.65E7 1.08 1.97442419E8 543000.0 0.01 0.7734 0.7131 1578276 Maybridge4_000216 CN(c1cnn(c2ccc(C)cc2)c(=O)c1Cl)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J19 compound treatment 2.60521646E8 6.91E7 0.87 1.66849389E8 -3.01E7 -0.51 0.2496 0.2475 1321013 Maybridge4_000217 COC(=O)c1sccc1OC(=O)c2nn(nc2C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J20 compound treatment 2.27379781E8 3.6E7 0.45 1.81855112E8 -1.5E7 -0.26 0.1372 0.264 3063294 Maybridge4_000218 Cc1ccc(/C=C/c2onc3c(=O)n(C)nc(C)c23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J21 compound treatment 2.52154191E8 6.08E7 0.76 1.93081451E8 -3820000.0 -0.07 0.4929 0.6441 3063295 Maybridge4_000219 CCCC/1=NN(C(=O)\C1=C\c2ccc(Cl)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J22 compound treatment 2.31384133E8 4.0E7 0.5 2.02211665E8 5310000.0 0.09 0.4192 0.8218 3063296 Maybridge4_000220 CN(C(=O)CSc1ccc(cn1)C(F)(F)F)c2c3CCCCc3nn2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J23 mock treatment 1.97931684E8 6550000.0 0.08 1.42243229E8 -5.47E7 -0.94 -0.6034 -0.6425 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 J24 mock treatment 2.08924668E8 1.75E7 0.22 1.91851294E8 -5050000.0 -0.09 0.0945 0.3998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K01 compound treatment 7.2567026E7 -1.19E8 -1.49 9.8196602E7 -9.87E7 -1.69 -2.2486 -0.998 1220864 Maybridge4_000221 CC(C)(C)c1cc(CN2C(=O)c3ccccc3C2=O)cc(c1O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K02 compound treatment 9.2824988E7 -9.86E7 -1.24 1.24898376E8 -7.2E7 -1.23 -1.7457 -1.0 3063297 Maybridge4_000222 Cc1cc2CSC(SCc2cc1C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K03 compound treatment 8.1710644E7 -1.1E8 -1.38 1.05173662E8 -9.17E7 -1.57 -2.0831 -0.9978 3178205 Maybridge4_000223 FC(F)(F)Oc1ccc(cc1)N2C(=O)CC3(CCCC3)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K04 compound treatment 1.56951183E8 -3.44E7 -0.43 1.79448839E8 -1.75E7 -0.3 -0.5166 -0.9838 3063298 Maybridge4_000224 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc3oc(=O)ccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K05 compound treatment 1.83457972E8 -7920000.0 -0.1 2.11109242E8 1.42E7 0.24 0.1017 0.3872 3178206 Maybridge4_000225 FC(F)(F)c1ccc(/C=C(\C#N)/c2cccc(c2)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K06 compound treatment 1.86033578E8 -5350000.0 -0.07 2.27770916E8 3.09E7 0.53 0.3263 0.6125 1672405 Maybridge4_000226 Clc1cccc(NC(=S)N2CCc3ccccc3C2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K07 compound treatment 1.9286751E8 1490000.0 0.02 2.22881191E8 2.6E7 0.44 0.3277 0.7362 1231870 Maybridge4_000227 Fc1ccc(CN2CCCN(CC2)C(=O)Nc3cccc(Cl)c3Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K08 compound treatment 1.91065153E8 -314000.0 0.0 2.2745465E8 3.06E7 0.52 0.3671 0.7018 1729950 Maybridge4_000228 CC(C)N(Cc1ccc(cc1)N(C)C)C(=O)c2sc3ccccc3c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K09 compound treatment 1.79609469E8 -1.18E7 -0.15 2.2241647E8 2.55E7 0.44 0.2045 0.4434 3178207 Maybridge4_000229 Cc1nc(ccc1C(=O)N2CCN(CC2)c3nc4ccc(Cl)cc4s3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K10 compound treatment 1.48970745E8 -4.24E7 -0.53 1.84234585E8 -1.27E7 -0.22 -0.5295 -0.9217 1285643 Maybridge4_000230 Clc1ccc(cc1)N(CCc2ccccn2)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K11 compound treatment 1.6633845E8 -2.5E7 -0.31 2.16189027E8 1.93E7 0.33 0.0114 0.0249 3063299 Maybridge4_000231 Clc1ccc(Cl)c(c1)n2ccnc2SCCCN3C(=O)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K12 compound treatment 1.77047151E8 -1.43E7 -0.18 2.17230148E8 2.03E7 0.35 0.119 0.3037 1594434 Maybridge4_000232 COc1ccc(cc1)C(=O)CC2(O)C(=O)N(CN3CCOCC3)c4ccc(Br)cc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K13 compound treatment 1.77876573E8 -1.35E7 -0.17 2.5051269E8 5.36E7 0.92 0.5292 0.567 3063300 Maybridge4_000233 Cc1ccc(cc1)S(=O)(=O)NC(=O)NC2CCN(CC2)c3nccc(n3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K14 compound treatment 1.5271904E8 -3.87E7 -0.48 2.12265448E8 1.54E7 0.26 -0.1569 -0.2845 1540061 Maybridge4_000234 CN1C(NC(=O)c2ccccc12)C3CCC=CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K15 compound treatment 1.91133407E8 -245000.0 0.0 2.1244112E8 1.55E7 0.27 0.1859 0.6989 3178208 Maybridge4_000235 CC(C)Nc1ncnc2scc(c3ccccc3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K16 compound treatment 1.78106965E8 -1.33E7 -0.17 2.12886382E8 1.6E7 0.27 0.0758 0.2366 3063301 Maybridge4_000236 S=C(NCCCN1CCOCC1)N2CC3CCC(CC3)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K17 compound treatment 1.87707942E8 -3670000.0 -0.05 2.09842266E8 1.29E7 0.22 0.1241 0.5484 1631820 Maybridge4_000237 COc1ccc(NS(=O)(=O)c2ccc(N3C(=O)CC4(CCCC4)C3=O)c(Cl)c2)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K18 compound treatment 1.91737925E8 359000.0 0.0 2.34319886E8 3.74E7 0.64 0.4561 0.7121 3063302 Maybridge4_000238 Cc1cc(Oc2ccc(cc2n3cccc3)C(F)(F)F)cc(C)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K19 compound treatment 1.85949683E8 -5430000.0 -0.07 1.96334077E8 -566000.0 -0.01 -0.055 -0.7996 3178209 Maybridge4_000239 FC(F)(F)c1cnc(N2CCC(CC2)N3C(=O)CC4(CCCC4)C3=O)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K20 compound treatment 2.02105361E8 1.07E7 0.13 2.24070614E8 2.72E7 0.47 0.424 0.8758 3063303 Maybridge4_000240 Clc1ccc(SC(=O)c2cccnc2Oc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K21 compound treatment 1.83531481E8 -7850000.0 -0.1 2.0947228E8 1.26E7 0.22 0.0826 0.3489 1673449 Maybridge4_000241 O=C1CCCCCCCCCCC1CN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K22 compound treatment 1.90160204E8 -1220000.0 -0.02 2.05082213E8 8180000.0 0.14 0.0882 0.6262 1443277 Maybridge4_000242 Nc1ccccc1C(=O)NCCc2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K23 mock treatment 1.12327181E8 -7.91E7 -0.99 1.07934734E8 -8.9E7 -1.52 -1.7781 -0.9784 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 K24 mock treatment 1.77892116E8 -1.35E7 -0.17 2.07461655E8 1.06E7 0.18 0.0082 0.0332 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L01 compound treatment 2.09970748E8 1.86E7 0.23 2.03653301E8 6750000.0 0.12 0.2467 0.9476 1275035 Maybridge4_000243 COC(=O)c1ccc(C)c(NC(=O)c2ccncc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L02 compound treatment 2.13191633E8 2.18E7 0.27 2.09196938E8 1.23E7 0.21 0.3423 0.9916 3178210 Maybridge4_000244 CN(C)/C=N/S(=O)(=O)c1ccc(cc1)n2nc(cc2c3cccs3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L03 compound treatment 2.20373427E8 2.9E7 0.36 1.73857467E8 -2.3E7 -0.39 -0.0217 -0.0405 1520487 Maybridge4_000245 Clc1ccc(cc1)C(=O)CNC(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L04 compound treatment 1.69043263E8 -2.23E7 -0.28 1.64542717E8 -3.24E7 -0.55 -0.5898 -0.9502 3063304 Maybridge4_000246 Fc1ccc(cc1F)C2=CSC3=NCCCN23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L05 compound treatment 2.28286781E8 3.69E7 0.46 2.32435902E8 3.55E7 0.61 0.7575 0.9909 3178211 Maybridge4_000247 CCC1(CC)N/C(=N/c2ccc(F)cc2F)/SC1=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L06 compound treatment 1.81509275E8 -9870000.0 -0.12 1.49963243E8 -4.69E7 -0.8 -0.6557 -0.8065 3063305 Maybridge4_000248 Cn1ncc(SCc2ccccc2)c(Cl)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L07 compound treatment 1.89085776E8 -2290000.0 -0.03 1.78872405E8 -1.8E7 -0.31 -0.2385 -0.7697 3178212 Maybridge4_000249 Cc1ccc(/N=C\2/NC(C)(C)C(=C)S2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L08 compound treatment 2.4591192E8 5.45E7 0.68 1.51885316E8 -4.5E7 -0.77 -0.0611 -0.0593 3178213 Maybridge4_000250 CC(=O)Nc1ccc(Oc2cncc(Cl)c2)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L09 compound treatment 1.77930299E8 -1.34E7 -0.17 1.82210113E8 -1.47E7 -0.25 -0.2971 -0.9812 3063306 Maybridge4_000251 CCOC(=S)SCc1ccc(cc1)C(=O)Oc2ccc(F)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L10 compound treatment 2.0878127E8 1.74E7 0.22 2.13548947E8 1.66E7 0.28 0.3559 0.9913 3178214 Maybridge4_000252 CC1(C)CN(C(=S)Nc2cccc(Cl)c2)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L11 compound treatment 2.0899839E8 1.76E7 0.22 2.06848437E8 9950000.0 0.17 0.2767 0.9917 3063307 Maybridge4_000253 COC(=O)/C=C/1\S/C(=N\c2ccccn2)/N(C1=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L12 compound treatment 2.22546965E8 3.12E7 0.39 2.11805854E8 1.49E7 0.26 0.4569 0.9786 1389325 Maybridge4_000254 Cc1cc(cc(C)c1OCC(=O)NN)c2nn(C)c(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L13 compound treatment 2.99593297E8 1.08E8 1.36 2.95401142E8 9.85E7 1.69 2.1522 0.9942 3063308 Maybridge4_000255 CSc1ccc(OCOc2ccc(SC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L14 compound treatment 2.15429833E8 2.41E7 0.3 2.16482152E8 1.96E7 0.34 0.4504 0.9986 3178215 Maybridge4_000256 CCOC(=O)c1c(F)c(F)c(c(F)c1F)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L15 compound treatment 2.03418757E8 1.2E7 0.15 1.98871774E8 1970000.0 0.03 0.1307 0.8443 3178216 Maybridge4_000257 CN1C(NC(=O)c2cc(Cl)ccc12)c3ccc(C#N)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L16 compound treatment 1.74213101E8 -1.72E7 -0.22 1.712534E8 -2.56E7 -0.44 -0.4627 -0.9462 1354966 Maybridge4_000258 Cc1ccc(Oc2ncccc2C(=O)NCC(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L17 compound treatment 2.28503011E8 3.71E7 0.47 2.29713119E8 3.28E7 0.56 0.7265 0.9957 3178217 Maybridge4_000259 NC(=O)Nc1ccc2[nH]ncc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L18 compound treatment 1.76292806E8 -1.51E7 -0.19 1.83670244E8 -1.32E7 -0.23 -0.294 -0.996 3063309 Maybridge4_000260 COc1cc(C)nc2nc(nn12)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L19 compound treatment 1.69768754E8 -2.16E7 -0.27 1.7994018E8 -1.7E7 -0.29 -0.397 -0.9994 3178218 Maybridge4_000261 CSc1nncc(n1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L20 compound treatment 2.12974699E8 2.16E7 0.27 2.09873202E8 1.3E7 0.22 0.3486 0.9951 1483914 Maybridge4_000262 Cc1ccc(cc1)c2cc(n[nH]2)c3c(C)nn(C)c(=O)c3N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L21 compound treatment 2.04880039E8 1.35E7 0.17 2.12735536E8 1.58E7 0.27 0.3114 0.9744 1521640 Maybridge4_000263 Nc1ccccc1C(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L22 compound treatment 1.6243829E8 -2.89E7 -0.36 1.54775437E8 -4.21E7 -0.72 -0.7666 -0.9496 3178219 Maybridge4_000264 Cc1nc(cs1)c2cc(C#N)c(Sc3cccc(c3)C(F)(F)F)nc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L23 mock treatment 1.92359984E8 981000.0 0.01 1.92736502E8 -4160000.0 -0.07 -0.0417 -0.5764 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 L24 mock treatment 1.56428696E8 -3.5E7 -0.44 1.89219887E8 -7680000.0 -0.13 -0.403 -0.8804 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M01 compound treatment 6.7128114E7 -1.24E8 -1.56 6.343069E7 -1.33E8 -2.28 -2.7177 -0.9826 3063310 Maybridge4_000265 Oc1ccccc1/N=C/C=N/c2ccccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M02 compound treatment 1.01669431E8 -8.97E7 -1.13 9.7720388E7 -9.92E7 -1.7 -1.9962 -0.9801 3178220 Maybridge4_000266 CN(CCC#N)c1ccc(cc1)C2SCc3cc(C)c(C)cc3CS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M03 compound treatment 5.5789578E7 -1.36E8 -1.7 4.8193333E7 -1.49E8 -2.55 -3.0027 -0.9808 3063311 Maybridge4_000267 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCCN(CC2)c3ccc(cn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M04 compound treatment 1.6444755E8 -2.69E7 -0.34 1.50587409E8 -4.63E7 -0.79 -0.7995 -0.9277 3178221 Maybridge4_000268 Cc1onc(c1C(=O)N2CCCc3cccc(C)c23)c4c(Cl)cccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M05 compound treatment 1.87648961E8 -3730000.0 -0.05 1.88791427E8 -8110000.0 -0.14 -0.1312 -0.8959 1280324 Maybridge4_000269 Cc1c(Cl)cccc1NC(=S)N2CCCN(CC2)c3nc4ccc(Cl)cc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M06 compound treatment 1.82363989E8 -9010000.0 -0.11 1.77386475E8 -1.95E7 -0.33 -0.3162 -0.8965 1592820 Maybridge4_000270 Cc1ccccc1NC(=S)Nc2ccccc2C(=O)Nc3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M07 compound treatment 1.46612279E8 -4.48E7 -0.56 1.50066913E8 -4.68E7 -0.8 -0.964 -0.9848 3178222 Maybridge4_000271 Cc1nc(ccc1C(=O)Oc2ccc(OC(F)(F)F)cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M08 compound treatment 1.89066766E8 -2310000.0 -0.03 1.92780756E8 -4120000.0 -0.07 -0.0704 -0.9229 1647940 Maybridge4_000272 Cc1cc(OCc2c(C)c(C)c(C)c(C)c2C)c3cc(Cl)ccc3n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M09 compound treatment 1.74227199E8 -1.72E7 -0.22 1.61015232E8 -3.59E7 -0.61 -0.5865 -0.9011 3178223 Maybridge4_000273 Cc1ccc(NC(=S)N2CCC(CC2)Nc3nccc(n3)C(F)(F)F)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M10 compound treatment 1.954744E8 4100000.0 0.05 1.81145325E8 -1.58E7 -0.27 -0.1544 -0.5623 1291651 Maybridge4_000274 CC(C)c1ccc(cc1)N(CCc2ccccn2)S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M11 compound treatment 2.06751761E8 1.54E7 0.19 1.88028436E8 -8870000.0 -0.15 0.029 0.1181 3178308 Maybridge4_000275 FC(F)(F)c1cccnc1NCCNc2ncnc3scc(c4ccccc4)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M12 compound treatment 1.87545451E8 -3830000.0 -0.05 1.66924322E8 -3.0E7 -0.51 -0.3968 -0.77 3178309 Maybridge4_000276 Fc1ccc(cc1)C2CN3C(=N2)C=Cc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M13 compound treatment 2.09712234E8 1.83E7 0.23 1.87115089E8 -9780000.0 -0.17 0.0442 0.1553 1327290 Maybridge4_000277 COC(=O)c1cc(C#N)c(C)nc1Sc2nccn2c3cc(Cl)ccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M14 compound treatment 2.26414443E8 3.5E7 0.44 2.08931165E8 1.2E7 0.21 0.4564 0.9403 1331303 Maybridge4_000278 O=C1NC(Nc2ccccc12)C3CCC=CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M15 compound treatment 1.87545508E8 -3830000.0 -0.05 1.50080116E8 -4.68E7 -0.8 -0.6007 -0.7482 1371250 Maybridge4_000279 CC(C)NS(=O)(=O)c1ccc(N2C(=O)CC3(CCCC3)C2=O)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M16 compound treatment 2.33068622E8 4.17E7 0.52 2.23069196E8 2.62E7 0.45 0.6866 0.997 1643068 Maybridge4_000280 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)N2CC3CCC(CC3)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M17 compound treatment 2.01869559E8 1.05E7 0.13 1.88430535E8 -8470000.0 -0.14 -0.0095 -0.0483 1732462 Maybridge4_000281 CCOC(=O)C1CCN(CC1)S(=O)(=O)c2ccc(N3C(=O)CC4(CCCC4)C3=O)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M18 compound treatment 1.72195218E8 -1.92E7 -0.24 1.30733416E8 -6.62E7 -1.13 -0.9711 -0.8386 1423781 Maybridge4_000282 Cc1cc(ccc1Cl)C(=O)c2cc3cc(Cl)ccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M19 compound treatment 2.03007169E8 1.16E7 0.15 1.79379702E8 -1.75E7 -0.3 -0.1089 -0.3266 3178310 Maybridge4_000283 Fc1cccc(Cl)c1CN2CCN(CCCNc3ncnc4scc(c5ccccc5)c34)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M20 compound treatment 2.06561294E8 1.52E7 0.19 1.94681922E8 -2220000.0 -0.04 0.1078 0.5552 3063131 Maybridge4_000284 NNC(=O)c1cccnc1Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M21 compound treatment 1.4169336E8 -4.97E7 -0.62 1.08238254E8 -8.87E7 -1.52 -1.5139 -0.9227 3063132 Maybridge4_000285 Fc1ccc(/C=C/c2cccc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M22 compound treatment 1.46003471E8 -4.54E7 -0.57 1.12034706E8 -8.49E7 -1.45 -1.4297 -0.9163 3178311 Maybridge4_000286 Cc1ccc(SCCNC(=O)c2cccnc2Oc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M23 mock treatment 1.11878346E8 -7.95E7 -1.0 8.8496618E7 -1.08E8 -1.86 -2.0173 -0.9576 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 M24 mock treatment 1.94850902E8 3470000.0 0.04 1.78831751E8 -1.81E7 -0.31 -0.1879 -0.6016 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N01 compound treatment 2.03811296E8 1.24E7 0.16 2.06680474E8 9780000.0 0.17 0.2287 0.9994 1041669 Maybridge4_000287 O=C(CSCC(=O)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N02 compound treatment 2.35955283E8 4.46E7 0.56 1.33661506E8 -6.32E7 -1.08 -0.37 -0.3037 3178312 Maybridge4_000288 COC(=O)c1cccnc1SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N03 compound treatment 1.95890532E8 4510000.0 0.06 1.91346913E8 -5550000.0 -0.1 -0.0272 -0.2458 3063133 Maybridge4_000289 Cc1ccccc1c2ncc(o2)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N04 compound treatment 2.00309551E8 8930000.0 0.11 2.00825422E8 3930000.0 0.07 0.1267 0.9701 3178313 Maybridge4_000290 Fc1ccc(cc1F)C2=NNC3=NCCN3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N05 compound treatment 1.50927385E8 -4.05E7 -0.51 2.2305429E8 2.62E7 0.45 -0.0422 -0.0624 3178314 Maybridge4_000291 Clc1ccc(NC(=N)c2ccccc2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N06 compound treatment 2.1765367E8 2.63E7 0.33 2.13276588E8 1.64E7 0.28 0.4313 0.9968 1155893 Maybridge4_000292 CSc1nnc(SC)n1CCNC(=O)c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N07 compound treatment 2.32496461E8 4.11E7 0.52 2.17314243E8 2.04E7 0.35 0.6118 0.982 3178315 Maybridge4_000293 CCc1cccc(CC)c1/N=C\2/NC(C)(C)C(=C)S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N08 compound treatment 2.14475695E8 2.31E7 0.29 2.09656587E8 1.28E7 0.22 0.3593 0.9903 3178316 Maybridge4_000294 FC(F)(F)c1ccc(nc1)S(=O)(=O)CC2=NN(C(=O)C2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N09 compound treatment 1.97786182E8 6410000.0 0.08 1.86630791E8 -1.03E7 -0.18 -0.0675 -0.349 1286323 Maybridge4_000295 COC(=O)c1sc2ccccc2c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N10 compound treatment 2.22055238E8 3.07E7 0.38 2.09882163E8 1.3E7 0.22 0.4293 0.966 1418804 Maybridge4_000296 Nc1ccccc1Nc2nc(=O)n(Cc3ccc(Cl)cc3)cc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N11 compound treatment 1.68232632E8 -2.31E7 -0.29 1.56077476E8 -4.08E7 -0.7 -0.6994 -0.9243 1326126 Maybridge4_000297 Cc1ccc(COn2c(nc3ccccc3c2=O)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N12 compound treatment 2.20530803E8 2.92E7 0.37 1.60625921E8 -3.63E7 -0.62 -0.1805 -0.2505 1242548 Maybridge4_000298 Cc1ccn2c(=O)c(cnc2c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N13 compound treatment 2.5608879E8 6.47E7 0.81 2.75731012E8 7.88E7 1.35 1.5282 0.9704 3178317 Maybridge4_000299 N#Cc1ccc(OCOc2ccc(C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N14 compound treatment 2.09333628E8 1.8E7 0.23 2.12974551E8 1.61E7 0.28 0.3538 0.9951 3063134 Maybridge4_000300 CC(C)Sc1nnc(S)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N15 compound treatment 1.8712468E8 -4250000.0 -0.05 2.15250159E8 1.84E7 0.31 0.1844 0.5787 3178318 Maybridge4_000301 Cn1c(nc(=O)c2cc(Cl)ccc12)c3cc(Br)cs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N16 compound treatment 1.49411181E8 -4.2E7 -0.53 1.42092648E8 -5.48E7 -0.94 -1.0357 -0.9627 3178319 Maybridge4_000302 Cc1ccc(/C=C/2\N=C(OC2=O)c3ccccc3N(CC=C)S(=O)(=O)c4ccc(C)cc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N17 compound treatment 2.18016766E8 2.66E7 0.33 2.09067468E8 1.22E7 0.21 0.3836 0.9741 3063135 Maybridge4_000303 Cc1onc(NC(=O)NC(=O)c2ccccc2F)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N18 compound treatment 1.5626449E8 -3.51E7 -0.44 1.53953702E8 -4.29E7 -0.74 -0.8313 -0.97 3063136 Maybridge4_000304 CC(C)(C)OC(=O)C(C)(C)S(=O)(=O)c1ccc(cn1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N19 compound treatment 1.95697504E8 4320000.0 0.05 2.27448199E8 3.05E7 0.52 0.4081 0.7762 3178320 Maybridge4_000305 Clc1cc(Cl)c2nc(Oc3cccc(c3)N4CCOCC4)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N20 compound treatment 1.70177886E8 -2.12E7 -0.27 1.69582103E8 -2.73E7 -0.47 -0.5187 -0.9642 3063137 Maybridge4_000306 CCOC(=O)c1nn(c2ccccc2)c(=N)c(C#N)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N21 compound treatment 1.58623999E8 -3.28E7 -0.41 1.54942523E8 -4.2E7 -0.72 -0.7984 -0.9649 3178321 Maybridge4_000307 Cc1nn(nc1c2nnc(o2)c3ccc(Cl)c(Cl)c3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N22 compound treatment 2.0628177E8 1.49E7 0.19 2.03143912E8 6240000.0 0.11 0.2078 0.9648 3178322 Maybridge4_000308 Cc1nc(cs1)c2cc(C#N)c(Oc3ccc(cc3)C(F)(F)F)nc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N23 mock treatment 1.93029472E8 1650000.0 0.02 1.98454325E8 1550000.0 0.03 0.0335 0.9923 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 N24 mock treatment 1.50480453E8 -4.09E7 -0.51 1.63192665E8 -3.37E7 -0.58 -0.7708 -0.9983 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O01 compound treatment 1.11435003E8 -7.99E7 -1.0 1.02871236E8 -9.4E7 -1.61 -1.8473 -0.9741 3063138 Maybridge4_000309 Cn1cc(c(n1)C(F)(F)F)S(=O)(=O)NCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O02 compound treatment 1.22213343E8 -6.92E7 -0.87 1.06438561E8 -9.05E7 -1.55 -1.7085 -0.9625 1336600 Maybridge4_000310 Clc1ccccc1n2c(n[nH]c2=S)C3CCCNC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O03 compound treatment 1.18277439E8 -7.31E7 -0.92 9.9645177E7 -9.73E7 -1.66 -1.8256 -0.9605 3063139 Maybridge4_000311 Cc1cccc(Cl)c1NC(=O)N2CCCN(CC2)c3ncccc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O04 compound treatment 1.41301289E8 -5.01E7 -0.63 1.17216962E8 -7.97E7 -1.36 -1.4087 -0.9381 3178323 Maybridge4_000312 CCOC(=O)c1c(C)onc1c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O05 compound treatment 1.81944602E8 -9430000.0 -0.12 1.66731878E8 -3.02E7 -0.52 -0.4488 -0.8472 1600108 Maybridge4_000313 OC1CCN(CC1)C(=O)Nc2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O06 compound treatment 2.10085582E8 1.87E7 0.23 1.80461654E8 -1.64E7 -0.28 -0.033 -0.0902 1675860 Maybridge4_000314 CCN(Cc1cc(OC)c(OC)c(OC)c1)C(=S)Nc2cccc(SC)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O07 compound treatment 1.84828418E8 -6550000.0 -0.08 1.63998726E8 -3.29E7 -0.56 -0.4563 -0.8018 3063188 Maybridge4_000315 Cc1nc(ccc1C(=O)NCC=C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O08 compound treatment 2.16815006E8 2.54E7 0.32 1.87166301E8 -9730000.0 -0.17 0.1078 0.2995 1638858 Maybridge4_000316 Cc1nc2cc(Cl)ccc2c(=O)n1CC3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O09 compound treatment 2.12694263E8 2.13E7 0.27 1.85286641E8 -1.16E7 -0.2 0.0485 0.1456 1730664 Maybridge4_000317 CCOC(=O)c1cc(C(=O)OC)c(C)nc1N2CCC(CC2)NC3CCCCC3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O10 compound treatment 2.10947433E8 1.96E7 0.25 1.93517816E8 -3380000.0 -0.06 0.1326 0.5259 1134448 Maybridge4_000318 Fc1ccc(NC(=S)N2CCCCC2CCN3CCOCC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O11 compound treatment 1.90289168E8 -1090000.0 -0.01 1.65982953E8 -3.09E7 -0.53 -0.3839 -0.7251 3063189 Maybridge4_000319 OC(=O)/C=C/C(=O)NC1CCN(CC1)c2nccc(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O12 compound treatment 1.70526968E8 -2.09E7 -0.26 1.482211E8 -4.87E7 -0.83 -0.7742 -0.8864 3178324 Maybridge4_000320 C1C(N=C2C=Cc3ccccc3N12)c4ccc5ccccc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O13 compound treatment 2.12605319E8 2.12E7 0.27 1.95124566E8 -1780000.0 -0.03 0.1668 0.6224 1152090 Maybridge4_000321 CC1CN(CC(C)O1)S(=O)(=O)c2ccc(N3C(=O)CC4(CCCC4)C3=O)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O14 compound treatment 2.02849778E8 1.15E7 0.14 2.03669993E8 6770000.0 0.12 0.1837 0.9942 1502131 Maybridge4_000322 Nc1n(nc2cc(O)nc(O)c12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O15 compound treatment 2.21264834E8 2.99E7 0.37 2.10181355E8 1.33E7 0.23 0.4259 0.9713 1406030 Maybridge4_000323 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c2ccccc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O16 compound treatment 2.27450935E8 3.61E7 0.45 2.17517283E8 2.06E7 0.35 0.5695 0.9924 1015155 Maybridge4_000324 O=c1ccc(=O)n([nH]1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O17 compound treatment 1.94437868E8 3060000.0 0.04 1.91145979E8 -5750000.0 -0.1 -0.0425 -0.4022 3178325 Maybridge4_000325 Cc1nc(nc(NC2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)c1Cl)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O18 compound treatment 2.22792198E8 3.14E7 0.39 2.04444746E8 7540000.0 0.13 0.37 0.8922 3063190 Maybridge4_000326 Cc1cc(NC(=S)NC(C)(C)C)ccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O19 compound treatment 2.09068215E8 1.77E7 0.22 1.99126797E8 2230000.0 0.04 0.1839 0.8166 1373262 Maybridge4_000327 S=C(NC1CC1)N2CCCN(Cc3cccc4ccccc34)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O20 compound treatment 2.07878653E8 1.65E7 0.21 2.14620506E8 1.77E7 0.3 0.3609 0.9826 3178326 Maybridge4_000328 N#Cc1cccnc1Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O21 compound treatment 1.38046102E8 -5.33E7 -0.67 1.45653685E8 -5.12E7 -0.88 -1.0934 -0.9911 3178327 Maybridge4_000329 Cc1cc(C(=O)NN)c2cc(Br)ccc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O22 compound treatment 1.37384591E8 -5.4E7 -0.68 1.45060212E8 -5.18E7 -0.89 -1.1064 -0.9911 3063191 Maybridge4_000330 CC(C)(C)NC(=S)Nc1cc(ccc1N2CCCCC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O23 mock treatment 2.04234439E8 1.29E7 0.16 1.98491751E8 1590000.0 0.03 0.1333 0.815 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 O24 mock treatment 1.98065681E8 6690000.0 0.08 2.06046491E8 9150000.0 0.16 0.17 0.9572 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P01 compound treatment 2.02110831E8 1.07E7 0.13 1.85018402E8 -1.19E7 -0.2 -0.0486 -0.1993 3178328 Maybridge4_000331 Fc1ccc(cc1Cl)C(=O)NC(=O)Nc2nnc(s2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P02 compound treatment 1.93412345E8 2030000.0 0.03 1.94307873E8 -2590000.0 -0.04 -0.0133 -0.2606 3178329 Maybridge4_000332 CN(C)/C=C/1\C(=O)c2ccc(Cl)cc2N(Cc3c(F)cccc3Cl)S1(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P03 compound treatment 2.02751433E8 1.14E7 0.14 2.03810838E8 6910000.0 0.12 0.1845 0.9957 3063192 Maybridge4_000333 Fc1ccccc1C(=O)NC(=O)OCc2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P04 compound treatment 2.1119751E8 1.98E7 0.25 2.07849015E8 1.09E7 0.19 0.3083 0.9903 3063193 Maybridge4_000334 CN1N=C(CC1=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P05 compound treatment 1.7057634E8 -2.08E7 -0.26 1.70437834E8 -2.65E7 -0.45 -0.5048 -0.9657 3178330 Maybridge4_000335 Clc1ccc(cc1)S(=O)(=O)Nc2ccccc2C(=O)NCCCn3ccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P06 compound treatment 1.4084007E8 -5.05E7 -0.63 1.44279759E8 -5.26E7 -0.9 -1.0852 -0.9852 3063194 Maybridge4_000336 CN(C)/C=N/c1cc(Cl)c(cc1Oc2ccc(Cl)cc2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P07 compound treatment 2.0892931E8 1.76E7 0.22 2.08125366E8 1.12E7 0.19 0.2916 0.9977 3178331 Maybridge4_000337 CSC1=NCCN1CC(=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P08 compound treatment 2.0249884E8 1.11E7 0.14 2.04894705E8 7990000.0 0.14 0.1954 1.0 3178429 Maybridge4_000338 Oc1c(C(=O)c2ccccc2)c(CS(=O)(=O)c3ccc(cn3)C(F)(F)F)nn1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P09 compound treatment 2.14728628E8 2.33E7 0.29 1.95297103E8 -1600000.0 -0.03 0.1877 0.6381 3063195 Maybridge4_000339 FC(F)(F)c1ccc2[nH]c(SCc3cccc(C#N)c3)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P10 compound treatment 1.93479402E8 2100000.0 0.03 1.9165889E8 -5240000.0 -0.09 -0.0448 -0.4792 3178430 Maybridge4_000340 COc1ccccc1N2CC(C)(C)C(=O)N(C(=O)c3ccc(C)cc3)C2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P11 compound treatment 1.55896134E8 -3.55E7 -0.45 1.59446469E8 -3.75E7 -0.64 -0.7681 -0.9841 1567114 Maybridge4_000341 Brc1ccc(COn2c(nc3ccccc3c2=O)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P12 compound treatment 2.03307081E8 1.19E7 0.15 1.96755925E8 -144000.0 0.0 0.1041 0.6954 1250229 Maybridge4_000342 CCCCN1C(C(=O)N(C1=O)c2nnc(s2)C(C)(C)C)c3ccc(Cl)c(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P13 compound treatment 2.25558614E8 3.42E7 0.43 2.14438974E8 1.75E7 0.3 0.5155 0.9848 3063196 Maybridge4_000343 COC(=O)/C=c/1\sc2nc3cc(Cl)c(Cl)cc3n2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P14 compound treatment 1.94217396E8 2840000.0 0.04 1.91454134E8 -5450000.0 -0.09 -0.0407 -0.4082 3178431 Maybridge4_000344 FC(F)(F)c1ccc(nc1)S(=O)(=O)CCOC(=O)c2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P15 compound treatment 1.97882469E8 6500000.0 0.08 1.93171669E8 -3730000.0 -0.06 0.0126 0.1213 3063197 Maybridge4_000345 CC(C)(C)SCCNc1nc(Oc2ccc(F)cc2)nc(Oc3ccc(F)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P16 compound treatment 1.9749119E8 6110000.0 0.08 1.82608525E8 -1.43E7 -0.24 -0.1188 -0.4633 3178432 Maybridge4_000346 N=C1CC(=O)N=C2SC(=NN21)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P17 compound treatment 2.10410793E8 1.9E7 0.24 2.08891241E8 1.2E7 0.21 0.314 0.9972 3063198 Maybridge4_000347 COC(=O)/C(=C/N(C)C)/Sc1cc(C)c(Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P18 compound treatment 2.05947665E8 1.46E7 0.18 2.03009823E8 6110000.0 0.1 0.2032 0.9649 3178433 Maybridge4_000348 CSc1nc(C)nc(Sc2ccccc2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P19 compound treatment 2.08388771E8 1.7E7 0.21 2.16410785E8 1.95E7 0.33 0.387 0.9766 3178434 Maybridge4_000349 Cc1cc(Oc2nc3cc(Cl)ccc3s2)c4cc(Cl)ccc4n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P20 compound treatment 1.90126953E8 -1250000.0 -0.02 1.7909919E8 -1.78E7 -0.3 -0.2266 -0.7426 1222979 Maybridge4_000350 CSC1=NN(C)c2cnn(C)c(=O)c2S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P21 compound treatment 2.0829361E8 1.69E7 0.21 1.97918677E8 1020000.0 0.02 0.1624 0.7627 1579106 Maybridge4_000351 O=C(CC#N)NCc1ccccn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P22 compound treatment 2.03034937E8 1.17E7 0.15 2.04167809E8 7270000.0 0.12 0.1914 0.9968 1689187 Maybridge4_000352 Clc1ccc(SCC(=O)c2ccc3NC(=O)CCc3c2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P23 mock treatment 2.01659772E8 1.03E7 0.13 2.07967353E8 1.11E7 0.19 0.2252 0.9824 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2049 P24 mock treatment 1.63993558E8 -2.74E7 -0.34 1.89928936E8 -6970000.0 -0.12 -0.3273 -0.9 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A01 compound treatment 1.19346544E8 -7.59E7 -0.95 1.31580297E8 -6.42E7 -1.1 -1.4511 -0.9974 3063199 Maybridge4_000353 O=C1CCc2cc(ccc2N1)C3=CSC4=NCCN34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A02 compound treatment 1.33154023E8 -6.21E7 -0.78 1.44161291E8 -5.17E7 -0.88 -1.1764 -0.998 3178435 Maybridge4_000354 CC1(C)OC(=O)C(C2C3CC4CC(C3)CC2C4)C(=O)O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A03 compound treatment 1.40832966E8 -5.45E7 -0.68 1.47894013E8 -4.79E7 -0.82 -1.0631 -0.9959 3178436 Maybridge4_000355 Cc1nc(cs1)c2cc(C#N)c(SCCNC(=O)c3ccc(Cl)cc3Cl)nc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A04 compound treatment 1.50124743E8 -4.52E7 -0.57 1.5159695E8 -4.42E7 -0.76 -0.9358 -0.9898 1602887 Maybridge4_000356 CC1(C)Oc2c(C=C1)c3c(=O)cc(oc3c4ccoc24)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A05 compound treatment 1.80108933E8 -1.52E7 -0.19 1.70046189E8 -2.58E7 -0.44 -0.4465 -0.9294 3063200 Maybridge4_000357 COc1cc(OC)nc(/N=C/N(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A06 compound treatment 1.82136063E8 -1.32E7 -0.16 1.74636923E8 -2.12E7 -0.36 -0.373 -0.9365 3178437 Maybridge4_000358 CC1(C)CN=C(NC2CCCCC2)S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A07 compound treatment 1.85257834E8 -1.0E7 -0.13 1.80399367E8 -1.54E7 -0.26 -0.2756 -0.9426 3178438 Maybridge4_000359 COc1ccc(CCC(=O)CCc2ccc(OC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A08 compound treatment 1.85421948E8 -9870000.0 -0.12 1.79719044E8 -1.61E7 -0.28 -0.2823 -0.9348 3063201 Maybridge4_000360 COc1ccccc1OC(=O)NC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A09 compound treatment 1.67448172E8 -2.78E7 -0.35 1.66363343E8 -2.95E7 -0.5 -0.6034 -0.9839 3178439 Maybridge4_000361 CCOC(=O)c1ccc(cc1)C(=S)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A10 compound treatment 2.02215688E8 6930000.0 0.09 1.866089E8 -9210000.0 -0.16 -0.05 -0.2777 1174208 Maybridge4_000362 CCC1(CCCCN(C)C1=O)c2cccc(OC(=O)C3CCCCC3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A11 compound treatment 2.0977954E8 1.45E7 0.18 1.88335939E8 -7480000.0 -0.13 0.038 0.171 3063202 Maybridge4_000363 CN(C)Cc1c(C)cc(C)cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A12 compound treatment 2.01426236E8 6140000.0 0.08 1.80183617E8 -1.56E7 -0.27 -0.1347 -0.484 1469863 Maybridge4_000364 O=C(Nc1nc(cs1)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A13 compound treatment 2.18768586E8 2.35E7 0.29 1.92012701E8 -3800000.0 -0.07 0.1623 0.5379 1002608 Maybridge4_000365 CCOC(=O)c1cnc(S)nc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A14 compound treatment 2.12097533E8 1.68E7 0.21 1.86885021E8 -8930000.0 -0.15 0.041 0.1575 1583969 Maybridge4_000366 Clc1cccc(c1)C(=O)NC2CN3CCC2CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A15 compound treatment 2.13990393E8 1.87E7 0.23 2.04034393E8 8220000.0 0.14 0.2654 0.9701 3063203 Maybridge4_000367 COc1cc(C#N)c2ccc3ccccc3c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A16 compound treatment 2.29854235E8 3.46E7 0.43 2.07488261E8 1.17E7 0.2 0.4479 0.9381 3178440 Maybridge4_000368 CCNC(=Nc1ccc(Cl)cc1)NCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A17 compound treatment 2.1208051E8 1.68E7 0.21 1.81683509E8 -1.41E7 -0.24 -0.0221 -0.0689 1368926 Maybridge4_000369 CC(=O)OCc1ccccc1Sc2ccccc2C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A18 compound treatment 1.80610499E8 -1.47E7 -0.18 1.64447777E8 -3.14E7 -0.54 -0.5099 -0.8982 1219932 Maybridge4_000370 C1C=C(Nc2nnnn12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A19 compound treatment 1.96276216E8 988000.0 0.01 1.87402509E8 -8410000.0 -0.14 -0.0931 -0.6438 1528436 Maybridge4_000371 Cn1c(nc2ccccc12)N3C(=O)c4cccc5cccc(C3=O)c45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A20 compound treatment 2.01793075E8 6510000.0 0.08 1.93764918E8 -2050000.0 -0.04 0.0329 0.3704 1375750 Maybridge4_000372 CC1(CC2CC3(C)C1)CC(C2)(C3)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A21 compound treatment 2.04399884E8 9110000.0 0.11 1.79288166E8 -1.65E7 -0.28 -0.1192 -0.3907 1405005 Maybridge4_000373 O=c1nc2sc3ccccc3n2c(=O)n1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A22 compound treatment 1.91442803E8 -3850000.0 -0.05 1.81849459E8 -1.4E7 -0.24 -0.2031 -0.833 3063251 Maybridge4_000374 C/S(=N\S(=O)(=O)c1ccc(Cl)cc1)/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A23 mock treatment 2.10967221E8 1.57E7 0.2 1.93080983E8 -2730000.0 -0.05 0.106 0.5243 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 A24 mock treatment 2.08538683E8 1.33E7 0.17 1.95131642E8 -683000.0 -0.01 0.1093 0.6558 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B01 compound treatment 1.91244309E8 -4040000.0 -0.05 1.67979486E8 -2.78E7 -0.48 -0.3728 -0.778 3063252 Maybridge4_000375 C1CN(C1)C(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B02 compound treatment 2.03191871E8 7900000.0 0.1 1.87097854E8 -8720000.0 -0.15 -0.0354 -0.1976 3063253 Maybridge4_000376 CC1CCC(C)N1c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B03 compound treatment 1.84884817E8 -1.04E7 -0.13 1.79869294E8 -1.59E7 -0.27 -0.2853 -0.943 3063254 Maybridge4_000377 Cc1ccc(cc1)S(=O)(=O)C[C@H]2O[C@H](C[C@@H]2O)n3cc(I)c(=O)[nH]c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B04 compound treatment 2.05559381E8 1.03E7 0.13 1.78887794E8 -1.69E7 -0.29 -0.1138 -0.3588 3063255 Maybridge4_000378 C/C(=N\O)/c1cc(Cl)cc(Cl)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B05 compound treatment 2.01825576E8 6540000.0 0.08 1.91810269E8 -4000000.0 -0.07 0.0095 0.0891 3063256 Maybridge4_000379 CCN(CC)Cc1c(C)c(C)c(C)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B06 compound treatment 1.99606566E8 4320000.0 0.05 1.71142791E8 -2.47E7 -0.42 -0.2603 -0.6114 3178441 Maybridge4_000380 Oc1c(Cl)cc(Cl)cc1C2Nc3cc(ccc3-n4cccc24)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B07 compound treatment 1.89070757E8 -6220000.0 -0.08 1.74649206E8 -2.12E7 -0.36 -0.3113 -0.8401 1227211 Maybridge4_000381 CCC(C)(C)NC(=S)Nc1cccc(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B08 compound treatment 1.98855316E8 3570000.0 0.04 1.79786635E8 -1.6E7 -0.27 -0.1624 -0.5841 3178442 Maybridge4_000382 Cc1c(C)c(C)c2[nH]c(SCc3nc(no3)c4ccc(Cl)cc4)nc2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B09 compound treatment 2.075968E8 1.23E7 0.15 1.76206291E8 -1.96E7 -0.34 -0.1282 -0.3469 3063257 Maybridge4_000383 CSC1=C(C#N)C(=O)NC(S1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B10 compound treatment 1.85093248E8 -1.02E7 -0.13 1.67342059E8 -2.85E7 -0.49 -0.4351 -0.8634 3178443 Maybridge4_000384 C/C(=N\Cc1ccccc1)/c2c(C)cc(C)cc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B11 compound treatment 1.28582442E8 -6.67E7 -0.84 1.13206058E8 -8.26E7 -1.41 -1.5916 -0.9686 1417340 Maybridge4_000385 COc1cc(cc(OC)c1OC)C2Nc3ccccc3S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B12 compound treatment 1.91517417E8 -3770000.0 -0.05 1.07205122E8 -8.86E7 -1.52 -1.106 -0.7288 1464378 Maybridge4_000386 N#CC1CN(CCc2ccccc2)CN(CCc3ccccc3)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B13 compound treatment 2.00352002E8 5060000.0 0.06 1.91800709E8 -4010000.0 -0.07 -0.0037 -0.0391 1213608 Maybridge4_000387 COc1cc(CO)c(CC(=O)NN)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B14 compound treatment 2.07539536E8 1.23E7 0.15 1.79954516E8 -1.59E7 -0.27 -0.0833 -0.267 1103050 Maybridge4_000388 CC1(C)OC(=O)C(=Cc2ccc[nH]2)C(=O)O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B15 compound treatment 2.27681807E8 3.24E7 0.41 1.73331789E8 -2.25E7 -0.38 0.0152 0.0272 1559616 Maybridge4_000389 COc1cc(OC)cc(c1)c2nc(N)c3c(C)c(sc3n2)c4ccc(OC)c(OC)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B16 compound treatment 2.18726982E8 2.34E7 0.29 1.86026969E8 -9790000.0 -0.17 0.0894 0.2643 1513039 Maybridge4_000390 Cc1onc(c1NC(=O)N2CCCC2=O)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B17 compound treatment 2.11267222E8 1.6E7 0.2 1.84878333E8 -1.09E7 -0.19 0.0094 0.0342 1918178 Maybridge4_000391 Cc1ccc(NC(=O)C2C(C3CC2C=C3)C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B18 compound treatment 1.77248051E8 -1.8E7 -0.23 1.73579561E8 -2.22E7 -0.38 -0.4292 -0.9692 3178444 Maybridge4_000392 CS/C(=N\c1ccccc1C(F)(F)F)/N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B19 compound treatment 2.09873396E8 1.46E7 0.18 1.91836144E8 -3980000.0 -0.07 0.0812 0.4161 3178445 Maybridge4_000393 CCOC(=O)c1nc2ccccc2c(=O)n1/N=C/c3cc(Cl)cc(Cl)c3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B20 compound treatment 2.10110108E8 1.48E7 0.19 1.89213791E8 -6600000.0 -0.11 0.0516 0.2371 3063259 Maybridge4_000394 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B21 compound treatment 1.97454746E8 2170000.0 0.03 1.81388619E8 -1.44E7 -0.25 -0.1554 -0.6255 3063260 Maybridge4_000395 CSC(=NS(=O)(=O)c1ccccc1)SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B22 compound treatment 2.08208082E8 1.29E7 0.16 1.83421796E8 -1.24E7 -0.21 -0.0354 -0.1326 1232359 Maybridge4_000396 Cc1onc(c1C(=O)ON2C(=O)CCC2=O)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B23 mock treatment 2.06031297E8 1.07E7 0.13 1.82932206E8 -1.29E7 -0.22 -0.0606 -0.2346 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 B24 mock treatment 2.04473761E8 9190000.0 0.12 1.74189181E8 -2.16E7 -0.37 -0.1803 -0.465 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C01 compound treatment 1.22978011E8 -7.23E7 -0.91 1.30486005E8 -6.53E7 -1.12 -1.4322 -0.9946 3063261 Maybridge4_000397 CN(C(=O)COc1cc(n(C)n1)C(F)(F)F)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C02 compound treatment 1.43365677E8 -5.19E7 -0.65 1.47577064E8 -4.82E7 -0.83 -1.0444 -0.9931 1015362 Maybridge4_000398 CCOC(=O)c1cccc2C(=O)c3ccccc3-c21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C03 compound treatment 1.55052819E8 -4.02E7 -0.5 1.50799141E8 -4.5E7 -0.77 -0.9018 -0.979 1410184 Maybridge4_000399 Cc1ccc(Oc2ncccc2NC(=O)c3ccc(Cl)cc3Cl)c4CCCc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C04 compound treatment 1.64267828E8 -3.1E7 -0.39 1.54320702E8 -4.15E7 -0.71 -0.7774 -0.9599 1430911 Maybridge4_000400 OC(=O)CCC(=O)c1ccc2OCCCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C05 compound treatment 1.7632909E8 -1.9E7 -0.24 1.56251503E8 -3.96E7 -0.68 -0.647 -0.9015 3063262 Maybridge4_000401 COc1cc(OC)nc(N/C=N/O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C06 compound treatment 1.82245156E8 -1.3E7 -0.16 1.59733859E8 -3.61E7 -0.62 -0.5524 -0.8646 1594886 Maybridge4_000402 Cn1c(=O)cc(Nc2ccccc2)c3c(=O)n(c4ccccc4)c(=O)n(c5ccccc5)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C07 compound treatment 1.93414282E8 -1870000.0 -0.02 1.66095238E8 -2.97E7 -0.51 -0.3763 -0.739 3063263 Maybridge4_000403 OC(=O)c1cc(=O)c2c(O)cccc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C08 compound treatment 1.83321127E8 -1.2E7 -0.15 1.58102768E8 -3.77E7 -0.65 -0.5626 -0.8489 3063264 Maybridge4_000404 CC(C)NC(=O)Oc1cccc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C09 compound treatment 1.6854994E8 -2.67E7 -0.34 1.45617136E8 -5.02E7 -0.86 -0.8448 -0.9158 3178446 Maybridge4_000405 COC(=O)c1ccc(cc1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C10 compound treatment 1.76112659E8 -1.92E7 -0.24 1.68684724E8 -2.71E7 -0.46 -0.4985 -0.9531 1676301 Maybridge4_000406 COC(=O)C1C(NC(C(C(=O)OC)S1(=O)=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C11 compound treatment 1.82560543E8 -1.27E7 -0.16 1.65986613E8 -2.98E7 -0.51 -0.4739 -0.8859 3063265 Maybridge4_000407 O=C1CC(=NN1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C12 compound treatment 1.97511662E8 2220000.0 0.03 1.71214336E8 -2.46E7 -0.42 -0.278 -0.6588 1343081 Maybridge4_000408 CC(C1CC1)N(C(=O)c2cc(C)c(Cl)cc2Cl)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C13 compound treatment 1.91168323E8 -4120000.0 -0.05 1.85447809E8 -1.04E7 -0.18 -0.162 -0.8766 1138226 Maybridge4_000409 COc1ccc2c(c1)nnc3n[nH]c(=O)n32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C14 compound treatment 2.04884372E8 9600000.0 0.12 1.7633578E8 -1.95E7 -0.33 -0.1506 -0.425 1419670 Maybridge4_000410 OC(=O)CNC(=O)CSc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C15 compound treatment 1.87936863E8 -7350000.0 -0.09 1.78708585E8 -1.71E7 -0.29 -0.2723 -0.8869 3063266 Maybridge4_000411 CC1=C(C#N)C(C(=C(C)N1)C#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C16 compound treatment 2.04246804E8 8960000.0 0.11 1.85448293E8 -1.04E7 -0.18 -0.046 -0.219 3178530 Maybridge4_000412 CCC1(CCCCN(C)C1=O)c2cccc(OC(=O)Nc3ccc(OC(F)(F)F)cc3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C17 compound treatment 2.10164354E8 1.49E7 0.19 1.76072631E8 -1.97E7 -0.34 -0.107 -0.2772 1346230 Maybridge4_000413 N#Cc1cccc2cccc(Sc3ccccc3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C18 compound treatment 2.04548916E8 9260000.0 0.12 1.88771322E8 -7040000.0 -0.12 -0.0031 -0.0185 1555561 Maybridge4_000414 COc1ccc(OC)c(CCCc2cc(OC)ccc2OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C19 compound treatment 1.97721272E8 2430000.0 0.03 1.84003644E8 -1.18E7 -0.2 -0.1214 -0.5936 3063267 Maybridge4_000415 CCN(CC)C(=O)Nc1ccc(OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C20 compound treatment 2.04503538E8 9220000.0 0.12 1.99089172E8 3270000.0 0.06 0.1214 0.9448 1920088 Maybridge4_000416 S=c1nc(c2ccco2)n(Cc3ccccc3)c(=S)n1/C(=N/Cc4ccccc4)/c5ccco5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C21 compound treatment 1.92208071E8 -3080000.0 -0.04 1.84122182E8 -1.17E7 -0.2 -0.1688 -0.8283 3178531 Maybridge4_000417 FC(F)(F)c1cccc(c1)c2nc3ccccn3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C22 compound treatment 1.58917093E8 -3.64E7 -0.46 1.59438342E8 -3.64E7 -0.62 -0.7629 -0.9883 3178532 Maybridge4_000418 O=C(/C=C\1/NN=C(NC1=O)c2ccccc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C23 mock treatment 2.00065586E8 4780000.0 0.06 2.07430721E8 1.16E7 0.2 0.183 0.8811 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 C24 mock treatment 2.02860849E8 7570000.0 0.09 1.92902348E8 -2910000.0 -0.05 0.0319 0.2976 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D01 compound treatment 1.72983983E8 -2.23E7 -0.28 1.70715453E8 -2.51E7 -0.43 -0.5016 -0.9784 3178533 Maybridge4_000419 CC1(C)C2(C)CCC1(OC2=O)C(=O)N3NC(=O)[C@H]([C@@H]3c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D02 compound treatment 1.89396526E8 -5890000.0 -0.07 1.81644692E8 -1.42E7 -0.24 -0.2238 -0.8825 3063268 Maybridge4_000420 FC(F)(F)c1cc(c(Br)c(c1Br)n2cccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D03 compound treatment 2.00641377E8 5350000.0 0.07 1.76890406E8 -1.89E7 -0.32 -0.1816 -0.5488 1316662 Maybridge4_000421 Clc1ccc(NC(=S)NC(Cn2ccnc2)c3ccccc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D04 compound treatment 1.63913368E8 -3.14E7 -0.39 1.6005359E8 -3.58E7 -0.61 -0.7112 -0.9772 1725083 Maybridge4_000422 Cc1c(N)c2c(cc1N3CCCC3)C(C)(C)CC2(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D05 compound treatment 1.79194507E8 -1.61E7 -0.2 1.82244407E8 -1.36E7 -0.23 -0.307 -0.9976 1718122 Maybridge4_000423 C1c2sc(Nc3ccccc3)nc2-c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D06 compound treatment 1.7145985E8 -2.38E7 -0.3 1.67555751E8 -2.83E7 -0.48 -0.5534 -0.9732 3178534 Maybridge4_000424 FC(F)(F)c1cc(cc(c1)S(=O)(=O)N=C2NCCCN2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D07 compound treatment 2.0586687E8 1.06E7 0.13 1.72598435E8 -2.32E7 -0.4 -0.1872 -0.4467 1138900 Maybridge4_000425 CC(C)(C)NC(=O)NCc1ccncc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D08 compound treatment 1.85207182E8 -1.01E7 -0.13 1.73192502E8 -2.26E7 -0.39 -0.3632 -0.8917 3178535 Maybridge4_000426 FC(F)(F)c1cc(NCN2C(=O)CCC2=O)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D09 compound treatment 1.72726395E8 -2.26E7 -0.28 1.76389364E8 -1.94E7 -0.33 -0.4353 -0.9968 3178536 Maybridge4_000427 COc1cccc(NC2=C(C#N)C(=O)NC(S2)c3cccc(OC)c3O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D10 compound treatment 1.87737076E8 -7550000.0 -0.09 1.75377848E8 -2.04E7 -0.35 -0.3143 -0.8673 3063269 Maybridge4_000428 Clc1ccc(cc1)S(=O)(=O)CS(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D11 compound treatment 1.93125948E8 -2160000.0 -0.03 1.7843839E8 -1.74E7 -0.3 -0.2295 -0.7684 1023491 Maybridge4_000429 Oc1ccc(Br)cc1C2Nc3ccccc3S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D12 compound treatment 2.03733219E8 8450000.0 0.11 1.8891097E8 -6900000.0 -0.12 -0.0086 -0.0545 3178537 Maybridge4_000430 C/C(=N\O)/c1nnn(c1C)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D13 compound treatment 1.5954984E8 -3.57E7 -0.45 1.43305357E8 -5.25E7 -0.9 -0.9526 -0.9484 1381610 Maybridge4_000431 CC1(C)C2CCC(C2)C1(C)NC(=S)NCC3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D14 compound treatment 1.85710839E8 -9580000.0 -0.12 1.71222492E8 -2.46E7 -0.42 -0.3826 -0.874 3178538 Maybridge4_000432 FC(F)(F)c1cccc(CS(=O)(=O)Cc2cccc(c2)C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D15 compound treatment 1.88613093E8 -6670000.0 -0.08 1.77558197E8 -1.83E7 -0.31 -0.2802 -0.866 1650135 Maybridge4_000433 Cc1c(C)c(C)c(C(=O)c2ccccc2C(=O)NCc3cccnc3)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D16 compound treatment 1.98091238E8 2800000.0 0.04 1.77812067E8 -1.8E7 -0.31 -0.193 -0.6224 1002759 Maybridge4_000434 OC(C(O)C(O)c1nc2ccccc2[nH]1)C(O)c3nc4ccccc4[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D17 compound treatment 1.80557862E8 -1.47E7 -0.18 1.69855908E8 -2.6E7 -0.44 -0.4449 -0.9244 1658002 Maybridge4_000435 Cc1c(C)c(C)c(CSC2CC(=O)N(C2=O)c3ccccc3)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D18 compound treatment 1.64812363E8 -3.05E7 -0.38 1.65968619E8 -2.98E7 -0.51 -0.6316 -0.9898 3062531 Maybridge4_000436 Clc1ccc(cc1Cl)S(=O)(=O)NC(=N)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D19 compound treatment 2.00921506E8 5630000.0 0.07 1.8891117E8 -6900000.0 -0.12 -0.0336 -0.2439 2117992 Maybridge4_000437 COc1cccc(/C=N/O)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D20 compound treatment 2.0020173E8 4910000.0 0.06 1.82801141E8 -1.3E7 -0.22 -0.1139 -0.4929 1204180 Maybridge4_000438 Clc1ccc(cc1Cl)S(=O)(=O)NCCc2c[nH]c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D21 compound treatment 2.02078468E8 6790000.0 0.09 2.3472728E8 3.89E7 0.67 0.5312 0.7911 3062533 Maybridge4_000439 CS/C(=N\S(=O)(=O)c1ccccc1)/N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D22 compound treatment 1.91244348E8 -4040000.0 -0.05 1.80329034E8 -1.55E7 -0.27 -0.2233 -0.8274 1417838 Maybridge4_000440 COC(=O)CC1(Oc2ccc(Br)cc2C(=O)N1c3ccc(F)cc3F)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D23 mock treatment 1.85841495E8 -9450000.0 -0.12 1.79813097E8 -1.6E7 -0.27 -0.2775 -0.9297 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 D24 mock treatment 1.75299942E8 -2.0E7 -0.25 1.6567292E8 -3.01E7 -0.52 -0.5421 -0.9451 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E01 compound treatment 1.59851451E8 -3.54E7 -0.44 1.79842668E8 -1.6E7 -0.27 -0.5077 -0.9727 3062534 Maybridge4_000441 Cn1nc(OC(C)(C)C(=O)Oc2ccc(Cl)cc2Cl)cc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E02 compound treatment 1.89449392E8 -5840000.0 -0.07 1.93180769E8 -2630000.0 -0.05 -0.0837 -0.9728 1024184 Maybridge4_000442 CCC(=O)c1ccc(OC)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E03 compound treatment 1.89105173E8 -6180000.0 -0.08 2.03880838E8 8070000.0 0.14 0.0428 0.2702 1519339 Maybridge4_000443 Cc1ccc(Oc2ncccc2NC(=O)CSc3ccccn3)c4CCCc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E04 compound treatment 2.20917686E8 2.56E7 0.32 2.18756529E8 2.29E7 0.39 0.505 0.9951 3062535 Maybridge4_000444 Cc1cc(=O)n(CCO)c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E05 compound treatment 2.39557673E8 4.43E7 0.56 2.23672852E8 2.79E7 0.48 0.7299 0.9971 3178539 Maybridge4_000445 OC(=O)CC(C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E06 compound treatment 2.66097067E8 7.08E7 0.89 2.42304762E8 4.65E7 0.8 1.1908 0.9985 1643916 Maybridge4_000446 O=C(N1CCCCC1)c2cccc3Cc4ccccc4-c32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E07 compound treatment 2.47918938E8 5.26E7 0.66 2.21170196E8 2.54E7 0.43 0.7738 0.9793 3178540 Maybridge4_000447 OC(=O)c1oc(C(=O)O)c(OCc2ccccc2)c1OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E08 compound treatment 2.34857745E8 3.96E7 0.5 2.26633615E8 3.08E7 0.53 0.724 0.9995 3062536 Maybridge4_000448 O=C(Oc1ccccc1)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E09 compound treatment 2.59822005E8 6.45E7 0.81 2.277791E8 3.2E7 0.55 0.9593 0.9818 1039079 Maybridge4_000449 OC(=O)c1cccc(Cl)c1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E10 compound treatment 2.51807353E8 5.65E7 0.71 2.06095568E8 1.03E7 0.18 0.6258 0.8566 1423015 Maybridge4_000450 CC(=O)N[C@@H](Cc1ccccc1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E11 compound treatment 2.15379652E8 2.01E7 0.25 2.38044248E8 4.22E7 0.72 0.6894 0.9005 3178542 Maybridge4_000451 OC(Cn1ccccc1=N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E12 compound treatment 2.76374476E8 8.11E7 1.02 2.58758662E8 6.29E7 1.08 1.4812 0.9996 3062537 Maybridge4_000452 CC(C1CC1)N(C(=O)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E13 compound treatment 2.54924326E8 5.96E7 0.75 2.38733904E8 4.29E7 0.73 1.0485 1.0 1704451 Maybridge4_000453 CN(C)C(=O)c1cccc2C(=O)c3ccccc3-c21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E14 compound treatment 2.62301203E8 6.7E7 0.84 2.50147466E8 5.43E7 0.93 1.2521 0.9987 3178543 Maybridge4_000454 CC(C)(C)C(=O)Nc1ccn([C@H]2C[C@H](O)[C@@H](COC(=O)C(C)(C)C)O2)c(=O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E15 compound treatment 2.557268E8 6.04E7 0.76 1.78541516E8 -1.73E7 -0.3 0.327 0.4019 3062540 Maybridge4_000455 COc1ccc2c(OC)ccc3C(=O)C=Cc1c32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E16 compound treatment 2.61896871E8 6.66E7 0.84 2.43599179E8 4.78E7 0.82 1.1692 0.9999 1289531 Maybridge4_000456 Clc1ccc(cc1)C(=O)OC2CN3CCC2CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E17 compound treatment 2.47059905E8 5.18E7 0.65 2.48068206E8 5.23E7 0.89 1.0917 0.9876 1672892 Maybridge4_000457 CNC(=O)c1ccccc1S(=O)c2cccc3cccc(C(=O)O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E18 compound treatment 2.66051392E8 7.08E7 0.89 2.53084053E8 5.73E7 0.98 1.3209 0.9988 3062541 Maybridge4_000458 COc1ccc(OC)c(CCCCc2cc(OC)ccc2OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E19 compound treatment 2.35616691E8 4.03E7 0.51 2.93614196E8 9.78E7 1.67 1.5415 0.8814 3178544 Maybridge4_000459 Clc1ccc(S/C=C/C(=O)c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E20 compound treatment 2.63275399E8 6.8E7 0.85 2.58880932E8 6.31E7 1.08 1.3664 0.9932 3062542 Maybridge4_000460 C/C(=N\O)/C1(CC2(C)CC3(C)CC(C)(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E21 compound treatment 2.51020026E8 5.57E7 0.7 2.36448782E8 4.06E7 0.7 0.9862 1.0 3178545 Maybridge4_000461 CC(=O)OC[C@H]1O[C@@H](Nc2ccc(C)cc2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E22 compound treatment 2.89088555E8 9.38E7 1.18 2.42511372E8 4.67E7 0.8 1.3973 0.9823 3062543 Maybridge4_000462 CC1(C)N(O)C(NC1=S)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E23 mock treatment 2.38686746E8 4.34E7 0.54 2.22226486E8 2.64E7 0.45 0.7047 0.9957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 E24 mock treatment 2.22421879E8 2.71E7 0.34 2.2137309E8 2.56E7 0.44 0.5501 0.9923 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F01 compound treatment 2.40058766E8 4.48E7 0.56 2.27069394E8 3.13E7 0.54 0.7755 0.9997 3178546 Maybridge4_000463 Fc1ccc2CC(=O)C(Cc2c1)C3=Cc4ccc(F)cc4CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F02 compound treatment 1.66640675E8 -2.86E7 -0.36 2.75810998E8 8.0E7 1.37 0.7142 0.5045 1526672 Maybridge4_000464 COc1ccc(CCNC(=O)c2nc3ccccc3c(=O)n2n4cccc4)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F03 compound treatment 2.35004701E8 3.97E7 0.5 2.62517855E8 6.67E7 1.14 1.1597 0.9309 3062544 Maybridge4_000465 CC(OC(=O)c1cccc(Cl)c1)c2ccc[n+](C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F04 compound treatment 2.57085582E8 6.18E7 0.78 2.63085769E8 6.73E7 1.15 1.3624 0.9815 1352177 Maybridge4_000466 CSc1cccc(NC(=S)Nc2cc3c(c(N)c2C)C(C)(C)CC3(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F05 compound treatment 3.077398E8 1.12E8 1.41 1.72643969E8 -2.32E7 -0.4 0.717 0.4893 3062545 Maybridge4_000467 CC(C=C1C(=O)NC(=O)NC1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F06 compound treatment 2.22146777E8 2.69E7 0.34 2.30029342E8 3.42E7 0.59 0.6524 0.9655 3062546 Maybridge4_000468 SC1=NC2(CCCC2)NN1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F07 compound treatment 2.57618562E8 6.23E7 0.78 2.55708967E8 5.99E7 1.03 1.2779 0.9911 3178547 Maybridge4_000469 C(c1ccc(/N=C/c2ccccn2)cc1)c3ccc(/N=C/c4ccccn4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F08 compound treatment 1.93557135E8 -1730000.0 -0.02 2.5141064E8 5.56E7 0.95 0.6576 0.6908 1528873 Maybridge4_000470 O=C1CCC(=O)N1CNc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F09 compound treatment 1.95562814E8 275000.0 0.0 1.4652497E8 -4.93E7 -0.84 -0.5942 -0.7042 1318293 Maybridge4_000471 CC(C)(C)C(=O)Nc1ccccc1C(=O)NCc2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F10 compound treatment 2.4314186E8 4.79E7 0.6 2.56320954E8 6.05E7 1.04 1.1569 0.9664 3178548 Maybridge4_000472 Clc1ccc(SCc2ccc(NC(=O)Nc3cccc(Cl)c3)o2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F11 compound treatment 2.54119176E8 5.88E7 0.74 2.62566164E8 6.68E7 1.14 1.3298 0.9776 3062547 Maybridge4_000473 NC(=N)Nc1nc(cs1)c2ccc(cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F12 compound treatment 2.64781244E8 6.95E7 0.87 2.44719949E8 4.89E7 0.84 1.2084 0.9998 3178625 Maybridge4_000474 CS/C(=C(/C#N)\C(=O)c1cccs1)/Nc2cccc(Cl)c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F13 compound treatment 2.45961812E8 5.07E7 0.64 2.43769734E8 4.8E7 0.82 1.03 0.992 3178626 Maybridge4_000475 OC(Cc1ccccc1)(c2ccccc2)c3ccccc3NC(=S)NC4CC5CC4C=C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F14 compound treatment 2.88216275E8 9.29E7 1.17 2.63214831E8 6.74E7 1.15 1.6401 1.0 3062548 Maybridge4_000476 Cc1nnsc1C(=O)Nc2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F15 compound treatment 2.49582253E8 5.43E7 0.68 2.33153236E8 3.73E7 0.64 0.9336 0.9995 1004988 Maybridge4_000477 ON=C(Cc1ccccc1)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F16 compound treatment 2.46258214E8 5.1E7 0.64 2.49897957E8 5.41E7 0.93 1.1068 0.9837 3178627 Maybridge4_000478 Cc1onc(c1C(=O)NC(=S)N2CCOCC2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F17 compound treatment 2.67941872E8 7.27E7 0.91 2.49090532E8 5.33E7 0.91 1.2893 1.0 3062549 Maybridge4_000479 NC(=O)Nc1ccc(cc1)/C(=C/c2ccncc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F18 compound treatment 2.51283148E8 5.6E7 0.7 2.42760787E8 4.69E7 0.8 1.0649 0.9978 3062550 Maybridge4_000480 CN(C)C(=S)SCc1c(C)c(C)c(C)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F19 compound treatment 2.61623126E8 6.63E7 0.83 2.49386182E8 5.36E7 0.92 1.2369 0.9988 3178628 Maybridge4_000481 COc1ccc(cc1)n2c(CC#N)nnc2SCc3c(C)c(C)c(C)c(C)c3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F20 compound treatment 2.32750214E8 3.75E7 0.47 2.30583936E8 3.48E7 0.6 0.7532 0.9932 3178629 Maybridge4_000482 CC1(C)ON(C(=N1)NC(=O)NC(=O)c2ccccc2Cl)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F21 compound treatment 2.38594097E8 4.33E7 0.54 2.47530219E8 5.17E7 0.89 1.0101 0.9725 3062551 Maybridge4_000483 O=S(=O)(/N=C/1\NCC2CCCC2N1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F22 compound treatment 2.43647901E8 4.84E7 0.61 2.5622624E8 6.04E7 1.03 1.1602 0.9677 3178630 Maybridge4_000484 CC(CO)(CO)NC(=S)Nc1ccc(F)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F23 mock treatment 2.00422379E8 5130000.0 0.06 2.33372615E8 3.76E7 0.64 0.5002 0.7741 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 F24 mock treatment 2.00780183E8 5490000.0 0.07 2.11682332E8 1.59E7 0.27 0.2408 0.8592 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G01 compound treatment 1.32863823E8 -6.24E7 -0.78 1.90395527E8 -5420000.0 -0.09 -0.6193 -0.7854 1441207 Maybridge4_000485 CC(C)(C)c1cc2[nH]c(=N)[nH]c(=N)n2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G02 compound treatment 1.54937379E8 -4.04E7 -0.51 1.95887782E8 73600.0 0.0 -0.357 -0.7053 1390371 Maybridge4_000486 O=c1c(Cc2ccccc2OCc3ccccc3)coc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G03 compound treatment 1.64989597E8 -3.03E7 -0.38 2.00660935E8 4850000.0 0.08 -0.2101 -0.54 3062552 Maybridge4_000487 COc1ccccc1C2OC(=O)C[C@H]2C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G04 compound treatment 2.45276932E8 5.0E7 0.63 2.47451785E8 5.16E7 0.88 1.0685 0.9859 1630105 Maybridge4_000488 Brc1ccc(cc1)C(=O)c2cc3OCCCOc3cc2Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G05 compound treatment 2.34914947E8 3.96E7 0.5 2.66897872E8 7.11E7 1.22 1.2119 0.922 1255736 Maybridge4_000489 COc1cc(OC)nc(NCC(NC(=O)c2ccccc2)C(=O)N)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G06 compound treatment 2.53277377E8 5.8E7 0.73 2.63285033E8 6.75E7 1.15 1.3311 0.9752 1191076 Maybridge4_000490 CNc1cc(=O)n(c2ccccc2)c(=O)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G07 compound treatment 2.56098029E8 6.08E7 0.76 2.5718208E8 6.14E7 1.05 1.2822 0.9876 1024944 Maybridge4_000491 CCOC(=O)c1oc(C(=O)OCC)c(O)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G08 compound treatment 2.36882687E8 4.16E7 0.52 2.45242793E8 4.94E7 0.85 0.9673 0.973 3062592 Maybridge4_000492 CC(C)(C)c1ccc2cc(C#N)c(C#N)cc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G09 compound treatment 2.31211931E8 3.59E7 0.45 2.3421025E8 3.84E7 0.66 0.7834 0.9831 3062593 Maybridge4_000493 O=C1N(CCCCN2C(=O)c3ccccc3S2(=O)=O)S(=O)(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G10 compound treatment 2.33862157E8 3.86E7 0.48 2.44667019E8 4.89E7 0.84 0.9335 0.9662 3062594 Maybridge4_000494 Cc1ccc(NC(=O)N(C2=NCC(C)(C)S2)c3ccc(F)c(Cl)c3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G11 compound treatment 2.33112922E8 3.78E7 0.47 2.5225392E8 5.64E7 0.97 1.0187 0.9464 1051499 Maybridge4_000495 CC(O)c1ccc2ccccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G12 compound treatment 2.56279973E8 6.1E7 0.77 2.57319324E8 6.15E7 1.05 1.2855 0.9877 1332464 Maybridge4_000496 OCCOC(=O)c1cccc2C(=O)c3ccccc3-c21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G13 compound treatment 2.22174998E8 2.69E7 0.34 2.3412985E8 3.83E7 0.66 0.7023 0.9522 1397918 Maybridge4_000497 CCCN(CCC)C(=O)c1cccc2C(=O)c3ccccc3-c21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G14 compound treatment 2.41664107E8 4.64E7 0.58 2.40221251E8 4.44E7 0.76 0.9489 0.9913 3178631 Maybridge4_000498 CC(C)(C)C(=O)OC[C@H]1O[C@H](C[C@@H]1OC(=O)C(C)(C)C)n2cnc3c(N)ncnc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G15 compound treatment 2.51524433E8 5.62E7 0.71 2.84033745E8 8.82E7 1.51 1.5667 0.9399 3062595 Maybridge4_000499 O=C(OC1=CC(=O)c2cccc3cccc1c23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G16 compound treatment 2.2936282E8 3.41E7 0.43 2.46191335E8 5.04E7 0.86 0.912 0.9476 1645132 Maybridge4_000500 O=C(NC1CCN(Cc2cccc3ccccc23)CC1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G17 compound treatment 2.32907892E8 3.76E7 0.47 2.34792047E8 3.9E7 0.67 0.8055 0.9856 1430296 Maybridge4_000501 OCc1cccc2cccc(S(=O)c3cccc4cccc(C(=O)O)c34)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G18 compound treatment 2.57537624E8 6.22E7 0.78 2.58579261E8 6.28E7 1.07 1.3119 0.9877 1284168 Maybridge4_000502 Brc1ccc(Cc2csc3ccccc3c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G19 compound treatment 2.39949295E8 4.47E7 0.56 2.61959857E8 6.61E7 1.13 1.1968 0.9474 3178632 Maybridge4_000503 FC(F)(F)Oc1ccccc1NC(=O)CC(=O)Nc2ccccc2OC(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G20 compound treatment 2.43283414E8 4.8E7 0.6 2.40274166E8 4.45E7 0.76 0.9639 0.9933 1186920 Maybridge4_000504 NNC(=O)C1(CCCC2CCC1)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G21 compound treatment 2.27054844E8 3.18E7 0.4 2.28352983E8 3.25E7 0.56 0.6756 0.9865 3062596 Maybridge4_000505 FC1(C(=O)Nc2c(Cl)c(Cl)ccc2C1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G22 compound treatment 2.37907785E8 4.26E7 0.53 2.59627139E8 6.38E7 1.09 1.1505 0.946 3178633 Maybridge4_000506 CC(C)(C)OC(=O)Cn1ccc(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G23 mock treatment 2.05398241E8 1.01E7 0.13 2.19840713E8 2.4E7 0.41 0.3805 0.8841 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 G24 mock treatment 2.32937035E8 3.76E7 0.47 2.33657043E8 3.78E7 0.65 0.792 0.9879 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H01 compound treatment 2.24416821E8 2.91E7 0.37 2.53348114E8 5.75E7 0.98 0.9548 0.9089 3178634 Maybridge4_000507 O/N=C(/C1CC2CCC1CC2)\c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H02 compound treatment 2.29670568E8 3.44E7 0.43 2.70599082E8 7.48E7 1.28 1.2102 0.8959 1138209 Maybridge4_000508 N1C(c2cccn2-c3ccccc13)c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H03 compound treatment 2.13693118E8 1.84E7 0.23 2.50363682E8 5.45E7 0.93 0.8235 0.8562 1326325 Maybridge4_000509 Cc1c(C)c(C)c(CN2C(=O)c3ccccc3C2=O)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H04 compound treatment 1.88997296E8 -6290000.0 -0.08 2.60842782E8 6.5E7 1.11 0.7313 0.6553 3062597 Maybridge4_000510 Cc1c(cc2c(c1n3cccc3)C(C)(C)CC2(C)C)N4CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H05 compound treatment 2.2565136E8 3.04E7 0.38 2.7080534E8 7.5E7 1.28 1.177 0.879 3178635 Maybridge4_000511 Fc1ccc(cc1)C(=O)CSc2nsc(SCC(=O)c3ccc(F)cc3)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H06 compound treatment 2.0444131E8 9150000.0 0.11 2.34685583E8 3.89E7 0.67 0.5517 0.8171 3178636 Maybridge4_000512 CC(C)C1CCC(C)CC1NC(=S)Nc2cccc(F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H07 compound treatment 2.27713815E8 3.24E7 0.41 2.39263785E8 4.34E7 0.74 0.8136 0.9597 1248377 Maybridge4_000513 CC1CCCCN1C(=S)Nc2ccc(cc2)S(=O)(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H08 compound treatment 2.30389921E8 3.51E7 0.44 2.49267795E8 5.35E7 0.92 0.9584 0.9438 3178637 Maybridge4_000514 COc1cccc(OC)c1C(=O)Nc2cc(c(Cl)cc2OC)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H09 compound treatment 2.5554257E8 6.03E7 0.76 2.53443642E8 5.76E7 0.99 1.232 0.9914 1054040 Maybridge4_000515 CC(C)C1=NNC(=O)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H10 compound treatment 2.37336689E8 4.2E7 0.53 2.45228996E8 4.94E7 0.85 0.9711 0.9742 1253333 Maybridge4_000516 Nc1nc2c(nnn2c3ccccc13)C(=O)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H11 compound treatment 2.60722002E8 6.54E7 0.82 2.6480192E8 6.9E7 1.18 1.4155 0.9842 1700266 Maybridge4_000517 COc1ccc(CCNC(=S)NCCc2ccccc2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H12 compound treatment 2.48832107E8 5.35E7 0.67 2.4592518E8 5.01E7 0.86 1.0815 0.9927 3178638 Maybridge4_000518 O/N=C(\C#N)/C(=O)c1ccco1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H13 compound treatment 2.57725432E8 6.24E7 0.78 2.64393389E8 6.86E7 1.17 1.3839 0.9807 1672819 Maybridge4_000519 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H14 compound treatment 2.59591951E8 6.43E7 0.81 2.86105377E8 9.03E7 1.55 1.6633 0.954 3178639 Maybridge4_000520 Fc1cc(F)c(NC(=S)N2CCOCC2)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H15 compound treatment 2.58238582E8 6.3E7 0.79 2.68303469E8 7.25E7 1.24 1.4358 0.9762 1546700 Maybridge4_000521 Cc1c(C)c(C)c(C(=O)c2ccccc2C(=O)NN)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H16 compound treatment 2.76058663E8 8.08E7 1.01 2.73788686E8 7.8E7 1.33 1.6603 0.9908 3062598 Maybridge4_000522 Fc1cccc(NCc2cccs2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H17 compound treatment 2.66424855E8 7.11E7 0.89 2.74228885E8 7.84E7 1.34 1.5802 0.9803 3178640 Maybridge4_000523 NC(=O)Nc1ccc(cc1)/C(=C/c2ccc(Cl)c(Cl)c2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H18 compound treatment 2.52786585E8 5.75E7 0.72 2.27364424E8 3.16E7 0.54 0.8919 0.9898 3062599 Maybridge4_000524 CN(C)C(=S)SCC(=O)c1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H19 compound treatment 2.44655257E8 4.94E7 0.62 2.63004018E8 6.72E7 1.15 1.2512 0.9578 1221296 Maybridge4_000525 Cc1cc(C)c2-c3[nH]c(nc3C(C)(C)Cc2c1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H20 compound treatment 2.09871094E8 1.46E7 0.18 2.35584749E8 3.98E7 0.68 0.6107 0.8664 1556252 Maybridge4_000526 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H21 compound treatment 2.55262027E8 6.0E7 0.75 2.4287713E8 4.71E7 0.81 1.1016 0.9994 3062600 Maybridge4_000527 CC1CN/C(=N/S(=O)(=O)c2ccccc2)/N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H22 compound treatment 2.40346361E8 4.51E7 0.57 2.54453472E8 5.86E7 1.0 1.1095 0.9631 1621149 Maybridge4_000528 CC1CC(C)CN(C1)c2ccc(NS(=O)(=O)c3ccccc3)cc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H23 mock treatment 2.33724267E8 3.84E7 0.48 2.39430026E8 4.36E7 0.75 0.8689 0.9776 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 H24 mock treatment 2.2605069E8 3.08E7 0.39 2.42940205E8 4.71E7 0.81 0.8433 0.943 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I01 compound treatment 6.6058246E7 -1.29E8 -1.62 1.33598211E8 -6.22E7 -1.07 -1.8994 -0.9792 3062601 Maybridge4_000529 Cc1ccc(Oc2ncc(cc2Cl)C(F)(F)F)c3CCCc31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I02 compound treatment 7.0460009E7 -1.25E8 -1.57 1.36525375E8 -5.93E7 -1.01 -1.8249 -0.978 3178641 Maybridge4_000530 CCOC(=O)CSc1nnc(S)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I03 compound treatment 6.7603889E7 -1.28E8 -1.6 1.22545225E8 -7.33E7 -1.25 -2.0195 -0.9927 3178642 Maybridge4_000531 Cc1nc(cs1)c2cc(C#N)c(SCCNS(=O)(=O)c3ccc(cc3)C(C)(C)C)nc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I04 compound treatment 1.12016887E8 -8.33E7 -1.04 1.71399696E8 -2.44E7 -0.42 -1.0342 -0.9192 1202864 Maybridge4_000532 Cc1ccc(cc1)C(=O)C2C(=O)N(C(=O)N(C2=O)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I05 compound treatment 1.52116031E8 -4.32E7 -0.54 2.24907253E8 2.91E7 0.5 -0.0308 -0.0419 1219965 Maybridge4_000533 Cc1nn(nc1C(=O)ON2C(=O)C3C4OC(C=C4)C3C2=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I06 compound treatment 1.75395175E8 -1.99E7 -0.25 2.12994312E8 1.72E7 0.29 0.0315 0.0817 3062602 Maybridge4_000534 COc1ccc(/C=C\2/C(Oc3ccccc3C2=O)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I07 compound treatment 1.75356999E8 -1.99E7 -0.25 2.07549024E8 1.17E7 0.2 -0.0348 -0.1084 1277364 Maybridge4_000535 CCOC(=O)c1c(O)c(O)c(C(=O)OCC)n1c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I08 compound treatment 1.59694788E8 -3.56E7 -0.45 2.10985707E8 1.52E7 0.26 -0.1321 -0.2557 1178381 Maybridge4_000536 Fc1ccc2[nH]c3CCN(Cc3c2c1)C(=O)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I09 compound treatment 1.81587798E8 -1.37E7 -0.17 2.39411354E8 4.36E7 0.75 0.4062 0.5304 1497959 Maybridge4_000537 CC(C)C1CCC(C)CC1NC(=O)c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I10 compound treatment 1.60736086E8 -3.46E7 -0.43 2.15450705E8 1.96E7 0.34 -0.0688 -0.1254 1039563 Maybridge4_000538 Clc1ccc2oc(cc(=O)c2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I11 compound treatment 1.78030634E8 -1.73E7 -0.22 2.02364324E8 6550000.0 0.11 -0.0738 -0.3027 1035419 Maybridge4_000539 O=C(c1ccccc1)c2ccc(cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I12 compound treatment 1.82877849E8 -1.24E7 -0.16 2.056494E8 9840000.0 0.17 0.009 0.0391 3178724 Maybridge4_000540 Sc1nn(c2ccc(Cl)cc2)c(=S)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I13 compound treatment 1.7593008E8 -1.94E7 -0.24 1.98921575E8 3110000.0 0.05 -0.1341 -0.5394 1060199 Maybridge4_000541 CNC(=O)c1cccc2C(=O)c3ccccc3-c21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I14 compound treatment 1.69340883E8 -2.59E7 -0.33 2.1967342E8 2.39E7 0.41 0.0586 0.1123 3178725 Maybridge4_000542 NNC(=O)c1cc(n[nH]1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I15 compound treatment 2.25781537E8 3.05E7 0.38 2.28425532E8 3.26E7 0.56 0.6652 0.983 1005720 Maybridge4_000543 CN(C)c1ccc(Cc2ccc(cc2)N(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I16 compound treatment 1.89581887E8 -5710000.0 -0.07 2.20708022E8 2.49E7 0.43 0.2507 0.5802 1587057 Maybridge4_000544 COc1ccccc1C2CCN(Cc3cccc4ccccc34)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I17 compound treatment 1.62318424E8 -3.3E7 -0.41 1.85296252E8 -1.05E7 -0.18 -0.4198 -0.9306 2075442 Maybridge4_000545 CN1[S+](c2ccccc2C(=O)O)c3cccc4cccc(C1=O)c34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I18 compound treatment 1.78160133E8 -1.71E7 -0.21 2.15195345E8 1.94E7 0.33 0.0827 0.2091 3178726 Maybridge4_000546 Nc1ccccc1SC(CC(=O)c2ccc(Br)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I19 compound treatment 1.87860765E8 -7430000.0 -0.09 1.84651909E8 -1.12E7 -0.19 -0.201 -0.9455 1287387 Maybridge4_000547 OCC(O)Cn1c2ccc(Br)cc2c3cc(Br)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I20 compound treatment 2.01835351E8 6550000.0 0.08 2.30956594E8 3.51E7 0.6 0.4834 0.7963 1441014 Maybridge4_000548 OC(=O)C1(CCCC2(CCC1)C(=O)O)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I21 compound treatment 2.18949009E8 2.37E7 0.3 2.07099564E8 1.13E7 0.19 0.3465 0.9784 1343250 Maybridge4_000549 O=C1C(C2c3ccccc3Oc4ccccc24)C(=O)c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I22 compound treatment 1.80928998E8 -1.44E7 -0.18 2.34697475E8 3.89E7 0.67 0.3433 0.4978 3062641 Maybridge4_000550 OC[C@H]1O[C@@H](Oc2c[nH]c3ccc(Br)c(Cl)c23)[C@H](O)[C@@H](O)[C@H]1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I23 mock treatment 2.42561084E8 4.73E7 0.59 2.43401585E8 4.76E7 0.81 0.9953 0.9878 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 I24 mock treatment 2.02290067E8 7000000.0 0.09 1.91818407E8 -4000000.0 -0.07 0.0137 0.1235 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J01 compound treatment 2.16844799E8 2.16E7 0.27 2.05175168E8 9360000.0 0.16 0.3045 0.9688 3062642 Maybridge4_000551 COC(=O)C1CCC(=O)C(C1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J02 compound treatment 2.37278736E8 4.2E7 0.53 1.71623435E8 -2.42E7 -0.41 0.0797 0.1189 1601179 Maybridge4_000552 Oc1ccc2ccccc2c1C3Nc4ccccc4-n5cccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J03 compound treatment 2.18768958E8 2.35E7 0.29 2.28226221E8 3.24E7 0.55 0.6006 0.9561 3062643 Maybridge4_000553 Cc1c(C)c(C)c(CN2CCCCC2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J04 compound treatment 1.93202195E8 -2090000.0 -0.03 1.56693127E8 -3.91E7 -0.67 -0.492 -0.7342 3062644 Maybridge4_000554 CC(=O)Nc1s/c(=N\c2ccc(C)c(C)c2)/n(C(=O)C)c1c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J05 compound treatment 2.42469356E8 4.72E7 0.59 2.23910111E8 2.81E7 0.48 0.7586 0.9947 1342204 Maybridge4_000555 O=S(=O)(N1CCCCC1)c2ccc(NC(=S)Nc3ccc4OCOc4c3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J06 compound treatment 2.04838214E8 9550000.0 0.12 2.08801329E8 1.3E7 0.22 0.2419 0.9579 3062645 Maybridge4_000556 Clc1ccc(Cl)c(NC(=S)NC(=N)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J07 compound treatment 1.90438179E8 -4850000.0 -0.06 2.13022724E8 1.72E7 0.29 0.1653 0.5495 3178727 Maybridge4_000557 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc(CC3C(=O)Nc4ccccc34)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J08 compound treatment 1.77357266E8 -1.79E7 -0.22 1.90535233E8 -5280000.0 -0.09 -0.2229 -0.9197 3178728 Maybridge4_000558 CN1CCC2(C(C1)N=NN2c3cc(cc(c3)C(F)(F)F)C(F)(F)F)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J09 compound treatment 2.145204E8 1.92E7 0.24 1.99666517E8 3850000.0 0.07 0.2172 0.8685 3062646 Maybridge4_000559 Cc1cc(C)c(C(=O)Nc2cccc(c2)C(F)(F)F)c3CC(C)(C)C(=O)c31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J10 compound treatment 1.60595191E8 -3.47E7 -0.44 1.90076351E8 -5740000.0 -0.1 -0.3772 -0.8454 1734956 Maybridge4_000560 Nc1nc2c(nnn2c3ccccc13)c4ccc(Br)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J11 compound treatment 1.82825015E8 -1.25E7 -0.16 1.97279492E8 1470000.0 0.03 -0.0928 -0.5862 3178729 Maybridge4_000561 Cc1c(C)c(C)c(C(O)c2ccccc2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J12 compound treatment 2.01396787E8 6110000.0 0.08 1.99298535E8 3480000.0 0.06 0.0964 0.9923 3178730 Maybridge4_000562 COc1ccc(cc1)c2c(C#N)nnn2c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J13 compound treatment 1.97317793E8 2030000.0 0.03 2.16073766E8 2.03E7 0.35 0.2632 0.757 1646858 Maybridge4_000563 CCN1C(C(CCC1=O)C(=O)O)c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J14 compound treatment 2.2568881E8 3.04E7 0.38 2.10323112E8 1.45E7 0.25 0.4453 0.9784 1299644 Maybridge4_000564 Fc1cccc(NCCc2ccccn2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J15 compound treatment 2.12582642E8 1.73E7 0.22 2.39439191E8 4.36E7 0.75 0.6815 0.8763 3062647 Maybridge4_000565 CCOC(=S)SCc1c(C)c(C)c(C)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J16 compound treatment 2.03635023E8 8350000.0 0.1 1.95413182E8 -401000.0 -0.01 0.0692 0.6593 1536926 Maybridge4_000566 O=C(CC#N)NCc1cccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J17 compound treatment 2.04809267E8 9520000.0 0.12 2.47378902E8 5.16E7 0.88 0.7086 0.7955 3178731 Maybridge4_000567 Cc1onc(c1NC(=O)Nc2cccc(c2)C(F)(F)F)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J18 compound treatment 1.85557719E8 -9730000.0 -0.12 2.45004389E8 4.92E7 0.84 0.5091 0.5984 1727398 Maybridge4_000568 CCc1cccc(C(C)C)c1NS(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J19 compound treatment 1.99936076E8 4650000.0 0.06 2.31721077E8 3.59E7 0.61 0.4759 0.7707 3062649 Maybridge4_000569 Nn1c(nc2ccccc2c1=O)C(=O)NCc3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J20 compound treatment 2.02508088E8 7220000.0 0.09 2.44922726E8 4.91E7 0.84 0.6585 0.7788 3178732 Maybridge4_000570 CC1CCCCN1CCCNC(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J21 compound treatment 1.98649435E8 3360000.0 0.04 2.12949299E8 1.71E7 0.29 0.2372 0.8005 3062650 Maybridge4_000571 Clc1ccc(SCc2ccc(C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J22 compound treatment 1.94532645E8 -755000.0 -0.01 2.23802297E8 2.8E7 0.48 0.3321 0.693 3178733 Maybridge4_000572 CC1CN(CC(C)O1)c2ccc(NC(=O)c3ccco3)cc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J23 mock treatment 1.91726131E8 -3560000.0 -0.04 2.1379145E8 1.8E7 0.31 0.186 0.5982 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 J24 mock treatment 1.99694274E8 4410000.0 0.06 2.16266719E8 2.05E7 0.35 0.2866 0.8087 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K01 compound treatment 9.1568042E7 -1.04E8 -1.3 6.637243E7 -1.29E8 -2.22 -2.4868 -0.9678 1258100 Maybridge4_000573 OC(=O)C1CC1C(=O)Nc2ccc(Oc3ccc(Cl)cc3C4CCCCC4)nc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K02 compound treatment 1.12150452E8 -8.31E7 -1.04 8.7324097E7 -1.08E8 -1.86 -2.0506 -0.9628 3062651 Maybridge4_000574 CCOC(=O)CCSc1nnc(S)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K03 compound treatment 9.4203042E7 -1.01E8 -1.27 7.2716893E7 -1.23E8 -2.11 -2.3867 -0.9705 1465836 Maybridge4_000575 Fc1ccc(COc2ccc(cc2)C(=O)CSc3ccccn3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K04 compound treatment 8.6813218E7 -1.08E8 -1.36 1.09696787E8 -8.61E7 -1.47 -2.0046 -0.9992 1182542 Maybridge4_000576 CC1(CC2(C)CC3(C)C1)CC(C2)(C3)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K05 compound treatment 1.04254156E8 -9.1E7 -1.14 1.36108444E8 -5.97E7 -1.02 -1.5302 -0.9985 3178734 Maybridge4_000577 OC1CCCCCCCCCCC1CCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K06 compound treatment 8.6658467E7 -1.09E8 -1.36 1.04398106E8 -9.14E7 -1.56 -2.0701 -0.9976 3062652 Maybridge4_000578 CC(C)CCNC(=O)Oc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K07 compound treatment 1.42902212E8 -5.24E7 -0.66 1.5824984E8 -3.76E7 -0.64 -0.9194 -0.9999 3178735 Maybridge4_000579 COc1ccc(OC)c2c(=O)cc(oc12)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K08 compound treatment 1.36743515E8 -5.85E7 -0.73 1.48102534E8 -4.77E7 -0.82 -1.0968 -0.9986 1674875 Maybridge4_000580 COc1ccccc1C2CCN(CC2)C(=O)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K09 compound treatment 1.32500567E8 -6.28E7 -0.79 1.60392825E8 -3.54E7 -0.61 -0.9857 -0.9916 3178736 Maybridge4_000581 CC1(C)C2CCC1(C)C(C2)NC(=O)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K10 compound treatment 1.57720922E8 -3.76E7 -0.47 1.72736405E8 -2.31E7 -0.4 -0.6126 -0.9962 1672849 Maybridge4_000582 Cc1onc(c1C(=O)N2CC(C2)Oc3ccc(Cl)cc3)c4c(F)cccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K11 compound treatment 1.53610027E8 -4.17E7 -0.52 1.45509947E8 -5.03E7 -0.86 -0.9786 -0.9714 3062653 Maybridge4_000583 Cc1cc(n[nH]c1=O)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K12 compound treatment 1.54135894E8 -4.12E7 -0.52 1.57597706E8 -3.82E7 -0.65 -0.8276 -0.9931 3062654 Maybridge4_000584 Sc1nc(c2ccccc2)n(n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K13 compound treatment 1.04672425E8 -9.06E7 -1.14 1.13768787E8 -8.2E7 -1.4 -1.7969 -0.9945 1267527 Maybridge4_000585 CC(C)CCNC(=O)c1cccc2C(=O)c3ccccc3-c21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K14 compound treatment 1.57549685E8 -3.77E7 -0.47 1.85754027E8 -1.01E7 -0.17 -0.4565 -0.9062 3062655 Maybridge4_000586 O=C1C(CCCC1c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K15 compound treatment 1.35168301E8 -6.01E7 -0.75 1.54272051E8 -4.15E7 -0.71 -1.0361 -0.9996 3178737 Maybridge4_000587 Cc1c(cnc2ccccc12)c3nnnn3c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K16 compound treatment 1.4994726E8 -4.53E7 -0.57 1.7428679E8 -2.15E7 -0.37 -0.6628 -0.9779 1175626 Maybridge4_000588 Cc1ccc(cc1)C(=O)OC2CN3CCC2CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K17 compound treatment 1.51658326E8 -4.36E7 -0.55 1.79721363E8 -1.61E7 -0.28 -0.5818 -0.9495 3178738 Maybridge4_000589 CN1[S+](c2ccccc2C1=O)c3cccc4cccc(C(=O)O)c34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K18 compound treatment 1.57754922E8 -3.75E7 -0.47 1.84765873E8 -1.1E7 -0.19 -0.4667 -0.9197 3178739 Maybridge4_000590 CC1(C)C2CCC1(C)c3nn(c(c23)C(F)(F)F)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K19 compound treatment 1.29597712E8 -6.57E7 -0.82 1.52865407E8 -4.29E7 -0.74 -1.1026 -0.9984 1361703 Maybridge4_000591 CCOC(Cn1c2ccccc2c3ccccc13)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K20 compound treatment 1.4945396E8 -4.58E7 -0.57 1.82029113E8 -1.38E7 -0.24 -0.5734 -0.9226 1031191 Maybridge4_000592 OC(=O)C1C(C2CCC1C2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K21 compound treatment 1.39890876E8 -5.54E7 -0.69 1.77977844E8 -1.78E7 -0.31 -0.7073 -0.9318 1224135 Maybridge4_000593 Cn1c(nc2ccccc12)C(C#N)C(=O)c3ccccc3I 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K22 compound treatment 1.58843813E8 -3.64E7 -0.46 1.87586316E8 -8230000.0 -0.14 -0.4229 -0.884 1062658 Maybridge4_000594 CCOC(=O)C1C(C2c3ccccc3C1c4ccccc24)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K23 mock treatment 1.39415854E8 -5.59E7 -0.7 1.12929026E8 -8.29E7 -1.42 -1.4989 -0.9471 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 K24 mock treatment 1.72684788E8 -2.26E7 -0.28 1.98059533E8 2250000.0 0.04 -0.1733 -0.6057 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L01 compound treatment 1.83189257E8 -1.21E7 -0.15 1.95877577E8 63400.0 0.0 -0.1066 -0.702 3062656 Maybridge4_000595 CCCCN(C(C)C)S(=O)(=O)c1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L02 compound treatment 1.78095587E8 -1.72E7 -0.22 2.11927387E8 1.61E7 0.28 0.0425 0.1215 3178740 Maybridge4_000596 FC(F)(F)c1cccc(c1)/C(=C/C=C/c2ccccc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L03 compound treatment 1.04386904E8 -9.09E7 -1.14 1.98558812E8 2740000.0 0.05 -0.7731 -0.6774 3062657 Maybridge4_000597 O=C1NC(=O)C(=CC2CCC=CC2)C(=O)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L04 compound treatment 1.20246908E8 -7.5E7 -0.94 1.49678594E8 -4.61E7 -0.79 -1.2241 -0.9962 1174872 Maybridge4_000598 Fc1cccc(F)c1C(=O)Nc2cccc(NC(=O)c3c(F)cccc3F)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L05 compound treatment 1.97809967E8 2520000.0 0.03 2.07701359E8 1.19E7 0.2 0.1663 0.8073 3178741 Maybridge4_000599 COc1ccc(CC/N=C/c2ccc3OCOc3c2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L06 compound treatment 1.75080742E8 -2.02E7 -0.25 1.95803674E8 -10500.0 0.0 -0.1794 -0.7076 3062658 Maybridge4_000600 FC(F)(F)c1cc(C#CCN2CCCCC2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L07 compound treatment 1.85703284E8 -9580000.0 -0.12 2.14867229E8 1.91E7 0.33 0.1456 0.4189 3178820 Maybridge4_000601 CC(C)NC(=S)N1CCCN2C1c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L08 compound treatment 1.97996551E8 2710000.0 0.03 1.95374775E8 -439000.0 -0.01 0.0187 0.5376 3062659 Maybridge4_000602 FC(F)(F)c1cccc(c1C(=O)OCC(=O)c2ccc(Cl)cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L09 compound treatment 1.80010622E8 -1.53E7 -0.19 1.87852713E8 -7960000.0 -0.14 -0.2319 -0.986 1236762 Maybridge4_000603 S=C(Nc1ccccc1)Nc2ccccc2n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L10 compound treatment 1.51094281E8 -4.42E7 -0.55 1.58498113E8 -3.73E7 -0.64 -0.8437 -0.9975 3062660 Maybridge4_000604 COc1ccc(OC)c(c1)S(=O)(=O)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L11 compound treatment 1.62063455E8 -3.32E7 -0.42 1.74158789E8 -2.17E7 -0.37 -0.5568 -0.9983 1138158 Maybridge4_000605 COc1ccc(OCCC(=O)NN)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L12 compound treatment 1.26689212E8 -6.86E7 -0.86 2.05093864E8 9280000.0 0.16 -0.4962 -0.567 3062661 Maybridge4_000606 CN(C)C(=O)c1c(C)onc1c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L13 compound treatment 1.75705602E8 -1.96E7 -0.25 1.95237088E8 -577000.0 -0.01 -0.1807 -0.7349 3178821 Maybridge4_000607 OC(Cc1ccccc1)(c2ccccc2)c3ccccc3/N=C/c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L14 compound treatment 1.84401191E8 -1.09E7 -0.14 1.98950083E8 3140000.0 0.05 -0.0586 -0.3994 3178822 Maybridge4_000608 Fc1cccc(N(Cc2cccnc2)C(=S)Nc3ccc(Cl)c(Cl)c3)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L15 compound treatment 1.87227511E8 -8060000.0 -0.1 2.08376257E8 1.26E7 0.22 0.0806 0.339 3062708 Maybridge4_000609 Cc1c(C)c(C)c(CSc2ccccn2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L16 compound treatment 1.85073894E8 -1.02E7 -0.13 2.13089613E8 1.73E7 0.3 0.1185 0.3677 3062709 Maybridge4_000610 CC(C)NC(=O)NCc1c(F)cccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L17 compound treatment 1.88286765E8 -7000000.0 -0.09 1.92617149E8 -3200000.0 -0.05 -0.1008 -0.9741 3062710 Maybridge4_000611 Cc1c(C)c(C)c(C(=O)/C=N/N)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L18 compound treatment 1.51606845E8 -4.37E7 -0.55 1.86130756E8 -9680000.0 -0.17 -0.5047 -0.8816 3062711 Maybridge4_000612 CCc1cccc(C(C)C)c1NC(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L19 compound treatment 1.62389347E8 -3.29E7 -0.41 1.87824111E8 -7990000.0 -0.14 -0.3885 -0.8937 3062712 Maybridge4_000613 COc1ccc(NC(=S)NCCCC2C=NN=C2O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L20 compound treatment 1.21224144E8 -7.41E7 -0.93 1.38389036E8 -5.74E7 -0.98 -1.3521 -0.9996 3062713 Maybridge4_000614 CC(C)(C)C1=C(C#N)C(C(=C(NC(=O)NC(=O)c2c(F)cccc2Cl)O1)C#N)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L21 compound treatment 1.89044336E8 -6240000.0 -0.08 2.1060204E8 1.48E7 0.25 0.1236 0.4665 1309274 Maybridge4_000615 Cc1cc(C)c(C(=O)Nc2ccc(C)c(C)c2)c(CC(C)(C)C(=O)O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L22 compound treatment 1.89250527E8 -6040000.0 -0.08 1.81258817E8 -1.46E7 -0.25 -0.2297 -0.8822 3178823 Maybridge4_000616 OCC(CO)(CO)NC(=S)Nc1cc(Cl)cc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L23 mock treatment 1.68018128E8 -2.73E7 -0.34 2.09790645E8 1.4E7 0.24 -0.0727 -0.1742 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 L24 mock treatment 1.80797444E8 -1.45E7 -0.18 1.93173544E8 -2640000.0 -0.05 -0.1605 -0.8568 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M01 compound treatment 6.4321583E7 -1.31E8 -1.64 5.4605827E7 -1.41E8 -2.42 -2.8709 -0.9823 1443995 Maybridge4_000617 CCCc1ccc(Oc2ccc(NC(=O)C3CC3C(=O)O)cn2)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M02 compound treatment 1.01683125E8 -9.36E7 -1.17 8.0578514E7 -1.15E8 -1.97 -2.2251 -0.9693 2105374 Maybridge4_000618 Oc1ccc(cc1)C(C#N)N2CCN(CC2)C(C#N)c3ccc(O)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M03 compound treatment 9.7914267E7 -9.74E7 -1.22 7.8321662E7 -1.17E8 -2.01 -2.2859 -0.9714 1235908 Maybridge4_000619 Cc1nc(cs1)c2cc(C#N)c(SCCC(=O)OC(C)(C)C)nc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M04 compound treatment 1.75671261E8 -1.96E7 -0.25 1.29563699E8 -6.63E7 -1.13 -0.9759 -0.841 1332220 Maybridge4_000620 COc1ccc(cc1)C(=O)NC2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M05 compound treatment 1.85858482E8 -9430000.0 -0.12 1.32572942E8 -6.32E7 -1.08 -0.8491 -0.7797 3178824 Maybridge4_000621 CN1C2CCC1CC(C2)NC(=O)Cc3ccccc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M06 compound treatment 2.012879E8 6000000.0 0.08 1.47322706E8 -4.85E7 -0.83 -0.5337 -0.6404 3062715 Maybridge4_000622 CCNC(=O)Oc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M07 compound treatment 2.05217038E8 9930000.0 0.12 1.37733194E8 -5.81E7 -0.99 -0.615 -0.6137 3062716 Maybridge4_000623 CN(C)/C=C/C(=O)c1c(O)cc(C)oc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M08 compound treatment 1.93034132E8 -2250000.0 -0.03 1.25113874E8 -7.07E7 -1.21 -0.8758 -0.7234 1250275 Maybridge4_000624 COc1ccccc1C2CCN(CC2)C(=O)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M09 compound treatment 1.85272864E8 -1.0E7 -0.13 1.30338094E8 -6.55E7 -1.12 -0.8814 -0.7815 1731106 Maybridge4_000625 COc1ccc(Br)cc1COC(=O)C2c3ccccc3Oc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M10 compound treatment 1.6497788E8 -3.03E7 -0.38 1.20366778E8 -7.54E7 -1.29 -1.1821 -0.878 1917572 Maybridge4_000626 CCOc1ccc2[nH]c(SCc3c(F)c(F)c(F)c(F)c3F)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M11 compound treatment 1.94887977E8 -400000.0 -0.01 1.44178309E8 -5.16E7 -0.88 -0.6286 -0.7111 1003070 Maybridge4_000627 Cc1ccc(cc1)S(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M12 compound treatment 2.20531818E8 2.52E7 0.32 1.58497094E8 -3.73E7 -0.64 -0.2278 -0.3195 3062717 Maybridge4_000628 CSc1nc2c(=S)[nH]c(=S)[nH]c2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M13 compound treatment 2.01391521E8 6100000.0 0.08 1.53774979E8 -4.2E7 -0.72 -0.4547 -0.6283 3062718 Maybridge4_000629 O/N=C(/C(=N/O)/c1ccccc1)\c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M14 compound treatment 2.14964386E8 1.97E7 0.25 1.23197773E8 -7.26E7 -1.24 -0.7044 -0.5558 1781230 Maybridge4_000630 CCOC(=O)CNc1n[nH]c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M15 compound treatment 1.94067291E8 -1220000.0 -0.02 1.5814274E8 -3.77E7 -0.64 -0.4668 -0.7237 3062719 Maybridge4_000631 Cc1cc(C)nc(S/C=C/C(=O)c2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M16 compound treatment 1.61807631E8 -3.35E7 -0.42 1.6090079E8 -3.49E7 -0.6 -0.7196 -0.9851 1718236 Maybridge4_000632 Cn1c(=O)cc(N2CCOCC2)c3c(=O)n(c4ccccc4)c(=O)n(c5ccccc5)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M17 compound treatment 1.85840172E8 -9450000.0 -0.12 1.50011342E8 -4.58E7 -0.78 -0.6382 -0.8049 3178825 Maybridge4_000633 CC(=O)NC1=NN(C(N1C(=O)C)c2cccc3ccccc23)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M18 compound treatment 1.92575832E8 -2710000.0 -0.03 1.54101642E8 -4.17E7 -0.71 -0.529 -0.74 1286292 Maybridge4_000634 O=C(NC(C(=O)c1ccccc1)n2cnccc2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M19 compound treatment 1.73044415E8 -2.22E7 -0.28 1.54088672E8 -4.17E7 -0.71 -0.7024 -0.9159 1171458 Maybridge4_000635 OC(COCc1ccccc1)Cn2c3ccccc3c4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M20 compound treatment 1.41180507E8 -5.41E7 -0.68 1.33618002E8 -6.22E7 -1.06 -1.2328 -0.9764 3062720 Maybridge4_000636 C/S(=N\S(=O)(=O)c1ccc(C)cc1)/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M21 compound treatment 1.52264531E8 -4.3E7 -0.54 1.36542296E8 -5.93E7 -1.01 -1.0991 -0.9564 1311339 Maybridge4_000637 O=C(C(C#N)c1nc2ccccc2[nH]1)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M22 compound treatment 1.7828952E8 -1.7E7 -0.21 1.77381605E8 -1.84E7 -0.32 -0.3739 -0.9818 1645478 Maybridge4_000638 COC(=O)C1C([C@H]2c3ccccc3[C@@H]1c4ccccc24)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M23 mock treatment 1.73721384E8 -2.16E7 -0.27 1.53705757E8 -4.21E7 -0.72 -0.701 -0.9105 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 M24 mock treatment 1.6885284E8 -2.64E7 -0.33 1.55037127E8 -4.08E7 -0.7 -0.7281 -0.9421 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N01 compound treatment 1.53301053E8 -4.2E7 -0.53 1.53035591E8 -4.28E7 -0.73 -0.8902 -0.9869 1273203 Maybridge4_000639 CN(C)CC1(CC(=O)O)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N02 compound treatment 1.654862E8 -2.98E7 -0.37 1.54632344E8 -4.12E7 -0.7 -0.7628 -0.956 3178826 Maybridge4_000640 NN/C(=N/S(=O)(=O)c1ccccc1)/N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N03 compound treatment 1.51677113E8 -4.36E7 -0.55 1.61420731E8 -3.44E7 -0.59 -0.8031 -0.9993 3062722 Maybridge4_000641 O=C1NC(=O)C(=C/C=C/c2ccccc2)C(=O)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N04 compound treatment 1.61277189E8 -3.4E7 -0.43 1.49975255E8 -4.58E7 -0.78 -0.8565 -0.959 1678177 Maybridge4_000642 COc1cccc(OC)c1C(=O)Nc2ccccc2NC(=O)c3c(OC)cccc3OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N05 compound treatment 8.459868E7 -1.11E8 -1.39 1.66160202E8 -2.97E7 -0.51 -1.3408 -0.9069 1073885 Maybridge4_000643 CCOc1ccc(CCC(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N06 compound treatment 1.74011775E8 -2.13E7 -0.27 1.56319707E8 -3.95E7 -0.68 -0.6668 -0.9174 3178827 Maybridge4_000644 CS/C(=N\S(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)/N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N07 compound treatment 9.768602E7 -9.76E7 -1.22 1.54279864E8 -4.15E7 -0.71 -1.3685 -0.9666 3062723 Maybridge4_000645 Oc1noc(O)c1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N08 compound treatment 1.81527895E8 -1.38E7 -0.17 1.52224544E8 -4.36E7 -0.75 -0.6497 -0.8483 3062724 Maybridge4_000646 NC(=S)NC1CC2CC1C=C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N09 compound treatment 1.62179725E8 -3.31E7 -0.42 1.53882506E8 -4.19E7 -0.72 -0.8012 -0.9662 3178828 Maybridge4_000647 CCNc1cc(N)[n+](CC)c2[nH]nc(N)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N10 compound treatment 1.32327526E8 -6.3E7 -0.79 1.27530185E8 -6.83E7 -1.17 -1.385 -0.9818 1512370 Maybridge4_000648 COc1ccc(cc1CN2CCOCC2)c3cc(c4ccccc4)c(nn3)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N11 compound treatment 1.57463065E8 -3.78E7 -0.47 9.4793226E7 -1.01E8 -1.73 -1.5583 -0.869 1288584 Maybridge4_000649 S=C(NC1CC2CC1C=C2)N(CCC#N)Cc3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N12 compound treatment 1.4671909E8 -4.86E7 -0.61 1.4196213E8 -5.39E7 -0.92 -1.0827 -0.9798 3178829 Maybridge4_000650 CC(=O)NCc1c(F)cccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N13 compound treatment 1.61061318E8 -3.42E7 -0.43 1.45766589E8 -5.0E7 -0.86 -0.9094 -0.949 1566685 Maybridge4_000651 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2cccc(SC)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N14 compound treatment 1.91824194E8 -3460000.0 -0.04 1.57706398E8 -3.81E7 -0.65 -0.492 -0.7525 3062725 Maybridge4_000652 Fc1cccc(Cl)c1CSc2ccccc2C3=NCCCN3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N15 compound treatment 1.59977223E8 -3.53E7 -0.44 1.48993217E8 -4.68E7 -0.8 -0.8799 -0.9609 3178830 Maybridge4_000653 Cc1c(C)c(C)c(CSC2=NCCS2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N16 compound treatment 1.69099323E8 -2.62E7 -0.33 1.62211664E8 -3.36E7 -0.58 -0.639 -0.9647 3062726 Maybridge4_000654 Clc1cc(C[n+]2ccccc2)c3OCOCc3c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N17 compound treatment 1.61668299E8 -3.36E7 -0.42 1.63189309E8 -3.26E7 -0.56 -0.6931 -0.9904 3062727 Maybridge4_000655 Cn1c(S)nnc1CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N18 compound treatment 1.54340975E8 -4.09E7 -0.51 1.62794928E8 -3.3E7 -0.57 -0.7629 -0.9989 3178831 Maybridge4_000656 CC1CC(C)CN(C1)S(=O)(=O)c2c(C)c(C)c(C)c(C)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N19 compound treatment 1.40325289E8 -5.5E7 -0.69 1.41380196E8 -5.44E7 -0.93 -1.1464 -0.989 3178832 Maybridge4_000657 N#Cc1cccc(CSc2nnc(SCc3cccc(C#N)c3)s2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N20 compound treatment 1.65377213E8 -2.99E7 -0.38 1.53965718E8 -4.18E7 -0.72 -0.7719 -0.9545 3062728 Maybridge4_000658 CC1(C)ON(C(=N1)NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N21 compound treatment 1.47704096E8 -4.76E7 -0.6 1.56996792E8 -3.88E7 -0.66 -0.8919 -0.9986 3178833 Maybridge4_000659 CC1N=C(SCC#N)N2C(C)N=C(SCC#N)N12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N22 compound treatment 1.51733655E8 -4.36E7 -0.55 1.443618E8 -5.15E7 -0.88 -1.0091 -0.9736 1490971 Maybridge4_000660 Nc1ccccc1C(=O)NCc2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N23 mock treatment 1.58036393E8 -3.73E7 -0.47 1.4769944E8 -4.81E7 -0.82 -0.9128 -0.964 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 N24 mock treatment 1.64763117E8 -3.05E7 -0.38 1.54916944E8 -4.09E7 -0.7 -0.7658 -0.9597 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O01 compound treatment 8.7397036E7 -1.08E8 -1.35 1.16256315E8 -7.96E7 -1.36 -1.92 -1.0 3178834 Maybridge4_000661 COc1ccccc1C2OC(=O)C[C@H]2C(=O)Oc3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O02 compound treatment 1.1236364E8 -8.29E7 -1.04 1.34528681E8 -6.13E7 -1.05 -1.4774 -1.0 3178835 Maybridge4_000662 FC(F)(F)c1cc(NC(=S)NCCN2CCNC2=O)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O03 compound treatment 1.01787519E8 -9.35E7 -1.17 1.06575016E8 -8.92E7 -1.53 -1.9095 -0.9915 1251917 Maybridge4_000663 Cc1ccc(OC(C)(C)C(=O)Nc2ccc(Oc3ccc(F)cc3F)nc2)c4CCCc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O04 compound treatment 1.36677742E8 -5.86E7 -0.74 1.68373097E8 -2.74E7 -0.47 -0.852 -0.9766 3178836 Maybridge4_000664 Cc1ccccc1NC2=NCC(C)(C)S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O05 compound treatment 1.68393536E8 -2.69E7 -0.34 1.84021923E8 -1.18E7 -0.2 -0.3813 -0.9698 1342095 Maybridge4_000665 NC(=O)C1c2ccccc2Oc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O06 compound treatment 1.53565585E8 -4.17E7 -0.52 1.62152984E8 -3.37E7 -0.58 -0.7775 -0.9988 3178916 Maybridge4_000666 CC(C)(C)NC(=O)Oc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O07 compound treatment 1.61231981E8 -3.41E7 -0.43 1.67518586E8 -2.83E7 -0.48 -0.6446 -0.998 1101019 Maybridge4_000667 CC(C)(C)c1cc(c2oc(cc(=O)c2c1)C(=O)O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O08 compound treatment 1.66742573E8 -2.85E7 -0.36 1.84713998E8 -1.11E7 -0.19 -0.3876 -0.9561 1485865 Maybridge4_000668 Clc1ccc(OC2CN(C2)C(=O)NCC=C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O09 compound treatment 1.67301675E8 -2.8E7 -0.35 1.77946749E8 -1.79E7 -0.31 -0.4645 -0.9976 3178917 Maybridge4_000669 O=C(Oc1ccc2ccccc2c1)C3c4ccccc4Oc5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O10 compound treatment 1.54867988E8 -4.04E7 -0.51 1.75817331E8 -2.0E7 -0.34 -0.6006 -0.9817 1074403 Maybridge4_000670 C1CCC(CC1)Nc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O11 compound treatment 1.66771369E8 -2.85E7 -0.36 1.82361029E8 -1.35E7 -0.23 -0.4158 -0.9773 1171317 Maybridge4_000671 COc1cc(OC)cc(c1)C(C)(C)OC(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O12 compound treatment 1.88682474E8 -6610000.0 -0.08 1.86010273E8 -9800000.0 -0.17 -0.1773 -0.9471 1302360 Maybridge4_000672 OC(=O)Cc1cncc(Br)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O13 compound treatment 1.42951682E8 -5.23E7 -0.66 1.66051463E8 -2.98E7 -0.51 -0.8245 -0.9921 3063089 Maybridge4_000673 C/C(=N\O)/c1c(O)c2ccccc2n(C)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O14 compound treatment 1.59130732E8 -3.62E7 -0.45 1.63464584E8 -3.23E7 -0.55 -0.7123 -0.9951 1915396 Maybridge4_000674 CC1(C)OC2C(CO)OC(C2O1)n3cnc4c(=O)[nH]cnc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O15 compound treatment 1.86891204E8 -8400000.0 -0.11 2.00666918E8 4850000.0 0.08 -0.0157 -0.1174 1665055 Maybridge4_000675 CC(=O)OCc1ccccc1Sc2ccccc2C(=O)NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O16 compound treatment 1.73380174E8 -2.19E7 -0.27 1.65236987E8 -3.06E7 -0.52 -0.5644 -0.9548 3063091 Maybridge4_000676 CN1C(=O)/C(=C\NCc2ccccc2)/C(=O)c3c1n(C)c(=O)n(C)c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O17 compound treatment 1.54815442E8 -4.05E7 -0.51 1.58490938E8 -3.73E7 -0.64 -0.8108 -0.9935 3178918 Maybridge4_000677 COC(=O)c1cc(=O)nc2O[C@@H]3C(O)[C@@H](CO)OC3n21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O18 compound treatment 1.92546151E8 -2740000.0 -0.03 1.86412387E8 -9400000.0 -0.16 -0.1381 -0.8393 1458724 Maybridge4_000678 OC(=O)CCC1(CC2CC3CC(O)(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O19 compound treatment 1.71141045E8 -2.41E7 -0.3 1.78319471E8 -1.75E7 -0.3 -0.426 -1.0 3178919 Maybridge4_000679 CCn1c2ccc(Cl)cc2c3cc(Cl)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O20 compound treatment 1.91049888E8 -4240000.0 -0.05 1.99628475E8 3810000.0 0.07 0.0086 0.1018 1547077 Maybridge4_000680 Cc1ccc(cc1)S(=O)(=O)N=S(Cc2ccccc2)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O21 compound treatment 1.84750002E8 -1.05E7 -0.13 2.01988968E8 6170000.0 0.11 -0.0187 -0.1107 3063093 Maybridge4_000681 CC(C)(C)c1ccc(=O)[nH]n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O22 compound treatment 1.86096758E8 -9190000.0 -0.12 1.79412961E8 -1.64E7 -0.28 -0.2801 -0.9227 3178920 Maybridge4_000682 Brc1ccc(NC(=O)N2NC(=O)[C@H]([C@@H]2c3ccccc3)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O23 mock treatment 1.75531834E8 -1.98E7 -0.25 1.97704157E8 1890000.0 0.03 -0.1524 -0.6096 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 O24 mock treatment 1.90644409E8 -4640000.0 -0.06 1.87018545E8 -8800000.0 -0.15 -0.1477 -0.9146 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P01 compound treatment 2.08848486E8 1.36E7 0.17 2.16668797E8 2.09E7 0.36 0.3727 0.9425 3063094 Maybridge4_000683 COC(=O)/C=C/c1cn(C2OCC(CO)C2O)c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P02 compound treatment 2.00011401E8 4720000.0 0.06 1.99023108E8 3210000.0 0.05 0.0807 0.9993 3178921 Maybridge4_000684 NNC(=O)CS(=O)Cc1cccc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P03 compound treatment 2.15328785E8 2.0E7 0.25 2.11830707E8 1.6E7 0.27 0.3716 0.9991 3063095 Maybridge4_000685 O=C1NC(=O)C(=Cc2cccc3ccccc23)C(=O)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P04 compound treatment 2.09228609E8 1.39E7 0.17 2.3078464E8 3.5E7 0.6 0.5469 0.877 3178922 Maybridge4_000686 O/N=C/c1ccc(o1)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P05 compound treatment 2.11886394E8 1.66E7 0.21 2.06127604E8 1.03E7 0.18 0.2721 0.9966 1352669 Maybridge4_000687 COc1cccc(NC(=S)NC(Cc2ccccc2)c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P06 compound treatment 1.81914939E8 -1.34E7 -0.17 1.94718491E8 -1100000.0 -0.02 -0.1319 -0.7813 1145524 Maybridge4_000688 Clc1ccc(Cl)c(NC(=S)Nc2ccc(nc2)N3CCOCC3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P07 compound treatment 1.93350238E8 -1940000.0 -0.02 2.11424861E8 1.56E7 0.27 0.1718 0.6401 1152510 Maybridge4_000689 COc1ccc(CSC2=C(C#N)C(=O)NC3(CCCCC3)S2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P08 compound treatment 1.64773866E8 -3.05E7 -0.38 1.87726908E8 -8090000.0 -0.14 -0.3686 -0.9054 3063149 Maybridge4_000690 Clc1ccccc1NC(=O)CC2SC(=NC2=O)NC3CC4CC3C=C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P09 compound treatment 1.94209695E8 -1080000.0 -0.01 1.94531183E8 -1280000.0 -0.02 -0.0251 -0.9729 3178923 Maybridge4_000691 CCNc1cc(N)[n+](CC)c2[nH]nc(/N=C/c3cc(Cl)cc(Cl)c3O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P10 compound treatment 1.89310918E8 -5980000.0 -0.07 2.22078667E8 2.63E7 0.45 0.2649 0.5812 3063150 Maybridge4_000692 N/C(=N\O)/CN1CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P11 compound treatment 1.99091664E8 3800000.0 0.05 1.99341948E8 3530000.0 0.06 0.0764 0.9932 1138088 Maybridge4_000693 S=C(NC1CC2CC1C=C2)N(CCC#N)CC3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P12 compound treatment 1.77446233E8 -1.78E7 -0.22 1.8147999E8 -1.43E7 -0.25 -0.3318 -0.9989 3063152 Maybridge4_000694 Fc1cccc(Cl)c1CSC2=NCCN2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P13 compound treatment 1.87829621E8 -7460000.0 -0.09 1.99795912E8 3980000.0 0.07 -0.018 -0.1552 1637772 Maybridge4_000695 Cc1onc(c1C(=O)N2CCCN3C2c4ccccc4C3=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P14 compound treatment 1.96074144E8 786000.0 0.01 2.09169786E8 1.34E7 0.23 0.1686 0.7369 3063153 Maybridge4_000696 Nn1c(nc2ccccc2c1=O)C(=O)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P15 compound treatment 1.32807506E8 -6.25E7 -0.78 1.30404308E8 -6.54E7 -1.12 -1.346 -0.9848 1322891 Maybridge4_000697 CCOC(=O)CCc1ccc(OCc2c(C)c(C)c(C)c(C)c2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P16 compound treatment 1.47704509E8 -4.76E7 -0.6 1.42881691E8 -5.29E7 -0.91 -1.0628 -0.9795 3063154 Maybridge4_000698 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NCCCN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P17 compound treatment 1.9868924E8 3400000.0 0.04 2.02726487E8 6910000.0 0.12 0.1138 0.905 1180785 Maybridge4_000699 Cc1c(C)c(C)c(C(=O)CCc2cccc(NC(=O)C3CCC3)c2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P18 compound treatment 1.95885362E8 597000.0 0.01 2.01512912E8 5700000.0 0.1 0.0743 0.7592 3063155 Maybridge4_000700 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NC(=N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P19 compound treatment 1.94785524E8 -502000.0 -0.01 2.03103933E8 7290000.0 0.12 0.0838 0.6705 3178924 Maybridge4_000701 N/C(=N\O)/Cc1nc(cs1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P20 compound treatment 2.11127851E8 1.58E7 0.2 2.04466406E8 8650000.0 0.15 0.2452 0.9895 3063157 Maybridge4_000702 Cc1nnsc1C(=O)NC(=O)Nc2cc(Cl)cc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P21 compound treatment 1.74324171E8 -2.1E7 -0.26 1.76968606E8 -1.88E7 -0.32 -0.4141 -0.9949 3178925 Maybridge4_000703 CC1(C)NN(C(=N1)S)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P22 compound treatment 1.85761506E8 -9530000.0 -0.12 1.81044119E8 -1.48E7 -0.25 -0.2633 -0.9415 3063158 Maybridge4_000704 CSc1nc(nc(SC)c1Cl)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P23 mock treatment 1.81480375E8 -1.38E7 -0.17 1.91976865E8 -3840000.0 -0.07 -0.1689 -0.9119 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2050 P24 mock treatment 1.84498319E8 -1.08E7 -0.14 1.83088522E8 -1.27E7 -0.22 -0.2497 -0.9738 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A01 compound treatment 1.3659593E8 -3.27E7 -0.41 1.18697615E8 -3.23E7 -0.55 -0.6804 -0.9892 1580862 Maybridge4_000705 CC1CC(C)CN(C1)c2ccc(NC(=O)c3ccc(Cl)cc3)cc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A02 compound treatment 1.41090052E8 -2.82E7 -0.35 1.17662431E8 -3.33E7 -0.57 -0.6531 -0.9736 3063159 Maybridge4_000706 Cc1nn(C)c(Cl)c1S(=O)(=O)Nc2ccc(C)cc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A03 compound treatment 1.4799725E8 -2.13E7 -0.27 1.26939316E8 -2.4E7 -0.41 -0.4795 -0.9781 3178926 Maybridge4_000707 CN(C)/C=N/S(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A04 compound treatment 1.48642882E8 -2.06E7 -0.26 1.24482104E8 -2.65E7 -0.45 -0.5035 -0.9646 3178927 Maybridge4_000708 Clc1ccc(NC(=S)N2CCCC2c3cccs3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A05 compound treatment 1.32277363E8 -3.7E7 -0.46 1.16417762E8 -3.45E7 -0.59 -0.7463 -0.9928 3063160 Maybridge4_000709 Cn1nccc1c2cc(F)cc(F)c2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A06 compound treatment 1.48633349E8 -2.06E7 -0.26 1.20477001E8 -3.05E7 -0.52 -0.5521 -0.9477 3178928 Maybridge4_000710 O=C(NC(=O)c1ccc(cc1)S(=O)(=O)N2CCOCC2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A07 compound treatment 1.47937591E8 -2.13E7 -0.27 1.29817787E8 -2.11E7 -0.36 -0.4452 -0.9889 3063161 Maybridge4_000711 Fc1cccc(Cl)c1COC(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A08 compound treatment 1.37594574E8 -3.17E7 -0.4 1.17870216E8 -3.31E7 -0.57 -0.6815 -0.9849 3063162 Maybridge4_000712 CN(C)/C=C/C(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A09 compound treatment 1.18840397E8 -5.04E7 -0.63 1.11916133E8 -3.9E7 -0.67 -0.92 -0.9996 1674451 Maybridge4_000713 CN(NS(=O)(=O)c1cc(C)c(F)c(C)c1)c2cccc(Cl)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A10 compound treatment 1.21935499E8 -4.73E7 -0.59 1.25706589E8 -2.53E7 -0.43 -0.7256 -0.9879 3063163 Maybridge4_000714 CN(C)/C=C/1\SCc2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A11 compound treatment 1.49372956E8 -1.99E7 -0.25 1.30326346E8 -2.06E7 -0.35 -0.4263 -0.9855 3178929 Maybridge4_000715 Cc1onc(c1C(=O)c2ccc(F)cc2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A12 compound treatment 1.59192352E8 -1.01E7 -0.13 1.38239605E8 -1.27E7 -0.22 -0.2434 -0.9665 1518860 Maybridge4_000716 COc1cccc(OC)c1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A13 compound treatment 1.49892084E8 -1.94E7 -0.24 1.33258539E8 -1.77E7 -0.3 -0.3862 -0.994 1454624 Maybridge4_000717 CC1=C(O)C(=O)OC1c2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A14 compound treatment 1.47971707E8 -2.13E7 -0.27 1.39773691E8 -1.12E7 -0.19 -0.3244 -0.9867 3178930 Maybridge4_000718 Cc1nc(COc2cc(C)c(Cl)c(C)c2Cl)cs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A15 compound treatment 1.09807756E8 -5.95E7 -0.75 1.01068714E8 -4.99E7 -0.85 -1.1314 -0.9977 3178931 Maybridge4_000719 Clc1ccc(NC(=O)C(C#N)C(=O)c2cccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A16 compound treatment 1.67076921E8 -2190000.0 -0.03 1.41193997E8 -9770000.0 -0.17 -0.1377 -0.8125 1203853 Maybridge4_000720 CC1N(CCc2sccc12)C(=S)NC(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A17 compound treatment 1.50820914E8 -1.84E7 -0.23 1.34471732E8 -1.65E7 -0.28 -0.3633 -0.9951 3178932 Maybridge4_000721 CSc1nc(NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)nn1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A18 compound treatment 1.28642079E8 -4.06E7 -0.51 1.18611198E8 -3.24E7 -0.55 -0.752 -0.9991 3063213 Maybridge4_000722 FC(F)(F)c1cccc(NC(=S)C(C#N)C(=O)N2CCCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A19 compound treatment 1.56750796E8 -1.25E7 -0.16 1.38881288E8 -1.21E7 -0.21 -0.2573 -0.9908 3178933 Maybridge4_000723 Cc1nn(C)c(C)c1NC(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A20 compound treatment 1.22827347E8 -4.64E7 -0.58 7.060579E7 -8.04E7 -1.38 -1.3846 -0.9269 1654657 Maybridge4_000724 Brc1ccc(Nc2ncnc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A21 compound treatment 1.48246035E8 -2.1E7 -0.26 1.43327019E8 -7640000.0 -0.13 -0.2789 -0.9476 1162031 Maybridge4_000725 Nc1n[nH]c(NC2CCCCNC2=O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A22 compound treatment 1.59598429E8 -9670000.0 -0.12 1.43491865E8 -7470000.0 -0.13 -0.1762 -0.9996 3179020 Maybridge4_000726 C1CCN2C(=CSC2=NC1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A23 mock treatment 1.43698051E8 -2.56E7 -0.32 1.41365431E8 -9600000.0 -0.16 -0.343 -0.9517 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 A24 mock treatment 1.60858889E8 -8410000.0 -0.11 1.43209279E8 -7760000.0 -0.13 -0.1685 -0.9935 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B01 compound treatment 1.35577354E8 -3.37E7 -0.42 1.39565316E8 -1.14E7 -0.2 -0.4368 -0.9384 1499601 Maybridge4_000727 S=C(Nc1ccccc1)Nc2ccccc2c3nc4ccccc4[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B02 compound treatment 1.32329601E8 -3.69E7 -0.46 9.1929205E7 -5.9E7 -1.01 -1.0422 -0.9375 1693956 Maybridge4_000728 CSc1cc(nc(c1)c2ccc(Cl)cc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B03 compound treatment 9.2714755E7 -7.66E7 -0.96 1.23931325E8 -2.7E7 -0.46 -1.0063 -0.944 3063216 Maybridge4_000729 CN1CNC(=NC1)SCc2ccc(C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B04 compound treatment 1.45087477E8 -2.42E7 -0.3 1.3578067E8 -1.52E7 -0.26 -0.3983 -0.997 3179021 Maybridge4_000730 FC(F)(F)c1ccccc1NC(=O)N/C=C/c2ccsc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B05 compound treatment 8.324333E7 -8.6E7 -1.08 1.05242988E8 -4.57E7 -0.78 -1.3165 -0.9876 1138498 Maybridge4_000731 CN(C)c1ccc(cc1)C2Nc3cc(C)ccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B06 compound treatment 1.36227935E8 -3.3E7 -0.41 1.26373731E8 -2.46E7 -0.42 -0.5907 -1.0 3179022 Maybridge4_000732 CC1=CC(=O)N(C1=O)c2ccn(C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B07 compound treatment 1.4164001E8 -2.76E7 -0.35 1.16690724E8 -3.43E7 -0.59 -0.6599 -0.9685 3179023 Maybridge4_000733 OC(=O)C1C(C2CC1C=C2)C(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B08 compound treatment 1.31179801E8 -3.81E7 -0.48 1.24693494E8 -2.63E7 -0.45 -0.6559 -0.9995 3063218 Maybridge4_000734 CCCc1c(cnn1c2ccccc2)c3nc(no3)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B09 compound treatment 1.58312655E8 -1.1E7 -0.14 1.39858324E8 -1.11E7 -0.19 -0.2316 -0.9873 3179024 Maybridge4_000735 FC(F)(F)c1cccc(NC2(CCCCCC2)C#N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B10 compound treatment 1.41305298E8 -2.8E7 -0.35 1.12078364E8 -3.89E7 -0.67 -0.7187 -0.9552 1512806 Maybridge4_000736 Cc1csc2c(ncnc12)N3CCSCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B11 compound treatment 1.41244489E8 -2.8E7 -0.35 1.23095347E8 -2.79E7 -0.48 -0.5859 -0.9887 1281080 Maybridge4_000737 CS(=O)(=O)N1CCCN2C1c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B12 compound treatment 1.46064667E8 -2.32E7 -0.29 1.23723775E8 -2.72E7 -0.47 -0.5356 -0.9743 3179025 Maybridge4_000738 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2noc(n2)C3CCc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B13 compound treatment 1.27371085E8 -4.19E7 -0.53 1.06149232E8 -4.48E7 -0.77 -0.9141 -0.983 3063220 Maybridge4_000739 Cc1c(C)c(C)c(CSCc2n[nH]c(=S)n2c3ccc(F)cc3)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B14 compound treatment 1.17630189E8 -5.16E7 -0.65 1.0513482E8 -4.58E7 -0.78 -1.0128 -0.9955 3179026 Maybridge4_000740 Cc1csc2ncnc(Sc3ccccc3NS(=O)(=O)c4ccc(F)cc4)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B15 compound treatment 1.4388171E8 -2.54E7 -0.32 1.18666239E8 -3.23E7 -0.55 -0.6161 -0.9657 3063222 Maybridge4_000741 CS/C(=N\C(=O)c1c(Cl)cccc1Cl)/N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B16 compound treatment 1.20961993E8 -4.83E7 -0.61 9.7733656E7 -5.32E7 -0.91 -1.0728 -0.9804 1691561 Maybridge4_000742 Cc1csc2ncnc(N3CCN(CC3)C(=S)NCC4CC4)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B17 compound treatment 1.20459556E8 -4.88E7 -0.61 1.0572886E8 -4.52E7 -0.77 -0.9805 -0.9932 1442583 Maybridge4_000743 Cc1ccc(C(=S)N)c(O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B18 compound treatment 1.39747463E8 -2.95E7 -0.37 1.17640022E8 -3.33E7 -0.57 -0.6652 -0.9781 1597708 Maybridge4_000744 COc1cc2CCNC(=O)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B19 compound treatment 1.46846619E8 -2.24E7 -0.28 1.2246875E8 -2.85E7 -0.49 -0.5438 -0.9658 3179027 Maybridge4_000745 FC(F)(F)Oc1ccc(cc1)n2c(=N)c(/N=C/c3ccc(cc3)C(F)(F)F)c(C#N)[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B20 compound treatment 1.07707792E8 -6.16E7 -0.77 8.3265395E7 -6.77E7 -1.16 -1.3655 -0.9805 1614161 Maybridge4_000746 Cc1csc(NC(=O)NS(=O)(=O)c2ccc(C)cc2)c1C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B21 compound treatment 1.44639697E8 -2.46E7 -0.31 1.0756786E8 -4.34E7 -0.74 -0.7438 -0.9244 3179028 Maybridge4_000747 Cc1csc(NC(=O)CSc2ccc(Cl)cc2)c1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B22 compound treatment 1.38065521E8 -3.12E7 -0.39 1.09486925E8 -4.15E7 -0.71 -0.7788 -0.9606 3063278 Maybridge4_000748 NNC(=S)Nc1ccccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B23 mock treatment 1.36672961E8 -3.26E7 -0.41 9.3550252E7 -5.74E7 -0.98 -0.9841 -0.9245 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 B24 mock treatment 1.29702747E8 -3.96E7 -0.5 1.04193248E8 -4.68E7 -0.8 -0.9171 -0.9736 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C01 compound treatment 1.18283361E8 -5.1E7 -0.64 1.14271106E8 -3.67E7 -0.63 -0.8964 -1.0 3179029 Maybridge4_000749 Cc1cc(C)n(Cc2c(Cl)cccc2Cl)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C02 compound treatment 1.19224899E8 -5.0E7 -0.63 1.11599575E8 -3.94E7 -0.67 -0.9204 -0.9994 3063279 Maybridge4_000750 CC1SCC(CS1)NC(=O)c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C03 compound treatment 1.24556053E8 -4.47E7 -0.56 1.15148475E8 -3.58E7 -0.61 -0.8302 -0.999 3179030 Maybridge4_000751 CC(C)(C)n1cnnc1S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C04 compound treatment 1.18844275E8 -5.04E7 -0.63 1.14053712E8 -3.69E7 -0.63 -0.8941 -1.0 3179031 Maybridge4_000752 Cc1c(cnn1c2ccc(Cl)cc2)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C05 compound treatment 9.0253171E7 -7.9E7 -0.99 8.8140672E7 -6.28E7 -1.08 -1.4613 -0.9992 3063283 Maybridge4_000753 CN(C)/C=c/1\s\c(=C\C(=O)c2cccs2)\[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C06 compound treatment 1.26350165E8 -4.29E7 -0.54 1.15056134E8 -3.59E7 -0.61 -0.8154 -0.9978 3179032 Maybridge4_000754 Fc1ccc(c2ccc(o2)c3ccnn3S(=O)(=O)c4ccc(F)cc4F)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C07 compound treatment 1.15507948E8 -5.38E7 -0.67 1.08366479E8 -4.26E7 -0.73 -0.9925 -0.9992 3063284 Maybridge4_000755 FC(F)(F)c1cc(cc(c1)S(=O)(=O)NC(=N)N2CCSCC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C08 compound treatment 1.14522252E8 -5.47E7 -0.69 1.09064882E8 -4.19E7 -0.72 -0.9928 -0.9998 3179033 Maybridge4_000756 NC(=O)N/C(=N/O)/CSCc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C09 compound treatment 1.22940122E8 -4.63E7 -0.58 1.13291713E8 -3.77E7 -0.64 -0.867 -0.9987 3063285 Maybridge4_000757 Fc1cc(CSc2ccc(Cl)cc2)c3OCOCc3c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C10 compound treatment 1.24110059E8 -4.52E7 -0.57 1.07695387E8 -4.33E7 -0.74 -0.9243 -0.9912 1433051 Maybridge4_000758 CCOC(=O)Cc1nc(N)ncc1C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C11 compound treatment 1.11821732E8 -5.74E7 -0.72 1.08367413E8 -4.26E7 -0.73 -1.0252 -1.0 1461982 Maybridge4_000759 Cc1onc(c1C(O)c2ccc(F)cc2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C12 compound treatment 1.10121421E8 -5.91E7 -0.74 1.0585908E8 -4.51E7 -0.77 -1.0706 -0.9998 1346508 Maybridge4_000760 COc1ccc2C(NN(C)c3cccc(F)c3C#N)OC(=O)c2c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C13 compound treatment 1.29011777E8 -4.03E7 -0.51 1.17722621E8 -3.32E7 -0.57 -0.7595 -0.9982 3179034 Maybridge4_000761 CN(C)/C=N/C(=S)NC1CC2CC1C=C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C14 compound treatment 1.12576357E8 -5.67E7 -0.71 1.08452113E8 -4.25E7 -0.73 -1.0175 -0.9999 1675569 Maybridge4_000762 C(N1CC(CN(Cc2ccccc2)C1)c3nn[nH]n3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C15 compound treatment 1.35235475E8 -3.4E7 -0.43 1.23176998E8 -2.78E7 -0.48 -0.6382 -0.9985 3063288 Maybridge4_000763 CNC(=O)n1cc(c(C)n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C16 compound treatment 1.37829823E8 -3.14E7 -0.39 1.32526066E8 -1.84E7 -0.32 -0.5021 -0.9939 1260907 Maybridge4_000764 CC1N(CCc2sccc12)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C17 compound treatment 1.31149098E8 -3.81E7 -0.48 1.2168928E8 -2.93E7 -0.5 -0.6925 -0.9997 1246781 Maybridge4_000765 CN(C)c1cccc(N(C)C)c1CNC(=O)c2ccccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C18 compound treatment 1.09171783E8 -6.01E7 -0.75 1.04938005E8 -4.6E7 -0.79 -1.0902 -0.9998 3179035 Maybridge4_000766 FC(F)(F)c1cccc(NC(=O)C(C#N)C(=S)Nc2ccccc2Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C19 compound treatment 1.41987468E8 -2.73E7 -0.34 1.30478871E8 -2.05E7 -0.35 -0.49 -0.9999 3063289 Maybridge4_000767 CNC(=O)N1CCCC(Cn2cccc2)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C20 compound treatment 1.44224482E8 -2.5E7 -0.31 1.26804142E8 -2.42E7 -0.41 -0.5146 -0.9908 1385501 Maybridge4_000768 Cc1ccc(cc1)c2csc(=N)n2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C21 compound treatment 1.35653851E8 -3.36E7 -0.42 1.28116517E8 -2.28E7 -0.39 -0.5747 -0.9993 1144063 Maybridge4_000769 Clc1ccc(NC(=O)NC2CCCCNC2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C22 compound treatment 1.38519044E8 -3.08E7 -0.39 1.33028146E8 -1.79E7 -0.31 -0.4899 -0.9936 3179036 Maybridge4_000770 CC1CN=C(N1)SCc2c(C)c(C)c(C)c(C)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C23 mock treatment 1.39710732E8 -2.96E7 -0.37 1.26788734E8 -2.42E7 -0.41 -0.5548 -0.9985 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 C24 mock treatment 1.42795788E8 -2.65E7 -0.33 1.29387715E8 -2.16E7 -0.37 -0.496 -0.9986 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D01 compound treatment 1.32507487E8 -3.68E7 -0.46 1.34859773E8 -1.61E7 -0.28 -0.521 -0.9697 3063290 Maybridge4_000771 CSC1=NCCN1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D02 compound treatment 1.2299757E8 -4.63E7 -0.58 1.17883295E8 -3.31E7 -0.57 -0.8109 -0.9999 3179037 Maybridge4_000772 COC(=O)c1sc(cc1NC(=O)Nc2ccc(Cl)cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D03 compound treatment 1.30146623E8 -3.91E7 -0.49 1.2767526E8 -2.33E7 -0.4 -0.6289 -0.9947 3063291 Maybridge4_000773 Cc1ccc(Cc2nc(cs2)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D04 compound treatment 1.21415841E8 -4.79E7 -0.6 1.16738732E8 -3.42E7 -0.59 -0.8388 -0.9999 3179038 Maybridge4_000774 FC(F)(F)c1cc(SC(=O)N/C=C/c2ccsc2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D05 compound treatment 1.24285751E8 -4.5E7 -0.56 1.15172078E8 -3.58E7 -0.61 -0.8323 -0.9992 1247834 Maybridge4_000775 CC(C)(C)CC(C)(C)N1CNC(=S)NC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D06 compound treatment 1.19541116E8 -4.97E7 -0.62 1.14706378E8 -3.63E7 -0.62 -0.88 -1.0 3179039 Maybridge4_000776 Cn1cc(Br)c(n1)N2C(=O)C=CC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D07 compound treatment 9.9970653E7 -6.93E7 -0.87 1.00961906E8 -5.0E7 -0.86 -1.2199 -1.0 3179040 Maybridge4_000777 COc1cc(cc(OC)c1OC)C(O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D08 compound treatment 1.14082203E8 -5.52E7 -0.69 1.11051571E8 -3.99E7 -0.68 -0.9726 -1.0 3063293 Maybridge4_000778 CCCc1nn(cc1C(=O)Nc2ccc(Cl)cc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D09 compound treatment 1.06892277E8 -6.24E7 -0.78 1.05820896E8 -4.51E7 -0.77 -1.0997 -1.0 1432923 Maybridge4_000779 CC(NC(=O)c1c(C)onc1c2ccccc2Cl)c3ccc(C)cc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D10 compound treatment 1.17315168E8 -5.2E7 -0.65 1.08135825E8 -4.28E7 -0.73 -0.9793 -0.9983 3179041 Maybridge4_000780 FC(F)(F)c1c(cnn1c2ccc(Cl)cc2)C(=O)NCCc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D11 compound treatment 8.1649035E7 -8.76E7 -1.1 7.5223733E7 -7.57E7 -1.3 -1.694 -0.9966 3179119 Maybridge4_000781 COc1cc(cc(OC)c1OC)C(=O)N2/C(=N/c3ccccc3Cl)/SC(=C)C2(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D12 compound treatment 1.22271268E8 -4.7E7 -0.59 1.17252244E8 -3.37E7 -0.58 -0.825 -0.9999 3062512 Maybridge4_000782 COC(=O)c1cnc(NN2C(=O)C=C(C)C2=O)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D13 compound treatment 1.31701386E8 -3.76E7 -0.47 1.19218027E8 -3.17E7 -0.54 -0.7175 -0.9975 1164825 Maybridge4_000783 NNC(=O)Oc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D14 compound treatment 1.0920776E8 -6.01E7 -0.75 1.11259627E8 -3.97E7 -0.68 -1.0134 -0.9987 3179120 Maybridge4_000784 COC(=O)c1sccc1Oc2ccc(cc2NC(=O)/C=C/C(=O)O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D15 compound treatment 1.15027094E8 -5.42E7 -0.68 1.19076527E8 -3.19E7 -0.55 -0.8671 -0.994 3062514 Maybridge4_000785 Clc1cccc(Cl)c1C(=O)N=C2NCCCN2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D16 compound treatment 1.23310227E8 -4.6E7 -0.58 1.17556434E8 -3.34E7 -0.57 -0.8121 -1.0 3179121 Maybridge4_000786 FC(F)(F)c1cccc(c1)S(=O)(=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D17 compound treatment 1.05386942E8 -6.39E7 -0.8 1.01301675E8 -4.97E7 -0.85 -1.1678 -0.9996 3062515 Maybridge4_000787 CCOC(=O)C1=C(C)NC(=NC1c2cccs2)SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D18 compound treatment 1.28286668E8 -4.1E7 -0.51 1.27077373E8 -2.39E7 -0.41 -0.6527 -0.9936 3179122 Maybridge4_000788 CCOC(=O)c1cnc(SCc2c(C)cc(C)cc2C)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D19 compound treatment 1.24022177E8 -4.52E7 -0.57 1.18073489E8 -3.29E7 -0.56 -0.7995 -1.0 1515946 Maybridge4_000789 Fc1ccc(cc1)C(=O)ON(C2C3CC4CC(C3)CC2C4)C(=O)c5ccc(F)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D20 compound treatment 1.31591311E8 -3.77E7 -0.47 1.20836171E8 -3.01E7 -0.52 -0.6989 -0.9991 1700551 Maybridge4_000790 COC(=O)CNS(=O)(=O)c1ccsc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D21 compound treatment 1.13515625E8 -5.58E7 -0.7 1.05771059E8 -4.52E7 -0.77 -1.0416 -0.9987 1564868 Maybridge4_000791 Clc1cc(Cl)cc(c1)c2nnc(o2)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D22 compound treatment 9.9548035E7 -6.97E7 -0.87 9.0861724E7 -6.01E7 -1.03 -1.346 -0.9967 3179123 Maybridge4_000792 COc1cc2ncnc(NCCCn3ccnc3)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D23 mock treatment 8.0878082E7 -8.84E7 -1.11 8.7503311E7 -6.35E7 -1.09 -1.5522 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 D24 mock treatment 6.5174962E7 -1.04E8 -1.31 6.2220845E7 -8.87E7 -1.52 -1.9975 -0.9972 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E01 compound treatment 1.2017622E8 -4.91E7 -0.62 1.55766949E8 4800000.0 0.08 -0.3773 -0.6073 3062517 Maybridge4_000793 CCc1nc2ccccc2nc1CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E02 compound treatment 1.20577493E8 -4.87E7 -0.61 1.38208534E8 -1.28E7 -0.22 -0.5863 -0.9039 3179124 Maybridge4_000794 Cc1nc(S)c(C#N)c(C)c1Cc2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E03 compound treatment 1.21871913E8 -4.74E7 -0.59 1.55452629E8 4490000.0 0.08 -0.3661 -0.6107 3062519 Maybridge4_000795 Fc1cccc(CSCc2c(F)cccc2Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E04 compound treatment 1.13065675E8 -5.62E7 -0.71 1.40271845E8 -1.07E7 -0.18 -0.628 -0.8621 3179125 Maybridge4_000796 CN(C)/C=N/S(=O)(=O)c1c(C)noc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E05 compound treatment 1.18669468E8 -5.06E7 -0.63 1.4234569E8 -8620000.0 -0.15 -0.5532 -0.8488 3062520 Maybridge4_000797 CCOc1ccccc1CCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E06 compound treatment 1.07517403E8 -6.18E7 -0.77 1.18965923E8 -3.2E7 -0.55 -0.9351 -0.9856 3179126 Maybridge4_000798 COc1ccc(NS(=O)(=O)c2ccc(Oc3c(C#N)cccc3C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E07 compound treatment 1.299255E8 -3.93E7 -0.49 1.24715422E8 -2.62E7 -0.45 -0.6667 -0.9989 3062522 Maybridge4_000799 Clc1ccc(cc1)S(=O)(=O)NC(=N)N2CCSCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E08 compound treatment 1.20847533E8 -4.84E7 -0.61 1.34857867E8 -1.61E7 -0.28 -0.6245 -0.9361 3179127 Maybridge4_000800 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)c2ccnc(NC(=O)Nc3ccccc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E09 compound treatment 1.15614064E8 -5.37E7 -0.67 1.18513246E8 -3.25E7 -0.56 -0.8687 -0.9955 1521882 Maybridge4_000801 Clc1ccccc1C(=O)NC(=O)OCc2cccc(Oc3ccccc3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E10 compound treatment 1.33472702E8 -3.58E7 -0.45 1.33542478E8 -1.74E7 -0.3 -0.5284 -0.9802 3179128 Maybridge4_000802 O=C(c1ccccc1)n2cc3SCc4ccccc4-c3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E11 compound treatment 1.35604745E8 -3.37E7 -0.42 1.40303599E8 -1.07E7 -0.18 -0.4277 -0.9296 1615025 Maybridge4_000803 Fc1ccc(cc1)C(=O)CCC(=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E12 compound treatment 1.13896596E8 -5.54E7 -0.69 1.3190668E8 -1.91E7 -0.33 -0.7219 -0.9406 1276755 Maybridge4_000804 CN(n1cnc2ccsc2c1=O)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E13 compound treatment 1.48394589E8 -2.09E7 -0.26 1.39272079E8 -1.17E7 -0.2 -0.3267 -0.9912 1254744 Maybridge4_000805 Clc1ccc(NC(=O)NC(=O)C2(CC3CC4CC(C3)C2)C4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E14 compound treatment 1.18011273E8 -5.13E7 -0.64 1.23394881E8 -2.76E7 -0.47 -0.7884 -0.9884 1341148 Maybridge4_000806 O=C(Nc1ccccc1)n2nnc(n2)C3CN(Cc4ccccc4)CN(Cc5ccccc5)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E15 compound treatment 1.3749875E8 -3.18E7 -0.4 1.35853801E8 -1.51E7 -0.26 -0.4647 -0.9781 1687071 Maybridge4_000807 CNC(=O)NCc1c(cccc1N(C)C)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E16 compound treatment 1.47205744E8 -2.21E7 -0.28 1.48150447E8 -2810000.0 -0.05 -0.2298 -0.8179 3179129 Maybridge4_000808 NC(=O)/C(=C/1\SC=C(N1Cc2ccccc2)c3ccccc3)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E17 compound treatment 1.36400799E8 -3.29E7 -0.41 1.52131193E8 1170000.0 0.02 -0.2774 -0.6721 3062558 Maybridge4_000809 CCc1cnc(/N=C/N(C)C)nc1c2c(F)cccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E18 compound treatment 1.74278736E8 5010000.0 0.06 1.71188742E8 2.02E7 0.35 0.2892 0.822 3179130 Maybridge4_000810 Cc1nc(c(s1)c2ccccc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E19 compound treatment 1.55104384E8 -1.42E7 -0.18 1.45575153E8 -5390000.0 -0.09 -0.1909 -0.9534 3062560 Maybridge4_000811 COC(CNC(=S)Nc1ccccc1Cl)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E20 compound treatment 1.58554922E8 -1.07E7 -0.13 1.31955458E8 -1.9E7 -0.33 -0.3251 -0.9235 1542710 Maybridge4_000812 COc1ccc(CCn2nnc3ccccc3c2=O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E21 compound treatment 1.47808982E8 -2.15E7 -0.27 1.45292866E8 -5670000.0 -0.1 -0.259 -0.9051 1303354 Maybridge4_000813 CC(C)NC(=O)NC1CCCCNC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E22 compound treatment 1.51845541E8 -1.74E7 -0.22 1.59207557E8 8240000.0 0.14 -0.0548 -0.2106 3062562 Maybridge4_000814 O=C(N1C(Oc2ccccc12)c3ccc4OCOc4c3)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E23 mock treatment 1.55036511E8 -1.42E7 -0.18 1.45768911E8 -5200000.0 -0.09 -0.1891 -0.9482 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 E24 mock treatment 1.45155181E8 -2.41E7 -0.3 1.29973856E8 -2.1E7 -0.36 -0.468 -0.9963 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F01 compound treatment 1.16744351E8 -5.25E7 -0.66 1.58230271E8 7270000.0 0.12 -0.378 -0.5637 3179131 Maybridge4_000815 CN1CNC(=NC1)SCc2c(C)c(C)c(C)c(C)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F02 compound treatment 1.25513873E8 -4.38E7 -0.55 1.60123927E8 9160000.0 0.16 -0.2773 -0.4857 3062563 Maybridge4_000816 Cn1ncc(C(=O)O)c1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F03 compound treatment 1.2573387E8 -4.35E7 -0.55 1.59725058E8 8760000.0 0.15 -0.2801 -0.4946 3179132 Maybridge4_000817 C(SC1=NCCCN1C2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F04 compound treatment 7.9355265E7 -8.99E7 -1.13 1.39995302E8 -1.1E7 -0.19 -0.9303 -0.8136 3062565 Maybridge4_000818 Cc1cc(SC(=O)N/C=C/c2ccco2)c(C)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F05 compound treatment 1.24669826E8 -4.46E7 -0.56 1.57838786E8 6870000.0 0.12 -0.3124 -0.5464 1151481 Maybridge4_000819 CC(=O)Nc1ccc(cc1)C2Nc3cc(C)ccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F06 compound treatment 1.07258425E8 -6.2E7 -0.78 1.49271392E8 -1690000.0 -0.03 -0.5706 -0.7329 1566379 Maybridge4_000820 O=C1CCC(=O)N1c2sc3CCCCc3c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F07 compound treatment 9.3975837E7 -7.53E7 -0.94 1.43422133E8 -7540000.0 -0.13 -0.7592 -0.7964 1625831 Maybridge4_000821 CC(C)(C)n1c(n[nH]c1=S)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F08 compound treatment 1.25403675E8 -4.39E7 -0.55 1.62839348E8 1.19E7 0.2 -0.2454 -0.4183 3179133 Maybridge4_000822 CCCc1c(cnn1c2ccccc2)C(=O)Sc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F09 compound treatment 1.13363234E8 -5.59E7 -0.7 1.43372748E8 -7590000.0 -0.13 -0.5878 -0.8241 1730421 Maybridge4_000823 CC(NC(=O)c1ccccc1C(=O)NC(C)c2ccc3OCCOc3c2)c4ccc5OCCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F10 compound treatment 1.20823945E8 -4.84E7 -0.61 1.52201304E8 1240000.0 0.02 -0.4148 -0.6821 3062566 Maybridge4_000824 COC(=O)c1sccc1NN2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F11 compound treatment 1.27616064E8 -4.17E7 -0.52 1.65673904E8 1.47E7 0.25 -0.1914 -0.33 1672433 Maybridge4_000825 Cc1ccc(cc1)S(=O)(=O)N(Cc2ccccc2)C(C#N)c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F12 compound treatment 1.21684506E8 -4.76E7 -0.6 1.8338712E8 3.24E7 0.56 -0.0296 -0.0364 3179134 Maybridge4_000826 COC(=O)c1cnc(NN2C(=O)CCC2=O)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F13 compound treatment 1.04276356E8 -6.5E7 -0.82 1.54845377E8 3880000.0 0.07 -0.5295 -0.6473 3179135 Maybridge4_000827 FC(F)(F)c1cccc(NC(=S)N(CCC#N)C2CCCCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F14 compound treatment 1.3657489E8 -3.27E7 -0.41 1.69146862E8 1.82E7 0.31 -0.0699 -0.1358 3062567 Maybridge4_000828 COC(=O)c1c(C)sc2c(cc(=O)[nH]c12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F15 compound treatment 1.25212082E8 -4.41E7 -0.55 1.7341212E8 2.24E7 0.38 -0.1191 -0.1769 3062568 Maybridge4_000829 Clc1cccc(Cl)c1C(=O)N=C2NCCN2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F16 compound treatment 1.43134754E8 -2.61E7 -0.33 1.66691954E8 1.57E7 0.27 -0.0415 -0.0977 1243939 Maybridge4_000830 COC(=O)c1ccsc1NC(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F17 compound treatment 1.36955342E8 -3.23E7 -0.41 1.70671768E8 1.97E7 0.34 -0.0481 -0.0912 3062570 Maybridge4_000831 S=C1CCc2ccccc2N1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F18 compound treatment 1.30651149E8 -3.86E7 -0.48 1.70624395E8 1.97E7 0.34 -0.1046 -0.1773 3179136 Maybridge4_000832 COC(=O)c1sccc1Oc2ccc(cc2NC(=O)c3ccc(Cl)cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F19 compound treatment 1.47607981E8 -2.17E7 -0.27 1.74590334E8 2.36E7 0.4 0.0938 0.1926 3179137 Maybridge4_000833 FC(F)(F)Oc1ccc(NC(=O)N/C(=C(\N=C/c2ccc(Cl)cc2)/C#N)/C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F20 compound treatment 1.26636694E8 -4.26E7 -0.53 1.6761535E8 1.67E7 0.29 -0.1766 -0.2914 1627087 Maybridge4_000834 COC(=O)c1cc(OC)c(OC)cc1NC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F21 compound treatment 8.4095521E7 -8.52E7 -1.07 1.31652728E8 -1.93E7 -0.33 -0.9893 -0.8845 3062571 Maybridge4_000835 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nnc(o2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F22 compound treatment 6.6611615E7 -1.03E8 -1.29 9.1384489E7 -5.96E7 -1.02 -1.6318 -0.9933 3179138 Maybridge4_000836 COc1cc2ncnc(NCCCN3CCOCC3)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F23 mock treatment 9.1070284E7 -7.82E7 -0.98 1.15723699E8 -3.52E7 -0.6 -1.1202 -0.9727 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 F24 mock treatment 5.8987261E7 -1.1E8 -1.38 8.5449286E7 -6.55E7 -1.12 -1.7713 -0.9946 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G01 compound treatment 2.02916425E8 3.36E7 0.42 2.03319366E8 5.24E7 0.9 0.9322 0.941 3179214 Maybridge4_000837 CC(C)(C)C(=N)NS(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G02 compound treatment 1.98463184E8 2.92E7 0.37 1.91169724E8 4.02E7 0.69 0.7456 0.9564 1694181 Maybridge4_000838 O=C(Nc1ccccc1)Nc2ccccc2C(=O)NC3CCSC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G03 compound treatment 1.40448356E8 -2.88E7 -0.36 1.66835123E8 1.59E7 0.27 -0.0636 -0.1405 3179215 Maybridge4_000839 Cc1onc(c1CSc2nncn2C(C)(C)C)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G04 compound treatment 2.00642324E8 3.14E7 0.39 2.05892282E8 5.49E7 0.94 0.9431 0.9253 3062572 Maybridge4_000840 FC(F)(F)c1cccc(c1)C(C#N)c2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G05 compound treatment 1.72376631E8 3110000.0 0.04 1.76358378E8 2.54E7 0.43 0.3349 0.7674 3179216 Maybridge4_000841 CN(C)/C=C/1\CC(=C(O)C1=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G06 compound treatment 2.0789775E8 3.86E7 0.48 1.99833617E8 4.89E7 0.84 0.9342 0.9663 3062573 Maybridge4_000842 CSc1cc(nn1S(=O)(=O)c2ccc(F)cc2F)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G07 compound treatment 2.13737635E8 4.45E7 0.56 2.09941361E8 5.9E7 1.01 1.1083 0.9609 3179217 Maybridge4_000843 Fc1ccc(NC(=O)NC(=O)Cc2c(F)cccc2Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G08 compound treatment 1.99544743E8 3.03E7 0.38 2.03156614E8 5.22E7 0.89 0.9003 0.9274 1112281 Maybridge4_000844 Clc1ccc(cc1)S(=O)(=O)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G09 compound treatment 1.91160481E8 2.19E7 0.27 1.88775066E8 3.78E7 0.65 0.6518 0.9271 3179218 Maybridge4_000845 CC(C)(C)c1nc(NC(=N)N)sc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G10 compound treatment 1.86982017E8 1.77E7 0.22 1.86447486E8 3.55E7 0.61 0.5866 0.907 1361037 Maybridge4_000846 N#CC1CN(Cc2cccs2)CN(Cc3cccs3)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G11 compound treatment 1.93726326E8 2.45E7 0.31 2.06476123E8 5.55E7 0.95 0.8889 0.8902 3062574 Maybridge4_000847 CSCC(CSC)OC(=O)c1c(C)onc1c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G12 compound treatment 1.59739748E8 -9530000.0 -0.12 1.71067086E8 2.01E7 0.34 0.1588 0.4359 3179219 Maybridge4_000848 CN(n1cnc2ccsc2c1=O)S(=O)(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G13 compound treatment 1.5626428E8 -1.3E7 -0.16 1.87440414E8 3.65E7 0.62 0.3261 0.5054 3179220 Maybridge4_000849 CN(C)/C=N/C1=C(C(=O)c2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G14 compound treatment 1.92726968E8 2.35E7 0.29 2.03024449E8 5.21E7 0.89 0.8382 0.8932 3062606 Maybridge4_000850 CC1N(CCc2sccc12)C(=O)c3ccc(cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G15 compound treatment 1.83737486E8 1.45E7 0.18 2.04917992E8 5.4E7 0.92 0.7814 0.8302 1282646 Maybridge4_000851 CN(C(=O)Nc1ccc(Cl)cc1)n2cnc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G16 compound treatment 1.78921364E8 9650000.0 0.12 2.17592586E8 6.66E7 1.14 0.8921 0.7778 3179221 Maybridge4_000852 CCOC(=O)/C(=C/1\SC=C(N1c2c(C)cccc2C)c3ccccc3)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G17 compound treatment 1.98720654E8 2.95E7 0.37 2.14171282E8 6.32E7 1.08 1.0263 0.8977 3062608 Maybridge4_000853 CNC(=O)n1cc(C)c(n1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G18 compound treatment 1.74422833E8 5150000.0 0.06 1.9322186E8 4.23E7 0.72 0.5572 0.7672 1645665 Maybridge4_000854 Cc1ccc(cc1C)c2nn(CCO)c(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G19 compound treatment 1.88658634E8 1.94E7 0.24 2.04820849E8 5.39E7 0.92 0.8239 0.8641 1361478 Maybridge4_000855 Cc1nn(C)c(C)c1Nc2nc(N)n[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G20 compound treatment 2.01239951E8 3.2E7 0.4 2.06625032E8 5.57E7 0.95 0.9573 0.9261 3179222 Maybridge4_000856 CC1CN(CC(C)O1)C(=N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G21 compound treatment 1.60746877E8 -8520000.0 -0.11 1.72311437E8 2.13E7 0.37 0.1828 0.4801 3062610 Maybridge4_000857 Clc1ccc(SS(=O)(=O)CS(=O)(=O)Sc2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G22 compound treatment 1.84046097E8 1.48E7 0.19 2.00775665E8 4.98E7 0.85 0.734 0.8412 3179223 Maybridge4_000858 Clc1ccc(cc1Cl)C2Nc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G23 mock treatment 1.82997702E8 1.37E7 0.17 1.97699385E8 4.67E7 0.8 0.6875 0.8401 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 G24 mock treatment 1.75145118E8 5880000.0 0.07 1.82492677E8 3.15E7 0.54 0.4337 0.7963 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H01 compound treatment 1.76620999E8 7350000.0 0.09 1.81628908E8 3.07E7 0.52 0.4364 0.8188 3062611 Maybridge4_000859 CCN1CNC(=NC1)SCc2c(C)c(C)c(C)c(C)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H02 compound treatment 1.72232653E8 2960000.0 0.04 1.70384395E8 1.94E7 0.33 0.2613 0.7813 3179224 Maybridge4_000860 CCOC(=O)c1sc(SC)nc1NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H03 compound treatment 1.98882267E8 2.96E7 0.37 2.07968723E8 5.7E7 0.98 0.9527 0.9124 1702677 Maybridge4_000861 COc1ccc(CCNC(=O)c2nc3ccccc3c(=O)[nH]2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H04 compound treatment 1.98199521E8 2.89E7 0.36 1.87423741E8 3.65E7 0.62 0.6979 0.9667 1349117 Maybridge4_000862 CCOC(=O)c1cnn(C)c1NS(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H05 compound treatment 2.04918101E8 3.56E7 0.45 1.99920506E8 4.9E7 0.84 0.9088 0.9567 3179225 Maybridge4_000863 COc1ccc(C/N=C/c2ccc(NC(=O)C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H06 compound treatment 1.67846943E8 -1420000.0 -0.02 1.68007953E8 1.7E7 0.29 0.1937 0.6626 3062612 Maybridge4_000864 FC(F)(F)c1ccc(NS(=O)(=O)c2ccc(cc2)N3C(=O)C=CC3=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H07 compound treatment 2.18454003E8 4.92E7 0.62 1.95026376E8 4.41E7 0.75 0.9696 0.995 1216743 Maybridge4_000865 Clc1ccc(cc1)C(=C)NCc2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H08 compound treatment 2.11433581E8 4.22E7 0.53 1.92032115E8 4.11E7 0.7 0.8711 0.9902 3062613 Maybridge4_000866 CSc1cc(nn1S(=O)(=O)c2ccc(C)cc2)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H09 compound treatment 2.19119014E8 4.98E7 0.63 1.95185653E8 4.42E7 0.76 0.9774 0.9955 1649762 Maybridge4_000867 CC1C(OCCN1C(=O)CCN2C(=O)c3ccccc3C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H10 compound treatment 2.12121888E8 4.29E7 0.54 2.00125377E8 4.92E7 0.84 0.9752 0.9766 3062614 Maybridge4_000868 COC(=O)c1scc(C)c1NN2C(=O)C=C(C)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H11 compound treatment 2.04884025E8 3.56E7 0.45 2.07968194E8 5.7E7 0.98 1.0059 0.9373 1683075 Maybridge4_000869 CC1CC(CC(C)(C)C1)N(CCC#N)S(=O)(=O)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H12 compound treatment 2.1477913E8 4.55E7 0.57 2.0412544E8 5.32E7 0.91 1.0472 0.9748 3062615 Maybridge4_000870 COC(=O)c1sc2cc(sc2c1C)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H13 compound treatment 2.2038909E8 5.11E7 0.64 2.03968597E8 5.3E7 0.91 1.095 0.9856 3179226 Maybridge4_000871 Cc1ccc(NC(=S)N(CCC#N)C2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H14 compound treatment 2.14590294E8 4.53E7 0.57 2.15838441E8 6.49E7 1.11 1.1873 0.9516 3062616 Maybridge4_000872 COC(=O)c1cc2c(nn(C)c2s1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H15 compound treatment 2.01917993E8 3.26E7 0.41 1.91896873E8 4.09E7 0.7 0.7851 0.9673 3179227 Maybridge4_000873 COc1ccc(cc1)c2c(N)nc(nc2SC)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H16 compound treatment 1.98652603E8 2.94E7 0.37 2.01161633E8 5.02E7 0.86 0.8682 0.9286 3179228 Maybridge4_000874 CC(=O)N(c1ccc(cc1)C(F)(F)F)S(=O)(=O)c2ccc(cc2)N3C(=O)CCC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H17 compound treatment 1.99416156E8 3.01E7 0.38 1.83162693E8 3.22E7 0.55 0.6571 0.9831 1612694 Maybridge4_000875 Nc1nc2Oc3ccc(Br)cc3C4C(C#N)C(O)(Nc(c1C#N)c42)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H18 compound treatment 1.98196616E8 2.89E7 0.36 2.05949288E8 5.5E7 0.94 0.9221 0.9141 1678485 Maybridge4_000876 Cn1nccc1NS(=O)(=O)c2ccc(NS(=O)(=O)c3ccc(Cl)cc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H19 compound treatment 2.01826326E8 3.26E7 0.41 1.86888333E8 3.59E7 0.61 0.7236 0.9802 3062617 Maybridge4_000877 CC(C)/N=C/c1ccc(cc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H20 compound treatment 2.15104903E8 4.58E7 0.57 1.96349402E8 4.54E7 0.78 0.9559 0.989 3179229 Maybridge4_000878 Cn1nccc1NC(=O)/C=C/C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H21 compound treatment 1.77965297E8 8700000.0 0.11 1.65152946E8 1.42E7 0.24 0.2489 0.9347 3062618 Maybridge4_000879 Cn1ccc(NC(=O)NC(=O)c2c(F)cccc2F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H22 compound treatment 1.41066585E8 -2.82E7 -0.35 1.35505221E8 -1.55E7 -0.26 -0.4373 -0.9898 1656689 Maybridge4_000880 OCCNc1ncnc2sc3CCCCc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H23 mock treatment 1.51627278E8 -1.76E7 -0.22 1.4769302E8 -3270000.0 -0.06 -0.1961 -0.859 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 H24 mock treatment 1.51792953E8 -1.75E7 -0.22 1.3204152E8 -1.89E7 -0.32 -0.3841 -0.9819 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I01 compound treatment 2.15527566E8 4.63E7 0.58 1.83386429E8 3.24E7 0.55 0.8028 0.9998 3062619 Maybridge4_000881 Cc1n[nH]c(C)c1Cc2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I02 compound treatment 2.22353556E8 5.31E7 0.67 2.07470794E8 5.65E7 0.97 1.1548 0.9834 1705532 Maybridge4_000882 O=C(Nc1ccccc1)N2CCCC2c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I03 compound treatment 2.09067893E8 3.98E7 0.5 1.91645418E8 4.07E7 0.7 0.8454 0.9867 3062620 Maybridge4_000883 Nc1ccccc1C2C=NNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I04 compound treatment 2.38947431E8 6.97E7 0.87 2.03916358E8 5.3E7 0.91 1.259 0.9998 3179230 Maybridge4_000884 Fc1c(COC(=O)c2ccccc2)cccc1COC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I05 compound treatment 2.47742099E8 7.85E7 0.98 2.15818816E8 6.49E7 1.11 1.4811 0.9982 3062621 Maybridge4_000885 CSC(=S)N(C)/N=C/c1cc(Cl)cc(Cl)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I06 compound treatment 2.71909657E8 1.03E8 1.29 2.42807423E8 9.18E7 1.57 2.0221 0.9951 3179231 Maybridge4_000886 Cc1nc(NC(=N)NC(=O)Nc2ccc(Cl)cc2)sc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I07 compound treatment 2.37870554E8 6.86E7 0.86 2.14285811E8 6.33E7 1.08 1.375 0.9935 3062622 Maybridge4_000887 Fc1ccccc1C(=O)Oc2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I08 compound treatment 2.32953396E8 6.37E7 0.8 2.0790562E8 5.69E7 0.97 1.2541 0.9951 3179232 Maybridge4_000888 Clc1ccc(cc1)S(=O)(=O)N(Cc2ccccc2)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I09 compound treatment 2.29138105E8 5.99E7 0.75 2.1361162E8 6.26E7 1.07 1.2893 0.9848 1166421 Maybridge4_000889 Fc1cc(CSc2nc3ccccc3s2)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I10 compound treatment 2.26364015E8 5.71E7 0.72 1.99150677E8 4.82E7 0.82 1.0897 0.9975 1473503 Maybridge4_000890 OC(=O)C1(CN(CCc2ccc(Cl)cc2)CN(CCc3ccc(Cl)cc3)C1)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I11 compound treatment 2.59927717E8 9.07E7 1.14 2.03183931E8 5.22E7 0.89 1.4362 0.9929 3179233 Maybridge4_000891 FC(F)(F)c1cc(NC(=O)C2(CC3CC4CC(C3)C2)C4)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I12 compound treatment 2.69126199E8 9.99E7 1.25 1.95210814E8 4.42E7 0.76 1.4213 0.971 3062667 Maybridge4_000892 COc1cccc(OC)c1SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I13 compound treatment 2.29131513E8 5.99E7 0.75 2.11754117E8 6.08E7 1.04 1.2668 0.9872 3062668 Maybridge4_000893 C/C(=N\O)/Cc1ncn(n1)c2cc(C)on2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I14 compound treatment 2.25606997E8 5.63E7 0.71 2.09301227E8 5.83E7 1.0 1.2058 0.9857 3179234 Maybridge4_000894 Clc1ccc(/C=N/N2CCOCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I15 compound treatment 2.20997488E8 5.17E7 0.65 1.89776065E8 3.88E7 0.66 0.9286 0.9999 3062670 Maybridge4_000895 OCCCc1cc(n[nH]1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I16 compound treatment 2.39775305E8 7.05E7 0.88 2.16958268E8 6.6E7 1.13 1.4242 0.9927 3179329 Maybridge4_000896 O=C(CC#N)Nc1ccncc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I17 compound treatment 1.82171625E8 1.29E7 0.16 1.81468923E8 3.05E7 0.52 0.4837 0.8848 3062671 Maybridge4_000897 CN(C)/C=C/C(=O)c1nnn(c1C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I18 compound treatment 2.29134205E8 5.99E7 0.75 2.25585382E8 7.46E7 1.28 1.4342 0.9679 1670735 Maybridge4_000898 OCCn1nc(c2ccc(F)cc2)c3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I19 compound treatment 2.62946866E8 9.37E7 1.18 2.12686654E8 6.17E7 1.06 1.578 0.9986 3179330 Maybridge4_000899 Cc1onc(c1NC(=O)NC2CCSC2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I20 compound treatment 2.23912261E8 5.46E7 0.69 1.86217256E8 3.53E7 0.6 0.9114 0.998 3062672 Maybridge4_000900 CSC1=NNC(N1)c2ccc(cc2)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I21 compound treatment 2.25471789E8 5.62E7 0.71 2.19930381E8 6.9E7 1.18 1.3333 0.9696 3062673 Maybridge4_000901 CSc1nc(/N=C/N(C)C)nn1CCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I22 compound treatment 2.10235437E8 4.1E7 0.51 2.00733473E8 4.98E7 0.85 0.9658 0.9707 1639939 Maybridge4_000902 Cc1ccc(cc1)S(=O)(=O)N2C(Oc3ccccc23)c4ccc(Cl)c(Cl)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I23 mock treatment 2.34869001E8 6.56E7 0.82 2.07666462E8 5.67E7 0.97 1.2682 0.9966 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 I24 mock treatment 2.04210966E8 3.49E7 0.44 1.9052023E8 3.96E7 0.68 0.7887 0.9778 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J01 compound treatment 2.32629174E8 6.34E7 0.79 2.20833843E8 6.99E7 1.2 1.4077 0.9803 3062674 Maybridge4_000903 CCN1CNC(=NC1)SCc2cccc(C#N)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J02 compound treatment 1.97711355E8 2.84E7 0.36 2.13076539E8 6.21E7 1.06 1.0041 0.8953 3179331 Maybridge4_000904 CCCc1c(cnn1C)C(=O)Nc2cc(F)ccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J03 compound treatment 1.82486497E8 1.32E7 0.17 2.16372957E8 6.54E7 1.12 0.909 0.8031 3179332 Maybridge4_000905 CC(O)CN1CNC(=NC1)SCc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J04 compound treatment 2.27077888E8 5.78E7 0.73 2.341061E8 8.31E7 1.42 1.5191 0.9511 3062676 Maybridge4_000906 COC(=O)c1sc(cc1NC(=O)C(F)(F)F)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J05 compound treatment 1.75498481E8 6230000.0 0.08 2.41640682E8 9.07E7 1.55 1.1528 0.7418 3179333 Maybridge4_000907 OCCN1CNC(=NC1)SCc2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J06 compound treatment 2.09917107E8 4.06E7 0.51 2.13401688E8 6.24E7 1.07 1.1163 0.9427 3062677 Maybridge4_000908 COC(=O)c1scc(C)c1S(=O)(=O)Nc2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J07 compound treatment 2.37531875E8 6.83E7 0.86 2.16497881E8 6.55E7 1.12 1.3987 0.9911 1718232 Maybridge4_000909 O=c1n2CCN(Cc3ccccc3)c2nc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J08 compound treatment 2.4393254E8 7.47E7 0.94 2.21520477E8 7.06E7 1.21 1.5163 0.9921 3062678 Maybridge4_000910 CCOC(=O)c1c[nH]c(=S)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J09 compound treatment 2.02435046E8 3.32E7 0.42 2.38880259E8 8.79E7 1.5 1.3583 0.87 3179334 Maybridge4_000911 Cc1cc2ccccc2c(/N=C/c3cc(Br)cc(Br)c3O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J10 compound treatment 2.12426299E8 4.32E7 0.54 2.37243201E8 8.63E7 1.48 1.4271 0.9073 1179240 Maybridge4_000912 COc1ccc(cc1)c2cc(N)nc(N)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J11 compound treatment 2.54476857E8 8.52E7 1.07 2.15957342E8 6.5E7 1.11 1.5425 0.9998 1730849 Maybridge4_000913 Cc1ccc(cc1)S(=O)(=O)N(CCC#N)CC2CCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J12 compound treatment 2.34208497E8 6.49E7 0.81 2.20800673E8 6.98E7 1.2 1.4213 0.9825 3062679 Maybridge4_000914 COC(=O)c1cnc(Nc2ccccc2)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J13 compound treatment 2.15780953E8 4.65E7 0.58 2.22271603E8 7.13E7 1.22 1.2757 0.9429 3179335 Maybridge4_000915 CC(C)c1ccc(NC(=S)Nc2cccc(c2)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J14 compound treatment 1.82345376E8 1.31E7 0.16 2.21710197E8 7.07E7 1.21 0.9723 0.7956 1398467 Maybridge4_000916 COC(=O)c1sccc1S(=O)(=O)N2CCN(CC2)c3ncnc4c(C)csc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J15 compound treatment 1.94354218E8 2.51E7 0.31 1.87727863E8 3.68E7 0.63 0.6675 0.9487 3062680 Maybridge4_000917 COC(=O)c1ccc(/N=C/N(C)C)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J16 compound treatment 2.08317212E8 3.9E7 0.49 2.27831938E8 7.69E7 1.32 1.2768 0.9094 1273229 Maybridge4_000918 COC(=O)c1ccsc1N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J17 compound treatment 1.97332346E8 2.81E7 0.35 1.9730684E8 4.63E7 0.79 0.8099 0.9331 1150677 Maybridge4_000919 COc1ccc2Oc3nc(N)c(C#N)c(N)c3C(C(C#N)C#N)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J18 compound treatment 2.0870535E8 3.94E7 0.49 2.22997234E8 7.2E7 1.23 1.2217 0.9196 3179336 Maybridge4_000920 COC(=O)c1sccc1Oc2ccc(cc2NC(=O)c3ccccc3OC)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J19 compound treatment 2.29031317E8 5.98E7 0.75 2.03315204E8 5.24E7 0.9 1.1638 0.9961 3062681 Maybridge4_000921 C1CC1/N=C/c2ccc(cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J20 compound treatment 1.6168E8 -7590000.0 -0.1 2.05926455E8 5.5E7 0.94 0.5979 0.6323 1209715 Maybridge4_000922 COc1cc(C(=O)NN)c(cc1OC)n2c(C)ccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J21 compound treatment 1.8942918E8 2.02E7 0.25 1.95370113E8 4.44E7 0.76 0.7163 0.8942 3179337 Maybridge4_000923 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)Nc2ccsc2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J22 compound treatment 1.94781867E8 2.55E7 0.32 1.91259575E8 4.03E7 0.69 0.714 0.939 3062682 Maybridge4_000924 Cn1nccc1NC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J23 mock treatment 1.8809941E8 1.88E7 0.24 1.80758373E8 2.98E7 0.51 0.5277 0.9388 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 J24 mock treatment 1.72209662E8 2940000.0 0.04 1.68753301E8 1.78E7 0.3 0.2414 0.787 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K01 compound treatment 2.46115956E8 7.68E7 0.96 2.01679392E8 5.07E7 0.87 1.2955 0.9986 3179338 Maybridge4_000925 CN(C)/C=N/S(=O)(=O)c1c(C)c(C)c(C)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K02 compound treatment 2.52852653E8 8.36E7 1.05 2.04437662E8 5.35E7 0.92 1.3887 0.9977 1131158 Maybridge4_000926 O=S(=O)(N1CCCC1c2cccs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K03 compound treatment 2.53341448E8 8.41E7 1.05 2.17372349E8 6.64E7 1.14 1.5496 0.9993 1673268 Maybridge4_000927 COc1ccc(CCn2cnn3c(=O)c4ccccc4nc3c2=O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K04 compound treatment 2.36087493E8 6.68E7 0.84 2.07108236E8 5.61E7 0.96 1.2723 0.9977 3062684 Maybridge4_000928 Clc1ccc(Sc2c(C#N)cccc2C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K05 compound treatment 2.55814482E8 8.65E7 1.09 1.64005288E8 1.3E7 0.22 0.9255 0.835 3179339 Maybridge4_000929 Cc1onc(c1C(=O)NC(=N)N2CCCC2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K06 compound treatment 2.51254663E8 8.2E7 1.03 2.21649958E8 7.07E7 1.21 1.5828 0.9967 3062686 Maybridge4_000930 NC(=O)N/C(=N\O)/CSc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K07 compound treatment 2.56109046E8 8.68E7 1.09 2.28911738E8 7.79E7 1.33 1.7138 0.9949 3179340 Maybridge4_000931 Clc1ccc(SCC(=N)NS(=O)(=O)c2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K08 compound treatment 2.50830025E8 8.16E7 1.02 2.19871703E8 6.89E7 1.18 1.5575 0.9975 3179341 Maybridge4_000932 CCN(S(=O)(=O)c1ccc(F)cc1)S(=O)(=O)c2c(C)c(C)c(C)c(C)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K09 compound treatment 2.55931923E8 8.67E7 1.09 2.23904279E8 7.29E7 1.25 1.6516 0.9976 3062687 Maybridge4_000933 CS(=O)(=O)Cc1cc(F)cc2COCOc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K10 compound treatment 2.62047183E8 9.28E7 1.16 2.37414765E8 8.65E7 1.48 1.8694 0.9929 1659719 Maybridge4_000934 Fc1cccc(Cl)c1CSC2=CC(=O)CC(C2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K11 compound treatment 2.45338959E8 7.61E7 0.95 2.31281173E8 8.03E7 1.37 1.6469 0.9841 3179342 Maybridge4_000935 Cc1c(C)c(C)c(C#CCOC2CCCCO2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K12 compound treatment 2.56720748E8 8.75E7 1.1 1.8258442E8 3.16E7 0.54 1.1585 0.947 3179343 Maybridge4_000936 COc1cccc(OC)c1C(=O)c2cc[n+](C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K13 compound treatment 2.46654836E8 7.74E7 0.97 2.58781774E8 1.08E8 1.85 1.9915 0.955 3062688 Maybridge4_000937 N#Cc1c(oc(c1c2ccc(C#N)cc2)n3cccc3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K14 compound treatment 2.63026695E8 9.38E7 1.18 2.45319793E8 9.44E7 1.62 1.9738 0.9879 3179344 Maybridge4_000938 Clc1ccc(/C=N/N2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K15 compound treatment 2.35362496E8 6.61E7 0.83 1.9319702E8 4.22E7 0.72 1.0975 0.9977 3062689 Maybridge4_000939 CN(C)/C=N/c1c(cnn1C)c2nc(cs2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K16 compound treatment 2.50018748E8 8.07E7 1.01 2.22554795E8 7.16E7 1.23 1.5828 0.9955 1505900 Maybridge4_000940 Clc1ccc(Cl)c(c1)S(=O)(=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K17 compound treatment 2.45083796E8 7.58E7 0.95 1.59516785E8 8550000.0 0.15 0.776 0.8065 3179345 Maybridge4_000941 CN(C1CC2CC1C=C2)C(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K18 compound treatment 2.42094283E8 7.28E7 0.91 1.31723431E8 -1.92E7 -0.33 0.4131 0.4254 1333053 Maybridge4_000942 N1C(Nc2ccccc12)c3c[nH]c4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K19 compound treatment 2.53053562E8 8.38E7 1.05 2.46855768E8 9.59E7 1.64 1.9039 0.9768 3062581 Maybridge4_000943 CC(C)(C)c1cc2N=CN3CCN=C3n2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K20 compound treatment 2.37809713E8 6.85E7 0.86 2.11228971E8 6.03E7 1.03 1.3374 0.9959 3179346 Maybridge4_000944 CN(CCC#N)c1ccc(/C=C/2\CC/C(=C\c3ccc(cc3)N(C)CCC#N)/C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K21 compound treatment 2.29393769E8 6.01E7 0.75 2.16072869E8 6.51E7 1.11 1.3214 0.9819 3062583 Maybridge4_000945 CC1SCC(CS1)NC(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K22 compound treatment 2.58689627E8 8.94E7 1.12 1.91230345E8 4.03E7 0.69 1.2806 0.9727 3179347 Maybridge4_000946 COc1ccc(cc1)C2Nc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K23 mock treatment 2.38850643E8 6.96E7 0.87 2.08727259E8 5.78E7 0.99 1.3164 0.9981 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 K24 mock treatment 2.26143892E8 5.69E7 0.71 2.03989366E8 5.3E7 0.91 1.1463 0.9929 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L01 compound treatment 2.345288E8 6.53E7 0.82 1.9428458E8 4.33E7 0.74 1.1032 0.9988 3062584 Maybridge4_000947 CN1CNC(=NC1)SCc2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L02 compound treatment 2.31193729E8 6.19E7 0.78 2.21787981E8 7.08E7 1.21 1.4065 0.9769 3179348 Maybridge4_000948 Cn1cc(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(n1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L03 compound treatment 2.36257276E8 6.7E7 0.84 1.37686224E8 -1.33E7 -0.23 0.4335 0.4979 3062585 Maybridge4_000949 CN(C)/N=C(\N)/c1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L04 compound treatment 2.67003688E8 9.77E7 1.23 1.3166833E8 -1.93E7 -0.33 0.6334 0.4988 3179349 Maybridge4_000950 NC(=O)c1sc(cc1NC(=O)c2cccs2)c3ccsc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L05 compound treatment 2.44067218E8 7.48E7 0.94 1.43220234E8 -7740000.0 -0.13 0.5697 0.6012 3062586 Maybridge4_000951 CSC1=NCN(CCCO)CN1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L06 compound treatment 2.58946294E8 8.97E7 1.12 2.3175796E8 8.08E7 1.38 1.7734 0.9947 3179350 Maybridge4_000952 FC(F)(F)c1cc(=O)oc2cc(ccc12)N3C(=O)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L07 compound treatment 2.49961087E8 8.07E7 1.01 2.10270672E8 5.93E7 1.02 1.4336 1.0 3062588 Maybridge4_000953 Brc1ccc(CSC2=Nc3ccccc3C(=O)NN2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L08 compound treatment 1.56412313E8 -1.29E7 -0.16 2.06211441E8 5.52E7 0.95 0.5547 0.5782 3179351 Maybridge4_000954 COc1ccc(CC(=O)n2nc(cc2SC)c3ccc(F)cc3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L09 compound treatment 1.46915813E8 -2.24E7 -0.28 1.91687946E8 4.07E7 0.7 0.2946 0.3921 3062590 Maybridge4_000955 COc1ccc(cc1OC)c2sc(/N=C/c3cccs3)c(C#N)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L10 compound treatment 1.57895954E8 -1.14E7 -0.14 1.81342148E8 3.04E7 0.52 0.2668 0.4948 3179352 Maybridge4_000956 COC(=O)c1cnc(nc1C(F)(F)F)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L11 compound treatment 2.4433289E8 7.51E7 0.94 1.40109848E8 -1.09E7 -0.19 0.5344 0.5568 1310115 Maybridge4_000957 N#CCc1ccc(NC2(CCCCC2)C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L12 compound treatment 2.27267726E8 5.8E7 0.73 1.56985817E8 6020000.0 0.1 0.5873 0.7993 3062591 Maybridge4_000958 FC(F)(F)c1nc(Sc2ccc(Cl)cc2)ncc1C(=O)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L13 compound treatment 2.26175072E8 5.69E7 0.71 2.30188221E8 7.92E7 1.36 1.4637 0.9551 3179450 Maybridge4_000959 CC1CN(CC(C)O1)C(=S)Nc2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L14 compound treatment 2.19536825E8 5.03E7 0.63 1.47374814E8 -3590000.0 -0.06 0.4024 0.6352 3179451 Maybridge4_000960 Cc1csc2c(ncnc12)N3CCN(CC3)C(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L15 compound treatment 2.38683904E8 6.94E7 0.87 2.08186835E8 5.72E7 0.98 1.3084 0.9983 3062624 Maybridge4_000961 Clc1ccc2sc(Sc3ccccc3)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L16 compound treatment 1.37987373E8 -3.13E7 -0.39 2.34770132E8 8.38E7 1.43 0.7369 0.4955 3179452 Maybridge4_000962 C(N1CCC(CC1)Nc2ncnc3sccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L17 compound treatment 2.39219592E8 6.99E7 0.88 2.01051126E8 5.01E7 0.86 1.2267 0.9999 1533957 Maybridge4_000963 CSCCC1NC(=O)NC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L18 compound treatment 2.32597011E8 6.33E7 0.79 2.32276766E8 8.13E7 1.39 1.546 0.9646 3179453 Maybridge4_000964 COC(=O)c1sccc1Oc2ccc(cc2NC(=O)Nc3ccc(Cl)cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L19 compound treatment 1.92150609E8 2.29E7 0.29 2.42713196E8 9.17E7 1.57 1.3135 0.8227 3062627 Maybridge4_000965 CN(C)c1ccsc1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L20 compound treatment 2.33126612E8 6.39E7 0.8 2.15867845E8 6.49E7 1.11 1.352 0.9871 3179454 Maybridge4_000966 COc1cc2ncnc(SCC(=O)NN)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L21 compound treatment 2.24632755E8 5.54E7 0.69 1.96322455E8 4.54E7 0.78 1.0401 0.9985 3062629 Maybridge4_000967 CNC(=O)c1c(C)csc1NC(=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L22 compound treatment 1.89601808E8 2.03E7 0.26 1.83986814E8 3.3E7 0.57 0.5801 0.9354 1534695 Maybridge4_000968 CCN(CC)c1ncnc2sc3CCCCc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L23 mock treatment 2.14950819E8 4.57E7 0.57 1.9432714E8 4.34E7 0.74 0.9301 0.9918 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 L24 mock treatment 1.958134E8 2.65E7 0.33 1.76706203E8 2.57E7 0.44 0.547 0.9905 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M01 compound treatment 1.74385109E8 5120000.0 0.06 1.35636189E8 -1.53E7 -0.26 -0.1402 -0.5189 3062631 Maybridge4_000969 COc1ccc(OC)c(c1)S(=O)(=O)/N=C/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M02 compound treatment 1.7921747E8 9950000.0 0.12 1.32047506E8 -1.89E7 -0.32 -0.1407 -0.4055 3179455 Maybridge4_000970 Cc1nn(C)c2SC(=NS(=O)(=O)c12)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M03 compound treatment 1.77947554E8 8680000.0 0.11 1.36207383E8 -1.48E7 -0.25 -0.1016 -0.3695 3062632 Maybridge4_000971 Cn1c(S)nnc1C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M04 compound treatment 1.72975626E8 3710000.0 0.05 1.37504276E8 -1.35E7 -0.23 -0.1301 -0.5533 3179456 Maybridge4_000972 FC(F)(F)c1ccc(CNC(=O)c2ccc(Cl)cc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M05 compound treatment 1.66968611E8 -2300000.0 -0.03 1.4013222E8 -1.08E7 -0.19 -0.1515 -0.8075 3062633 Maybridge4_000973 CC1CN(CC(C)O1)C(=N)NS(=O)(=O)c2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M06 compound treatment 1.63842778E8 -5430000.0 -0.07 1.33489337E8 -1.75E7 -0.3 -0.2597 -0.8464 1452088 Maybridge4_000974 CN(C)c1cc(oc(=O)c1Cl)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M07 compound treatment 1.71449228E8 2180000.0 0.03 1.41892658E8 -9070000.0 -0.16 -0.0905 -0.5738 3062634 Maybridge4_000975 Fc1cccc(Cl)c1CSC(=S)N2CCSCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M08 compound treatment 1.61622966E8 -7650000.0 -0.1 1.31446027E8 -1.95E7 -0.33 -0.3041 -0.8748 3179457 Maybridge4_000976 CN(C)/C=C/C(=O)C(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M09 compound treatment 1.57454463E8 -1.18E7 -0.15 1.43067774E8 -7900000.0 -0.14 -0.2004 -0.9989 3179458 Maybridge4_000977 Cc1cc(C)n(n1)C2=NCCN2S(=O)(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M10 compound treatment 1.74019493E8 4750000.0 0.06 1.51768395E8 804000.0 0.01 0.0519 0.8481 1473043 Maybridge4_000978 CC(NS(=O)(=O)c1ccc(Oc2cccc(Cl)c2C#N)cc1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M11 compound treatment 1.89484101E8 2.02E7 0.25 1.57568972E8 6600000.0 0.11 0.2592 0.9338 3179459 Maybridge4_000979 Cc1ccc(C)n1c2ccsc2COC(=O)Nc3c(C)onc3c4c(F)cccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M12 compound treatment 2.09929846E8 4.07E7 0.51 1.78089185E8 2.71E7 0.46 0.689 0.9989 3062636 Maybridge4_000980 CC(=O)n1nccc1c2nccnc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M13 compound treatment 2.36886453E8 6.76E7 0.85 1.81789491E8 3.08E7 0.53 0.9729 0.9739 3062637 Maybridge4_000981 Cc1cc(no1)n2cnc(n2)c3cnoc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M14 compound treatment 2.42106811E8 7.28E7 0.91 1.9375222E8 4.28E7 0.73 1.164 0.994 1215853 Maybridge4_000982 COC(=O)c1cccc(NC(=O)NC(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M15 compound treatment 2.33009749E8 6.37E7 0.8 1.768942E8 2.59E7 0.44 0.8793 0.9614 1711378 Maybridge4_000983 Cn1ncc(NCCc2ccncc2)c(Cl)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M16 compound treatment 2.01625715E8 3.24E7 0.41 1.6780423E8 1.68E7 0.29 0.4908 0.9859 1176335 Maybridge4_000984 CC1CCN(CC1)C(=O)C(C#N)C(=S)Nc2ccc(C)cc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M17 compound treatment 1.98083015E8 2.88E7 0.36 1.54672389E8 3710000.0 0.06 0.3005 0.8187 3179460 Maybridge4_000985 CN(C)/C=C/C(=O)c1sc(=S)n(CCc2ccc(Cl)cc2)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M18 compound treatment 2.09548111E8 4.03E7 0.51 1.06298925E8 -4.47E7 -0.76 -0.1834 -0.2001 1468395 Maybridge4_000986 COc1ccc(cc1OC)c2c(C)n(C)c(C)c2c3ccc(OC)c(OC)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M19 compound treatment 1.88972163E8 1.97E7 0.25 1.53126681E8 2160000.0 0.04 0.2009 0.804 3179461 Maybridge4_000987 Cc1ccc(C)n1c2ccccc2C3C=NNC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M20 compound treatment 2.81744457E8 1.12E8 1.41 2.16421958E8 6.55E7 1.12 1.79 0.9935 1563316 Maybridge4_000988 CNc1ccccc1C(=O)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M21 compound treatment 1.95724213E8 2.65E7 0.33 1.60041565E8 9080000.0 0.16 0.3445 0.9402 3179462 Maybridge4_000989 CC1SCC(CS1)NC(=O)c2c(C)onc2c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M22 compound treatment 2.03669037E8 3.44E7 0.43 1.80835247E8 2.99E7 0.51 0.6667 0.9964 3062639 Maybridge4_000990 Cc1c(C)c(C)c(CN)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M23 mock treatment 1.91329189E8 2.21E7 0.28 1.50522541E8 -442000.0 -0.01 0.1903 0.6875 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 M24 mock treatment 1.8169992E8 1.24E7 0.16 1.63165458E8 1.22E7 0.21 0.2579 0.9896 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N01 compound treatment 1.65308051E8 -3960000.0 -0.05 1.4352354E8 -7440000.0 -0.13 -0.1252 -0.9158 3062690 Maybridge4_000991 CSC1=NCCCN1C(=O)c2ccccc2I 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N02 compound treatment 1.60562608E8 -8710000.0 -0.11 1.54892088E8 3930000.0 0.07 -0.0297 -0.2315 3179463 Maybridge4_000992 CCOC(=O)c1cn(CC(=O)NN)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N03 compound treatment 1.62412965E8 -6860000.0 -0.09 1.53796117E8 2830000.0 0.05 -0.0265 -0.2689 3062691 Maybridge4_000993 CC(C)(C)N1CNC(=NC1)SCc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N04 compound treatment 1.84486424E8 1.52E7 0.19 1.49132326E8 -1830000.0 -0.03 0.1128 0.5831 3179464 Maybridge4_000994 NC(=O)c1sc(cc1NC(=O)/C=C/c2ccsc2)c3ccsc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N05 compound treatment 1.61031926E8 -8240000.0 -0.1 1.40876623E8 -1.01E7 -0.17 -0.1952 -0.9699 3179465 Maybridge4_000995 COc1cc(/C=N/N(C)C(=S)Nc2cccc(Cl)c2C)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N06 compound treatment 1.27560228E8 -4.17E7 -0.52 1.22386932E8 -2.86E7 -0.49 -0.7159 -0.9994 3062692 Maybridge4_000996 FC(F)(F)c1c(cnn1c2ccccc2)C(=O)Sc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N07 compound treatment 1.53101911E8 -1.62E7 -0.2 1.43749713E8 -7210000.0 -0.12 -0.2307 -0.9717 3179466 Maybridge4_000997 Cc1ccc2N(CCCc2c1)C(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N08 compound treatment 1.53348861E8 -1.59E7 -0.2 1.46647443E8 -4320000.0 -0.07 -0.1935 -0.9085 1622973 Maybridge4_000998 CC1CN(CC(C)O1)c2ncnc3c(C)csc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N09 compound treatment 1.61722186E8 -7550000.0 -0.09 1.44348808E8 -6620000.0 -0.11 -0.147 -0.996 1148536 Maybridge4_000999 COc1cc(cc(OC)c1OC)C(=O)N2CCCN3C2c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N10 compound treatment 1.49814466E8 -1.95E7 -0.24 1.43131395E8 -7830000.0 -0.13 -0.2674 -0.9602 3062693 Maybridge4_001000 COC(=O)c1c(C)sc2cc(sc12)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N11 compound treatment 1.48317884E8 -2.1E7 -0.26 1.39137263E8 -1.18E7 -0.2 -0.329 -0.9917 1697786 Maybridge4_001001 COc1cc(cc(OC)c1OC)C(=O)N(CCC#N)C2CC(C)CC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N12 compound treatment 1.4672538E8 -2.25E7 -0.28 1.45474451E8 -5490000.0 -0.09 -0.2664 -0.894 3062695 Maybridge4_001002 CC1CN(CC(C)O1)c2ncc(C(=O)OCC3CC3)c(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N13 compound treatment 1.57783926E8 -1.15E7 -0.14 1.50576877E8 -388000.0 -0.01 -0.1066 -0.7389 3179467 Maybridge4_001003 CC1CN(CC(C)O1)C(=S)Nc2c(C)cccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N14 compound treatment 1.35064989E8 -3.42E7 -0.43 1.34980239E8 -1.6E7 -0.27 -0.4969 -0.9764 3179468 Maybridge4_001004 Cc1csc2ncnc(N3CCN(CC3)C(=O)Nc4ccc(OC(F)(F)F)cc4)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N15 compound treatment 8.9575984E7 -7.97E7 -1.0 1.48655797E8 -2310000.0 -0.04 -0.7349 -0.7345 3062698 Maybridge4_001005 CN(C)C(=O)Oc1ccc2nnc3ccnn3c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N16 compound treatment 9.1639559E7 -7.76E7 -0.97 1.58732834E8 7770000.0 0.13 -0.5946 -0.6049 1412351 Maybridge4_001006 C1CCN(C1)c2ncnc3sccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N17 compound treatment 1.67423142E8 -1850000.0 -0.02 1.57356136E8 6390000.0 0.11 0.061 0.5453 3179469 Maybridge4_001007 CC(C)CC1NC(=O)N(C)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N18 compound treatment 1.66338901E8 -2930000.0 -0.04 1.46745674E8 -4220000.0 -0.07 -0.0771 -0.9509 1428548 Maybridge4_001008 Cn1nccc1N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N19 compound treatment 8.3455146E7 -8.58E7 -1.08 1.45036653E8 -5930000.0 -0.1 -0.833 -0.7703 3179470 Maybridge4_001009 C/C(=N\O)/CSC(=O)c1c(C)onc1c2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N20 compound treatment 1.62840509E8 -6430000.0 -0.08 1.54705379E8 3740000.0 0.06 -0.0117 -0.1141 3062700 Maybridge4_001010 CNC(=S)NCc1ccco1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N21 compound treatment 1.64149077E8 -5120000.0 -0.06 1.42710827E8 -8250000.0 -0.14 -0.1453 -0.9364 3179471 Maybridge4_001011 Cn1ccc(NC(=O)Nc2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N22 compound treatment 1.4796651E8 -2.13E7 -0.27 1.17597685E8 -3.34E7 -0.57 -0.5928 -0.9401 1103188 Maybridge4_001012 C(CNc1ncnc2sc3CCCCc3c12)CN4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N23 mock treatment 1.63283369E8 -5990000.0 -0.08 1.40357359E8 -1.06E7 -0.18 -0.1815 -0.9237 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 N24 mock treatment 1.54174506E8 -1.51E7 -0.19 1.21567809E8 -2.94E7 -0.5 -0.4897 -0.9108 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O01 compound treatment 2.31098876E8 6.18E7 0.78 2.02709284E8 5.17E7 0.89 1.1748 0.9978 3062702 Maybridge4_001013 CN(C)/C=N/S(=O)(=O)c1ccc(Cl)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O02 compound treatment 2.21259442E8 5.2E7 0.65 1.90081846E8 3.91E7 0.67 0.9347 0.9999 3179472 Maybridge4_001014 Cc1nn(C)c2SC(=NS(=O)(=O)c12)SCc3c(F)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O03 compound treatment 2.34603438E8 6.53E7 0.82 1.9997936E8 4.9E7 0.84 1.1728 0.9999 3062703 Maybridge4_001015 CN(C)/C=C/C(=O)c1cc(F)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O04 compound treatment 2.3781385E8 6.85E7 0.86 2.13286032E8 6.23E7 1.07 1.3624 0.9943 3179473 Maybridge4_001016 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)OC2CCSC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O05 compound treatment 2.21807696E8 5.25E7 0.66 1.96391246E8 4.54E7 0.78 1.0159 0.9966 3062704 Maybridge4_001017 CC1CN(CC(C)O1)C(=N)NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O06 compound treatment 2.34246976E8 6.5E7 0.82 2.09630206E8 5.87E7 1.0 1.2865 0.9946 3179474 Maybridge4_001018 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)c2ccn[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O07 compound treatment 2.33350024E8 6.41E7 0.8 1.95554977E8 4.46E7 0.76 1.1081 0.9997 3179571 Maybridge4_001019 Fc1cccc(Cl)c1CCNC(=O)NC(=O)Cc2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O08 compound treatment 2.37879302E8 6.86E7 0.86 1.96802452E8 4.58E7 0.78 1.1634 0.9989 3062705 Maybridge4_001020 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)S(=O)(=O)n2cccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O09 compound treatment 2.06116062E8 3.68E7 0.46 1.8971485E8 3.88E7 0.66 0.7959 0.9844 3179572 Maybridge4_001021 CS/C(=N/S(=O)(=O)c1ccccc1)/NCCc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O10 compound treatment 2.22118318E8 5.28E7 0.66 1.87501222E8 3.65E7 0.63 0.911 0.9996 1316388 Maybridge4_001022 Clc1ccc(cc1)S(=O)(=O)NCC2CN(Cc3ccccc3)CN(Cc4ccccc4)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O11 compound treatment 2.38922871E8 6.97E7 0.87 2.06017511E8 5.51E7 0.94 1.2842 0.9993 1687690 Maybridge4_001023 Clc1cc(Cl)cc(OC(=O)C2(CC3CC4CC(C3)C2)C4)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O12 compound treatment 2.31923253E8 6.27E7 0.79 2.04605661E8 5.36E7 0.92 1.205 0.997 3063461 Maybridge4_001024 Cc1nc(CSCc2ccc(Cl)cc2Cl)cs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O13 compound treatment 2.35914973E8 6.66E7 0.84 2.0921266E8 5.82E7 1.0 1.2962 0.9962 1553397 Maybridge4_001025 O=C(Nc1ccccc1)OC(CSc2ccccn2)CSc3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O14 compound treatment 2.39365103E8 7.01E7 0.88 2.21223203E8 7.03E7 1.2 1.4722 0.9882 1170892 Maybridge4_001026 COC(=O)c1cccc(NC(=O)Nc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O15 compound treatment 2.33593159E8 6.43E7 0.81 2.14362983E8 6.34E7 1.09 1.338 0.9894 1387636 Maybridge4_001027 CN(C)c1cccc(N(C)C)c1CNS(=O)(=O)c2cc(C)c(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O16 compound treatment 1.93797816E8 2.45E7 0.31 1.76782446E8 2.58E7 0.44 0.5301 0.9843 1136580 Maybridge4_001028 Clc1ccccc1NC(=S)C(C#N)C(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O17 compound treatment 2.40782587E8 7.15E7 0.9 2.18760399E8 6.78E7 1.16 1.455 0.9919 3063462 Maybridge4_001029 CN(C1CC2CC1C=C2)S(=O)(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O18 compound treatment 2.31172045E8 6.19E7 0.78 2.06934894E8 5.6E7 0.96 1.2266 0.9946 1238489 Maybridge4_001030 Cc1cc2NC(=O)c3ccccc3C(=Nc2cc1C)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O19 compound treatment 2.21546493E8 5.23E7 0.66 2.20556154E8 6.96E7 1.19 1.3061 0.9605 3063463 Maybridge4_001031 CN(C)/C=N/c1ccccc1C2C=NNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O20 compound treatment 2.39903381E8 7.06E7 0.89 2.19565035E8 6.86E7 1.17 1.4569 0.9904 3179573 Maybridge4_001032 S=C1NCCN1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O21 compound treatment 2.13257701E8 4.4E7 0.55 1.91379809E8 4.04E7 0.69 0.8794 0.9937 1607454 Maybridge4_001033 CC1=C(N2CCOCC2)C(=NCCN1)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O22 compound treatment 2.26440182E8 5.72E7 0.72 2.07311193E8 5.63E7 0.96 1.1892 0.9894 1293246 Maybridge4_001034 Cc1nc2ccccc2n1C3CC(=O)N(C3=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O23 mock treatment 2.26659305E8 5.74E7 0.72 2.07232941E8 5.63E7 0.96 1.1901 0.9897 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 O24 mock treatment 2.31877466E8 6.26E7 0.79 1.9548939E8 4.45E7 0.76 1.0943 0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P01 compound treatment 2.24646991E8 5.54E7 0.69 2.04220489E8 5.33E7 0.91 1.1358 0.991 1354193 Maybridge4_001035 OCCN1CNC(=S)NC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P02 compound treatment 2.22669599E8 5.34E7 0.67 1.93982888E8 4.3E7 0.74 0.9944 0.9989 3179574 Maybridge4_001036 FC(F)(F)c1cc(NC(=O)N/C=C/c2ccsc2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P03 compound treatment 2.25518004E8 5.62E7 0.71 1.96578722E8 4.56E7 0.78 1.0511 0.9987 3063464 Maybridge4_001037 C(SC1=NCN(Cc2ccccc2)CN1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P04 compound treatment 2.23010961E8 5.37E7 0.67 1.99902328E8 4.89E7 0.84 1.0691 0.9942 3179575 Maybridge4_001038 COC(=O)c1sccc1N2C(=O)C=C(C)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P05 compound treatment 2.21337446E8 5.21E7 0.65 1.92462944E8 4.15E7 0.71 0.9642 0.9991 3179576 Maybridge4_001039 CN(/N=C/c1ccccn1)C(=S)Nc2ccc(C)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P06 compound treatment 2.32881561E8 6.36E7 0.8 2.00459375E8 4.95E7 0.85 1.1634 0.9996 1429512 Maybridge4_001040 CCCc1c(NC(=O)Nc2ccc(Cl)cc2Cl)cnn1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P07 compound treatment 2.29243212E8 6.0E7 0.75 1.93672877E8 4.27E7 0.73 1.0489 0.9999 1160255 Maybridge4_001041 N#CC1(CCCCCC1)NC(Cc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P08 compound treatment 2.256729E8 5.64E7 0.71 2.01419812E8 5.05E7 0.86 1.111 0.9951 1344462 Maybridge4_001042 CC(C)Nc1ncnc2c(C)csc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P09 compound treatment 2.28142795E8 5.89E7 0.74 1.79197181E8 2.82E7 0.48 0.864 0.9789 3179577 Maybridge4_001043 COc1cc(cc(OC)c1OC)C2NN=C3C2N4CCC3CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P10 compound treatment 2.29912666E8 6.06E7 0.76 2.02513221E8 5.15E7 0.88 1.1619 0.9973 3063465 Maybridge4_001044 FC(F)(F)c1ccc(NC(=O)C2CCc3ccccc3O2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P11 compound treatment 2.18271171E8 4.9E7 0.61 1.94522774E8 4.36E7 0.75 0.9619 0.9954 1463450 Maybridge4_001045 COc1cc(cc(OC)c1OC)C(=O)N(CCC#N)Cc2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P12 compound treatment 1.74008983E8 4740000.0 0.06 1.92063021E8 4.11E7 0.7 0.5395 0.7641 3179578 Maybridge4_001046 CSc1cc(nn1S(=O)(=O)c2cccc(c2)C(F)(F)F)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P13 compound treatment 1.9755698E8 2.83E7 0.35 1.85399156E8 3.44E7 0.59 0.6677 0.9705 3063466 Maybridge4_001047 COc1cccc(NC(=S)N(CCC#N)/N=C/c2ccc3OCOc3c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P14 compound treatment 1.87590535E8 1.83E7 0.23 1.71247632E8 2.03E7 0.35 0.408 0.9799 1234970 Maybridge4_001048 Cc1csc2ncnc(N3CCN(CC3)C(=S)Nc4ccc(F)cc4F)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P15 compound treatment 2.07390985E8 3.81E7 0.48 1.91460088E8 4.05E7 0.69 0.8283 0.9836 1069786 Maybridge4_001049 NNC(=O)OC1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P16 compound treatment 2.12685314E8 4.34E7 0.54 1.87458651E8 3.65E7 0.62 0.8268 0.9977 3179579 Maybridge4_001050 CCOC(=O)c1cnc(Sc2ccc(F)c(Cl)c2)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P17 compound treatment 2.08680611E8 3.94E7 0.49 1.74661131E8 2.37E7 0.41 0.6364 0.9952 3063467 Maybridge4_001051 Sc1nc(ccc1C#N)c2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P18 compound treatment 2.29360375E8 6.01E7 0.75 1.95595137E8 4.46E7 0.76 1.0732 1.0 1377109 Maybridge4_001052 CCOC(=O)c1cc(=O)c2cc(Cl)ccc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P19 compound treatment 2.1725524E8 4.8E7 0.6 1.89380097E8 3.84E7 0.66 0.8906 0.999 1695486 Maybridge4_001053 CC1CCCN(C1)c2ccc3nncn3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P20 compound treatment 2.13187763E8 4.39E7 0.55 1.83702522E8 3.27E7 0.56 0.7858 1.0 3063468 Maybridge4_001054 Cn1ncc(Br)c1NC(=O)CSc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P21 compound treatment 2.04084847E8 3.48E7 0.44 1.64558691E8 1.36E7 0.23 0.4734 0.9566 3179580 Maybridge4_001055 COC(=O)c1sccc1NS(=O)(=O)c2ccc(F)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P22 compound treatment 1.74541262E8 5270000.0 0.07 1.43582858E8 -7380000.0 -0.13 -0.0426 -0.2986 1127720 Maybridge4_001056 CCC(C)Nc1ncnc2cc(OC)c(OC)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P23 mock treatment 2.00232869E8 3.1E7 0.39 1.53104576E8 2140000.0 0.04 0.3006 0.7704 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2051 P24 mock treatment 1.7063711E8 1370000.0 0.02 1.42917503E8 -8050000.0 -0.14 -0.0853 -0.6143 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A01 compound treatment 1.21590482E8 -5.56E7 -0.7 1.15384267E8 -5.87E7 -1.01 -1.2043 -0.9841 1118682 Maybridge4_001057 Cc1cc(NS(=O)(=O)c2ccc(NC(=O)c3ccco3)cc2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A02 compound treatment 1.30144401E8 -4.71E7 -0.59 1.20121517E8 -5.4E7 -0.92 -1.071 -0.9766 1260001 Maybridge4_001058 O=C(CC1(CC2CC3CC(C2)C1)C3)NC4CCN(Cc5ccccc5)CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A03 compound treatment 1.24681854E8 -5.26E7 -0.66 1.19694341E8 -5.44E7 -0.93 -1.1247 -0.9857 3063469 Maybridge4_001059 Cn1ncc(C(=O)Sc2ccc(Cl)cc2)c1n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A04 compound treatment 1.35630745E8 -4.16E7 -0.52 1.1870891E8 -5.54E7 -0.95 -1.0395 -0.9604 3179581 Maybridge4_001060 Oc1cc(nc(SCC(=O)c2ccc(Cl)s2)n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A05 compound treatment 1.49759637E8 -2.75E7 -0.34 1.48384998E8 -2.57E7 -0.44 -0.5549 -0.9927 3063470 Maybridge4_001061 FC(F)(F)c1ccnc(Sc2ccccc2NC(=O)Nc3ccccc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A06 compound treatment 1.55773836E8 -2.15E7 -0.27 1.41017294E8 -3.31E7 -0.57 -0.5908 -0.9422 3179582 Maybridge4_001062 CC(C)(C)c1cc(C(=O)N2CCN(CC2)c3ccc(cn3)C(F)(F)F)n(Cc4ccc(F)cc4)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A07 compound treatment 1.59772452E8 -1.75E7 -0.22 1.73265185E8 -832000.0 -0.01 -0.165 -0.7515 3063471 Maybridge4_001063 CN(/N=C/c1ncc(cc1Cl)C(F)(F)F)C(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A08 compound treatment 1.5521625E8 -2.2E7 -0.28 1.570137E8 -1.71E7 -0.29 -0.4021 -0.9996 3179583 Maybridge4_001064 COC(=O)c1ccc(n1C)S(=O)(=O)NCCNc2cccc(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A09 compound treatment 1.61740693E8 -1.55E7 -0.19 1.56694807E8 -1.74E7 -0.3 -0.3481 -0.9786 3063472 Maybridge4_001065 Cc1cccc(c1)n2c(CC#N)n[nH]c2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A10 compound treatment 1.51759635E8 -2.55E7 -0.32 1.50645322E8 -2.35E7 -0.4 -0.5098 -0.9936 1646442 Maybridge4_001066 Cc1ccc2N(CC(=O)N(C3CCCCC3)c4ccccc4)CCCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A11 compound treatment 1.57175194E8 -2.01E7 -0.25 1.72762555E8 -1330000.0 -0.02 -0.1941 -0.7681 1595838 Maybridge4_001067 COC(=O)c1sccc1S(=O)(=O)Nc2cc(OC)c(OC)cc2C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A12 compound treatment 1.64145227E8 -1.31E7 -0.16 1.67087799E8 -7010000.0 -0.12 -0.2009 -0.9881 3179584 Maybridge4_001068 FC(F)(F)c1ccc(N2CCc3ccccc3C2)c(NC(=O)c4ccccc4)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A13 compound treatment 1.52419161E8 -2.48E7 -0.31 1.51392242E8 -2.27E7 -0.39 -0.4949 -0.9939 3063473 Maybridge4_001069 FC(F)(F)C1=NCCN(C=C1)S(=O)(=O)c2ccc(CNC(=O)c3ccccc3)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A14 compound treatment 1.63811087E8 -1.34E7 -0.17 1.57638558E8 -1.65E7 -0.28 -0.3183 -0.9697 1536339 Maybridge4_001070 OC(=O)COCC(=O)N1CCCN(CC1)c2nc3ccc(Cl)cc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A15 compound treatment 1.20850256E8 -5.64E7 -0.71 1.5729161E8 -1.68E7 -0.29 -0.7036 -0.9214 1391994 Maybridge4_001071 CCOC(=O)C1CCN(CC1)c2ncnc3cc(OC)c(OC)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A16 compound treatment 1.73851719E8 -3380000.0 -0.04 1.59844131E8 -1.43E7 -0.24 -0.2025 -0.8178 1501197 Maybridge4_001072 Cc1nc(cs1)c2ccc(s2)S(=O)(=O)NCC3CCN(CC3)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A17 compound treatment 1.72290734E8 -4940000.0 -0.06 1.920426E8 1.79E7 0.31 0.1734 0.5532 1440783 Maybridge4_001073 COc1cc(cc(OC)c1OC)C(CC(=O)O)CC(=O)N2CCC(CC2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A18 compound treatment 1.81525681E8 4290000.0 0.05 1.82986051E8 8890000.0 0.15 0.1457 0.9025 1175173 Maybridge4_001074 CC(C)(C)c1ccc(cc1)c2noc(n2)c3ccc4OCCc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A19 compound treatment 1.73359517E8 -3870000.0 -0.05 1.84709241E8 1.06E7 0.18 0.0941 0.5003 1213784 Maybridge4_001075 NC(=O)C1CCN(CN2C(=O)c3ccccc3C2=O)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A20 compound treatment 1.67215329E8 -1.0E7 -0.13 1.64441063E8 -9660000.0 -0.17 -0.2058 -0.9909 1134687 Maybridge4_001076 OC(=O)c1nccnc1C(=O)Nc2ccc(cc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A21 compound treatment 1.09443138E8 -6.78E7 -0.85 1.77581495E8 3480000.0 0.06 -0.5592 -0.6559 3063474 Maybridge4_001077 FC(F)(F)c1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A22 compound treatment 1.75106395E8 -2130000.0 -0.03 1.18688275E8 -5.54E7 -0.95 -0.6896 -0.7267 3179585 Maybridge4_001078 COc1ccccc1N2CCN(CC2)C(=O)c3cnn(c3C)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A23 mock treatment 1.59208664E8 -1.8E7 -0.23 1.68121053E8 -5980000.0 -0.1 -0.2322 -0.9357 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 A24 mock treatment 1.56753935E8 -2.05E7 -0.26 1.65542182E8 -8560000.0 -0.15 -0.2852 -0.9645 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B01 compound treatment 1.06047832E8 -7.12E7 -0.89 1.76022101E8 1920000.0 0.03 -0.6081 -0.6806 1733246 Maybridge4_001079 Cc1cnc(cn1)C(=O)Nc2nnn[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B02 compound treatment 1.56274233E8 -2.1E7 -0.26 9.6987856E7 -7.71E7 -1.32 -1.1193 -0.8316 1403239 Maybridge4_001080 NC(=O)C1CCN(CC(O)COc2ccc(cc2)c3csnn3)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B03 compound treatment 9.9041148E7 -7.82E7 -0.98 1.03501554E8 -7.06E7 -1.21 -1.5481 -0.9946 1480432 Maybridge4_001081 COc1ccc(cc1OC)S(=O)(=O)NCCN2CCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B04 compound treatment 9.9197825E7 -7.8E7 -0.98 1.58618374E8 -1.55E7 -0.26 -0.8796 -0.8673 3179682 Maybridge4_001082 Cc1ccsc1CNC(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B05 compound treatment 1.54854487E8 -2.24E7 -0.28 1.07570093E8 -6.65E7 -1.14 -1.0038 -0.8558 1539091 Maybridge4_001083 OC(=O)c1cc(ccc1O)S(=O)(=O)NCCN2CCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B06 compound treatment 1.54478958E8 -2.28E7 -0.29 1.03099113E8 -7.1E7 -1.22 -1.0612 -0.8501 1590468 Maybridge4_001084 O=C(Nc1ccc(cc1)S(=O)(=O)N2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B07 compound treatment 1.58670781E8 -1.86E7 -0.23 1.65375439E8 -8720000.0 -0.15 -0.2702 -0.9769 1660094 Maybridge4_001085 Cc1nn(nc1C(=O)NC2CCS(=O)(=O)C2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B08 compound treatment 1.52211036E8 -2.5E7 -0.31 1.54052656E8 -2.0E7 -0.34 -0.4646 -0.999 1742612 Maybridge4_001086 COc1ccc(SCC(=O)NCc2ccc3OCOc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B09 compound treatment 1.51036307E8 -2.62E7 -0.33 1.47252215E8 -2.68E7 -0.46 -0.5573 -0.9865 3179683 Maybridge4_001087 CCOC(=O)c1c(NC(=O)NC(C)(C)C)sc2CN(C)CCc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B10 compound treatment 1.5714335E8 -2.01E7 -0.25 1.68257352E8 -5840000.0 -0.1 -0.2489 -0.918 1477333 Maybridge4_001088 Cc1cc(NC(=O)C2CCN(CC2)C(=O)OCc3ccccc3)n(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B11 compound treatment 1.53645699E8 -2.36E7 -0.3 1.55438212E8 -1.87E7 -0.32 -0.4351 -0.9993 1603040 Maybridge4_001089 O=C(N1CCN(CC1)C(c2ccccc2)c3ccccc3)c4ccc5OCCc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B12 compound treatment 9.5059928E7 -8.22E7 -1.03 1.40506207E8 -3.36E7 -0.58 -1.1355 -0.962 3179684 Maybridge4_001090 Cn1c(SCC(=O)c2ccc3OCCOc3c2)nnc1c4ccc5ccccc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B13 compound treatment 1.5164673E8 -2.56E7 -0.32 1.63371818E8 -1.07E7 -0.18 -0.3568 -0.9649 3063475 Maybridge4_001091 CN(C(=O)c1scc(c1C)S(=O)(=O)c2ccc(Cl)cc2)c3nnc(s3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B14 compound treatment 1.32389458E8 -4.48E7 -0.56 1.41290813E8 -3.28E7 -0.56 -0.7949 -1.0 3179685 Maybridge4_001092 CCOC(=O)c1c(C)n(c(C)c1/C=C/2\C(=O)Nc3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B15 compound treatment 1.63259733E8 -1.4E7 -0.18 1.97933249E8 2.38E7 0.41 0.1646 0.3705 1321807 Maybridge4_001093 Cn1nc(cc1C(=O)NN2CCOCC2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B16 compound treatment 1.40583536E8 -3.67E7 -0.46 1.00554047E8 -7.35E7 -1.26 -1.2153 -0.9068 3179686 Maybridge4_001094 Cc1ccc(cc1)S(=O)(=O)CCSc2nccc(n2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B17 compound treatment 9.6609402E7 -8.06E7 -1.01 1.12181031E8 -6.19E7 -1.06 -1.4646 -0.9997 1191907 Maybridge4_001095 O=C1NCCN1CCNC(=S)NC2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B18 compound treatment 1.50248423E8 -2.7E7 -0.34 1.00299963E8 -7.38E7 -1.26 -1.1326 -0.866 1709557 Maybridge4_001096 COc1ccc(OCC(O)CNC(=O)c2c(C)onc2c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B19 compound treatment 1.5238134E8 -2.49E7 -0.31 1.48768363E8 -2.53E7 -0.43 -0.527 -0.9869 1259000 Maybridge4_001097 CCCc1c(cnn1c2ccccc2)C(=O)N(Cc3cccs3)Cc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B20 compound treatment 1.55958773E8 -2.13E7 -0.27 1.55161207E8 -1.89E7 -0.32 -0.4179 -0.9953 1607244 Maybridge4_001098 O=C(N1CCN(CCN2CCOCC2)CC1)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B21 compound treatment 1.71118008E8 -6120000.0 -0.08 1.69801245E8 -4300000.0 -0.07 -0.1063 -0.9998 1594969 Maybridge4_001099 CCCc1c(cnn1c2ccccc2)C(=O)Nc3nc[nH]n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B22 compound treatment 1.60739191E8 -1.65E7 -0.21 1.86505025E8 1.24E7 0.21 0.0039 0.013 3063476 Maybridge4_001100 Clc1ccc(Sc2cccc(Cl)c2Cn3cccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B23 mock treatment 1.70038357E8 -7200000.0 -0.09 1.65534841E8 -8560000.0 -0.15 -0.1675 -0.9729 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 B24 mock treatment 9.7475726E7 -7.98E7 -1.0 1.49325466E8 -2.48E7 -0.42 -1.0073 -0.927 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C01 compound treatment 1.47896628E8 -2.93E7 -0.37 1.31374765E8 -4.27E7 -0.73 -0.7774 -0.9495 3179687 Maybridge4_001101 Cc1cc(NS(=O)(=O)c2ccc(cc2)N3C(=O)C=CC3=O)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C02 compound treatment 1.65344383E8 -1.19E7 -0.15 1.41264399E8 -3.28E7 -0.56 -0.5029 -0.8648 1404378 Maybridge4_001102 OC1(CCN(CC1)C(=O)CC2(CC3CC4CC(C3)C2)C4)c5ccc(Cl)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C03 compound treatment 1.61673863E8 -1.56E7 -0.2 1.39007712E8 -3.51E7 -0.6 -0.5628 -0.891 1249628 Maybridge4_001103 COc1ccc(cc1OC)C(=O)N2CCN(CC2)c3ncnc4cc(sc34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C04 compound treatment 1.71929507E8 -5300000.0 -0.07 1.68723792E8 -5370000.0 -0.09 -0.1121 -0.9874 3063496 Maybridge4_001104 Fc1ccc(NC(=O)NCc2nc(no2)c3ccc(cc3)C(F)(F)F)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C05 compound treatment 1.77211273E8 -23200.0 0.0 1.80023332E8 5930000.0 0.1 0.0715 0.7051 3063497 Maybridge4_001105 OC(CSc1ccccc1NC(=O)/C=C\C(=O)O)Cn2ccc(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C06 compound treatment 1.75423545E8 -1810000.0 -0.02 1.72245351E8 -1850000.0 -0.03 -0.0385 -0.9866 3063498 Maybridge4_001106 Cn1nc(c(c1NC(=O)c2nccnc2C(=O)O)c3cccc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C07 compound treatment 1.78969235E8 1730000.0 0.02 1.74680515E8 583000.0 0.01 0.0224 0.9376 3179688 Maybridge4_001107 CN(/N=C/c1ncc(cc1Cl)C(F)(F)F)C(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C08 compound treatment 1.62197048E8 -1.5E7 -0.19 1.45568367E8 -2.85E7 -0.49 -0.4787 -0.9144 3063499 Maybridge4_001108 FC(F)(F)C1=NCCN(C=C1)C(=O)C2CCN(CC2)c3nccc(n3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C09 compound treatment 1.60699263E8 -1.65E7 -0.21 1.61531682E8 -1.26E7 -0.22 -0.2988 -0.9998 1483010 Maybridge4_001109 COc1ccc(CN(Cc2cccn2C)C(=O)c3cc4cc(OC)ccc4[nH]3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C10 compound treatment 1.70342211E8 -6890000.0 -0.09 1.54844165E8 -1.93E7 -0.33 -0.2942 -0.8634 1408441 Maybridge4_001110 COC(=O)c1sc(cc1NC(=O)COCC(=O)O)c2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C11 compound treatment 1.77863542E8 629000.0 0.01 1.67083692E8 -7010000.0 -0.12 -0.0793 -0.6592 3179689 Maybridge4_001111 FC(F)(F)c1cc(N2CCN(CC2)C(=O)C3CCC3)c4ccccc4n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C12 compound treatment 1.89644036E8 1.24E7 0.16 1.85069988E8 1.1E7 0.19 0.2429 0.9956 3063500 Maybridge4_001112 FC(F)(F)c1oc(cc1C(=O)NCc2cccs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C13 compound treatment 1.82429246E8 5190000.0 0.07 2.07111493E8 3.3E7 0.57 0.4457 0.7835 3179690 Maybridge4_001113 CCC(=O)N(C)c1nc(cs1)c2ccc(Cl)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C14 compound treatment 1.93981604E8 1.67E7 0.21 1.79895451E8 5800000.0 0.1 0.2187 0.9414 3179691 Maybridge4_001114 Fc1ccc(cc1)S(=O)(=O)Nc2ccccc2NC3CCN(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C15 compound treatment 1.92715801E8 1.55E7 0.19 1.78067765E8 3970000.0 0.07 0.1854 0.901 1317474 Maybridge4_001115 COc1cccc(Cl)c1NC(=O)N2CCN(CC2)c3cc(C)nc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C16 compound treatment 1.99279565E8 2.2E7 0.28 1.8402699E8 9930000.0 0.17 0.3157 0.9727 3179692 Maybridge4_001116 CC(C)(C)OC(=O)N1CCC(CNS(=O)(=O)c2cccc(c2)C(F)(F)F)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C17 compound treatment 1.81409779E8 4180000.0 0.05 1.96284272E8 2.22E7 0.38 0.3056 0.7971 1139184 Maybridge4_001117 COc1ccc(CC2CCC3(CC2)NC(=O)c4ccccc4O3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C18 compound treatment 1.79809663E8 2580000.0 0.03 1.84318326E8 1.02E7 0.17 0.1466 0.8237 1486833 Maybridge4_001118 COC(=O)c1cc(oc1C)S(=O)(=O)NCC2CN(Cc3ccccc3)CN(Cc4ccccc4)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C19 compound treatment 1.87037473E8 9800000.0 0.12 1.931583E8 1.91E7 0.33 0.3177 0.911 1538683 Maybridge4_001119 OC1(CCN(CN2C(=O)c3ccccc3C2=O)CC1)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C20 compound treatment 1.94149698E8 1.69E7 0.21 1.87488542E8 1.34E7 0.23 0.3121 0.9993 3063501 Maybridge4_001120 OC(=O)/C=C/C(=O)Nc1ccc(nc1N2CCOCC2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C21 compound treatment 1.96337717E8 1.91E7 0.24 1.83517669E8 9420000.0 0.16 0.2835 0.9814 1658419 Maybridge4_001121 NC(=O)C1CCN(CC(O)CSc2ccc(F)cc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C22 compound treatment 2.02035044E8 2.48E7 0.31 1.89779246E8 1.57E7 0.27 0.4098 0.9973 1233858 Maybridge4_001122 CS(=O)(=O)CS(=O)(=O)Nc1ccc2OCCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C23 mock treatment 1.89900377E8 1.27E7 0.16 1.88289683E8 1.42E7 0.24 0.2841 0.9788 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 C24 mock treatment 1.87221823E8 9990000.0 0.13 1.82597635E8 8500000.0 0.15 0.1915 0.9972 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D01 compound treatment 1.89105296E8 1.19E7 0.15 1.78061525E8 3960000.0 0.07 0.1533 0.9367 1662148 Maybridge4_001123 Cc1nc(cn1C)S(=O)(=O)NC2CCS(=O)(=O)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D02 compound treatment 1.81701972E8 4470000.0 0.06 1.76435593E8 2340000.0 0.04 0.0679 0.9864 1341736 Maybridge4_001124 CCN(CC)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D03 compound treatment 1.75108473E8 -2130000.0 -0.03 1.70776285E8 -3320000.0 -0.06 -0.0591 -0.9405 3063502 Maybridge4_001125 Cn1cnc(c1)S(=O)(=O)NCC2CCN(CC2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D04 compound treatment 1.75683639E8 -1550000.0 -0.02 1.65302655E8 -8790000.0 -0.15 -0.1202 -0.7919 3179693 Maybridge4_001126 Cc1nnc(Sc2nc3ccc(Cl)cc3s2)n1c4ccc5OCCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D05 compound treatment 1.75373616E8 -1860000.0 -0.02 1.79895057E8 5800000.0 0.1 0.0537 0.5264 1259497 Maybridge4_001127 O=C1NCCN1CCNS(=O)(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D06 compound treatment 1.8200835E8 4770000.0 0.06 1.78498492E8 4400000.0 0.08 0.0956 0.9935 1281709 Maybridge4_001128 OC(=O)CSCC(=O)N1CCN(Cc2ccc3OCOc3c2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D07 compound treatment 1.7318296E8 -4050000.0 -0.05 1.81388156E8 7290000.0 0.12 0.0523 0.3882 1146339 Maybridge4_001129 CCCCc1ccc(cc1)n2c(coc2=O)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D08 compound treatment 1.68002264E8 -9230000.0 -0.12 1.82409486E8 8310000.0 0.14 0.0187 0.102 1522891 Maybridge4_001130 COC(=O)C1=C(CSC1)Nc2ccccc2NS(=O)(=O)c3cn(C)cn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D09 compound treatment 2.2900745E8 5.18E7 0.65 2.39901242E8 6.58E7 1.13 1.2557 0.9658 3063503 Maybridge4_001131 FC(F)(F)c1nn2c(=O)cc([nH]c2c1c3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D10 compound treatment 1.90848036E8 1.36E7 0.17 1.91934927E8 1.78E7 0.31 0.3367 0.9623 1088065 Maybridge4_001132 Cc1cc(C(=O)Nc2ccccc2)c(C)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D11 compound treatment 1.76451729E8 -783000.0 -0.01 1.76649548E8 2550000.0 0.04 0.024 0.5348 1383227 Maybridge4_001133 O=C(OCCn1ncc2ccccc2c1=O)c3ccc4OCCc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D12 compound treatment 1.72414352E8 -4820000.0 -0.06 1.7010529E8 -3990000.0 -0.07 -0.0911 -0.9981 1524796 Maybridge4_001134 Cc1ccc(cc1)c2cc(Cc3ccccc3)c(=O)[nH]n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D13 compound treatment 1.67738477E8 -9500000.0 -0.12 1.61552069E8 -1.25E7 -0.21 -0.2361 -0.9613 1531019 Maybridge4_001135 Cc1c(csc1C(=O)N(Cc2ccccc2)Cc3cccnc3)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D14 compound treatment 1.74157322E8 -3080000.0 -0.04 1.68151075E8 -5950000.0 -0.1 -0.0993 -0.9119 3063504 Maybridge4_001136 OC(=O)c1nccnc1C(=O)Nc2ccc(CC#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D15 compound treatment 1.82740028E8 5510000.0 0.07 1.83167292E8 9070000.0 0.16 0.1586 0.9335 1469748 Maybridge4_001137 CSc1nsc(SC)c1C(=O)NN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D16 compound treatment 1.79299592E8 2070000.0 0.03 1.83030128E8 8930000.0 0.15 0.1264 0.8153 3063505 Maybridge4_001138 Fc1ccc(cc1)S(=O)(=O)CCSc2nccc(n2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D17 compound treatment 1.82120719E8 4890000.0 0.06 1.90798848E8 1.67E7 0.29 0.2455 0.8396 3179791 Maybridge4_001139 COC(=O)c1ccc(n1C)S(=O)(=O)Nc2ccc3COC(=O)c3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D18 compound treatment 1.84553628E8 7320000.0 0.09 1.91812262E8 1.77E7 0.3 0.2793 0.8817 3179792 Maybridge4_001140 COc1ccc(OCC(O)CNC(=O)c2ccc(OC(F)(F)F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D19 compound treatment 1.8011508E8 2880000.0 0.04 1.5904828E8 -1.5E7 -0.26 -0.1566 -0.602 1658181 Maybridge4_001141 CCCc1c(cnn1c2ccccc2)C(=O)NCc3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D20 compound treatment 1.85057689E8 7820000.0 0.1 1.84838745E8 1.07E7 0.18 0.1994 0.9568 1302806 Maybridge4_001142 CCOC(=O)N1CCC(CC1)NC(=O)Nc2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D21 compound treatment 1.89845603E8 1.26E7 0.16 1.85288715E8 1.12E7 0.19 0.2473 0.9955 1417198 Maybridge4_001143 COc1cccc2n(C)nc(NC(=O)CCC(=O)O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D22 compound treatment 1.92287984E8 1.51E7 0.19 1.95678787E8 2.16E7 0.37 0.3948 0.9515 1130087 Maybridge4_001144 COc1ccc(OCC(O)CNC(=O)Nc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D23 mock treatment 1.90747239E8 1.35E7 0.17 1.76414423E8 2320000.0 0.04 0.1479 0.8496 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 D24 mock treatment 1.83626418E8 6390000.0 0.08 1.79314322E8 5220000.0 0.09 0.1198 0.9986 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E01 compound treatment 1.46586663E8 -3.06E7 -0.38 1.36771212E8 -3.73E7 -0.64 -0.7237 -0.9704 1356815 Maybridge4_001145 Cn1ncc2c(NN3C(=O)CCC3=O)ncnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E02 compound treatment 2.43954425E8 6.67E7 0.84 2.56625553E8 8.25E7 1.41 1.5908 0.9688 3063506 Maybridge4_001146 FC(F)(F)c1ccc(NC(=O)Nc2ccc(cc2)N3CCN(Cc4ccccc4)CC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E03 compound treatment 2.3906686E8 6.18E7 0.78 2.55460942E8 8.14E7 1.39 1.5333 0.9618 3179793 Maybridge4_001147 COC(=O)c1sc(cc1NS(=O)(=O)c2ccc(C)cc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E04 compound treatment 2.12482638E8 3.52E7 0.44 1.02032125E8 -7.21E7 -1.23 -0.5596 -0.427 1593578 Maybridge4_001148 Cc1noc(C)c1n2sc(=O)n(CC3CC3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E05 compound treatment 2.50808127E8 7.36E7 0.92 2.42007781E8 6.79E7 1.16 1.4746 0.9935 1366685 Maybridge4_001149 OC(CSc1ccccc1NC(=O)c2ccc(Cl)cc2)Cn3ccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E06 compound treatment 2.36853643E8 5.96E7 0.75 2.34544036E8 6.04E7 1.03 1.2605 0.9873 1718437 Maybridge4_001150 CCCCc1ccc(NC(=O)N2CCN(CC2)c3cc(C)nc4ccccc34)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E07 compound treatment 2.47887634E8 7.07E7 0.89 2.44317897E8 7.02E7 1.2 1.4767 0.9888 3063507 Maybridge4_001151 CNC(=S)NC1CC2CCC1C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E08 compound treatment 1.89854189E8 1.26E7 0.16 1.83712511E8 9620000.0 0.16 0.2283 0.9998 1663721 Maybridge4_001152 Fc1ccc(cc1Cl)n2sc(=O)n(C3Cc4ccccc4C3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E09 compound treatment 2.43501759E8 6.63E7 0.83 1.81533904E8 7440000.0 0.13 0.6778 0.806 3063508 Maybridge4_001153 Cc1nnsc1c2nc(cs2)c3ccc(Cl)s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E10 compound treatment 2.41139362E8 6.39E7 0.8 2.51589306E8 7.75E7 1.33 1.5048 0.9709 1128288 Maybridge4_001154 COC(=O)c1ccc(n1C)S(=O)(=O)N(Cc2ccccc2)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E11 compound treatment 2.52877703E8 7.56E7 0.95 2.35038112E8 6.09E7 1.04 1.4086 0.9989 1703913 Maybridge4_001155 CC(C)Cc1ccc(cc1)C(C)C(=O)Nc2cccc(c2)c3cnco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E12 compound treatment 1.9895189E8 2.17E7 0.27 1.18648449E8 -5.54E7 -0.95 -0.4785 -0.4846 1704448 Maybridge4_001156 Cc1cccc(Cl)c1n2sc(=O)n(CC3CC3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E13 compound treatment 2.43348271E8 6.61E7 0.83 2.62665996E8 8.86E7 1.52 1.6585 0.9597 1205718 Maybridge4_001157 CN(C(=O)C1CCCCC1)c2nc(cs2)c3ccc(Cl)s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E14 compound treatment 2.11737581E8 3.45E7 0.43 2.97840065E8 1.24E8 2.12 1.8039 0.8344 3179794 Maybridge4_001158 Cc1ccc(OCC(O)CNc2ccc(Br)c(c2)C(F)(F)F)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E15 compound treatment 2.52155073E8 7.49E7 0.94 2.54390151E8 8.03E7 1.37 1.6365 0.9828 3063509 Maybridge4_001159 OC(=O)c1sccc1S(=O)(=O)N2CCN(CC2)c3ccc(cn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E16 compound treatment 2.54119328E8 7.69E7 0.96 2.65086701E8 9.1E7 1.56 1.7833 0.9734 1390204 Maybridge4_001160 Cn1cnc(c1)S(=O)(=O)NCC2CCN(CC2)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E17 compound treatment 2.52080629E8 7.48E7 0.94 2.55253915E8 8.12E7 1.39 1.6462 0.9818 1537127 Maybridge4_001161 COc1ccccc1NC(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E18 compound treatment 2.58343768E8 8.11E7 1.02 2.58858919E8 8.48E7 1.45 1.7454 0.9849 1388804 Maybridge4_001162 COc1ccc(cc1)C(=O)CN2CCCc3cc(C)ccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E19 compound treatment 2.52601242E8 7.54E7 0.95 2.52674812E8 7.86E7 1.35 1.6196 0.9851 1307254 Maybridge4_001163 COc1ccc(CN(Cc2cccn2C)S(=O)(=O)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E20 compound treatment 2.54752694E8 7.75E7 0.97 2.59899149E8 8.58E7 1.47 1.7262 0.98 1235221 Maybridge4_001164 Fc1cccc(Cl)c1CN2CCC(CC2)NS(=O)(=O)c3cccc4nonc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E21 compound treatment 2.60878467E8 8.36E7 1.05 2.44819136E8 7.07E7 1.21 1.598 0.9975 3179795 Maybridge4_001165 COC(=O)c1ccc(n1C)S(=O)(=O)N2CCN(CC2)c3ccc(cn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E22 compound treatment 2.9610663E8 1.19E8 1.49 1.99935437E8 2.58E7 0.44 1.3672 0.879 1482186 Maybridge4_001166 Cc1ccc(cc1)S(=O)(=O)NC(=O)NCC2CCN(CC2)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E23 mock treatment 2.56052307E8 7.88E7 0.99 2.70537969E8 9.64E7 1.65 1.8665 0.9699 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 E24 mock treatment 2.31671E8 5.44E7 0.68 2.46151889E8 7.21E7 1.23 1.355 0.9611 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F01 compound treatment 2.41397514E8 6.42E7 0.8 2.2906892E8 5.5E7 0.94 1.2345 0.997 3063510 Maybridge4_001167 Fc1cccc(Cl)c1CN2CCC(CC2)NS(=O)(=O)c3ccc(cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F02 compound treatment 2.07881113E8 3.06E7 0.38 2.56915631E8 8.28E7 1.42 1.2743 0.8675 1623040 Maybridge4_001168 CCN(CC)c1ccc(NC(=O)Nc2ccc(OCc3ccccc3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F03 compound treatment 1.94070215E8 1.68E7 0.21 2.42929163E8 6.88E7 1.18 0.9825 0.8208 1283930 Maybridge4_001169 C1C(Cc2ccccc12)Nc3nc(ns3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F04 compound treatment 2.84265239E8 1.07E8 1.34 2.63613296E8 8.95E7 1.53 2.0329 0.9978 3179796 Maybridge4_001170 CC(C)(CC(=O)O)CC(=O)Nc1ccc(cc1)n2nc(cc2c3cccs3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F05 compound treatment 2.71595508E8 9.44E7 1.18 2.79170277E8 1.05E8 1.8 2.1088 0.9794 3063512 Maybridge4_001171 FC(F)(F)c1cc(cc(c1)S(=O)(=O)NCCN2CCNC2=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F06 compound treatment 2.8259781E8 1.05E8 1.32 2.8299627E8 1.09E8 1.86 2.2527 0.9858 1430388 Maybridge4_001172 Cc1ccc(NC(=O)c2ccsc2)cc1NS(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F07 compound treatment 1.56076876E8 -2.12E7 -0.27 2.85062831E8 1.11E8 1.9 1.1555 0.6025 1313330 Maybridge4_001173 Cc1oc(cc1C(=O)NCc2ccc3OCOc3c2)S(=O)(=O)N4CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F08 compound treatment 2.42067534E8 6.48E7 0.81 2.72151068E8 9.81E7 1.68 1.762 0.9447 3063513 Maybridge4_001174 COC(=O)C1=C(CSC1)Nc2ccccc2NS(=O)(=O)c3ccc(cc3Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F09 compound treatment 2.72491602E8 9.53E7 1.19 3.12205085E8 1.38E8 2.36 2.5166 0.9501 1684282 Maybridge4_001175 COC(=O)c1sccc1c2ccc(CN3CCC(CC3)c4ccccc4OC)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F10 compound treatment 2.24255849E8 4.7E7 0.59 2.13534421E8 3.94E7 0.68 0.8945 0.9977 1364415 Maybridge4_001176 Cc1oc(cc1C(=O)NC2Cc3ccccc3C2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F11 compound treatment 2.5855919E8 8.13E7 1.02 2.63912952E8 8.98E7 1.54 1.8085 0.9802 3063529 Maybridge4_001177 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2ccc(COC(=O)c3ccc4OCCc4c3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F12 compound treatment 1.62499809E8 -1.47E7 -0.18 1.89588891E8 1.55E7 0.27 0.0568 0.1758 1341364 Maybridge4_001178 Cc1ccc2nc(sc2c1)c3ccc(NC(=O)C4CCC4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F13 compound treatment 2.80132247E8 1.03E8 1.29 3.08959913E8 1.35E8 2.31 2.5451 0.9623 3063530 Maybridge4_001179 O=C(NCCN1CCN(Cc2ccccc2)CC1)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F14 compound treatment 1.94169578E8 1.69E7 0.21 2.86211624E8 1.12E8 1.92 1.5073 0.7806 1693889 Maybridge4_001180 O=C(Nc1ccccc1)Nc2ccc(CC#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F15 compound treatment 2.81352716E8 1.04E8 1.31 2.7357797E8 9.95E7 1.7 2.1277 0.9914 3063531 Maybridge4_001181 Cc1nc(ccc1C(=O)NN2CCOCC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F16 compound treatment 2.28897157E8 5.17E7 0.65 2.72491887E8 9.84E7 1.68 1.6493 0.9139 1169808 Maybridge4_001182 O=C(Nc1cccc2ccccc12)N3CCN(CC3)c4ncccc4C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F17 compound treatment 1.98237411E8 2.1E7 0.26 2.88562565E8 1.14E8 1.96 1.5718 0.795 3179797 Maybridge4_001183 Cc1onc(c1C(=O)N(C(=O)c2c(C)onc2c3ccccc3)c4ncc(C)nc4C)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F18 compound treatment 1.75644734E8 -1590000.0 -0.02 2.66905261E8 9.28E7 1.59 1.1093 0.6982 1265508 Maybridge4_001184 COc1ccc(OCC(O)CNC(=O)c2sccc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F19 compound treatment 2.35898145E8 5.87E7 0.74 2.4567561E8 7.16E7 1.23 1.3868 0.9703 3063532 Maybridge4_001185 COC(=O)c1cnc(nc1C(F)(F)F)N2CCCN(CC2)C(=O)c3cc(nn3C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F20 compound treatment 2.66985648E8 8.98E7 1.13 2.8534069E8 1.11E8 1.9 2.1426 0.9686 3179798 Maybridge4_001186 CCOC(=O)N1CCC(CC1)NC(=O)Nc2cc(C)oc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F21 compound treatment 2.63295035E8 8.61E7 1.08 2.78478883E8 1.04E8 1.79 2.0268 0.9709 1597233 Maybridge4_001187 COc1cccc2n(C)nc(NC(=O)CSCC(=O)O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F22 compound treatment 2.47083097E8 6.98E7 0.88 2.57563507E8 8.35E7 1.43 1.6299 0.9724 1439715 Maybridge4_001188 CCc1ccc(cc1)S(=O)(=O)NCC(O)COc2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F23 mock treatment 2.55478118E8 7.82E7 0.98 2.48223438E8 7.41E7 1.27 1.5913 0.9919 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 F24 mock treatment 2.31274301E8 5.4E7 0.68 2.36773252E8 6.27E7 1.07 1.238 0.9755 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G01 compound treatment 1.96917969E8 1.97E7 0.25 1.98480796E8 2.44E7 0.42 0.4697 0.9686 1075387 Maybridge4_001189 NC(=O)NC1CCCCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G02 compound treatment 2.23174802E8 4.59E7 0.58 2.15751685E8 4.17E7 0.71 0.9117 0.9944 1679776 Maybridge4_001190 COC(=O)c1c(C)oc(C)c1S(=O)(=O)NC2CCCCCCCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G03 compound treatment 2.07007644E8 2.98E7 0.37 2.15836192E8 4.17E7 0.71 0.7693 0.9542 3063533 Maybridge4_001191 COC(=O)c1cnc(nc1C(F)(F)F)n2ncc(C#N)c2N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G04 compound treatment 2.35889821E8 5.87E7 0.74 2.16271534E8 4.22E7 0.72 1.0308 1.0 1394712 Maybridge4_001192 OCCN1CCN(CC1)C2=Cc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G05 compound treatment 2.44907554E8 6.77E7 0.85 2.3315198E8 5.91E7 1.01 1.3151 0.9962 1644505 Maybridge4_001193 CC(C)(C)NC(=O)N1CCN(CC1)c2nc(ns2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G06 compound treatment 2.3205054E8 5.48E7 0.69 2.24762796E8 5.07E7 0.87 1.0995 0.9934 3063534 Maybridge4_001194 OC(=O)COCC(=O)N1CCN(CC1)c2cc(nc3ccccc23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G07 compound treatment 2.45035813E8 6.78E7 0.85 2.40871668E8 6.68E7 1.14 1.4097 0.9894 1201054 Maybridge4_001195 COc1ccccc1NC(=S)NC2CC3CCC2C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G08 compound treatment 1.59716955E8 -1.75E7 -0.22 1.92475284E8 1.84E7 0.31 0.0671 0.1748 1231183 Maybridge4_001196 CCOC(=O)c1cccc(c1)n2sc(=O)n(C3Cc4ccccc4C3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G09 compound treatment 2.2943221E8 5.22E7 0.65 2.32753107E8 5.87E7 1.0 1.173 0.9785 1624776 Maybridge4_001197 Clc1ccc(s1)c2csc(n2)c3ccc4OCCc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G10 compound treatment 2.26616506E8 4.94E7 0.62 2.34472706E8 6.04E7 1.03 1.1688 0.97 1282547 Maybridge4_001198 COC(=O)c1ccc(n1C)S(=O)(=O)N(C2CCCCC2)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G11 compound treatment 2.4120959E8 6.4E7 0.8 2.31457198E8 5.74E7 0.98 1.2618 0.995 3063535 Maybridge4_001199 COC(=O)c1cc(oc1C)S(=O)(=O)Nc2cccc(c2)c3cnco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G12 compound treatment 1.88819169E8 1.16E7 0.15 1.42530237E8 -3.16E7 -0.54 -0.2793 -0.4992 3063536 Maybridge4_001200 FC(F)(F)c1ccccc1n2sc(=O)n(CC3CC3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G13 compound treatment 2.27904264E8 5.07E7 0.64 2.34125237E8 6.0E7 1.03 1.176 0.9733 3178224 Maybridge4_001201 COc1ccc(Oc2ccc(cc2NS(=O)(=O)c3cccc4nonc34)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G14 compound treatment 2.3791549E8 6.07E7 0.76 2.568062E8 8.27E7 1.42 1.5394 0.9576 3178225 Maybridge4_001202 FC(F)(F)c1cc(NC(=O)c2ccc(CN3C(=O)c4ccccc4C3=O)o2)ccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G15 compound treatment 2.45508504E8 6.83E7 0.86 2.35207708E8 6.11E7 1.05 1.3453 0.9951 3063537 Maybridge4_001203 OC(=O)c1sccc1S(=O)(=O)Nc2ccccc2N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G16 compound treatment 2.45111517E8 6.79E7 0.85 2.37808418E8 6.37E7 1.09 1.3733 0.9925 1305367 Maybridge4_001204 CC(C)(C)OC(=O)N1CCC(CNC(=O)Nc2ccccc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G17 compound treatment 2.35351929E8 5.81E7 0.73 2.14588508E8 4.05E7 0.69 1.0056 0.9997 1532622 Maybridge4_001205 Clc1ccc(cc1Cl)n2c(SCC(=O)N3CCOCC3)nc4ccccc4c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G18 compound treatment 2.62620941E8 8.54E7 1.07 2.36214246E8 6.21E7 1.06 1.5093 1.0 1304189 Maybridge4_001206 Fc1ccc(cc1)c2ccc(=O)n(CCC#N)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G19 compound treatment 2.60389477E8 8.32E7 1.04 2.40517769E8 6.64E7 1.14 1.5416 0.9991 1675293 Maybridge4_001207 Cn1nc(NC(=O)C2CCC2C(=O)O)c3c(F)cccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G20 compound treatment 2.49854821E8 7.26E7 0.91 2.39667661E8 6.56E7 1.12 1.4378 0.9946 1345399 Maybridge4_001208 COC(=O)c1sccc1NC(=O)c2cc(oc2C)S(=O)(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G21 compound treatment 2.5588088E8 7.86E7 0.99 2.57444468E8 8.33E7 1.43 1.7065 0.9838 1463889 Maybridge4_001209 Cc1ccc(C)n1c2nn(c3cccc(F)c23)S(=O)(=O)c4ccc(C)c5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G22 compound treatment 2.52213805E8 7.5E7 0.94 2.43366824E8 6.93E7 1.19 1.5035 0.9934 1398688 Maybridge4_001210 Cc1cc(NS(=O)(=O)c2ccc3OCCOc3c2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G23 mock treatment 2.31254101E8 5.4E7 0.68 2.43071751E8 6.9E7 1.18 1.3141 0.9653 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 G24 mock treatment 2.40191087E8 6.3E7 0.79 2.26830425E8 5.27E7 0.9 1.1967 0.9978 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H01 compound treatment 2.34691944E8 5.75E7 0.72 2.34175529E8 6.01E7 1.03 1.2369 0.9849 1708371 Maybridge4_001211 OC(=O)COCC(=O)NC1CCN(Cc2c(F)cccc2Cl)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H02 compound treatment 1.64963996E8 -1.23E7 -0.15 2.3506258E8 6.1E7 1.04 0.6291 0.5964 3063538 Maybridge4_001212 Clc1ccc2nc(Sc3ccccc3NS(=O)(=O)c4ccc(C#N)cc4)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H03 compound treatment 2.44929109E8 6.77E7 0.85 2.38980832E8 6.49E7 1.11 1.3858 0.9912 1419067 Maybridge4_001213 Cc1c(cnn1c2ccc(F)cc2)C(=O)N(Cc3ccccc3)Cc4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H04 compound treatment 2.43450358E8 6.62E7 0.83 2.39726606E8 6.56E7 1.12 1.3817 0.989 1711883 Maybridge4_001214 NS(=O)(=O)c1ccc(NC(=O)CC2(CC(=O)O)CCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H05 compound treatment 2.46886761E8 6.97E7 0.87 2.43766065E8 6.97E7 1.19 1.4611 0.9883 1352488 Maybridge4_001215 Clc1c(sc2ccccc12)C(=O)NCCN3CCNC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H06 compound treatment 2.26408596E8 4.92E7 0.62 2.26772958E8 5.27E7 0.9 1.0738 0.9829 3178226 Maybridge4_001216 FC(F)(F)c1cc(no1)c2cc(cs2)S(=O)(=O)Nc3ccc4OCCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H07 compound treatment 2.59391614E8 8.22E7 1.03 2.40021749E8 6.59E7 1.13 1.5267 0.999 1151414 Maybridge4_001217 COc1ccccc1OCC(O)CNCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H08 compound treatment 1.86864616E8 9630000.0 0.12 2.40430269E8 6.63E7 1.14 0.8883 0.7779 1595899 Maybridge4_001218 COC(=O)C1=C(CSC1)Nc2ccccc2NC(=O)c3ccccc3C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H09 compound treatment 2.54212888E8 7.7E7 0.97 2.39609852E8 6.55E7 1.12 1.4758 0.9972 3063539 Maybridge4_001219 CC(C)n1c(SCC(=O)Nc2ccccc2Cl)nc3cc(Cl)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H10 compound treatment 2.60347518E8 8.31E7 1.04 2.48349847E8 7.43E7 1.27 1.636 0.9952 3178227 Maybridge4_001220 Cc1nc(ccc1C(=O)Nc2ccccc2c3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H11 compound treatment 2.29880395E8 5.26E7 0.66 1.99706446E8 2.56E7 0.44 0.777 0.9802 1134518 Maybridge4_001221 CN(C(=O)c1ccc(Cl)cc1)c2ccc(Cl)cc2C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H12 compound treatment 2.33218275E8 5.6E7 0.7 2.39803892E8 6.57E7 1.12 1.2919 0.9743 1256492 Maybridge4_001222 CCCc1ccc(cc1)S(=O)(=O)Nc2ccc(C)c(NS(=O)(=O)C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H13 compound treatment 1.90345965E8 1.31E7 0.16 2.4410181E8 7.0E7 1.2 0.9637 0.7967 1621469 Maybridge4_001223 CCOC(=O)C1=C(NC(=O)NC1C)C(C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H14 compound treatment 2.38617123E8 6.14E7 0.77 2.31191213E8 5.71E7 0.98 1.2356 0.993 1158832 Maybridge4_001224 CCc1ccnc(NC(=O)Nc2ccccc2C(C)(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H15 compound treatment 2.45793503E8 6.86E7 0.86 2.39798477E8 6.57E7 1.12 1.4034 0.9912 3178228 Maybridge4_001225 O=S(=O)(NN1CCOCC1)c2cc(cs2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H16 compound treatment 1.8456211E8 7330000.0 0.09 2.39838288E8 6.57E7 1.13 0.8607 0.7623 1405785 Maybridge4_001226 Clc1cncc(Cl)c1N2CCCN(CC2)C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H17 compound treatment 2.71736077E8 9.45E7 1.19 2.27005803E8 5.29E7 0.91 1.4787 0.9912 3178229 Maybridge4_001227 Cn1c(Cc2ccsc2)nnc1Sc3nc4ccc(Cl)cc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H18 compound treatment 2.66807802E8 8.96E7 1.12 2.4129941E8 6.72E7 1.15 1.608 0.9999 1596031 Maybridge4_001228 COc1ccc(OCC(O)CNC(=O)c2ccc(cc2)N(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H19 compound treatment 2.50664363E8 7.34E7 0.92 2.46277213E8 7.22E7 1.24 1.525 0.9895 1496534 Maybridge4_001229 COC(=O)c1ccc(n1C)S(=O)(=O)NN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H20 compound treatment 2.46560742E8 6.93E7 0.87 2.57867786E8 8.38E7 1.43 1.6289 0.9713 1382593 Maybridge4_001230 CCOC(=O)N1CCC(CC1)NC(=O)Nc2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H21 compound treatment 2.55723612E8 7.85E7 0.98 2.5421818E8 8.01E7 1.37 1.666 0.9868 1574673 Maybridge4_001231 COc1cccc2n(C)nc(NC(=O)c3nccnc3C(=O)O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H22 compound treatment 2.43435331E8 6.62E7 0.83 2.31141772E8 5.7E7 0.98 1.2777 0.9968 1461069 Maybridge4_001232 CCOc1ccccc1NC(=O)N2CCCN(CC2)c3ncccc3C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H23 mock treatment 2.38901393E8 6.17E7 0.77 2.16006497E8 4.19E7 0.72 1.0543 0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 H24 mock treatment 2.28453111E8 5.12E7 0.64 2.20681295E8 4.66E7 0.8 1.0182 0.9943 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I01 compound treatment 8.5696234E7 -9.15E7 -1.15 5.4696797E7 -1.19E8 -2.04 -2.2572 -0.9628 1638533 Maybridge4_001233 CC(C)(C)c1ccc(cc1)c2cc(NS(=O)(=O)c3ccccc3)c(s2)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I02 compound treatment 8.8328941E7 -8.89E7 -1.12 1.05213462E8 -6.89E7 -1.18 -1.6224 -0.9996 3178230 Maybridge4_001234 COC(=O)c1c(C)oc(C)c1S(=O)(=O)NCc2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I03 compound treatment 7.7427965E7 -9.98E7 -1.25 8.3473424E7 -9.06E7 -1.55 -1.9822 -0.9943 1615822 Maybridge4_001235 CCC(CO)NC(=S)Nc1ccsc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I04 compound treatment 1.20464776E8 -5.68E7 -0.71 1.30559801E8 -4.35E7 -0.75 -1.0306 -0.9997 1181672 Maybridge4_001236 COc1ccc(cc1)n2nnnc2c3c[nH]c4ccc(Cl)cc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I05 compound treatment 1.67812442E8 -9420000.0 -0.12 1.59364934E8 -1.47E7 -0.25 -0.2619 -0.9404 3178231 Maybridge4_001237 OC(=O)/C=C\C(=O)N1CCN(CC1)c2nc(ns2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I06 compound treatment 1.76060567E8 -1170000.0 -0.01 1.43659109E8 -3.04E7 -0.52 -0.3788 -0.7268 1121093 Maybridge4_001238 COC(=O)c1ccc(n1C)S(=O)(=O)NC2CCN(Cc3ccccc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I07 compound treatment 1.74350379E8 -2880000.0 -0.04 1.70852836E8 -3240000.0 -0.06 -0.0649 -0.9784 3178232 Maybridge4_001239 CCCN(CCC)C(=S)NC1CC2CC1C=C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I08 compound treatment 1.72216001E8 -5020000.0 -0.06 1.3104816E8 -4.3E7 -0.74 -0.5656 -0.7647 1340809 Maybridge4_001240 OC1CCN(CC1)C(=O)c2cccc(CN3CCN(CC3)c4nc(ns4)c5ccccc5)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I09 compound treatment 1.75792166E8 -1440000.0 -0.02 1.60734374E8 -1.34E7 -0.23 -0.1745 -0.7607 1278544 Maybridge4_001241 CN1CCN(CC1)c2ccc(NS(=O)(=O)c3cccc4nonc34)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I10 compound treatment 1.78868296E8 1630000.0 0.02 1.87900671E8 1.38E7 0.24 0.1816 0.7656 1350689 Maybridge4_001242 COC(=O)c1ccc(n1C)S(=O)(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I11 compound treatment 1.46768694E8 -3.05E7 -0.38 1.352249E8 -3.89E7 -0.67 -0.7408 -0.9653 3178233 Maybridge4_001243 Cn1c(CSc2ccnc3cc(Cl)ccc23)nnc1SCC(=O)c4ccc(Cl)s4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I12 compound treatment 1.71681424E8 -5550000.0 -0.07 1.71561091E8 -2540000.0 -0.04 -0.08 -0.9741 3063555 Maybridge4_001244 O/C(=C\Sc1nc2CCCCc2c(c1C#N)C(F)(F)F)/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I13 compound treatment 1.71978372E8 -5260000.0 -0.07 1.70220577E8 -3880000.0 -0.07 -0.0935 -1.0 1516805 Maybridge4_001245 COC(=O)Cc1nc(NC(=O)C2CCC2C(=O)O)sc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I14 compound treatment 1.52905345E8 -2.43E7 -0.31 1.43734698E8 -3.04E7 -0.52 -0.5833 -0.9678 1616395 Maybridge4_001246 CC(C)(C)OC(=O)N1CCC(CNC(=O)c2ccc(F)cc2F)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I15 compound treatment 1.50315675E8 -2.69E7 -0.34 1.48165025E8 -2.59E7 -0.44 -0.5527 -0.9909 1670393 Maybridge4_001247 Cc1oc(cc1c2nc(no2)c3ccc(cc3)C(C)(C)C)S(=O)(=O)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I16 compound treatment 1.38995586E8 -3.82E7 -0.48 1.27392879E8 -4.67E7 -0.8 -0.9045 -0.9701 1316867 Maybridge4_001248 CC(C)(C)c1ccc(cc1)c2nnc(SCc3cccc(c3)C(=O)N)n2c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I17 compound treatment 1.54406508E8 -2.28E7 -0.29 1.61269679E8 -1.28E7 -0.22 -0.3578 -0.9914 1620610 Maybridge4_001249 OC(CNCc1ccc2OCOc2c1)COc3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I18 compound treatment 1.5212606E8 -2.51E7 -0.31 1.31561695E8 -4.25E7 -0.73 -0.7376 -0.9297 1465779 Maybridge4_001250 CC(=O)Nc1cccc(c1)n2nnc(SCC(=O)c3ccccc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I19 compound treatment 1.59584579E8 -1.76E7 -0.22 1.61525058E8 -1.26E7 -0.22 -0.3087 -0.9999 1598604 Maybridge4_001251 Cn1nc(NC(=O)CC(C)(C)CC(=O)O)c2c(F)cccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I20 compound treatment 1.49212771E8 -2.8E7 -0.35 1.59452251E8 -1.46E7 -0.25 -0.4258 -0.9863 1238878 Maybridge4_001252 Cc1oc(cc1C(=O)Nc2ccccc2)S(=O)(=O)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I21 compound treatment 1.40844703E8 -3.64E7 -0.46 1.45330558E8 -2.88E7 -0.49 -0.671 -0.9993 1457140 Maybridge4_001253 Cc1ccc(C)n1c2nn(c3cccc(F)c23)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I22 compound treatment 1.47054325E8 -3.02E7 -0.38 1.58444754E8 -1.57E7 -0.27 -0.4572 -0.9857 1519073 Maybridge4_001254 O=S(=O)(NCC1CCN(CC1)S(=O)(=O)c2ccccc2)c3cccc4nonc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I23 mock treatment 1.54846706E8 -2.24E7 -0.28 1.65472365E8 -8620000.0 -0.15 -0.303 -0.9549 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 I24 mock treatment 1.59566964E8 -1.77E7 -0.22 1.56557058E8 -1.75E7 -0.3 -0.369 -0.9888 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J01 compound treatment 1.52981289E8 -2.43E7 -0.3 1.5498959E8 -1.91E7 -0.33 -0.4464 -0.9993 1542762 Maybridge4_001255 OC(=O)c1nccnc1C(=O)NC2CCN(Cc3c(F)cccc3Cl)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J02 compound treatment 1.50205577E8 -2.7E7 -0.34 1.67652329E8 -6440000.0 -0.11 -0.3178 -0.8912 1359019 Maybridge4_001256 CCCc1cnc(nc1)N2CCN(CC2)C(=S)NC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J03 compound treatment 1.62658891E8 -1.46E7 -0.18 1.83048205E8 8950000.0 0.15 -0.0209 -0.0878 1448044 Maybridge4_001257 CC(C)n1c(SCC(=O)c2ccccc2)nc3cc(Cl)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J04 compound treatment 1.40009991E8 -3.72E7 -0.47 1.89519534E8 1.54E7 0.26 -0.1435 -0.2675 1537193 Maybridge4_001258 CCS(=O)(=O)c1ccc(O)c(NC(=O)CCCC(=O)O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J05 compound treatment 1.69561815E8 -7670000.0 -0.1 1.93523081E8 1.94E7 0.33 0.1671 0.4826 1258625 Maybridge4_001259 Cc1oc(cc1C(=O)NCCN2CCNC2=O)S(=O)(=O)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J06 compound treatment 1.56684835E8 -2.05E7 -0.26 1.66000894E8 -8100000.0 -0.14 -0.2803 -0.9576 1248986 Maybridge4_001260 Cc1ccc2n(CC(=O)c3ccccc3)c(=O)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J07 compound treatment 1.69099812E8 -8130000.0 -0.1 1.91360022E8 1.73E7 0.3 0.1368 0.4376 1612362 Maybridge4_001261 OC(=O)COCC(=O)Nc1ccc2COC(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J08 compound treatment 1.58366369E8 -1.89E7 -0.24 1.89006268E8 1.49E7 0.26 0.0131 0.0376 1623545 Maybridge4_001262 COC(=O)C1=C(CSC1)Nc2ccccc2NC(=O)COCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J09 compound treatment 1.37575534E8 -3.97E7 -0.5 1.71351344E8 -2750000.0 -0.05 -0.385 -0.7705 3063556 Maybridge4_001263 FC(F)(F)c1ccnc(n1)N2CCN(CCNC(=O)NC3CCCCC3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J10 compound treatment 1.36851127E8 -4.04E7 -0.51 1.67501287E8 -6600000.0 -0.11 -0.4381 -0.844 3178332 Maybridge4_001264 O=C(CSc1nccc(n1)c2cccs2)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J11 compound treatment 1.3522753E8 -4.2E7 -0.53 1.37889496E8 -3.62E7 -0.62 -0.8109 -0.9967 3178333 Maybridge4_001265 Clc1cc(ccc1NC(=O)C2CCN(CC2)C(=O)OCc3ccccc3)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J12 compound treatment 1.26755718E8 -5.05E7 -0.63 1.06799963E8 -6.73E7 -1.15 -1.2623 -0.9603 3063557 Maybridge4_001266 Cc1csc(NC(=O)c2ccccc2C(=O)O)c1c3nc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J13 compound treatment 1.5701888E8 -2.02E7 -0.25 1.30111683E8 -4.4E7 -0.75 -0.7117 -0.8958 3178334 Maybridge4_001267 Fc1cc(CNC(=O)c2ccc3nonc3c2)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J14 compound treatment 1.5181815E8 -2.54E7 -0.32 1.57002887E8 -1.71E7 -0.29 -0.4324 -0.9991 1272012 Maybridge4_001268 C1COc2cc(ccc2O1)c3cn4cccnc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J15 compound treatment 1.07715988E8 -6.95E7 -0.87 1.59339136E8 -1.48E7 -0.25 -0.7953 -0.8759 1207844 Maybridge4_001269 Cc1ccc(cc1)c2csc3ncnc(NCCN4CCNC4=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J16 compound treatment 1.3659243E8 -4.06E7 -0.51 1.74516709E8 419000.0 0.01 -0.3554 -0.6971 3063558 Maybridge4_001270 OC(=O)COCC(=O)Nc1cccc(c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J17 compound treatment 1.64451954E8 -1.28E7 -0.16 1.55810533E8 -1.83E7 -0.31 -0.3347 -0.9517 1592295 Maybridge4_001271 Cn1nc(c(NC(=O)c2ccc(F)cc2)c1C(C)(C)C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J18 compound treatment 1.52723331E8 -2.45E7 -0.31 1.53071047E8 -2.1E7 -0.36 -0.4719 -0.9969 1672779 Maybridge4_001272 O=C(Nc1ccccc1)Nc2ccc(C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J19 compound treatment 1.46263052E8 -3.1E7 -0.39 1.56383587E8 -1.77E7 -0.3 -0.4891 -0.9925 1287020 Maybridge4_001273 Nc1nccc(n1)c2nn(ccc2=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J20 compound treatment 1.52347788E8 -2.49E7 -0.31 1.79082238E8 4990000.0 0.09 -0.1604 -0.4956 1290569 Maybridge4_001274 CCOC(=O)N1CCC(CC1)NC(=O)c2ccccc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J21 compound treatment 1.59028873E8 -1.82E7 -0.23 1.56944878E8 -1.72E7 -0.29 -0.3691 -0.9923 1226002 Maybridge4_001275 Cc1nn(C)cc1NC(=O)Nc2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J22 compound treatment 1.54485312E8 -2.27E7 -0.29 1.47502798E8 -2.66E7 -0.46 -0.5237 -0.9747 3178335 Maybridge4_001276 O=C(Nc1ccccc1)N(CCC#N)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J23 mock treatment 1.50551058E8 -2.67E7 -0.33 1.60402107E8 -1.37E7 -0.23 -0.4025 -0.9848 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 J24 mock treatment 1.63253422E8 -1.4E7 -0.18 1.6696473E8 -7130000.0 -0.12 -0.2103 -0.9843 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K01 compound treatment 5.9880019E7 -1.17E8 -1.47 5.7679417E7 -1.16E8 -1.99 -2.4501 -0.9889 1539150 Maybridge4_001277 CC(C)(C)c1cc2ncnc(NC3CCN(Cc4ccccc4)CC3)c2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K02 compound treatment 7.5639054E7 -1.02E8 -1.27 8.5648876E7 -8.84E7 -1.51 -1.9718 -0.9963 1563937 Maybridge4_001278 COC(=O)c1c(C)oc(C)c1S(=O)(=O)Nc2ccc(cc2)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K03 compound treatment 7.1075671E7 -1.06E8 -1.33 8.1400519E7 -9.27E7 -1.59 -2.0637 -0.9962 3063559 Maybridge4_001279 CCC1CSc2nc3ccsc3c(=O)n12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K04 compound treatment 7.2320911E7 -1.05E8 -1.32 7.9526369E7 -9.46E7 -1.62 -2.0753 -0.9947 3178336 Maybridge4_001280 FC(F)(F)c1cccc(c1)N2CCN(CC2)C3=Cc4ccccc4CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K05 compound treatment 8.010206E7 -9.71E7 -1.22 7.6098827E7 -9.8E7 -1.68 -2.0478 -0.9877 3063560 Maybridge4_001281 FC(F)(F)c1ccnc(S)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K06 compound treatment 9.0105995E7 -8.71E7 -1.09 7.8546904E7 -9.56E7 -1.64 -1.9294 -0.9808 3178337 Maybridge4_001282 COC(=O)c1ccc(n1C)S(=O)(=O)Nc2ccc(cc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K07 compound treatment 1.03283174E8 -7.4E7 -0.93 9.3031837E7 -8.11E7 -1.39 -1.6372 -0.9808 1176274 Maybridge4_001283 CC1CC(CC(C)(C)C1)NC(=S)NC2CC3CC2C=C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K08 compound treatment 9.8055868E7 -7.92E7 -0.99 9.4321116E7 -7.98E7 -1.37 -1.668 -0.9878 1427567 Maybridge4_001284 Cc1ccc(C)n1c2ccc(cc2)C3(O)CCSc4ccccc43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K09 compound treatment 8.596009E7 -9.13E7 -1.14 8.1987929E7 -9.21E7 -1.58 -1.9245 -0.9877 1358302 Maybridge4_001285 CC(C)(C)OC(=O)N1CCC(CC1)c2nc(cs2)c3ccc(Cl)s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K10 compound treatment 1.05893247E8 -7.13E7 -0.89 9.6630132E7 -7.75E7 -1.33 -1.5705 -0.9817 1583408 Maybridge4_001286 COc1ccccc1CCNS(=O)(=O)c2ccc(C(=O)O)n2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K11 compound treatment 9.805927E7 -7.92E7 -0.99 7.6056829E7 -9.8E7 -1.68 -1.889 -0.9687 3178338 Maybridge4_001287 OC1(CCN(CC1)C(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K12 compound treatment 1.21154216E8 -5.61E7 -0.7 1.121974E8 -6.19E7 -1.06 -1.2467 -0.9802 3063561 Maybridge4_001288 OC1(NC(=O)c2cnn(c2C(F)(F)F)c3ccccc3)C(=O)c4ccccc4C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K13 compound treatment 1.09109322E8 -6.81E7 -0.85 8.9672984E7 -8.44E7 -1.45 -1.6262 -0.9686 3178339 Maybridge4_001289 COc1ccc(NC(=O)c2ccccc2C(F)(F)F)cc1OC3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K14 compound treatment 1.10746397E8 -6.65E7 -0.83 7.8022231E7 -9.61E7 -1.64 -1.7527 -0.9505 1513815 Maybridge4_001290 CC(C)(C)OC(=O)N1CCC(CNS(=O)(=O)c2cccc3cccnc23)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K15 compound treatment 1.39237061E8 -3.8E7 -0.48 9.2972835E7 -8.11E7 -1.39 -1.319 -0.8984 1269818 Maybridge4_001291 Cc1cc(NS(=O)(=O)c2ccc(NCN3C(=O)c4ccccc4C3=O)cc2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K16 compound treatment 1.14542689E8 -6.27E7 -0.79 7.1068101E7 -1.03E8 -1.76 -1.8032 -0.9338 3178340 Maybridge4_001292 CC(C)NC(=O)CSc1nnc(c2ccc(cc2)C(C)(C)C)n1c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K17 compound treatment 1.35257661E8 -4.2E7 -0.53 1.13652547E8 -6.04E7 -1.03 -1.104 -0.9509 1222771 Maybridge4_001293 NC(=O)C1CCN(CC(O)COc2ccc(F)cc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K18 compound treatment 7.6037257E7 -1.01E8 -1.27 8.0944524E7 -9.32E7 -1.59 -2.0252 -0.9936 1223041 Maybridge4_001294 CC(=O)Nc1cccc(c1)n2nnc(SCc3cc(Cl)cc4COCOc34)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K19 compound treatment 1.19344809E8 -5.79E7 -0.73 1.03443106E8 -7.07E7 -1.21 -1.3687 -0.9702 1546521 Maybridge4_001295 COc1ccc2[nH]c(cc2c1)C(=O)N3CCC(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K20 compound treatment 1.45624766E8 -3.16E7 -0.4 1.24156926E8 -4.99E7 -0.85 -0.8849 -0.939 1729108 Maybridge4_001296 Cc1oc(cc1c2nc(no2)c3ccc(F)cc3)S(=O)(=O)N4CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K21 compound treatment 1.2846087E8 -4.88E7 -0.61 1.21332826E8 -5.28E7 -0.9 -1.0713 -0.982 3178447 Maybridge4_001297 Cc1ccc(C)n1c2nn(c3cccc(F)c23)S(=O)(=O)c4cccc(c4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K22 compound treatment 1.4340835E8 -3.38E7 -0.42 1.0163248E8 -7.25E7 -1.24 -1.1772 -0.8979 1411945 Maybridge4_001298 Cc1ccc(Oc2ncccc2NS(=O)(=O)c3ccc(s3)c4ccccn4)c5CCCc51 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K23 mock treatment 9.9602301E7 -7.76E7 -0.97 1.0234059E8 -7.18E7 -1.23 -1.5572 -0.9934 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 K24 mock treatment 1.41728124E8 -3.55E7 -0.45 1.16977671E8 -5.71E7 -0.98 -1.0063 -0.9366 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L01 compound treatment 1.29315107E8 -4.79E7 -0.6 1.20205632E8 -5.39E7 -0.92 -1.0774 -0.9785 3178448 Maybridge4_001299 COCc1cc(O)nc(SCC(=O)c2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L02 compound treatment 1.28136814E8 -4.91E7 -0.62 8.7921995E7 -8.62E7 -1.48 -1.4786 -0.925 3063562 Maybridge4_001300 Fc1ccc(cc1)S(=O)(=O)N2CCCN(CC2)c3nccc(n3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L03 compound treatment 7.5687513E7 -1.02E8 -1.27 6.7397726E7 -1.07E8 -1.83 -2.1923 -0.9845 3178449 Maybridge4_001301 Nc1nc(SCC(=O)c2cc(no2)c3ccccc3)ncc1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L04 compound treatment 9.4620775E7 -8.26E7 -1.04 8.2379418E7 -9.17E7 -1.57 -1.843 -0.9797 1497829 Maybridge4_001302 CCCNC(=O)Nc1cc(ccc1O)S(=O)(=O)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L05 compound treatment 8.6687458E7 -9.05E7 -1.14 8.788717E7 -8.62E7 -1.48 -1.8467 -0.9916 1614464 Maybridge4_001303 OC(CN(CCN1CCNC1=O)CC(O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L06 compound treatment 8.5173335E7 -9.21E7 -1.15 9.9093991E7 -7.5E7 -1.28 -1.7245 -0.9986 1416766 Maybridge4_001304 Clc1ccc2scc(CNS(=O)(=O)c3cc(cs3)S(=O)(=O)c4ccccc4)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L07 compound treatment 1.44296386E8 -3.29E7 -0.41 7.7169245E7 -9.69E7 -1.66 -1.4654 -0.857 3063563 Maybridge4_001305 O=C(Nc1ccc2COC(=O)c2c1)c3cc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L08 compound treatment 1.24466411E8 -5.28E7 -0.66 9.6971475E7 -7.71E7 -1.32 -1.4016 -0.949 3178450 Maybridge4_001306 Cc1cc(NC(=O)NCCNc2ncccc2C(F)(F)F)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L09 compound treatment 9.6688847E7 -8.05E7 -1.01 9.0206184E7 -8.39E7 -1.44 -1.7299 -0.9852 3178451 Maybridge4_001307 FC(F)(F)c1ccnc(n1)N2CCN(CCNC(=O)c3cccs3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L10 compound treatment 8.1249773E7 -9.6E7 -1.2 1.06041293E8 -6.81E7 -1.16 -1.6752 -0.9999 3063564 Maybridge4_001308 O=C(CSc1nccc(n1)c2cccs2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L11 compound treatment 1.28901915E8 -4.83E7 -0.61 8.905792E7 -8.5E7 -1.46 -1.4581 -0.9246 1340769 Maybridge4_001309 Cc1c(csc1C(=O)NC2CCN(Cc3ccccc3)CC2)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L12 compound treatment 1.35992502E8 -4.12E7 -0.52 1.14549183E8 -5.95E7 -1.02 -1.0866 -0.9506 1452839 Maybridge4_001310 Clc1cccc(Oc2ccccc2)c1CNC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L13 compound treatment 1.1740265E8 -5.98E7 -0.75 7.0442384E7 -1.04E8 -1.77 -1.7854 -0.9267 1545947 Maybridge4_001311 Cc1ccc(cc1)S(=O)(=O)NC(=O)OCCn2ncc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L14 compound treatment 1.2870757E8 -4.85E7 -0.61 1.1785178E8 -5.62E7 -0.96 -1.1113 -0.9755 1335669 Maybridge4_001312 O=C(Nc1ccccc1)Nc2ccccc2C(=O)NCC3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L15 compound treatment 1.65404207E8 -1.18E7 -0.15 1.16008083E8 -5.81E7 -0.99 -0.8081 -0.8037 1301958 Maybridge4_001313 O=C1NCCN1CCNc2cccc(C#N)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L16 compound treatment 1.15507374E8 -6.17E7 -0.77 1.08106714E8 -6.6E7 -1.13 -1.3463 -0.983 1237826 Maybridge4_001314 OC(=O)c1cccc(NC(=O)c2nccnc2C(=O)O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L17 compound treatment 9.4652831E7 -8.26E7 -1.04 1.14583701E8 -5.95E7 -1.02 -1.4529 -1.0 1167798 Maybridge4_001315 CCOC(=O)C1CCN(CC1)c2ccccc2CN3CCCc4cc(C)ccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L18 compound treatment 1.27367521E8 -4.99E7 -0.63 6.5712081E7 -1.08E8 -1.86 -1.7543 -0.896 1532681 Maybridge4_001316 O=C(NCC1CC1)c2ccccc2NS(=O)(=O)c3cccc4nonc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L19 compound treatment 8.584996E7 -9.14E7 -1.15 7.5855497E7 -9.82E7 -1.68 -1.9997 -0.9826 3178452 Maybridge4_001317 COc1ccc(OCCNC(=O)c2nccnc2C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L20 compound treatment 1.24886817E8 -5.23E7 -0.66 6.4701492E7 -1.09E8 -1.87 -1.7885 -0.9013 3063588 Maybridge4_001318 OC(=O)COCC(=O)Nc1ccc(cc1)n2ccc(n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L21 compound treatment 1.3051471E8 -4.67E7 -0.59 9.0184725E7 -8.39E7 -1.44 -1.4301 -0.9218 1125657 Maybridge4_001319 NC(=O)C1CCN(CC1)C(=O)Nc2cc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L22 compound treatment 1.29609199E8 -4.76E7 -0.6 1.3037783E8 -4.37E7 -0.75 -0.9516 -0.9938 3063589 Maybridge4_001320 Cc1ccc(cc1)S(=O)(=O)CCSCc2csc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L23 mock treatment 1.29952751E8 -4.73E7 -0.59 1.17565272E8 -5.65E7 -0.97 -1.1037 -0.9724 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 L24 mock treatment 1.44355181E8 -3.29E7 -0.41 1.24790205E8 -4.93E7 -0.84 -0.8885 -0.9458 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M01 compound treatment 5.4462131E7 -1.23E8 -1.54 8.314688E7 -9.1E7 -1.56 -2.1899 -1.0 1132483 Maybridge4_001321 N(c1ccccc1)c2ncnc3cc(sc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M02 compound treatment 8.0129667E7 -9.71E7 -1.22 9.5927288E7 -7.82E7 -1.34 -1.8075 -0.9989 1732345 Maybridge4_001322 OC(=O)CSCC(=O)N1CCN(CC1)S(=O)(=O)c2cc(Cl)cc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M03 compound treatment 8.184561E7 -9.54E7 -1.2 1.01287805E8 -7.28E7 -1.25 -1.7274 -0.9998 1627433 Maybridge4_001323 NCCNC(=O)Cc1ccc(O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M04 compound treatment 9.1599778E7 -8.56E7 -1.07 1.05302626E8 -6.88E7 -1.18 -1.5923 -0.9989 1237825 Maybridge4_001324 O=C(Nc1nc2ccccc2c(=O)s1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M05 compound treatment 9.9764486E7 -7.75E7 -0.97 1.241853E8 -4.99E7 -0.85 -1.2913 -0.9979 1700739 Maybridge4_001325 OC(CSc1cccs1)CSc2ccccc2NC(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M06 compound treatment 1.05060836E8 -7.22E7 -0.91 1.21210266E8 -5.29E7 -0.91 -1.2804 -1.0 1271443 Maybridge4_001326 COC(=O)c1ccc(n1C)S(=O)(=O)Nc2ccsc2C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M07 compound treatment 1.05453388E8 -7.18E7 -0.9 1.20874778E8 -5.32E7 -0.91 -1.2809 -1.0 3063590 Maybridge4_001327 S=C(NC(Cc1ccccc1)c2ccccc2)NC3CC4CC3C=C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M08 compound treatment 8.3132503E7 -9.41E7 -1.18 1.05456506E8 -6.86E7 -1.17 -1.6656 -1.0 1434508 Maybridge4_001328 Fc1ccc2[nH]cc(CCCN3CCN(CC3)c4nc5cc(Cl)ccc5s4)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M09 compound treatment 9.9478132E7 -7.78E7 -0.98 1.18074495E8 -5.6E7 -0.96 -1.3678 -1.0 1293074 Maybridge4_001329 COC(=O)c1cc(oc1C)S(=O)(=O)Nc2nn(C)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M10 compound treatment 1.05631467E8 -7.16E7 -0.9 1.28999596E8 -4.51E7 -0.77 -1.181 -0.9972 1681613 Maybridge4_001330 O=C(NCc1ccc2OCOc2c1)c3cc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M11 compound treatment 1.15095263E8 -6.21E7 -0.78 1.36428506E8 -3.77E7 -0.64 -1.0071 -0.9956 1565655 Maybridge4_001331 CC(C)(C)c1ccc(cc1)S(=O)(=O)N2CCC(O)(CC2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M12 compound treatment 1.28339157E8 -4.89E7 -0.61 1.53016662E8 -2.11E7 -0.36 -0.6889 -0.968 1050571 Maybridge4_001332 OC(=O)CCc1cccnc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M13 compound treatment 1.15758617E8 -6.15E7 -0.77 1.251492E8 -4.89E7 -0.84 -1.1378 -0.9991 1126449 Maybridge4_001333 COc1ccc(NC(=O)C2CCCCC2)cc1OC3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M14 compound treatment 1.377598E8 -3.95E7 -0.5 1.30838386E8 -4.33E7 -0.74 -0.8738 -0.9809 1537113 Maybridge4_001334 CC(C)(C)OC(=O)N1CCC(CNS(=O)(=O)c2ccc3OCCOc3c2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M15 compound treatment 1.31858003E8 -4.54E7 -0.57 1.50131067E8 -2.4E7 -0.41 -0.6926 -0.9871 1458162 Maybridge4_001335 CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)N3C(=O)CSCC3=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M16 compound treatment 1.56399251E8 -2.08E7 -0.26 1.32795806E8 -4.13E7 -0.71 -0.6847 -0.9084 1342126 Maybridge4_001336 NC(=O)NC(=O)Cc1nc2ccccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M17 compound treatment 1.27198147E8 -5.0E7 -0.63 1.48411224E8 -2.57E7 -0.44 -0.7547 -0.9848 1668027 Maybridge4_001337 OC(CNC1Cc2ccccc2C1)COc3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M18 compound treatment 9.682489E7 -8.04E7 -1.01 1.23972789E8 -5.01E7 -0.86 -1.32 -0.9968 3063591 Maybridge4_001338 OC(=O)CSc1nc2cccnc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M19 compound treatment 8.5794508E7 -9.14E7 -1.15 1.37168794E8 -3.69E7 -0.63 -1.2581 -0.9606 1290479 Maybridge4_001339 NC(=O)C1CCN(CC(O)COc2ccc3OCOc3c2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M20 compound treatment 1.1507575E8 -6.22E7 -0.78 1.37956915E8 -3.61E7 -0.62 -0.9888 -0.9934 1132021 Maybridge4_001340 COC(=O)c1scc(C)c1NS(=O)(=O)c2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M21 compound treatment 1.11370174E8 -6.59E7 -0.83 1.17758411E8 -5.63E7 -0.96 -1.2662 -0.997 1157417 Maybridge4_001341 COc1ccc(cc1OC)S(=O)(=O)n2nc(n3c(C)ccc3C)c4c(F)cccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M22 compound treatment 1.2150203E8 -5.57E7 -0.7 1.33460109E8 -4.06E7 -0.7 -0.9862 -1.0 1722963 Maybridge4_001342 Cc1nc(cn1C)S(=O)(=O)N2CCC(CC2)NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M23 mock treatment 1.11873774E8 -6.54E7 -0.82 1.38009878E8 -3.61E7 -0.62 -1.0166 -0.9903 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 M24 mock treatment 1.34518435E8 -4.27E7 -0.54 1.28363073E8 -4.57E7 -0.78 -0.9325 -0.9829 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N01 compound treatment 1.27536204E8 -4.97E7 -0.62 1.26740672E8 -4.74E7 -0.81 -1.0141 -0.9916 1329289 Maybridge4_001343 OC(=O)c1ccccc1C(=O)NCCN2CCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N02 compound treatment 1.30229153E8 -4.7E7 -0.59 1.23226913E8 -5.09E7 -0.87 -1.0327 -0.982 3178453 Maybridge4_001344 FC(F)(F)c1ccnc(n1)N2CCCN(CC2)S(=O)(=O)c3cccc4nonc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N03 compound treatment 8.3702538E7 -9.35E7 -1.17 1.20079253E8 -5.4E7 -0.92 -1.4835 -0.9931 1118431 Maybridge4_001345 CCOC(=O)c1cc(NC(=O)CC(C)(C)CC(=O)O)ccc1N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N04 compound treatment 1.23171514E8 -5.41E7 -0.68 1.27801207E8 -4.63E7 -0.79 -1.0399 -0.997 1615128 Maybridge4_001346 CCS(=O)(=O)c1ccc(O)c(NC(=O)Nc2ccccc2OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N05 compound treatment 1.22001929E8 -5.52E7 -0.69 1.25211468E8 -4.89E7 -0.84 -1.0817 -0.9956 3178454 Maybridge4_001347 Cc1nc(cn1C)S(=O)(=O)NCCNc2ccc(nn2)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N06 compound treatment 1.36701903E8 -4.05E7 -0.51 1.37674285E8 -3.64E7 -0.62 -0.8004 -0.9949 3063592 Maybridge4_001348 FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc2ccc3COC(=O)c3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N07 compound treatment 1.07354277E8 -6.99E7 -0.88 1.82410475E8 8310000.0 0.14 -0.5192 -0.5847 1059288 Maybridge4_001349 O=C1NC(Nc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N08 compound treatment 1.20676001E8 -5.66E7 -0.71 1.44307238E8 -2.98E7 -0.51 -0.8623 -0.9869 3063593 Maybridge4_001350 Cc1cc(NC(=O)Nc2ccccc2)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N09 compound treatment 1.27858641E8 -4.94E7 -0.62 1.1952083E8 -5.46E7 -0.93 -1.0986 -0.9801 3178455 Maybridge4_001351 COc1cccc(c1)C(=O)NCCN2CCN(CC2)c3nccc(n3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N10 compound treatment 8.2302873E7 -9.49E7 -1.19 8.064747E7 -9.34E7 -1.6 -1.9732 -0.9894 1126742 Maybridge4_001352 Cc1cc(NC(=O)CCCC(=O)O)n(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N11 compound treatment 1.20792328E8 -5.64E7 -0.71 8.9274115E7 -8.48E7 -1.45 -1.5274 -0.9455 1374549 Maybridge4_001353 COc1ccccc1C2CCN(CC2)C(=O)c3scc(c3C)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N12 compound treatment 1.25425007E8 -5.18E7 -0.65 1.23076858E8 -5.1E7 -0.87 -1.0771 -0.9894 1540730 Maybridge4_001354 Cc1oc(cc1C(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N13 compound treatment 1.09097854E8 -6.81E7 -0.85 1.2089468E8 -5.32E7 -0.91 -1.2484 -0.9995 1417640 Maybridge4_001355 O=C(Nc1cccc2ccccc12)OCCn3ncc4ccccc4c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N14 compound treatment 1.2932591E8 -4.79E7 -0.6 1.29710472E8 -4.44E7 -0.76 -0.9622 -0.9933 1318344 Maybridge4_001356 COC(=O)c1sccc1S(=O)(=O)Nc2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N15 compound treatment 1.18713392E8 -5.85E7 -0.73 1.37490144E8 -3.66E7 -0.63 -0.9622 -0.9969 3178549 Maybridge4_001357 FC(F)(F)Oc1ccc(NC(=S)NCCN2CCNC2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N16 compound treatment 1.20964506E8 -5.63E7 -0.71 1.34571718E8 -3.95E7 -0.68 -0.9776 -0.9998 1460315 Maybridge4_001358 COc1ccc(OCC(O)CNC(=O)c2cc(nn2C)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N17 compound treatment 1.26384507E8 -5.08E7 -0.64 1.10940176E8 -6.32E7 -1.08 -1.2155 -0.9683 1196797 Maybridge4_001359 CCCc1c(cnn1c2ccccc2)C(=O)NC3CCN(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N18 compound treatment 1.24032125E8 -5.32E7 -0.67 1.18370511E8 -5.57E7 -0.95 -1.1465 -0.9847 3178550 Maybridge4_001360 COc1cc(OCc2ccccc2)ccc1CN3CCN(CC3)c4ccc(cn4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N19 compound treatment 8.6100961E7 -9.11E7 -1.14 1.33314565E8 -4.08E7 -0.7 -1.302 -0.972 1300856 Maybridge4_001361 O=C(NC1Cc2ccccc2C1)Nc3cc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N20 compound treatment 1.30541423E8 -4.67E7 -0.59 1.45289028E8 -2.88E7 -0.49 -0.7629 -0.9963 1617412 Maybridge4_001362 OC(=O)CC(CC(=O)N1CCN(CC1)C(=O)c2ccco2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N21 compound treatment 1.21455525E8 -5.58E7 -0.7 1.31809901E8 -4.23E7 -0.72 -1.0066 -0.9999 1534103 Maybridge4_001363 OC(COc1ccc(cc1)c2csnn2)CN3CCN(CC3)C(c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N22 compound treatment 1.25459325E8 -5.18E7 -0.65 1.45632211E8 -2.85E7 -0.49 -0.8038 -0.99 3063594 Maybridge4_001364 Clc1ccc(c(Cl)c1)S(=O)(=O)CCSCc2csc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N23 mock treatment 1.22265583E8 -5.5E7 -0.69 1.30993712E8 -4.31E7 -0.74 -1.0093 -0.9994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 N24 mock treatment 1.27211697E8 -5.0E7 -0.63 1.29916283E8 -4.42E7 -0.76 -0.9785 -0.9957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O01 compound treatment 1.31193671E8 -4.6E7 -0.58 1.21143316E8 -5.3E7 -0.91 -1.0494 -0.9763 1379542 Maybridge4_001365 CC(C)(C)c1cc2ncnc(N3CCCCC3)c2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O02 compound treatment 1.45568078E8 -3.17E7 -0.4 1.46049153E8 -2.8E7 -0.48 -0.6204 -0.9956 1268570 Maybridge4_001366 Cc1cc(OCC(=O)N(C2CCCCC2)c3ccccc3)c4ccccc4n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O03 compound treatment 1.63157073E8 -1.41E7 -0.18 1.69942159E8 -4160000.0 -0.07 -0.1752 -0.9201 3063595 Maybridge4_001367 FC(F)(F)c1ccn(n1)S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O04 compound treatment 1.63605544E8 -1.36E7 -0.17 1.65056112E8 -9040000.0 -0.15 -0.2303 -0.9988 1471781 Maybridge4_001368 Cc1csc2c(=O)sc(NC(=O)c3cccs3)nc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O05 compound treatment 1.65336231E8 -1.19E7 -0.15 1.88362224E8 1.43E7 0.24 0.0671 0.2345 3178551 Maybridge4_001369 COC(=O)c1cn(Cc2ccc(Cl)cc2)cc(F)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O06 compound treatment 1.71180226E8 -6050000.0 -0.08 1.77692073E8 3590000.0 0.06 -0.0102 -0.1043 1122209 Maybridge4_001370 COC(=O)c1ccc(n1C)S(=O)(=O)N2CCCN(Cc3ccccc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O07 compound treatment 1.74158665E8 -3080000.0 -0.04 1.98985267E8 2.49E7 0.43 0.274 0.6404 1177633 Maybridge4_001371 CC(C)(CCO)NC(=S)NC1CC2CC1C=C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O08 compound treatment 1.72671331E8 -4560000.0 -0.06 1.92796761E8 1.87E7 0.32 0.1859 0.5716 1162225 Maybridge4_001372 CCNC(=O)c1c(C)onc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O09 compound treatment 1.67586119E8 -9650000.0 -0.12 1.90668138E8 1.66E7 0.28 0.115 0.3729 3063596 Maybridge4_001373 Cc1csc2c(NCCCN3CCOCC3)ncnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O10 compound treatment 1.68786561E8 -8450000.0 -0.11 1.88465426E8 1.44E7 0.25 0.099 0.3696 3178552 Maybridge4_001374 COc1ccc(cc1)c2cc(C(=O)Nc3ccc(F)cc3)c(o2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O11 compound treatment 1.75640191E8 -1590000.0 -0.02 1.83922695E8 9830000.0 0.17 0.1048 0.6187 3063597 Maybridge4_001375 Fc1ccc(cc1)S(=O)(=O)N2CCN=C(C=C2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O12 compound treatment 1.88937408E8 1.17E7 0.15 1.94753895E8 2.07E7 0.35 0.3538 0.9242 1566889 Maybridge4_001376 O=C(Nc1ccc2OCCOc2c1)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O13 compound treatment 1.88519756E8 1.13E7 0.14 1.89124249E8 1.5E7 0.26 0.282 0.9604 3178553 Maybridge4_001377 CC(=O)Nc1c(c(nn1C)C(F)(F)F)c2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O14 compound treatment 1.87998571E8 1.08E7 0.14 1.83127875E8 9030000.0 0.15 0.2048 0.9977 1314147 Maybridge4_001378 CC(C)(C)OC(=O)N1CCC(CNS(=O)(=O)c2cc(Cl)sc2Cl)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O15 compound treatment 1.93788636E8 1.66E7 0.21 1.48175517E8 -2.59E7 -0.44 -0.1669 -0.3407 1617882 Maybridge4_001379 OC(=O)CC1(CC(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4)CCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O16 compound treatment 1.54167782E8 -2.31E7 -0.29 1.24227139E8 -4.99E7 -0.85 -0.8082 -0.8967 3063620 Maybridge4_001380 Cc1nc(nc(SCC(=O)c2ccc(F)cc2)c1Cl)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O17 compound treatment 2.06718206E8 2.95E7 0.37 1.96505562E8 2.24E7 0.38 0.5328 0.9998 1499688 Maybridge4_001381 NC(=O)C1CCN(Cn2nnc3ccccc23)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O18 compound treatment 1.81340015E8 4110000.0 0.05 1.51015087E8 -2.31E7 -0.4 -0.243 -0.6098 1432924 Maybridge4_001382 COc1ccc(CCNC(=O)c2cc3ccccc3s2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O19 compound treatment 1.80293417E8 3060000.0 0.04 1.98807214E8 2.47E7 0.42 0.3262 0.7681 1075902 Maybridge4_001383 COc1ccccc1NC(=O)Nc2ccccc2OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O20 compound treatment 1.82682523E8 5450000.0 0.07 1.95805496E8 2.17E7 0.37 0.3111 0.8233 3063621 Maybridge4_001384 Fc1ccc(cc1)S(=O)(=O)CCN2CCN=C(C=C2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O21 compound treatment 1.95550252E8 1.83E7 0.23 2.04200436E8 3.01E7 0.52 0.5268 0.9338 1600262 Maybridge4_001385 O=C(CC1(CC2CC3CC(C2)C1)C3)NCc4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O22 compound treatment 1.92890683E8 1.57E7 0.2 1.95613699E8 2.15E7 0.37 0.3993 0.9567 1226207 Maybridge4_001386 OC(=O)CCn1nc(ccc1=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O23 mock treatment 1.86300538E8 9070000.0 0.11 1.74087482E8 -9740.0 0.0 0.0803 0.7061 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 O24 mock treatment 2.10368207E8 3.31E7 0.42 1.91198204E8 1.71E7 0.29 0.5009 0.9853 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P01 compound treatment 1.87983327E8 1.07E7 0.13 1.85469661E8 1.14E7 0.19 0.233 0.9839 1550189 Maybridge4_001387 Cc1ccc(cc1)C(=O)NCCN2CCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P02 compound treatment 1.8960426E8 1.24E7 0.16 2.0856993E8 3.45E7 0.59 0.527 0.8637 3178554 Maybridge4_001388 Cc1ccsc1CNC(=O)Nc2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P03 compound treatment 9.235671E7 -8.49E7 -1.06 1.4152707E8 -3.26E7 -0.56 -1.1471 -0.9544 3063622 Maybridge4_001389 CCOC(=O)C(C#N)C1C(=C(N)Oc2c(C)cc(Cl)cc12)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P04 compound treatment 1.82211679E8 4980000.0 0.06 1.85423219E8 1.13E7 0.19 0.1812 0.8898 1160881 Maybridge4_001390 COC(=O)c1sccc1c2ccc(CN3CCCc4cc(OC)ccc34)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P05 compound treatment 1.94399687E8 1.72E7 0.22 1.37312108E8 -3.68E7 -0.63 -0.293 -0.4403 1537339 Maybridge4_001391 COC(=O)c1sccc1S(=O)(=O)NC2CCS(=O)(=O)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P06 compound treatment 1.80072998E8 2840000.0 0.04 1.9040893E8 1.63E7 0.28 0.2226 0.7909 3178555 Maybridge4_001392 O=C1OCc2ccc(NS(=O)(=O)c3ccccc3C#N)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P07 compound treatment 1.62332864E8 -1.49E7 -0.19 1.70508684E8 -3590000.0 -0.06 -0.1756 -0.8925 1343805 Maybridge4_001393 O=C(NC1CCN(Cc2ccccc2)CC1)Nc3cc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P08 compound treatment 1.85463145E8 8230000.0 0.1 1.99546523E8 2.54E7 0.44 0.381 0.8511 3063623 Maybridge4_001394 Cc1cc(NC(=O)NCc2ccccc2)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P09 compound treatment 1.81633092E8 4400000.0 0.06 1.96040311E8 2.19E7 0.38 0.3046 0.8024 3178556 Maybridge4_001395 FC(F)(F)c1ccnc(n1)N2CCN(CCNC(=O)c3ccc(Cl)cc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P10 compound treatment 1.66273185E8 -1.1E7 -0.14 1.26690296E8 -4.74E7 -0.81 -0.6711 -0.8153 1315475 Maybridge4_001396 Cc1oc(cc1C(=O)NCc2csc3ccc(Cl)cc23)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P11 compound treatment 1.7243047E8 -4800000.0 -0.06 1.7209728E8 -2000000.0 -0.03 -0.0668 -0.9641 1707754 Maybridge4_001397 Cc1c(csc1C(=O)N2CCCc3cc(C)ccc23)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P12 compound treatment 1.78896623E8 1660000.0 0.02 1.9090109E8 1.68E7 0.29 0.2181 0.7564 1437749 Maybridge4_001398 CC(C)c1ccc(NC(=O)c2cc(oc2C)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P13 compound treatment 1.80235541E8 3000000.0 0.04 1.91599508E8 1.75E7 0.3 0.2385 0.7897 3178557 Maybridge4_001399 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2ccc(COC(=O)c3cccs3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P14 compound treatment 2.21028775E8 4.38E7 0.55 2.20100541E8 4.6E7 0.79 0.9453 0.9845 1200741 Maybridge4_001400 CC(C)(CC(=O)O)CC(=O)N1CCN(CC1)c2ncccc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P15 compound treatment 1.33691013E8 -4.35E7 -0.55 1.88007017E8 1.39E7 0.24 -0.2179 -0.3656 1650074 Maybridge4_001401 CCOC(=O)c1ccc(NC(=S)NCCN2CCNC2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P16 compound treatment 2.08951603E8 3.17E7 0.4 1.64932766E8 -9160000.0 -0.16 0.1704 0.3985 1225431 Maybridge4_001402 COc1ccc(OCC(O)CNC(=O)c2cccnc2Oc3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P17 compound treatment 1.9206771E8 1.48E7 0.19 1.86963933E8 1.29E7 0.22 0.2873 0.9965 1670405 Maybridge4_001403 CCCc1c(cnn1c2ccccc2)C(=O)NC3Cc4ccccc4C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P18 compound treatment 1.67788715E8 -9450000.0 -0.12 1.53932833E8 -2.02E7 -0.35 -0.3279 -0.8984 1600703 Maybridge4_001404 COc1cc(OCc2ccccc2)ccc1CN3CCC(CC3)C(=O)c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P19 compound treatment 1.95550979E8 1.83E7 0.23 1.96209644E8 2.21E7 0.38 0.4301 0.9714 1497768 Maybridge4_001405 Fc1ccc(NC(=O)Nc2cc3ccccc3s2)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P20 compound treatment 1.82459449E8 5220000.0 0.07 1.90534532E8 1.64E7 0.28 0.2453 0.8491 1490941 Maybridge4_001406 Cc1nnsc1C(=O)NCc2c(Cl)cccc2Sc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P21 compound treatment 1.77904878E8 670000.0 0.01 1.80174054E8 6080000.0 0.1 0.0795 0.7618 1271550 Maybridge4_001407 OC(CNCc1ccc2OCOc2c1)COc3ccc(cc3)c4csnn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P22 compound treatment 1.82373337E8 5140000.0 0.06 1.83049708E8 8950000.0 0.15 0.1539 0.926 3063624 Maybridge4_001408 CC1(C)CCc2cc(CN3CCN(CC3)c4ncc(cc4Cl)C(F)(F)F)ccc2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P23 mock treatment 1.89516394E8 1.23E7 0.15 1.85677181E8 1.16E7 0.2 0.2491 0.9922 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2052 P24 mock treatment 1.97345012E8 2.01E7 0.25 1.9481992E8 2.07E7 0.35 0.4292 0.9861 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A01 compound treatment 3.6160034E7 -1.69E8 -2.12 1.69392347E8 -1.87E7 -0.32 -1.7238 -0.8047 1291502 Maybridge4_001409 Fc1ccc(cc1)c2n[nH]cc2CN3CCN(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A02 compound treatment 5.0580859E7 -1.54E8 -1.94 1.72666085E8 -1.54E7 -0.26 -1.5562 -0.796 1286225 Maybridge4_001410 O=C(NC1CCN(CC1)C(=O)OCc2ccccc2)Nc3ccccc3N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A03 compound treatment 5.2250797E7 -1.53E8 -1.92 1.91333548E8 3270000.0 0.06 -1.3155 -0.6862 1251898 Maybridge4_001411 Cc1cc(C)c(SCC(=O)NCc2ccc3OCOc3c2)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A04 compound treatment 6.7285348E7 -1.38E8 -1.73 2.12932988E8 2.49E7 0.43 -0.9207 -0.5174 1262294 Maybridge4_001412 CCCCN1Cc2c([nH]c3cc(nn3c2=O)C(C)(C)C)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A05 compound treatment 9.5231963E7 -1.1E8 -1.38 1.99471417E8 1.14E7 0.2 -0.8357 -0.6009 1594634 Maybridge4_001413 OC(=O)CCCC(=O)NC1CCCc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A06 compound treatment 1.16479615E8 -8.85E7 -1.11 1.87804891E8 -263000.0 0.0 -0.7884 -0.71 3178643 Maybridge4_001414 COc1cc2CCN(Cc3sc4ccccc4c3C)C(C)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A07 compound treatment 1.41423677E8 -6.36E7 -0.8 2.02148703E8 1.41E7 0.24 -0.3936 -0.4723 1319283 Maybridge4_001415 OC(CNC(=O)Nc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A08 compound treatment 1.53890286E8 -5.11E7 -0.64 2.02527794E8 1.45E7 0.25 -0.2784 -0.405 1715585 Maybridge4_001416 Cc1cccc(NC(=O)c2ccco2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A09 compound treatment 1.50311469E8 -5.47E7 -0.69 2.03979223E8 1.59E7 0.27 -0.2926 -0.3963 1554836 Maybridge4_001417 CCCc1cnc(nc1)N2CCN(CC2)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A10 compound treatment 1.32031225E8 -7.3E7 -0.92 1.75008974E8 -1.31E7 -0.22 -0.8054 -0.8547 3178644 Maybridge4_001418 O=S(=O)(Nc1ccccc1N2CCOCC2)c3ccc(s3)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A11 compound treatment 1.61979391E8 -4.3E7 -0.54 2.0513888E8 1.71E7 0.29 -0.175 -0.2852 3178645 Maybridge4_001419 Cc1ccc(cc1)n2nc(cc2c3cccs3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A12 compound treatment 1.74627435E8 -3.04E7 -0.38 2.14069517E8 2.6E7 0.45 0.0453 0.0772 3063626 Maybridge4_001420 Oc1nnc(S)n1C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A13 compound treatment 1.83822795E8 -2.12E7 -0.27 2.07910684E8 1.98E7 0.34 0.0523 0.1212 3178646 Maybridge4_001421 CN(C(=O)c1c(C)onc1c2c(Cl)cccc2Cl)c3nnc(s3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A14 compound treatment 1.91254972E8 -1.38E7 -0.17 2.13138048E8 2.51E7 0.43 0.1815 0.3924 3063627 Maybridge4_001422 N#Cc1sc2nc3ccccc3n2c1/N=C/N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A15 compound treatment 1.89954525E8 -1.51E7 -0.19 2.17949329E8 2.99E7 0.51 0.2282 0.4185 3178647 Maybridge4_001423 FC(F)(F)c1ccnc(n1)N2CCC(CC2)C(=O)Oc3ccccc3N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A16 compound treatment 1.91206599E8 -1.38E7 -0.17 2.19747893E8 3.17E7 0.54 0.2611 0.4586 1004868 Maybridge4_001424 Sc1ncnc2n(ncc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A17 compound treatment 1.76370813E8 -2.86E7 -0.36 1.9488018E8 6810000.0 0.12 -0.1715 -0.4542 1225276 Maybridge4_001425 COc1ccc(NC(=O)CC2N(CCNC2=O)C(=O)c3ccc(cc3)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A18 compound treatment 1.79431367E8 -2.56E7 -0.32 2.0470808E8 1.66E7 0.28 -0.0254 -0.0593 1212340 Maybridge4_001426 COc1ccc(cc1)C(=O)Nc2ccc(nc2)N3CCN(CC3)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A19 compound treatment 1.85254743E8 -1.98E7 -0.25 2.00059533E8 1.2E7 0.21 -0.0301 -0.0934 1490823 Maybridge4_001427 Fc1ccc(cc1)c2cn3cccc(OCc4ccc(Cl)c(Cl)c4)c3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A20 compound treatment 2.0584037E8 835000.0 0.01 2.01091407E8 1.3E7 0.22 0.165 0.7395 1164040 Maybridge4_001428 Oc1ccccc1C(=O)Nc2ccc(NC(=O)Nc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A21 compound treatment 2.08017702E8 3010000.0 0.04 1.98869396E8 1.08E7 0.18 0.1575 0.8344 1589639 Maybridge4_001429 O=C(Nc1ccc(OCc2ccccc2)cc1)N3CCN(CC3)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A22 compound treatment 2.05400641E8 395000.0 0.0 2.03744688E8 1.57E7 0.27 0.1933 0.72 1548910 Maybridge4_001430 CCOC(=O)Cc1csc(NS(=O)(=O)c2cn(C)cn2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A23 mock treatment 1.98824129E8 -6180000.0 -0.08 2.00704998E8 1.26E7 0.22 0.0981 0.427 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 A24 mock treatment 2.08342164E8 3340000.0 0.04 1.99313853E8 1.12E7 0.19 0.1657 0.8412 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B01 compound treatment 1.81955403E8 -2.31E7 -0.29 1.72699965E8 -1.54E7 -0.26 -0.3905 -0.9989 3178648 Maybridge4_001431 Clc1ccc2c(Oc3ccc(NS(=O)(=O)c4ccc(s4)c5ccccn5)cn3)ncnc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B02 compound treatment 2.27477001E8 2.25E7 0.28 2.13212274E8 2.51E7 0.43 0.5037 0.9789 3178649 Maybridge4_001432 O=C(c1sc(Nc2ccc3OCCOc3c2)nc1c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B03 compound treatment 1.7589965E8 -2.91E7 -0.37 1.87756712E8 -311000.0 -0.01 -0.2619 -0.7174 1669153 Maybridge4_001433 CCc1ccc(cc1)C(=O)Nc2ccc(cc2)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B04 compound treatment 2.24531834E8 1.95E7 0.24 2.01038393E8 1.3E7 0.22 0.3302 0.9988 3178650 Maybridge4_001434 O=C(NCc1ccsc1)c2ccc3OCCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B05 compound treatment 2.21090114E8 1.61E7 0.2 2.09047798E8 2.1E7 0.36 0.3966 0.9628 3063628 Maybridge4_001435 CCc1c(nnc2cc(C)nn12)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B06 compound treatment 2.26700965E8 2.17E7 0.27 1.32802618E8 -5.53E7 -0.95 -0.4765 -0.4841 1347207 Maybridge4_001436 COc1ccc(Cn2cnc3n(C)c(=O)n(C)c(=O)c23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B07 compound treatment 2.37472317E8 3.25E7 0.41 2.03832163E8 1.58E7 0.27 0.4788 0.98 1134750 Maybridge4_001437 CC(=O)Nc1ccc(NC(=O)Nc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B08 compound treatment 2.32031198E8 2.7E7 0.34 2.16410066E8 2.83E7 0.49 0.5828 0.9846 1513237 Maybridge4_001438 CSc1c2CCCCc2c(C#N)c3nc4ccccc4n13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B09 compound treatment 2.34113686E8 2.91E7 0.37 1.38715158E8 -4.94E7 -0.84 -0.3392 -0.3685 3178651 Maybridge4_001439 Fc1ccc(cc1)S(=O)(=O)CCSc2nnc(OC(=O)c3cccs3)n2C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B10 compound treatment 2.21352111E8 1.63E7 0.21 2.13581744E8 2.55E7 0.44 0.4538 0.9406 3063629 Maybridge4_001440 N#Cc1c(/N=C/N2CCCCC2)nc3CCCCc3c1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B11 compound treatment 2.07712137E8 2710000.0 0.03 2.07961091E8 1.99E7 0.34 0.2648 0.7738 3178652 Maybridge4_001441 COC(=O)c1sccc1S(=O)(=O)N2CCN(CC2)C3c4ccccc4-c5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B12 compound treatment 2.06914055E8 1910000.0 0.02 1.97247161E8 9180000.0 0.16 0.128 0.8055 3063630 Maybridge4_001442 O=C(CN1C(=O)c2ccccc2S1(=O)=O)c3ccc4OCCCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B13 compound treatment 2.19274793E8 1.43E7 0.18 1.4350246E8 -4.46E7 -0.76 -0.4129 -0.5269 1504288 Maybridge4_001443 COc1ccc(cc1)C(=O)Nc2ccc3[nH]ccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B14 compound treatment 2.21729216E8 1.67E7 0.21 2.23321574E8 3.53E7 0.6 0.5751 0.9001 1589222 Maybridge4_001444 OC(=O)CCC(=O)NCC1COc2ccccc2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B15 compound treatment 2.19509024E8 1.45E7 0.18 2.03273792E8 1.52E7 0.26 0.3127 0.9847 1127725 Maybridge4_001445 CCOC(=O)c1nn(c2ccccc2)c3nc(Nc4ccc(C)cc4)cc(=O)n13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B16 compound treatment 2.14966058E8 9960000.0 0.12 2.08709348E8 2.06E7 0.35 0.3382 0.9024 1720808 Maybridge4_001446 O=C(CSc1ccccc1)N2c3ccccc3Sc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B17 compound treatment 2.02293339E8 -2710000.0 -0.03 1.86898923E8 -1170000.0 -0.02 -0.0382 -0.968 1598554 Maybridge4_001447 COc1ccc(cc1)C(=O)c2c(NC(=O)C)sc3CN(CCc23)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B18 compound treatment 2.15896714E8 1.09E7 0.14 2.19422023E8 3.14E7 0.54 0.4761 0.8597 3063652 Maybridge4_001448 C/C(=N\O)/C(C)(C)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B19 compound treatment 1.9107922E8 -1.39E7 -0.17 1.9029676E8 2230000.0 0.04 -0.0966 -0.54 3063653 Maybridge4_001449 Oc1nnc(SCC(=O)c2ccc(cc2)N3CCOCC3)n1C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B20 compound treatment 2.1087063E8 5870000.0 0.07 1.36436334E8 -5.16E7 -0.88 -0.5729 -0.646 3063654 Maybridge4_001450 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2ccc(COC(=O)Nc3ccccc3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B21 compound treatment 2.00647685E8 -4360000.0 -0.05 1.21364837E8 -6.67E7 -1.14 -0.846 -0.7401 3063655 Maybridge4_001451 Cc1cc2c(NC(=O)COCC(=O)O)cccc2nn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B22 compound treatment 2.16275712E8 1.13E7 0.14 2.03513852E8 1.54E7 0.26 0.2869 0.957 3178653 Maybridge4_001452 CCOC(=O)N1CCC(CC1)NC(=O)c2snnc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B23 mock treatment 2.10022533E8 5020000.0 0.06 1.99938656E8 1.19E7 0.2 0.1882 0.8847 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 B24 mock treatment 2.14972488E8 9970000.0 0.13 2.08840639E8 2.08E7 0.36 0.3398 0.9016 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C01 compound treatment 3.6951205E7 -1.68E8 -2.11 1.45027142E8 -4.3E7 -0.74 -2.0117 -0.9008 3178654 Maybridge4_001453 COc1ccc(cc1)n2ccc(nc2=S)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C02 compound treatment 6.8391226E7 -1.37E8 -1.71 1.62889902E8 -2.52E7 -0.43 -1.5166 -0.8582 1547772 Maybridge4_001454 Cc1c(cnn1c2ccc(F)cc2)C(=O)NC3CCN(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C03 compound treatment 7.7222281E7 -1.28E8 -1.6 1.59977829E8 -2.81E7 -0.48 -1.4735 -0.8805 1661624 Maybridge4_001455 Cc1ccc(cc1)C(=O)Nc2ccc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C04 compound treatment 9.7285395E7 -1.08E8 -1.35 1.71425919E8 -1.66E7 -0.28 -1.157 -0.8378 1628233 Maybridge4_001456 CCCCN1Cc2c(C1=O)n(CC(=O)c3ccc(OC)cc3)c4cc(nn4c2=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C05 compound treatment 1.45068364E8 -5.99E7 -0.75 1.74385721E8 -1.37E7 -0.23 -0.6973 -0.8854 1204335 Maybridge4_001457 O=C1N(CNc2ccccc2)C(=O)C3=C1CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C06 compound treatment 1.56486599E8 -4.85E7 -0.61 1.73450681E8 -1.46E7 -0.25 -0.6073 -0.9229 3178655 Maybridge4_001458 COc1ccccc1C2CCN(Cc3sc4ccccc4c3C)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C07 compound treatment 1.54342204E8 -5.07E7 -0.64 1.62678882E8 -2.54E7 -0.43 -0.7567 -0.9828 1326929 Maybridge4_001459 Cc1ccc(cc1C)C(=O)Nc2ccc(CN3CCS(=O)(=O)CC3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C08 compound treatment 1.51073628E8 -5.39E7 -0.68 1.6730055E8 -2.08E7 -0.36 -0.7298 -0.9549 1479015 Maybridge4_001460 O=C(Nc1ccccc1N2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C09 compound treatment 1.41099145E8 -6.39E7 -0.8 1.58937798E8 -2.91E7 -0.5 -0.9195 -0.9739 1487787 Maybridge4_001461 CCCc1cnc(nc1)N2CCN(CC2)S(=O)(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C10 compound treatment 1.42334183E8 -6.27E7 -0.79 1.64170376E8 -2.39E7 -0.41 -0.8452 -0.9537 3063656 Maybridge4_001462 Cn1cc(c(n1)C(F)(F)F)S(=O)(=O)Nc2ccccc2N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C11 compound treatment 1.40871546E8 -6.41E7 -0.8 1.66871233E8 -2.12E7 -0.36 -0.8255 -0.9353 3178656 Maybridge4_001463 COc1ccc(cc1)n2nc(cc2c3cccs3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C12 compound treatment 1.42267485E8 -6.27E7 -0.79 1.61618855E8 -2.64E7 -0.45 -0.8767 -0.9655 3063657 Maybridge4_001464 C(/N=C/1\S/C(=N/c2ccccc2)/C/3=C1/CCCC3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C13 compound treatment 1.40352429E8 -6.47E7 -0.81 1.56999578E8 -3.11E7 -0.53 -0.9496 -0.9791 1606533 Maybridge4_001465 OC(=O)CC(CC(=O)Nc1ccc(Oc2ccccc2)cc1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C14 compound treatment 1.5418454E8 -5.08E7 -0.64 1.72869094E8 -1.52E7 -0.26 -0.6348 -0.9219 3178742 Maybridge4_001466 Clc1ccc(/C=N/n2cnc3n(ncc3c2=N)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C15 compound treatment 1.57776598E8 -4.72E7 -0.59 1.73662644E8 -1.44E7 -0.25 -0.5933 -0.9245 1551950 Maybridge4_001467 CCOC(=O)c1cn(nc1N)C(=O)CCSc2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C16 compound treatment 1.5800872E8 -4.7E7 -0.59 1.62275906E8 -2.58E7 -0.44 -0.7291 -0.9898 1274385 Maybridge4_001468 CCOC(=O)C1=C(N)Oc2c(C1c3ccccc3)c(=O)oc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C17 compound treatment 1.52398803E8 -5.26E7 -0.66 1.73364817E8 -1.47E7 -0.25 -0.6446 -0.9127 1585094 Maybridge4_001469 O=S(=O)(N(CCC#N)Cc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C18 compound treatment 1.47849883E8 -5.72E7 -0.72 1.65782412E8 -2.23E7 -0.38 -0.7767 -0.9564 1144333 Maybridge4_001470 CC(C)(C)OC(=O)N1CCN(CC1)c2ccc(NS(=O)(=O)c3ccc(Cl)cc3)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C19 compound treatment 1.54891919E8 -5.01E7 -0.63 1.84023992E8 -4040000.0 -0.07 -0.4935 -0.7803 1395168 Maybridge4_001471 OC(=O)c1ccccc1C(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C20 compound treatment 1.6750206E8 -3.75E7 -0.47 1.77524746E8 -1.05E7 -0.18 -0.4603 -0.9135 3178743 Maybridge4_001472 Oc1nnc(SCC(=O)c2ccc3OCCOc3c2)n1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C21 compound treatment 1.59523681E8 -4.55E7 -0.57 1.73575011E8 -1.45E7 -0.25 -0.5789 -0.9304 1500505 Maybridge4_001473 CCOC(=O)c1cc(C)nc(N2CCC(CC2)C(=O)N)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C22 compound treatment 1.68790522E8 -3.62E7 -0.45 1.84018753E8 -4050000.0 -0.07 -0.3703 -0.8057 3178744 Maybridge4_001474 CCOC(=O)c1cnn(C(=O)c2snnc2C)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C23 mock treatment 1.81159542E8 -2.38E7 -0.3 1.6969643E8 -1.84E7 -0.31 -0.4339 -0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 C24 mock treatment 1.64906963E8 -4.01E7 -0.5 1.84110042E8 -3960000.0 -0.07 -0.4036 -0.7952 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D01 compound treatment 1.81119886E8 -2.39E7 -0.3 1.71240832E8 -1.68E7 -0.29 -0.4156 -0.9998 1160532 Maybridge4_001475 Clc1ccc2c(Oc3ccc(NC(=O)Nc4ccccc4)cn3)ncnc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D02 compound treatment 1.84975385E8 -2.0E7 -0.25 1.86440876E8 -1630000.0 -0.03 -0.1974 -0.7807 3063658 Maybridge4_001476 Oc1ccc(cc1O)C(=O)CN2C(=O)c3ccccc3S2(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D03 compound treatment 1.8333232E8 -2.17E7 -0.27 1.67810481E8 -2.03E7 -0.35 -0.4375 -0.9928 1237081 Maybridge4_001477 CN(C1CCCCC1)S(=O)(=O)c2ccc3ccccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D04 compound treatment 1.82386465E8 -2.26E7 -0.28 1.67557335E8 -2.05E7 -0.35 -0.4489 -0.9944 3063659 Maybridge4_001478 OC(CN1CCN(CC1)C2c3ccccc3-c4ccccc24)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D05 compound treatment 1.71659629E8 -3.33E7 -0.42 1.56345855E8 -3.17E7 -0.54 -0.6798 -0.9917 1413068 Maybridge4_001479 COC(=O)c1nn(c2ccccc2)c(=O)c3c(N)sc(C)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D06 compound treatment 1.72615431E8 -3.24E7 -0.41 1.55022646E8 -3.3E7 -0.57 -0.6873 -0.9868 3178745 Maybridge4_001480 C(On1nnc2ccccc12)c3ccccc3COn4nnc5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D07 compound treatment 1.80047464E8 -2.5E7 -0.31 1.72671384E8 -1.54E7 -0.26 -0.4078 -0.9963 3063660 Maybridge4_001481 CCN(C(=O)c1ccc2OCCc2c1)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D08 compound treatment 1.87874141E8 -1.71E7 -0.21 1.92336253E8 4270000.0 0.07 -0.1003 -0.4419 1525376 Maybridge4_001482 CC(=O)N(C(=O)C)c1cc(C)c(C#N)c2nc3ccccc3n12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D09 compound treatment 1.97383575E8 -7620000.0 -0.1 1.70733061E8 -1.73E7 -0.3 -0.2774 -0.8899 3063661 Maybridge4_001483 Cc1nnsc1c2nnc(SCC(=O)c3ccc(C)cc3)n2C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D10 compound treatment 1.94083062E8 -1.09E7 -0.14 1.91042842E8 2970000.0 0.05 -0.0609 -0.4165 1489082 Maybridge4_001484 Cn1c2ccccc2n3c(=O)cc(c(C#N)c13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D11 compound treatment 1.85218459E8 -1.98E7 -0.25 1.5431509E8 -3.38E7 -0.58 -0.5841 -0.9288 1735545 Maybridge4_001485 CN(CCc1ccccn1)C(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D12 compound treatment 1.77385459E8 -2.76E7 -0.35 1.70422471E8 -1.76E7 -0.3 -0.4586 -0.9977 3178746 Maybridge4_001486 Oc1ccccc1C(=O)NC(=O)c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D13 compound treatment 1.81690336E8 -2.33E7 -0.29 1.86691853E8 -1380000.0 -0.02 -0.2235 -0.7616 3178747 Maybridge4_001487 C1CCC(CC1)/N=C/2\S/C(=N\c3ccccc3)/C/4=C2/CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D14 compound treatment 1.8825607E8 -1.67E7 -0.21 1.2929487E8 -5.88E7 -1.01 -0.86 -0.8367 3063662 Maybridge4_001488 OC(=O)CCCC(=O)N1CCN(CC1)c2ncccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D15 compound treatment 1.82577823E8 -2.24E7 -0.28 1.74622516E8 -1.34E7 -0.23 -0.3617 -0.995 1539797 Maybridge4_001489 CCOC(=O)C1=NN(c2ccccc2)C3(C1c4ccc(C)cc4)C(=O)c5ccccc5C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D16 compound treatment 1.86794776E8 -1.82E7 -0.23 1.78497112E8 -9570000.0 -0.16 -0.2774 -0.9867 1582785 Maybridge4_001490 Cc1cc(C)c2c(n1)sc3c(=O)n(CC(=O)c4ccccc4)cnc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D17 compound treatment 4.20913166E8 2.16E8 2.71 4.42167317E8 2.54E8 4.35 4.9908 0.974 3178748 Maybridge4_001491 OC(=O)c1ccc(cc1)c2cn3cccnc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D18 compound treatment 1.80481457E8 -2.45E7 -0.31 1.75277392E8 -1.28E7 -0.22 -0.3724 -0.9861 3063663 Maybridge4_001492 C/C(=N\O)/C(C)(C)Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D19 compound treatment 1.78858973E8 -2.61E7 -0.33 1.6564057E8 -2.24E7 -0.38 -0.5034 -0.9969 1236138 Maybridge4_001493 Cc1nc(Nc2ccccc2)sc1C(=O)c3cc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D20 compound treatment 1.80681575E8 -2.43E7 -0.31 1.82803692E8 -5260000.0 -0.09 -0.2795 -0.8784 3063664 Maybridge4_001494 FC(F)(F)c1ccccc1NS(=O)(=O)c2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D21 compound treatment 1.89060396E8 -1.59E7 -0.2 1.78393525E8 -9670000.0 -0.17 -0.2585 -0.9956 3178749 Maybridge4_001495 O=C(NCCN1CCNC1=O)c2ccc3nccnc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D22 compound treatment 1.81323419E8 -2.37E7 -0.3 1.81356322E8 -6710000.0 -0.11 -0.2913 -0.9146 3178750 Maybridge4_001496 Cc1nc(cs1)c2ccc(s2)S(=O)(=O)N3CCCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D23 mock treatment 1.72699057E8 -3.23E7 -0.41 1.69547843E8 -1.85E7 -0.32 -0.5107 -0.9926 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 D24 mock treatment 1.6546024E8 -3.95E7 -0.5 1.66989274E8 -2.11E7 -0.36 -0.6059 -0.9878 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E01 compound treatment 7.8308157E7 -1.27E8 -1.59 2.14933673E8 2.69E7 0.46 -0.7987 -0.4827 3063665 Maybridge4_001497 Cc1ccc(cc1)c2ccn(c3ccc(C)c(Cl)c3)c(=S)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E02 compound treatment 1.35945415E8 -6.91E7 -0.87 2.07965173E8 1.99E7 0.34 -0.3717 -0.3994 1172555 Maybridge4_001498 O=C(Nc1ccc(cc1)c2cn3CCSc3n2)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E03 compound treatment 1.31312898E8 -7.37E7 -0.92 2.30662753E8 4.26E7 0.73 -0.1381 -0.1173 1326393 Maybridge4_001499 OC(=O)c1ccccc1C(=O)N2CCN(Cc3ccncc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E04 compound treatment 1.71596531E8 -3.34E7 -0.42 2.27937534E8 3.99E7 0.68 0.1862 0.2325 1616068 Maybridge4_001500 Clc1ccccc1N2CCN(CC2)C3=Cc4ccccc4CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E05 compound treatment 2.26727769E8 2.17E7 0.27 2.27775058E8 3.97E7 0.68 0.6733 0.9195 1429251 Maybridge4_001501 O=C(NC1CCCc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E06 compound treatment 2.27741838E8 2.27E7 0.29 2.35151567E8 4.71E7 0.81 0.7716 0.9025 1274546 Maybridge4_001502 Cc1c(CN2CCc3ccccc3C2)sc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E07 compound treatment 2.33073758E8 2.81E7 0.35 2.39080109E8 5.1E7 0.87 0.8664 0.9202 1237910 Maybridge4_001503 O=C(Nc1ccc(CN2CCS(=O)(=O)CC2)cc1)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E08 compound treatment 2.36523784E8 3.15E7 0.4 2.20685487E8 3.26E7 0.56 0.6744 0.9857 1710600 Maybridge4_001504 Cn1cnc(c1)S(=O)(=O)Nc2ccccc2N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E09 compound treatment 2.20707329E8 1.57E7 0.2 2.26153419E8 3.81E7 0.65 0.6003 0.8814 1424693 Maybridge4_001505 Cc1ccc(NC(=O)N(CCC(=O)O)Cc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E10 compound treatment 2.20976131E8 1.6E7 0.2 2.22517603E8 3.44E7 0.59 0.5586 0.897 1251028 Maybridge4_001506 CC(C)(C)c1cn2cccc(OCc3ccc(Cl)c(Cl)c3)c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E11 compound treatment 2.36042103E8 3.1E7 0.39 2.35617077E8 4.75E7 0.81 0.8508 0.943 1143941 Maybridge4_001507 O=S(=O)(NC1CCCc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E12 compound treatment 2.83428376E8 7.84E7 0.98 2.48756663E8 6.07E7 1.04 1.4302 0.9996 3178751 Maybridge4_001508 Nc1c(cnn1c2ccccc2)c3n[nH]c(=S)n3c4ccc(Cl)cc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E13 compound treatment 2.56554435E8 5.15E7 0.65 2.43600717E8 5.55E7 0.95 1.1294 0.9824 3063666 Maybridge4_001509 FC(F)(F)c1ccn(n1)c2ccc(NC(=O)Nc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E14 compound treatment 2.66256884E8 6.13E7 0.77 2.58656315E8 7.06E7 1.21 1.3977 0.9761 3178752 Maybridge4_001510 CCOC(=O)COc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E15 compound treatment 2.8587948E8 8.09E7 1.01 2.62824658E8 7.48E7 1.28 1.6222 0.9934 1607723 Maybridge4_001511 CCOC(=O)c1cnn(C(=O)c2c(C)nc3ccccn23)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E16 compound treatment 2.60691447E8 5.57E7 0.7 2.39938231E8 5.19E7 0.89 1.1218 0.993 1572679 Maybridge4_001512 Cc1nn(c2ccccc2)c3[nH]c(=O)c(C#N)c(c4cccs4)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E17 compound treatment 2.59323546E8 5.43E7 0.68 2.37381996E8 4.93E7 0.84 1.0787 0.9944 1609957 Maybridge4_001513 O=S(=O)(N(CCC#N)CCc1ccccn1)c2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E18 compound treatment 2.54892029E8 4.99E7 0.63 2.59925425E8 7.19E7 1.23 1.3123 0.9509 1377637 Maybridge4_001514 S=C(Nc1ccc2OCCOc2c1)Nc3ccccc3N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E19 compound treatment 2.48766078E8 4.38E7 0.55 2.43757499E8 5.57E7 0.95 1.0622 0.9656 1175800 Maybridge4_001515 OC(=O)CCC(=O)NC1CCCCNC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E20 compound treatment 2.49785145E8 4.48E7 0.56 2.31195173E8 4.31E7 0.74 0.9192 0.9909 1593716 Maybridge4_001516 CC(c1ccccc1)n2c(O)nnc2SCc3cc(=O)oc4cc(O)ccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E21 compound treatment 2.98170113E8 9.32E7 1.17 2.4384071E8 5.58E7 0.95 1.5015 0.995 1417192 Maybridge4_001517 CCOC(=O)C1CCN(CC1)C(=O)c2ccc(CC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E22 compound treatment 2.5954891E8 5.45E7 0.68 2.364147E8 4.83E7 0.83 1.069 0.9955 3063667 Maybridge4_001518 Cc1nnsc1c2nnc(SCC(=O)N(C3CCCCC3)c4ccccc4)n2C5CC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E23 mock treatment 2.50306715E8 4.53E7 0.57 2.27067637E8 3.9E7 0.67 0.8739 0.9968 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 E24 mock treatment 2.4060267E8 3.56E7 0.45 2.28119166E8 4.01E7 0.69 0.8005 0.9784 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F01 compound treatment 2.51475115E8 4.65E7 0.58 2.25129399E8 3.71E7 0.63 0.8608 0.9991 1399434 Maybridge4_001519 Cc1ccc(cc1)C(O)COC2=NCNc3cc(Cl)ccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F02 compound treatment 2.24858006E8 1.99E7 0.25 1.94792573E8 6720000.0 0.12 0.2575 0.9385 3063693 Maybridge4_001520 Clc1ccc(c(Cl)c1)S(=O)(=O)CCN2C(=O)c3ccccc3S2(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F03 compound treatment 2.46863298E8 4.19E7 0.53 2.29453687E8 4.14E7 0.71 0.8722 0.9891 1228123 Maybridge4_001521 COC(=O)c1cc(oc1C)S(=O)(=O)N(C)C2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F04 compound treatment 2.78047549E8 7.3E7 0.92 2.3092474E8 4.29E7 0.73 1.1667 0.9939 3063694 Maybridge4_001522 Cc1nc(sc1c2nnc(o2)c3cccc4ccccc34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F05 compound treatment 2.54697729E8 4.97E7 0.62 2.34216405E8 4.61E7 0.79 0.9994 0.9931 1500694 Maybridge4_001523 CC(=O)Nc1cc(nn(c2ccccc2)c1=O)C(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F06 compound treatment 2.42001349E8 3.7E7 0.46 2.29251077E8 4.12E7 0.7 0.8267 0.9794 3063695 Maybridge4_001524 S=c1[nH]nc(c2ccncc2)n1/N=C/c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F07 compound treatment 2.84683837E8 7.97E7 1.0 2.41487594E8 5.34E7 0.91 1.3534 0.999 1217417 Maybridge4_001525 CCOC(=O)c1cc2cc(OCc3ccccc3)ccc2n1C(=O)c4ccccc4C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F08 compound treatment 2.61390016E8 5.64E7 0.71 2.38114564E8 5.0E7 0.86 1.1059 0.9955 1688932 Maybridge4_001526 NNC(=O)Cn1nc(c2ccccc2)c(c(C#N)c1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F09 compound treatment 2.72387406E8 6.74E7 0.85 2.42172747E8 5.41E7 0.93 1.2526 0.999 3178837 Maybridge4_001527 CCc1cc(C(=O)c2ccc(OC)cc2)c(NC(=O)c3ccc(cc3)C(F)(F)F)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F10 compound treatment 2.42711355E8 3.77E7 0.47 2.2189428E8 3.38E7 0.58 0.7439 0.995 1686628 Maybridge4_001528 NNC(=O)c1oc2nc(cc(c3ccccc3)c2c1N)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F11 compound treatment 2.93350081E8 8.83E7 1.11 2.35021187E8 4.7E7 0.8 1.352 0.9876 1119276 Maybridge4_001529 CN(CCc1ccccn1)C(=O)NS(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F12 compound treatment 2.81760621E8 7.68E7 0.96 2.51717032E8 6.36E7 1.09 1.4513 0.9981 3063696 Maybridge4_001530 Fc1ccc(cc1)C(=O)CN2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F13 compound treatment 2.42328994E8 3.73E7 0.47 2.1023973E8 2.22E7 0.38 0.5994 0.9946 1398696 Maybridge4_001531 Cn1c(SCc2n[nH]c(=S)n2CC=C)nnc1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F14 compound treatment 2.87458506E8 8.25E7 1.03 2.60853567E8 7.28E7 1.25 1.6124 0.9957 3063697 Maybridge4_001532 OC(=O)c1ccccc1C(=O)N2CCN(CC2)c3ncccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F15 compound treatment 2.47791742E8 4.28E7 0.54 2.41525027E8 5.35E7 0.92 1.0266 0.9677 3178838 Maybridge4_001533 Fc1ccc(cc1)C(=O)COc2nnc(SCCS(=O)(=O)c3ccc(F)cc3)n2C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F16 compound treatment 1.89347415E8 -1.57E7 -0.2 1.73241634E8 -1.48E7 -0.25 -0.3184 -0.992 3063698 Maybridge4_001534 O=C/1N(Cc2ccccc2)c3ccccc3\C1=N\c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F17 compound treatment 2.39324191E8 3.43E7 0.43 1.68740697E8 -1.93E7 -0.33 0.0705 0.1298 3178839 Maybridge4_001535 CCOC(=O)C1=NN(C(=C2C(=O)c3ccccc3C2=O)C1c4cccs4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F18 compound treatment 2.55962544E8 5.1E7 0.64 1.91085766E8 3020000.0 0.05 0.4885 0.7618 3063699 Maybridge4_001536 COc1ccc(cc1OC)C(=O)NC(=O)c2ccccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F19 compound treatment 2.49437386E8 4.44E7 0.56 2.42307686E8 5.42E7 0.93 1.0507 0.9702 1600649 Maybridge4_001537 O=C(N1CCOCC1)c2ccc3OCCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F20 compound treatment 2.46929266E8 4.19E7 0.53 2.47475754E8 5.94E7 1.02 1.091 0.9529 3063700 Maybridge4_001538 CCN(c1cccc2ccccc12)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F21 compound treatment 2.51167689E8 4.62E7 0.58 2.44556506E8 5.65E7 0.97 1.0932 0.9699 3178840 Maybridge4_001539 O=C(NCCc1ccccn1)c2ccc3nccnc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F22 compound treatment 2.46109992E8 4.11E7 0.52 1.57304351E8 -3.08E7 -0.53 -0.0078 -0.0105 3178841 Maybridge4_001540 CC(C)(C)OC(=O)N1CCCN(CC1)C(=O)c2cccnc2Oc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F23 mock treatment 2.5053246E8 4.55E7 0.57 2.23104732E8 3.5E7 0.6 0.8279 0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 F24 mock treatment 2.42114458E8 3.71E7 0.47 2.04958986E8 1.69E7 0.29 0.5336 0.9738 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G01 compound treatment 3.434532E7 -1.71E8 -2.14 1.74264617E8 -1.38E7 -0.24 -1.6809 -0.7804 3063701 Maybridge4_001541 COc1ccc(cc1n2ccc(nc2=S)c3ccc(C)cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G02 compound treatment 8.1076875E7 -1.24E8 -1.55 2.04462982E8 1.64E7 0.28 -0.9008 -0.5702 1377005 Maybridge4_001542 Cc1ccc(cc1C)C(=O)Nc2ccc(cc2)c3cn4CCSc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G03 compound treatment 8.1631184E7 -1.23E8 -1.55 2.1385854E8 2.58E7 0.44 -0.7822 -0.486 1733649 Maybridge4_001543 CC(C)c1ccc(NC(=O)CSCc2csc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G04 compound treatment 1.5043511E8 -5.46E7 -0.68 2.31107857E8 4.3E7 0.74 0.0369 0.0367 1177034 Maybridge4_001544 Cc1ccc(cc1)n2nnnc2c3c[nH]c4cc(Cl)c(F)cc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G05 compound treatment 2.13183333E8 8180000.0 0.1 2.32185635E8 4.41E7 0.76 0.6065 0.7959 3178842 Maybridge4_001545 Clc1ccc2OCC(=Cc2c1)C(=O)NC3CCCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G06 compound treatment 2.29906452E8 2.49E7 0.31 2.24638358E8 3.66E7 0.63 0.6635 0.9484 1406389 Maybridge4_001546 CCCCc1ccc(NC(=O)Nc2ccc(cc2)N3CCCCC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G07 compound treatment 2.27459049E8 2.25E7 0.28 2.38973275E8 5.09E7 0.87 0.8153 0.8903 1501125 Maybridge4_001547 Cc1nnsc1C(=O)Nc2ccc(CN3CCS(=O)(=O)CC3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G08 compound treatment 2.25464996E8 2.05E7 0.26 2.35680113E8 4.76E7 0.82 0.7578 0.8868 3063702 Maybridge4_001548 CCN(CC)S(=O)(=O)c1ccc(cc1)c2cc(sc2C(F)(F)F)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G09 compound treatment 2.34943083E8 2.99E7 0.38 2.24627248E8 3.66E7 0.63 0.7081 0.9702 1046775 Maybridge4_001549 O=C1CCN(Cc2ccccc2)C(=O)N1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G10 compound treatment 2.09406633E8 4400000.0 0.06 1.99643593E8 1.16E7 0.2 0.1792 0.8709 1245508 Maybridge4_001550 Clc1ccc(Cl)c(NC(=O)CC2N(CCNC2=O)C(=O)Nc3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G11 compound treatment 2.29990194E8 2.5E7 0.31 2.28212862E8 4.01E7 0.69 0.7075 0.9368 3063703 Maybridge4_001551 COc1ccc(OCC2CN=C(Nc3ccc(C)cc3)S2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G12 compound treatment 2.51119267E8 4.61E7 0.58 2.55107336E8 6.7E7 1.15 1.2205 0.9497 3178843 Maybridge4_001552 Clc1ccc(/C=N/n2cnc3n(ncc3c2=O)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G13 compound treatment 2.39911582E8 3.49E7 0.44 2.3636982E8 4.83E7 0.83 0.8943 0.9558 3063704 Maybridge4_001553 CC(C)N(CCC#N)C(=O)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G14 compound treatment 2.38231447E8 3.32E7 0.42 2.24207649E8 3.61E7 0.62 0.7322 0.9815 1165894 Maybridge4_001554 Cn1c(SCC=C)nnc1c2oc3nc(cc(c4ccccc4)c3c2N)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G15 compound treatment 2.25530094E8 2.05E7 0.26 2.13008714E8 2.49E7 0.43 0.4839 0.9707 3063705 Maybridge4_001555 Cc1ccc(cc1)C(O)CSc2nnc(c3ccc4ccccc4c3)n2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G16 compound treatment 2.6552735E8 6.05E7 0.76 2.36713391E8 4.86E7 0.83 1.1257 0.9989 3178844 Maybridge4_001556 CC1CCc2c(C1)sc3ncn(CC=C)c(=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G17 compound treatment 2.63584964E8 5.86E7 0.73 2.35206673E8 4.71E7 0.81 1.0902 0.9989 1415511 Maybridge4_001557 CC(C)c1ccc(NC(=O)COc2ncnc3cc(Cl)ccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G18 compound treatment 2.61166929E8 5.62E7 0.7 2.33830575E8 4.58E7 0.78 1.0521 0.9986 3063706 Maybridge4_001558 CN(C1CCCCC1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G19 compound treatment 2.39499696E8 3.45E7 0.43 2.14554309E8 2.65E7 0.45 0.6266 0.9997 1222950 Maybridge4_001559 COc1ccc(Cc2nnc(SCC3CC3)n2c4ccc(F)cc4)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G20 compound treatment 2.57684497E8 5.27E7 0.66 2.10263889E8 2.22E7 0.38 0.7359 0.9655 3063707 Maybridge4_001560 Oc1nnc(SCc2cc(=O)oc3cc(O)ccc23)n1Cc4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G21 compound treatment 2.6526666E8 6.03E7 0.76 2.28113396E8 4.0E7 0.69 1.0193 0.9988 1138850 Maybridge4_001561 CCOC(=O)C1CCN(CC1)C(=O)C2Cc3ccccc3N2C(=O)OCc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G22 compound treatment 2.6335226E8 5.83E7 0.73 2.20751027E8 3.27E7 0.56 0.9132 0.9912 3063708 Maybridge4_001562 O=S(=O)(Nc1ccccc1C#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G23 mock treatment 2.63414592E8 5.84E7 0.73 2.23206654E8 3.51E7 0.6 0.9434 0.9952 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 G24 mock treatment 2.44810272E8 3.98E7 0.5 2.18161468E8 3.01E7 0.52 0.7173 0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H01 compound treatment 2.3516713E8 3.02E7 0.38 2.19891777E8 3.18E7 0.54 0.6527 0.9841 3178845 Maybridge4_001563 Oc1nnc(SCCS(=O)(=O)c2ccc(F)cc2)n1Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H02 compound treatment 2.47261409E8 4.23E7 0.53 2.25299526E8 3.72E7 0.64 0.8255 0.9958 3063709 Maybridge4_001564 Cc1noc(C)c1c2nc(CN3C(=O)c4ccccc4S3(=O)=O)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H03 compound treatment 2.47118746E8 4.21E7 0.53 2.37966579E8 4.99E7 0.85 0.9775 0.9733 3178846 Maybridge4_001565 OC(=O)COCC(=O)Nc1ccc(Oc2cccc(c2)C(F)(F)F)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H04 compound treatment 2.27592044E8 2.26E7 0.28 2.23156447E8 3.51E7 0.6 0.6251 0.9412 1968939 Maybridge4_001566 CC(C)(CC(=O)O)CC(=O)N1CCN(CC1)C2c3ccccc3-c4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H05 compound treatment 2.27749022E8 2.27E7 0.29 2.15669234E8 2.76E7 0.47 0.5358 0.9708 3178847 Maybridge4_001567 COC(=O)C1N(N=C(C=C1C(=O)OC)C(=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H06 compound treatment 2.4271208E8 3.77E7 0.47 2.31556734E8 4.35E7 0.74 0.8609 0.976 1661945 Maybridge4_001568 Clc1cccc(NC(=O)N2CCCn3c(SCC=C)nnc23)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H07 compound treatment 2.41868687E8 3.69E7 0.46 2.37758502E8 4.97E7 0.85 0.9285 0.959 3178848 Maybridge4_001569 Oc1nnc(SCC(=O)Nc2ccccc2)n1Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H08 compound treatment 2.65669357E8 6.07E7 0.76 2.394729E8 5.14E7 0.88 1.1603 0.9974 1169532 Maybridge4_001570 NNC(=O)CN1c2ccccc2Sc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H09 compound treatment 2.48144579E8 4.31E7 0.54 2.3033111E8 4.23E7 0.72 0.8942 0.9898 3178849 Maybridge4_001571 Clc1cc(Cl)cc(Oc2ccc(o2)C(=O)NC3Cc4ccccc4C3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H10 compound treatment 2.43193021E8 3.82E7 0.48 2.30255126E8 4.22E7 0.72 0.8494 0.9801 3063710 Maybridge4_001572 N#Cc1sc2nc3ccccc3n2c1/N=C/c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H11 compound treatment 2.27536017E8 2.25E7 0.28 2.10530761E8 2.25E7 0.38 0.4717 0.9885 1394169 Maybridge4_001573 O=C(Nc1ccc(OCc2ccccc2)cc1)N3CCN(CC3)C(=O)C4COc5ccccc5O4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H12 compound treatment 2.37223415E8 3.22E7 0.4 2.42543076E8 5.45E7 0.93 0.9452 0.93 3063711 Maybridge4_001574 O=C1Nc2ccccc2C1Cc3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H13 compound treatment 2.47739669E8 4.27E7 0.54 2.32882758E8 4.48E7 0.77 0.9215 0.9846 1163008 Maybridge4_001575 S=C(Nc1ccccc1)C(C#N)c2nc3ccccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H14 compound treatment 2.59647207E8 5.46E7 0.69 2.13950784E8 2.59E7 0.44 0.798 0.9777 3063712 Maybridge4_001576 NS(=O)(=O)c1ccc(cc1)N(S(=O)(=O)c2ccccc2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H15 compound treatment 2.56228368E8 5.12E7 0.64 2.20547297E8 3.25E7 0.56 0.8475 0.9974 3178934 Maybridge4_001577 CC(C)(C)c1ccc(cc1)c2noc(CSc3nnc(O)n3c4cccnc4)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H16 compound treatment 2.51147807E8 4.61E7 0.58 2.24460237E8 3.64E7 0.62 0.8498 0.9993 1688554 Maybridge4_001578 CCNc1nc(SCC(=O)OCC)nc2sc3CC(C)CCc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H17 compound treatment 2.62571245E8 5.76E7 0.72 2.38806814E8 5.07E7 0.87 1.1248 0.9958 1408340 Maybridge4_001579 O=C1c2ccccc2-c3c1cnc4c(cnn34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H18 compound treatment 2.70402594E8 6.54E7 0.82 2.34994202E8 4.69E7 0.8 1.1481 0.9999 3063713 Maybridge4_001580 O=C(NCC1CC1)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H19 compound treatment 2.59452536E8 5.44E7 0.68 2.35398602E8 4.73E7 0.81 1.0559 0.9964 1279297 Maybridge4_001581 Cc1ccc(Oc2ncccc2NC(=O)Nc3ccccc3)c4CCCc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H20 compound treatment 2.46620912E8 4.16E7 0.52 1.98881115E8 1.08E7 0.19 0.5 0.9028 3178935 Maybridge4_001582 Cn1cnc(c1)S(=O)(=O)N(Cc2ccccc2)Cc3ccccc3N4CCC(CC4)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H21 compound treatment 2.58036445E8 5.3E7 0.67 2.31983182E8 4.39E7 0.75 1.002 0.9981 3063714 Maybridge4_001583 CC(c1ccccc1)n2c(O)nnc2SCC(=O)c3csc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H22 compound treatment 2.57644248E8 5.26E7 0.66 2.24619753E8 3.66E7 0.63 0.9094 0.9996 3178936 Maybridge4_001584 C1C(=Nc2ccccc2N=C1c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H23 mock treatment 2.66502039E8 6.15E7 0.77 2.21159737E8 3.31E7 0.57 0.946 0.9885 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 H24 mock treatment 2.56412989E8 5.14E7 0.64 2.14008157E8 2.59E7 0.44 0.77 0.9834 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I01 compound treatment 3.2988232E7 -1.72E8 -2.16 2.00025993E8 1.2E7 0.2 -1.3811 -0.6372 3063715 Maybridge4_001585 Fc1ccc(cc1)c2oncc2c3nnnn3c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I02 compound treatment 4.1639524E7 -1.63E8 -2.05 2.24753588E8 3.67E7 0.63 -1.0051 -0.4689 1145291 Maybridge4_001586 O=C(Nc1ccc(cc1)c2cn3CCSc3n2)c4ccc5nonc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I03 compound treatment 4.0047308E7 -1.65E8 -2.07 2.03089029E8 1.5E7 0.26 -1.2814 -0.6145 1583736 Maybridge4_001587 Cc1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I04 compound treatment 4.1950307E7 -1.63E8 -2.05 1.76324753E8 -1.17E7 -0.2 -1.5885 -0.7729 1281751 Maybridge4_001588 CN(CC(=O)O)c1ncc(c2nnnn2c3ccccc3)c(n1)c4ccccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I05 compound treatment 1.27373942E8 -7.76E7 -0.97 2.46515737E8 5.84E7 1.0 0.0188 0.0135 3178937 Maybridge4_001589 Cc1nc(ccc1C(=O)Oc2ccccc2N3CCCCC3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I06 compound treatment 1.51854406E8 -5.32E7 -0.67 2.48941515E8 6.09E7 1.04 0.2654 0.2145 1529830 Maybridge4_001590 Clc1cccc(NC(=O)Nc2ccc(cc2)N3CCCCC3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I07 compound treatment 1.73238691E8 -3.18E7 -0.4 2.728998E8 8.48E7 1.45 0.745 0.4948 1741796 Maybridge4_001591 Cc1cc(no1)C(=O)Nc2ccc(CN3CCS(=O)(=O)CC3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I08 compound treatment 1.78473021E8 -2.65E7 -0.33 2.5394927E8 6.59E7 1.13 0.5621 0.478 1155868 Maybridge4_001592 CC(C)N(Cc1ccccc1)S(=O)(=O)c2ccc3ccccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I09 compound treatment 1.6207116E8 -4.29E7 -0.54 2.33547656E8 4.55E7 0.78 0.1697 0.1792 1382929 Maybridge4_001593 COc1ccc(cc1)C(=O)N2CCc3cc(OC)c(OC)cc3C2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I10 compound treatment 1.83728631E8 -2.13E7 -0.27 2.26030776E8 3.8E7 0.65 0.2708 0.3854 3178938 Maybridge4_001594 CC(C)(C)c1cc(NC(=O)Nc2ccccc2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I11 compound treatment 1.92488471E8 -1.25E7 -0.16 2.49844337E8 6.18E7 1.06 0.6367 0.5956 3063716 Maybridge4_001595 Cc1nc(ccc1C(=O)NCC(O)c2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I12 compound treatment 1.8717794E8 -1.78E7 -0.22 2.17395427E8 2.93E7 0.5 0.1968 0.3582 3178939 Maybridge4_001596 Cn1c(CSc2nnc(c3ccccc3)n2CC=C)nnc1SCc4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I13 compound treatment 1.88078651E8 -1.69E7 -0.21 2.25274337E8 3.72E7 0.64 0.3002 0.4472 3063717 Maybridge4_001597 CC(C)N1CCC(=O)N(C1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I14 compound treatment 1.81474728E8 -2.35E7 -0.3 2.47916051E8 5.98E7 1.02 0.5157 0.4837 1303953 Maybridge4_001598 O=c1[nH]cnc2n(c3ccccc3)c(=S)sc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I15 compound treatment 2.13489403E8 8480000.0 0.11 2.36486348E8 4.84E7 0.83 0.6613 0.7914 1733519 Maybridge4_001599 Cc1nc2ccccn2c1c3ccnc(SCC(=O)N(C4CCCCC4)c5ccccc5)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I16 compound treatment 2.27744708E8 2.27E7 0.29 2.73048157E8 8.5E7 1.45 1.2303 0.83 1465542 Maybridge4_001600 Cc1ccc(cc1)C(=O)CN(Cc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I17 compound treatment 2.24153491E8 1.91E7 0.24 2.68959059E8 8.09E7 1.38 1.149 0.8176 3063736 Maybridge4_001601 OC(=O)CC(CC(=O)Oc1ccccc1N2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I18 compound treatment 2.16261978E8 1.13E7 0.14 2.2942841E8 4.14E7 0.71 0.6005 0.8318 3063737 Maybridge4_001602 CC(C)N(Cc1ccccc1)C(=O)Nc2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I19 compound treatment 2.03883494E8 -1120000.0 -0.01 2.31750735E8 4.37E7 0.75 0.5188 0.6937 1622159 Maybridge4_001603 COc1ccc(Cc2nnc(SCC(=O)NC(C)C)n2c3ccc(F)cc3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I20 compound treatment 2.0413234E8 -873000.0 -0.01 2.26640171E8 3.86E7 0.66 0.4591 0.6953 3063738 Maybridge4_001604 Cc1cc(C)c(c(C)c1)n2c(O)nnc2SCCS(=O)(=O)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I21 compound treatment 2.31060434E8 2.61E7 0.33 2.69651949E8 8.16E7 1.4 1.2186 0.8496 1522253 Maybridge4_001605 CCOC(=O)C1CCN(CC1)C(=O)c2sc(nc2C)c3ccc4OCCc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I22 compound treatment 2.33059099E8 2.81E7 0.35 2.26247395E8 3.82E7 0.65 0.711 0.9578 3063739 Maybridge4_001606 O=S(=O)(Nc1ccccc1N2CCCCC2)c3cccc4nonc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I23 mock treatment 2.41355699E8 3.64E7 0.46 2.19770606E8 3.17E7 0.54 0.7062 0.9963 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 I24 mock treatment 2.39062031E8 3.41E7 0.43 2.27657003E8 3.96E7 0.68 0.7813 0.9753 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J01 compound treatment 2.14559949E8 9550000.0 0.12 1.94591707E8 6520000.0 0.11 0.1637 0.9994 1381618 Maybridge4_001607 CC(C)c1ccc(NC(=O)CSc2nnc(O)n2C(C)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J02 compound treatment 2.21634758E8 1.66E7 0.21 2.45256692E8 5.72E7 0.98 0.8397 0.8389 3063740 Maybridge4_001608 Cc1onc(c1CN2C(=O)c3ccccc3S2(=O)=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J03 compound treatment 2.56873082E8 5.19E7 0.65 2.40078852E8 5.2E7 0.89 1.0896 0.9881 1310898 Maybridge4_001609 Clc1cccc(NC(=O)Nc2ccccc2N3CCCCC3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J04 compound treatment 2.57356061E8 5.24E7 0.66 2.4690195E8 5.88E7 1.01 1.1765 0.9785 1473794 Maybridge4_001610 Fc1cn(Cc2c(Cl)cccc2Cl)c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J05 compound treatment 2.53348001E8 4.83E7 0.61 2.55018826E8 6.7E7 1.15 1.2392 0.9557 1148553 Maybridge4_001611 CCOC(=O)c1nn(c2ccccc2)c(=O)c3c(N)c(C#N)c(cc13)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J06 compound treatment 1.85968181E8 -1.9E7 -0.24 1.77093279E8 -1.1E7 -0.19 -0.3017 -0.9929 2101411 Maybridge4_001612 O=C(Oc1c(C#N)sc2n(c3ccccc3)c(=S)n(c4ccccc4)c(=O)c12)c5cccs5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J07 compound treatment 2.23579855E8 1.86E7 0.23 1.88597562E8 529000.0 0.01 0.1712 0.7341 1624521 Maybridge4_001613 CC(c1ccccc1)n2c(OC(=O)N(C)C)nnc2SCC(=O)c3ccc4OCCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J08 compound treatment 2.38971027E8 3.4E7 0.43 2.35177152E8 4.71E7 0.81 0.8715 0.9555 3063741 Maybridge4_001614 CCOC(=O)c1cnn(c1NC(=O)Nc2cccc(Cl)c2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J09 compound treatment 2.73741622E8 6.87E7 0.86 2.53411926E8 6.53E7 1.12 1.4006 0.9917 3063742 Maybridge4_001615 Cc1cc(C)cc(OC(=O)c2ccc(Oc3cc(Cl)cc(Cl)c3)o2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J10 compound treatment 2.61585124E8 5.66E7 0.71 2.44347074E8 5.63E7 0.96 1.1831 0.9887 1606613 Maybridge4_001616 COc1cc(OC)c2nc(C)c3CN(Cc3c2c1)C(=O)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J11 compound treatment 2.81654566E8 7.66E7 0.96 2.57894262E8 6.98E7 1.2 1.5251 0.9942 3178940 Maybridge4_001617 CN(C(=O)c1nn(nc1C)c2ccccc2)c3nnc(s3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J12 compound treatment 2.51091415E8 4.61E7 0.58 2.51524653E8 6.35E7 1.09 1.1769 0.9564 3063743 Maybridge4_001618 Cc1sc(nc1c2ccccc2)c3ccc(cc3)c4csnn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J13 compound treatment 2.57618505E8 5.26E7 0.66 2.89301621E8 1.01E8 1.73 1.692 0.9125 3178941 Maybridge4_001619 S=c1[nH]nc(CCCCc2n[nH]c(=S)[nH]2)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J14 compound treatment 2.51999128E8 4.7E7 0.59 2.43811373E8 5.57E7 0.95 1.0916 0.9732 3063744 Maybridge4_001620 O=C(Nc1ccccc1N2CCOCC2)C3=NNC(=O)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J15 compound treatment 2.71453841E8 6.64E7 0.83 2.64939821E8 7.69E7 1.32 1.5199 0.9757 3178942 Maybridge4_001621 Cc1c(sc2ccc(Cl)cc12)C(=O)CSc3nnc(O)n3C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J16 compound treatment 2.49123702E8 4.41E7 0.55 2.29461381E8 4.14E7 0.71 0.8924 0.9925 1671368 Maybridge4_001622 O=C(CSc1nnc(o1)c2ccncc2)N3c4ccccc4Sc5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J17 compound treatment 2.54388417E8 4.94E7 0.62 2.5873161E8 7.07E7 1.21 1.2934 0.9517 3178943 Maybridge4_001623 CC(C)(C)c1cc(N/C=C/C(=O)c2ccc(Cl)cc2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J18 compound treatment 2.57937203E8 5.29E7 0.66 2.56111974E8 6.8E7 1.16 1.2931 0.9645 3178944 Maybridge4_001624 O=C(C1=NOC2(C1c3ccccc3)C(=O)c4ccccc4C2=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J19 compound treatment 2.24923823E8 1.99E7 0.25 2.09737353E8 2.17E7 0.37 0.439 0.9815 1576744 Maybridge4_001625 Cc1ccc(Oc2ncccc2NC(=O)CC(CC(=O)O)c3ccccc3)c4CCCc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J20 compound treatment 2.5746864E8 5.25E7 0.66 2.53101694E8 6.5E7 1.11 1.2525 0.9685 1506454 Maybridge4_001626 CCOC(=O)N1CCC(CC1)NS(=O)(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J21 compound treatment 2.41363641E8 3.64E7 0.46 1.94498044E8 6430000.0 0.11 0.4003 0.8533 3178945 Maybridge4_001627 Cc1cc(C)c(c(C)c1)n2c(O)nnc2SCC(=O)c3ccc(C#N)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J22 compound treatment 2.38686283E8 3.37E7 0.42 2.43442145E8 5.54E7 0.95 0.969 0.9337 3063745 Maybridge4_001628 OC(=O)CSCC(=O)Nc1n[nH]c(SCc2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J23 mock treatment 2.43720958E8 3.87E7 0.49 2.32434084E8 4.44E7 0.76 0.8804 0.9767 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 J24 mock treatment 2.22950658E8 1.79E7 0.23 2.23346806E8 3.53E7 0.6 0.5862 0.9096 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K01 compound treatment 3.0962479E7 -1.74E8 -2.18 6.2548129E7 -1.26E8 -2.15 -3.0631 -1.0 3178946 Maybridge4_001629 Cc1ccccc1c2oncc2c3nnnn3c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K02 compound treatment 3.8161466E7 -1.67E8 -2.09 1.03205957E8 -8.49E7 -1.45 -2.5072 -0.9841 1125361 Maybridge4_001630 COC(=O)c1sccc1S(=O)(=O)Nc2ccc(cc2)c3cn4CCSc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K03 compound treatment 4.0844034E7 -1.64E8 -2.06 1.17194584E8 -7.09E7 -1.21 -2.314 -0.9682 1429606 Maybridge4_001631 CC(C)(C)c1ccc(NC(=O)NC2CCCc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K04 compound treatment 5.1537914E7 -1.53E8 -1.93 1.39619665E8 -4.84E7 -0.83 -1.9477 -0.9292 1237562 Maybridge4_001632 CCOC(=O)C1CCCN(C1)C(=O)S(=O)(=O)c2ccc(s2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K05 compound treatment 1.27720715E8 -7.73E7 -0.97 1.72217737E8 -1.59E7 -0.27 -0.8774 -0.8715 3063746 Maybridge4_001633 Cc1ccc(cc1)S(=O)(=O)NC(=O)Oc2ccccc2N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K06 compound treatment 1.45059211E8 -5.99E7 -0.75 1.6629941E8 -2.18E7 -0.37 -0.7952 -0.9475 1225155 Maybridge4_001634 O=S(=O)(Nc1ccc(cc1)N2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K07 compound treatment 1.5489051E8 -5.01E7 -0.63 2.03742354E8 1.57E7 0.27 -0.2548 -0.3728 1255708 Maybridge4_001635 Nc1ccccc1C(=O)NCCN2CCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K08 compound treatment 1.51702289E8 -5.33E7 -0.67 1.84643338E8 -3420000.0 -0.06 -0.5143 -0.7662 1132174 Maybridge4_001636 CC(C)N(Cc1ccccc1)S(=O)(=O)c2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K09 compound treatment 1.04104197E8 -1.01E8 -1.27 1.29340664E8 -5.87E7 -1.01 -1.6059 -0.9935 1685251 Maybridge4_001637 COc1cc2CCN(C(C)c2cc1OC)C(=O)c3nn(nc3C)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K10 compound treatment 1.48550062E8 -5.65E7 -0.71 1.88783285E8 715000.0 0.01 -0.4921 -0.6948 1481631 Maybridge4_001638 COc1ccc(cc1)C(=O)Nc2ccc(Oc3ncnc4cc(Cl)ccc34)nc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K11 compound treatment 1.69308854E8 -3.57E7 -0.45 1.98876253E8 1.08E7 0.19 -0.1858 -0.3835 1418693 Maybridge4_001639 OC(CNS(=O)(=O)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K12 compound treatment 1.49068143E8 -5.59E7 -0.7 1.53800394E8 -3.43E7 -0.59 -0.911 -0.996 3179042 Maybridge4_001640 Clc1ccc(cc1)C(=O)CSc2nnc(CSc3nnc(c4ccccc4)n3CC=C)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K13 compound treatment 1.6123669E8 -4.38E7 -0.55 1.32033391E8 -5.6E7 -0.96 -1.0665 -0.965 1429598 Maybridge4_001641 C(N1CCN(CC1)c2ccccn2)c3c[nH]c(n3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K14 compound treatment 1.60484023E8 -4.45E7 -0.56 1.5259601E8 -3.55E7 -0.61 -0.8243 -0.9991 1175807 Maybridge4_001642 C1Cc2nc3ncnn3c(N4CCN(CC4)c5ccccc5)c2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K15 compound treatment 1.72013569E8 -3.3E7 -0.41 1.45077964E8 -4.3E7 -0.74 -0.813 -0.9629 1227234 Maybridge4_001643 CCOC(=O)c1cc(=O)c2ccc(OCC(=O)Nc3ccccc3)cc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K16 compound treatment 1.88895803E8 -1.61E7 -0.2 1.32177834E8 -5.59E7 -0.96 -0.8194 -0.838 3179043 Maybridge4_001644 Cc1onc(NC(=O)CSCC(=O)O)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K17 compound treatment 2.04738281E8 -267000.0 0.0 1.37400368E8 -5.07E7 -0.87 -0.6157 -0.7098 1228665 Maybridge4_001645 O=C(Oc1ccccc1N2CCOCC2)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K18 compound treatment 2.1176216E8 6760000.0 0.08 1.49693041E8 -3.84E7 -0.66 -0.4046 -0.6108 3179044 Maybridge4_001646 CN(C1CCCCC1)C(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K19 compound treatment 1.68751903E8 -3.63E7 -0.45 1.1524727E8 -7.28E7 -1.25 -1.203 -0.9066 3179045 Maybridge4_001647 COc1ccc(Cc2nnc(SCC(=O)C(C)(C)C)n2c3ccc(F)cc3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K20 compound treatment 2.28681989E8 2.37E7 0.3 1.7754021E8 -1.05E7 -0.18 0.0826 0.2377 3063747 Maybridge4_001648 COc1cccc(NC(=O)NCCN2CCN=C2C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K21 compound treatment 2.18662221E8 1.37E7 0.17 1.54363859E8 -3.37E7 -0.58 -0.2868 -0.4766 1463967 Maybridge4_001649 Cc1ccc(cc1)C(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K22 compound treatment 2.02235785E8 -2770000.0 -0.03 1.04030035E8 -8.4E7 -1.44 -1.0418 -0.724 1183986 Maybridge4_001650 O=C(Nc1cccs1)Nc2nnc(s2)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K23 mock treatment 2.09150796E8 4150000.0 0.05 1.02311284E8 -8.58E7 -1.47 -1.0013 -0.6816 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 K24 mock treatment 1.97157884E8 -7850000.0 -0.1 1.65650939E8 -2.24E7 -0.38 -0.341 -0.8606 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L01 compound treatment 1.66975629E8 -3.8E7 -0.48 1.52406994E8 -3.57E7 -0.61 -0.769 -0.9926 3179046 Maybridge4_001651 CC(C)c1ccc(NC(=O)CSc2nnc(O)n2C3CC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L02 compound treatment 2.03936266E8 -1070000.0 -0.01 1.62814645E8 -2.53E7 -0.43 -0.3152 -0.7287 3063748 Maybridge4_001652 CC(C)(CC(=O)Nc1ccc(F)cc1)Sc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L03 compound treatment 1.86761494E8 -1.82E7 -0.23 1.66609999E8 -2.15E7 -0.37 -0.4216 -0.9741 1296513 Maybridge4_001653 Cc1ccccc1NC(=O)Nc2ccccc2N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L04 compound treatment 1.91641088E8 -1.34E7 -0.17 1.52801821E8 -3.53E7 -0.6 -0.5454 -0.8705 3179047 Maybridge4_001654 O=c1[nH]cc(N2CCN(Cc3ccccc3)CC2)c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L05 compound treatment 1.72795129E8 -3.22E7 -0.4 1.40258824E8 -4.78E7 -0.82 -0.8644 -0.9471 1703134 Maybridge4_001655 CC(C)(C)c1ccc(Oc2ccc(NC(=O)c3ccccc3)cn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L06 compound treatment 1.89091567E8 -1.59E7 -0.2 1.55854288E8 -3.22E7 -0.55 -0.5311 -0.9056 3179048 Maybridge4_001656 Cc1nc2n(CC=C)c(=S)sc2c(=O)n1/N=C/c3ccc(Cl)cc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L07 compound treatment 1.48206862E8 -5.68E7 -0.71 1.18049375E8 -7.0E7 -1.2 -1.3513 -0.9691 3063749 Maybridge4_001657 CN(C)C(=O)Oc1nnc(SCC(=O)c2ccc3OCCOc3c2)n1C4Cc5ccccc5C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L08 compound treatment 1.97437465E8 -7570000.0 -0.09 1.49709887E8 -3.84E7 -0.66 -0.5314 -0.801 1284108 Maybridge4_001658 C1CCc2c(C1)sc3ncnc(Oc4ccccc4)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L09 compound treatment 1.60210034E8 -4.48E7 -0.56 8.3214214E7 -1.05E8 -1.79 -1.6665 -0.8861 1451783 Maybridge4_001659 Cc1ccc2cc(OC(=O)c3ccc(Oc4cc(Cl)cc(Cl)c4)o3)ccc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L10 compound treatment 2.07127559E8 2120000.0 0.03 9.2508178E7 -9.56E7 -1.64 -1.1379 -0.6955 3063750 Maybridge4_001660 C=CCNC(=S)Nc1sc2CCCCc2c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L11 compound treatment 1.90571366E8 -1.44E7 -0.18 1.48258224E8 -3.98E7 -0.68 -0.6099 -0.865 1501773 Maybridge4_001661 CC(C)N(Cc1ccccc1)C(=O)Nc2c(C)onc2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L12 compound treatment 1.19761534E8 -8.52E7 -1.07 9.1106533E7 -9.7E7 -1.66 -1.9298 -0.9774 3063751 Maybridge4_001662 Clc1ccc(cc1)C2CCC(CC2)C(=O)NCc3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L13 compound treatment 1.565568E8 -4.84E7 -0.61 1.27656636E8 -6.04E7 -1.03 -1.161 -0.9679 3179049 Maybridge4_001663 Cc1nc2n(CC=C)c(=S)sc2c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L14 compound treatment 2.11289005E8 6280000.0 0.08 1.63543073E8 -2.45E7 -0.42 -0.2411 -0.5645 3063752 Maybridge4_001664 COC(=O)c1cccc(NC(=O)C2=NNC(=O)CC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L15 compound treatment 2.27169749E8 2.22E7 0.28 1.7088781E8 -1.72E7 -0.29 -0.0114 -0.028 1342676 Maybridge4_001665 Cc1noc(C)c1c2nc(CSc3nnc(O)n3C4CC4)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L16 compound treatment 2.19765119E8 1.48E7 0.19 1.68345917E8 -1.97E7 -0.34 -0.1078 -0.28 3179050 Maybridge4_001666 FC(F)(F)c1ccnc(SCn2c(=S)sc3ccccc23)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L17 compound treatment 1.58526102E8 -4.65E7 -0.58 1.45374873E8 -4.27E7 -0.73 -0.9291 -0.9937 3063753 Maybridge4_001667 Cc1ccnc(SCn2c(=S)sc3ccccc23)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L18 compound treatment 2.21571469E8 1.66E7 0.21 1.09878878E8 -7.82E7 -1.34 -0.7995 -0.5902 3179051 Maybridge4_001668 CCOC(=O)C1=NN(C(=C2C(=O)c3ccccc3C2=O)S1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L19 compound treatment 1.76699083E8 -2.83E7 -0.36 1.39253346E8 -4.88E7 -0.84 -0.842 -0.9273 3063754 Maybridge4_001669 Cc1ccc(Oc2ncccc2NC(=O)c3ccc4OCCCOc4c3)c5CCCc51 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L20 compound treatment 1.9976236E8 -5240000.0 -0.07 1.52273975E8 -3.58E7 -0.61 -0.4798 -0.7785 3179052 Maybridge4_001670 CCOC(=O)N1CCC(CC1)NS(=O)(=O)c2ccc(C)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L21 compound treatment 1.9540307E8 -9600000.0 -0.12 1.50702967E8 -3.74E7 -0.64 -0.5375 -0.8258 3179053 Maybridge4_001671 Cc1cc(C)c(c(C)c1)n2c(O)nnc2SCC(=O)Nc3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L22 compound treatment 1.82344089E8 -2.27E7 -0.28 1.48357689E8 -3.97E7 -0.68 -0.6817 -0.9252 3063755 Maybridge4_001672 Fc1ccc(cc1)S(=O)(=O)Nc2n[nH]c(SCc3ccc(Cl)cc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L23 mock treatment 2.0531223E8 307000.0 0.0 1.50498112E8 -3.76E7 -0.64 -0.452 -0.7029 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 L24 mock treatment 1.94527796E8 -1.05E7 -0.13 1.77464375E8 -1.06E7 -0.18 -0.2213 -0.9874 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M01 compound treatment 3.2664974E7 -1.72E8 -2.16 7.4106172E7 -1.14E8 -1.95 -2.9081 -0.9987 1161393 Maybridge4_001673 Cc1c(cnc2cc3OCOc3cc12)c4nnnn4c5ccc(F)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M02 compound treatment 3.6721075E7 -1.68E8 -2.11 1.13521689E8 -7.45E7 -1.28 -2.3951 -0.9709 3063756 Maybridge4_001674 Cc1cc(C)c2cc([nH]c2c1)C(=O)N3CCN(CC3)c4ncccc4C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M03 compound treatment 3.8886606E7 -1.66E8 -2.08 1.21614244E8 -6.65E7 -1.14 -2.2779 -0.9595 1702105 Maybridge4_001675 Fc1ccccc1NC(=O)NC2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M04 compound treatment 8.5182477E7 -1.2E8 -1.5 1.46984763E8 -4.11E7 -0.7 -1.5602 -0.9401 1481828 Maybridge4_001676 OC(=O)c1ccc2nc3ccsc3c(=O)n2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M05 compound treatment 7.6393987E7 -1.29E8 -1.61 1.04489635E8 -8.36E7 -1.43 -2.1525 -0.9982 3063779 Maybridge4_001677 FC(F)(F)c1ccc(nc1)N2CCN(Cc3c[nH]nc3c4ccccc4)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M06 compound treatment 9.5786711E7 -1.09E8 -1.37 1.36003045E8 -5.21E7 -0.89 -1.599 -0.9783 3063780 Maybridge4_001678 O=S(=O)(N1CCC2(CC1)OCCO2)c3ccc(s3)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M07 compound treatment 9.3936175E7 -1.11E8 -1.39 1.60929586E8 -2.71E7 -0.46 -1.3137 -0.8945 3063781 Maybridge4_001679 Cc1c(cnn1c2ccc(F)cc2)C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M08 compound treatment 9.2223099E7 -1.13E8 -1.41 1.37306993E8 -5.08E7 -0.87 -1.6148 -0.9726 1213448 Maybridge4_001680 O=C(Nc1csc2ccccc12)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M09 compound treatment 5.7381638E7 -1.48E8 -1.85 7.8243872E7 -1.1E8 -1.88 -2.6388 -1.0 1543617 Maybridge4_001681 COc1cc2CCN(C(C)c2cc1OC)S(=O)(=O)c3ccc(s3)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M10 compound treatment 1.00660395E8 -1.04E8 -1.31 1.3410281E8 -5.4E7 -0.92 -1.5788 -0.9854 1698439 Maybridge4_001682 Fc1ccc(cc1)C(=O)COc2ncnc3cc(Cl)ccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M11 compound treatment 9.5025338E7 -1.1E8 -1.38 1.30933462E8 -5.71E7 -0.98 -1.6671 -0.9858 1129209 Maybridge4_001683 CC(C)(C)c1ccc(NC(=O)Nc2ccc3OCCOc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M12 compound treatment 1.06847499E8 -9.82E7 -1.23 1.34070243E8 -5.4E7 -0.92 -1.5243 -0.99 1441238 Maybridge4_001684 CC(=O)N(C(=O)C)n1c(C)nc2c(sc3nnc(c4ccccc4)c(c5ccccc5)c32)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M13 compound treatment 1.08508718E8 -9.65E7 -1.21 1.53312721E8 -3.48E7 -0.59 -1.2766 -0.9465 1158309 Maybridge4_001685 O=C(Nc1ccccc1)Oc2ccccc2N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M14 compound treatment 1.02839605E8 -1.02E8 -1.28 1.17766771E8 -7.03E7 -1.2 -1.7572 -0.9995 1618806 Maybridge4_001686 C(N(Cc1ccccc1)c2c3CCCc3nc4ncnn24)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M15 compound treatment 1.27866924E8 -7.71E7 -0.97 1.60457739E8 -2.76E7 -0.47 -1.0184 -0.9457 1328356 Maybridge4_001687 Clc1ccc(cc1)C(=O)Nc2ccc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M16 compound treatment 1.26477715E8 -7.85E7 -0.99 1.46751441E8 -4.13E7 -0.71 -1.1967 -0.9868 1356245 Maybridge4_001688 Cc1cc(C)c2cc([nH]c2c1)C(=O)N3CCC(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M17 compound treatment 1.10438315E8 -9.46E7 -1.19 1.30667948E8 -5.74E7 -0.98 -1.5336 -0.9956 3063782 Maybridge4_001689 Clc1ccc(Sc2ncccc2C(=O)Oc3ccccc3N4CCOCC4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M18 compound treatment 1.3322174E8 -7.18E7 -0.9 1.61416247E8 -2.67E7 -0.46 -0.9593 -0.9503 1407054 Maybridge4_001690 CN(C1CCCCC1)S(=O)(=O)c2ccc(s2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M19 compound treatment 1.22143438E8 -8.29E7 -1.04 1.38753628E8 -4.93E7 -0.84 -1.3319 -0.9947 1657796 Maybridge4_001691 Cc1ccc(cc1)S(=O)(=O)Nc2ccccc2Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M20 compound treatment 1.16780702E8 -8.82E7 -1.11 1.61845149E8 -2.62E7 -0.45 -1.1 -0.921 3179139 Maybridge4_001692 CC1=NCCN1CCNC(=O)Nc2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M21 compound treatment 1.55382516E8 -4.96E7 -0.62 1.16905325E8 -7.12E7 -1.22 -1.3015 -0.9514 1606643 Maybridge4_001693 O=C1N(CCCN2CCOCC2)C(Nc3ccccc13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M22 compound treatment 1.14005289E8 -9.1E7 -1.14 1.55253359E8 -3.28E7 -0.56 -1.2044 -0.9467 1220768 Maybridge4_001694 OC(=O)COCC(=O)Nc1nnc(s1)C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M23 mock treatment 1.02150109E8 -1.03E8 -1.29 1.77118857E8 -1.09E7 -0.19 -1.0449 -0.8014 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 M24 mock treatment 9.9622021E7 -1.05E8 -1.32 1.41845164E8 -4.62E7 -0.79 -1.4943 -0.9699 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N01 compound treatment 1.66089921E8 -3.89E7 -0.49 1.83252991E8 -4820000.0 -0.08 -0.4035 -0.815 1585891 Maybridge4_001695 CCc1cccc(C)c1NC(=O)N(Cc2ccccc2)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N02 compound treatment 1.65416169E8 -3.96E7 -0.5 1.91994558E8 3930000.0 0.07 -0.3036 -0.6059 3063783 Maybridge4_001696 CC1CC(=O)Nc2ccccc2N1S(=O)(=O)c3ccc(s3)c4cc(on4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N03 compound treatment 1.49260378E8 -5.57E7 -0.7 1.66114573E8 -2.2E7 -0.38 -0.7602 -0.9576 1262463 Maybridge4_001697 O=C(Nc1cccs1)Nc2ccccc2N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N04 compound treatment 1.46173671E8 -5.88E7 -0.74 1.61843265E8 -2.62E7 -0.45 -0.8393 -0.9716 3179140 Maybridge4_001698 Fc1cn(CC2CC(=NO2)c3ccccc3)c(=O)n(CC4CC(=NO4)c5ccccc5)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N05 compound treatment 1.54782526E8 -5.02E7 -0.63 1.70085986E8 -1.8E7 -0.31 -0.6632 -0.9457 1190724 Maybridge4_001699 CC(C)(C)c1ccc(Oc2ccc(NC(=O)Nc3cccs3)cn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N06 compound treatment 1.4657598E8 -5.84E7 -0.73 9.8990954E7 -8.91E7 -1.52 -1.5965 -0.9436 3179141 Maybridge4_001700 COc1cc(/C=N/n2cnc3n(C)c(=S)sc3c2=O)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N07 compound treatment 1.55756577E8 -4.92E7 -0.62 1.739555E8 -1.41E7 -0.24 -0.6077 -0.9161 3063784 Maybridge4_001701 CN(C)C(=O)Oc1nnc(SCCS(=O)(=O)c2ccc(F)cc2)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N08 compound treatment 1.53394592E8 -5.16E7 -0.65 1.13820574E8 -7.42E7 -1.27 -1.3565 -0.951 3179142 Maybridge4_001702 CCOC(=O)c1c(SC)n(c2ccccc2)c(=S)n(c3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N09 compound treatment 1.10259894E8 -9.47E7 -1.19 1.73132821E8 -1.49E7 -0.26 -1.0212 -0.84 1226040 Maybridge4_001703 CC(=O)N1CCN(CC1)c2ccc(OC(=O)c3ccc(Oc4cc(Cl)cc(Cl)c4)o3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N10 compound treatment 1.64824116E8 -4.02E7 -0.5 1.86250069E8 -1820000.0 -0.03 -0.3784 -0.7493 3063785 Maybridge4_001704 CN(C)/C=N\c1cc(C)c(C#N)c2nc3ccccc3n12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N11 compound treatment 1.19148199E8 -8.59E7 -1.08 1.80974415E8 -7090000.0 -0.12 -0.8474 -0.7819 1109792 Maybridge4_001705 OC(CN1CCOCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N12 compound treatment 1.48859231E8 -5.61E7 -0.7 1.62423107E8 -2.56E7 -0.44 -0.8084 -0.9741 3179143 Maybridge4_001706 O=C(Cn1cc(nc1SCc2ccccc2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N13 compound treatment 1.16897056E8 -8.81E7 -1.11 1.42035084E8 -4.6E7 -0.79 -1.3387 -0.9862 1537386 Maybridge4_001707 C=CCn1c(Sc2ncnc3n(ncc23)c4ccccc4)nnc1c5ccncc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N14 compound treatment 1.55027115E8 -5.0E7 -0.63 1.9085297E8 2780000.0 0.05 -0.4096 -0.6515 3063786 Maybridge4_001708 Fc1cc(F)cc(NC(=O)C2=NNC(=O)CC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N15 compound treatment 1.55508055E8 -4.95E7 -0.62 1.59732882E8 -2.83E7 -0.49 -0.782 -0.9925 1514475 Maybridge4_001709 CN(CCc1ccccn1)C(=O)c2c(C)onc2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N16 compound treatment 1.31964088E8 -7.3E7 -0.92 1.57175828E8 -3.09E7 -0.53 -1.0218 -0.9659 1207655 Maybridge4_001710 CCOc1ncc(c2nnnn2c3ccc(C)cc3)c(n1)c4cccc(Cl)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N17 compound treatment 1.06757264E8 -9.82E7 -1.23 1.58816833E8 -2.93E7 -0.5 -1.2256 -0.9213 3179144 Maybridge4_001711 COc1ccc(cc1)C(=O)CSc2nnc(O)n2Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N18 compound treatment 6.4815635E7 -1.4E8 -1.76 1.16187792E8 -7.19E7 -1.23 -2.1136 -0.9847 3063787 Maybridge4_001712 CC1CN(CC(C)O1)c2ccc3nnc(c4ccc(cc4)C(F)(F)F)n3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N19 compound treatment 1.26354634E8 -7.87E7 -0.99 1.58362999E8 -2.97E7 -0.51 -1.0572 -0.9525 3179145 Maybridge4_001713 FC(F)(F)c1ccc(cc1)C(=O)n2ccc(n2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N20 compound treatment 6.8481265E7 -1.37E8 -1.71 1.36452386E8 -5.16E7 -0.88 -1.8358 -0.9526 3179146 Maybridge4_001714 CCCc1c(cnn1c2ccccc2)C(=O)NC3CCN(CC3)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N21 compound treatment 7.5832333E7 -1.29E8 -1.62 1.25032181E8 -6.3E7 -1.08 -1.9088 -0.9805 3063788 Maybridge4_001715 Cc1cc(C)c(c(C)c1)n2c(O)nnc2SCc3nc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N22 compound treatment 9.7694981E7 -1.07E8 -1.35 1.21137369E8 -6.69E7 -1.15 -1.762 -0.9968 3179147 Maybridge4_001716 O=C(Nc1ccccc1)N2CCN(CC2)c3ncccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N23 mock treatment 7.8378735E7 -1.27E8 -1.59 1.61362638E8 -2.67E7 -0.46 -1.4465 -0.8751 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 N24 mock treatment 9.7536732E7 -1.07E8 -1.35 1.52755074E8 -3.53E7 -0.6 -1.3807 -0.9345 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O01 compound treatment 3.3833778E7 -1.71E8 -2.15 1.08131454E8 -7.99E7 -1.37 -2.4859 -0.9763 3063789 Maybridge4_001717 NC(=O)C1CCN(CC(O)(c2ccccc2)c3ccccc3)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O02 compound treatment 4.7716504E7 -1.57E8 -1.97 1.29094018E8 -5.9E7 -1.01 -2.109 -0.9516 1354647 Maybridge4_001718 O=C1N(Cc2ccccc2)Cc3c1[nH]c4cc(nn4c3=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O03 compound treatment 5.9881197E7 -1.45E8 -1.82 1.34314365E8 -5.38E7 -0.92 -1.9379 -0.95 1618786 Maybridge4_001719 O=C(NC1CCCc2ccccc12)Nc3ccc(OCc4ccccc4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O04 compound treatment 1.24193955E8 -8.08E7 -1.01 1.4760174E8 -4.05E7 -0.69 -1.2066 -0.9828 1669773 Maybridge4_001720 NC(=O)c1ccc2nc3ccsc3c(=O)n2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O05 compound treatment 1.54938717E8 -5.01E7 -0.63 1.3200858E8 -5.61E7 -0.96 -1.1227 -0.9789 1411321 Maybridge4_001721 COc1ccc(cc1)c2n[nH]cc2CN3CCC(CC3)c4ccccc4OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O06 compound treatment 1.92207875E8 -1.28E7 -0.16 1.59054301E8 -2.9E7 -0.5 -0.4647 -0.8903 1472712 Maybridge4_001722 Cc1cc(=O)oc2cc(NC(=O)CC(CC(=O)O)c3ccccc3)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O07 compound treatment 1.6349557E8 -4.15E7 -0.52 1.43966641E8 -4.41E7 -0.75 -0.902 -0.9836 1310764 Maybridge4_001723 Fc1ccc(cc1)N2CCN(CC2)C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O08 compound treatment 1.58050227E8 -4.7E7 -0.59 1.44584892E8 -4.35E7 -0.74 -0.9428 -0.9933 1239250 Maybridge4_001724 O=C(Nc1csc2ccccc12)N3CCN(CC3)C(c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O09 compound treatment 1.48887169E8 -5.61E7 -0.7 1.33707334E8 -5.44E7 -0.93 -1.1558 -0.9905 1699746 Maybridge4_001725 COc1cc2CCN(C(C)c2cc1OC)C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O10 compound treatment 1.6082412E8 -4.42E7 -0.55 1.34423109E8 -5.36E7 -0.92 -1.0412 -0.9708 1354931 Maybridge4_001726 Cc1cc(no1)c2nc(CCn3c(=O)oc4ccc(C)cc34)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O11 compound treatment 1.56939354E8 -4.81E7 -0.6 1.48371462E8 -3.97E7 -0.68 -0.9069 -0.9982 1136980 Maybridge4_001727 O=C(Nc1cccs1)Nc2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O12 compound treatment 1.83497202E8 -2.15E7 -0.27 1.73227064E8 -1.48E7 -0.25 -0.3704 -0.9995 3179148 Maybridge4_001728 Clc1ccc(CS/C(=N\c2ccccc2)/C(C#N)c3nc4ccccc4[nH]3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O13 compound treatment 1.62528915E8 -4.25E7 -0.53 1.55396867E8 -3.27E7 -0.56 -0.7722 -0.9997 1462458 Maybridge4_001729 Clc1ccsc1C(=O)Oc2ccccc2N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O14 compound treatment 1.3670414E8 -6.83E7 -0.86 1.46107723E8 -4.2E7 -0.72 -1.1138 -0.9962 3179149 Maybridge4_001730 Cn1c(Sc2c3CCCc3nc4ncnn24)nnc1c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O15 compound treatment 1.41193828E8 -6.38E7 -0.8 1.60881333E8 -2.72E7 -0.47 -0.8951 -0.9667 1250957 Maybridge4_001731 Cn1nccc1NC(=O)COCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O16 compound treatment 1.12848344E8 -9.22E7 -1.16 1.29593578E8 -5.85E7 -1.0 -1.5253 -0.9974 1424513 Maybridge4_001732 COc1cc2CCN(C(C)c2cc1OC)C(=O)c3cc4c(C)cc(C)cc4[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O17 compound treatment 1.17609896E8 -8.74E7 -1.1 1.40799682E8 -4.73E7 -0.81 -1.3474 -0.9888 3063791 Maybridge4_001733 Cc1c(CN2CCN(CC2)c3ccccn3)sc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O18 compound treatment 1.25636084E8 -7.94E7 -1.0 1.50599007E8 -3.75E7 -0.64 -1.1576 -0.9774 1224470 Maybridge4_001734 CN(CCc1ccccn1)C(=O)c2cccnc2Oc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O19 compound treatment 1.08034015E8 -9.7E7 -1.22 1.22354828E8 -6.57E7 -1.12 -1.6556 -0.9992 1228387 Maybridge4_001735 O=S(=O)(Nc1ccccc1Oc2ccccc2)c3ccc(s3)c4ccon4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O20 compound treatment 1.35443699E8 -6.96E7 -0.87 1.53833345E8 -3.42E7 -0.59 -1.0314 -0.9812 3179150 Maybridge4_001736 CC1=NCCN1CCNC(=O)Nc2cc(C)cc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O21 compound treatment 1.9767557E8 -7330000.0 -0.09 2.17618794E8 2.96E7 0.51 0.2927 0.5692 1638495 Maybridge4_001737 O=C1NCCN1CCN2C(Nc3ccccc3C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O22 compound treatment 1.37167408E8 -6.78E7 -0.85 1.49551857E8 -3.85E7 -0.66 -1.068 -0.992 3063793 Maybridge4_001738 Cc1nn(nc1c2nnc(o2)c3cccc4ccccc34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O23 mock treatment 1.41521759E8 -6.35E7 -0.8 1.51772245E8 -3.63E7 -0.62 -1.0025 -0.9925 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 O24 mock treatment 1.41760303E8 -6.32E7 -0.79 1.6135536E8 -2.67E7 -0.46 -0.8843 -0.9657 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P01 compound treatment 1.55986329E8 -4.9E7 -0.61 1.62787363E8 -2.53E7 -0.43 -0.7408 -0.9852 1685839 Maybridge4_001739 CN(C1CCCCC1)C(=O)NS(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P02 compound treatment 1.57940378E8 -4.71E7 -0.59 1.6446503E8 -2.36E7 -0.4 -0.7032 -0.9829 3063794 Maybridge4_001740 CC(C)c1ccc(NC(=O)C2=NNC(=O)CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P03 compound treatment 1.48276344E8 -5.67E7 -0.71 1.41601003E8 -4.65E7 -0.8 -1.0657 -0.9985 1248453 Maybridge4_001741 Oc1cc2c(coc2c3ccccc13)C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P04 compound treatment 1.49525527E8 -5.55E7 -0.7 1.47787704E8 -4.03E7 -0.69 -0.9797 -1.0 1427084 Maybridge4_001742 S=C(Nc1ccccc1)N2CCCCC2c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P05 compound treatment 1.16972268E8 -8.8E7 -1.1 1.13829609E8 -7.42E7 -1.27 -1.6795 -0.9976 1556607 Maybridge4_001743 CC(C)(C)c1ccc(Oc2ccc(NC(=O)CC(C)(C)CC(=O)O)cn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P06 compound treatment 1.57658494E8 -4.73E7 -0.59 9.4446973E7 -9.36E7 -1.6 -1.5532 -0.9088 1313218 Maybridge4_001744 N#Cc1c2CCCc2c(N3CCCCC3)n4c5ccccc5nc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P07 compound treatment 1.64553746E8 -4.05E7 -0.51 1.47344618E8 -4.07E7 -0.7 -0.8517 -0.9878 3063820 Maybridge4_001745 O=C(CSc1nnc(OC(=O)c2cccs2)n1C3CC3)c4ccc5OCCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P08 compound treatment 1.47249414E8 -5.78E7 -0.72 1.58190027E8 -2.99E7 -0.51 -0.874 -0.9855 3063821 Maybridge4_001746 Cc1nn(cc1C2C=C(N=C3SCC(=O)N23)c4ccc(Cl)cc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P09 compound treatment 1.08650344E8 -9.64E7 -1.21 1.05393503E8 -8.27E7 -1.42 -1.8554 -0.9969 3063822 Maybridge4_001747 Cc1nc(cn1C)S(=O)(=O)N2CCN(CC2)C3c4ccccc4-c5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P10 compound treatment 1.5976353E8 -4.52E7 -0.57 1.4854728E8 -3.95E7 -0.68 -0.8797 -0.9962 3063823 Maybridge4_001748 O=C1N(Cc2ccc3nonc3c2)S(=O)(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P11 compound treatment 1.49098813E8 -5.59E7 -0.7 1.41955268E8 -4.61E7 -0.79 -1.0541 -0.9983 1323976 Maybridge4_001749 Fc1ccc(cc1)C(=O)Nc2ccc3[nH]ccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P12 compound treatment 1.51698723E8 -5.33E7 -0.67 1.56384533E8 -3.17E7 -0.54 -0.8564 -0.9946 3179235 Maybridge4_001750 Cc1ccccc1C(=O)Nc2n[nH]c(SCc3ccc(Cl)cc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P13 compound treatment 1.56272171E8 -4.87E7 -0.61 1.53273177E8 -3.48E7 -0.6 -0.8534 -0.9999 1141633 Maybridge4_001751 Cc1cc(NC(=O)Nc2ccccc2)n(n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P14 compound treatment 1.65181164E8 -3.98E7 -0.5 1.70035394E8 -1.8E7 -0.31 -0.5715 -0.9732 3179236 Maybridge4_001752 Cc1c(/C=N/N2C(=O)CNC2=S)c(=O)n3c4ccccc4[nH]c3c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P15 compound treatment 1.50009954E8 -5.5E7 -0.69 1.44220941E8 -4.38E7 -0.75 -1.0186 -0.9991 3063825 Maybridge4_001753 O=C(NCCc1cccs1)N2CCN(CC2)C3c4ccccc4-c5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P16 compound treatment 1.40261231E8 -6.47E7 -0.81 1.43240233E8 -4.48E7 -0.77 -1.1169 -0.9996 3179237 Maybridge4_001754 O=C(Nc1ccc2OCCOc2c1)C3Cc4ccccc4N3C(=O)OCc5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P17 compound treatment 1.45930504E8 -5.91E7 -0.74 1.55170825E8 -3.29E7 -0.56 -0.9222 -0.9908 3179238 Maybridge4_001755 Cc1noc(C)c1CSc2nnc(O)n2Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P18 compound treatment 1.36476919E8 -6.85E7 -0.86 1.60772211E8 -2.73E7 -0.47 -0.9383 -0.9589 3063826 Maybridge4_001756 NNC(=O)C1N(N=C(C=C1C(=O)NN)C(=O)c2cccs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P19 compound treatment 1.38641221E8 -6.64E7 -0.83 1.57013841E8 -3.11E7 -0.53 -0.9646 -0.9765 3179239 Maybridge4_001757 Cc1cc(C(=O)n2ccc(n2)c3cccs3)c(C)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P20 compound treatment 1.4705386E8 -5.8E7 -0.73 1.56012404E8 -3.21E7 -0.55 -0.9021 -0.9904 1543173 Maybridge4_001758 CCOC(=O)N1CCC(CC1)NC(=O)c2cc(C)on2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P21 compound treatment 1.45965361E8 -5.9E7 -0.74 1.43309481E8 -4.48E7 -0.77 -1.0655 -0.9999 3179240 Maybridge4_001759 COc1ccc(NC(=O)COCC(=O)O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P22 compound treatment 1.30179807E8 -7.48E7 -0.94 1.48720741E8 -3.93E7 -0.67 -1.14 -0.9867 3179241 Maybridge4_001760 Cc1onc(c1C(=O)NCC2COc3ccccc3O2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P23 mock treatment 1.39937215E8 -6.51E7 -0.82 1.5198802E8 -3.61E7 -0.62 -1.0139 -0.9905 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2053 P24 mock treatment 1.35471293E8 -6.95E7 -0.87 1.6192205E8 -2.61E7 -0.45 -0.9333 -0.9519 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A01 compound treatment 1.19698398E8 -5.82E7 -0.73 1.95588759E8 -363000.0 -0.01 -0.5209 -0.7131 3063827 Maybridge4_001761 Cc1noc(C)c1S(=O)(=O)NCC2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A02 compound treatment 1.49366636E8 -2.86E7 -0.36 2.09432923E8 1.35E7 0.23 -0.0902 -0.2116 3179242 Maybridge4_001762 COc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)c5cccs5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A03 compound treatment 1.52661198E8 -2.53E7 -0.32 1.95479465E8 -473000.0 -0.01 -0.2298 -0.7249 3063828 Maybridge4_001763 COc1ccc(cc1)c2nnsc2N3C(=O)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A04 compound treatment 1.52068826E8 -2.59E7 -0.32 2.1125506E8 1.53E7 0.26 -0.0441 -0.1059 3179243 Maybridge4_001764 CCn1c(Cn2nnc3ccccc23)nnc1SCC(=O)c4ccc(Br)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A05 compound treatment 1.55261748E8 -2.27E7 -0.28 2.20528622E8 2.46E7 0.42 0.0964 0.1899 3179244 Maybridge4_001765 C1Cc2cc(ccc2O1)C3Nc4ccccc4-c5cccn35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A06 compound treatment 1.68270274E8 -9660000.0 -0.12 2.30212858E8 3.43E7 0.59 0.329 0.5495 3063829 Maybridge4_001766 S=C(Nc1ccccc1)N2c3ccccc3Sc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A07 compound treatment 1.6044124E8 -1.75E7 -0.22 2.37940469E8 4.2E7 0.72 0.3531 0.4699 3179245 Maybridge4_001767 O=S(=O)(NCc1ccco1)c2ccc(Oc3c(C#N)cccc3C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A08 compound treatment 1.68043684E8 -9880000.0 -0.12 2.40333995E8 4.44E7 0.76 0.4495 0.584 3063830 Maybridge4_001768 Nc1nc(Sc2nnc(c3ccncc3)n2c4ccccc4)ncc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A09 compound treatment 1.40885873E8 -3.7E7 -0.46 2.29504393E8 3.36E7 0.57 0.0776 0.105 3179246 Maybridge4_001769 Clc1ccc(COC(=O)c2ccc3ccccc3n2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A10 compound treatment 1.29605402E8 -4.83E7 -0.61 2.37136773E8 4.12E7 0.7 0.0699 0.0752 3063831 Maybridge4_001770 O=C(CSc1nnc(o1)c2ccncc2)NC(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A11 compound treatment 1.26644003E8 -5.13E7 -0.64 2.42198597E8 4.62E7 0.79 0.1049 0.1028 1526124 Maybridge4_001771 S=c1[nH]nc(c2ccncc2)n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A12 compound treatment 1.51716808E8 -2.62E7 -0.33 2.38428501E8 4.25E7 0.73 0.2817 0.353 3179247 Maybridge4_001772 S=c1[nH]c(=S)c2cnc(nc2[nH]1)N3CCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A13 compound treatment 1.69972397E8 -7950000.0 -0.1 2.3803119E8 4.21E7 0.72 0.4388 0.6034 3063832 Maybridge4_001773 Cc1cc(C)c2c(n1)sc3c(=O)n(/N=C/c4ccccc4)cnc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A14 compound treatment 1.74244726E8 -3680000.0 -0.05 2.71246144E8 7.53E7 1.29 0.8787 0.6813 3179248 Maybridge4_001774 Fc1ccc(Cn2nc3sc4ccccc4n3c(=O)c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A15 compound treatment 1.77057347E8 -869000.0 -0.01 2.33017683E8 3.71E7 0.63 0.4409 0.6949 3063833 Maybridge4_001775 Clc1ccccc1Cn2nnc3c(=S)[nH]cnc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A16 compound treatment 1.85794088E8 7870000.0 0.1 2.44489976E8 4.85E7 0.83 0.6573 0.7856 3179249 Maybridge4_001776 CCOC(=O)c1c(C)c(C)sc1NC(=S)Nc2cc(C)nn2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A17 compound treatment 1.83210376E8 5280000.0 0.07 2.42408176E8 4.65E7 0.8 0.6092 0.7634 3063834 Maybridge4_001777 CCOC(=O)c1nnn2c1nc(N(CC)CC)c3ccccc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A18 compound treatment 1.99759255E8 2.18E7 0.27 2.7191097E8 7.6E7 1.3 1.1131 0.8377 3179250 Maybridge4_001778 Cc1cc(C)c2c(n1)sc3c(=O)n(NC(=O)Nc4ccccc4)c(C)nc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A19 compound treatment 1.97801768E8 1.99E7 0.25 2.45201658E8 4.92E7 0.84 0.7724 0.8786 3063835 Maybridge4_001779 CCOC(=O)c1nn(c2ccccc2)c3nc(=O)c(C#N)c(c4ccccc4)n13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A20 compound treatment 2.12982017E8 3.51E7 0.44 2.46073462E8 5.01E7 0.86 0.9176 0.9518 3179251 Maybridge4_001780 O=C(Cn1c(=O)n(c2ccccc2)c(=O)c3cc(sc13)c4ccccc4)c5cccs5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A21 compound treatment 2.33174313E8 5.52E7 0.69 2.66806298E8 7.09E7 1.21 1.3477 0.9648 3179252 Maybridge4_001781 COc1ccc(cc1)n2ncc(NC(=O)NCc3ccccn3)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A22 compound treatment 2.08002386E8 3.01E7 0.38 2.59711038E8 6.38E7 1.09 1.0385 0.8993 3063836 Maybridge4_001782 COc1ccc(/C=C/2\N=C(N(/N=C/c3cccnc3)C2=O)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A23 mock treatment 2.08258222E8 3.03E7 0.38 2.46616625E8 5.07E7 0.87 0.8823 0.9316 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 A24 mock treatment 2.09113775E8 3.12E7 0.39 2.51674617E8 5.57E7 0.95 0.9511 0.9225 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B01 compound treatment 2.3165417E8 5.37E7 0.67 2.5114123E8 5.52E7 0.94 1.1446 0.9863 3179253 Maybridge4_001783 OC(=O)CSc1nnc([nH]1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B02 compound treatment 1.5617473E8 -2.18E7 -0.27 1.76301154E8 -1.97E7 -0.34 -0.4308 -0.9946 3063837 Maybridge4_001784 O=c1oc2=C(c3ccccc3)S(=O)(=O)C(=c2o1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B03 compound treatment 1.72454077E8 -5470000.0 -0.07 2.42995939E8 4.7E7 0.81 0.5209 0.6445 3179254 Maybridge4_001785 Cc1cc(C)c2c3NC(=O)CN(C(=O)c3sc2n1)c4ccccc4C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B04 compound treatment 1.57536588E8 -2.04E7 -0.26 2.70758048E8 7.48E7 1.28 0.7246 0.5549 1701942 Maybridge4_001786 COc1ccc(cc1)N2C(=O)Cc3ccc(OC)cc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B05 compound treatment 1.59959807E8 -1.8E7 -0.23 2.79949606E8 8.4E7 1.44 0.8574 0.5891 3179255 Maybridge4_001787 Clc1ccc(cc1)n2c(=N)c3cnc(nc3[nH]c2=O)N4CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B06 compound treatment 1.43814003E8 -3.41E7 -0.43 3.29049113E8 1.33E8 2.28 1.3084 0.5644 1588538 Maybridge4_001788 Cc1oc2cc(O)ccc2c(=O)c1Oc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B07 compound treatment 1.29061931E8 -4.89E7 -0.61 2.52255951E8 5.63E7 0.96 0.2481 0.2172 3179256 Maybridge4_001789 COc1ccc(cc1)n/2c(cs\c2=N/Cc3cccnc3)c4cccc(OC)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B08 compound treatment 2.25470201E8 4.75E7 0.6 2.71101747E8 7.51E7 1.29 1.3314 0.9389 3179257 Maybridge4_001790 O=C(c1ccccc1)c2cccc(NC=C3C(=O)NC(=O)NC3=O)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B09 compound treatment 2.2636011E8 4.84E7 0.61 2.26579048E8 3.06E7 0.52 0.8003 0.9973 1289329 Maybridge4_001791 O=C1C(=C(c2ccccc2)S(=O)(=O)c3ccccc13)Cc4ccc(cc4)c5nnn[nH]5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B10 compound treatment 2.06030516E8 2.81E7 0.35 2.92489337E8 9.65E7 1.65 1.4178 0.8391 1270319 Maybridge4_001792 O=C(c1ccccn1)c2ccc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B11 compound treatment 1.6853669E8 -9390000.0 -0.12 2.69476902E8 7.35E7 1.26 0.8067 0.6381 1356935 Maybridge4_001793 C1C2CC3CC1CC(C2)(C3)c4cn5ccccc5n4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B12 compound treatment 2.05657288E8 2.77E7 0.35 2.68733578E8 7.28E7 1.25 1.1269 0.8712 1489551 Maybridge4_001794 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)N2CCC(CC2)NC(=O)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B13 compound treatment 1.54771896E8 -2.32E7 -0.29 2.65608309E8 6.97E7 1.19 0.6377 0.5197 3063861 Maybridge4_001795 CC(=O)O[C@@H]1[C@H]2CO[C@H](O2)[C@H](OC(=O)C)[C@H]1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B14 compound treatment 2.16061489E8 3.81E7 0.48 2.70177939E8 7.42E7 1.27 1.2367 0.9109 1649672 Maybridge4_001796 COc1cc(C(=O)CCC(=O)O)c(OC)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B15 compound treatment 2.26616415E8 4.87E7 0.61 2.58582542E8 6.26E7 1.07 1.19 0.9644 1471910 Maybridge4_001797 Cc1ccc(NC(=O)N2C(=O)C3(OCCO3)c4ccccc24)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B16 compound treatment 2.17017201E8 3.91E7 0.49 2.68961243E8 7.3E7 1.25 1.2305 0.9165 1205899 Maybridge4_001798 CCOC(=O)C1=C(C)N(C)C(=O)N(C)C1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B17 compound treatment 2.38784515E8 6.09E7 0.76 2.68195628E8 7.22E7 1.24 1.4143 0.9731 3063863 Maybridge4_001799 CC(=O)Nc1ccc2oc(cc(=O)c2c1)c3ccc(C#N)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B18 compound treatment 1.56275867E8 -2.17E7 -0.27 3.25739495E8 1.3E8 2.22 1.3789 0.6161 3179258 Maybridge4_001800 Cc1c(sc2nc(C)cc(C)c12)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B19 compound treatment 2.30909678E8 5.3E7 0.66 2.79389839E8 8.34E7 1.43 1.4799 0.9394 3063864 Maybridge4_001801 CC(O)/C=C\c1cc[n+](C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B20 compound treatment 2.30453896E8 5.25E7 0.66 2.63415623E8 6.75E7 1.15 1.2825 0.9646 3179259 Maybridge4_001802 O=C(NC(=S)NC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B21 compound treatment 2.13440898E8 3.55E7 0.45 2.61700884E8 6.57E7 1.13 1.1109 0.9177 1176828 Maybridge4_001803 COC(=O)C1C(C(C(=O)OC)S(=O)(=O)CS1(=O)=O)c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B22 compound treatment 2.17354859E8 3.94E7 0.49 2.54205854E8 5.83E7 1.0 1.0549 0.9477 1288189 Maybridge4_001804 COC(=O)C1=C(C)NC(=C(C1)C(=O)OC)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B23 mock treatment 2.16267551E8 3.83E7 0.48 2.51691857E8 5.57E7 0.95 1.0148 0.9497 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 B24 mock treatment 2.11144332E8 3.32E7 0.42 2.50892853E8 5.49E7 0.94 0.9597 0.9329 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C01 compound treatment 1.01564408E8 -7.64E7 -0.96 1.81422198E8 -1.45E7 -0.25 -0.8532 -0.8621 3179260 Maybridge4_001805 O=S(=O)(NCC1COc2ccccc2O1)c3ccc(s3)S(=O)(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C02 compound treatment 1.24500097E8 -5.34E7 -0.67 1.92661587E8 -3290000.0 -0.06 -0.5137 -0.7638 3063865 Maybridge4_001806 Fc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)c5ccco5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C03 compound treatment 1.37538002E8 -4.04E7 -0.51 1.87865997E8 -8090000.0 -0.14 -0.4561 -0.8685 3179353 Maybridge4_001807 COc1ccc(cc1OC)C(=O)NCc2ccc(C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C04 compound treatment 1.28943826E8 -4.9E7 -0.61 1.7916656E8 -1.68E7 -0.29 -0.6377 -0.9401 3063866 Maybridge4_001808 O=C(Oc1c(c2ccccc2)c(=O)n3CCc4cccc1c43)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C05 compound treatment 1.38751452E8 -3.92E7 -0.49 2.02938788E8 6990000.0 0.12 -0.2629 -0.5198 3179354 Maybridge4_001809 FC(F)(F)c1ccc(cc1)c2nnc(SCc3ccncc3)n2Cc4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C06 compound treatment 1.3949479E8 -3.84E7 -0.48 2.03879289E8 7930000.0 0.14 -0.2449 -0.4891 3063867 Maybridge4_001810 CCOC(=O)c1nnn2c1nc(Sc3nc4ccccc4o3)c5ccccc52 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C07 compound treatment 1.43075864E8 -3.49E7 -0.44 2.175696E8 2.16E7 0.37 -0.0475 -0.0829 3179355 Maybridge4_001811 COc1cccc(Cc2nnc(o2)c3c(C)onc3c4ccccc4)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C08 compound treatment 1.17509308E8 -6.04E7 -0.76 1.66449733E8 -2.95E7 -0.51 -0.893 -0.9805 3179356 Maybridge4_001812 C=CCn1c(=S)sc2c(Sc3nnc(o3)c4ccco4)ncnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C09 compound treatment 1.18471018E8 -5.95E7 -0.75 2.16583698E8 2.06E7 0.35 -0.2777 -0.3365 3063868 Maybridge4_001813 Clc1ccc(Cn2c(=O)n(Cc3ccc(Cl)cc3)c4ccccc4c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C10 compound treatment 1.10912456E8 -6.7E7 -0.84 2.17210194E8 2.13E7 0.36 -0.3371 -0.368 3179357 Maybridge4_001814 Nc1nc(SCC(=O)NC(=O)Nc2ccccc2)ncc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C11 compound treatment 9.3500433E7 -8.44E7 -1.06 1.89797622E8 -6150000.0 -0.11 -0.8234 -0.7736 2099392 Maybridge4_001815 Cc1nc2ccc(F)cc2c3N(CCc31)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C12 compound treatment 1.01363594E8 -7.66E7 -0.96 2.23621907E8 2.77E7 0.47 -0.3442 -0.3214 3179358 Maybridge4_001816 C=CCSc1ncc2c(=S)[nH]c(=S)[nH]c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C13 compound treatment 1.19187375E8 -5.87E7 -0.74 2.30150404E8 3.42E7 0.59 -0.1071 -0.1138 3179359 Maybridge4_001817 Cc1cc(C)c2c(n1)sc3c(SCC(=O)c4ccc(Br)cc4)ncnc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C14 compound treatment 1.38587087E8 -3.93E7 -0.49 2.24456421E8 2.85E7 0.49 -0.0039 -0.0057 3063869 Maybridge4_001818 C=CCn1nc2sc3ccccc3n2c(=O)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C15 compound treatment 1.56027292E8 -2.19E7 -0.27 2.3808782E8 4.21E7 0.72 0.3158 0.4091 3179360 Maybridge4_001819 COc1ccc(Nc2ncnc3n(Cc4ccccc4Cl)nnc23)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C16 compound treatment 1.42991924E8 -3.49E7 -0.44 2.10444004E8 1.45E7 0.25 -0.1345 -0.267 3063871 Maybridge4_001820 CCOC(=O)c1c(C)c(C)sc1NC(=S)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C17 compound treatment 1.36241228E8 -4.17E7 -0.52 2.05028839E8 9080000.0 0.16 -0.2599 -0.4764 3179361 Maybridge4_001821 CCOC(=O)c1nnn2c1nc(N3CCN(CC3)c4ccccc4)c5ccccc52 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C18 compound treatment 5.979336E7 -1.18E8 -1.48 7.777224E7 -1.18E8 -2.02 -2.4784 -0.9883 3063872 Maybridge4_001822 Cc1cc(C)c2c(=O)n(sc2n1)C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C19 compound treatment 1.43157878E8 -3.48E7 -0.44 2.04728167E8 8780000.0 0.15 -0.2022 -0.4383 3179362 Maybridge4_001823 COc1ccc(cc1)C2C(=C(N)N3CCc4cc(OC)c(OC)cc4C3=C2C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C20 compound treatment 1.58971695E8 -1.9E7 -0.24 2.05338233E8 9390000.0 0.16 -0.0545 -0.19 3063873 Maybridge4_001824 CNC(=O)NC(=O)Cn1cnc2sc(cc2c1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C21 compound treatment 1.6114176E8 -1.68E7 -0.21 2.1404762E8 1.81E7 0.31 0.0701 0.1873 3179363 Maybridge4_001825 COc1cc2CCN3C(N(N=C3C(=O)c4cccs4)c5ccccc5)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C22 compound treatment 1.80872653E8 2950000.0 0.04 2.17304074E8 2.14E7 0.37 0.2846 0.7747 3063874 Maybridge4_001826 Fc1ccc(/C=N/N2C(=O)/C(=C/c3ccco3)/N=C2c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C23 mock treatment 1.6856657E8 -9360000.0 -0.12 2.23877694E8 2.79E7 0.48 0.255 0.518 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 C24 mock treatment 1.7450706E8 -3420000.0 -0.04 2.21654271E8 2.57E7 0.44 0.2808 0.6352 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D01 compound treatment 1.87942311E8 1.0E7 0.13 2.02971261E8 7020000.0 0.12 0.1738 0.9998 3179364 Maybridge4_001827 CCOC(=O)CSc1nc(Nc2ccc(OC)cc2)c3cnc(nc3n1)N(CC)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D02 compound treatment 2.30890816E8 5.3E7 0.66 2.36436829E8 4.05E7 0.69 0.9598 0.9998 1016783 Maybridge4_001828 CSc1ncnc2[nH]cnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D03 compound treatment 1.41355679E8 -3.66E7 -0.46 2.29391292E8 3.34E7 0.57 0.0804 0.1095 3179365 Maybridge4_001829 CCOC(=O)CSc1nc(Nc2ccccc2)c3cnc(nc3n1)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D04 compound treatment 1.47949643E8 -3.0E7 -0.38 2.49263694E8 5.33E7 0.91 0.3794 0.3844 3063875 Maybridge4_001830 CCn1c(C)[n+](CC)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D05 compound treatment 1.27993423E8 -4.99E7 -0.63 2.50002194E8 5.41E7 0.93 0.2113 0.1891 3179366 Maybridge4_001831 Nc1c(C#N)c(cc2c3ccccc3oc(=O)c12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D06 compound treatment 1.90026554E8 1.21E7 0.15 2.05656459E8 9700000.0 0.17 0.2248 0.999 1156367 Maybridge4_001832 CC(=O)Oc1ccc2c(=O)c(Oc3ccc(Cl)cc3)c(C)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D07 compound treatment 1.56705092E8 -2.12E7 -0.27 2.36628495E8 4.07E7 0.7 0.3041 0.408 3179367 Maybridge4_001833 CC(/C=N/N1C(=O)c2ccccc2C1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D08 compound treatment 1.93473662E8 1.55E7 0.2 2.09315958E8 1.34E7 0.23 0.2997 0.9968 3063876 Maybridge4_001834 COC(=O)c1sc(=S)sc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D09 compound treatment 1.93254433E8 1.53E7 0.19 2.21975649E8 2.6E7 0.45 0.451 0.9294 1027030 Maybridge4_001835 Clc1ccc2OC(CC(=O)c2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D10 compound treatment 1.51589842E8 -2.63E7 -0.33 2.33073888E8 3.71E7 0.64 0.2157 0.3012 1567173 Maybridge4_001836 C=CCN1C(=O)NC2(CCCCC2)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D11 compound treatment 1.9912168E8 2.12E7 0.27 2.42283017E8 4.63E7 0.79 0.7488 0.8952 1014811 Maybridge4_001837 O=C(N(C(=O)c1ccccc1)C(=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D12 compound treatment 1.90371062E8 1.24E7 0.16 2.33195345E8 3.72E7 0.64 0.5612 0.855 1422860 Maybridge4_001838 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D13 compound treatment 1.4780059E8 -3.01E7 -0.38 2.47798117E8 5.18E7 0.89 0.3603 0.3735 3063327 Maybridge4_001839 CCOc1ccc2nc(S/C=C/C(=O)c3ccc(Cl)cc3)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D14 compound treatment 1.86914927E8 8990000.0 0.11 2.30466479E8 3.45E7 0.59 0.4975 0.8271 1403045 Maybridge4_001840 COc1cc(c(OC)cc1C)c2cc(OC)c(C)cc2OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D15 compound treatment 2.03110137E8 2.52E7 0.32 2.39224198E8 4.33E7 0.74 0.7472 0.9278 1267535 Maybridge4_001841 OC(=O)C(Sc1ccccc1C(=O)O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D16 compound treatment 2.14107886E8 3.62E7 0.45 2.33587815E8 3.76E7 0.64 0.7765 0.9853 3063328 Maybridge4_001842 CC(C)(C)[C@H]1COC(=N1)CC2=N[C@H](CO2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D17 compound treatment 1.9439212E8 1.65E7 0.21 2.30200878E8 3.42E7 0.59 0.5606 0.9019 1035033 Maybridge4_001843 O=C(C1=NNCC1c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D18 compound treatment 2.05405449E8 2.75E7 0.34 2.28098188E8 3.21E7 0.55 0.6329 0.9746 1414609 Maybridge4_001844 CC(=O)Oc1ccc2c(=O)c(c3nc4ccccc4n3C)c(C)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D19 compound treatment 2.11165343E8 3.32E7 0.42 2.30101448E8 3.41E7 0.58 0.7082 0.9863 3063329 Maybridge4_001845 CC1=CC(=O)OC(C1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D20 compound treatment 2.0294279E8 2.5E7 0.31 2.27316153E8 3.14E7 0.54 0.6015 0.9673 1054135 Maybridge4_001846 CCc1c(O)nc2ccccn2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D21 compound treatment 1.99745786E8 2.18E7 0.27 2.52298708E8 5.63E7 0.96 0.8756 0.8733 1416442 Maybridge4_001847 CCN(CC)CCC1S(=O)(=O)CC(CS1(=O)=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D22 compound treatment 1.83102549E8 5180000.0 0.06 2.14452571E8 1.85E7 0.32 0.2698 0.8347 3179368 Maybridge4_001848 C(/N=C/c1cn(nc1c2ccccc2)c3ccccc3)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D23 mock treatment 1.83036659E8 5110000.0 0.06 2.40809055E8 4.49E7 0.77 0.5883 0.7635 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 D24 mock treatment 1.81201487E8 3270000.0 0.04 2.1276612E8 1.68E7 0.29 0.2326 0.7999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E01 compound treatment 1.3040437E8 -4.75E7 -0.6 1.61896457E8 -3.41E7 -0.58 -0.8338 -0.9999 3063330 Maybridge4_001849 O=C(Nc1cccs1)N2CCN(CC2)C(=O)C3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E02 compound treatment 1.67069382E8 -1.09E7 -0.14 1.78918833E8 -1.7E7 -0.29 -0.3025 -0.9399 3179369 Maybridge4_001850 Clc1ccc(NC(=O)N2N=C3C(CCc4ccccc34)C2c5cccs5)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E03 compound treatment 1.74520943E8 -3410000.0 -0.04 1.66031191E8 -2.99E7 -0.51 -0.3924 -0.7634 3063331 Maybridge4_001851 CC(C)(C)c1cc(C(=O)NCc2ccc(C#N)cc2)n(Cc3ccccc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E04 compound treatment 1.79184714E8 1260000.0 0.02 1.8666625E8 -9290000.0 -0.16 -0.1012 -0.6338 3179370 Maybridge4_001852 C1Cc2ccccc2N1c3nnc(c4ccccc4)c(n3)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E05 compound treatment 1.85737798E8 7810000.0 0.1 1.77041001E8 -1.89E7 -0.32 -0.1596 -0.4719 3179371 Maybridge4_001853 Cn1nc(cc1C(F)(F)F)c2ccc(s2)S(=O)(=O)N3CCCN(CC3)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E06 compound treatment 2.07351875E8 2.94E7 0.37 1.98542703E8 2590000.0 0.04 0.2924 0.7864 3063332 Maybridge4_001854 CCOC(=O)c1nnn2c1nc(Sc3nnc(c4ccncc4)n3C)c5ccccc52 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E07 compound treatment 2.06173607E8 2.82E7 0.35 1.80573071E8 -1.54E7 -0.26 0.0644 0.1459 3179372 Maybridge4_001855 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCCN(CC2)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E08 compound treatment 1.81120004E8 3190000.0 0.04 2.29114869E8 3.32E7 0.57 0.4297 0.7551 1566406 Maybridge4_001856 CNc1nc(=S)[nH]c2sc3CCCCc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E09 compound treatment 1.74671947E8 -3250000.0 -0.04 1.89992006E8 -5960000.0 -0.1 -0.101 -0.9192 3179373 Maybridge4_001857 OC[C@@H]1O[C@@H](C[C@H]1O)n2cnc3c(=O)[nH]cnc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E10 compound treatment 1.64771654E8 -1.32E7 -0.17 2.11851804E8 1.59E7 0.27 0.0758 0.238 3063334 Maybridge4_001858 COc1ccc(Nc2ncc(C#N)c(N)n2)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E11 compound treatment 1.64498376E8 -1.34E7 -0.17 1.77781781E8 -1.82E7 -0.31 -0.339 -0.9585 3179374 Maybridge4_001859 CCNc1nc(=S)[nH]c2n(ncc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E12 compound treatment 1.66601113E8 -1.13E7 -0.14 1.71282519E8 -2.47E7 -0.42 -0.3991 -0.8957 3063335 Maybridge4_001860 CCN(CC)c1ncc2c(=S)[nH]c(=S)[nH]c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E13 compound treatment 1.69532196E8 -8390000.0 -0.11 1.80196111E8 -1.58E7 -0.27 -0.2652 -0.9159 3179375 Maybridge4_001861 Cc1cc(C)c2c(n1)sc3c(Sc4nnc(o4)c5ccncc5)ncnc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E14 compound treatment 1.65156148E8 -1.28E7 -0.16 1.8342557E8 -1.25E7 -0.21 -0.2649 -0.9897 3179376 Maybridge4_001862 CCOC(=O)N1CCc2c(C1)sc3ncn(Cc4ccc(Cl)cc4)c(=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E15 compound treatment 1.78548437E8 622000.0 0.01 1.86818288E8 -9130000.0 -0.16 -0.105 -0.671 3063336 Maybridge4_001863 Clc1ccccc1C2C3CCc4ccccc4C3=NN2C(=S)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E16 compound treatment 1.65407134E8 -1.25E7 -0.16 1.91319801E8 -4630000.0 -0.08 -0.1671 -0.9499 1616264 Maybridge4_001864 CC1=NN(C(=O)C1)c2ncnc3sc4CCCCc4c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E17 compound treatment 1.87990707E8 1.01E7 0.13 2.17647416E8 2.17E7 0.37 0.3519 0.8971 3179377 Maybridge4_001865 CCOC(=O)c1nnn2c1nc(N(Cc3ccccc3)Cc4ccccc4)c5ccccc52 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E18 compound treatment 1.80273989E8 2350000.0 0.03 1.91771477E8 -4180000.0 -0.07 -0.0298 -0.3848 3063337 Maybridge4_001866 NNC(=O)/C(=C\c1ccccc1)/NC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E19 compound treatment 1.99090531E8 2.12E7 0.27 1.93156062E8 -2800000.0 -0.05 0.1539 0.5704 3179378 Maybridge4_001867 Cc1ccc(Cc2nn3c(nn(c4ccc(Cl)cc4)c3nc2=O)C(=O)c5cccs5)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E20 compound treatment 1.83589038E8 5660000.0 0.07 1.91858184E8 -4090000.0 -0.07 7.0E-4 0.0068 3063338 Maybridge4_001868 Fc1ccc(Cn2nc3CSc4ccccc4-n3c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E21 compound treatment 1.92219015E8 1.43E7 0.18 1.87788448E8 -8160000.0 -0.14 0.028 0.123 3063339 Maybridge4_001869 Cc1ccc2nc(C)c3CCN(c3c2c1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E22 compound treatment 1.63412531E8 -1.45E7 -0.18 1.901025E8 -5850000.0 -0.1 -0.1995 -0.9603 3179379 Maybridge4_001870 Fc1ccc(/C=C\2/N=C(N(CC(=O)c3ccco3)C2=O)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E23 mock treatment 1.71545055E8 -6380000.0 -0.08 1.82239946E8 -1.37E7 -0.23 -0.2226 -0.8975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 E24 mock treatment 1.70706625E8 -7220000.0 -0.09 1.84713258E8 -1.12E7 -0.19 -0.2001 -0.9409 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F01 compound treatment 1.86062535E8 8140000.0 0.1 1.82600233E8 -1.34E7 -0.23 -0.0894 -0.3573 3179475 Maybridge4_001871 Cc1cc(nc2oc3C(=O)N(CC(=O)Nc3c12)c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F02 compound treatment 1.92016623E8 1.41E7 0.18 1.81455777E8 -1.45E7 -0.25 -0.0505 -0.1657 1429948 Maybridge4_001872 CC1(C)C(NC(=O)C2CCCCC2)[C@]3(C)CCC1C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F03 compound treatment 1.86254361E8 8330000.0 0.1 1.2517423E8 -7.08E7 -1.21 -0.7828 -0.6437 3179476 Maybridge4_001873 CCN(CC)c1ncc2c(NCc3ccccc3)nc(SCc4ccccc4)nc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F04 compound treatment 1.61102428E8 -1.68E7 -0.21 1.30641732E8 -6.53E7 -1.12 -0.9398 -0.826 1050962 Maybridge4_001874 NC(=O)CCCCC1CCSS1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F05 compound treatment 1.1705784E8 -6.09E7 -0.76 2.2691942E8 3.1E7 0.53 -0.1651 -0.1776 3179477 Maybridge4_001875 O=C(CN1CCc2ccccc12)Nc3scc4c3c(=O)oc5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F06 compound treatment 1.86426254E8 8500000.0 0.11 1.88593873E8 -7360000.0 -0.13 -0.0137 -0.0828 3063341 Maybridge4_001876 CC1(C)C2CCC1(C)c3noc(c23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F07 compound treatment 1.14269263E8 -6.37E7 -0.8 2.17796061E8 2.18E7 0.37 -0.3003 -0.3405 1040822 Maybridge4_001877 Cc1ccc(NC(=O)N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F08 compound treatment 1.25352474E8 -5.26E7 -0.66 2.27689539E8 3.17E7 0.54 -0.0822 -0.0962 1502018 Maybridge4_001878 COc1ccc2oc(cc(=O)c2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F09 compound treatment 8.7426382E7 -9.05E7 -1.14 1.31874181E8 -6.41E7 -1.1 -1.5784 -0.9999 3063363 Maybridge4_001879 O=C1/C(=C/c2ccc(cc2)c3nnn[nH]3)/C(Oc4ccccc14)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F10 compound treatment 1.8400102E8 6070000.0 0.08 2.020958E8 6140000.0 0.11 0.1282 0.9875 3063364 Maybridge4_001880 CC1(C)NC(=O)N(CC=C)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F11 compound treatment 1.34669297E8 -4.33E7 -0.54 2.2478372E8 2.88E7 0.49 -0.0347 -0.0473 3063365 Maybridge4_001881 Clc1ccccc1CNC(=S)NC2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F12 compound treatment 1.33001137E8 -4.49E7 -0.56 2.2369307E8 2.77E7 0.47 -0.0627 -0.0851 3063366 Maybridge4_001882 Fc1ccc(cc1)N(Cc2ccc(Br)cc2)C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F13 compound treatment 1.16791697E8 -6.11E7 -0.77 1.73021062E8 -2.29E7 -0.39 -0.8198 -0.9516 1687915 Maybridge4_001883 CC1(C)CC(=O)C=C(C1)Sc2nc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F14 compound treatment 2.04101235E8 2.62E7 0.33 2.02199248E8 6250000.0 0.11 0.3078 0.8913 3063367 Maybridge4_001884 C[n+]1ccc(CCc2cc[n+](C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F15 compound treatment 1.65217949E8 -1.27E7 -0.16 1.88909657E8 -7040000.0 -0.12 -0.198 -0.9905 1612566 Maybridge4_001885 CCC(=O)N1N(C(=O)CC)c2cc(Cl)ccc2-n3c1nn(C(=O)CC)c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F16 compound treatment 1.29561038E8 -4.84E7 -0.61 1.40458881E8 -5.55E7 -0.95 -1.1007 -0.9765 1406161 Maybridge4_001886 CC(=O)Oc1c(I)c(=O)n(C)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F17 compound treatment 2.05329441E8 2.74E7 0.34 1.80630425E8 -1.53E7 -0.26 0.0576 0.1333 3179478 Maybridge4_001887 CCSC(=O)NC1CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F18 compound treatment 1.80960381E8 3030000.0 0.04 2.10840125E8 1.49E7 0.25 0.2071 0.8038 3179479 Maybridge4_001888 C1C(=CC(=NN=C1c2ccccc2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F19 compound treatment 2.01219451E8 2.33E7 0.29 2.09727892E8 1.38E7 0.24 0.3734 0.9943 1002179 Maybridge4_001889 Clc1ccc(cc1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F20 compound treatment 1.88297385E8 1.04E7 0.13 2.01263474E8 5310000.0 0.09 0.1563 0.9847 3063368 Maybridge4_001890 CCC(C)Sc1nnc(S)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F21 compound treatment 1.78643072E8 716000.0 0.01 1.91339904E8 -4610000.0 -0.08 -0.0495 -0.6226 3179480 Maybridge4_001891 COC(=O)/C(=C/c1ccccc1)/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F22 compound treatment 2.02046637E8 2.41E7 0.3 1.53501369E8 -4.25E7 -0.73 -0.2999 -0.381 1172572 Maybridge4_001892 O=c1[nH]cc(NCc2ccccc2)c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F23 mock treatment 1.81639689E8 3710000.0 0.05 2.0367135E8 7720000.0 0.13 0.1264 0.902 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 F24 mock treatment 1.72877551E8 -5050000.0 -0.06 1.87150334E8 -8800000.0 -0.15 -0.1513 -0.9259 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G01 compound treatment 1.17984542E8 -5.99E7 -0.75 1.35886799E8 -6.01E7 -1.03 -1.2587 -0.9882 3179481 Maybridge4_001893 CCOC(=O)N1CCC(CC1)NC(=O)CCCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G02 compound treatment 1.61536556E8 -1.64E7 -0.21 1.38386301E8 -5.76E7 -0.99 -0.8422 -0.8366 3179482 Maybridge4_001894 O=C1CSC2=NC3=C(CCc4ccccc34)C(N12)c5cccs5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G03 compound treatment 1.75735376E8 -2190000.0 -0.03 1.57550584E8 -3.84E7 -0.66 -0.4843 -0.736 3063369 Maybridge4_001895 CCOC(=O)c1ncn(Cc2ccccc2)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G04 compound treatment 1.95061003E8 1.71E7 0.21 1.69879232E8 -2.61E7 -0.45 -0.1636 -0.3303 3063370 Maybridge4_001896 S=c1[nH]nc(Cn2nnc3ccccc23)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G05 compound treatment 2.04299069E8 2.64E7 0.33 1.86728142E8 -9220000.0 -0.16 0.1223 0.3336 3179483 Maybridge4_001897 COc1cccc(Cc2nnc(o2)c3ccc(s3)c4cccs4)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G06 compound treatment 1.79159874E8 1230000.0 0.02 1.6491373E8 -3.1E7 -0.53 -0.3648 -0.6862 3063371 Maybridge4_001898 Cn1nc2c3ccccc3n(Cc4ccccc4)c2nc1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G07 compound treatment 2.12638071E8 3.47E7 0.44 1.78360494E8 -1.76E7 -0.3 0.095 0.1794 3179484 Maybridge4_001899 CCOC(=O)c1cnn(C(=O)Cc2cccc(OC)c2)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G08 compound treatment 2.30326017E8 5.24E7 0.66 2.07682069E8 1.17E7 0.2 0.6068 0.8828 1696254 Maybridge4_001900 COc1cc(OC)c2nc(C)c3CCSc3c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G09 compound treatment 1.82091919E8 4170000.0 0.05 1.63185099E8 -3.28E7 -0.56 -0.3597 -0.6385 3179485 Maybridge4_001901 CC(=O)Nc1ccccc1OCC2CC(=NO2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G10 compound treatment 1.5611277E8 -2.18E7 -0.27 1.40287132E8 -5.57E7 -0.95 -0.8673 -0.8748 3179486 Maybridge4_001902 C1Sc2nnc(c3ccccc3)n2N=C1c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G11 compound treatment 1.88989663E8 1.11E7 0.14 1.69393581E8 -2.66E7 -0.45 -0.2233 -0.4698 3063373 Maybridge4_001903 S=c1nc(Nc2ccccc2)c3cnn(c4ccccc4)c3[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G12 compound treatment 1.80027497E8 2100000.0 0.03 1.48038116E8 -4.79E7 -0.82 -0.5613 -0.684 3179487 Maybridge4_001904 CN1CCN(CC1)c2ncc3c(=S)[nH]c(=S)[nH]c3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G13 compound treatment 1.66117953E8 -1.18E7 -0.15 1.42972034E8 -5.3E7 -0.91 -0.746 -0.8118 3063374 Maybridge4_001905 CCn1c(Sc2ncnc3c2sc4nc(C)cc(C)c43)nnc1c5cccs5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G14 compound treatment 1.92513286E8 1.46E7 0.18 1.61932845E8 -3.4E7 -0.58 -0.2824 -0.4626 3179488 Maybridge4_001906 CCOC(=O)N1CCc2c(C(=O)OCC)c(NC(=S)N3CCc4ccccc34)sc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G15 compound treatment 1.790877E8 1160000.0 0.01 1.58705076E8 -3.72E7 -0.64 -0.4405 -0.6908 3179489 Maybridge4_001907 CCNC(=S)N1N=C2C(CCc3ccccc23)C1c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G16 compound treatment 1.70783919E8 -7140000.0 -0.09 1.61675839E8 -3.43E7 -0.59 -0.4782 -0.8057 1303898 Maybridge4_001908 CC1=NN(C(=O)C1)c2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G17 compound treatment 1.50304234E8 -2.76E7 -0.35 1.36690539E8 -5.93E7 -1.01 -0.9623 -0.8977 3063375 Maybridge4_001909 CCOC(=O)C1=NN(C2N1CCc3cc(OC)c(OC)cc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G18 compound treatment 1.3922373E8 -3.87E7 -0.49 1.38127351E8 -5.78E7 -0.99 -1.0432 -0.9462 3179490 Maybridge4_001910 COc1cc(/C=C\2/N=C(N(C)C2=O)c3ccccc3)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G19 compound treatment 1.47895271E8 -3.0E7 -0.38 1.56673437E8 -3.93E7 -0.67 -0.7418 -0.9625 3063377 Maybridge4_001911 Cc1c(C)c(=O)n(Cc2ccc(Br)cc2)c(=O)n1Cc3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G20 compound treatment 1.51905515E8 -2.6E7 -0.33 1.50949135E8 -4.5E7 -0.77 -0.7755 -0.9269 3179491 Maybridge4_001912 O=C(Cn1nc2CSc3ccccc3-n2c1=O)NC(=O)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G21 compound treatment 1.51400583E8 -2.65E7 -0.33 1.59086407E8 -3.69E7 -0.63 -0.6815 -0.9553 3179492 Maybridge4_001913 CCOC(=O)c1sc2nc(C)cc(C)c2c1NC(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G22 compound treatment 1.60540161E8 -1.74E7 -0.22 1.61925348E8 -3.4E7 -0.58 -0.5661 -0.9102 1150256 Maybridge4_001914 N(c1ccccc1)c2ncnc3sc(cc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G23 mock treatment 1.53391123E8 -2.45E7 -0.31 1.56651671E8 -3.93E7 -0.67 -0.6933 -0.9372 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 G24 mock treatment 1.64798748E8 -1.31E7 -0.16 1.54269941E8 -4.17E7 -0.71 -0.621 -0.848 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H01 compound treatment 1.58840896E8 -1.91E7 -0.24 1.64135544E8 -3.18E7 -0.54 -0.5544 -0.9319 3179493 Maybridge4_001915 COc1cc(cc(OC)c1OC)c2nnc(SCC(=O)c3ccco3)n2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H02 compound treatment 1.44976584E8 -3.29E7 -0.41 1.52566162E8 -4.34E7 -0.74 -0.8174 -0.9617 1202312 Maybridge4_001916 Clc1ccc(OC2CN(C2)C(=O)N3CC(C3)Oc4ccc(Cl)cc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H03 compound treatment 1.60307703E8 -1.76E7 -0.22 1.21900487E8 -7.41E7 -1.27 -1.0526 -0.8181 3179494 Maybridge4_001917 O=C(CN1CCc2ccccc12)Nc3nnc(s3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H04 compound treatment 1.08417161E8 -6.95E7 -0.87 1.65474071E8 -3.05E7 -0.52 -0.9855 -0.9698 1178262 Maybridge4_001918 COc1ccc(cc1)c2nc3cc4Nc5ccccc5Oc4cc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H05 compound treatment 1.24828917E8 -5.31E7 -0.67 1.74070207E8 -2.19E7 -0.37 -0.7359 -0.9629 3063402 Maybridge4_001919 O=C(Nc1scc2c1c(=O)oc3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H06 compound treatment 1.15578737E8 -6.23E7 -0.78 1.45041708E8 -5.09E7 -0.87 -1.1693 -0.9985 3179495 Maybridge4_001920 FC(F)(F)C(NC(=O)c1cccnc1)(N2CCCC2=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H07 compound treatment 1.72215831E8 -5710000.0 -0.07 1.6264035E8 -3.33E7 -0.57 -0.4539 -0.7897 1117011 Maybridge4_001921 COc1cccc(NC(=O)N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H08 compound treatment 1.80542332E8 2620000.0 0.03 1.76236609E8 -1.97E7 -0.34 -0.2154 -0.6354 3063403 Maybridge4_001922 NC(=O)c1cc(Cl)c(Cl)cc1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H09 compound treatment 1.73178497E8 -4750000.0 -0.06 1.83829058E8 -1.21E7 -0.21 -0.1889 -0.8747 3179496 Maybridge4_001923 O[C@H]1[C@@H](Oc2ccccc2C1=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H10 compound treatment 1.15452593E8 -6.25E7 -0.78 1.67227913E8 -2.87E7 -0.49 -0.9018 -0.9748 3063404 Maybridge4_001924 COc1ncnc(OC)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H11 compound treatment 1.40116992E8 -3.78E7 -0.47 1.33599933E8 -6.24E7 -1.07 -1.0901 -0.9333 1558852 Maybridge4_001925 CC1=C(C(C2=C(N1)c3ccccc3C2=O)c4ccccc4)C(=O)Nc5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H12 compound treatment 1.18349941E8 -5.96E7 -0.75 1.73139199E8 -2.28E7 -0.39 -0.8046 -0.9542 1698244 Maybridge4_001926 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H13 compound treatment 1.69930079E8 -8000000.0 -0.1 1.66710994E8 -2.92E7 -0.5 -0.4249 -0.8323 1372400 Maybridge4_001927 O=c1c(c[nH]c2ccccc12)c3nnnn3c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H14 compound treatment 1.91380898E8 1.35E7 0.17 1.6997981E8 -2.6E7 -0.44 -0.195 -0.4101 3179497 Maybridge4_001928 N1[C@H]([C@H](N=C1c2ccccc2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H15 compound treatment 1.75469855E8 -2460000.0 -0.03 1.69907069E8 -2.6E7 -0.45 -0.337 -0.7542 3063405 Maybridge4_001929 CO[C@H]1O[C@H](COC(=O)c2ccccc2)[C@@H](O)[C@H](O)[C@H]1OC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H16 compound treatment 1.71135627E8 -6790000.0 -0.09 1.70137288E8 -2.58E7 -0.44 -0.3727 -0.8282 1081881 Maybridge4_001930 COC(=O)CSc1nc2ccccc2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H17 compound treatment 1.66865875E8 -1.11E7 -0.14 1.87110268E8 -8840000.0 -0.15 -0.2051 -0.9991 3063406 Maybridge4_001931 CC(C)N(C(C)C)C(=O)NCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H18 compound treatment 1.09442096E8 -6.85E7 -0.86 9.4251618E7 -1.02E8 -1.74 -1.8385 -0.947 3179498 Maybridge4_001932 Clc1ccc(cc1)c2nc(SCc3ccccc3)[nH]c(=S)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H19 compound treatment 1.60108809E8 -1.78E7 -0.22 1.60970162E8 -3.5E7 -0.6 -0.5815 -0.9097 3063407 Maybridge4_001933 OC(=O)c1cc(F)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H20 compound treatment 1.75891443E8 -2040000.0 -0.03 1.82316509E8 -1.36E7 -0.23 -0.1831 -0.7798 1198061 Maybridge4_001934 CC(Oc1ccc(Cl)cc1Cl)c2n[nH]c(=S)n2CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H21 compound treatment 1.69975864E8 -7950000.0 -0.1 1.64325131E8 -3.16E7 -0.54 -0.4533 -0.8235 3179499 Maybridge4_001935 FC(F)(F)C(NC1CCCCC1)(NC(=O)c2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H22 compound treatment 1.46729262E8 -3.12E7 -0.39 1.34884849E8 -6.11E7 -1.05 -1.0159 -0.9101 1345621 Maybridge4_001936 O=c1[nH][nH]c(=O)n1CCCc2cc3cccc4ccc5cccc2c5c43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H23 mock treatment 1.71497602E8 -6430000.0 -0.08 1.61200092E8 -3.48E7 -0.59 -0.4777 -0.7957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 H24 mock treatment 1.62446461E8 -1.55E7 -0.19 1.55293122E8 -4.07E7 -0.7 -0.6295 -0.8711 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I01 compound treatment 1.41433261E8 -3.65E7 -0.46 1.60257407E8 -3.57E7 -0.61 -0.7558 -0.9899 3179500 Maybridge4_001937 NC(=O)c1ccccc1NCC(=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I02 compound treatment 1.77466951E8 -460000.0 -0.01 1.75450611E8 -2.05E7 -0.35 -0.2522 -0.7186 1786031 Maybridge4_001938 S=c1[nH]nc(Cc2ccccc2)n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I03 compound treatment 1.71940722E8 -5990000.0 -0.08 1.85694867E8 -1.03E7 -0.18 -0.1773 -0.9282 1416652 Maybridge4_001939 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I04 compound treatment 1.65216436E8 -1.27E7 -0.16 1.57541017E8 -3.84E7 -0.66 -0.5777 -0.8538 3179586 Maybridge4_001940 CNC(=O)NC(=O)CSc1nnc(Cc2ccccc2)n1c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I05 compound treatment 1.93558888E8 1.56E7 0.2 1.94471539E8 -1480000.0 -0.03 0.1207 0.6106 3063409 Maybridge4_001941 Cn1cc(cn1)S(=O)(=O)Nc2ccc(Oc3c(Cl)cccc3Cl)nc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I06 compound treatment 2.15473784E8 3.75E7 0.47 2.09371583E8 1.34E7 0.23 0.4955 0.9455 3179587 Maybridge4_001942 Clc1ccccc1CC(C(=O)N2CCc3ccccc23)C(=O)N4CCc5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I07 compound treatment 2.09776071E8 3.18E7 0.4 1.96128698E8 177000.0 0.0 0.2847 0.7124 3063410 Maybridge4_001943 CCOC(=O)c1cnn(C(=O)c2ccc(cc2)n3c(C)ccc3C)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I08 compound treatment 2.1279294E8 3.49E7 0.44 2.03581861E8 7630000.0 0.13 0.4016 0.8799 1500802 Maybridge4_001944 NC(=O)c1nnc2ccc(Cl)cc2c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I09 compound treatment 1.83516656E8 5590000.0 0.07 2.08408151E8 1.25E7 0.21 0.2004 0.8926 1103360 Maybridge4_001945 FC(F)(F)c1ccc(cc1)C(=O)CN2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I10 compound treatment 1.73342744E8 -4580000.0 -0.06 2.28613389E8 3.27E7 0.56 0.3547 0.6311 3179588 Maybridge4_001946 O=C(CSc1nnc2NCCCn12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I11 compound treatment 2.19877209E8 4.2E7 0.53 2.60462622E8 6.45E7 1.1 1.153 0.9425 1721477 Maybridge4_001947 Cc1nn(c2NC3=C(C(c12)c4cccnc4)C(=O)CC(C)(C)C3)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I12 compound treatment 2.12545096E8 3.46E7 0.43 2.18333376E8 2.24E7 0.38 0.578 0.998 1444715 Maybridge4_001948 Cc1nc2cc(C)ccn2c1c3nnco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I13 compound treatment 1.83982426E8 6060000.0 0.08 2.48889556E8 5.29E7 0.91 0.6945 0.7637 3063411 Maybridge4_001949 Cc1cc(C)c(C#N)c(Sc2ncnc3c2sc4nc(C)cc(C)c43)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I14 compound treatment 1.9223299E8 1.43E7 0.18 2.24803966E8 2.89E7 0.49 0.4761 0.9061 3179589 Maybridge4_001950 COc1ccc(cc1)n2c(n[nH]c2=S)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I15 compound treatment 2.13206686E8 3.53E7 0.44 2.13076961E8 1.71E7 0.29 0.5202 0.98 3179590 Maybridge4_001951 CNC(=S)N1N=C2C(CCc3ccccc23)C1c4ccc(OC)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I16 compound treatment 1.98103371E8 2.02E7 0.25 2.1934489E8 2.34E7 0.4 0.4621 0.9755 3063412 Maybridge4_001952 CCOC(=O)N1CCc2c(C1)sc3[nH]c(=S)n(c4ccccc4)c(=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I17 compound treatment 2.03895594E8 2.6E7 0.33 2.18058777E8 2.21E7 0.38 0.4979 0.9972 3179591 Maybridge4_001953 COc1cc2CCn3c(C(=O)c4cccs4)c(c(C#N)c3-c2cc1OC)c5ccc(C)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I18 compound treatment 2.00653883E8 2.27E7 0.29 2.29269443E8 3.33E7 0.57 0.6049 0.9487 3063413 Maybridge4_001954 Fc1ccc(CN2C(=O)/C(=C\c3ccc(F)cc3)/N=C2c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I19 compound treatment 2.08675663E8 3.07E7 0.39 2.39010443E8 4.31E7 0.74 0.7939 0.9544 3179592 Maybridge4_001955 CCC(C)[C@H](NC(=O)c1ccco1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I20 compound treatment 2.47018E8 6.91E7 0.87 2.18460491E8 2.25E7 0.39 0.8853 0.9334 3179593 Maybridge4_001956 COc1cccc(c1)C(=O)c2sc3nsc(SCc4ccccc4)c3c2N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I21 compound treatment 2.24738271E8 4.68E7 0.59 2.12943384E8 1.7E7 0.29 0.6209 0.9475 3063414 Maybridge4_001957 Cc1cc(C)c2c(N)c(sc2n1)c3nnc(SCC(=O)c4ccccc4)n3CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I22 compound treatment 2.39168917E8 6.12E7 0.77 2.11459274E8 1.55E7 0.27 0.7309 0.8993 3179594 Maybridge4_001958 C=CCn1nc2CSc3ccccc3-n2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I23 mock treatment 2.20251672E8 4.23E7 0.53 2.17398772E8 2.14E7 0.37 0.635 0.9838 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 I24 mock treatment 2.13287469E8 3.54E7 0.44 2.1140183E8 1.54E7 0.26 0.5007 0.9695 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J01 compound treatment 1.90261989E8 1.23E7 0.15 2.02052789E8 6100000.0 0.1 0.1833 0.9817 3179595 Maybridge4_001959 CCOC(=O)CSc1nc(CN2c3ccccc3Sc4ccccc24)n[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J02 compound treatment 1.95311911E8 1.74E7 0.22 2.15204146E8 1.93E7 0.33 0.3872 0.9799 1402836 Maybridge4_001960 NS(=O)(=O)c1ccc(Cl)cc1Sc2ccccc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J03 compound treatment 1.34006294E8 -4.39E7 -0.55 1.71110762E8 -2.48E7 -0.43 -0.6903 -0.9918 3179596 Maybridge4_001961 CCOC(=O)Cn1c(nc(c1c2ccccc2)c3ccccc3)c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J04 compound treatment 1.95444745E8 1.75E7 0.22 2.16976246E8 2.1E7 0.36 0.4099 0.972 1114912 Maybridge4_001962 NNC(=O)CNC(=O)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J05 compound treatment 1.54435393E8 -2.35E7 -0.29 2.4142632E8 4.55E7 0.78 0.3421 0.411 3179597 Maybridge4_001963 Fc1ccc(COc2nc(cc(c3ccco3)c2C#N)c4cccs4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J06 compound treatment 2.24642041E8 4.67E7 0.59 2.06445311E8 1.05E7 0.18 0.5414 0.8833 3063348 Maybridge4_001964 FC(F)(F)C(NCc1ccccn1)(NC(=O)c2cccnc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J07 compound treatment 1.61287468E8 -1.66E7 -0.21 2.46610914E8 5.07E7 0.87 0.4656 0.522 3179598 Maybridge4_001965 COc1ccc(/N=C/c2cn(cc2\C=N\c3ccc(OC)cc3)c4ccc(OC)cc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J08 compound treatment 1.52988984E8 -2.49E7 -0.31 1.64791472E8 -3.12E7 -0.53 -0.5984 -0.9677 1550362 Maybridge4_001966 OC(=O)c1ccccc1NC(=O)OCC2c3ccccc3-c4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J09 compound treatment 1.59065088E8 -1.89E7 -0.24 1.6154018E8 -3.44E7 -0.59 -0.5838 -0.9197 3179599 Maybridge4_001967 CC1(C)CC(=O)C=C(C1)Sc2nc3cc(Cl)ccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J10 compound treatment 2.07208957E8 2.93E7 0.37 2.40906686E8 4.5E7 0.77 0.8039 0.9427 1156147 Maybridge4_001968 COc1ccc2nc3n(C)c(=O)n(C)c(=O)c3cc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J11 compound treatment 1.86116692E8 8190000.0 0.1 2.2457014E8 2.86E7 0.49 0.419 0.8372 3179600 Maybridge4_001969 O=C1C2=C(NC(=S)NC2c3ccccc3)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J12 compound treatment 1.6368356E8 -1.42E7 -0.18 2.04166083E8 8210000.0 0.14 -0.0269 -0.1184 1727811 Maybridge4_001970 COc1cc(CCC(C)NC(=O)c2ccco2)ccc1OC(=O)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J13 compound treatment 2.17574236E8 3.96E7 0.5 2.50885772E8 5.49E7 0.94 1.0166 0.9557 3063350 Maybridge4_001971 COc1ccc(C#N)cc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J14 compound treatment 1.97926771E8 2.0E7 0.25 2.09106247E8 1.32E7 0.23 0.3366 0.9985 1014022 Maybridge4_001972 O=S(=O)(Cc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J15 compound treatment 2.08881692E8 3.1E7 0.39 2.22235228E8 2.63E7 0.45 0.5927 0.9973 3179601 Maybridge4_001973 Nc1n/c(=N\c2ccccc2)/n(c3ccccc3)c(=N)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J16 compound treatment 2.06852929E8 2.89E7 0.36 2.1439409E8 1.84E7 0.32 0.4798 0.9976 3063351 Maybridge4_001974 FC(F)(F)c1ccccc1/N=C/2\CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J17 compound treatment 1.9348586E8 1.56E7 0.2 2.10970979E8 1.5E7 0.26 0.3198 0.9908 3179602 Maybridge4_001975 COCOc1ccc(cc1OC)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J18 compound treatment 2.23965722E8 4.6E7 0.58 2.08725796E8 1.28E7 0.22 0.563 0.9117 1465673 Maybridge4_001976 CC(Nc1ccccc1)(C#N)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J19 compound treatment 1.96561046E8 1.86E7 0.23 2.06647615E8 1.07E7 0.18 0.2948 0.9927 3179603 Maybridge4_001977 c1ccc(cc1)c2nnc(o2)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J20 compound treatment 1.77281827E8 -645000.0 -0.01 1.86781431E8 -9170000.0 -0.16 -0.1167 -0.7426 1519121 Maybridge4_001978 CC(Oc1ccccc1c2ccccc2)c3n[nH]c(=S)n3c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J21 compound treatment 1.9141597E8 1.35E7 0.17 2.05401062E8 9450000.0 0.16 0.234 0.9997 3063353 Maybridge4_001979 COC(NC(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J22 compound treatment 2.221507E8 4.42E7 0.55 2.06763759E8 1.08E7 0.19 0.5232 0.8945 1009264 Maybridge4_001980 CC(NC(=O)C)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J23 mock treatment 2.13958426E8 3.6E7 0.45 2.03050796E8 7100000.0 0.12 0.4055 0.8664 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 J24 mock treatment 1.99631499E8 2.17E7 0.27 1.99356826E8 3400000.0 0.06 0.2337 0.8395 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K01 compound treatment 6.9811283E7 -1.08E8 -1.36 1.11396804E8 -8.46E7 -1.45 -1.9825 -0.9995 3179604 Maybridge4_001981 OC(=O)CSCC(=O)N1CCCN(CC1)c2ccc(cn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K02 compound treatment 1.05275254E8 -7.27E7 -0.91 1.37344717E8 -5.86E7 -1.0 -1.3538 -0.9989 3063380 Maybridge4_001982 CCOC(=O)c1nnn2c1nc(SCC(=O)N)c3ccccc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K03 compound treatment 1.03239676E8 -7.47E7 -0.94 1.23367129E8 -7.26E7 -1.24 -1.5411 -0.9903 3179605 Maybridge4_001983 COc1ccc(NC(=O)c2ccc(CN3CCS(=O)(=O)CC3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K04 compound treatment 1.43559162E8 -3.44E7 -0.43 1.55891726E8 -4.01E7 -0.69 -0.7897 -0.975 3063381 Maybridge4_001984 CNC(=O)NC(=O)CSc1nnc(c2ccncc2)n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K05 compound treatment 1.44668671E8 -3.33E7 -0.42 1.59335185E8 -3.66E7 -0.63 -0.7382 -0.9804 3179606 Maybridge4_001985 S=C(NCC1CC(=NO1)c2ccccc2)NCc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K06 compound treatment 1.55571565E8 -2.24E7 -0.28 1.73160099E8 -2.28E7 -0.39 -0.4742 -0.9869 3179607 Maybridge4_001986 CCOc1nc-2c(Cc3ccccc32)c(c4ccco4)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K07 compound treatment 1.57904975E8 -2.0E7 -0.25 1.69274991E8 -2.67E7 -0.46 -0.5005 -0.9603 3063383 Maybridge4_001987 Sc1nnc(Cc2ccsc2)n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K08 compound treatment 4.06587498E8 2.29E8 2.87 4.82351845E8 2.86E8 4.9 5.4949 0.9674 3179608 Maybridge4_001988 O=c1[nH]c-2c(CCc3ccccc32)c(c1C#N)c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K09 compound treatment 1.15081453E8 -6.28E7 -0.79 1.49625972E8 -4.63E7 -0.79 -1.1182 -1.0 3063384 Maybridge4_001989 C=CCSc1c2CCCc2c(C#N)c3nc4ccccc4n13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K10 compound treatment 1.04965357E8 -7.3E7 -0.92 1.85439808E8 -1.05E7 -0.18 -0.7744 -0.8302 3179609 Maybridge4_001990 O=C(N1CCCn2c(SCc3ccccc3)nnc12)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K11 compound treatment 1.31314551E8 -4.66E7 -0.58 1.784043E8 -1.75E7 -0.3 -0.6259 -0.9521 3063386 Maybridge4_001991 CCNC(=S)Nc1sc2CC(C)CCc2c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K12 compound treatment 1.40832011E8 -3.71E7 -0.47 1.9147497E8 -4480000.0 -0.08 -0.3832 -0.8126 3179610 Maybridge4_001992 Cc1sc2nc3SCC(=Nn3c(=O)c2c1C)c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K13 compound treatment 1.31465481E8 -4.65E7 -0.58 1.79692393E8 -1.63E7 -0.28 -0.6089 -0.9428 3063387 Maybridge4_001993 CCOC(=O)c1oc2nc(cc(c3ccco3)c2c1N)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K14 compound treatment 8.6639606E7 -9.13E7 -1.15 2.11224413E8 1.53E7 0.26 -0.6249 -0.532 3179611 Maybridge4_001994 C1Sc2ccccc2-n3c(nnc13)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K15 compound treatment 1.3882087E8 -3.91E7 -0.49 2.1428618E8 1.83E7 0.31 -0.125 -0.2146 3179694 Maybridge4_001995 CCOC(=O)c1nnn2c1n(C)c(=O)c3ccccc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K16 compound treatment 1.40667778E8 -3.73E7 -0.47 1.81917216E8 -1.4E7 -0.24 -0.5004 -0.9521 3063389 Maybridge4_001996 O=c1c(nnc2sc3ccccc3n12)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K17 compound treatment 1.47899292E8 -3.0E7 -0.38 2.03979265E8 8030000.0 0.14 -0.1692 -0.422 3179695 Maybridge4_001997 CCOC(=O)C1=NN(C2C1c3cccc4cccc2c34)c5ccc(C)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K18 compound treatment 1.51936226E8 -2.6E7 -0.33 1.86807265E8 -9140000.0 -0.16 -0.3412 -0.9435 3063390 Maybridge4_001998 Clc1ccccc1/C=C\2/N=C(N(CC=C)C2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K19 compound treatment 1.49009048E8 -2.89E7 -0.36 1.85800011E8 -1.02E7 -0.17 -0.3794 -0.9432 3179696 Maybridge4_001999 O=C(NCC1COc2ccccc2O1)Nc3csc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K20 compound treatment 1.22604417E8 -5.53E7 -0.69 2.02875235E8 6920000.0 0.12 -0.4069 -0.578 3179697 Maybridge4_002000 CNC(=O)NC(=O)CSc1ncnc2sc(cc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K21 compound treatment 1.56126714E8 -2.18E7 -0.27 1.75715174E8 -2.02E7 -0.35 -0.4383 -0.9931 3063391 Maybridge4_002001 Cc1cc(C)c2c(N)c(sc2n1)c3nnc(SCc4ccc(Cl)cc4)n3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K22 compound treatment 1.63806345E8 -1.41E7 -0.18 1.79530347E8 -1.64E7 -0.28 -0.324 -0.9752 3179698 Maybridge4_002002 S=c1[nH]nc(CSc2nc(cn2c3ccccc3)c4ccccc4)n1c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K23 mock treatment 1.63915321E8 -1.4E7 -0.18 1.89648136E8 -6300000.0 -0.11 -0.2006 -0.9726 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 K24 mock treatment 1.78237101E8 311000.0 0.0 1.78220831E8 -1.77E7 -0.3 -0.2119 -0.698 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L01 compound treatment 1.3644627E8 -4.15E7 -0.52 1.67566357E8 -2.84E7 -0.49 -0.7115 -0.9994 3063422 Maybridge4_002003 CCOC(=O)CSc1nc(SCC(=O)OCC)c2c3CCCc3sc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L02 compound treatment 1.39285721E8 -3.86E7 -0.48 1.44959244E8 -5.1E7 -0.87 -0.96 -0.9615 1536081 Maybridge4_002004 OC(=O)c1ccccc1Sc2ccccc2S(=O)(=O)NC3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L03 compound treatment 1.48868954E8 -2.91E7 -0.36 1.74292165E8 -2.17E7 -0.37 -0.5199 -1.0 3179699 Maybridge4_002005 C=CCn1c(nc(c1c2ccccc2)c3ccccc3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L04 compound treatment 8.7499896E7 -9.04E7 -1.13 1.73389792E8 -2.26E7 -0.39 -1.0752 -0.8973 1430538 Maybridge4_002006 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L05 compound treatment 9.8107879E7 -7.98E7 -1.0 1.72685784E8 -2.33E7 -0.4 -0.9896 -0.9184 3179700 Maybridge4_002007 N=c1n(Nc2ccccc2)cnc3sc4CCCc4c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L06 compound treatment 1.45900606E8 -3.2E7 -0.4 1.68701918E8 -2.73E7 -0.47 -0.6139 -0.9972 3063426 Maybridge4_002008 Cc1ccc(cc1)C(=O)NC(NCc2ccco2)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L07 compound treatment 1.0667522E8 -7.13E7 -0.89 1.75951845E8 -2.0E7 -0.34 -0.8741 -0.9133 3179701 Maybridge4_002009 Brc1ccc(s1)c2ccc(Br)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L08 compound treatment 1.40237963E8 -3.77E7 -0.47 1.55852551E8 -4.01E7 -0.69 -0.8197 -0.9834 1371799 Maybridge4_002010 CCOC(=O)C(C)Oc1ccc2c(cc(=O)oc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L09 compound treatment 1.45047625E8 -3.29E7 -0.41 1.73695456E8 -2.23E7 -0.38 -0.561 -0.9992 1134767 Maybridge4_002011 C1C(=Cc2ccccc12)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L10 compound treatment 1.02644646E8 -7.53E7 -0.94 1.79081386E8 -1.69E7 -0.29 -0.872 -0.883 1364288 Maybridge4_002012 O=C(NC1CCN(CC1)C(=O)C2CCC2)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L11 compound treatment 1.40014698E8 -3.79E7 -0.48 1.68113903E8 -2.78E7 -0.48 -0.6732 -1.0 1570440 Maybridge4_002013 Oc1cc(Cc2ccccc2)cnc1CN3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L12 compound treatment 1.40085404E8 -3.78E7 -0.47 1.8435277E8 -1.16E7 -0.2 -0.4761 -0.9252 1227426 Maybridge4_002014 CC(C)C1CCC(C)CC1N(Cc2ccccc2)C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L13 compound treatment 1.47570527E8 -3.04E7 -0.38 1.70831584E8 -2.51E7 -0.43 -0.5733 -0.9982 1583701 Maybridge4_002015 N[C@@H](CO)CSCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L14 compound treatment 1.52234634E8 -2.57E7 -0.32 1.96509849E8 558000.0 0.01 -0.2211 -0.6859 1368346 Maybridge4_002016 COc1cc(CCc2cc(OC)c(C)cc2OC)c(OC)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L15 compound treatment 1.03010645E8 -7.49E7 -0.94 1.77991153E8 -1.8E7 -0.31 -0.8819 -0.8919 3063428 Maybridge4_002017 FC(F)(F)C(NC(=O)c1ccccc1)(Nc2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L16 compound treatment 1.68650429E8 -9280000.0 -0.12 1.98940919E8 2990000.0 0.05 -0.0461 -0.3627 1023708 Maybridge4_002018 COc1ccc(cc1)c2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L17 compound treatment 1.5504008E8 -2.29E7 -0.29 1.79800606E8 -1.62E7 -0.28 -0.3985 -0.9998 1344186 Maybridge4_002019 CC(=O)N1C(C(=O)NC1=S)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L18 compound treatment 1.14383808E8 -6.35E7 -0.8 1.99098927E8 3150000.0 0.05 -0.5256 -0.6578 3179703 Maybridge4_002020 CC(C)C(C)(Nc1ccccc1)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L19 compound treatment 1.54546651E8 -2.34E7 -0.29 1.7503196E8 -2.09E7 -0.36 -0.4606 -0.9951 1047316 Maybridge4_002021 OC(=O)c1ccc(s1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L20 compound treatment 1.54359986E8 -2.36E7 -0.3 1.86234147E8 -9720000.0 -0.17 -0.3267 -0.963 3179704 Maybridge4_002022 Brc1ccccc1C(=O)c2ccc-3c(c2)C(=O)c4ccccc43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L21 compound treatment 1.613359E8 -1.66E7 -0.21 1.90398414E8 -5550000.0 -0.1 -0.2144 -0.937 3063451 Maybridge4_002023 FC(F)(F)C(NC(=O)c1ccccc1)(OCc2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L22 compound treatment 1.62504307E8 -1.54E7 -0.19 1.80074609E8 -1.59E7 -0.27 -0.329 -0.9861 3179705 Maybridge4_002024 CCOC(=O)CSc1nncc(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L23 mock treatment 1.53170895E8 -2.48E7 -0.31 1.87845455E8 -8110000.0 -0.14 -0.3177 -0.9341 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 L24 mock treatment 1.67832834E8 -1.01E7 -0.13 1.81416038E8 -1.45E7 -0.25 -0.2655 -0.9509 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M01 compound treatment 7.4102608E7 -1.04E8 -1.3 1.18684395E8 -7.73E7 -1.32 -1.8562 -1.0 3063453 Maybridge4_002025 Cc1ccc(CNC(=O)Nc2ccccc2)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M02 compound treatment 1.26733384E8 -5.12E7 -0.64 1.56246786E8 -3.97E7 -0.68 -0.9347 -0.9996 3179706 Maybridge4_002026 CCOC(=O)c1nnn2c1nc(SCc3ccc(F)cc3)c4ccccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M03 compound treatment 1.08168634E8 -6.98E7 -0.88 1.40600251E8 -5.54E7 -0.95 -1.2888 -0.9992 3179707 Maybridge4_002027 O=C(Nc1ccc(OCc2ccccc2)cc1)OCC3CN(Cc4ccccc4)CCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M04 compound treatment 1.24262912E8 -5.37E7 -0.67 1.71673778E8 -2.43E7 -0.42 -0.7699 -0.9731 3063456 Maybridge4_002028 O=C(CC(C(=O)N1CCc2ccccc12)C(=O)N3CCc4ccccc34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M05 compound treatment 1.26995634E8 -5.09E7 -0.64 1.7855119E8 -1.74E7 -0.3 -0.6624 -0.9397 3179708 Maybridge4_002029 O=C(OCC1CC(=NO1)c2ccccc2)c3cccc(n3)C(=O)OCC4CC(=NO4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M06 compound treatment 7.2738507E7 -1.05E8 -1.32 1.86529173E8 -9420000.0 -0.16 -1.0471 -0.7877 3063457 Maybridge4_002030 CC1=Nn2c(Cn3nnc4ccccc34)nnc2SC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M07 compound treatment 1.24637735E8 -5.33E7 -0.67 1.86766155E8 -9190000.0 -0.16 -0.5839 -0.8502 3179709 Maybridge4_002031 C/C(=N\O)/C(C)(C)Nc1ccc(cc1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M08 compound treatment 1.04658949E8 -7.33E7 -0.92 1.25901872E8 -7.01E7 -1.2 -1.4978 -0.9914 3063458 Maybridge4_002032 O=C(Oc1cc(=O)oc2c3cccc4CCn(c(=O)c12)c43)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M09 compound treatment 9.0171658E7 -8.78E7 -1.1 1.62771339E8 -3.32E7 -0.57 -1.18 -0.9526 2096080 Maybridge4_002033 CCOC(=O)c1sc2n(c3ccccc3)c(=S)n(c4ccccc4)c(=O)c2c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M10 compound treatment 8.6490933E7 -9.14E7 -1.15 1.60839638E8 -3.51E7 -0.6 -1.2361 -0.9545 3179710 Maybridge4_002034 CCOC(=O)N1CCc2c(C#N)c(NC(=O)CN3CCc4ccccc34)sc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M11 compound treatment 9.4101796E7 -8.38E7 -1.05 1.91953011E8 -4000000.0 -0.07 -0.792 -0.7515 3063459 Maybridge4_002035 O=C(COc1nc(cc(c2cccs2)c1C#N)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M12 compound treatment 1.36850831E8 -4.11E7 -0.52 2.30759091E8 3.48E7 0.6 0.057 0.0723 3063460 Maybridge4_002036 O=c1n(CN2CCOCC2)nc3sc4ccccc4n3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M13 compound treatment 7.6558411E7 -1.01E8 -1.27 1.97655077E8 1700000.0 0.03 -0.8786 -0.6907 3179711 Maybridge4_002037 Nc1c(oc2nc(cc(c3cccs3)c12)c4ccco4)C(=O)c5ccc(Cl)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M14 compound treatment 1.07708329E8 -7.02E7 -0.88 1.83249143E8 -1.27E7 -0.22 -0.7766 -0.856 3063486 Maybridge4_002038 Cc1nc2n(ncc2c(=O)n1NC(=O)Nc3ccc(Cl)c(Cl)c3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M15 compound treatment 1.31279889E8 -4.66E7 -0.59 2.05009848E8 9060000.0 0.16 -0.3041 -0.5024 3179712 Maybridge4_002039 CCOC(=O)c1nnn2c1n(CC=C)c(=O)c3ccccc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M16 compound treatment 1.24954689E8 -5.3E7 -0.66 1.6916379E8 -2.68E7 -0.46 -0.7941 -0.9836 3063487 Maybridge4_002040 COC(=O)C1=C(C)N=C2SC(=C(N)N2C1c3cccs3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M17 compound treatment 1.23645983E8 -5.43E7 -0.68 1.83410775E8 -1.25E7 -0.21 -0.6333 -0.887 3179713 Maybridge4_002041 O=C/1NN=C(\C1=C\2/OC(=CS2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M18 compound treatment 1.34041882E8 -4.39E7 -0.55 1.95750365E8 -202000.0 0.0 -0.3917 -0.7115 3179714 Maybridge4_002042 Clc1ccc(CN2C(=O)/C(=C\c3cccs3)/N=C2c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M19 compound treatment 9.0585254E7 -8.73E7 -1.1 1.85055321E8 -1.09E7 -0.19 -0.9066 -0.8158 3063489 Maybridge4_002043 COc1ccc(cc1)n2ncc(NC(=O)N3CCOCC3)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M20 compound treatment 1.28532704E8 -4.94E7 -0.62 1.76331693E8 -1.96E7 -0.34 -0.6756 -0.9586 3179715 Maybridge4_002044 O=c1c(nc(nn1CN2CCOCC2)c3ccccc3)C(CN4CCOCC4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M21 compound treatment 1.50326606E8 -2.76E7 -0.35 2.03681251E8 7730000.0 0.13 -0.1513 -0.4081 3063490 Maybridge4_002045 Clc1ccccc1C2C3CCc4ccccc4C3=NN2C(=O)c5cccs5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M22 compound treatment 1.90298032E8 1.24E7 0.16 2.02931925E8 6980000.0 0.12 0.1942 0.9917 3179716 Maybridge4_002046 CCOC(=O)c1cnc(nc1N)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M23 mock treatment 1.71923945E8 -6000000.0 -0.08 1.9856857E8 2620000.0 0.04 -0.0216 -0.2462 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 M24 mock treatment 1.73120004E8 -4810000.0 -0.06 2.03777359E8 7830000.0 0.13 0.0521 0.3546 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N01 compound treatment 1.87633537E8 9710000.0 0.12 2.02726922E8 6770000.0 0.12 0.1681 0.9997 3063492 Maybridge4_002047 O=C1CSc2nnc(c3ccccc3)n12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N02 compound treatment 1.52861278E8 -2.51E7 -0.31 1.62403678E8 -3.35E7 -0.57 -0.6284 -0.9598 1229835 Maybridge4_002048 OC(=O)c1ccccc1Sc2ccccc2S(=O)(=O)NC3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N03 compound treatment 1.10414979E8 -6.75E7 -0.85 2.15913112E8 2.0E7 0.34 -0.3572 -0.3912 1256899 Maybridge4_002049 c1csc(c1)c2nc(c([nH]2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N04 compound treatment 1.64239556E8 -1.37E7 -0.17 1.91566333E8 -4390000.0 -0.08 -0.1745 -0.9312 3178130 Maybridge4_002050 CCCc1cc(O)nc(SC/C=C/c2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N05 compound treatment 8.6002996E7 -9.19E7 -1.15 1.73295521E8 -2.27E7 -0.39 -1.0896 -0.8956 3178131 Maybridge4_002051 CCNc1nc(SCC(=O)NC(=O)NCc2ccccc2)nc3sc4CN(C)CCc4c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N06 compound treatment 1.16034708E8 -6.19E7 -0.78 2.10316087E8 1.44E7 0.25 -0.3751 -0.4606 3063494 Maybridge4_002052 CC1CN=C(S1)N(C2CCCCC2)C(=O)Nc3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N07 compound treatment 1.62025268E8 -1.59E7 -0.2 1.98048748E8 2100000.0 0.04 -0.1157 -0.5707 3178132 Maybridge4_002053 Cc1ccc(OC(=O)OCSc2nnn[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N08 compound treatment 1.72536362E8 -5390000.0 -0.07 2.03630631E8 7680000.0 0.13 0.0451 0.3053 1423044 Maybridge4_002054 CC(Oc1ccc2c(cc(=O)oc2c1)c3ccccc3)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N09 compound treatment 1.30712638E8 -4.72E7 -0.59 2.10003595E8 1.41E7 0.24 -0.2487 -0.3891 1177114 Maybridge4_002055 Brc1ccc(cc1)N2C(=O)C3=C(C2=O)C(=NCCN3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N10 compound treatment 1.74211066E8 -3720000.0 -0.05 2.43691045E8 4.77E7 0.82 0.5449 0.6657 1659522 Maybridge4_002056 Clc1cccc(Cl)c1C(=O)N2CCC(CC2)NC(=O)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N11 compound treatment 1.50137278E8 -2.78E7 -0.35 2.27120235E8 3.12E7 0.53 0.1308 0.2052 1381385 Maybridge4_002057 CN1C(=O)N(c2ccc(Cl)cc2)C(C)(O)CC1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N12 compound treatment 1.27303819E8 -5.06E7 -0.64 1.99946161E8 3990000.0 0.07 -0.4007 -0.6274 1409714 Maybridge4_002058 COc1cccc(NC(=O)c2ccc(OC)c(OC)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N13 compound treatment 1.91194917E8 1.33E7 0.17 2.18825405E8 2.29E7 0.39 0.3946 0.9274 1704266 Maybridge4_002059 CC(C)(C)C(=O)Nc1ccccc1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N14 compound treatment 2.06645598E8 2.87E7 0.36 2.43824993E8 4.79E7 0.82 0.8342 0.9319 3178133 Maybridge4_002060 NNC(=O)c1cc(S)ncn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N15 compound treatment 2.01273315E8 2.33E7 0.29 2.27459343E8 3.15E7 0.54 0.5885 0.9588 3063524 Maybridge4_002061 CC(=O)NC(Nc1ccccc1)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N16 compound treatment 1.21585751E8 -5.63E7 -0.71 2.30763044E8 3.48E7 0.6 -0.0784 -0.0848 3178134 Maybridge4_002062 C/C(=N\c1ccccc1C(F)(F)F)/c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N17 compound treatment 1.85927702E8 8000000.0 0.1 2.1693742E8 2.1E7 0.36 0.325 0.8713 1020871 Maybridge4_002063 O=C1NC(C(=O)N1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N18 compound treatment 1.74474907E8 -3450000.0 -0.04 1.98497785E8 2550000.0 0.04 2.0E-4 0.0032 1667495 Maybridge4_002064 Clc1ccc2[nH]c(=O)c3nc(oc3c2c1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N19 compound treatment 1.90053504E8 1.21E7 0.15 2.19189315E8 2.32E7 0.4 0.3888 0.913 1670169 Maybridge4_002065 CC(C)c1ccc(cc1)S(=O)(=O)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N20 compound treatment 2.12647562E8 3.47E7 0.44 2.04515173E8 8560000.0 0.15 0.4116 0.8957 1596128 Maybridge4_002066 CCOC(=O)C1CCN(C1=O)S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N21 compound treatment 1.70782211E8 -7140000.0 -0.09 2.08915985E8 1.3E7 0.22 0.0935 0.3909 1008385 Maybridge4_002067 O=C(c1ccccc1)c2ccccc2C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N22 compound treatment 1.78256212E8 330000.0 0.0 2.08070929E8 1.21E7 0.21 0.1496 0.7211 1546853 Maybridge4_002068 Cn1c(=O)n(C)c2ncn(CC(O)CN(CC=C)CC=C)c2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N23 mock treatment 1.73030508E8 -4900000.0 -0.06 2.12516729E8 1.66E7 0.28 0.1571 0.5414 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 N24 mock treatment 1.75329824E8 -2600000.0 -0.03 2.0085846E8 4910000.0 0.08 0.0364 0.4036 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O01 compound treatment 1.02452554E8 -7.55E7 -0.95 1.37908091E8 -5.8E7 -0.99 -1.3721 -0.9997 3063527 Maybridge4_002069 O=C(Nc1sccc1c2nc3ccccc3s2)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O02 compound treatment 1.08190059E8 -6.97E7 -0.87 1.2820843E8 -6.77E7 -1.16 -1.4386 -0.9903 3178135 Maybridge4_002070 CCOC(=O)CSc1nnc(Cn2nnc3ccccc23)n1c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O03 compound treatment 1.1570108E8 -6.22E7 -0.78 1.31351407E8 -6.46E7 -1.11 -1.3339 -0.9855 3063528 Maybridge4_002071 Cc1ccc(cc1)S(=O)(=O)NC(=O)OCC2CN(Cc3ccccc3)CCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O04 compound treatment 1.17702121E8 -6.02E7 -0.76 1.45920468E8 -5.0E7 -0.86 -1.1398 -0.998 3178136 Maybridge4_002072 Cn1nc2c3ccccc3n(CC=C)c2nc1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O05 compound treatment 1.14005293E8 -6.39E7 -0.8 1.40646687E8 -5.53E7 -0.95 -1.2364 -0.9966 3178137 Maybridge4_002073 Clc1ccc(cc1)n2ncc(n2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O06 compound treatment 1.07027708E8 -7.09E7 -0.89 1.21999999E8 -7.4E7 -1.27 -1.524 -0.9851 3178138 Maybridge4_002074 Brc1ccc(cc1)C2=Nn3c(Cn4nnc5ccccc45)nnc3SC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O07 compound treatment 1.16711095E8 -6.12E7 -0.77 1.38973292E8 -5.7E7 -0.98 -1.2327 -0.993 1760428 Maybridge4_002075 O=C(Nc1ccc2OCCOc2c1)c3ccc4nccnc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O08 compound treatment 1.18125839E8 -5.98E7 -0.75 1.4009513E8 -5.59E7 -0.96 -1.2066 -0.9928 3178139 Maybridge4_002076 CNC(=O)NC(=O)CSc1nnc(o1)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O09 compound treatment 9.8692306E7 -7.92E7 -0.99 1.37266587E8 -5.87E7 -1.0 -1.4132 -1.0 3178140 Maybridge4_002077 CCOC(=O)COc1c(C#N)sc2n(c3ccccc3)c(=S)n(c4ccccc4)c(=O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O10 compound treatment 1.05607135E8 -7.23E7 -0.91 1.40736435E8 -5.52E7 -0.95 -1.3098 -0.9998 3063548 Maybridge4_002078 S=c1[nH]c(=S)c2cnc(nc2[nH]1)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O11 compound treatment 1.05772906E8 -7.22E7 -0.91 1.46652887E8 -4.93E7 -0.84 -1.2368 -0.9994 1200067 Maybridge4_002079 Cc1cc(C)c2c(N)c(sc2n1)C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O12 compound treatment 1.01288381E8 -7.66E7 -0.96 1.34995012E8 -6.1E7 -1.04 -1.4176 -0.9992 2102976 Maybridge4_002080 COc1ccc(cc1)C2=Nn3c(SC2)nc4sc5CCCCc5c4c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O13 compound treatment 7.7181838E7 -1.01E8 -1.26 1.16317914E8 -7.96E7 -1.36 -1.8575 -0.9993 3063550 Maybridge4_002081 Cc1cc(C)c(C#N)c(Sc2ncnc3n(Cc4ccccc4)nnc23)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O14 compound treatment 1.05006826E8 -7.29E7 -0.91 1.44148439E8 -5.18E7 -0.89 -1.2739 -0.9999 3178141 Maybridge4_002082 O=c1n(/N=C/c2cccs2)cnc3sc(cc13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O15 compound treatment 1.04529123E8 -7.34E7 -0.92 1.43009594E8 -5.29E7 -0.91 -1.2919 -1.0 3178142 Maybridge4_002083 CCOC(=O)c1nnn2c1n(Cc3ccc(Cl)cc3)c(=O)c4ccccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O16 compound treatment 8.8971858E7 -8.9E7 -1.12 1.19164572E8 -7.68E7 -1.31 -1.7185 -0.9967 3063551 Maybridge4_002084 COc1cc(/C=N/n2c(C)nc3n(cnc3c2=O)c4ccccc4)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O17 compound treatment 1.17345444E8 -6.06E7 -0.76 1.57200131E8 -3.88E7 -0.66 -1.0064 -0.9977 3178143 Maybridge4_002085 O=c1nc2n(nc(c3ccccc3)n2c(c1C#N)c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O18 compound treatment 1.24938539E8 -5.3E7 -0.66 1.55780129E8 -4.02E7 -0.69 -0.9563 -0.9999 3063552 Maybridge4_002086 C1Cc2ccccc2N1c3ncnc4sc(cc34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O19 compound treatment 1.08986225E8 -6.89E7 -0.86 1.34954221E8 -6.1E7 -1.04 -1.3499 -0.9956 3178144 Maybridge4_002087 COc1ccc(cc1)n2ncc(NC(=O)Nc3ccc4OCCCOc4c3)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O20 compound treatment 1.25077418E8 -5.28E7 -0.66 1.54881316E8 -4.11E7 -0.7 -0.9659 -0.9996 3063553 Maybridge4_002088 Nc1ncnc2nc(ncc12)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O21 compound treatment 1.24758043E8 -5.32E7 -0.67 1.42731786E8 -5.32E7 -0.91 -1.1158 -0.9883 3178145 Maybridge4_002089 CC(=O)N1N=C2C(CCc3ccccc23)C1c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O22 compound treatment 1.3766909E8 -4.03E7 -0.51 1.55876885E8 -4.01E7 -0.69 -0.8422 -0.9886 3063554 Maybridge4_002090 Cc1cc(=O)n2ncnc2n1CC(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O23 mock treatment 1.39758217E8 -3.82E7 -0.48 1.45399935E8 -5.06E7 -0.87 -0.9505 -0.9611 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 O24 mock treatment 1.54293706E8 -2.36E7 -0.3 1.48764137E8 -4.72E7 -0.81 -0.7808 -0.9074 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P01 compound treatment 1.55350632E8 -2.26E7 -0.28 1.4963564E8 -4.63E7 -0.79 -0.7609 -0.9038 1504248 Maybridge4_002091 C1Cc2ccccc2N1c3ncnc4n(ncc34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P02 compound treatment 1.25962076E8 -5.2E7 -0.65 1.15083496E8 -8.09E7 -1.38 -1.4398 -0.941 1485949 Maybridge4_002092 CC(CN1CCN(Cc2ccccc2)CC1)N(C(=O)c3ccc(cc3)C(C)(C)C)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P03 compound treatment 1.35953831E8 -4.2E7 -0.53 1.33727305E8 -6.22E7 -1.07 -1.1255 -0.9472 3063615 Maybridge4_002093 O=C/1NNC(=N\C1=C/c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P04 compound treatment 1.68486513E8 -9440000.0 -0.12 1.41029919E8 -5.49E7 -0.94 -0.7485 -0.7899 3178146 Maybridge4_002094 Cn1cnnc1Sc2cc(C#N)c(C#N)cc2Sc3nncn3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P05 compound treatment 8.5102602E7 -9.28E7 -1.16 1.19939543E8 -7.6E7 -1.3 -1.7435 -0.9985 3063618 Maybridge4_002095 CCNc1nc(SCc2ccc(Cl)cc2)nc3sc4CN(C)CCc4c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P06 compound treatment 9.7020196E7 -8.09E7 -1.01 1.55207514E8 -4.07E7 -0.7 -1.2108 -0.9832 3178147 Maybridge4_002096 Cn1cnc(c1C#N)n2oo2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P07 compound treatment 1.29166128E8 -4.88E7 -0.61 1.67351223E8 -2.86E7 -0.49 -0.7787 -0.9939 1405262 Maybridge4_002097 O=C(NCc1ccccc1)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P08 compound treatment 1.62659483E8 -1.53E7 -0.19 1.39712769E8 -5.62E7 -0.96 -0.8162 -0.8315 1585718 Maybridge4_002098 CCOC(=O)C(C)Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P09 compound treatment 1.30506052E8 -4.74E7 -0.59 1.42925042E8 -5.3E7 -0.91 -1.0625 -0.979 3178148 Maybridge4_002099 COC(=O)/C(=C/C(=O)c1c(F)c(F)c(OC)c(F)c1F)/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P10 compound treatment 1.525122E8 -2.54E7 -0.32 1.60230124E8 -3.57E7 -0.61 -0.6578 -0.9539 1497616 Maybridge4_002100 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)C3CCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P11 compound treatment 9.4546687E7 -8.34E7 -1.05 1.55452666E8 -4.05E7 -0.69 -1.2298 -0.9801 3178149 Maybridge4_002101 O=c1ccc2CCCCc2n1CCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P12 compound treatment 1.51818643E8 -2.61E7 -0.33 1.56764506E8 -3.92E7 -0.67 -0.7059 -0.9457 1054556 Maybridge4_002102 Cc1ccc(NS(=O)(=O)c2ccccc2)c(NS(=O)(=O)c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P13 compound treatment 1.5697758E8 -2.09E7 -0.26 1.48018624E8 -4.79E7 -0.82 -0.766 -0.8891 1043550 Maybridge4_002103 OC1CCN(Cc2ccccc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P14 compound treatment 1.49026995E8 -2.89E7 -0.36 1.47545851E8 -4.84E7 -0.83 -0.8423 -0.9312 1240290 Maybridge4_002104 CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P15 compound treatment 1.59180952E8 -1.87E7 -0.24 1.51866502E8 -4.41E7 -0.75 -0.6999 -0.8855 3063648 Maybridge4_002105 CC(=O)NC(NCc1ccccc1)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P16 compound treatment 1.60006701E8 -1.79E7 -0.22 1.49845177E8 -4.61E7 -0.79 -0.717 -0.8738 3178234 Maybridge4_002106 CC(C)[C@H]1COC(=N1)c2cccc(n2)C3=N[C@H](CO3)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P17 compound treatment 1.56731589E8 -2.12E7 -0.27 1.47305066E8 -4.86E7 -0.83 -0.7768 -0.8887 3063650 Maybridge4_002107 CC(O)/C=C/c1cccc[n+]1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P18 compound treatment 1.63103362E8 -1.48E7 -0.19 1.5386507E8 -4.21E7 -0.72 -0.6409 -0.8614 3178235 Maybridge4_002108 CCOC(=O)C1=C(C)N(C(=O)Oc2ccccc2)C(=NC1c3ccccc3)SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P19 compound treatment 1.51758526E8 -2.62E7 -0.33 1.50702546E8 -4.52E7 -0.77 -0.7798 -0.927 3063651 Maybridge4_002109 CN1C(=O)/C(=C\Nc2ccc(Cl)cc2)/C(=O)c3c1n(C)c(=O)n(C)c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P20 compound treatment 1.46455395E8 -3.15E7 -0.39 1.56209419E8 -3.97E7 -0.68 -0.7602 -0.9665 1466385 Maybridge4_002110 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OC)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P21 compound treatment 1.27491391E8 -5.04E7 -0.63 1.38673222E8 -5.73E7 -0.98 -1.1407 -0.9775 1646281 Maybridge4_002111 COc1cccc(c1)c2ncc(o2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P22 compound treatment 1.49653453E8 -2.83E7 -0.35 1.44707018E8 -5.12E7 -0.88 -0.8711 -0.9206 1592521 Maybridge4_002112 O=C(Nc1ccccc1)N(Cc2ccccc2)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P23 mock treatment 1.4561756E8 -3.23E7 -0.41 1.48504967E8 -4.74E7 -0.81 -0.8609 -0.9484 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2054 P24 mock treatment 1.4929292E8 -2.86E7 -0.36 1.58562617E8 -3.74E7 -0.64 -0.7066 -0.9627 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A01 compound treatment 2.24061609E8 4.69E7 0.59 2.18748008E8 4.68E7 0.8 0.9825 0.9886 3178236 Maybridge4_002113 CCOC(=O)c1c(C)n[nH]c1/N=C/c2ccc(OC)c(OC)c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A02 compound treatment 2.33517542E8 5.64E7 0.71 2.36834766E8 6.49E7 1.11 1.2853 0.9763 3178237 Maybridge4_002114 CS/C(=C(/C#N)\S(=O)(=O)c1ccc(Cl)cc1)/NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A03 compound treatment 2.39350842E8 6.22E7 0.78 2.2878842E8 5.68E7 0.97 1.2397 0.9941 1739670 Maybridge4_002115 O=C(C(C(=O)N1CCCCC1)C2(CC3CC4CC(C3)C2)C4)N5CCCCC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A04 compound treatment 2.4447581E8 6.74E7 0.84 2.42044639E8 7.01E7 1.2 1.4456 0.9853 3178238 Maybridge4_002116 CSc1c(C#N)c(nn1C)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A05 compound treatment 2.49098241E8 7.2E7 0.9 2.43342657E8 7.14E7 1.22 1.5023 0.9889 3063681 Maybridge4_002117 CN(C)c1nc(O)nc(n1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A06 compound treatment 2.43669902E8 6.66E7 0.83 2.3857847E8 6.66E7 1.14 1.3965 0.9883 3178239 Maybridge4_002118 CN1c2ccccc2C(=O)/C(=C\Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)/S1(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A07 compound treatment 2.47360968E8 7.02E7 0.88 2.38954596E8 6.7E7 1.15 1.4338 0.9915 1532269 Maybridge4_002119 COc1cc2CCN=C(c3ccccc3NC(=O)c4cccc(Cl)c4)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A08 compound treatment 2.24846705E8 4.77E7 0.6 2.23816332E8 5.18E7 0.89 1.0508 0.9817 1424615 Maybridge4_002120 CCCS(=O)(=O)C1=C(N)OC(=C(C#N)C1c2ccc(Cl)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A09 compound treatment 2.40098108E8 6.3E7 0.79 2.31606384E8 5.96E7 1.02 1.2804 0.992 1227957 Maybridge4_002121 Cc1cc(N(S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)n(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A10 compound treatment 2.51316021E8 7.42E7 0.93 2.34981449E8 6.3E7 1.08 1.4208 0.9973 3063685 Maybridge4_002122 CS/C(=C(/C#N)\C(=O)c1ccc(Cl)cc1)/NCC2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A11 compound treatment 2.41827528E8 6.47E7 0.81 2.25978505E8 5.4E7 0.92 1.2276 0.9979 1505422 Maybridge4_002123 O=C(Nc1cc(nn1c2ccccc2)C3CC3)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A12 compound treatment 2.56917228E8 7.98E7 1.0 2.25788449E8 5.38E7 0.92 1.3592 0.9991 3063686 Maybridge4_002124 CC(C)S(=O)(=O)/C(=C/Nc1ncccn1)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A13 compound treatment 2.25964594E8 4.88E7 0.61 2.04679176E8 3.27E7 0.56 0.8291 0.999 1730851 Maybridge4_002125 Cc1ccc(cc1)C2C(=C(N)OC(=C2C#N)C3CC3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A14 compound treatment 2.29485936E8 5.24E7 0.66 2.29014615E8 5.7E7 0.98 1.1549 0.9814 3063688 Maybridge4_002126 Cn1ccnc1S(=O)(=O)/C(=C/c2ccc3OCOc3c2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A15 compound treatment 2.25999738E8 4.89E7 0.61 2.27134424E8 5.52E7 0.94 1.1012 0.9782 1337308 Maybridge4_002127 CCOC(=O)c1cnc2n(C)nc(C3CC3)c2c1N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A16 compound treatment 2.32898529E8 5.58E7 0.7 2.32011602E8 6.0E7 1.03 1.2214 0.9825 3063690 Maybridge4_002128 Cc1cc(nc2c(Br)c(nn12)C(C)(C)C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A17 compound treatment 2.24144407E8 4.7E7 0.59 2.47259945E8 7.53E7 1.29 1.3284 0.9373 1574781 Maybridge4_002129 COc1c(Cl)scc1NC(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A18 compound treatment 1.93253938E8 1.61E7 0.2 1.90779187E8 1.88E7 0.32 0.3707 0.975 3063692 Maybridge4_002130 CSC(=C(C#N)C(=O)c1cccc(c1)C(F)(F)F)SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A19 compound treatment 2.17617788E8 4.05E7 0.51 2.03235506E8 3.13E7 0.54 0.7376 0.9997 3178240 Maybridge4_002131 Clc1ccccc1C(=O)C(=C2SCCCS2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A20 compound treatment 2.41383742E8 6.43E7 0.81 2.28542417E8 5.66E7 0.97 1.2547 0.9959 1150123 Maybridge4_002132 CC(C)CC(NC(=O)Cc1ccsc1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A21 compound treatment 1.66398705E8 -1.07E7 -0.13 2.33861381E8 6.19E7 1.06 0.654 0.6124 3063728 Maybridge4_002133 COc1cccc(c1)c2nc(N)nc(SC)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A22 compound treatment 2.28619362E8 5.15E7 0.65 2.2646694E8 5.45E7 0.93 1.1164 0.9839 3178241 Maybridge4_002134 Fc1ccc(N/C=C(\C#N)/S(=O)(=O)Cc2ccco2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A23 mock treatment 2.10851229E8 3.37E7 0.42 2.20532287E8 4.86E7 0.83 0.8869 0.951 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 A24 mock treatment 2.29277681E8 5.22E7 0.65 2.37046182E8 6.51E7 1.11 1.2503 0.9678 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B01 compound treatment 2.29068177E8 5.19E7 0.65 2.31235213E8 5.93E7 1.01 1.1781 0.9771 3178242 Maybridge4_002135 FC(F)(F)c1cc(CN/C=C(\C#N)/S(=O)(=O)Cc2ccco2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B02 compound treatment 2.52886797E8 7.58E7 0.95 2.37445685E8 6.55E7 1.12 1.4645 0.9966 3063731 Maybridge4_002136 COC(=O)c1ccc2C(=O)/C(=C/Nc3ccc(Cl)cc3)/S(=O)(=O)N(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B03 compound treatment 2.42016794E8 6.49E7 0.81 2.26628784E8 5.47E7 0.94 1.2372 0.9976 3178243 Maybridge4_002137 CSc1sc(/C(=N\O)/C)c2CC(C)(C)C/C(=N/O)/c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B04 compound treatment 2.48208051E8 7.11E7 0.89 2.547448E8 8.28E7 1.42 1.6324 0.9751 3063732 Maybridge4_002138 COC(=O)c1sc(SC)c(c1C)c2ccon2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B05 compound treatment 2.58077123E8 8.1E7 1.02 2.34162767E8 6.22E7 1.06 1.4708 0.9997 3178244 Maybridge4_002139 Clc1ccc(Sc2ccccc2CN/C(=C(\N=C\c3cccs3)/C#N)/C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B06 compound treatment 2.10506047E8 3.34E7 0.42 2.22750815E8 5.08E7 0.87 0.9107 0.944 3063733 Maybridge4_002140 CN(C)/C=C/C(=O)c1ccc2OC(C)(C)CCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B07 compound treatment 2.60928175E8 8.38E7 1.05 2.3006005E8 5.81E7 0.99 1.4464 0.9996 1330787 Maybridge4_002141 Clc1ccc(cc1)C(=O)N(CCS(=O)(=O)c2ccc(Cl)cc2)Cc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B08 compound treatment 1.75244603E8 -1880000.0 -0.02 2.29603008E8 5.76E7 0.99 0.6809 0.69 3063734 Maybridge4_002142 Clc1ccc(cc1)S(=O)(=O)C(=C2SCCCCS2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B09 compound treatment 2.46772576E8 6.97E7 0.87 2.35435867E8 6.35E7 1.09 1.386 0.9942 1191188 Maybridge4_002143 CSc1scc2CCc3cn(nc3-c12)C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B10 compound treatment 1.57332786E8 -1.98E7 -0.25 2.48093318E8 7.61E7 1.3 0.7458 0.5623 1483249 Maybridge4_002144 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B11 compound treatment 2.58312778E8 8.12E7 1.02 2.45189799E8 7.32E7 1.25 1.6064 0.9947 3178245 Maybridge4_002145 Cc1csc2sc(C(=O)c3ccc(Cl)cc3)c(C)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B12 compound treatment 2.55885944E8 7.88E7 0.99 2.45488038E8 7.35E7 1.26 1.5885 0.9928 3063735 Maybridge4_002146 FC(F)(F)c1cc(n2ncc(C(=O)NC(=S)Nc3ccccc3Cl)c2n1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B13 compound treatment 2.41017169E8 6.39E7 0.8 2.2623858E8 5.43E7 0.93 1.2236 0.9973 1629969 Maybridge4_002147 CCOC(=O)c1sc(SC)c-2c1CCc3cnc(SC)nc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B14 compound treatment 2.39181202E8 6.21E7 0.78 2.29365744E8 5.74E7 0.98 1.2451 0.9934 3178246 Maybridge4_002148 CC(C)CSc1nnc(CSCc2nc(cs2)c3ccc(Cl)cc3)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B15 compound treatment 2.16433806E8 3.93E7 0.49 2.29014623E8 5.7E7 0.98 1.0391 0.95 1122221 Maybridge4_002149 Clc1ccc(cc1)C2CC(=CC(=S)S2)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B16 compound treatment 2.41510302E8 6.44E7 0.81 2.57843395E8 8.59E7 1.47 1.6105 0.9602 3063769 Maybridge4_002150 NNC(=O)c1ccc(CSc2ccc(cn2)C(F)(F)F)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B17 compound treatment 2.55528277E8 7.84E7 0.98 2.6043454E8 8.85E7 1.51 1.7662 0.9782 3178247 Maybridge4_002151 COC(=O)C1=C(CSC1)Nc2ccc(OC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B18 compound treatment 2.45540488E8 6.84E7 0.86 2.42638851E8 7.07E7 1.21 1.4622 0.9859 3063773 Maybridge4_002152 CC(C)(C)SC(=O)c1cccnc1SCCS(=O)(=O)c2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B19 compound treatment 2.28795842E8 5.17E7 0.65 1.62002149E8 -9980000.0 -0.17 0.3376 0.5037 3178248 Maybridge4_002153 Cc1csc2sc(/C=N/Cc3cccs3)c(C)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B20 compound treatment 2.16533939E8 3.94E7 0.49 2.32578141E8 6.06E7 1.04 1.0831 0.9425 1206852 Maybridge4_002154 CCOC(=O)c1cnc2n(C)nc(C)c2c1Sc3nnc(SC)s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B21 compound treatment 2.57447128E8 8.03E7 1.01 2.47340228E8 7.54E7 1.29 1.6247 0.9925 3178249 Maybridge4_002155 CS(=O)(=O)c1sc(C(=O)NC(=S)Nc2ccc(OC(F)(F)F)cc2)c3CCC=Cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B22 compound treatment 1.51797005E8 -2.53E7 -0.32 2.05465356E8 3.35E7 0.57 0.1807 0.2758 3178341 Maybridge4_002156 CCOC(=O)CC1Sc2ccccc2N=C1SCC(=O)Nc3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B23 mock treatment 2.44297742E8 6.72E7 0.84 2.27583667E8 5.56E7 0.95 1.269 0.9982 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 B24 mock treatment 2.36797177E8 5.97E7 0.75 2.21219744E8 4.92E7 0.84 1.1254 0.9982 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C01 compound treatment 1.79772507E8 2650000.0 0.03 1.62134402E8 -9840000.0 -0.17 -0.0956 -0.5567 3063777 Maybridge4_002157 CCN(CC)C(=S)NC(=S)c1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C02 compound treatment 1.87896357E8 1.08E7 0.14 1.7234333E8 366000.0 0.01 0.1 0.739 3178342 Maybridge4_002158 COC(=O)c1ccccc1S(=O)(=O)/C(=C/Nc2nc(C)cc(C)n2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C03 compound treatment 1.88039129E8 1.09E7 0.14 1.67087982E8 -4890000.0 -0.08 0.0377 0.2347 1199477 Maybridge4_002159 CN(C1CCS(=O)(=O)C1)C(=O)COc2ccc(Oc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C04 compound treatment 9.5045006E7 -8.21E7 -1.03 7.4088638E7 -9.79E7 -1.68 -1.9129 -0.9726 3178343 Maybridge4_002160 CSc1c(C#N)c(nn1C(=O)C(C)(C)C)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C05 compound treatment 2.1601453E8 3.89E7 0.49 1.9476278E8 2.28E7 0.39 0.6208 0.9938 3063778 Maybridge4_002161 CS/C(=N/C(=N)Nc1ccc(Cl)cc1)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C06 compound treatment 1.88909839E8 1.18E7 0.15 1.75002064E8 3020000.0 0.05 0.1412 0.901 3178344 Maybridge4_002162 Cc1c(csc1C(=O)Nc2ccc(F)cc2F)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C07 compound treatment 2.06217559E8 2.91E7 0.37 1.75546826E8 3570000.0 0.06 0.3013 0.8141 1368486 Maybridge4_002163 OC(=O)c1ccccc1SCC(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C08 compound treatment 2.04060466E8 2.69E7 0.34 1.79792952E8 7820000.0 0.13 0.3336 0.9177 3178345 Maybridge4_002164 CNC(=S)Nc1cscc1S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C09 compound treatment 1.8000208E8 2880000.0 0.04 1.74728017E8 2750000.0 0.05 0.0589 0.9915 3063810 Maybridge4_002165 Clc1cccc(NC(=S)NC(C#N)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C10 compound treatment 1.71522421E8 -5600000.0 -0.07 1.5046526E8 -2.15E7 -0.37 -0.31 -0.827 3178346 Maybridge4_002166 CN(C)/C=C/C(=O)c1cnc2cc(C)nn2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C11 compound treatment 1.75634768E8 -1480000.0 -0.02 1.60527418E8 -1.15E7 -0.2 -0.1518 -0.7708 1175106 Maybridge4_002167 Cc1c(nnc2cc(nn12)c3ccccc3)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C12 compound treatment 1.78678046E8 1560000.0 0.02 1.59131221E8 -1.28E7 -0.22 -0.1417 -0.6417 3178347 Maybridge4_002168 COC(=O)c1scc(c1n2cccc2)S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C13 compound treatment 1.79271591E8 2150000.0 0.03 1.55195177E8 -1.68E7 -0.29 -0.1841 -0.6379 1474680 Maybridge4_002169 NC1=C(C#N)C(C(=C(O1)C2CC2)C#N)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C14 compound treatment 1.8454059E8 7420000.0 0.09 1.75221505E8 3240000.0 0.06 0.1051 0.9695 1123050 Maybridge4_002170 CC(C)S(=O)(=O)c1cscc1NC(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C15 compound treatment 1.91486962E8 1.44E7 0.18 1.74214878E8 2240000.0 0.04 0.1545 0.8386 1443948 Maybridge4_002171 O=c1c2CSCc2[nH]c3cc(nn13)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C16 compound treatment 1.69774174E8 -7350000.0 -0.09 1.50292532E8 -2.17E7 -0.37 -0.3276 -0.8566 3063812 Maybridge4_002172 CC(C)S(=O)(=O)c1csc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C17 compound treatment 1.4038118E8 -3.67E7 -0.46 1.58903002E8 -1.31E7 -0.22 -0.4841 -0.945 1153510 Maybridge4_002173 COc1c(Cl)scc1NC(=O)N2CC(C)OC(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C18 compound treatment 1.77610599E8 491000.0 0.01 1.54617935E8 -1.74E7 -0.3 -0.2058 -0.6923 3063813 Maybridge4_002174 CS(=O)(=O)c1scc(c1C#N)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C19 compound treatment 1.72944331E8 -4180000.0 -0.05 1.50069707E8 -2.19E7 -0.38 -0.3022 -0.7981 3178348 Maybridge4_002175 CC(C)(C)c1ccc(cc1)c2n[nH]c(c2C#N)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C20 compound treatment 1.56890995E8 -2.02E7 -0.25 1.39229759E8 -3.27E7 -0.56 -0.5758 -0.9358 3178349 Maybridge4_002176 Cn1nc(cc1C(F)(F)F)c2ccc(s2)C(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C21 compound treatment 1.6248993E8 -1.46E7 -0.18 1.55053631E8 -1.69E7 -0.29 -0.3346 -0.9757 3063814 Maybridge4_002177 COC(=O)c1sc(SC)c(C#N)c1c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C22 compound treatment 1.68766978E8 -8350000.0 -0.1 1.51414403E8 -2.06E7 -0.35 -0.323 -0.8795 3178350 Maybridge4_002178 CCN(CCS(=O)(=O)c1ccc(C)cc1)C(=O)c2ccc(s2)c3cc(nn3C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C23 mock treatment 1.79067244E8 1950000.0 0.02 1.61026974E8 -1.1E7 -0.19 -0.1153 -0.6098 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 C24 mock treatment 1.78829419E8 1710000.0 0.02 1.64544296E8 -7430000.0 -0.13 -0.0748 -0.5797 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D01 compound treatment 1.77503354E8 384000.0 0.0 1.66841437E8 -5140000.0 -0.09 -0.0588 -0.6674 3063815 Maybridge4_002179 Nc1nc(ncc1S(=O)(=O)Cc2ccco2)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D02 compound treatment 1.97875591E8 2.08E7 0.26 1.67243587E8 -4730000.0 -0.08 0.1268 0.465 3063818 Maybridge4_002180 CC(C)(C)S(=O)(=O)c1cnc(nc1N)c2cnccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D03 compound treatment 2.03920466E8 2.68E7 0.34 1.72879424E8 902000.0 0.02 0.2486 0.7388 3178351 Maybridge4_002181 Cc1csc2sc(COC(=O)Nc3ccccc3)c(C)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D04 compound treatment 1.96852383E8 1.97E7 0.25 1.19828526E8 -5.21E7 -0.89 -0.4562 -0.4924 3178352 Maybridge4_002182 CSc1sc(C(=O)NN)c2CCCC3(SCCS3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D05 compound treatment 1.78489673E8 1370000.0 0.02 1.65762655E8 -6220000.0 -0.11 -0.0631 -0.5853 3063851 Maybridge4_002183 CCOC(=O)c1sc(c2/C(=N\O)/CC(C)(C)Cc12)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D06 compound treatment 1.7873608E8 1620000.0 0.02 1.57590499E8 -1.44E7 -0.25 -0.1598 -0.6467 3178353 Maybridge4_002184 Cc1ccc(cc1)S(=O)(=O)CCSc2sc(C#N)c3CC(C)(C)CC(=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D07 compound treatment 1.93180474E8 1.61E7 0.2 1.75697162E8 3720000.0 0.06 0.1875 0.8873 1145089 Maybridge4_002185 CSc1sc(C(=O)O)c-2c1S(=O)(=O)N(C)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D08 compound treatment 2.07936347E8 3.08E7 0.39 1.9260272E8 2.06E7 0.35 0.523 0.999 3178354 Maybridge4_002186 FC(F)(F)c1cccc(c1)C(=O)C(=C2SCCCCS2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D09 compound treatment 1.80722304E8 3600000.0 0.05 1.7134751E8 -630000.0 -0.01 0.0243 0.5236 3063853 Maybridge4_002187 Cn1nc(cc1C(F)(F)F)c2ccc(s2)S(=O)(=O)NCc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D10 compound treatment 2.00072155E8 2.3E7 0.29 1.72524507E8 547000.0 0.01 0.2102 0.7297 3178355 Maybridge4_002188 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)S(=O)(=O)c4cccc(c4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D11 compound treatment 1.72700563E8 -4420000.0 -0.06 1.54319666E8 -1.77E7 -0.3 -0.2529 -0.8231 3063854 Maybridge4_002189 CSc1sc(cc1S(=O)(=O)C(C)C)C(=O)Sc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D12 compound treatment 2.17016318E8 3.99E7 0.5 1.64973916E8 -7000000.0 -0.12 0.2691 0.5229 3178356 Maybridge4_002190 CC1(C)CCc2cc(ccc2O1)c3ccnc(S)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D13 compound treatment 2.00303754E8 2.32E7 0.29 1.68524431E8 -3450000.0 -0.06 0.1639 0.5521 3063856 Maybridge4_002191 Cc1c(Br)sc2sc(c(C)c12)c3nn(C)cc3Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D14 compound treatment 2.16154203E8 3.9E7 0.49 1.78625143E8 6650000.0 0.11 0.4267 0.8488 3178357 Maybridge4_002192 CSc1sc(Cl)c2CC(C)(C)C/C(=N/O)/c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D15 compound treatment 1.93877751E8 1.68E7 0.21 1.72325951E8 348000.0 0.01 0.1529 0.7269 3178358 Maybridge4_002193 CC(C)NC(=O)CSc1nccc(n1)c2sc3sc(Br)c(C)c3c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D16 compound treatment 1.7460635E8 -2510000.0 -0.03 1.54259792E8 -1.77E7 -0.3 -0.2368 -0.7764 3063857 Maybridge4_002194 Sc1nccc(n1)c2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D17 compound treatment 1.95558464E8 1.84E7 0.23 1.82988348E8 1.1E7 0.19 0.2968 0.9948 3063858 Maybridge4_002195 COc1ccc(CSc2nnc(CSc3cccs3)n2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D18 compound treatment 2.07076488E8 3.0E7 0.38 1.82521032E8 1.05E7 0.18 0.3933 0.9435 3178359 Maybridge4_002196 CS(=O)(=NS(=O)(=O)c1cccc2nsnc12)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D19 compound treatment 1.96287905E8 1.92E7 0.24 1.60485229E8 -1.15E7 -0.2 0.0309 0.0995 3178360 Maybridge4_002197 Cc1cc2ncc(c(C)n2n1)c3ccnc(SCCS(=O)(=O)c4ccccc4)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D20 compound treatment 1.78833702E8 1710000.0 0.02 1.50222263E8 -2.18E7 -0.37 -0.2481 -0.6652 3063859 Maybridge4_002198 CC(C)C1Oc2c(cccc2N(CC(=O)O)C1=S)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D21 compound treatment 1.92653909E8 1.55E7 0.19 1.84296761E8 1.23E7 0.21 0.2869 0.9992 3178361 Maybridge4_002199 CSc1nc(nc(c1C#N)c2ccc(OC(F)(F)F)cc2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D22 compound treatment 1.98051924E8 2.09E7 0.26 1.67310604E8 -4670000.0 -0.08 0.1292 0.4707 1139728 Maybridge4_002200 CCOC(=O)CC1Sc2ccccc2N=C1SCCS(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D23 mock treatment 1.78364732E8 1250000.0 0.02 1.66617163E8 -5360000.0 -0.09 -0.0538 -0.5784 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 D24 mock treatment 1.83496791E8 6380000.0 0.08 1.62479397E8 -9500000.0 -0.16 -0.0584 -0.3223 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E01 compound treatment 1.57282577E8 -1.98E7 -0.25 1.6010735E8 -1.19E7 -0.2 -0.3196 -0.9949 1149948 Maybridge4_002201 Clc1ccc(cc1)N2CCN(CC2)C3=Cc4ccccc4C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E02 compound treatment 1.1241039E8 -6.47E7 -0.81 1.43926577E8 -2.81E7 -0.48 -0.9135 -0.9686 3178362 Maybridge4_002202 COC(=O)c1ccccc1S(=O)(=O)/C(=C/Nc2nc(SC)nc(n2)C3CC3)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E03 compound treatment 1.8067E8 3550000.0 0.04 1.7142596E8 -552000.0 -0.01 0.0248 0.545 3063320 Maybridge4_002203 CSc1nc(N)n(n1)c2cc(Cl)cc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E04 compound treatment 1.70477528E8 -6640000.0 -0.08 1.79049747E8 7070000.0 0.12 0.0267 0.1816 3178363 Maybridge4_002204 CSc1n[nH]c(NC(=O)c2ccccc2Cl)c1S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E05 compound treatment 1.79248989E8 2130000.0 0.03 1.90513319E8 1.85E7 0.32 0.2432 0.7639 1032087 Maybridge4_002205 Oc1ccnc(SCc2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E06 compound treatment 1.85428352E8 8310000.0 0.1 1.88401534E8 1.64E7 0.28 0.2725 0.9088 3178364 Maybridge4_002206 CN1c2ccccc2C(=O)/C(=C\Nc3ncccn3)/S1(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E07 compound treatment 1.8675983E8 9640000.0 0.12 1.70802642E8 -1180000.0 -0.02 0.0713 0.5815 3063324 Maybridge4_002207 CCN(CCC#N)C(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E08 compound treatment 1.85148869E8 8030000.0 0.1 1.87640222E8 1.57E7 0.27 0.2608 0.9106 1520456 Maybridge4_002208 CCOC(=O)NS(=O)(=O)c1ccccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E09 compound treatment 1.99468308E8 2.23E7 0.28 1.91112353E8 1.91E7 0.33 0.4298 0.997 1248613 Maybridge4_002209 O=c1cc([nH]c2cc(nn12)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E10 compound treatment 1.74889605E8 -2230000.0 -0.03 1.56983422E8 -1.5E7 -0.26 -0.2013 -0.7796 3178365 Maybridge4_002210 Cc1cccc(c1)c2n[nH]c(c2C#N)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E11 compound treatment 1.78406211E8 1290000.0 0.02 1.75666941E8 3690000.0 0.06 0.0561 0.8602 1374930 Maybridge4_002211 COc1cccc(c1)c2c(nnc3cc(nn23)c4ccccc4)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E12 compound treatment 1.85917243E8 8800000.0 0.11 1.87578892E8 1.56E7 0.27 0.2669 0.9236 1289071 Maybridge4_002212 Clc1ccc(cc1)S(=O)(=O)CCSc2ccccc2NC(=O)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E13 compound treatment 1.37143899E8 -4.0E7 -0.5 1.2382471E8 -4.82E7 -0.82 -0.9375 -0.9716 1391332 Maybridge4_002213 COc1ccc(cc1)C2C(=C(N)OC(=C2C#N)C3CC3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E14 compound treatment 1.72022835E8 -5100000.0 -0.06 1.62783454E8 -9190000.0 -0.16 -0.1565 -0.9212 3063326 Maybridge4_002214 Cc1nccc(n1)c2cccc(NS(=O)(=O)c3ccccc3C(F)(F)F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E15 compound treatment 1.36978617E8 -4.01E7 -0.5 1.87832295E8 1.59E7 0.27 -0.1642 -0.287 3178456 Maybridge4_002215 Cn1nc(cc1N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E16 compound treatment 1.68249781E8 -8870000.0 -0.11 1.75038653E8 3060000.0 0.05 -0.0416 -0.3385 1540260 Maybridge4_002216 CC(C)S(=O)(=O)c1csc(NC(=O)N2CCCCC2)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E17 compound treatment 1.35925681E8 -4.12E7 -0.52 1.64944616E8 -7030000.0 -0.12 -0.4505 -0.8491 1698879 Maybridge4_002217 Nc1nc(ncc1S(=O)(=O)c2ccc(Cl)cc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E18 compound treatment 1.48790454E8 -2.83E7 -0.36 1.51295055E8 -2.07E7 -0.35 -0.5016 -1.0 1598720 Maybridge4_002218 Clc1ccc(cc1)c2csc(S(=O)C3CCCCC3)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E19 compound treatment 1.58773811E8 -1.83E7 -0.23 1.43224468E8 -2.88E7 -0.49 -0.5108 -0.94 1438402 Maybridge4_002219 O=C(c1ccccc1)c2cnc3ccccn3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E20 compound treatment 1.83563191E8 6440000.0 0.08 1.75723011E8 3750000.0 0.06 0.1025 0.9934 3178457 Maybridge4_002220 CN(C)c1scc(c1C#N)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E21 compound treatment 1.64523573E8 -1.26E7 -0.16 1.72839411E8 862000.0 0.01 -0.1013 -0.6383 3178458 Maybridge4_002221 Cc1ccc(cc1)S(=O)(=O)/C(=C/Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E22 compound treatment 1.66847739E8 -1.03E7 -0.13 1.58825943E8 -1.32E7 -0.23 -0.2503 -0.9649 1367919 Maybridge4_002222 O=S(=O)(Cc1ccco1)Cc2nc(cs2)c3ccc(cc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E23 mock treatment 1.68072351E8 -9050000.0 -0.11 1.73529267E8 1550000.0 0.03 -0.0615 -0.5274 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 E24 mock treatment 1.62840021E8 -1.43E7 -0.18 1.51097492E8 -2.09E7 -0.36 -0.3794 -0.949 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F01 compound treatment 1.51786076E8 -2.53E7 -0.32 1.63337259E8 -8640000.0 -0.15 -0.3293 -0.9394 3063357 Maybridge4_002223 CNC(=O)c1cc(C#N)c(SC)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F02 compound treatment 1.84894357E8 7770000.0 0.1 1.68989845E8 -2990000.0 -0.05 0.0328 0.2978 3178459 Maybridge4_002224 CSc1scc2CCc3cnc(SCC(=O)c4ccc(Cl)cc4)nc3-c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F03 compound treatment 1.90889991E8 1.38E7 0.17 1.71089519E8 -888000.0 -0.02 0.1114 0.6424 3063358 Maybridge4_002225 Cc1csc2sc(C(=O)Oc3ccc(Cl)cc3)c(C)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F04 compound treatment 1.9718545E8 2.01E7 0.25 1.23355931E8 -4.86E7 -0.83 -0.4105 -0.4721 3178460 Maybridge4_002226 Nc1nc(ncc1S(=O)(=O)c2ccc(cn2)C(F)(F)F)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F05 compound treatment 1.65237113E8 -1.19E7 -0.15 1.67242639E8 -4740000.0 -0.08 -0.1627 -0.959 3063359 Maybridge4_002227 CSc1sc(cc1c2nc(C)cs2)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F06 compound treatment 1.73120549E8 -4000000.0 -0.05 1.61980137E8 -1.0E7 -0.17 -0.1565 -0.8775 3178461 Maybridge4_002228 CC(C)S(=O)(=O)c1cscc1NC(=O)c2ccc(s2)c3cc(nn3C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F07 compound treatment 1.68240166E8 -8880000.0 -0.11 1.7338313E8 1410000.0 0.02 -0.0618 -0.5419 1693988 Maybridge4_002229 CS(=O)(=O)c1sc(C(=O)Nc2ccccc2Cl)c3CCC=Cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F08 compound treatment 1.09622979E8 -6.75E7 -0.85 1.10793808E8 -6.12E7 -1.05 -1.3393 -0.9944 3178462 Maybridge4_002230 CSc1sc(c2ccon2)c(c1C#N)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F09 compound treatment 1.66922321E8 -1.02E7 -0.13 1.58938379E8 -1.3E7 -0.22 -0.2483 -0.9651 3178463 Maybridge4_002231 CC1(C)CC(=O)C=C(SCC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F10 compound treatment 1.74433378E8 -2690000.0 -0.03 1.19989327E8 -5.2E7 -0.89 -0.6531 -0.7334 3063360 Maybridge4_002232 FC(F)(F)c1ccc(nc1)S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F11 compound treatment 1.68931111E8 -8190000.0 -0.1 1.57683641E8 -1.43E7 -0.24 -0.2457 -0.9257 3178464 Maybridge4_002233 CS(=O)(=NS(=O)(=O)c1ccc(s1)c2ccccn2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F12 compound treatment 1.53114834E8 -2.4E7 -0.3 1.55979377E8 -1.6E7 -0.27 -0.4066 -0.9989 3063362 Maybridge4_002234 C/S(=N\C(=O)Nc1ccc(Cl)cc1)/c2sc(Cl)c3CCCC(=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F13 compound treatment 1.3100483E8 -4.61E7 -0.58 1.83002894E8 1.1E7 0.19 -0.2756 -0.4529 3178465 Maybridge4_002235 CS(=O)(=NC(=S)NC(=O)Oc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F14 compound treatment 1.83102188E8 5980000.0 0.08 1.7803497E8 6060000.0 0.1 0.1264 0.9874 3063392 Maybridge4_002236 FC(F)(F)c1cnc(N2CCS(=NC(=O)c3ccccc3)CC2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F15 compound treatment 1.26998701E8 -5.01E7 -0.63 1.61760181E8 -1.02E7 -0.17 -0.5683 -0.8707 3178466 Maybridge4_002237 Cc1c(Br)sc2sc(c(C)c12)c3ccnc(SCC(=O)NCC=C)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F16 compound treatment 1.93836722E8 1.67E7 0.21 1.89441629E8 1.75E7 0.3 0.3597 0.985 1201268 Maybridge4_002238 C(Sc1nccc(n1)c2ccc3OCCc3c2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F17 compound treatment 1.56782439E8 -2.03E7 -0.26 1.09363095E8 -6.26E7 -1.07 -0.9383 -0.8516 1378146 Maybridge4_002239 CS(=O)(=O)c1sc(NC(=O)Nc2ccc(Cl)cc2)c3CCC=Cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F18 compound treatment 1.17181878E8 -5.99E7 -0.75 1.2441306E8 -4.76E7 -0.81 -1.1074 -0.9992 1406686 Maybridge4_002240 Cc1nn(Cc2cccc(c2)C(=O)NC(=O)Nc3ccc(Cl)cc3)c(C)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F19 compound treatment 1.76869534E8 -250000.0 0.0 1.78733847E8 6760000.0 0.12 0.0796 0.6877 1721379 Maybridge4_002241 O=S(=O)(N1CCCCC1)c2ccc(s2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F20 compound treatment 1.89168041E8 1.2E7 0.15 1.57009643E8 -1.5E7 -0.26 -0.0743 -0.2498 3063394 Maybridge4_002242 CN(C)/C=C\1/C(=O)c2sccc2N(C)S1(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F21 compound treatment 1.59102893E8 -1.8E7 -0.23 1.67633412E8 -4340000.0 -0.07 -0.2124 -0.8927 3178467 Maybridge4_002243 CSc1sc(c(C)c1c2ccnc(S)n2)c3nc(C)cs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F22 compound treatment 1.78309889E8 1190000.0 0.01 1.10001834E8 -6.2E7 -1.06 -0.7396 -0.6971 1422989 Maybridge4_002244 Clc1ccc(OC(=O)c2csc(n2)C3COc4ccccc4O3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F23 mock treatment 1.92530559E8 1.54E7 0.19 1.68799641E8 -3180000.0 -0.05 0.0982 0.4891 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 F24 mock treatment 1.69286287E8 -7830000.0 -0.1 1.58114128E8 -1.39E7 -0.24 -0.2373 -0.9238 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G01 compound treatment 1.41034471E8 -3.61E7 -0.45 1.62202084E8 -9780000.0 -0.17 -0.4384 -0.9084 1651892 Maybridge4_002245 CCCCC1(Cc2ccccc2)C(=O)Nc3ccccc3C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G02 compound treatment 9.8691747E7 -7.84E7 -0.98 1.25731952E8 -4.62E7 -0.79 -1.2555 -0.9942 3178468 Maybridge4_002246 CSc1nc(N/C=C(\C#N)/S(=O)(=O)c2ccccc2Cl)nc(n1)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G03 compound treatment 1.20213541E8 -5.69E7 -0.71 1.58257611E8 -1.37E7 -0.23 -0.6708 -0.8927 3063398 Maybridge4_002247 CC(=N)NC(=S)Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G04 compound treatment 1.53770013E8 -2.33E7 -0.29 1.68873714E8 -3100000.0 -0.05 -0.2447 -0.822 3178469 Maybridge4_002248 CSc1n[nH]c(NC(=O)Nc2ccccc2)c1S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G05 compound treatment 1.4262827E8 -3.45E7 -0.43 1.62558634E8 -9420000.0 -0.16 -0.42 -0.9095 3063400 Maybridge4_002249 CN(C)C(=O)Oc1ccnc(SCc2c(F)cccc2Cl)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G06 compound treatment 1.63961099E8 -1.32E7 -0.17 1.80713054E8 8740000.0 0.15 -0.011 -0.0493 3178470 Maybridge4_002250 COc1ccc(cc1)c2n[nH]c(SC)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G07 compound treatment 1.70720151E8 -6400000.0 -0.08 1.74542068E8 2560000.0 0.04 -0.0257 -0.2812 3063401 Maybridge4_002251 Cc1ccc(COc2ccc(I)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G08 compound treatment 1.5743094E8 -1.97E7 -0.25 1.84800321E8 1.28E7 0.22 -0.0194 -0.0588 3178471 Maybridge4_002252 CSc1sc(C(=O)Nc2cccc(Cl)c2)c(c1C#N)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G09 compound treatment 1.59766323E8 -1.74E7 -0.22 1.75514609E8 3540000.0 0.06 -0.1111 -0.4918 1687124 Maybridge4_002253 CCN(CCS(=O)(=O)c1ccccc1)S(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G10 compound treatment 1.58451612E8 -1.87E7 -0.23 1.74369195E8 2390000.0 0.04 -0.1366 -0.5748 3178472 Maybridge4_002254 COC(=O)c1scc(c1N)S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G11 compound treatment 1.7568184E8 -1440000.0 -0.02 1.7134917E8 -629000.0 -0.01 -0.0204 -0.9695 1226475 Maybridge4_002255 NC(=O)c1nnc2cc(nn2c1N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G12 compound treatment 1.56720323E8 -2.04E7 -0.26 1.76263568E8 4290000.0 0.07 -0.1291 -0.4849 1452741 Maybridge4_002256 Clc1ccc(cc1)S(=O)(=O)CCSc2ccccc2NC(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G13 compound treatment 1.56390523E8 -2.07E7 -0.26 1.55829628E8 -1.61E7 -0.28 -0.3793 -0.9995 3063431 Maybridge4_002257 Fc1cccc(Cl)c1CN/C(=C(\N=C\c2cccs2)/C#N)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G14 compound treatment 1.51786922E8 -2.53E7 -0.32 1.68003073E8 -3970000.0 -0.07 -0.2728 -0.8395 3178473 Maybridge4_002258 Clc1cccc(Cl)c1CSc2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G15 compound treatment 1.61773748E8 -1.53E7 -0.19 1.76366406E8 4390000.0 0.08 -0.083 -0.4017 3178474 Maybridge4_002259 COc1ccc(/C=C(\C#N)/S(=O)(=O)c2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G16 compound treatment 1.86431417E8 9310000.0 0.12 1.73917813E8 1940000.0 0.03 0.1061 0.8735 1133071 Maybridge4_002260 CNC(=O)Nc1ccccc1NC2=C(CSC2)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G17 compound treatment 1.06797008E8 -7.03E7 -0.88 1.63014189E8 -8960000.0 -0.15 -0.7323 -0.8178 3178475 Maybridge4_002261 CC1CN(CC(C)O1)/C=C(\C#N)/S(=O)(=O)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G18 compound treatment 1.14867474E8 -6.23E7 -0.78 1.65633099E8 -6340000.0 -0.11 -0.629 -0.7978 3063432 Maybridge4_002262 CS(=O)(=NS(=O)(=O)c1ccccc1C(F)(F)F)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G19 compound treatment 1.32365848E8 -4.48E7 -0.56 1.60486391E8 -1.15E7 -0.2 -0.5361 -0.9011 1259331 Maybridge4_002263 COCc1cc(O)nc2n(C)nc(c3cccs3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G20 compound treatment 1.721481E8 -4970000.0 -0.06 1.74175181E8 2200000.0 0.04 -0.0175 -0.2403 3063433 Maybridge4_002264 CS/C(=C(/C#N)\S(=O)(=O)C(C)C)/N1CCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G21 compound treatment 1.12610779E8 -6.45E7 -0.81 1.66111345E8 -5870000.0 -0.1 -0.6432 -0.7888 3178476 Maybridge4_002265 CSc1c(C#N)c(nn1CC(=O)NN)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G22 compound treatment 1.67005897E8 -1.01E7 -0.13 1.67145064E8 -4830000.0 -0.08 -0.1482 -0.9785 3063434 Maybridge4_002266 Cc1onc(c1C(=O)N=S(=O)(C)C)c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G23 mock treatment 1.66594527E8 -1.05E7 -0.13 1.60070402E8 -1.19E7 -0.2 -0.2375 -0.9779 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 G24 mock treatment 1.65245308E8 -1.19E7 -0.15 1.65469946E8 -6510000.0 -0.11 -0.1841 -0.9898 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H01 compound treatment 1.67317626E8 -9800000.0 -0.12 1.57966502E8 -1.4E7 -0.24 -0.2565 -0.9518 3178477 Maybridge4_002267 CCOC(=O)c1sc(SCc2ccccc2)c(c1n3cccc3)S(=O)(=O)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H02 compound treatment 1.67415889E8 -9700000.0 -0.12 1.59851005E8 -1.21E7 -0.21 -0.2329 -0.9677 1259984 Maybridge4_002268 CSc1scc2CCc3cnc(SCC(=O)C(C)(C)C)nc3-c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H03 compound treatment 1.79865225E8 2750000.0 0.03 1.80899824E8 8920000.0 0.15 0.1323 0.8453 3063436 Maybridge4_002269 CSc1sc(cc1S(=O)(=O)C(C)C)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H04 compound treatment 1.72576126E8 -4540000.0 -0.06 1.59246107E8 -1.27E7 -0.22 -0.1944 -0.863 3178558 Maybridge4_002270 COC(=O)c1sc(SCCOC(=O)c2ccccc2Cl)c3C(=O)CC(C)(C)Cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H05 compound treatment 1.20813457E8 -5.63E7 -0.71 1.73631274E8 1650000.0 0.03 -0.4794 -0.6782 3063438 Maybridge4_002271 CSc1sc(C#N)c(C)c1c2ccn(n2)C(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H06 compound treatment 1.44198034E8 -3.29E7 -0.41 1.30800899E8 -4.12E7 -0.7 -0.7904 -0.9676 3178559 Maybridge4_002272 CSc1sc(C(=O)/C=C/N(C)C)c(c1C#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H07 compound treatment 1.01187636E8 -7.59E7 -0.95 9.8579132E7 -7.34E7 -1.26 -1.562 -0.9907 1222048 Maybridge4_002273 CS(=O)c1sc(C(=O)OCc2ccccc2)c3CC(C)(C)CC(=O)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H08 compound treatment 1.53133702E8 -2.4E7 -0.3 1.45227984E8 -2.67E7 -0.46 -0.5365 -0.9793 3178560 Maybridge4_002274 CSc1sc(c2cc[nH]n2)c(c1C#N)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H09 compound treatment 1.54829265E8 -2.23E7 -0.28 1.56538641E8 -1.54E7 -0.26 -0.3846 -0.9996 3178561 Maybridge4_002275 CC1(C)CC(=O)C=C(SCc2c(Cl)cccc2Cl)S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H10 compound treatment 8.9578654E7 -8.75E7 -1.1 1.5868276E8 -1.33E7 -0.23 -0.9374 -0.8359 1307156 Maybridge4_002276 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H11 compound treatment 1.30372883E8 -4.67E7 -0.59 1.84767498E8 1.28E7 0.22 -0.2598 -0.4151 3063440 Maybridge4_002277 CSc1nnc(c2ccc(s2)S(=O)(=O)n3nc(C)cc3C)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H12 compound treatment 1.70208747E8 -6910000.0 -0.09 1.66989754E8 -4990000.0 -0.09 -0.1217 -1.0 3178562 Maybridge4_002278 CCSc1nccc(n1)c2ccc3OC(C)(C)CCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H13 compound treatment 1.78680425E8 1560000.0 0.02 1.76807922E8 4830000.0 0.08 0.0723 0.851 3063442 Maybridge4_002279 Cc1csc2sc(c(C)c12)c3ccnc(SCc4ccccc4)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H14 compound treatment 1.51463851E8 -2.57E7 -0.32 1.56190376E8 -1.58E7 -0.27 -0.4187 -0.9962 3178563 Maybridge4_002280 CCOC(=O)c1sc(/S(=N/C(=O)Nc2ccccc2Cl)/C)c3C=CCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H15 compound treatment 1.82063075E8 4940000.0 0.06 1.69137E8 -2840000.0 -0.05 0.0095 0.1201 1505800 Maybridge4_002281 COC(=O)C(CC(C)C)NS(=O)(=O)c1ccc(s1)c2nnc(SC)n2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H16 compound treatment 1.85694437E8 8570000.0 0.11 1.78632153E8 6650000.0 0.11 0.1566 0.9996 3178564 Maybridge4_002282 FC(F)(F)c1ccc(nc1)S(=O)(=O)CCSc2ncccc2C(=O)NCc3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H17 compound treatment 1.14002705E8 -6.31E7 -0.79 1.14655792E8 -5.73E7 -0.98 -1.2537 -0.9943 3178565 Maybridge4_002283 Clc1ccc(cc1)C2CC(=O)C=C(SCC(=O)c3ccccc3)S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H18 compound treatment 1.38797877E8 -3.83E7 -0.48 1.29680798E8 -4.23E7 -0.72 -0.8519 -0.9802 3063443 Maybridge4_002284 C/C(=N\O)/c1ccc2OCCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H19 compound treatment 1.77409529E8 290000.0 0.0 1.6877397E8 -3200000.0 -0.05 -0.0362 -0.6588 3063445 Maybridge4_002285 CC1(C)CC(=O)c2c(SCC(=O)NN)sc(C#N)c2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H20 compound treatment 1.91405415E8 1.43E7 0.18 1.80109068E8 8130000.0 0.14 0.2251 0.9922 1254429 Maybridge4_002286 Cc1nn(C)c2ncc(C(=O)N)c(Oc3cccnc3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H21 compound treatment 1.80024351E8 2900000.0 0.04 1.66404176E8 -5570000.0 -0.1 -0.0417 -0.4083 3063446 Maybridge4_002287 CCOC(=O)c1sc(SC)c2c1CCCC32SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H22 compound treatment 1.29728885E8 -4.74E7 -0.59 1.77301012E8 5320000.0 0.09 -0.3559 -0.5918 1921420 Maybridge4_002288 OC(=O)/C=C/1\OC(=O)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H23 mock treatment 1.55538304E8 -2.16E7 -0.27 1.64645334E8 -7330000.0 -0.13 -0.2802 -0.9389 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 H24 mock treatment 1.68061083E8 -9060000.0 -0.11 1.60341122E8 -1.16E7 -0.2 -0.2212 -0.9646 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I01 compound treatment 1.50887468E8 -2.62E7 -0.33 1.7160342E8 -374000.0 -0.01 -0.2372 -0.7207 3178566 Maybridge4_002289 Cc1ccc(cc1)C(=O)OC[C@H]2O[C@@H](C[C@@H]2OC(=O)c3ccc(C)cc3)c4nnc5ncccn45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I02 compound treatment 1.59794941E8 -1.73E7 -0.22 1.75911505E8 3930000.0 0.07 -0.1061 -0.4662 3178567 Maybridge4_002290 FC(F)(F)c1cc(N/C=C(\C#N)/S(=O)(=O)Cc2ccc(Cl)cc2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I03 compound treatment 1.65824294E8 -1.13E7 -0.14 1.75460669E8 3480000.0 0.06 -0.058 -0.3775 3063447 Maybridge4_002291 CCOC(=O)c1c(C)noc1c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I04 compound treatment 1.4734823E8 -2.98E7 -0.37 1.59407657E8 -1.26E7 -0.22 -0.4162 -0.9657 3064096 Maybridge4_002292 CSc1sc(NC(=O)N2CCOCC2)c(c1C#N)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I05 compound treatment 2.06187384E8 2.91E7 0.36 1.95686784E8 2.37E7 0.41 0.5448 0.9986 3064097 Maybridge4_002293 CCOC(=O)/C=C/1\NC(=O)CS1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I06 compound treatment 2.08057057E8 3.09E7 0.39 2.01513666E8 2.95E7 0.51 0.6319 0.9915 3064098 Maybridge4_002294 CSc1[nH]nc(c1C#N)c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I07 compound treatment 2.00232948E8 2.31E7 0.29 2.03079024E8 3.11E7 0.53 0.5815 0.9592 3064099 Maybridge4_002295 Fc1ccc(NC(=S)N(CCC#N)CC2CCCO2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I08 compound treatment 2.06975407E8 2.99E7 0.37 1.95754031E8 2.38E7 0.41 0.5526 0.9991 3064100 Maybridge4_002296 CSc1sc(C(=O)O)c(C)c1S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I09 compound treatment 2.16695055E8 3.96E7 0.5 2.01835909E8 2.99E7 0.51 0.7125 0.9999 1242964 Maybridge4_002297 Cc1nn(c(NC(=O)c2ccccc2)c1C#N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I10 compound treatment 2.15029949E8 3.79E7 0.48 2.15732986E8 4.38E7 0.75 0.8659 0.976 3064101 Maybridge4_002298 CC(C)(C)S(=O)(=O)/C(=C/Nc1ccccn1)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I11 compound treatment 2.11669892E8 3.46E7 0.43 2.00851213E8 2.89E7 0.49 0.656 0.9979 1003716 Maybridge4_002299 Cc1ccc(cc1)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I12 compound treatment 2.35457084E8 5.83E7 0.73 2.32604808E8 6.06E7 1.04 1.2513 0.9854 3064102 Maybridge4_002300 COC(=O)c1scc(c1/N=C/N(C)C)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I13 compound treatment 2.08287207E8 3.12E7 0.39 1.90787489E8 1.88E7 0.32 0.5041 0.9953 3178568 Maybridge4_002301 COc1cccc(c1)C(=O)/C=c/2\[nH]c(=O)\c(=C/c3cccs3)\s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I14 compound treatment 2.25296665E8 4.82E7 0.6 2.37322132E8 6.53E7 1.12 1.2183 0.9582 1621333 Maybridge4_002302 Cc1nccc(n1)c2cccc(NC(=O)Nc3ccccc3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I15 compound treatment 2.14098507E8 3.7E7 0.46 2.18075938E8 4.61E7 0.79 0.886 0.9679 1156135 Maybridge4_002303 CC(C)(C)c1ccc(cc1)c2n[nH]c(NS(=O)(=O)c3ccccc3)c2Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I16 compound treatment 2.53014342E8 7.59E7 0.95 2.24463444E8 5.25E7 0.9 1.3085 0.9996 3064103 Maybridge4_002304 COC(=O)c1sc(SC)c(C#N)c1c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I17 compound treatment 2.57996165E8 8.09E7 1.01 2.40244379E8 6.83E7 1.17 1.5437 0.9975 1665125 Maybridge4_002305 O=C(Nc1ccccc1)Nc2ccc(cc2)C3SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I18 compound treatment 1.92115616E8 1.5E7 0.19 1.94561371E8 2.26E7 0.39 0.4064 0.9452 3064104 Maybridge4_002306 O=S(=O)(C(=C1SCCCS1)C#N)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I19 compound treatment 2.24509065E8 4.74E7 0.59 2.24527979E8 5.26E7 0.9 1.0564 0.9798 3178569 Maybridge4_002307 CSc1nc2cc(C)nn2c(c1C#N)c3ccc(cc3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I20 compound treatment 2.30377849E8 5.33E7 0.67 2.44024501E8 7.2E7 1.23 1.3445 0.9585 3178570 Maybridge4_002308 Cc1ccc(cc1)S(=O)(=NC(=O)NC(=O)c2c(Cl)cccc2Cl)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I21 compound treatment 1.61188974E8 -1.59E7 -0.2 1.76126487E8 4150000.0 0.07 -0.0911 -0.4295 3064105 Maybridge4_002309 CSc1nc(C)nc(N/C=C(\C#N)/S(=O)(=O)c2ccc(C)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I22 compound treatment 2.17202894E8 4.01E7 0.5 2.31334763E8 5.94E7 1.02 1.074 0.9474 1118314 Maybridge4_002310 NNC(=O)c1csc(CS(=O)(=O)Cc2ccco2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I23 mock treatment 2.04262448E8 2.71E7 0.34 2.16015679E8 4.4E7 0.75 0.7738 0.9355 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 I24 mock treatment 2.04302644E8 2.72E7 0.34 2.17006499E8 4.5E7 0.77 0.7862 0.9327 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J01 compound treatment 1.7980913E8 2690000.0 0.03 1.95033648E8 2.31E7 0.39 0.3029 0.7648 3064106 Maybridge4_002311 CSc1sc(c2n[nH]cc2Br)c3CC(C)(C)CC(=O)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J02 compound treatment 2.53130745E8 7.6E7 0.95 2.39001828E8 6.7E7 1.15 1.4855 0.9958 3178571 Maybridge4_002312 CSc1scc2CCc3cnc(SCC(=O)NCC=C)nc3-c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J03 compound treatment 2.07114787E8 3.0E7 0.38 2.23680609E8 5.17E7 0.89 0.8919 0.9274 3064107 Maybridge4_002313 CSc1sc(C#N)c2CC(CC(=O)c12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J04 compound treatment 1.97922154E8 2.08E7 0.26 2.19769116E8 4.78E7 0.82 0.763 0.8886 3178572 Maybridge4_002314 NC(=S)c1cnn2c(cc(nc12)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J05 compound treatment 1.95428942E8 1.83E7 0.23 2.15105651E8 4.31E7 0.74 0.6844 0.8852 3064108 Maybridge4_002315 COC(=O)c1sccc1N/C=C(\C#N)/S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J06 compound treatment 2.19752861E8 4.26E7 0.53 2.03694169E8 3.17E7 0.54 0.7621 1.0 3178573 Maybridge4_002316 CCOC(=O)c1sc(SC)c-2c1CCc3conc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J07 compound treatment 1.99352531E8 2.22E7 0.28 2.07287455E8 3.53E7 0.6 0.6246 0.9383 3178574 Maybridge4_002317 Cc1nn(Cc2nnc(o2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)c(C)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J08 compound treatment 2.1817005E7 -1.55E8 -1.95 2.26079602E8 5.41E7 0.93 -0.7227 -0.335 3064109 Maybridge4_002318 CCCS(=O)(=O)/C(=C/c1sccc1Oc2ccccc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J09 compound treatment 2.14002129E8 3.69E7 0.46 2.02421163E8 3.04E7 0.52 0.6957 0.9982 3178575 Maybridge4_002319 Cc1ccc(cc1)S(=O)(=O)CCSC2=CC(=O)CC(C)(C)S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J10 compound treatment 2.34727906E8 5.76E7 0.72 2.30671254E8 5.87E7 1.0 1.2214 0.9869 3064110 Maybridge4_002320 Clc1ccc(cc1)c2ccnc(SCCS(=O)(=O)c3ccc(Cl)cc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J11 compound treatment 2.24058643E8 4.69E7 0.59 2.16707163E8 4.47E7 0.77 0.9578 0.9916 3178576 Maybridge4_002321 CSc1sc(C(=O)Sc2ccccc2)c-3c1S(=O)(=O)N(C)c4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J12 compound treatment 2.05677172E8 2.86E7 0.36 1.99414956E8 2.74E7 0.47 0.5854 0.9911 1454764 Maybridge4_002322 CCOC(=O)C1=C(Nc2ccc(OC(=O)C)cc2)C(=O)N(C1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J13 compound treatment 2.27670578E8 5.06E7 0.63 2.13830221E8 4.19E7 0.72 0.955 0.9981 3178577 Maybridge4_002323 Cc1csc2sc(c(C)c12)c3ccnc(SCC(=O)c4ccccc4)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J14 compound treatment 1.89040749E8 1.19E7 0.15 2.01470753E8 2.95E7 0.5 0.4627 0.8788 3178578 Maybridge4_002324 CCOC(=O)c1sc(/S(=N/S(=O)(=O)c2cccc(Cl)c2)/C)c3C=CCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J15 compound treatment 2.36949673E8 5.98E7 0.75 2.29930417E8 5.8E7 0.99 1.2322 0.9905 3064111 Maybridge4_002325 COc1cccc(NC(=S)N=S(=O)(C)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J16 compound treatment 2.28773127E8 5.17E7 0.65 2.33788682E8 6.18E7 1.06 1.2064 0.9723 3178579 Maybridge4_002326 CCCCc1ccc(NC(=O)N=S2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J17 compound treatment 2.11271098E8 3.42E7 0.43 2.11847316E8 3.99E7 0.68 0.7855 0.9748 3064112 Maybridge4_002327 Cc1nn(Cc2nnc(SCc3c(Cl)cccc3Cl)o2)c(C)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J18 compound treatment 1.89509031E8 1.24E7 0.16 1.93633561E8 2.17E7 0.37 0.372 0.9255 3178580 Maybridge4_002328 C/S(=N/C(=O)Nc1ccc(Cl)cc1)/c2ccc(OC(=O)c3ccc(Cl)cc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J19 compound treatment 1.86521942E8 9400000.0 0.12 2.04440432E8 3.25E7 0.56 0.4763 0.8385 3064113 Maybridge4_002329 CS(=O)(=NS(=O)(=O)c1cc(cs1)S(=O)(=O)c2ccccc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J20 compound treatment 2.06421549E8 2.93E7 0.37 2.26928202E8 5.5E7 0.94 0.925 0.916 1183286 Maybridge4_002330 CN1c2ccsc2-c3nc(SCc4ccc(Cl)cc4)ncc3S1(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J21 compound treatment 2.17577867E8 4.05E7 0.51 2.21190847E8 4.92E7 0.84 0.9546 0.9706 3064114 Maybridge4_002331 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)CCSc2ccc(cn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J22 compound treatment 2.10089541E8 3.3E7 0.41 2.07235905E8 3.53E7 0.6 0.7192 0.983 3178581 Maybridge4_002332 O=C(CCN1CCC(=N1)c2cccs2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J23 mock treatment 1.8936177E8 1.22E7 0.15 2.07891627E8 3.59E7 0.61 0.5433 0.8574 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 J24 mock treatment 1.93488326E8 1.64E7 0.21 1.98866571E8 2.69E7 0.46 0.4707 0.9338 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K01 compound treatment 1.22565687E8 -5.46E7 -0.68 1.37805932E8 -3.42E7 -0.58 -0.8975 -0.9969 3064115 Maybridge4_002333 C/C(=C\C#N)/Nc1c(C)n(C)n(c2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K02 compound treatment 1.26625817E8 -5.05E7 -0.63 1.30700152E8 -4.13E7 -0.71 -0.9475 -0.9985 3178657 Maybridge4_002334 CSc1sc(C(=O)O)c(c1C#N)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K03 compound treatment 1.62773883E8 -1.43E7 -0.18 1.60158014E8 -1.18E7 -0.2 -0.2703 -0.9983 1629094 Maybridge4_002335 NC(=S)NN1C2CSC1CS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K04 compound treatment 1.48478369E8 -2.86E7 -0.36 1.57123863E8 -1.49E7 -0.25 -0.4339 -0.9857 3178658 Maybridge4_002336 CSc1c(C#N)c(nn1C(=O)c2cccs2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K05 compound treatment 1.51866473E8 -2.53E7 -0.32 1.59870264E8 -1.21E7 -0.21 -0.3706 -0.9788 3178659 Maybridge4_002337 FC(F)(F)c1cccc(c1)S(=O)(=O)N2CCCN3C2c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K06 compound treatment 1.70065829E8 -7050000.0 -0.09 1.75631007E8 3650000.0 0.06 -0.0184 -0.1694 3064116 Maybridge4_002338 CSc1nc(/N=C/N(C)C)n2nc(cc2n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K07 compound treatment 1.68784465E8 -8340000.0 -0.1 1.82072803E8 1.01E7 0.17 0.0483 0.2389 3178660 Maybridge4_002339 CN(CCC#N)C(=S)Nc1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K08 compound treatment 1.83071657E8 5950000.0 0.07 1.80075965E8 8100000.0 0.14 0.1508 0.9579 3064117 Maybridge4_002340 COC(=O)c1scc(C#N)c1/N=C/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K09 compound treatment 1.67046395E8 -1.01E7 -0.13 1.7373283E8 1760000.0 0.03 -0.0681 -0.5244 1197958 Maybridge4_002341 CCN(CCS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K10 compound treatment 1.70477079E8 -6640000.0 -0.08 1.95466331E8 2.35E7 0.4 0.2254 0.5489 1372972 Maybridge4_002342 COc1ncccc1C(=O)Nc2ccc(F)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K11 compound treatment 1.90371044E8 1.33E7 0.17 1.91878222E8 1.99E7 0.34 0.3584 0.9456 3178661 Maybridge4_002343 CC(=O)Nc1c(Br)c(nn1c2ccccc2)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K12 compound treatment 1.65742628E8 -1.14E7 -0.14 1.98006276E8 2.6E7 0.45 0.2141 0.4577 3064118 Maybridge4_002344 O=S(=O)(/C(=C/c1ccc(\C=C(/C#N)\S(=O)(=O)c2ccccc2)cc1)/C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K13 compound treatment 1.88364332E8 1.12E7 0.14 1.89472822E8 1.75E7 0.3 0.3115 0.941 3178662 Maybridge4_002345 Oc1c2CN(C3CCCCC3)C(=O)c2nc4cc(nn14)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K14 compound treatment 1.88043039E8 1.09E7 0.14 2.06888022E8 3.49E7 0.6 0.5195 0.8473 1503351 Maybridge4_002346 CNC(=O)Nc1cccc(c1)c2ccnc(C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K15 compound treatment 1.58469798E8 -1.86E7 -0.23 1.71901476E8 -76300.0 0.0 -0.1664 -0.711 3178663 Maybridge4_002347 Clc1ccc(cc1)S(=O)(=O)/C(=C/c2ccccc2Cl)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K16 compound treatment 1.94057874E8 1.69E7 0.21 1.88787665E8 1.68E7 0.29 0.3537 0.9889 1326810 Maybridge4_002348 CC(C)S(=O)(=O)c1cnc(nc1N)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K17 compound treatment 1.10642244E8 -6.65E7 -0.83 1.86852756E8 1.49E7 0.25 -0.4096 -0.4698 3064119 Maybridge4_002349 CNC(=O)Nc1ccc(cc1)C2SCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K18 compound treatment 1.51335187E8 -2.58E7 -0.32 1.54133376E8 -1.78E7 -0.31 -0.4447 -0.9996 1218060 Maybridge4_002350 CCOC(=O)c1cnc2c(csc2c1Sc3ccc(Cl)cc3)S(=O)(=O)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K19 compound treatment 1.87558344E8 1.04E7 0.13 1.75202072E8 3220000.0 0.06 0.1316 0.9262 3064120 Maybridge4_002351 CSc1nc2cc(C)nn2c(c3ccco3)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K20 compound treatment 1.72046019E8 -5070000.0 -0.06 1.6816372E8 -3810000.0 -0.07 -0.0912 -0.9999 1209169 Maybridge4_002352 CS(=O)N(C(=O)c1scc(c1C)S(=O)(=O)c2ccc(Cl)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K21 compound treatment 1.74967108E8 -2150000.0 -0.03 1.70880561E8 -1100000.0 -0.02 -0.0324 -0.9843 1134325 Maybridge4_002353 COCc1cc(OC(=O)N(C)C)nc2n(C)nc(c3cccs3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K22 compound treatment 1.65435817E8 -1.17E7 -0.15 1.79870984E8 7890000.0 0.14 -0.0081 -0.0406 1310626 Maybridge4_002354 CCOC(=O)CSc1sc(C(=O)OCC)c-2c1S(=O)(=O)N(C)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K23 mock treatment 1.73619976E8 -3500000.0 -0.04 1.70625502E8 -1350000.0 -0.02 -0.0474 -0.9553 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 K24 mock treatment 1.89055476E8 1.19E7 0.15 1.67063258E8 -4910000.0 -0.08 0.0464 0.2701 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L01 compound treatment 1.48394862E8 -2.87E7 -0.36 1.63499864E8 -8480000.0 -0.15 -0.3574 -0.9201 3064121 Maybridge4_002355 CSc1sc(c2ccn(n2)C(=O)Nc3ccccc3)c4CC(C)(C)CC(=O)c14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L02 compound treatment 1.33292042E8 -4.38E7 -0.55 1.63061927E8 -8920000.0 -0.15 -0.4967 -0.8705 3178664 Maybridge4_002356 CS(=O)(=N/C=C(\C#N)/S(=O)(=O)c1ccc(cn1)C(F)(F)F)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L03 compound treatment 1.48043922E8 -2.91E7 -0.36 1.67771361E8 -4210000.0 -0.07 -0.3088 -0.8307 3064122 Maybridge4_002357 CSc1sc(C#N)c(C)c1C(=O)/C=C/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L04 compound treatment 1.46820267E8 -3.03E7 -0.38 1.64039224E8 -7940000.0 -0.14 -0.3649 -0.9039 3178665 Maybridge4_002358 CCOC(=O)c1sc(SCCS(=O)(=O)c2ccc(Cl)cc2)c3C(=O)CCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L05 compound treatment 1.26171133E8 -5.09E7 -0.64 1.69584411E8 -2390000.0 -0.04 -0.4809 -0.7509 1438715 Maybridge4_002359 Cc1c(C=C)c(sc1C(=O)Oc2ccccc2)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L06 compound treatment 1.26939612E8 -5.02E7 -0.63 1.65661701E8 -6320000.0 -0.11 -0.5216 -0.8166 3178666 Maybridge4_002360 CC1(C)CC(=O)c2c(SCCOC(=O)c3ccccc3Cl)sc(C#N)c2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L07 compound treatment 1.05618573E8 -7.15E7 -0.9 1.60349128E8 -1.16E7 -0.2 -0.775 -0.8435 3064123 Maybridge4_002361 Cc1nn(Cc2nc(cs2)C(C)(C)C)c(C)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L08 compound treatment 1.15852856E8 -6.13E7 -0.77 1.70456799E8 -1520000.0 -0.03 -0.5619 -0.7306 1009905 Maybridge4_002362 CC(=O)Nc1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L09 compound treatment 6.7077329E7 -1.1E8 -1.38 1.70522057E8 -1460000.0 -0.02 -0.9937 -0.7198 3178667 Maybridge4_002363 CSc1sc(c2CCCC(=O)c12)c3ccnc(SCC(=O)c4ccc(Cl)cc4)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L10 compound treatment 7.6906838E7 -1.0E8 -1.26 1.70083674E8 -1890000.0 -0.03 -0.9118 -0.7251 3064124 Maybridge4_002364 O=S1(=O)CC=C(C1)Sc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L11 compound treatment 8.9380087E7 -8.77E7 -1.1 1.76974216E8 5000000.0 0.09 -0.7178 -0.6502 3178668 Maybridge4_002365 Cc1cc(C)n(CCS(=O)(=O)c2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L12 compound treatment 6.2198378E7 -1.15E8 -1.44 1.56505937E8 -1.55E7 -0.26 -1.2067 -0.8232 3064125 Maybridge4_002366 Clc1ccc(cc1)C(=O)Nc2cc(cs2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L13 compound treatment 4.2180833E7 -1.35E8 -1.69 1.56033376E8 -1.59E7 -0.27 -1.3899 -0.8106 3178669 Maybridge4_002367 Cc1csc2sc(c(C)c12)c3ccnc(SCC(=O)NCc4ccccc4)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L14 compound treatment 5.8401951E7 -1.19E8 -1.49 1.73339814E8 1360000.0 0.02 -1.0366 -0.696 1344584 Maybridge4_002368 COC(=O)c1c(C)n2CSCc2c1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L15 compound treatment 3.1780425E7 -1.45E8 -1.82 1.21293555E8 -5.07E7 -0.87 -1.9027 -0.9423 3178670 Maybridge4_002369 CN(C)/C=C/C(=O)c1ccsc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L16 compound treatment 3.5907248E7 -1.41E8 -1.77 1.28034274E8 -4.39E7 -0.75 -1.7845 -0.9272 1542795 Maybridge4_002370 CCCCc1ccc(NC(=O)N=S2CCN(CC2)C(=O)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L17 compound treatment 4.0047483E7 -1.37E8 -1.72 1.45183956E8 -2.68E7 -0.46 -1.5402 -0.8655 1463535 Maybridge4_002371 CN1c2sc(C)c(C)c2C(=C(C(=O)Nc3ccc(Cl)cc3)S1(=O)=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L18 compound treatment 1.47752514E8 -2.94E7 -0.37 1.47977625E8 -2.4E7 -0.41 -0.551 -0.9985 1537505 Maybridge4_002372 Cc1occc1C(=O)C(=C(NCc2cccnc2)NCc3cccnc3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L19 compound treatment 1.8035497E8 3240000.0 0.04 1.60351281E8 -1.16E7 -0.2 -0.112 -0.5516 3064207 Maybridge4_002373 CS(=O)(=O)c1cc2cc(Cl)ccc2oc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L20 compound treatment 1.50187381E8 -2.69E7 -0.34 1.4353347E8 -2.84E7 -0.49 -0.5832 -0.9841 3064208 Maybridge4_002374 FC(F)(F)c1ccc(SC(=O)c2csc(n2)C3COc4ccccc4O3)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L21 compound treatment 1.7965775E8 2540000.0 0.03 1.64836201E8 -7140000.0 -0.12 -0.0639 -0.5061 3064209 Maybridge4_002375 CN(C)/C=N/C(=O)c1sc(c2C=CCCc12)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L22 compound treatment 1.10867397E8 -6.63E7 -0.83 1.71334122E8 -644000.0 -0.01 -0.5955 -0.7164 1320320 Maybridge4_002376 O=C(C1Cc2ccccc2C1)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L23 mock treatment 1.58077319E8 -1.9E7 -0.24 1.55920047E8 -1.61E7 -0.27 -0.3633 -0.9976 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 L24 mock treatment 1.8632011E8 9200000.0 0.12 1.78638928E8 6660000.0 0.11 0.1622 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M01 compound treatment 1.32715108E8 -4.44E7 -0.56 1.55312184E8 -1.67E7 -0.29 -0.5956 -0.9517 3064210 Maybridge4_002377 OC(=O)c1ccc2ccccc2c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M02 compound treatment 1.67851661E8 -9270000.0 -0.12 1.81908644E8 9930000.0 0.17 0.038 0.1845 3064211 Maybridge4_002378 Clc1ccc(cc1)S(=O)(=O)/C(=C/Nc2cccc(Cl)c2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M03 compound treatment 1.619788E8 -1.51E7 -0.19 1.70208132E8 -1770000.0 -0.03 -0.1557 -0.8096 3178671 Maybridge4_002379 COC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M04 compound treatment 1.58448481E8 -1.87E7 -0.23 1.6164058E8 -1.03E7 -0.18 -0.2907 -0.9904 3178672 Maybridge4_002380 CCOC(=O)/C(=C\Nc1ccc(F)c(Cl)c1)/S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M05 compound treatment 1.73735942E8 -3380000.0 -0.04 1.65046258E8 -6930000.0 -0.12 -0.1139 -0.904 3064212 Maybridge4_002381 Clc1ccc(/C=C/C(=O)Nc2cccc(Cl)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M06 compound treatment 1.71458681E8 -5660000.0 -0.07 1.55548505E8 -1.64E7 -0.28 -0.2491 -0.8587 3064213 Maybridge4_002382 NNC(=O)CS(=O)(=O)c1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M07 compound treatment 1.83430956E8 6310000.0 0.08 1.76205843E8 4230000.0 0.07 0.1072 0.999 3178673 Maybridge4_002383 Cc1cc(C)cc(NC(=S)Nc2cc(C)cc(C)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M08 compound treatment 1.93764118E8 1.66E7 0.21 1.68423937E8 -3550000.0 -0.06 0.1046 0.4811 3178674 Maybridge4_002384 Clc1ccc(SCC(=O)Nc2cscc2S(=O)(=O)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M09 compound treatment 1.73160878E8 -3960000.0 -0.05 1.48573812E8 -2.34E7 -0.4 -0.3184 -0.7887 1165743 Maybridge4_002385 CCN(CCS(=O)(=O)c1ccc(Cl)cc1)S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M10 compound treatment 1.70328244E8 -6790000.0 -0.09 1.4597462E8 -2.6E7 -0.45 -0.375 -0.8274 3178675 Maybridge4_002386 Clc1ccccc1NC(=S)Nc2cscc2S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M11 compound treatment 1.6781384E8 -9310000.0 -0.12 1.52369808E8 -1.96E7 -0.34 -0.3199 -0.9001 1302916 Maybridge4_002387 CC(C)(C)n1nc(cc1NC(=O)Nc2ccccc2)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M12 compound treatment 1.85474323E8 8350000.0 0.1 1.46323315E8 -2.57E7 -0.44 -0.2364 -0.5236 3178676 Maybridge4_002388 COC(=O)c1sc(SC)c(c1C)c2ccn(n2)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M13 compound treatment 1.68796452E8 -8320000.0 -0.1 1.51757788E8 -2.02E7 -0.35 -0.3186 -0.8812 3064215 Maybridge4_002389 COc1c(Cl)scc1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M14 compound treatment 1.68831851E8 -8290000.0 -0.1 1.60924069E8 -1.11E7 -0.19 -0.2073 -0.9602 3178677 Maybridge4_002390 CC(C)S(=O)(=O)c1csc(C(=O)NN)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M15 compound treatment 1.63779041E8 -1.33E7 -0.17 1.48848683E8 -2.31E7 -0.4 -0.3983 -0.9266 1619049 Maybridge4_002391 CC(C)(C)c1ccc(cc1)c2[nH]nc(NC(=O)c3ccccc3Cl)c2Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M16 compound treatment 1.69469677E8 -7650000.0 -0.1 1.54465585E8 -1.75E7 -0.3 -0.2798 -0.889 3178678 Maybridge4_002392 CSc1sc(C(=O)O)c(I)c1S(=O)(=O)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M17 compound treatment 1.62680992E8 -1.44E7 -0.18 1.52285078E8 -1.97E7 -0.34 -0.3664 -0.9576 3178679 Maybridge4_002393 CC(C)(C)c1ccc(cc1)C(=O)C(=C2SCCCS2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M18 compound treatment 1.78739827E8 1620000.0 0.02 1.6041712E8 -1.16E7 -0.2 -0.1256 -0.6312 3064216 Maybridge4_002394 CS(=O)(=NC(=O)Nc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M19 compound treatment 1.75003105E8 -2120000.0 -0.03 1.50231671E8 -2.17E7 -0.37 -0.282 -0.7556 3178680 Maybridge4_002395 CSc1nc2cc(C)nn2c(c1C#N)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M20 compound treatment 1.68033672E8 -9090000.0 -0.11 1.46125009E8 -2.59E7 -0.44 -0.3935 -0.8611 1447748 Maybridge4_002396 Clc1ccccc1c2csc(CS(=O)(=O)c3cccs3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M21 compound treatment 1.77361196E8 242000.0 0.0 1.60754851E8 -1.12E7 -0.19 -0.1337 -0.6959 3178681 Maybridge4_002397 CSc1nc(N)n2nc(cc2n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M22 compound treatment 1.25002065E8 -5.21E7 -0.65 1.24053012E8 -4.79E7 -0.82 -1.0424 -0.9937 3178753 Maybridge4_002398 CN(C)/C=C/C(=O)c1sc(SCc2ccc(Cl)cc2)c3C(=O)CC(C)(C)Cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M23 mock treatment 1.61525058E8 -1.56E7 -0.2 1.50172471E8 -2.18E7 -0.37 -0.4023 -0.9545 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 M24 mock treatment 1.63029249E8 -1.41E7 -0.18 1.53243754E8 -1.87E7 -0.32 -0.3517 -0.9606 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N01 compound treatment 1.82292248E8 5170000.0 0.06 1.49086853E8 -2.29E7 -0.39 -0.2312 -0.5821 3064217 Maybridge4_002399 CCOC(=O)c1sc2sc(C(=O)OCC)c(c3ccc(Cl)cc3)c2c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N02 compound treatment 1.55455362E8 -2.17E7 -0.27 1.4196213E8 -3.0E7 -0.51 -0.5555 -0.9557 3064244 Maybridge4_002400 CCOC(=O)NS(=O)(=O)c1ccc(s1)c2cc(n(C)n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N03 compound treatment 1.76106943E8 -1010000.0 -0.01 1.36675165E8 -3.53E7 -0.6 -0.4363 -0.7218 3064245 Maybridge4_002401 CSc1scc2CC(C)(C)CC(=O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N04 compound treatment 1.76811252E8 -308000.0 0.0 1.38578123E8 -3.34E7 -0.57 -0.407 -0.7119 3064246 Maybridge4_002402 CC1(C)CCc2cc(ccc2O1)C3SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N05 compound treatment 1.12132187E8 -6.5E7 -0.82 1.56322553E8 -1.57E7 -0.27 -0.766 -0.8926 3064248 Maybridge4_002403 Cc1nn(CC(=S)N)c(C)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N06 compound treatment 1.21684994E8 -5.54E7 -0.7 1.55077324E8 -1.69E7 -0.29 -0.6963 -0.9245 1138975 Maybridge4_002404 CC(C)S(=O)(=O)c1cscc1N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N07 compound treatment 1.50609985E8 -2.65E7 -0.33 1.42324794E8 -2.97E7 -0.51 -0.5941 -0.979 3064249 Maybridge4_002405 Fc1cccc(NC(=S)N(CCS(=O)(=O)c2ccc(Cl)cc2)Cc3cccs3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N08 compound treatment 1.66780933E8 -1.03E7 -0.13 1.35319461E8 -3.67E7 -0.63 -0.5354 -0.8356 3064250 Maybridge4_002406 Clc1ccc(C(=O)C2C(=O)CCC(C2=O)c3ccccc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N09 compound treatment 1.65958842E8 -1.12E7 -0.14 1.33539735E8 -3.84E7 -0.66 -0.5643 -0.8388 3064251 Maybridge4_002407 CSc1sc(c2CC(C)(C)CC(=O)c12)c3ccnc(SCC(=O)C(C)(C)C)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N10 compound treatment 1.15599783E8 -6.15E7 -0.77 1.50562568E8 -2.14E7 -0.37 -0.8049 -0.9421 1318871 Maybridge4_002408 Cn1ccnc1SCCS(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N11 compound treatment 1.1681553E8 -6.03E7 -0.76 1.57110459E8 -1.49E7 -0.25 -0.7149 -0.8957 1250473 Maybridge4_002409 CCOC(=O)c1sc(SCc2ccccc2)c3c1-c4sccc4N(C)S3(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N12 compound treatment 1.25110842E8 -5.2E7 -0.65 1.51025706E8 -2.1E7 -0.36 -0.7149 -0.9603 3064253 Maybridge4_002410 FC(F)(F)c1cc(cc(c1)S(=O)(=O)/N=S\2/CCC3(C2)OCCO3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N13 compound treatment 1.35301233E8 -4.18E7 -0.52 1.45344187E8 -2.66E7 -0.46 -0.6933 -0.9976 1662782 Maybridge4_002411 CSc1sc(c2nc(cs2)C(C)(C)C)c3CCCC(=O)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N14 compound treatment 1.48304198E8 -2.88E7 -0.36 1.26945816E8 -4.5E7 -0.77 -0.8007 -0.9404 1607185 Maybridge4_002412 Clc1ccc(cc1)C(=O)N=S2CCN(CC2)C(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N15 compound treatment 1.87264864E8 1.01E7 0.13 1.61648342E8 -1.03E7 -0.18 -0.035 -0.1608 3178754 Maybridge4_002413 COC(=O)C1=C(CSC1)Nc2ccc(OC(=O)c3cccc(c3)C(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N16 compound treatment 1.86684532E8 9560000.0 0.12 1.52424282E8 -1.96E7 -0.33 -0.1518 -0.427 1495489 Maybridge4_002414 Clc1ccc(OC(=O)c2cccnc2SCCS(=O)(=O)c3ccccc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N17 compound treatment 1.8104909E8 3930000.0 0.05 1.46021211E8 -2.6E7 -0.44 -0.2793 -0.6248 3178755 Maybridge4_002415 CSc1sc(C(=O)NN)c2CCC=Cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N18 compound treatment 1.84517109E8 7400000.0 0.09 1.48949663E8 -2.3E7 -0.39 -0.2131 -0.5263 3178756 Maybridge4_002416 CS(=O)(=NS(=O)(=O)c1cccs1)c2ccc(OC(=O)c3ccc(Cl)cc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N19 compound treatment 1.81353519E8 4230000.0 0.05 1.42211681E8 -2.98E7 -0.51 -0.3227 -0.63 3064254 Maybridge4_002417 CS(=O)(=O)/C(=C/Nc1cnccn1)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N20 compound treatment 1.84974634E8 7850000.0 0.1 1.68030707E8 -3950000.0 -0.07 0.0219 0.1833 1627111 Maybridge4_002418 O=C(SCc1cccs1)c2csc(n2)C3COc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N21 compound treatment 1.9448839E8 1.74E7 0.22 1.73210013E8 1230000.0 0.02 0.169 0.772 3064255 Maybridge4_002419 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)CCN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N22 compound treatment 1.73155355E8 -3960000.0 -0.05 1.63204856E8 -8770000.0 -0.15 -0.1414 -0.8935 3178757 Maybridge4_002420 Clc1ccc(cc1)c2cc(NC(=O)C3Cc4ccccc4C3)[nH]n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N23 mock treatment 1.71471136E8 -5650000.0 -0.07 1.64740923E8 -7240000.0 -0.12 -0.1377 -0.9649 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 N24 mock treatment 1.66266971E8 -1.09E7 -0.14 1.56712283E8 -1.53E7 -0.26 -0.281 -0.9538 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O01 compound treatment 1.19463052E8 -5.77E7 -0.72 1.31181533E8 -4.08E7 -0.7 -1.0052 -0.9998 1259648 Maybridge4_002421 COc1ccc(NC(=O)C(C(=O)Nc2ccc(OC)cc2)C3(CC4CC5CC(C4)C3)C5)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O02 compound treatment 1.0229456E8 -7.48E7 -0.94 1.23524755E8 -4.85E7 -0.83 -1.2502 -0.9981 3064256 Maybridge4_002422 FC(F)(F)c1cc(N/C=C(\C#N)/S(=O)(=O)c2ccccn2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O03 compound treatment 1.23402845E8 -5.37E7 -0.67 1.36885889E8 -3.51E7 -0.6 -0.9012 -0.9984 1743228 Maybridge4_002423 Cc1ccc(Nc2cc(O)nn2C)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O04 compound treatment 1.31883713E8 -4.52E7 -0.57 1.26498186E8 -4.55E7 -0.78 -0.9518 -0.9879 3064257 Maybridge4_002424 CCn1c(S)nc2ccccc2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O05 compound treatment 1.38669819E8 -3.84E7 -0.48 1.35528181E8 -3.64E7 -0.62 -0.7823 -0.9919 3178758 Maybridge4_002425 Cc1c(C)c(C)c(CSc2ccccc2N)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O06 compound treatment 1.28167011E8 -4.9E7 -0.61 1.15353432E8 -5.66E7 -0.97 -1.1196 -0.9757 3064258 Maybridge4_002426 CS/C(=C(\C#N)/C(=O)C1CC1)/N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O07 compound treatment 1.36013241E8 -4.11E7 -0.52 1.30629763E8 -4.13E7 -0.71 -0.8651 -0.9879 1286597 Maybridge4_002427 O=S(=O)(CCN1CCSCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O08 compound treatment 1.26310176E8 -5.08E7 -0.64 1.26199014E8 -4.58E7 -0.78 -1.0048 -0.9947 3064259 Maybridge4_002428 Clc1ccccc1C(=O)Nc2cscc2S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O09 compound treatment 1.24019715E8 -5.31E7 -0.67 1.24137311E8 -4.78E7 -0.82 -1.0501 -0.9947 3178759 Maybridge4_002429 O=S(=O)(CCSc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O10 compound treatment 1.179794E8 -5.91E7 -0.74 1.17940258E8 -5.4E7 -0.93 -1.1787 -0.994 1558086 Maybridge4_002430 COC(=O)C1=C(CSC1)Nc2ccc(F)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O11 compound treatment 1.18063736E8 -5.91E7 -0.74 1.24074878E8 -4.79E7 -0.82 -1.1037 -0.9987 3064260 Maybridge4_002431 Cc1cc(C)n2nc(cc2n1)c3ccc(cc3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O12 compound treatment 1.30443856E8 -4.67E7 -0.59 1.14294414E8 -5.77E7 -0.99 -1.1122 -0.9689 3178760 Maybridge4_002432 CC(C)S(=O)(=O)c1csc(C(=O)OCC(=O)c2ccc(Cl)cc2)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O13 compound treatment 1.20165724E8 -5.7E7 -0.71 1.13121533E8 -5.89E7 -1.01 -1.2176 -0.9858 3064262 Maybridge4_002433 Clc1ccc(cc1)S(=O)(=O)/C(=C/N2CCCCC2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O14 compound treatment 1.26719317E8 -5.04E7 -0.63 1.15473499E8 -5.65E7 -0.97 -1.131 -0.9788 3178761 Maybridge4_002434 Fc1ccc(NC(=O)c2cccnc2Sc3cccs3)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O15 compound treatment 1.22331041E8 -5.48E7 -0.69 1.20157057E8 -5.18E7 -0.89 -1.1132 -0.992 3064263 Maybridge4_002435 Nc1nc(Sc2ccc(Cl)cc2)c(C#N)c(c1C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O16 compound treatment 1.2868614E8 -4.84E7 -0.61 1.30041804E8 -4.19E7 -0.72 -0.9372 -0.9966 3178762 Maybridge4_002436 CSc1scc(c1C#N)c2cc(Cl)cc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O17 compound treatment 1.22225629E8 -5.49E7 -0.69 1.26461306E8 -4.55E7 -0.78 -1.0379 -0.9981 3064280 Maybridge4_002437 O=C(C(=C1SCCCS1)C#N)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O18 compound treatment 1.18905798E8 -5.82E7 -0.73 1.23330818E8 -4.86E7 -0.83 -1.1052 -0.9979 3064281 Maybridge4_002438 CN(/N=C(\C#N)/C(=O)C1CC1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O19 compound treatment 1.24165444E8 -5.3E7 -0.66 1.3002178E8 -4.2E7 -0.72 -0.9776 -0.9992 1358615 Maybridge4_002439 COCc1cc(OC(=O)N(C)C)nc2n(C)nc(C)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O20 compound treatment 1.2935746E8 -4.78E7 -0.6 1.29328608E8 -4.26E7 -0.73 -0.9399 -0.9952 1379175 Maybridge4_002440 Cn1ccc(n1)c2cccc(NC(=O)Nc3ccccc3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O21 compound treatment 1.37144394E8 -4.0E7 -0.5 1.26584977E8 -4.54E7 -0.78 -0.904 -0.9776 3064282 Maybridge4_002441 CSc1c(C#N)c(nn1CNC(=O)Nc2ccccc2C(F)(F)F)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O22 compound treatment 1.19521404E8 -5.76E7 -0.72 1.20065822E8 -5.19E7 -0.89 -1.1393 -0.9947 3064283 Maybridge4_002442 CCOC(=O)c1sc(SCc2c(Cl)cccc2Cl)c(c1N)S(=O)(=O)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O23 mock treatment 1.19497958E8 -5.76E7 -0.72 1.23482792E8 -4.85E7 -0.83 -1.0981 -0.9976 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 O24 mock treatment 1.33254441E8 -4.39E7 -0.55 1.29339305E8 -4.26E7 -0.73 -0.9052 -0.9903 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P01 compound treatment 1.27109028E8 -5.0E7 -0.63 1.36605916E8 -3.54E7 -0.61 -0.8718 -0.9998 3064285 Maybridge4_002443 Nc1c(C#N)sc2sc(C#N)c(c3ccco3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P02 compound treatment 1.52066299E8 -2.51E7 -0.31 1.43035768E8 -2.89E7 -0.5 -0.5726 -0.9759 3064286 Maybridge4_002444 CC(C)(C)c1ncc(c(N)n1)S(=O)(=O)c2ccc(cn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P03 compound treatment 1.34225535E8 -4.29E7 -0.54 1.30562638E8 -4.14E7 -0.71 -0.8818 -0.9907 3178763 Maybridge4_002445 CCOC(=O)c1sc(SC)c2C(=O)CC(Cc12)c3ccc(OC)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P04 compound treatment 1.29652171E8 -4.75E7 -0.6 1.31127594E8 -4.09E7 -0.7 -0.9155 -0.9968 3178764 Maybridge4_002446 CCOC(=O)c1sc(Sc2ccc(cn2)C(F)(F)F)c3C(=O)CC(C)(C)Cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P05 compound treatment 1.30435577E8 -4.67E7 -0.59 1.23123768E8 -4.89E7 -0.84 -1.0054 -0.9848 1299033 Maybridge4_002447 CS(=O)(=O)c1sc(C(=O)O)c2CCC=Cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P06 compound treatment 1.26310679E8 -5.08E7 -0.64 1.24059853E8 -4.79E7 -0.82 -1.0307 -0.9922 1436320 Maybridge4_002448 Cc1cc(C)n(n1)c2ncc(c(N)n2)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P07 compound treatment 1.38216507E8 -3.89E7 -0.49 1.28694828E8 -4.33E7 -0.74 -0.869 -0.9795 3178765 Maybridge4_002449 CSc1scc2CCc3cn(nc3-c12)C(=O)c4cccc(c4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P08 compound treatment 1.24422774E8 -5.27E7 -0.66 1.33737688E8 -3.82E7 -0.65 -0.9303 -1.0 3178766 Maybridge4_002450 CS(=O)(=NC(=O)NC(=O)c1ccc(Cl)cc1)c2ccc(cn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P09 compound treatment 1.37465406E8 -3.97E7 -0.5 1.31984472E8 -4.0E7 -0.68 -0.8358 -0.9877 3064288 Maybridge4_002451 O=S(=O)(N1CCCCC1)c2ccc(s2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P10 compound treatment 1.24786679E8 -5.23E7 -0.66 1.29452601E8 -4.25E7 -0.73 -0.9789 -0.9987 3064289 Maybridge4_002452 COC(=O)c1cnc(S)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P11 compound treatment 1.16198416E8 -6.09E7 -0.76 1.17469233E8 -5.45E7 -0.93 -1.2002 -0.9951 3178767 Maybridge4_002453 FC(F)(F)c1cc(NC(=S)NC(=O)Oc2ccccc2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P12 compound treatment 1.24512325E8 -5.26E7 -0.66 1.230406E8 -4.89E7 -0.84 -1.059 -0.993 3064290 Maybridge4_002454 Cc1ccc(SCC(=O)c2ccc(CC(=O)O)s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P13 compound treatment 1.23601776E8 -5.35E7 -0.67 1.27102516E8 -4.49E7 -0.77 -1.0179 -0.9977 3178768 Maybridge4_002455 CS(=O)(=NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P14 compound treatment 9.9986611E7 -7.71E7 -0.97 9.8511137E7 -7.35E7 -1.26 -1.5735 -0.9916 3064291 Maybridge4_002456 CN(C)/C=C/C(=O)c1ccc2OCCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P15 compound treatment 1.17433371E8 -5.97E7 -0.75 1.20180468E8 -5.18E7 -0.89 -1.1564 -0.9965 3178769 Maybridge4_002457 Cc1cc2ncc(c(C)n2n1)c3ccnc(SCc4c(Cl)cccc4Cl)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P16 compound treatment 1.37828123E8 -3.93E7 -0.49 1.41290436E8 -3.07E7 -0.53 -0.72 -0.9995 3064292 Maybridge4_002458 CS(=O)(=O)CCSc1ncccc1C(=O)NCc2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P17 compound treatment 1.18384145E8 -5.87E7 -0.74 1.11541097E8 -6.04E7 -1.03 -1.2525 -0.9862 1476633 Maybridge4_002459 CCOC(=O)c1sc(N2CCCCC2)c3C(=O)CC(C)(C)Cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P18 compound treatment 1.36907946E8 -4.02E7 -0.5 1.29556199E8 -4.24E7 -0.73 -0.8702 -0.9842 3064293 Maybridge4_002460 OC(=O)C1Cc2ccccc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P19 compound treatment 1.25358172E8 -5.18E7 -0.65 1.13752837E8 -5.82E7 -1.0 -1.1639 -0.9784 3178770 Maybridge4_002461 FC(F)(F)c1ccc(nc1)S(=O)(=O)/C(=C/Nc2cnccn2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P20 compound treatment 1.16047992E8 -6.11E7 -0.77 1.22300423E8 -4.97E7 -0.85 -1.143 -0.9986 1356891 Maybridge4_002462 CCOC(=O)CC1Sc2ccccc2N=C1SCC(=O)Nc3ccc(Cl)cc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P21 compound treatment 1.34300329E8 -4.28E7 -0.54 1.33815325E8 -3.82E7 -0.65 -0.8417 -0.9953 3064294 Maybridge4_002463 Clc1ccc(Sc2ccc(s2)c3ccccn3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P22 compound treatment 1.28372553E8 -4.87E7 -0.61 1.36752241E8 -3.52E7 -0.6 -0.8588 -1.0 1623679 Maybridge4_002464 Cc1ccc(NC(=O)c2ccc3OCCc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P23 mock treatment 1.32613118E8 -4.45E7 -0.56 1.26549256E8 -4.54E7 -0.78 -0.9447 -0.9868 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2055 P24 mock treatment 1.32532741E8 -4.46E7 -0.56 1.23902269E8 -4.81E7 -0.82 -0.9774 -0.9823 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A01 compound treatment 2.09993975E8 5.57E7 0.7 1.97222862E8 3.29E7 0.56 0.8924 0.9942 3178771 Maybridge4_002465 FC(F)(F)c1ccc(NC(=O)c2ccc3OCCc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A02 compound treatment 2.13439286E8 5.92E7 0.74 1.97572932E8 3.32E7 0.57 0.9271 0.9914 3178772 Maybridge4_002466 COc1cc(nc2ccc(C)c(NC(=O)Nc3ccc(OC(F)(F)F)cc3)c12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A03 compound treatment 2.24542073E8 7.03E7 0.88 2.04741536E8 4.04E7 0.69 1.1124 0.9928 1345781 Maybridge4_002467 O=C1N(CC2COc3ccccc3O2)C(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A04 compound treatment 2.19390143E8 6.51E7 0.82 1.98242914E8 3.39E7 0.58 0.988 0.986 1377469 Maybridge4_002468 CN(C)CC#Cc1cncc(c1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A05 compound treatment 2.11407832E8 5.71E7 0.72 1.92853214E8 2.85E7 0.49 0.852 0.9825 1734397 Maybridge4_002469 Brc1cc2CCOc2c(c1)C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A06 compound treatment 2.28032453E8 7.38E7 0.93 2.02909116E8 3.86E7 0.66 1.1212 0.9863 3178773 Maybridge4_002470 FC(F)(F)c1ccc2cc(CSc3ccc(Cl)cc3)ccc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A07 compound treatment 2.18525032E8 6.43E7 0.81 2.02292486E8 3.8E7 0.65 1.0294 0.9943 3064295 Maybridge4_002471 COc1ccc(OC(=O)c2csc(COc3ccc4nonc4c3)n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A08 compound treatment 2.24942147E8 7.07E7 0.89 2.1402513E8 4.97E7 0.85 1.2283 0.9998 1124957 Maybridge4_002472 Fc1ccc(cc1)S(=O)(=O)CCN2CCC(CC2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A09 compound treatment 1.48232209E8 -6040000.0 -0.08 1.33273608E8 -3.11E7 -0.53 -0.4296 -0.7998 3064326 Maybridge4_002473 Cc1nn(Cc2ccc(o2)C(=O)Sc3ccc(cn3)C(F)(F)F)c(C)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A10 compound treatment 2.01329561E8 4.71E7 0.59 1.94297527E8 3.0E7 0.51 0.7801 0.9975 1618157 Maybridge4_002474 CCOC(=O)c1c(SC)nc2ccc(Cl)cc2c1N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A11 compound treatment 1.98313504E8 4.4E7 0.55 1.98463592E8 3.41E7 0.58 0.8038 0.9996 1711585 Maybridge4_002475 CCOC(=O)NC(=O)c1cn(Cc2cccs2)c(=O)n(C)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A12 compound treatment 1.74093076E8 1.98E7 0.25 1.7448451E8 1.02E7 0.17 0.2987 0.9846 3064327 Maybridge4_002476 FC(F)(F)c1cc(N2CCN(CC2)C(=O)c3cccs3)c4ccccc4n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A13 compound treatment 1.79113087E8 2.48E7 0.31 1.65516326E8 1180000.0 0.02 0.2346 0.7514 3064329 Maybridge4_002477 Cc1ccc(cc1)S(=O)(=O)NCCSc2cc(nc3ccccc23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A14 compound treatment 2.01085653E8 4.68E7 0.59 1.96198767E8 3.19E7 0.55 0.8009 0.9993 3064330 Maybridge4_002478 Clc1ccc(NC(=O)OCC#Cc2ccc(C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A15 compound treatment 1.85496649E8 3.12E7 0.39 1.85296695E8 2.1E7 0.36 0.5307 0.999 3064331 Maybridge4_002479 COC(=O)c1scc2c(SCc3ccccc3)cc(nc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A16 compound treatment 2.01246225E8 4.7E7 0.59 2.1484453E8 5.05E7 0.86 1.0281 0.9825 3178850 Maybridge4_002480 CCCNC(=O)Nc1ccc(OC(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A17 compound treatment 1.87894625E8 3.36E7 0.42 2.03964604E8 3.96E7 0.68 0.7779 0.9739 1220133 Maybridge4_002481 COC(=O)c1sccc1n2cc(C#N)c(=O)n(C)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A18 compound treatment 1.90570023E8 3.63E7 0.46 2.00670452E8 3.63E7 0.62 0.7618 0.9882 1288518 Maybridge4_002482 O=c1[nH]nc(CSc2ccccn2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A19 compound treatment 1.82164073E8 2.79E7 0.35 1.96416288E8 3.21E7 0.55 0.6357 0.9763 1196923 Maybridge4_002483 Cn1c(=O)c(cn(c2ccccc2)c1=O)C(=S)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A20 compound treatment 1.81516041E8 2.72E7 0.34 1.95779781E8 3.14E7 0.54 0.6223 0.976 3178851 Maybridge4_002484 COc1ccc(NC(=O)N(Cc2ccccc2)C(=O)CC#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A21 compound treatment 1.89784854E8 3.55E7 0.45 2.01114603E8 3.68E7 0.63 0.7602 0.9856 1562266 Maybridge4_002485 Clc1ccccc1C(=O)CSC2=NCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A22 compound treatment 1.86947956E8 3.27E7 0.41 2.031696E8 3.88E7 0.66 0.7599 0.973 3064332 Maybridge4_002486 FC(F)(F)c1cc(Oc2ccc(Cl)cc2)c3cc(Cl)ccc3n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A23 mock treatment 1.86090415E8 3.18E7 0.4 1.91410815E8 2.71E7 0.46 0.61 0.9972 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 A24 mock treatment 1.82389072E8 2.81E7 0.35 2.09578963E8 4.52E7 0.77 0.797 0.9366 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B01 compound treatment 1.70608153E8 1.63E7 0.2 1.7006621E8 5730000.0 0.1 0.2143 0.9431 1234192 Maybridge4_002487 Cc1nc(ncc1S(=O)(=O)c2ccc(Cl)cc2)C3COc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B02 compound treatment 1.91428358E8 3.72E7 0.47 1.83464993E8 1.91E7 0.33 0.5611 0.9851 3064333 Maybridge4_002488 COC(=O)c1cc2cc(Br)ccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B03 compound treatment 2.14505873E8 6.02E7 0.76 1.93019671E8 2.87E7 0.49 0.8815 0.9782 1523364 Maybridge4_002489 Cc1ccccc1NC(=O)NCCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B04 compound treatment 1.91947645E8 3.77E7 0.47 1.92890086E8 2.86E7 0.49 0.6798 0.9999 3064334 Maybridge4_002490 Cc1c(sc2ccc(Cl)cc12)C(=O)COC(=O)c3ccccc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B05 compound treatment 1.91479706E8 3.72E7 0.47 1.52489232E8 -1.18E7 -0.2 0.1867 0.3668 3178852 Maybridge4_002491 Cc1cccc(C)c1NC(=O)N(Cc2ccccc2)C(=O)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B06 compound treatment 1.50009914E8 -4260000.0 -0.05 1.47983363E8 -1.64E7 -0.28 -0.2357 -0.8273 3064335 Maybridge4_002492 Cc1c(sc2ccccc12)c3ccnn3C(=O)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B07 compound treatment 1.87727929E8 3.35E7 0.42 1.96787979E8 3.25E7 0.56 0.6896 0.9904 1235231 Maybridge4_002493 COC(=O)c1ccc(CN(C(=O)C)C(=O)Nc2ccc(cc2C)C(=O)OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B08 compound treatment 1.88717016E8 3.44E7 0.43 2.01607049E8 3.73E7 0.64 0.7567 0.982 3178853 Maybridge4_002494 Clc1ccccc1NC(=S)N2CCOC2c3c[nH]c4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B09 compound treatment 1.73930016E8 1.97E7 0.25 1.79176645E8 1.48E7 0.25 0.354 0.9999 3064336 Maybridge4_002495 C=CCn1c(SCc2ccccc2)nnc1c3ccc4ncccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B10 compound treatment 1.82539977E8 2.83E7 0.35 1.9281754E8 2.85E7 0.49 0.5955 0.9878 3064337 Maybridge4_002496 O=C(CCSc1ccccc1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B11 compound treatment 1.89730712E8 3.55E7 0.44 1.97372511E8 3.3E7 0.57 0.7144 0.9929 3178854 Maybridge4_002497 CC(C)n1c(nc2cc(ccc12)C(=O)Nc3ccc(Cl)cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B12 compound treatment 1.75922899E8 2.16E7 0.27 1.82621932E8 1.83E7 0.31 0.4134 0.9975 1241391 Maybridge4_002498 Clc1cccc(NC(=O)OC2CCCCc3cccnc23)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B13 compound treatment 1.88206671E8 3.39E7 0.43 1.93352327E8 2.9E7 0.5 0.6522 0.997 1376937 Maybridge4_002499 CCc1ccc2[nH]c(cc2c1)C(=O)NCCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B14 compound treatment 1.88190291E8 3.39E7 0.43 2.01257927E8 3.69E7 0.63 0.7478 0.9814 3178855 Maybridge4_002500 FC(F)(F)COc1ccc(Sc2ncccn2)c(OCC(F)(F)F)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B15 compound treatment 1.85736073E8 3.15E7 0.39 2.00423098E8 3.61E7 0.62 0.7159 0.9766 1581778 Maybridge4_002501 Clc1ccc(cc1)c2ccc(s2)C(=O)NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B16 compound treatment 1.80175939E8 2.59E7 0.32 2.02469083E8 3.81E7 0.65 0.6914 0.9481 1626834 Maybridge4_002502 C(N1CCC(=N1)c2ccco2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B17 compound treatment 1.90852414E8 3.66E7 0.46 2.02878917E8 3.85E7 0.66 0.791 0.9842 3064338 Maybridge4_002503 O=C(NC(=S)NCc1ccccc1)/C=C/c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B18 compound treatment 1.81057532E8 2.68E7 0.34 1.92361335E8 2.8E7 0.48 0.5768 0.9848 3178856 Maybridge4_002504 OCCn1nc(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B19 compound treatment 1.99783055E8 4.55E7 0.57 2.06659801E8 4.23E7 0.72 0.916 0.993 1406037 Maybridge4_002505 COc1ccc(cc1)c2csc(n2)c3ccc(OC)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B20 compound treatment 1.89874661E8 3.56E7 0.45 2.12663887E8 4.83E7 0.83 0.9008 0.9581 1528457 Maybridge4_002506 COc1ccc(cc1)c2nn(CCC#N)c(=O)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B21 compound treatment 1.88986711E8 3.47E7 0.44 2.07042309E8 4.27E7 0.73 0.8249 0.9694 3064339 Maybridge4_002507 Cc1ccc(CC(=O)c2cccnc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B22 compound treatment 1.86470552E8 3.22E7 0.4 1.95321075E8 3.1E7 0.53 0.6607 0.991 3178857 Maybridge4_002508 CCOC(=O)NC(=S)N1C(C)CCCC1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B23 mock treatment 1.80660071E8 2.64E7 0.33 1.9496006E8 3.06E7 0.52 0.6048 0.9754 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 B24 mock treatment 1.80399935E8 2.61E7 0.33 1.96928388E8 3.26E7 0.56 0.6263 0.9678 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C01 compound treatment 1.50169826E8 -4100000.0 -0.05 1.54571329E8 -9760000.0 -0.17 -0.1546 -0.8839 3178858 Maybridge4_002509 Cn1c(S)nnc1C2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C02 compound treatment 1.53672287E8 -601000.0 -0.01 1.65549293E8 1210000.0 0.02 0.0094 0.4238 3064341 Maybridge4_002510 CCOC(=O)c1cncc(C#CCOC(=O)Nc2cc(Cl)cc(Cl)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C03 compound treatment 1.51509212E8 -2760000.0 -0.03 1.60041767E8 -4290000.0 -0.07 -0.0765 -0.9412 1514783 Maybridge4_002511 Clc1ccc(cc1)C(=O)NCC2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C04 compound treatment 1.58287091E8 4010000.0 0.05 1.68469291E8 4130000.0 0.07 0.0857 0.9861 3064342 Maybridge4_002512 CSc1nn(cc1c2nc(cs2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C05 compound treatment 1.6178784E8 7510000.0 0.09 1.66117741E8 1780000.0 0.03 0.0882 0.8906 3064366 Maybridge4_002513 COc1cccn(CC(=O)NN)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C06 compound treatment 1.57152633E8 2880000.0 0.04 1.58171618E8 -6160000.0 -0.11 -0.0491 -0.4399 3064367 Maybridge4_002514 Clc1ccc(Cl)c(c1)S(=O)(=O)n2ccc(n2)c3ccc(Br)s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C07 compound treatment 1.68591134E8 1.43E7 0.18 1.71945311E8 7610000.0 0.13 0.2191 0.9876 1600605 Maybridge4_002515 Clc1ccc(NC(=O)c2csc(COc3ccc4nonc4c3)n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C08 compound treatment 1.57551287E8 3280000.0 0.04 1.61557281E8 -2780000.0 -0.05 -0.0045 -0.0722 1505462 Maybridge4_002516 Cc1ccc(cc1)S(=O)(=O)CCN2CCC(CC2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C09 compound treatment 1.45155958E8 -9120000.0 -0.11 1.47595154E8 -1.67E7 -0.29 -0.2835 -0.9189 3064368 Maybridge4_002517 CSc1nc2ccc(NS(=O)(=O)c3ccccc3C(F)(F)F)cc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C10 compound treatment 1.47841273E8 -6430000.0 -0.08 1.5188671E8 -1.24E7 -0.21 -0.2077 -0.9117 3064369 Maybridge4_002518 CCOC(=O)c1c(SC)nc2c(cccc2c1N3CCCC3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C11 compound treatment 1.48920279E8 -5350000.0 -0.07 1.48848099E8 -1.55E7 -0.27 -0.2349 -0.8591 3064371 Maybridge4_002519 Cn1c(S)nnc1CSc2cc(nc3ccccc23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C12 compound treatment 1.28081408E8 -2.62E7 -0.33 1.27731229E8 -3.66E7 -0.63 -0.6754 -0.9546 3064373 Maybridge4_002520 FC(F)(F)c1cccc(c1)N2C(=O)C3SCCN3C2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C13 compound treatment 1.34503117E8 -1.98E7 -0.25 1.37310296E8 -2.7E7 -0.46 -0.5025 -0.9573 3178859 Maybridge4_002521 O=C(Nc1ccccc1)OCC#Cc2ccc(s2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C14 compound treatment 1.43775668E8 -1.05E7 -0.13 1.3640158E8 -2.79E7 -0.48 -0.4312 -0.8695 3064374 Maybridge4_002522 FC(F)(F)Oc1ccc(NC(=O)OCC#Cc2ccc(C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C15 compound treatment 1.22452967E8 -3.18E7 -0.4 8.076816E7 -8.36E7 -1.43 -1.2938 -0.8711 1566879 Maybridge4_002523 CCOC(=O)Cn1c(=O)c(cn(C(C)C)c1=O)c2nc(cs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C16 compound treatment 1.39428538E8 -1.48E7 -0.19 1.24880682E8 -3.95E7 -0.68 -0.6092 -0.8696 1528772 Maybridge4_002524 Cc1ccc(OC(=O)c2c(nnc3ccccc23)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C17 compound treatment 1.41630744E8 -1.26E7 -0.16 1.37301142E8 -2.7E7 -0.46 -0.4394 -0.8982 1617239 Maybridge4_002525 Clc1ccc(Cn2ccnc2COC(=O)Nc3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C18 compound treatment 1.46430141E8 -7840000.0 -0.1 1.46274851E8 -1.81E7 -0.31 -0.2882 -0.8883 1164357 Maybridge4_002526 COC(=O)CSCc1n[nH]c(=O)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C19 compound treatment 1.48780748E8 -5490000.0 -0.07 1.48536104E8 -1.58E7 -0.27 -0.2399 -0.8598 3178860 Maybridge4_002527 Cn1c(=O)c(cn(c2ccccc2)c1=O)/C(=N/O)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C20 compound treatment 1.55538641E8 1270000.0 0.02 1.6693937E8 2610000.0 0.04 0.0428 0.9033 3178861 Maybridge4_002528 Fc1cccc(NC(=O)N(Cc2ccccc2)C(=O)CC#N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C21 compound treatment 1.49341835E8 -4930000.0 -0.06 1.45898412E8 -1.84E7 -0.32 -0.2669 -0.8299 1734152 Maybridge4_002529 CC(C)(C)OC(=O)N1CCN(CCNC(=O)c2ccc(Cl)cc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C22 compound treatment 1.55846302E8 1570000.0 0.02 1.53002676E8 -1.13E7 -0.19 -0.1232 -0.6319 1710452 Maybridge4_002530 COc1ccc(NC(=O)Nc2ccc(OC)c(OC3CCCC3)c2)cc1OC4CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C23 mock treatment 1.5249446E8 -1780000.0 -0.02 1.52324947E8 -1.2E7 -0.21 -0.1611 -0.7793 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 C24 mock treatment 1.56529475E8 2260000.0 0.03 1.62758191E8 -1580000.0 -0.03 9.0E-4 0.0239 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D01 compound treatment 1.52276351E8 -2000000.0 -0.03 1.59514243E8 -4820000.0 -0.08 -0.0761 -0.882 3064376 Maybridge4_002531 Cc1ccccc1NC(=O)N(Cc2cccs2)C(=O)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D02 compound treatment 1.63212408E8 8940000.0 0.11 1.74886205E8 1.06E7 0.18 0.207 0.9737 3178862 Maybridge4_002532 Cc1nc2ccc(NS(=O)(=O)c3ccccc3C(F)(F)F)cc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D03 compound treatment 1.74801583E8 2.05E7 0.26 1.75797947E8 1.15E7 0.2 0.3209 0.991 3064377 Maybridge4_002533 FC(F)(F)c1cccc(NC(=S)Nc2cc(n[nH]2)c3cccs3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D04 compound treatment 1.48574294E8 -5700000.0 -0.07 1.088885E8 -5.54E7 -0.95 -0.7217 -0.7582 3178863 Maybridge4_002534 Cc1nc(cs1)c2sc3ccc(Cl)cc3c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D05 compound treatment 1.64698123E8 1.04E7 0.13 1.66589247E8 2250000.0 0.04 0.1198 0.8784 1387292 Maybridge4_002535 CCCOc1cc(ccc1OC)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D06 compound treatment 1.53893363E8 -380000.0 0.0 1.60098038E8 -4240000.0 -0.07 -0.0546 -0.7519 3064378 Maybridge4_002536 Cc1c(sc2ccccc12)c3ccnn3C(=O)c4ccc(cc4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D07 compound treatment 1.62387125E8 8110000.0 0.1 1.71747293E8 7410000.0 0.13 0.1617 0.994 1130276 Maybridge4_002537 CSc1ccccc1CNC(=O)NC2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D08 compound treatment 1.49684566E8 -4590000.0 -0.06 1.6009729E8 -4240000.0 -0.07 -0.092 -0.9934 3064379 Maybridge4_002538 FC(F)(F)c1ccc(CSc2nccc(n2)c3cccnc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D09 compound treatment 1.79984366E8 2.57E7 0.32 1.78339302E8 1.4E7 0.24 0.3976 0.9893 3178864 Maybridge4_002539 CCOC(=O)CSc1nnc(c2ccc3ncccc3c2)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D10 compound treatment 1.61922416E8 7650000.0 0.1 1.65733753E8 1400000.0 0.02 0.0848 0.8573 3178865 Maybridge4_002540 Cc1c(sc2ccccc12)C(=S)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D11 compound treatment 1.67383874E8 1.31E7 0.16 1.73327241E8 8990000.0 0.15 0.2251 0.9995 3064380 Maybridge4_002541 CC(C)n1c(nc2cc(ccc12)C(=O)N3CCOCC3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D12 compound treatment 1.64118675E8 9850000.0 0.12 1.64928768E8 594000.0 0.01 0.0945 0.7628 1150832 Maybridge4_002542 Nc1nccc(n1)c2ccc(NC(=O)Nc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D13 compound treatment 1.66582656E8 1.23E7 0.15 1.65742639E8 1410000.0 0.02 0.1262 0.8077 3064381 Maybridge4_002543 CCc1ccc2[nH]c(cc2c1)C(=O)Nc3ccc(c(C#N)c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D14 compound treatment 1.6846103E8 1.42E7 0.18 1.71437311E8 7100000.0 0.12 0.2118 0.9827 3178947 Maybridge4_002544 FC(F)(F)COc1ccc(SCc2ccccc2)c(OCC(F)(F)F)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D15 compound treatment 1.72456529E8 1.82E7 0.23 1.75540942E8 1.12E7 0.19 0.2969 0.9963 1264919 Maybridge4_002545 CC(C)(C)c1ccc(s1)C(=O)OCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D16 compound treatment 1.55753526E8 1480000.0 0.02 1.66638383E8 2300000.0 0.04 0.041 0.941 3064382 Maybridge4_002546 CN1CCC(=N1)/C=C/c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D17 compound treatment 1.60685277E8 6410000.0 0.08 1.55959077E8 -8380000.0 -0.14 -0.0445 -0.2707 3178948 Maybridge4_002547 O=C(NC(=S)N1CCCCC1)/C=C/c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D18 compound treatment 1.6000419E8 5730000.0 0.07 1.62583132E8 -1750000.0 -0.03 0.0296 0.3805 3064383 Maybridge4_002548 Cn1nc(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D19 compound treatment 1.71374404E8 1.71E7 0.21 1.56874432E8 -7460000.0 -0.13 0.0614 0.2459 1464348 Maybridge4_002549 COc1ccc(cc1)C(=O)CSC2=NCCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D20 compound treatment 1.66882282E8 1.26E7 0.16 1.70994173E8 6660000.0 0.11 0.1925 0.9871 3064384 Maybridge4_002550 CC(C)(C)C(=O)NC(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D21 compound treatment 1.56332408E8 2060000.0 0.03 1.6386584E8 -469000.0 -0.01 0.0126 0.4657 3178949 Maybridge4_002551 O=C(Cc1cccc(Oc2ccccc2)c1)c3cccc(C#N)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D22 compound treatment 1.63389547E8 9120000.0 0.11 1.71555886E8 7220000.0 0.12 0.1683 0.9992 3064385 Maybridge4_002552 CC1CCCC(C)N1c2nn(C)c(=O)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D23 mock treatment 1.59107032E8 4830000.0 0.06 1.55854634E8 -8480000.0 -0.15 -0.0598 -0.3799 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 D24 mock treatment 1.46616162E8 -7660000.0 -0.1 1.5654146E8 -7790000.0 -0.13 -0.1622 -0.987 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E01 compound treatment 1.3963278E8 -1.46E7 -0.18 1.18718411E8 -4.56E7 -0.78 -0.682 -0.8502 3064421 Maybridge4_002553 Cn1c(SCc2ccc(F)cc2)nnc1C3COc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E02 compound treatment 1.4824581E8 -6030000.0 -0.08 1.35236173E8 -2.91E7 -0.5 -0.4057 -0.8052 3064422 Maybridge4_002554 CCOC(=O)c1cncc(C#CCOC(=O)Nc2ccc(OC(F)(F)F)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E03 compound treatment 1.60751743E8 6480000.0 0.08 1.35270016E8 -2.91E7 -0.5 -0.2943 -0.5839 1569623 Maybridge4_002555 Clc1ccc(NC(=O)NCC2COc3ccccc3O2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E04 compound treatment 1.02899363E8 -5.14E7 -0.64 1.34500248E8 -2.98E7 -0.51 -0.8168 -0.9934 3064423 Maybridge4_002556 C/S(=N\S(=O)(=O)c1cccc2nsnc12)/c3ncc(Cl)cc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E05 compound treatment 1.63744639E8 9470000.0 0.12 1.36753653E8 -2.76E7 -0.47 -0.2498 -0.5132 1912560 Maybridge4_002557 CNC(=O)N(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E06 compound treatment 1.58089287E8 3820000.0 0.05 1.41853878E8 -2.25E7 -0.38 -0.2383 -0.6144 1719037 Maybridge4_002558 Clc1ccc(cc1)C(=O)OCc2sccc2Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E07 compound treatment 1.50811462E8 -3460000.0 -0.04 1.37945729E8 -2.64E7 -0.45 -0.3501 -0.7715 3064424 Maybridge4_002559 Clc1ccc(SC(=O)c2csc(n2)c3ccc4nonc4c3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E08 compound treatment 1.6672697E8 1.25E7 0.16 1.33968098E8 -3.04E7 -0.52 -0.2571 -0.4737 1379034 Maybridge4_002560 Cc1ccc(SC(=O)c2ccc(C#Cc3ccccc3)o2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E09 compound treatment 1.6311833E8 8850000.0 0.11 1.5363643E8 -1.07E7 -0.18 -0.051 -0.2383 3178950 Maybridge4_002561 O=C1CC2Sc3ccccc3N=C2N1Cc4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E10 compound treatment 1.62866935E8 8590000.0 0.11 1.43707431E8 -2.06E7 -0.35 -0.1734 -0.4698 3064426 Maybridge4_002562 CCOC(=O)c1c(Oc2ccc(OC)cc2)c3cccc(c3nc1SC)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E11 compound treatment 1.66363192E8 1.21E7 0.15 1.47170277E8 -1.72E7 -0.29 -0.1005 -0.304 3178951 Maybridge4_002563 Cn1cc(/C(=N/O)/N)c(=O)n(Cc2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E12 compound treatment 1.49773933E8 -4500000.0 -0.06 1.22483575E8 -4.19E7 -0.72 -0.5465 -0.7605 3178952 Maybridge4_002564 COC(=O)C(Cc1csc2ccc(Cl)cc12)NC(=O)c3ccc(cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E13 compound treatment 1.4809983E8 -6170000.0 -0.08 1.19702326E8 -4.46E7 -0.76 -0.595 -0.7748 1645379 Maybridge4_002565 CC(C)n1cc(c2nc(C)cs2)c(=O)n(Cc3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E14 compound treatment 1.54412072E8 139000.0 0.0 1.1084894E8 -5.35E7 -0.92 -0.6462 -0.7058 3064427 Maybridge4_002566 O=C(OCC#Cc1ccc(C#N)cc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E15 compound treatment 1.7528957E8 2.1E7 0.26 1.41554737E8 -2.28E7 -0.39 -0.0893 -0.1897 3178953 Maybridge4_002567 COC(=O)c1scc2c(Oc3ccccc3C(F)(F)F)cc(nc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E16 compound treatment 1.75318138E8 2.1E7 0.26 1.36127058E8 -2.82E7 -0.48 -0.1548 -0.2812 3178954 Maybridge4_002568 CC(C)(C)c1cc2nc(cc(N3CCN(CC3)c4ccc(cn4)C(F)(F)F)n2n1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E17 compound treatment 1.21874614E8 -3.24E7 -0.41 1.11303527E8 -5.3E7 -0.91 -0.9293 -0.9343 3064428 Maybridge4_002569 Cc1ccc(SCc2nccn2Cc3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E18 compound treatment 1.58968605E8 4700000.0 0.06 1.27666962E8 -3.67E7 -0.63 -0.4022 -0.6379 3178955 Maybridge4_002570 Cn1c(Cc2nc(no2)c3cnccn3)nnc1SCc4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E19 compound treatment 1.41304125E8 -1.3E7 -0.16 1.26544076E8 -3.78E7 -0.65 -0.5725 -0.8582 1530658 Maybridge4_002571 Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)N=S(=O)(C)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E20 compound treatment 1.61120097E8 6850000.0 0.09 1.2509202E8 -3.92E7 -0.67 -0.4143 -0.6117 1174825 Maybridge4_002572 Cn1c(S)nnc1CCN(Cc2ccco2)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E21 compound treatment 1.16220885E8 -3.81E7 -0.48 1.48241442E8 -1.61E7 -0.28 -0.5323 -0.9659 1683285 Maybridge4_002573 COc1ccc(cc1)C(=O)CSC2=NCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E22 compound treatment 1.51274864E8 -3000000.0 -0.04 1.38396965E8 -2.59E7 -0.44 -0.3405 -0.7643 1586313 Maybridge4_002574 COc1ccc(NC(=O)Nc2cc(F)cc(F)c2)cc1OC3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E23 mock treatment 1.42216401E8 -1.21E7 -0.15 1.48546953E8 -1.58E7 -0.27 -0.298 -0.9624 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 E24 mock treatment 1.36617765E8 -1.77E7 -0.22 1.28394878E8 -3.59E7 -0.62 -0.5916 -0.9048 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F01 compound treatment 1.31158855E8 -2.31E7 -0.29 1.31445626E8 -3.29E7 -0.56 -0.6031 -0.9524 1006297 Maybridge4_002575 Clc1ccc(CCc2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F02 compound treatment 1.33155623E8 -2.11E7 -0.26 1.33506569E8 -3.08E7 -0.53 -0.5605 -0.9492 3178956 Maybridge4_002576 Clc1ccccc1C(=O)NC(=O)Nc2ccc3C=CS(=O)(=O)c3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F03 compound treatment 1.51524148E8 -2750000.0 -0.03 9.680876E7 -6.75E7 -1.16 -0.8417 -0.7279 1320469 Maybridge4_002577 O=C(Cc1ccc(CC(=O)c2ccccc2)cc1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F04 compound treatment 1.4343828E8 -1.08E7 -0.14 1.38665877E8 -2.57E7 -0.44 -0.4068 -0.8845 1267104 Maybridge4_002578 Cc1c(CC(=O)Nc2ccc(Cl)cc2)sc3ccc(Cl)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F05 compound treatment 1.54194946E8 -78300.0 0.0 1.02655727E8 -6.17E7 -1.06 -0.7473 -0.7078 3064429 Maybridge4_002579 CCCn1c(=O)ccn(c2ccccc2C)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F06 compound treatment 1.3407541E8 -2.02E7 -0.25 1.54184268E8 -1.02E7 -0.17 -0.302 -0.9831 1449737 Maybridge4_002580 O=C(CSC1=NCCc2ccccc12)c3ccc(cc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F07 compound treatment 1.3057609E8 -2.37E7 -0.3 1.18995287E8 -4.53E7 -0.78 -0.759 -0.9132 3064430 Maybridge4_002581 O=C(CNC(=O)OCc1ccccc1)ON2C(=O)CCC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F08 compound treatment 1.37636969E8 -1.66E7 -0.21 1.46218778E8 -1.81E7 -0.31 -0.3668 -0.9814 1291828 Maybridge4_002582 Cc1c(sc2ccc(Cl)cc12)c3cc(NC(=O)c4ccccc4)[nH]n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F09 compound treatment 1.59260839E8 4990000.0 0.06 1.41439984E8 -2.29E7 -0.39 -0.2329 -0.5868 3064431 Maybridge4_002583 CC(=O)OC1CCN(CC1)c2cc(nc3cc(Cl)cc(Cl)c23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F10 compound treatment 1.22385133E8 -3.19E7 -0.4 1.36519956E8 -2.78E7 -0.48 -0.6195 -0.9962 3178957 Maybridge4_002584 CNC(=S)c1sc2ccccc2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F11 compound treatment 1.44160273E8 -1.01E7 -0.13 1.44584888E8 -1.97E7 -0.34 -0.3288 -0.9105 1269577 Maybridge4_002585 O=C(NCc1ccc(s1)S(=O)(=O)NCc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F12 compound treatment 1.44633708E8 -9640000.0 -0.12 1.44433357E8 -1.99E7 -0.34 -0.3264 -0.9029 3064432 Maybridge4_002586 FC(F)(F)COc1ccc(c(OCC(F)(F)F)c1C#N)S(=O)(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F13 compound treatment 1.44732034E8 -9540000.0 -0.12 1.42774422E8 -2.16E7 -0.37 -0.3456 -0.8908 1508849 Maybridge4_002587 CCC(C)c1ccccc1NC(=O)c2cc3cc(CC)ccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F14 compound treatment 1.40512729E8 -1.38E7 -0.17 1.36600557E8 -2.77E7 -0.47 -0.4578 -0.9062 3064434 Maybridge4_002588 FC(F)(F)COc1ccc(SCC=C)c(OCC(F)(F)F)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F15 compound treatment 1.46207132E8 -8070000.0 -0.1 1.58268355E8 -6070000.0 -0.1 -0.145 -0.9999 1212532 Maybridge4_002589 Cc1cccc(NC(=O)NC(=O)c2ccc(s2)C(C)(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F16 compound treatment 1.38784314E8 -1.55E7 -0.19 1.44766499E8 -1.96E7 -0.33 -0.3742 -0.9665 3064435 Maybridge4_002590 C(N1CCC(=N1)/C=C/c2ccco2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F17 compound treatment 1.59123037E8 4850000.0 0.06 1.49891006E8 -1.44E7 -0.25 -0.1318 -0.5177 1289651 Maybridge4_002591 CC(C)N(C(C)C)C(=O)NC(=O)c1ccc(F)cc1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F18 compound treatment 1.51742272E8 -2530000.0 -0.03 1.46728232E8 -1.76E7 -0.3 -0.2356 -0.7773 3064458 Maybridge4_002592 NN/C(=N\S(=O)(=O)c1ccccc1)/Nc2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F19 compound treatment 1.3898559E8 -1.53E7 -0.19 1.45558222E8 -1.88E7 -0.32 -0.3629 -0.9695 3064459 Maybridge4_002593 FC(F)(F)c1cccc(c1)n2c(n[nH]c2=S)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F20 compound treatment 1.62788806E8 8520000.0 0.11 1.51732387E8 -1.26E7 -0.22 -0.077 -0.3199 3064460 Maybridge4_002594 NNC(=S)c1cc(Cl)cc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F21 compound treatment 1.38337481E8 -1.59E7 -0.2 1.34154691E8 -3.02E7 -0.52 -0.5067 -0.9146 3064461 Maybridge4_002595 NC(=O)c1ccc(CC(=O)c2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F22 compound treatment 1.46637795E8 -7640000.0 -0.1 1.43513144E8 -2.08E7 -0.36 -0.3198 -0.8664 3064462 Maybridge4_002596 C1CN=C(S1)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F23 mock treatment 1.38646605E8 -1.56E7 -0.2 1.45029792E8 -1.93E7 -0.33 -0.3723 -0.9689 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 F24 mock treatment 1.3789808E8 -1.64E7 -0.21 1.24858947E8 -3.95E7 -0.68 -0.6231 -0.8822 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G01 compound treatment 1.40681783E8 -1.36E7 -0.17 1.43075071E8 -2.13E7 -0.36 -0.3779 -0.9403 3064463 Maybridge4_002597 Cn1c(SCC(=O)c2ccccc2)nnc1C3COc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G02 compound treatment 1.29875354E8 -2.44E7 -0.31 1.45095564E8 -1.92E7 -0.33 -0.4493 -0.9993 3064464 Maybridge4_002598 COc1cc(nc2ccc(C)c(NC(=O)c3ccc(Cl)cc3)c12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G03 compound treatment 1.54656722E8 384000.0 0.0 1.63846966E8 -487000.0 -0.01 -0.0025 -0.2593 1291018 Maybridge4_002599 Cc1ccc(NC(=S)NCC2COc3ccccc3O2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G04 compound treatment 1.48661399E8 -5610000.0 -0.07 1.56205898E8 -8130000.0 -0.14 -0.1482 -0.9502 3064465 Maybridge4_002600 Cc1c(noc1C(=O)CN=S(=O)(C)c2ccc(cn2)C(F)(F)F)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G05 compound treatment 1.68532354E8 1.43E7 0.18 1.82027052E8 1.77E7 0.3 0.3406 0.9684 3178958 Maybridge4_002601 COc1cccn(Cc2nnc(S)n2C)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G06 compound treatment 1.66266597E8 1.2E7 0.15 1.81725475E8 1.74E7 0.3 0.3169 0.95 1395477 Maybridge4_002602 Clc1ccccc1C(=O)N2CCC(CC2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G07 compound treatment 1.5411656E8 -157000.0 0.0 1.73035859E8 8700000.0 0.15 0.1039 0.6977 3064466 Maybridge4_002603 Clc1ccc(cc1)C(=O)CSc2nc3CSCc3c(=O)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G08 compound treatment 1.71798547E8 1.75E7 0.22 1.90554865E8 2.62E7 0.45 0.4728 0.9461 1133834 Maybridge4_002604 O=c1[nH]c(=O)n(nc1C#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G09 compound treatment 1.69417338E8 1.51E7 0.19 1.73299111E8 8960000.0 0.15 0.2428 0.9944 3064468 Maybridge4_002605 CCOC(=O)c1nnc2c(Br)c(C)nn2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G10 compound treatment 1.64757633E8 1.05E7 0.13 1.79327552E8 1.5E7 0.26 0.2745 0.9518 3178959 Maybridge4_002606 CSc1nn(cc1C(=O)Nc2cccc(c2)C(F)(F)F)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G11 compound treatment 1.53376686E8 -897000.0 -0.01 1.71188377E8 6850000.0 0.12 0.075 0.6364 1533729 Maybridge4_002607 CC(C)n1cc(c2noc(n2)c3ccccc3Cl)c(=O)n(Cc4ccccc4)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G12 compound treatment 1.59293315E8 5020000.0 0.06 1.9390108E8 2.96E7 0.51 0.4024 0.789 1333749 Maybridge4_002608 CSc1nc2c(Cl)cccc2c3n(C)n(Cc4ccc(Cl)cc4)c(=O)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G13 compound treatment 1.58107569E8 3830000.0 0.05 1.70086398E8 5750000.0 0.1 0.1036 0.9457 1217547 Maybridge4_002609 CC(C)n1cc(c2nc(cs2)C(C)(C)C)c(=O)n(Cc3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G14 compound treatment 1.66712504E8 1.24E7 0.16 1.65960508E8 1630000.0 0.03 0.13 0.8203 1707847 Maybridge4_002610 CCCn1c(=O)cc(N)n(c2ccc(Cl)cc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G15 compound treatment 1.56066499E8 1790000.0 0.02 1.05543024E8 -5.88E7 -1.01 -0.6957 -0.6911 1123385 Maybridge4_002611 CCOC(=O)c1cn(Cc2cccc(Cl)c2)c3cc(C)nn3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G16 compound treatment 1.63333371E8 9060000.0 0.11 1.73423834E8 9090000.0 0.16 0.1904 0.9881 3064470 Maybridge4_002612 CCCn1c(=O)cc(N)n(c2ccc(OC(F)(F)F)cc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G17 compound treatment 1.63851794E8 9580000.0 0.12 1.77970316E8 1.36E7 0.23 0.25 0.9523 3178960 Maybridge4_002613 CC(C)(C)c1cc2nc(cc(Sc3ccccc3)n2n1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G18 compound treatment 1.60510617E8 6240000.0 0.08 2.08348181E8 4.4E7 0.75 0.5881 0.7764 3064471 Maybridge4_002614 Cn1c(Cc2nc(no2)c3cnccn3)nnc1SCC(=O)Nc4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G19 compound treatment 1.57094969E8 2820000.0 0.04 1.68825319E8 4490000.0 0.08 0.0794 0.938 1167659 Maybridge4_002615 Cn1c(=O)c(cn(c2ccccc2)c1=O)c3noc(n3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G20 compound treatment 1.5283826E8 -1430000.0 -0.02 1.01454537E8 -6.29E7 -1.08 -0.7738 -0.7188 1420377 Maybridge4_002616 Clc1ccc(NC(=O)CCN(Cc2ccco2)S(=O)(=O)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G21 compound treatment 1.53163149E8 -1110000.0 -0.01 1.73422394E8 9090000.0 0.16 0.1002 0.6412 3064472 Maybridge4_002617 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G22 compound treatment 1.41175949E8 -1.31E7 -0.16 1.6314859E8 -1190000.0 -0.02 -0.1305 -0.7885 1413855 Maybridge4_002618 O=C(N1CCN(CC1)C(c2ccccc2)c3ccccc3)c4ccc5nonc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G23 mock treatment 1.62493031E8 8220000.0 0.1 1.84911817E8 2.06E7 0.35 0.322 0.8773 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 G24 mock treatment 1.54956006E8 683000.0 0.01 1.87053442E8 2.27E7 0.39 0.2811 0.7225 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H01 compound treatment 1.59698344E8 5430000.0 0.07 1.71778092E8 7440000.0 0.13 0.1382 0.9568 3064474 Maybridge4_002619 Cc1ccccc1NC(=O)NC(=O)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H02 compound treatment 1.61328034E8 7050000.0 0.09 1.74207247E8 9870000.0 0.17 0.1821 0.9544 1680806 Maybridge4_002620 OC(=O)Cc1csc2ccc(Cl)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H03 compound treatment 1.5643037E8 2160000.0 0.03 1.93710358E8 2.94E7 0.5 0.3747 0.7441 3064475 Maybridge4_002621 COc1ccccc1CCn2cc(C#N)c(=O)[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H04 compound treatment 1.69936968E8 1.57E7 0.2 1.83923172E8 1.96E7 0.34 0.376 0.9676 3179054 Maybridge4_002622 Cc1cccc(NC(=S)N2CCOC2c3ccsc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H05 compound treatment 1.55212666E8 939000.0 0.01 1.75367961E8 1.1E7 0.19 0.1419 0.7498 1623471 Maybridge4_002623 CCCn1c(=O)c(C#N)cn(C2CC2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H06 compound treatment 1.31167705E8 -2.31E7 -0.29 1.43942439E8 -2.04E7 -0.35 -0.4518 -0.9957 3179055 Maybridge4_002624 Cc1c(sc2ccc(Cl)cc12)c3ccnn3S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H07 compound treatment 1.57670321E8 3400000.0 0.04 1.80557902E8 1.62E7 0.28 0.2265 0.8062 3179056 Maybridge4_002625 COc1ccc(Cn2c(=O)n(c3cc(ccc3C)S(=O)C)c4nc[nH]c4c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H08 compound treatment 1.58901974E8 4630000.0 0.06 1.78992466E8 1.47E7 0.25 0.2185 0.8483 3064477 Maybridge4_002626 CC(C)c1ccc(/N=C/c2sc3ccccc3c2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H09 compound treatment 1.50022565E8 -4250000.0 -0.05 1.7898867E8 1.47E7 0.25 0.1397 0.5446 3179057 Maybridge4_002627 CCOC(=O)c1ccc2nc(cc(N3CCN(CC3)c4ccccc4)c2c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H10 compound treatment 1.62387942E8 8110000.0 0.1 1.82144708E8 1.78E7 0.3 0.2876 0.8947 3064478 Maybridge4_002628 Cc1c(/C=N/O)sc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H11 compound treatment 1.66873934E8 1.26E7 0.16 1.82081353E8 1.77E7 0.3 0.3266 0.9537 3064510 Maybridge4_002629 COc1ccc(cc1)c2ccnc(SCc3ccc(Cl)cc3Cl)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H12 compound treatment 1.55323887E8 1050000.0 0.01 1.8275453E8 1.84E7 0.32 0.2323 0.736 1135828 Maybridge4_002630 OC(=O)CC(NC(=O)Nc1ccccc1)c2ccsc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H13 compound treatment 1.39808995E8 -1.45E7 -0.18 1.60450036E8 -3880000.0 -0.07 -0.1753 -0.9072 1625372 Maybridge4_002631 Clc1ccc2c(ccnc2c1)N3CCN(CC3)C(=O)C4CCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H14 compound treatment 1.54687613E8 414000.0 0.01 1.65980446E8 1650000.0 0.03 0.0236 0.8237 3064512 Maybridge4_002632 COc1ccc(NS(=O)(=O)c2ccc(OCC(F)(F)F)c(C#N)c2OCC(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H15 compound treatment 1.51936681E8 -2340000.0 -0.03 1.88700562E8 2.44E7 0.42 0.2742 0.6558 3064513 Maybridge4_002633 CCOC(=O)c1sc(Nc2ccccc2C(F)(F)F)c(C(=O)OCC)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H16 compound treatment 1.50202937E8 -4070000.0 -0.05 1.80491805E8 1.62E7 0.28 0.1595 0.567 3064514 Maybridge4_002634 Clc1cccc(N/C(=N\S(=O)(=O)c2ccccc2)/NCCc3ccccn3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H17 compound treatment 1.66388742E8 1.21E7 0.15 1.86454381E8 2.21E7 0.38 0.3752 0.9196 3064515 Maybridge4_002635 CCOC(=O)NC(=S)Nc1cccc(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H18 compound treatment 1.64699298E8 1.04E7 0.13 1.95540258E8 3.12E7 0.53 0.4702 0.855 3179058 Maybridge4_002636 CCOC(=O)NC(=S)N1CCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H19 compound treatment 1.51982683E8 -2290000.0 -0.03 1.94322898E8 3.0E7 0.51 0.3427 0.6665 3179059 Maybridge4_002637 COc1ccc(CSC2=NCN(CN2)C3CC(C)CC(C)(C)C3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H20 compound treatment 1.69877538E8 1.56E7 0.2 1.89553286E8 2.52E7 0.43 0.4437 0.936 1226235 Maybridge4_002638 S=C(NCc1ccccc1)NCc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H21 compound treatment 1.69699629E8 1.54E7 0.19 1.98791272E8 3.45E7 0.59 0.5539 0.8923 3179060 Maybridge4_002639 O=C(Cc1ccc(Oc2ccccc2)cc1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H22 compound treatment 1.58401088E8 4130000.0 0.05 1.85056585E8 2.07E7 0.35 0.2874 0.8018 3064516 Maybridge4_002640 CCOC(=S)Nc1cccc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H23 mock treatment 1.60370475E8 6100000.0 0.08 1.88817175E8 2.45E7 0.42 0.3504 0.8226 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 H24 mock treatment 1.55813744E8 1540000.0 0.02 1.81100763E8 1.68E7 0.29 0.2166 0.753 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I01 compound treatment 1.64615527E8 1.03E7 0.13 2.03817485E8 3.95E7 0.68 0.5697 0.8277 1349293 Maybridge4_002641 COC(=O)c1ccc-2c(c1)N(C)S(=O)(=O)c3cnc(SC)nc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I02 compound treatment 1.9299183E8 3.87E7 0.49 2.17530287E8 5.32E7 0.91 0.9873 0.9567 3064517 Maybridge4_002642 NNC(=O)c1cncc(C#Cc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I03 compound treatment 1.82376691E8 2.81E7 0.35 2.11158641E8 4.68E7 0.8 0.8161 0.932 1297264 Maybridge4_002643 Clc1ccc(cc1)C(=O)NC(=S)NCC2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I04 compound treatment 2.04569209E8 5.03E7 0.63 2.30948632E8 6.66E7 1.14 1.2525 0.9611 1443440 Maybridge4_002644 COC(=O)c1csc(c1OC)S(=O)(=O)N=S(=O)(C)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I05 compound treatment 1.92652168E8 3.84E7 0.48 2.33446958E8 6.91E7 1.18 1.177 0.9215 3179061 Maybridge4_002645 COc1ccc2nc([nH]c2c1)S(=O)Cc3ncc(C)c(OC)c3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I06 compound treatment 2.12044044E8 5.78E7 0.72 2.42686182E8 7.84E7 1.34 1.4608 0.9582 1207614 Maybridge4_002646 Clc1ccc(cc1)S(=O)(=O)N2CCC(CC2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I07 compound treatment 2.281396E8 7.39E7 0.93 2.32671378E8 6.83E7 1.17 1.4824 0.9933 1176328 Maybridge4_002647 Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCC(=O)c4ccc(Cl)cc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I08 compound treatment 2.1339646E8 5.91E7 0.74 2.31145575E8 6.68E7 1.14 1.3331 0.978 1698489 Maybridge4_002648 Clc1ccc(Cn2c(=O)c(C#N)nn(c3ccccc3)c2=O)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I09 compound treatment 2.19891571E8 6.56E7 0.82 2.48843385E8 8.45E7 1.45 1.605 0.9643 1223405 Maybridge4_002649 CCOC(=O)NC(=O)c1cn(CCc2ccncc2)c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I10 compound treatment 2.23111116E8 6.88E7 0.86 2.45646265E8 8.13E7 1.39 1.5948 0.9736 1257420 Maybridge4_002650 CSc1nn(cc1C(=O)N2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I11 compound treatment 2.2001278E8 6.57E7 0.82 2.44972379E8 8.06E7 1.38 1.5592 0.9697 3064519 Maybridge4_002651 CC(C)n1cc(/C(=N/O)/N)c(=O)n(Cc2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I12 compound treatment 2.20684361E8 6.64E7 0.83 2.57077897E8 9.27E7 1.59 1.7117 0.9547 1544891 Maybridge4_002652 OC(=O)C1CNC(=O)N1C(=O)OCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I13 compound treatment 1.78111394E8 2.38E7 0.3 1.94085421E8 2.98E7 0.51 0.5716 0.9678 1689579 Maybridge4_002653 CCOC(=O)c1csc(n1)c2cn(C(C)C)c(=O)n(Cc3ccccc3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I14 compound treatment 2.10500169E8 5.62E7 0.71 2.13143659E8 4.88E7 0.84 1.0895 0.9965 3064520 Maybridge4_002654 Cn1c(CSCC(=O)Nc2ccccc2)nnc1SCc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I15 compound treatment 1.9585487E8 4.16E7 0.52 1.99052316E8 3.47E7 0.59 0.7891 0.9979 3179062 Maybridge4_002655 Cc1[nH]c2ccccc2c1SCc3nnc(SCc4ccc(Cl)cc4)n3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I16 compound treatment 1.86136835E8 3.19E7 0.4 2.04649183E8 4.03E7 0.69 0.7706 0.9663 3064521 Maybridge4_002656 Cn1c(CSCC(=O)Nc2ccccc2)nnc1SCC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I17 compound treatment 2.0786016E8 5.36E7 0.67 2.1429298E8 5.0E7 0.86 1.08 0.9929 3179063 Maybridge4_002657 COc1ccc(Oc2cc(nc3cc(nn23)C(C)(C)C)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I18 compound treatment 2.32826404E8 7.86E7 0.99 2.65720323E8 1.01E8 1.74 1.924 0.964 3179064 Maybridge4_002658 CSc1cccc(NC(=O)N(Cc2ccccc2)C(=O)CC#N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I19 compound treatment 2.23963657E8 6.97E7 0.87 2.30833155E8 6.65E7 1.14 1.4231 0.9915 1399847 Maybridge4_002659 O=S1(=O)CC(N2CCCC2)c3ccccc31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I20 compound treatment 2.30551677E8 7.63E7 0.96 2.5941881E8 9.51E7 1.63 1.8275 0.9679 3179065 Maybridge4_002660 FC(F)(F)c1cc(N2CCC(CC2)n3cccc3)c4ccccc4n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I21 compound treatment 2.4333926E8 8.91E7 1.12 2.381218E8 7.38E7 1.26 1.6832 0.9981 3064522 Maybridge4_002661 O=C(OCc1ccc(C#Cc2ccccc2)s1)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I22 compound treatment 2.22383207E8 6.81E7 0.85 2.53253039E8 8.89E7 1.52 1.6804 0.9627 1065782 Maybridge4_002662 O=C(NCc1ccccc1)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I23 mock treatment 2.18830558E8 6.46E7 0.81 2.37584417E8 7.33E7 1.25 1.4593 0.9776 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 I24 mock treatment 2.1993827E8 6.57E7 0.82 2.61646027E8 9.73E7 1.67 1.7604 0.9473 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J01 compound treatment 2.06477161E8 5.22E7 0.65 2.27665909E8 6.33E7 1.08 1.2296 0.9709 3064524 Maybridge4_002663 Cn1c(SCc2cc(F)cc(F)c2)nnc1c3ccc4nonc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J02 compound treatment 2.30864743E8 7.66E7 0.96 2.4739823E8 8.31E7 1.42 1.6848 0.9818 3179066 Maybridge4_002664 Clc1ccc2scc(CC(=O)OCc3ccccc3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J03 compound treatment 2.27099462E8 7.28E7 0.91 2.43009101E8 7.87E7 1.35 1.5983 0.9821 3064525 Maybridge4_002665 FC(F)(F)c1cc(N2CCCCC2)c3cccc(Cl)c3n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J04 compound treatment 2.09479013E8 5.52E7 0.69 2.53256833E8 8.89E7 1.52 1.566 0.9365 3179067 Maybridge4_002666 NC(=S)Cc1c(Cl)sc2ccc(Cl)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J05 compound treatment 2.24017247E8 6.97E7 0.87 2.52061681E8 8.77E7 1.5 1.6805 0.9669 1230774 Maybridge4_002667 O=c1c(C#N)cn(C2CC2)c(=O)n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J06 compound treatment 2.37446377E8 8.32E7 1.04 2.46224566E8 8.19E7 1.4 1.729 0.9894 3064526 Maybridge4_002668 Cc1c(sc2ccc(Cl)cc12)c3ccnc(SCC=C)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J07 compound treatment 2.39192365E8 8.49E7 1.07 2.45782886E8 8.14E7 1.39 1.7391 0.9912 1249532 Maybridge4_002669 Cc1cc(NC(=O)c2ccc3nonc3c2)on1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J08 compound treatment 2.25773904E8 7.15E7 0.9 2.6710571E8 1.03E8 1.76 1.8782 0.9511 1640712 Maybridge4_002670 CN1C(=O)CC(Sc2ccccc12)c3ccsc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J09 compound treatment 2.35182612E8 8.09E7 1.01 2.60626521E8 9.63E7 1.65 1.8832 0.9729 3064554 Maybridge4_002671 Cc1ccc2c(cc(nc2c1)C(F)(F)F)N3CC4CCC(CC4)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J10 compound treatment 2.32679488E8 7.84E7 0.98 2.64138825E8 9.98E7 1.71 1.9035 0.9656 3064555 Maybridge4_002672 Fc1ccc(NC2=NNC(=O)C2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J11 compound treatment 2.25273538E8 7.1E7 0.89 2.60146668E8 9.58E7 1.64 1.7895 0.9588 3064556 Maybridge4_002673 COc1ccc(cc1)c2ccnc(SCC(=O)N3CCOCC3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J12 compound treatment 2.08600495E8 5.43E7 0.68 2.59433615E8 9.51E7 1.63 1.633 0.9253 1655959 Maybridge4_002674 CCCS(=O)(=O)c1ccc(NC(=O)Nc2ccc(Cl)cc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J13 compound treatment 1.88858156E8 3.46E7 0.43 2.06582685E8 4.22E7 0.72 0.8182 0.9701 1535225 Maybridge4_002675 CC(C)N(C(C)C)C(=O)N1CCN(CC1)c2ccnc3cc(Cl)ccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J14 compound treatment 2.34528314E8 8.03E7 1.01 2.64717934E8 1.0E8 1.72 1.927 0.9676 3064558 Maybridge4_002676 FC(F)(F)COc1ccc(Br)c(OCC(F)(F)F)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J15 compound treatment 1.76348533E8 2.21E7 0.28 1.82535292E8 1.82E7 0.31 0.4161 0.9983 3064559 Maybridge4_002677 COC(=O)c1ccccc1SC(=O)c2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J16 compound treatment 2.15188585E8 6.09E7 0.76 2.31157399E8 6.68E7 1.14 1.3492 0.9808 1497304 Maybridge4_002678 Clc1ccc(NC(=S)NS(=O)(=O)c2ccccc2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J17 compound treatment 2.14614655E8 6.03E7 0.76 2.21965763E8 5.76E7 0.99 1.2328 0.9914 1102994 Maybridge4_002679 CCOC(=O)NC(=S)c1cccn1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J18 compound treatment 2.27651121E8 7.34E7 0.92 2.54812869E8 9.05E7 1.55 1.7461 0.9691 1203607 Maybridge4_002680 COc1ccc(OC)c(c1)S(=O)(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J19 compound treatment 2.53227731E8 9.9E7 1.24 2.38557673E8 7.42E7 1.27 1.7762 0.9999 3064560 Maybridge4_002681 S=C1NCN(Cc2ccncc2)CN1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J20 compound treatment 2.36271192E8 8.2E7 1.03 2.43875041E8 7.95E7 1.36 1.6901 0.9904 3179068 Maybridge4_002682 Cc1cc(Br)c(NC(=S)NC(=O)C(C)(C)C)c(Br)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J21 compound treatment 2.32528767E8 7.83E7 0.98 2.54424537E8 9.01E7 1.54 1.7846 0.9762 3064561 Maybridge4_002683 COC(=O)c1ccc2[nH]cnc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J22 compound treatment 2.19519328E8 6.52E7 0.82 2.36437151E8 7.21E7 1.23 1.4515 0.9801 3179069 Maybridge4_002684 O=c1[nH]nc([nH]1)N2CCSCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J23 mock treatment 2.11499689E8 5.72E7 0.72 2.38132996E8 7.38E7 1.26 1.4009 0.9641 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 J24 mock treatment 2.11399742E8 5.71E7 0.72 2.29964722E8 6.56E7 1.12 1.3011 0.9764 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K01 compound treatment 1.29856919E8 -2.44E7 -0.31 1.24121448E8 -4.02E7 -0.69 -0.7033 -0.9335 3064562 Maybridge4_002685 COC(=O)c1ccc2OCCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K02 compound treatment 1.3667151E8 -1.76E7 -0.22 1.20855772E8 -4.35E7 -0.74 -0.6824 -0.879 3179151 Maybridge4_002686 CCOC(=O)c1cncc(C#CCOC(=O)c2c(C)onc2c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K03 compound treatment 1.358377E8 -1.84E7 -0.23 1.17232723E8 -4.71E7 -0.81 -0.7337 -0.8747 1273322 Maybridge4_002687 CCOC(=O)Cc1nn(Cc2nc(cs2)c3ccccc3)c(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K04 compound treatment 1.47153712E8 -7120000.0 -0.09 1.30113835E8 -3.42E7 -0.59 -0.4774 -0.8056 3179152 Maybridge4_002688 CN(CCOC(=O)c1ccccc1)c2cc(nc3ccccc23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K05 compound treatment 1.73181664E8 1.89E7 0.24 1.43030159E8 -2.13E7 -0.36 -0.0901 -0.2072 3179153 Maybridge4_002689 COc1cccn(Cc2nnc(SCC(=O)c3ccccc3)o2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K06 compound treatment 1.55917203E8 1640000.0 0.02 1.37349446E8 -2.7E7 -0.46 -0.312 -0.6749 1551980 Maybridge4_002690 Clc1cc(Cl)cc(NC(=O)N2CCC(CC2)n3cccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K07 compound treatment 1.72112109E8 1.78E7 0.22 1.57999243E8 -6340000.0 -0.11 0.0816 0.328 3179154 Maybridge4_002691 CN(C)c1cc(nc2cc(nn12)C(C)(C)C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K08 compound treatment 1.61268596E8 7000000.0 0.09 1.45435875E8 -1.89E7 -0.32 -0.1667 -0.4973 3064563 Maybridge4_002692 CCCn1c(=O)c(nn(c2ccccc2)c1=O)/C(=N/O)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K09 compound treatment 2.00704607E8 4.64E7 0.58 1.94685813E8 3.04E7 0.52 0.7792 0.9984 1707363 Maybridge4_002693 Cc1ncn2cc([nH]c(=O)c12)c3ccc(Cl)cc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K10 compound treatment 1.28174662E8 -2.61E7 -0.33 1.22688103E8 -4.16E7 -0.71 -0.7356 -0.9377 3179155 Maybridge4_002694 COC(=O)c1c(C)[nH]c(C)c1/C=C(\C#N)/S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K11 compound treatment 1.60379059E8 6110000.0 0.08 1.62723176E8 -1610000.0 -0.03 0.0347 0.4257 1478501 Maybridge4_002695 CC(C)n1cc(c2noc(n2)c3cccs3)c(=O)n(Cc4ccccc4)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K12 compound treatment 1.64488652E8 1.02E7 0.13 1.76468328E8 1.21E7 0.21 0.2375 0.9731 3179156 Maybridge4_002696 O=S(=O)(c1ccccc1)n2ccc(n2)c3ccc(C#Cc4ccccc4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K13 compound treatment 1.33655335E8 -2.06E7 -0.26 1.26999775E8 -3.73E7 -0.64 -0.6348 -0.9207 1572994 Maybridge4_002697 CC(C)n1cc(c2nc(cs2)C(=O)NN)c(=O)n(Cc3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K14 compound treatment 1.44693449E8 -9580000.0 -0.12 1.51822104E8 -1.25E7 -0.21 -0.2364 -0.9627 1626520 Maybridge4_002698 O=C(CSc1nc2ccccc2o1)N3CCC(CC3)n4cccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K15 compound treatment 1.60256816E8 5980000.0 0.08 1.04179676E8 -6.02E7 -1.03 -0.675 -0.6538 3179157 Maybridge4_002699 COc1cc(nc2ccc(C#CCOC(=O)c3ccccc3)cc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K16 compound treatment 1.53826296E8 -447000.0 -0.01 1.65554805E8 1220000.0 0.02 0.0108 0.4997 3064565 Maybridge4_002700 CCOC(=O)N1CCC(CC1)N/C=C(\C#N)/S(=O)(=O)c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K17 compound treatment 1.55679798E8 1410000.0 0.02 1.56627286E8 -7710000.0 -0.13 -0.0808 -0.6071 3179158 Maybridge4_002701 Cc1ccc(cc1)S(=O)(=O)CCN2CCC(CC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K18 compound treatment 1.48900958E8 -5370000.0 -0.07 1.41683597E8 -2.27E7 -0.39 -0.3218 -0.8177 3064567 Maybridge4_002702 CSc1scc(NC(=O)c2ccc(Cl)cc2)c1S(=O)(=O)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K19 compound treatment 1.48985146E8 -5290000.0 -0.07 1.71691405E8 7360000.0 0.13 0.0421 0.2961 3179159 Maybridge4_002703 O=S(=O)(/C(=C/N1CCN(CC1)C(c2ccccc2)c3ccccc3)/C#N)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K20 compound treatment 1.37585905E8 -1.67E7 -0.21 1.5355995E8 -1.08E7 -0.18 -0.2784 -0.998 3064568 Maybridge4_002704 COC(=O)c1scc2c(cc(nc12)C(F)(F)F)N3CCC(CC3)n4cccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K21 compound treatment 1.49471155E8 -4800000.0 -0.06 1.41731812E8 -2.26E7 -0.39 -0.3162 -0.8075 3179160 Maybridge4_002705 CCOC(=O)C1CCN(CC1)/C=C(\C#N)/S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K22 compound treatment 1.5320469E8 -1070000.0 -0.01 1.44724739E8 -1.96E7 -0.34 -0.2468 -0.7348 1717162 Maybridge4_002706 CCCS(=O)(=O)c1cnc(nc1N)C2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K23 mock treatment 1.5853251E8 4260000.0 0.05 1.49756828E8 -1.46E7 -0.25 -0.1387 -0.5434 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 K24 mock treatment 1.52196273E8 -2080000.0 -0.03 1.53577619E8 -1.08E7 -0.18 -0.1486 -0.7992 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L01 compound treatment 1.36905295E8 -1.74E7 -0.22 1.32883916E8 -3.15E7 -0.54 -0.5347 -0.9207 1068568 Maybridge4_002707 CCOC(=O)c1c(C)oc(=O)c(Br)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L02 compound treatment 1.39754539E8 -1.45E7 -0.18 1.39350014E8 -2.5E7 -0.43 -0.4312 -0.9276 3064569 Maybridge4_002708 Clc1sc2ccc(Cl)cc2c1CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L03 compound treatment 1.29154909E8 -2.51E7 -0.32 1.25961233E8 -3.84E7 -0.66 -0.6873 -0.9434 1726018 Maybridge4_002709 Clc1ccc(cc1)S(=O)(=O)CCN2CCN(CC2)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L04 compound treatment 1.35783395E8 -1.85E7 -0.23 1.30533991E8 -3.38E7 -0.58 -0.5731 -0.9194 3064570 Maybridge4_002710 CCOC(=O)c1csc(Cc2c(Cl)sc3ccc(Cl)cc23)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L05 compound treatment 1.48521591E8 -5750000.0 -0.07 1.3609031E8 -2.82E7 -0.48 -0.3929 -0.8037 3179161 Maybridge4_002711 Fc1ccc(NC(=O)NC(=O)CC#N)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L06 compound treatment 1.32508967E8 -2.18E7 -0.27 1.3272516E8 -3.16E7 -0.54 -0.5757 -0.9498 1493566 Maybridge4_002712 O=C(SC1=NCCc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L07 compound treatment 1.35299683E8 -1.9E7 -0.24 1.40511679E8 -2.38E7 -0.41 -0.4567 -0.9671 3064593 Maybridge4_002713 OC1(CC(=NN1)c2nccs2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L08 compound treatment 1.55681555E8 1410000.0 0.02 1.50098755E8 -1.42E7 -0.24 -0.1598 -0.6541 3064595 Maybridge4_002714 Cc1c(/C=C/C(=O)Oc2ccc(C#N)cc2)sc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L09 compound treatment 1.30607129E8 -2.37E7 -0.3 1.30914039E8 -3.34E7 -0.57 -0.6145 -0.9533 3064596 Maybridge4_002715 CCOC(=O)C1CCN(CC1)c2cc(nc3ccc(C)cc23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L10 compound treatment 1.4914313E8 -5130000.0 -0.06 1.4496564E8 -1.94E7 -0.33 -0.2799 -0.8289 3064597 Maybridge4_002716 CC(C)c1ccc(NC2=NNC(=O)C2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L11 compound treatment 1.47380363E8 -6890000.0 -0.09 1.48171353E8 -1.62E7 -0.28 -0.2568 -0.8858 3482130 Maybridge4_002717 CC(C)(C)OC(=O)Nc1ncnc2n(cnc12)C3OC(CO)C4OC(C)(C)OC34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L12 compound treatment 1.391685E8 -1.51E7 -0.19 1.49011206E8 -1.53E7 -0.26 -0.3195 -0.9873 3064598 Maybridge4_002718 Cc1n[nH]c(C)c1Sc2nccc(n2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L13 compound treatment 1.31034945E8 -2.32E7 -0.29 1.34828745E8 -2.95E7 -0.51 -0.5633 -0.9659 1572567 Maybridge4_002719 O=C(NCc1ccc(s1)S(=O)(=O)NCCN2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L14 compound treatment 1.48532622E8 -5740000.0 -0.07 1.50885509E8 -1.34E7 -0.23 -0.2137 -0.886 3064599 Maybridge4_002720 NC(=O)c1csc(n1)c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L15 compound treatment 1.4486446E8 -9410000.0 -0.12 1.6110845E8 -3230000.0 -0.06 -0.1225 -0.9401 3064600 Maybridge4_002721 Clc1ccc(cc1)c2nnc(o2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L16 compound treatment 1.44533136E8 -9740000.0 -0.12 1.4685328E8 -1.75E7 -0.3 -0.298 -0.9219 3179162 Maybridge4_002722 CN(C)c1ccc(cc1)C2OCCN2C(=S)Nc3ccccc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L17 compound treatment 1.23003561E8 -3.13E7 -0.39 1.24686484E8 -3.96E7 -0.68 -0.7573 -0.966 3064601 Maybridge4_002723 Cc1ccc(cc1)C(=O)CSC2=NCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L18 compound treatment 1.43261162E8 -1.1E7 -0.14 1.40754263E8 -2.36E7 -0.4 -0.3831 -0.898 3179163 Maybridge4_002724 CC(C)CNC(=S)N1CCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L19 compound treatment 1.42763503E8 -1.15E7 -0.14 1.49813109E8 -1.45E7 -0.25 -0.2779 -0.9666 1286430 Maybridge4_002725 S=C1NCN(CN1)C(Cc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L20 compound treatment 1.37189323E8 -1.71E7 -0.21 1.41443789E8 -2.29E7 -0.39 -0.4286 -0.9597 3064602 Maybridge4_002726 CCOC(=O)NC(=S)Nc1ccc(cc1)N2CC(C)OC(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L21 compound treatment 1.35131677E8 -1.91E7 -0.24 1.41835812E8 -2.25E7 -0.39 -0.4421 -0.9741 3179164 Maybridge4_002727 NNC(=O)C1CCC(CC1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L22 compound treatment 1.19595697E8 -3.47E7 -0.44 1.29452029E8 -3.49E7 -0.6 -0.7298 -0.9879 1090059 Maybridge4_002728 CCOC(=O)NC(=S)c1ccc[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L23 mock treatment 1.50597072E8 -3680000.0 -0.05 1.49180591E8 -1.52E7 -0.26 -0.216 -0.82 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 L24 mock treatment 1.51251025E8 -3020000.0 -0.04 1.61263062E8 -3070000.0 -0.05 -0.064 -0.9871 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M01 compound treatment 1.11252164E8 -4.3E7 -0.54 9.959229E7 -6.47E7 -1.11 -1.1653 -0.9453 3179165 Maybridge4_002729 O=S(=O)(Cc1ccc2nonc2c1)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M02 compound treatment 1.15273246E8 -3.9E7 -0.49 1.09525632E8 -5.48E7 -0.94 -1.0094 -0.9539 3179166 Maybridge4_002730 CCOC(=O)c1cncc(C#CCOC(=O)c2ccc(Cl)cn2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M03 compound treatment 1.1902106E8 -3.53E7 -0.44 1.13578444E8 -5.08E7 -0.87 -0.9271 -0.9509 3064603 Maybridge4_002731 CN1c2sc(C)c(C)c2-c3nc(SCC(=O)C(C)(C)C)ncc3S1(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M04 compound treatment 1.19748975E8 -3.45E7 -0.43 1.18734847E8 -4.56E7 -0.78 -0.8582 -0.9614 3179167 Maybridge4_002732 Clc1cc(Cl)cc(NC(=O)Nc2cc(n[nH]2)c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M05 compound treatment 1.27695642E8 -2.66E7 -0.33 1.26831198E8 -3.75E7 -0.64 -0.6897 -0.9534 1536304 Maybridge4_002733 Clc1ccc(cc1)c2csc(COc3ccc4nonc4c3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M06 compound treatment 1.17006325E8 -3.73E7 -0.47 1.24480538E8 -3.99E7 -0.68 -0.813 -0.983 3179168 Maybridge4_002734 O=S(=O)(/C(=C/N1CCC(CC1)n2cccc2)/C#N)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M07 compound treatment 1.10696388E8 -4.36E7 -0.55 1.23840481E8 -4.05E7 -0.69 -0.8767 -0.9931 1203004 Maybridge4_002735 Cn1c(S)nnc1CC2Sc3ccccc3NC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M08 compound treatment 1.12463053E8 -4.18E7 -0.52 1.12555994E8 -5.18E7 -0.89 -0.9976 -0.9686 1245628 Maybridge4_002736 CCCn1c(=O)c(C#N)nn(c2ccc(OC)cc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M09 compound treatment 1.11215487E8 -4.31E7 -0.54 1.04578495E8 -5.98E7 -1.02 -1.1052 -0.9555 1544442 Maybridge4_002737 CCOC(=O)NC(=O)c1cn(Cc2ccco2)c(=O)n(Cc3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M10 compound treatment 1.29654717E8 -2.46E7 -0.31 1.22211023E8 -4.21E7 -0.72 -0.7282 -0.9284 3064605 Maybridge4_002738 FC(F)(F)Oc1ccc(NC(=O)OC2CN(C2)C(c3ccccc3)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M11 compound treatment 1.18383569E8 -3.59E7 -0.45 1.14253113E8 -5.01E7 -0.86 -0.9245 -0.9548 3179169 Maybridge4_002739 Cn1c(CSc2cc(nc3ccccc23)C(F)(F)F)nnc1SCC(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M12 compound treatment 1.17694244E8 -3.66E7 -0.46 1.17938237E8 -4.64E7 -0.79 -0.8861 -0.966 3179170 Maybridge4_002740 Cc1ccc2nc(cc(N3CCN(CC3)/C=C(/C#N)\S(=O)(=O)c4ccccn4)c2c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M13 compound treatment 1.38273886E8 -1.6E7 -0.2 1.30793764E8 -3.35E7 -0.57 -0.5479 -0.9008 3064606 Maybridge4_002741 COC(=O)c1scc2c(Sc3ccc(Cl)cc3)cc(nc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M14 compound treatment 1.37453465E8 -1.68E7 -0.21 1.42392671E8 -2.19E7 -0.38 -0.4148 -0.9628 1624356 Maybridge4_002742 Cn1c(S)nnc1CSC2CN(C2)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M15 compound treatment 1.17202899E8 -3.71E7 -0.47 1.1865741E8 -4.57E7 -0.78 -0.8817 -0.9692 1609003 Maybridge4_002743 Clc1ccc(Cn2ccnc2COC(=O)c3ccccc3Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M16 compound treatment 1.47439808E8 -6830000.0 -0.09 1.26029032E8 -3.83E7 -0.66 -0.5243 -0.7928 3179171 Maybridge4_002744 CCOC(=O)N1CCC(CC1)N/C=C(\C#N)/S(=O)(=O)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M17 compound treatment 1.38176749E8 -1.61E7 -0.2 1.40910734E8 -2.34E7 -0.4 -0.4263 -0.9496 3064607 Maybridge4_002745 Clc1ccc(SC2CS(=O)(=O)c3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M18 compound treatment 1.3632188E8 -1.8E7 -0.23 1.53091489E8 -1.12E7 -0.19 -0.2953 -0.9969 3179261 Maybridge4_002746 COc1ccc(cc1OC)S(=O)(=O)N(CCC(=O)O)Cc2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M19 compound treatment 1.04500054E8 -4.98E7 -0.62 1.06476612E8 -5.79E7 -0.99 -1.1418 -0.9753 3064609 Maybridge4_002747 CC(C)(C)S(=O)(=O)/C(=C/N1CCN(CC1)C(c2ccccc2)c3ccccc3)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M20 compound treatment 1.40098651E8 -1.42E7 -0.18 1.41469996E8 -2.29E7 -0.39 -0.4025 -0.9363 1049769 Maybridge4_002748 CC(C)NC(=O)c1ccccc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M21 compound treatment 1.20582037E8 -3.37E7 -0.42 8.7896879E7 -7.64E7 -1.31 -1.2241 -0.8902 3063912 Maybridge4_002749 CCOC(=O)C1CCN(CC1)/C=C(\C#N)/S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M22 compound treatment 1.19067227E8 -3.52E7 -0.44 1.23480811E8 -4.09E7 -0.7 -0.8068 -0.9754 1471006 Maybridge4_002750 Nc1cc(=O)n(Cc2ccccc2)c(=O)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M23 mock treatment 1.23841814E8 -3.04E7 -0.38 1.26840552E8 -3.75E7 -0.64 -0.7238 -0.9692 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 M24 mock treatment 1.1397358E8 -4.03E7 -0.51 1.2905897E8 -3.53E7 -0.6 -0.7845 -0.9961 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N01 compound treatment 1.18456931E8 -3.58E7 -0.45 1.26792694E8 -3.75E7 -0.64 -0.7721 -0.9847 3063913 Maybridge4_002751 Cn1c(SCC(=O)NCC=C)nnc1c2ccc3nonc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N02 compound treatment 9.959126E7 -5.47E7 -0.69 1.10447174E8 -5.39E7 -0.92 -1.1373 -0.9894 3063914 Maybridge4_002752 Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N03 compound treatment 1.19269629E8 -3.5E7 -0.44 1.45106208E8 -1.92E7 -0.33 -0.5432 -0.9899 1156673 Maybridge4_002753 O=S(=O)(N1CCC(CC1)C(c2ccccc2)c3ccccc3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N04 compound treatment 1.02658133E8 -5.16E7 -0.65 1.06571122E8 -5.78E7 -0.99 -1.157 -0.9789 3063915 Maybridge4_002754 CNC(=O)c1csc(Cc2c(Cl)sc3ccc(Cl)cc23)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N05 compound treatment 1.30610924E8 -2.37E7 -0.3 1.31968811E8 -3.24E7 -0.55 -0.6017 -0.9572 1656700 Maybridge4_002755 COc1ccc(cc1)n2c(N)cc(=O)[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N06 compound treatment 1.28754183E8 -2.55E7 -0.32 1.39400173E8 -2.49E7 -0.43 -0.5282 -0.99 3063916 Maybridge4_002756 CN(c1ccccc1)S(=O)(=O)c2sc3ccc(Cl)cc3c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N07 compound treatment 9.2843308E7 -6.14E7 -0.77 9.9595798E7 -6.47E7 -1.11 -1.3285 -0.9842 3179262 Maybridge4_002757 CCOC(=O)N1CCN(CC1)c2cc(nc3c(Cl)cccc23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N08 compound treatment 1.27865653E8 -2.64E7 -0.33 1.18803712E8 -4.55E7 -0.78 -0.7854 -0.9274 3179263 Maybridge4_002758 COc1ccc(OC(=O)/C=C/c2sc3ccccc3c2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N09 compound treatment 2.25705167E8 7.14E7 0.9 3.01717139E8 1.37E8 2.35 2.2965 0.9125 3063917 Maybridge4_002759 CCOC(=O)c1ccc2nc(cc(NC3CCN(Cc4ccccc4)CC3)c2c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N10 compound treatment 1.19172338E8 -3.51E7 -0.44 1.20979073E8 -4.34E7 -0.74 -0.8361 -0.9689 3179264 Maybridge4_002760 CNC(=S)NCc1sc2ccccc2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N11 compound treatment 1.20528116E8 -3.37E7 -0.42 1.31033747E8 -3.33E7 -0.57 -0.7024 -0.9893 1569047 Maybridge4_002761 CCc1ccc2[nH]c(cc2c1)C(=O)NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N12 compound treatment 1.05488158E8 -4.88E7 -0.61 1.10340322E8 -5.4E7 -0.92 -1.0863 -0.98 3063918 Maybridge4_002762 Cc1nc2cc(nn2c(C)c1Sc3nccc(n3)c4cccnc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N13 compound treatment 9.6020181E7 -5.83E7 -0.73 1.15366598E8 -4.9E7 -0.84 -1.1094 -0.9977 1306797 Maybridge4_002763 COc1cc2CCN=C(c3ccc(Cl)cc3)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N14 compound treatment 1.11872619E8 -4.24E7 -0.53 1.21315171E8 -4.3E7 -0.74 -0.8968 -0.9872 3063920 Maybridge4_002764 C(N1CCC(=N1)c2cccs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N15 compound treatment 1.16913473E8 -3.74E7 -0.47 1.28263641E8 -3.61E7 -0.62 -0.768 -0.9907 3179265 Maybridge4_002765 CC(C)(C)Sc1nc2ccccc2[nH]c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N16 compound treatment 1.11707087E8 -4.26E7 -0.53 1.19794589E8 -4.45E7 -0.76 -0.9167 -0.9848 1707053 Maybridge4_002766 CCOC(=O)NC(=S)c1ccc(OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N17 compound treatment 1.23771096E8 -3.05E7 -0.38 1.33537946E8 -3.08E7 -0.53 -0.6433 -0.9876 3179266 Maybridge4_002767 Clc1cccc(c1)C(=O)Nc2nccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N18 compound treatment 1.07693598E8 -4.66E7 -0.58 1.25084197E8 -3.93E7 -0.67 -0.8883 -0.9976 1022738 Maybridge4_002768 NS(=O)(=O)c1ccc(Cl)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N19 compound treatment 1.09972617E8 -4.43E7 -0.56 1.25273735E8 -3.91E7 -0.67 -0.8658 -0.9958 3179267 Maybridge4_002769 Cc1nnsc1c2nnc(S)n2C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N20 compound treatment 1.01800648E8 -5.25E7 -0.66 1.19651256E8 -4.47E7 -0.76 -1.0063 -0.9972 1602154 Maybridge4_002770 CC1CN(CC(C)O1)c2ccc(NC(=S)Nc3ccc(cc3)N4CC(C)OC(C)C4)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N21 compound treatment 1.09231028E8 -4.5E7 -0.57 1.27715542E8 -3.66E7 -0.63 -0.8428 -0.9987 1095185 Maybridge4_002771 Nc1c(sc2ncccc12)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N22 compound treatment 1.10656865E8 -4.36E7 -0.55 1.32731662E8 -3.16E7 -0.54 -0.7694 -1.0 3063921 Maybridge4_002772 OCCNC(=S)NC1CCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N23 mock treatment 1.19874111E8 -3.44E7 -0.43 1.26836367E8 -3.75E7 -0.64 -0.759 -0.9813 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 N24 mock treatment 1.17143474E8 -3.71E7 -0.47 1.26273939E8 -3.81E7 -0.65 -0.79 -0.9865 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O01 compound treatment 1.17353868E8 -3.69E7 -0.46 1.28917106E8 -3.54E7 -0.61 -0.7562 -0.9912 1227681 Maybridge4_002773 CSc1ncc(C(=O)NN)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O02 compound treatment 1.09428667E8 -4.48E7 -0.56 1.19281967E8 -4.51E7 -0.77 -0.9431 -0.988 3179268 Maybridge4_002774 Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O03 compound treatment 1.08712638E8 -4.56E7 -0.57 1.35964437E8 -2.84E7 -0.49 -0.7475 -0.9967 1733846 Maybridge4_002775 CNC(=O)c1cc(Br)cc2CCOc21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O04 compound treatment 1.15728894E8 -3.85E7 -0.48 1.33227413E8 -3.11E7 -0.53 -0.7184 -0.9988 3179269 Maybridge4_002776 FC(F)(F)Oc1ccc(NC(=O)Nc2cc(n[nH]2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O05 compound treatment 1.15720994E8 -3.86E7 -0.48 1.34470272E8 -2.99E7 -0.51 -0.7035 -0.9996 3063922 Maybridge4_002777 CCOC(=O)c1sc(COc2ccc3nonc3c2)nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O06 compound treatment 1.14741065E8 -3.95E7 -0.5 1.30616032E8 -3.37E7 -0.58 -0.7588 -0.9971 3179270 Maybridge4_002778 CC(C)(C)S(=O)(=O)/C(=C/N1CCC(CC1)n2cccc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O07 compound treatment 8.333378E7 -7.09E7 -0.89 8.7186999E7 -7.71E7 -1.32 -1.5631 -0.9815 3063923 Maybridge4_002779 CCSc1cc(nc2cc(nn12)C(C)(C)C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O08 compound treatment 1.09939786E8 -4.43E7 -0.56 1.24399472E8 -3.99E7 -0.68 -0.8766 -0.9948 3063924 Maybridge4_002780 CSc1nn(cc1C(=O)Nc2ccc(Cl)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O09 compound treatment 1.18226623E8 -3.6E7 -0.45 1.26287571E8 -3.8E7 -0.65 -0.7803 -0.9841 1030103 Maybridge4_002781 O=c1[nH]c(=O)n(cc1C#N)C2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O10 compound treatment 1.07356275E8 -4.69E7 -0.59 1.12043679E8 -5.23E7 -0.9 -1.0491 -0.9793 1309716 Maybridge4_002782 CSc1nc2c(Cl)cccc2c3n(C)[nH]c(=O)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O11 compound treatment 1.21651997E8 -3.26E7 -0.41 1.28931455E8 -3.54E7 -0.61 -0.7179 -0.9817 1606150 Maybridge4_002783 Cc1[nH]c2ccccc2c1SCC(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O12 compound treatment 1.11206709E8 -4.31E7 -0.54 1.16121609E8 -4.82E7 -0.83 -0.9656 -0.9789 1579140 Maybridge4_002784 CCOC(=O)Cn1n(C)c2c(cnc3n(C)nc(C)c32)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O13 compound treatment 1.14582787E8 -3.97E7 -0.5 1.14446091E8 -4.99E7 -0.85 -0.9559 -0.967 1697318 Maybridge4_002785 CCOC(=O)Cn1c(=O)c(cn(C(C)C)c1=O)C(=S)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O14 compound treatment 1.05387198E8 -4.89E7 -0.61 1.23053206E8 -4.13E7 -0.71 -0.9333 -0.9975 1214988 Maybridge4_002786 Clc1ccc(OC(=O)c2c(nnc3ccccc23)c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O15 compound treatment 1.16531756E8 -3.77E7 -0.47 1.1587913E8 -4.85E7 -0.83 -0.9213 -0.9646 3063958 Maybridge4_002787 COc1cc(nc2ccc(C#CCOC(=O)Nc3ccccc3)cc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O16 compound treatment 1.20567732E8 -3.37E7 -0.42 1.36194548E8 -2.81E7 -0.48 -0.6396 -0.9979 3063959 Maybridge4_002788 Clc1ccc(SCc2n[nH]c(=O)c3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O17 compound treatment 1.25236717E8 -2.9E7 -0.36 1.2586486E8 -3.85E7 -0.66 -0.7232 -0.961 1427896 Maybridge4_002789 Cc1ccc(cc1)S(=O)(=O)C2CS(=O)(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O18 compound treatment 1.0095181E8 -5.33E7 -0.67 1.07775382E8 -5.66E7 -0.97 -1.1576 -0.9837 3063960 Maybridge4_002790 COc1ccc(cc1OC)S(=O)(=O)N(CCC#N)C2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O19 compound treatment 1.11307964E8 -4.3E7 -0.54 1.35035144E8 -2.93E7 -0.5 -0.7358 -0.9994 1698976 Maybridge4_002791 Cn1c(=O)c(cn(c2ccccc2)c1=O)c3nc(cs3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O20 compound treatment 1.24888472E8 -2.94E7 -0.37 1.27636642E8 -3.67E7 -0.63 -0.7048 -0.9677 3179271 Maybridge4_002792 CCOC(=O)C1CCC(N1C(=O)Nc2ccc(Cl)cc2)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O21 compound treatment 1.17591094E8 -3.67E7 -0.46 1.30456365E8 -3.39E7 -0.58 -0.7354 -0.9934 3063961 Maybridge4_002793 FC(F)(F)c1cccc(NC(=O)CN2C(=O)CSc3ccc(cc23)C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O22 compound treatment 1.23416956E8 -3.09E7 -0.39 1.33430005E8 -3.09E7 -0.53 -0.6478 -0.9882 1142886 Maybridge4_002794 Nc1nc(ncc1S(=O)(=O)c2ccccc2)C3COc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O23 mock treatment 1.18680613E8 -3.56E7 -0.45 1.33262121E8 -3.11E7 -0.53 -0.6918 -0.9962 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 O24 mock treatment 1.16486675E8 -3.78E7 -0.47 1.42502711E8 -2.18E7 -0.37 -0.5994 -0.9931 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P01 compound treatment 1.28806698E8 -2.55E7 -0.32 1.4220319E8 -2.21E7 -0.38 -0.4938 -0.9964 1672516 Maybridge4_002795 O=C(Nc1ccc2nonc2c1)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P02 compound treatment 1.20204142E8 -3.41E7 -0.43 1.33954647E8 -3.04E7 -0.52 -0.6699 -0.9953 3179272 Maybridge4_002796 FC(F)(F)c1ccccc1NC(=S)Nc2ccc3C=CS(=O)(=O)c3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P03 compound treatment 1.27658916E8 -2.66E7 -0.33 1.51063065E8 -1.33E7 -0.23 -0.3967 -0.9824 3063964 Maybridge4_002797 CCCn1c(=O)n(c2ccccc2C)c3[nH]cnc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P04 compound treatment 1.19565051E8 -3.47E7 -0.44 1.36028317E8 -2.83E7 -0.48 -0.6505 -0.9986 1153341 Maybridge4_002798 Cc1c(CC(=O)NN)sc2ccc(Cl)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P05 compound treatment 1.28602429E8 -2.57E7 -0.32 1.45651753E8 -1.87E7 -0.32 -0.4538 -1.0 1289003 Maybridge4_002799 Cc1ccccc1n2ccc(=O)[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P06 compound treatment 1.10480584E8 -4.38E7 -0.55 1.16939849E8 -4.74E7 -0.81 -0.9621 -0.982 3179273 Maybridge4_002800 Cc1c(sc2ccc(Cl)cc12)C(=O)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P07 compound treatment 1.27721241E8 -2.66E7 -0.33 1.43130651E8 -2.12E7 -0.36 -0.4922 -0.9991 3063965 Maybridge4_002801 CSc1nnc(CNC(=O)OC(C)(C)C)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P08 compound treatment 1.34259109E8 -2.0E7 -0.25 1.42949166E8 -2.14E7 -0.37 -0.4364 -0.9831 3179274 Maybridge4_002802 Cc1c(COC(=O)c2ccccc2)sc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P09 compound treatment 1.33147571E8 -2.11E7 -0.27 1.37419139E8 -2.69E7 -0.46 -0.5132 -0.9655 3179275 Maybridge4_002803 Cn1c(CNC(=O)c2cccs2)nnc1SCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P10 compound treatment 1.36653453E8 -1.76E7 -0.22 1.42872207E8 -2.15E7 -0.37 -0.4161 -0.9704 3063968 Maybridge4_002804 Cc1c(CNC(=O)c2ccc(cc2)C(F)(F)F)sc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P11 compound treatment 1.25136611E8 -2.91E7 -0.37 1.39675325E8 -2.47E7 -0.42 -0.5569 -0.9974 1496234 Maybridge4_002805 CCc1ccc2[nH]c(cc2c1)C(=O)NC(C)COC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P12 compound treatment 1.28150044E8 -2.61E7 -0.33 1.35486673E8 -2.88E7 -0.49 -0.5809 -0.9802 1637130 Maybridge4_002806 Clc1ccc(cc1)N2N=C(CSc3nccc(n3)c4cccnc4)CC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P13 compound treatment 1.31465525E8 -2.28E7 -0.29 1.42249144E8 -2.21E7 -0.38 -0.4696 -0.9906 3179276 Maybridge4_002807 Clc1ccc(cc1)c2ccc(s2)C(=O)OCc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P14 compound treatment 1.29012356E8 -2.53E7 -0.32 1.32021655E8 -3.23E7 -0.55 -0.6152 -0.9651 3063969 Maybridge4_002808 CN1CCC(=N1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P15 compound treatment 1.30310875E8 -2.4E7 -0.3 1.37710308E8 -2.66E7 -0.46 -0.5348 -0.9796 3179277 Maybridge4_002809 FC(F)(F)c1ccc(CNC(=O)N/C=C/c2cccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P16 compound treatment 1.25516623E8 -2.88E7 -0.36 1.41947456E8 -2.24E7 -0.38 -0.5261 -0.9995 3063970 Maybridge4_002810 Oc1nnc(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P17 compound treatment 1.29477728E8 -2.48E7 -0.31 1.4204782E8 -2.23E7 -0.38 -0.4897 -0.9949 3179278 Maybridge4_002811 COc1ccc(cc1)c2nc(cs2)c3ccc(C)cc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P18 compound treatment 1.17564274E8 -3.67E7 -0.46 1.40982668E8 -2.34E7 -0.4 -0.6083 -0.9975 1676105 Maybridge4_002812 COc1ccc(cc1)c2nc(nc(=O)[nH]2)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P19 compound treatment 1.21284794E8 -3.3E7 -0.41 1.50811215E8 -1.35E7 -0.23 -0.4563 -0.9623 3063971 Maybridge4_002813 OCc1cnc(S)n1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P20 compound treatment 1.20764531E8 -3.35E7 -0.42 1.4988652E8 -1.44E7 -0.25 -0.4721 -0.968 1134458 Maybridge4_002814 CC1CN(CC(C)O1)c2ccc(NC(=S)NN)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P21 compound treatment 1.17242749E8 -3.7E7 -0.46 1.4263748E8 -2.17E7 -0.37 -0.5911 -0.9939 3063972 Maybridge4_002815 Cc1ccc2sc(cc2c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P22 compound treatment 1.13688387E8 -4.06E7 -0.51 1.41097272E8 -2.32E7 -0.4 -0.6413 -0.9925 3063973 Maybridge4_002816 CCCc1ccc(NC(=S)OCC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P23 mock treatment 1.15498641E8 -3.88E7 -0.49 1.35862349E8 -2.85E7 -0.49 -0.6886 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2056 P24 mock treatment 1.03700302E8 -5.06E7 -0.63 1.45196076E8 -1.91E7 -0.33 -0.6803 -0.9527 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A01 compound treatment 1.7272007E8 7480000.0 0.09 1.55981715E8 -1.13E7 -0.19 -0.0706 -0.3278 3179279 Maybridge4_002817 CCOC(=S)Nc1ccc(I)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A02 compound treatment 1.41263006E8 -2.4E7 -0.3 1.15274309E8 -5.2E7 -0.89 -0.8423 -0.8962 3179280 Maybridge4_002818 Cn1c(/C=C/C=C/N2CCCC2)nc3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A03 compound treatment 1.6640306E8 1170000.0 0.01 1.68953246E8 1660000.0 0.03 0.0304 0.9528 3063974 Maybridge4_002819 CCCn1c(n[nH]c1=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A04 compound treatment 1.52365081E8 -1.29E7 -0.16 1.5346457E8 -1.38E7 -0.24 -0.2816 -0.9826 3179380 Maybridge4_002820 CCOC(=O)c1cnc(S/C=C/C(=O)c2ccc(Cl)cc2)nc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A05 compound treatment 1.72315486E8 7080000.0 0.09 1.64058023E8 -3240000.0 -0.06 0.0236 0.2254 1487054 Maybridge4_002821 Cc1ccccc1S(=O)c2ccccc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A06 compound treatment 1.70411711E8 5180000.0 0.06 1.66281232E8 -1020000.0 -0.02 0.0336 0.5002 3064003 Maybridge4_002822 N(/C=N/c1ccc2ccccc2c1)c3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A07 compound treatment 1.70288653E8 5050000.0 0.06 1.70236057E8 2940000.0 0.05 0.0804 0.9934 1198685 Maybridge4_002823 CC(C)CC(NC(=O)Nc1cccc2ccccc12)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A08 compound treatment 1.79260453E8 1.4E7 0.18 1.6872381E8 1430000.0 0.02 0.1417 0.7976 3064005 Maybridge4_002824 FC(F)(F)c1ncncc1c2nnnn2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A09 compound treatment 1.48501461E8 -1.67E7 -0.21 1.44727402E8 -2.26E7 -0.39 -0.4216 -0.9589 3064006 Maybridge4_002825 CN(C)/C=C(\C(=S)c1ccccc1)/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A10 compound treatment 1.41823427E8 -2.34E7 -0.29 1.29994935E8 -3.73E7 -0.64 -0.6592 -0.9379 3064007 Maybridge4_002826 Clc1ccc(O/C=C/C(=O)c2ccc(Br)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A11 compound treatment 1.68410727E8 3180000.0 0.04 1.62757497E8 -4540000.0 -0.08 -0.0268 -0.3067 1652788 Maybridge4_002827 CN1C(=O)C(Cc2ccccc2)(Cc3ccccc3)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A12 compound treatment 1.67403384E8 2170000.0 0.03 1.5396352E8 -1.33E7 -0.23 -0.1422 -0.6185 3064008 Maybridge4_002828 O=c1[nH]c2ccccc2c(=O)n1CCNCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A13 compound treatment 1.65219012E8 -16200.0 0.0 1.54220016E8 -1.31E7 -0.22 -0.1584 -0.7078 3064009 Maybridge4_002829 C/C(=N\O)/C(=O)Nc1cccc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A14 compound treatment 1.59395754E8 -5840000.0 -0.07 1.42790058E8 -2.45E7 -0.42 -0.3484 -0.8182 3179381 Maybridge4_002830 Clc1ccc(/C=C(\C#N)/c2c[nH]c3ccccc23)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A15 compound treatment 1.61306863E8 -3930000.0 -0.05 1.37959178E8 -2.93E7 -0.5 -0.39 -0.7728 3179382 Maybridge4_002831 O=C(/C=C\1/Nc2[nH]c(=S)[nH]c(=O)c2NC1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A16 compound treatment 1.96783731E8 3.15E7 0.4 1.61412609E8 -5880000.0 -0.1 0.2086 0.5109 3064010 Maybridge4_002832 FC(F)(F)c1ccc(/C=C(\C#N)/c2cn(C(=O)C3CCC3)c4ccccc24)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A17 compound treatment 1.70385824E8 5150000.0 0.06 1.55264369E8 -1.2E7 -0.21 -0.1 -0.463 1477955 Maybridge4_002833 Cc1c(O)c(C(=O)c2nn[nH]n2)c(=O)n(c3ccccc3)c1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A18 compound treatment 1.84075141E8 1.88E7 0.24 1.76696731E8 9400000.0 0.16 0.2809 0.9824 1152993 Maybridge4_002834 COc1ccc(CC(=O)NN2C(=O)CSCC2=O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A19 compound treatment 1.81201471E8 1.6E7 0.2 1.67547587E8 251000.0 0.0 0.1447 0.7221 3179383 Maybridge4_002835 O=C(C/C(=C\1/CCc2ccccc2C1=O)/c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A20 compound treatment 1.78130404E8 1.29E7 0.16 1.70584776E8 3290000.0 0.06 0.1542 0.9002 3179384 Maybridge4_002836 CC1CC(CC(C)(C)C1)NC(=S)NCc2csc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A21 compound treatment 1.64400303E8 -835000.0 -0.01 1.55202117E8 -1.21E7 -0.21 -0.1538 -0.7419 1438428 Maybridge4_002837 CC12CCC3C(CC=C4CC(O)CCC34CO)C2CCC1OC(=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A22 compound treatment 1.84458403E8 1.92E7 0.24 1.7317682E8 5880000.0 0.1 0.2417 0.9249 3179385 Maybridge4_002838 CC(=O)Nc1ccc(cc1)C2=N/C(=C/c3cn(C(=O)C)c4ccccc34)/C(=O)O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A23 mock treatment 1.97885174E8 3.26E7 0.41 1.77949164E8 1.07E7 0.18 0.4186 0.9336 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 A24 mock treatment 1.89776582E8 2.45E7 0.31 1.75356642E8 8060000.0 0.14 0.3152 0.9344 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B01 compound treatment 1.51562168E8 -1.37E7 -0.17 1.61742342E8 -5550000.0 -0.1 -0.1885 -0.9613 1595249 Maybridge4_002839 COc1ccc(cc1)C2C(C(=O)O)c3ccccc3C(=O)N2Cc4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B02 compound treatment 1.64951012E8 -284000.0 0.0 1.76588821E8 9290000.0 0.16 0.11 0.6911 3064011 Maybridge4_002840 FC(F)(F)c1nnc(Nc2cccnc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B03 compound treatment 1.65423469E8 188000.0 0.0 1.81551963E8 1.43E7 0.24 0.1742 0.7139 1011958 Maybridge4_002841 CC(=O)Nc1ccc(Cc2ccc(NC(=O)C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B04 compound treatment 1.73108347E8 7870000.0 0.1 1.82756674E8 1.55E7 0.26 0.257 0.9097 3179386 Maybridge4_002842 O=C1N(C2CCCCC2)/C(=N/C3CCCCC3)/SC41CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B05 compound treatment 1.7923946E8 1.4E7 0.18 1.80564521E8 1.33E7 0.23 0.2848 0.9919 3064012 Maybridge4_002843 CS/C(=N\C#N)/N=c\1/nc(SC)n(C)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B06 compound treatment 1.76129502E8 1.09E7 0.14 1.83282391E8 1.6E7 0.27 0.2901 0.9485 3179387 Maybridge4_002844 Cc1cc(S)nc(n1)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B07 compound treatment 1.49923725E8 -1.53E7 -0.19 1.75419559E8 8120000.0 0.14 -0.0375 -0.1581 3064013 Maybridge4_002845 Cc1csc(Nc2c(C)cccc2C)[n+]1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B08 compound treatment 1.59953069E8 -5280000.0 -0.07 1.62284939E8 -5010000.0 -0.09 -0.1075 -0.9919 3179388 Maybridge4_002846 Cc1nc(nc(NCCNc2cc(ccn2)C(F)(F)F)c1Cl)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B09 compound treatment 1.73264528E8 8030000.0 0.1 1.73029962E8 5730000.0 0.1 0.1406 0.9999 3064014 Maybridge4_002847 Clc1ccc(/C=C(\C#N)/c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B10 compound treatment 1.64031371E8 -1200000.0 -0.02 1.57299781E8 -1.0E7 -0.17 -0.1317 -0.7665 1673007 Maybridge4_002848 COc1ccc(CCNC(=O)C(Sc2ccc(Cl)cc2)c3ccccc3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B11 compound treatment 1.65144306E8 -91000.0 0.0 1.62179546E8 -5120000.0 -0.09 -0.0627 -0.7163 1278976 Maybridge4_002849 CSc1nc2ccccc2c(=O)n1CCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B12 compound treatment 1.65856202E8 621000.0 0.01 1.60006822E8 -7290000.0 -0.12 -0.0827 -0.6617 3179389 Maybridge4_002850 CCOC(=O)/C(=N\O)/C1=CSC2=NNC(C)(C)N12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B13 compound treatment 1.6955607E8 4320000.0 0.05 1.66527204E8 -770000.0 -0.01 0.029 0.5201 1697626 Maybridge4_002851 Oc1ccccc1C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B14 compound treatment 1.80549071E8 1.53E7 0.19 1.69661813E8 2360000.0 0.04 0.1645 0.8377 1029066 Maybridge4_002852 OC(Cc1cccnc1)(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B15 compound treatment 1.8263442E8 1.74E7 0.22 1.62257144E8 -5040000.0 -0.09 0.0933 0.3977 3179390 Maybridge4_002853 Cn/1c(cs\c1=N/C(=S)NCCc2ccccc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B16 compound treatment 1.75139276E8 9900000.0 0.12 1.69982012E8 2690000.0 0.05 0.1204 0.9085 1414388 Maybridge4_002854 Cc1ccc2onc(OC(=O)NC(C)(C)C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B17 compound treatment 1.81939798E8 1.67E7 0.21 1.64145427E8 -3150000.0 -0.05 0.11 0.5085 3064015 Maybridge4_002855 CS/C(=N\c1ccc(Cl)cc1)/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B18 compound treatment 1.64515992E8 -719000.0 -0.01 1.60267147E8 -7030000.0 -0.12 -0.0915 -0.758 1450668 Maybridge4_002856 CNC(=O)Nc1cccc(c1)c2cc(no2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B19 compound treatment 1.73438568E8 8200000.0 0.1 1.48476379E8 -1.88E7 -0.32 -0.155 -0.4584 1567287 Maybridge4_002857 COc1cc(CSc2nnnn2c3ccc(C)cc3C)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B20 compound treatment 1.72751583E8 7520000.0 0.09 1.706265E8 3330000.0 0.06 0.107 0.9709 1505699 Maybridge4_002858 COC(=O)c1c(NC(=O)N(C)C)onc1c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B21 compound treatment 1.73860291E8 8630000.0 0.11 1.72286987E8 4990000.0 0.09 0.1369 0.9932 1506761 Maybridge4_002859 NCCSC(=S)NC1CCCCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B22 compound treatment 1.86600477E8 2.14E7 0.27 1.78441207E8 1.11E7 0.19 0.3244 0.9861 3064016 Maybridge4_002860 CN(C)/C=N/C1NC(=O)N(C)C(=N1)C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B23 mock treatment 1.82842052E8 1.76E7 0.22 1.68578434E8 1280000.0 0.02 0.1717 0.7735 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 B24 mock treatment 1.85177341E8 1.99E7 0.25 1.67145666E8 -151000.0 0.0 0.1751 0.6998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C01 compound treatment 1.35681469E8 -2.96E7 -0.37 1.22812057E8 -4.45E7 -0.76 -0.8006 -0.9453 1030385 Maybridge4_002861 S=C(NC1CCCCC1)C(=S)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C02 compound treatment 1.16953508E8 -4.83E7 -0.61 1.10134673E8 -5.72E7 -0.98 -1.1202 -0.9734 3064017 Maybridge4_002862 Clc1ccc(cc1)C(=O)c2[n+]([N-]C#N)ccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C03 compound treatment 1.39236145E8 -2.6E7 -0.33 1.43123515E8 -2.42E7 -0.41 -0.5232 -0.9931 3179391 Maybridge4_002863 CCCn1c(n[nH]c1=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C04 compound treatment 1.05724242E8 -5.95E7 -0.75 1.04781096E8 -6.25E7 -1.07 -1.2846 -0.9845 3064018 Maybridge4_002864 O=C(/C=C/Sc1ccccn1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C05 compound treatment 1.61275627E8 -3960000.0 -0.05 1.55995574E8 -1.13E7 -0.19 -0.1719 -0.8607 3179392 Maybridge4_002865 CCNS(=O)(=O)c1ccc(Cl)cc1I 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C06 compound treatment 1.58785688E8 -6450000.0 -0.08 1.42131624E8 -2.52E7 -0.43 -0.3618 -0.8255 3064054 Maybridge4_002866 CC1C(O/C(=N\S(=O)(=O)c2ccc(Cl)cc2)/N1C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C07 compound treatment 1.58184639E8 -7050000.0 -0.09 1.52420326E8 -1.49E7 -0.25 -0.2426 -0.9 1049317 Maybridge4_002867 OC(=O)CCNC(=O)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C08 compound treatment 1.39599411E8 -2.56E7 -0.32 1.38872378E8 -2.84E7 -0.49 -0.5715 -0.9798 3064055 Maybridge4_002868 Oc1c([I+]c2ccccc2)c(=O)[nH]c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C09 compound treatment 1.52053201E8 -1.32E7 -0.17 1.45198809E8 -2.21E7 -0.38 -0.3844 -0.9311 3064056 Maybridge4_002869 N#CC(Cc1ccccc1)(Cc2ccccc2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C10 compound treatment 1.38966132E8 -2.63E7 -0.33 1.35575321E8 -3.17E7 -0.54 -0.617 -0.9714 1357025 Maybridge4_002870 CC1(C)c2cc(Cl)ccc2-n3c1cc(O)c(c4ccccc4)c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C11 compound treatment 1.29725583E8 -3.55E7 -0.45 1.31717033E8 -3.56E7 -0.61 -0.7456 -0.9882 1019915 Maybridge4_002871 Cc1ccc(cc1)C(O)c2nccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C12 compound treatment 1.27670074E8 -3.76E7 -0.47 1.31972227E8 -3.53E7 -0.6 -0.7608 -0.9924 3064058 Maybridge4_002872 O/N=C/C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C13 compound treatment 1.22611796E8 -4.26E7 -0.53 1.29068443E8 -3.82E7 -0.65 -0.8408 -0.995 3064059 Maybridge4_002873 CC(C)/C(=N/O)/c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C14 compound treatment 1.22605603E8 -4.26E7 -0.53 1.24462413E8 -4.28E7 -0.73 -0.8966 -0.988 1733383 Maybridge4_002874 CCCCC1(CO)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C15 compound treatment 1.23667619E8 -4.16E7 -0.52 1.30359287E8 -3.69E7 -0.63 -0.8158 -0.9954 1134906 Maybridge4_002875 NC(=O)NC1C(Oc2ccccc2C1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C16 compound treatment 1.36230283E8 -2.9E7 -0.36 1.35760155E8 -3.15E7 -0.54 -0.639 -0.9816 1708436 Maybridge4_002876 CSc1[nH]nc(NS(=O)(=O)c2ccc(Cl)cc2)c1c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C17 compound treatment 1.52041175E8 -1.32E7 -0.17 1.53377801E8 -1.39E7 -0.24 -0.2855 -0.9842 1325632 Maybridge4_002877 CCCCc1c(O)c2cccc3c4ccccc4n(c1=O)c32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C18 compound treatment 1.24515726E8 -4.07E7 -0.51 1.31881706E8 -3.54E7 -0.61 -0.7899 -0.9964 3179393 Maybridge4_002878 O=C1NCCN1CC/N=C/c2ccc(C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C19 compound treatment 1.51423049E8 -1.38E7 -0.17 1.33382134E8 -3.39E7 -0.58 -0.533 -0.8798 3064061 Maybridge4_002879 c1c2ccccc2c3ccc(oc13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C20 compound treatment 1.31899975E8 -3.33E7 -0.42 1.36752259E8 -3.05E7 -0.52 -0.6654 -0.9939 1357662 Maybridge4_002880 CC(C)c1ccc(NN2C(=O)CC(C2=O)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C21 compound treatment 1.20689507E8 -4.45E7 -0.56 1.20458801E8 -4.68E7 -0.8 -0.9621 -0.9844 1704922 Maybridge4_002881 COc1cc(C)c2C3CCC4(C)C(O)CCC4C3CCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C22 compound treatment 1.42420193E8 -2.28E7 -0.29 1.38510428E8 -2.88E7 -0.49 -0.5508 -0.9666 1187010 Maybridge4_002882 Fc1ccc(C(=O)OCCn2ncc3ccccc3c2=O)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C23 mock treatment 1.40945254E8 -2.43E7 -0.3 1.43102334E8 -2.42E7 -0.41 -0.5083 -0.9886 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 C24 mock treatment 1.46010894E8 -1.92E7 -0.24 1.3760404E8 -2.97E7 -0.51 -0.5299 -0.942 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D01 compound treatment 1.49370102E8 -1.59E7 -0.2 1.47818841E8 -1.95E7 -0.33 -0.3765 -0.9696 1248994 Maybridge4_002883 CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)CSCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D02 compound treatment 1.42563777E8 -2.27E7 -0.28 1.44653281E8 -2.26E7 -0.39 -0.4752 -0.9884 3064062 Maybridge4_002884 Cc1ccc(/N=C/2\SC3(CC3)C(=O)N2c4ccc(C)cc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D03 compound treatment 1.4690737E8 -1.83E7 -0.23 1.51949618E8 -1.53E7 -0.26 -0.3483 -0.9978 3179394 Maybridge4_002885 Clc1cccc(c1)/C(=C/C=C/c2ccccc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D04 compound treatment 1.46548836E8 -1.87E7 -0.23 1.44252691E8 -2.3E7 -0.39 -0.4447 -0.9691 3064063 Maybridge4_002886 Clc1cccc(/N=C/2\SC3(CC3)C(=O)N2c4cccc(Cl)c4)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D05 compound treatment 1.45104257E8 -2.01E7 -0.25 1.48107286E8 -1.92E7 -0.33 -0.4108 -0.9916 3179395 Maybridge4_002887 CCc1nn(C)c2c(=O)c(=O)c2n(C)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D06 compound treatment 1.14742209E8 -5.05E7 -0.63 1.58597135E8 -8700000.0 -0.15 -0.5532 -0.8502 3064064 Maybridge4_002888 CC1=NNC(=O)C1Oc2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D07 compound treatment 1.09648207E8 -5.56E7 -0.7 1.54640852E8 -1.27E7 -0.22 -0.6463 -0.8851 3179396 Maybridge4_002889 CSC(=N)Nc1c(Cl)cccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D08 compound treatment 1.47432999E8 -1.78E7 -0.22 1.50215561E8 -1.71E7 -0.29 -0.3647 -0.9911 3179397 Maybridge4_002890 Cc1nc(nc(NCCNc2ccc(cn2)C(F)(F)F)c1Cl)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D09 compound treatment 1.33641535E8 -3.16E7 -0.4 1.47210909E8 -2.01E7 -0.34 -0.5234 -0.9975 3064065 Maybridge4_002891 Cc1cc(O)nc(SCC(=O)c2ccc(F)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D10 compound treatment 1.07639924E8 -5.76E7 -0.72 1.50170701E8 -1.71E7 -0.29 -0.7182 -0.9211 1513804 Maybridge4_002892 CCOC(=O)c1c(C)c(ccc1N(C)C)C2NC(=O)NC=C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D11 compound treatment 1.43897512E8 -2.13E7 -0.27 1.46103431E8 -2.12E7 -0.36 -0.4458 -0.9888 3064066 Maybridge4_002893 O=C(CSc1nc2ccccc2c(=O)n1Cc3ccco3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D12 compound treatment 1.49660028E8 -1.56E7 -0.2 1.49781092E8 -1.75E7 -0.3 -0.3502 -0.9785 3179501 Maybridge4_002894 CC(C)(C)c1ccc(cc1)/C(=N/O)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D13 compound treatment 1.55526799E8 -9710000.0 -0.12 1.46783532E8 -2.05E7 -0.35 -0.3344 -0.8998 1669360 Maybridge4_002895 Clc1ccc(cc1)C(=O)Nc2cc(Cl)ccc2C(=O)OCC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D14 compound treatment 1.74478135E8 9240000.0 0.12 1.67468237E8 171000.0 0.0 0.0841 0.7248 3064067 Maybridge4_002896 CC(C)Nc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D15 compound treatment 1.5324218E8 -1.2E7 -0.15 1.49101951E8 -1.82E7 -0.31 -0.3266 -0.9443 3064068 Maybridge4_002897 S=C(NC1CCCCC1)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D16 compound treatment 1.47861218E8 -1.74E7 -0.22 1.58411268E8 -8890000.0 -0.15 -0.2617 -0.9845 1715674 Maybridge4_002898 CN(C)c1nc(cc2C(=O)NC(=O)c21)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D17 compound treatment 1.54475631E8 -1.08E7 -0.13 1.51910508E8 -1.54E7 -0.26 -0.2817 -0.9518 3064069 Maybridge4_002899 CN(C)/C(=N/c1cc(C)c(C)cc1C)/NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D18 compound treatment 1.38530723E8 -2.67E7 -0.33 1.33759939E8 -3.35E7 -0.57 -0.6428 -0.9671 3179502 Maybridge4_002900 COc1ccc(/N=c/2\scc(C)n2C(=O)c3ccccc3Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D19 compound treatment 1.52205204E8 -1.3E7 -0.16 1.43487602E8 -2.38E7 -0.41 -0.4038 -0.9195 1153907 Maybridge4_002901 COc1ccc(OCC(O)CNC(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D20 compound treatment 1.34065913E8 -3.12E7 -0.39 1.44206828E8 -2.31E7 -0.4 -0.556 -1.0 3064070 Maybridge4_002902 Clc1cccc(Cl)c1c2cc(on2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D21 compound treatment 1.51078107E8 -1.42E7 -0.18 1.45478053E8 -2.18E7 -0.37 -0.3897 -0.9422 1636805 Maybridge4_002903 Brc1ccc(OCC2CN(C(=O)O2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D22 compound treatment 1.51116898E8 -1.41E7 -0.18 1.47052226E8 -2.02E7 -0.35 -0.3703 -0.9514 3064071 Maybridge4_002904 CC(C)c1nc(/N=C/N(C)C)nc(=O)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D23 mock treatment 1.37291405E8 -2.79E7 -0.35 1.38625859E8 -2.87E7 -0.49 -0.5949 -0.9864 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 D24 mock treatment 1.35169834E8 -3.01E7 -0.38 1.3429661E8 -3.3E7 -0.56 -0.6661 -0.9807 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E01 compound treatment 1.16877744E8 -4.84E7 -0.61 1.40671461E8 -2.66E7 -0.46 -0.7512 -0.9901 3179503 Maybridge4_002905 O=C(CSc1ccccn1)Nc2ccccc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E02 compound treatment 1.1656114E8 -4.87E7 -0.61 1.46475303E8 -2.08E7 -0.36 -0.6838 -0.9672 3179504 Maybridge4_002906 N#CC1(N=C2C=CC=CN2N=C1c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E03 compound treatment 1.15323795E8 -4.99E7 -0.63 1.54075026E8 -1.32E7 -0.23 -0.6028 -0.9054 3064072 Maybridge4_002907 O=C1OC2(CCCCC2)OC(=O)C1=Cc3ccoc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E04 compound treatment 1.23968529E8 -4.13E7 -0.52 1.53189348E8 -1.41E7 -0.24 -0.5368 -0.9397 3179505 Maybridge4_002908 FC(F)(F)c1cc(nc(S/C=C/C(=O)c2ccccc2)c1C#N)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E05 compound treatment 1.28711155E8 -3.65E7 -0.46 1.78678577E8 1.14E7 0.19 -0.1862 -0.374 3064073 Maybridge4_002909 CNS(=O)(=O)c1ccc(Br)cc1I 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E06 compound treatment 1.34610345E8 -3.06E7 -0.38 1.64588075E8 -2710000.0 -0.05 -0.3044 -0.7867 3179506 Maybridge4_002910 CC(=O)O[C@@H]1O[C@@H]2CO[C@H](O[C@H]2[C@H](OC(=O)C)[C@H]1OC(=O)C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E07 compound treatment 1.2370894E8 -4.15E7 -0.52 1.76805691E8 9510000.0 0.16 -0.2533 -0.464 1547193 Maybridge4_002911 CCNS(=O)(=O)c1cccc2c(N)cccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E08 compound treatment 1.40422577E8 -2.48E7 -0.31 1.64356149E8 -2940000.0 -0.05 -0.2557 -0.8109 1448662 Maybridge4_002912 CCc1c(O)c(Cc2ccccc2)c(=O)n(c3nccs3)c1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E09 compound treatment 1.3044037E8 -3.48E7 -0.44 1.57894422E8 -9400000.0 -0.16 -0.4225 -0.9081 3179507 Maybridge4_002913 CCOC(=O)C(C#N)C1(C(=NN(C1=O)c2ccccc2)C)c3c(C)nn(c3O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E10 compound treatment 9.688653E7 -6.83E7 -0.86 1.1552809E8 -5.18E7 -0.89 -1.2329 -0.9999 3064074 Maybridge4_002914 Fc1ccc(cc1)C(=O)/C=C/S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E11 compound treatment 1.08996471E8 -5.62E7 -0.71 1.58000884E8 -9300000.0 -0.16 -0.6114 -0.8454 1495930 Maybridge4_002915 CC(C)C(OC(=O)c1ccccc1)c2nccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E12 compound treatment 1.35576681E8 -2.97E7 -0.37 1.69620564E8 2320000.0 0.04 -0.235 -0.6279 1260619 Maybridge4_002916 COC(=O)c1sc2c(C)cc(Cl)c(C)c2c1C(=O)Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E13 compound treatment 1.16945488E8 -4.83E7 -0.61 1.72141024E8 4840000.0 0.08 -0.3697 -0.6047 1268159 Maybridge4_002917 CCn1c(=O)cc(O)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E14 compound treatment 1.12663145E8 -5.26E7 -0.66 1.87597691E8 2.03E7 0.35 -0.2206 -0.2959 1134720 Maybridge4_002918 CCCCC1(COC(=O)c2ccc(OC)cc2)C(=O)N(N(C1=O)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E15 compound treatment 7.3911039E7 -9.13E7 -1.15 1.86184975E8 1.89E7 0.32 -0.5814 -0.4885 3063981 Maybridge4_002919 Clc1cc(Cl)c2c(=O)cc(oc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E16 compound treatment 1.35562366E8 -2.97E7 -0.37 1.89872944E8 2.26E7 0.39 0.0101 0.0187 3063982 Maybridge4_002920 O=C(CSc1nc(SCC(=O)c2ccccc2)c3ccccc3n1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E17 compound treatment 1.45643749E8 -1.96E7 -0.25 1.88161135E8 2.09E7 0.36 0.0788 0.1817 1617223 Maybridge4_002921 Oc1c(Cc2ccccc2)c(=O)n3c4ccccc4c5cccc1c53 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E18 compound treatment 1.29734457E8 -3.55E7 -0.45 1.94284445E8 2.7E7 0.46 0.0118 0.0183 3063983 Maybridge4_002922 Clc1ccc(CCN2C(=O)CSC2=S)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E19 compound treatment 1.01631343E8 -6.36E7 -0.8 1.72904458E8 5610000.0 0.1 -0.4963 -0.6176 3179508 Maybridge4_002923 CCc1c(C)oc2cc3ccccc3c2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E20 compound treatment 1.45990292E8 -1.92E7 -0.24 1.90375278E8 2.31E7 0.4 0.1086 0.2346 1212790 Maybridge4_002924 O=C(CSc1nc2ccccc2c(=O)[nH]1)c3ccc(cc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E21 compound treatment 1.17975434E8 -4.73E7 -0.59 1.63266656E8 -4030000.0 -0.07 -0.468 -0.7841 3179509 Maybridge4_002925 CC(OC(=O)C)C1CCC2C3CC[C@H]4CC(=O)CCC4(C)C3CCC12C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E22 compound treatment 1.46318208E8 -1.89E7 -0.24 1.80386269E8 1.31E7 0.22 -0.0094 -0.0287 1296117 Maybridge4_002926 O=C(OCCn1ncc2ccccc2c1=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E23 mock treatment 1.38967903E8 -2.63E7 -0.33 1.89011896E8 2.17E7 0.37 0.0298 0.0601 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 E24 mock treatment 1.29344673E8 -3.59E7 -0.45 1.91728326E8 2.44E7 0.42 -0.0226 -0.0368 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F01 compound treatment 1.52221209E8 -1.3E7 -0.16 1.7799832E8 1.07E7 0.18 0.0141 0.0574 1646144 Maybridge4_002927 CCCCC1(CN2CCN(Cc3ccccc3)CC2)C(=O)N(N(C1=O)c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F02 compound treatment 1.63906683E8 -1330000.0 -0.02 2.00356296E8 3.31E7 0.57 0.3884 0.686 1353488 Maybridge4_002928 OC(COc1ccc(F)cc1)CS(=O)(=O)Cc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F03 compound treatment 1.1616552E8 -4.91E7 -0.62 1.91679938E8 2.44E7 0.42 -0.1401 -0.1884 3064021 Maybridge4_002929 CCc1ccc(cc1)/C(=C/C=C/c2ccccc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F04 compound treatment 1.46436115E8 -1.88E7 -0.24 2.02300495E8 3.5E7 0.6 0.2569 0.399 1107774 Maybridge4_002930 Fc1ccc(NC(=S)C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F05 compound treatment 1.64077097E8 -1160000.0 -0.01 1.86076271E8 1.88E7 0.32 0.217 0.6745 1733993 Maybridge4_002931 CCc1cccc(CC)c1NC(=S)Nc2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F06 compound treatment 1.50531587E8 -1.47E7 -0.18 1.83185526E8 1.59E7 0.27 0.0619 0.1883 3179510 Maybridge4_002932 FC(F)(F)c1ccc(cc1)C(=O)Nc2ccc(cc2)C3=NCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F07 compound treatment 1.39576673E8 -2.57E7 -0.32 1.85524958E8 1.82E7 0.31 -0.007 -0.0155 3064024 Maybridge4_002933 Cc1cccc(Cl)c1NC(=S)NC(Cc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F08 compound treatment 8.8233498E7 -7.7E7 -0.97 1.9431072E8 2.7E7 0.46 -0.356 -0.3325 1491434 Maybridge4_002934 C1CN(CCO1)c2nc(ns2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F09 compound treatment 1.54718032E8 -1.05E7 -0.13 2.23413778E8 5.61E7 0.96 0.586 0.6043 1641045 Maybridge4_002935 CC(C)(CO)NC(=S)NCC1CCCO1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F10 compound treatment 1.78040526E8 1.28E7 0.16 1.80112655E8 1.28E7 0.22 0.2687 0.9883 3179511 Maybridge4_002936 O/N=C/c1c(F)cccc1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F11 compound treatment 1.81475423E8 1.62E7 0.2 1.99985019E8 3.27E7 0.56 0.5397 0.9064 3179512 Maybridge4_002937 Sc1nc2ccccc2c(=O)n1c3ccc(Cl)c(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F12 compound treatment 1.61474391E8 -3760000.0 -0.05 1.990593E8 3.18E7 0.54 0.3511 0.6433 3064025 Maybridge4_002938 Cc1cc(nn1c2ccccc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F13 compound treatment 1.62516683E8 -2720000.0 -0.03 1.95455043E8 2.82E7 0.48 0.3167 0.6554 3064027 Maybridge4_002939 Clc1ccc(cc1)C(=O)COC(=O)c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F14 compound treatment 1.68916946E8 3680000.0 0.05 2.19704014E8 5.24E7 0.9 0.667 0.7425 3179513 Maybridge4_002940 CC(C)Sc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F15 compound treatment 1.61149964E8 -4090000.0 -0.05 1.98832847E8 3.15E7 0.54 0.3455 0.6371 3179514 Maybridge4_002941 CCOC(=O)c1ccc(NC(=N)SCc2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F16 compound treatment 1.54567148E8 -1.07E7 -0.13 1.84212277E8 1.69E7 0.29 0.1101 0.3452 3064028 Maybridge4_002942 Cc1onc(c1N)c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F17 compound treatment 1.57540534E8 -7690000.0 -0.1 1.90123363E8 2.28E7 0.39 0.208 0.5169 3064029 Maybridge4_002943 Cc1cc(C)c(NC(=N)NN)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F18 compound treatment 1.6214985E8 -3090000.0 -0.04 1.784466E8 1.11E7 0.19 0.1076 0.5525 3179515 Maybridge4_002944 COC(=O)c1c(noc1C(=O)NN)c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F19 compound treatment 1.40472478E8 -2.48E7 -0.31 1.88748413E8 2.15E7 0.37 0.04 0.0832 1249379 Maybridge4_002945 COc1c(Cl)cccc1c2cn3ccc(C)cc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F20 compound treatment 1.41582154E8 -2.37E7 -0.3 1.55369142E8 -1.19E7 -0.2 -0.3542 -0.9834 1721352 Maybridge4_002946 Oc1nsc(Nc2ccccc2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F21 compound treatment 1.48636654E8 -1.66E7 -0.21 1.89272142E8 2.2E7 0.38 0.1188 0.2762 1132779 Maybridge4_002947 COc1ccc(COCC(O)CS(=O)(=O)c2ccc(OC)c(OC)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F22 compound treatment 1.4077656E8 -2.45E7 -0.31 2.01981324E8 3.47E7 0.59 0.2029 0.3036 3064075 Maybridge4_002948 CC(C)(C)C(=O)OCc1nc(cs1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F23 mock treatment 1.44923912E8 -2.03E7 -0.25 1.90380596E8 2.31E7 0.4 0.0992 0.2111 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 F24 mock treatment 1.32343119E8 -3.29E7 -0.41 1.72659084E8 5360000.0 0.09 -0.2269 -0.5367 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G01 compound treatment 1.42841115E8 -2.24E7 -0.28 1.71330768E8 4030000.0 0.07 -0.1498 -0.5179 1511541 Maybridge4_002949 Fc1ccc(NC(=O)C(=S)NC2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G02 compound treatment 1.53503739E8 -1.17E7 -0.15 1.7070546E8 3410000.0 0.06 -0.0628 -0.3967 1391130 Maybridge4_002950 Clc1ccc(Nc2nnc3c4ccccc4c5ccccc5c3n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G03 compound treatment 1.54466196E8 -1.08E7 -0.14 1.80744079E8 1.34E7 0.23 0.0672 0.2519 3179516 Maybridge4_002951 CC1C(=NN(C1=O)c2ccccc2)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G04 compound treatment 1.03896495E8 -6.13E7 -0.77 1.34842858E8 -3.25E7 -0.56 -0.9369 -0.9872 3179517 Maybridge4_002952 Cc1ccc2[nH]c(S/C=C/C(=O)c3ccccc3)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G05 compound treatment 1.7100551E8 5770000.0 0.07 1.98562117E8 3.13E7 0.54 0.4296 0.7955 1247714 Maybridge4_002953 CNS(=O)(=O)c1c(I)ccc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G06 compound treatment 1.86327088E8 2.11E7 0.26 1.95640646E8 2.83E7 0.49 0.5302 0.9593 3179612 Maybridge4_002954 CC(=O)N1[C@H](SC(C)(C)[C@@H]1C(=O)O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G07 compound treatment 1.95986764E8 3.08E7 0.39 2.17995332E8 5.07E7 0.87 0.8864 0.9334 1286617 Maybridge4_002955 COc1cc2OC(C)(C)CC(=O)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G08 compound treatment 1.27493122E8 -3.77E7 -0.47 2.17117809E8 4.98E7 0.85 0.2683 0.275 3179613 Maybridge4_002956 CC(=O)OC(C#N)[C@H]1O[C@@H]2OC(C)(C)O[C@@H]2[C@H]1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G09 compound treatment 1.71653601E8 6420000.0 0.08 1.94810394E8 2.75E7 0.47 0.39 0.8161 3064077 Maybridge4_002957 OC(=O)CCc1n[nH]c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G10 compound treatment 1.89270389E8 2.4E7 0.3 1.95076745E8 2.78E7 0.48 0.5495 0.9758 3064078 Maybridge4_002958 Cc1c(cnn1c2ccccc2)c3nnnn3c4ccc(C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G11 compound treatment 1.89650165E8 2.44E7 0.31 1.93580963E8 2.63E7 0.45 0.5347 0.9824 3179614 Maybridge4_002959 O=S(CC#N)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G12 compound treatment 1.80140888E8 1.49E7 0.19 2.03297715E8 3.6E7 0.62 0.568 0.882 3179615 Maybridge4_002960 FC(F)(F)c1cccc(OC(=O)c2cc3ccc4ccccc4c3s2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G13 compound treatment 1.77609153E8 1.24E7 0.16 1.93435269E8 2.61E7 0.45 0.4261 0.8998 3064081 Maybridge4_002961 CC(C)CC(C(O)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G14 compound treatment 1.86422464E8 2.12E7 0.27 1.98428283E8 3.11E7 0.53 0.5648 0.9484 1388837 Maybridge4_002962 CCCCC1(COC(=O)Nc2cccc(Cl)c2)C(=O)N(N(C1=O)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G15 compound treatment 1.86699763E8 2.15E7 0.27 2.07219291E8 3.99E7 0.68 0.6736 0.9171 3064082 Maybridge4_002963 NC1=NC(C(N1)C(=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G16 compound treatment 1.8209418E8 1.69E7 0.21 1.9070224E8 2.34E7 0.4 0.4328 0.9554 3179616 Maybridge4_002964 CSc1nc2ccccc2c(=O)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G17 compound treatment 7.5985677E7 -8.92E7 -1.12 8.6923092E7 -8.04E7 -1.38 -1.7645 -0.9948 3179617 Maybridge4_002965 O=c1ss/c(=N/Cc2ccccc2)/n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G18 compound treatment 1.32174474E8 -3.31E7 -0.41 1.47230667E8 -2.01E7 -0.34 -0.5361 -0.9956 3064083 Maybridge4_002966 S=C(NCC1CC1)NCc2csc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G19 compound treatment 1.93009102E8 2.78E7 0.35 1.94664298E8 2.74E7 0.47 0.5776 0.9894 1378931 Maybridge4_002967 C(NC1CCCCC1)C(CNC2CCCCC2)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G20 compound treatment 1.79464114E8 1.42E7 0.18 2.02661325E8 3.54E7 0.61 0.5543 0.8782 3064084 Maybridge4_002968 CC(C)(C)c1ccc(NC(=O)c2cnccn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G21 compound treatment 1.55652419E8 -9580000.0 -0.12 1.77751265E8 1.05E7 0.18 0.0415 0.1927 1050158 Maybridge4_002969 COc1ccc2C3CCC4(C)C(CCC4=O)C3CCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G22 compound treatment 1.55988696E8 -9250000.0 -0.12 1.60594308E8 -6700000.0 -0.11 -0.1631 -1.0 1218870 Maybridge4_002970 O=C(Nc1cccnc1)c2cc3CCc4ccccc4-c3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G23 mock treatment 1.85839777E8 2.06E7 0.26 2.09952075E8 4.27E7 0.73 0.6991 0.9025 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 G24 mock treatment 1.76853681E8 1.16E7 0.15 1.93728601E8 2.64E7 0.45 0.423 0.8899 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H01 compound treatment 1.92964241E8 2.77E7 0.35 1.99618087E8 3.23E7 0.55 0.6372 0.975 1264780 Maybridge4_002971 COc1ccc(NC(=O)C2CC(=C(C)CC2C(=O)O)C)c(n1)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H02 compound treatment 1.82415453E8 1.72E7 0.22 2.08629028E8 4.13E7 0.71 0.6527 0.8825 1569864 Maybridge4_002972 COc1ccc(COCC(O)CS(=O)(=O)Cc2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H03 compound treatment 1.74153426E8 8920000.0 0.11 2.07200195E8 3.99E7 0.68 0.5621 0.8121 1169171 Maybridge4_002973 OCCNN1C(=O)c2cccc3cccc(C1=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H04 compound treatment 1.27367289E8 -3.79E7 -0.48 2.18010088E8 5.07E7 0.87 0.2779 0.2809 1600308 Maybridge4_002974 Cc1onc(c1C2=NCCO2)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H05 compound treatment 1.84808757E8 1.96E7 0.25 2.22172834E8 5.49E7 0.94 0.8379 0.8629 3179618 Maybridge4_002975 Cc1cccc(C)c1Nc2nc3c(C)cc(C)c(C)c3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H06 compound treatment 2.0592907E8 4.07E7 0.51 2.12059787E8 4.48E7 0.77 0.9028 0.9805 1417835 Maybridge4_002976 OC1CCCCC1S(=O)(=O)Cc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H07 compound treatment 1.90335494E8 2.51E7 0.31 2.15947908E8 4.87E7 0.83 0.8115 0.9115 3064223 Maybridge4_002977 CCC(CO)NC(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H08 compound treatment 1.93406857E8 2.82E7 0.35 2.32300481E8 6.5E7 1.11 1.0367 0.888 3179619 Maybridge4_002978 Clc1ccc2oc(=S)n(Cc3ccccc3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H09 compound treatment 1.97336017E8 3.21E7 0.4 2.12433005E8 4.51E7 0.77 0.8311 0.9539 3064225 Maybridge4_002979 CNC(=S)NCCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H10 compound treatment 1.98234756E8 3.3E7 0.41 2.14947121E8 4.77E7 0.82 0.8695 0.9506 3179620 Maybridge4_002980 O=C(OCc1ccc2OCOc2c1)OCc3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H11 compound treatment 1.94542588E8 2.93E7 0.37 2.12806073E8 4.55E7 0.78 0.8108 0.9413 3179621 Maybridge4_002981 Cc1cc(C)nc(NC(=S)c2ccc(NC(=O)/C=C/C(=O)O)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H12 compound treatment 1.8661111E8 2.14E7 0.27 2.33469141E8 6.62E7 1.13 0.9906 0.851 3064227 Maybridge4_002982 NC(=N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H13 compound treatment 1.87964199E8 2.27E7 0.29 2.15703597E8 4.84E7 0.83 0.7875 0.8987 1447884 Maybridge4_002983 COc1cccc(C(=O)OCC(=O)c2ccccc2)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H14 compound treatment 1.9468205E8 2.94E7 0.37 2.11241411E8 4.39E7 0.75 0.7931 0.9464 3179622 Maybridge4_002984 CCOC(=O)c1cc(nc(S)c1C#N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H15 compound treatment 1.95665604E8 3.04E7 0.38 2.23353991E8 5.61E7 0.96 0.9485 0.9184 2077819 Maybridge4_002985 C[n+]1c(NC2CCCCC2)scc1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H16 compound treatment 1.88446119E8 2.32E7 0.29 2.28006472E8 6.07E7 1.04 0.9407 0.8717 1009495 Maybridge4_002986 CC(C)(C)C1=CC(=O)C(=CC1=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H17 compound treatment 1.93447684E8 2.82E7 0.35 2.26271897E8 5.9E7 1.01 0.9641 0.9012 3179623 Maybridge4_002987 CCc1ccc(NC(=N)NC(=N)N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H18 compound treatment 1.89044239E8 2.38E7 0.3 2.11468804E8 4.42E7 0.76 0.7459 0.9174 1395086 Maybridge4_002988 Cc1nc(nc(O)c1Cl)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H19 compound treatment 1.96475327E8 3.12E7 0.39 2.19645703E8 5.23E7 0.9 0.9108 0.9312 1725570 Maybridge4_002989 CC(C)(C)C(=O)Nc1ccc(cc1)c2cc3cc(Cl)ccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H20 compound treatment 1.29049039E8 -3.62E7 -0.45 1.4831472E8 -1.9E7 -0.32 -0.5507 -0.9866 1661405 Maybridge4_002990 Cc1ccc(NC(=S)C(C#N)C(=O)N)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H21 compound treatment 1.75953655E8 1.07E7 0.13 1.96003474E8 2.87E7 0.49 0.4425 0.8687 1723738 Maybridge4_002991 Clc1ccc(N2C(CC(=O)NC2=S)c3ccccc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H22 compound treatment 1.83700331E8 1.85E7 0.23 2.14207411E8 4.69E7 0.8 0.7316 0.8754 3179624 Maybridge4_002992 OCc1noc(n1)c2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H23 mock treatment 1.90953304E8 2.57E7 0.32 2.10468115E8 4.32E7 0.74 0.7507 0.931 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 H24 mock treatment 1.77034205E8 1.18E7 0.15 1.95685892E8 2.84E7 0.49 0.4483 0.8825 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I01 compound treatment 2.14709649E8 4.95E7 0.62 2.28688989E8 6.14E7 1.05 1.182 0.9684 1401560 Maybridge4_002993 Clc1ccc(NC(=O)Nc2ccccc2)c(SCc3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I02 compound treatment 2.19398456E8 5.42E7 0.68 2.32036733E8 6.47E7 1.11 1.2641 0.9724 1509609 Maybridge4_002994 CCSc1nnc2nc3c4ccccc4c5ccccc5c3nn12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I03 compound treatment 2.11682079E8 4.64E7 0.58 2.2843581E8 6.11E7 1.05 1.152 0.9618 3179625 Maybridge4_002995 O=C/1N(N=C(Nc2ccccc2)\C1=C\Nc3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I04 compound treatment 1.39238746E8 -2.6E7 -0.33 1.32235941E8 -3.51E7 -0.6 -0.655 -0.9589 3064579 Maybridge4_002996 Cn1cnnc1S/C=C/C(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I05 compound treatment 2.37169434E8 7.19E7 0.9 2.12290018E8 4.5E7 0.77 1.1827 0.9969 1063036 Maybridge4_002997 COc1cc(c(OC)cc1C(C)(C)C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I06 compound treatment 2.28849447E8 6.36E7 0.8 1.91275157E8 2.4E7 0.41 0.8545 0.9522 3179626 Maybridge4_002998 CSc1ccc(cc1)C2N[C@@H](C(=O)O)C(C)(C)S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I07 compound treatment 2.25681211E8 6.04E7 0.76 2.14862461E8 4.76E7 0.81 1.1119 0.9994 1248980 Maybridge4_002999 CCNS(=O)(=O)c1ccc(cc1)c2oc3cc(ccc3c2Cl)S(=O)(=O)NCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I08 compound treatment 1.96651471E8 3.14E7 0.39 1.92500272E8 2.52E7 0.43 0.5837 0.999 3064580 Maybridge4_003000 O=C/1N2CCCCSC2=N\C1=C\c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I09 compound treatment 2.20634018E8 5.54E7 0.69 2.18171704E8 5.09E7 0.87 1.1072 0.9937 1326747 Maybridge4_003001 CN(C)c1ccc(cc1)C2Nc3[nH]nc(C)c3C4=C2C(=O)CCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I10 compound treatment 2.35457722E8 7.02E7 0.88 2.28856852E8 6.16E7 1.05 1.368 0.996 3179627 Maybridge4_003002 S=c1[nH]nc(c2ccccc2)c(c1C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I11 compound treatment 2.44690167E8 7.95E7 1.0 2.166676E8 4.94E7 0.85 1.3024 0.9966 3063889 Maybridge4_003003 COc1ccc2CC(=O)CCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I12 compound treatment 2.07794463E8 4.26E7 0.53 1.95565817E8 2.83E7 0.48 0.7197 0.9988 1333404 Maybridge4_003004 CCCC1C2C(ON1c3ccc(Cl)c(Cl)c3)C(=O)N(C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I13 compound treatment 2.31389831E8 6.62E7 0.83 2.45806348E8 7.85E7 1.34 1.5371 0.9732 3063891 Maybridge4_003005 CC(C)CC(C(=O)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I14 compound treatment 2.53239486E8 8.8E7 1.1 2.26709641E8 5.94E7 1.02 1.4998 0.9992 1366549 Maybridge4_003006 Clc1cc(Cl)cc(c1)N2C(=O)CC(C2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I15 compound treatment 2.32003493E8 6.68E7 0.84 2.32679536E8 6.54E7 1.12 1.3837 0.9898 1552090 Maybridge4_003007 O=c1c(coc2ccccc12)c3nnn[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I16 compound treatment 2.35528751E8 7.03E7 0.88 2.16115576E8 4.88E7 0.84 1.2144 0.9996 1232818 Maybridge4_003008 CSc1nc2ccccc2c(=O)n1CC(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I17 compound treatment 6.38168908E8 4.73E8 5.93 5.93968468E8 4.27E8 7.3 9.3596 0.9947 3063892 Maybridge4_003009 COc1cc2ccc(=O)oc2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I18 compound treatment 2.27662823E8 6.24E7 0.78 2.27251524E8 6.0E7 1.03 1.2795 0.9911 3063893 Maybridge4_003010 CN/1\C(=N/C(=O)C)\NC(=O)\C1=C/c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I19 compound treatment 2.31130699E8 6.59E7 0.83 2.14663897E8 4.74E7 0.81 1.1579 1.0 1630014 Maybridge4_003011 NC(CCc1ccccc1Cl)c2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I20 compound treatment 2.35883287E8 7.06E7 0.89 2.25484745E8 5.82E7 1.0 1.331 0.9983 1530797 Maybridge4_003012 CCC1(CC)COC2(OC1)C(=O)Nc3ccc(F)cc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I21 compound treatment 2.21761315E8 5.65E7 0.71 2.05647396E8 3.84E7 0.66 0.9656 0.9993 3063895 Maybridge4_003013 Cc1cc(oc2cc3ccccc3c12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I22 compound treatment 2.24588292E8 5.94E7 0.74 2.2068392E8 5.34E7 0.91 1.1727 0.9948 3179717 Maybridge4_003014 Cc1cccc(c1)n2ncc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I23 mock treatment 2.37697088E8 7.25E7 0.91 2.27509099E8 6.02E7 1.03 1.3716 0.998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 I24 mock treatment 2.32339598E8 6.71E7 0.84 2.15054005E8 4.78E7 0.82 1.1733 0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J01 compound treatment 2.51914129E8 8.67E7 1.09 2.48442601E8 8.11E7 1.39 1.7511 0.9927 1715355 Maybridge4_003015 OC(=O)COCC(=O)Nc1cnccn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J02 compound treatment 2.45743897E8 8.05E7 1.01 2.59179234E8 9.19E7 1.57 1.8263 0.9771 1137874 Maybridge4_003016 Cc1cccc(C)c1n2c(n[nH]c2=S)C3CC4CCC3O4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J03 compound treatment 2.3397501E8 6.87E7 0.86 2.36417615E8 6.91E7 1.18 1.4464 0.9879 1593696 Maybridge4_003017 CN(C)N1C(=O)c2cccc3cccc(C1=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J04 compound treatment 2.43992118E8 7.88E7 0.99 2.84087958E8 1.17E8 2.0 2.1123 0.9472 3063897 Maybridge4_003018 CC(=O)Nc1ccc(Br)c(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J05 compound treatment 2.60182973E8 9.49E7 1.19 2.6090014E8 9.36E7 1.6 1.9752 0.9893 1249809 Maybridge4_003019 CC(C)c1ccc(Nc2nnns2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J06 compound treatment 2.06286132E8 4.11E7 0.51 2.23736285E8 5.64E7 0.97 1.0473 0.9566 1591476 Maybridge4_003020 CCN(CC)c1nc2ccccc2c(=O)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J07 compound treatment 2.40279201E8 7.5E7 0.94 2.55497727E8 8.82E7 1.51 1.7333 0.9742 1593840 Maybridge4_003021 CCN(CC)C(=S)Oc1ccccc1C(=O)Nc2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J08 compound treatment 2.6995041E8 1.05E8 1.31 2.91024709E8 1.24E8 2.12 2.4265 0.9736 3063932 Maybridge4_003022 Clc1cc(Cl)cc(Oc2nc(ns2)c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J09 compound treatment 2.55859648E8 9.06E7 1.14 2.29791389E8 6.25E7 1.07 1.5603 0.9995 1389101 Maybridge4_003023 OC(=O)CCC(=O)Nc1cccc(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J10 compound treatment 2.55580985E8 9.03E7 1.13 2.51968256E8 8.47E7 1.45 1.8263 0.9926 3063933 Maybridge4_003024 Cc1nc(S)c(C#N)c(C)c1CCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J11 compound treatment 2.51165753E8 8.59E7 1.08 2.33379831E8 6.61E7 1.13 1.5621 0.9997 3179718 Maybridge4_003025 Cc1nnc(Nc2cccc(Cl)c2C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J12 compound treatment 2.51358629E8 8.61E7 1.08 2.54231588E8 8.69E7 1.49 1.8162 0.9876 3063934 Maybridge4_003026 CNC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J13 compound treatment 2.32368951E8 6.71E7 0.84 2.23146921E8 5.59E7 0.96 1.2715 0.998 1446584 Maybridge4_003027 Cc1cc(Br)ccc1NC(=S)Nc2cccc(NC(=O)c3ccccc3O)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J14 compound treatment 5.90294414E8 4.25E8 5.33 6.04025349E8 4.37E8 7.48 9.0567 0.9863 3179719 Maybridge4_003028 CCOC(=O)c1cc(nc(O)c1C#N)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J15 compound treatment 2.84938516E8 1.2E8 1.5 2.67335772E8 1.0E8 1.71 2.2727 0.9979 3063936 Maybridge4_003029 O=c1cc(nc2scc(c3ccccc3)n12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J16 compound treatment 2.55832098E8 9.06E7 1.14 2.43029688E8 7.57E7 1.3 1.7203 0.9978 3179720 Maybridge4_003030 CCOC(=O)NC(=S)Nc1ccc(cc1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J17 compound treatment 2.58045044E8 9.28E7 1.16 2.73390717E8 1.06E8 1.82 2.1074 0.9769 3063937 Maybridge4_003031 Cc1nc(S)nc(O)c1CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J18 compound treatment 2.61524905E8 9.63E7 1.21 2.46200722E8 7.89E7 1.35 1.8092 0.9984 3179721 Maybridge4_003032 Sc1nnc([nH]1)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J19 compound treatment 2.53052583E8 8.78E7 1.1 2.39451164E8 7.22E7 1.24 1.6523 0.9984 3063939 Maybridge4_003033 COc1ccc(CCn2c(=S)[nH]c3cc(ccc23)C(F)(F)F)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J20 compound treatment 2.34355767E8 6.91E7 0.87 2.33136902E8 6.58E7 1.13 1.4101 0.9916 3179722 Maybridge4_003034 N#Cc1ccc(cc1)C2SCCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J21 compound treatment 2.2770531E8 6.25E7 0.78 2.26437465E8 5.91E7 1.01 1.27 0.992 3179723 Maybridge4_003035 FC(F)(F)c1cccc(c1)N2C(CC(=O)NC2=S)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J22 compound treatment 2.32855163E8 6.76E7 0.85 2.44789588E8 7.75E7 1.33 1.5378 0.9767 3063940 Maybridge4_003036 Oc1nnc(n2cccc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J23 mock treatment 2.33683238E8 6.84E7 0.86 2.3098475E8 6.37E7 1.09 1.378 0.993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 J24 mock treatment 2.32068002E8 6.68E7 0.84 2.2933055E8 6.2E7 1.06 1.3437 0.9932 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K01 compound treatment 1.06979845E8 -5.83E7 -0.73 1.21351137E8 -4.59E7 -0.79 -1.0729 -0.9993 1466072 Maybridge4_003037 CC(C)(C)c1ccc(CSCC(=O)Nc2ccccc2C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K02 compound treatment 1.20677424E8 -4.46E7 -0.56 1.36362433E8 -3.09E7 -0.53 -0.7697 -0.9996 1417054 Maybridge4_003038 COc1ccc(Cc2nc(n[nH]c2=S)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K03 compound treatment 1.15743265E8 -4.95E7 -0.62 1.38058449E8 -2.92E7 -0.5 -0.7929 -0.9943 1566854 Maybridge4_003039 Cc1ccc(C(=O)Nc2ccccc2)c(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K04 compound treatment 1.4530761E8 -1.99E7 -0.25 1.51947217E8 -1.53E7 -0.26 -0.3626 -0.9997 1404328 Maybridge4_003040 CCC1(CC)C(=O)c2cc3ccccc3cc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K05 compound treatment 1.43586802E8 -2.16E7 -0.27 1.6652349E8 -773000.0 -0.01 -0.2014 -0.7407 1489684 Maybridge4_003041 CNC(=O)c1ccccc1Sc2ccccc2C(=O)NC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K06 compound treatment 1.79671653E8 1.44E7 0.18 1.63712798E8 -3580000.0 -0.06 0.0847 0.4428 3179724 Maybridge4_003042 NC(=N)/N=C(\N)/Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K07 compound treatment 1.43481369E8 -2.18E7 -0.27 1.5305424E8 -1.42E7 -0.24 -0.3654 -0.9984 3063986 Maybridge4_003043 COC(=O)c1c2ccccc2c(C)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K08 compound treatment 1.37743409E8 -2.75E7 -0.34 1.42077648E8 -2.52E7 -0.43 -0.5491 -0.9938 3179725 Maybridge4_003044 COc1ccc(/C=C\2/N=C3SC(C)C(=O)N3C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K09 compound treatment 1.38079752E8 -2.72E7 -0.34 1.72897634E8 5600000.0 0.1 -0.1731 -0.4891 3063988 Maybridge4_003045 C/C(=C\c1ccccc1)/C(=N/O)/C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K10 compound treatment 1.49612414E8 -1.56E7 -0.2 1.75503499E8 8210000.0 0.14 -0.0392 -0.1628 3179726 Maybridge4_003046 N#C/C(=C\C(=C\N1CCOCC1)\c2ccccc2)/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K11 compound treatment 1.49951614E8 -1.53E7 -0.19 1.58904186E8 -8390000.0 -0.14 -0.2372 -0.9899 1700846 Maybridge4_003047 CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n2ccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K12 compound treatment 1.5637117E8 -8860000.0 -0.11 1.82969422E8 1.57E7 0.27 0.1111 0.3825 1550463 Maybridge4_003048 O=C1CSCC(=O)N1c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K13 compound treatment 1.5308299E8 -1.22E7 -0.15 1.60564098E8 -6730000.0 -0.12 -0.1893 -0.9905 1209004 Maybridge4_003049 COC(=O)C1=C(O)C2(CC(=C(O)C(C1)(C2)C(=O)O)C(=O)OC)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K14 compound treatment 1.64348211E8 -887000.0 -0.01 1.78809872E8 1.15E7 0.2 0.1315 0.6661 3063990 Maybridge4_003050 FC(F)(F)Oc1ccc(/N=c/2\[nH]c(=O)c3ccccc3o2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K15 compound treatment 1.60225047E8 -5010000.0 -0.06 1.75324314E8 8030000.0 0.14 0.0527 0.3489 3179727 Maybridge4_003051 FC(F)(F)c1ccc(Oc2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K16 compound treatment 1.55071846E8 -1.02E7 -0.13 1.60884975E8 -6410000.0 -0.11 -0.1678 -0.9972 3063992 Maybridge4_003052 COC(=O)/C=C\1/NCC(CNC1=O)OC(=O)c2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K17 compound treatment 1.48779674E8 -1.65E7 -0.21 1.6743241E8 136000.0 0.0 -0.1443 -0.6991 1628564 Maybridge4_003053 C1Cc2nc(ccc2-c3ccccc13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K18 compound treatment 1.56431723E8 -8800000.0 -0.11 1.72218576E8 4920000.0 0.08 -0.0185 -0.1333 3179728 Maybridge4_003054 CC1CC(CC(C)(C)C1)NC(=S)Nc2ccc(I)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K19 compound treatment 1.4525176E8 -2.0E7 -0.25 1.66074717E8 -1220000.0 -0.02 -0.1921 -0.7635 3063993 Maybridge4_003055 Cn1c(=O)n(C)c2ncn(CCCCn3cnc4n(C)c(=O)n(C)c(=O)c34)c2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K20 compound treatment 1.57233096E8 -8000000.0 -0.1 1.66478499E8 -818000.0 -0.01 -0.0809 -0.7981 3179729 Maybridge4_003056 CSc1cccc(c1)N2C(=O)C3CC=C(C)CC3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K21 compound treatment 1.51820254E8 -1.34E7 -0.17 1.59752949E8 -7540000.0 -0.13 -0.2103 -0.9914 1568172 Maybridge4_003057 OCC(C(O)c1ccccc1)N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K22 compound treatment 1.39240148E8 -2.6E7 -0.33 1.43137458E8 -2.42E7 -0.41 -0.523 -0.9931 1396421 Maybridge4_003058 NNC(=O)c1cc2CCc3ccccc3-c2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K23 mock treatment 1.51011699E8 -1.42E7 -0.18 1.53533476E8 -1.38E7 -0.24 -0.2928 -0.9906 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 K24 mock treatment 1.49325336E8 -1.59E7 -0.2 1.50377256E8 -1.69E7 -0.29 -0.3459 -0.9835 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L01 compound treatment 1.51601923E8 -1.36E7 -0.17 1.40460034E8 -2.68E7 -0.46 -0.4458 -0.9094 3179730 Maybridge4_003059 Cc1c(sc2nc(nn12)C(F)(F)F)C(=O)Cc3c(O)c4ccccc4oc3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L02 compound treatment 1.50261772E8 -1.5E7 -0.19 1.42410753E8 -2.49E7 -0.43 -0.434 -0.9323 3063994 Maybridge4_003060 FC(F)(F)c1cc(cc(c1)C(F)(F)F)N2C(=O)CC3(CCCC3)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L03 compound treatment 1.61302162E8 -3930000.0 -0.05 1.54071215E8 -1.32E7 -0.23 -0.195 -0.8415 3179731 Maybridge4_003061 CCOc1ccc(Br)cc1/C=N/c2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L04 compound treatment 1.46697261E8 -1.85E7 -0.23 1.30391902E8 -3.69E7 -0.63 -0.6111 -0.9078 1505741 Maybridge4_003062 CC(C)c1ccc(NS(=O)(=O)c2ccc(cc2)N3C(=O)CCC3=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L05 compound treatment 1.5677903E8 -8460000.0 -0.11 1.458521E8 -2.14E7 -0.37 -0.3346 -0.8756 3064031 Maybridge4_003063 Nc1ccccc1NC(=S)Nc2ccccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L06 compound treatment 1.48584111E8 -1.67E7 -0.21 1.53649901E8 -1.36E7 -0.23 -0.3129 -0.9984 3064032 Maybridge4_003064 CN(C)c1nc2ccccc2c(=O)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L07 compound treatment 1.47390004E8 -1.78E7 -0.22 1.40419432E8 -2.69E7 -0.46 -0.4836 -0.9452 3179732 Maybridge4_003065 CCN(CC)C(=S)Oc1ccc(I)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L08 compound treatment 1.65358988E8 124000.0 0.0 1.5423645E8 -1.31E7 -0.22 -0.157 -0.7022 3179733 Maybridge4_003066 FC(F)(F)c1cc(Cl)c2nc(cn2c1)C(=O)NC(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L09 compound treatment 1.59210679E8 -6020000.0 -0.08 1.55041819E8 -1.23E7 -0.21 -0.2018 -0.9049 1015049 Maybridge4_003067 CC(=O)Nc1ccc(Cl)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L10 compound treatment 1.61048201E8 -4190000.0 -0.05 1.40543035E8 -2.68E7 -0.46 -0.361 -0.7831 3064035 Maybridge4_003068 CCOC(=O)/C(=N/O)/C1=NN=C(N)SC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L11 compound treatment 1.62192589E8 -3040000.0 -0.04 1.74731129E8 7430000.0 0.13 0.063 0.4742 3179734 Maybridge4_003069 CC(C)Nc1nnc(C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L12 compound treatment 1.71854636E8 6620000.0 0.08 1.60175721E8 -7120000.0 -0.12 -0.0275 -0.1863 3064037 Maybridge4_003070 CN(C)C(=O)Nc1cc(C)n(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L13 compound treatment 1.51865339E8 -1.34E7 -0.17 1.44241477E8 -2.31E7 -0.39 -0.3977 -0.9273 3179735 Maybridge4_003071 Cc1cccc(C)c1/N=C/2\NC(C)(CO)CS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L14 compound treatment 1.54403845E8 -1.08E7 -0.14 1.53418533E8 -1.39E7 -0.24 -0.2641 -0.9649 1316254 Maybridge4_003072 Cc1cc2C(=O)NC(=O)c2c(Sc3ccc(Cl)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L15 compound treatment 1.7893423E8 1.37E7 0.17 1.63351779E8 -3950000.0 -0.07 0.0738 0.3995 3064038 Maybridge4_003073 Clc1ccc(cc1)c2csc3nc(cc(=O)n23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L16 compound treatment 1.67882084E8 2650000.0 0.03 1.51440572E8 -1.59E7 -0.27 -0.1684 -0.616 1158628 Maybridge4_003074 CNC(=O)Nc1ccc(cc1Br)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L17 compound treatment 1.47176077E8 -1.81E7 -0.23 1.49574879E8 -1.77E7 -0.3 -0.3747 -0.9897 3064039 Maybridge4_003075 FC(F)(F)c1cc(cc(c1)C(F)(F)F)n2c(S)nc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L18 compound treatment 1.65277303E8 42000.0 0.0 1.56593741E8 -1.07E7 -0.18 -0.1292 -0.7051 1188106 Maybridge4_003076 Clc1cccc(Cl)c1c2nscc2NC(=O)NN3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L19 compound treatment 1.51168971E8 -1.41E7 -0.18 1.45186685E8 -2.21E7 -0.38 -0.3924 -0.9397 3064040 Maybridge4_003077 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2cn3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L20 compound treatment 1.51531161E8 -1.37E7 -0.17 1.64660349E8 -2640000.0 -0.05 -0.1535 -0.8635 3178150 Maybridge4_003078 CNC(=O)Oc1ccc(cc1)c2nc(CSc3ccc(Cl)cc3)cs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L21 compound treatment 1.42795665E8 -2.24E7 -0.28 1.53862311E8 -1.34E7 -0.23 -0.3617 -0.995 1216087 Maybridge4_003079 CC(C)c1ccc(NCC(O)CSc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L22 compound treatment 1.42909979E8 -2.23E7 -0.28 1.45073676E8 -2.22E7 -0.38 -0.467 -0.9887 3064086 Maybridge4_003080 OCc1nc(cs1)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L23 mock treatment 1.44964222E8 -2.03E7 -0.25 1.50856078E8 -1.64E7 -0.28 -0.3788 -0.9987 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 L24 mock treatment 1.46232302E8 -1.9E7 -0.24 1.52248255E8 -1.5E7 -0.26 -0.3507 -0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M01 compound treatment 1.03823847E8 -6.14E7 -0.77 1.11458897E8 -5.58E7 -0.96 -1.2206 -0.9943 1228182 Maybridge4_003081 O=C(Nc1ccc2OCOc2c1)C(=S)NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M02 compound treatment 1.09946893E8 -5.53E7 -0.69 1.22630751E8 -4.47E7 -0.76 -1.0311 -0.9988 3064088 Maybridge4_003082 CCOC(=O)CSc1nnc(c2ccccc2)c(=O)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M03 compound treatment 1.1158427E8 -5.37E7 -0.67 1.29851789E8 -3.74E7 -0.64 -0.9291 -0.9997 3178151 Maybridge4_003083 CC1(C)OC(=O)C(=Cc2ccoc2)C(=O)O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M04 compound treatment 1.07835508E8 -5.74E7 -0.72 1.36451682E8 -3.08E7 -0.53 -0.8825 -0.9884 3178152 Maybridge4_003084 C[C@]1(O)CCC2C3CC[C@H]4CC(=O)/C(=C/c5ccccc5)/CC4(C)C3CCC21C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M05 compound treatment 1.10792954E8 -5.44E7 -0.68 1.36158221E8 -3.11E7 -0.53 -0.8598 -0.9925 2077623 Maybridge4_003085 CNC(=O)c1ccccc1[S+]2N(C)C(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M06 compound treatment 1.2058214E8 -4.47E7 -0.56 1.48182506E8 -1.91E7 -0.33 -0.6275 -0.9672 3064090 Maybridge4_003086 Cc1ccc(cc1)C(=O)/C=C/Nc2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M07 compound treatment 1.21411703E8 -4.38E7 -0.55 1.30256311E8 -3.7E7 -0.63 -0.8371 -0.9975 3064091 Maybridge4_003087 FC(F)(F)C(=O)N1CCCc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M08 compound treatment 8.757032E7 -7.77E7 -0.97 8.9905617E7 -7.74E7 -1.32 -1.6257 -0.9886 3178153 Maybridge4_003088 CN(C)/C=C/C=C/1\N=C(OC1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M09 compound treatment 1.35837609E8 -2.94E7 -0.37 1.4274501E8 -2.46E7 -0.42 -0.5579 -0.9979 1045240 Maybridge4_003089 O(c1ccccc1)c2nc(Oc3ccccc3)nc(Oc4ccccc4)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M10 compound treatment 1.2507175E8 -4.02E7 -0.5 1.22895962E8 -4.44E7 -0.76 -0.8937 -0.9801 1341049 Maybridge4_003090 Oc1c(Cc2ccccc2)c(=O)n(c3ccccc3)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M11 compound treatment 1.33700917E8 -3.15E7 -0.4 1.34267029E8 -3.3E7 -0.57 -0.6795 -0.9847 1250198 Maybridge4_003091 CCN1c2cc(NC(=O)CC)ccc2C(C)CC1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M12 compound treatment 1.30793537E8 -3.44E7 -0.43 1.28589375E8 -3.87E7 -0.66 -0.774 -0.9785 1276296 Maybridge4_003092 COC(=O)c1cc(=O)n2CCSc2c1C(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M13 compound treatment 1.48003268E8 -1.72E7 -0.22 1.51485083E8 -1.58E7 -0.27 -0.3442 -0.9938 1660543 Maybridge4_003093 CCC(C)c1cc(N)nc2nc3ccccc3n12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M14 compound treatment 1.62632812E8 -2600000.0 -0.03 1.55073025E8 -1.22E7 -0.21 -0.171 -0.8077 1341769 Maybridge4_003094 Fc1ccc(cc1)N2C(=O)CC(C2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M15 compound treatment 1.41711848E8 -2.35E7 -0.3 1.56414267E8 -1.09E7 -0.19 -0.3404 -0.9754 3178154 Maybridge4_003095 CCOC(=O)CCc1c(CC(=O)OCC)c[nH]c1/C=N/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M16 compound treatment 1.31348234E8 -3.39E7 -0.43 1.2574473E8 -4.16E7 -0.71 -0.8035 -0.9697 3064093 Maybridge4_003096 OC(=O)c1ccccc1SC(CC(=O)c2ccc(F)cc2)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M17 compound treatment 1.67942807E8 2710000.0 0.03 1.62753748E8 -4540000.0 -0.08 -0.031 -0.365 3178155 Maybridge4_003097 Clc1ccccc1N/C=C\C2=NN=NC2c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M18 compound treatment 1.43895733E8 -2.13E7 -0.27 1.56176739E8 -1.11E7 -0.19 -0.3239 -0.986 3064095 Maybridge4_003098 CN(C)NC(=S)NCc1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M19 compound treatment 1.35733138E8 -2.95E7 -0.37 1.30741498E8 -3.66E7 -0.63 -0.7042 -0.9686 3178156 Maybridge4_003099 CC(=O)OC1CCC2C3CC[C@H]4C[C@@H]5C[C@@H]5[C@H](O)C4(C)C3CCC12C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M20 compound treatment 1.32405516E8 -3.28E7 -0.41 1.44576788E8 -2.27E7 -0.39 -0.5662 -0.9996 1273753 Maybridge4_003100 S=C(N1CCN(Cc2ccccc2)CC1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M21 compound treatment 1.28375621E8 -3.69E7 -0.46 1.35133186E8 -3.22E7 -0.55 -0.7163 -0.9962 3064162 Maybridge4_003101 CCOC(=O)/N=C(/c1ccc(Cl)cc1)\c2cc3ccccc3cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M22 compound treatment 1.32363009E8 -3.29E7 -0.41 1.37032303E8 -3.03E7 -0.52 -0.6579 -0.9936 1623253 Maybridge4_003102 CCOC(=O)CC(Sc1ccccc1N)c2cc(OC)c(OC)c(OC)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M23 mock treatment 1.43667837E8 -2.16E7 -0.27 1.5704332E8 -1.03E7 -0.18 -0.3154 -0.9781 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 M24 mock treatment 1.45398435E8 -1.98E7 -0.25 1.42042952E8 -2.53E7 -0.43 -0.4816 -0.9656 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N01 compound treatment 1.29000241E8 -3.62E7 -0.45 1.28041243E8 -3.93E7 -0.67 -0.7966 -0.9819 3178157 Maybridge4_003103 CN(C)c1ccc(/C=C(\C#N)/c2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N02 compound treatment 1.2616218E8 -3.91E7 -0.49 1.39426206E8 -2.79E7 -0.48 -0.6839 -0.9999 3178158 Maybridge4_003104 FC(F)(F)Oc1ccc(OCc2n[nH]c(=S)o2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N03 compound treatment 1.30779023E8 -3.45E7 -0.43 1.37772389E8 -2.95E7 -0.51 -0.663 -0.997 1090055 Maybridge4_003105 CC(C)c1ccc(cc1)N2Cc3cc(ccc3N=C2)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N04 compound treatment 1.35337971E8 -2.99E7 -0.38 1.49397651E8 -1.79E7 -0.31 -0.4819 -0.995 3064190 Maybridge4_003106 FC(F)(F)Oc1ccc(OC(=O)C2=Cc3cc(Cl)ccc3OC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N05 compound treatment 1.41013149E8 -2.42E7 -0.3 1.66466879E8 -830000.0 -0.01 -0.2249 -0.7394 3178159 Maybridge4_003107 Cc1cc(Cl)ccc1NC(=N)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N06 compound treatment 1.19132727E8 -4.61E7 -0.58 1.36566473E8 -3.07E7 -0.53 -0.7809 -0.9989 3178160 Maybridge4_003108 FC(F)(F)c1cnc(NCCNC(=O)C(F)(F)Sc2ccccc2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N07 compound treatment 1.4623993E8 -1.9E7 -0.24 1.47151882E8 -2.01E7 -0.34 -0.4123 -0.9837 3064194 Maybridge4_003109 CCN(CC)C(=S)Oc1ccc(C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N08 compound treatment 1.38924598E8 -2.63E7 -0.33 1.53478186E8 -1.38E7 -0.24 -0.4006 -0.9867 3064195 Maybridge4_003110 CC(C)(C)CC(C)(C)NC(=O)c1cccc(/N=C/c2ccccc2O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N09 compound treatment 1.27900289E8 -3.73E7 -0.47 1.40981628E8 -2.63E7 -0.45 -0.6497 -0.9998 1463402 Maybridge4_003111 CCc1ccccc1NC(=S)Nc2ccc(Oc3ccc(Cl)cc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N10 compound treatment 1.33483284E8 -3.18E7 -0.4 1.49983372E8 -1.73E7 -0.3 -0.4912 -0.9894 3064198 Maybridge4_003112 Clc1ccc(SC(=S)NC2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N11 compound treatment 1.32869584E8 -3.24E7 -0.41 1.43913957E8 -2.34E7 -0.4 -0.5701 -1.0 1288025 Maybridge4_003113 Clc1ccc(cc1)C(=O)COC(=O)c2ccccc2NCc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N12 compound treatment 1.36672539E8 -2.86E7 -0.36 1.45604896E8 -2.17E7 -0.37 -0.5159 -0.9998 3064199 Maybridge4_003114 OC(=O)c1cc(O)nc2c(cccc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N13 compound treatment 1.3916323E8 -2.61E7 -0.33 1.48102898E8 -1.92E7 -0.33 -0.4636 -1.0 3178161 Maybridge4_003115 CC1CCCC(C)N1C(=S)NCCCN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N14 compound treatment 1.33832053E8 -3.14E7 -0.39 1.46683004E8 -2.06E7 -0.35 -0.5281 -0.9985 3178162 Maybridge4_003116 CCOC(=O)c1cc(nc(OC(=O)N(C)C)c1C#N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N15 compound treatment 1.40156637E8 -2.51E7 -0.31 1.51131197E8 -1.62E7 -0.28 -0.4181 -0.998 3064201 Maybridge4_003117 COc1ccc(/N=C/2\SCC(=O)N2CCc3ccc(OC)c(OC)c3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N16 compound treatment 1.34998857E8 -3.02E7 -0.38 1.53080695E8 -1.42E7 -0.24 -0.4403 -0.977 3178163 Maybridge4_003118 Clc1cn(CCC#N)cc(Cl)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N17 compound treatment 1.45251285E8 -2.0E7 -0.25 1.52652504E8 -1.46E7 -0.25 -0.3545 -1.0 3064203 Maybridge4_003119 CC1=NNC(=O)C1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N18 compound treatment 1.46489297E8 -1.87E7 -0.24 1.49009083E8 -1.83E7 -0.31 -0.3876 -0.9901 1440599 Maybridge4_003120 CCOC(=O)Cn1c(noc1=O)c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N19 compound treatment 1.35497581E8 -2.97E7 -0.37 1.54757315E8 -1.25E7 -0.21 -0.4156 -0.9655 3178164 Maybridge4_003121 Cc1cc(C)c(OC(=O)/C=C/c2cccs2)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N20 compound treatment 1.40033429E8 -2.52E7 -0.32 1.59763293E8 -7530000.0 -0.13 -0.3147 -0.9218 3064205 Maybridge4_003122 CSc1nc(NC(=O)NS(=O)(=O)c2ccccc2C(F)(F)F)nc(n1)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N21 compound treatment 1.41828809E8 -2.34E7 -0.29 1.45719712E8 -2.16E7 -0.37 -0.4688 -0.9935 1468063 Maybridge4_003123 CC(C)c1ccc(NCC(O)COc2ccc(Cl)c(Cl)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N22 compound treatment 1.44690956E8 -2.05E7 -0.26 1.45985452E8 -2.13E7 -0.36 -0.4402 -0.9855 3064206 Maybridge4_003124 O=C1CNC(=S)N1CCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N23 mock treatment 1.48044724E8 -1.72E7 -0.22 1.43910555E8 -2.34E7 -0.4 -0.4356 -0.9579 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 N24 mock treatment 1.28719789E8 -3.65E7 -0.46 1.39721624E8 -2.76E7 -0.47 -0.6577 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O01 compound treatment 1.36519136E8 -2.87E7 -0.36 1.35415433E8 -3.19E7 -0.55 -0.6406 -0.9797 1118081 Maybridge4_003125 NNC(=O)CNc1ccc2OCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O02 compound treatment 1.12816117E8 -5.24E7 -0.66 1.12618733E8 -5.47E7 -0.94 -1.1268 -0.9851 3178165 Maybridge4_003126 CCOC(=O)c1cnc(S/C=C/C(=O)c2ccc(C)cc2)nc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O03 compound treatment 1.21361896E8 -4.39E7 -0.55 1.43987312E8 -2.33E7 -0.4 -0.6713 -0.9875 1121873 Maybridge4_003127 OC(=O)c1ccccc1S(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O04 compound treatment 1.09547294E8 -5.57E7 -0.7 1.29864333E8 -3.74E7 -0.64 -0.9471 -0.9991 3064232 Maybridge4_003128 Clc1ccc(cc1)C(=O)O/C=C/C(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O05 compound treatment 1.3036746E8 -3.49E7 -0.44 1.56749648E8 -1.05E7 -0.18 -0.437 -0.9234 3178166 Maybridge4_003129 CNC(=O)c1cccc2cccc(Br)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O06 compound treatment 1.28967029E8 -3.63E7 -0.45 1.52533785E8 -1.48E7 -0.25 -0.5004 -0.9615 3178167 Maybridge4_003130 COc1ccc(cc1)C(=O)/C=C/Nc2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O07 compound treatment 1.22389415E8 -4.28E7 -0.54 1.48181365E8 -1.91E7 -0.33 -0.6114 -0.9717 3064235 Maybridge4_003131 N#CN=C(NC1CCCCC1)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O08 compound treatment 1.27530311E8 -3.77E7 -0.47 1.42365156E8 -2.49E7 -0.43 -0.6362 -0.9987 3178168 Maybridge4_003132 Fc1ccc(cc1)C(=O)/C=C/Sc2nc3cc(Cl)ccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O09 compound treatment 1.28329693E8 -3.69E7 -0.46 1.42490045E8 -2.48E7 -0.42 -0.6276 -0.9991 1715504 Maybridge4_003133 CN1C(=O)C(Cc2ccccc2)(c3ccccc13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O10 compound treatment 1.29653213E8 -3.56E7 -0.45 1.41867607E8 -2.54E7 -0.44 -0.6234 -0.9999 1565110 Maybridge4_003134 CN(C)C(=O)Oc1cc(C)n(C)c(=O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O11 compound treatment 1.39674007E8 -2.56E7 -0.32 1.34128454E8 -3.32E7 -0.57 -0.6282 -0.9634 3064240 Maybridge4_003135 C/C=C(\C(=N\O)\C)/c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O12 compound treatment 1.00232002E8 -6.5E7 -0.82 7.2044097E7 -9.53E7 -1.63 -1.7296 -0.9487 1124022 Maybridge4_003136 CC(=O)n1c(cc(c(C#N)c1=O)c2ccc(C)cc2)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O13 compound treatment 1.17258381E8 -4.8E7 -0.6 7.0464477E7 -9.68E7 -1.66 -1.5977 -0.906 1736617 Maybridge4_003137 COc1ccc(cc1)c2nc([nH]c(=O)c2C#N)N(C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O14 compound treatment 1.10450605E8 -5.48E7 -0.69 6.47766E7 -1.03E8 -1.75 -1.7269 -0.9163 3178250 Maybridge4_003138 FC(F)(F)c1ccc(/C=C(\C#N)/c2c[nH]c3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O15 compound treatment 1.33026971E8 -3.22E7 -0.4 7.3984213E7 -9.33E7 -1.6 -1.4152 -0.8589 1429244 Maybridge4_003139 CCOC(=O)Cc1c(C)[nH]c(C(=O)OCC)c1CC(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O16 compound treatment 1.30127099E8 -3.51E7 -0.44 6.9898937E7 -9.74E7 -1.67 -1.4903 -0.8642 1373405 Maybridge4_003140 CC(=O)SC1CC(=O)N(C1=O)c2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O17 compound treatment 1.30502508E8 -3.47E7 -0.44 7.7172468E7 -9.01E7 -1.54 -1.399 -0.8727 3178251 Maybridge4_003141 O=C(C/C(=C\1/Cc2ccccc2C1=O)/c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O18 compound treatment 1.36459497E8 -2.88E7 -0.36 7.7572714E7 -8.97E7 -1.54 -1.3413 -0.8501 3064242 Maybridge4_003142 CN(C)NC(=S)NCc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O19 compound treatment 1.02302081E8 -6.29E7 -0.79 7.3035594E7 -9.43E7 -1.61 -1.6992 -0.9459 3178252 Maybridge4_003143 CCOC(=O)OC1CCC2C3CCC4=CC(=O)C(=C)CC4(C)C3CCC12C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O20 compound treatment 1.45968685E8 -1.93E7 -0.24 8.9016691E7 -7.83E7 -1.34 -1.1184 -0.8214 1442612 Maybridge4_003144 Cc1cc(NCn2ncc3ccccc3c2=O)ccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O21 compound treatment 1.5492265E8 -1.03E7 -0.13 9.4804132E7 -7.25E7 -1.24 -0.9689 -0.7766 3178253 Maybridge4_003145 Brc1ccc(cc1)c2cnc(/C=C/C=C/N3CCOCC3)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O22 compound treatment 1.49427486E8 -1.58E7 -0.2 9.6953469E7 -7.03E7 -1.2 -0.9917 -0.8126 1286622 Maybridge4_003146 O=C1c2ccccc2-c3c1c4ccccc4c(=O)n3CC5CC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O23 mock treatment 1.57125386E8 -8110000.0 -0.1 1.0737885E8 -5.99E7 -1.03 -0.7972 -0.7734 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 O24 mock treatment 1.8809428E7 -1.46E8 -1.84 1.1018605E8 -5.71E7 -0.98 -1.9901 -0.9564 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P01 compound treatment 1.51240799E8 -1.4E7 -0.18 1.62005121E8 -5290000.0 -0.09 -0.1882 -0.9526 3178254 Maybridge4_003147 COc1ccc(/C=C(\C#N)/c2ccc(OC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P02 compound treatment 1.30278562E8 -3.5E7 -0.44 1.35340695E8 -3.2E7 -0.55 -0.6969 -0.994 1202102 Maybridge4_003148 COc1ccc(cc1OC)C2SC(=S)NC(=C2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P03 compound treatment 1.41536489E8 -2.37E7 -0.3 1.53681555E8 -1.36E7 -0.23 -0.375 -0.9927 3178255 Maybridge4_003149 O=C(NC(=S)N1CCCCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P04 compound treatment 1.46224439E8 -1.9E7 -0.24 1.3869365E8 -2.86E7 -0.49 -0.5149 -0.9453 3178256 Maybridge4_003150 Cc1cc(Sc2ccc(Cl)cc2)nc(n1)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P05 compound treatment 1.5104988E8 -1.42E7 -0.18 1.4974437E8 -1.76E7 -0.3 -0.3383 -0.9687 3064323 Maybridge4_003151 CCOC(=O)NC(=S)Nc1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P06 compound treatment 1.38155843E8 -2.71E7 -0.34 1.45328365E8 -2.2E7 -0.38 -0.5061 -0.9987 1496124 Maybridge4_003152 Nc1nc(Cc2ccc(F)cc2F)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P07 compound treatment 1.2167286E8 -4.36E7 -0.55 1.4552528E8 -2.18E7 -0.37 -0.6499 -0.9826 1646965 Maybridge4_003153 Oc1cc(O)n(Cc2ccco2)c(=S)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P08 compound treatment 1.43776541E8 -2.15E7 -0.27 1.45550979E8 -2.17E7 -0.37 -0.4536 -0.9873 3178257 Maybridge4_003154 COc1cc(NC(=O)C(Sc2nc(C)cc(C)c2C#N)c3ccccc3)c(OC)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P09 compound treatment 1.33066981E8 -3.22E7 -0.4 1.43625537E8 -2.37E7 -0.41 -0.5719 -1.0 1555108 Maybridge4_003155 Sc1nc2ccccc2c(=O)n1CCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P10 compound treatment 1.37775674E8 -2.75E7 -0.34 1.56248714E8 -1.1E7 -0.19 -0.3773 -0.9601 1688911 Maybridge4_003156 CN(C(=O)N(C)C(=O)c1ccccc1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P11 compound treatment 1.32651018E8 -3.26E7 -0.41 1.46824528E8 -2.05E7 -0.35 -0.5368 -0.9971 1186033 Maybridge4_003157 CCNC(=S)Nc1ccc(NC(=O)c2ccccc2O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P12 compound treatment 1.34330373E8 -3.09E7 -0.39 1.57698702E8 -9600000.0 -0.16 -0.3903 -0.927 3064360 Maybridge4_003158 CN(C)/C=N/c1nonc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P13 compound treatment 1.38422533E8 -2.68E7 -0.34 1.4767109E8 -1.96E7 -0.34 -0.4754 -1.0 3178258 Maybridge4_003159 COc1ccccc1/C=C(\C#N)/c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P14 compound treatment 1.45431149E8 -1.98E7 -0.25 1.51432387E8 -1.59E7 -0.27 -0.3677 -0.999 1641024 Maybridge4_003160 CC(C)NC(=O)Oc1noc2ccc(Cl)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P15 compound treatment 1.37806272E8 -2.74E7 -0.34 1.46442436E8 -2.09E7 -0.36 -0.4957 -0.9998 3178259 Maybridge4_003161 CS/C(=N\c1c(C)cccc1C)/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P16 compound treatment 1.33753278E8 -3.15E7 -0.39 1.36455596E8 -3.08E7 -0.53 -0.6526 -0.9898 1687023 Maybridge4_003162 CC(C)(C)C(=O)Nc1cccc(c1)c2cc(no2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P17 compound treatment 1.45592893E8 -1.96E7 -0.25 1.35017367E8 -3.23E7 -0.55 -0.565 -0.9338 3064362 Maybridge4_003163 Cc1nc(S)nc(O)c1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P18 compound treatment 1.37750073E8 -2.75E7 -0.34 1.26997144E8 -4.03E7 -0.69 -0.7316 -0.9486 1159384 Maybridge4_003164 COC(=O)c1c(NC(=O)NCc2ccccc2)onc1c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P19 compound treatment 1.47629741E8 -1.76E7 -0.22 1.26960619E8 -4.03E7 -0.69 -0.6444 -0.8889 1135236 Maybridge4_003165 Clc1ccc(cc1)C(=O)Oc2ccccc2OCC(=O)NCc3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P20 compound treatment 1.37831485E8 -2.74E7 -0.34 1.20506758E8 -4.68E7 -0.8 -0.8094 -0.9287 3178260 Maybridge4_003166 CSc1nc(NC(=O)NS(=O)(=O)Cc2ccc(Cl)cc2Cl)nc(n1)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P21 compound treatment 1.49270209E8 -1.6E7 -0.2 1.38348466E8 -2.89E7 -0.5 -0.492 -0.9205 1287410 Maybridge4_003167 CSc1nc2ccccc2c(=O)n1c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P22 compound treatment 1.48060103E8 -1.72E7 -0.22 1.29797747E8 -3.75E7 -0.64 -0.6062 -0.8954 3178261 Maybridge4_003168 COC(=O)c1ccc(nc1)C(=O)Nc2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P23 mock treatment 1.4074101E8 -2.45E7 -0.31 1.25305209E8 -4.2E7 -0.72 -0.7255 -0.9281 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2057 P24 mock treatment 1.39915221E8 -2.53E7 -0.32 1.2174463E8 -4.56E7 -0.78 -0.776 -0.9216 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A01 compound treatment 5.0035608E7 -9.87E7 -1.24 1.87469753E8 3.07E7 0.53 -0.5036 -0.3744 3064365 Maybridge4_003169 Clc1ccccc1CN2C(=O)CNC2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A02 compound treatment 9.4701231E7 -5.4E7 -0.68 1.95778864E8 3.9E7 0.67 -0.0069 -0.0072 3178262 Maybridge4_003170 Cc1cc(SCC(=O)NN)c(C)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A03 compound treatment 1.06033838E8 -4.27E7 -0.54 1.93938023E8 3.72E7 0.64 0.0714 0.0858 1123055 Maybridge4_003171 Clc1ccccc1OCCN2C(=O)CNC2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A04 compound treatment 1.13815644E8 -3.49E7 -0.44 1.86121911E8 2.94E7 0.5 0.0458 0.0687 3178263 Maybridge4_003172 CC(=O)N1c2ccccc2C=Cc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A05 compound treatment 1.51777203E8 3030000.0 0.04 2.03243092E8 4.65E7 0.8 0.5898 0.7401 3178264 Maybridge4_003173 COc1nc(NC(=O)NS(=O)(=O)Nc2cccc3cccnc23)nc(OC)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A06 compound treatment 1.47493385E8 -1250000.0 -0.02 1.85891011E8 2.91E7 0.5 0.3417 0.6846 1697760 Maybridge4_003174 S=C(NC1CC2CC1C=C2)Nc3ccc4[nH]ccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A07 compound treatment 1.59101906E8 1.04E7 0.13 2.00523071E8 4.38E7 0.75 0.6218 0.8175 3064405 Maybridge4_003175 CNc1nc2c(Cl)cc(Cl)cc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A08 compound treatment 1.67066006E8 1.83E7 0.23 1.88426346E8 3.17E7 0.54 0.546 0.927 3064407 Maybridge4_003176 CC(C)OC(=S)Nc1cccc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A09 compound treatment 1.58373044E8 9630000.0 0.12 1.8055153E8 2.38E7 0.41 0.3736 0.8789 3178265 Maybridge4_003177 CCN(C(=O)c1cnccc1C(F)(F)F)c2c(C)cccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A10 compound treatment 1.56177495E8 7440000.0 0.09 1.60279283E8 3540000.0 0.06 0.1088 0.9781 1316937 Maybridge4_003178 Cc1ccc(C)c(COc2ccc(C)nc2NC(=S)NCc3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A11 compound treatment 1.55573744E8 6830000.0 0.09 1.55360446E8 -1380000.0 -0.02 0.0439 0.4935 3064408 Maybridge4_003179 CC1(C)ONC(=O)N(C1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A12 compound treatment 1.44081672E8 -4660000.0 -0.06 1.41133952E8 -1.56E7 -0.27 -0.2303 -0.8419 1490878 Maybridge4_003180 COc1ccccc1C2CCN(CC2)C(=O)c3cccnc3Sc4ccc(C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A13 compound treatment 1.46392664E8 -2350000.0 -0.03 1.40060718E8 -1.67E7 -0.29 -0.2228 -0.776 3064412 Maybridge4_003181 FC(F)(F)c1cccc(c1)n2c(noc2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A14 compound treatment 1.50204224E8 1460000.0 0.02 1.53232267E8 -3510000.0 -0.06 -0.0295 -0.4699 1158023 Maybridge4_003182 Sc1nnc(CSCc2cccc3ccccc23)n1C4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A15 compound treatment 1.44133023E8 -4610000.0 -0.06 1.36926541E8 -1.98E7 -0.34 -0.2807 -0.8159 3064413 Maybridge4_003183 Brc1ccc(cc1)C(=O)CSc2nc(c3cccs3)c(C#N)c(=O)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A16 compound treatment 1.51569547E8 2830000.0 0.04 1.4237043E8 -1.44E7 -0.25 -0.1489 -0.599 1059941 Maybridge4_003184 OC(=O)c1cc2cc(Cl)ccc2oc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A17 compound treatment 1.45529032E8 -3210000.0 -0.04 1.39193871E8 -1.75E7 -0.3 -0.2409 -0.7949 3178266 Maybridge4_003185 Cc1cc(C)cc(Sc2ccc3nnc(c4ccccc4)n3n2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A18 compound treatment 1.5775265E8 9010000.0 0.11 1.42055709E8 -1.47E7 -0.25 -0.0978 -0.355 3178267 Maybridge4_003186 CC(C)c1ccc(/C=C/2\CSc3ccccc3C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A19 compound treatment 1.67478787E8 1.87E7 0.24 1.39083567E8 -1.77E7 -0.3 -0.0475 -0.1242 3064415 Maybridge4_003187 Cc1cc(Cc2ccc(Cl)cc2)c(=O)[nH]n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A20 compound treatment 1.67212334E8 1.85E7 0.23 1.48626331E8 -8120000.0 -0.14 0.0656 0.2428 3178268 Maybridge4_003188 O=C(/C=C\1/Nc2ccccc2OC1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A21 compound treatment 1.68957617E8 2.02E7 0.25 1.45749711E8 -1.1E7 -0.19 0.0463 0.1465 3064418 Maybridge4_003189 CCOC(=O)CSc1nc2cccnc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A22 compound treatment 1.71624548E8 2.29E7 0.29 1.45271779E8 -1.15E7 -0.2 0.0641 0.1844 3178269 Maybridge4_003190 COc1ccc(cc1)C2=Nc3ccccc3SC(C2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A23 mock treatment 1.69113372E8 2.04E7 0.26 1.55881065E8 -861000.0 -0.01 0.1703 0.6652 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 A24 mock treatment 1.76283024E8 2.75E7 0.35 1.51756716E8 -4990000.0 -0.09 0.1839 0.5169 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B01 compound treatment 1.63171764E8 1.44E7 0.18 1.46116052E8 -1.06E7 -0.18 -6.0E-4 -0.0025 1225177 Maybridge4_003191 CCOC(=O)c1c(C)c(=O)oc2n(nc(O)c12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B02 compound treatment 2.03643171E8 5.49E7 0.69 1.59131826E8 2390000.0 0.04 0.5159 0.7478 1739696 Maybridge4_003192 O=C1N(Cc2ccccc2)S(=O)(=O)c3ccccc3S(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B03 compound treatment 2.14913204E8 6.62E7 0.83 1.8078763E8 2.4E7 0.41 0.878 0.9476 3064449 Maybridge4_003193 CC(=O)OC[C@H]1O[C@@H](NC(=O)N)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B04 compound treatment 2.09786351E8 6.1E7 0.77 1.72754087E8 1.6E7 0.27 0.7353 0.904 2101805 Maybridge4_003194 CCC(=O)NC(Nc1ccc(O)cc1)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B05 compound treatment 2.34375281E8 8.56E7 1.07 1.73890269E8 1.71E7 0.29 0.9672 0.8685 1443369 Maybridge4_003195 CCc1ccc2oc3nc(N)c(C#N)cc3c(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B06 compound treatment 2.20863173E8 7.21E7 0.9 1.94975095E8 3.82E7 0.65 1.1025 0.9874 1585673 Maybridge4_003196 CCOC(=O)CCc1ccc(OCc2ccccc2)c(I)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B07 compound treatment 2.11414601E8 6.27E7 0.79 1.83942996E8 2.72E7 0.47 0.8852 0.9687 3064452 Maybridge4_003197 CC(=O)OC[C@H]1OC[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@H]1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B08 compound treatment 2.16570539E8 6.78E7 0.85 1.79762396E8 2.3E7 0.39 0.8803 0.9388 3178366 Maybridge4_003198 CC1(C)c2ccccc2N3CC(=O)NC31/C=C/c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B09 compound treatment 2.11994499E8 6.33E7 0.79 1.18552518E8 -3.82E7 -0.65 0.0988 0.0961 1005564 Maybridge4_003199 CC(=O)Nc1ccc(cc1)c2ccc(NC(=O)C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B10 compound treatment 2.11549093E8 6.28E7 0.79 1.12403631E8 -4.43E7 -0.76 0.0204 0.0187 3178367 Maybridge4_003200 Cc1nn(c(O)c1Cc2c(Cl)cccc2Cl)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B11 compound treatment 2.06065442E8 5.73E7 0.72 1.66388489E8 9650000.0 0.17 0.6252 0.8474 1167085 Maybridge4_003201 COc1ccc(CC2CCc3ncc(C)cc3C2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B12 compound treatment 1.99011011E8 5.03E7 0.63 1.10790505E8 -4.6E7 -0.79 -0.1103 -0.1094 3178368 Maybridge4_003202 N/N=C(/Cn1nnc(n1)N2CCCCC2)\c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B13 compound treatment 2.12591404E8 6.38E7 0.8 1.87110901E8 3.04E7 0.52 0.9339 0.9781 3064453 Maybridge4_003203 S=c1sc2ccccc2n1CCn3c(=S)sc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B14 compound treatment 2.07774355E8 5.9E7 0.74 1.76997924E8 2.03E7 0.35 0.7688 0.9402 1238987 Maybridge4_003204 CCCc1c(C)nc(SCC(=O)C(C)(C)C)nc1OC(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B15 compound treatment 2.26132264E8 7.74E7 0.97 1.24871191E8 -3.19E7 -0.55 0.3007 0.27 3178369 Maybridge4_003205 CC1CN=C(S1)N(CCc2ccccc2)C(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B16 compound treatment 2.06112008E8 5.74E7 0.72 1.07613849E8 -4.91E7 -0.84 -0.0858 -0.0775 1004236 Maybridge4_003206 Cc1ccccc1NC(=N)NC(=N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B17 compound treatment 2.15121609E8 6.64E7 0.83 1.17137058E8 -3.96E7 -0.68 0.1094 0.1019 1381247 Maybridge4_003207 Sc1nnc(CCCc2nnc(S)o2)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B18 compound treatment 1.85997724E8 3.73E7 0.47 1.55482969E8 -1260000.0 -0.02 0.3152 0.6738 1184925 Maybridge4_003208 CN(C)C(=O)Oc1nc(SCC(=O)c2ccc(Cl)cc2)nc(C)c1CC(=C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B19 compound treatment 2.04192805E8 5.55E7 0.7 1.49784283E8 -6960000.0 -0.12 0.4076 0.5776 3064457 Maybridge4_003209 COc1ccccc1C2CCN(CCCOc3ccc(Cl)cc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B20 compound treatment 1.93459848E8 4.47E7 0.56 1.73993066E8 1.73E7 0.3 0.6055 0.9551 3178370 Maybridge4_003210 CCNC(=S)NCC1CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B21 compound treatment 1.02930381E8 -4.58E7 -0.57 7.4987845E7 -8.18E7 -1.4 -1.3959 -0.9227 1489027 Maybridge4_003211 Oc1c(Cl)c(=O)n(Cc2ccccc2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B22 compound treatment 1.73408599E8 2.47E7 0.31 1.52024662E8 -4720000.0 -0.08 0.1617 0.5056 1250091 Maybridge4_003212 O=C(Nc1ccc(cc1)S(=O)(=O)NC2(CC3CC4CC(C3)C2)C4)C5CC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B23 mock treatment 1.8496717E8 3.62E7 0.45 1.58894675E8 2150000.0 0.04 0.3474 0.7619 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 B24 mock treatment 1.75223277E8 2.65E7 0.33 1.60554151E8 3810000.0 0.07 0.281 0.8301 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C01 compound treatment 4.959924E7 -9.91E7 -1.24 1.3240365E8 -2.43E7 -0.42 -1.174 -0.8951 3064501 Maybridge4_003213 O=C(Nc1ccccc1)Nc2ccc3nnsc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C02 compound treatment 1.05512529E8 -4.32E7 -0.54 1.7091119E8 1.42E7 0.24 -0.212 -0.3568 1507422 Maybridge4_003214 CC(C)(C)c1ccc(OCC(=O)n2ncc(C#N)c2N)c(c1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C03 compound treatment 9.106477E7 -5.77E7 -0.72 1.65386756E8 8640000.0 0.15 -0.407 -0.5511 1402640 Maybridge4_003215 COc1ccc(OCCN2C(=O)CNC2=S)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C04 compound treatment 1.06476842E8 -4.23E7 -0.53 1.5521786E8 -1520000.0 -0.03 -0.3934 -0.741 1499674 Maybridge4_003216 Cc1ccc2N(CCCc2c1)C(=O)CC(=O)N3CCCc4cc(C)ccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C05 compound treatment 1.21988952E8 -2.68E7 -0.34 1.4107003E8 -1.57E7 -0.27 -0.427 -0.9938 3064504 Maybridge4_003217 CC(C)c1ccc(NC(=S)Sc2ccc(F)cc2F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C06 compound treatment 1.29049672E8 -1.97E7 -0.25 1.52779904E8 -3960000.0 -0.07 -0.2226 -0.8691 1213648 Maybridge4_003218 Cc1ccc(CC(=S)N2CCOCC2)cn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C07 compound treatment 1.32656457E8 -1.61E7 -0.2 1.52302959E8 -4440000.0 -0.08 -0.1964 -0.9109 3178371 Maybridge4_003219 CCN(C(=O)c1cnccc1C(F)(F)F)c2nc3cc(Cl)ccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C08 compound treatment 1.33002461E8 -1.57E7 -0.2 1.56137785E8 -605000.0 -0.01 -0.1469 -0.7431 1153252 Maybridge4_003220 COc1cc2cc(OCc3c(F)cccc3Cl)nc(C)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C09 compound treatment 1.26887561E8 -2.19E7 -0.27 1.57150339E8 408000.0 0.01 -0.1889 -0.6889 3178372 Maybridge4_003221 CSc1cc(c(cn1)C(=O)Nc2c(C)cccc2C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C10 compound treatment 8.3720542E7 -6.5E7 -0.82 9.7250044E7 -5.95E7 -1.02 -1.2969 -0.9939 3064507 Maybridge4_003222 CCC/N=c/1\ssc(=O)n1CCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C11 compound treatment 1.29599111E8 -1.91E7 -0.24 1.48102951E8 -8640000.0 -0.15 -0.2744 -0.9729 3178373 Maybridge4_003223 COc1nccc(c1C(=O)NC(=O)Nc2c(C)cccc2C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C12 compound treatment 1.35671778E8 -1.31E7 -0.16 1.54116592E8 -2630000.0 -0.04 -0.1477 -0.8689 3064509 Maybridge4_003224 FC(F)(F)c1ccc(NC(=O)CSCc2cccc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C13 compound treatment 1.36641786E8 -1.21E7 -0.15 1.4467987E8 -1.21E7 -0.21 -0.2533 -0.9885 1304317 Maybridge4_003225 Clc1cccc(c1)c2noc(=O)n2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C14 compound treatment 1.32943189E8 -1.58E7 -0.2 1.42217994E8 -1.45E7 -0.25 -0.316 -0.9937 1154699 Maybridge4_003226 CC(C)COC(=O)c1cn(C2CCCCC2)c3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C15 compound treatment 1.46265707E8 -2480000.0 -0.03 1.52214097E8 -4530000.0 -0.08 -0.0768 -0.9194 1407275 Maybridge4_003227 COC(=O)C1c2ccccc2Oc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C16 compound treatment 1.52199831E8 3460000.0 0.04 1.52187205E8 -4560000.0 -0.08 -0.0245 -0.2742 1661086 Maybridge4_003228 COc1ccc(CC2C(=O)OC(C)(C)OC2=O)c(Cl)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C17 compound treatment 1.48432312E8 -310000.0 0.0 1.40591939E8 -1.62E7 -0.28 -0.1982 -0.717 3178374 Maybridge4_003229 CC1=C(Sc2ccccc2N1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C18 compound treatment 1.41640224E8 -7100000.0 -0.09 1.43908473E8 -1.28E7 -0.22 -0.2183 -0.921 3064548 Maybridge4_003230 O=C1/C(=C/c2c[nH]c3ccccc23)/CSc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C19 compound treatment 1.51444287E8 2700000.0 0.03 1.49953923E8 -6790000.0 -0.12 -0.0582 -0.4808 3178375 Maybridge4_003231 Cc1cc(Cc2cccs2)c(=O)[nH]n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C20 compound treatment 1.49279315E8 537000.0 0.01 1.45569111E8 -1.12E7 -0.19 -0.1305 -0.6818 1550561 Maybridge4_003232 OC(COc1ccc(F)cc1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C21 compound treatment 1.44838265E8 -3900000.0 -0.05 1.40928634E8 -1.58E7 -0.27 -0.226 -0.8217 1029711 Maybridge4_003233 CCOC(=O)c1cc(=O)c2ccc(OCc3ccccc3)cc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C22 compound treatment 1.31075509E8 -1.77E7 -0.22 1.29179159E8 -2.76E7 -0.47 -0.4903 -0.9406 3178376 Maybridge4_003234 Oc1ccc(cc1)C2CC(=Nc3ccccc3S2)c4ccccc4O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C23 mock treatment 1.49561034E8 819000.0 0.01 1.48156451E8 -8590000.0 -0.15 -0.0967 -0.6561 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 C24 mock treatment 1.48229858E8 -513000.0 -0.01 1.53718027E8 -3020000.0 -0.05 -0.0412 -0.7889 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D01 compound treatment 1.52409102E8 3670000.0 0.05 1.52856874E8 -3890000.0 -0.07 -0.0145 -0.1794 1653141 Maybridge4_003235 Nc1cc(=O)[nH]c(=O)n1c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D02 compound treatment 1.61687721E8 1.29E7 0.16 1.53326993E8 -3420000.0 -0.06 0.0735 0.4258 3178377 Maybridge4_003236 CNS(=O)(=O)c1ccc(cc1S(=O)c2ccccc2C(=O)O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D03 compound treatment 1.58763279E8 1.0E7 0.13 1.67385909E8 1.06E7 0.18 0.2177 0.9836 1915933 Maybridge4_003237 COC(=O)Nc1nc2cc(ccc2[nH]1)c3n[nH]c(=O)c4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D04 compound treatment 1.60306273E8 1.16E7 0.15 1.56368425E8 -374000.0 -0.01 0.098 0.6752 1252966 Maybridge4_003238 Oc1c(c2ccccc2)c(=O)[nH]c3ccc(F)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D05 compound treatment 1.71140075E8 2.24E7 0.28 1.58560545E8 1820000.0 0.03 0.2207 0.7807 3178378 Maybridge4_003239 Brc1ccc(cc1)C(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D06 compound treatment 1.47433304E8 -1310000.0 -0.02 1.46153885E8 -1.06E7 -0.18 -0.1398 -0.768 3064551 Maybridge4_003240 CCN1C(=O)N(CC)C(=O)C(=Cc2c(O)n(CC)c(=O)n(CC)c2=O)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D07 compound treatment 1.62901423E8 1.42E7 0.18 1.56747095E8 4710.0 0.0 0.1257 0.7074 3178379 Maybridge4_003241 CC(=O)O[C@@H]1CO[C@@H]([C@@H](OC(=O)C)[C@@H]1OC(=O)C)c2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D08 compound treatment 1.56558544E8 7820000.0 0.1 1.1913967E8 -3.76E7 -0.64 -0.3858 -0.5926 3178380 Maybridge4_003242 CC1(C)c2ccccc2N3CC(=O)NC31/C=C/c4ccc(cc4)N5CCOCC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D09 compound treatment 1.58576499E8 9830000.0 0.12 1.19030445E8 -3.77E7 -0.65 -0.3692 -0.5618 1190502 Maybridge4_003243 Clc1ccc2n(CN3CCCCC3)c4ccc(Cl)cc4c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D10 compound treatment 1.57828512E8 9090000.0 0.11 1.53606484E8 -3140000.0 -0.05 0.0426 0.3384 3064581 Maybridge4_003244 CNC(=S)Nc1cc(Cl)cc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D11 compound treatment 1.49575807E8 833000.0 0.01 1.51785025E8 -4960000.0 -0.08 -0.0526 -0.6153 1208488 Maybridge4_003245 OC(=O)CCC1CCCCCCCCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D12 compound treatment 1.52770805E8 4030000.0 0.05 1.53471391E8 -3270000.0 -0.06 -0.0039 -0.0512 3064582 Maybridge4_003246 O/N=C(/Cn1nnc(n1)N2CCCC2)\c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D13 compound treatment 1.64768238E8 1.6E7 0.2 1.73865113E8 1.71E7 0.29 0.3494 0.9831 3064584 Maybridge4_003247 C([n+]1ccccc1)[n+]2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D14 compound treatment 1.62250726E8 1.35E7 0.17 1.64684014E8 7940000.0 0.14 0.216 0.994 3178381 Maybridge4_003248 Cc1nc(SCC(=O)C(C)(C)C)nc(O)c1Cc2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D15 compound treatment 1.61358697E8 1.26E7 0.16 1.62412906E8 5670000.0 0.1 0.1805 0.9725 3178382 Maybridge4_003249 CC(N(C(=O)Nc1ccc(Cl)cc1)C2=NCC(C)S2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D16 compound treatment 1.51492346E8 2750000.0 0.03 1.47904954E8 -8840000.0 -0.15 -0.0826 -0.5322 3064586 Maybridge4_003250 CC(C)(C)c1cs/c(=N\c2ccc(F)cc2F)/o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D17 compound treatment 1.49540673E8 798000.0 0.01 1.56901202E8 159000.0 0.0 0.009 0.8677 3178383 Maybridge4_003251 C(CCc1nnc(SCc2ccccc2)o1)Cc3nnc(SCc4ccccc4)o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D18 compound treatment 1.46719566E8 -2020000.0 -0.03 1.50182508E8 -6560000.0 -0.11 -0.0973 -0.8456 3064589 Maybridge4_003252 FC(F)(F)c1ccc(Cl)c(Nc2ncnc(n2)n3cccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D19 compound treatment 1.52468028E8 3730000.0 0.05 1.20761255E8 -3.6E7 -0.62 -0.4025 -0.6516 1521138 Maybridge4_003253 COc1ccc(CCNC(=O)C2CCCCC2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D20 compound treatment 1.58374713E8 9630000.0 0.12 1.67137128E8 1.04E7 0.18 0.2113 0.9822 2078178 Maybridge4_003254 CC(C)[n+]1c(C)csc1Nc2ccc(F)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D21 compound treatment 1.50137391E8 1390000.0 0.02 1.58385421E8 1640000.0 0.03 0.0323 0.9739 1308049 Maybridge4_003255 O=c1cc(NCc2ccccc2)[nH]nc1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D22 compound treatment 1.65806213E8 1.71E7 0.21 1.67171499E8 1.04E7 0.18 0.2776 0.9959 3178478 Maybridge4_003256 CCCC1=NNC(=O)C1Cc2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D23 mock treatment 1.47520456E8 -1220000.0 -0.02 1.47376906E8 -9370000.0 -0.16 -0.1242 -0.7712 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 D24 mock treatment 1.39431438E8 -9310000.0 -0.12 1.47008943E8 -9730000.0 -0.17 -0.2004 -0.9849 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E01 compound treatment 6.387842E7 -8.49E7 -1.06 1.4953383E8 -7210000.0 -0.12 -0.84 -0.7838 3064592 Maybridge4_003257 CSC1=NCC(=O)N1Cc2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E02 compound treatment 1.00010139E8 -4.87E7 -0.61 1.2995091E8 -2.68E7 -0.46 -0.7566 -0.99 1522772 Maybridge4_003258 CCCCc1cc(C)c2ncc(C(=O)O)c(O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E03 compound treatment 1.13099434E8 -3.56E7 -0.45 1.38357344E8 -1.84E7 -0.31 -0.5387 -0.9852 1340715 Maybridge4_003259 CC(C)NC(=O)N(Cc1cccs1)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E04 compound treatment 1.57433087E8 8690000.0 0.11 1.44635227E8 -1.21E7 -0.21 -0.0695 -0.2966 1280280 Maybridge4_003260 Oc1c(c2ccccc2)c(=O)n3c4ccccc4c5cccc1c53 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E05 compound treatment 1.73260543E8 2.45E7 0.31 1.45103382E8 -1.16E7 -0.2 0.0766 0.209 3178479 Maybridge4_003261 COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc2nc(C)c3CS(=O)(=O)CCc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E06 compound treatment 1.79946886E8 3.12E7 0.39 1.39195114E8 -1.75E7 -0.3 0.0644 0.1305 1428973 Maybridge4_003262 COC(=O)C1=C(C)NC(=O)CC1c2ccccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E07 compound treatment 1.93635857E8 4.49E7 0.56 1.57900738E8 1160000.0 0.02 0.4122 0.7316 3178480 Maybridge4_003263 CSc1nc(nc(N)c1C#N)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E08 compound treatment 1.92130387E8 4.34E7 0.54 1.37922938E8 -1.88E7 -0.32 0.1571 0.2483 1476870 Maybridge4_003264 COc1ccc2n(C3CC3)c(C)c(C(=O)ON4C(=O)CCC4=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E09 compound treatment 1.79652521E8 3.09E7 0.39 1.42387359E8 -1.44E7 -0.25 0.1004 0.2188 3178481 Maybridge4_003265 Cc1cccc(C)c1NC(=O)c2cnc(NC3CCCCC3)cc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E10 compound treatment 1.86018837E8 3.73E7 0.47 1.48065959E8 -8680000.0 -0.15 0.2256 0.4599 3063905 Maybridge4_003266 FC(F)(F)c1cc(Cl)c2ncc(nc2c1)c3ccc(Br)s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E11 compound treatment 1.8894004E8 4.02E7 0.5 1.44482498E8 -1.23E7 -0.21 0.2082 0.3811 3178482 Maybridge4_003267 FC(F)(F)c1ccc(nc1)S(=O)(=O)/C(=C/c2ccsc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E12 compound treatment 1.83486665E8 3.47E7 0.44 1.56179595E8 -563000.0 -0.01 0.3014 0.6913 1329285 Maybridge4_003268 CC(C)C1CCC(C)CC1NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E13 compound treatment 1.86149139E8 3.74E7 0.47 1.41065455E8 -1.57E7 -0.27 0.1421 0.2628 3063910 Maybridge4_003269 COc1ccccc1c2nn(c3cccc(n3)C(F)(F)F)c(=O)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E14 compound treatment 1.78053476E8 2.93E7 0.37 1.61152555E8 4410000.0 0.08 0.3134 0.8349 1482860 Maybridge4_003270 COc1ccc(Oc2ncccc2NC(=O)c3ccc(OC)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E15 compound treatment 1.79387724E8 3.06E7 0.38 1.52464283E8 -4280000.0 -0.07 0.2201 0.5623 1317058 Maybridge4_003271 COc1ccc(CNc2nc(c3cccs3)c(C#N)c(=O)n2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E16 compound treatment 1.77798761E8 2.91E7 0.36 1.62083115E8 5340000.0 0.09 0.3224 0.8579 3063941 Maybridge4_003272 Cc1n[nH]c(=S)n1/N=C\c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E17 compound treatment 1.5189355E8 3150000.0 0.04 1.3653131E8 -2.02E7 -0.35 -0.2167 -0.6223 1597311 Maybridge4_003273 CCOC(CNc1ccc2nnc(c3ccccc3)n2n1)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E18 compound treatment 1.60471123E8 1.17E7 0.15 1.55317072E8 -1430000.0 -0.02 0.0868 0.5819 3063945 Maybridge4_003274 O=C1/C(=C\c2c[nH]c3ccccc23)/C(Oc4ccccc14)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E19 compound treatment 1.63420088E8 1.47E7 0.18 1.46944007E8 -9800000.0 -0.17 0.0116 0.0466 3178483 Maybridge4_003275 Cc1cc(Cc2ccc(cc2)C(F)(F)F)c(=O)[nH]n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E20 compound treatment 1.62629949E8 1.39E7 0.17 1.64268436E8 7530000.0 0.13 0.2143 0.989 1460994 Maybridge4_003276 CN(C)CCC(O)(CCc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E21 compound treatment 1.50852415E8 2110000.0 0.03 1.35238291E8 -2.15E7 -0.37 -0.2416 -0.6546 3063949 Maybridge4_003277 CN(C)/C=N/c1nnc(Sc2ccnc3cc(Cl)ccc23)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E22 compound treatment 1.64215213E8 1.55E7 0.19 1.38364369E8 -1.84E7 -0.31 -0.0852 -0.2305 1708827 Maybridge4_003278 CCOC(=O)COc1ccc(cc1)C2=Nc3ccccc3NC(C2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E23 mock treatment 1.69994243E8 2.13E7 0.27 1.37233439E8 -1.95E7 -0.33 -0.0476 -0.1115 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 E24 mock treatment 1.49383933E8 642000.0 0.01 1.36954822E8 -1.98E7 -0.34 -0.2338 -0.6901 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F01 compound treatment 1.43480852E8 -5260000.0 -0.07 1.51985404E8 -4760000.0 -0.08 -0.1043 -0.9946 3063951 Maybridge4_003279 Brc1ccc(cc1)C(=O)C2C(=O)OC(=CC2=O)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F02 compound treatment 1.32794859E8 -1.59E7 -0.2 1.57352928E8 611000.0 0.01 -0.1341 -0.6693 1535413 Maybridge4_003280 CN1CCN(CCN2C(=O)c3ccccc3Sc4cc(Cl)ccc4S2(=O)=O)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F03 compound treatment 1.47629619E8 -1110000.0 -0.01 9.8387714E7 -5.84E7 -1.0 -0.7162 -0.7169 1134402 Maybridge4_003281 O=S(=O)(N(CCC#N)C1CCCCC1)c2cccc3nsnc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F04 compound treatment 1.39883484E8 -8860000.0 -0.11 1.34973497E8 -2.18E7 -0.37 -0.3421 -0.8797 3178484 Maybridge4_003282 Cc1ccccc1/C=C/c2c[nH]c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F05 compound treatment 1.63810723E8 1.51E7 0.19 1.13401561E8 -4.33E7 -0.74 -0.3909 -0.5106 3063955 Maybridge4_003283 OC(=O)c1ccc(cc1C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F06 compound treatment 1.6196316E8 1.32E7 0.17 1.60987299E8 4240000.0 0.07 0.1687 0.9314 1062519 Maybridge4_003284 O=C(C1CCCCC1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F07 compound treatment 1.49691071E8 949000.0 0.01 1.56266805E8 -476000.0 -0.01 0.0027 0.1844 3178485 Maybridge4_003285 O=C(OC[C@H]1O[C@@H](C#N)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F08 compound treatment 1.382676E8 -1.05E7 -0.13 1.29164683E8 -2.76E7 -0.47 -0.4267 -0.8708 1658235 Maybridge4_003286 CC1(C)c2ccccc2N(CCC(=O)N)C31Oc4ccc5ccccc5c4C=C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F09 compound treatment 1.37725288E8 -1.1E7 -0.14 9.550151E7 -6.12E7 -1.05 -0.839 -0.7935 1416171 Maybridge4_003287 OC(CN1CCNCC1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F10 compound treatment 1.45005673E8 -3740000.0 -0.05 1.51125053E8 -5620000.0 -0.1 -0.1011 -0.9455 1438412 Maybridge4_003288 O=C(Cn1nnc(n1)N2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F11 compound treatment 1.50280848E8 1540000.0 0.02 1.51805192E8 -4940000.0 -0.08 -0.0461 -0.5319 3178486 Maybridge4_003289 COc1cc(COC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)cc(OC)c1.C1CCC(CC1)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F12 compound treatment 1.56567399E8 7820000.0 0.1 8.6752435E7 -7.0E7 -1.2 -0.7778 -0.647 1614817 Maybridge4_003290 COc1ccc(CCNC(=S)NC2CC2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F13 compound treatment 1.46467396E8 -2280000.0 -0.03 1.03264135E8 -5.35E7 -0.92 -0.6675 -0.7288 3178487 Maybridge4_003291 CCN1/C(=C\C(=S)Nc2ccccc2)/Sc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F14 compound treatment 1.65123838E8 1.64E7 0.21 1.44117478E8 -1.26E7 -0.22 -0.0075 -0.0252 1593331 Maybridge4_003292 CC(C)(C)C(=O)Cn1nnc(n1)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F15 compound treatment 1.55749546E8 7010000.0 0.09 1.51348477E8 -5390000.0 -0.09 -0.0031 -0.0246 3063998 Maybridge4_003293 CC1=[N+](C)c2cc(ccc2C1(C)C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F16 compound treatment 1.54504563E8 5760000.0 0.07 1.46058657E8 -1.07E7 -0.18 -0.0782 -0.3977 3178488 Maybridge4_003294 Fc1ccc(NC(=S)Nc2cc(ccc2N3CCCC3)C(F)(F)F)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F17 compound treatment 1.60070968E8 1.13E7 0.14 1.058558E8 -5.09E7 -0.87 -0.5155 -0.584 1142281 Maybridge4_003295 CN1C(=C(C(NC1=O)c2ccccc2)C(=O)OCc3ccccc3)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F18 compound treatment 1.61717617E8 1.3E7 0.16 1.68922987E8 1.22E7 0.21 0.2625 0.9925 1704243 Maybridge4_003296 COCc1cc(O)n2nc(Nc3cc(Cl)ccc3C)nc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F19 compound treatment 1.44104683E8 -4640000.0 -0.06 9.0180407E7 -6.66E7 -1.14 -0.8468 -0.7422 1313602 Maybridge4_003297 O=c1cc(NCc2ccccc2)n(c3ccccc3)c(=O)n1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F20 compound treatment 1.52813993E8 4070000.0 0.05 1.20224818E8 -3.65E7 -0.63 -0.4059 -0.6472 1473392 Maybridge4_003298 CCN(CC)C(=O)Sc1nc2ccccc2c(=O)n1CC3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F21 compound treatment 1.5195358E8 3210000.0 0.04 8.8435244E7 -6.83E7 -1.17 -0.7983 -0.6823 1547311 Maybridge4_003299 OC(=O)C1(C2C3C14)C5C2CCC3C45C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F22 compound treatment 2.0446328E8 5.57E7 0.7 2.15446268E8 5.87E7 1.0 1.2048 0.9843 3064002 Maybridge4_003300 CCCc1cc(=O)oc2cc(OC(=O)/C=C/c3cccs3)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F23 mock treatment 1.50816632E8 2070000.0 0.03 1.53108414E8 -3630000.0 -0.06 -0.0256 -0.3795 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 F24 mock treatment 1.48605818E8 -137000.0 0.0 1.34582876E8 -2.22E7 -0.38 -0.2694 -0.7103 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G01 compound treatment 4.1195594E7 -1.08E8 -1.35 1.42909444E8 -1.38E7 -0.24 -1.1214 -0.8187 1507436 Maybridge4_003301 Cc1cc(no1)N(Cc2cccc(Cl)c2Cl)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G02 compound treatment 8.5105024E7 -6.36E7 -0.8 1.51358969E8 -5380000.0 -0.09 -0.6296 -0.7835 1593004 Maybridge4_003302 O=c1ccc(n[nH]1)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G03 compound treatment 9.6158816E7 -5.26E7 -0.66 1.48532488E8 -8210000.0 -0.14 -0.5658 -0.8389 3178489 Maybridge4_003303 CSC1=N/C(=C\c2ccccc2Cl)/C(=O)N1N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G04 compound treatment 1.49777908E8 1040000.0 0.01 1.45511503E8 -1.12E7 -0.19 -0.1268 -0.6578 3178490 Maybridge4_003304 COc1ccc(C/N=C(\C)/c2c(O)c3ccccc3n(C)c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G05 compound treatment 2.11149921E8 6.24E7 0.78 1.61349083E8 4610000.0 0.08 0.6093 0.7744 3064042 Maybridge4_003305 CCN(C(=O)c1cnccc1C(F)(F)F)c2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G06 compound treatment 2.20442142E8 7.17E7 0.9 1.67589656E8 1.08E7 0.19 0.7673 0.8355 1261792 Maybridge4_003306 Cc1ccc(Oc2ncccc2NC(=O)C(=S)NCc3ccccc3)c4CCCc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G07 compound treatment 2.30209001E8 8.15E7 1.02 1.721088E8 1.54E7 0.26 0.9086 0.861 3064045 Maybridge4_003307 Cc1nc(c2nnc(o2)c3ccccc3)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G08 compound treatment 2.3143044E8 8.27E7 1.04 1.69468025E8 1.27E7 0.22 0.8875 0.8373 3178491 Maybridge4_003308 COc1ccc(cc1OC2CCCC2)C3CC(=O)NN3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G09 compound treatment 2.22190311E8 7.34E7 0.92 1.61261232E8 4520000.0 0.08 0.7062 0.7638 3064046 Maybridge4_003309 CNC(=O)NC(=O)c1cnccc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G10 compound treatment 2.08916032E8 6.02E7 0.75 1.72209933E8 1.55E7 0.26 0.721 0.9013 1193128 Maybridge4_003310 Cc1c(OCc2ccc(Cl)cc2Cl)ccc3C(=O)CC(C)(C)Oc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G11 compound treatment 1.90816096E8 4.21E7 0.53 1.61697412E8 4960000.0 0.08 0.4332 0.8103 3064048 Maybridge4_003311 COC(=O)c1cnc(Oc2c(Cl)cc(N)cc2Cl)cc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G12 compound treatment 1.7432799E8 2.56E7 0.32 1.7165466E8 1.49E7 0.26 0.4075 0.9936 1126959 Maybridge4_003312 COc1ccccc1C2CCN(CC2)C(=O)CSCc3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G13 compound treatment 1.66364307E8 1.76E7 0.22 1.5532913E8 -1410000.0 -0.02 0.1392 0.626 3064052 Maybridge4_003313 COc1cccc(OC)c1CN(C)C(=O)c2cnc(Oc3ccccc3)cc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G14 compound treatment 1.7264021E8 2.39E7 0.3 1.86377975E8 2.96E7 0.51 0.5707 0.9685 1245694 Maybridge4_003314 NNC(=O)Cn1c2ccccc2c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G15 compound treatment 1.58330069E8 9590000.0 0.12 1.70779702E8 1.4E7 0.24 0.255 0.9488 3064053 Maybridge4_003315 CC1CC(=O)NN=C1c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G16 compound treatment 1.5615674E8 7410000.0 0.09 1.7204246E8 1.53E7 0.26 0.251 0.903 3178582 Maybridge4_003316 COc1cc(/C=N\n2cn[nH]c2=S)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G17 compound treatment 1.40759957E8 -7980000.0 -0.1 1.61309417E8 4570000.0 0.08 -0.0155 -0.1222 1565631 Maybridge4_003317 CSc1nc2cccc(F)c2c(=O)n1c3ccc(C)c(C)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G18 compound treatment 1.49350417E8 608000.0 0.01 1.59668139E8 2930000.0 0.05 0.0408 0.8055 1496711 Maybridge4_003318 Cc1ccccc1NC(=O)COc2ccc3C(=O)CC(C)(C)Oc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G19 compound treatment 1.31670136E8 -1.71E7 -0.21 1.39837391E8 -1.69E7 -0.29 -0.3561 -0.989 3178583 Maybridge4_003319 CCc1nc(S)[nH]c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G20 compound treatment 1.64964552E8 1.62E7 0.2 1.58753369E8 2010000.0 0.03 0.1682 0.8151 1520911 Maybridge4_003320 O=C1CC(Sc2ccccc2N1)c3coc4ccccc4c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G21 compound treatment 1.54381261E8 5640000.0 0.07 1.57770642E8 1030000.0 0.02 0.0625 0.8569 1387364 Maybridge4_003321 CC(=O)N1CCc2cc(NC(=S)Nc3ccccc3Cl)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G22 compound treatment 1.60478174E8 1.17E7 0.15 1.56106337E8 -636000.0 -0.01 0.0964 0.653 1175310 Maybridge4_003322 O=C(COc1ccc(cc1)C2=Nc3ccccc3NC(C2)c4ccccc4)Nc5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G23 mock treatment 1.65663301E8 1.69E7 0.21 1.53221696E8 -3520000.0 -0.06 0.1075 0.4871 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 G24 mock treatment 1.57435224E8 8690000.0 0.11 1.5866638E8 1920000.0 0.03 0.1004 0.8813 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H01 compound treatment 1.61370509E8 1.26E7 0.16 1.8809743E8 3.14E7 0.54 0.4915 0.8783 3064847 Maybridge4_003323 N=C(NC(=S)Nc1ccccc1)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H02 compound treatment 1.65446746E8 1.67E7 0.21 1.80414829E8 2.37E7 0.41 0.4347 0.9529 1265943 Maybridge4_003324 Oc1cc(c2ccc(F)cc2)n(c3ccccc3)c(=O)c1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H03 compound treatment 1.63736548E8 1.5E7 0.19 1.6663983E8 9900000.0 0.17 0.2528 0.9986 1493327 Maybridge4_003325 CC(C)c1c(Br)c(=O)oc2c3CCCN4CCCc(cc12)c43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H04 compound treatment 1.74058491E8 2.53E7 0.32 1.85200858E8 2.85E7 0.49 0.569 0.9785 1020946 Maybridge4_003326 NC(=O)NCCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H05 compound treatment 1.75639359E8 2.69E7 0.34 1.87136475E8 3.04E7 0.52 0.6065 0.978 3064848 Maybridge4_003327 C/C(=N/O)/CC(c1ccccc1)c2c(O)c3ccccc3oc2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H06 compound treatment 1.78083525E8 2.93E7 0.37 1.59420811E8 2680000.0 0.05 0.2927 0.7891 1378346 Maybridge4_003328 Cn1c(=O)n(C)c2ncn(CC(O)COc3ccccc3)c2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H07 compound treatment 1.70200507E8 2.15E7 0.27 1.32943759E8 -2.38E7 -0.41 -0.0977 -0.2001 3064849 Maybridge4_003329 CO[C@@H]1O[C@H](COC(=O)c2ccccc2)[C@H](OC(=O)c3ccccc3)[C@H]1OC(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H08 compound treatment 1.78399881E8 2.97E7 0.37 1.11642726E8 -4.51E7 -0.77 -0.2828 -0.33 1554777 Maybridge4_003330 CCn1c2C(=O)CCCc2c3cc(OCc4ccccc4)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H09 compound treatment 1.93851121E8 4.51E7 0.57 1.12041354E8 -4.47E7 -0.77 -0.1409 -0.1481 3064850 Maybridge4_003331 OC1=C(C(=O)c2ccccc12)c3ccc(I)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H10 compound treatment 1.82233505E8 3.35E7 0.42 1.31499146E8 -2.52E7 -0.43 -0.0085 -0.0141 3178584 Maybridge4_003332 FC(F)(F)c1cccc(c1)n2c(S)nnc2Cn3nnc(n3)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H11 compound treatment 1.80030523E8 3.13E7 0.39 1.78003402E8 2.13E7 0.36 0.5349 0.9993 1668484 Maybridge4_003333 Fc1ccc(cc1)N(C(=O)C2(CC3CC4CC(C3)C2)C4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H12 compound treatment 1.688941E8 2.02E7 0.25 1.76000156E8 1.93E7 0.33 0.4119 0.9914 3064851 Maybridge4_003334 COc1ccc(CCN/2C(=O)CS\C2=N/C3CC3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H13 compound treatment 1.63717655E8 1.5E7 0.19 1.64406134E8 7660000.0 0.13 0.2256 0.9846 1561039 Maybridge4_003335 O=c1[nH]c2ccccc2c(=O)n1CCSc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H14 compound treatment 1.69915956E8 2.12E7 0.27 1.66345588E8 9600000.0 0.16 0.3041 0.9734 3064852 Maybridge4_003336 CC/N=C(/Nc1ccc(cc1)C(C)(C)C)\SCC2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H15 compound treatment 1.73592494E8 2.49E7 0.31 2.01510338E8 4.48E7 0.77 0.7623 0.9214 1155855 Maybridge4_003337 Oc1c(O)c(CN2CCCCC2)c3ccccc3c1CN4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H16 compound treatment 1.62746633E8 1.4E7 0.18 1.75979817E8 1.92E7 0.33 0.3571 0.9567 3064853 Maybridge4_003338 COC(=O)c1cccc(NC(=N)NC(=N)N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H17 compound treatment 1.48361348E8 -381000.0 0.0 1.56236469E8 -506000.0 -0.01 -0.0095 -0.9608 3178585 Maybridge4_003339 Clc1ccc(cc1)S(=O)(=O)C2=CC34CCCC4(C2)C=C(C3)S(=O)(=O)c5ccc(Cl)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H18 compound treatment 1.31449465E8 -1.73E7 -0.22 1.76925234E8 2.02E7 0.35 0.0909 0.2228 3064854 Maybridge4_003340 CC(=C)CC1C(=NNC1=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H19 compound treatment 1.05268413E8 -4.35E7 -0.55 1.67722536E8 1.1E7 0.19 -0.2527 -0.4381 3178586 Maybridge4_003341 CC1(C)O[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O1)n3cnc4c(N)ncnc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H20 compound treatment 8.5989776E7 -6.28E7 -0.79 1.68148554E8 1.14E7 0.2 -0.4186 -0.5161 3064855 Maybridge4_003342 Clc1ccc(NC(=S)NCC2CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H21 compound treatment 5.8365689E7 -9.04E7 -1.13 1.76789507E8 2.0E7 0.34 -0.559 -0.4719 1331091 Maybridge4_003343 CN(C)CCNc1cc(nc2ccccc12)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H22 compound treatment 1.64886286E8 1.61E7 0.2 2.5238933E8 9.56E7 1.64 1.3009 0.7886 1734961 Maybridge4_003344 CCCc1c(Cc2c(F)cccc2Cl)c(=O)oc3cc(O)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H23 mock treatment 5.17462E7 -9.7E7 -1.22 1.61266078E8 4520000.0 0.08 -0.8056 -0.6608 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 H24 mock treatment 1.58738326E8 1.0E7 0.13 1.52059879E8 -4680000.0 -0.08 0.032 0.2149 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I01 compound treatment 7.5520257E7 -7.32E7 -0.92 1.99518859E8 4.28E7 0.73 -0.1317 -0.1121 3178587 Maybridge4_003345 CC(C)(C)C(=O)OCc1nc(cs1)c2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I02 compound treatment 1.17559898E8 -3.12E7 -0.39 2.14870211E8 5.81E7 1.0 0.427 0.3994 1626253 Maybridge4_003346 CSc1c(C#N)c(N)nc2sc(C(=O)c3ccc(Cl)c(Cl)c3)c(N)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I03 compound treatment 1.00002162E8 -4.87E7 -0.61 2.19218937E8 6.25E7 1.07 0.3239 0.2629 1244996 Maybridge4_003347 CCNC(=O)N(Cc1ccccc1)Cc2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I04 compound treatment 1.47788142E8 -954000.0 -0.01 2.12928984E8 5.62E7 0.96 0.6716 0.6983 1073759 Maybridge4_003348 CSc1ncc(Br)c(n1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I05 compound treatment 2.12418197E8 6.37E7 0.8 2.14150647E8 5.74E7 0.98 1.2597 0.9947 3178588 Maybridge4_003349 CC(C)(C)NC(=O)Nc1cnccc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I06 compound treatment 2.13397086E8 6.47E7 0.81 2.16014472E8 5.93E7 1.01 1.291 0.9938 3064856 Maybridge4_003350 CCOC(=O)CC1=Nn2c(nnc2SC1)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I07 compound treatment 2.17592906E8 6.89E7 0.86 2.34813555E8 7.81E7 1.34 1.5557 0.9777 3178589 Maybridge4_003351 Cc1nc(C(=O)NCC(=O)c2ccc(Cl)cc2)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I08 compound treatment 2.47488897E8 9.87E7 1.24 2.48297736E8 9.16E7 1.57 1.9841 0.9932 1403866 Maybridge4_003352 O=c1cc([nH]c(=O)[nH]1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I09 compound treatment 2.15845701E8 6.71E7 0.84 2.18430323E8 6.17E7 1.06 1.3419 0.9937 3178590 Maybridge4_003353 COc1ccc(CN(C)C(=O)c2cnc(OC)cc2C(F)(F)F)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I10 compound treatment 1.99165677E8 5.04E7 0.63 1.99314866E8 4.26E7 0.73 0.9626 0.9975 1529338 Maybridge4_003354 CCCCc1ccc(NC(=O)CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I11 compound treatment 1.82486612E8 3.37E7 0.42 2.18987152E8 6.22E7 1.07 1.0527 0.9182 3064857 Maybridge4_003355 CN(C(=O)c1cn(C)c(=O)cc1C(F)(F)F)c2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I12 compound treatment 1.78402198E8 2.97E7 0.37 2.64685161E8 1.08E8 1.85 1.5697 0.8328 1141964 Maybridge4_003356 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3cccc4nonc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I13 compound treatment 1.69493217E8 2.08E7 0.26 2.2897198E8 7.22E7 1.24 1.0583 0.8376 3064858 Maybridge4_003357 CSc1nc(Nc2cccc(c2)C(F)(F)F)cc(c1C#N)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I14 compound treatment 1.66348229E8 1.76E7 0.22 2.22860772E8 6.61E7 1.13 0.9565 0.8294 1260487 Maybridge4_003358 Cc1ccc(Sc2ncccc2NC(=O)c3cccc4ccccc34)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I15 compound treatment 1.71342915E8 2.26E7 0.28 2.40046122E8 8.33E7 1.43 1.2088 0.8314 1269491 Maybridge4_003359 CCOC(=O)c1cnn2c1nc(Sc3cccc(OC)c3)c4ccccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I16 compound treatment 1.76035103E8 2.73E7 0.34 2.48014044E8 9.13E7 1.56 1.3469 0.8421 1008109 Maybridge4_003360 S=C(Nc1ccccn1)Nc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I17 compound treatment 1.59014248E8 1.03E7 0.13 2.2623706E8 6.95E7 1.19 0.9323 0.7791 3064859 Maybridge4_003361 O/N=C/Nc1ccc2nnc(c3ccccc3)n2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I18 compound treatment 1.79424514E8 3.07E7 0.38 2.47700709E8 9.1E7 1.56 1.3731 0.8561 1290576 Maybridge4_003362 Oc1ccc2c(=O)c(coc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I19 compound treatment 1.82444143E8 3.37E7 0.42 2.50767063E8 9.4E7 1.61 1.437 0.8635 3064860 Maybridge4_003363 Cc1ccc(Cc2cc(C)n[nH]c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I20 compound treatment 1.73605731E8 2.49E7 0.31 2.18723161E8 6.2E7 1.06 0.9708 0.8778 1499068 Maybridge4_003364 CC(=O)NC1C(c2ccccc2)S(=O)(=O)c3ccccc3NC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I21 compound treatment 1.78770429E8 3.0E7 0.38 2.36544149E8 7.98E7 1.37 1.2323 0.8696 1721722 Maybridge4_003365 CC(=O)N1CCc2cc(NC(=S)NCc3cccs3)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I22 compound treatment 1.58876825E8 1.01E7 0.13 2.23213962E8 6.65E7 1.14 0.8945 0.7812 1210152 Maybridge4_003366 CCC(=O)N1C(CC(=Nc2ccccc12)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I23 mock treatment 1.74605139E8 2.59E7 0.32 2.1545571E8 5.87E7 1.01 0.9401 0.8901 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 I24 mock treatment 1.67337481E8 1.86E7 0.23 2.26784304E8 7.0E7 1.2 1.0127 0.8291 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J01 compound treatment 1.97496833E8 4.88E7 0.61 1.91985868E8 3.52E7 0.6 0.8591 1.0 1243119 Maybridge4_003367 Cc1c(O)c(c2ccccc2)c(=O)n(c3ccccn3)c1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J02 compound treatment 2.06132635E8 5.74E7 0.72 2.35014604E8 7.83E7 1.34 1.4565 0.9576 1140611 Maybridge4_003368 CCCCc1c(O)cc(c2ccccc2)n(Cc3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J03 compound treatment 2.04420334E8 5.57E7 0.7 1.74882322E8 1.81E7 0.31 0.7135 0.9334 3178591 Maybridge4_003369 Cc1ccc(cc1)C(=O)/C=C\2/NCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J04 compound treatment 2.14062315E8 6.53E7 0.82 2.39291028E8 8.25E7 1.41 1.5786 0.9664 3178682 Maybridge4_003370 CC(=O)O[C@H]1[C@H](O[C@@H]2OC(C)(C)O[C@H]12)C(O)CO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J05 compound treatment 2.2244941E8 7.37E7 0.92 2.40012738E8 8.33E7 1.43 1.6617 0.978 1447328 Maybridge4_003371 CC(C)(C)C(=O)CC(Nc1ccccc1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J06 compound treatment 2.08356698E8 5.96E7 0.75 1.96042294E8 3.93E7 0.67 1.0045 0.9986 1256088 Maybridge4_003372 C=CCC1(CCCCC1)NCCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J07 compound treatment 2.1367816E8 6.49E7 0.81 2.30948799E8 7.42E7 1.27 1.4742 0.9769 1171716 Maybridge4_003373 CN1CCCC(C1)OC(=O)C2=C(C)NC3(O)c4ccccc4C(=O)C23O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J08 compound treatment 2.00256127E8 5.15E7 0.65 2.44440161E8 8.77E7 1.5 1.5185 0.9291 1583880 Maybridge4_003374 CC(C)(C)Oc1ccc(CC(CO)NC(=O)OCC2c3ccccc3-c4ccccc24)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J09 compound treatment 2.16605889E8 6.79E7 0.85 1.67571415E8 1.08E7 0.19 0.733 0.8414 1604468 Maybridge4_003375 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccccc3Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J10 compound treatment 1.18970862E8 -2.98E7 -0.37 1.64298192E8 7560000.0 0.13 -0.1726 -0.4368 3064861 Maybridge4_003376 Cc1cc(OC(=O)c2ccco2)nc(SCc3c(Cl)cccc3Cl)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J11 compound treatment 2.04062848E8 5.53E7 0.69 1.75104765E8 1.84E7 0.31 0.713 0.9359 3178683 Maybridge4_003377 CC(C)C1(C)N2C(=O)c3ccccc3C2=NC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J12 compound treatment 2.09655347E8 6.09E7 0.76 2.46653697E8 8.99E7 1.54 1.6286 0.9478 3064862 Maybridge4_003378 O=C1CS/C(=N\C2CC2)/N1Cc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J13 compound treatment 1.99798067E8 5.11E7 0.64 2.18401584E8 6.17E7 1.06 1.1992 0.9713 1167872 Maybridge4_003379 OC(=O)CNC(=O)CSc1ccccn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J14 compound treatment 2.08051759E8 5.93E7 0.74 1.97765961E8 4.1E7 0.7 1.0227 0.9996 1457281 Maybridge4_003380 COCc1cc(OC(=O)N(C)C)nc(n1)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J15 compound treatment 2.0125191E8 5.25E7 0.66 2.62771548E8 1.06E8 1.82 1.7492 0.9059 3178684 Maybridge4_003381 CN(C)/C=N/n1cnc2sc3CCCCc3c2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J16 compound treatment 1.92283991E8 4.35E7 0.55 1.75632636E8 1.89E7 0.32 0.6149 0.9687 3178685 Maybridge4_003382 NC(=N)NC(=N)Nc1cc(n[nH]1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J17 compound treatment 1.96152814E8 4.74E7 0.59 2.50166891E8 9.34E7 1.6 1.5514 0.9092 1294257 Maybridge4_003383 COc1cc(Cc2cc(OC)c(C)cc2OC)c(OC)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J18 compound treatment 2.05877044E8 5.71E7 0.72 2.50693439E8 9.4E7 1.61 1.644 0.9337 3178686 Maybridge4_003384 CCCCc1c(C)nc(nc1O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J19 compound treatment 1.83260983E8 3.45E7 0.43 2.42075657E8 8.53E7 1.46 1.3391 0.8789 3176922 Maybridge4_003385 OC[C@H]1O[C@H](C[C@@H]1O)n2cc(Br)c(=O)[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J20 compound treatment 1.78160231E8 2.94E7 0.37 1.96786049E8 4.0E7 0.69 0.7456 0.9578 3064863 Maybridge4_003386 COc1cc(/C=N/c2ccc(Cl)cc2)ccc1OC(=O)/C=C/c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J21 compound treatment 1.72934401E8 2.42E7 0.3 2.3535597E8 7.86E7 1.35 1.1661 0.8453 1169652 Maybridge4_003387 C1CN(CCO1)c2c3CCc4ccccc4-c3nc5ccccc25 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J22 compound treatment 1.6097828E8 1.22E7 0.15 2.08362142E8 5.16E7 0.88 0.7334 0.8177 1608425 Maybridge4_003388 CCCC1=NN(C(=O)C(C)(C)C)C(=O)C1Cc2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J23 mock treatment 1.85491493E8 3.67E7 0.46 2.41090528E8 8.43E7 1.44 1.3469 0.8887 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 J24 mock treatment 1.74126344E8 2.54E7 0.32 2.16382679E8 5.96E7 1.02 0.9471 0.8856 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K01 compound treatment 3.781399E7 -1.11E8 -1.39 1.41002988E8 -1.57E7 -0.27 -1.1745 -0.8286 3064864 Maybridge4_003389 CSC1=N/C(=C\c2ccccc2O)/C(=O)N1Cc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K02 compound treatment 5.8855981E7 -8.99E7 -1.13 1.66989013E8 1.02E7 0.18 -0.6733 -0.59 1422721 Maybridge4_003390 CCOC(=O)c1cnn(C(=O)COc2ccc(C)c3CCCc32)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K03 compound treatment 6.1161692E7 -8.76E7 -1.1 1.67953351E8 1.12E7 0.19 -0.6412 -0.5749 3178687 Maybridge4_003391 CSC1=N/C(=C\c2ccc(Cl)cc2)/C(=O)N1CCc3c[nH]c4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K04 compound treatment 9.2437813E7 -5.63E7 -0.71 1.53041301E8 -3700000.0 -0.06 -0.5442 -0.7675 1502240 Maybridge4_003392 COC(=O)c1[nH]c(C(=O)OC)c(O)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K05 compound treatment 1.35222245E8 -1.35E7 -0.17 1.63900807E8 7160000.0 0.12 -0.0333 -0.1591 3064865 Maybridge4_003393 COc1cccc(NC(=O)c2cnccc2C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K06 compound treatment 1.28058837E8 -2.07E7 -0.26 1.6441026E8 7670000.0 0.13 -0.0907 -0.3118 3178688 Maybridge4_003394 CCOC(=O)/C=C(\C)/Nc1cccc(N\C(=C\C(=O)OCC)\C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K07 compound treatment 1.55858768E8 7120000.0 0.09 1.78830951E8 2.21E7 0.38 0.3305 0.8507 3064866 Maybridge4_003395 FC(F)(F)c1ccc(cc1)c2nc(NC(=O)Nc3ccccc3)cs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K08 compound treatment 1.42619696E8 -6120000.0 -0.08 1.62395695E8 5650000.0 0.1 0.0141 0.1143 1570272 Maybridge4_003396 CCC1N(CCc2c1[nH]c3ccccc23)C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K09 compound treatment 1.50737386E8 1990000.0 0.03 1.68425464E8 1.17E7 0.2 0.1591 0.7894 3064867 Maybridge4_003397 FC(F)(F)c1ccncc1C(=O)NC(=O)Nc2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K10 compound treatment 1.57698244E8 8960000.0 0.11 1.56913658E8 171000.0 0.0 0.0815 0.7253 1687043 Maybridge4_003398 Cc1cc(C)c(COc2ccc3C(=O)CC(C)(C)Oc3c2C)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K11 compound treatment 1.63028077E8 1.43E7 0.18 1.58685129E8 1940000.0 0.03 0.1502 0.8243 3064868 Maybridge4_003399 FC(F)(F)c1ccc(nc1)n2nc(oc2=O)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K12 compound treatment 1.53017721E8 4280000.0 0.05 1.47155436E8 -9590000.0 -0.16 -0.0781 -0.4525 1713701 Maybridge4_003400 COc1cccc(c1)C2CCN(CC2)C(=O)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K13 compound treatment 1.6173196E8 1.3E7 0.16 1.51342248E8 -5400000.0 -0.09 0.0499 0.2661 3064869 Maybridge4_003401 Cc1cc(C)c2c(=O)cc(oc2c1)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K14 compound treatment 1.67125565E8 1.84E7 0.23 1.51241186E8 -5500000.0 -0.09 0.0965 0.3873 3178689 Maybridge4_003402 FC(F)(F)c1ccc(cc1)C(=O)Nc2cccnc2Sc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K15 compound treatment 1.58819302E8 1.01E7 0.13 1.54392405E8 -2350000.0 -0.04 0.0609 0.4594 1294252 Maybridge4_003403 CCOC(=O)c1cnn2c1nc(Sc3ccc(C)cc3)c4ccccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K16 compound treatment 1.50258704E8 1520000.0 0.02 1.40489211E8 -1.63E7 -0.28 -0.1833 -0.6572 1553374 Maybridge4_003404 C1CN(CCO1)c2nnc(c3ccccc3)c(n2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K17 compound treatment 1.62816755E8 1.41E7 0.18 1.59594853E8 2850000.0 0.05 0.1594 0.87 1663105 Maybridge4_003405 COc1ccc(Cc2cc(n[nH]c2=O)c3cccs3)c(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K18 compound treatment 1.55122142E8 6380000.0 0.08 1.52350339E8 -4390000.0 -0.08 0.0034 0.0312 3064947 Maybridge4_003406 OC[C@H]1OC(Oc2ccc(cc2)c3coc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K19 compound treatment 1.54578389E8 5840000.0 0.07 1.68022607E8 1.13E7 0.19 0.1883 0.9119 1252838 Maybridge4_003407 Cc1cc(C)n(NC(=S)NC2CCCC2)c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K20 compound treatment 1.623159E8 1.36E7 0.17 1.66193344E8 9450000.0 0.16 0.2348 0.9997 1353357 Maybridge4_003408 S=C1CC(Sc2ccccc2N1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K21 compound treatment 1.42536729E8 -6210000.0 -0.08 1.38008077E8 -1.87E7 -0.32 -0.2818 -0.854 1332355 Maybridge4_003409 CC(=O)N1CCc2cc(NC(=S)NC3CCCCCC3)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K22 compound treatment 1.54851207E8 6110000.0 0.08 1.60691302E8 3950000.0 0.07 0.102 0.998 3064948 Maybridge4_003410 CNC(=O)c1cc(OC)ccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K23 mock treatment 1.64274884E8 1.55E7 0.19 1.55185182E8 -1560000.0 -0.03 0.1189 0.6047 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 K24 mock treatment 1.57699869E8 8960000.0 0.11 1.64200101E8 7460000.0 0.13 0.1697 0.998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L01 compound treatment 2.63814371E8 1.15E8 1.44 2.85074364E8 1.28E8 2.2 2.5741 0.9793 3064949 Maybridge4_003411 Cc1ncc(CO)c(/C=N/O)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L02 compound treatment 1.80596465E8 3.19E7 0.4 1.99733638E8 4.3E7 0.74 0.8029 0.9588 2085598 Maybridge4_003412 CSc1sc(=S)sc1SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L03 compound treatment 1.72908162E8 2.42E7 0.3 1.71684251E8 1.49E7 0.26 0.3952 0.9964 1341478 Maybridge4_003413 NNC(=O)CC1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L04 compound treatment 1.69722756E8 2.1E7 0.26 1.25129623E8 -3.16E7 -0.54 -0.1965 -0.3266 1914392 Maybridge4_003414 O=C(c1ccccc1)n2ccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L05 compound treatment 1.90592812E8 4.19E7 0.52 1.81676624E8 2.49E7 0.43 0.673 0.9947 3178690 Maybridge4_003415 C(SC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L06 compound treatment 1.59529538E8 1.08E7 0.14 1.1025769E8 -4.65E7 -0.8 -0.467 -0.5786 1103414 Maybridge4_003416 OC(=O)C1CCCN1C(=O)OCC2c3ccccc3-c4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L07 compound treatment 1.38350455E8 -1.04E7 -0.13 1.08515768E8 -4.82E7 -0.83 -0.6759 -0.8087 3064950 Maybridge4_003417 Oc1ccccc1c2cc(c(C#N)c(=O)[nH]2)c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L08 compound treatment 1.75051888E8 2.63E7 0.33 1.22198936E8 -3.45E7 -0.59 -0.1847 -0.2728 3178691 Maybridge4_003418 FC(F)(F)c1cccc(c1)N2CCN(CC2)C3=Cc4ccccc4C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L09 compound treatment 1.56470611E8 7730000.0 0.1 1.2715577E8 -2.96E7 -0.51 -0.2896 -0.5616 3064952 Maybridge4_003419 O=C(/C=C\1/NCCOC1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L10 compound treatment 1.76331329E8 2.76E7 0.35 1.17135656E8 -3.96E7 -0.68 -0.2347 -0.3083 1604086 Maybridge4_003420 Clc1cccc(Cl)c1Cn2nnc(n2)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L11 compound treatment 1.77412356E8 2.87E7 0.36 1.12217109E8 -4.45E7 -0.76 -0.2846 -0.3377 1004954 Maybridge4_003421 N(C(=Nc1ccccc1)Nc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L12 compound treatment 1.74739687E8 2.6E7 0.33 1.16099691E8 -4.06E7 -0.7 -0.2613 -0.3401 3178692 Maybridge4_003422 CC1CN(CC(C)O1)c2ccc(NC(=S)NCc3ccco3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L13 compound treatment 1.80382905E8 3.16E7 0.4 1.25116383E8 -3.16E7 -0.54 -0.1021 -0.1522 3178693 Maybridge4_003423 FC(F)(F)C(NC(=O)Oc1ccccc1)(Oc2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L14 compound treatment 1.96615699E8 4.79E7 0.6 2.01018344E8 4.43E7 0.76 0.9606 0.9934 3064954 Maybridge4_003424 COCc1cc(O)nc(SCC(=O)C(C)(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L15 compound treatment 1.81385865E8 3.26E7 0.41 1.99859802E8 4.31E7 0.74 0.8115 0.9614 1022292 Maybridge4_003425 O=C1NC(Cc2ccccc2)C(=O)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L16 compound treatment 1.87668158E8 3.89E7 0.49 1.21789251E8 -3.5E7 -0.6 -0.0778 -0.1007 3064955 Maybridge4_003426 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nnn(CC(=O)c3ccc(Cl)cc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L17 compound treatment 1.51072121E8 2330000.0 0.03 8.7628785E7 -6.91E7 -1.18 -0.8159 -0.6894 1517030 Maybridge4_003427 CC(=O)Oc1ccc(OC(=O)C)c2cc3c(OC(=O)C)ccc(OC(=O)C)c3cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L18 compound treatment 1.84880139E8 3.61E7 0.45 1.64991342E8 8250000.0 0.14 0.4204 0.8854 3064957 Maybridge4_003428 CCN(CC)C(=S)Oc1nc(nc(C)c1CC(=C)C)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L19 compound treatment 1.84137094E8 3.54E7 0.44 1.77440969E8 2.07E7 0.35 0.5645 0.9937 1414175 Maybridge4_003429 NNC(=O)C1C(C1c2ccccc2)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L20 compound treatment 1.83345295E8 3.46E7 0.43 1.66300271E8 9560000.0 0.16 0.4226 0.9111 1151671 Maybridge4_003430 CC(C)(C)C(=O)CSc1nc2ccccc2c(=O)n1CC3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L21 compound treatment 1.79805549E8 3.11E7 0.39 1.69736091E8 1.3E7 0.22 0.4328 0.9646 1294591 Maybridge4_003431 C1CCN(CC1)c2cc(nc3ccccc23)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L22 compound treatment 1.60664752E8 1.19E7 0.15 1.65596946E8 8850000.0 0.15 0.2129 1.0 3178694 Maybridge4_003432 CCCC1=NN(C(=O)/C=C/c2cccs2)C(=O)C1Cc3c(F)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L23 mock treatment 1.66616204E8 1.79E7 0.22 1.57689176E8 947000.0 0.02 0.17 0.7562 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 L24 mock treatment 1.58752323E8 1.0E7 0.13 1.65451283E8 8710000.0 0.15 0.1942 0.9964 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M01 compound treatment 3.6795395E7 -1.12E8 -1.4 1.00979639E8 -5.58E7 -0.95 -1.668 -0.9823 1614322 Maybridge4_003433 CC(C)NC(=O)N(Cc1ccccc1)Cc2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M02 compound treatment 4.5713567E7 -1.03E8 -1.29 1.01161868E8 -5.56E7 -0.95 -1.5867 -0.9886 1632856 Maybridge4_003434 CCCCn1c(O)cc(C)c(C#N)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M03 compound treatment 6.5192838E7 -8.35E7 -1.05 1.08266468E8 -4.85E7 -0.83 -1.3279 -0.9933 3178695 Maybridge4_003435 CSC1=N/C(=C\Nc2cccc(Cl)c2)/C(=O)N1Cc3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M04 compound treatment 1.32453338E8 -1.63E7 -0.2 1.23590958E8 -3.32E7 -0.57 -0.5458 -0.9048 1626500 Maybridge4_003436 S=C(NCC1CC1)Nc2ccc3[nH]ccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M05 compound treatment 1.40394755E8 -8350000.0 -0.1 1.24059622E8 -3.27E7 -0.56 -0.4696 -0.8251 3178774 Maybridge4_003437 FC(F)(F)c1ccncc1C(=O)Nc2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M06 compound treatment 1.58841743E8 1.01E7 0.13 1.38735812E8 -1.8E7 -0.31 -0.1284 -0.3852 3064958 Maybridge4_003438 NNC(=O)CC1=Nn2c(nnc2SC1)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M07 compound treatment 1.50277643E8 1540000.0 0.02 1.21815565E8 -3.49E7 -0.6 -0.4091 -0.684 3178775 Maybridge4_003439 CCN(Cc1cc(Cl)cc(Cl)c1)C(=O)c2cnc(OC)cc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M08 compound treatment 1.45525768E8 -3220000.0 -0.04 1.27963811E8 -2.88E7 -0.49 -0.3769 -0.7625 1042478 Maybridge4_003440 CNc1cc(=O)n(C)c(=O)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M09 compound treatment 1.33996111E8 -1.47E7 -0.18 1.24957031E8 -3.18E7 -0.54 -0.5155 -0.8971 3064959 Maybridge4_003441 Fc1ccc(NC(=O)c2cnccc2C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M10 compound treatment 1.2693408E8 -2.18E7 -0.27 1.12723532E8 -4.4E7 -0.75 -0.7263 -0.906 1313888 Maybridge4_003442 COc1cc(ccc1O)C2=NC(O)C(=O)Nc3ccc(Cl)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M11 compound treatment 1.42596832E8 -6150000.0 -0.08 1.26346504E8 -3.04E7 -0.52 -0.4224 -0.8031 3064960 Maybridge4_003443 NNC(=O)c1cc(OCC(F)(F)F)nc(OCC(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M12 compound treatment 1.45101311E8 -3640000.0 -0.05 1.27783167E8 -2.9E7 -0.5 -0.3828 -0.769 3178776 Maybridge4_003444 Fc1ccc(cc1)c2nnc(CSCc3cccc4ccccc34)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M13 compound treatment 1.43572325E8 -5170000.0 -0.06 1.36111755E8 -2.06E7 -0.35 -0.2956 -0.8232 3178777 Maybridge4_003445 Clc1ccc(cc1)C(=O)CC(C(=O)c2ccccc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M14 compound treatment 1.30335287E8 -1.84E7 -0.23 1.18175653E8 -3.86E7 -0.66 -0.6301 -0.9009 3064961 Maybridge4_003446 Nn1c(cc(c(C#N)c1=O)C(F)(F)F)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M15 compound treatment 1.36002205E8 -1.27E7 -0.16 1.34867111E8 -2.19E7 -0.37 -0.3778 -0.9279 3178778 Maybridge4_003447 CCOC(=O)c1cnn2c1nc(Oc3cc(cc(c3)C(F)(F)F)C(F)(F)F)c4ccccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M16 compound treatment 1.33656352E8 -1.51E7 -0.19 1.39719717E8 -1.7E7 -0.29 -0.3399 -0.9782 1593342 Maybridge4_003448 CC(C)NC(=O)c1cccc2cccc(Sc3ccccc3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M17 compound treatment 1.34748561E8 -1.4E7 -0.18 1.314047E8 -2.53E7 -0.43 -0.4308 -0.9207 1609655 Maybridge4_003449 O=c1[nH]nc(cc1CC2CCCCC2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M18 compound treatment 1.41162084E8 -7580000.0 -0.1 1.34966903E8 -2.18E7 -0.37 -0.3308 -0.86 1690877 Maybridge4_003450 O=c1n(c2ccccc2)c(=O)n3C4CCC(C4)n31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M19 compound treatment 1.20174229E8 -2.86E7 -0.36 1.31189825E8 -2.56E7 -0.44 -0.5627 -0.9951 1634815 Maybridge4_003451 Cc1cc(C)n(NC(=S)NCc2cccs2)c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M20 compound treatment 1.20662185E8 -2.81E7 -0.35 1.31457021E8 -2.53E7 -0.43 -0.5551 -0.9948 3065001 Maybridge4_003452 C1Sc2ccccc2C3=Nc4ccccc4SC(C13)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M21 compound treatment 1.2234024E8 -2.64E7 -0.33 1.25072815E8 -3.17E7 -0.54 -0.6175 -0.9721 3065002 Maybridge4_003453 CN(C)/C=C/C(=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(C)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M22 compound treatment 1.28039095E8 -2.07E7 -0.26 1.36841715E8 -1.99E7 -0.34 -0.4245 -0.991 3065003 Maybridge4_003454 NC(=O)c1cc(Cl)ccc1I 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M23 mock treatment 1.21287015E8 -2.75E7 -0.34 1.3190014E8 -2.48E7 -0.43 -0.5442 -0.9945 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 M24 mock treatment 1.19695385E8 -2.9E7 -0.36 1.35335964E8 -2.14E7 -0.37 -0.5168 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N01 compound treatment 1.1154768E8 -3.72E7 -0.47 1.18546712E8 -3.82E7 -0.65 -0.7923 -0.9863 1588083 Maybridge4_003455 CC(=O)Oc1ccc(cc1)c2coc3cc(OC(=O)C)cc(OC(=O)C)c3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N02 compound treatment 1.33143622E8 -1.56E7 -0.2 1.25791206E8 -3.1E7 -0.53 -0.513 -0.9083 1124592 Maybridge4_003456 CC1CC2(CCCCC2)N(Cc3ccccc13)S(=O)(=O)c4ccc(C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N03 compound treatment 1.4068466E8 -8060000.0 -0.1 1.44537443E8 -1.22E7 -0.21 -0.2192 -0.9445 3065004 Maybridge4_003457 CNC(=S)C1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N04 compound treatment 1.58930693E8 1.02E7 0.13 1.38406719E8 -1.83E7 -0.31 -0.1316 -0.3882 1007974 Maybridge4_003458 O=C(Nc1ccccc1)OC2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N05 compound treatment 1.5044751E8 1710000.0 0.02 1.22568295E8 -3.42E7 -0.58 -0.3985 -0.6808 3178779 Maybridge4_003459 CC(CNc1ccccc1)/C(=N/c2ccccc2)/Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N06 compound treatment 1.55207304E8 6460000.0 0.08 1.26004985E8 -3.07E7 -0.53 -0.3147 -0.5911 1711036 Maybridge4_003460 CC1(C)c2ccccc2N3CC(=O)N(CC=C)C31C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N07 compound treatment 1.51293065E8 2550000.0 0.03 1.23240757E8 -3.35E7 -0.57 -0.3829 -0.6666 854262 Maybridge4_003461 CC(N)(Cc1cccc(O)c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N08 compound treatment 1.48724872E8 -17500.0 0.0 1.15751684E8 -4.1E7 -0.7 -0.4963 -0.7073 1129507 Maybridge4_003462 CC(N(C(=O)c1sc2ccccc2c1Cl)c3ccccn3)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N09 compound treatment 1.54080169E8 5340000.0 0.07 7.2005837E7 -8.47E7 -1.45 -0.9783 -0.6737 1387784 Maybridge4_003463 COc1ccc(Sc2ccccc2COC(=O)C)c(c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N10 compound treatment 1.51809703E8 3070000.0 0.04 1.08297095E8 -4.84E7 -0.83 -0.5592 -0.6736 1366361 Maybridge4_003464 NNC(=O)Cn1nnc(n1)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N11 compound treatment 1.43953799E8 -4790000.0 -0.06 1.2356368E8 -3.32E7 -0.57 -0.4441 -0.7776 3178780 Maybridge4_003465 CC1(C)NCS[C@H]1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N12 compound treatment 1.37758598E8 -1.1E7 -0.14 1.08027017E8 -4.87E7 -0.83 -0.6871 -0.8129 2078075 Maybridge4_003466 CC[n+]1c(C)csc1Nc2ccc(cc2)N3CC(C)OC(C)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N13 compound treatment 1.38576789E8 -1.02E7 -0.13 1.2301482E8 -3.37E7 -0.58 -0.4984 -0.843 3178781 Maybridge4_003467 CCOC(NC(=O)Nc1ccc(Br)cc1)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N14 compound treatment 1.5287119E8 4130000.0 0.05 1.269325E8 -2.98E7 -0.51 -0.3242 -0.6321 3065007 Maybridge4_003468 FC(F)(F)c1cc(=O)oc2cc(NC(=O)c3cc(Cl)cc(Cl)c3)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N15 compound treatment 1.30866611E8 -1.79E7 -0.22 9.0536193E7 -6.62E7 -1.13 -0.9599 -0.8309 1675436 Maybridge4_003469 CCOC(=O)c1c(C)n(O)c2ccc3nonc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N16 compound treatment 1.48626797E8 -116000.0 0.0 6.6055487E7 -9.07E7 -1.55 -1.0987 -0.7078 1084802 Maybridge4_003470 CC(C)CCc1c(C)nc(N)nc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N17 compound treatment 1.32313612E8 -1.64E7 -0.21 1.19646622E8 -3.71E7 -0.64 -0.5947 -0.8909 1383041 Maybridge4_003471 Clc1ccc(C(=O)N2CCC(CC2)NC(=O)c3ccccc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N18 compound treatment 1.36585046E8 -1.22E7 -0.15 1.32551929E8 -2.42E7 -0.41 -0.4006 -0.9079 3065008 Maybridge4_003472 CS/C(=N/C(C)(C)C)/Nc1ccccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N19 compound treatment 1.44568755E8 -4170000.0 -0.05 1.30171474E8 -2.66E7 -0.45 -0.3586 -0.7833 1673966 Maybridge4_003473 Cc1c(NC(=O)C(C)(C)C)c(=O)n(c2ccccc2)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N20 compound treatment 1.23333439E8 -2.54E7 -0.32 1.1432222E8 -4.24E7 -0.73 -0.7388 -0.9317 1479223 Maybridge4_003474 Cc1cc(Nc2ccc(F)c(Cl)c2)nc(NC(=O)C(C)(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N21 compound treatment 1.28733432E8 -2.0E7 -0.25 1.24209058E8 -3.25E7 -0.56 -0.5713 -0.9352 1920716 Maybridge4_003475 CC(C)COc1ccc(cc1)/C(=N\O)/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N22 compound treatment 1.21825826E8 -2.69E7 -0.34 1.23496078E8 -3.32E7 -0.57 -0.6412 -0.9689 3178782 Maybridge4_003476 CC(=C)CC1C(=NN(C1=O)S(=O)(=O)c2ccccc2Cl)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N23 mock treatment 1.2927673E8 -1.95E7 -0.24 1.34143472E8 -2.26E7 -0.39 -0.4462 -0.9754 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 N24 mock treatment 1.18460965E8 -3.03E7 -0.38 1.36325012E8 -2.04E7 -0.35 -0.5157 -0.9991 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O01 compound treatment 4.1983355E7 -1.07E8 -1.34 1.24498578E8 -3.22E7 -0.55 -1.3373 -0.9232 3178783 Maybridge4_003477 CSC1=N/C(=C\c2ccc(Cl)cc2)/C(=O)N1CCOc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O02 compound treatment 8.3668338E7 -6.51E7 -0.82 1.30411618E8 -2.63E7 -0.45 -0.8959 -0.9608 3065009 Maybridge4_003478 Cc1ccc(OCc2nnc(S)n2C3CCCCC3)c4CCCc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O03 compound treatment 7.4453126E7 -7.43E7 -0.93 1.21713252E8 -3.5E7 -0.6 -1.083 -0.9773 1042314 Maybridge4_003479 CNC(=O)Nc1cccc2cccnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O04 compound treatment 1.31196249E8 -1.75E7 -0.22 1.14672395E8 -4.21E7 -0.72 -0.6649 -0.8829 1378461 Maybridge4_003480 S=C(NC1CCCCC1)Nc2ccc3[nH]ccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O05 compound treatment 1.46315791E8 -2430000.0 -0.03 1.31054179E8 -2.57E7 -0.44 -0.3325 -0.7543 3178784 Maybridge4_003481 FC(F)(F)c1ccncc1C(=O)NCc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O06 compound treatment 1.46668044E8 -2070000.0 -0.03 1.31157074E8 -2.56E7 -0.44 -0.3281 -0.7478 3065010 Maybridge4_003482 CC(C)(C)C(=S)Nc1cccc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O07 compound treatment 1.51077127E8 2330000.0 0.03 1.39372774E8 -1.74E7 -0.3 -0.1895 -0.6344 3178785 Maybridge4_003483 COc1cccc(CNC(=O)c2cnc(OC)cc2C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O08 compound treatment 1.44670037E8 -4070000.0 -0.05 1.23417088E8 -3.33E7 -0.57 -0.4395 -0.7674 1115300 Maybridge4_003484 NNC(=O)COc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O09 compound treatment 1.34859106E8 -1.39E7 -0.17 1.26190914E8 -3.06E7 -0.52 -0.493 -0.8943 3178786 Maybridge4_003485 NC(=O)C1=CN(CCC1C(F)(F)F)C(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O10 compound treatment 1.21246775E8 -2.75E7 -0.34 1.25373801E8 -3.14E7 -0.54 -0.6236 -0.9771 1008942 Maybridge4_003486 Cc1cccc(NC(=O)Nc2cccc(C)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O11 compound treatment 1.27025905E8 -2.17E7 -0.27 1.24302055E8 -3.24E7 -0.56 -0.5853 -0.9463 3178787 Maybridge4_003487 FC(F)(F)COc1ncccc1C(=O)NCc2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O12 compound treatment 1.09577914E8 -3.92E7 -0.49 1.09431313E8 -4.73E7 -0.81 -0.9201 -0.9713 1449652 Maybridge4_003488 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccc(CNC(=O)c4ccccc4)s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O13 compound treatment 1.28333151E8 -2.04E7 -0.26 1.24501778E8 -3.22E7 -0.55 -0.5713 -0.939 3178788 Maybridge4_003489 COC(=O)c1cc2cc(Br)ccc2c(Br)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O14 compound treatment 1.13368172E8 -3.54E7 -0.44 1.20246703E8 -3.65E7 -0.62 -0.7555 -0.986 1523809 Maybridge4_003490 CCOC(=O)COc1nc(C)c(CC=C)c(C)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O15 compound treatment 1.21327702E8 -2.74E7 -0.34 1.16790463E8 -4.0E7 -0.68 -0.7268 -0.9494 1444175 Maybridge4_003491 CCOC(=O)c1cnn2c1nc(N3CC(C)CC(C)C3)c4ccccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O16 compound treatment 1.12349588E8 -3.64E7 -0.46 1.22441515E8 -3.43E7 -0.59 -0.738 -0.9923 3065040 Maybridge4_003492 O=C1/C(=C/c2ccc3ccccc3c2)/COc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O17 compound treatment 1.26925052E8 -2.18E7 -0.27 1.40419578E8 -1.63E7 -0.28 -0.3911 -0.9999 3065041 Maybridge4_003493 Cc1cc(CO)cc(C)c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O18 compound treatment 1.30053708E8 -1.87E7 -0.23 1.23274779E8 -3.35E7 -0.57 -0.5709 -0.9222 1280927 Maybridge4_003494 O=c1n(c2ccccc2)c(=O)n3C4CC(C=C4)n31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O19 compound treatment 1.24475991E8 -2.43E7 -0.3 1.3179938E8 -2.49E7 -0.43 -0.5172 -0.9862 3065042 Maybridge4_003495 CC1=C(Sc2ccccc2N1)C(=O)Nn3cnc4cccc(F)c4c3=N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O20 compound treatment 1.18608014E8 -3.01E7 -0.38 1.31413345E8 -2.53E7 -0.43 -0.5739 -0.9977 3065043 Maybridge4_003496 Cc1ccc(cc1)C2CC(=Nc3ccccc3S2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O21 compound treatment 1.1760934E8 -3.11E7 -0.39 1.24915598E8 -3.18E7 -0.54 -0.6614 -0.9867 1222795 Maybridge4_003497 CCOC(=O)c1cnn(C(=O)COc2ccc(cc2C(C)(C)C)C(C)(C)C)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O22 compound treatment 1.21844041E8 -2.69E7 -0.34 1.23395007E8 -3.33E7 -0.57 -0.6422 -0.9685 3065044 Maybridge4_003498 Cc1cc(nc2CC(C)(C)C/C(=N/O)/c12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O23 mock treatment 1.21549845E8 -2.72E7 -0.34 1.25244667E8 -3.15E7 -0.54 -0.6225 -0.9756 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 O24 mock treatment 1.21315793E8 -2.74E7 -0.34 1.38346401E8 -1.84E7 -0.31 -0.466 -0.999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P01 compound treatment 1.1847645E8 -3.03E7 -0.38 1.21452114E8 -3.53E7 -0.6 -0.6956 -0.975 1411988 Maybridge4_003499 O=C(CC#N)NC(=O)NC1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P02 compound treatment 1.11604083E8 -3.71E7 -0.47 1.20889812E8 -3.59E7 -0.61 -0.7634 -0.9908 1452749 Maybridge4_003500 CC1CC2(CCCCC2)N(Cc3ccccc13)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P03 compound treatment 1.17433174E8 -3.13E7 -0.39 1.09894191E8 -4.68E7 -0.8 -0.8448 -0.946 2102798 Maybridge4_003501 COC(=O)/C=C\1/OC(=CC1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P04 compound treatment 1.19797022E8 -2.89E7 -0.36 1.26282136E8 -3.05E7 -0.52 -0.6255 -0.9844 1582498 Maybridge4_003502 CC(=O)NC(=O)NCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P05 compound treatment 1.20370769E8 -2.84E7 -0.36 1.28045829E8 -2.87E7 -0.49 -0.599 -0.9875 3065047 Maybridge4_003503 CCOC(=O)CC1=NC(=O)CS1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P06 compound treatment 1.18511311E8 -3.02E7 -0.38 1.16023133E8 -4.07E7 -0.7 -0.761 -0.9591 1631994 Maybridge4_003504 Cc1ccc2N3CC(=O)N(Cc4ccccc4)C3(C)C(C)(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P07 compound treatment 1.24197505E8 -2.45E7 -0.31 1.29863359E8 -2.69E7 -0.46 -0.5431 -0.9809 3065048 Maybridge4_003505 CC(=O)N1CC(O)C[C@H]1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P08 compound treatment 1.14266558E8 -3.45E7 -0.43 1.1273984E8 -4.4E7 -0.75 -0.8384 -0.9653 3178789 Maybridge4_003506 CN1N=C(C)C(Cc2c(Cl)cccc2Cl)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P09 compound treatment 1.18901727E8 -2.98E7 -0.37 1.13219654E8 -4.35E7 -0.75 -0.7915 -0.9493 1247915 Maybridge4_003507 O=C(Oc1ccc(Oc2ccccc2)cc1)N3CCC(CC3)OC(=O)n4ccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P10 compound treatment 3.0033151E7 -1.19E8 -1.49 2.3957499E7 -1.33E8 -2.27 -2.6602 -0.979 3065049 Maybridge4_003508 CN(C)/N=C(\Cn1nnc(n1)N2CCCC2)/c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P11 compound treatment 1.21049827E8 -2.77E7 -0.35 1.22228041E8 -3.45E7 -0.59 -0.6634 -0.968 1294581 Maybridge4_003509 OC(=O)c1ccc2cc[nH]c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P12 compound treatment 1.19517877E8 -2.92E7 -0.37 1.19170854E8 -3.76E7 -0.64 -0.714 -0.9645 1153919 Maybridge4_003510 CC(C)(C)c1ccc(NC(=S)NCc2cccnc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P13 compound treatment 1.24204139E8 -2.45E7 -0.31 1.31882868E8 -2.49E7 -0.43 -0.5186 -0.9874 3178790 Maybridge4_003511 CN(C)C(=O)NC(Nc1cc(C)on1)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P14 compound treatment 1.18263295E8 -3.05E7 -0.38 1.19628762E8 -3.71E7 -0.64 -0.7196 -0.9705 1634696 Maybridge4_003512 OCN1N=C(CCC1=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P15 compound treatment 1.18606875E8 -3.01E7 -0.38 1.13141902E8 -4.36E7 -0.75 -0.7951 -0.9503 1538301 Maybridge4_003513 OC(=O)CCn1nc(Nc2ccccc2)n(c3ccccc3)c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P16 compound treatment 1.1206834E8 -3.67E7 -0.46 1.26032568E8 -3.07E7 -0.53 -0.697 -0.9978 3065050 Maybridge4_003514 COCc1nc(S)nc(O)c1Cc2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P17 compound treatment 1.19838517E8 -2.89E7 -0.36 1.27931709E8 -2.88E7 -0.49 -0.6051 -0.9886 1358448 Maybridge4_003515 COc1ccccc1C2CCN(CC2)C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P18 compound treatment 1.17300177E8 -3.14E7 -0.39 1.27232079E8 -2.95E7 -0.51 -0.6361 -0.9925 3065051 Maybridge4_003516 CC(C)(C)NC(=S)NCC1CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P19 compound treatment 1.12314881E8 -3.64E7 -0.46 1.24046271E8 -3.27E7 -0.56 -0.7189 -0.9949 1357507 Maybridge4_003517 Clc1ccc(Nc2ccc(nn2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P20 compound treatment 1.11794189E8 -3.69E7 -0.46 1.22269666E8 -3.45E7 -0.59 -0.745 -0.9929 1680143 Maybridge4_003518 Cc1cc(Nc2ccc(F)cc2)nc(SCc3c(Cl)cccc3Cl)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P21 compound treatment 1.21756142E8 -2.7E7 -0.34 1.30046726E8 -2.67E7 -0.46 -0.5625 -0.9891 1714479 Maybridge4_003519 CCOC(=O)N1CCN(CC(O)Cn2c(=O)n(C)c3ncn(C)c3c2=O)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P22 compound treatment 1.01550922E8 -4.72E7 -0.59 1.23411186E8 -3.33E7 -0.57 -0.8221 -0.9998 3178866 Maybridge4_003520 CCCC1=NN(C(=O)C1CC=C)S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P23 mock treatment 1.14218939E8 -3.45E7 -0.43 1.25504737E8 -3.12E7 -0.53 -0.6843 -0.9945 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2058 P24 mock treatment 1.22335181E8 -2.64E7 -0.33 1.36276329E8 -2.05E7 -0.35 -0.482 -0.9996 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A01 compound treatment 1.5292614E8 -8010000.0 -0.1 1.602439E8 1.14E7 0.2 0.067 0.3051 1585984 Maybridge4_003521 CC1=NN(C(=O)C2CC2)C(=O)C1Cc3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A02 compound treatment 1.10602668E8 -5.03E7 -0.63 1.14106682E8 -3.47E7 -0.59 -0.8669 -0.9995 1074928 Maybridge4_003522 S=c1cc(ss1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A03 compound treatment 1.51253674E8 -9680000.0 -0.12 1.56323438E8 7490000.0 0.13 0.0047 0.0268 3178867 Maybridge4_003523 Fc1ccc(N(C(=O)c2ccco2)C3=NCCCC(=O)S3)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A04 compound treatment 1.59415198E8 -1520000.0 -0.02 1.63943355E8 1.51E7 0.26 0.1694 0.6531 3065053 Maybridge4_003524 CN(C)C(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A05 compound treatment 1.62942517E8 2000000.0 0.03 1.56325101E8 7490000.0 0.13 0.1084 0.83 1513145 Maybridge4_003525 CCCc1nc(SCC(=O)c2ccc(Cl)cc2)nc(OC(=O)N(CC)CC)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A06 compound treatment 1.58039365E8 -2900000.0 -0.04 1.61046673E8 1.22E7 0.21 0.1221 0.5754 1235942 Maybridge4_003526 CC(C)(C)NC(=O)Nc1ccc2ccccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A07 compound treatment 1.63921141E8 2980000.0 0.04 1.65698894E8 1.69E7 0.29 0.2306 0.7921 1494176 Maybridge4_003527 Cc1cccc(NC(=S)Nc2ccccn2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A08 compound treatment 1.64240698E8 3300000.0 0.04 1.66475041E8 1.76E7 0.3 0.2428 0.7967 3065054 Maybridge4_003528 CNN1C(=O)c2cccc3cccc(C1=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A09 compound treatment 1.64616554E8 3680000.0 0.05 1.73062437E8 2.42E7 0.41 0.3259 0.781 1077258 Maybridge4_003529 COc1ccc(cc1)C(CC(=O)c2ccccc2)CC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A10 compound treatment 1.58375636E8 -2560000.0 -0.03 1.66481421E8 1.76E7 0.3 0.1909 0.6283 3065056 Maybridge4_003530 Brc1ccc(cc1)C(=O)CC(CC(=O)c2ccc(Br)cc2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A11 compound treatment 1.66010553E8 5070000.0 0.06 1.73867893E8 2.5E7 0.43 0.348 0.8033 1076053 Maybridge4_003531 CN(C)CN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A12 compound treatment 1.55802264E8 -5140000.0 -0.06 1.5610458E8 7270000.0 0.12 0.0424 0.3028 1711456 Maybridge4_003532 O=C1CSC(N1c2cccnc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A13 compound treatment 1.58038657E8 -2900000.0 -0.04 1.46882709E8 -1950000.0 -0.03 -0.0494 -0.9991 3065058 Maybridge4_003533 Cc1c(C)c(NC(=O)/C=C/C(=O)O)c(C)c(C)c1NC(=O)/C=C/C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A14 compound treatment 1.50617913E8 -1.03E7 -0.13 1.51345752E8 2510000.0 0.04 -0.0612 -0.4484 3065084 Maybridge4_003534 CCc1ccc(cc1)n2nn[nH]c2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A15 compound treatment 1.51437591E8 -9500000.0 -0.12 1.52361277E8 3530000.0 0.06 -0.0416 -0.3114 1012391 Maybridge4_003535 Clc1cccc(NC(=S)Nc2cccc(Cl)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A16 compound treatment 1.62666543E8 1730000.0 0.02 1.57551383E8 8720000.0 0.15 0.1208 0.8014 3065085 Maybridge4_003536 Cc1oc2ccccc2c1CNC(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A17 compound treatment 1.62337977E8 1400000.0 0.02 1.55801363E8 6970000.0 0.12 0.0967 0.8026 1164445 Maybridge4_003537 CCc1ccc(cc1)N2C(=O)CC(Sc3ccccc3N)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A18 compound treatment 1.63547771E8 2610000.0 0.03 1.63103701E8 1.43E7 0.24 0.1958 0.7948 3065086 Maybridge4_003538 C/C(=N\CCc1ccc(Cl)cc1)/c2ccccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A19 compound treatment 1.70328832E8 9390000.0 0.12 1.62656615E8 1.38E7 0.24 0.2506 0.9482 1020973 Maybridge4_003539 CC1(NC(=O)NC1=O)C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A20 compound treatment 1.69312738E8 8370000.0 0.11 1.9212368E8 4.33E7 0.74 0.5982 0.7994 3065087 Maybridge4_003540 Cc1ccc(NC(=C2C(=O)c3ccccc3C2=O)C#N)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A21 compound treatment 1.69239314E8 8300000.0 0.1 1.78757853E8 2.99E7 0.51 0.4358 0.8338 3065088 Maybridge4_003541 CC(=O)Nc1nnc(o1)c2c(C)onc2c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A22 compound treatment 1.64327339E8 3390000.0 0.04 1.65212235E8 1.64E7 0.28 0.2283 0.8051 3065089 Maybridge4_003542 Cc1cc(SCc2ccc(F)cc2)c(C)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A23 mock treatment 1.54460905E8 -6480000.0 -0.08 1.92227634E8 4.34E7 0.74 0.4678 0.626 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 A24 mock treatment 1.49930089E8 -1.1E7 -0.14 1.65439251E8 1.66E7 0.28 0.1033 0.327 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B01 compound treatment 1.83906552E8 2.3E7 0.29 1.5224953E8 3410000.0 0.06 0.2451 0.8335 1186435 Maybridge4_003543 CCc1ccc(O)c(c1)C2(O)C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B02 compound treatment 1.17848578E8 -4.31E7 -0.54 1.13830782E8 -3.5E7 -0.6 -0.8059 -0.9987 1389708 Maybridge4_003544 CCOc1ccc(NC23SCC(=O)C3CCc4ccccc42)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B03 compound treatment 1.8268572E8 2.17E7 0.27 1.53321583E8 4490000.0 0.08 0.2472 0.8722 1565816 Maybridge4_003545 CC(C)(C)c1ccc(cc1)C(=O)Oc2ccccc2CCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B04 compound treatment 1.44149136E8 -1.68E7 -0.21 1.34228369E8 -1.46E7 -0.25 -0.3257 -0.9964 3178868 Maybridge4_003546 CCSC(=S)c1c(C)nn(c1O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B05 compound treatment 1.92460821E8 3.15E7 0.4 1.7128498E8 2.24E7 0.38 0.5513 0.9999 1315983 Maybridge4_003547 Clc1ccc(NC(C#N)c2ccccc2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B06 compound treatment 1.76487561E8 1.55E7 0.2 1.41680774E8 -7160000.0 -0.12 0.0513 0.2228 1049908 Maybridge4_003548 Fc1ccc(cc1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B07 compound treatment 1.75610506E8 1.47E7 0.18 1.17299479E8 -3.15E7 -0.54 -0.2516 -0.4411 3178869 Maybridge4_003549 NC(=S)Nc1ccccc1OC(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B08 compound treatment 1.77760058E8 1.68E7 0.21 1.58036331E8 9200000.0 0.16 0.2606 0.9896 3178870 Maybridge4_003550 COc1ccc(cc1)C(=O)NCc2c(C)onc2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B09 compound treatment 1.66566267E8 5630000.0 0.07 1.58386342E8 9550000.0 0.16 0.1655 0.9295 3065091 Maybridge4_003551 CC1CN(CC(C)O1)c2ccccc2OC(=O)Nc3ccc(OC(F)(F)F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B10 compound treatment 1.70394945E8 9460000.0 0.12 1.29017617E8 -1.98E7 -0.34 -0.156 -0.4341 3178871 Maybridge4_003552 Clc1ccc2nc(NC(=O)C3CN(C3)C(c4ccccc4)c5ccccc5)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B11 compound treatment 1.80333806E8 1.94E7 0.24 1.06276807E8 -4.26E7 -0.73 -0.3431 -0.4467 3178872 Maybridge4_003553 COc1ccc2cc(ccc2c1)C(C)C(=O)Nc3ccc(OC(F)(F)F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B12 compound treatment 1.62773397E8 1830000.0 0.02 1.67068261E8 1.82E7 0.31 0.237 0.7572 3065092 Maybridge4_003554 CCc1ccnc(NC(=O)CC2(CC(=O)O)CCCCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B13 compound treatment 1.607316E8 -207000.0 0.0 1.83110324E8 3.43E7 0.59 0.413 0.704 1734850 Maybridge4_003555 COc1cc2N3C(=O)c4ccccc4C3(O)OC(=O)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B14 compound treatment 1.64247855E8 3310000.0 0.04 1.56909535E8 8070000.0 0.14 0.1271 0.8806 3065093 Maybridge4_003556 Cc1nn(nc1CNC(=O)c2cc(F)cc3COCOc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B15 compound treatment 1.59374353E8 -1560000.0 -0.02 8.7205649E7 -6.16E7 -1.05 -0.7599 -0.7201 3178873 Maybridge4_003557 NNC(=S)NCc1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B16 compound treatment 1.65792098E8 4850000.0 0.06 1.7546372E8 2.66E7 0.46 0.3654 0.7945 3178874 Maybridge4_003558 Cc1nn(C)c2sc(cc12)C(=O)N(Cc3ccccn3)Cc4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B17 compound treatment 1.62486015E8 1550000.0 0.02 1.52382615E8 3550000.0 0.06 0.0567 0.8889 3065094 Maybridge4_003559 CN/1N=C(CS\C1=N\c2ccccc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B18 compound treatment 1.534649E8 -7470000.0 -0.09 1.13045382E8 -3.58E7 -0.61 -0.4995 -0.8059 3178875 Maybridge4_003560 O=C(Nc1ccc(cc1)N2CCOCC2)c3cnc4ccccc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B19 compound treatment 1.59848868E8 -1090000.0 -0.01 1.07390471E8 -4.14E7 -0.71 -0.5113 -0.7206 1661129 Maybridge4_003561 Cc1ccc(CNC(=S)NCCO)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B20 compound treatment 1.52803392E8 -8140000.0 -0.1 1.74471812E8 2.56E7 0.44 0.2381 0.5286 3178876 Maybridge4_003562 CN1CCN(CC1)c2ccc(CNC(=O)c3ccc4OCCOc4c3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B21 compound treatment 1.47934684E8 -1.3E7 -0.16 1.73326341E8 2.45E7 0.42 0.1811 0.4026 1246483 Maybridge4_003563 COc1ccc(cc1)C2C3CCc4ccccc4C3=NN2CCOC(=O)C5CC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B22 compound treatment 1.49227282E8 -1.17E7 -0.15 1.68489603E8 1.97E7 0.34 0.134 0.365 1407515 Maybridge4_003564 CCOC(=O)C1CCN(CC1)C(=O)CN2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B23 mock treatment 1.46037479E8 -1.49E7 -0.19 1.82231457E8 3.34E7 0.57 0.2721 0.4523 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 B24 mock treatment 1.41840672E8 -1.91E7 -0.24 1.62409992E8 1.36E7 0.23 -0.0051 -0.0153 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C01 compound treatment 1.44955392E8 -1.6E7 -0.2 1.36424782E8 -1.24E7 -0.21 -0.292 -0.9996 3178877 Maybridge4_003565 CCCc1cc(O)nc(NC(=N)Nc2cccc(c2)C(F)(F)F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C02 compound treatment 1.529395E8 -8000000.0 -0.1 1.30315114E8 -1.85E7 -0.32 -0.2951 -0.8875 3065097 Maybridge4_003566 O=C1N(Nc2ccc(cc2)N3CCOCC3)C(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C03 compound treatment 1.5344866E8 -7490000.0 -0.09 1.32953894E8 -1.59E7 -0.27 -0.2587 -0.8993 3065098 Maybridge4_003567 CCCc1nc(SCC2CC2)nc(O)c1CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C04 compound treatment 1.60653303E8 -285000.0 0.0 1.40185811E8 -8650000.0 -0.15 -0.1072 -0.724 3178878 Maybridge4_003568 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccnn2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C05 compound treatment 1.58912501E8 -2030000.0 -0.03 1.38611867E8 -1.02E7 -0.18 -0.1417 -0.8014 3178879 Maybridge4_003569 FC(F)(F)c1ccc(NC(=S)NC(=O)/C=C/c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C06 compound treatment 1.49763748E8 -1.12E7 -0.14 1.33253804E8 -1.56E7 -0.27 -0.2877 -0.9549 1525321 Maybridge4_003570 CCc1ccc(NC(=S)Nc2ccccc2C(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C07 compound treatment 1.48368938E8 -1.26E7 -0.16 1.37483969E8 -1.14E7 -0.19 -0.2489 -0.9946 1218939 Maybridge4_003571 NNC(=S)NC1CCCCCCCCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C08 compound treatment 1.42215276E8 -1.87E7 -0.23 1.32449061E8 -1.64E7 -0.28 -0.3644 -0.9961 3065100 Maybridge4_003572 C(N1C2CCCCCN2c3ccccc13)c4ccncc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C09 compound treatment 1.45716288E8 -1.52E7 -0.19 1.36661249E8 -1.22E7 -0.21 -0.2824 -0.999 3178880 Maybridge4_003573 O=C(CC(CC(=O)c1ccccc1)c2cccc3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C10 compound treatment 1.473896E8 -1.35E7 -0.17 1.26791231E8 -2.2E7 -0.38 -0.387 -0.9351 3178881 Maybridge4_003574 Cn1cccc1C(=S)NC(=O)Nc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C11 compound treatment 1.36520366E8 -2.44E7 -0.31 1.30516764E8 -1.83E7 -0.31 -0.4383 -0.9999 3065101 Maybridge4_003575 CC1CC(CC(C)(C)C1)NC(=S)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C12 compound treatment 1.41012712E8 -1.99E7 -0.25 1.26797056E8 -2.2E7 -0.38 -0.4435 -0.98 3065130 Maybridge4_003576 Clc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C13 compound treatment 1.40962113E8 -2.0E7 -0.25 1.233956E8 -2.54E7 -0.44 -0.4851 -0.9656 1084590 Maybridge4_003577 FC(F)(F)c1cccc(c1)n2c(=O)c3ccccc3[nH]c2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C14 compound treatment 1.34202366E8 -2.67E7 -0.34 1.18146485E8 -3.07E7 -0.53 -0.6086 -0.9765 3065131 Maybridge4_003578 COc1ccc(Nc2cc(ccc2Cl)C(F)(F)F)c(c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C15 compound treatment 1.4405165E8 -1.69E7 -0.21 1.35433262E8 -1.34E7 -0.23 -0.312 -0.9992 1657408 Maybridge4_003579 CCOc1ccc(cc1)n2c(=O)c3cc4c(=O)n(c5ccc(OCC)cc5)c(=O)c4cc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C16 compound treatment 1.33146191E8 -2.78E7 -0.35 1.35802512E8 -1.3E7 -0.22 -0.4043 -0.9767 3065132 Maybridge4_003580 C/C(=N\CCc1c[nH]c2ccccc12)/c3ccccc3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C17 compound treatment 1.2754237E8 -3.34E7 -0.42 1.16968354E8 -3.19E7 -0.55 -0.682 -0.9915 3065134 Maybridge4_003581 CCc1ccc(NC2=NCCS2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C18 compound treatment 1.28652597E8 -3.23E7 -0.41 1.21499602E8 -2.73E7 -0.47 -0.6173 -0.9974 3065135 Maybridge4_003582 Clc1ccc(CCn2nn[nH]c2=S)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C19 compound treatment 1.30575264E8 -3.04E7 -0.38 1.30490734E8 -1.83E7 -0.31 -0.4914 -0.9954 1919115 Maybridge4_003583 COc1ccc(CC/N=C/c2ccccc2O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C20 compound treatment 1.15622106E8 -4.53E7 -0.57 1.15153087E8 -3.37E7 -0.58 -0.8097 -1.0 3065136 Maybridge4_003584 O=C1C(=C(Nc2cccnc2)C#N)C(=O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C21 compound treatment 1.34305997E8 -2.66E7 -0.33 1.22102627E8 -2.67E7 -0.46 -0.5598 -0.988 1317332 Maybridge4_003585 CC(C)c1cccc(C(C)C)c1NC(=S)Nc2cccc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C22 compound treatment 1.26937182E8 -3.4E7 -0.43 1.01429689E8 -4.74E7 -0.81 -0.8754 -0.9549 3065137 Maybridge4_003586 Clc1ccc(s1)C(=O)CC2OC(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C23 mock treatment 1.3981119E8 -2.11E7 -0.27 1.32062801E8 -1.68E7 -0.29 -0.3904 -0.9992 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 C24 mock treatment 1.43123299E8 -1.78E7 -0.22 1.42856195E8 -5980000.0 -0.1 -0.2304 -0.9373 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D01 compound treatment 1.57079997E8 -3860000.0 -0.05 1.32938635E8 -1.59E7 -0.27 -0.2266 -0.82 1200638 Maybridge4_003587 Cc1ccc(cc1)N2C(C(=O)c3ccc(C)cc3O)c4ccccc4C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D02 compound treatment 1.53442144E8 -7500000.0 -0.09 1.54200423E8 5360000.0 0.09 -0.0016 -0.0119 1391574 Maybridge4_003588 COc1ccc(Cc2nnc(N)o2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D03 compound treatment 1.51143333E8 -9800000.0 -0.12 1.34694848E8 -1.41E7 -0.24 -0.2581 -0.9506 1057870 Maybridge4_003589 O=C1CC(=O)N(Cc2ccccc2)C(=O)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D04 compound treatment 3.9195531E8 2.31E8 2.9 3.15905368E8 1.67E8 2.86 4.0714 1.0 1006014 Maybridge4_003590 OC(=O)c1cc(O)nc(O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D05 compound treatment 1.57721719E8 -3220000.0 -0.04 1.55989724E8 7150000.0 0.12 0.0581 0.4503 3178961 Maybridge4_003591 Cc1ccc(F)cc1N2C(=O)COCC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D06 compound treatment 1.59379787E8 -1560000.0 -0.02 1.42627123E8 -6210000.0 -0.11 -0.089 -0.8234 3065138 Maybridge4_003592 N[C@@H](CC1CCCCC1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D07 compound treatment 1.69349992E8 8410000.0 0.11 1.40807243E8 -8030000.0 -0.14 -0.0226 -0.1302 3178962 Maybridge4_003593 OCC1(CO)CSC(=N1)Nc2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D08 compound treatment 1.63490359E8 2550000.0 0.03 1.46205253E8 -2630000.0 -0.05 -0.0092 -0.1666 3065139 Maybridge4_003594 Cc1onc(c1CNC(=O)C2CCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D09 compound treatment 1.53445918E8 -7490000.0 -0.09 9.0022964E7 -5.88E7 -1.01 -0.7783 -0.7698 3178963 Maybridge4_003595 FC(F)(F)Oc1ccc(NC(=O)Oc2ccccc2N3CCOCC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D10 compound treatment 1.56517963E8 -4420000.0 -0.06 1.38272492E8 -1.06E7 -0.18 -0.1671 -0.8834 3178964 Maybridge4_003596 O=C(NCc1cc2ccccc2s1)C3CN(C3)C(c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D11 compound treatment 1.73064872E8 1.21E7 0.15 1.5526846E8 6430000.0 0.11 0.1854 0.9874 1719612 Maybridge4_003597 O=C1CC2(CCCc3ccccc32)C(=O)N1CN4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D12 compound treatment 1.47508811E8 -1.34E7 -0.17 1.13733527E8 -3.51E7 -0.6 -0.544 -0.8717 3178965 Maybridge4_003598 Fc1cc(NC(=O)Nc2ccc(cc2)c3nc4ccccc4s3)c5OCOCc5c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D13 compound treatment 1.75891825E8 1.5E7 0.19 1.58586448E8 9750000.0 0.17 0.2507 0.9983 3065140 Maybridge4_003599 CCCC(/N=C/c1cc(Cl)ccc1O)/N=C/c2cc(Cl)ccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D14 compound treatment 1.52225142E8 -8710000.0 -0.11 1.39907505E8 -8930000.0 -0.15 -0.1854 -0.9865 3178966 Maybridge4_003600 CC(C)c1ccc(NC(=O)c2cc(F)cc3COCOc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D15 compound treatment 1.59932423E8 -1010000.0 -0.01 1.4786026E8 -976000.0 -0.02 -0.0207 -0.9905 3065142 Maybridge4_003601 Fc1ccc(Cn2nn[nH]c2=S)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D16 compound treatment 1.58277412E8 -2660000.0 -0.03 1.45397407E8 -3440000.0 -0.06 -0.0652 -0.9639 3178967 Maybridge4_003602 Cc1cc(CNC(=O)c2cc(C)n(C)n2)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D17 compound treatment 1.47652344E8 -1.33E7 -0.17 1.41469298E8 -7370000.0 -0.13 -0.207 -0.9905 1581411 Maybridge4_003603 COc1ccc(NC(=S)N2CCCC(=N2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D18 compound treatment 1.53250637E8 -7690000.0 -0.1 1.52130448E8 3290000.0 0.06 -0.0283 -0.2534 3065143 Maybridge4_003604 COc1ccc(CC(=O)Nc2ccc(cc2)N3CCOCC3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D19 compound treatment 1.53991441E8 -6950000.0 -0.09 9.0063427E7 -5.88E7 -1.01 -0.773 -0.7655 3178968 Maybridge4_003605 CN(C)C(=S)NCCC1=CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D20 compound treatment 1.57060197E8 -3880000.0 -0.05 1.42075764E8 -6760000.0 -0.12 -0.1162 -0.9259 3065144 Maybridge4_003606 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3ccc4OCCc4c3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D21 compound treatment 1.43853813E8 -1.71E7 -0.21 1.34947148E8 -1.39E7 -0.24 -0.3197 -0.9987 3178969 Maybridge4_003607 CSc1ccc(cc1)C2C3CCCc4ccccc4C3=NN2CCO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D22 compound treatment 1.5531823E8 -5620000.0 -0.07 1.39171585E8 -9660000.0 -0.17 -0.1668 -0.9277 1607790 Maybridge4_003608 Fc1ccc(NC(=O)CN2C(=O)c3ccccc3C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D23 mock treatment 1.47294339E8 -1.36E7 -0.17 1.37813611E8 -1.1E7 -0.19 -0.2544 -0.9988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 D24 mock treatment 1.37092373E8 -2.38E7 -0.3 1.2778607E8 -2.1E7 -0.36 -0.4663 -0.9957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E01 compound treatment 1.28928322E8 -3.2E7 -0.4 1.233036E8 -2.55E7 -0.44 -0.593 -0.9991 1514931 Maybridge4_003609 CC(C)(C)C(=O)Nc1nc(NC(=O)C(C)(C)C)nc(n1)c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E02 compound treatment 1.38699159E8 -2.22E7 -0.28 1.30156059E8 -1.87E7 -0.32 -0.4234 -0.9977 3178970 Maybridge4_003610 CC1CC(CC(C)(C)C1)NC(=S)Nc2cc(C)ccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E03 compound treatment 1.45759065E8 -1.52E7 -0.19 1.26398541E8 -2.24E7 -0.38 -0.4062 -0.9476 3065145 Maybridge4_003611 Cc1cccc(C)c1NC(=S)N2CCCC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E04 compound treatment 1.52165539E8 -8770000.0 -0.11 1.31734906E8 -1.71E7 -0.29 -0.2848 -0.9107 3178971 Maybridge4_003612 Oc1ccccc1/C=N/c2ccccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E05 compound treatment 1.46527333E8 -1.44E7 -0.18 1.43082955E8 -5750000.0 -0.1 -0.1975 -0.9592 3178972 Maybridge4_003613 Oc1nc(S)nc(c1Cc2ccc(Cl)c(Cl)c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E06 compound treatment 1.54686625E8 -6250000.0 -0.08 1.43945032E8 -4890000.0 -0.08 -0.1147 -0.9995 3065146 Maybridge4_003614 CCOc1ccc(NC(=S)NC(c2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E07 compound treatment 1.42515263E8 -1.84E7 -0.23 1.40926506E8 -7910000.0 -0.14 -0.2592 -0.9675 3178973 Maybridge4_003615 Cc1cccc(C)c1NC2=NCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E08 compound treatment 1.5424461E8 -6690000.0 -0.08 1.39325332E8 -9510000.0 -0.16 -0.1745 -0.9526 3065190 Maybridge4_003616 COc1cc(CN2C3CCCCCN3c4ccccc24)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E09 compound treatment 1.49473331E8 -1.15E7 -0.14 1.39607167E8 -9230000.0 -0.16 -0.2134 -0.9989 1023038 Maybridge4_003617 CN(C)C(=S)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E10 compound treatment 1.29135249E8 -3.18E7 -0.4 1.01320499E8 -4.75E7 -0.81 -0.8572 -0.9462 3065191 Maybridge4_003618 S=c1[nH]nnn1C2CC3CC2C4C=CCC34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E11 compound treatment 1.69990275E8 9050000.0 0.11 9.6347809E7 -5.25E7 -0.9 -0.555 -0.6129 3065192 Maybridge4_003619 C(=N/c1ccccc1)\c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E12 compound treatment 1.57637459E8 -3300000.0 -0.04 1.61031253E8 1.22E7 0.21 0.1183 0.556 3065193 Maybridge4_003620 CC(C)(C)c1ccc(/N=C/c2ccccc2O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E13 compound treatment 1.60247171E8 -691000.0 -0.01 1.37096636E8 -1.17E7 -0.2 -0.1482 -0.7369 1597004 Maybridge4_003621 CN(C)C(=S)Nc1ccc(cc1)S(=O)(=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E14 compound treatment 1.50193629E8 -1.07E7 -0.13 1.55022772E8 6190000.0 0.11 -0.0204 -0.1191 3065194 Maybridge4_003622 CCCNC(=O)OCN1C(=O)c2ccc(N)cc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E15 compound treatment 1.63235732E8 2300000.0 0.03 1.48598967E8 -237000.0 0.0 0.0175 0.6017 3065195 Maybridge4_003623 Cc1cccc(NC2=NCCCS2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E16 compound treatment 1.64249072E8 3310000.0 0.04 1.46150391E8 -2690000.0 -0.05 -0.0031 -0.0507 3178974 Maybridge4_003624 O=C1CSC(N1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E17 compound treatment 1.48526265E8 -1.24E7 -0.16 1.53685904E8 4850000.0 0.08 -0.0514 -0.2913 3065196 Maybridge4_003625 COc1cc(NC(=S)N(C)C)c(OC)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E18 compound treatment 1.60102996E8 -835000.0 -0.01 1.45387941E8 -3450000.0 -0.06 -0.0491 -0.8198 1132507 Maybridge4_003626 NNC(=S)NCCc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E19 compound treatment 1.30157345E8 -3.08E7 -0.39 1.20402805E8 -2.84E7 -0.49 -0.6172 -0.9934 3178975 Maybridge4_003627 Oc1ccc2ccccc2c1/C=N/Cc3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E20 compound treatment 1.55563589E8 -5370000.0 -0.07 1.58974207E8 1.01E7 0.17 0.075 0.403 1203485 Maybridge4_003628 CC(CC(=O)O)CC(=O)Nc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E21 compound treatment 9.8968147E7 -6.2E7 -0.78 1.38133388E8 -1.07E7 -0.18 -0.6792 -0.8505 3178976 Maybridge4_003629 CSc1cccc(NC(=S)NN(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E22 compound treatment 1.54247437E8 -6690000.0 -0.08 1.21825314E8 -2.7E7 -0.46 -0.3863 -0.822 1385701 Maybridge4_003630 CC(C)(CC(=O)O)CC(=O)Nc1ccc(Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E23 mock treatment 1.20179684E8 -4.08E7 -0.51 1.38869665E8 -9970000.0 -0.17 -0.4822 -0.8946 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 E24 mock treatment 1.46877489E8 -1.41E7 -0.18 1.32226405E8 -1.66E7 -0.28 -0.3258 -0.9736 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F01 compound treatment 1.58443067E8 -2500000.0 -0.03 1.47338565E8 -1500000.0 -0.03 -0.0403 -0.9951 1225773 Maybridge4_003631 Cc1cc(C)c(O)c(c1)C2(O)C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F02 compound treatment 1.43577496E8 -1.74E7 -0.22 9.7788609E7 -5.1E7 -0.87 -0.7719 -0.8571 1310128 Maybridge4_003632 OCCn1nc(O)ccc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F03 compound treatment 1.57449744E8 -3490000.0 -0.04 9.4187353E7 -5.46E7 -0.94 -0.6924 -0.7394 1400202 Maybridge4_003633 O=c1n(Cc2cccnc2)c(=S)[nH]c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F04 compound treatment 1.57064882E8 -3870000.0 -0.05 1.25002758E8 -2.38E7 -0.41 -0.3228 -0.7858 1055139 Maybridge4_003634 C(CC1CCNCC1)CC2CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F05 compound treatment 1.52136316E8 -8800000.0 -0.11 1.4259924E8 -6240000.0 -0.11 -0.1536 -0.9999 1205535 Maybridge4_003635 CN1N=C2C(CCc3ccccc23)C1c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F06 compound treatment 1.54283786E8 -6650000.0 -0.08 1.02333836E8 -4.65E7 -0.8 -0.6219 -0.777 1475761 Maybridge4_003636 OC(=O)C1CCN(CC1)C(=O)OCC2c3ccccc3-c4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F07 compound treatment 1.61670852E8 732000.0 0.01 1.5649334E8 7660000.0 0.13 0.0992 0.7548 3065197 Maybridge4_003637 COc1ccccc1NC2=NC(CO)(CO)CS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F08 compound treatment 1.49869258E8 -1.11E7 -0.14 1.45833771E8 -3000000.0 -0.05 -0.1345 -0.9086 3178977 Maybridge4_003638 Cc1onc(c1CNS(=O)(=O)c2cccc(Cl)c2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F09 compound treatment 1.74565939E8 1.36E7 0.17 9.9549739E7 -4.93E7 -0.84 -0.4757 -0.5526 1679129 Maybridge4_003639 OCCn1c(=O)[nH]c2ccsc2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F10 compound treatment 1.50181547E8 -1.08E7 -0.13 9.6684556E7 -5.22E7 -0.89 -0.7267 -0.8048 3178978 Maybridge4_003640 O=C(Nc1ccc(cc1)n2cncn2)c3ccccc3N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F11 compound treatment 1.67900486E8 6960000.0 0.09 1.29634022E8 -1.92E7 -0.33 -0.1707 -0.5018 1432542 Maybridge4_003641 OC1(NC(=O)Cc2ccccc2Cl)C(=O)c3ccccc3C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F12 compound treatment 1.6927138E8 8330000.0 0.1 1.39731768E8 -9100000.0 -0.16 -0.0363 -0.1933 3178979 Maybridge4_003642 CSc1c(c(N)nn1C(=O)C2CCC2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F13 compound treatment 1.56440143E8 -4500000.0 -0.06 1.09360739E8 -3.95E7 -0.68 -0.5177 -0.7635 1512720 Maybridge4_003643 CN1OC(COC(=O)c2cc(Cl)cc(Cl)c2)CC31C4CC5CC(C4)CC3C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F14 compound treatment 1.49484425E8 -1.15E7 -0.14 1.42577609E8 -6260000.0 -0.11 -0.1774 -0.9895 3065199 Maybridge4_003644 NC(=O)c1ccc(NC(=O)c2cccc3OCCCOc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F15 compound treatment 1.5792054E8 -3020000.0 -0.04 1.44846544E8 -3990000.0 -0.07 -0.0751 -0.9613 3065200 Maybridge4_003645 Cc1ccc2nc(oc2c1)c3ccc(cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F16 compound treatment 1.53333656E8 -7600000.0 -0.1 8.9309487E7 -5.95E7 -1.02 -0.788 -0.7699 3178980 Maybridge4_003646 Cc1cc(nn1C)C(=O)NCC2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F17 compound treatment 1.38752759E8 -2.22E7 -0.28 1.4776651E8 -1070000.0 -0.02 -0.2097 -0.752 3065201 Maybridge4_003647 Cc1ccc(NC(=S)N2CCCC(=N2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F18 compound treatment 1.536311E8 -7310000.0 -0.09 1.42643198E8 -6190000.0 -0.11 -0.1398 -0.9974 3178981 Maybridge4_003648 COc1ccc(CC(=O)Nc2ccc(cc2)c3cnco3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F19 compound treatment 1.6076723E8 -171000.0 0.0 8.4569993E7 -6.43E7 -1.1 -0.7794 -0.7085 1597585 Maybridge4_003649 COc1ccc(CNC(=S)NCCO)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F20 compound treatment 1.5552382E8 -5410000.0 -0.07 9.0963173E7 -5.79E7 -0.99 -0.7485 -0.7538 3065202 Maybridge4_003650 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3sc(C)nc3C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F21 compound treatment 1.39805453E8 -2.11E7 -0.27 1.44327908E8 -4510000.0 -0.08 -0.242 -0.8766 2107603 Maybridge4_003651 O=C1/C(=C/c2ccccc2)/CCCc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F22 compound treatment 1.50243193E8 -1.07E7 -0.13 1.57435238E8 8600000.0 0.15 0.0092 0.0463 3179070 Maybridge4_003652 O=C1NCCCCC1NS(=O)(=O)c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F23 mock treatment 1.5110928E8 -9830000.0 -0.12 1.51085245E8 2250000.0 0.04 -0.06 -0.4642 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 F24 mock treatment 1.44406328E8 -1.65E7 -0.21 1.3788591E8 -1.09E7 -0.19 -0.2792 -0.9987 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G01 compound treatment 1.53624102E8 -7310000.0 -0.09 1.53616381E8 4780000.0 0.08 -0.007 -0.0571 3065203 Maybridge4_003653 CC(C)(C)C(=O)Nc1nc(NC(=O)C(C)(C)C)nc(n1)c2ccccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G02 compound treatment 1.74320557E8 1.34E7 0.17 1.67221282E8 1.84E7 0.31 0.3412 0.9567 3179071 Maybridge4_003654 Fc1cccc(NC(=S)NCc2ccc3OCOc3c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G03 compound treatment 1.64763836E8 3830000.0 0.05 1.61793686E8 1.3E7 0.22 0.1908 0.8406 1323302 Maybridge4_003655 CCCc1nc(nc(OC(=O)N(C)C)c1Cc2c(F)cccc2Cl)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G04 compound treatment 1.80857825E8 1.99E7 0.25 1.77017501E8 2.82E7 0.48 0.5178 0.9531 3065204 Maybridge4_003656 COC(=C(C#N)C#N)c1c(C)onc1c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G05 compound treatment 1.82996936E8 2.21E7 0.28 1.82243739E8 3.34E7 0.57 0.6 0.9445 3065205 Maybridge4_003657 CC(C)(C)C(=O)Cn1nnc(n1)c2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G06 compound treatment 1.89314904E8 2.84E7 0.36 1.9548035E8 4.66E7 0.8 0.8163 0.9338 3179072 Maybridge4_003658 COC(=O)c1cc(NC(=O)/C=C/C(=O)O)ccc1N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G07 compound treatment 1.84050448E8 2.31E7 0.29 1.84686858E8 3.59E7 0.61 0.639 0.9414 3065206 Maybridge4_003659 Sc1nnc(Nc2ccccc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G08 compound treatment 1.88492247E8 2.76E7 0.35 2.15219863E8 6.64E7 1.14 1.0479 0.8823 3065300 Maybridge4_003660 CC1(C)NN(C(=O)N1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G09 compound treatment 1.92257099E8 3.13E7 0.39 1.98349006E8 4.95E7 0.85 0.8771 0.9389 1076488 Maybridge4_003661 CCOc1ccc(cc1)N2CSC(=S)N(C2)c3ccc(OCC)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G10 compound treatment 1.94550327E8 3.36E7 0.42 1.85148534E8 3.63E7 0.62 0.7377 0.9821 3065240 Maybridge4_003662 CC(C)N(Cc1ccccc1)C(=S)Nc2ccc(cc2)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G11 compound treatment 2.01472595E8 4.05E7 0.51 1.94142106E8 4.53E7 0.78 0.9079 0.979 3065241 Maybridge4_003663 OCCNC(=S)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G12 compound treatment 1.90521896E8 2.96E7 0.37 2.14415386E8 6.56E7 1.12 1.0562 0.8933 3065242 Maybridge4_003664 CC(C)(C)C(=O)Nc1ccc(cc1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G13 compound treatment 1.70995302E8 1.01E7 0.13 1.60553573E8 1.17E7 0.2 0.231 0.975 3065243 Maybridge4_003665 Cc1ccc2[nH]c(=S)n(C3CC4CC3C=C4)c(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G14 compound treatment 1.93149267E8 3.22E7 0.4 1.85456067E8 3.66E7 0.63 0.729 0.9774 3065244 Maybridge4_003666 CC1(C)CC(=O)C=C(C1)NC(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G15 compound treatment 1.93894254E8 3.3E7 0.41 1.77434203E8 2.86E7 0.49 0.6385 0.9965 3482133 Maybridge4_003667 CC(C)C(NS(=O)(=O)c1ccccc1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G16 compound treatment 1.15155694E8 -4.58E7 -0.57 1.17874071E8 -3.1E7 -0.53 -0.7809 -0.9992 3065245 Maybridge4_003668 Cc1ccc(cc1Cl)N2C(=O)N(C(=N)C2=S)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G17 compound treatment 1.52559026E8 -8380000.0 -0.11 1.48729574E8 -106000.0 0.0 -0.0756 -0.7192 3179073 Maybridge4_003669 Cc1c(C)c(C)c(CSc2cccc(NC(=O)/C=C/C(=O)O)c2)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G18 compound treatment 1.87316475E8 2.64E7 0.33 1.6124716E8 1.24E7 0.21 0.3842 0.9771 3065246 Maybridge4_003670 CC1=CCC2C(C1)C(=O)N(C2=O)c3ccc(cc3)C4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G19 compound treatment 1.65828756E8 4890000.0 0.06 1.59791568E8 1.1E7 0.19 0.176 0.8919 3179074 Maybridge4_003671 CN(CC(=O)O)C(=S)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G20 compound treatment 1.7412167E8 1.32E7 0.17 1.70131579E8 2.13E7 0.36 0.3747 0.9361 3179075 Maybridge4_003672 CSc1ccc(/C=N/n2c(=O)oc3ccccc3c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G21 compound treatment 1.7627658E8 1.53E7 0.19 1.7030172E8 2.15E7 0.37 0.3959 0.9544 3065247 Maybridge4_003673 CN(C)NC(=S)Nc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G22 compound treatment 2.07863147E8 4.69E7 0.59 1.74191809E8 2.54E7 0.43 0.7232 0.9888 1356260 Maybridge4_003674 N#Cc1ccc(cc1)C(N2CCSCC2)N3CCSCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G23 mock treatment 1.92152177E8 3.12E7 0.39 1.69420612E8 2.06E7 0.35 0.526 0.9986 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 G24 mock treatment 1.81302223E8 2.04E7 0.26 1.76740785E8 2.79E7 0.48 0.5184 0.957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H01 compound treatment 2.00472906E8 3.95E7 0.5 1.70050842E8 2.12E7 0.36 0.6075 0.9883 3065248 Maybridge4_003675 Clc1cccc(Cl)c1CSCc2cc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H02 compound treatment 2.01534739E8 4.06E7 0.51 1.67066467E8 1.82E7 0.31 0.5808 0.9724 1495324 Maybridge4_003676 CSCC(O)Cn1nc(O)ccc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H03 compound treatment 2.07029461E8 4.61E7 0.58 1.65743793E8 1.69E7 0.29 0.6135 0.9488 3065250 Maybridge4_003677 CN(C)/C=C/1\C(=O)N(C)N=C1c2ccccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H04 compound treatment 1.95285562E8 3.43E7 0.43 1.2360066E8 -2.52E7 -0.43 -8.0E-4 -0.0013 3179076 Maybridge4_003678 NC(=N)c1ccc(cc1)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H05 compound treatment 2.03902564E8 4.3E7 0.54 1.67640467E8 1.88E7 0.32 0.6087 0.9696 3065251 Maybridge4_003679 NC1=C(C#N)C(C#N)(C#N)C2CCCC(=C21)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H06 compound treatment 1.35666494E8 -2.53E7 -0.32 1.56915701E8 8080000.0 0.14 -0.1264 -0.3654 3179077 Maybridge4_003680 CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H07 compound treatment 2.01567787E8 4.06E7 0.51 1.72145913E8 2.33E7 0.4 0.6425 0.9927 3179078 Maybridge4_003681 FC(F)(F)c1ccc(cc1)C(=O)NCc2csc3ccc(Cl)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H08 compound treatment 2.08132028E8 4.72E7 0.59 1.31701217E8 -1.71E7 -0.29 0.2112 0.3197 3065253 Maybridge4_003682 Cc1onc(c1CNC(=O)Nc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H09 compound treatment 2.1241349E8 5.15E7 0.65 1.24371432E8 -2.45E7 -0.42 0.1605 0.2085 3179079 Maybridge4_003683 Fc1cccc(Cl)c1/C=N/Cc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H10 compound treatment 2.11706025E8 5.08E7 0.64 1.6474617E8 1.59E7 0.27 0.6429 0.9282 3065255 Maybridge4_003684 OC(=O)CC1(CC(=O)NCc2ccccn2)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H11 compound treatment 1.93567191E8 3.26E7 0.41 1.72914682E8 2.41E7 0.41 0.5809 1.0 1354093 Maybridge4_003685 CC(=O)Nc1ccccc1OCCN(Cc2ccccc2)C(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H12 compound treatment 1.88171819E8 2.72E7 0.34 1.43540105E8 -5300000.0 -0.09 0.1775 0.5021 3179080 Maybridge4_003686 CC1(C)Cc2cccc(C(=O)N3CCC(CC3)c4c[nH]c5ccccc45)c2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H13 compound treatment 2.01789696E8 4.09E7 0.51 1.82739147E8 3.39E7 0.58 0.7727 0.9981 1211536 Maybridge4_003687 COc1ccc(cc1)C(=O)CC(C(=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H14 compound treatment 2.03677752E8 4.27E7 0.54 1.63300905E8 1.45E7 0.25 0.5542 0.9384 3179081 Maybridge4_003688 FC(F)(SCc1c(Cl)cccc1Cl)C(=O)c2cnc3ccccn23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H15 compound treatment 2.03630346E8 4.27E7 0.54 1.76301331E8 2.75E7 0.47 0.7111 0.9979 3065256 Maybridge4_003689 O=C1/C(=C/C2CCCCC2)/CCCc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H16 compound treatment 1.39613111E8 -2.13E7 -0.27 1.42680932E8 -6150000.0 -0.11 -0.2637 -0.917 3179082 Maybridge4_003690 Cc1cc(nn1C)C(=O)NCc2cc(F)cc3COCOc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H17 compound treatment 1.83461252E8 2.25E7 0.28 1.56327417E8 7490000.0 0.13 0.2905 0.9361 3179083 Maybridge4_003691 CC1OCN(Cn2c1nc3ccc(Cl)cc23)c4ccc(OC(F)(F)F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H18 compound treatment 2.01793324E8 4.09E7 0.51 1.64507415E8 1.57E7 0.27 0.5521 0.9544 3065257 Maybridge4_003692 COc1ccc(CC(=O)N2CCN(CC2)c3ncccn3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H19 compound treatment 2.1946231E8 5.85E7 0.73 2.00458461E8 5.16E7 0.88 1.144 0.9958 3065258 Maybridge4_003693 COc1ccc(CNC(=S)NN)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H20 compound treatment 2.11966958E8 5.1E7 0.64 1.73778008E8 2.49E7 0.43 0.7545 0.9806 3179084 Maybridge4_003694 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3cccc4nonc34)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H21 compound treatment 1.89381011E8 2.84E7 0.36 1.76275651E8 2.74E7 0.47 0.5844 0.9908 1247395 Maybridge4_003695 CN1N=C2C(CCCc3ccccc23)C1c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H22 compound treatment 2.05813861E8 4.49E7 0.56 1.72853493E8 2.4E7 0.41 0.6888 0.9881 3065259 Maybridge4_003696 Cc1cc(c(C)s1)S(=O)(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H23 mock treatment 1.92475754E8 3.15E7 0.4 1.60811567E8 1.2E7 0.21 0.4247 0.9531 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 H24 mock treatment 1.92006033E8 3.11E7 0.39 1.74585009E8 2.57E7 0.44 0.5873 0.9981 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I01 compound treatment 2.12411892E8 5.15E7 0.65 1.93442185E8 4.46E7 0.76 0.9965 0.9965 1362748 Maybridge4_003697 CCc1cccc(C)c1NC(=S)NCCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I02 compound treatment 2.32257743E8 7.13E7 0.89 1.95722428E8 4.69E7 0.8 1.2002 0.9985 3065301 Maybridge4_003698 Clc1ccc(NC(=S)NC2CCCC2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I03 compound treatment 2.23397977E8 6.25E7 0.78 1.9996956E8 5.11E7 0.88 1.173 0.9985 1186254 Maybridge4_003699 CCN(CC)C(=O)Oc1nc(nc(COC)c1CC2CC2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I04 compound treatment 2.48054964E8 8.71E7 1.09 2.07893683E8 5.91E7 1.01 1.4876 0.9992 3065303 Maybridge4_003700 C1CN=C(Nc2ccccc2c3ccccc3)S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I05 compound treatment 2.50426629E8 8.95E7 1.12 2.16876858E8 6.8E7 1.16 1.6174 0.9998 1358941 Maybridge4_003701 Clc1ccc(cc1)c2csc(NC(=S)NC(=O)C3CC3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I06 compound treatment 2.44531151E8 8.36E7 1.05 2.30936831E8 8.21E7 1.41 1.7353 0.9896 3065304 Maybridge4_003702 CCOC(=O)c1ccc(Cl)c(NC(=S)N(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I07 compound treatment 2.47977451E8 8.7E7 1.09 2.03397171E8 5.46E7 0.93 1.4325 0.997 1536146 Maybridge4_003703 S=C(NCc1ccccc1)NC(Cc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I08 compound treatment 2.66039491E8 1.05E8 1.32 2.10946697E8 6.21E7 1.06 1.6841 0.9943 3065305 Maybridge4_003704 FC(F)(F)c1cc(NC(=S)NC2CCCCC2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I09 compound treatment 2.57367752E8 9.64E7 1.21 2.13798525E8 6.5E7 1.11 1.6417 0.9991 3179085 Maybridge4_003705 S=C1SCN(Cc2ccccc2)CN1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I10 compound treatment 2.69166711E8 1.08E8 1.36 2.09335952E8 6.05E7 1.04 1.6923 0.9911 3179086 Maybridge4_003706 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NC(=S)Nc2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I11 compound treatment 2.29342262E8 6.84E7 0.86 2.02548742E8 5.37E7 0.92 1.2569 0.9994 3065306 Maybridge4_003707 COc1ccc(CCNC(=S)NC(=O)c2ccc(Cl)cc2Cl)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I12 compound treatment 2.36308777E8 7.54E7 0.95 2.44546273E8 9.57E7 1.64 1.8271 0.9659 3179087 Maybridge4_003708 COc1ccc(/C=N/c2ccc(cc2)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I13 compound treatment 2.61533716E8 1.01E8 1.26 2.35831617E8 8.7E7 1.49 1.9453 0.9966 3065307 Maybridge4_003709 Clc1cccc(Cl)c1/N=C\2/NCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I14 compound treatment 2.32924971E8 7.2E7 0.9 2.19915814E8 7.11E7 1.22 1.4989 0.9892 1044972 Maybridge4_003710 NNC(=O)Cc1cccc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I15 compound treatment 2.56827865E8 9.59E7 1.2 2.5134698E8 1.03E8 1.75 2.0914 0.983 3065308 Maybridge4_003711 Cc1ccc2[nH]c(nc2c1)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I16 compound treatment 2.09590019E8 4.87E7 0.61 1.55710731E8 6870000.0 0.12 0.5148 0.8282 3179088 Maybridge4_003712 OC(=O)CC(CC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I17 compound treatment 1.87028391E8 2.61E7 0.33 1.41900991E8 -6930000.0 -0.12 0.1475 0.4236 3179089 Maybridge4_003713 CC(C)c1ccc2c(CCC3C(C)(CNC(=O)/C=C/C(=O)O)CCCC32C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I18 compound treatment 2.22112753E8 6.12E7 0.77 2.22541678E8 7.37E7 1.26 1.4348 0.9716 1216891 Maybridge4_003714 Ic1ccc(NC(=O)Cc2cccc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I19 compound treatment 1.14394768E8 -4.65E7 -0.58 9.5236481E7 -5.36E7 -0.92 -1.0616 -0.9762 3065310 Maybridge4_003715 Fc1ccc(NC2=NCCN2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I20 compound treatment 2.29456757E8 6.85E7 0.86 1.8386526E8 3.5E7 0.6 1.0318 0.9845 3179090 Maybridge4_003716 CC1CC(=O)N(C1=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I21 compound treatment 2.06571172E8 4.56E7 0.57 1.77559781E8 2.87E7 0.49 0.7525 0.9971 3065312 Maybridge4_003717 COc1ccc(/N=C/c2ccc(cc2)N(C)CCC#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I22 compound treatment 2.35336418E8 7.44E7 0.93 1.91165848E8 4.23E7 0.72 1.1723 0.9922 1341869 Maybridge4_003718 C1CN(CCO1)C(N2CCOCC2)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I23 mock treatment 2.37272882E8 7.63E7 0.96 2.06513584E8 5.77E7 0.99 1.3753 0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 I24 mock treatment 2.2700799E8 6.61E7 0.83 1.85447052E8 3.66E7 0.63 1.0292 0.9905 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J01 compound treatment 1.81452423E8 2.05E7 0.26 2.06106015E8 5.73E7 0.98 0.8752 0.8635 1699626 Maybridge4_003719 CC(C)(C)c1ccc(NC(=O)N2CCOCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J02 compound treatment 2.38632212E8 7.77E7 0.97 1.82478426E8 3.36E7 0.58 1.0964 0.9685 1369792 Maybridge4_003720 Fc1ccc(cc1)C2=NN(CCC2)C(=S)NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J03 compound treatment 2.36224638E8 7.53E7 0.94 1.83662999E8 3.48E7 0.6 1.0894 0.9754 3065313 Maybridge4_003721 Cc1onc(c1c2nc3ccc(I)cc3c(=O)o2)c4ccccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J04 compound treatment 2.43685501E8 8.27E7 1.04 1.80083146E8 3.12E7 0.53 1.1122 0.9525 1076697 Maybridge4_003722 CC1=NN(C(=O)C1)c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J05 compound treatment 2.9850957E7 -1.31E8 -1.64 3.1667837E7 -1.17E8 -2.01 -2.581 -0.9951 3179091 Maybridge4_003723 Cn1c(=O)sn(c2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J06 compound treatment 2.45161103E8 8.42E7 1.06 1.90524548E8 4.17E7 0.71 1.2517 0.9817 3179172 Maybridge4_003724 Clc1ccc(NC(=O)c2ccc3ncsc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J07 compound treatment 2.47878598E8 8.69E7 1.09 1.90304222E8 4.15E7 0.71 1.2731 0.9784 3065315 Maybridge4_003725 Cc1ccc(cc1)C(=O)CC(C(=O)c2ccc(cc2)C(F)(F)F)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J08 compound treatment 2.45055603E8 8.41E7 1.06 1.6584396E8 1.7E7 0.29 0.952 0.8697 3179173 Maybridge4_003726 Cc1onc(c1CNC(=O)NC2CCN(CC2)C(=O)OCc3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J09 compound treatment 2.6244448E8 1.02E8 1.27 1.8687638E8 3.8E7 0.65 1.3608 0.9515 1543567 Maybridge4_003727 CN1N=C2C(CCc3ccccc23)C1c4ccc(C#N)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J10 compound treatment 2.52411371E8 9.15E7 1.15 1.51407597E8 2570000.0 0.04 0.8425 0.7337 3065317 Maybridge4_003728 Cc1noc(c1NC(=O)Nc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J11 compound treatment 2.48895646E8 8.8E7 1.1 1.87553978E8 3.87E7 0.66 1.2489 0.9703 3179174 Maybridge4_003729 CCOC(=O)C1C(CC(=CC1=O)c2ccc3ccccc3c2)c4ccc(cc4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J12 compound treatment 2.53334432E8 9.24E7 1.16 1.82804389E8 3.4E7 0.58 1.2307 0.9491 3065318 Maybridge4_003730 CC1(C)Cc2cccc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J13 compound treatment 2.37539656E8 7.66E7 0.96 1.80402787E8 3.16E7 0.54 1.0616 0.9629 1351189 Maybridge4_003731 CC1=C(C(=O)OC(C)(C)C)C2(C(=O)Nc3ccccc32)C(=C(N)O1)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J14 compound treatment 1.84631263E8 2.37E7 0.3 1.42716886E8 -6120000.0 -0.1 0.1361 0.4319 3065319 Maybridge4_003732 CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(Cc3ccccn3)Cc4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J15 compound treatment 2.61623783E8 1.01E8 1.26 1.71887143E8 2.31E7 0.39 1.1721 0.8858 3179175 Maybridge4_003733 COc1ccc(C/N=C/c2ccc(cc2)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J16 compound treatment 2.26274963E8 6.53E7 0.82 1.41082267E8 -7750000.0 -0.13 0.4857 0.585 3065320 Maybridge4_003734 Cc1cc(nn1C)C(=O)NCc2cccn2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J17 compound treatment 2.49895441E8 8.9E7 1.12 1.88283921E8 3.94E7 0.68 1.2666 0.971 3179176 Maybridge4_003735 FC(F)(F)c1ccc(/C=C(\C#N)/c2csc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J18 compound treatment 2.41274547E8 8.03E7 1.01 1.8636531E8 3.75E7 0.64 1.1669 0.9764 3065361 Maybridge4_003736 COc1ccc(CC(=O)NCc2cc(C)oc2C(F)(F)F)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J19 compound treatment 2.25600353E8 6.47E7 0.81 1.69962986E8 2.11E7 0.36 0.8293 0.9338 3065362 Maybridge4_003737 CCOc1cccc(/C=N/c2nnc(SC)s2)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J20 compound treatment 2.41745929E8 8.08E7 1.01 1.78721468E8 2.99E7 0.51 1.0785 0.9499 3065363 Maybridge4_003738 COC(=O)c1cc(oc1C)S(=O)(=O)N2CCSC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J21 compound treatment 2.56064042E8 9.51E7 1.19 1.94775913E8 4.59E7 0.79 1.3999 0.9795 3065364 Maybridge4_003739 Cn1c2NCN(CC3CC3)Cc2c(=O)n(C)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J22 compound treatment 2.11906462E8 5.1E7 0.64 1.92485212E8 4.36E7 0.75 0.9804 0.997 3065366 Maybridge4_003740 O=C(NC1CCCCNC1=O)c2csc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J23 mock treatment 2.41003386E8 8.01E7 1.0 1.82000167E8 3.32E7 0.57 1.1116 0.9635 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 J24 mock treatment 1.90644619E8 2.97E7 0.37 1.84055006E8 3.52E7 0.6 0.6898 0.9733 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K01 compound treatment 1.50312391E8 -1.06E7 -0.13 1.26696901E8 -2.21E7 -0.38 -0.3622 -0.9017 1480507 Maybridge4_003741 Clc1ccc(Oc2ccccc2NS(=O)(=O)c3ccc(NC(=O)C4CC4)cc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K02 compound treatment 1.7280859E8 1.19E7 0.15 1.52664856E8 3830000.0 0.07 0.1516 0.9321 3065367 Maybridge4_003742 CN(C)c1ccc(/C=N/N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K03 compound treatment 1.97807141E8 3.69E7 0.46 1.70728726E8 2.19E7 0.37 0.592 0.9946 1560480 Maybridge4_003743 Cc1c(Cc2ccc(F)cc2)c(=O)oc3cc(O)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K04 compound treatment 1.68716484E8 7780000.0 0.1 1.53194937E8 4360000.0 0.07 0.1218 0.9912 3179177 Maybridge4_003744 CC(C)(C)NC(=O)Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K05 compound treatment 1.80374232E8 1.94E7 0.24 1.4848978E8 -346000.0 -0.01 0.1682 0.6897 1436913 Maybridge4_003745 COc1ccccc1NC(=S)NC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K06 compound treatment 2.01134903E8 4.02E7 0.5 1.15834553E8 -3.3E7 -0.56 -0.0429 -0.0567 1517059 Maybridge4_003746 CCOc1ccc(cc1)N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K07 compound treatment 1.92566132E8 3.16E7 0.4 1.71685354E8 2.28E7 0.39 0.5571 1.0 3179178 Maybridge4_003747 C1CCCCCC(CCCCC1)/N=C/c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K08 compound treatment 1.89021746E8 2.81E7 0.35 1.58869548E8 1.0E7 0.17 0.3706 0.9455 1293740 Maybridge4_003748 Cc1cc(C)cc(NC(=S)NC2CCCCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K09 compound treatment 1.97656028E8 3.67E7 0.46 1.65049615E8 1.62E7 0.28 0.522 0.9706 1032487 Maybridge4_003749 CCN1CSC(=S)N(CC)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K10 compound treatment 1.23329751E8 -3.76E7 -0.47 1.68717161E8 1.99E7 0.34 -0.093 -0.1598 1046043 Maybridge4_003750 NC(=N)SCCN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K11 compound treatment 2.03814208E8 4.29E7 0.54 1.5662924E8 7790000.0 0.13 0.4747 0.8565 1157754 Maybridge4_003751 COc1ccc(CCNC(=S)N(C)C)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K12 compound treatment 1.86670947E8 2.57E7 0.32 1.52432402E8 3600000.0 0.06 0.2718 0.8271 3179179 Maybridge4_003752 Cc1nc2ccccc2c(=O)n1/N=C/c3ccc(Cl)c(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K13 compound treatment 1.78948804E8 1.8E7 0.23 1.54140354E8 5300000.0 0.09 0.224 0.9198 1244335 Maybridge4_003753 S=C(NCc1cccnc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K14 compound treatment 1.71557557E8 1.06E7 0.13 1.53796036E8 4960000.0 0.08 0.1542 0.9763 3179180 Maybridge4_003754 O=C(NCCCN1CCOCC1)NCc2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K15 compound treatment 1.8676186E8 2.58E7 0.32 1.71454928E8 2.26E7 0.39 0.5028 0.9961 3065370 Maybridge4_003755 COc1cc(NC(=S)N)c(OC)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K16 compound treatment 2.19043489E8 5.81E7 0.73 1.56492973E8 7660000.0 0.13 0.6081 0.8211 3179181 Maybridge4_003756 FC(F)(F)c1cccc(NC(=O)N2CCOC32CCCCC3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K17 compound treatment 1.22070205E8 -3.89E7 -0.49 1.84355791E8 3.55E7 0.61 0.0852 0.1093 3065371 Maybridge4_003757 Cc1c(C)c(C)c(CNC(=S)NN)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K18 compound treatment 1.8553531E8 2.46E7 0.31 1.54025691E8 5190000.0 0.09 0.281 0.8751 3179182 Maybridge4_003758 O=c1oc(nc2ccccc12)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K19 compound treatment 1.84854276E8 2.39E7 0.3 1.08786127E8 -4.0E7 -0.69 -0.2726 -0.3643 3179183 Maybridge4_003759 CC/C(=N\Cc1ccc(C#N)cc1)/c2ccccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K20 compound treatment 1.93567225E8 3.26E7 0.41 1.62237286E8 1.34E7 0.23 0.4516 0.9625 1593893 Maybridge4_003760 NC(=O)C1C(C2CC1C=C2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K21 compound treatment 1.85566731E8 2.46E7 0.31 1.62243992E8 1.34E7 0.23 0.3808 0.9893 3179184 Maybridge4_003761 Fc1cccc(NC2=NCCS2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K22 compound treatment 1.54823111E8 -6120000.0 -0.08 1.65606551E8 1.68E7 0.29 0.1488 0.5006 3065373 Maybridge4_003762 Clc1ccc(cc1)C(=O)OCCc2csc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K23 mock treatment 1.2450916E8 -3.64E7 -0.46 1.73474083E8 2.46E7 0.42 -0.0249 -0.0401 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 K24 mock treatment 1.96310233E8 3.54E7 0.44 1.22024643E8 -2.68E7 -0.46 -0.0108 -0.0169 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L01 compound treatment 1.58036996E8 -2900000.0 -0.04 1.42502046E8 -6330000.0 -0.11 -0.1024 -0.8954 3179185 Maybridge4_003763 CN(C)/C=C/1\SC(=O)N(C1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L02 compound treatment 1.85213124E8 2.43E7 0.3 1.72973119E8 2.41E7 0.41 0.5075 0.9887 1281043 Maybridge4_003764 CC(C)c1ccc(NC(=S)N2CCCC(=N2)c3ccc(F)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L03 compound treatment 1.56778151E8 -4160000.0 -0.05 8.9925898E7 -5.89E7 -1.01 -0.75 -0.7427 3065374 Maybridge4_003765 O=C/1N(C(=N\C1=C\c2ccccc2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L04 compound treatment 1.50202866E8 -1.07E7 -0.13 9.6307618E7 -5.25E7 -0.9 -0.731 -0.804 3065375 Maybridge4_003766 OC(=O)c1cccnc1S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L05 compound treatment 1.41067232E8 -1.99E7 -0.25 8.237433E7 -6.65E7 -1.14 -0.9807 -0.8421 3179186 Maybridge4_003767 FC(F)(F)c1ccc(C=C2C(=O)c3ccccc3C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L06 compound treatment 1.89438856E8 2.85E7 0.36 1.00987424E8 -4.78E7 -0.82 -0.3264 -0.3652 1719441 Maybridge4_003768 Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L07 compound treatment 1.80624863E8 1.97E7 0.25 1.24212934E8 -2.46E7 -0.42 -0.1234 -0.2526 3179187 Maybridge4_003769 FC(F)(F)Oc1ccc(NC(=O)OCCc2csc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L08 compound treatment 1.80583882E8 1.96E7 0.25 1.13690235E8 -3.51E7 -0.6 -0.2511 -0.3863 3179188 Maybridge4_003770 C1COc2cc(ccc2O1)c3nc(cs3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L09 compound treatment 1.91148365E8 3.02E7 0.38 1.02774496E8 -4.61E7 -0.79 -0.2896 -0.331 3065376 Maybridge4_003771 Clc1ccc(cc1)c2nnc(c3ccccc3)c(=O)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L10 compound treatment 1.74249047E8 1.33E7 0.17 1.57019262E8 8180000.0 0.14 0.2171 0.9962 3179189 Maybridge4_003772 Cc1noc(c1NC(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L11 compound treatment 1.91233545E8 3.03E7 0.38 1.34256171E8 -1.46E7 -0.25 0.0923 0.2029 3065377 Maybridge4_003773 CN1N=C(CC1c2ccc(F)cc2)c3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L12 compound treatment 1.59494308E8 -1440000.0 -0.02 1.01466505E8 -4.74E7 -0.81 -0.5862 -0.7227 3179190 Maybridge4_003774 CC1(C)Cc2cccc(C(=O)Nc3cccc4CCCCc34)c2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L13 compound treatment 1.89864999E8 2.89E7 0.36 1.64576637E8 1.57E7 0.27 0.4471 0.9893 3065378 Maybridge4_003775 Cc1ccc2n(CNc3ccc(OC(F)(F)F)cc3)nnc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L14 compound treatment 1.58494729E8 -2440000.0 -0.03 1.51685175E8 2850000.0 0.05 0.0128 0.2224 3179191 Maybridge4_003776 O=S(=O)(N(Cc1ccccn1)Cc2ccccn2)c3ccc(s3)c4ccon4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L15 compound treatment 1.76569844E8 1.56E7 0.2 1.63881052E8 1.5E7 0.26 0.3208 0.9909 3065424 Maybridge4_003777 CCOC(=O)C1(CCC#N)C(CC(=CC1=O)c2ccc(OC)cc2)c3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L16 compound treatment 1.30265933E8 -3.07E7 -0.38 1.56552935E8 7720000.0 0.13 -0.1787 -0.4392 3065425 Maybridge4_003778 Clc1ccc(cc1)C(=O)NCc2ccc(s2)S(=O)(=O)NCCN3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L17 compound treatment 1.43864851E8 -1.71E7 -0.21 1.26794553E8 -2.2E7 -0.38 -0.4182 -0.964 3065426 Maybridge4_003779 CN(C)/C=C/C(=S)c1cccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L18 compound treatment 1.76201668E8 1.53E7 0.19 1.0956463E8 -3.93E7 -0.67 -0.34 -0.4864 3065427 Maybridge4_003780 CN1CCN(CC1)c2ccc(CNC(=O)c3cccnc3Oc4ccc(Cl)cc4)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L19 compound treatment 1.59543635E8 -1390000.0 -0.02 9.9498634E7 -4.93E7 -0.84 -0.6096 -0.7216 3065428 Maybridge4_003781 CSc1nnc(/N=C/c2c(O)ccc3ccccc23)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L20 compound treatment 2.00953412E8 4.0E7 0.5 1.70299388E8 2.15E7 0.37 0.6147 0.9882 3065429 Maybridge4_003782 OC(CSc1nc(c2ccccc2)n(n1)c3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L21 compound treatment 1.34561446E8 -2.64E7 -0.33 1.77958158E8 2.91E7 0.5 0.1185 0.1981 3065430 Maybridge4_003783 Cc1ccc(Cl)cc1NC(=S)N(N)CCO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L22 compound treatment 1.84005527E8 2.31E7 0.29 1.06394242E8 -4.24E7 -0.73 -0.3091 -0.3953 3179192 Maybridge4_003784 FC(F)(F)c1c(cnn1c2ccccc2)C(=O)NC3CCCCNC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L23 mock treatment 1.92747886E8 3.18E7 0.4 1.52425902E8 3590000.0 0.06 0.3256 0.8065 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 L24 mock treatment 1.86333171E8 2.54E7 0.32 1.59758152E8 1.09E7 0.19 0.3575 0.9677 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M01 compound treatment 1.02179702E8 -5.88E7 -0.74 9.5327567E7 -5.35E7 -0.92 -1.1689 -0.9942 3065431 Maybridge4_003785 Clc1cccc(c1)n2c(SCC3CC3)nnc2C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M02 compound treatment 1.13051203E8 -4.79E7 -0.6 1.07783797E8 -4.11E7 -0.7 -0.9217 -0.997 3179193 Maybridge4_003786 CN(C)C(=S)NC(Cc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M03 compound treatment 1.13303592E8 -4.76E7 -0.6 1.03237106E8 -4.56E7 -0.78 -0.9745 -0.9913 3179194 Maybridge4_003787 CCCc1nc(SCC(=O)c2ccccc2Cl)nc(O)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M04 compound treatment 1.26661075E8 -3.43E7 -0.43 1.24029348E8 -2.48E7 -0.42 -0.6043 -1.0 3065433 Maybridge4_003788 CCc1ccc(NC(=O)NC(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M05 compound treatment 1.34175619E8 -2.68E7 -0.34 1.23514483E8 -2.53E7 -0.43 -0.5439 -0.992 1572084 Maybridge4_003789 Cc1ccc(NC(=S)Nc2ccccc2C)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M06 compound treatment 1.37535149E8 -2.34E7 -0.29 1.27447352E8 -2.14E7 -0.37 -0.4665 -0.994 1569198 Maybridge4_003790 O=C1N(Cc2ccncc2)C(=O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M07 compound treatment 1.43496665E8 -1.74E7 -0.22 1.23222678E8 -2.56E7 -0.44 -0.4647 -0.9484 3179195 Maybridge4_003791 C(/N=C/c1ccco1)C2CCC(C/N=C/c3ccco3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M08 compound treatment 1.44417104E8 -1.65E7 -0.21 1.21376314E8 -2.75E7 -0.47 -0.4789 -0.9323 1300916 Maybridge4_003792 CCOc1ccc(NC(=S)NC(C)(C)CC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M09 compound treatment 1.30924079E8 -3.0E7 -0.38 1.0838402E8 -4.05E7 -0.69 -0.7559 -0.959 1039987 Maybridge4_003793 CC(C)N1CSC(=S)N(C1)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M10 compound treatment 1.23128273E8 -3.78E7 -0.47 1.07920035E8 -4.09E7 -0.7 -0.8306 -0.982 1339416 Maybridge4_003794 Cc1cc(ccc1Br)n2c(=O)c3ccccc3[nH]c2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M11 compound treatment 1.24477032E8 -3.65E7 -0.46 1.1021676E8 -3.86E7 -0.66 -0.7909 -0.9838 3179196 Maybridge4_003795 COc1ccc(CCN2C(=O)/C(=C/c3ccccc3Cl)/SC2=S)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M12 compound treatment 1.35560089E8 -2.54E7 -0.32 1.11137138E8 -3.77E7 -0.65 -0.6814 -0.947 3065435 Maybridge4_003796 CC(C)(C)c1ccc(cc1)C2=NC(C)(C)CO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M13 compound treatment 1.3130421E8 -2.96E7 -0.37 1.08209522E8 -4.06E7 -0.7 -0.7546 -0.9569 3179281 Maybridge4_003797 S=C(NCCc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M14 compound treatment 1.0975526E8 -5.12E7 -0.64 9.7009065E7 -5.18E7 -0.89 -1.0813 -0.9874 3179282 Maybridge4_003798 Cc1onc(c1C(=O)OC2=CC(=O)CC(C)(C)C2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M15 compound treatment 1.23088598E8 -3.78E7 -0.47 1.01813456E8 -4.7E7 -0.8 -0.9049 -0.9683 3065437 Maybridge4_003799 CC(C)c1ccc(NC(=S)NCc2ccc(C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M16 compound treatment 1.33433415E8 -2.75E7 -0.35 5.7920661E7 -9.09E7 -1.56 -1.3444 -0.8434 3179283 Maybridge4_003800 COc1ccc(cc1)C(=O)N/C(=N/c2c(C)cccc2C)/SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M17 compound treatment 1.35556614E8 -2.54E7 -0.32 1.10413577E8 -3.84E7 -0.66 -0.6902 -0.9446 3065438 Maybridge4_003801 CSc1cccc(NC(=O)N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M18 compound treatment 1.34116847E8 -2.68E7 -0.34 1.07256066E8 -4.16E7 -0.71 -0.7412 -0.9415 3065439 Maybridge4_003802 N/C(=C(\N=C\c1ccc(C#N)cc1)/C#N)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M19 compound treatment 1.45811571E8 -1.51E7 -0.19 1.32359285E8 -1.65E7 -0.28 -0.3336 -0.9814 3179284 Maybridge4_003803 O=C1CSC(=S)N1/N=C/c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M20 compound treatment 1.20156179E8 -4.08E7 -0.51 1.09313623E8 -3.95E7 -0.68 -0.8401 -0.9905 3179285 Maybridge4_003804 CCC(C)(CC(=O)O)CC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M21 compound treatment 1.28030357E8 -3.29E7 -0.41 1.08438118E8 -4.04E7 -0.69 -0.7809 -0.9696 3065440 Maybridge4_003805 Cc1ccc(cc1)C2=NN3C(C2)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M22 compound treatment 1.42659E8 -1.83E7 -0.23 1.08920113E8 -3.99E7 -0.68 -0.6453 -0.8953 1441619 Maybridge4_003806 COc1ccc(CCN2C(SC(C)C2=O)c3cccnc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M23 mock treatment 1.32255296E8 -2.87E7 -0.36 1.15644138E8 -3.32E7 -0.57 -0.6562 -0.9757 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 M24 mock treatment 1.36049483E8 -2.49E7 -0.31 1.13563524E8 -3.53E7 -0.6 -0.6477 -0.9529 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N01 compound treatment 1.36927227E8 -2.4E7 -0.3 1.12828648E8 -3.6E7 -0.62 -0.6488 -0.9458 3065441 Maybridge4_003807 S=C(N1CCSCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N02 compound treatment 1.215773E8 -3.94E7 -0.49 1.08728501E8 -4.01E7 -0.69 -0.8346 -0.9869 1195820 Maybridge4_003808 CC(C)c1ccc(cc1)C2C3CCc4ccccc4C3=NN2CCO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N03 compound treatment 1.31870407E8 -2.91E7 -0.36 1.16023384E8 -3.28E7 -0.56 -0.655 -0.9781 3065442 Maybridge4_003809 FC(F)(F)c1cc(NC(C#N)c2ccccc2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N04 compound treatment 1.34966447E8 -2.6E7 -0.33 7.3561363E7 -7.53E7 -1.29 -1.1415 -0.8589 1398220 Maybridge4_003810 OC(=O)C(C(=O)OCc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N05 compound treatment 1.27506081E8 -3.34E7 -0.42 1.14728607E8 -3.41E7 -0.58 -0.7094 -0.9868 3065443 Maybridge4_003811 CC1CC(=O)N(C1=O)c2ccc(OC(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N06 compound treatment 1.3579279E8 -2.51E7 -0.32 9.6810262E7 -5.2E7 -0.89 -0.8528 -0.9026 1541655 Maybridge4_003812 COc1ccc(NC(=O)c2ccc3ncsc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N07 compound treatment 1.29674473E8 -3.13E7 -0.39 1.16314318E8 -3.25E7 -0.56 -0.671 -0.9853 3065444 Maybridge4_003813 Oc1ccccc1/C=N/c2ccc(OC(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N08 compound treatment 1.38331412E8 -2.26E7 -0.28 7.571284E7 -7.31E7 -1.25 -1.0856 -0.8459 3179286 Maybridge4_003814 CCOC(=O)c1ccc(cc1)n2c(=S)[nH]c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N09 compound treatment 1.27648017E8 -3.33E7 -0.42 1.10561723E8 -3.83E7 -0.66 -0.7586 -0.9763 3065445 Maybridge4_003815 CC(C)c1ccc2[n+](C)cccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N10 compound treatment 9.1451182E7 -6.95E7 -0.87 1.27231252E8 -2.16E7 -0.37 -0.8779 -0.9271 3064681 Maybridge4_003816 Cc1noc(c1NC(=O)N2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N11 compound treatment 1.35237623E8 -2.57E7 -0.32 1.20220424E8 -2.86E7 -0.49 -0.5743 -0.9794 1587431 Maybridge4_003817 COc1ccc(cc1)C2CC(=NN2C)c3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N12 compound treatment 1.32916293E8 -2.8E7 -0.35 1.15907795E8 -3.29E7 -0.56 -0.6471 -0.9742 3064636 Maybridge4_003818 Fc1cc(C(=O)NCc2nc3ccccc3s2)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N13 compound treatment 1.0447315E8 -5.65E7 -0.71 5.4897068E7 -9.39E7 -1.61 -1.6379 -0.9322 3064637 Maybridge4_003819 OC(=O)/C=C/C(=O)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N14 compound treatment 1.47034257E8 -1.39E7 -0.17 8.9534862E7 -5.93E7 -1.02 -0.8411 -0.8166 3064638 Maybridge4_003820 O=C(N(Cc1ccccn1)Cc2ccccn2)c3ccc4nsnc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N15 compound treatment 1.41124323E8 -1.98E7 -0.25 1.18149487E8 -3.07E7 -0.53 -0.5472 -0.9416 1376553 Maybridge4_003821 CN1N=C2C(CCCc3ccccc23)C1c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N16 compound treatment 1.21224077E8 -3.97E7 -0.5 1.04926801E8 -4.39E7 -0.75 -0.8838 -0.9801 3064639 Maybridge4_003822 Cc1cc(CNC(=O)c2cnc3ccccc3n2)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N17 compound treatment 1.40563035E8 -2.04E7 -0.26 8.7896162E7 -6.09E7 -1.04 -0.9184 -0.8551 3064640 Maybridge4_003823 COc1ccccc1CNC(=S)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N18 compound treatment 1.25435839E8 -3.55E7 -0.45 1.06907149E8 -4.19E7 -0.72 -0.8224 -0.9737 3179287 Maybridge4_003824 CN1CCN(CC1)c2ccc(CNC(=O)c3cnn(c3C)c4ccc(Cl)cc4)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N19 compound treatment 1.42899557E8 -1.8E7 -0.23 8.4463274E7 -6.44E7 -1.1 -0.9392 -0.8349 1418353 Maybridge4_003825 CC1=NN(C(=O)C1=C2SCCCS2)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N20 compound treatment 1.49952221E8 -1.1E7 -0.14 1.31575433E8 -1.73E7 -0.3 -0.3064 -0.9397 3064641 Maybridge4_003826 OC(CSc1nccc(n1)c2ccc3OCCOc3c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N21 compound treatment 1.20757937E8 -4.02E7 -0.5 1.13493023E8 -3.53E7 -0.6 -0.7842 -0.9959 3179288 Maybridge4_003827 COc1ccc(/N=C\2/SCC(=NN2CCO)c3ccc(C)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N22 compound treatment 1.39831839E8 -2.11E7 -0.26 1.28890711E8 -1.99E7 -0.34 -0.4286 -0.9921 3179289 Maybridge4_003828 CC(C)(Oc1ccc(Cl)cc1)C(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N23 mock treatment 1.45265748E8 -1.57E7 -0.2 1.24260094E8 -2.46E7 -0.42 -0.4365 -0.94 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 N24 mock treatment 1.43798225E8 -1.71E7 -0.22 1.17938602E8 -3.09E7 -0.53 -0.526 -0.9213 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O01 compound treatment 1.15455791E8 -4.55E7 -0.57 1.02656892E8 -4.62E7 -0.79 -0.9624 -0.9872 3064642 Maybridge4_003829 Fc1ccc(NC2=NCCCC(=O)S2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O02 compound treatment 1.18185136E8 -4.28E7 -0.54 1.09033357E8 -3.98E7 -0.68 -0.861 -0.993 3179290 Maybridge4_003830 Cc1cc(/N=C/c2cc(Cl)cc(Cl)c2O)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O03 compound treatment 1.1024278E8 -5.07E7 -0.64 1.0282675E8 -4.6E7 -0.79 -1.0066 -0.9944 1155572 Maybridge4_003831 CC(C)(C)C(=O)COC(=O)Cn1nnc(n1)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O04 compound treatment 1.1859049E8 -4.23E7 -0.53 1.0606678E8 -4.28E7 -0.73 -0.8933 -0.9876 3179291 Maybridge4_003832 CC(C)(C)NC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O05 compound treatment 1.15178981E8 -4.58E7 -0.57 1.07123087E8 -4.17E7 -0.71 -0.9108 -0.9941 1006391 Maybridge4_003833 Cc1ccc(NC(=S)Nc2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O06 compound treatment 1.18038322E8 -4.29E7 -0.54 1.1500267E8 -3.38E7 -0.58 -0.7901 -0.9993 3179292 Maybridge4_003834 COc1cccc(/C=N\c2ccccc2N3C(=O)c4ccccc4C3=O)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O07 compound treatment 1.10040097E8 -5.09E7 -0.64 1.15789697E8 -3.3E7 -0.57 -0.8515 -0.9982 1631575 Maybridge4_003835 CCOc1ccc(NC(=S)NC(Cc2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O08 compound treatment 1.10177806E8 -5.08E7 -0.64 1.11163749E8 -3.77E7 -0.64 -0.9063 -1.0 3179293 Maybridge4_003836 CCOC(=O)c1ccc(NC(=S)NC(C)c2ccc3OCCOc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O09 compound treatment 1.04907908E8 -5.6E7 -0.7 9.8745865E7 -5.01E7 -0.86 -1.1033 -0.9951 1028763 Maybridge4_003837 OC(=O)CSC(=S)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O10 compound treatment 1.0573826E8 -5.52E7 -0.69 1.01636295E8 -4.72E7 -0.81 -1.061 -0.9971 3179294 Maybridge4_003838 N/C(=N\O)/c1c(cc([nH]c1=O)c2ccc(F)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O11 compound treatment 1.12872257E8 -4.81E7 -0.6 1.03507613E8 -4.53E7 -0.78 -0.975 -0.9922 1080231 Maybridge4_003839 COc1ccc(cc1)C(CC(=O)c2ccccc2)Sc3ccccc3N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O12 compound treatment 1.14301252E8 -4.66E7 -0.59 1.08271969E8 -4.06E7 -0.69 -0.9047 -0.9964 1192868 Maybridge4_003840 CC(C)c1ccc(cc1)N2C(=O)SC(C2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O13 compound treatment 1.2444774E8 -3.65E7 -0.46 1.14460872E8 -3.44E7 -0.59 -0.7398 -0.9923 3179295 Maybridge4_003841 CN(C)C(=O)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O14 compound treatment 1.04952284E8 -5.6E7 -0.7 9.771876E7 -5.11E7 -0.88 -1.1153 -0.9941 3179296 Maybridge4_003842 CC(C)(C)c1ccc(cc1)C(=O)OC2=CC(=O)CC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O15 compound treatment 1.21225255E8 -3.97E7 -0.5 1.17927725E8 -3.09E7 -0.53 -0.7264 -0.9995 3064643 Maybridge4_003843 C/C(=N\Cc1ccc(Cl)c(Cl)c1)/c2ccccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O16 compound treatment 1.21191943E8 -3.97E7 -0.5 1.16724403E8 -3.21E7 -0.55 -0.7412 -0.9988 3179297 Maybridge4_003844 CC(C)(C)NC(=S)N1CCSCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O17 compound treatment 1.24724513E8 -3.62E7 -0.45 1.16715155E8 -3.21E7 -0.55 -0.71 -0.9955 3064645 Maybridge4_003845 CSc1cccc(NC(=S)Nc2cccc(SC)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O18 compound treatment 1.15704172E8 -4.52E7 -0.57 1.09532793E8 -3.93E7 -0.67 -0.877 -0.9964 3179298 Maybridge4_003846 CN(C)/C=C/1\N=C(NC1=O)SCc2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O19 compound treatment 1.26908724E8 -3.4E7 -0.43 1.13072714E8 -3.58E7 -0.61 -0.7347 -0.9845 3179299 Maybridge4_003847 CCO/C=C/1\SC(=S)N(/N=C/c2cccc(Cl)c2)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O20 compound treatment 1.17349149E8 -4.36E7 -0.55 1.15087357E8 -3.37E7 -0.58 -0.7951 -0.9996 3064646 Maybridge4_003848 Cc1ccc(cc1)C(=O)CC(Sc2ccccc2N)c3ccsc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O21 compound treatment 1.12905347E8 -4.8E7 -0.6 1.13571697E8 -3.53E7 -0.6 -0.8529 -1.0 3179300 Maybridge4_003849 Clc1ccc(Cl)c(c1)C2=NN3C(C2)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O22 compound treatment 1.17023915E8 -4.39E7 -0.55 1.09360891E8 -3.95E7 -0.68 -0.8673 -0.9949 3064648 Maybridge4_003850 Cc1oc2ccccc2c1CCOC(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O23 mock treatment 1.22464186E8 -3.85E7 -0.48 1.06769759E8 -4.21E7 -0.72 -0.8505 -0.9811 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 O24 mock treatment 1.23666797E8 -3.73E7 -0.47 1.12279244E8 -3.66E7 -0.63 -0.7731 -0.9897 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P01 compound treatment 1.17187965E8 -4.38E7 -0.55 1.05416936E8 -4.34E7 -0.74 -0.9136 -0.9889 3179301 Maybridge4_003851 CC/1=NN(C(=O)\C1=N\O)c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P02 compound treatment 1.16074505E8 -4.49E7 -0.56 1.02304543E8 -4.65E7 -0.8 -0.9612 -0.9855 1673238 Maybridge4_003852 Fc1ccc2C3Sc4ccccc4C(=O)C3=C(c2c1)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P03 compound treatment 1.20403813E8 -4.05E7 -0.51 1.0276037E8 -4.61E7 -0.79 -0.9173 -0.9775 3179302 Maybridge4_003853 Cn1nc(sc1=S)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P04 compound treatment 1.63142507E8 2200000.0 0.03 1.74189238E8 2.54E7 0.43 0.3264 0.7506 3179303 Maybridge4_003854 Sc1nc(c(o1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P05 compound treatment 1.23235283E8 -3.77E7 -0.47 1.0969296E8 -3.91E7 -0.67 -0.8082 -0.9855 3064649 Maybridge4_003855 CC1=CC(=O)N(C1=O)c2ccc(OC(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P06 compound treatment 1.24146477E8 -3.68E7 -0.46 1.06853826E8 -4.2E7 -0.72 -0.8345 -0.9771 3179304 Maybridge4_003856 FC(F)(F)C1=NCCN(C=C1)C(=O)Nc2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P07 compound treatment 1.26504858E8 -3.44E7 -0.43 1.10300235E8 -3.85E7 -0.66 -0.7719 -0.9789 3064650 Maybridge4_003857 FC(F)(F)Oc1ccc(Nc2n[nH]c(=S)s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P08 compound treatment 1.26543888E8 -3.44E7 -0.43 1.03192211E8 -4.56E7 -0.78 -0.8576 -0.9608 3179305 Maybridge4_003858 Clc1ccc(NC(=S)N/2CCN\C2=N/c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P09 compound treatment 1.33190387E8 -2.77E7 -0.35 1.08245726E8 -4.06E7 -0.69 -0.7374 -0.9489 1422913 Maybridge4_003859 COc1ccc2cc(ccc2c1)C(C)C(=O)Nc3cc(Cl)cc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P10 compound treatment 1.11126831E8 -4.98E7 -0.62 9.9448131E7 -4.94E7 -0.85 -1.0396 -0.9889 3064682 Maybridge4_003860 OC(=O)CC1(CC(=O)Nc2cc3ccccc3cn2)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P11 compound treatment 1.2406305E8 -3.69E7 -0.46 1.10052091E8 -3.88E7 -0.66 -0.7965 -0.9844 1218065 Maybridge4_003861 Cc1ccc(cc1)n2c(SCC(=O)C(C)(C)C)nc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P12 compound treatment 1.30260757E8 -3.07E7 -0.38 1.09365598E8 -3.95E7 -0.68 -0.7499 -0.9644 3064683 Maybridge4_003862 Fc1cc(C(=O)NCc2csc(n2)c3cccs3)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P13 compound treatment 1.28210828E8 -3.27E7 -0.41 1.047812E8 -4.41E7 -0.75 -0.8236 -0.9591 3064684 Maybridge4_003863 Fc1ccc(CNC2=NCCS2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P14 compound treatment 1.44469339E8 -1.65E7 -0.21 1.2157331E8 -2.73E7 -0.47 -0.4761 -0.9328 3064685 Maybridge4_003864 O=C(N(Cc1ccccn1)Cc2ccccn2)c3ncoc3c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P15 compound treatment 1.24078405E8 -3.69E7 -0.46 1.03522618E8 -4.53E7 -0.78 -0.8754 -0.9694 3064686 Maybridge4_003865 CC(C)(C)c1ccc(cc1)c2nc(O)nn2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P16 compound treatment 1.20538336E8 -4.04E7 -0.51 1.16228916E8 -3.26E7 -0.56 -0.753 -0.9988 3179306 Maybridge4_003866 Fc1cc(CNC(=O)c2cnc3ccccc3n2)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P17 compound treatment 1.24901247E8 -3.6E7 -0.45 1.05173183E8 -4.37E7 -0.75 -0.8482 -0.971 3064687 Maybridge4_003867 COc1ccccc1Cn2nn[nH]c2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P18 compound treatment 1.26769725E8 -3.42E7 -0.43 1.05291973E8 -4.35E7 -0.75 -0.8302 -0.9655 3179307 Maybridge4_003868 CN1CCN(CC1)c2ccc(CNC(=O)c3ccc4nsnc4c3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P19 compound treatment 1.2320188E8 -3.77E7 -0.47 1.0471391E8 -4.41E7 -0.76 -0.8688 -0.9747 1399162 Maybridge4_003869 OCCN1N=C2C(CCc3ccccc23)C1c4ccccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P20 compound treatment 1.34966421E8 -2.6E7 -0.33 1.19404665E8 -2.94E7 -0.5 -0.5866 -0.9777 3179308 Maybridge4_003870 Cc1csc2c(SCC(O)C(F)(F)F)ncnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P21 compound treatment 1.32403576E8 -2.85E7 -0.36 1.1029628E8 -3.85E7 -0.66 -0.7196 -0.9587 3064689 Maybridge4_003871 NN(CCO)C(=S)NCc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P22 compound treatment 1.25155367E8 -3.58E7 -0.45 1.1734412E8 -3.15E7 -0.54 -0.6986 -0.9959 3179398 Maybridge4_003872 O=C(Cc1cccc2ccccc12)NC3CCCCNC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P23 mock treatment 1.37708662E8 -2.32E7 -0.29 1.13283093E8 -3.56E7 -0.61 -0.6364 -0.9431 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2059 P24 mock treatment 1.32894496E8 -2.8E7 -0.35 1.08856247E8 -4.0E7 -0.68 -0.7327 -0.9522 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A01 compound treatment 1.44749688E8 -1260000.0 -0.02 1.52442642E8 9930000.0 0.17 0.109 0.6387 3179399 Maybridge4_003873 Cn1nc(cc1C(=O)NC2CCCCNC2=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A02 compound treatment 1.50493257E8 4490000.0 0.06 1.56896826E8 1.44E7 0.25 0.2139 0.8469 1395167 Maybridge4_003874 CCCC1N(CCc2sccc12)C(=S)Nc3ccc(Cl)cc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A03 compound treatment 1.48250865E8 2240000.0 0.03 1.43966068E8 1450000.0 0.02 0.0375 0.9981 3179400 Maybridge4_003875 COc1cc2CCN(Cc2cc1OC)S(=O)(=O)c3ccc4OCCCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A04 compound treatment 1.66506995E8 2.05E7 0.26 1.62567036E8 2.01E7 0.34 0.4246 0.9899 1342707 Maybridge4_003876 CC(C)(C)C1=NN(C(=O)C1)c2nc3ccc(Cl)cc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A05 compound treatment 1.62163328E8 1.62E7 0.2 1.03258527E8 -3.93E7 -0.67 -0.3318 -0.4728 3179401 Maybridge4_003877 O=C(NCc1csc(n1)c2cccs2)c3ccno3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A06 compound treatment 1.68618536E8 2.26E7 0.28 1.7326305E8 3.07E7 0.53 0.5728 0.9579 1644100 Maybridge4_003878 COc1ccc(OC(=O)c2cnc3SCCn3c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A07 compound treatment 1.72856823E8 2.68E7 0.34 1.8334272E8 4.08E7 0.7 0.7324 0.944 3179402 Maybridge4_003879 O=C(NC1CCCCNC1=O)c2ccc(nc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A08 compound treatment 1.69910939E8 2.39E7 0.3 1.69981875E8 2.75E7 0.47 0.5445 0.9764 3179403 Maybridge4_003880 CC(C)(C)S(=O)(=O)/C(=C/c1sccc1C2OCCO2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A09 compound treatment 1.77111553E8 3.11E7 0.39 1.72267181E8 2.98E7 0.51 0.6361 0.9913 3064691 Maybridge4_003881 O=S(=O)(NCc1ccc(cc1)c2cccs2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A10 compound treatment 1.58981866E8 1.3E7 0.16 1.52479926E8 9970000.0 0.17 0.2357 0.9997 3179404 Maybridge4_003882 Clc1ccc(cc1)C(=O)n2cc3CSc4ccc(Cl)cc4-c3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A11 compound treatment 1.50600854E8 4590000.0 0.06 1.46176716E8 3660000.0 0.06 0.0851 0.9991 3064692 Maybridge4_003883 Cc1nn(nc1CNC(=O)CC(C)(C)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A12 compound treatment 1.39869453E8 -6140000.0 -0.08 1.45153658E8 2640000.0 0.05 -0.0225 -0.2519 3179405 Maybridge4_003884 CCOC(=O)Cn1c2CCCC(=O)c2c(cc1=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A13 compound treatment 1.36793017E8 -9210000.0 -0.12 1.39372908E8 -3140000.0 -0.05 -0.1197 -0.9394 3064694 Maybridge4_003885 Cc1noc(C)c1NC(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A14 compound treatment 1.35733548E8 -1.03E7 -0.13 1.28651919E8 -1.39E7 -0.24 -0.2589 -0.9589 3179406 Maybridge4_003886 CN(C)/C(=N/C(=S)c1ccc(Cl)cc1)/C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A15 compound treatment 1.49301629E8 3290000.0 0.04 1.4057837E8 -1940000.0 -0.03 0.0058 0.1095 3064695 Maybridge4_003887 Cc1cc(SCc2ncon2)c(Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A16 compound treatment 1.49895639E8 3890000.0 0.05 1.48940397E8 6430000.0 0.11 0.1123 0.933 3179407 Maybridge4_003888 COC(=O)c1c(C)nc(C)c(C(=O)OC)c1c2csc(c2)S(=O)(=O)/N=C/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A17 compound treatment 1.54711018E8 8700000.0 0.11 1.43518218E8 1000000.0 0.02 0.0894 0.8085 3064696 Maybridge4_003889 CSc1nc(/N=C/N(C)C)n(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A18 compound treatment 1.62602018E8 1.66E7 0.21 1.57349917E8 1.48E7 0.25 0.3268 0.9951 3179408 Maybridge4_003890 Cc1c2C(=O)/C(=C/c3ccccc3)/Cn2c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A19 compound treatment 1.53521925E8 7520000.0 0.09 1.47774663E8 5260000.0 0.09 0.1303 0.9997 3179409 Maybridge4_003891 FC(F)(F)c1ccccc1NC(=S)Nc2ccc(cc2)c3csnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A20 compound treatment 1.30875565E8 -1.51E7 -0.19 1.22820596E8 -1.97E7 -0.34 -0.3726 -0.9631 3064697 Maybridge4_003892 FC(F)(F)C1N(CCc2c1[nH]c3ccccc23)C(=O)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A21 compound treatment 1.59971299E8 1.4E7 0.18 1.52704701E8 1.02E7 0.17 0.2472 1.0 1223239 Maybridge4_003893 Clc1ccc(cc1)C2N(CCc3sccc23)C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A22 compound treatment 1.66832454E8 2.08E7 0.26 1.66596427E8 2.41E7 0.41 0.4762 0.9758 1594618 Maybridge4_003894 Cc1oc2c(F)c(F)c(F)c(F)c2c1c3noc(n3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A23 mock treatment 1.56472514E8 1.05E7 0.13 1.62697471E8 2.02E7 0.35 0.3371 0.9122 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 A24 mock treatment 1.73745468E8 2.77E7 0.35 1.60936562E8 1.84E7 0.32 0.469 0.9988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B01 compound treatment 1.23866662E8 -2.21E7 -0.28 1.33341021E8 -9170000.0 -0.16 -0.3074 -0.9635 3179410 Maybridge4_003895 O=C(/C=C/c1ccc(s1)c2cccs2)N3CCSCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B02 compound treatment 1.54641871E8 8630000.0 0.11 1.68342806E8 2.58E7 0.44 0.3892 0.8551 3064698 Maybridge4_003896 FC(F)(F)c1oc(cc1C(=O)NCc2ccco2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B03 compound treatment 1.43617669E8 -2390000.0 -0.03 1.54559694E8 1.2E7 0.21 0.1246 0.598 1349711 Maybridge4_003897 CSc1c([nH]c2ccccc12)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B04 compound treatment 1.59405261E8 1.34E7 0.17 1.52806411E8 1.03E7 0.18 0.2434 0.9997 3179411 Maybridge4_003898 Cc1nc(sc1c2ccnn2C(=O)C(C)(C)C)c3ccc(s3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B05 compound treatment 1.70737102E8 2.47E7 0.31 1.93772182E8 5.13E7 0.88 0.8398 0.9024 3064699 Maybridge4_003899 CCOC(=O)c1c(CS(=O)c2ccc(Cl)cc2)oc3c(F)c(F)c(F)c(F)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B06 compound treatment 1.76525537E8 3.05E7 0.38 1.95170334E8 5.27E7 0.9 0.9081 0.9273 3179412 Maybridge4_003900 C/C(=N\O)/C(=O)c1ccc(cc1)c2ccccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B07 compound treatment 1.63865571E8 1.79E7 0.22 1.73196371E8 3.07E7 0.53 0.5298 0.9278 3179413 Maybridge4_003901 CC1(C)COC(=N1)c2sccc2C(=O)N(C3CCCCC3)C(=O)NC4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B08 compound treatment 1.54559591E8 8550000.0 0.11 1.72040048E8 2.95E7 0.51 0.4333 0.8385 3064701 Maybridge4_003902 Nc1ccccc1SCc2cccc(Cl)c2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B09 compound treatment 1.1109712E8 -3.49E7 -0.44 1.7424313E8 3.17E7 0.54 0.0744 0.1066 1459519 Maybridge4_003903 NC(=S)c1cnc(nc1N)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B10 compound treatment 1.1089539E8 -3.51E7 -0.44 1.89861599E8 4.73E7 0.81 0.2617 0.2837 1481845 Maybridge4_003904 CCCNC(=S)N1CCC(CC1)C(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B11 compound treatment 1.58847349E8 1.28E7 0.16 1.80370656E8 3.79E7 0.65 0.5721 0.8568 3064731 Maybridge4_003905 NC(=S)c1ncc(cc1N2CCCC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B12 compound treatment 1.63097264E8 1.71E7 0.21 1.90929478E8 4.84E7 0.83 0.7376 0.8617 3064732 Maybridge4_003906 Cc1noc(C)c1c2nc(no2)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B13 compound treatment 1.53367909E8 7360000.0 0.09 1.22058496E8 -2.05E7 -0.35 -0.1823 -0.5034 3064733 Maybridge4_003907 COc1cc(NC(=O)C(C)(C)C)ccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B14 compound treatment 1.60925761E8 1.49E7 0.19 1.93199244E8 5.07E7 0.87 0.7458 0.8403 3064734 Maybridge4_003908 FC(F)(F)c1ccc(nc1)N2CCN(CC2)c3ccc(NC(=O)c4ccco4)cn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B15 compound treatment 1.63728029E8 1.77E7 0.22 1.46915193E8 4400000.0 0.08 0.2105 0.8967 3064735 Maybridge4_003909 CN(N1C(=O)c2ccccc2C1=O)c3cc(ccn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B16 compound treatment 1.57622662E8 1.16E7 0.15 1.63809944E8 2.13E7 0.36 0.3608 0.919 1391890 Maybridge4_003910 CC(C)(C)c1cc(n(n1)c2ccc(NC(=O)COCC(=O)O)cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B17 compound treatment 1.65421229E8 1.94E7 0.24 1.550779E8 1.26E7 0.22 0.3243 0.9981 3179414 Maybridge4_003911 Cc1cc(C)n(n1)c2ccc(cc2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B18 compound treatment 1.73359644E8 2.74E7 0.34 1.1757615E8 -2.49E7 -0.43 -0.0592 -0.1081 1368065 Maybridge4_003912 CC(C)Cc1ccc(cc1)C(C)c2nc(no2)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B19 compound treatment 1.52764313E8 6760000.0 0.08 9.1619018E7 -5.09E7 -0.87 -0.5561 -0.6353 1510531 Maybridge4_003913 COc1cc(cc(OC)c1OC)C(=O)NCC(c2c[nH]c3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B20 compound treatment 1.71195434E8 2.52E7 0.32 1.1406066E8 -2.85E7 -0.49 -0.121 -0.2084 1512133 Maybridge4_003914 COc1ccc(cc1)C2N(CCc3sccc23)C(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B21 compound treatment 1.83485371E8 3.75E7 0.47 1.65946543E8 2.34E7 0.4 0.6161 0.9969 3064736 Maybridge4_003915 Cc1snnc1C(=O)Oc2ccccc2c3nnco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B22 compound treatment 1.82243885E8 3.62E7 0.45 1.59319119E8 1.68E7 0.29 0.5248 0.9756 3179415 Maybridge4_003916 CC(C)(C)c1cc(n(n1)c2ccc(/N=C\c3ccccc3O)cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B23 mock treatment 1.74736564E8 2.87E7 0.36 1.28931551E8 -1.36E7 -0.23 0.0904 0.2109 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 B24 mock treatment 1.64317463E8 1.83E7 0.23 1.59699447E8 1.72E7 0.29 0.3704 0.9925 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C01 compound treatment 1.25116931E8 -2.09E7 -0.26 1.27073675E8 -1.54E7 -0.26 -0.3722 -1.0 3064737 Maybridge4_003917 Clc1ccc(Oc2ncccc2C(=O)NC3CCCCNC3=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C02 compound treatment 1.36792814E8 -9210000.0 -0.12 1.41371621E8 -1140000.0 -0.02 -0.0956 -0.8151 1245123 Maybridge4_003918 O=C(NCc1ccco1)NC(=O)c2ccc(cc2)c3csnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C03 compound treatment 1.41009406E8 -5000000.0 -0.06 1.35399709E8 -7110000.0 -0.12 -0.1304 -0.9523 3064739 Maybridge4_003919 COc1cc2CCN(Cc2cc1OC)S(=O)(=O)c3c(C)nn(C)c3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C04 compound treatment 1.4657793E8 571000.0 0.01 1.34604415E8 -7910000.0 -0.14 -0.0907 -0.6688 3179416 Maybridge4_003920 CC(C)(C)c1csc(Cc2ccc(cc2)c3csnn3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C05 compound treatment 1.40651313E8 -5360000.0 -0.07 1.30011584E8 -1.25E7 -0.21 -0.1988 -0.8864 3179417 Maybridge4_003921 Cc1oc(cc1C(=O)NCc2csc(n2)c3cccs3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C06 compound treatment 1.42857269E8 -3150000.0 -0.04 1.413261E8 -1190000.0 -0.02 -0.0423 -0.9523 1605864 Maybridge4_003922 OC(=O)CCCc1nc(no1)c2cnc3SCCn3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C07 compound treatment 1.39274127E8 -6730000.0 -0.08 1.37189314E8 -5320000.0 -0.09 -0.1242 -0.9993 3179418 Maybridge4_003923 O=C(NCC1CN(Cc2ccccc2)CCO1)c3ccc(nc3)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C08 compound treatment 1.45452079E8 -555000.0 -0.01 1.48901663E8 6390000.0 0.11 0.0724 0.6608 3064740 Maybridge4_003924 COC(=O)c1cc2CSc3ccc(Cl)cc3-c2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C09 compound treatment 1.39024803E8 -6980000.0 -0.09 1.39230332E8 -3280000.0 -0.06 -0.1017 -0.977 3179419 Maybridge4_003925 O=C(NCc1ccc(cc1)c2cccs2)C3=Cc4ccccc4OC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C10 compound treatment 1.36020564E8 -9990000.0 -0.13 1.38034755E8 -4480000.0 -0.08 -0.1428 -0.9722 3064741 Maybridge4_003926 CC(C)(C)C(=O)n1cc2CSc3ccc(Cl)cc3-c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C11 compound treatment 1.30228213E8 -1.58E7 -0.2 1.36871197E8 -5640000.0 -0.1 -0.2083 -0.9456 3179420 Maybridge4_003927 COCC(=O)NCc1nn(nc1C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C12 compound treatment 1.3881743E8 -7190000.0 -0.09 1.38564103E8 -3950000.0 -0.07 -0.1116 -0.9899 3064742 Maybridge4_003928 COC(=O)c1sccc1c2ccc(o2)c3ccn(n3)C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C13 compound treatment 1.36613728E8 -9390000.0 -0.12 1.38254227E8 -4260000.0 -0.07 -0.1349 -0.9734 3179421 Maybridge4_003929 Cc1cc(CNC(=O)Nc2c(C)noc2C)c(o1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C14 compound treatment 1.36941774E8 -9070000.0 -0.11 1.47769903E8 5260000.0 0.09 -0.0168 -0.1158 3064743 Maybridge4_003930 Clc1ccc(NC(=O)/C(=C\c2cccs2)/c3ccsc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C15 compound treatment 1.3656357E8 -9440000.0 -0.12 1.44495487E8 1980000.0 0.03 -0.0598 -0.4851 3179422 Maybridge4_003931 CN(C)C(=O)Oc1cccc(N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C16 compound treatment 1.37630232E8 -8380000.0 -0.11 1.36355773E8 -6160000.0 -0.11 -0.1488 -1.0 3179423 Maybridge4_003932 FC(F)(F)Oc1ccccc1/C=N/c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C17 compound treatment 1.27824371E8 -1.82E7 -0.23 1.32115789E8 -1.04E7 -0.18 -0.2871 -0.9925 1299325 Maybridge4_003933 CC(C)N(C(C)C)C(=O)NC(=O)c1csnn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C18 compound treatment 1.31792184E8 -1.42E7 -0.18 1.33469297E8 -9040000.0 -0.15 -0.2356 -0.9975 3179518 Maybridge4_003934 FC(F)(F)C1NCCc2c1[nH]c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C19 compound treatment 1.4185879E8 -4150000.0 -0.05 1.32974995E8 -9540000.0 -0.16 -0.1523 -0.8884 1154654 Maybridge4_003935 Cc1noc(C)c1c2nc(CSc3ccccc3)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C20 compound treatment 1.32254407E8 -1.38E7 -0.17 1.45166326E8 2650000.0 0.05 -0.0899 -0.5038 3179519 Maybridge4_003936 O=C(NCc1ccc(s1)c2cccs2)NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C21 compound treatment 1.24479453E8 -2.15E7 -0.27 1.28901639E8 -1.36E7 -0.23 -0.3557 -0.9973 1179307 Maybridge4_003937 CC(C)NC(=O)N1CCc2sccc2C1c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C22 compound treatment 1.31150698E8 -1.49E7 -0.19 1.35294499E8 -7220000.0 -0.12 -0.2192 -0.9801 3064744 Maybridge4_003938 CC(C)(C)c1nc(no1)c2ccc(s2)c3ccon3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C23 mock treatment 1.29754459E8 -1.63E7 -0.2 1.381916E8 -4320000.0 -0.07 -0.1965 -0.9059 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 C24 mock treatment 1.33855388E8 -1.22E7 -0.15 1.36866361E8 -5650000.0 -0.1 -0.1761 -0.9758 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D01 compound treatment 1.42271428E8 -3740000.0 -0.05 1.41369801E8 -1140000.0 -0.02 -0.047 -0.9251 3179520 Maybridge4_003939 CC(C)(C)c1ccc(NC(=O)/C=C/c2ccc(s2)c3cccs3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D02 compound treatment 1.36155031E8 -9850000.0 -0.12 1.38376456E8 -4140000.0 -0.07 -0.1375 -0.9651 3064745 Maybridge4_003940 COc1cccc(/C=N/c2c(c(nn2C)C(F)(F)F)c3ccccc3)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D03 compound treatment 1.41305077E8 -4700000.0 -0.06 1.58686144E8 1.62E7 0.28 0.154 0.5442 1138512 Maybridge4_003941 COc1ccc(cc1)S(=O)(=O)CC(C)(O)CS(=O)(=O)c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D04 compound treatment 1.51362454E8 5360000.0 0.07 1.52007525E8 9490000.0 0.16 0.1624 0.9236 3064746 Maybridge4_003942 FC(F)(F)c1ccc(/C=N/c2cc(Cl)cc(Cl)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D05 compound treatment 1.46282941E8 276000.0 0.0 1.46705634E8 4190000.0 0.07 0.0532 0.7404 3179521 Maybridge4_003943 Cc1noc(C)c1c2nc(COc3ccc(/C=C(/C#N)\S(=O)(=O)C)cc3)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D06 compound treatment 1.41853912E8 -4150000.0 -0.05 1.46545307E8 4030000.0 0.07 0.012 0.1383 3064747 Maybridge4_003944 CCc1sc(nc1C(=O)OC)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D07 compound treatment 1.3296682E8 -1.3E7 -0.16 1.39763387E8 -2750000.0 -0.05 -0.149 -0.8751 3064748 Maybridge4_003945 Cc1ccsc1C(=S)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D08 compound treatment 1.34676369E8 -1.13E7 -0.14 1.47586882E8 5070000.0 0.09 -0.0391 -0.2347 3179522 Maybridge4_003946 FC(F)(F)c1cc(Oc2ccc(cc2)n3cccc3)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D09 compound treatment 1.01538142E8 -4.45E7 -0.56 1.59899589E8 1.74E7 0.3 -0.184 -0.291 3064749 Maybridge4_003947 CSc1ccc(s1)C(=O)NC(=O)Nc2cc(C)on2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D10 compound treatment 1.32089744E8 -1.39E7 -0.17 1.55075144E8 1.26E7 0.22 0.0286 0.1032 3179523 Maybridge4_003948 CS/C(=N\C#N)/N1CCC(CC1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D11 compound treatment 1.38620726E8 -7390000.0 -0.09 1.42187769E8 -326000.0 -0.01 -0.0695 -0.7483 1573241 Maybridge4_003949 Cc1noc(C)c1C(=O)Oc2ccc(cc2)c3nn[nH]c3C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D12 compound treatment 1.42146129E8 -3860000.0 -0.05 1.35394138E8 -7120000.0 -0.12 -0.1204 -0.9183 3064792 Maybridge4_003950 CC(C)(C)NC(=O)N1CCN(CC1)c2ncccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D13 compound treatment 1.39659732E8 -6350000.0 -0.08 1.12534434E8 -3.0E7 -0.51 -0.4192 -0.8072 3064793 Maybridge4_003951 CCOC(=O)c1cc(CSc2ccc(Cl)cc2)c3OCOCc3c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D14 compound treatment 1.32414428E8 -1.36E7 -0.17 1.30571607E8 -1.19E7 -0.2 -0.2651 -0.9959 3064794 Maybridge4_003952 COc1ccccc1N2CCN(CC2)C(=S)c3ccccc3OC(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D15 compound treatment 1.45738286E8 -269000.0 0.0 1.45700549E8 3190000.0 0.05 0.0362 0.6622 3064795 Maybridge4_003953 CN(N1C(=O)CSCC1=O)c2cc(ccn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D16 compound treatment 1.39845342E8 -6160000.0 -0.08 1.5446946E8 1.2E7 0.2 0.0901 0.4117 3064796 Maybridge4_003954 N/C(=N\O)/c1ccc(nc1)N2CCN(CC2)c3ncccc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D17 compound treatment 1.45301557E8 -705000.0 -0.01 1.50819105E8 8310000.0 0.14 0.0943 0.6618 3064797 Maybridge4_003955 Cc1nn(c(C)c1C(=O)Oc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D18 compound treatment 1.81383259E8 3.54E7 0.44 1.61805763E8 1.93E7 0.33 0.5473 0.9894 3064798 Maybridge4_003956 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Oc2cccc3cccnc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D19 compound treatment 1.32444101E8 -1.36E7 -0.17 1.26959405E8 -1.56E7 -0.27 -0.3086 -0.9766 3064800 Maybridge4_003957 FC(F)(F)c1ccc(cc1)C(=O)NCC(c2c[nH]c3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D20 compound treatment 1.4084938E8 -5160000.0 -0.06 1.38688742E8 -3820000.0 -0.07 -0.092 -1.0 3179524 Maybridge4_003958 FC(F)(F)c1cccnc1N2CCN(CC2)c3ccc(NC(=O)Nc4ccc(Cl)cc4)cn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D21 compound treatment 1.48703711E8 2700000.0 0.03 1.41182624E8 -1330000.0 -0.02 0.0078 0.1915 3064801 Maybridge4_003959 CN(C)/C=C(\C#N)/c1nnc(c2ccccn2)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D22 compound treatment 1.5006332E8 4060000.0 0.05 1.49690731E8 7180000.0 0.12 0.1229 0.9239 3179525 Maybridge4_003960 Fc1ccc(CS(=O)(=O)CCNC(=O)c2c(F)cccc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D23 mock treatment 1.38481214E8 -7530000.0 -0.09 1.40185089E8 -2330000.0 -0.04 -0.0949 -0.9265 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 D24 mock treatment 1.36316266E8 -9690000.0 -0.12 1.35161103E8 -7350000.0 -0.13 -0.175 -0.9998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E01 compound treatment 1.20350783E8 -2.57E7 -0.32 1.20323705E8 -2.22E7 -0.38 -0.4962 -0.9966 3179526 Maybridge4_003961 O=C(NC1CCCCNC1=O)c2cn(c3ccccc23)S(=O)(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E02 compound treatment 1.28168798E8 -1.78E7 -0.22 1.27499351E8 -1.5E7 -0.26 -0.34 -0.9976 3064802 Maybridge4_003962 FC(F)(F)c1ccc(cc1)C2=NCCc3sccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E03 compound treatment 1.44909662E8 -1100000.0 -0.01 1.35358637E8 -7160000.0 -0.12 -0.0963 -0.7817 3179527 Maybridge4_003963 COc1cc2CCN(Cc2cc1OC)S(=O)(=O)c3ccc4OC(C)(C)CCc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E04 compound treatment 1.37296158E8 -8710000.0 -0.11 1.40137351E8 -2380000.0 -0.04 -0.106 -0.9094 3064804 Maybridge4_003964 O=C(Nc1ccccc1)Nc2cccc(c2)c3nnco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E05 compound treatment 1.53166489E8 7160000.0 0.09 1.32354605E8 -1.02E7 -0.17 -0.0595 -0.3038 3064805 Maybridge4_003965 CC(C)(C)OC(=O)N1CCC(CNC(=O)c2ccno2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E06 compound treatment 1.48635528E8 2630000.0 0.03 1.33608859E8 -8900000.0 -0.15 -0.0845 -0.5416 1736114 Maybridge4_003966 COc1ccc(cc1)C2N(CCc3sccc23)C(=S)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E07 compound treatment 1.39742859E8 -6260000.0 -0.08 1.31248912E8 -1.13E7 -0.19 -0.1919 -0.9217 3179528 Maybridge4_003967 Cc1nn(C)c(C)c1CNC(=O)c2ccc(nc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E08 compound treatment 1.62212584E8 1.62E7 0.2 1.37103632E8 -5410000.0 -0.09 0.0783 0.3503 3064806 Maybridge4_003968 O=C(NC(=O)c1nnc(o1)c2ccccc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E09 compound treatment 1.41994984E8 -4010000.0 -0.05 1.42448242E8 -65500.0 0.0 -0.0364 -0.7227 3179529 Maybridge4_003969 COc1ccc(cc1)n2ncc(C(=O)NCc3ccc(cc3)c4cccs4)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E10 compound treatment 1.46793813E8 787000.0 0.01 1.43083671E8 570000.0 0.01 0.0139 1.0 3064807 Maybridge4_003970 CC(C)c1ncc2CSc3ccc(Cl)cc3-c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E11 compound treatment 1.46474646E8 468000.0 0.01 1.43699657E8 1190000.0 0.02 0.0185 0.8756 3179530 Maybridge4_003971 COc1ccc(cc1)c2ocnc2C(=O)NCc3nn(nc3C)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E12 compound treatment 1.57343684E8 1.13E7 0.14 1.56992401E8 1.45E7 0.25 0.2758 0.9652 3064809 Maybridge4_003972 COC(=O)c1sccc1c2ccc(o2)c3ccn(n3)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E13 compound treatment 1.47165579E8 1160000.0 0.01 1.41658575E8 -855000.0 -0.01 -1.0E-4 -0.0036 3179531 Maybridge4_003973 Cc1c(C)c(C)c2[nH]c(nc2c1C)c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E14 compound treatment 1.51929622E8 5920000.0 0.07 1.38574233E8 -3940000.0 -0.07 0.0049 0.0484 3179532 Maybridge4_003974 FC(F)(F)c1cccc(NC(=O)/C(=C\c2cccs2)/c3ccsc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E15 compound treatment 1.52010152E8 6000000.0 0.08 1.42546401E8 32700.0 0.0 0.0536 0.7123 3064810 Maybridge4_003975 FC(F)(F)c1ccccc1N/C(=N/C#N)/N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E16 compound treatment 1.45407558E8 -599000.0 -0.01 1.33018867E8 -9490000.0 -0.16 -0.1202 -0.739 3179533 Maybridge4_003976 FC(F)(F)c1cccc(NC(=O)CS(=O)(=O)Nc2cccc(c2)C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E17 compound treatment 1.43557727E8 -2450000.0 -0.03 1.51198876E8 8690000.0 0.15 0.0834 0.5494 3064811 Maybridge4_003977 Cc1cc(NC(=O)NC(=O)c2csnn2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E18 compound treatment 1.38800842E8 -7210000.0 -0.09 1.29469887E8 -1.3E7 -0.22 -0.2218 -0.9208 3179534 Maybridge4_003978 FC(F)(F)C1N(CCc2c1[nH]c3ccccc23)C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E19 compound treatment 1.34220186E8 -1.18E7 -0.15 1.36488667E8 -6030000.0 -0.1 -0.1775 -0.9845 3064812 Maybridge4_003979 Cc1noc(C)c1c2nc(CS(=O)(=O)Cc3ccc(Cl)cc3)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E20 compound treatment 1.443257E8 -1680000.0 -0.02 9.6912412E7 -4.56E7 -0.78 -0.5669 -0.7259 3064813 Maybridge4_003980 Cc1cc(cc(C)c1I)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E21 compound treatment 1.19181101E8 -2.68E7 -0.34 1.12008295E8 -3.05E7 -0.52 -0.6072 -0.9774 1590769 Maybridge4_003981 CNC(=S)N1CCc2sccc2C1c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E22 compound treatment 1.332628958E9 1.19E9 14.89 1.550185584E9 1.41E9 24.1 27.5645 0.9732 3064814 Maybridge4_003982 CN(C)/C=N/C(=O)c1ccc(s1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E23 mock treatment 1.23720041E8 -2.23E7 -0.28 1.3707205E8 -5440000.0 -0.09 -0.2636 -0.8944 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 E24 mock treatment 1.35591866E8 -1.04E7 -0.13 1.26437476E8 -1.61E7 -0.28 -0.287 -0.942 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F01 compound treatment 1.43382197E8 -2620000.0 -0.03 1.24685727E8 -1.78E7 -0.31 -0.2391 -0.7789 3179535 Maybridge4_003983 Clc1ccc(OC(=O)/C=C/c2ccc(s2)c3cccs3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F02 compound treatment 1.14419005E8 -3.16E7 -0.4 1.28244274E8 -1.43E7 -0.24 -0.4529 -0.973 3064815 Maybridge4_003984 Cc1ccc(C)n1c2ccc(cc2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F03 compound treatment 1.36266575E8 -9740000.0 -0.12 1.1667834E8 -2.58E7 -0.44 -0.3991 -0.8699 1608279 Maybridge4_003985 CC(O)(CNCc1ccc(Cl)cc1)CSc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F04 compound treatment 1.36262537E8 -9740000.0 -0.12 1.15210937E8 -2.73E7 -0.47 -0.4169 -0.863 3179536 Maybridge4_003986 COC(=O)c1cc(=O)c2cc(NC(=O)c3ccc(OC(F)(F)F)cc3)ccc2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F05 compound treatment 1.46547015E8 540000.0 0.01 1.20939799E8 -2.16E7 -0.37 -0.2563 -0.694 3064655 Maybridge4_003987 CC1(C)COC(=N1)c2sccc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F06 compound treatment 1.42835015E8 -3170000.0 -0.04 1.36430112E8 -6080000.0 -0.1 -0.1018 -0.9129 1318553 Maybridge4_003988 NNC(=O)c1ccc(cc1)c2ccccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F07 compound treatment 1.44548412E8 -1460000.0 -0.02 1.26822255E8 -1.57E7 -0.27 -0.2029 -0.7535 3179537 Maybridge4_003989 OC1CS(=O)(=O)CC1S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F08 compound treatment 1.39221432E8 -6790000.0 -0.09 1.43642267E8 1130000.0 0.02 -0.0465 -0.5331 3064656 Maybridge4_003990 COc1cc(cc(c1C(=O)NCc2cccs2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F09 compound treatment 1.37170186E8 -8840000.0 -0.11 1.40296342E8 -2220000.0 -0.04 -0.1052 -0.898 3179538 Maybridge4_003991 CSc1ccc(s1)C(=O)NC(=O)NCc2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F10 compound treatment 1.29745683E8 -1.63E7 -0.2 1.40602937E8 -1910000.0 -0.03 -0.1674 -0.8101 1598180 Maybridge4_003992 CN(C)c1cnn(c2cnc3ccccc3n2)c(=O)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F11 compound treatment 1.32598018E8 -1.34E7 -0.17 1.30300599E8 -1.22E7 -0.21 -0.2668 -0.9942 3179539 Maybridge4_003993 Cc1nnsc1C(=O)Oc2ccc(cc2)c3nn[nH]c3C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F12 compound treatment 1.4192865E8 -4080000.0 -0.05 1.2661373E8 -1.59E7 -0.27 -0.2286 -0.8256 3179540 Maybridge4_003994 CC(C)(C)c1cc(n(n1)c2ccc(cc2)n3cccc3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F13 compound treatment 1.43665763E8 -2340000.0 -0.03 1.33205154E8 -9310000.0 -0.16 -0.1334 -0.8236 3064661 Maybridge4_003995 CCOC(=O)c1cc(CSc2ccc(cn2)C(F)(F)F)c3OCOCc3c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F14 compound treatment 1.39636234E8 -6370000.0 -0.08 1.39323933E8 -3190000.0 -0.05 -0.0951 -0.9828 1225795 Maybridge4_003996 CNC(=S)N1CCN(CC1)c2ccccc2OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F15 compound treatment 1.48039139E8 2030000.0 0.03 1.31599861E8 -1.09E7 -0.19 -0.1141 -0.605 3179541 Maybridge4_003997 Clc1cc(Cl)cc(c1)C(=O)OCCSc2cnc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F16 compound treatment 1.45113237E8 -894000.0 -0.01 1.27794065E8 -1.47E7 -0.25 -0.1861 -0.7378 3064703 Maybridge4_003998 CS(=O)(=O)Nc1ccc(nc1)N2CCN(CC2)c3ccc(cn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F17 compound treatment 1.43726179E8 -2280000.0 -0.03 9.3260401E7 -4.93E7 -0.84 -0.6164 -0.7307 3179628 Maybridge4_003999 FC(F)(F)c1cccc(NC(=S)N2CCCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F18 compound treatment 1.50653896E8 4650000.0 0.06 1.31084262E8 -1.14E7 -0.2 -0.0971 -0.4758 1219010 Maybridge4_004000 COc1cccc(Oc2ccc(OC)cc2C(=O)NN)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F19 compound treatment 1.45275543E8 -731000.0 -0.01 1.36418199E8 -6100000.0 -0.1 -0.0803 -0.7663 1054347 Maybridge4_004001 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F20 compound treatment 1.51112821E8 5110000.0 0.06 1.4554676E8 3030000.0 0.05 0.082 0.9946 1252794 Maybridge4_004002 CC(C)Cc1ccc(cc1)C(C)c2nc(no2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F21 compound treatment 1.51543549E8 5540000.0 0.07 1.33349387E8 -9160000.0 -0.16 -0.0618 -0.3603 3179629 Maybridge4_004003 Cc1nc(sc1C(=O)Nc2ccc(Cl)cc2)C(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F22 compound treatment 1.44707279E8 -1300000.0 -0.02 1.30818064E8 -1.17E7 -0.2 -0.1531 -0.7622 3179630 Maybridge4_004004 CC(C)(C)c1n[nH]c(c1Cc2c(F)cccc2Cl)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F23 mock treatment 1.46042529E8 35600.0 0.0 1.37139253E8 -5370000.0 -0.09 -0.0647 -0.7037 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 F24 mock treatment 1.33045185E8 -1.3E7 -0.16 1.28493889E8 -1.4E7 -0.24 -0.2847 -0.982 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G01 compound treatment 1.4882797E8 2820000.0 0.04 1.58245684E8 1.57E7 0.27 0.2154 0.7932 3064707 Maybridge4_004005 O=C(NC1CCCCNC1=O)c2ccc3nsnc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G02 compound treatment 1.53444808E8 7440000.0 0.09 1.55711641E8 1.32E7 0.23 0.2257 0.9235 3179631 Maybridge4_004006 Cc1noc(C)c1C(=O)N2CCc3sccc3C2c4ccc(cc4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G03 compound treatment 1.59216625E8 1.32E7 0.17 1.89588259E8 4.71E7 0.81 0.687 0.835 1266306 Maybridge4_004007 NS(=O)(=O)c1ccc(CNS(=O)(=O)c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G04 compound treatment 1.71218447E8 2.52E7 0.32 1.79390402E8 3.69E7 0.63 0.67 0.9489 3179632 Maybridge4_004008 CCOC(=O)c1ncoc1c2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G05 compound treatment 1.70865038E8 2.49E7 0.31 1.82981968E8 4.05E7 0.69 0.7103 0.935 3064708 Maybridge4_004009 Clc1cccc(NC(=O)NCc2csc(n2)c3cccs3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G06 compound treatment 1.71866439E8 2.59E7 0.32 1.79167949E8 3.67E7 0.63 0.6731 0.9529 1361028 Maybridge4_004010 COc1ccc(cc1)C2N(CCc3sccc23)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G07 compound treatment 1.72334694E8 2.63E7 0.33 1.72832812E8 3.03E7 0.52 0.6005 0.9762 3179633 Maybridge4_004011 O=C(N1CCC2(CC1)NC(=O)c3ccccc3O2)c4ncoc4c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G08 compound treatment 1.44774241E8 -1230000.0 -0.02 1.36597679E8 -5920000.0 -0.1 -0.0825 -0.8057 3064709 Maybridge4_004012 NC(=S)c1sccc1CS(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G09 compound treatment 1.74067323E8 2.81E7 0.35 1.75045212E8 3.25E7 0.56 0.6427 0.9755 3179634 Maybridge4_004013 COc1ccccc1CC(=O)NCc2ccc(cc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G10 compound treatment 1.68767258E8 2.28E7 0.29 1.74413965E8 3.19E7 0.55 0.588 0.9543 3064710 Maybridge4_004014 FC(F)(F)c1cc(=O)[nH]c2CCCC(=O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G11 compound treatment 1.60993187E8 1.5E7 0.19 1.73716409E8 3.12E7 0.53 0.5106 0.9018 3179635 Maybridge4_004015 Cc1nn(nc1CNC(=O)C2CC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G12 compound treatment 1.68582542E8 2.26E7 0.28 1.66704163E8 2.42E7 0.41 0.4931 0.9828 3064711 Maybridge4_004016 FC(F)(F)c1cccc(OCc2ccc(cc2)c3ncns3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G13 compound treatment 1.5741127E8 1.14E7 0.14 1.61589493E8 1.91E7 0.33 0.3321 0.9314 3179636 Maybridge4_004017 Fc1cc(C(=O)NCc2ccco2)c3OCOCc3c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G14 compound treatment 1.70167839E8 2.42E7 0.3 1.55952762E8 1.34E7 0.23 0.377 0.9907 3064712 Maybridge4_004018 Fc1ccc(OC(=O)/C(=C\c2cccs2)/c3ccsc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G15 compound treatment 1.63168499E8 1.72E7 0.22 1.54430111E8 1.19E7 0.2 0.2965 0.9996 3179637 Maybridge4_004019 COC(=O)C1=NN(C(=O)C1)c2c(C)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G16 compound treatment 1.64796948E8 1.88E7 0.24 1.52402455E8 9890000.0 0.17 0.2864 0.9868 1285053 Maybridge4_004020 Fc1ccc(NC(=O)CS(=O)(=O)Nc2ccc(F)cc2Cl)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G17 compound treatment 1.57768822E8 1.18E7 0.15 1.60899328E8 1.84E7 0.31 0.3269 0.9404 3179638 Maybridge4_004021 Clc1ccc(CSCc2ccc(cc2)c3csnn3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G18 compound treatment 1.5560549E8 9600000.0 0.12 1.49048518E8 6530000.0 0.11 0.1642 0.9993 1173952 Maybridge4_004022 COc1cc(NS(=O)(=O)c2c(C)oc3c(F)c(F)c(F)c(F)c23)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G19 compound treatment 1.65216349E8 1.92E7 0.24 1.51966535E8 9450000.0 0.16 0.2848 0.9812 1587917 Maybridge4_004023 Clc1cc(Cl)cc(c1)C(=O)NCc2ccc(cc2)c3csnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G20 compound treatment 1.61443186E8 1.54E7 0.19 1.64858206E8 2.23E7 0.38 0.4074 0.9503 3179639 Maybridge4_004024 Clc1ccc(/C=N/Cc2ccc(s2)c3cccs3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G21 compound treatment 1.58539079E8 1.25E7 0.16 1.53647951E8 1.11E7 0.19 0.2459 0.9954 3064752 Maybridge4_004025 Cc1cc(C(=O)O)c(C)n1c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G22 compound treatment 1.72209596E8 2.62E7 0.33 1.66654754E8 2.41E7 0.41 0.5246 0.9936 1446641 Maybridge4_004026 COc1ccc2ncc3COc4ccc(Cl)cc4-c3c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G23 mock treatment 1.61655743E8 1.56E7 0.2 1.57246932E8 1.47E7 0.25 0.3171 0.9923 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 G24 mock treatment 1.57550162E8 1.15E7 0.14 1.69627042E8 2.71E7 0.46 0.4306 0.8856 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H01 compound treatment 1.72816152E8 2.68E7 0.34 1.50149919E8 7640000.0 0.13 0.3302 0.9152 3064753 Maybridge4_004027 CC(=O)Nc1ccccc1OCC(O)CS(=O)(=O)c2ccc(cn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H02 compound treatment 1.54660616E8 8650000.0 0.11 1.41160059E8 -1350000.0 -0.02 0.0604 0.5439 3064754 Maybridge4_004028 CC(C)c1ccc(C)c2c(C#N)cc(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H03 compound treatment 1.75521866E8 2.95E7 0.37 1.60446951E8 1.79E7 0.31 0.4789 0.9957 3064755 Maybridge4_004029 Cc1noc(c1c2nnc(o2)c3cccc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H04 compound treatment 1.74672212E8 2.87E7 0.36 1.66273529E8 2.38E7 0.41 0.5419 0.9981 3064756 Maybridge4_004030 COc1ccc(C/N=C/c2ccc(OC)c(OC)c2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H05 compound treatment 1.8452595E8 3.85E7 0.48 1.74307524E8 3.18E7 0.54 0.7265 0.9982 3064758 Maybridge4_004031 Clc1ccc(cc1)c2cc[nH]n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H06 compound treatment 1.88753791E8 4.27E7 0.54 1.6243279E8 1.99E7 0.34 0.6203 0.9761 3179640 Maybridge4_004032 COC(=O)Cc1nc(sc1C)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H07 compound treatment 1.9839453E8 5.24E7 0.66 1.67251091E8 2.47E7 0.42 0.7641 0.9774 1266051 Maybridge4_004033 COc1ccc(cc1)S(=O)(=O)C2CS(=O)(=O)CC2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H08 compound treatment 1.68858952E8 2.29E7 0.29 1.50549351E8 8040000.0 0.14 0.3 0.9434 3179641 Maybridge4_004034 COc1cc(cc(c1C(=O)N2CCC(CC2)C(=O)c3ccc(Cl)cc3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H09 compound treatment 1.73860981E8 2.79E7 0.35 1.72914094E8 3.04E7 0.52 0.615 0.9812 1103147 Maybridge4_004035 N#Cc1c(nc2SCCn12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H10 compound treatment 1.80384711E8 3.44E7 0.43 1.64187414E8 2.17E7 0.37 0.5673 0.9972 3179642 Maybridge4_004036 Brc1cc(Br)cc(c1)C(=O)NC(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H11 compound treatment 1.64376456E8 1.84E7 0.23 1.56412064E8 1.39E7 0.24 0.3312 0.9999 3064759 Maybridge4_004037 O=S(=O)(/C(=C/c1ccc(s1)C2=CCOc3ccccc23)/C#N)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H12 compound treatment 1.69158265E8 2.32E7 0.29 1.70909317E8 2.84E7 0.49 0.5491 0.9697 1625813 Maybridge4_004038 CCN(CC)c1ccc(NC(=O)c2ccc(Cl)cc2)c(n1)N(CC)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H13 compound treatment 1.74162438E8 2.82E7 0.35 1.67302629E8 2.48E7 0.42 0.5498 0.9958 3179643 Maybridge4_004039 CCOC(=O)c1cc(CSc2cccc(c2)C(F)(F)F)c3OCOCc3c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H14 compound treatment 1.72283579E8 2.63E7 0.33 1.48562892E8 6050000.0 0.1 0.3063 0.8865 3064760 Maybridge4_004040 Cc1ccc(SCCC(=O)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H15 compound treatment 1.91154971E8 4.51E7 0.57 1.68766278E8 2.63E7 0.45 0.7182 0.9934 1714044 Maybridge4_004041 O=C1CC(Sc2ccccc2N1)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H16 compound treatment 1.62156446E8 1.61E7 0.2 1.62781998E8 2.03E7 0.35 0.3886 0.9672 3179644 Maybridge4_004042 CNC(=S)Nc1ccc(nc1)N2CCN(CC2)c3ccc(cn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H17 compound treatment 1.92987294E8 4.7E7 0.59 1.65865465E8 2.34E7 0.4 0.6994 0.9821 3064761 Maybridge4_004043 FC(F)(F)c1ccccc1NC(=S)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H18 compound treatment 1.77896542E8 3.19E7 0.4 1.52237279E8 9720000.0 0.17 0.4006 0.9245 3179645 Maybridge4_004044 Cc1ccc(SCc2cccc(c2)C(=O)N3CCN(CC3)c4ncccc4C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H19 compound treatment 1.80543733E8 3.45E7 0.43 1.73373283E8 3.09E7 0.53 0.6799 0.9952 3064762 Maybridge4_004045 FC(F)(F)C(CNC(=O)Nc1ccccc1)c2ccc[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H20 compound treatment 1.87793883E8 4.18E7 0.52 1.65285872E8 2.28E7 0.39 0.6463 0.9894 3179646 Maybridge4_004046 FC(F)(F)Oc1ccc(cc1)C2N(CCc3sccc23)C(=O)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H21 compound treatment 1.79454939E8 3.34E7 0.42 1.58497186E8 1.6E7 0.27 0.4902 0.9785 1471144 Maybridge4_004047 Cc1nc(sc1C(=O)Oc2ccc(Cl)cc2)C(=O)Oc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H22 compound treatment 1.74044528E8 2.8E7 0.35 1.47868976E8 5360000.0 0.09 0.3135 0.8626 3179647 Maybridge4_004048 CC(C)(C)C(=O)C(Cc1c(F)cccc1Cl)C(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H23 mock treatment 1.75280347E8 2.93E7 0.37 1.61499311E8 1.9E7 0.32 0.4895 0.9981 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 H24 mock treatment 1.57549973E8 1.15E7 0.14 1.58199016E8 1.57E7 0.27 0.2922 0.958 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I01 compound treatment 1.65357419E8 1.94E7 0.24 1.70871409E8 2.84E7 0.49 0.5149 0.9487 3064764 Maybridge4_004049 Cc1nn(C)c2sc(cc12)C(=O)NC3CCCCNC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I02 compound treatment 1.73739414E8 2.77E7 0.35 1.7993992E8 3.74E7 0.64 0.699 0.9588 3179648 Maybridge4_004050 FC(F)(F)c1ccc(cc1)C2N(CCc3sccc23)C(=O)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I03 compound treatment 1.74364496E8 2.84E7 0.36 1.86989184E8 4.45E7 0.76 0.7899 0.94 3179649 Maybridge4_004051 CC1(C)CCc2cc(ccc2O1)S(=O)(=O)NCc3ccc(cc3)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I04 compound treatment 1.90563239E8 4.46E7 0.56 1.89521499E8 4.7E7 0.8 0.9642 0.9841 3064766 Maybridge4_004052 NNC(=O)c1ncoc1c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I05 compound treatment 2.01194579E8 5.52E7 0.69 1.8509246E8 4.26E7 0.73 1.0049 0.9997 3064767 Maybridge4_004053 Cc1cc(C)cc(NC(=O)NCc2csc(n2)c3cccs3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I06 compound treatment 1.82200776E8 3.62E7 0.45 1.9103401E8 4.85E7 0.83 0.9084 0.9596 1598083 Maybridge4_004054 NNC(=O)CS(=O)(=O)Cc1ccc(cc1)c2csnn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I07 compound treatment 1.8226423E8 3.63E7 0.45 1.9814129E8 5.56E7 0.95 0.9949 0.9428 3179650 Maybridge4_004055 O=C(NCc1ccc2OCCc2c1)c3ccc4nsnc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I08 compound treatment 2.07408366E8 6.14E7 0.77 2.50857646E8 1.08E8 1.85 1.8561 0.9242 1651781 Maybridge4_004056 CC(C)(C)c1csc(n1)c2sccc2COc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I09 compound treatment 1.79022621E8 3.3E7 0.41 1.8356818E8 4.11E7 0.7 0.7898 0.9682 3179651 Maybridge4_004057 Cn1nc(cc1C(=O)NCc2ccc(cc2)c3cccs3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I10 compound treatment 1.68605596E8 2.26E7 0.28 1.46737293E8 4220000.0 0.07 0.2516 0.8599 1154669 Maybridge4_004058 Cc1nn(cc1c2nsc(Nc3ccccc3)n2)C(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I11 compound treatment 1.92312878E8 4.63E7 0.58 2.00350009E8 5.78E7 0.99 1.1108 0.9677 3179736 Maybridge4_004059 CN1CCOc2cc(ccc12)S(=O)(=O)NCc3nn(nc3C)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I12 compound treatment 1.99062656E8 5.31E7 0.67 1.97337605E8 5.48E7 0.94 1.1342 0.9858 3064768 Maybridge4_004060 Fc1ccc(NC(=O)NC(=O)c2csc(n2)c3ccc(cc3Cl)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I13 compound treatment 1.8276839E8 3.68E7 0.46 1.77260151E8 3.47E7 0.59 0.7467 0.9921 3179737 Maybridge4_004061 Fc1cc(C(=O)NCc2ccc(cc2)N3CCOCC3)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I14 compound treatment 2.0123454E8 5.52E7 0.69 2.02427666E8 5.99E7 1.03 1.2151 0.9818 3179738 Maybridge4_004062 Cc1cc(NC(=O)/C(=C/c2cccs2)/c3ccsc3)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I15 compound treatment 1.59332091E8 1.33E7 0.17 1.88526441E8 4.6E7 0.79 0.6751 0.8385 3064816 Maybridge4_004063 COC(=O)C/1=NN(C(=O)\C1=N/O)c2c(C)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I16 compound treatment 1.82425949E8 3.64E7 0.46 1.74846011E8 3.23E7 0.55 0.7144 0.9955 3064817 Maybridge4_004064 COC(=O)C/1=NN(C(=O)\C1=C/N(C)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I17 compound treatment 1.96518385E8 5.05E7 0.63 1.8500085E8 4.25E7 0.73 0.9623 0.9976 3064818 Maybridge4_004065 FC(F)(F)c1cc(/C=C(\C#N)/S(=O)(=O)c2ccccc2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I18 compound treatment 2.00262957E8 5.43E7 0.68 1.96770506E8 5.43E7 0.93 1.138 0.9883 3064819 Maybridge4_004066 OC(=O)c1coc2CCC/C(=N\N3CCCCC3)/c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I19 compound treatment 1.76355933E8 3.03E7 0.38 1.97147209E8 5.46E7 0.94 0.9305 0.9215 1604639 Maybridge4_004067 CNC(=S)NCc1ccc(cc1)c2csnn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I20 compound treatment 1.94801498E8 4.88E7 0.61 2.14411694E8 7.19E7 1.23 1.3031 0.948 3064820 Maybridge4_004068 FC(F)(F)c1cccc(/C=N/Cc2ccc(s2)c3cccs3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I21 compound treatment 1.94281951E8 4.83E7 0.61 1.98082324E8 5.56E7 0.95 1.1008 0.9762 3064821 Maybridge4_004069 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Oc2ccc(cc2)c3csnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I22 compound treatment 1.68005313E8 2.2E7 0.28 1.8561495E8 4.31E7 0.74 0.7168 0.91 3064822 Maybridge4_004070 COc1cc(/C=C\2/N=C(C)OC2=O)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I23 mock treatment 1.86622816E8 4.06E7 0.51 1.95601451E8 5.31E7 0.91 1.0029 0.9626 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 I24 mock treatment 1.71262713E8 2.53E7 0.32 1.75872816E8 3.34E7 0.57 0.6278 0.9614 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J01 compound treatment 1.86525248E8 4.05E7 0.51 1.68217226E8 2.57E7 0.44 0.6705 0.9974 3064823 Maybridge4_004071 CSc1cc(n[nH]1)c2nccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J02 compound treatment 1.79274918E8 3.33E7 0.42 1.37654773E8 -4860000.0 -0.08 0.2363 0.5553 3179739 Maybridge4_004072 CC(C)c1ccc(C)c2c(/C=C(/C#N)\S(=O)(=O)C)cc(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J03 compound treatment 1.66689547E8 2.07E7 0.26 1.50783579E8 8270000.0 0.14 0.2836 0.9594 3064824 Maybridge4_004073 Nc1nc2c(c(sc2s1)C(F)(F)F)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J04 compound treatment 1.36527751E8 -9480000.0 -0.12 1.58843001E8 1.63E7 0.28 0.1136 0.3739 3179740 Maybridge4_004074 NC(=S)Nc1ccc(cc1Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J05 compound treatment 1.74406532E8 2.84E7 0.36 1.78348106E8 3.58E7 0.61 0.6857 0.9666 3179741 Maybridge4_004075 COC(=O)c1sc(c(c1S(=O)(=O)N2CCOCC2)c3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J06 compound treatment 1.62359734E8 1.64E7 0.21 1.74165604E8 3.17E7 0.54 0.5282 0.9117 3064825 Maybridge4_004076 CC(C)N(C(C)C)C(=O)c1ccc(cc1)c2ccccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J07 compound treatment 1.46060216E8 53300.0 0.0 1.94683517E8 5.22E7 0.89 0.6319 0.7076 1125107 Maybridge4_004077 Clc1snnc1CN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J08 compound treatment 1.92782562E8 4.68E7 0.59 2.11174496E8 6.87E7 1.18 1.246 0.9485 3179742 Maybridge4_004078 Clc1ccc(Sc2ccc(C#N)cn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J09 compound treatment 1.71203363E8 2.52E7 0.32 1.83783061E8 4.13E7 0.71 0.723 0.9342 3179743 Maybridge4_004079 COc1cc(cc(OC)c1OC)C(=O)OC(Cc2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J10 compound treatment 1.58003108E8 1.2E7 0.15 1.13278131E8 -2.92E7 -0.5 -0.2475 -0.4735 1420510 Maybridge4_004080 NC(=S)c1nc(oc1N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J11 compound treatment 2.09668365E8 6.37E7 0.8 1.9733355E8 5.48E7 0.94 1.2282 0.9968 3064826 Maybridge4_004081 CCOC(=O)Cc1csc(n1)c2ncc(cc2Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J12 compound treatment 1.96041809E8 5.0E7 0.63 2.00968045E8 5.85E7 1.0 1.1514 0.9748 1571322 Maybridge4_004082 CCN(CC)c1ccc(NC(=O)C2CCCCC2)c(n1)N(CC)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J13 compound treatment 1.88958135E8 4.3E7 0.54 1.93099661E8 5.06E7 0.87 0.9933 0.9739 3064827 Maybridge4_004083 CC(C)(C)Cc1nc(no1)C2(CC2)c3ccc(Cl)cc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J14 compound treatment 1.7350975E8 2.75E7 0.35 1.64256872E8 2.17E7 0.37 0.5071 0.9993 3179744 Maybridge4_004084 CN(C)c1ccc(/C=C(\C#N)/S(=O)(=O)c2ccccc2)cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J15 compound treatment 1.85282613E8 3.93E7 0.49 1.8910629E8 4.66E7 0.8 0.9124 0.9732 1672501 Maybridge4_004085 O=C(NC(=O)N1CCCC1)C2CCN(CC2)c3cnc4ccccc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J16 compound treatment 1.96311838E8 5.03E7 0.63 1.99006593E8 5.65E7 0.97 1.13 0.9786 3064828 Maybridge4_004086 CC(C)Cc1ccc(cc1)C(C)C(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J17 compound treatment 1.86142984E8 4.01E7 0.5 1.98792154E8 5.63E7 0.96 1.0372 0.9542 1716306 Maybridge4_004087 O=C(C1CCN(CC1)C(=O)c2ccco2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J18 compound treatment 1.93480677E8 4.75E7 0.6 2.00355659E8 5.78E7 0.99 1.1212 0.9704 1727489 Maybridge4_004088 Cc1ccc(F)cc1N2CC(CC2=O)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J19 compound treatment 1.76253533E8 3.02E7 0.38 2.01034207E8 5.85E7 1.0 0.9766 0.9117 3179745 Maybridge4_004089 Clc1ccc(/C=C/2\COC/C(=C\c3ccc(Cl)cc3)/C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J20 compound treatment 1.8826214E8 4.23E7 0.53 1.72082967E8 2.96E7 0.51 0.7327 0.9997 1700558 Maybridge4_004090 CC(C)(C)c1ccc(cc1)C(=O)N2CCC(CC2)c3nc(no3)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J21 compound treatment 1.82689716E8 3.67E7 0.46 1.77368708E8 3.49E7 0.6 0.7473 0.9918 3064829 Maybridge4_004091 Fc1ccc(NC(=O)Cc2cc(F)cc(F)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J22 compound treatment 1.57664984E8 1.17E7 0.15 1.8875207E8 4.62E7 0.79 0.6631 0.8238 3064830 Maybridge4_004092 CC(C)(C)c1nnc(o1)c2cccc(NS(=O)(=O)c3ccc(s3)c4ccon4)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J23 mock treatment 1.87473296E8 4.15E7 0.52 1.79488246E8 3.7E7 0.63 0.8154 0.9953 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 J24 mock treatment 1.66511108E8 2.05E7 0.26 1.83289424E8 4.08E7 0.7 0.6754 0.908 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K01 compound treatment 1.43046765E8 -2960000.0 -0.04 1.29375569E8 -1.31E7 -0.22 -0.1853 -0.8129 3179746 Maybridge4_004093 Clc1ccc(cc1)S(=O)(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K02 compound treatment 1.49458568E8 3450000.0 0.04 1.39758807E8 -2750000.0 -0.05 -0.0027 -0.0426 3179747 Maybridge4_004094 FC(F)(F)c1ccc(cc1)C(=O)Nc2cccc(c2)c3nnco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K03 compound treatment 1.45113803E8 -893000.0 -0.01 1.36339481E8 -6170000.0 -0.11 -0.0827 -0.7777 3064831 Maybridge4_004095 O=S(=O)(NCC1COc2ccccc2O1)c3ccc(nc3)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K04 compound treatment 1.43030487E8 -2980000.0 -0.04 1.43946769E8 1430000.0 0.02 -0.0091 -0.2027 1348923 Maybridge4_004096 Cc1cc(NC(=O)CCOc2ccc(F)cc2)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K05 compound treatment 1.50229388E8 4220000.0 0.05 1.33996863E8 -8520000.0 -0.15 -0.0656 -0.4231 3179748 Maybridge4_004097 Cc1cc(c(C)o1)S(=O)(=O)NCC2CCN(CC2)C(=O)OC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K06 compound treatment 1.65860042E8 1.99E7 0.25 1.6155768E8 1.9E7 0.33 0.4066 0.9912 1281685 Maybridge4_004098 NC(=O)c1cnc2SCCn2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K07 compound treatment 1.62578278E8 1.66E7 0.21 1.69453809E8 2.69E7 0.46 0.4731 0.9352 3064832 Maybridge4_004099 COc1ccc(cc1)C(=O)NCc2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K08 compound treatment 1.67128052E8 2.11E7 0.26 1.66048125E8 2.35E7 0.4 0.4722 0.9793 3179749 Maybridge4_004100 CC(C)(C)c1csc(n1)c2sccc2CS(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K09 compound treatment 1.68268027E8 2.23E7 0.28 1.61403272E8 1.89E7 0.32 0.4261 0.9973 3179750 Maybridge4_004101 COc1ccccc1CC(=O)NCc2nn(nc2C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K10 compound treatment 1.9018644E8 4.42E7 0.55 1.71846721E8 2.93E7 0.5 0.7469 0.9988 3064834 Maybridge4_004102 FC(F)(F)c1ccc(SCCS(=O)(=O)CCSc2ccc(cn2)C(F)(F)F)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K11 compound treatment 1.73151632E8 2.71E7 0.34 1.68050628E8 2.55E7 0.44 0.5499 0.9924 3179751 Maybridge4_004103 Cc1noc(C)c1S(=O)(=O)NCc2nn(nc2C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K12 compound treatment 1.64671119E8 1.87E7 0.23 1.57373053E8 1.49E7 0.25 0.3454 0.9991 3064714 Maybridge4_004104 OC(=O)c1ncoc1c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K13 compound treatment 1.6497661E8 1.9E7 0.24 1.40222141E8 -2290000.0 -0.04 0.1405 0.5827 1121050 Maybridge4_004105 CCOC(=O)c1c(NC(=O)C)nc(SC)n1Cc2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K14 compound treatment 1.64739437E8 1.87E7 0.23 1.59805081E8 1.73E7 0.3 0.3755 0.9935 3179752 Maybridge4_004106 FC(F)(F)c1ccc(SC(=O)/C(=C\c2cccs2)/c3ccsc3)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K15 compound treatment 1.72082652E8 2.61E7 0.33 1.63471163E8 2.1E7 0.36 0.485 0.9989 3064716 Maybridge4_004107 CCOC(=O)c1n[nH]c(=S)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K16 compound treatment 1.7438805E8 2.84E7 0.36 1.74692928E8 3.22E7 0.55 0.6413 0.9777 3179753 Maybridge4_004108 COC(=O)c1nn(c2ccccc2)c3oc(=O)cc(C)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K17 compound treatment 1.54654836E8 8650000.0 0.11 1.57064886E8 1.46E7 0.25 0.2528 0.9306 3064717 Maybridge4_004109 CC(C)(C)S(=O)(=O)/C(=C/c1cc(cc(c1)C(F)(F)F)C(F)(F)F)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K18 compound treatment 1.6410751E8 1.81E7 0.23 1.5302943E8 1.05E7 0.18 0.2878 0.9934 3179754 Maybridge4_004110 FC(F)(F)C1N(CCc2c1[nH]c3ccccc23)C(=O)c4cccc(c4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K19 compound treatment 1.48810415E8 2800000.0 0.04 1.56879746E8 1.44E7 0.25 0.1988 0.8001 3064769 Maybridge4_004111 CC1=NN(C(=O)C1)c2ccc(cc2)c3csnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K20 compound treatment 1.93569877E8 4.76E7 0.6 1.87921585E8 4.54E7 0.78 0.9715 0.9915 1351476 Maybridge4_004112 Fc1ccccc1NC(=O)NCc2sccc2COc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K21 compound treatment 1.62309585E8 1.63E7 0.2 1.76016965E8 3.35E7 0.57 0.5501 0.9035 3064771 Maybridge4_004113 CCCC1N(CCc2sccc12)C(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K22 compound treatment 1.58445119E8 1.24E7 0.16 1.75691158E8 3.32E7 0.57 0.5119 0.8692 3179755 Maybridge4_004114 COc1cc(/C=C(\NC(=O)C)/C(=O)O)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K23 mock treatment 1.5938747E8 1.34E7 0.17 1.8189112E8 3.94E7 0.67 0.5953 0.857 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 K24 mock treatment 1.75284602E8 2.93E7 0.37 1.43458989E8 945000.0 0.02 0.2711 0.7375 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L01 compound treatment 9.630465E7 -4.97E7 -0.62 1.05603674E8 -3.69E7 -0.63 -0.8876 -1.0 3064772 Maybridge4_004115 FC(F)(F)c1sc(cc1c2ccccc2)C(=O)Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L02 compound treatment 2.41251779E8 9.52E7 1.19 2.09718186E8 6.72E7 1.15 1.6583 0.9998 3179756 Maybridge4_004116 NC(=S)c1ccc(s1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L03 compound treatment 1.08943595E8 -3.71E7 -0.46 1.19663049E8 -2.29E7 -0.39 -0.6054 -0.9963 3179757 Maybridge4_004117 COc1ccc(SCc2nsc(Sc3ccc(OC)cc3)n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L04 compound treatment 1.53858819E8 7850000.0 0.1 1.02347695E8 -4.02E7 -0.69 -0.4165 -0.5997 3064773 Maybridge4_004118 OC(=O)c1c-2c(CSc3ccc(Cl)cc32)nc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L05 compound treatment 2.13076673E8 6.71E7 0.84 2.22200294E8 7.97E7 1.36 1.5595 0.973 3179758 Maybridge4_004119 CSC(=N)Nc1csc(c1c2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L06 compound treatment 1.39692568E8 -6310000.0 -0.08 1.51344134E8 8830000.0 0.15 0.0509 0.2981 3179759 Maybridge4_004120 O=C/1Nc2ccccc2\C1=C/c3ccccc3N4CCN(Cc5ccccc5)CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L07 compound treatment 1.26397127E8 -1.96E7 -0.25 1.37628994E8 -4880000.0 -0.08 -0.2331 -0.8971 3064774 Maybridge4_004121 NC(=S)c1cc(c(s1)C(F)(F)F)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L08 compound treatment 1.15816356E8 -3.02E7 -0.38 1.66398729E8 2.39E7 0.41 0.0213 0.0382 3064775 Maybridge4_004122 CCOC(=O)Cc1c(C#N)c(N)sc1C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L09 compound treatment 1.48866166E8 2860000.0 0.04 1.44943685E8 2430000.0 0.04 0.0548 0.9973 3179760 Maybridge4_004123 FC(F)(F)C(Cc1ccccc1)OC(=O)c2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L10 compound treatment 1.46563405E8 556000.0 0.01 1.55892818E8 1.34E7 0.23 0.1669 0.7283 3064776 Maybridge4_004124 CC(C)(C)c1ccc(s1)C(=O)Nc2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L11 compound treatment 1.44453068E8 -1550000.0 -0.02 1.50365576E8 7850000.0 0.13 0.0813 0.5983 3178169 Maybridge4_004125 FC(F)(F)C1N(CCc2c1[nH]c3ccccc23)C(=O)CSc4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L12 compound treatment 1.0031343E8 -4.57E7 -0.57 1.71571494E8 2.91E7 0.5 -0.0536 -0.0706 3178170 Maybridge4_004126 FC(F)(F)c1ccc(nc1)N2CCN(CC2)c3ccc(NC(=O)c4cccs4)cn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L13 compound treatment 1.46015279E8 8370.0 0.0 1.59230686E8 1.67E7 0.29 0.2024 0.7074 3064777 Maybridge4_004127 FC(F)(F)c1ccnc(c1)c2ccc(s2)S(=O)(=O)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L14 compound treatment 1.16927537E8 -2.91E7 -0.36 9.2629192E7 -4.99E7 -0.85 -0.8618 -0.928 3064778 Maybridge4_004128 CC1(C)OC(=O)C(=Cc2cccn2c3ccc(cc3)C(F)(F)F)C(=O)O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L15 compound treatment 1.40660239E8 -5350000.0 -0.07 1.4771831E8 5200000.0 0.09 0.0156 0.1396 3178171 Maybridge4_004129 Cc1onc(c1NC(=O)OCCOc2cc(ccn2)C(F)(F)F)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L16 compound treatment 1.55557132E8 9550000.0 0.12 1.5045243E8 7940000.0 0.14 0.1808 0.998 3178172 Maybridge4_004130 CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCN(CC2)c3ccc(cn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L17 compound treatment 1.65673833E8 1.97E7 0.25 1.72463152E8 2.99E7 0.51 0.537 0.9438 1466123 Maybridge4_004131 Clc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L18 compound treatment 1.51490281E8 5480000.0 0.07 8.6904863E7 -5.56E7 -0.95 -0.6245 -0.6543 3178173 Maybridge4_004132 CS(=O)(=O)/C(=C/c1cccn1c2ccc(OC(F)(F)F)cc2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L19 compound treatment 1.55706989E8 9700000.0 0.12 1.05902283E8 -3.66E7 -0.63 -0.3571 -0.5594 3064779 Maybridge4_004133 Clc1ccc(C(=O)n2cc3COCCc3n2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L20 compound treatment 1.48620908E8 2610000.0 0.03 1.43833413E8 1320000.0 0.02 0.0392 0.9835 3178174 Maybridge4_004134 CC(C)(C)c1cc(n(n1)c2ccc(cc2)C(=O)NN)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L21 compound treatment 1.71655785E8 2.56E7 0.32 1.03538598E8 -3.9E7 -0.67 -0.2442 -0.3298 3064780 Maybridge4_004135 OC(=O)CCc1ccc(Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L22 compound treatment 1.40025477E8 -5980000.0 -0.08 1.22033253E8 -2.05E7 -0.35 -0.301 -0.8394 1339700 Maybridge4_004136 Cc1onc(c1c2nc(CSc3nc4ccccc4[nH]3)no2)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L23 mock treatment 1.5905216E8 1.3E7 0.16 9.1907346E7 -5.06E7 -0.87 -0.4968 -0.5636 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 L24 mock treatment 1.22268206E8 -2.37E7 -0.3 1.13567797E8 -2.89E7 -0.5 -0.5609 -0.9703 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M01 compound treatment 9.4619805E7 -5.14E7 -0.64 9.970034E7 -4.28E7 -0.73 -0.974 -0.998 3178175 Maybridge4_004137 CCc1ccc(cc1)S(=O)(=O)NC2CCCCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M02 compound treatment 1.026912E8 -4.33E7 -0.54 1.11369699E8 -3.11E7 -0.53 -0.7612 -1.0 3064835 Maybridge4_004138 CC/1Sc2ccc(Cl)cc2C(=O)\C1=C\N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M03 compound treatment 1.0490039E8 -4.11E7 -0.52 1.27758596E8 -1.48E7 -0.25 -0.5432 -0.9461 3178176 Maybridge4_004139 O=S(=O)(N(Cc1ccccn1)Cc2ccccn2)c3ccc(nc3)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M04 compound treatment 1.20464831E8 -2.55E7 -0.32 1.14596578E8 -2.79E7 -0.48 -0.5645 -0.9811 3064836 Maybridge4_004140 Cn1cnnc1SCc2ccc(cc2)c3csnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M05 compound treatment 1.24686827E8 -2.13E7 -0.27 1.27321255E8 -1.52E7 -0.26 -0.373 -0.9999 3178177 Maybridge4_004141 O=C(N1CCCCCC1)c2ccc(nc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M06 compound treatment 1.25699104E8 -2.03E7 -0.25 1.20732742E8 -2.18E7 -0.37 -0.4438 -0.9828 3064837 Maybridge4_004142 COC(=O)c1cc(C)cc(=O)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M07 compound treatment 1.23966714E8 -2.2E7 -0.28 1.25524502E8 -1.7E7 -0.29 -0.4011 -0.9997 3064839 Maybridge4_004143 Fc1ccc(cc1F)S(=O)(=O)NCc2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M08 compound treatment 1.23849574E8 -2.22E7 -0.28 1.31373445E8 -1.11E7 -0.19 -0.3314 -0.9831 1167482 Maybridge4_004144 Cc1nc(C)c(o1)c2ccnc(n2)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M09 compound treatment 1.14728597E8 -3.13E7 -0.39 1.10464941E8 -3.2E7 -0.55 -0.6654 -0.9865 3178178 Maybridge4_004145 CN(C)c1ccc(cc1)C(=O)NCc2nn(nc2C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M10 compound treatment 1.18792782E8 -2.72E7 -0.34 1.251106E8 -1.74E7 -0.3 -0.452 -0.9977 1335790 Maybridge4_004146 CN(C)c1c(F)cc(cc1F)C(=O)NC(=O)NCc2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M11 compound treatment 1.22620897E8 -2.34E7 -0.29 1.26890561E8 -1.56E7 -0.27 -0.3965 -0.9989 3178179 Maybridge4_004147 COc1ccc(OC)c(c1)S(=O)(=O)NCc2nn(nc2C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M12 compound treatment 1.22535443E8 -2.35E7 -0.29 1.18913111E8 -2.36E7 -0.4 -0.4939 -0.9879 3064841 Maybridge4_004148 CN(C)c1c(/C=C(/C#N)\S(=O)(=O)C)cc(/C=C(/C#N)\S(=O)(=O)C)c(N(C)C)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M13 compound treatment 1.24666402E8 -2.13E7 -0.27 1.40707564E8 -1810000.0 -0.03 -0.2112 -0.7836 3178180 Maybridge4_004149 CSc1nsc(SC)c1C(=O)NC(=O)N2CCSCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M14 compound treatment 1.14780977E8 -3.12E7 -0.39 1.26818428E8 -1.57E7 -0.27 -0.467 -0.9831 1166894 Maybridge4_004150 COC(=O)c1c(C)nc(C)c(C(=O)OC)c1c2csc(c2)S(=O)(=O)N3CCSCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M15 compound treatment 1.2293734E8 -2.31E7 -0.29 1.2109451E8 -2.14E7 -0.37 -0.4639 -0.9931 3064844 Maybridge4_004151 COC(=O)c1sc(cc1CS(=O)(=O)c2cc(C)c(Cl)cc2C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M16 compound treatment 2.70676076E8 1.25E8 1.56 3.0088885E8 1.58E8 2.71 3.0229 0.9658 3178181 Maybridge4_004152 Sc1nccc(n1)c2ccc(s2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M17 compound treatment 1.27358349E8 -1.86E7 -0.23 1.42689364E8 176000.0 0.0 -0.1633 -0.698 1462127 Maybridge4_004153 Fc1ccc(C(=O)Nc2ccc(cc2)c3cnco3)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M18 compound treatment 1.17407924E8 -2.86E7 -0.36 1.24438141E8 -1.81E7 -0.31 -0.4725 -0.9973 3178182 Maybridge4_004154 Cc1ccccc1C(=O)N2CCc3c([nH]c4ccccc34)C2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M19 compound treatment 1.29129779E8 -1.69E7 -0.21 1.3976796E8 -2750000.0 -0.05 -0.1829 -0.8436 1245747 Maybridge4_004155 Clc1ccc(cc1)C2=NCCc3sccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M20 compound treatment 1.23389648E8 -2.26E7 -0.28 1.3883597E8 -3680000.0 -0.06 -0.2451 -0.8435 3178183 Maybridge4_004156 Clc1ccc(OCc2ccsc2Cn3cccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M21 compound treatment 1.17435025E8 -2.86E7 -0.36 1.25261655E8 -1.73E7 -0.3 -0.4623 -0.9954 1431141 Maybridge4_004157 CCCC1N(CCc2sccc12)C(=O)c3cc(OC)cc(OC)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M22 compound treatment 1.24736211E8 -2.13E7 -0.27 1.4283258E8 319000.0 0.01 -0.1848 -0.6925 3178184 Maybridge4_004158 Clc1ccc(SC(=O)c2ccc(s2)c3cccs3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M23 mock treatment 1.23032921E8 -2.3E7 -0.29 1.32247693E8 -1.03E7 -0.18 -0.328 -0.9719 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 M24 mock treatment 1.20861558E8 -2.51E7 -0.32 1.26967936E8 -1.55E7 -0.27 -0.4112 -0.9964 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N01 compound treatment 1.17569723E8 -2.84E7 -0.36 1.23533807E8 -1.9E7 -0.32 -0.482 -0.9989 3064890 Maybridge4_004159 C/C(=N\O)/c1cc(c(s1)C(F)(F)F)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N02 compound treatment 1.21241881E8 -2.48E7 -0.31 1.10235658E8 -3.23E7 -0.55 -0.6104 -0.9629 3178185 Maybridge4_004160 CC(C)(C)c1csc(n1)c2ccc(s2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N03 compound treatment 1.25430305E8 -2.06E7 -0.26 1.29930588E8 -1.26E7 -0.22 -0.3348 -0.996 3064891 Maybridge4_004161 FC(F)(F)c1sc(COC(=O)Nc2ccccc2)cc1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N04 compound treatment 8.7066733E7 -5.89E7 -0.74 8.8500114E7 -5.4E7 -0.92 -1.1766 -0.9939 3178186 Maybridge4_004162 FC(F)(F)c1ccc(Cl)c(c1)c2ccc(o2)C(C3C(=O)CCCC3=O)C4C(=O)CCCC4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N05 compound treatment 1.25070211E8 -2.09E7 -0.26 1.31013627E8 -1.15E7 -0.2 -0.3249 -0.9899 3064893 Maybridge4_004163 COc1ccc(SCc2cc3c(F)c(F)c(F)c(F)c3o2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N06 compound treatment 1.31271093E8 -1.47E7 -0.18 1.23090521E8 -1.94E7 -0.33 -0.3658 -0.9616 3178187 Maybridge4_004164 Cc1noc(C)c1C(=O)n2cc3CSc4ccc(F)cc4-c3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N07 compound treatment 1.12627709E8 -3.34E7 -0.42 1.1109031E8 -3.14E7 -0.54 -0.6764 -0.9923 3064894 Maybridge4_004165 FC(F)(F)/C(=C(\C#N)/c1ccccc1)/Oc2ccc(C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N08 compound treatment 1.05995202E8 -4.0E7 -0.5 1.15993253E8 -2.65E7 -0.45 -0.6759 -0.9987 3178188 Maybridge4_004166 Cc1oc(N)c(c1C)S(=O)(=O)/C(=C/c2cc(Cl)cc(Cl)c2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N09 compound treatment 1.29450395E8 -1.66E7 -0.21 1.2276488E8 -1.97E7 -0.34 -0.3859 -0.9726 3178189 Maybridge4_004167 CCOC(=O)c1ccc2C(=O)/C(=C/c3ccc(Cl)cc3Cl)/CCc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N10 compound treatment 1.37789744E8 -8220000.0 -0.1 1.35952542E8 -6560000.0 -0.11 -0.1523 -0.9991 1967416 Maybridge4_004168 OC(=O)CCC(=O)N1CCN(CC1)c2ncccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N11 compound treatment 1.16412772E8 -2.96E7 -0.37 1.32363259E8 -1.02E7 -0.17 -0.3854 -0.9402 3064896 Maybridge4_004169 Clc1ccc(SCc2csc(n2)c3ccsc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N12 compound treatment 1.25285232E8 -2.07E7 -0.26 1.39179787E8 -3330000.0 -0.06 -0.2242 -0.8423 3178190 Maybridge4_004170 FC(F)(F)c1ccc(nc1)N2CCN(CC2)c3ccc(NC(=O)/C=C/c4ccccc4)cn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N13 compound treatment 1.17637743E8 -2.84E7 -0.36 1.32818166E8 -9700000.0 -0.17 -0.369 -0.9397 3064897 Maybridge4_004171 CN(C)/C=N/C(=S)N1CCOCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N14 compound treatment 1.13893171E8 -3.21E7 -0.4 1.30679904E8 -1.18E7 -0.2 -0.4281 -0.9494 3178191 Maybridge4_004172 OC(=O)C1C(C2CC1C=C2)C(=O)N3CCc4c([nH]c5ccccc45)C3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N15 compound treatment 1.33160495E8 -1.28E7 -0.16 1.31693446E8 -1.08E7 -0.19 -0.2449 -0.9976 1192815 Maybridge4_004173 O=C(NC(=S)Nc1ccncc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N16 compound treatment 1.3059815E8 -1.54E7 -0.19 1.3338543E8 -9130000.0 -0.16 -0.2472 -0.9944 3064898 Maybridge4_004174 CS(=O)(=O)N1CCN(CC1)c2ncccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N17 compound treatment 1.09545281E8 -3.65E7 -0.46 8.7384734E7 -5.51E7 -0.94 -0.9907 -0.9447 1131475 Maybridge4_004175 Clc1ccc(NC(=O)N2CCC(CC2)C(=O)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N18 compound treatment 1.36570454E8 -9440000.0 -0.12 8.0569572E7 -6.19E7 -1.06 -0.8335 -0.7812 1346023 Maybridge4_004176 Cc1ccc(cc1)S(=O)(=O)NC(=O)Oc2ccc(cc2)c3csnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N19 compound treatment 1.24034326E8 -2.2E7 -0.28 1.2727945E8 -1.52E7 -0.26 -0.3793 -0.9996 3178192 Maybridge4_004177 S=C(SCc1ncon1)N2CCSCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N20 compound treatment 1.14913761E8 -3.11E7 -0.39 1.31166074E8 -1.13E7 -0.19 -0.4132 -0.9482 3178193 Maybridge4_004178 Cc1ccc(C)n1CCSCc2c(C)cc(C)cc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N21 compound treatment 1.17030616E8 -2.9E7 -0.36 7.3589385E7 -6.89E7 -1.18 -1.0913 -0.884 1202142 Maybridge4_004179 CCOC(=O)c1c(C)nn(c1C)c2ncccc2NC(=O)CCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N22 compound treatment 1.21739936E8 -2.43E7 -0.3 1.2055684E8 -2.2E7 -0.38 -0.481 -0.9945 1591050 Maybridge4_004180 CCOC(=O)c1[nH]c2ccc(cc2c1CCC(=O)O)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N23 mock treatment 1.24346016E8 -2.17E7 -0.27 1.2781001E8 -1.47E7 -0.25 -0.3701 -0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 N24 mock treatment 1.17655643E8 -2.84E7 -0.36 1.30086598E8 -1.24E7 -0.21 -0.4019 -0.9698 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O01 compound treatment 1.05154461E8 -4.09E7 -0.51 1.02414527E8 -4.01E7 -0.69 -0.8477 -0.9896 3178270 Maybridge4_004181 COc1cc2CCN(Cc2cc1OC)C(=O)c3sc(nc3C)c4cnccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O02 compound treatment 1.08590096E8 -3.74E7 -0.47 1.05307169E8 -3.72E7 -0.64 -0.7823 -0.9887 1317839 Maybridge4_004182 CC(C)(C)c1ccc(s1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O03 compound treatment 9.6544473E7 -4.95E7 -0.62 9.9307616E7 -4.32E7 -0.74 -0.9617 -0.9962 3064900 Maybridge4_004183 COc1ccc(cc1)n2ncc(C(=O)Nc3ccc4nccnc4c3)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O04 compound treatment 1.0755387E8 -3.85E7 -0.48 1.00719223E8 -4.18E7 -0.72 -0.847 -0.9816 3178271 Maybridge4_004184 N/C(=N/O)/c1cnc2SCCn2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O05 compound treatment 1.19589107E8 -2.64E7 -0.33 1.16352231E8 -2.62E7 -0.45 -0.551 -0.989 3178272 Maybridge4_004185 O=C(N1CCSCC1)c2ccc(nc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O06 compound treatment 1.24673525E8 -2.13E7 -0.27 1.20601225E8 -2.19E7 -0.38 -0.4545 -0.9863 3064901 Maybridge4_004186 NC(=S)c1ccc(cc1Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O07 compound treatment 1.1451494E8 -3.15E7 -0.4 1.23921061E8 -1.86E7 -0.32 -0.5044 -0.9943 3178273 Maybridge4_004187 O=S(=O)(NCc1ccc(cc1)c2cccs2)c3ccc(nc3)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O08 compound treatment 1.03261351E8 -4.27E7 -0.54 9.7132265E7 -4.54E7 -0.78 -0.9285 -0.9836 3064932 Maybridge4_004188 CN(C)c1ccc(/C=C(\C#N)/S(=O)(=O)C)c(F)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O09 compound treatment 1.13291571E8 -3.27E7 -0.41 1.10675815E8 -3.18E7 -0.54 -0.6756 -0.9902 3178274 Maybridge4_004189 Cc1nn(nc1CNC(=O)c2cccs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O10 compound treatment 1.07075849E8 -3.89E7 -0.49 1.08798772E8 -3.37E7 -0.58 -0.7534 -0.9965 3178275 Maybridge4_004190 CN(C)c1c(F)cc(cc1F)C(=O)NC(=O)NC2=NCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O11 compound treatment 1.17543392E8 -2.85E7 -0.36 1.13701224E8 -2.88E7 -0.49 -0.6012 -0.9874 3064933 Maybridge4_004191 Cc1noc(C)c1NC(=O)NCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O12 compound treatment 1.21202965E8 -2.48E7 -0.31 1.20119949E8 -2.24E7 -0.38 -0.4911 -0.9946 3064934 Maybridge4_004192 NNC(=O)c1cc2sccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O13 compound treatment 1.17922832E8 -2.81E7 -0.35 1.10756949E8 -3.18E7 -0.54 -0.6335 -0.978 3178276 Maybridge4_004193 CSc1nsc(SC)c1C(=O)NC(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O14 compound treatment 1.11497546E8 -3.45E7 -0.43 1.09704793E8 -3.28E7 -0.56 -0.7032 -0.9917 1408005 Maybridge4_004194 COC(=O)c1c(C)nc(C)c(C(=O)OC)c1c2csc(c2)S(=O)(=O)Nc3ccc(OC)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O15 compound treatment 1.1654554E8 -2.95E7 -0.37 1.14470309E8 -2.8E7 -0.48 -0.6008 -0.9917 3064936 Maybridge4_004195 COC(=O)c1sc(cc1CS(=O)(=O)c2ccccn2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O16 compound treatment 1.15542101E8 -3.05E7 -0.38 1.24539458E8 -1.8E7 -0.31 -0.4878 -0.9942 3178277 Maybridge4_004196 COc1ccc(cc1OC)S(=O)(=O)n2nccc2c3ccc(s3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O17 compound treatment 1.19332785E8 -2.67E7 -0.33 1.21199366E8 -2.13E7 -0.36 -0.4946 -0.9991 3064939 Maybridge4_004197 Clc1ccc(NC(=S)Nc2ccc(cc2)c3csnn3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O18 compound treatment 1.09123948E8 -3.69E7 -0.46 1.1132103E8 -3.12E7 -0.53 -0.7047 -0.9975 3178278 Maybridge4_004198 Clc1cccc(Cl)c1C(=O)NCc2ccc(s2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O19 compound treatment 1.18765907E8 -2.72E7 -0.34 1.15893796E8 -2.66E7 -0.46 -0.5639 -0.9899 3064941 Maybridge4_004199 CNC(=S)N1CCc2sccc2C1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O20 compound treatment 1.20158501E8 -2.58E7 -0.32 1.2395735E8 -1.86E7 -0.32 -0.4539 -0.9999 3178279 Maybridge4_004200 CS/C(=N\C#N)/NCc1sccc1COc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O21 compound treatment 1.12746502E8 -3.33E7 -0.42 1.14520069E8 -2.8E7 -0.48 -0.6339 -0.9976 1659450 Maybridge4_004201 O=C(NC(=O)c1ccc(cc1)c2csnn2)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O22 compound treatment 1.03732482E8 -4.23E7 -0.53 1.08910724E8 -3.36E7 -0.58 -0.7817 -0.9992 3178280 Maybridge4_004202 CN(C)/C=N\C(=S)c1sccc1CSc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O23 mock treatment 1.15496515E8 -3.05E7 -0.38 1.0486324E8 -3.77E7 -0.64 -0.7264 -0.969 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 O24 mock treatment 1.19005909E8 -2.7E7 -0.34 1.15039546E8 -2.75E7 -0.47 -0.5721 -0.987 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P01 compound treatment 1.1556813E8 -3.04E7 -0.38 1.17124033E8 -2.54E7 -0.43 -0.5773 -0.9979 1411380 Maybridge4_004203 COC(=O)c1cc(=O)n2ccccc2c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P02 compound treatment 1.58354237E8 1.23E7 0.15 1.59495621E8 1.7E7 0.29 0.3151 0.9566 3178281 Maybridge4_004204 CN(C)/C=N/C(=S)c1ccc(s1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P03 compound treatment 1.13557611E8 -3.24E7 -0.41 1.15380439E8 -2.71E7 -0.46 -0.6163 -0.9978 3178282 Maybridge4_004205 CCOC(=O)c1c(CS(=O)(=O)Cc2ccc(Cl)cc2)oc3c(F)c(F)c(F)c(F)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P04 compound treatment 9.4616992E7 -5.14E7 -0.64 1.02600067E8 -3.99E7 -0.68 -0.939 -0.9996 1195874 Maybridge4_004206 COc1ccc(CN(Cc2cc(OC)c(OC)c(OC)c2)C(=O)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P05 compound treatment 9.5022981E7 -5.1E7 -0.64 1.05445661E8 -3.71E7 -0.63 -0.9009 -1.0 3178283 Maybridge4_004207 COC(=O)c1sc(c(c1S(=O)(=O)NC(C)(C)C)c2ccccc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P06 compound treatment 7.7232772E7 -6.88E7 -0.86 8.0139361E7 -6.24E7 -1.07 -1.365 -0.9944 3064943 Maybridge4_004208 OC1=C(C(=O)c2ccccc12)c3cc(Cl)cc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P07 compound treatment 7.1756261E7 -7.43E7 -0.93 7.9658046E7 -6.29E7 -1.08 -1.4194 -0.9974 3064944 Maybridge4_004209 CSc1ccc(/C=C\2/C(=NN(C)C2=O)C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P08 compound treatment 1.03037509E8 -4.3E7 -0.54 1.16405274E8 -2.61E7 -0.45 -0.6972 -0.9957 1179765 Maybridge4_004210 Cc1noc(C)c1NC(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P09 compound treatment 1.03045989E8 -4.3E7 -0.54 1.11079866E8 -3.14E7 -0.54 -0.7616 -1.0 3064945 Maybridge4_004211 FC(F)(F)Oc1ccc(NC(=O)C=C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P10 compound treatment 9.6155381E7 -4.99E7 -0.63 9.9383952E7 -4.31E7 -0.74 -0.9643 -0.9966 3178284 Maybridge4_004212 CC(C)(C)SCc1cccc(c1)C(=O)N2CCN(CC2)c3ncccc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P11 compound treatment 1.05225757E8 -4.08E7 -0.51 1.10580161E8 -3.19E7 -0.55 -0.7483 -0.9995 3178285 Maybridge4_004213 OC(=O)c1cccnc1C(=O)N2CCc3c([nH]c4ccccc34)C2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P12 compound treatment 1.20950923E8 -2.51E7 -0.31 1.15571377E8 -2.69E7 -0.46 -0.5484 -0.9825 3178286 Maybridge4_004214 O/N=C/c1ccc(Cl)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P13 compound treatment 1.02621937E8 -4.34E7 -0.54 1.10034731E8 -3.25E7 -0.56 -0.778 -0.9999 3178287 Maybridge4_004215 CC(C)(C)NC(=O)N1CCN(CC1)c2cc(ccn2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P14 compound treatment 9.0248227E7 -5.58E7 -0.7 9.7824896E7 -4.47E7 -0.76 -1.0355 -0.999 3064989 Maybridge4_004216 FC(F)(F)C1N(CCc2c1[nH]c3ccccc23)C(=S)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P15 compound treatment 1.23028066E8 -2.3E7 -0.29 1.23382068E8 -1.91E7 -0.33 -0.4354 -0.998 3178288 Maybridge4_004217 CN(C(=S)NC(=O)c1ccccc1)c2ccc(OC(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P16 compound treatment 1.0818093E8 -3.78E7 -0.47 1.06407653E8 -3.61E7 -0.62 -0.7726 -0.9915 3064991 Maybridge4_004218 FC(F)(F)c1ccc(nc1)N2CCN(CC2)C(=O)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P17 compound treatment 1.14516085E8 -3.15E7 -0.4 9.3928018E7 -4.86E7 -0.83 -0.8674 -0.9421 3178289 Maybridge4_004219 Cc1cc(C)n(n1)c2ccc(cc2)n3cccc3/C=C(/C#N)\S(=O)(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P18 compound treatment 1.14820764E8 -3.12E7 -0.39 9.1473935E7 -5.1E7 -0.87 -0.8944 -0.9343 3178290 Maybridge4_004220 OC(=O)CCCC(=O)Nc1ccccc1SCc2noc(n2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P19 compound treatment 1.17510011E8 -2.85E7 -0.36 1.31666285E8 -1.08E7 -0.19 -0.3841 -0.9534 1467411 Maybridge4_004221 Fc1ccc(CSC(=S)N2CCN(CC2)C(=S)SCc3ccc(F)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P20 compound treatment 1.08661545E8 -3.73E7 -0.47 1.14465517E8 -2.8E7 -0.48 -0.6708 -0.9999 3064993 Maybridge4_004222 CC(C)n1nc(cc1C(C)(C)C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P21 compound treatment 1.00240641E8 -4.58E7 -0.57 1.02227312E8 -4.03E7 -0.69 -0.8936 -0.9958 3178291 Maybridge4_004223 Cn1nc(c(c1N2C(=O)C3C4CC(C=C4)C3C2=O)c5ccccc5)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P22 compound treatment 9.6736407E7 -4.93E7 -0.62 1.01148697E8 -4.14E7 -0.71 -0.9377 -0.9977 3178292 Maybridge4_004224 COC(=O)c1cc(/C=C/C(=O)N(C2CCCCC2)C(=O)NC3CCCCC3)cn1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P23 mock treatment 1.12766407E8 -3.32E7 -0.42 1.08956037E8 -3.36E7 -0.57 -0.701 -0.9876 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2060 P24 mock treatment 1.13078467E8 -3.29E7 -0.41 1.11007146E8 -3.15E7 -0.54 -0.6734 -0.9913 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A01 compound treatment 1.75351929E8 1.88E7 0.24 1.74141517E8 3.17E7 0.54 0.5507 0.9307 1382867 Maybridge4_004225 C1Oc2ccc(cc2O1)C3Nc4ccccc4S3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A02 compound treatment 1.6319392E8 6680000.0 0.08 1.61287443E8 1.88E7 0.32 0.2873 0.8622 3064994 Maybridge4_004226 CN(C)C(=O)Oc1nnc(SCc2ccc(C)cc2)n1c3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A03 compound treatment 1.77861464E8 2.13E7 0.27 1.74676395E8 3.22E7 0.55 0.5795 0.9449 1421127 Maybridge4_004227 Cc1c(cc(c2ccccc2)n1c3ccccc3)C(=O)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A04 compound treatment 1.83022963E8 2.65E7 0.33 1.67068388E8 2.46E7 0.42 0.5332 0.9931 3178293 Maybridge4_004228 CC(C)Sc1nnc(OC(=O)N(C)C)n1c2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A05 compound treatment 1.80210571E8 2.37E7 0.3 1.71317064E8 2.89E7 0.49 0.5596 0.9704 1234864 Maybridge4_004229 N#Cc1ccc(cc1)c2csc(n2)c3ccc(cc3)C4SCCS4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A06 compound treatment 1.8491815E8 2.84E7 0.36 1.84028244E8 4.16E7 0.71 0.7552 0.9488 3178294 Maybridge4_004230 CSc1nnc(O)c2cc(C)nn12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A07 compound treatment 1.77947841E8 2.14E7 0.27 1.75689914E8 3.32E7 0.57 0.5925 0.9414 3064995 Maybridge4_004231 Cc1ccc(cc1)c2csc(COC(=O)C(C)(C)C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A08 compound treatment 1.77616301E8 2.11E7 0.26 1.79254153E8 3.68E7 0.63 0.6327 0.9258 3178295 Maybridge4_004232 Fc1ccc(Cn2ccnc2c3ccc(cc3)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A09 compound treatment 1.76606492E8 2.01E7 0.25 1.78338995E8 3.59E7 0.61 0.6127 0.9226 3064997 Maybridge4_004233 CCn1nc(C)c(Br)c1c2nc(no2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A10 compound treatment 1.61294345E8 4780000.0 0.06 1.64771861E8 2.23E7 0.38 0.3126 0.8082 3178296 Maybridge4_004234 Cc1nc(C)c(s1)c2nnc(S)n2c3ccccc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A11 compound treatment 1.51415974E8 -5100000.0 -0.06 1.5778314E8 1.53E7 0.26 0.1404 0.5197 1124397 Maybridge4_004235 Cc1oc(cc1c2cc(N)n(n2)c3ccc(cc3)S(=O)(=O)N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A12 compound treatment 1.41055998E8 -1.55E7 -0.19 1.62193974E8 1.97E7 0.34 0.1019 0.2615 3064998 Maybridge4_004236 Cn1c(SCc2ccc(cc2)C(F)(F)F)nnc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A13 compound treatment 1.58634584E8 2120000.0 0.03 1.45965669E8 3520000.0 0.06 0.0614 0.9326 3178384 Maybridge4_004237 Cc1n(CCSCc2c(F)cccc2Cl)c(c3ccccc3)c4cn[nH]c(=O)c14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A14 compound treatment 1.65183325E8 8670000.0 0.11 1.55562151E8 1.31E7 0.22 0.2356 0.9447 1628717 Maybridge4_004238 NNC(=O)c1csc(Cc2c(Cl)cccc2Cl)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A15 compound treatment 1.53160641E8 -3350000.0 -0.04 1.58221385E8 1.58E7 0.27 0.1612 0.5898 3064999 Maybridge4_004239 CCN(CC)c1cnn(c2ccc(cc2)C(F)(F)F)c(=O)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A16 compound treatment 1.6927062E8 1.28E7 0.16 1.60647484E8 1.82E7 0.31 0.3334 0.9521 1426168 Maybridge4_004240 NNC(=O)c1csc(COc2cc(Cl)cc(Cl)c2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A17 compound treatment 1.87161655E8 3.06E7 0.38 1.62690942E8 2.02E7 0.35 0.5169 0.9987 1381395 Maybridge4_004241 COC(=O)c1ccc(o1)S(=O)(=O)NCc2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A18 compound treatment 1.73452893E8 1.69E7 0.21 1.62167399E8 1.97E7 0.34 0.3889 0.9751 3065000 Maybridge4_004242 CC(C)n1c(S)nc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A19 compound treatment 1.707112E8 1.42E7 0.18 1.5872431E8 1.63E7 0.28 0.3229 0.9766 3065124 Maybridge4_004243 CC(C)(C)c1nnc(S)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A20 compound treatment 1.65800957E8 9290000.0 0.12 1.56989846E8 1.45E7 0.25 0.2584 0.9402 1241496 Maybridge4_004244 CC(C)(C)c1ccc(cc1)c2noc(CCn3c(=O)oc4ccccc34)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A21 compound treatment 1.73743095E8 1.72E7 0.22 1.61220764E8 1.88E7 0.32 0.3801 0.9814 3178385 Maybridge4_004245 CC(Oc1ccc(Cl)cc1Cl)/C(=N/O)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A22 compound treatment 1.70124146E8 1.36E7 0.17 1.59922328E8 1.75E7 0.3 0.3322 0.9646 3178386 Maybridge4_004246 Cc1cc(no1)c2nnc(o2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A23 mock treatment 1.65843578E8 9330000.0 0.12 1.67408531E8 2.5E7 0.43 0.3849 0.8688 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 A24 mock treatment 1.81174997E8 2.47E7 0.31 1.6453637E8 2.21E7 0.38 0.4861 0.995 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B01 compound treatment 1.78013319E8 2.15E7 0.27 1.05986937E8 -3.65E7 -0.62 -0.2506 -0.3686 3065125 Maybridge4_004247 Cc1nc(sc1C(=O)Sc2ccc(C)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B02 compound treatment 1.9866506E8 4.22E7 0.53 1.05369803E8 -3.71E7 -0.63 -0.0749 -0.0907 3178387 Maybridge4_004248 CCOC(=O)c1cc2c(NCc3ccc(Cl)cc3Cl)nccc2nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B03 compound treatment 2.00498704E8 4.4E7 0.55 1.04529703E8 -3.79E7 -0.65 -0.0688 -0.0808 3065126 Maybridge4_004249 NNC(=O)c1ccc(Oc2cc(Cl)cc(Cl)c2)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B04 compound treatment 1.31886281E8 -2.46E7 -0.31 9.7995779E7 -4.45E7 -0.76 -0.7565 -0.9212 3178388 Maybridge4_004250 CCOC(=O)c1cc(on1)c2ccnn2S(=O)(=O)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B05 compound treatment 1.04321773E8 -5.22E7 -0.65 1.00935255E8 -4.15E7 -0.71 -0.9654 -0.9992 1700962 Maybridge4_004251 COC(=O)c1c(C)nn(C(=O)c2ccc(C)cc2)c1c3cc(C)on3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B06 compound treatment 2.0425004E8 4.77E7 0.6 1.06186911E8 -3.63E7 -0.62 -0.0155 -0.0179 3178389 Maybridge4_004252 Cc1nc2ccccn2c1c3ccnc(S)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B07 compound treatment 2.19339906E8 6.28E7 0.79 9.620839E7 -4.62E7 -0.79 -0.0024 -0.0022 3065128 Maybridge4_004253 Cc1nc(cs1)c2c(C)onc2C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B08 compound treatment 2.04167183E8 4.77E7 0.6 1.18475041E8 -2.4E7 -0.41 0.1325 0.1828 3178390 Maybridge4_004254 CC(O)c1cc(no1)c2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B09 compound treatment 1.23783772E8 -3.27E7 -0.41 9.6827509E7 -4.56E7 -0.78 -0.8425 -0.9549 3065129 Maybridge4_004255 CN(C)/C=C/C(=O)c1csc(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B10 compound treatment 1.60047045E8 3530000.0 0.04 1.12087734E8 -3.04E7 -0.52 -0.3362 -0.6445 3065175 Maybridge4_004256 Cc1onc(c1c2ccnn2C(=O)c3ccc(Cl)cc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B11 compound treatment 1.26274165E8 -3.02E7 -0.38 8.6125467E7 -5.63E7 -0.96 -0.95 -0.9169 3178391 Maybridge4_004257 Cc1ccc(cc1)C(=O)Sc2ncc(cc2Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B12 compound treatment 1.52700981E8 -3810000.0 -0.05 1.0188734E8 -4.06E7 -0.69 -0.5248 -0.754 3065177 Maybridge4_004258 COC(OC)c1nc(SCC#N)c(C#N)cc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B13 compound treatment 1.95454082E8 3.89E7 0.49 1.161668E8 -2.63E7 -0.45 0.0273 0.0411 3178392 Maybridge4_004259 Cc1nn(C(=O)c2ccc(Cl)cc2)c(C)c1Sc3nnc(n3C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B14 compound treatment 2.04642874E8 4.81E7 0.6 1.1866709E8 -2.38E7 -0.41 0.1391 0.191 3065178 Maybridge4_004260 Cc1nccc(n1)c2cc(no2)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B15 compound treatment 1.75540725E8 1.9E7 0.24 1.53342681E8 1.09E7 0.19 0.3006 0.9925 3178393 Maybridge4_004261 FC(F)(F)c1ccc(cc1)n2ccc(=O)c(n2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B16 compound treatment 1.69468776E8 1.3E7 0.16 8.9353322E7 -5.31E7 -0.91 -0.5278 -0.5716 3065180 Maybridge4_004262 Cc1noc2ncnc(SCC(=O)Nc3cc(Cl)cc(Cl)c3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B17 compound treatment 1.20596146E8 -3.59E7 -0.45 1.13244546E8 -2.92E7 -0.5 -0.6721 -0.9987 3178394 Maybridge4_004263 Cn1c(SCC(=O)c2ccccc2)nnc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B18 compound treatment 1.17859025E8 -3.87E7 -0.48 9.9835702E7 -4.26E7 -0.73 -0.8587 -0.9803 1443847 Maybridge4_004264 COc1ccc(cc1)c2csc(n2)c3c(C)noc3N(C(=O)C)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B19 compound treatment 1.09487823E8 -4.7E7 -0.59 9.5509801E7 -4.69E7 -0.8 -0.9853 -0.9885 3065181 Maybridge4_004265 COCc1nc(SCC(=O)OC)c(C#N)cc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B20 compound treatment 1.95790986E8 3.93E7 0.49 1.10928926E8 -3.15E7 -0.54 -0.0331 -0.0453 3178395 Maybridge4_004266 Cn1c(SCC(=O)c2ccc(Cl)cc2)nnc1c3ncc(cc3Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B21 compound treatment 1.73497671E8 1.7E7 0.21 1.0036851E8 -4.21E7 -0.72 -0.3587 -0.4775 3065182 Maybridge4_004267 Cc1ccc(CSc2cnc(C)nc2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B22 compound treatment 1.38615163E8 -1.79E7 -0.22 1.65855242E8 2.34E7 0.4 0.1246 0.2712 1614331 Maybridge4_004268 CSc1nc(COc2ccc(cc2)C(C)(C)C)nc(c1C#N)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B23 mock treatment 1.78235073E8 2.17E7 0.27 1.10733228E8 -3.17E7 -0.54 -0.1912 -0.3148 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 B24 mock treatment 1.7354847E8 1.7E7 0.21 1.76026304E8 3.36E7 0.57 0.5575 0.9092 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C01 compound treatment 1.30389688E8 -2.61E7 -0.33 1.3363707E8 -8810000.0 -0.15 -0.3384 -0.938 3065184 Maybridge4_004269 COc1cc(/C=C(\C#N)/c2ccc(C)cc2)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C02 compound treatment 1.60440704E8 3930000.0 0.05 1.50180883E8 7730000.0 0.13 0.1284 0.9094 1173149 Maybridge4_004270 CN(C)C(=O)n1c(SCc2ccccc2)nnc1c3ccc(cc3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C03 compound treatment 1.33617159E8 -2.29E7 -0.29 1.33492763E8 -8960000.0 -0.15 -0.3115 -0.9568 3065185 Maybridge4_004271 Cc1c(cc(c2ccccc2)n1CCSc3cc(nc4ccccc34)C(F)(F)F)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C04 compound treatment 1.48819158E8 -7690000.0 -0.1 1.47106146E8 4660000.0 0.08 -0.0119 -0.0949 3178396 Maybridge4_004272 CN/C(=C(\C(=O)OC)/C(=O)c1ccc(Cl)cc1Cl)/C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C05 compound treatment 1.59414434E8 2900000.0 0.04 1.54724354E8 1.23E7 0.21 0.1743 0.8174 1218418 Maybridge4_004273 CCOC(=O)c1cc(n(c1C)c2ccc(cc2)N3CCOCC3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C06 compound treatment 1.51824241E8 -4690000.0 -0.06 1.55720149E8 1.33E7 0.23 0.119 0.5073 3065186 Maybridge4_004274 CCOC(=O)c1cc(C)nn1C(=O)c2c(F)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C07 compound treatment 1.64125751E8 7610000.0 0.1 1.55251592E8 1.28E7 0.22 0.2225 0.9307 3178397 Maybridge4_004275 CCOC(=O)Cc1csc(n1)c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C08 compound treatment 1.56840012E8 327000.0 0.0 1.53990807E8 1.15E7 0.2 0.1426 0.7216 3065189 Maybridge4_004276 C/N=c/1\scc(C)n1NC(=O)Nc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C09 compound treatment 1.40476423E8 -1.6E7 -0.2 1.43512796E8 1060000.0 0.02 -0.1294 -0.6405 1159039 Maybridge4_004277 CSCCn1c(C)c(cc1c2ccccc2)C(=O)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C10 compound treatment 1.44162908E8 -1.24E7 -0.15 1.3444544E8 -8000000.0 -0.14 -0.2064 -0.9981 3178398 Maybridge4_004278 CN(C)/C=N/c1sc(C)c(C)c1C(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C11 compound treatment 1.38419189E8 -1.81E7 -0.23 1.4233404E8 -115000.0 0.0 -0.1619 -0.7132 1508854 Maybridge4_004279 Cc1oc(cc1c2cc(N)n(n2)c3ccc(I)cc3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C12 compound treatment 1.48667568E8 -7850000.0 -0.1 1.40419539E8 -2030000.0 -0.03 -0.0942 -0.9021 3178399 Maybridge4_004280 FC(F)(F)c1ccc(CS(=O)(=O)c2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C13 compound treatment 1.4095302E8 -1.56E7 -0.2 1.3932555E8 -3120000.0 -0.05 -0.1758 -0.8688 3065228 Maybridge4_004281 CCOC(=O)c1c(C)n(c(C)c1S(=O)(=O)Nc2ccc(Cl)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C14 compound treatment 1.51468185E8 -5040000.0 -0.06 1.5127835E8 8830000.0 0.15 0.0621 0.3791 1718696 Maybridge4_004282 NNC(=O)c1csc(CS(=O)(=O)c2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C15 compound treatment 1.43583842E8 -1.29E7 -0.16 1.44431843E8 1980000.0 0.03 -0.0907 -0.5473 3065230 Maybridge4_004283 Clc1ccc(OCc2nc(CSc3cccs3)no2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C16 compound treatment 1.4380721E8 -1.27E7 -0.16 1.36518368E8 -5930000.0 -0.1 -0.1845 -0.9763 3178400 Maybridge4_004284 CCOC(=O)c1csc(n1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C17 compound treatment 1.41905024E8 -1.46E7 -0.18 1.27567581E8 -1.49E7 -0.25 -0.3097 -0.9869 3178401 Maybridge4_004285 OC1(CC(=NN1)/C=C/c2ccc3OCOc3c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C18 compound treatment 1.14154682E8 -4.24E7 -0.53 1.14364479E8 -2.81E7 -0.48 -0.7157 -0.9988 3065232 Maybridge4_004286 CCn1nc(C)cc1C(=O)Sc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C19 compound treatment 1.52285185E8 -4230000.0 -0.05 1.42371877E8 -77000.0 0.0 -0.0384 -0.7245 3065234 Maybridge4_004287 CC(C)(C)c1nnc(SCC=C)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C20 compound treatment 1.53586951E8 -2930000.0 -0.04 1.49532743E8 7080000.0 0.12 0.0598 0.4719 1140041 Maybridge4_004288 CCOC(=O)c1sc(nc1OCc2c(Cl)cccc2Cl)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C21 compound treatment 1.41418896E8 -1.51E7 -0.19 1.45127289E8 2680000.0 0.05 -0.1015 -0.5208 3065235 Maybridge4_004289 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nc(S)n[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C22 compound treatment 1.47633855E8 -8880000.0 -0.11 1.47298124E8 4850000.0 0.08 -0.0201 -0.1444 3178402 Maybridge4_004290 Oc1nnc(SCc2nnc(o2)c3ccc(Cl)cc3)n1C4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C23 mock treatment 1.5139269E8 -5120000.0 -0.06 1.42882897E8 434000.0 0.01 -0.0402 -0.6212 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 C24 mock treatment 1.58979985E8 2470000.0 0.03 1.46922255E8 4470000.0 0.08 0.076 0.9205 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D01 compound treatment 1.55185159E8 -1330000.0 -0.02 1.41985403E8 -463000.0 -0.01 -0.0174 -0.9424 3178403 Maybridge4_004291 Cc1nc(sc1C(=O)Sc2ccc(Cl)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D02 compound treatment 1.61068847E8 4560000.0 0.06 9.59519E7 -4.65E7 -0.8 -0.5224 -0.6547 3065236 Maybridge4_004292 ON/C=N\c1nonc1c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D03 compound treatment 1.57477317E8 964000.0 0.01 1.29424465E8 -1.3E7 -0.22 -0.1491 -0.6678 3178404 Maybridge4_004293 CC(C)(C)c1nnc(o1)c2ccc(Oc3cc(Cl)cc(Cl)c3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D04 compound treatment 1.66082369E8 9570000.0 0.12 1.48716631E8 6270000.0 0.11 0.1607 0.9984 1440627 Maybridge4_004294 CCOC(=O)c1c(C)noc1c2csc(Nc3c(C)cc(C)cc3C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D05 compound treatment 1.13201634E8 -4.33E7 -0.54 1.48257597E8 5810000.0 0.1 -0.3139 -0.5683 3178405 Maybridge4_004295 FC(F)(F)Oc1ccc(cc1)c2noc(NC(=O)Nc3cccc(Cl)c3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D06 compound treatment 1.67457432E8 1.09E7 0.14 1.50716857E8 8270000.0 0.14 0.1972 0.9999 3065237 Maybridge4_004296 CCOC(=O)c1cc(on1)c2ccnn2S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D07 compound treatment 1.76584059E8 2.01E7 0.25 1.55534655E8 1.31E7 0.22 0.3364 0.9983 3178406 Maybridge4_004297 CC(C)(C)C(=O)CSc1nnc(o1)c2cc(OCC(F)(F)F)ccc2OCC(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D08 compound treatment 1.87297048E8 3.08E7 0.39 1.03337853E8 -3.91E7 -0.67 -0.2003 -0.2592 1286523 Maybridge4_004298 Clc1cc(Cl)cc(OCc2nc(cs2)c3cc(no3)c4ccccc4)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D09 compound treatment 1.46238663E8 -1.03E7 -0.13 1.5316928E8 1.07E7 0.18 0.0386 0.1722 3178492 Maybridge4_004299 Cc1cc(no1)c2onc(C)c2C(=O)NC(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D10 compound treatment 1.5702265E8 509000.0 0.01 1.46490926E8 4040000.0 0.07 0.0534 0.7691 3065285 Maybridge4_004300 Cc1onc(c1c2ccnn2S(=O)(=O)c3ccc(Cl)cc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D11 compound treatment 1.56679259E8 166000.0 0.0 1.40580915E8 -1870000.0 -0.03 -0.0211 -0.6596 3178493 Maybridge4_004301 Cc1ccc(CSc2ncc(cc2Cl)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D12 compound treatment 1.72328882E8 1.58E7 0.2 1.52232737E8 9780000.0 0.17 0.2587 0.9964 3065286 Maybridge4_004302 Cc1onc(c1c2ccnc(S)n2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D13 compound treatment 1.62329459E8 5820000.0 0.07 1.6989422E8 2.74E7 0.47 0.3838 0.8072 3178494 Maybridge4_004303 Cc1cc(no1)C(=O)NN2C3CSC2CS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D14 compound treatment 1.53790131E8 -2720000.0 -0.03 1.5902137E8 1.66E7 0.28 0.1764 0.6175 3178495 Maybridge4_004304 CC(=O)Nc1nccc(n1)c2cc(no2)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D15 compound treatment 1.58768852E8 2260000.0 0.03 1.50383058E8 7930000.0 0.14 0.116 0.8365 3065290 Maybridge4_004305 CN(C)C(=O)Oc1nc(nc(C)c1Oc2cccc(c2)C(F)(F)F)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D16 compound treatment 1.61128456E8 4620000.0 0.06 1.43998938E8 1550000.0 0.03 0.0597 0.9374 3178496 Maybridge4_004306 Cc1noc2ncnc(SCc3ccc(Cl)cc3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D17 compound treatment 1.59695332E8 3180000.0 0.04 1.86347175E8 4.39E7 0.75 0.5596 0.7436 3065291 Maybridge4_004307 Cn1ccnc1SCC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D18 compound treatment 1.58474192E8 1960000.0 0.02 1.53096236E8 1.06E7 0.18 0.1463 0.7953 1501067 Maybridge4_004308 CCOC(=O)c1cnc(COc2ccc(cc2)C(C)(C)C)nc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D19 compound treatment 1.63625329E8 7110000.0 0.09 1.48454155E8 6010000.0 0.1 0.1358 0.9975 3065292 Maybridge4_004309 Cc1c(Sc2ccc(Cl)cc2)cnn1C(=O)Nc3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D20 compound treatment 1.54874976E8 -1640000.0 -0.02 1.38099312E8 -4350000.0 -0.07 -0.0672 -0.8698 3178497 Maybridge4_004310 FC(F)(F)c1cnc(c2nnc(SCC#N)n2c3ccc(Cl)cc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D21 compound treatment 1.72183042E8 1.57E7 0.2 1.58189922E8 1.57E7 0.27 0.3295 0.988 3178498 Maybridge4_004311 Cc1ccc(CSc2nc(C)c(Oc3cccc(c3)C(F)(F)F)c(=O)n2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D22 compound treatment 1.49041075E8 -7470000.0 -0.09 1.50112963E8 7660000.0 0.13 0.0265 0.1643 3065294 Maybridge4_004312 FC(F)(F)C1CCN(CC1)C(=O)Nc2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D23 mock treatment 1.40980712E8 -1.55E7 -0.19 1.45437671E8 2990000.0 0.05 -0.1016 -0.5043 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 D24 mock treatment 1.45419487E8 -1.11E7 -0.14 1.3932642E8 -3120000.0 -0.05 -0.1362 -0.9136 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E01 compound treatment 1.16276172E8 -4.02E7 -0.5 1.11696034E8 -3.08E7 -0.53 -0.7292 -0.9998 3065295 Maybridge4_004313 CSc1scc(N)c1S(=O)(=O)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E02 compound treatment 1.23358048E8 -3.32E7 -0.42 1.15603492E8 -2.68E7 -0.46 -0.619 -0.9988 3178499 Maybridge4_004314 Cc1cc(nn1C)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E03 compound treatment 1.23260049E8 -3.33E7 -0.42 1.16116712E8 -2.63E7 -0.45 -0.6137 -0.9993 3178500 Maybridge4_004315 Cc1c(cc(c2ccccc2)n1CCSCc3c(F)cccc3Cl)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E04 compound treatment 1.31853919E8 -2.47E7 -0.31 1.31449032E8 -1.1E7 -0.19 -0.3519 -0.9717 3065296 Maybridge4_004316 C(Oc1ccc(cc1)C2SCCS2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E05 compound treatment 1.33477008E8 -2.3E7 -0.29 1.33917233E8 -8530000.0 -0.15 -0.3076 -0.95 1532983 Maybridge4_004317 Clc1ccc(cc1Cl)c2csc(CC#N)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E06 compound treatment 1.24810735E8 -3.17E7 -0.4 1.26047449E8 -1.64E7 -0.28 -0.4797 -0.9855 3178501 Maybridge4_004318 Cc1cc(CSc2cc(C)c(Cl)cc2C)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E07 compound treatment 1.361801E8 -2.03E7 -0.26 1.33902209E8 -8550000.0 -0.15 -0.2838 -0.9652 3178502 Maybridge4_004319 CC(C)OC(=O)Cc1csc(n1)c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E08 compound treatment 1.4135625E8 -1.52E7 -0.19 1.31143351E8 -1.13E7 -0.19 -0.2713 -1.0 3065298 Maybridge4_004320 C/N=c/1\scc(C)n1\N=C\c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E09 compound treatment 1.42413665E8 -1.41E7 -0.18 1.30919608E8 -1.15E7 -0.2 -0.2646 -0.9985 1516019 Maybridge4_004321 Cc1noc(C)c1c2nc(no2)c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E10 compound treatment 9.7639037E7 -5.89E7 -0.74 1.37052207E8 -5400000.0 -0.09 -0.5876 -0.7894 1538780 Maybridge4_004322 NNC(=O)Cc1csc(n1)c2cccc(c2)n3cccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E11 compound treatment 1.32159269E8 -2.44E7 -0.31 1.23936249E8 -1.85E7 -0.32 -0.4401 -0.9998 1280770 Maybridge4_004323 Cc1oc(cc1C(=O)N2CCC(O)(CC2)c3ccc(Cl)cc3)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E12 compound treatment 1.45179711E8 -1.13E7 -0.14 1.29307371E8 -1.31E7 -0.22 -0.2596 -0.9755 3065299 Maybridge4_004324 Clc1ccc(cc1)S(=O)(=O)Cc2nc(CSc3ccccn3)cs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E13 compound treatment 1.17431244E8 -3.91E7 -0.49 1.44721225E8 2270000.0 0.04 -0.3192 -0.649 1082796 Maybridge4_004325 CC(C)(C)C(=O)CN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E14 compound treatment 1.2341459E8 -3.31E7 -0.42 1.27421829E8 -1.5E7 -0.26 -0.4755 -0.9735 1345163 Maybridge4_004326 Clc1cccc(Cl)c1Cc2nc(NC(=O)NN3CCOCC3)cs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E15 compound treatment 1.50528152E8 -5990000.0 -0.08 1.28949094E8 -1.35E7 -0.23 -0.2165 -0.891 3065350 Maybridge4_004327 FC(F)(F)Oc1ccc(/C=C/C(=O)Nc2ccc3[nH]cc(C#N)c3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E16 compound treatment 1.33677439E8 -2.28E7 -0.29 1.44533093E8 2080000.0 0.04 -0.1773 -0.6143 3178503 Maybridge4_004328 NNC(=O)c1csc(n1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E17 compound treatment 1.42545785E8 -1.4E7 -0.18 1.2930625E8 -1.31E7 -0.22 -0.283 -0.9924 3178504 Maybridge4_004329 CC1=CSC2SC(=C(C)C21)C3=NNC(O)(C3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E18 compound treatment 1.14775278E8 -4.17E7 -0.52 8.9682074E7 -5.28E7 -0.9 -1.0089 -0.9664 3065351 Maybridge4_004330 Cc1nc(COc2cccc(Cl)c2)sc1c3ccnn3C(=O)C=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E19 compound treatment 1.21168192E8 -3.53E7 -0.44 1.13065151E8 -2.94E7 -0.5 -0.6692 -0.998 3178505 Maybridge4_004331 CC(C)(C)c1nc2scc(c3ccc(Cl)cc3)n2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E20 compound treatment 8.2365121E7 -7.41E7 -0.93 7.8952248E7 -6.35E7 -1.09 -1.4263 -0.997 1595891 Maybridge4_004332 Clc1ccc(SC(=O)CCn2c(=O)oc3ccccc23)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E21 compound treatment 1.39565442E8 -1.69E7 -0.21 1.2236732E8 -2.01E7 -0.34 -0.3934 -0.9733 3178506 Maybridge4_004333 NNC(=O)c1nc(no1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E22 compound treatment 1.04936549E8 -5.16E7 -0.65 1.27020544E8 -1.54E7 -0.26 -0.6442 -0.9219 3065354 Maybridge4_004334 Cc1nc(cs1)C(=S)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E23 mock treatment 1.29922109E8 -2.66E7 -0.33 1.14994007E8 -2.75E7 -0.47 -0.5682 -0.9859 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 E24 mock treatment 1.29562008E8 -2.7E7 -0.34 1.11386533E8 -3.11E7 -0.53 -0.6151 -0.9761 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F01 compound treatment 1.38330573E8 -1.82E7 -0.23 1.25605511E8 -1.68E7 -0.29 -0.3652 -0.9933 1669430 Maybridge4_004335 Cc1c(C(=O)Oc2ccc(Cl)cc2)n(C)oc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F02 compound treatment 1.34383345E8 -2.21E7 -0.28 1.22701191E8 -1.97E7 -0.34 -0.4353 -0.9952 1470635 Maybridge4_004336 CCOC(=O)c1cc(on1)c2csc(CS(=O)(=O)C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F03 compound treatment 1.39611384E8 -1.69E7 -0.21 1.21718191E8 -2.07E7 -0.35 -0.4009 -0.9697 3178507 Maybridge4_004337 FC(F)(F)c1ccnc(Oc2ccc(cc2)C3=NCCS3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F04 compound treatment 9.3389364E7 -6.31E7 -0.79 1.2708521E8 -1.54E7 -0.26 -0.7459 -0.8939 3065356 Maybridge4_004338 Cc1n[nH]c(=O)c2nc(sc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F05 compound treatment 1.3194048E8 -2.46E7 -0.31 1.25987444E8 -1.65E7 -0.28 -0.4172 -0.999 3178508 Maybridge4_004339 FC(F)(F)Oc1ccc(cc1)c2noc(NC(=O)NN3CCCCC3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F06 compound treatment 1.1418709E8 -4.23E7 -0.53 1.10256889E8 -3.22E7 -0.55 -0.7651 -0.9998 3178509 Maybridge4_004340 Cc1nc2ccccn2c1c3ccnc(SCC(=O)c4ccc(Cl)cc4)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F07 compound treatment 1.3372471E8 -2.28E7 -0.29 9.1326812E7 -5.11E7 -0.88 -0.8209 -0.8917 3065357 Maybridge4_004341 Cc1nnsc1c2onc(C)c2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F08 compound treatment 1.40881832E8 -1.56E7 -0.2 9.4753244E7 -4.77E7 -0.82 -0.716 -0.8527 3065359 Maybridge4_004342 Cc1nc2ccccn2c1c3ccnn3C(=O)c4ccc(cc4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F09 compound treatment 1.07809366E8 -4.87E7 -0.61 8.9372805E7 -5.31E7 -0.91 -1.0745 -0.9814 1733300 Maybridge4_004343 Sc1nccc(n1)c2csc(COc3ccccc3Cl)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F10 compound treatment 1.29276544E8 -2.72E7 -0.34 8.0887573E7 -6.16E7 -1.05 -0.9867 -0.8907 3178510 Maybridge4_004344 Cc1onc(c1c2csc(Nc3ccccc3Cl)n2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F11 compound treatment 1.6556833E8 9060000.0 0.11 9.9718268E7 -4.27E7 -0.73 -0.4369 -0.5902 3178511 Maybridge4_004345 COC(=O)c1sccc1NC(=O)C2CCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F12 compound treatment 1.41126505E8 -1.54E7 -0.19 1.35918122E8 -6530000.0 -0.11 -0.2155 -0.9663 3065409 Maybridge4_004346 COC(OC)c1c(cnn1C(=O)Nc2ccccc2)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F13 compound treatment 1.39505771E8 -1.7E7 -0.21 1.2295694E8 -1.95E7 -0.33 -0.3868 -0.9767 3178512 Maybridge4_004347 CCOC(=O)c1nn(cc(Sc2nnc(n2C)C(F)(F)F)c1=O)c3ccc(cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F14 compound treatment 9.064897E7 -6.59E7 -0.83 1.24478949E8 -1.8E7 -0.31 -0.8017 -0.9094 3065410 Maybridge4_004348 Cc1cc(no1)c2c(C(=O)Sc3ccccc3)c(C)nn2c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F15 compound treatment 1.38516018E8 -1.8E7 -0.23 9.2196983E7 -5.03E7 -0.86 -0.7679 -0.8634 3178513 Maybridge4_004349 CN(C)C(=O)Oc1nc(nc(C)c1Oc2ccc(Cl)cc2Cl)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F16 compound treatment 1.30093977E8 -2.64E7 -0.33 1.20637148E8 -2.18E7 -0.37 -0.4984 -0.9982 3065413 Maybridge4_004350 Cc1noc2ncnc(SCc3ccc(cc3)C(F)(F)F)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F17 compound treatment 1.15587382E8 -4.09E7 -0.51 1.07616305E8 -3.48E7 -0.6 -0.7846 -0.9972 1122678 Maybridge4_004351 Cn1ccnc1Sc2cnc(SCc3ccc(Cl)cc3)nc2c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F18 compound treatment 8.5278124E7 -7.12E7 -0.89 1.37128757E8 -5320000.0 -0.09 -0.6963 -0.7752 1056664 Maybridge4_004352 NC(=O)COc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F19 compound treatment 1.3438314E8 -2.21E7 -0.28 7.7373761E7 -6.51E7 -1.11 -0.984 -0.8571 3178514 Maybridge4_004353 COC(OC)c1ccc(C#N)c(SCc2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F20 compound treatment 1.4079402E8 -1.57E7 -0.2 7.5569286E7 -6.69E7 -1.14 -0.949 -0.8169 3065416 Maybridge4_004354 Cc1ccc(/N=C/c2c(Sc3ccc(Cl)cc3)nc4sccn24)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F21 compound treatment 1.31289767E8 -2.52E7 -0.32 9.8643414E7 -4.38E7 -0.75 -0.754 -0.9264 3178515 Maybridge4_004355 COc1ccc(C/N=C/c2ccnc(SCc3ccc(Cl)cc3Cl)n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F22 compound treatment 9.0033102E7 -6.65E7 -0.83 7.8063034E7 -6.44E7 -1.1 -1.369 -0.9905 1543403 Maybridge4_004356 CC(C)(C)c1ccc(OCc2ncc(c(N)n2)S(=O)(=O)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F23 mock treatment 8.9620559E7 -6.69E7 -0.84 1.2897756E8 -1.35E7 -0.23 -0.7564 -0.8692 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 F24 mock treatment 1.122862E8 -4.42E7 -0.55 1.16212322E8 -2.62E7 -0.45 -0.7099 -0.9945 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G01 compound treatment 1.65182688E8 8670000.0 0.11 1.68549021E8 2.61E7 0.45 0.3928 0.8543 3065419 Maybridge4_004357 CCOC(=O)c1cc(oc1C(F)(F)F)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G02 compound treatment 1.71237724E8 1.47E7 0.18 1.74108739E8 3.17E7 0.54 0.5138 0.8974 3178592 Maybridge4_004358 NNC(=O)Cc1csc2nc(nn12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G03 compound treatment 1.61893779E8 5380000.0 0.07 1.52808315E8 1.04E7 0.18 0.1731 0.9124 1715416 Maybridge4_004359 CCOC(=O)c1cc(c2ccccc2)n(CCNC(=O)OC(C)(C)C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G04 compound treatment 1.76062917E8 1.95E7 0.25 1.77861704E8 3.54E7 0.61 0.6021 0.9207 3178593 Maybridge4_004360 Cc1n[nH]c(c2cccs2)c1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G05 compound treatment 1.84749298E8 2.82E7 0.35 1.82176896E8 3.97E7 0.68 0.7313 0.9538 1728275 Maybridge4_004361 Cc1ccc(cc1)c2csc(CS(=O)(=O)C(C)(C)C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G06 compound treatment 2.04961025E8 4.84E7 0.61 1.99296866E8 5.68E7 0.97 1.1178 0.9743 3178594 Maybridge4_004362 NNC(=O)c1cc(CSc2ccc(Cl)cc2)on1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G07 compound treatment 1.86562479E8 3.0E7 0.38 1.91897476E8 4.94E7 0.85 0.8651 0.9336 1526465 Maybridge4_004363 CC(C)(C)S(=O)(=O)Cc1nc(cs1)c2cccc(F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G08 compound treatment 1.78373937E8 2.19E7 0.27 1.81785573E8 3.93E7 0.67 0.6701 0.9216 3065422 Maybridge4_004364 Clc1ccc(CSc2ncc([nH]2)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G09 compound treatment 1.87171807E8 3.07E7 0.38 1.89521014E8 4.71E7 0.81 0.8417 0.9427 1241834 Maybridge4_004365 Fc1ccc(CS(=O)(=O)Cc2noc(n2)c3ccno3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G10 compound treatment 1.86634791E8 3.01E7 0.38 1.80870819E8 3.84E7 0.66 0.7323 0.9654 3064623 Maybridge4_004366 Cc1ccc(cc1)C(=O)CSc2nc(n[nH]2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G11 compound treatment 1.81016215E8 2.45E7 0.31 1.7774816E8 3.53E7 0.6 0.6446 0.9509 3178595 Maybridge4_004367 Fc1ccc2[nH]c3CN(CCc3c2c1)S(=O)(=O)c4ccc(s4)c5cc(on5)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G12 compound treatment 1.56501343E8 -11800.0 0.0 1.74252296E8 3.18E7 0.54 0.3849 0.7069 3064626 Maybridge4_004368 CCOC(=O)c1sc(SCC(=O)c2ccc(Cl)cc2Cl)nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G13 compound treatment 1.5997989E8 3470000.0 0.04 1.67519142E8 2.51E7 0.43 0.3342 0.7748 1519116 Maybridge4_004369 CCOC(=O)c1c(C)n(c(c1S(=O)(=O)NCc2ccccc2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G14 compound treatment 1.72620451E8 1.61E7 0.2 1.76263405E8 3.38E7 0.58 0.5522 0.9006 3064627 Maybridge4_004370 N/C(=N\O)/CS(=O)(=O)Cc1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G15 compound treatment 1.61806005E8 5290000.0 0.07 1.73131818E8 3.07E7 0.53 0.4183 0.7902 3178596 Maybridge4_004371 OC1(CC(=NN1)C2(CC3CC4CC(C3)C2)C4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G16 compound treatment 1.7152353E8 1.5E7 0.19 1.66662473E8 2.42E7 0.41 0.4262 0.9363 3064629 Maybridge4_004372 Cc1nc(CSc2nnc([nH]2)C(C)(C)C)cs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G17 compound treatment 1.85274253E8 2.88E7 0.36 1.70512227E8 2.81E7 0.48 0.5948 0.99 3178597 Maybridge4_004373 CN1N=C(CC1(O)C(F)(F)F)c2coc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G18 compound treatment 1.57543963E8 1030000.0 0.01 1.62815226E8 2.04E7 0.35 0.2557 0.7328 1698546 Maybridge4_004374 CC(C)n1c(SCC(=O)O)nc2cc(Cl)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G19 compound treatment 1.70925891E8 1.44E7 0.18 1.647632E8 2.23E7 0.38 0.3979 0.9416 2121946 Maybridge4_004375 FC(F)(F)c1n[nH]c(SCc2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G20 compound treatment 1.20000954E8 -3.65E7 -0.46 1.25053682E8 -1.74E7 -0.3 -0.5344 -0.9783 3064630 Maybridge4_004376 FC(F)(F)c1ccc(SC(=O)CCn2c(=O)oc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G21 compound treatment 1.57312855E8 800000.0 0.01 1.63581726E8 2.11E7 0.36 0.2629 0.7264 3178598 Maybridge4_004377 CSc1nc(nn1C(=O)N(C)C)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G22 compound treatment 1.84540088E8 2.8E7 0.35 1.80745121E8 3.83E7 0.66 0.7122 0.9573 1190557 Maybridge4_004378 Fc1ccc(cc1)n2ccc(=O)c(n2)c3cc[nH]n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G23 mock treatment 1.72259987E8 1.57E7 0.2 1.69176133E8 2.67E7 0.46 0.4632 0.9295 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 G24 mock treatment 1.69008098E8 1.25E7 0.16 1.64366957E8 2.19E7 0.38 0.3761 0.925 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H01 compound treatment 1.88575276E8 3.21E7 0.4 1.92775463E8 5.03E7 0.86 0.8936 0.9399 3178599 Maybridge4_004379 FC(F)(F)c1ccc(Cn2c(=O)oc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H02 compound treatment 1.65633833E8 9120000.0 0.11 1.55316825E8 1.29E7 0.22 0.2367 0.9534 3178600 Maybridge4_004380 FC(F)(F)c1ccc(cc1)c2nc(cs2)C(=O)/C=C/N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H03 compound treatment 1.93808803E8 3.73E7 0.47 1.8959804E8 4.71E7 0.81 0.9015 0.9664 1643215 Maybridge4_004381 Cc1cc(C(=O)NN)n(n1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H04 compound treatment 1.62674219E8 6160000.0 0.08 1.90509715E8 4.81E7 0.82 0.6364 0.7701 3064634 Maybridge4_004382 Cc1nc2c(=O)n(nc(C)c2s1)c3cc(ccc3Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H05 compound treatment 2.00616522E8 4.41E7 0.55 1.94287371E8 5.18E7 0.89 1.0187 0.9741 3178601 Maybridge4_004383 Cc1nc(nc(O)c1Cl)c2ccccc2OC(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H06 compound treatment 1.55275165E8 -1240000.0 -0.02 1.44114046E8 1670000.0 0.03 0.0092 0.2826 3178602 Maybridge4_004384 Cc1nc2ccccn2c1c3ccnc(SCC(=O)c4cccc(c4)C(F)(F)F)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H07 compound treatment 1.97520589E8 4.1E7 0.51 1.89781657E8 4.73E7 0.81 0.9367 0.976 3064670 Maybridge4_004385 CC(C)(C)c1csc(n1)c2ccc(OC(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H08 compound treatment 2.09016846E8 5.25E7 0.66 2.0106119E8 5.86E7 1.0 1.1752 0.9792 1738969 Maybridge4_004386 Cc1nc2ccccn2c1c3ccnn3C(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H09 compound treatment 2.25046106E8 6.85E7 0.86 1.3581082E8 -6640000.0 -0.11 0.5276 0.6084 3064672 Maybridge4_004387 CCOC(=O)c1c(Sc2ccccc2)cnn1C(=O)c3ccc(cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H10 compound treatment 1.46673808E8 -9840000.0 -0.12 1.50485305E8 8040000.0 0.14 0.01 0.0541 3178603 Maybridge4_004388 O=C(c1ccno1)n2nccc2c3cc(no3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H11 compound treatment 1.50735642E8 -5780000.0 -0.07 1.46146978E8 3700000.0 0.06 -0.0065 -0.0674 3064674 Maybridge4_004389 CCOC(=O)c1[nH]ncc1Sc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H12 compound treatment 1.76202887E8 1.97E7 0.25 1.68396142E8 2.59E7 0.44 0.4887 0.9616 3178604 Maybridge4_004390 CCOC(=O)c1cc(nn1C(=O)C)c2ccc(Cl)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H13 compound treatment 1.81487624E8 2.5E7 0.31 1.81483825E8 3.9E7 0.67 0.694 0.9404 1154209 Maybridge4_004391 CCOC(=O)c1nn(cc(Sc2ccc(Cl)cc2)c1=O)c3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H14 compound treatment 2.02852032E8 4.63E7 0.58 2.0943886E8 6.7E7 1.15 1.2219 0.9504 3064675 Maybridge4_004392 Cc1cc(no1)c2nc(cs2)c3ccnn3C(=O)Nc4cccc(Cl)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H15 compound treatment 1.83567533E8 2.71E7 0.34 1.73664898E8 3.12E7 0.53 0.6178 0.976 1612205 Maybridge4_004393 Cc1nc(C)c(Oc2ccc(Cl)cc2Cl)c(n1)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H16 compound treatment 1.78371412E8 2.19E7 0.27 1.9105813E8 4.86E7 0.83 0.7823 0.8929 3064677 Maybridge4_004394 Cc1nc(nc(Sc2ccccc2Cl)c1Oc3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H17 compound treatment 1.78553421E8 2.2E7 0.28 1.74952533E8 3.25E7 0.56 0.5889 0.9479 1277240 Maybridge4_004395 Cn1ccnc1Sc2cnc(SCC(=O)c3ccc(Cl)cc3)nc2c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H18 compound treatment 1.7685384E8 2.03E7 0.26 1.59144877E8 1.67E7 0.29 0.3825 0.9984 3178605 Maybridge4_004396 COC(OC)c1nc(SCC(=O)Nc2ccc(cc2)C(C)C)ncc1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H19 compound treatment 1.85729739E8 2.92E7 0.37 1.14175141E8 -2.83E7 -0.48 -0.0831 -0.1368 1575021 Maybridge4_004397 Cc1onc2c(=O)n(nc(C)c12)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H20 compound treatment 1.98664619E8 4.22E7 0.53 1.25687794E8 -1.68E7 -0.29 0.171 0.2843 1613403 Maybridge4_004398 CCOC(=O)c1cnc(nc1Nc2ccc(C)cc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H21 compound treatment 1.78485467E8 2.2E7 0.28 1.11213051E8 -3.12E7 -0.53 -0.1832 -0.3045 3178606 Maybridge4_004399 COc1ccccc1CC/N=C/c2ccnc(SCc3ccc(Cl)cc3Cl)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H22 compound treatment 1.98815988E8 4.23E7 0.53 1.95693366E8 5.32E7 0.91 1.0197 0.9669 3064678 Maybridge4_004400 FC(F)(F)COc1ccc(cn1)c2nc(cs2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H23 mock treatment 1.79912453E8 2.34E7 0.29 1.74097481E8 3.16E7 0.54 0.5906 0.9586 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 H24 mock treatment 1.70811876E8 1.43E7 0.18 1.57290872E8 1.48E7 0.25 0.3065 0.9855 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I01 compound treatment 1.8254951E8 2.6E7 0.33 1.71886165E8 2.94E7 0.5 0.5873 0.978 1124762 Maybridge4_004401 Cc1oc(cc1COC(=O)Nc2ccccc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I02 compound treatment 2.06562233E8 5.0E7 0.63 1.80432202E8 3.8E7 0.65 0.9037 0.9998 3064679 Maybridge4_004402 Oc1nnc(SCC=C)n1c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I03 compound treatment 2.051351E8 4.86E7 0.61 1.75169265E8 3.27E7 0.56 0.8273 0.9991 3178607 Maybridge4_004403 Cc1ccc(cc1)c2csc(n2)c3ccc(cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I04 compound treatment 2.06856612E8 5.03E7 0.63 1.83912919E8 4.15E7 0.71 0.9485 0.9983 3178608 Maybridge4_004404 O=C(Oc1ccc2ccccc2c1C3SCCS3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I05 compound treatment 2.21737807E8 6.52E7 0.82 1.92674068E8 5.02E7 0.86 1.1865 0.9997 3064680 Maybridge4_004405 Fc1cccc(c1)c2csc(COc3ccccc3Cl)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I06 compound treatment 2.17041763E8 6.05E7 0.76 1.85731979E8 4.33E7 0.74 1.0608 0.9999 3064719 Maybridge4_004406 CCOC(=O)c1cc(COc2c(Cl)cccc2Cl)on1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I07 compound treatment 2.06866789E8 5.04E7 0.63 1.90524762E8 4.81E7 0.82 1.0286 0.9915 1539274 Maybridge4_004407 COc1ccc(cc1OC)c2nc(CS(=O)(=O)c3ccc(F)cc3)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I08 compound treatment 2.29806991E8 7.33E7 0.92 2.07241371E8 6.48E7 1.11 1.4344 0.9957 3064721 Maybridge4_004408 COC(=O)c1c(C)n[nH]c1c2snnc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I09 compound treatment 2.06021657E8 4.95E7 0.62 1.95734261E8 5.33E7 0.91 1.0841 0.9825 3178609 Maybridge4_004409 Cc1c(cc(c2ccccc2)n1CCSCc3c(F)cccc3Cl)C(=O)NCc4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I10 compound treatment 1.94430883E8 3.79E7 0.48 1.8584226E8 4.34E7 0.74 0.8616 0.9768 3064722 Maybridge4_004410 FC(F)(F)c1ccccc1c2ncc(o2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I11 compound treatment 2.26584262E8 7.01E7 0.88 1.9155113E8 4.91E7 0.84 1.2159 0.9997 3178610 Maybridge4_004411 COC(=O)C1SCCN1S(=O)(=O)c2ccc(s2)c3cc(on3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I12 compound treatment 2.03809173E8 4.73E7 0.59 1.86942457E8 4.45E7 0.76 0.9581 0.9924 3064724 Maybridge4_004412 CCOC(=O)c1sc(COc2ccc(cc2)C3SCCS3)nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I13 compound treatment 1.98023682E8 4.15E7 0.52 1.74871051E8 3.24E7 0.56 0.7607 0.9995 3178611 Maybridge4_004413 CCOC(=O)c1c(C)oc(c1S(=O)(=O)NCc2ccccc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I14 compound treatment 1.96184078E8 3.97E7 0.5 1.93139418E8 5.07E7 0.87 0.9655 0.9652 1359873 Maybridge4_004414 CCOC(=O)c1sc(COc2ccc(cc2)C(C)(C)C)nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I15 compound treatment 2.14801236E8 5.83E7 0.73 1.96127607E8 5.37E7 0.92 1.1668 0.9936 1719811 Maybridge4_004415 COC(=O)c1cc(oc1C)S(=O)(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I16 compound treatment 2.27040189E8 7.05E7 0.88 1.80645861E8 3.82E7 0.65 1.0879 0.9889 3064726 Maybridge4_004416 Fc1ccc(NC(=O)Nc2csc(n2)c3cccs3)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I17 compound treatment 2.1280526E8 5.63E7 0.71 1.92908913E8 5.05E7 0.86 1.1101 0.995 3178696 Maybridge4_004417 CCOC(=O)c1cc(C)nc(Sc2ccccn2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I18 compound treatment 1.9852203E8 4.2E7 0.53 1.80521079E8 3.81E7 0.65 0.8335 0.9944 1015446 Maybridge4_004418 NNS(=O)(=O)c1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I19 compound treatment 2.12585292E8 5.61E7 0.7 1.70399002E8 2.8E7 0.48 0.8357 0.9824 3178697 Maybridge4_004419 CSc1nnc(c2ccc(cc2)C(C)(C)C)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I20 compound treatment 2.12599035E8 5.61E7 0.7 1.87959451E8 4.55E7 0.78 1.0484 0.9987 3064729 Maybridge4_004420 CC(C)n1c(SCC(=O)c2ccc(C)cc2)nc3cc(ccc13)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I21 compound treatment 2.20773488E8 6.43E7 0.81 1.7790752E8 3.55E7 0.61 0.9992 0.9902 3178698 Maybridge4_004421 CSc1n[nH]c(=O)n1C2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I22 compound treatment 2.26285504E8 6.98E7 0.88 1.65260557E8 2.28E7 0.39 0.895 0.9339 1629116 Maybridge4_004422 Fc1ccc(cc1)n2ccc(=O)c(n2)c3ccnc(S)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I23 mock treatment 2.27031848E8 7.05E7 0.88 1.67290376E8 2.48E7 0.43 0.9262 0.9436 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 I24 mock treatment 1.9052328E8 3.4E7 0.43 1.58679373E8 1.62E7 0.28 0.4981 0.9784 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J01 compound treatment 2.06580929E8 5.01E7 0.63 1.70688309E8 2.82E7 0.48 0.7859 0.9916 3064730 Maybridge4_004423 Cc1cc(C)c(C#N)c(SCc2nc(no2)c3ccc(OC(F)(F)F)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J02 compound treatment 1.98354399E8 4.18E7 0.52 1.86106504E8 4.37E7 0.75 0.8996 0.9851 3178699 Maybridge4_004424 COC(=O)c1noc(C)c1C(=O)/C=C/N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J03 compound treatment 1.98460596E8 4.19E7 0.53 2.01828075E8 5.94E7 1.02 1.0908 0.953 1578491 Maybridge4_004425 CC(C)(C)c1cc(no1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J04 compound treatment 1.32381139E8 -2.41E7 -0.3 1.67916247E8 2.55E7 0.44 0.0942 0.1775 1270914 Maybridge4_004426 Cc1cc(no1)c2nc(cs2)C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J05 compound treatment 1.56111169E8 -402000.0 -0.01 1.36700774E8 -5750000.0 -0.1 -0.0731 -0.7424 1517245 Maybridge4_004427 CN(C)C(=O)c1noc(C)c1c2cc[nH]c(=S)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J06 compound treatment 1.71904683E8 1.54E7 0.19 1.61391928E8 1.89E7 0.32 0.3658 0.9693 1241417 Maybridge4_004428 CC(C)c1ccc(NC(=O)CSc2nccc(n2)c3c(C)nc4ccccn34)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J07 compound treatment 1.89456259E8 3.29E7 0.41 1.64272805E8 2.18E7 0.37 0.5564 0.9987 3064781 Maybridge4_004429 FC(F)(F)Oc1ccccc1c2nnc(o2)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J08 compound treatment 2.17059145E8 6.05E7 0.76 1.65299942E8 2.29E7 0.39 0.8137 0.9524 1319855 Maybridge4_004430 Cc1nc2ccccn2c1c3ccnn3C(=O)c4ccno4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J09 compound treatment 2.10948139E8 5.44E7 0.68 1.70555061E8 2.81E7 0.48 0.8231 0.9853 3178700 Maybridge4_004431 Clc1ccccc1OCc2nc(cs2)c3ccnc(SCC(=O)c4ccccc4)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J10 compound treatment 2.13028303E8 5.65E7 0.71 1.4571061E8 3260000.0 0.06 0.5408 0.7604 3178701 Maybridge4_004432 FC(F)(F)c1ccc(cc1)S(=O)(=O)n2nccc2c3cc(no3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J11 compound treatment 2.10151382E8 5.36E7 0.67 1.41177723E8 -1270000.0 -0.02 0.4604 0.6839 3064782 Maybridge4_004433 FC(F)(F)c1cccnc1SCc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J12 compound treatment 1.73765316E8 1.73E7 0.22 1.60236535E8 1.78E7 0.3 0.3683 0.986 1133437 Maybridge4_004434 COC(OC)c1nc2sc(C(=O)OC)c(N)c2cc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J13 compound treatment 1.72227713E8 1.57E7 0.2 1.64804574E8 2.24E7 0.38 0.41 0.9524 3178702 Maybridge4_004435 CN(C)/C=C(\Sc1ccc(cn1)C(F)(F)F)/C(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J14 compound treatment 1.95955534E8 3.94E7 0.49 1.20593678E8 -2.19E7 -0.37 0.0853 0.1376 3178703 Maybridge4_004436 Cc1cc(no1)c2nc(cs2)c3ccnn3S(=O)(=O)c4cccc(c4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J15 compound treatment 2.03843845E8 4.73E7 0.59 1.50988613E8 8540000.0 0.15 0.5232 0.8556 3064785 Maybridge4_004437 Cc1nc(C)c(Oc2ccc(Cl)cc2Cl)c(O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J16 compound treatment 2.10992725E8 5.45E7 0.68 1.7770754E8 3.53E7 0.6 0.91 0.9981 3064786 Maybridge4_004438 COC(=O)c1c(C)nn(c1c2snnc2C)c3ccc(OC(F)(F)F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J17 compound treatment 2.05881822E8 4.94E7 0.62 1.41388921E8 -1060000.0 -0.02 0.4251 0.6861 3178704 Maybridge4_004439 Cc1cc(no1)c2noc(n2)c3cc(C)on3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J18 compound treatment 2.01381348E8 4.49E7 0.56 1.75138123E8 3.27E7 0.56 0.7937 1.0 3064787 Maybridge4_004440 CSc1[nH]c(=O)[nH]c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J19 compound treatment 2.05608174E8 4.91E7 0.62 1.86435171E8 4.4E7 0.75 0.9679 0.995 3178705 Maybridge4_004441 O/N=C/c1ccnc(SCc2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J20 compound treatment 2.0256459E8 4.61E7 0.58 1.71686785E8 2.92E7 0.5 0.7624 0.9974 1443040 Maybridge4_004442 CCOC(=O)c1cnc(nc1Nc2ccc(Cl)cc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J21 compound treatment 1.75778801E8 1.93E7 0.24 1.61239249E8 1.88E7 0.32 0.3983 0.9901 1496600 Maybridge4_004443 CN(C)C(=O)Oc1nc(NC(=O)C)nc(C)c1Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J22 compound treatment 2.01092747E8 4.46E7 0.56 1.5730566E8 1.49E7 0.25 0.5753 0.9364 1705322 Maybridge4_004444 Cc1nc(COc2ccc(cc2)C(C)(C)C)ncc1S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J23 mock treatment 2.00367016E8 4.39E7 0.55 1.52614608E8 1.02E7 0.17 0.512 0.8874 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 J24 mock treatment 1.97969124E8 4.15E7 0.52 1.76029616E8 3.36E7 0.57 0.7742 0.9988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K01 compound treatment 1.50928258E8 -5580000.0 -0.07 1.44308624E8 1860000.0 0.03 -0.027 -0.3512 3064790 Maybridge4_004445 FC(F)(F)c1oc(cc1COC(=O)Nc2ccccc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K02 compound treatment 1.58186742E8 1670000.0 0.02 1.4240733E8 -41600.0 0.0 0.0143 0.6828 3178706 Maybridge4_004446 CSc1nnc(c2ccc(cc2)C(C)(C)C)n1Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K03 compound treatment 1.64793134E8 8280000.0 0.1 1.56132836E8 1.37E7 0.23 0.2391 0.933 3064791 Maybridge4_004447 FC(F)(F)c1ccc(cc1)c2nc(cs2)c3ccc(C#N)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K04 compound treatment 1.68748283E8 1.22E7 0.15 1.39912591E8 -2540000.0 -0.04 0.0778 0.4879 3065620 Maybridge4_004448 CC(C)(C)c1nnc(SCc2nc(no2)c3cccc(c3)n4cccc4)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K05 compound treatment 1.65933865E8 9420000.0 0.12 1.56503132E8 1.41E7 0.24 0.2537 0.9464 3065621 Maybridge4_004449 FC(F)(F)c1ccc(cc1)c2csc(CS(=O)(=O)Cc3cccc(c3)C(F)(F)F)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K06 compound treatment 1.97989631E8 4.15E7 0.52 1.81018706E8 3.86E7 0.66 0.8348 0.993 3065622 Maybridge4_004450 NNC(=O)c1cc(COc2c(Cl)cccc2Cl)on1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K07 compound treatment 1.69858408E8 1.33E7 0.17 1.56709704E8 1.43E7 0.24 0.291 0.9831 1292280 Maybridge4_004451 CC1(C)CCC(C)(C)c2cc(ccc21)c3csc(CC#N)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K08 compound treatment 1.72604718E8 1.61E7 0.2 1.584096E8 1.6E7 0.27 0.3359 0.9889 3065623 Maybridge4_004452 COC(=O)c1c(C)nn(C(=O)c2cccs2)c1c3snnc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K09 compound treatment 2.03001275E8 4.65E7 0.58 1.63492884E8 2.1E7 0.36 0.6671 0.9732 3065624 Maybridge4_004453 Cc1ccc(NC(=O)c2cc3cc(OC(F)(F)F)ccc3[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K10 compound treatment 1.85966645E8 2.95E7 0.37 1.62708861E8 2.03E7 0.35 0.5065 0.9995 3065625 Maybridge4_004454 Clc1cc(Cl)cc(OCc2nn[nH]n2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K11 compound treatment 1.82046646E8 2.55E7 0.32 1.80363696E8 3.79E7 0.65 0.6854 0.947 3178707 Maybridge4_004455 CC1(C)C(NS(=O)(=O)c2ccc(s2)c3cc(on3)C(F)(F)F)[C@@]4(C)CCC1C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K12 compound treatment 2.11468507E8 5.5E7 0.69 1.72210357E8 2.98E7 0.51 0.8477 0.9889 3065626 Maybridge4_004456 Oc1nnc(S)n1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K13 compound treatment 1.7720509E8 2.07E7 0.26 1.11804341E8 -3.06E7 -0.52 -0.1874 -0.3202 1404401 Maybridge4_004457 Cc1cc(C)c2cc([nH]c2c1)C(=O)Nc3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K14 compound treatment 1.62345122E8 5830000.0 0.07 1.51890685E8 9440000.0 0.16 0.166 0.9358 1365668 Maybridge4_004458 Cc1nc(COc2ccc(cc2)C(C)(C)C)sc1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K15 compound treatment 1.27497498E8 -2.9E7 -0.36 1.4448294E8 2030000.0 0.03 -0.2328 -0.6366 3065627 Maybridge4_004459 Cc1c(sc2ccccc12)C3=NNC(O)(C3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K16 compound treatment 2.1375974E8 5.72E7 0.72 1.85089613E8 4.26E7 0.73 1.0239 1.0 1324032 Maybridge4_004460 NC(=S)CS(=O)(=O)c1ccccn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K17 compound treatment 2.06141927E8 4.96E7 0.62 1.76861136E8 3.44E7 0.59 0.8568 0.9996 1539758 Maybridge4_004461 CN(C)C(=O)Nc1c(C)onc1c2c(Cl)cccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K18 compound treatment 1.81092783E8 2.46E7 0.31 1.54422957E8 1.2E7 0.2 0.363 0.9803 3065628 Maybridge4_004462 CCOC(=O)CSc1nc2cc(Cl)c(Cl)cc2n1CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K19 compound treatment 1.29912134E8 -2.66E7 -0.33 1.70387551E8 2.79E7 0.48 0.1022 0.1753 1230780 Maybridge4_004463 Cc1cc(NC(=O)NN2CCOCC2)nn1c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K20 compound treatment 1.58415936E8 1900000.0 0.02 1.54514804E8 1.21E7 0.21 0.1629 0.7836 3065629 Maybridge4_004464 CCOC(=O)c1sc(nc1OC(=O)c2ccc(cc2)C(F)(F)F)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K21 compound treatment 1.98543726E8 4.2E7 0.53 1.68866831E8 2.64E7 0.45 0.6926 0.9971 3178708 Maybridge4_004465 Clc1cccc(c1)n2c(SCC=C)n[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K22 compound treatment 1.92489372E8 3.6E7 0.45 1.84119027E8 4.17E7 0.71 0.8235 0.9756 3065630 Maybridge4_004466 NNC(=O)Cc1cc(Br)sc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K23 mock treatment 1.78943894E8 2.24E7 0.28 1.65640679E8 2.32E7 0.4 0.4797 0.9858 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 K24 mock treatment 1.80674708E8 2.42E7 0.3 1.50568948E8 8120000.0 0.14 0.3126 0.9375 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L01 compound treatment 1.65990355E8 9480000.0 0.12 1.52097018E8 9650000.0 0.17 0.2008 0.987 3178709 Maybridge4_004467 CC(C)(C)c1cc(C(=O)Oc2ccc(Cl)cc2)n(Cc3ccccc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L02 compound treatment 1.06510488E8 -5.0E7 -0.63 1.05083347E8 -3.74E7 -0.64 -0.8958 -1.0 3065631 Maybridge4_004468 CCOC(=O)c1cc(on1)C(=O)/C=C/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L03 compound treatment 1.2432305E8 -3.22E7 -0.4 1.31889803E8 -1.06E7 -0.18 -0.4133 -0.9343 3178710 Maybridge4_004469 Cc1cc(no1)c2nnc(o2)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L04 compound treatment 9.4788418E7 -6.17E7 -0.77 1.01179556E8 -4.13E7 -0.71 -1.0471 -0.999 3178711 Maybridge4_004470 CCOC(=O)c1nc(C)sc1c2ccnn2S(=O)(=O)c3ccccc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L05 compound treatment 1.22553365E8 -3.4E7 -0.43 9.8978126E7 -4.35E7 -0.74 -0.8274 -0.965 1698871 Maybridge4_004471 O=C(Nc1ccno1)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L06 compound treatment 1.85646381E8 2.91E7 0.37 1.64820545E8 2.24E7 0.38 0.5292 0.9997 3065632 Maybridge4_004472 COC(Cn1c(S)nnc1c2ccccc2)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L07 compound treatment 1.67744385E8 1.12E7 0.14 1.51761984E8 9310000.0 0.16 0.2124 0.9981 3178712 Maybridge4_004473 FC(F)(F)Oc1ccc(cc1)c2nnc(o2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L08 compound treatment 1.69585667E8 1.31E7 0.16 1.40621617E8 -1830000.0 -0.03 0.0938 0.5621 3178713 Maybridge4_004474 COC(Cn1c(SCC(=O)c2cccc(c2)C(F)(F)F)nnc1c3ccc(Cl)cc3)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L09 compound treatment 1.63916005E8 7400000.0 0.09 1.03979812E8 -3.85E7 -0.66 -0.4 -0.6014 3065633 Maybridge4_004475 CCOC(=O)c1c(Sc2ccccc2)cnn1C(=O)Nc3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L10 compound treatment 1.3882798E8 -1.77E7 -0.22 1.18111026E8 -2.43E7 -0.42 -0.4515 -0.9565 3178714 Maybridge4_004476 COC(Cn1c(SCC(=O)Nc2cc(Cl)cc(Cl)c2)nnc1c3ccccc3)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L11 compound treatment 1.86523497E8 3.0E7 0.38 1.54413047E8 1.2E7 0.2 0.411 0.9591 3065634 Maybridge4_004477 Cc1ccc(CSc2ncccc2C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L12 compound treatment 9.5736346E7 -6.08E7 -0.76 1.59317117E8 1.69E7 0.29 -0.3349 -0.4108 3065635 Maybridge4_004478 CSc1nccc(n1)c2c(C)onc2c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L13 compound treatment 1.07419719E8 -4.91E7 -0.62 9.3954974E7 -4.85E7 -0.83 -1.0225 -0.9892 1231547 Maybridge4_004479 Cc1nccc(n1)c2nn(ccc2=O)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L14 compound treatment 2.14260995E8 5.77E7 0.72 9.9979482E7 -4.25E7 -0.73 -0.0018 -0.0018 3178715 Maybridge4_004480 Cc1cc(no1)c2nc(C)c(s2)c3nnc(SCC(=O)Nc4ccccc4)n3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L15 compound treatment 1.66292636E8 9780000.0 0.12 9.6445465E7 -4.6E7 -0.79 -0.4701 -0.5898 1650913 Maybridge4_004481 CN(C)C(=O)Oc1nc(C)nc(C)c1Oc2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L16 compound treatment 1.02977486E8 -5.35E7 -0.67 9.8074818E7 -4.44E7 -0.76 -1.012 -0.9981 3178716 Maybridge4_004482 Cc1c(sc2nc(nn12)c3ccc(Cl)cc3)C(=O)Oc4ccc(C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L17 compound treatment 1.73521842E8 1.7E7 0.21 9.1312411E7 -5.11E7 -0.88 -0.4681 -0.5195 3065636 Maybridge4_004483 Cc1cc(no1)c2noc(n2)c3snnc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L18 compound treatment 1.80376945E8 2.39E7 0.3 9.032351E7 -5.21E7 -0.89 -0.4193 -0.4455 1687470 Maybridge4_004484 O=c1[nH]c(Nc2ccccc2)c(C#N)c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L19 compound treatment 1.73123149E8 1.66E7 0.21 1.43248822E8 800000.0 0.01 0.157 0.752 3178791 Maybridge4_004485 COC(OC)c1ccc(C#N)c(SCc2ccc(C)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L20 compound treatment 1.33426214E8 -2.31E7 -0.29 1.0005319E8 -4.24E7 -0.73 -0.718 -0.9188 1451924 Maybridge4_004486 CSc1nc(COc2ccc(cc2)C(C)(C)C)nc(N)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L21 compound treatment 1.72217957E8 1.57E7 0.2 1.60289636E8 1.78E7 0.31 0.3553 0.9775 3065637 Maybridge4_004487 FC(F)(F)c1cnc(S)c(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L22 compound treatment 1.14981032E8 -4.15E7 -0.52 9.2535703E7 -4.99E7 -0.85 -0.9726 -0.9719 3178792 Maybridge4_004488 CCOC(=O)CSc1nc2sccn2c1/C=N/c3cc(Cl)cc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L23 mock treatment 1.62138845E8 5630000.0 0.07 9.3677465E7 -4.88E7 -0.83 -0.5404 -0.645 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 L24 mock treatment 1.66026062E8 9510000.0 0.12 1.56889109E8 1.44E7 0.25 0.2592 0.9442 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M01 compound treatment 1.03890937E8 -5.26E7 -0.66 1.02475153E8 -4.0E7 -0.68 -0.9506 -0.9998 3065638 Maybridge4_004489 Cc1oc(cc1C(=O)C(=C2SCCS2)C#N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M02 compound treatment 1.28338059E8 -2.82E7 -0.35 1.21530363E8 -2.09E7 -0.36 -0.5031 -1.0 3065639 Maybridge4_004490 Nc1nnc(SCc2nc(no2)c3ccccc3)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M03 compound treatment 1.28978329E8 -2.75E7 -0.35 1.23261312E8 -1.92E7 -0.33 -0.4765 -0.9997 1454547 Maybridge4_004491 C1COc2ccc(cc2OC1)c3csc(n3)c4ccc(cc4)c5csnn5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M04 compound treatment 1.30128707E8 -2.64E7 -0.33 1.24511471E8 -1.79E7 -0.31 -0.4512 -0.9993 3178793 Maybridge4_004492 CCN(CC)C(=O)Oc1nnc(SC(C)C)n1c2ccc(Cl)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M05 compound treatment 1.40633966E8 -1.59E7 -0.2 1.3468375E8 -7770000.0 -0.13 -0.2348 -0.9807 1188621 Maybridge4_004493 CC(C)(C)c1cc(cc(c1O)C(C)(C)C)c2csc(n2)c3ccno3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M06 compound treatment 1.39200197E8 -1.73E7 -0.22 1.29394602E8 -1.31E7 -0.22 -0.3116 -0.9999 3178794 Maybridge4_004494 Clc1ccccc1C(=O)Oc2ccc(cc2)C3=NCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M07 compound treatment 1.40451162E8 -1.61E7 -0.2 1.3652584E8 -5920000.0 -0.1 -0.2142 -0.9495 3065640 Maybridge4_004495 Cc1ccc(cc1)c2noc(n2)c3cc(nn3Cc4ccccc4)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M08 compound treatment 1.46826002E8 -9690000.0 -0.12 1.34728897E8 -7720000.0 -0.13 -0.1794 -0.9991 3178795 Maybridge4_004496 COCc1cc(OC(=O)N(C)C)nc(COc2ccc(Cl)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M09 compound treatment 1.16532541E8 -4.0E7 -0.5 1.07702904E8 -3.47E7 -0.59 -0.7752 -0.9964 1583006 Maybridge4_004497 Cc1c(cc(c2ccccc2)n1CCCN3CCOCC3)C(=O)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M10 compound treatment 1.47534267E8 -8980000.0 -0.11 1.29551549E8 -1.29E7 -0.22 -0.2358 -0.9512 3065641 Maybridge4_004498 FC(F)(F)c1ccccc1C(=O)NC(=O)NN2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M11 compound treatment 1.3438432E8 -2.21E7 -0.28 1.24984398E8 -1.75E7 -0.3 -0.4077 -0.9993 1136828 Maybridge4_004499 CSc1c(C#N)c(nn1c2ccccc2)c3cc(oc3C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M12 compound treatment 1.29847752E8 -2.67E7 -0.33 1.23792284E8 -1.87E7 -0.32 -0.4624 -0.9997 3065642 Maybridge4_004500 NNC(=O)c1cccc(COc2ccc(cc2)C3SCCS3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M13 compound treatment 1.56675206E8 162000.0 0.0 1.35718742E8 -6730000.0 -0.12 -0.08 -0.6945 1241045 Maybridge4_004501 COc1ccc2[nH]c(cc2c1)C(=O)N(C)c3ccc(F)cc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M14 compound treatment 1.43937996E8 -1.26E7 -0.16 1.3779728E8 -4650000.0 -0.08 -0.1678 -0.9499 1234233 Maybridge4_004502 COc1ccc(OC(=O)c2csc(Cc3c(Cl)cccc3Cl)n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M15 compound treatment 1.39717317E8 -1.68E7 -0.21 1.30689335E8 -1.18E7 -0.2 -0.2913 -0.9997 3178796 Maybridge4_004503 CSc1sc(C2=NNC(O)(C2)C(F)(F)F)c3c1C(=O)CCC3(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M16 compound treatment 1.53334549E8 -3180000.0 -0.04 1.32625248E8 -9820000.0 -0.17 -0.1471 -0.8512 3065643 Maybridge4_004504 Cc1nc(CS(=O)(=O)c2ccccn2)sc1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M17 compound treatment 1.43010998E8 -1.35E7 -0.17 1.27806661E8 -1.46E7 -0.25 -0.297 -0.9818 1507802 Maybridge4_004505 CN(C(=O)N1CCCCC1)c2c(C)onc2c3c(Cl)cccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M18 compound treatment 1.09395414E8 -4.71E7 -0.59 9.7216104E7 -4.52E7 -0.77 -0.9655 -0.9911 3178797 Maybridge4_004506 CN(C)/C=C/C(=O)c1sc(COc2ccccc2Cl)nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M19 compound treatment 1.38399412E8 -1.81E7 -0.23 1.24597693E8 -1.79E7 -0.31 -0.3767 -0.9894 3065644 Maybridge4_004507 Oc1cc(nc(Cc2c(Cl)cccc2Cl)n1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M20 compound treatment 1.27592108E8 -2.89E7 -0.36 1.20534021E8 -2.19E7 -0.38 -0.5218 -0.9999 3178798 Maybridge4_004508 CC(C)n1c(SCC(=O)C(C)(C)C)nc2cc(ccc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M21 compound treatment 1.45769871E8 -1.07E7 -0.13 1.38395721E8 -4050000.0 -0.07 -0.1444 -0.9523 3065645 Maybridge4_004509 Oc1nnc(S)n1c2ccccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M22 compound treatment 1.45634256E8 -1.09E7 -0.14 1.36834178E8 -5610000.0 -0.1 -0.1645 -0.9853 3178799 Maybridge4_004510 Cc1cc(C)c(C#N)c(SCc2nc(COc3cccc(c3)C(F)(F)F)no2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M23 mock treatment 1.51648549E8 -4860000.0 -0.06 1.34834982E8 -7610000.0 -0.13 -0.1353 -0.9402 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 M24 mock treatment 1.45447986E8 -1.11E7 -0.14 1.30168177E8 -1.23E7 -0.21 -0.2468 -0.9797 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N01 compound treatment 1.38166511E8 -1.83E7 -0.23 1.26226588E8 -1.62E7 -0.28 -0.3591 -0.9956 3065646 Maybridge4_004511 CC(C)(C)c1cc(C(=O)Oc2cccc(c2)C(F)(F)F)n(Cc3ccccc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N02 compound treatment 1.27157618E8 -2.94E7 -0.37 1.25463838E8 -1.7E7 -0.29 -0.466 -0.9932 1256051 Maybridge4_004512 CCOC(=O)c1nc(sc1c2ccnn2C(=O)NC(C)C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N03 compound treatment 1.37552434E8 -1.9E7 -0.24 1.32584862E8 -9860000.0 -0.17 -0.2876 -0.9859 3065647 Maybridge4_004513 Cc1nn(c(C(=O)Sc2cccc(c2)C(F)(F)F)c1Br)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N04 compound treatment 1.07656997E8 -4.89E7 -0.61 1.11566188E8 -3.09E7 -0.53 -0.8072 -0.9973 3178800 Maybridge4_004514 CCOC(=O)c1nc(C)sc1c2ccnn2S(=O)(=O)c3ccc(Cl)cc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N05 compound treatment 1.43364646E8 -1.31E7 -0.16 1.24348757E8 -1.81E7 -0.31 -0.3357 -0.9565 1543758 Maybridge4_004515 O=C(NN1CCOCC1)Nc2ccno2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N06 compound treatment 1.39012407E8 -1.75E7 -0.22 1.25328823E8 -1.71E7 -0.29 -0.3625 -0.9899 3178801 Maybridge4_004516 COC(Cn1c(SCc2ccc(Cl)cc2)nnc1c3ccccc3)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N07 compound treatment 1.36831122E8 -1.97E7 -0.25 1.30055561E8 -1.24E7 -0.21 -0.3246 -0.9971 3065648 Maybridge4_004517 Cc1ccc(SC(=O)c2ccc(OC(F)(F)F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N08 compound treatment 1.3336777E8 -2.31E7 -0.29 6.6021837E7 -7.64E7 -1.31 -1.1304 -0.8435 3178802 Maybridge4_004518 CN(C)/C=C/C(=O)c1c(C)onc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N09 compound treatment 1.26760646E8 -2.98E7 -0.37 8.2488261E7 -6.0E7 -1.03 -0.9897 -0.9062 3065649 Maybridge4_004519 COC(=O)c1noc(C)c1C(=O)/C=C/N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N10 compound treatment 1.46065811E8 -1.04E7 -0.13 1.16747478E8 -2.57E7 -0.44 -0.4038 -0.8796 3178803 Maybridge4_004520 COC(OC)c1c(cnn1c2ccccc2)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N11 compound treatment 1.32778689E8 -2.37E7 -0.3 1.25381976E8 -1.71E7 -0.29 -0.4171 -1.0 3178804 Maybridge4_004521 CCOC(=O)c1cc(CSc2nnc(O)n2c3ccccc3)nn1C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N12 compound treatment 1.3674473E8 -1.98E7 -0.25 8.919848E7 -5.33E7 -0.91 -0.8199 -0.8679 3065650 Maybridge4_004522 CCOC(Cc1nnc(S)n1C)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N13 compound treatment 1.27302783E8 -2.92E7 -0.37 7.4506575E7 -6.79E7 -1.16 -1.0815 -0.8869 1195492 Maybridge4_004523 CC(C)(C)c1nccc(n1)c2nn(ccc2=O)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N14 compound treatment 1.60351413E8 3840000.0 0.05 8.7110325E7 -5.53E7 -0.95 -0.6358 -0.6703 1316271 Maybridge4_004524 Clc1ccc(cc1)c2c(cnn2S(=O)(=O)c3ccccc3)S(=O)(=O)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N15 compound treatment 1.2877695E8 -2.77E7 -0.35 1.20537176E8 -2.19E7 -0.38 -0.5113 -0.9993 3065651 Maybridge4_004525 CN(C)/C=C(/Sc1ccc(C)cc1)\C(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N16 compound treatment 1.32947997E8 -2.36E7 -0.3 1.25741383E8 -1.67E7 -0.29 -0.4113 -0.9999 3178805 Maybridge4_004526 Cc1c(NC(=O)Nc2ccccc2)sc3nc(nn13)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N17 compound treatment 6.9266306E7 -8.72E7 -1.09 1.19700193E8 -2.27E7 -0.39 -1.0493 -0.9032 3065652 Maybridge4_004527 COCc1nc(S)c(C#N)cc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N18 compound treatment 8.4824083E7 -7.17E7 -0.9 1.31264615E8 -1.12E7 -0.19 -0.7713 -0.8388 3065697 Maybridge4_004528 NC(=S)c1cnccc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N19 compound treatment 1.35792982E8 -2.07E7 -0.26 1.26553642E8 -1.59E7 -0.27 -0.3762 -0.9997 3065698 Maybridge4_004529 COC(OC)c1ccc(C#N)c(SCC(=O)c2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N20 compound treatment 1.56510571E8 -2610.0 0.0 9.0693498E7 -5.18E7 -0.89 -0.6265 -0.7071 3065699 Maybridge4_004530 COc1ccc(cc1)c2nc(COc3ccccc3Cl)nc(SC)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N21 compound treatment 1.52014779E8 -4500000.0 -0.06 1.339864E8 -8460000.0 -0.14 -0.1423 -0.9155 1685558 Maybridge4_004531 CCOC(=O)c1cc(on1)c2csc(Nc3ccccc3Cl)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N22 compound treatment 1.33943914E8 -2.26E7 -0.28 1.15985176E8 -2.65E7 -0.45 -0.5205 -0.9744 3065700 Maybridge4_004532 CSc1nnc(c2ccc(Cl)cc2Cl)n1Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N23 mock treatment 6.8491017E7 -8.8E7 -1.1 1.11721108E8 -3.07E7 -0.53 -1.1527 -0.9425 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 N24 mock treatment 1.52955925E8 -3560000.0 -0.04 1.35427523E8 -7020000.0 -0.12 -0.1165 -0.909 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O01 compound treatment 1.21279189E8 -3.52E7 -0.44 1.23837119E8 -1.86E7 -0.32 -0.5378 -0.9871 3065702 Maybridge4_004533 FC(F)(F)Oc1ccccc1NC(=S)NCc2ccc3OCCc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O02 compound treatment 1.22886077E8 -3.36E7 -0.42 1.24221072E8 -1.82E7 -0.31 -0.5189 -0.989 3065703 Maybridge4_004534 CC(C)Sc1nnc(O)n1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O03 compound treatment 1.17968376E8 -3.85E7 -0.48 1.23595396E8 -1.89E7 -0.32 -0.5701 -0.9807 3065704 Maybridge4_004535 FC(F)(F)c1ccc(cc1)c2csc(n2)c3ccc(cc3)c4csnn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O04 compound treatment 1.24242073E8 -3.23E7 -0.4 1.22776766E8 -1.97E7 -0.34 -0.5244 -0.9958 1506889 Maybridge4_004536 Clc1ccc(CSCc2cc(=O)[nH]c(=O)[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O05 compound treatment 1.26352755E8 -3.02E7 -0.38 1.27096925E8 -1.54E7 -0.26 -0.4534 -0.9841 3178806 Maybridge4_004537 FC(F)(F)Oc1ccc(cc1)c2nc(CS(=O)(=O)Cc3ccco3)no2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O06 compound treatment 1.36543676E8 -2.0E7 -0.25 1.40884035E8 -1560000.0 -0.03 -0.1961 -0.7783 3065705 Maybridge4_004538 FC(F)(F)c1ccc(cc1)c2nnc(SCC=C)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O07 compound treatment 1.26810621E8 -2.97E7 -0.37 1.41754464E8 -694000.0 -0.01 -0.2719 -0.7293 3178807 Maybridge4_004539 Fc1ccc(c2nc(no2)c3ccc(cc3)C(F)(F)F)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O08 compound treatment 1.25169376E8 -3.13E7 -0.39 1.25457737E8 -1.7E7 -0.29 -0.4837 -0.989 3065706 Maybridge4_004540 FC(F)(F)c1ccc(cc1)C(=O)Sc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O09 compound treatment 1.24421171E8 -3.21E7 -0.4 1.26021359E8 -1.64E7 -0.28 -0.4835 -0.9846 1707697 Maybridge4_004541 Fc1ccc(cc1)n2nc(cc2NC(=O)C3CCC3)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O10 compound treatment 1.28944398E8 -2.76E7 -0.35 1.28145046E8 -1.43E7 -0.24 -0.4177 -0.9857 3065707 Maybridge4_004542 N/C(=N\O)/CS(=O)(=O)Cc1cccc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O11 compound treatment 1.15790323E8 -4.07E7 -0.51 1.17297826E8 -2.52E7 -0.43 -0.6657 -0.9964 3178808 Maybridge4_004543 COC(=O)C1SCCN1C(=O)c2cc(oc2C)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O12 compound treatment 1.19653495E8 -3.69E7 -0.46 1.23480523E8 -1.9E7 -0.32 -0.5566 -0.985 3065708 Maybridge4_004544 FC(F)(F)c1ccc(COc2ccc(C#N)cc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O13 compound treatment 1.15105589E8 -4.14E7 -0.52 1.1704599E8 -2.54E7 -0.43 -0.6748 -0.9961 3178809 Maybridge4_004545 Cc1oc(cc1C(=O)N2CCN(CC2)c3ncccc3C(F)(F)F)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O14 compound treatment 1.19857864E8 -3.67E7 -0.46 1.28703467E8 -1.37E7 -0.24 -0.4915 -0.9516 1687767 Maybridge4_004546 Clc1cccc(Cl)c1Cc2nc(cs2)C(=O)NCc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O15 compound treatment 1.25691801E8 -3.08E7 -0.39 1.34156912E8 -8290000.0 -0.14 -0.3738 -0.9075 1449045 Maybridge4_004547 COC(=O)c1c(C)oc(C)c1S(=O)(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O16 compound treatment 1.32356825E8 -2.42E7 -0.3 1.31810071E8 -1.06E7 -0.18 -0.343 -0.9703 1404470 Maybridge4_004548 CCn1nc(C)cc1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O17 compound treatment 1.30871576E8 -2.56E7 -0.32 1.23976957E8 -1.85E7 -0.32 -0.451 -1.0 3178810 Maybridge4_004549 CN(C)N/C(=N\O)/c1c(F)cccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O18 compound treatment 1.36947732E8 -1.96E7 -0.25 1.29327564E8 -1.31E7 -0.22 -0.3324 -0.999 3065709 Maybridge4_004550 N/C(=N\O)/COc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O19 compound treatment 1.30317856E8 -2.62E7 -0.33 1.21735092E8 -2.07E7 -0.35 -0.4831 -0.9993 3178811 Maybridge4_004551 Oc1cc(nc(Cc2c(Cl)cccc2Cl)n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O20 compound treatment 1.33149493E8 -2.34E7 -0.29 1.27247232E8 -1.52E7 -0.26 -0.3912 -0.9982 3065711 Maybridge4_004552 CCn1nc(C)c(Br)c1C(=O)Oc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O21 compound treatment 1.37376121E8 -1.91E7 -0.24 1.40998757E8 -1450000.0 -0.02 -0.1873 -0.7761 3178882 Maybridge4_004553 Cc1ccc(CSc2nnc([nH]2)c3ccc(cc3)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O22 compound treatment 1.35415997E8 -2.11E7 -0.26 1.27028701E8 -1.54E7 -0.26 -0.3738 -1.0 3178883 Maybridge4_004554 Cc1cc(OCc2noc(CSc3ccc(cn3)C(F)(F)F)n2)cc(C)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O23 mock treatment 1.37341397E8 -1.92E7 -0.24 1.27714062E8 -1.47E7 -0.25 -0.3484 -0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 O24 mock treatment 1.28621497E8 -2.79E7 -0.35 1.22490467E8 -2.0E7 -0.34 -0.489 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P01 compound treatment 1.30075945E8 -2.64E7 -0.33 1.14264449E8 -2.82E7 -0.48 -0.5757 -0.9833 1165145 Maybridge4_004555 CC(C)(C)c1cc(C(=O)Nc2ccc(Cl)cc2)n(Cc3ccccc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P02 compound treatment 1.25996207E8 -3.05E7 -0.38 1.12788572E8 -2.97E7 -0.51 -0.6297 -0.9903 3178884 Maybridge4_004556 CCOC(=O)c1cc(on1)c2ccnn2C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P03 compound treatment 1.07880659E8 -4.86E7 -0.61 1.0142905E8 -4.1E7 -0.7 -0.9279 -0.9975 3065712 Maybridge4_004557 Cc1cc(no1)c2onc(C)c2C(=O)Sc3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P04 compound treatment 1.18217837E8 -3.83E7 -0.48 1.10471253E8 -3.2E7 -0.55 -0.7268 -0.9979 3178885 Maybridge4_004558 Cc1nc(nc(Sc2cccc(c2)C(F)(F)F)c1C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P05 compound treatment 1.20440791E8 -3.61E7 -0.45 1.21910814E8 -2.05E7 -0.35 -0.5686 -0.9922 3065713 Maybridge4_004559 CCOC(=O)c1noc(C)c1c2csc(COc3cc(Cl)cc(Cl)c3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P06 compound treatment 1.30162292E8 -2.64E7 -0.33 1.1857432E8 -2.39E7 -0.41 -0.5227 -0.9945 3178886 Maybridge4_004560 FC(F)(F)c1ccc(cc1)c2nc(cs2)c3cc(no3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P07 compound treatment 1.29999249E8 -2.65E7 -0.33 1.23081657E8 -1.94E7 -0.33 -0.4696 -1.0 1465099 Maybridge4_004561 Cc1cc(no1)c2onc(C)c2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P08 compound treatment 1.01850233E8 -5.47E7 -0.69 9.5651485E7 -4.68E7 -0.8 -1.0513 -0.997 1505757 Maybridge4_004562 Cc1nc2ccccn2c1c3ccnn3S(=O)(=O)c4ccc(C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P09 compound treatment 1.21793479E8 -3.47E7 -0.44 1.0891333E8 -3.35E7 -0.57 -0.7139 -0.9907 3065714 Maybridge4_004563 COC(=O)c1noc(C)c1c2ccnn2C(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P10 compound treatment 1.36814066E8 -1.97E7 -0.25 1.02792273E8 -3.97E7 -0.68 -0.6547 -0.9063 3178887 Maybridge4_004564 COC(=O)c1cnn(c1/C=N/c2ccc(C)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P11 compound treatment 1.35395336E8 -2.11E7 -0.26 1.19875549E8 -2.26E7 -0.39 -0.4606 -0.983 3178888 Maybridge4_004565 CC(C)(C)c1ccc(cc1Cn2nnc(n2)c3cccc(c3)C(F)(F)F)c4ncon4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P12 compound treatment 8.9169744E7 -6.73E7 -0.84 7.5815693E7 -6.66E7 -1.14 -1.4039 -0.9891 1198897 Maybridge4_004566 CC(=O)N(C(=O)C)c1nccc(n1)c2c(C)onc2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P13 compound treatment 1.2864657E8 -2.79E7 -0.35 1.08135485E8 -3.43E7 -0.59 -0.6625 -0.9693 1188766 Maybridge4_004567 Clc1ccc(cc1)n2ccc(=O)c(n2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P14 compound treatment 1.4111285E8 -1.54E7 -0.19 1.2357635E8 -1.89E7 -0.32 -0.365 -0.9698 1729683 Maybridge4_004568 CC(C)NC(=O)n1ncc(c1c2ccc(Cl)cc2)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P15 compound treatment 1.3369086E8 -2.28E7 -0.29 1.11486217E8 -3.1E7 -0.53 -0.5772 -0.9582 1416020 Maybridge4_004569 Cc1[nH]c(=S)[nH]c(=O)c1Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P16 compound treatment 1.24328246E8 -3.22E7 -0.4 1.09388039E8 -3.31E7 -0.57 -0.6857 -0.9863 3065738 Maybridge4_004570 Cc1c(sc2nc(nn12)C(F)(F)F)C(=O)Sc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P17 compound treatment 1.30150653E8 -2.64E7 -0.33 1.12444375E8 -3.0E7 -0.51 -0.597 -0.9773 1418463 Maybridge4_004571 CCOC(=O)c1cc(C#N)c(S)nc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P18 compound treatment 1.51897717E8 -4620000.0 -0.06 7.8401748E7 -6.4E7 -1.1 -0.8162 -0.7434 3065739 Maybridge4_004572 Cn1c(S)nnc1c2ncc(cc2Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P19 compound treatment 1.33918162E8 -2.26E7 -0.28 1.1204491E8 -3.04E7 -0.52 -0.5684 -0.9592 3065740 Maybridge4_004573 Cc1onc(C(=O)NN)c1c2csc(COc3ccc(Cl)cc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P20 compound treatment 1.42115401E8 -1.44E7 -0.18 1.13128694E8 -2.93E7 -0.5 -0.4826 -0.9048 1093995 Maybridge4_004574 NC(=S)COc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P21 compound treatment 1.45112945E8 -1.14E7 -0.14 1.08632006E8 -3.38E7 -0.58 -0.5105 -0.8561 3178889 Maybridge4_004575 Cc1cc(no1)c2nc(cs2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P22 compound treatment 1.32679765E8 -2.38E7 -0.3 1.109688E8 -3.15E7 -0.54 -0.5925 -0.9614 3065741 Maybridge4_004576 CC(C)S(=O)(=O)/C(=C/N1CCC(CC1)C(F)(F)F)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P23 mock treatment 1.35360172E8 -2.12E7 -0.27 1.20205525E8 -2.22E7 -0.38 -0.4569 -0.9844 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2061 P24 mock treatment 1.35922112E8 -2.06E7 -0.26 1.24636783E8 -1.78E7 -0.3 -0.3983 -0.9966 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A01 compound treatment 1.46447513E8 1.4E7 0.18 1.47074814E8 4270000.0 0.07 0.1755 0.9251 3178890 Maybridge4_004577 CC(C)(C)c1ccc(SC(=O)c2ccc(OCC(F)(F)F)nc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A02 compound treatment 1.48175842E8 1.57E7 0.2 1.42896332E8 95200.0 0.0 0.1403 0.7129 1333720 Maybridge4_004578 COc1ccc(OCc2ncc(s2)c3ccc4OCCCOc4c3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A03 compound treatment 1.54928673E8 2.24E7 0.28 1.52176219E8 9380000.0 0.16 0.3125 0.9645 1593366 Maybridge4_004579 Cc1nn(c(N)c1c2nc(cs2)c3ccccc3)c4cc(Cl)ccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A04 compound treatment 1.564867E8 2.4E7 0.3 1.4972268E8 6920000.0 0.12 0.2966 0.917 3178891 Maybridge4_004580 Cc1ccc(cc1F)c2nc(cs2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A05 compound treatment 1.65629181E8 3.31E7 0.42 1.49408958E8 6610000.0 0.11 0.3739 0.868 3065742 Maybridge4_004581 FC(F)(F)Oc1ccc(cc1)C(=O)Nc2ccc(nc2)N3CCC(CC3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A06 compound treatment 1.52058597E8 1.96E7 0.25 1.50534855E8 7730000.0 0.13 0.2672 0.958 3178892 Maybridge4_004582 Cc1c(C#N)c(SCc2cccc(c2)C(F)(F)F)nc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A07 compound treatment 1.66140535E8 3.36E7 0.42 1.54653469E8 1.19E7 0.2 0.4419 0.9436 3178893 Maybridge4_004583 CCOC(=O)c1cc(C#N)c(Sc2ccc(C)cc2)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A08 compound treatment 1.6288544E8 3.04E7 0.38 1.44972755E8 2170000.0 0.04 0.2959 0.7724 3065743 Maybridge4_004584 Cn1nc(c2cccc(c2)C3OCCO3)c(=O)n(C)c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A09 compound treatment 1.63562354E8 3.11E7 0.39 1.62040712E8 1.92E7 0.33 0.5085 0.9965 3178894 Maybridge4_004585 Cc1nc(cs1)C(=N)NC(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A10 compound treatment 1.37472457E8 4980000.0 0.06 1.13973841E8 -2.88E7 -0.49 -0.3047 -0.6127 3065744 Maybridge4_004586 CC1=N/C(=C\c2sccc2C)/C(=O)O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A11 compound treatment 1.58701016E8 2.62E7 0.33 1.33296149E8 -9510000.0 -0.16 0.1174 0.3201 1220314 Maybridge4_004587 Cc1cc(C)n(Cc2ccccc2)c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A12 compound treatment 1.51144812E8 1.87E7 0.23 9.8832781E7 -4.4E7 -0.75 -0.3667 -0.4653 3178895 Maybridge4_004588 Cc1ccccc1c2nnc(o2)c3cc(nn3Cc4ccc(F)cc4)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A13 compound treatment 1.52118102E8 1.96E7 0.25 1.36163594E8 -6640000.0 -0.11 0.0938 0.3457 3178896 Maybridge4_004589 FC(F)(F)COc1ccc(cn1)c2nnc(SCc3ccccc3C(F)(F)F)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A14 compound treatment 1.49340915E8 1.68E7 0.21 1.30732815E8 -1.21E7 -0.21 0.0034 0.0114 3065746 Maybridge4_004590 CN(C)/C=C/C(=O)C1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A15 compound treatment 1.43244693E8 1.08E7 0.13 1.36540224E8 -6260000.0 -0.11 0.0196 0.1138 3178897 Maybridge4_004591 CCOC(=O)c1cc(C#N)c(nc1C(F)(F)F)N2CCN(CC2)C(=O)c3snnc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A16 compound treatment 1.48555903E8 1.61E7 0.2 9.7372266E7 -4.54E7 -0.78 -0.4074 -0.5071 3065747 Maybridge4_004592 CC1CCCCN1C(=S)Nc2cccc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A17 compound treatment 1.53173105E8 2.07E7 0.26 1.40319646E8 -2480000.0 -0.04 0.1534 0.5836 3178898 Maybridge4_004593 FC(F)(F)c1ccc(nc1)c2nnc(c3ccccn3)c(n2)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A18 compound treatment 1.51573694E8 1.91E7 0.24 1.43242397E8 441000.0 0.01 0.1746 0.7291 3065748 Maybridge4_004594 CC(C)n1c(=S)[nH]c2cc(ccc12)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A19 compound treatment 1.53609589E8 2.11E7 0.26 1.53383364E8 1.06E7 0.18 0.3154 0.9828 3178899 Maybridge4_004595 COc1ccc(OCC(=N)NC(=S)Nc2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A20 compound treatment 1.54631111E8 2.21E7 0.28 1.33894593E8 -8910000.0 -0.15 0.0886 0.2796 3065749 Maybridge4_004596 Clc1ccc(NC(=C(C#N)C#N)NC(=O)c2ccccc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A21 compound treatment 1.61145978E8 2.87E7 0.36 1.49117543E8 6320000.0 0.11 0.3306 0.8808 3178900 Maybridge4_004597 FC(F)(F)c1cc(nc(Sc2ccccc2NC(=O)c3cccs3)c1C#N)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A22 mock treatment 1.58514144E8 2.6E7 0.33 1.68280426E8 2.55E7 0.44 0.5392 0.9898 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A23 mock treatment 1.50622374E8 1.81E7 0.23 9.8301082E7 -4.45E7 -0.76 -0.3778 -0.4752 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 A24 mock treatment 1.11113228E8 -2.14E7 -0.27 1.57700423E8 1.49E7 0.26 -0.0093 -0.0251 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B01 mock treatment 1.51825462E8 1.93E7 0.24 1.56795392E8 1.4E7 0.24 0.3409 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B02 mock treatment 1.67826449E8 3.53E7 0.44 1.56104348E8 1.33E7 0.23 0.4745 0.9521 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B03 mock treatment 1.08011834E8 -2.45E7 -0.31 1.56090843E8 1.33E7 0.23 -0.0563 -0.1473 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B04 mock treatment 1.10966039E8 -2.15E7 -0.27 1.51577456E8 8780000.0 0.15 -0.0847 -0.2741 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B05 mock treatment 1.03910216E8 -2.86E7 -0.36 1.59956865E8 1.72E7 0.29 -0.0459 -0.099 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B06 mock treatment 9.4102118E7 -3.84E7 -0.48 1.6008044E8 1.73E7 0.3 -0.1314 -0.2325 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B07 mock treatment 9.4427469E7 -3.81E7 -0.48 1.47363862E8 4560000.0 0.08 -0.2824 -0.5837 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B08 mock treatment 1.12027325E8 -2.05E7 -0.26 1.61064636E8 1.83E7 0.31 0.0395 0.0978 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B09 mock treatment 1.13682639E8 -1.88E7 -0.24 1.61854927E8 1.91E7 0.33 0.0638 0.1585 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B10 mock treatment 1.06847916E8 -2.56E7 -0.32 1.59903416E8 1.71E7 0.29 -0.0205 -0.047 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B11 mock treatment 1.37040375E8 4550000.0 0.06 1.47787237E8 4990000.0 0.09 0.1007 0.9808 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B12 mock treatment 1.02460621E8 -3.0E7 -0.38 1.4910454E8 6300000.0 0.11 -0.1901 -0.4851 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B13 mock treatment 1.04524935E8 -2.8E7 -0.35 1.63377664E8 2.06E7 0.35 0.001 0.002 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B14 mock treatment 9.6212621E7 -3.63E7 -0.46 1.52872895E8 1.01E7 0.17 -0.1999 -0.4107 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B15 mock treatment 1.69405273E8 3.69E7 0.46 1.67998526E8 2.52E7 0.43 0.6324 0.9994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B16 mock treatment 9.075461E7 -4.17E7 -0.52 1.67271167E8 2.45E7 0.42 -0.074 -0.1104 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B17 mock treatment 9.4758707E7 -3.77E7 -0.47 1.47132512E8 4330000.0 0.07 -0.2823 -0.5892 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B18 mock treatment 9.0533076E7 -4.2E7 -0.53 1.55582128E8 1.28E7 0.22 -0.2175 -0.3815 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B19 mock treatment 1.61788796E8 2.93E7 0.37 1.48450898E8 5650000.0 0.1 0.3283 0.8638 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B20 mock treatment 1.26528217E8 -5960000.0 -0.07 1.52670587E8 9870000.0 0.17 0.0666 0.3603 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B21 mock treatment 1.57996095E8 2.55E7 0.32 1.64861234E8 2.21E7 0.38 0.4933 0.9966 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B22 mock treatment 9.7737207E7 -3.48E7 -0.44 1.5569758E8 1.29E7 0.22 -0.1522 -0.3114 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B23 mock treatment 1.52516052E8 2.0E7 0.25 1.20736716E8 -2.21E7 -0.38 -0.0894 -0.1972 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 B24 mock treatment 1.2419914E8 -8290000.0 -0.1 1.60773754E8 1.8E7 0.31 0.144 0.4434 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C01 compound treatment 1.22351695E8 -1.01E7 -0.13 1.21165237E8 -2.16E7 -0.37 -0.3518 -0.8984 3065750 Maybridge4_004598 FC(F)(F)c1cccc(NC(=O)CCn2cccc(c2=O)C(F)(F)F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C02 compound treatment 1.14053206E8 -1.84E7 -0.23 1.11687133E8 -3.11E7 -0.53 -0.5402 -0.9303 3178901 Maybridge4_004599 Oc1ccc2c(CSc3ccc(Cl)cc3)cc(=O)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C03 compound treatment 1.36479525E8 3990000.0 0.05 1.38535213E8 -4270000.0 -0.07 -0.0163 -0.1837 3178902 Maybridge4_004600 CN(CCOC(=O)c1snnc1C)c2ccc(C#N)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C04 compound treatment 1.26905942E8 -5590000.0 -0.07 1.36549293E8 -6250000.0 -0.11 -0.1252 -0.9789 1339676 Maybridge4_004601 Cn1nc(cc1C(=O)Nc2cccnc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C05 compound treatment 1.34223419E8 1730000.0 0.02 1.37468407E8 -5330000.0 -0.09 -0.0492 -0.5241 3065771 Maybridge4_004602 CCCNC(=O)Nc1ccc(nc1)N2CCC(CC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C06 compound treatment 1.31037126E8 -1450000.0 -0.02 1.29542156E8 -1.33E7 -0.23 -0.1734 -0.7615 1741890 Maybridge4_004603 Cc1cc(C(=O)Nc2ccc(C)cc2)n(Cc3ccc(C)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C07 compound treatment 1.2586762E8 -6620000.0 -0.08 1.41464098E8 -1340000.0 -0.02 -0.0749 -0.8695 3065772 Maybridge4_004604 CCOC(=O)c1cc(C#N)c(Nc2ccccc2OC)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C08 compound treatment 1.30190341E8 -2300000.0 -0.03 1.4094094E8 -1860000.0 -0.03 -0.0429 -0.9988 3065773 Maybridge4_004605 N#Cc1ccc(nc1)N2CCCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C09 compound treatment 1.24397438E8 -8090000.0 -0.1 1.3251013E8 -1.03E7 -0.18 -0.1964 -0.9657 3065774 Maybridge4_004606 Cc1nc(cs1)C(=N)NC(=O)c2ccc(OC(F)(F)F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C10 compound treatment 1.43765282E8 1.13E7 0.14 1.57456085E8 1.47E7 0.25 0.2774 0.9632 3065775 Maybridge4_004607 N[C@@H](Cc1ccc(OC(F)(F)F)cc1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C11 compound treatment 1.23727781E8 -8760000.0 -0.11 1.49899006E8 7100000.0 0.12 0.0082 0.0499 3065776 Maybridge4_004608 Cn1c(SCC(=O)Nc2cccc(Cl)c2)nnc1c3ccc(OCC(F)(F)F)nc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C12 compound treatment 1.2769167E8 -4800000.0 -0.06 1.29040562E8 -1.38E7 -0.24 -0.2091 -0.8602 3065777 Maybridge4_004609 Cc1cc(nn1C(C)(C)C)C(=O)Nc2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C13 compound treatment 1.21818674E8 -1.07E7 -0.13 1.33148855E8 -9650000.0 -0.17 -0.2115 -0.9946 3178903 Maybridge4_004610 CSc1nnc(c2cc(OCC(F)(F)F)nc(OCC(F)(F)F)c2)n1Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C14 compound treatment 1.21407055E8 -1.11E7 -0.14 1.28266811E8 -1.45E7 -0.25 -0.2742 -0.9622 3065778 Maybridge4_004611 Fc1ccc(SCC(=O)C2(CC3CC4CC(C3)C2)C4)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C15 compound treatment 1.42175284E8 9680000.0 0.12 1.47708769E8 4910000.0 0.08 0.1453 0.9838 3178904 Maybridge4_004612 FC(F)(F)c1ccc(nc1)c2nnc(SCC(=O)Nc3cccc(Cl)c3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C16 compound treatment 1.27328806E8 -5160000.0 -0.06 1.37431789E8 -5370000.0 -0.09 -0.1108 -0.9853 3065781 Maybridge4_004613 Cc1cccc(NC(=S)N2CCCCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C17 compound treatment 1.58375969E8 2.59E7 0.32 1.5333287E8 1.05E7 0.18 0.3571 0.9614 3178905 Maybridge4_004614 Fc1cccc(c1)C(=O)CSC2=NNC(S2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C18 compound treatment 9.8770187E7 -3.37E7 -0.42 1.0250409E8 -4.03E7 -0.69 -0.7869 -0.9724 3065782 Maybridge4_004615 Cn1c(SCC=C)ncc1c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C19 compound treatment 1.29968211E8 -2520000.0 -0.03 1.29367458E8 -1.34E7 -0.23 -0.185 -0.7969 3178906 Maybridge4_004616 Cc1ccc(NC(=S)NC(=N)COc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C20 compound treatment 1.22828726E8 -9660000.0 -0.12 1.25528071E8 -1.73E7 -0.3 -0.2948 -0.9225 3065783 Maybridge4_004617 Sc1nnc(SCC2CC2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C21 compound treatment 1.26760185E8 -5730000.0 -0.07 1.23514378E8 -1.93E7 -0.33 -0.2843 -0.8414 1187470 Maybridge4_004618 NC(=S)c1ccc(nc1)n2cncn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C22 mock treatment 1.29758245E8 -2730000.0 -0.03 1.44972757E8 2170000.0 0.04 0.002 0.0404 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C23 mock treatment 1.29136779E8 -3350000.0 -0.04 1.32709068E8 -1.01E7 -0.17 -0.1519 -0.8544 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 C24 mock treatment 1.15690808E8 -1.68E7 -0.21 1.31517249E8 -1.13E7 -0.19 -0.2856 -0.9991 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D01 mock treatment 1.41813243E8 9320000.0 0.12 1.39839195E8 -2960000.0 -0.05 0.0468 0.3675 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D02 mock treatment 9.141412E7 -4.11E7 -0.52 1.38625972E8 -4180000.0 -0.07 -0.4149 -0.7975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D03 mock treatment 1.47840727E8 1.53E7 0.19 1.41739233E8 -1060000.0 -0.02 0.1233 0.6375 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D04 mock treatment 9.2651205E7 -3.98E7 -0.5 1.42052013E8 -749000.0 -0.01 -0.3625 -0.725 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D05 mock treatment 1.25951791E8 -6540000.0 -0.08 1.33515256E8 -9290000.0 -0.16 -0.1704 -0.9526 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D06 mock treatment 8.8310855E7 -4.42E7 -0.55 1.40971273E8 -1830000.0 -0.03 -0.414 -0.7459 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D07 mock treatment 1.5356101E8 2.11E7 0.26 1.46621845E8 3820000.0 0.07 0.2331 0.8563 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D08 mock treatment 1.37247209E8 4760000.0 0.06 1.43708171E8 907000.0 0.02 0.0532 0.8624 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D09 mock treatment 1.42439672E8 9950000.0 0.12 1.63303238E8 2.05E7 0.35 0.3364 0.9032 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D10 mock treatment 1.60776744E8 2.83E7 0.35 1.41898448E8 -903000.0 -0.02 0.24 0.6757 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D11 mock treatment 1.35523322E8 3030000.0 0.04 1.42823793E8 22600.0 0.0 0.0272 0.7143 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D12 mock treatment 9.9637637E7 -3.29E7 -0.41 1.42096857E8 -704000.0 -0.01 -0.2999 -0.7275 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D13 mock treatment 1.19870944E8 -1.26E7 -0.16 1.41059451E8 -1740000.0 -0.03 -0.133 -0.8258 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D14 mock treatment 1.30090537E8 -2400000.0 -0.03 1.38925672E8 -3880000.0 -0.07 -0.0682 -0.9362 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D15 mock treatment 1.34825147E8 2330000.0 0.03 1.47136236E8 4340000.0 0.07 0.0732 0.9173 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D16 mock treatment 9.6076051E7 -3.64E7 -0.46 1.4371613E8 915000.0 0.02 -0.3119 -0.6825 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D17 mock treatment 1.32360911E8 -130000.0 0.0 1.42987439E8 186000.0 0.0 0.0011 0.3066 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D18 mock treatment 1.10252688E8 -2.22E7 -0.28 1.40538362E8 -2260000.0 -0.04 -0.2247 -0.7976 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D19 mock treatment 1.34435486E8 1940000.0 0.02 1.34419296E8 -8380000.0 -0.14 -0.0842 -0.5786 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D20 mock treatment 1.36672523E8 4180000.0 0.05 1.42912707E8 112000.0 0.0 0.0384 0.7324 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D21 mock treatment 1.55448309E8 2.3E7 0.29 1.35761782E8 -7040000.0 -0.12 0.1184 0.3794 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D22 mock treatment 1.33142669E8 651000.0 0.01 1.40582389E8 -2220000.0 -0.04 -0.0211 -0.5426 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D23 mock treatment 1.21161309E8 -1.13E7 -0.14 1.33249402E8 -9550000.0 -0.16 -0.2161 -0.9976 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 D24 mock treatment 1.2101862E8 -1.15E7 -0.14 1.28303297E8 -1.45E7 -0.25 -0.2773 -0.9664 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E01 compound treatment 9.15789E7 -4.09E7 -0.51 9.6515596E7 -4.63E7 -0.79 -0.9232 -0.9779 3178907 Maybridge4_004619 FC(F)(F)c1cccn(CCC(=O)Sc2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E02 compound treatment 1.082503E8 -2.42E7 -0.3 1.15223478E8 -2.76E7 -0.47 -0.5488 -0.9774 1539590 Maybridge4_004620 Oc1ccc2c(CSc3ccccn3)cc(=O)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E03 compound treatment 1.04969555E8 -2.75E7 -0.35 1.19338287E8 -2.35E7 -0.4 -0.5281 -0.9972 3178908 Maybridge4_004621 NC(=S)c1ccc(nc1)N2CCC(CC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E04 compound treatment 1.13428183E8 -1.91E7 -0.24 1.22296633E8 -2.05E7 -0.35 -0.4173 -0.9825 3178909 Maybridge4_004622 Cc1cccc(Cl)c1OC(=O)c2cc(nn2C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E05 compound treatment 1.20282596E8 -1.22E7 -0.15 1.32192168E8 -1.06E7 -0.18 -0.2367 -0.9964 3065784 Maybridge4_004623 OC(=O)CCn1cc(ccc1=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E06 compound treatment 1.15872392E8 -1.66E7 -0.21 1.33287255E8 -9510000.0 -0.16 -0.2626 -0.9925 1605604 Maybridge4_004624 Cc1cc(C(=O)Sc2ccccc2)n(Cc3ccc(C)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E07 compound treatment 1.22389486E8 -1.01E7 -0.13 1.2483862E8 -1.8E7 -0.31 -0.307 -0.9232 3065785 Maybridge4_004625 FC(F)(F)c1cccn(Cc2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E08 compound treatment 1.23554174E8 -8940000.0 -0.11 1.4167931E8 -1120000.0 -0.02 -0.0929 -0.8163 3178983 Maybridge4_004626 O=c1[nH]nc(SCc2ccccc2)n1c3ccc(OCc4ccccc4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E09 compound treatment 1.17936E8 -1.46E7 -0.18 1.27980562E8 -1.48E7 -0.25 -0.3085 -0.987 3065786 Maybridge4_004627 Cn1c(S)nnc1Cn2cc(ccc2=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E10 compound treatment 1.23386988E8 -9100000.0 -0.11 1.30819108E8 -1.2E7 -0.21 -0.2258 -0.9618 3178984 Maybridge4_004628 CC(=O)N/C(=C/c1ccc(Cl)c(Cl)c1)/C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E11 compound treatment 1.22732696E8 -9760000.0 -0.12 1.26348999E8 -1.65E7 -0.28 -0.2857 -0.9304 3065787 Maybridge4_004629 Cn1c(SCc2ccc(cc2)C(F)(F)F)nnc1c3ccc(OCC(F)(F)F)nc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E12 compound treatment 1.1875795E8 -1.37E7 -0.17 1.23206683E8 -1.96E7 -0.34 -0.359 -0.9521 3178985 Maybridge4_004630 Clc1ccc(cc1)c2nnc(SCC3CC3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E13 compound treatment 1.19283246E8 -1.32E7 -0.17 1.37004234E8 -5800000.0 -0.1 -0.1873 -0.9699 3178986 Maybridge4_004631 Cc1ccccc1NC(=O)c2cccc(Cn3cc(ccc3=O)C(F)(F)F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E14 compound treatment 1.22806488E8 -9680000.0 -0.12 1.44007861E8 1210000.0 0.02 -0.0713 -0.5786 1516971 Maybridge4_004632 Cc1ccc(cc1)C(=O)CSc2nnc(o2)c3cc(nn3Cc4cccc(C)c4)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E15 compound treatment 1.22095513E8 -1.04E7 -0.13 1.33197732E8 -9600000.0 -0.16 -0.2085 -0.9934 3178987 Maybridge4_004633 NNC(=N)c1ccc(cn1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E16 compound treatment 1.32167042E8 -324000.0 0.0 1.29243587E8 -1.36E7 -0.23 -0.167 -0.7194 3065788 Maybridge4_004634 CC(C)N(CCC#N)CN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E17 compound treatment 1.42139421E8 9650000.0 0.12 1.54177623E8 1.14E7 0.19 0.2233 0.9738 3065812 Maybridge4_004635 CC(C)c1ccc(NC(=O)CSC2=NNC(S2)c3ccccn3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E18 compound treatment 1.15602281E8 -1.69E7 -0.21 1.26142176E8 -1.67E7 -0.29 -0.3515 -0.9893 3065813 Maybridge4_004636 Clc1ccc(N/C(=N\C#N)/Oc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E19 compound treatment 1.16261441E8 -1.62E7 -0.2 1.19578251E8 -2.32E7 -0.4 -0.4251 -0.9517 1232015 Maybridge4_004637 Sc1nc2CCCCc2c(c3cccs3)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E20 compound treatment 1.25454254E8 -7040000.0 -0.09 1.34002945E8 -8800000.0 -0.15 -0.1689 -0.9676 3065814 Maybridge4_004638 CC(Sc1ccc(C)cc1)C(=O)c2ccc(C)c(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E21 compound treatment 1.22315617E8 -1.02E7 -0.13 1.25989051E8 -1.68E7 -0.29 -0.2938 -0.9331 3065815 Maybridge4_004639 CCOC(=O)c1nc(C)nc(Sc2nnc([nH]2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E22 mock treatment 1.24655628E8 -7840000.0 -0.1 1.30301206E8 -1.25E7 -0.21 -0.2208 -0.9377 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E23 mock treatment 1.28391484E8 -4100000.0 -0.05 1.22849133E8 -2.0E7 -0.34 -0.2779 -0.8045 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 E24 mock treatment 1.14209578E8 -1.83E7 -0.23 1.14096021E8 -2.87E7 -0.49 -0.5096 -0.9398 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F01 mock treatment 1.24855554E8 -7640000.0 -0.1 1.30225756E8 -1.26E7 -0.22 -0.2199 -0.9335 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F02 mock treatment 1.32971395E8 480000.0 0.01 1.39566989E8 -3230000.0 -0.06 -0.0349 -0.6265 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F03 mock treatment 1.2519117E8 -7300000.0 -0.09 1.45203604E8 2400000.0 0.04 -0.0357 -0.3554 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F04 mock treatment 1.42561478E8 1.01E7 0.13 1.48617246E8 5820000.0 0.1 0.1597 0.9931 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F05 mock treatment 1.33353812E8 863000.0 0.01 1.38441005E8 -4360000.0 -0.07 -0.0451 -0.5983 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F06 mock treatment 1.29246022E8 -3250000.0 -0.04 1.31495224E8 -1.13E7 -0.19 -0.1656 -0.8375 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F07 mock treatment 8.8211564E7 -4.43E7 -0.56 1.47244587E8 4440000.0 0.08 -0.339 -0.6046 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F08 mock treatment 1.32264665E8 -227000.0 0.0 1.4325653E8 455000.0 0.01 0.0035 0.4221 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F09 mock treatment 1.24833766E8 -7660000.0 -0.1 1.35004098E8 -7800000.0 -0.13 -0.1623 -0.987 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F10 mock treatment 1.32724353E8 233000.0 0.0 1.3290264E8 -9900000.0 -0.17 -0.1177 -0.6948 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F11 mock treatment 1.40104536E8 7610000.0 0.1 1.26046335E8 -1.68E7 -0.29 -0.1353 -0.4475 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F12 mock treatment 1.28611793E8 -3880000.0 -0.05 1.39962175E8 -2840000.0 -0.05 -0.0688 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F13 mock treatment 8.6354104E7 -4.61E7 -0.58 1.34196753E8 -8600000.0 -0.15 -0.5134 -0.8597 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F14 mock treatment 1.26290527E8 -6200000.0 -0.08 1.01399587E8 -4.14E7 -0.71 -0.5561 -0.78 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F15 mock treatment 1.27438849E8 -5050000.0 -0.06 1.41959635E8 -842000.0 -0.01 -0.055 -0.8462 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F16 mock treatment 1.5027219E8 1.78E7 0.22 1.41776472E8 -1020000.0 -0.02 0.1453 0.6495 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F17 mock treatment 1.33391024E8 900000.0 0.01 1.33430812E8 -9370000.0 -0.16 -0.1054 -0.6557 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F18 mock treatment 1.28091743E8 -4400000.0 -0.06 1.25197097E8 -1.76E7 -0.3 -0.2521 -0.8229 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F19 mock treatment 1.26074119E8 -6420000.0 -0.08 1.2056367E8 -2.22E7 -0.38 -0.3261 -0.8381 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F20 mock treatment 1.27107591E8 -5380000.0 -0.07 1.24076112E8 -1.87E7 -0.32 -0.2744 -0.8377 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F21 mock treatment 1.21382995E8 -1.11E7 -0.14 1.28497909E8 -1.43E7 -0.24 -0.2717 -0.9643 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F22 mock treatment 1.31456768E8 -1030000.0 -0.01 1.45598848E8 2800000.0 0.05 0.0247 0.4976 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F23 mock treatment 1.14703328E8 -1.78E7 -0.22 1.29444368E8 -1.34E7 -0.23 -0.3195 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 F24 mock treatment 1.13718097E8 -1.88E7 -0.24 1.16775513E8 -2.6E7 -0.45 -0.4815 -0.9556 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G01 compound treatment 1.68395838E8 3.59E7 0.45 1.70890169E8 2.81E7 0.48 0.6585 0.9995 3065816 Maybridge4_004640 Cc1nc(N)nc(CSc2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G02 compound treatment 1.74741432E8 4.23E7 0.53 1.84763224E8 4.2E7 0.72 0.8827 0.9888 3065817 Maybridge4_004641 Oc1ccc2c(CSc3nnc([nH]3)c4cccs4)cc(=O)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G03 compound treatment 1.75070311E8 4.26E7 0.53 1.83070724E8 4.03E7 0.69 0.8651 0.9921 1387671 Maybridge4_004642 CN(CCOC(=O)Nc1cccc(Cl)c1)c2ccc(C#N)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G04 compound treatment 1.78299585E8 4.58E7 0.57 1.78588246E8 3.58E7 0.61 0.8395 0.9995 1420583 Maybridge4_004643 Clc1ccc(CSc2n[nH]c(=O)n2C3CC4CC3C=C4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G05 compound treatment 1.81318783E8 4.88E7 0.61 1.93149036E8 5.03E7 0.86 1.0425 0.986 3178988 Maybridge4_004644 COC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G06 compound treatment 1.67483968E8 3.5E7 0.44 1.78646686E8 3.58E7 0.61 0.7443 0.9865 3065818 Maybridge4_004645 Cc1cc(nn1Cc2ccc(C)cc2)C(=O)Sc3cccc(Cl)c3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G07 compound treatment 1.91032176E8 5.85E7 0.73 1.96754843E8 5.4E7 0.92 1.1723 0.9936 3178989 Maybridge4_004646 FC(F)(F)c1cccn(CC(=O)c2ccc(Cl)cc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G08 compound treatment 1.91969548E8 5.95E7 0.75 2.00289997E8 5.75E7 0.98 1.2234 0.9907 1219573 Maybridge4_004647 CC(C)(C)c1cc(NC(=O)CSc2n[nH]c(=O)n2c3ccc4OCCOc4c3)cc(c1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G09 compound treatment 1.97854361E8 6.54E7 0.82 1.98213206E8 5.54E7 0.95 1.2505 0.9974 3065819 Maybridge4_004648 CCOC(=O)c1cnc(nc1Sc2nnc([nH]2)c3cccs3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G10 compound treatment 1.85925584E8 5.34E7 0.67 1.89030902E8 4.62E7 0.79 1.0336 0.9966 1396971 Maybridge4_004649 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c2nnc(S)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G11 compound treatment 1.6646064E8 3.4E7 0.43 1.73374681E8 3.06E7 0.52 0.6714 0.9948 3065820 Maybridge4_004650 CCOC(=O)c1cc(C#N)c(Sc2ccccc2NC(=O)c3ccccc3)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G12 compound treatment 1.64036839E8 3.15E7 0.4 1.90094835E8 4.73E7 0.81 0.8523 0.9458 1227698 Maybridge4_004651 Cc1cccc(Cn2nc(cc2C(=O)Nc3cccnc3)C(C)(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G13 compound treatment 1.68047772E8 3.56E7 0.45 1.78871875E8 3.61E7 0.62 0.752 0.9873 3065822 Maybridge4_004652 FC(F)(F)c1ccc(=O)n(Cc2cccc(c2)C(=O)Sc3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G14 compound treatment 1.90458999E8 5.8E7 0.73 1.84684156E8 4.19E7 0.72 1.0212 1.0 3178991 Maybridge4_004653 CCOC(=O)C1CCN(CC1)c2nc(c(cc2C#N)C(=O)OCC)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G15 compound treatment 1.0769322E8 -2.48E7 -0.31 1.12589221E8 -3.02E7 -0.52 -0.5857 -0.9704 1653461 Maybridge4_004654 CC(=O)N1CCN(CC1)c2nc3ccc(Cl)cc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G16 compound treatment 1.82160618E8 4.97E7 0.62 1.83595387E8 4.08E7 0.7 0.9344 0.9984 3178992 Maybridge4_004655 CC(C)N(CCC#N)C(=S)Nc1c(C)cccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G17 compound treatment 1.80070715E8 4.76E7 0.6 1.98073328E8 5.53E7 0.95 1.0911 0.9753 3065823 Maybridge4_004656 COC(=N)NC(=S)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G18 compound treatment 1.82990179E8 5.05E7 0.63 1.8561118E8 4.28E7 0.73 0.9661 0.9974 1122990 Maybridge4_004657 CC(C)NC(=O)Nc1nc(Nc2ccc(Cl)cc2)n[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G19 compound treatment 1.53300155E8 2.08E7 0.26 1.53547802E8 1.07E7 0.18 0.3147 0.9853 3178993 Maybridge4_004658 N1N=C(NC1c2cccnc2)c3cnccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G20 compound treatment 1.67156363E8 3.47E7 0.43 1.81264617E8 3.85E7 0.66 0.7731 0.9797 1235857 Maybridge4_004659 Cc1c(C#N)c(=N)n(nc1C(=O)Nc2ccccc2)c3ccc(cc3)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G21 compound treatment 1.78943074E8 4.65E7 0.58 1.89413351E8 4.66E7 0.8 0.9762 0.9881 3178994 Maybridge4_004660 CCOC(=O)c1sc2nc(c(cc2c1NC(=O)C)C(=O)OCC)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G22 mock treatment 1.71806648E8 3.93E7 0.49 1.91330038E8 4.85E7 0.83 0.9361 0.969 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G23 mock treatment 1.81946884E8 4.95E7 0.62 1.80331268E8 3.75E7 0.64 0.893 0.9998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 G24 mock treatment 1.69922454E8 3.74E7 0.47 1.82329109E8 3.95E7 0.68 0.8105 0.9841 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H01 mock treatment 1.7955875E8 4.71E7 0.59 1.98963947E8 5.62E7 0.96 1.0973 0.9726 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H02 mock treatment 1.89034717E8 5.65E7 0.71 1.39210672E8 -3590000.0 -0.06 0.4581 0.6434 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H03 mock treatment 1.94797613E8 6.23E7 0.78 2.12943274E8 7.01E7 1.2 1.4017 0.9784 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H04 mock treatment 1.97267148E8 6.48E7 0.81 2.09506753E8 6.67E7 1.14 1.382 0.9861 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H05 mock treatment 2.01310086E8 6.88E7 0.86 2.07694868E8 6.49E7 1.11 1.3959 0.9922 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H06 mock treatment 1.9532742E8 6.28E7 0.79 2.09389052E8 6.66E7 1.14 1.3634 0.9838 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H07 mock treatment 1.94813468E8 6.23E7 0.78 2.10015264E8 6.72E7 1.15 1.3664 0.9823 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H08 mock treatment 1.93370122E8 6.09E7 0.76 1.79086043E8 3.63E7 0.62 0.9792 0.9947 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H09 mock treatment 1.85857515E8 5.34E7 0.67 2.02723135E8 5.99E7 1.03 1.1987 0.9786 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H10 mock treatment 1.90766473E8 5.83E7 0.73 1.99433389E8 5.66E7 0.97 1.2024 0.9903 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H11 mock treatment 1.84192153E8 5.17E7 0.65 2.00074602E8 5.73E7 0.98 1.1519 0.9799 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H12 mock treatment 1.89119222E8 5.66E7 0.71 2.01965692E8 5.92E7 1.01 1.2184 0.9849 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H13 mock treatment 1.85073962E8 5.26E7 0.66 2.06277356E8 6.35E7 1.09 1.2348 0.9714 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H14 mock treatment 1.18423088E8 -1.41E7 -0.18 1.89980514E8 4.72E7 0.81 0.4463 0.5399 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H15 mock treatment 1.87414969E8 5.49E7 0.69 2.09402859E8 6.66E7 1.14 1.2934 0.9709 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H16 mock treatment 1.79639253E8 4.71E7 0.59 1.44472084E8 1670000.0 0.03 0.4384 0.7404 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H17 mock treatment 1.90509244E8 5.8E7 0.73 2.11394751E8 6.86E7 1.17 1.3449 0.9735 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H18 mock treatment 1.83132072E8 5.06E7 0.64 1.93130487E8 5.03E7 0.86 1.0584 0.9888 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H19 mock treatment 1.9683456E8 6.43E7 0.81 1.90117234E8 4.73E7 0.81 1.1435 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H20 mock treatment 1.91096122E8 5.86E7 0.74 2.2579029E8 8.3E7 1.42 1.5244 0.953 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H21 mock treatment 1.90909675E8 5.84E7 0.73 2.03585133E8 6.08E7 1.04 1.2539 0.9853 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H22 mock treatment 1.7962459E8 4.71E7 0.59 1.97791772E8 5.5E7 0.94 1.0837 0.9749 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H23 mock treatment 1.80484406E8 4.8E7 0.6 1.95769683E8 5.3E7 0.91 1.0669 0.9802 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 H24 mock treatment 1.80374319E8 4.79E7 0.6 1.79408749E8 3.66E7 0.63 0.8678 0.9998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I01 compound treatment 1.46100807E8 1.36E7 0.17 1.44723069E8 1920000.0 0.03 0.144 0.8281 3178995 Maybridge4_004661 FC(F)(F)COc1ccc(cn1)C(=O)NC(=O)NN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I02 compound treatment 1.54177427E8 2.17E7 0.27 1.51808741E8 9010000.0 0.15 0.3014 0.9638 3065824 Maybridge4_004662 Oc1nnc(SCc2cc(=O)oc3cc(O)ccc23)n1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I03 compound treatment 1.52347613E8 1.99E7 0.25 1.22500724E8 -2.03E7 -0.35 -0.0696 -0.1628 3178996 Maybridge4_004663 Cc1noc(COc2ccccc2)c1C(=O)Sc3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I04 compound treatment 1.63568684E8 3.11E7 0.39 1.71313503E8 2.85E7 0.49 0.6208 0.9938 3065825 Maybridge4_004664 Cc1c(C#N)c(Sc2ccccc2Cl)nc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I05 compound treatment 1.63342062E8 3.09E7 0.39 1.71224496E8 2.84E7 0.49 0.6177 0.9936 3178997 Maybridge4_004665 COC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)Nc3ccc(Cl)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I06 compound treatment 1.72770383E8 4.03E7 0.51 1.79662584E8 3.69E7 0.63 0.8035 0.9939 1622413 Maybridge4_004666 COc1ccc(SC(=O)c2cc(C)n(Cc3c(Cl)cccc3Cl)n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I07 compound treatment 1.9785492E8 6.54E7 0.82 1.66238564E8 2.34E7 0.4 0.8635 0.9459 3178998 Maybridge4_004667 FC(F)(F)c1ccc(=O)n(CC(=O)c2ccc(C#N)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I08 compound treatment 1.83548424E8 5.11E7 0.64 2.09395365E8 6.66E7 1.14 1.259 0.9628 3065827 Maybridge4_004668 CSc1n[nH]c(=O)n1c2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I09 compound treatment 1.63576381E8 3.11E7 0.39 1.45765258E8 2960000.0 0.05 0.3116 0.7924 3065847 Maybridge4_004669 CCOC(=O)c1cc(C#N)c(Sc2n[nH]c(=O)n2Cc3ccc(cc3)C(F)(F)F)nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I10 compound treatment 1.72397094E8 3.99E7 0.5 1.72204799E8 2.94E7 0.5 0.7099 1.0 3065848 Maybridge4_004670 CC(C)(C)NC(=O)[C@H]1C[C@H]2CCCC[C@H]2CN1C(=O)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I11 compound treatment 1.88278042E8 5.58E7 0.7 1.88414121E8 4.56E7 0.78 1.047 0.9985 3065849 Maybridge4_004671 FC(F)(F)c1ccc(nc1)C(=N)NC(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I12 compound treatment 1.65598183E8 3.31E7 0.42 1.42294356E8 -507000.0 -0.01 0.2875 0.6922 1418931 Maybridge4_004672 Cc1cc(C)c(Cn2nc(cc2C(=O)NN3CCOCC3)C(C)(C)C)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I13 compound treatment 1.58700711E8 2.62E7 0.33 1.35365628E8 -7440000.0 -0.13 0.1425 0.4041 3065850 Maybridge4_004673 FC(F)(F)c1ccc(=O)n(Cc2cccc(c2)C(=O)NC(=N)c3ccc(Cl)cc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I14 compound treatment 1.75453117E8 4.3E7 0.54 1.56066488E8 1.33E7 0.23 0.5417 0.9262 1208016 Maybridge4_004674 COC(=O)[C@@H](NC(=O)c1cc(C)on1)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I15 compound treatment 1.78136182E8 4.56E7 0.57 1.57346333E8 1.45E7 0.25 0.5809 0.9304 1224162 Maybridge4_004675 CC(C)(C)C(=O)N1CCN(CC1)c2nc3ccc(Cl)cc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I16 compound treatment 1.91758178E8 5.93E7 0.74 1.57818789E8 1.5E7 0.26 0.7075 0.8994 3065852 Maybridge4_004676 CCN(C(=S)Nc1ccc(C)cc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I17 compound treatment 1.7694777E8 4.45E7 0.56 1.61090459E8 1.83E7 0.31 0.6157 0.9627 3178999 Maybridge4_004677 Clc1ccc(cc1)c2nnc(Sc3nc(ns3)c4cccs4)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I18 compound treatment 1.67263477E8 3.48E7 0.44 1.44043378E8 1240000.0 0.02 0.3235 0.7407 3065853 Maybridge4_004678 CCCNC(=O)Nc1nc(Nc2ccc(Cl)cc2)n[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I19 compound treatment 1.81453904E8 4.9E7 0.61 1.68460698E8 2.57E7 0.44 0.7449 0.9865 3179000 Maybridge4_004679 FC(F)(F)c1ccncc1C(=O)NC(=N)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I20 compound treatment 1.70429853E8 3.79E7 0.48 1.54534444E8 1.17E7 0.2 0.4785 0.9264 3179001 Maybridge4_004680 CC(Sc1ccc(C)cc1)C(=O)Nc2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I21 compound treatment 1.47854775E8 1.54E7 0.19 1.30431454E8 -1.24E7 -0.21 -0.0134 -0.047 3065854 Maybridge4_004681 Sc1nnc(s1)c2cnccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I22 mock treatment 1.62858279E8 3.04E7 0.38 1.56655526E8 1.39E7 0.24 0.4371 0.974 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I23 mock treatment 1.7062051E8 3.81E7 0.48 1.62553589E8 1.98E7 0.34 0.5773 0.9856 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 I24 mock treatment 1.69548357E8 3.71E7 0.46 1.49780437E8 6980000.0 0.12 0.4132 0.8609 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J01 mock treatment 1.39789858E8 7300000.0 0.09 1.46997692E8 4200000.0 0.07 0.1155 0.9928 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J02 mock treatment 1.52810893E8 2.03E7 0.25 1.66103801E8 2.33E7 0.4 0.4623 0.9766 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J03 mock treatment 1.15263179E8 -1.72E7 -0.22 1.58146972E8 1.53E7 0.26 0.0329 0.0968 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J04 mock treatment 1.1060413E8 -2.19E7 -0.27 1.65812647E8 2.3E7 0.39 0.0844 0.1758 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J05 mock treatment 1.33606284E8 1120000.0 0.01 1.72279988E8 2.95E7 0.5 0.3667 0.7264 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J06 mock treatment 1.63453838E8 3.1E7 0.39 1.51338357E8 8540000.0 0.15 0.378 0.9108 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J07 mock treatment 1.38851176E8 6360000.0 0.08 1.75219477E8 3.24E7 0.55 0.4488 0.8005 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J08 mock treatment 1.59826925E8 2.73E7 0.34 1.79848997E8 3.7E7 0.63 0.6909 0.9583 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J09 mock treatment 1.66932647E8 3.44E7 0.43 1.77485988E8 3.47E7 0.59 0.7253 0.9878 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J10 mock treatment 1.47220529E8 1.47E7 0.18 1.68167859E8 2.54E7 0.43 0.4377 0.9275 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J11 mock treatment 1.55681267E8 2.32E7 0.29 1.72525365E8 2.97E7 0.51 0.5655 0.9648 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J12 mock treatment 1.61445884E8 2.9E7 0.36 1.66470851E8 2.37E7 0.41 0.5433 0.9985 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J13 mock treatment 1.63997377E8 3.15E7 0.4 1.62351045E8 1.95E7 0.33 0.5161 0.9966 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J14 mock treatment 1.10996966E8 -2.15E7 -0.27 1.91865963E8 4.91E7 0.84 0.4032 0.4571 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J15 mock treatment 1.73171315E8 4.07E7 0.51 1.68871212E8 2.61E7 0.45 0.6764 0.9978 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J16 mock treatment 1.70010326E8 3.75E7 0.47 1.82216051E8 3.94E7 0.67 0.8099 0.9845 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J17 mock treatment 1.67089208E8 3.46E7 0.43 1.37606105E8 -5200000.0 -0.09 0.244 0.5508 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J18 mock treatment 1.70826312E8 3.83E7 0.48 1.66462843E8 2.37E7 0.41 0.6265 0.9964 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J19 mock treatment 1.75234356E8 4.27E7 0.54 1.50679641E8 7880000.0 0.13 0.4745 0.8582 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J20 mock treatment 1.40398547E8 7910000.0 0.1 1.68650675E8 2.58E7 0.44 0.383 0.8447 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J21 mock treatment 1.70380956E8 3.79E7 0.48 1.68340909E8 2.55E7 0.44 0.6452 0.9991 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J22 mock treatment 1.73449372E8 4.1E7 0.51 1.5634951E8 1.35E7 0.23 0.5273 0.9354 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J23 mock treatment 1.78309536E8 4.58E7 0.57 1.62833887E8 2.0E7 0.34 0.6489 0.9695 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 J24 mock treatment 1.68047465E8 3.56E7 0.45 1.50327165E8 7530000.0 0.13 0.4065 0.8756 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K01 compound treatment 1.33568265E8 1080000.0 0.01 1.22517627E8 -2.03E7 -0.35 -0.236 -0.6791 3065855 Maybridge4_004682 Oc1c/c(=N\c2ccc(Cl)cc2)/nc(COc3ccccc3)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K02 compound treatment 1.28082436E8 -4410000.0 -0.06 1.34558257E8 -8240000.0 -0.14 -0.1389 -0.9164 3179002 Maybridge4_004683 Cc1cc(nn1C(C)(C)C)C(=O)Sc2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K03 compound treatment 1.21208279E8 -1.13E7 -0.14 1.25922271E8 -1.69E7 -0.29 -0.3044 -0.9461 3179003 Maybridge4_004684 Cc1noc(COc2ccccc2)c1C(=O)Sc3ccc(F)cc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K04 compound treatment 1.29512213E8 -2980000.0 -0.04 1.43242347E8 441000.0 0.01 -0.0211 -0.553 3065857 Maybridge4_004685 Cc1c(C#N)c(Sc2cccc(c2)C(F)(F)F)nc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K05 compound treatment 1.44556685E8 1.21E7 0.15 1.53179725E8 1.04E7 0.18 0.2326 0.9968 3179004 Maybridge4_004686 CSc1nc(CSc2ccc(Cl)cc2)nc(C3CC3)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K06 compound treatment 1.46225943E8 1.37E7 0.17 1.45841461E8 3040000.0 0.05 0.1586 0.8814 3065858 Maybridge4_004687 Cc1cc(nn1Cc2c(Cl)cccc2Cl)C(=O)SCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K07 compound treatment 1.35106524E8 2620000.0 0.03 1.45291667E8 2490000.0 0.04 0.0533 0.9916 3179005 Maybridge4_004688 CCOC(=O)c1cc(C#N)c(Oc2ccc(C)cc2)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K08 compound treatment 1.50484227E8 1.8E7 0.23 1.54802033E8 1.2E7 0.21 0.3049 0.9989 3065859 Maybridge4_004689 CC(C)OC(=O)Nc1cc(Cl)cc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K09 compound treatment 1.61114772E8 2.86E7 0.36 1.02528158E8 -4.03E7 -0.69 -0.2336 -0.3005 3179006 Maybridge4_004690 FC(F)(F)C1CCN(CC1)c2ncccc2NC(=S)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K10 compound treatment 1.49470148E8 1.7E7 0.21 1.04281394E8 -3.85E7 -0.66 -0.3156 -0.4555 1235731 Maybridge4_004691 S=C(NC1CCCC1)N2CCCN(CC2)c3ccc(C#N)cn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K11 compound treatment 1.51914139E8 1.94E7 0.24 1.52443193E8 9640000.0 0.17 0.289 0.982 3179007 Maybridge4_004692 FC(F)(F)c1ccc(nc1)C(=N)NC(=O)c2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K12 compound treatment 1.48833359E8 1.63E7 0.21 1.57109566E8 1.43E7 0.24 0.3182 0.9961 1285775 Maybridge4_004693 Cc1onc(c1c2csc(CCn3c(=O)oc4ccccc34)n2)c5c(Cl)cccc5Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K13 compound treatment 1.56517801E8 2.4E7 0.3 1.8347873E8 4.07E7 0.7 0.7055 0.9298 3065861 Maybridge4_004694 NNC(=O)c1cccc(n1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K14 compound treatment 1.69382167E8 3.69E7 0.46 1.12096671E8 -3.07E7 -0.53 -0.0444 -0.0634 3179092 Maybridge4_004695 CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)NCCN3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K15 compound treatment 1.26766901E8 -5720000.0 -0.07 1.2571778E8 -1.71E7 -0.29 -0.2576 -0.8553 3065862 Maybridge4_004696 FC(F)(F)c1ccc(nc1)c2nnc(S)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K16 compound treatment 1.67583426E8 3.51E7 0.44 1.60592429E8 1.78E7 0.3 0.5266 0.9838 3065863 Maybridge4_004697 CC(C)N(CCC#N)C(=S)Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K17 compound treatment 1.56136063E8 2.36E7 0.3 1.49807532E8 7010000.0 0.12 0.2945 0.9206 3179093 Maybridge4_004698 CC(C)C(=N)NC(=S)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K18 compound treatment 1.83263018E8 5.08E7 0.64 1.50483424E8 7680000.0 0.13 0.5433 0.8355 1330597 Maybridge4_004699 CS(=O)(=O)c1ccc(cc1)C(=O)Nc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K19 compound treatment 1.78062175E8 4.56E7 0.57 1.51376537E8 8580000.0 0.15 0.508 0.8608 3179094 Maybridge4_004700 N=C(NC(=O)N1CCOCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K20 compound treatment 1.69454347E8 3.7E7 0.46 1.80206016E8 3.74E7 0.64 0.7806 0.9874 3065864 Maybridge4_004701 CN(C)/C=N/c1ncc(Br)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K21 compound treatment 1.63251076E8 3.08E7 0.39 1.46757869E8 3960000.0 0.07 0.3207 0.8187 3179095 Maybridge4_004702 CC(C)(C)C(=O)CSc1nnc(s1)c2cnccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K22 mock treatment 1.50259432E8 1.78E7 0.22 1.41246702E8 -1550000.0 -0.03 0.1388 0.6183 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K23 mock treatment 1.60038884E8 2.75E7 0.35 1.0409489E8 -3.87E7 -0.66 -0.2242 -0.3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 K24 mock treatment 1.44294999E8 1.18E7 0.15 1.33849068E8 -8950000.0 -0.15 -0.0037 -0.0172 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L01 mock treatment 1.38202287E8 5710000.0 0.07 8.296211E7 -5.98E7 -1.02 -0.6736 -0.656 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L02 mock treatment 1.23085373E8 -9410000.0 -0.12 9.8226961E7 -4.46E7 -0.76 -0.623 -0.8069 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L03 mock treatment 1.40406935E8 7920000.0 0.1 1.28708139E8 -1.41E7 -0.24 -0.1004 -0.3847 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L04 mock treatment 1.06035011E8 -2.65E7 -0.33 1.35766935E8 -7030000.0 -0.12 -0.3198 -0.9059 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L05 mock treatment 9.1514213E7 -4.1E7 -0.51 1.47572215E8 4770000.0 0.08 -0.3057 -0.5874 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L06 mock treatment 9.6899124E7 -3.56E7 -0.45 1.35530902E8 -7270000.0 -0.12 -0.4037 -0.871 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L07 mock treatment 8.0084405E7 -5.24E7 -0.66 1.36006001E8 -6800000.0 -0.12 -0.5471 -0.8195 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L08 mock treatment 8.1536509E7 -5.1E7 -0.64 1.39864001E8 -2940000.0 -0.05 -0.4875 -0.7604 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L09 mock treatment 8.1398369E7 -5.11E7 -0.64 1.54652945E8 1.19E7 0.2 -0.3098 -0.4608 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L10 mock treatment 1.2647848E8 -6010000.0 -0.08 9.3078456E7 -4.97E7 -0.85 -0.6552 -0.7668 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L11 mock treatment 9.7578982E7 -3.49E7 -0.44 1.41726841E8 -1070000.0 -0.02 -0.3227 -0.7362 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L12 mock treatment 1.21247793E8 -1.12E7 -0.14 1.3788388E8 -4920000.0 -0.08 -0.1593 -0.9696 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L13 mock treatment 8.0807236E7 -5.17E7 -0.65 1.25767314E8 -1.7E7 -0.29 -0.6646 -0.9349 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L14 mock treatment 7.7961587E7 -5.45E7 -0.68 9.6042928E7 -4.68E7 -0.8 -1.0497 -0.9969 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L15 mock treatment 7.190607E7 -6.06E7 -0.76 1.37271426E8 -5530000.0 -0.09 -0.6043 -0.7891 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L16 mock treatment 8.7996239E7 -4.45E7 -0.56 1.33281164E8 -9520000.0 -0.16 -0.5099 -0.8769 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L17 mock treatment 9.1933935E7 -4.06E7 -0.51 9.6592011E7 -4.62E7 -0.79 -0.9191 -0.9772 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L18 mock treatment 8.8566519E7 -4.39E7 -0.55 9.4655591E7 -4.81E7 -0.82 -0.9724 -0.9808 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L19 mock treatment 8.3961379E7 -4.85E7 -0.61 8.8797704E7 -5.4E7 -0.92 -1.0841 -0.9795 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L20 mock treatment 1.21894702E8 -1.06E7 -0.13 1.04876914E8 -3.79E7 -0.65 -0.553 -0.8346 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L21 mock treatment 1.0534687E8 -2.71E7 -0.34 1.52377176E8 9580000.0 0.16 -0.1249 -0.3304 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L22 mock treatment 1.44571858E8 1.21E7 0.15 1.27193482E8 -1.56E7 -0.27 -0.0818 -0.2662 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L23 mock treatment 1.20507321E8 -1.2E7 -0.15 1.36863051E8 -5940000.0 -0.1 -0.1782 -0.9818 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 L24 mock treatment 1.41631114E8 9140000.0 0.11 1.51991277E8 9190000.0 0.16 0.1923 0.9879 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M01 compound treatment 1.03837331E8 -2.87E7 -0.36 1.04326719E8 -3.85E7 -0.66 -0.7199 -0.9594 3065865 Maybridge4_004703 FC(F)(F)c1cccn(CCc2nc(cs2)c3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M02 compound treatment 1.06954608E8 -2.55E7 -0.32 1.1586401E8 -2.69E7 -0.46 -0.5526 -0.9842 3179096 Maybridge4_004704 Cc1cc(nn1C(C)(C)C)C(=O)Sc2cccc(Br)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M03 compound treatment 1.10989396E8 -2.15E7 -0.27 1.17454209E8 -2.53E7 -0.43 -0.4975 -0.9738 3179097 Maybridge4_004705 CN(CCOC(=O)c1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M04 compound treatment 1.11244226E8 -2.12E7 -0.27 1.23573111E8 -1.92E7 -0.33 -0.4212 -0.9945 3065866 Maybridge4_004706 Cc1c(C#N)c(Sc2n[nH]c(=O)n2C3CCCCC3)nc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M05 compound treatment 1.14538045E8 -1.8E7 -0.23 1.17300774E8 -2.55E7 -0.44 -0.4679 -0.9526 3065894 Maybridge4_004707 CCOC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)c3cccc(c3)C(F)(F)F)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M06 compound treatment 1.25246864E8 -7240000.0 -0.09 1.25156694E8 -1.76E7 -0.3 -0.2778 -0.8809 3065895 Maybridge4_004708 OC(C(O)c1nc2cc(C#N)ccc2[nH]1)c3nc4cc(C#N)ccc4[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M07 compound treatment 1.21650187E8 -1.08E7 -0.14 1.41588836E8 -1210000.0 -0.02 -0.1108 -0.8057 3065896 Maybridge4_004709 CCOC(=O)c1cc(C#N)c(Sc2nnc([nH]2)C(C)(C)C)nc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M08 compound treatment 1.19381943E8 -1.31E7 -0.16 1.16451114E8 -2.64E7 -0.45 -0.4352 -0.9065 3065897 Maybridge4_004710 NC(=S)Cc1ccc(Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M09 compound treatment 1.13232414E8 -1.93E7 -0.24 1.08644218E8 -3.42E7 -0.58 -0.5843 -0.9235 3065898 Maybridge4_004711 FC(F)(F)C1CCN(CC1)c2ncccc2NC(=S)Nc3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M10 compound treatment 1.27605911E8 -4890000.0 -0.06 1.15356269E8 -2.74E7 -0.47 -0.3755 -0.7926 1643927 Maybridge4_004712 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c2nnc(S)n2CC3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M11 compound treatment 1.21717963E8 -1.08E7 -0.14 1.27076551E8 -1.57E7 -0.27 -0.2859 -0.9492 3065900 Maybridge4_004713 FC(F)(F)c1ccc(=O)n(Cc2cccc(C#N)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M12 compound treatment 1.22915719E8 -9580000.0 -0.12 1.23098709E8 -1.97E7 -0.34 -0.3234 -0.9034 1263587 Maybridge4_004714 COc1ccccc1OCc2nc(cs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M13 compound treatment 1.25307492E8 -7180000.0 -0.09 1.17171828E8 -2.56E7 -0.44 -0.3739 -0.8349 3179098 Maybridge4_004715 FC(F)(F)c1ccc(cc1)C(=N)NC(=O)CCn2c(=O)oc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M14 compound treatment 1.2606854E8 -6420000.0 -0.08 1.37855009E8 -4950000.0 -0.08 -0.1168 -0.9997 1136340 Maybridge4_004716 CCOc1cc(N2CCOCC2)c(OCC)cc1NS(=O)(=O)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M15 compound treatment 1.3194323E8 -548000.0 -0.01 1.29703557E8 -1.31E7 -0.22 -0.1634 -0.7284 3179099 Maybridge4_004717 FC(F)(F)c1ccc(nc1)c2nnc(SCC=C)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M16 compound treatment 1.32210892E8 -280000.0 0.0 1.35861171E8 -6940000.0 -0.12 -0.0865 -0.7277 1122167 Maybridge4_004718 O=C(N1CCN(CCOc2ccccc2)CC1)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M17 compound treatment 1.30392727E8 -2100000.0 -0.03 1.15356184E8 -2.74E7 -0.47 -0.3508 -0.7456 3179100 Maybridge4_004719 FC(F)(F)COc1ccc(cn1)C(=O)NC(=N)c2ccc(cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M18 compound treatment 1.39626553E8 7140000.0 0.09 1.49219866E8 6420000.0 0.11 0.141 0.9948 3065901 Maybridge4_004720 CNC(=O)Nc1nc2cccnc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M19 compound treatment 1.27796559E8 -4690000.0 -0.06 1.44837384E8 2040000.0 0.03 -0.017 -0.2484 1030287 Maybridge4_004721 CSc1nc(O)cc(O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M20 compound treatment 1.33246525E8 755000.0 0.01 1.3502703E8 -7770000.0 -0.13 -0.0874 -0.6551 3179101 Maybridge4_004722 Cc1nc(N/C=N/O)c(Br)cc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M21 compound treatment 1.26380578E8 -6110000.0 -0.08 5.9702508E7 -8.31E7 -1.42 -1.06 -0.7441 3179102 Maybridge4_004723 Cc1nc(c(s1)C(=O)Sc2ccc(C)cc2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M22 mock treatment 1.24489304E8 -8000000.0 -0.1 9.2683239E7 -5.01E7 -0.86 -0.6776 -0.7845 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M23 mock treatment 1.26944898E8 -5550000.0 -0.07 9.3061388E7 -4.97E7 -0.85 -0.6513 -0.7623 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 M24 mock treatment 1.19434514E8 -1.31E7 -0.16 1.22463672E8 -2.03E7 -0.35 -0.362 -0.9409 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N01 mock treatment 1.19246885E8 -1.32E7 -0.17 1.33299592E8 -9500000.0 -0.16 -0.2325 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N02 mock treatment 1.13994402E8 -1.85E7 -0.23 1.38884951E8 -3920000.0 -0.07 -0.2115 -0.8756 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N03 mock treatment 1.19705245E8 -1.28E7 -0.16 1.40947486E8 -1850000.0 -0.03 -0.1359 -0.8309 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N04 mock treatment 1.29500945E8 -2990000.0 -0.04 1.3137313E8 -1.14E7 -0.2 -0.1649 -0.8276 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N05 mock treatment 1.31908477E8 -583000.0 -0.01 1.4298965E8 188000.0 0.0 -0.0029 -0.3614 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N06 mock treatment 1.1413996E8 -1.84E7 -0.23 1.43172648E8 371000.0 0.01 -0.1583 -0.6873 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N07 mock treatment 7.602908E7 -5.65E7 -0.71 1.35639313E8 -7160000.0 -0.12 -0.5875 -0.8173 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N08 mock treatment 1.123481E8 -2.01E7 -0.25 1.28392085E8 -1.44E7 -0.25 -0.3531 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N09 mock treatment 1.22377401E8 -1.01E7 -0.13 1.35522685E8 -7280000.0 -0.12 -0.1778 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N10 mock treatment 1.32467267E8 -24000.0 0.0 1.24134487E8 -1.87E7 -0.32 -0.2262 -0.7078 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N11 mock treatment 1.27520132E8 -4970000.0 -0.06 7.6731246E7 -6.61E7 -1.13 -0.8438 -0.745 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N12 mock treatment 1.1655439E8 -1.59E7 -0.2 1.23509021E8 -1.93E7 -0.33 -0.3749 -0.9711 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N13 mock treatment 1.20508438E8 -1.2E7 -0.15 1.2051089E8 -2.23E7 -0.38 -0.3761 -0.9171 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N14 mock treatment 1.20289504E8 -1.22E7 -0.15 1.28662039E8 -1.41E7 -0.24 -0.2794 -0.9756 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N15 mock treatment 1.40216746E8 7730000.0 0.1 1.20898864E8 -2.19E7 -0.37 -0.1966 -0.5076 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N16 mock treatment 1.42401909E8 9910000.0 0.12 8.1276118E7 -6.15E7 -1.05 -0.6568 -0.6193 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N17 mock treatment 1.39179308E8 6690000.0 0.08 1.38655736E8 -4150000.0 -0.07 0.0091 0.0833 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N18 mock treatment 1.33681039E8 1190000.0 0.01 1.45087346E8 2290000.0 0.04 0.0382 0.9127 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N19 mock treatment 1.34157589E8 1670000.0 0.02 1.29210448E8 -1.36E7 -0.23 -0.1497 -0.641 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N20 mock treatment 1.39891512E8 7400000.0 0.09 1.34425448E8 -8380000.0 -0.14 -0.0357 -0.2092 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N21 mock treatment 1.20363333E8 -1.21E7 -0.15 1.27058175E8 -1.57E7 -0.27 -0.2981 -0.9634 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N22 mock treatment 1.38172357E8 5680000.0 0.07 1.38184472E8 -4620000.0 -0.08 -0.0055 -0.0516 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N23 mock treatment 1.27949728E8 -4540000.0 -0.06 1.30445968E8 -1.24E7 -0.21 -0.1898 -0.8667 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 N24 mock treatment 1.18076745E8 -1.44E7 -0.18 1.13365309E8 -2.94E7 -0.5 -0.4842 -0.9044 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O01 compound treatment 1.20159268E8 -1.23E7 -0.15 1.08268129E8 -3.45E7 -0.59 -0.5274 -0.8631 3065902 Maybridge4_004724 Cc1nn(c(N)c1C(=S)N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O02 compound treatment 9.7729599E7 -3.48E7 -0.44 1.00620888E8 -4.22E7 -0.72 -0.8189 -0.9708 1470895 Maybridge4_004725 CCOC(=O)c1cc(Sc2ccccc2NC(=O)c3ccccc3)cc(n1)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O03 compound treatment 1.05623645E8 -2.69E7 -0.34 1.14609725E8 -2.82E7 -0.48 -0.5796 -0.9846 3065903 Maybridge4_004726 Cc1cc(no1)c2nnc(SCC(=O)c3ccccc3Cl)n2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O04 compound treatment 1.08353449E8 -2.41E7 -0.3 6.8046447E7 -7.48E7 -1.28 -1.119 -0.8509 1417512 Maybridge4_004727 Cc1c(C#N)c(Sc2ccccc2NC(=O)c3ccccc3)nc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O05 compound treatment 1.13760489E8 -1.87E7 -0.23 1.20521578E8 -2.23E7 -0.38 -0.4358 -0.9729 3065905 Maybridge4_004728 CC(C)(C)c1ccc(OCC(=N)NC(=O)c2ccc(OC(F)(F)F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O06 compound treatment 1.3698488E8 4490000.0 0.06 1.41585016E8 -1220000.0 -0.02 0.0251 0.4183 1176898 Maybridge4_004729 OC(C(O)c1nc2cc(Cl)ccc2[nH]1)c3nc4cc(Cl)ccc4[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O07 compound treatment 1.17805713E8 -1.47E7 -0.18 1.2203419E8 -2.08E7 -0.36 -0.3816 -0.9532 3065906 Maybridge4_004730 Cc1nc(nc(Sc2nnc([nH]2)c3cccs3)c1C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O08 compound treatment 1.16672587E8 -1.58E7 -0.2 1.16075171E8 -2.67E7 -0.46 -0.4638 -0.9301 3179103 Maybridge4_004731 CC(=O)N/C(=C\c1ccc2ccccc2c1)/C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O09 compound treatment 1.15974884E8 -1.65E7 -0.21 1.107489E8 -3.21E7 -0.55 -0.5345 -0.9113 3179104 Maybridge4_004732 NC(=O)C1=CN(Cc2ccccc2)CCC1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O10 compound treatment 1.13146622E8 -1.93E7 -0.24 1.13570916E8 -2.92E7 -0.5 -0.5254 -0.9448 3065908 Maybridge4_004733 CC(C)(C)c1cc(c2nnc(o2)c3cccs3)n(Cc4ccc(F)cc4)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O11 compound treatment 1.25783148E8 -6710000.0 -0.08 1.11843003E8 -3.1E7 -0.53 -0.4342 -0.8093 3179105 Maybridge4_004734 FC(F)(F)COc1cc(cc(OCC(F)(F)F)n1)c2nnc(S)n2Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O12 compound treatment 1.16738837E8 -1.58E7 -0.2 1.12753965E8 -3.0E7 -0.51 -0.5034 -0.9137 3065960 Maybridge4_004735 Clc1ccc(Sc2c[nH]nc2c3ccc4OCCOc4c3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O13 compound treatment 1.24480318E8 -8010000.0 -0.1 1.08772871E8 -3.4E7 -0.58 -0.4829 -0.817 1741446 Maybridge4_004736 CC(C)(C)NC(=O)N1CCN(CC1)c2ccc(C#N)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O14 compound treatment 1.17080219E8 -1.54E7 -0.19 1.16559351E8 -2.62E7 -0.45 -0.4543 -0.929 1571449 Maybridge4_004737 CCOc1cc(N2CCOCC2)c(OCC)cc1NC(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O15 compound treatment 1.27882856E8 -4610000.0 -0.06 1.2077201E8 -2.2E7 -0.38 -0.3075 -0.8061 3065932 Maybridge4_004738 N/C(=N\O)/c1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O16 compound treatment 1.07886942E8 -2.46E7 -0.31 9.7344606E7 -4.55E7 -0.78 -0.7685 -0.918 1468379 Maybridge4_004739 CC(C)c1ccc(NC(=O)N2CCCN(CCOc3ccccc3)CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O17 compound treatment 1.09092112E8 -2.34E7 -0.29 9.7737856E7 -4.51E7 -0.77 -0.753 -0.9124 3065933 Maybridge4_004740 COc1ccc(OCC(=N)NC(=S)Nc2cccc(c2)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O18 compound treatment 1.20342847E8 -1.21E7 -0.15 1.02879151E8 -3.99E7 -0.68 -0.591 -0.8441 3065934 Maybridge4_004741 NC(=C(C#N)C#N)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O19 compound treatment 1.13840116E8 -1.87E7 -0.23 1.09065963E8 -3.37E7 -0.58 -0.5738 -0.9209 3065935 Maybridge4_004742 Oc1nnc(SCC(=O)N2CCC(CC2)C(F)(F)F)n1c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O20 compound treatment 1.25999724E8 -6490000.0 -0.08 1.11364062E8 -3.14E7 -0.54 -0.4381 -0.8049 3065936 Maybridge4_004743 Cc1cc(Br)cnc1N/C=N/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O21 compound treatment 1.11149614E8 -2.13E7 -0.27 9.5273836E7 -4.75E7 -0.81 -0.7646 -0.8927 3179106 Maybridge4_004744 Cc1nc(c(s1)C(=O)Sc2cccc(c2)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O22 mock treatment 1.12864632E8 -1.96E7 -0.25 1.05043036E8 -3.78E7 -0.65 -0.6311 -0.9125 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O23 mock treatment 1.19717997E8 -1.28E7 -0.16 1.02506768E8 -4.03E7 -0.69 -0.601 -0.8488 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 O24 mock treatment 1.16670336E8 -1.58E7 -0.2 1.08743884E8 -3.41E7 -0.58 -0.5526 -0.8973 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P01 mock treatment 1.17570649E8 -1.49E7 -0.19 5.0972738E7 -9.18E7 -1.57 -1.2439 -0.7858 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P02 mock treatment 1.10366369E8 -2.21E7 -0.28 1.12440146E8 -3.04E7 -0.52 -0.5638 -0.9568 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P03 mock treatment 1.15143033E8 -1.73E7 -0.22 1.11757059E8 -3.1E7 -0.53 -0.5296 -0.9223 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P04 mock treatment 1.08154892E8 -2.43E7 -0.31 1.13601081E8 -2.92E7 -0.5 -0.5693 -0.972 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P05 mock treatment 1.09443473E8 -2.3E7 -0.29 1.10510041E8 -3.23E7 -0.55 -0.5953 -0.9543 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P06 mock treatment 1.09550681E8 -2.29E7 -0.29 1.02166836E8 -4.06E7 -0.7 -0.6953 -0.9237 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P07 mock treatment 1.13104014E8 -1.94E7 -0.24 1.09216198E8 -3.36E7 -0.57 -0.5785 -0.9267 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P08 mock treatment 1.10493079E8 -2.2E7 -0.28 1.1333829E8 -2.95E7 -0.5 -0.5518 -0.9597 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P09 mock treatment 1.12702938E8 -1.98E7 -0.25 1.12157462E8 -3.06E7 -0.52 -0.5464 -0.9416 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P10 mock treatment 1.07745205E8 -2.47E7 -0.31 1.07373047E8 -3.54E7 -0.61 -0.6483 -0.9516 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P11 mock treatment 1.06997748E8 -2.55E7 -0.32 1.13248142E8 -2.96E7 -0.51 -0.5839 -0.9755 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P12 mock treatment 1.06089229E8 -2.64E7 -0.33 1.05445017E8 -3.74E7 -0.64 -0.6864 -0.9531 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P13 mock treatment 1.01460807E8 -3.1E7 -0.39 1.01031859E8 -4.18E7 -0.72 -0.7808 -0.9591 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P14 mock treatment 1.02457324E8 -3.0E7 -0.38 1.10029138E8 -3.28E7 -0.56 -0.6631 -0.9812 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P15 mock treatment 1.18011252E8 -1.45E7 -0.18 1.04053641E8 -3.87E7 -0.66 -0.5975 -0.8688 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P16 mock treatment 1.07234142E8 -2.53E7 -0.32 1.16281096E8 -2.65E7 -0.45 -0.545 -0.9845 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P17 mock treatment 1.15932331E8 -1.66E7 -0.21 1.13841349E8 -2.9E7 -0.5 -0.4974 -0.9254 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P18 mock treatment 1.09988443E8 -2.25E7 -0.28 1.16854213E8 -2.59E7 -0.44 -0.5137 -0.9761 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P19 mock treatment 1.12759829E8 -1.97E7 -0.25 1.14221072E8 -2.86E7 -0.49 -0.521 -0.9502 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P20 mock treatment 1.18097149E8 -1.44E7 -0.18 1.076959E8 -3.51E7 -0.6 -0.5526 -0.8807 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P21 mock treatment 1.12854873E8 -1.96E7 -0.25 1.07031518E8 -3.58E7 -0.61 -0.6071 -0.9199 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P22 mock treatment 1.07091387E8 -2.54E7 -0.32 1.12267679E8 -3.05E7 -0.52 -0.5949 -0.9718 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P23 mock treatment 1.1464627E8 -1.78E7 -0.22 1.01720758E8 -4.11E7 -0.7 -0.6555 -0.8883 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2062 P24 mock treatment 1.14323733E8 -1.82E7 -0.23 1.12472555E8 -3.03E7 -0.52 -0.5283 -0.9317 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A01 compound treatment 5.6082025E7 -7.32E7 -0.92 1.15247704E8 -1.73E7 -0.3 -0.8583 -0.8901 1360118 TimTec1_000001 CC1=C(C(C2=C(CC(CC2=O)c3ccccc3)N1)c4ccncc4)C(=O)OC5CCCC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A02 compound treatment 4.8553989E7 -8.07E7 -1.01 1.13356684E8 -1.92E7 -0.33 -0.948 -0.8908 1352805 TimTec1_000002 CCOC(=O)c1cc2ccccc2oc1=N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A03 compound treatment 5.7494061E7 -7.17E7 -0.9 1.24550845E8 -7990000.0 -0.14 -0.7332 -0.8054 1269647 TimTec1_000003 CN1C2CCC1CC(C2)NC3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A04 compound treatment 9.342004E7 -3.58E7 -0.45 1.27724486E8 -4820000.0 -0.08 -0.3761 -0.8232 1717432 TimTec1_000004 NC1=C(C#N)C2=C(CCCC2)C(c3ccccc3)C1(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A05 compound treatment 1.27356545E8 -1880000.0 -0.02 1.41309538E8 8760000.0 0.15 0.0894 0.5884 1640292 TimTec1_000005 CC1C2CC(C(C2=O)S(=O)(=O)N3CCOCC3)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A06 compound treatment 1.38006699E8 8770000.0 0.11 1.33500097E8 954000.0 0.02 0.0893 0.8033 1432692 TimTec1_000006 CC(=C)C[N+](C)(C)Cc1c(C)ccc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A07 compound treatment 1.41643765E8 1.24E7 0.16 1.38583878E8 6040000.0 0.1 0.1831 0.9803 3209477 TimTec1_000007 O=C1N(CSc2nc3ccccc3s2)C(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A08 compound treatment 1.3916953E8 9930000.0 0.12 1.38386754E8 5840000.0 0.1 0.1588 0.9941 1665724 TimTec1_000008 CC1(C)CC(=C(C(C2C(=O)CC(C)(C)CC2=O)c3ccccc3)C(=O)C1)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A09 compound treatment 1.37837704E8 8600000.0 0.11 1.42841824E8 1.03E7 0.18 0.2009 0.9722 1568897 TimTec1_000009 CCOC(=O)c1ccc(NC(=O)NC2OC(CO)C(O)C(O)C2O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A10 compound treatment 1.36687049E8 7450000.0 0.09 1.58341448E8 2.58E7 0.44 0.3783 0.8381 3082080 TimTec1_000010 Cc1cc[n+](Cc2ccccn2)c(N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A11 compound treatment 1.02835154E8 -2.64E7 -0.33 1.07751616E8 -2.48E7 -0.42 -0.5343 -0.9925 1782663 TimTec1_000011 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3NC2/C=C/c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A12 compound treatment 1.30682851E8 1440000.0 0.02 1.49577678E8 1.7E7 0.29 0.2189 0.7495 3082082 TimTec1_000012 CCCC1CCCCCC1NC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A13 compound treatment 1.26867361E8 -2370000.0 -0.03 1.35144478E8 2600000.0 0.04 0.0104 0.1942 3508726 TimTec1_000013 CCC(=O)NC1CC(CC=C1C)C(C)(C)NC(=O)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A14 compound treatment 1.27399687E8 -1840000.0 -0.02 1.37453958E8 4910000.0 0.08 0.0431 0.4943 3209587 TimTec1_000014 OC(=O)CCC(=O)N=S(c1ccccc1)c2ccccc2.Oc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A15 compound treatment 1.46846782E8 1.76E7 0.22 1.59323354E8 2.68E7 0.46 0.4803 0.9439 1459520 TimTec1_000015 COc1ccccc1c2nnc(N)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A16 compound treatment 1.35960766E8 6720000.0 0.08 1.35793464E8 3250000.0 0.06 0.0989 0.9796 3082084 TimTec1_000016 Cc1[nH]c2ccccc2c1Sc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A17 compound treatment 1.36302618E8 7060000.0 0.09 1.56472989E8 2.39E7 0.41 0.3523 0.8406 1172294 TimTec1_000017 Cc1cc(C)c(NC(=O)CCNC2CCCCC2)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A18 compound treatment 1.18622928E8 -1.06E7 -0.13 1.259794E8 -6570000.0 -0.11 -0.1737 -0.9964 1183562 TimTec1_000018 CCOC(=O)c1c(CN2CCOCC2)n(c3ccccc3)c4ccc(O)cc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A19 compound treatment 1.30434069E8 1190000.0 0.01 1.3179929E8 -747000.0 -0.01 0.0015 0.0785 1230606 TimTec1_000019 CCN1CCN(CC1)c2ccc(NC(=O)c3cccc(Br)c3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A20 compound treatment 1.32687406E8 3450000.0 0.04 1.52233712E8 1.97E7 0.34 0.2689 0.7913 1045901 TimTec1_000020 COC(=O)c1cc2ccccc2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A21 compound treatment 1.36981232E8 7740000.0 0.1 1.54995407E8 2.24E7 0.38 0.3404 0.8588 3209588 TimTec1_000021 CSc1ccc(/C=N/n2nnnc2Nc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A22 compound treatment 1.03999326E8 -2.52E7 -0.32 1.14440435E8 -1.81E7 -0.31 -0.4431 -0.9999 3082088 TimTec1_000022 OC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A23 mock treatment 1.43545155E8 1.43E7 0.18 1.36981049E8 4440000.0 0.08 0.1806 0.9268 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 A24 mock treatment 1.36250658E8 7010000.0 0.09 1.35889448E8 3340000.0 0.06 0.1026 0.9784 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B01 compound treatment 1.41523951E8 1.23E7 0.15 1.41340039E8 8790000.0 0.15 0.2154 0.9999 1462495 TimTec1_000023 CSc1c(CC(=O)Nc2ccccc2)n(C)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B02 compound treatment 9.4895749E7 -3.43E7 -0.43 1.00109455E8 -3.24E7 -0.56 -0.6973 -0.9921 3209589 TimTec1_000024 Nc1c(sc2nc(N)c(C#N)cc12)C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B03 compound treatment 1.58383941E8 2.91E7 0.37 1.39554031E8 7010000.0 0.12 0.3433 0.8923 1291339 TimTec1_000025 CCOC(=O)c1c(CN2CCOCC2)n(C)c3ccc(O)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B04 compound treatment 1.5509193E8 2.59E7 0.32 1.61266743E8 2.87E7 0.49 0.5769 0.9796 1292419 TimTec1_000026 O=C(Oc1ccc(OC(=O)c2ccco2)cc1)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B05 compound treatment 1.57841094E8 2.86E7 0.36 1.5050184E8 1.8E7 0.31 0.471 0.997 1346277 TimTec1_000027 O=C(N1CCCCC1)c2ccc(cc2)C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B06 compound treatment 1.44039734E8 1.48E7 0.19 1.37448432E8 4900000.0 0.08 0.1906 0.9356 1037513 TimTec1_000028 O=C1N(C(=O)c2ccccc12)c3nccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B07 compound treatment 1.45685991E8 1.64E7 0.21 1.54562718E8 2.2E7 0.38 0.4124 0.9598 3209590 TimTec1_000029 Cc1ccc(s1)C(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B08 compound treatment 1.52263118E8 2.3E7 0.29 9.4520861E7 -3.8E7 -0.65 -0.2561 -0.3596 1598558 TimTec1_000030 O=C(Nc1ccccc1)C(=S)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B09 compound treatment 1.47946558E8 1.87E7 0.23 1.39183573E8 6640000.0 0.11 0.2463 0.9446 1166367 TimTec1_000031 CCOC(=O)c1c(CN2CCCCC2)n(c3ccccc3)c4cc(Br)c(OC)cc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B10 compound treatment 1.41779436E8 1.25E7 0.16 8.5343737E7 -4.72E7 -0.81 -0.4601 -0.559 3081103 TimTec1_000032 C/C(=N\C1CC1)/c2c(C)[nH]n(c3nc4ccccc4s3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B11 compound treatment 1.3882763E8 9590000.0 0.12 9.1931698E7 -4.06E7 -0.7 -0.4066 -0.5762 1692568 TimTec1_000033 Fc1ccc(cc1)C(=O)CCCN2CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B12 compound treatment 1.25548028E8 -3690000.0 -0.05 9.8998244E7 -3.35E7 -0.57 -0.4388 -0.7617 3209591 TimTec1_000034 CCN1C(=O)/C(=C\2/C=Cc3ccccc3N2CC)/N(C)C1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B13 compound treatment 1.40357072E8 1.11E7 0.14 1.35044328E8 2500000.0 0.04 0.1288 0.8834 1611433 TimTec1_000035 CC(=O)Oc1ccc2occ(C(=O)c3ccc(Br)s3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B14 compound treatment 1.46508905E8 1.73E7 0.22 1.49517545E8 1.7E7 0.29 0.3586 0.9895 1351179 TimTec1_000036 O=C(c1nnn(c1Nc2ccccc2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B15 compound treatment 1.47820634E8 1.86E7 0.23 1.41380961E8 8840000.0 0.15 0.2717 0.9781 1357665 TimTec1_000037 OC(=O)c1cccc(CN2CCN(CC2)c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B16 compound treatment 1.20627651E8 -8610000.0 -0.11 1.41365272E8 8820000.0 0.15 0.0303 0.1635 1209399 TimTec1_000038 O=C(NCCc1ccccc1)c2ccc(cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B17 compound treatment 1.53768929E8 2.45E7 0.31 8.8145818E7 -4.44E7 -0.76 -0.3199 -0.3901 3209592 TimTec1_000039 CNC(=O)CSCc1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B18 compound treatment 1.33755993E8 4510000.0 0.06 1.32971019E8 425000.0 0.01 0.0452 0.7915 3209593 TimTec1_000040 O=C(Oc1nc2ccccc2s1)/C=C/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B19 compound treatment 1.36074073E8 6830000.0 0.09 1.37906336E8 5360000.0 0.09 0.1255 0.9994 1421610 TimTec1_000041 CN(C(=O)Oc1cccc(c1)C(=O)Nc2ccc(C)c(C)c2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B20 compound treatment 1.5868555E8 2.94E7 0.37 1.42686499E8 1.01E7 0.17 0.3839 0.9407 3209594 TimTec1_000042 COC(=O)NC(Nc1cccc(c1)C(F)(F)F)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B21 compound treatment 1.71273555E8 4.2E7 0.53 1.70359396E8 3.78E7 0.65 0.8305 0.9948 1920491 TimTec1_000043 COc1ccc2nc(NC(=N)N)nc(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B22 compound treatment 1.420065E8 1.28E7 0.16 1.21693E8 -1.09E7 -0.19 -0.0181 -0.0739 1644751 TimTec1_000044 COc1ccc(cc1)C(=O)Oc2csc(=S)n2C(=O)c3ccc(OC)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B23 mock treatment 1.35258704E8 6020000.0 0.08 1.02108804E8 -3.04E7 -0.52 -0.315 -0.5984 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 B24 mock treatment 1.41945622E8 1.27E7 0.16 1.39316977E8 6770000.0 0.12 0.1947 0.9878 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C01 compound treatment 3.3869401E7 -9.54E7 -1.2 9.666284E7 -3.59E7 -0.61 -1.2803 -0.952 1157703 TimTec1_000045 COc1ccc2C3CC(=Nc4ccccc4N3C(=O)c2c1OC)c5ccc(Br)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C02 compound treatment 5.0991147E7 -7.83E7 -0.98 1.03789341E8 -2.88E7 -0.49 -1.0422 -0.9491 3209595 TimTec1_000046 COC(=O)CC1=CC(C)(CC(=O)OC)C(C#N)(C#N)C(=C1C#N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C03 compound treatment 6.5659268E7 -6.36E7 -0.8 1.32792779E8 247000.0 0.0 -0.561 -0.7033 1704164 TimTec1_000047 CCCCN(C1CC2CCC(C1)N2C)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C04 compound treatment 8.5486186E7 -4.38E7 -0.55 1.1338108E8 -1.92E7 -0.33 -0.6201 -0.9697 1258841 TimTec1_000048 O=C1C(=C2CCCCC2C(c3ccco3)C1(C#N)C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C05 compound treatment 1.22986957E8 -6250000.0 -0.08 1.33280131E8 734000.0 0.01 -0.0466 -0.5863 1916777 TimTec1_000049 CC1C/2CC(C(\C2=N\O)S(=O)(=O)N3CCOCC3)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C06 compound treatment 1.22127677E8 -7110000.0 -0.09 1.37166431E8 4620000.0 0.08 -0.0072 -0.0601 3209596 TimTec1_000050 COC1OC(COC(=O)C)C(OC(=O)C)C(C#N)(C#N)C1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C07 compound treatment 1.31429523E8 2190000.0 0.03 1.33828023E8 1280000.0 0.02 0.0349 0.9939 1250478 TimTec1_000051 OC(COc1ccc(Nc2ccccc2)cc1)COc3ccc(Nc4ccccc4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C08 compound treatment 1.2823548E8 -1010000.0 -0.01 1.39922655E8 7380000.0 0.13 0.0804 0.6333 1606069 TimTec1_000052 CC(C)C(C1C(=O)CC(C)(C)CC1=O)C2=C(O)CC(C)(C)CC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C09 compound treatment 1.15424992E8 -1.38E7 -0.17 1.43622276E8 1.11E7 0.19 0.0115 0.0448 3081440 TimTec1_000053 CCNC(=O)c1ccc(Cl)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C10 compound treatment 1.15449501E8 -1.38E7 -0.17 1.35506606E8 2960000.0 0.05 -0.0865 -0.4798 3209597 TimTec1_000054 Cc1cc[n+](CCOc2ccc(N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C11 compound treatment 1.0470235E8 -2.45E7 -0.31 1.29303257E8 -3240000.0 -0.06 -0.2569 -0.8214 1677737 TimTec1_000055 CCCCC(=O)N1C(C)CC(Nc2ccccc2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C12 compound treatment 1.02088688E8 -2.72E7 -0.34 1.32870205E8 324000.0 0.01 -0.2369 -0.6955 3081441 TimTec1_000056 CCOC(=O)CCCc1ccc(/C=C/C(=O)O)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C13 compound treatment 1.0112674E8 -2.81E7 -0.35 1.33692068E8 1150000.0 0.02 -0.2355 -0.6667 3081442 TimTec1_000057 COC(=O)c1nsc(Cl)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C14 compound treatment 1.02174498E8 -2.71E7 -0.34 1.34151171E8 1610000.0 0.03 -0.2207 -0.6478 1003566 TimTec1_000058 S=C(Nc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C15 compound treatment 1.05946259E8 -2.33E7 -0.29 1.31647999E8 -898000.0 -0.02 -0.2175 -0.7433 1060631 TimTec1_000059 COC(=O)C1=NNC(C1)(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C16 compound treatment 1.11753583E8 -1.75E7 -0.22 1.37600572E8 5050000.0 0.09 -0.0939 -0.3983 3081443 TimTec1_000060 CN(C)/C=C(\C=[N+](C)C)/c1n[nH]cc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C17 compound treatment 1.12640217E8 -1.66E7 -0.21 1.3718477E8 4640000.0 0.08 -0.0911 -0.4088 1149044 TimTec1_000061 Cc1cc(Cl)c(C(=O)N)c(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C18 compound treatment 1.08793432E8 -2.04E7 -0.26 1.34358557E8 1810000.0 0.03 -0.1594 -0.6171 1602135 TimTec1_000062 CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccncc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C19 compound treatment 1.08672679E8 -2.06E7 -0.26 1.40379893E8 7830000.0 0.13 -0.0876 -0.3013 3081444 TimTec1_000063 CCN1CCN(CC1)c2ccc(NC(=O)/C=C/c3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C20 compound treatment 1.08977866E8 -2.03E7 -0.25 1.37474072E8 4930000.0 0.08 -0.1201 -0.4484 1241763 TimTec1_000064 Oc1ccc2occ(C(=O)c3cccs3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C21 compound treatment 1.09488013E8 -1.98E7 -0.25 1.28317102E8 -4230000.0 -0.07 -0.2264 -0.877 3081445 TimTec1_000065 Nc1nnnn1/N=C\2/C(=O)Nc3ccc(Br)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C22 compound treatment 1.09872854E8 -1.94E7 -0.24 1.30942011E8 -1600000.0 -0.03 -0.1912 -0.782 1336111 TimTec1_000066 COC(=O)CCc1[nH]c2ccccc2c1Sc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C23 mock treatment 1.19827115E8 -9410000.0 -0.12 1.33618435E8 1070000.0 0.02 -0.0705 -0.5901 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 C24 mock treatment 1.16842341E8 -1.24E7 -0.16 1.48904652E8 1.64E7 0.28 0.088 0.2748 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D01 compound treatment 1.21945002E8 -7300000.0 -0.09 1.24238409E8 -8310000.0 -0.14 -0.1653 -0.9773 1420975 TimTec1_000067 CSc1c(CC(=O)Nc2ccc(C)cc2)[nH]c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D02 compound treatment 1.30324841E8 1080000.0 0.01 1.28417068E8 -4130000.0 -0.07 -0.0404 -0.5608 3209598 TimTec1_000068 OC(=O)CCCC=C(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D03 compound treatment 1.51981934E8 2.27E7 0.29 8.7157483E7 -4.54E7 -0.78 -0.3477 -0.4201 3209599 TimTec1_000069 Cc1[nH]c2ccccc2c1/C=N/CCc3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D04 compound treatment 1.40783259E8 1.15E7 0.14 1.33376067E8 830000.0 0.01 0.1124 0.7728 3081446 TimTec1_000070 Brc1ccc(OC(=O)c2ccco2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D05 compound treatment 1.37294488E8 8050000.0 0.1 1.20777788E8 -1.18E7 -0.2 -0.071 -0.3151 3081447 TimTec1_000071 CCC(=O)n1c(SC)nc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D06 compound treatment 1.22932678E8 -6310000.0 -0.08 9.5454355E7 -3.71E7 -0.63 -0.5049 -0.7891 3209600 TimTec1_000072 Nc1nc(SCC(=O)NC2CCCCC2)c(C#N)cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D07 compound treatment 1.3976922E8 1.05E7 0.13 1.39379402E8 6830000.0 0.12 0.1761 0.9982 3081448 TimTec1_000073 CCCc1ccc(s1)/C(=N/O)/C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D08 compound treatment 1.18597265E8 -1.06E7 -0.13 6.5464236E7 -6.71E7 -1.15 -0.9064 -0.784 3209601 TimTec1_000074 CCOC(=O)CCSc1ccccn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D09 compound treatment 1.24948834E8 -4290000.0 -0.05 9.2764256E7 -3.98E7 -0.68 -0.5196 -0.7606 1380002 TimTec1_000075 CCOC(=O)c1c(CN(C)C)n(c2ccccc2)c3cc(Br)c(OC)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D10 compound treatment 1.30794449E8 1550000.0 0.02 1.19905585E8 -1.26E7 -0.22 -0.1392 -0.6408 3081452 TimTec1_000076 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3N(C2c4ccc(Cl)cc4Cl)C(=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D11 compound treatment 1.36164382E8 6920000.0 0.09 1.22021562E8 -1.05E7 -0.18 -0.066 -0.3299 1674072 TimTec1_000077 Cn1c(CC(=O)O)c(c2ccccc12)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D12 compound treatment 1.22478734E8 -6760000.0 -0.08 1.16691425E8 -1.59E7 -0.27 -0.2519 -0.8859 1452087 TimTec1_000078 CCSc1nnc-2c(OC(Nc3ccccc32)C(=O)c4ccccc4)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D13 compound treatment 1.26237596E8 -3000000.0 -0.04 1.21842432E8 -1.07E7 -0.18 -0.1562 -0.8351 1648799 TimTec1_000079 C(CN1CCN(CCSc2ccccc2)CC1)Sc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D14 compound treatment 1.54078563E8 2.48E7 0.31 1.55816643E8 2.33E7 0.4 0.502 0.9926 1276972 TimTec1_000080 Clc1ccccc1CN(Cc2cccnc2)C(=S)NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D15 compound treatment 1.09102879E8 -2.01E7 -0.25 1.1353517E8 -1.9E7 -0.33 -0.4087 -0.9922 1186617 TimTec1_000081 Cc1c([nH]c2ccc(OCc3ccccc3)cc12)C(=O)N4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D16 compound treatment 1.2804836E8 -1190000.0 -0.01 1.26781452E8 -5760000.0 -0.1 -0.0804 -0.8051 1357113 TimTec1_000082 CC1Oc2ccccc2OC1(O)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D17 compound treatment 1.34522178E8 5280000.0 0.07 1.32125128E8 -421000.0 -0.01 0.0418 0.6266 3081458 TimTec1_000083 Brc1ccccc1NCn2nc(oc2=S)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D18 compound treatment 1.28851203E8 -390000.0 0.0 1.39570921E8 7030000.0 0.12 0.0816 0.6778 3209728 TimTec1_000084 Fc1ccccc1OC(=O)N2c3ccccc3Sc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D19 compound treatment 1.34358615E8 5120000.0 0.06 1.3082041E8 -1730000.0 -0.03 0.0245 0.3468 1270584 TimTec1_000085 Cc1ccc(cc1)S(=O)(=O)N2c3ccccc3C(C)(CC2(C)C)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D20 compound treatment 1.29371697E8 130000.0 0.0 1.34501335E8 1960000.0 0.03 0.0248 0.7408 3081461 TimTec1_000086 FC(F)(F)c1cccc(c1)c2ccc(/C=N\C3CCS(=O)(=O)C3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D21 compound treatment 1.15695916E8 -1.35E7 -0.17 1.20240866E8 -1.23E7 -0.21 -0.2691 -0.9943 1450123 TimTec1_000087 CCOC(=O)c1c(C)n(c2cccc(C)c2)c3ccc(O)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D22 compound treatment 1.26829902E8 -2410000.0 -0.03 1.30842621E8 -1700000.0 -0.03 -0.042 -0.9998 3209729 TimTec1_000088 Cc1cccc(c1)C2Sc3ccccc3N=C4C2C(=O)c5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D23 mock treatment 1.24859244E8 -4380000.0 -0.05 1.31843818E8 -702000.0 -0.01 -0.0474 -0.8418 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 D24 mock treatment 1.17286347E8 -1.2E7 -0.15 1.35944994E8 3400000.0 0.06 -0.0649 -0.4034 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E01 compound treatment 3.4108974E7 -9.51E7 -1.19 9.4353303E7 -3.82E7 -0.65 -1.3061 -0.9599 3209730 TimTec1_000089 CSc1ccccc1NC(=O)c2cc3NC4C(CCc5ccccc45)C(n3n2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E02 compound treatment 4.257971E7 -8.67E7 -1.09 9.4064625E7 -3.85E7 -0.66 -1.2345 -0.9712 3081503 TimTec1_000090 Nc1c(C#N)c(cc(c1C#N)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E03 compound treatment 4.8167737E7 -8.11E7 -1.02 1.12066084E8 -2.05E7 -0.35 -0.967 -0.8989 3081507 TimTec1_000091 Cc1c(Br)c(nn1CC(=O)N2CCOCC2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E04 compound treatment 7.6828016E7 -5.24E7 -0.66 1.03345752E8 -2.92E7 -0.5 -0.8184 -0.9908 1912602 TimTec1_000092 Brc1cccc(c1)C2C3CCCCC3=C(C#N)C(=O)C2(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E05 compound treatment 1.19578481E8 -9660000.0 -0.12 1.16155169E8 -1.64E7 -0.28 -0.2841 -0.9296 3209731 TimTec1_000093 C[N+](C)(C)CC1CCCC1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E06 compound treatment 1.20786385E8 -8450000.0 -0.11 1.1740863E8 -1.51E7 -0.26 -0.2582 -0.9223 3081510 TimTec1_000094 [N-]=[N+]=NCc1noc(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E07 compound treatment 1.26425769E8 -2820000.0 -0.04 1.18296816E8 -1.42E7 -0.24 -0.1974 -0.8011 1182023 TimTec1_000095 CCCN(C#N)c1nc(NC(C)C)nc(NC(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E08 compound treatment 1.24493915E8 -4750000.0 -0.06 1.23000391E8 -9550000.0 -0.16 -0.1577 -0.9065 3081512 TimTec1_000096 O=C(NCC[n+]1ccc2ccccc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E09 compound treatment 1.26791484E8 -2450000.0 -0.03 1.17136515E8 -1.54E7 -0.26 -0.2082 -0.7842 1029436 TimTec1_000097 OC(=O)CCC(=O)Oc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E10 compound treatment 1.16349082E8 -1.29E7 -0.16 1.09509048E8 -2.3E7 -0.39 -0.3932 -0.9225 3209732 TimTec1_000098 Nc1ccc(OCC(O)C[n+]2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E11 compound treatment 1.21633111E8 -7610000.0 -0.1 1.23248942E8 -9300000.0 -0.16 -0.18 -0.9701 3081515 TimTec1_000099 O=C(Nc1cccc(NC(=O)/C=C/c2ccco2)n1)/C=C/c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E12 compound treatment 1.15186307E8 -1.41E7 -0.18 1.19138845E8 -1.34E7 -0.23 -0.287 -0.9915 1009007 TimTec1_000100 CCCC(=O)NCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E13 compound treatment 1.16427936E8 -1.28E7 -0.16 1.17075802E8 -1.55E7 -0.26 -0.3009 -0.9714 1705451 TimTec1_000101 CC1C2COCC2CC(C1O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E14 compound treatment 1.35062019E8 5820000.0 0.07 1.26203248E8 -6340000.0 -0.11 -0.0251 -0.1921 1074947 TimTec1_000102 Cc1ccc[n+](Cc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E15 compound treatment 1.3227616E8 3030000.0 0.04 1.32926846E8 381000.0 0.01 0.0315 0.8164 1394494 TimTec1_000103 Nc1ccc(c2nc3cc(Cl)ccc3o2)c(O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E16 compound treatment 1.25090649E8 -4150000.0 -0.05 1.19494651E8 -1.31E7 -0.22 -0.1948 -0.8491 3209733 TimTec1_000104 CN(C)/C=C(\C=[N+](C)C)/c1cc([nH]n1)\C(=C/N(C)C)\C=[N+](C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E17 compound treatment 1.29245625E8 4340.0 0.0 1.25106671E8 -7440000.0 -0.13 -0.09 -0.7068 3081522 TimTec1_000105 Oc1ccc(Cl)cc1/N=C/c2ccc(o2)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E18 compound treatment 1.37577006E8 8340000.0 0.1 1.37718938E8 5170000.0 0.09 0.1366 0.9966 1633318 TimTec1_000106 Oc1ccc2occ(C(=O)c3ccc(Oc4ccccc4)cc3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E19 compound treatment 1.33781142E8 4540000.0 0.06 1.26494036E8 -6050000.0 -0.1 -0.033 -0.279 1221609 TimTec1_000107 CCOC(=O)C1(COC(=O)C1)c2csc(N)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E20 compound treatment 1.37832396E8 8590000.0 0.11 1.29762082E8 -2780000.0 -0.05 0.0425 0.3608 1365512 TimTec1_000108 CSc1c(CC(=O)NCCc2ccccc2)n(C)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E21 compound treatment 1.36797952E8 7560000.0 0.09 1.35493477E8 2950000.0 0.05 0.1027 0.9564 3081562 TimTec1_000109 Cc1c(/C=N/c2cccc3nsnc23)c(O)n4c5ccccc5nc4c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E22 compound treatment 9.1774057E7 -3.75E7 -0.47 1.10335417E8 -2.22E7 -0.38 -0.6012 -0.9945 1408177 TimTec1_000110 O=C(CCN1CCCCC1)c2cc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E23 mock treatment 1.29998239E8 757000.0 0.01 1.26994761E8 -5550000.0 -0.1 -0.0605 -0.6333 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 E24 mock treatment 1.31937858E8 2700000.0 0.03 1.17790531E8 -1.48E7 -0.25 -0.1547 -0.607 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F01 compound treatment 1.20446264E8 -8800000.0 -0.11 1.1688548E8 -1.57E7 -0.27 -0.2676 -0.923 1212077 TimTec1_000111 CCOC(=O)c1cc2ccccc2nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F02 compound treatment 7.987244E7 -4.94E7 -0.62 9.2875619E7 -3.97E7 -0.68 -0.9181 -0.9989 3209734 TimTec1_000112 C=CCNC(=O)CC1CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F03 compound treatment 1.09246664E8 -2.0E7 -0.25 7.3566916E7 -5.9E7 -1.01 -0.8913 -0.8567 3209735 TimTec1_000113 COc1ccc(O)c(c1)c2c[nH]c(=S)nc2c3cc(OC)ccc3OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F04 compound treatment 1.17381307E8 -1.19E7 -0.15 7.9326368E7 -5.32E7 -0.91 -0.7494 -0.8118 1743325 TimTec1_000114 COc1ccc2nc3-c4cccc5cccc(-c3nc2c1)c45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F05 compound treatment 1.24037452E8 -5200000.0 -0.07 7.8904447E7 -5.36E7 -0.92 -0.6954 -0.7555 2104259 TimTec1_000115 Brc1cccc(c1)c2n[nH]c(=O)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F06 compound treatment 1.20272761E8 -8970000.0 -0.11 8.9640482E7 -4.29E7 -0.73 -0.5989 -0.806 1644388 TimTec1_000116 O=S(=O)(CCc1ccncc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F07 compound treatment 1.26120983E8 -3120000.0 -0.04 1.2586832E8 -6680000.0 -0.11 -0.1085 -0.8981 1066566 TimTec1_000117 Cc1ccc(cc1)S(=O)(=O)N2CCC(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F08 compound treatment 1.26501525E8 -2740000.0 -0.03 9.7007673E7 -3.55E7 -0.61 -0.4545 -0.7459 1595822 TimTec1_000118 Nc1ccc(cc1)C(=O)NCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F09 compound treatment 1.16821675E8 -1.24E7 -0.16 7.9619789E7 -5.29E7 -0.91 -0.7508 -0.8167 3209736 TimTec1_000119 CN(C)Cc1c(C#N)c2ccccc2n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F10 compound treatment 1.13208486E8 -1.6E7 -0.2 7.7980503E7 -5.46E7 -0.93 -0.8027 -0.8401 3081571 TimTec1_000120 Cc1c(O)n(nc1/C=N/n2cnnc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F11 compound treatment 1.27770618E8 -1470000.0 -0.02 8.903691E7 -4.35E7 -0.74 -0.5397 -0.7244 3209737 TimTec1_000121 Oc1ccc(cc1)n2cccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F12 compound treatment 1.1026255E8 -1.9E7 -0.24 1.25911137E8 -6630000.0 -0.11 -0.2487 -0.9427 1378112 TimTec1_000122 CC(C)(C)C(=O)c1sc2nc3CCCc3c(c4cccs4)c2c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F13 compound treatment 1.18638385E8 -1.06E7 -0.13 1.11404165E8 -2.11E7 -0.36 -0.35 -0.9076 1389415 TimTec1_000123 Clc1cccc(OCCN2CCOCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F14 compound treatment 1.14578428E8 -1.47E7 -0.18 1.30312688E8 -2230000.0 -0.04 -0.1571 -0.8362 3209738 TimTec1_000124 COc1ccc(C/N=C/C2C(=O)N(N=C2C(F)(F)F)c3nc4ccccc4s3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F15 compound treatment 9.204657E7 -3.72E7 -0.47 9.7168386E7 -3.54E7 -0.61 -0.7581 -0.9917 1562364 TimTec1_000125 CN1CCN(CCOc2ccccc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F16 compound treatment 1.00415288E8 -2.88E7 -0.36 8.4975819E7 -4.76E7 -0.81 -0.8315 -0.9332 1380422 TimTec1_000126 Brc1ccccc1OCc2nc3ccccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F17 compound treatment 7.9492662E7 -4.97E7 -0.62 8.6745036E7 -4.58E7 -0.78 -0.9957 -0.9936 1337811 TimTec1_000127 COc1ccc(NC(=O)c2ccc3nc(C)c(C)nc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F18 compound treatment 8.7711589E7 -4.15E7 -0.52 1.30718566E8 -1830000.0 -0.03 -0.3905 -0.7482 3209739 TimTec1_000128 O=C(/C=C/C(=O)c1ccccc1)N2c3ccccc3Sc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F19 compound treatment 1.11156865E8 -1.81E7 -0.23 1.16890971E8 -1.57E7 -0.27 -0.3499 -0.9966 1683844 TimTec1_000129 CC1(C)CC(C)(c2ccccc2)c3cc(SC#N)ccc3N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F20 compound treatment 1.4350242E8 1.43E7 0.18 1.33080414E8 535000.0 0.01 0.133 0.7423 1442200 TimTec1_000130 CC1CCN(CC(O)COc2c(F)cc(Br)cc2F)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F21 compound treatment 1.06684413E8 -2.26E7 -0.28 1.08780743E8 -2.38E7 -0.41 -0.4877 -0.9843 1404864 TimTec1_000131 OCCN(CCO)Cc1c(O)ccc2occ(C(=O)c3cccs3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F22 compound treatment 1.31077409E8 1840000.0 0.02 1.21720526E8 -1.08E7 -0.19 -0.1147 -0.6145 1413355 TimTec1_000132 CSC1=NC2(CCCCC2)NC3=C1CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F23 mock treatment 1.35654607E8 6410000.0 0.08 1.23390582E8 -9160000.0 -0.16 -0.0539 -0.3061 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 F24 mock treatment 1.26588202E8 -2650000.0 -0.03 1.14895945E8 -1.76E7 -0.3 -0.2372 -0.7803 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G01 compound treatment 3.478815E7 -9.45E7 -1.18 1.06325362E8 -2.62E7 -0.45 -1.1552 -0.9117 1746897 TimTec1_000133 CC1Cc2ccccc2N1C(=O)c3cccc(n3)C(=O)N4C(C)Cc5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G02 compound treatment 5.1316976E7 -7.79E7 -0.98 1.24080768E8 -8470000.0 -0.14 -0.7937 -0.8031 1210571 TimTec1_000134 CCOC(=O)C1(C#N)C(C=C(C(=C1N)C#N)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G03 compound treatment 6.1161228E7 -6.81E7 -0.85 1.27416492E8 -5130000.0 -0.09 -0.666 -0.7757 1738871 TimTec1_000135 O=C(C1CC1(c2ccccc2)c3ccccc3)N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G04 compound treatment 1.33625576E8 4380000.0 0.05 1.48045039E8 1.55E7 0.27 0.2265 0.8359 1495985 TimTec1_000136 CC(C)Cc1cc(c(C#N)c(N)n1)c2cccc(Br)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G05 compound treatment 1.62647331E8 3.34E7 0.42 1.39525172E8 6980000.0 0.12 0.3808 0.8739 1728047 TimTec1_000137 CC(C)(C)c1cc(CCC(=O)NCCN)cc(c1O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G06 compound treatment 1.99490124E8 7.02E7 0.88 1.51699701E8 1.92E7 0.33 0.855 0.9093 1006115 TimTec1_000138 CCN(CC)C1CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G07 compound treatment 1.71293325E8 4.21E7 0.53 1.43219175E8 1.07E7 0.18 0.5022 0.8996 1442213 TimTec1_000139 CN(C)c1nc(Cl)nc(n1)N(CN2C(=O)c3ccccc3C2=O)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G08 compound treatment 1.83599358E8 5.44E7 0.68 1.41094648E8 8550000.0 0.15 0.5857 0.8397 1391498 TimTec1_000140 Cc1nc2n(C)c(=O)n(C)c(=O)c2cc1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G09 compound treatment 1.64671992E8 3.54E7 0.44 1.43926549E8 1.14E7 0.19 0.452 0.9315 1225682 TimTec1_000141 CC(C)Nc1nc(NC(C)C)nc(n1)N(C)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G10 compound treatment 1.67047715E8 3.78E7 0.47 1.40380274E8 7830000.0 0.13 0.4302 0.8728 1485808 TimTec1_000142 Cc1cccc(C[N+](C)(C)CCC(=O)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G11 compound treatment 1.64940302E8 3.57E7 0.45 1.42353429E8 9810000.0 0.17 0.4354 0.9103 1186157 TimTec1_000143 CC12CCCCC2=NC(N1O)c3ccccc3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G12 compound treatment 1.57992254E8 2.88E7 0.36 1.4137294E8 8830000.0 0.15 0.3619 0.9254 1025931 TimTec1_000144 Cc1ccc(cc1)S(=O)(=O)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G13 compound treatment 9.9091017E7 -3.02E7 -0.38 8.3882444E7 -4.87E7 -0.83 -0.8565 -0.9362 1323961 TimTec1_000145 S=C(CC(=S)N1CCOCC1)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G14 compound treatment 1.66149437E8 3.69E7 0.46 1.51539527E8 1.9E7 0.33 0.5573 0.985 3209861 TimTec1_000146 CC(=O)NC1CCCCc2sccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G15 compound treatment 1.53876851E8 2.46E7 0.31 1.43277608E8 1.07E7 0.18 0.3484 0.9691 1288570 TimTec1_000147 CCCC(CCC)c1nc2ccncc2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G16 compound treatment 1.68119456E8 3.89E7 0.49 1.52466075E8 1.99E7 0.34 0.586 0.9847 3209862 TimTec1_000148 OC1=C(C2C3C(CCCC3=O)Oc4ccccc24)C(=O)CCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G17 compound treatment 1.57820445E8 2.86E7 0.36 1.45425299E8 1.29E7 0.22 0.4094 0.9727 3081632 TimTec1_000149 OC(=O)CCC/N=C(\c1ccc(Cl)cc1)/c2cc(F)ccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G18 compound treatment 1.4525645E8 1.6E7 0.2 1.32482907E8 -62900.0 0.0 0.1413 0.7033 1713094 TimTec1_000150 CN(C)Cc1c(O)ccc2occ(C(=O)c3cccc(Br)c3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G19 compound treatment 1.62085105E8 3.28E7 0.41 1.43317099E8 1.08E7 0.18 0.4217 0.9343 3081667 TimTec1_000151 CCCC1CC(C)(OC1=O)C(=O)C[n+]2cccc(c2)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G20 compound treatment 1.52339794E8 2.31E7 0.29 1.43376569E8 1.08E7 0.19 0.336 0.9767 1405391 TimTec1_000152 COc1ccc(OC)c(c1)C(=O)c2coc3ccc(O)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G21 compound treatment 1.57784989E8 2.85E7 0.36 1.51537862E8 1.9E7 0.33 0.4831 0.9988 3081670 TimTec1_000153 CC(C)C1(CN2CC/3CN(C1)CC2)\C3=N/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G22 compound treatment 1.51400881E8 2.22E7 0.28 1.50864815E8 1.83E7 0.31 0.4183 0.9982 1185154 TimTec1_000154 CCOC(=O)Cn1c(C)c(Sc2ccccc2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G23 mock treatment 1.43889402E8 1.46E7 0.18 1.43723139E8 1.12E7 0.19 0.2652 0.9998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 G24 mock treatment 1.43598749E8 1.44E7 0.18 1.5142278E8 1.89E7 0.32 0.3558 0.9619 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H01 compound treatment 1.46834564E8 1.76E7 0.22 1.49825289E8 1.73E7 0.3 0.3652 0.9896 1114526 TimTec1_000155 NC(=O)c1ccccc1C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H02 compound treatment 1.52357343E8 2.31E7 0.29 1.3108638E8 -1460000.0 -0.02 0.1874 0.6438 3209863 TimTec1_000156 CC(C)c1ccc(cc1)C(C)(C)CO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H03 compound treatment 1.46210537E8 1.7E7 0.21 7.9880869E7 -5.27E7 -0.9 -0.4869 -0.5257 1440514 TimTec1_000157 COc1ccccc1OCCN2CCN(CC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H04 compound treatment 1.54595788E8 2.54E7 0.32 1.23322399E8 -9220000.0 -0.16 0.1133 0.319 3081674 TimTec1_000158 Cc1c(/C=C/c2ccc(Cl)cc2Cl)c(=O)n(c3ccccc3)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H05 compound treatment 1.54845648E8 2.56E7 0.32 8.0629496E7 -5.19E7 -0.89 -0.4013 -0.4247 3209864 TimTec1_000159 COc1ccc(Br)c2OCCOc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H06 compound treatment 1.53808735E8 2.46E7 0.31 1.35741395E8 3200000.0 0.05 0.2566 0.8198 3209865 TimTec1_000160 COc1ccc(NC(=O)CC(=O)CSc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H07 compound treatment 1.53846459E8 2.46E7 0.31 1.47150822E8 1.46E7 0.25 0.395 0.9945 1282382 TimTec1_000161 CN1CCN(Cc2c(C#N)c3ccccc3n2C)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H08 compound treatment 1.63344246E8 3.41E7 0.43 1.18426361E8 -1.41E7 -0.24 0.1316 0.2678 1156260 TimTec1_000162 O=C(CSc1nc2ccccc2o1)Nc3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H09 compound treatment 1.54644326E8 2.54E7 0.32 8.1519803E7 -5.1E7 -0.87 -0.3923 -0.4219 1296268 TimTec1_000163 Cn1c(CN2CCOCC2)c(C#N)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H10 compound treatment 1.51985416E8 2.27E7 0.29 1.25892822E8 -6650000.0 -0.11 0.1212 0.3946 1566355 TimTec1_000164 C1CCC(CC1)Nc2c(nnn2C3CCCCC3)c4ccn[nH]4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H11 compound treatment 1.58746759E8 2.95E7 0.37 1.26069949E8 -6480000.0 -0.11 0.1833 0.4745 3081679 TimTec1_000165 CNC(=O)CCc1cc2ccccc2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H12 compound treatment 1.15170577E8 -1.41E7 -0.18 1.09061064E8 -2.35E7 -0.4 -0.4091 -0.9317 1429944 TimTec1_000166 NC(=S)c1cnc2ccccn2c1=N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H13 compound treatment 1.42658838E8 1.34E7 0.17 8.0346027E7 -5.22E7 -0.89 -0.5128 -0.564 1210033 TimTec1_000167 O=C(CCN1CCN(CC1)c2ccccc2)Nc3nccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H14 compound treatment 1.55522679E8 2.63E7 0.33 1.4075506E8 8210000.0 0.14 0.3325 0.9277 3209866 TimTec1_000168 FC(F)(F)c1[nH]n(c2nc3ccccc3s2)c(=O)c1/C=N/CCN4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H15 compound treatment 1.56994075E8 2.78E7 0.35 1.346099E8 2060000.0 0.04 0.2712 0.7749 3081684 TimTec1_000169 COc1ccc(/C=N/c2oc(C)c(C)c2C#N)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H16 compound treatment 1.56171162E8 2.69E7 0.34 8.9448177E7 -4.31E7 -0.74 -0.2828 -0.3485 3209867 TimTec1_000170 C[n+]1c(COc2ccccc2O)sc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H17 compound treatment 1.26413312E8 -2830000.0 -0.04 1.10683041E8 -2.19E7 -0.37 -0.2897 -0.7707 1912978 TimTec1_000171 CC(=O)N1c2ccccc2C(C)(CC1(C)C)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H18 compound treatment 1.5325488E8 2.4E7 0.3 1.39493351E8 6950000.0 0.12 0.2971 0.9174 3081687 TimTec1_000172 Cn1ccnc1C(=O)Oc2ccccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H19 compound treatment 1.486739E8 1.94E7 0.24 1.36668689E8 4120000.0 0.07 0.2223 0.8759 1280653 TimTec1_000173 CC1=CC(C)(C)N(c2ccccc12)S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H20 compound treatment 1.50338373E8 2.11E7 0.26 1.32662341E8 117000.0 0.0 0.1885 0.7124 3209868 TimTec1_000174 O=c1[nH]c2ccc(/N=C/c3ccc4OCOc4c3)cc2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H21 compound treatment 1.54402966E8 2.52E7 0.32 1.4941879E8 1.69E7 0.29 0.4274 0.999 3081729 TimTec1_000175 Nc1no[n+]([O-])c1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H22 compound treatment 1.31061925E8 1820000.0 0.02 1.20945654E8 -1.16E7 -0.2 -0.1243 -0.6217 3081731 TimTec1_000176 CCOc1ccc2S/C(=C/NC(C)CC)/C(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H23 mock treatment 1.44416726E8 1.52E7 0.19 1.38557026E8 6010000.0 0.1 0.2074 0.9583 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 H24 mock treatment 1.44063947E8 1.48E7 0.19 1.49493103E8 1.69E7 0.29 0.3366 0.9769 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I01 compound treatment 4.518193E7 -8.41E7 -1.05 1.31222748E8 -1320000.0 -0.02 -0.7616 -0.7221 1160113 TimTec1_000177 Cc1ccccc1OCC(=O)Nc2ccc3nn(nc3c2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I02 compound treatment 7.7195244E7 -5.2E7 -0.65 1.37516852E8 4970000.0 0.09 -0.4015 -0.6098 1912584 TimTec1_000178 Nc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I03 compound treatment 8.5227478E7 -4.4E7 -0.55 1.4576307E8 1.32E7 0.23 -0.2304 -0.3862 3081734 TimTec1_000179 COC(=O)CCC(=O)Nc1nccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I04 compound treatment 1.14160134E8 -1.51E7 -0.19 1.17685833E8 -1.49E7 -0.25 -0.3136 -0.9894 1175548 TimTec1_000180 CC(=O)Nc1nc(cc(c1C#N)c2ccccc2)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I05 compound treatment 1.54047051E8 2.48E7 0.31 1.52801111E8 2.03E7 0.35 0.4652 0.9985 1060191 TimTec1_000181 S=C1N(CN2CCCCC2)CCN1CN3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I06 compound treatment 1.59261352E8 3.0E7 0.38 1.44311956E8 1.18E7 0.2 0.4087 0.957 3209869 TimTec1_000182 CC[N+](C)(CC)Cc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I07 compound treatment 1.60322035E8 3.11E7 0.39 1.81082997E8 4.85E7 0.83 0.8632 0.9405 3209870 TimTec1_000183 Cc1cc(NN)nc(SCC(=O)NN)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I08 compound treatment 1.59908176E8 3.07E7 0.38 1.53840139E8 2.13E7 0.36 0.5298 0.9996 1289525 TimTec1_000184 C[N+]1(CC(O)C[N+]2(C)CCCCC2)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I09 compound treatment 1.57284411E8 2.8E7 0.35 1.62703264E8 3.02E7 0.52 0.6138 0.9825 1505713 TimTec1_000185 C1=C(N=C2C=Cc3nonc3C12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I10 compound treatment 1.63400535E8 3.42E7 0.43 1.83660435E8 5.11E7 0.87 0.9217 0.946 1080215 TimTec1_000186 OP(=O)(Nc1ccccc1)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I11 compound treatment 1.41041293E8 1.18E7 0.15 1.51760867E8 1.92E7 0.33 0.3373 0.935 3209871 TimTec1_000187 Cc1c(Br)c(nn1CC(=O)N)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I12 compound treatment 1.40527737E8 1.13E7 0.14 1.670847E8 3.45E7 0.59 0.5182 0.8523 1668354 TimTec1_000188 O=C(N1CCCCC1)c2ccccc2C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I13 compound treatment 1.34403138E8 5160000.0 0.06 1.36771515E8 4230000.0 0.07 0.0969 0.9985 1230919 TimTec1_000189 CN(C)CCNc1nc(no1)c2noc(NCCN(C)C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I14 compound treatment 1.34134511E8 4890000.0 0.06 1.49362546E8 1.68E7 0.29 0.247 0.839 1641088 TimTec1_000190 C[N+]1(CC(O)CN2CCCC2=O)CCCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I15 compound treatment 1.17038113E8 -1.22E7 -0.15 1.50674421E8 1.81E7 0.31 0.1112 0.3213 1479834 TimTec1_000191 CC1(C)CC(CC(C)(C)N1)NC(=O)N2c3ccccc3CCc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I16 compound treatment 1.30440057E8 1200000.0 0.02 1.50874595E8 1.83E7 0.31 0.2325 0.7401 3209872 TimTec1_000192 CCOC(=O)C1(C#N)C(C#N)(C(=O)OCC)C1(C#N)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I17 compound treatment 1.18024479E8 -1.12E7 -0.14 1.33308022E8 762000.0 0.01 -0.0903 -0.6388 1350657 TimTec1_000193 COc1ccc2NC(C)(C)c3ssc(=S)c3-c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I18 compound treatment 1.36798933E8 7560000.0 0.09 1.40383064E8 7840000.0 0.13 0.1619 0.9856 1439817 TimTec1_000194 CC(=O)Oc1ccc2occ(C(=O)c3cc4ccccc4o3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I19 compound treatment 1.46901754E8 1.77E7 0.22 1.63920759E8 3.14E7 0.54 0.5364 0.9233 1619809 TimTec1_000195 Nc1nc(cc(c1C#N)c2ccccc2Cl)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I20 compound treatment 1.27121244E8 -2120000.0 -0.03 1.31509562E8 -1040000.0 -0.02 -0.0313 -0.9806 1402303 TimTec1_000196 CN(C)CCC(=O)c1coc2ccc(OC(=O)C)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I21 compound treatment 1.51331123E8 2.21E7 0.28 1.5218582E8 1.96E7 0.34 0.4337 0.9954 3209873 TimTec1_000197 C/C(=N\n1nnnc1Nc2ccccc2)/c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I22 compound treatment 1.6797413E8 3.87E7 0.49 1.61660352E8 2.91E7 0.5 0.696 0.9999 1447918 TimTec1_000198 COC(=O)CCC(=O)c1cc2cc(Br)ccc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I23 mock treatment 1.50154796E8 2.09E7 0.26 1.39933027E8 7390000.0 0.13 0.2749 0.944 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 I24 mock treatment 1.61423932E8 3.22E7 0.4 1.27182344E8 -5360000.0 -0.09 0.2206 0.5327 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J01 compound treatment 1.24384258E8 -4860000.0 -0.06 1.36233405E8 3690000.0 0.06 0.0016 0.0177 1078582 TimTec1_000199 NC(=O)c1ccc2ccccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J02 compound treatment 1.61880888E8 3.26E7 0.41 1.19103344E8 -1.34E7 -0.23 0.1268 0.27 1032512 TimTec1_000200 O=C1N(CNc2ccccc2)C(=O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J03 compound treatment 1.48956727E8 1.97E7 0.25 1.21841746E8 -1.07E7 -0.18 0.0453 0.1472 1725358 TimTec1_000201 Cc1ccc(cc1)S(=O)(=O)CCN2CCN(CC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J04 compound treatment 1.72901194E8 4.37E7 0.55 1.28893816E8 -3650000.0 -0.06 0.3431 0.6224 1122981 TimTec1_000202 O=C1NC(=O)c2cc(ccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J05 compound treatment 1.57932612E8 2.87E7 0.36 1.01338909E8 -3.12E7 -0.53 -0.1232 -0.1913 1020688 TimTec1_000203 Cc1ccc(NC(=O)CC(=O)Nc2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J06 compound treatment 1.45597097E8 1.64E7 0.21 1.3446915E8 1920000.0 0.03 0.1684 0.8102 1386865 TimTec1_000204 COC(=O)c1ccc(NC(=O)COc2cccc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J07 compound treatment 1.30734118E8 1490000.0 0.02 1.17175017E8 -1.54E7 -0.26 -0.1728 -0.6551 1498066 TimTec1_000205 CC(=O)Nc1c(oc2ccccc12)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J08 compound treatment 1.58280056E8 2.9E7 0.36 1.16111438E8 -1.64E7 -0.28 0.0587 0.1274 1326858 TimTec1_000206 CN1CCc2c(C1)c(nc3[nH]nc(N)c23)N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J09 compound treatment 1.41968462E8 1.27E7 0.16 9.9357759E7 -3.32E7 -0.57 -0.2888 -0.4894 1734489 TimTec1_000207 Cn1c(CSCc2ccccc2)c(C#N)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J10 compound treatment 1.49878213E8 2.06E7 0.26 1.26076969E8 -6470000.0 -0.11 0.1048 0.372 3209874 TimTec1_000208 O/N=C\1/C2CN3CC1(Cc4ccccc4)CN(C2)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J11 compound treatment 1.39614138E8 1.04E7 0.13 1.30179039E8 -2370000.0 -0.04 0.0634 0.4649 3081797 TimTec1_000209 S(c1ccccn1)c2ncnc3c4ccccc4oc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J12 compound treatment 1.45107501E8 1.59E7 0.2 1.13325631E8 -1.92E7 -0.33 -0.0919 -0.239 3209875 TimTec1_000210 CCOC(=O)[C@@]1(C#N)[C@H]([C@@H](N2C=C(C=C[C@H]21)C(=O)N)C(=O)N)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J13 compound treatment 1.48159741E8 1.89E7 0.24 1.32844864E8 299000.0 0.01 0.1714 0.7222 3081799 TimTec1_000211 C(Sc1ncnc2c3ccccc3oc12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J14 compound treatment 1.73198152E8 4.4E7 0.55 1.45001109E8 1.25E7 0.21 0.5407 0.9145 3081800 TimTec1_000212 FC(F)(F)c1[nH]n(c2nc3ccccc3s2)c(=O)c1/C=N/Cc4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J15 compound treatment 1.50086832E8 2.08E7 0.26 1.24614019E8 -7930000.0 -0.14 0.0889 0.3017 1498770 TimTec1_000213 COc1cc(OC)cc(c1)C(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J16 compound treatment 1.57846162E8 2.86E7 0.36 1.38415106E8 5870000.0 0.1 0.3248 0.8716 1358111 TimTec1_000214 Oc1ccccc1OCC(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J17 compound treatment 1.51969449E8 2.27E7 0.29 1.41009551E8 8460000.0 0.14 0.3041 0.9507 1091978 TimTec1_000215 CCOC(=O)CN=C(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J18 compound treatment 1.46142888E8 1.69E7 0.21 1.37538318E8 4990000.0 0.09 0.2104 0.9202 1917358 TimTec1_000216 CN1CCN(CC(O)COCCC2(CC3CC4CC(C3)C2)C4)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J19 compound treatment 2.04330097E8 7.51E7 0.94 2.12532134E8 8.0E7 1.37 1.6342 0.9833 1066363 TimTec1_000217 COc1ccc2NC(C)(C)C=C(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J20 compound treatment 1.23389209E8 -5850000.0 -0.07 1.16296315E8 -1.62E7 -0.28 -0.2486 -0.8641 1921867 TimTec1_000218 On1c(nc-2c1CCc3c2no[n+]3[O-])c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J21 compound treatment 1.42221927E8 1.3E7 0.16 1.44093904E8 1.15E7 0.2 0.2549 0.9954 3081805 TimTec1_000219 Nc1c(no[n+]1[O-])C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J22 compound treatment 1.54983702E8 2.57E7 0.32 1.45807674E8 1.33E7 0.23 0.3889 0.9851 1879059 TimTec1_000220 CNC(=O)N(Cc1cccnc1)Cc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J23 mock treatment 1.58549061E8 2.93E7 0.37 1.37507807E8 4960000.0 0.08 0.32 0.8481 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 J24 mock treatment 1.46060217E8 1.68E7 0.21 1.44615189E8 1.21E7 0.21 0.2953 0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K01 compound treatment 3.9098316E7 -9.01E7 -1.13 9.5865371E7 -3.67E7 -0.63 -1.2436 -0.9615 1259801 TimTec1_000221 CS(=O)(=O)c1ccc2nc(NC(=O)C3CCCO3)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K02 compound treatment 6.7116779E7 -6.21E7 -0.78 1.07541397E8 -2.5E7 -0.43 -0.8537 -0.9602 1151146 TimTec1_000222 Nc1c(C#N)c(c2ccccc2)c3CCCCc3c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K03 compound treatment 8.2878893E7 -4.64E7 -0.58 1.18284287E8 -1.43E7 -0.24 -0.5839 -0.9257 1392387 TimTec1_000223 Brc1ccc(o1)C(=O)Nc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K04 compound treatment 1.41697702E8 1.25E7 0.16 1.33687002E8 1140000.0 0.02 0.1243 0.7894 1275980 TimTec1_000224 Clc1ccc(OCC(=O)NCC=C)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K05 compound treatment 1.52607116E8 2.34E7 0.29 1.29589628E8 -2960000.0 -0.05 0.1715 0.5765 1285366 TimTec1_000225 Cc1cccc(CN2CCN(Cc3cccc(C)c3O)CC2)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K06 compound treatment 1.63890187E8 3.46E7 0.43 1.39853082E8 7310000.0 0.13 0.3958 0.8751 3081809 TimTec1_000226 Cc1cc(C)nc(SCC(=O)NN)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K07 compound treatment 1.71201062E8 4.2E7 0.53 1.49045048E8 1.65E7 0.28 0.5719 0.9574 1584109 TimTec1_000227 NNC(=O)C1CC2CC1CC2C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K08 compound treatment 1.62131978E8 3.29E7 0.41 1.16133333E8 -1.64E7 -0.28 0.0931 0.1865 1914424 TimTec1_000228 C(=N/C(\N=C\c1ccccc1)c2ccccc2)\c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K09 compound treatment 1.57805004E8 2.86E7 0.36 1.10988864E8 -2.16E7 -0.37 -0.0076 -0.0147 3081861 TimTec1_000229 COC(=O)c1ccc(NC(=S)NC(=O)N2CCOCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K10 compound treatment 1.60189605E8 3.09E7 0.39 1.33201495E8 656000.0 0.01 0.2825 0.7272 3209999 TimTec1_000230 CC(=O)OC1COC(NC(=S)Oc2ccccc2)C(OC(=O)C)C1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K11 compound treatment 1.64448518E8 3.52E7 0.44 1.40062345E8 7520000.0 0.13 0.4033 0.8767 3081863 TimTec1_000231 CCOC(=O)Cn1nc(cc1C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K12 compound treatment 1.34549671E8 5310000.0 0.07 1.41415229E8 8870000.0 0.15 0.1544 0.9316 3210000 TimTec1_000232 COc1ccc(/C=C/C(=O)OC2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K13 compound treatment 1.16425299E8 -1.28E7 -0.16 1.0899643E8 -2.35E7 -0.4 -0.3987 -0.9187 3081865 TimTec1_000233 c1ccc(cc1)c2cnc3nonc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K14 compound treatment 1.75477017E8 4.62E7 0.58 1.07340726E8 -2.52E7 -0.43 0.105 0.1453 1474168 TimTec1_000234 COc1ccc(CCN(C)C(=S)NN)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K15 compound treatment 8.0788143E7 -4.85E7 -0.61 8.1842878E7 -5.07E7 -0.87 -1.0435 -0.9848 1445690 TimTec1_000235 OC(=O)c1cc2cccc(c2cc1O)S(=O)(=O)N3CCCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K16 compound treatment 1.2939815E8 157000.0 0.0 1.31323003E8 -1220000.0 -0.02 -0.0134 -0.6378 1033126 TimTec1_000236 Cc1ccc(cc1)S(=O)(=O)Nc2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K17 compound treatment 1.42426564E8 1.32E7 0.17 1.52890537E8 2.03E7 0.35 0.3632 0.9421 1183681 TimTec1_000237 COc1cc(NC(=O)Cc2ccc(F)cc2)cc(c1)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K18 compound treatment 1.21232757E8 -8010000.0 -0.1 1.45191497E8 1.26E7 0.22 0.082 0.3437 1604299 TimTec1_000238 COc1cc2c(NC(=O)C)c(CN(C)C)oc2c(Cl)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K19 compound treatment 1.18518298E8 -1.07E7 -0.13 9.9659425E7 -3.29E7 -0.56 -0.4932 -0.8521 3210001 TimTec1_000239 NS(=O)(=O)c1ccc(NC=C2C(=O)c3ccccc3C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K20 compound treatment 9.3158701E7 -3.61E7 -0.45 1.17090944E8 -1.55E7 -0.26 -0.5071 -0.9673 3081870 TimTec1_000240 CCOC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K21 compound treatment 1.22073859E8 -7170000.0 -0.09 1.35250192E8 2700000.0 0.05 -0.0308 -0.305 3210002 TimTec1_000241 S=c1n(CN(Cc2ccccc2)Cc3ccccc3)nnn1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K22 compound treatment 8.1212699E7 -4.8E7 -0.6 1.38801855E8 6260000.0 0.11 -0.3503 -0.5724 1023688 TimTec1_000242 CN(C)CCC(=O)c1ccco1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K23 mock treatment 1.22817554E8 -6420000.0 -0.08 1.3589378E8 3350000.0 0.06 -0.0165 -0.1664 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 K24 mock treatment 1.15797253E8 -1.34E7 -0.17 1.45669163E8 1.31E7 0.22 0.0396 0.141 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L01 compound treatment 1.09683882E8 -1.96E7 -0.25 8.3515593E7 -4.9E7 -0.84 -0.767 -0.8771 1264988 TimTec1_000243 COc1cc(N)c(Cl)cc1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L02 compound treatment 7.489304E7 -5.43E7 -0.68 8.4288314E7 -4.83E7 -0.83 -1.0662 -0.9955 1706058 TimTec1_000244 CC(=O)N(CN1C(=O)c2ccccc2C1=O)c3ccccc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L03 compound treatment 7.9997572E7 -4.92E7 -0.62 1.10520029E8 -2.2E7 -0.38 -0.7034 -0.972 1357677 TimTec1_000245 CNC(=O)c1cnc2cc(Cl)ccc2c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L04 compound treatment 1.26167222E8 -3070000.0 -0.04 1.00738734E8 -3.18E7 -0.54 -0.4123 -0.7553 1569209 TimTec1_000246 O=S(=O)(NC1c2ccccc2Oc3ccccc13)c4ccc5ccccc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L05 compound treatment 1.36037214E8 6800000.0 0.09 7.1295536E7 -6.13E7 -1.05 -0.6811 -0.6475 1015215 TimTec1_000247 COc1ccc(NC(=O)CC(=O)Nc2ccc(OC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L06 compound treatment 1.17685566E8 -1.16E7 -0.14 1.17116773E8 -1.54E7 -0.26 -0.2893 -0.9601 1490465 TimTec1_000248 COc1ccc(SCC(=O)Nc2ccccn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L07 compound treatment 1.1239159E8 -1.68E7 -0.21 1.00089683E8 -3.25E7 -0.56 -0.5423 -0.9123 1204062 TimTec1_000249 CSc1c(CC(=O)NN)n(C)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L08 compound treatment 1.30013151E8 772000.0 0.01 7.5610515E7 -5.69E7 -0.97 -0.6823 -0.7 1235682 TimTec1_000250 CCc1nc2[nH]nc(N)c2c3CC(C)(C)OCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L09 compound treatment 1.02984502E8 -2.63E7 -0.33 9.2445206E7 -4.01E7 -0.69 -0.7183 -0.9434 3081877 TimTec1_000251 O=C(/C=C/N1CCOCC1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L10 compound treatment 8.9443204E7 -3.98E7 -0.5 6.5434793E7 -6.71E7 -1.15 -1.1653 -0.9303 3210003 TimTec1_000252 C[n+]1ccc(/C=C/c2cccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L11 compound treatment 1.13929467E8 -1.53E7 -0.19 8.0702983E7 -5.18E7 -0.89 -0.7633 -0.8407 1338690 TimTec1_000253 CN(C)Cc1c(O)ccc2occ(C(=O)c3ccc(C)cc3)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L12 compound treatment 1.2043894E8 -8800000.0 -0.11 1.2988072E8 -2670000.0 -0.05 -0.1103 -0.9235 1654307 TimTec1_000254 CC1(C)Cc2c(C#N)c3nc(cnn3c2CO1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L13 compound treatment 1.03341194E8 -2.59E7 -0.32 1.07294066E8 -2.53E7 -0.43 -0.5354 -0.9901 1245793 TimTec1_000255 CCc1oc2ccccc2c1C(=O)c3ccc(OC(=O)C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L14 compound treatment 1.16264787E8 -1.3E7 -0.16 7.7434689E7 -5.51E7 -0.94 -0.7822 -0.817 3081942 TimTec1_000256 CN(C)S(=O)(=O)c1ccc(N/C=C\2/C(=C(C#N)C(=O)N(C)C2=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L15 compound treatment 1.24411219E8 -4830000.0 -0.06 1.12380053E8 -2.02E7 -0.35 -0.2869 -0.8187 1570064 TimTec1_000257 Cc1ccc2nc(Nc3ccccc3)cc(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L16 compound treatment 1.37500821E8 8260000.0 0.1 1.22481641E8 -1.01E7 -0.17 -0.0486 -0.2415 1509985 TimTec1_000258 C=CCC1CCCCC1NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L17 compound treatment 1.21845897E8 -7400000.0 -0.09 1.18393903E8 -1.42E7 -0.24 -0.2369 -0.9132 1455868 TimTec1_000259 COc1cccc(NC(=O)c2ccc(OC(=S)N3CCC(C)CC3)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L18 compound treatment 1.38069806E8 8830000.0 0.11 1.17111077E8 -1.54E7 -0.26 -0.1085 -0.3788 3210004 TimTec1_000260 Fc1ccc(/N=C/c2ccc(OC(=O)c3ccco3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L19 compound treatment 1.18470664E8 -1.08E7 -0.14 1.44522275E8 1.2E7 0.21 0.0494 0.2013 1369950 TimTec1_000261 CCOc1ccc2N(C)C(C)(C)c3ssc(=S)c3-c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L20 compound treatment 1.16890604E8 -1.24E7 -0.15 1.12227714E8 -2.03E7 -0.35 -0.3555 -0.9337 3210005 TimTec1_000262 NC(=O)[C@H]1[C@H](c2ccc(F)cc2)C(C#N)(C#N)[C@H]3N1C=Cc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L21 compound treatment 1.11107919E8 -1.81E7 -0.23 1.18250631E8 -1.43E7 -0.24 -0.3339 -0.9993 1298997 TimTec1_000263 CCOC(=O)c1c(CNc2cccc(c2)C(=O)N)n(C)c3cc(Br)c(OC(=O)C)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L22 compound treatment 1.19198753E8 -1.0E7 -0.13 1.33191207E8 645000.0 0.01 -0.0813 -0.6426 1677367 TimTec1_000264 O=C(Nc1c(cnn1c2ccccc2)C(=O)N3CCCCC3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L23 mock treatment 1.29350197E8 109000.0 0.0 1.31237219E8 -1310000.0 -0.02 -0.0149 -0.6627 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 L24 mock treatment 1.26366455E8 -2870000.0 -0.04 1.53001377E8 2.05E7 0.35 0.2221 0.6309 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M01 compound treatment 3.8034658E7 -9.12E7 -1.14 1.03166255E8 -2.94E7 -0.5 -1.1646 -0.9319 1321921 TimTec1_000265 OC1(N(C(=O)Nc2ccccc21)c3ccccc3)C(=O)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M02 compound treatment 6.0587499E7 -6.87E7 -0.86 1.13343222E8 -1.92E7 -0.33 -0.8414 -0.9128 3081949 TimTec1_000266 CCC1(C)C/C(=C\C)/C(=C(N)C1(C#N)C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M03 compound treatment 8.1485983E7 -4.78E7 -0.6 1.23857174E8 -8690000.0 -0.15 -0.5288 -0.8567 1666559 TimTec1_000267 COc1cc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccco3)cc2)ncn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M04 compound treatment 1.32445274E8 3200000.0 0.04 1.27631572E8 -4910000.0 -0.08 -0.0311 -0.3332 1006470 TimTec1_000268 C[N+](C)(Cc1ccccc1)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M05 compound treatment 1.36528041E8 7290000.0 0.09 1.21929642E8 -1.06E7 -0.18 -0.0639 -0.314 3210006 TimTec1_000269 O=S(N1CCOCC1)c2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M06 compound treatment 1.23244771E8 -6000000.0 -0.08 1.23287969E8 -9260000.0 -0.16 -0.1652 -0.942 3081952 TimTec1_000270 S=C(Nc1ccccc1)N=S(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M07 compound treatment 1.18616205E8 -1.06E7 -0.13 1.29551952E8 -2990000.0 -0.05 -0.1305 -0.9138 1489996 TimTec1_000271 COC1OC2COC(OC2CC1O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M08 compound treatment 1.20201954E8 -9040000.0 -0.11 1.30698639E8 -1850000.0 -0.03 -0.1025 -0.8711 3210007 TimTec1_000272 O=C(c1ccccc1)c2cc[n+](Cc3ccccn3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M09 compound treatment 9.9847853E7 -2.94E7 -0.37 1.16214459E8 -1.63E7 -0.28 -0.4584 -0.9907 3210008 TimTec1_000273 Cc1ccc(/C=C/C(=O)NC(=S)N2CCN(CC2)c3ccc(F)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M10 compound treatment 9.5614142E7 -3.36E7 -0.42 1.21062165E8 -1.15E7 -0.2 -0.4373 -0.9396 1433383 TimTec1_000274 CCCOC(=S)NC1OCC(O)C(O)C1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M11 compound treatment 8.5485688E7 -4.38E7 -0.55 1.18438849E8 -1.41E7 -0.24 -0.5589 -0.932 1720341 TimTec1_000275 O=C(Nc1ccc(cc1)c2ccccc2)C3CC3c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M12 compound treatment 6.9091912E7 -6.01E7 -0.75 1.07844106E8 -2.47E7 -0.42 -0.8325 -0.9625 3081955 TimTec1_000276 COc1ccc(/C=C/C(=O)NC(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M13 compound treatment 9.6884883E7 -3.24E7 -0.41 1.15374268E8 -1.72E7 -0.29 -0.4949 -0.9874 1475730 TimTec1_000277 CCOC(=O)c1nonc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M14 compound treatment 8.5664656E7 -4.36E7 -0.55 1.10485718E8 -2.21E7 -0.38 -0.6536 -0.9837 3082017 TimTec1_000278 Clc1ccc(cc1)C2=NN=C(SC2)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M15 compound treatment 1.02237113E8 -2.7E7 -0.34 1.33572993E8 1030000.0 0.02 -0.2271 -0.6695 1344248 TimTec1_000279 CCN(CC)CCC(O)(C1CCCCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M16 compound treatment 1.10699493E8 -1.85E7 -0.23 1.2567111E8 -6870000.0 -0.12 -0.2477 -0.9502 1532600 TimTec1_000280 Cc1nc2ccccc2cc1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M17 compound treatment 1.27325011E8 -1920000.0 -0.02 1.08558703E8 -2.4E7 -0.41 -0.3073 -0.7472 3210120 TimTec1_000281 COc1ccc(cc1)c2cc(n3nc(cc3n2)C(=O)NCCN4CCOCC4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M18 compound treatment 1.05611563E8 -2.36E7 -0.3 1.2544504E8 -7100000.0 -0.12 -0.2956 -0.9225 1325986 TimTec1_000282 Cc1ccc(o1)C(=O)c2coc3ccc(O)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M19 compound treatment 1.03654588E8 -2.56E7 -0.32 1.14581612E8 -1.8E7 -0.31 -0.4444 -0.9998 3210121 TimTec1_000283 OCC(CO)(CO)NC=C1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M20 compound treatment 1.20813215E8 -8430000.0 -0.11 1.55324167E8 2.28E7 0.39 0.201 0.4974 1295715 TimTec1_000284 OC(=O)CCCc1cc2cc(Br)ccc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M21 compound treatment 1.19555698E8 -9690000.0 -0.12 1.21801219E8 -1.07E7 -0.18 -0.216 -0.9797 3210122 TimTec1_000285 Brc1ccc(/N=C(\c2ccccc2)/c3ccncc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M22 compound treatment 1.21378624E8 -7860000.0 -0.1 1.45425161E8 1.29E7 0.22 0.0862 0.3567 1536799 TimTec1_000286 Clc1cccc(NC(=O)NCCN2CCCCC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M23 mock treatment 1.16796175E8 -1.24E7 -0.16 1.23664173E8 -8880000.0 -0.15 -0.2179 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 M24 mock treatment 1.27413227E8 -1830000.0 -0.02 1.27122812E8 -5420000.0 -0.09 -0.0819 -0.8561 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N01 compound treatment 1.29484558E8 243000.0 0.0 9.1283827E7 -4.13E7 -0.71 -0.4973 -0.704 1530149 TimTec1_000287 CCCCN1CCC(CC1)(Nc2ccccc2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N02 compound treatment 1.29232501E8 -8780.0 0.0 1.22755513E8 -9790000.0 -0.17 -0.1186 -0.7076 1146434 TimTec1_000288 O=C(COC(=O)c1ccc(cc1)N2C(=O)c3ccccc3C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N03 compound treatment 9.988594E7 -2.94E7 -0.37 7.772017E7 -5.48E7 -0.94 -0.924 -0.9165 1353615 TimTec1_000289 CCOC(=O)c1c(CN(CC)CC)oc2ccc(OC)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N04 compound treatment 1.26935669E8 -2310000.0 -0.03 7.9838927E7 -5.27E7 -0.9 -0.6584 -0.7294 1022729 TimTec1_000290 O=C1N(C2c3ccccc3Oc4ccccc24)C(=O)c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N05 compound treatment 1.4730541E8 1.81E7 0.23 8.8318049E7 -4.42E7 -0.76 -0.3751 -0.4747 3082023 TimTec1_000291 O=C1N(/N=C/c2ccccc2)C(=O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N06 compound treatment 1.30908841E8 1670000.0 0.02 1.46675074E8 1.41E7 0.24 0.1858 0.7654 3210123 TimTec1_000292 O=C(CSc1ccccn1)Nc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N07 compound treatment 1.50576908E8 2.13E7 0.27 1.47156414E8 1.46E7 0.25 0.3661 0.9994 3082025 TimTec1_000293 Cc1cc(n[nH]1)c2cc(C)[nH]n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N08 compound treatment 1.55235408E8 2.6E7 0.33 1.00442091E8 -3.21E7 -0.55 -0.158 -0.2473 1617345 TimTec1_000294 CN1CCc2c(C1)c(NCCO)nc3[nH]nc(N)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N09 compound treatment 1.54912755E8 2.57E7 0.32 1.22208672E8 -1.03E7 -0.18 0.1026 0.2792 1226159 TimTec1_000295 C(Cc1ccncc1)Nc2ccc(OCc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N10 compound treatment 1.70542658E8 4.13E7 0.52 1.77398171E8 4.49E7 0.77 0.9093 0.9817 3210124 TimTec1_000296 COc1ccc2c(C)nc(N/C(=N/C(=O)C)/N)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N11 compound treatment 1.3194472E8 2700000.0 0.03 1.40457117E8 7910000.0 0.14 0.1197 0.8577 1294429 TimTec1_000297 CC(=O)Nc1c(oc2ccc(Br)cc12)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N12 compound treatment 1.23117178E8 -6120000.0 -0.08 8.742626E7 -4.51E7 -0.77 -0.6005 -0.7736 3210125 TimTec1_000298 CC1(C)Cc2c(C#N)c(=S)[nH]c(N3CCOCC3)c2CS1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N13 compound treatment 1.36478362E8 7240000.0 0.09 1.30925315E8 -1620000.0 -0.03 0.0446 0.4696 1155921 TimTec1_000299 N#CC(CCN1CCN(CC1)c2ccccc2)(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N14 compound treatment 1.44207574E8 1.5E7 0.19 1.52314628E8 1.98E7 0.34 0.372 0.9614 1441186 TimTec1_000300 C1CCC(CC1)c2nnc(o2)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N15 compound treatment 1.49284466E8 2.0E7 0.25 1.40374974E8 7830000.0 0.13 0.2726 0.9566 3210126 TimTec1_000301 CCC(C)C1=NN(C(=O)c2ccccc2)C(O)(C1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N16 compound treatment 1.42132939E8 1.29E7 0.16 9.3235168E7 -3.93E7 -0.67 -0.3615 -0.5223 3082032 TimTec1_000302 Cc1ccc(cc1)c2ccc(OC(=O)c3ccccc3F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N17 compound treatment 1.42176835E8 1.29E7 0.16 1.40633049E8 8090000.0 0.14 0.2126 0.9969 1424431 TimTec1_000303 CC1=CC(C)(C)N(Cc2ccccc2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N18 compound treatment 1.56542943E8 2.73E7 0.34 1.49005957E8 1.65E7 0.28 0.4414 0.9953 3081117 TimTec1_000304 Fc1ccc(/N=C/c2ccc(OC(=O)c3cccs3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N19 compound treatment 1.27345709E8 -1900000.0 -0.02 1.30518108E8 -2030000.0 -0.03 -0.0414 -0.983 3210127 TimTec1_000305 CC(C)C(=O)N1c2ccc(C)cc2-c3c(ssc3=S)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N20 compound treatment 1.33275899E8 4030000.0 0.05 1.53102242E8 2.06E7 0.35 0.2846 0.8006 3081119 TimTec1_000306 CCOc1cc(/C=C/2\SCOC2=O)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N21 compound treatment 1.19731844E8 -9510000.0 -0.12 1.32469885E8 -75900.0 0.0 -0.0853 -0.7148 1693566 TimTec1_000307 CCOC(=O)c1c(C)n(C)c2ccc(O)c(c12)S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N22 compound treatment 1.3432911E8 5090000.0 0.06 1.35253058E8 2710000.0 0.05 0.0779 0.9876 1465551 TimTec1_000308 Fc1ccc(CC(=O)NC2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N23 mock treatment 1.31527131E8 2290000.0 0.03 1.34111149E8 1570000.0 0.03 0.0392 0.9994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 N24 mock treatment 1.24896363E8 -4340000.0 -0.05 1.34264704E8 1720000.0 0.03 -0.0177 -0.2863 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O01 compound treatment 3.2766273E7 -9.65E7 -1.21 1.04925517E8 -2.76E7 -0.47 -1.1901 -0.9159 1586093 TimTec1_000309 OC1(N(C(=O)Nc2ccccc21)c3ccccc3)C(=O)N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O02 compound treatment 4.873824E7 -8.05E7 -1.01 1.08322211E8 -2.42E7 -0.41 -1.0073 -0.9227 1502323 TimTec1_000310 Nc1nc2CCCc2c(c1C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O03 compound treatment 5.984141E7 -6.94E7 -0.87 1.05667325E8 -2.69E7 -0.46 -0.9409 -0.9556 3210128 TimTec1_000311 NC(=N)NS(=O)(=O)c1ccc(NC(=S)NC(=O)/C=C/c2ccc(F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O04 compound treatment 1.02508894E8 -2.67E7 -0.34 1.10345924E8 -2.22E7 -0.38 -0.5058 -0.9981 1176923 TimTec1_000312 C[N+](C)(CCC#N)Cc1cccc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O05 compound treatment 1.04876536E8 -2.44E7 -0.31 1.07616908E8 -2.49E7 -0.43 -0.5179 -0.9866 3081123 TimTec1_000313 S=C(SN1CCOCC1)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O06 compound treatment 1.21038896E8 -8200000.0 -0.1 1.28649784E8 -3900000.0 -0.07 -0.1199 -0.978 1002693 TimTec1_000314 COC1OC2COC(OC2C(O)C1O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O07 compound treatment 1.2520843E8 -4030000.0 -0.05 1.31331289E8 -1210000.0 -0.02 -0.0505 -0.9228 1507393 TimTec1_000315 CCCOC(=S)NC1OCC(OC(=O)C)C(OC(=O)C)C1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O08 compound treatment 1.23190428E8 -6050000.0 -0.08 1.23855063E8 -8690000.0 -0.15 -0.1589 -0.9512 3081125 TimTec1_000316 C(c1ccccc1)c2ccc[n+](Cc3ccccn3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O09 compound treatment 1.04278937E8 -2.5E7 -0.31 1.1305158E8 -1.95E7 -0.33 -0.4574 -0.9995 3210129 TimTec1_000317 Cc1cc(C)n(n1)C(=O)COc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O10 compound treatment 9.615483E7 -3.31E7 -0.42 1.04707127E8 -2.78E7 -0.48 -0.6305 -0.9976 1676440 TimTec1_000318 CC12CCC3C(CC=C4CC(CCC34C)OC5CCCCO5)C2CCC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O11 compound treatment 9.7582648E7 -3.17E7 -0.4 1.14357521E8 -1.82E7 -0.31 -0.501 -0.9927 1921096 TimTec1_000319 O=C1NC(=O)C2(COC(OC2)c3ccccc3)S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O12 compound treatment 9.1209781E7 -3.8E7 -0.48 1.04336987E8 -2.82E7 -0.48 -0.6788 -1.0 3081128 TimTec1_000320 COc1ccc(/C=C/C(=O)NCc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O13 compound treatment 9.2231907E7 -3.7E7 -0.46 1.12289871E8 -2.03E7 -0.35 -0.5735 -0.9897 3081129 TimTec1_000321 COc1nonc1NC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O14 compound treatment 9.6532705E7 -3.27E7 -0.41 1.26783166E8 -5760000.0 -0.1 -0.3599 -0.8528 1215803 TimTec1_000322 CN(C)CCSc1nc2ccccc2c(=O)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O15 compound treatment 1.08063865E8 -2.12E7 -0.27 1.25270227E8 -7280000.0 -0.12 -0.2759 -0.9404 1134169 TimTec1_000323 COc1ccc(c2nc3nnc(C)n3[nH]2)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O16 compound treatment 8.9221531E7 -4.0E7 -0.5 1.14597943E8 -1.79E7 -0.31 -0.5722 -0.9722 1165035 TimTec1_000324 CCOC(=O)c1c(CN2CCCCC2)n(c3ccccc3)c4ccc(OC(=O)C)cc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O17 compound treatment 8.9023207E7 -4.02E7 -0.5 1.08071856E8 -2.45E7 -0.42 -0.653 -0.9957 3210130 TimTec1_000325 CC(=O)Nc1ccc(/N=C/c2ccc(cc2)N3CCOCC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O18 compound treatment 9.1334499E7 -3.79E7 -0.48 1.24146314E8 -8400000.0 -0.14 -0.4379 -0.8815 1656585 TimTec1_000326 OC(=O)C(Cc1ccsc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O19 compound treatment 9.8252425E7 -3.1E7 -0.39 1.15553614E8 -1.7E7 -0.29 -0.4806 -0.9898 3081133 TimTec1_000327 CC1(C)CC(=O)C(=CNC(CO)(CO)CO)C(=O)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O20 compound treatment 9.1829636E7 -3.74E7 -0.47 1.20359666E8 -1.22E7 -0.21 -0.4794 -0.9334 3210131 TimTec1_000328 CCOC(=O)c1c(CNC(C)C)oc2ccc(OC)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O21 compound treatment 8.8331477E7 -4.09E7 -0.51 1.06439919E8 -2.61E7 -0.45 -0.6789 -0.9976 3210132 TimTec1_000329 Cc1ccc(C)c(c1)[C@H]2[C@@H](N3C(C=Cc4ccccc34)C2(C#N)C#N)C(=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O22 compound treatment 8.9086027E7 -4.02E7 -0.5 1.18009963E8 -1.45E7 -0.25 -0.5321 -0.9471 1145302 TimTec1_000330 CCOC(=O)c1c(C)n(C2CCCCC2)c3ccc(O)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O23 mock treatment 9.3860098E7 -3.54E7 -0.44 1.14881802E8 -1.77E7 -0.3 -0.5277 -0.9825 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 O24 mock treatment 9.5598511E7 -3.36E7 -0.42 1.1844572E8 -1.41E7 -0.24 -0.4691 -0.9649 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P01 compound treatment 1.11964123E8 -1.73E7 -0.22 1.18919163E8 -1.36E7 -0.23 -0.3182 -0.9993 1004729 TimTec1_000331 COC(=O)c1ccccc1C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P02 compound treatment 1.10521345E8 -1.87E7 -0.23 1.12957024E8 -1.96E7 -0.34 -0.4032 -0.9848 3210133 TimTec1_000332 O=C(Oc1cc(OC(=O)c2ccco2)cc(OC(=O)c3ccco3)c1)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P03 compound treatment 1.05349308E8 -2.39E7 -0.3 1.050275E8 -2.75E7 -0.47 -0.545 -0.9762 3081813 TimTec1_000333 CCOC(=O)Cc1c(SC)c2ccccc2n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P04 compound treatment 1.12541577E8 -1.67E7 -0.21 1.24782316E8 -7760000.0 -0.13 -0.2421 -0.9759 3081814 TimTec1_000334 CCN(CC)CCOc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P05 compound treatment 1.17066966E8 -1.22E7 -0.15 8.5117494E7 -4.74E7 -0.81 -0.6821 -0.8256 3210134 TimTec1_000335 O=C(Cc1ccccc1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P06 compound treatment 9.5826926E7 -3.34E7 -0.42 1.02676109E8 -2.99E7 -0.51 -0.6579 -0.9951 1158366 TimTec1_000336 O=C(Nc1ccccc1)C(=S)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P07 compound treatment 1.05485397E8 -2.38E7 -0.3 1.07273864E8 -2.53E7 -0.43 -0.5166 -0.9835 1365315 TimTec1_000337 CCOC(=O)c1c(COC(=O)C)n(C)c2cc(Br)c(OC)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P08 compound treatment 1.14726652E8 -1.45E7 -0.18 1.14400354E8 -1.81E7 -0.31 -0.3484 -0.9676 1268733 TimTec1_000338 Nc1c(N2CCN(CC2)c3ccccc3)c4ccccc4oc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P09 compound treatment 1.13621061E8 -1.56E7 -0.2 1.08068932E8 -2.45E7 -0.42 -0.4348 -0.9401 1047274 TimTec1_000339 CC(=O)Nc1ccc(OCc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P10 compound treatment 1.06616897E8 -2.26E7 -0.28 1.02204037E8 -3.03E7 -0.52 -0.5679 -0.9596 1459196 TimTec1_000340 CCSc1nnc-2c(OC3(Nc4ccccc42)C(=O)Nc5ccc(Br)cc53)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P11 compound treatment 1.1625742E8 -1.3E7 -0.16 1.13174823E8 -1.94E7 -0.33 -0.3496 -0.9464 1347458 TimTec1_000341 CCOC(=O)c1oc2ccccc2c1NC(=O)CCN3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P12 compound treatment 1.19430493E8 -9810000.0 -0.12 1.1389471E8 -1.87E7 -0.32 -0.3128 -0.9141 1693186 TimTec1_000342 Cc1nn2c(=O)c3CCCc3[nH]c2c1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P13 compound treatment 1.15526934E8 -1.37E7 -0.17 1.17158301E8 -1.54E7 -0.26 -0.3079 -0.9787 1228757 TimTec1_000343 CC1(C)CC(=O)c2c(c([nH]c2C1)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P14 compound treatment 1.17527095E8 -1.17E7 -0.15 1.28711742E8 -3830000.0 -0.07 -0.1503 -0.934 3081883 TimTec1_000344 NCCCc1nc2cc3sc(CCCN)nc3cc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P15 compound treatment 1.10315809E8 -1.89E7 -0.24 1.32035996E8 -510000.0 -0.01 -0.174 -0.7326 1650512 TimTec1_000345 CC1=NN(C(=O)Cc2ccccc2)C(O)(C1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P16 compound treatment 1.0253396E8 -2.67E7 -0.34 1.20710967E8 -1.18E7 -0.2 -0.3802 -0.971 3081885 TimTec1_000346 N#Cc1ccc(C#N)c(c1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P17 compound treatment 1.05908102E8 -2.33E7 -0.29 1.13005547E8 -1.95E7 -0.33 -0.4435 -0.9978 3081886 TimTec1_000347 Cc1ccc(cc1)C2=C/C(=C/3\OC(=O)c4ccccc34)/C(=O)O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P18 compound treatment 1.08006343E8 -2.12E7 -0.27 1.17335237E8 -1.52E7 -0.26 -0.3725 -0.9999 3210253 TimTec1_000348 COC(=O)NC(Nc1ccccc1C(F)(F)F)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P19 compound treatment 1.17207054E8 -1.2E7 -0.15 1.29518073E8 -3030000.0 -0.05 -0.1434 -0.8984 1111738 TimTec1_000349 Cc1nc(NC(=N)N)nc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P20 compound treatment 1.0225396E8 -2.7E7 -0.34 1.25509741E8 -7040000.0 -0.12 -0.3246 -0.9032 1449841 TimTec1_000350 OC(=O)CCN1C(=O)C2C(C3c4ccccc4C2c5ccccc35)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P21 compound treatment 9.484547E7 -3.44E7 -0.43 1.18495173E8 -1.41E7 -0.24 -0.4752 -0.9619 1530469 TimTec1_000351 O=C(CSc1nc2ccccc2s1)NC3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P22 compound treatment 9.3813273E7 -3.54E7 -0.44 1.22873874E8 -9670000.0 -0.17 -0.4313 -0.9095 1494539 TimTec1_000352 CCCN(CCC)C(=O)c1cnn(c1NC(=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P23 mock treatment 1.01486702E8 -2.78E7 -0.35 1.20439612E8 -1.21E7 -0.21 -0.3927 -0.9693 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2063 P24 mock treatment 9.7660399E7 -3.16E7 -0.4 1.22619366E8 -9930000.0 -0.17 -0.4003 -0.9286 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A01 compound treatment 1.08530018E8 -1.1E7 -0.14 1.35609549E8 -4400000.0 -0.08 -0.1504 -0.9598 3081891 TimTec1_000353 CCc1ccc(/C=C/2\C(=NN(C2=O)c3ccccc3)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A02 compound treatment 1.03646072E8 -1.58E7 -0.2 1.27097048E8 -1.29E7 -0.22 -0.2967 -0.9986 3210254 TimTec1_000354 O=C/1NC(=S)S\C1=C\c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A03 compound treatment 1.25690565E8 6210000.0 0.08 1.45731346E8 5730000.0 0.1 0.1244 0.9935 3081893 TimTec1_000355 CCOC(=O)c1sc2cc(OC)ccc2c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A04 compound treatment 1.15836897E8 -3650000.0 -0.05 1.37523129E8 -2480000.0 -0.04 -0.0624 -0.9993 1428363 TimTec1_000356 CCc1c(C)sc(NC(=O)C2CC3CCC2C3)c1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A05 compound treatment 1.29559344E8 1.01E7 0.13 1.47895868E8 7890000.0 0.14 0.1849 0.9995 3081895 TimTec1_000357 Cc1ccc(C)[n+](CNC(=O)c2ccc(Cl)cc2Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A06 compound treatment 1.32575505E8 1.31E7 0.16 1.56640635E8 1.66E7 0.28 0.3175 0.9658 1573927 TimTec1_000358 CCOc1ccc(cc1)C(=O)Nc2cc(C)ccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A07 compound treatment 1.30253416E8 1.08E7 0.14 1.50707459E8 1.07E7 0.18 0.2251 0.9888 1174870 TimTec1_000359 OC(=O)c1ccccc1SC(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A08 compound treatment 1.33989305E8 1.45E7 0.18 1.49510698E8 9510000.0 0.16 0.2437 0.9984 3210255 TimTec1_000360 C/C(=N\N)/c1ccc2ccccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A09 compound treatment 1.25930428E8 6450000.0 0.08 1.45239612E8 5230000.0 0.09 0.1205 0.9987 3210256 TimTec1_000361 OC(=O)/C=C/c1ccc(cc1)S(=O)(=O)Nc2cccc(c2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A10 compound treatment 1.0103447E8 -1.84E7 -0.23 1.43147434E8 3140000.0 0.05 -0.1256 -0.5287 1008686 TimTec1_000362 OC(=O)c1cncc(c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A11 compound treatment 1.24393897E8 4910000.0 0.06 1.53536242E8 1.35E7 0.23 0.2073 0.8651 1637875 TimTec1_000363 Cc1oc2ccccc2c1c3ccc4ccccc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A12 compound treatment 1.32049243E8 1.26E7 0.16 1.50873354E8 1.09E7 0.19 0.243 0.9966 1629100 TimTec1_000364 COc1ccc2nc(C)cc(Nc3ccccc3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A13 compound treatment 1.18813294E8 -670000.0 -0.01 1.4302837E8 3020000.0 0.05 0.0306 0.5846 3081900 TimTec1_000365 O=C(Oc1nc2ccccc2s1)c3ccccc3C(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A14 compound treatment 1.3279949E8 1.33E7 0.17 1.52680885E8 1.27E7 0.22 0.2715 0.9917 1265013 TimTec1_000366 COc1ccc(OCC(O)CN2CCN(C)CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A15 compound treatment 1.27995394E8 8510000.0 0.11 1.54533153E8 1.45E7 0.25 0.2514 0.9287 3081958 TimTec1_000367 Cc1nn(C)cc1C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A16 compound treatment 1.30489205E8 1.1E7 0.14 1.46717767E8 6710000.0 0.11 0.1789 0.9958 3210257 TimTec1_000368 O=C(NCCOc1ccccc1Cc2ccccc2)c3ccc4CCc5cccc3c54 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A17 compound treatment 1.29397323E8 9910000.0 0.12 1.42311415E8 2310000.0 0.04 0.1159 0.8879 1435378 TimTec1_000369 O=C(NC1CCCCCCC1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A18 compound treatment 1.31838434E8 1.24E7 0.15 1.56938921E8 1.69E7 0.29 0.3146 0.957 1651254 TimTec1_000370 Clc1ccc(CCNC(=O)C(c2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A19 compound treatment 1.2594868E8 6470000.0 0.08 1.41995768E8 1990000.0 0.03 0.0814 0.9258 3210258 TimTec1_000371 COC(=O)C1=C(C)NC(=S)NC1c2cn(nc2c3cccs3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A20 compound treatment 1.30315573E8 1.08E7 0.14 1.46794644E8 6790000.0 0.12 0.1783 0.997 1199491 TimTec1_000372 O=C(CNc1ccc(Cc2ccncc2)cc1)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A21 compound treatment 1.37089649E8 1.76E7 0.22 1.4998888E8 9980000.0 0.17 0.277 0.992 1401884 TimTec1_000373 C(OC1CCCCC1)C2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A22 compound treatment 1.43666786E8 2.42E7 0.3 1.21460096E8 -1.85E7 -0.32 -0.01 -0.0227 1357135 TimTec1_000374 Cc1nnc(SCC(=O)N2CCOCC2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A23 mock treatment 1.3251455E8 1.3E7 0.16 1.48546982E8 8540000.0 0.15 0.219 0.9985 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 A24 mock treatment 9.5150471E7 -2.43E7 -0.31 1.5444554E8 1.44E7 0.25 -0.0411 -0.1045 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B01 compound treatment 1.28617013E8 9130000.0 0.11 1.2655828E8 -1.34E7 -0.23 -0.0817 -0.3179 3210259 TimTec1_000375 CC(NC(=O)CSc1nnc(c2cccc(F)c2)n1c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B02 compound treatment 1.24472165E8 4990000.0 0.06 1.40972099E8 967000.0 0.02 0.056 0.8644 1231283 TimTec1_000376 O=C(C1=NN(C2C1C(=O)N(C2=O)c3ccccc3)c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B03 compound treatment 1.57331163E8 3.78E7 0.47 1.24993502E8 -1.5E7 -0.26 0.154 0.2853 1268796 TimTec1_000377 Nc1nonc1C(=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B04 compound treatment 1.29491852E8 1.0E7 0.13 1.60796608E8 2.08E7 0.36 0.3404 0.9021 1721792 TimTec1_000378 Cc1ccc(cc1)C(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B05 compound treatment 1.35732552E8 1.62E7 0.2 1.01507225E8 -3.85E7 -0.66 -0.3219 -0.4666 3081967 TimTec1_000379 CCN1C(=O)/C(=c\2/sc3nc4ccccc4n3c2=O)/c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B06 compound treatment 1.28420373E8 8940000.0 0.11 9.0744809E7 -4.93E7 -0.84 -0.517 -0.6077 3210260 TimTec1_000380 CN(C)/C=C/c1cc-2c(cn1)C(=O)c3ccccc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B07 compound treatment 1.33399966E8 1.39E7 0.17 8.8837954E7 -5.12E7 -0.88 -0.4959 -0.5552 1780211 TimTec1_000381 CCN1CCc2c(C1)sc3[nH]c(=S)[nH]c(=S)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B08 compound treatment 1.43140106E8 2.37E7 0.3 9.2147623E7 -4.79E7 -0.82 -0.3694 -0.424 3210261 TimTec1_000382 COC(=O)C1=NNC2(C)C1C(=O)N(C2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B09 compound treatment 1.42948954E8 2.35E7 0.29 9.3453439E7 -4.66E7 -0.8 -0.3553 -0.4183 3081970 TimTec1_000383 CC1(C)CC(=O)N=C(Nc2ccc(Br)cc2)C(=O)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B10 compound treatment 1.43834576E8 2.44E7 0.31 9.8797303E7 -4.12E7 -0.71 -0.2828 -0.3679 3210262 TimTec1_000384 CCC1(NN(C(=S)N1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B11 compound treatment 1.0175271E8 -1.77E7 -0.22 9.7750813E7 -4.23E7 -0.72 -0.6687 -0.8837 3210263 TimTec1_000385 CN(C)CCSc1nc(cc(c1C#N)c2ccc(Cl)cc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B12 compound treatment 8.4365187E7 -3.51E7 -0.44 1.418147E8 1810000.0 0.03 -0.2896 -0.6558 1634534 TimTec1_000386 Cc1cccc(c1)C(=O)N(CCN2C(=O)c3ccccc3C2=O)c4cccc5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B13 compound treatment 1.41935195E8 2.25E7 0.28 1.41560549E8 1560000.0 0.03 0.218 0.7705 1575191 TimTec1_000387 CCN(CC)S(=O)(=O)c1cc(ccc1C)c2nnc(o2)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B14 compound treatment 9.4723856E7 -2.48E7 -0.31 1.61481536E8 2.15E7 0.37 0.0403 0.0838 1606248 TimTec1_000388 CN(c1ccc(cc1)C(=O)N2CCCCC2)S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B15 compound treatment 1.34576262E8 1.51E7 0.19 1.56042907E8 1.6E7 0.27 0.328 0.9835 3210264 TimTec1_000389 OC(=O)C(CC(=O)c1ccc(Br)cc1)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B16 compound treatment 1.22432719E8 2950000.0 0.04 7.9503418E7 -6.05E7 -1.04 -0.7062 -0.6814 1631485 TimTec1_000390 Brc1ccccc1OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B17 compound treatment 1.2869441E8 9210000.0 0.12 1.52133575E8 1.21E7 0.21 0.2285 0.9617 1246627 TimTec1_000391 OC(=O)C(CC(=O)c1ccc(cc1)C2CCCCC2)n3ccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B18 compound treatment 1.50248267E8 3.08E7 0.39 1.57562534E8 1.76E7 0.3 0.4854 0.9924 1679013 TimTec1_000392 OC(=O)CCn1c(=O)n(CCC(=O)O)c2c(Cl)cc(Cl)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B19 compound treatment 1.05470983E8 -1.4E7 -0.18 9.6713124E7 -4.33E7 -0.74 -0.6483 -0.8512 3082038 TimTec1_000393 Oc1ccccc1/C=N/n2c(nc3ccccc3c2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B20 compound treatment 1.37254463E8 1.78E7 0.22 9.1627318E7 -4.84E7 -0.83 -0.4279 -0.499 1477092 TimTec1_000394 CC(=O)Oc1ccc(cc1)C(=O)Nc2ccc(F)cc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B21 compound treatment 8.3444659E7 -3.6E7 -0.45 1.15510697E8 -2.45E7 -0.42 -0.6162 -0.9993 1663115 TimTec1_000395 CCOC(=O)c1c(C)[nH]c(=S)c(C#N)c1c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B22 compound treatment 1.28624183E8 9140000.0 0.11 1.15630007E8 -2.44E7 -0.42 -0.214 -0.4945 1283576 TimTec1_000396 CC(=O)Oc1ccccc1C(=O)N2CCN(CC2)c3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B23 mock treatment 1.42467687E8 2.3E7 0.29 1.47209222E8 7200000.0 0.12 0.2911 0.9282 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 B24 mock treatment 1.33932274E8 1.44E7 0.18 1.516767E8 1.17E7 0.2 0.2694 0.9988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C01 compound treatment 1.01868239E8 -1.76E7 -0.22 1.39026505E8 -979000.0 -0.02 -0.1681 -0.7585 1380400 TimTec1_000397 O=C(Nc1sc2CCCCCc2c1C(=O)N3CCOCC3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C02 compound treatment 1.20220177E8 737000.0 0.01 1.3893876E8 -1070000.0 -0.02 -0.0064 -0.3115 1651805 TimTec1_000398 CC(C(Cc1cc(C)cc(C)c1)c2nc3ccccc3[nH]2)c4nc5ccccc5[nH]4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C03 compound treatment 1.01205434E8 -1.83E7 -0.23 1.33988884E8 -6020000.0 -0.1 -0.235 -0.9348 1188845 TimTec1_000399 O=C(N1CCN(CC1)C(c2ccccc2)c3ccccc3)c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C04 compound treatment 1.14450671E8 -5030000.0 -0.06 1.33736568E8 -6270000.0 -0.11 -0.1205 -0.968 1525346 TimTec1_000400 NC(=O)c1c(NC(=O)C2CC2)sc3CCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C05 compound treatment 1.22534709E8 3050000.0 0.04 1.46924518E8 6920000.0 0.12 0.1108 0.8903 3210265 TimTec1_000401 CC1=NN(C(=O)C1/C=N/C2CCS(=O)(=O)C2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C06 compound treatment 1.18547606E8 -936000.0 -0.01 1.38893765E8 -1110000.0 -0.02 -0.0218 -0.9731 1333714 TimTec1_000402 O=C(NC1CCCC1)C(Sc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C07 compound treatment 1.205742E8 1090000.0 0.01 1.48546471E8 8540000.0 0.15 0.1131 0.7699 1642658 TimTec1_000403 O=C(COCC(=O)c1ccccc1)Sc2nc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C08 compound treatment 1.2027675E8 793000.0 0.01 1.42570834E8 2570000.0 0.04 0.0381 0.8459 1608693 TimTec1_000404 CCN(CC)C(=O)c1sc(N)c(C#N)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C09 compound treatment 5.2989442E7 -6.65E7 -0.83 7.0374101E7 -6.96E7 -1.19 -1.4327 -0.9848 1606859 TimTec1_000405 COc1ccc(cc1)c2nn(C)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C10 compound treatment 1.18127736E8 -1360000.0 -0.02 1.48358556E8 8350000.0 0.14 0.0891 0.6186 3082046 TimTec1_000406 COC(=O)c1csc(C(=O)OC)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C11 compound treatment 1.1926633E8 -217000.0 0.0 1.44470162E8 4460000.0 0.08 0.0521 0.6815 3210382 TimTec1_000407 CC(=O)Oc1ccccc1OCc2nn(C)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C12 compound treatment 1.21554458E8 2070000.0 0.03 1.35774791E8 -4230000.0 -0.07 -0.0328 -0.4268 1715694 TimTec1_000408 CCOc1ccc(Oc2cc(NC(=O)c3ccc(F)cc3)cc(NC(=O)c4ccc(F)cc4)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C13 compound treatment 1.22305837E8 2820000.0 0.04 1.45466427E8 5460000.0 0.09 0.0911 0.9117 3082048 TimTec1_000409 O=C(CCN1CCOCC1)N/C=N\c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C14 compound treatment 1.31059211E8 1.16E7 0.15 1.44510005E8 4500000.0 0.08 0.1572 0.9561 1388427 TimTec1_000410 COc1ccc(cc1)c2ccc(o2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C15 compound treatment 1.12420237E8 -7060000.0 -0.09 1.37283168E8 -2720000.0 -0.05 -0.0956 -0.955 1724239 TimTec1_000411 O=C(CCc1ccccc1)NCCN2CCN(CC2)C(=O)CCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C16 compound treatment 1.2579019E8 6310000.0 0.08 1.44280046E8 4270000.0 0.07 0.1077 0.9992 3082050 TimTec1_000412 COC(=O)NCCOc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C17 compound treatment 1.16887075E8 -2600000.0 -0.03 1.38588679E8 -1420000.0 -0.02 -0.0402 -0.9894 1126232 TimTec1_000413 O=C(NCCC(c1ccccc1)c2ccccc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C18 compound treatment 1.2364829E8 4160000.0 0.05 1.39012102E8 -993000.0 -0.02 0.0249 0.4536 1230497 TimTec1_000414 O=C(NCc1cccc2ccccc12)c3ccc4CCc5cccc3c54 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C19 compound treatment 1.22847428E8 3360000.0 0.04 1.44567362E8 4560000.0 0.08 0.0851 0.9583 1531449 TimTec1_000415 COc1ccccc1C(=O)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C20 compound treatment 1.25348074E8 5860000.0 0.07 1.4548582E8 5480000.0 0.09 0.1184 0.9928 1369763 TimTec1_000416 O=S(=O)(NCc1cccc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C21 compound treatment 1.30653918E8 1.12E7 0.14 1.4011264E8 107000.0 0.0 0.1004 0.7163 1183479 TimTec1_000417 C(Oc1cccc2cccnc12)C3CCCN4CCCCC34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C22 compound treatment 1.2267659E8 3190000.0 0.04 1.34038958E8 -5970000.0 -0.1 -0.0439 -0.4001 3081139 TimTec1_000418 Cc1nnc(SC(c2ccccc2)c3ccccc3)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C23 mock treatment 1.22024398E8 2540000.0 0.03 1.3330146E8 -6700000.0 -0.11 -0.0586 -0.4921 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 C24 mock treatment 1.24013704E8 4530000.0 0.06 1.39965741E8 -39500.0 0.0 0.0397 0.6986 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D01 compound treatment 1.39641653E8 2.02E7 0.25 1.46474207E8 6470000.0 0.11 0.2571 0.9314 1140783 TimTec1_000419 O=C(CSCC(=O)c1ccc(cc1)c2ccccc2)Nc3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D02 compound treatment 1.26756638E8 7270000.0 0.09 1.35185439E8 -4820000.0 -0.08 0.0062 0.0502 1615836 TimTec1_000420 NS(=O)(=O)c1ccc(CNC(=O)c2ccc(cc2)C(=O)N(C3CCCCC3)C4CCCCC4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D03 compound treatment 1.45675516E8 2.62E7 0.33 1.48446211E8 8440000.0 0.14 0.3345 0.9319 3081141 TimTec1_000421 Nc1nonc1/C(=N/O)/N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D04 compound treatment 1.27375058E8 7890000.0 0.1 1.54375074E8 1.44E7 0.25 0.2439 0.92 1613632 TimTec1_000422 COC(=O)C1CCN(CC1)S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D05 compound treatment 1.42994394E8 2.35E7 0.29 1.54095999E8 1.41E7 0.24 0.3791 0.995 3081143 TimTec1_000423 COCCN1C(=O)/C(=C/c2sccc2C)/SC1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D06 compound treatment 1.37062599E8 1.76E7 0.22 1.47248681E8 7240000.0 0.12 0.2436 0.9629 1480512 TimTec1_000424 CCOC(=O)c1[nH]c(=O)[nH]c1Cn2nc(C)cc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D07 compound treatment 1.36597851E8 1.71E7 0.21 1.19055818E8 -2.09E7 -0.36 -0.1018 -0.2435 3210383 TimTec1_000425 Cc1ccc(/C=C/C(=O)Nc2sc3CCCCc3c2C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D08 compound treatment 1.190592E8 -424000.0 -0.01 9.4913453E7 -4.51E7 -0.77 -0.5496 -0.712 1098479 TimTec1_000426 CCOC(=O)C1=NN(CC1C(=O)OC)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D09 compound treatment 1.31669638E8 1.22E7 0.15 1.05522151E8 -3.45E7 -0.59 -0.3093 -0.5072 3210384 TimTec1_000427 CC(=O)N/C(=N\C(=O)C)/c1ccc(cc1)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D10 compound treatment 1.34715101E8 1.52E7 0.19 1.42075867E8 2070000.0 0.04 0.1602 0.8242 1312411 TimTec1_000428 CC1(C)Cc2ccccc2C(=N1)C(Cc3ccccc3)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D11 compound treatment 1.25559084E8 6080000.0 0.08 1.33049008E8 -6960000.0 -0.12 -0.0303 -0.2144 1238734 TimTec1_000429 Cn1c2CCCC(=O)c2c3cc(ccc13)C4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D12 compound treatment 1.4513538E8 2.57E7 0.32 1.49443788E8 9440000.0 0.16 0.3418 0.9492 1207720 TimTec1_000430 O=C1CCC(=O)N1c2ccccc2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D13 compound treatment 1.31174478E8 1.17E7 0.15 1.49309186E8 9300000.0 0.16 0.2163 0.9992 3210385 TimTec1_000431 COc1ccc(cc1)c2cc(nc(SC/C(=N\C#N)/N)c2C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D14 compound treatment 1.37899666E8 1.84E7 0.23 1.60264215E8 2.03E7 0.35 0.4086 0.9805 3081150 TimTec1_000432 O=S(=O)(/N=c\1/cc(ss1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D15 compound treatment 1.38687078E8 1.92E7 0.24 1.62144595E8 2.21E7 0.38 0.4383 0.9761 3210386 TimTec1_000433 CCN(CC)CCCNc1nc(Cl)nc(Nc2ccc(F)cc2F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D16 compound treatment 1.46179523E8 2.67E7 0.33 1.59401423E8 1.94E7 0.33 0.4716 1.0 1665252 TimTec1_000434 CCN(CC)C(=O)COCC1CCCN2CCCCC12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D17 compound treatment 1.55476849E8 3.6E7 0.45 1.19010187E8 -2.1E7 -0.36 0.0651 0.1129 3081152 TimTec1_000435 Clc1cc(Cl)cc(NC(=N)N2CCN(Cc3ccccc3)CC2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D18 compound treatment 1.35232079E8 1.57E7 0.2 1.74217433E8 3.42E7 0.59 0.5538 0.896 3210387 TimTec1_000436 CCOC(=O)c1c(C)n[nH]c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D19 compound treatment 1.32998069E8 1.35E7 0.17 1.29800947E8 -1.02E7 -0.17 -0.0036 -0.0149 3081154 TimTec1_000437 O=C(/C=C/c1ccccc1)C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D20 compound treatment 1.37191474E8 1.77E7 0.22 1.41386166E8 1380000.0 0.02 0.1738 0.778 1277973 TimTec1_000438 CCC(C)NC(=O)c1ccc(OC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D21 compound treatment 1.26945428E8 7460000.0 0.09 1.40483297E8 478000.0 0.01 0.072 0.766 1511267 TimTec1_000439 COc1ccc(OCc2c(C#N)c3ccccc3n2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D22 compound treatment 1.40461155E8 2.1E7 0.26 1.53135736E8 1.31E7 0.22 0.345 0.9969 1736813 TimTec1_000440 CC(NC(=O)c1ccccc1OC(=O)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D23 mock treatment 1.27680856E8 8200000.0 0.1 1.38896289E8 -1110000.0 -0.02 0.0593 0.567 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 D24 mock treatment 1.2474141E8 5260000.0 0.07 1.32082844E8 -7920000.0 -0.14 -0.0493 -0.3266 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E01 compound treatment 9.9162824E7 -2.03E7 -0.25 1.13675722E8 -2.63E7 -0.45 -0.4989 -0.9636 1576550 TimTec1_000441 Brc1ccc(cc1)S(=O)(=O)N2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E02 compound treatment 1.07966355E8 -1.15E7 -0.14 1.18932939E8 -2.11E7 -0.36 -0.3572 -0.9193 1538091 TimTec1_000442 CCOc1ccc(NC(=O)CC(C)Cc2cc(C)cc(C)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E03 compound treatment 3.03374315E8 1.84E8 2.31 3.30109782E8 1.9E8 3.25 3.9322 0.9858 1380584 TimTec1_000443 Cc1ccc(o1)c2cc(C(=O)O)c3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E04 compound treatment 1.10999102E8 -8480000.0 -0.11 1.30021352E8 -9980000.0 -0.17 -0.1961 -0.974 1384234 TimTec1_000444 Cc1onc(c1C(=O)NCc2ccc(F)cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E05 compound treatment 1.15948129E8 -3540000.0 -0.04 1.26738801E8 -1.33E7 -0.23 -0.1919 -0.8295 3210388 TimTec1_000445 Cc1nn(c(O)c1/C=C/2\SC(=S)N(Cc3ccccc3)C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E06 compound treatment 1.1237485E8 -7110000.0 -0.09 1.1814479E8 -2.19E7 -0.37 -0.3277 -0.8518 1727240 TimTec1_000446 O=C(Nc1ccc(cc1)S(=O)(=O)Nc2nccs2)C3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E07 compound treatment 1.11586075E8 -7900000.0 -0.1 1.28328254E8 -1.17E7 -0.2 -0.2114 -0.9476 1282347 TimTec1_000447 O=C(COCC(=O)c1ccccc1)Sc2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E08 compound treatment 1.1492188E8 -4560000.0 -0.06 1.41535439E8 1530000.0 0.03 -0.0219 -0.3486 1626029 TimTec1_000448 CC(NC(=O)c1ccccc1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E09 compound treatment 1.1752782E8 -1960000.0 -0.02 9.6652413E7 -4.34E7 -0.74 -0.5421 -0.7301 3081750 TimTec1_000449 Cc1ccc(OCc2nn(C)c3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E10 compound treatment 9.8822954E7 -2.07E7 -0.26 1.26127403E8 -1.39E7 -0.24 -0.3512 -0.9991 3081752 TimTec1_000450 Cn1ncc(Br)c1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E11 compound treatment 1.15071358E8 -4410000.0 -0.06 1.35856377E8 -4150000.0 -0.07 -0.0894 -0.9924 1483987 TimTec1_000451 O=C(Cc1nc2ccccc2[nH]1)Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E12 compound treatment 1.23913781E8 4430000.0 0.06 1.15195094E8 -2.48E7 -0.42 -0.261 -0.6094 1161165 TimTec1_000452 OC(=O)c1cc2cccc(c2cc1O)S(=O)(=O)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E13 compound treatment 1.19161595E8 -322000.0 0.0 1.17414815E8 -2.26E7 -0.39 -0.2763 -0.7144 3081755 TimTec1_000453 O=C(N/C=N\c1cccnc1)C2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E14 compound treatment 1.23028364E8 3540000.0 0.04 1.28375277E8 -1.16E7 -0.2 -0.1093 -0.5359 1290467 TimTec1_000454 CCCc1nc(c(NC)o1)S(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E15 compound treatment 1.06973992E8 -1.25E7 -0.16 1.36459939E8 -3550000.0 -0.06 -0.1539 -0.9146 1210563 TimTec1_000455 Cc1cc(C)c(c(C)c1)n2cccc2CN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E16 compound treatment 1.19636927E8 154000.0 0.0 1.31168409E8 -8840000.0 -0.15 -0.1056 -0.698 1600581 TimTec1_000456 O=C(NCc1ccc2OCOc2c1)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E17 compound treatment 1.23930612E8 4450000.0 0.06 9.9180731E7 -4.08E7 -0.7 -0.4547 -0.6486 3210389 TimTec1_000457 Clc1ccccc1c2ccc(/C=C/3\SC(=S)N(CC4CCCO4)C3=O)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E18 compound treatment 1.25800562E8 6320000.0 0.08 1.40041109E8 35800.0 0.0 0.0565 0.7126 1166878 TimTec1_000458 O=C(NCc1cccc2ccccc12)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E19 compound treatment 1.17520373E8 -1960000.0 -0.02 1.67709398E8 2.77E7 0.47 0.3179 0.6695 1409245 TimTec1_000459 Clc1ccc(OCC(=O)OCC2CCCN3CCCCC23)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E20 compound treatment 1.15319993E8 -4160000.0 -0.05 1.32001022E8 -8000000.0 -0.14 -0.1338 -0.9126 1120094 TimTec1_000460 Cc1ccc(CSc2nnc(N)s2)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E21 compound treatment 1.1838496E8 -1100000.0 -0.01 1.32601643E8 -7400000.0 -0.13 -0.0994 -0.7794 1262423 TimTec1_000461 O=C1CCC(=O)N1OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E22 compound treatment 8.4463207E7 -3.5E7 -0.44 9.1536653E7 -4.85E7 -0.83 -0.8973 -0.9558 3210390 TimTec1_000462 COc1ccc(cc1)c2nnc(SCC(=O)CSc3nnc([nH]3)c4ccc(OC)cc4)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E23 mock treatment 1.11370658E8 -8110000.0 -0.1 7.4578117E7 -6.54E7 -1.12 -0.8639 -0.7682 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 E24 mock treatment 1.12174417E8 -7310000.0 -0.09 1.41951879E8 1950000.0 0.03 -0.0413 -0.4231 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F01 compound treatment 9.8862212E7 -2.06E7 -0.26 1.05099183E8 -3.49E7 -0.6 -0.6054 -0.9298 3081761 TimTec1_000463 C(Sc1nnc(c2ccco2)n1c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F02 compound treatment 1.05508553E8 -1.4E7 -0.18 8.5814219E7 -5.42E7 -0.93 -0.7799 -0.8261 1189560 TimTec1_000464 O=C(NCCc1c[nH]c2ccccc12)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F03 compound treatment 1.07523708E8 -1.2E7 -0.15 9.0513182E7 -4.95E7 -0.85 -0.7051 -0.8196 3210512 TimTec1_000465 COc1ccc(cc1COc2cccc(Cl)c2)C3C4C(NN=C4C)OC(=C3C#N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F04 compound treatment 1.26294349E8 6810000.0 0.09 9.1583148E7 -4.84E7 -0.83 -0.5257 -0.6309 3081764 TimTec1_000466 O=c1/c(=C/c2ccc(cc2)N3CCOCC3)/sc4nc5ccccc5n14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F05 compound treatment 8.0655848E7 -3.88E7 -0.49 7.7441959E7 -6.26E7 -1.07 -1.1017 -0.9364 1511275 TimTec1_000467 CCOC(=O)C1=C(NC(=O)c2cccs2)C(CC=C)C(=S)S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F06 compound treatment 1.08607566E8 -1.09E7 -0.14 1.27706249E8 -1.23E7 -0.21 -0.2453 -0.9779 1440881 TimTec1_000468 O=C(CNS(=O)(=O)c1ccccc1)Oc2ccc3ccc(=O)oc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F07 compound treatment 1.23211643E8 3730000.0 0.05 1.31422357E8 -8580000.0 -0.15 -0.0708 -0.4593 3210513 TimTec1_000469 Cc1c(NC(=O)/C=C/c2ccc(Cl)cc2Cl)c(=O)n(c3ccccc3)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F08 compound treatment 1.2027446E8 791000.0 0.01 1.36507616E8 -3500000.0 -0.06 -0.0353 -0.582 1518488 TimTec1_000470 CCOC(=O)N1CCN(CC1)C(=O)c2ccc3nc(c4ccccc4)c(nc3c2)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F09 compound treatment 1.12822226E8 -6660000.0 -0.08 1.23089682E8 -1.69E7 -0.29 -0.2638 -0.8754 1338448 TimTec1_000471 O=C(CCc1ccccc1)Nc2cccc(NC(=O)CCc3ccccc3)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F10 compound treatment 7.783605E7 -4.16E7 -0.52 1.29275567E8 -1.07E7 -0.18 -0.4993 -0.9016 1388176 TimTec1_000472 O=C(N1CCCCC1)c2cccc(c2)S(=O)(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F11 compound treatment 7.8579592E7 -4.09E7 -0.51 1.39052154E8 -953000.0 -0.02 -0.3744 -0.7292 1550208 TimTec1_000473 Nc1nc(N)c2sc(Nc3ccccc3)c(C#N)c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F12 compound treatment 9.7793413E7 -2.17E7 -0.27 1.27171234E8 -1.28E7 -0.22 -0.3477 -0.9944 1706746 TimTec1_000474 O=C(NCc1ccco1)c2ccccc2C(=O)c3ncc[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F13 compound treatment 1.0715919E8 -1.23E7 -0.15 9.9391256E7 -4.06E7 -0.7 -0.6009 -0.8437 1726053 TimTec1_000475 NC(=O)c1c(SCC#N)nc(cc1c2ccc(F)cc2)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F14 compound treatment 1.25150179E8 5670000.0 0.07 8.4215222E7 -5.58E7 -0.96 -0.625 -0.6527 3081820 TimTec1_000476 COC1(OC)N=C(N)C2(C#N)C3CCC(C=C3)C12C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F15 compound treatment 1.08278265E8 -1.12E7 -0.14 1.19697251E8 -2.03E7 -0.35 -0.3452 -0.9206 1570113 TimTec1_000477 CNC(=S)N(Cc1ccc(OC)cc1OC)c2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F16 compound treatment 7.4387772E7 -4.51E7 -0.57 1.38890966E8 -1110000.0 -0.02 -0.4135 -0.7305 1573637 TimTec1_000478 C[N+]12CCCCC2C(COC(=O)c3ccccn3)CCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F17 compound treatment 1.18495676E8 -988000.0 -0.01 1.40376371E8 371000.0 0.01 -0.0043 -0.3066 3210514 TimTec1_000479 Cc1ccc(cc1)C(=O)CC(NCCN2CCOCC2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F18 compound treatment 1.0446586E8 -1.5E7 -0.19 1.4155134E8 1550000.0 0.03 -0.1145 -0.6019 2120076 TimTec1_000480 Cl/C(=N\c1ccccc1)/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F19 compound treatment 7.8422184E7 -4.11E7 -0.52 8.6583433E7 -5.34E7 -0.91 -1.0109 -0.9631 3081824 TimTec1_000481 CCN(CC)C(=O)c1ccc[n+](CC(=O)N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F20 compound treatment 7.7254097E7 -4.22E7 -0.53 1.43313093E8 3310000.0 0.06 -0.3345 -0.6279 1381433 TimTec1_000482 CC(=O)Nc1ccc(cc1)C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F21 compound treatment 8.8822804E7 -3.07E7 -0.38 1.06458358E8 -3.35E7 -0.57 -0.678 -0.981 1233063 TimTec1_000483 Cc1cc(=O)oc2ccc(OCC(=O)N3CCOCC3)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F22 compound treatment 1.20584748E8 1100000.0 0.01 1.60802796E8 2.08E7 0.36 0.2615 0.734 1243176 TimTec1_000484 CC(=O)Oc1ccccc1C(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F23 mock treatment 1.15431644E8 -4050000.0 -0.05 1.32287045E8 -7720000.0 -0.13 -0.1294 -0.9138 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 F24 mock treatment 1.16396088E8 -3090000.0 -0.04 1.40125692E8 120000.0 0.0 -0.0259 -0.6685 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G01 compound treatment 8.7536431E7 -3.19E7 -0.4 1.02146292E8 -3.79E7 -0.65 -0.7416 -0.9733 1705462 TimTec1_000485 CC(=O)Nc1ccc2NC(C3CC=CC3c2c1)c4cccc(Cl)c4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G02 compound treatment 1.18192757E8 -1290000.0 -0.02 1.34240475E8 -5760000.0 -0.1 -0.0812 -0.8123 1202595 TimTec1_000486 Cc1cc(C)cc(CC(CC(=O)O)C(=O)NCc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G03 compound treatment 1.17045758E8 -2440000.0 -0.03 1.49881828E8 9880000.0 0.17 0.0979 0.57 1578135 TimTec1_000487 COc1ccc(OC)c(NC(=O)c2cccnc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G04 compound treatment 1.26093995E8 6610000.0 0.08 1.53280549E8 1.33E7 0.23 0.2193 0.9067 3081828 TimTec1_000488 FC(F)(F)c1ccccc1NC(=O)c2cnccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G05 compound treatment 1.08991694E8 -1.05E7 -0.13 1.32326469E8 -7680000.0 -0.13 -0.186 -1.0 3210515 TimTec1_000489 CCOC(=O)C1(NC(=S)N2CCOCC2)Sc3cc(C)ccc3NC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G06 compound treatment 1.27154308E8 7670000.0 0.1 1.50201216E8 1.02E7 0.17 0.1915 0.9606 1293037 TimTec1_000490 COc1ccc(NC(=O)c2cc(nc3ccccc23)c4cccs4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G07 compound treatment 1.34493092E8 1.5E7 0.19 1.61647831E8 2.16E7 0.37 0.3951 0.9507 3210516 TimTec1_000491 O=C(Cc1ccccc1)Sc2ncn[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G08 compound treatment 9.4267787E7 -2.52E7 -0.32 1.6243776E8 2.24E7 0.38 0.0479 0.0962 3210517 TimTec1_000492 CCOC(=O)c1cnn2c(cc(nc12)c3ccc(OC)cc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G09 compound treatment 1.10926246E8 -8560000.0 -0.11 9.9946847E7 -4.01E7 -0.69 -0.5608 -0.808 3081831 TimTec1_000493 Oc1ccc(Cn2nc(c3ccc(O)cc3)c4ccccc24)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G10 compound treatment 1.0403569E8 -1.54E7 -0.19 1.22168861E8 -1.78E7 -0.31 -0.3529 -0.9759 1071560 TimTec1_000494 CCOC(=O)c1sc(N)c(C(=O)OCC)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G11 compound treatment 6.9085299E7 -5.04E7 -0.63 9.0483243E7 -4.95E7 -0.85 -1.0465 -0.9896 3210518 TimTec1_000495 Cn1nc(c2ccc(Cl)cc2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G12 compound treatment 1.38758114E8 1.93E7 0.24 1.63893359E8 2.39E7 0.41 0.4601 0.9686 1169828 TimTec1_000496 Cn1nc(cc1C(=O)N2CCOCC2)C(=O)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G13 compound treatment 8.8376695E7 -3.11E7 -0.39 1.04957994E8 -3.5E7 -0.6 -0.7001 -0.9783 1636675 TimTec1_000497 O=C(Sc1cccc2ncccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G14 compound treatment 9.9418295E7 -2.01E7 -0.25 1.19946583E8 -2.01E7 -0.34 -0.4208 -0.9883 1539302 TimTec1_000498 CCCc1ccc(OCC(O)CN2CC(C)OC(C)C2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G15 compound treatment 9.3956464E7 -2.55E7 -0.32 1.63034554E8 2.3E7 0.39 0.0523 0.103 1391849 TimTec1_000499 Fc1ccccc1C(=O)NC2CCC(CC2)NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G16 compound treatment 1.26078492E8 6600000.0 0.08 1.64114354E8 2.41E7 0.41 0.3503 0.8323 3210519 TimTec1_000500 COc1ccccc1OCCNC(=O)c2ccc3CCc4cccc2c43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G17 compound treatment 1.23568887E8 4090000.0 0.05 1.47071114E8 7070000.0 0.12 0.1218 0.9269 3081837 TimTec1_000501 COCCN1C(=O)/C(=C\2/C(=O)N(OC)c3ccccc23)/SC1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G18 compound treatment 1.29790418E8 1.03E7 0.13 1.60576305E8 2.06E7 0.35 0.3404 0.9075 1286375 TimTec1_000502 O=C(NCc1cccc2ccccc12)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G19 compound treatment 1.32690931E8 1.32E7 0.17 1.52737607E8 1.27E7 0.22 0.2713 0.9908 1364575 TimTec1_000503 NCCC(=O)OCC1CCCN2CCCCC12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G20 compound treatment 1.57066629E8 3.76E7 0.47 1.63449332E8 2.34E7 0.4 0.6171 0.9968 3081904 TimTec1_000504 Cc1ccc(CSc2nc3ccccc3s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G21 compound treatment 1.33100306E8 1.36E7 0.17 1.56748506E8 1.67E7 0.29 0.3235 0.9694 1216012 TimTec1_000505 O=C(COCC1CCCN2CCCCC12)Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G22 compound treatment 1.20871194E8 1390000.0 0.02 1.40757644E8 752000.0 0.01 0.0214 0.989 1654975 TimTec1_000506 O=C(CSCC(=O)c1ccc-2c(Cc3ccccc32)c1)Nc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G23 mock treatment 1.28987658E8 9500000.0 0.12 1.48389993E8 8380000.0 0.14 0.1858 0.9957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 G24 mock treatment 1.26789545E8 7310000.0 0.09 1.50550828E8 1.05E7 0.18 0.1925 0.9506 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H01 compound treatment 1.41358707E8 2.19E7 0.27 1.70987547E8 3.1E7 0.53 0.5691 0.953 3081906 TimTec1_000507 C(Sc1nc2ccccc2s1)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H02 compound treatment 1.40522718E8 2.1E7 0.26 1.60538512E8 2.05E7 0.35 0.4352 0.99 1631930 TimTec1_000508 COc1ccc(cc1OC)c2nnc(o2)c3ccc(cc3)S(=O)(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H03 compound treatment 1.25558187E8 6070000.0 0.08 1.49936408E8 9930000.0 0.17 0.1741 0.9345 1266410 TimTec1_000509 NC1=C(C#N)C(C(=C(N)S1)C#N)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H04 compound treatment 1.31195901E8 1.17E7 0.15 9.9439458E7 -4.06E7 -0.69 -0.3871 -0.5454 1442167 TimTec1_000510 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H05 compound treatment 1.27859464E8 8380000.0 0.11 1.52302078E8 1.23E7 0.21 0.2231 0.9485 3210520 TimTec1_000511 Clc1ccc(c2ccc(/C=C(\NC(=O)c3ccccc3)/C(=O)N4CCCC4)o2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H06 compound treatment 1.33305942E8 1.38E7 0.17 1.71096319E8 3.11E7 0.53 0.4989 0.8914 1738071 TimTec1_000512 COc1ccccc1N2C(=O)c3ccc(cc3C2=O)c4nc5cc(Cl)ccc5c(=O)o4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H07 compound treatment 1.34168431E8 1.47E7 0.18 1.08853334E8 -3.12E7 -0.53 -0.2468 -0.4375 1329849 TimTec1_000513 O=C(Nc1ccc(Oc2ccccc2)cc1)C3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H08 compound treatment 1.27826378E8 8340000.0 0.1 1.61395447E8 2.14E7 0.37 0.3329 0.8742 1630279 TimTec1_000514 C(N1CCN(Cc2ccccc2)C1c3ccc4OCOc4c3)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H09 compound treatment 9.8149124E7 -2.13E7 -0.27 7.6953478E7 -6.31E7 -1.08 -0.9524 -0.8565 1681726 TimTec1_000515 NC(=O)C1C(C(=C(N)NC1=S)C#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H10 compound treatment 1.25327136E8 5840000.0 0.07 1.33310645E8 -6690000.0 -0.11 -0.0292 -0.2146 1578391 TimTec1_000516 CC(=O)OC1(CC(CN(C1)C(C)(C)C)C(C)(C)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H11 compound treatment 1.03414682E8 -1.61E7 -0.2 1.43879731E8 3870000.0 0.07 -0.0956 -0.4507 1698115 TimTec1_000517 Brc1ccc(Nc2nc(cs2)c3ccc(cc3)S(=O)(=O)N4CCCCC4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H12 compound treatment 1.41425389E8 2.19E7 0.28 1.63549847E8 2.35E7 0.4 0.4796 0.9827 1204133 TimTec1_000518 O=S(=O)(N1CCN(CC1)C(c2ccccc2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H13 compound treatment 1.2177712E8 2290000.0 0.03 1.7659572E8 3.66E7 0.63 0.4632 0.7388 1427336 TimTec1_000519 CC(C)N1CCC2(CC1)C(=C(N)NC(=C2C#N)S)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H14 compound treatment 1.36096663E8 1.66E7 0.21 1.61976226E8 2.2E7 0.38 0.4133 0.9612 1552647 TimTec1_000520 Cn1c(CN2CCCCC2)c(C#N)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H15 compound treatment 1.39308837E8 1.98E7 0.25 1.531E8 1.31E7 0.22 0.3344 0.9987 1575250 TimTec1_000521 COc1cccc(CN(C(=S)NCc2ccccc2)c3ccc(F)c(Cl)c3)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H16 compound treatment 1.38973139E8 1.95E7 0.24 1.33231084E8 -6770000.0 -0.12 0.0909 0.3359 1570436 TimTec1_000522 Oc1ccccc1C(=O)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H17 compound treatment 1.29083154E8 9600000.0 0.12 1.5974623E8 1.97E7 0.34 0.3241 0.9034 3210637 TimTec1_000523 OC(=O)C(CC(=O)c1ccc(Br)cc1)NCCc2cc3ccccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H18 compound treatment 1.1598047E8 -3500000.0 -0.04 1.57007935E8 1.7E7 0.29 0.1747 0.5936 1321027 TimTec1_000524 CCc1cccc(C)c1NC(=O)c2ccc(OC(=O)C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H19 compound treatment 8.174322E7 -3.77E7 -0.47 1.54880146E8 1.49E7 0.25 -0.1547 -0.2878 1312477 TimTec1_000525 CC1=C(C(C(=C(S)N1)C#N)c2ccncc2)C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H20 compound treatment 1.39336308E8 1.99E7 0.25 1.03210795E8 -3.68E7 -0.63 -0.2693 -0.3976 1393948 TimTec1_000526 CCCNC(=O)c1ccc(NC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H21 compound treatment 1.27441374E8 7960000.0 0.1 1.71350451E8 3.13E7 0.54 0.45 0.8245 1298760 TimTec1_000527 O=C(NCc1ccc2OCOc2c1)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H22 compound treatment 1.17788909E8 -1690000.0 -0.02 1.42631208E8 2630000.0 0.04 0.0168 0.3369 1374460 TimTec1_000528 CC(=O)Oc1ccccc1C(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H23 mock treatment 1.19413983E8 -69400.0 0.0 1.62753675E8 2.27E7 0.39 0.2747 0.7055 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 H24 mock treatment 1.2657959E8 7100000.0 0.09 1.49870145E8 9860000.0 0.17 0.1824 0.9553 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I01 compound treatment 1.02159352E8 -1.73E7 -0.22 1.23274807E8 -1.67E7 -0.29 -0.3562 -0.9907 1566570 TimTec1_000529 O=C(N1CCc2c([nH]c3ccccc23)C1c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I02 compound treatment 1.05508821E8 -1.4E7 -0.18 1.25844014E8 -1.42E7 -0.24 -0.2954 -0.9873 1193846 TimTec1_000530 OC(=O)CCc1cn(CCC(=O)O)cn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I03 compound treatment 1.1427288E8 -5210000.0 -0.07 1.26621779E8 -1.34E7 -0.23 -0.2082 -0.874 1083948 TimTec1_000531 Clc1ccc(NC(=O)Cc2ccccc2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I04 compound treatment 1.10863491E8 -8620000.0 -0.11 1.36020777E8 -3980000.0 -0.07 -0.1247 -0.9753 1450798 TimTec1_000532 CCOc1ccccc1C(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I05 compound treatment 1.204975E8 1010000.0 0.01 1.45064511E8 5060000.0 0.09 0.0702 0.8024 3210638 TimTec1_000533 CCOC(=O)c1c(NC(=O)CN2C(=O)S/C(=C/c3ccc(F)cc3)/C2=O)sc4CCCCc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I06 compound treatment 1.03197756E8 -1.63E7 -0.2 1.02205733E8 -3.78E7 -0.65 -0.602 -0.8872 1441802 TimTec1_000534 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3N(C2c4ccccc4)C(=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I07 compound treatment 1.27910494E8 8430000.0 0.11 1.43941132E8 3940000.0 0.07 0.1224 0.9763 3210639 TimTec1_000535 COc1ccc(CC(=O)Sc2nc3ccccc3s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I08 compound treatment 1.39426372E8 1.99E7 0.25 1.49374847E8 9370000.0 0.16 0.2903 0.9769 1043205 TimTec1_000536 COc1ccc2Sc3ccccc3Nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I09 compound treatment 1.10716745E8 -8770000.0 -0.11 1.27586151E8 -1.24E7 -0.21 -0.2281 -0.9529 1647938 TimTec1_000537 O=C(c1ccccc1)c2ccccc2OCc3nc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I10 compound treatment 9.7949999E7 -2.15E7 -0.27 1.20386885E8 -1.96E7 -0.34 -0.4285 -0.9942 1583677 TimTec1_000538 COC(=O)c1c(N)sc2CC(CCc12)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I11 compound treatment 1.1902986E8 -454000.0 -0.01 1.54477361E8 1.45E7 0.25 0.1712 0.6907 3210640 TimTec1_000539 OC(=O)c1ccccc1OCC(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I12 compound treatment 1.17260484E8 -2220000.0 -0.03 1.41644402E8 1640000.0 0.03 1.0E-4 0.0031 3081983 TimTec1_000540 Fc1ccc(CC(=O)Oc2ccccc2F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I13 compound treatment 1.19516787E8 33400.0 0.0 1.59939147E8 1.99E7 0.34 0.2416 0.708 1530773 TimTec1_000541 Clc1c(sc2ccccc12)C(=O)NC3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I14 compound treatment 1.30535388E8 1.11E7 0.14 1.58860926E8 1.89E7 0.32 0.3263 0.9288 1155672 TimTec1_000542 O=C(N(C1CCCC1)C2CCCC2)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I15 compound treatment 8.9973985E7 -2.95E7 -0.37 1.32939635E8 -7070000.0 -0.12 -0.3473 -0.8917 1319420 TimTec1_000543 Cc1cc2OCCn2c(=O)c1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I16 compound treatment 1.28958564E8 9480000.0 0.12 1.55653659E8 1.56E7 0.27 0.2735 0.9331 3210641 TimTec1_000544 CC(C)c1ccc(C)cc1OCCNC(=O)Nc2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I17 compound treatment 1.00659646E8 -1.88E7 -0.24 1.31751462E8 -8250000.0 -0.14 -0.2669 -0.9698 3081987 TimTec1_000545 Cc1cccc(c1)N2CCC(=N2)/N=C/N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I18 compound treatment 1.12240398E8 -7240000.0 -0.09 1.41520385E8 1520000.0 0.03 -0.0459 -0.4859 1266605 TimTec1_000546 O=C(NCc1ccc2OCOc2c1)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I19 compound treatment 1.09063311E8 -1.04E7 -0.13 1.35601795E8 -4400000.0 -0.08 -0.1457 -0.9658 1545215 TimTec1_000547 O=C(CCN1C(=O)CCC1=O)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I20 compound treatment 1.3199497E8 1.25E7 0.16 1.63719749E8 2.37E7 0.41 0.398 0.9145 3210642 TimTec1_000548 CC(Sc1nnnn1c2ccccc2)C(=O)Nc3c(C)cc(C)cc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I21 compound treatment 1.20569687E8 1090000.0 0.01 1.52319392E8 1.23E7 0.21 0.1587 0.7513 1121440 TimTec1_000549 OCCN1CC2CC(C1)c3cccc(=O)n3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I22 compound treatment 1.20498467E8 1020000.0 0.01 1.33668872E8 -6340000.0 -0.11 -0.0677 -0.6198 1565244 TimTec1_000550 O=C(CSC(c1ccccc1)c2ccccc2)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I23 mock treatment 1.25590436E8 6110000.0 0.08 1.66069498E8 2.61E7 0.45 0.3697 0.8166 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 I24 mock treatment 1.26861257E8 7380000.0 0.09 1.49821229E8 9820000.0 0.17 0.1843 0.9605 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J01 compound treatment 1.31499951E8 1.2E7 0.15 1.51274073E8 1.13E7 0.19 0.243 0.9926 3081991 TimTec1_000551 C(Sc1nc2ccccc2o1)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J02 compound treatment 1.04563306E8 -1.49E7 -0.19 1.1473879E8 -2.53E7 -0.43 -0.4382 -0.9298 1373763 TimTec1_000552 CCOc1cc(ccc1OC)C(=S)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J03 compound treatment 1.14926526E8 -4560000.0 -0.06 1.51371166E8 1.14E7 0.19 0.0972 0.4791 1655707 TimTec1_000553 CCOC(=O)c1cccc(c1)c2ccc(o2)C3C4C(OC(=C3C#N)N)c5ccccc5OC4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J04 compound treatment 1.29936221E8 1.05E7 0.13 1.51681944E8 1.17E7 0.2 0.2341 0.9791 3210643 TimTec1_000554 Cc1nc2ccccc2c(=O)n1/N=C/c3ccsc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J05 compound treatment 1.17448765E8 -2030000.0 -0.03 1.6831992E8 2.83E7 0.48 0.3247 0.6689 1122674 TimTec1_000555 CCOC(=O)C1=C(NC(=S)NC1C)C2CCC=CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J06 compound treatment 1.24584521E8 5100000.0 0.06 1.60952095E8 2.09E7 0.36 0.2988 0.8203 1230190 TimTec1_000556 CC(=O)Oc1ccc2nc(CN3C(=O)c4ccccc4C3=O)oc(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J07 compound treatment 1.10433701E8 -9050000.0 -0.11 1.39975622E8 -29700.0 0.0 -0.0806 -0.7103 1236736 TimTec1_000557 O=C(Oc1ccccc1)[C@@H]2[C@@H](c3ccoc3)C(C#N)(C#N)[C@H]4C=Cc5ccccc5N24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J08 compound treatment 1.291038E8 9620000.0 0.12 1.54589524E8 1.46E7 0.25 0.2619 0.9444 1297872 TimTec1_000558 CC(C)OC(=O)Oc1ccc2oc(=O)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J09 compound treatment 1.03364619E8 -1.61E7 -0.2 1.34311619E8 -5690000.0 -0.1 -0.2119 -0.944 1481447 TimTec1_000559 CC(O)(C#Cc1ccccc1)c2ccc(N3CCCCC3)c(F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J10 compound treatment 1.13177682E8 -6310000.0 -0.08 1.54426304E8 1.44E7 0.25 0.1186 0.4576 1391128 TimTec1_000560 CC1(C)CC(=O)c2cc(c3ccccc3)n(c2C1)c4ccc(cc4)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J11 compound treatment 1.29482541E8 1.0E7 0.13 1.69047079E8 2.9E7 0.5 0.4402 0.8586 3210645 TimTec1_000561 FC(F)(F)c1cccc(NCn2nc(oc2=S)c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J12 compound treatment 1.31598809E8 1.21E7 0.15 1.59137185E8 1.91E7 0.33 0.339 0.9391 1726909 TimTec1_000562 Clc1ccc(cc1)C(=O)NCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J13 compound treatment 1.39651633E8 2.02E7 0.25 1.6950346E8 2.95E7 0.5 0.536 0.9489 1416599 TimTec1_000563 NC1=C(C#N)C2=CCNCC2C(c3ccccc3)C1(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J14 compound treatment 1.06861459E8 -1.26E7 -0.16 1.44554213E8 4550000.0 0.08 -0.0569 -0.3225 3210646 TimTec1_000564 CCCc1cc2c(=O)c(c3ccc4OCCOc4c3)c(oc2c(C=N(C)C)c1O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J15 compound treatment 1.12381507E8 -7100000.0 -0.09 1.48624789E8 8620000.0 0.15 0.0413 0.2398 1693767 TimTec1_000565 CNC(=S)N(Cc1ccc(OC)cc1OC)c2ccc(I)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J16 compound treatment 1.24049837E8 4570000.0 0.06 1.49197808E8 9190000.0 0.16 0.1518 0.9063 1775537 TimTec1_000566 Cc1ccccc1C(=O)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J17 compound treatment 1.17976596E8 -1510000.0 -0.02 1.69306312E8 2.93E7 0.5 0.3413 0.68 3082061 TimTec1_000567 Cc1ccc(cc1)C(=O)CC(NCCc2c[nH]c3ccccc23)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J18 compound treatment 1.12190239E8 -7290000.0 -0.09 1.43107133E8 3100000.0 0.05 -0.0271 -0.2566 1438042 TimTec1_000568 CCN(C(=O)c1ccc(OC(=O)C)cc1)c2ccccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J19 compound treatment 1.19461101E8 -22300.0 0.0 1.21752813E8 -1.83E7 -0.31 -0.2211 -0.7077 1030998 TimTec1_000569 CCc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J20 compound treatment 1.25511201E8 6030000.0 0.08 1.45519899E8 5510000.0 0.09 0.1202 0.994 2085724 TimTec1_000570 CCc1cccc(C)c1NC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J21 compound treatment 1.15083959E8 -4400000.0 -0.06 1.15953806E8 -2.41E7 -0.41 -0.3301 -0.7948 1132592 TimTec1_000571 Clc1ccc(Cl)c(c1)S(=O)(=O)n2ccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J22 compound treatment 1.21835022E8 2350000.0 0.03 1.48372831E8 8370000.0 0.14 0.1221 0.8352 1473958 TimTec1_000572 CC(=O)Oc1ccccc1C(=O)NCc2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J23 mock treatment 1.08887927E8 -1.06E7 -0.13 1.40262517E8 257000.0 0.0 -0.0909 -0.6833 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 J24 mock treatment 1.21279841E8 1800000.0 0.02 1.4303152E8 3030000.0 0.05 0.0526 0.9305 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K01 compound treatment 8.3203414E7 -3.63E7 -0.46 1.06377878E8 -3.36E7 -0.58 -0.7288 -0.9932 1711757 TimTec1_000573 Clc1c(sc2ccccc12)C(=O)N3CCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K02 compound treatment 1.02563482E8 -1.69E7 -0.21 1.09627966E8 -3.04E7 -0.52 -0.5178 -0.9219 3082065 TimTec1_000574 C(=N/c1nc2ccccc2[nH]1)\N(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K03 compound treatment 9.1479281E7 -2.8E7 -0.35 9.94063E7 -4.06E7 -0.69 -0.7398 -0.9501 1572077 TimTec1_000575 O=C(NCCN1CCOCC1)c2ccc(cc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K04 compound treatment 1.03526839E8 -1.6E7 -0.2 1.14010646E8 -2.6E7 -0.44 -0.4562 -0.935 1453184 TimTec1_000576 CCC(C(=O)Nc1c(C)n(C)n(c2ccccc2)c1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K05 compound treatment 1.11372681E8 -8110000.0 -0.1 7.291856E7 -6.71E7 -1.15 -0.884 -0.7668 1610602 TimTec1_000577 Cc1cccc2nc(Cn3ccccc3=O)cn12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K06 compound treatment 1.10720046E8 -8760000.0 -0.11 1.11599058E8 -2.84E7 -0.49 -0.4216 -0.8456 3082068 TimTec1_000578 Clc1ccc(cc1Cl)C(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K07 compound treatment 1.21621774E8 2140000.0 0.03 7.5920152E7 -6.41E7 -1.1 -0.7567 -0.6896 1335233 TimTec1_000579 COc1ccc(CC(=O)Sc2nc3ccccc3o2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K08 compound treatment 1.04083426E8 -1.54E7 -0.19 1.1167908E8 -2.83E7 -0.48 -0.4795 -0.9186 1575168 TimTec1_000580 COC(=O)c1ccc(CSc2nc3ccccc3s2)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K09 compound treatment 1.1622534E8 -3260000.0 -0.04 1.35757918E8 -4250000.0 -0.07 -0.0803 -0.9629 1544044 TimTec1_000581 Cc1c([nH]c2ccccc12)c3ccccc3OC(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K10 compound treatment 1.19348564E8 -135000.0 0.0 1.2948787E8 -1.05E7 -0.18 -0.1285 -0.7137 1742152 TimTec1_000582 CC(C)(C)C1CCc2c(C#N)c(N)sc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K11 compound treatment 1.12920778E8 -6560000.0 -0.08 1.38047371E8 -1960000.0 -0.03 -0.0819 -0.9215 1582197 TimTec1_000583 CC(C)COc1ccc(OCC(C)C)c(N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K12 compound treatment 8.6706468E7 -3.28E7 -0.41 1.46169154E8 6160000.0 0.11 -0.2161 -0.5092 3210777 TimTec1_000584 Cc1cccc(OC(=O)Cc2ccc(F)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K13 compound treatment 1.04001758E8 -1.55E7 -0.19 1.24519501E8 -1.55E7 -0.27 -0.3248 -0.9883 1222918 TimTec1_000585 O=C(NC1CCC(CC2CCC(CC2)NC(=O)c3cccnc3)CC1)c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K14 compound treatment 1.32431365E8 1.29E7 0.16 1.48707758E8 8700000.0 0.15 0.2202 0.9991 1594065 TimTec1_000586 O=C(NCc1ccco1)C(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K15 compound treatment 1.48341491E8 2.89E7 0.36 1.76605525E8 3.66E7 0.63 0.699 0.966 1561515 TimTec1_000587 CCOC(=O)c1cnc(nc1NCc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K16 compound treatment 8.7470528E7 -3.2E7 -0.4 1.68405177E8 2.84E7 0.49 0.0598 0.0948 1376512 TimTec1_000588 O=C(CSCc1ccccc1)NCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K17 compound treatment 1.127947E8 -6690000.0 -0.08 9.7008848E7 -4.3E7 -0.74 -0.5798 -0.7826 3081162 TimTec1_000589 OCCN(CCO)/C=N/C1=NN(CC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K18 compound treatment 1.14212895E8 -5270000.0 -0.07 1.37882587E8 -2120000.0 -0.04 -0.0724 -0.9603 1454649 TimTec1_000590 Clc1ccc(CCNC(=O)C2(CC3CC4CC(C3)C2)C4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K19 compound treatment 1.29049726E8 9570000.0 0.12 1.40643236E8 638000.0 0.01 0.0926 0.7683 1521681 TimTec1_000591 O=C(CNC(=O)c1ccccc1)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K20 compound treatment 1.42649637E8 2.32E7 0.29 1.68238545E8 2.82E7 0.48 0.5472 0.9704 1335587 TimTec1_000592 O=C(CSc1cccc2cccnc12)NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K21 compound treatment 1.08194927E8 -1.13E7 -0.14 1.19571878E8 -2.04E7 -0.35 -0.3475 -0.9208 1610318 TimTec1_000593 CC(O)CN1CCCCC1c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K22 compound treatment 1.13886734E8 -5600000.0 -0.07 1.21416561E8 -1.86E7 -0.32 -0.2746 -0.8429 1566510 TimTec1_000594 O=C(CSCC(=O)Nc1ccccc1Oc2ccccc2)Nc3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K23 mock treatment 1.19649721E8 166000.0 0.0 1.36335908E8 -3670000.0 -0.06 -0.0429 -0.6832 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 K24 mock treatment 1.14835886E8 -4650000.0 -0.06 1.43132089E8 3130000.0 0.05 -0.0034 -0.0427 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L01 compound treatment 1.17530608E8 -1950000.0 -0.02 9.8190899E7 -4.18E7 -0.72 -0.5235 -0.7309 1594804 TimTec1_000595 O=C(CSc1nc(c[nH]1)c2ccccc2)c3ccc(cc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L02 compound treatment 1.11181522E8 -8300000.0 -0.1 1.1997436E8 -2.0E7 -0.34 -0.3161 -0.8821 1439459 TimTec1_000596 CC(=C1C2C=CC1C3C2C(=O)N(Cc4cccnc4)C3=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L03 compound treatment 8.4184193E7 -3.53E7 -0.44 1.30871395E8 -9130000.0 -0.16 -0.4237 -0.9022 3081167 TimTec1_000597 Cc1[nH]nc(O)c1C(C(C#N)C#N)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L04 compound treatment 1.09615013E8 -9870000.0 -0.12 1.33216526E8 -6790000.0 -0.12 -0.1697 -0.9995 1273129 TimTec1_000598 CCc1[nH]c(=S)c(C#N)c(c2ccccc2)c1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L05 compound treatment 1.09488024E8 -1.0E7 -0.13 1.19906541E8 -2.01E7 -0.34 -0.3319 -0.9065 3081169 TimTec1_000599 CN1C(=O)/C(=C/2\SC(=S)N(CC3CCCO3)C2=O)/c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L06 compound treatment 1.07859E8 -1.16E7 -0.15 1.1357058E8 -2.64E7 -0.45 -0.4231 -0.8899 1050772 TimTec1_000600 COc1cccc(c1)c2nnc(o2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L07 compound treatment 1.07036445E8 -1.24E7 -0.16 7.6531745E7 -6.35E7 -1.09 -0.8787 -0.8005 3081170 TimTec1_000601 CN(C)c1ccc(cc1)c2oncc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L08 compound treatment 1.14818558E8 -4660000.0 -0.06 1.08602221E8 -3.14E7 -0.54 -0.4215 -0.7795 1311113 TimTec1_000602 O=C(N1CCCCC1)c2cccc(c2)N3C(=O)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L09 compound treatment 1.16844011E8 -2640000.0 -0.03 1.09701437E8 -3.03E7 -0.52 -0.3902 -0.7507 1490753 TimTec1_000603 CC(O)(C#CC1(CC2CC3CC(C2)C1)C3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L10 compound treatment 7.7228334E7 -4.23E7 -0.53 6.3463261E7 -7.65E7 -1.31 -1.3013 -0.9207 1577974 TimTec1_000604 O=C(NC1CCCCC1)C2CCCN2C(=O)Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L11 compound treatment 7.233063E7 -4.72E7 -0.59 8.2167433E7 -5.78E7 -0.99 -1.1183 -0.9697 1352134 TimTec1_000605 Cc1ccc(Nc2nc(cs2)c3ccc(cc3)S(=O)(=O)N4CCCC4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L12 compound treatment 7.6413399E7 -4.31E7 -0.54 1.33609147E8 -6400000.0 -0.11 -0.4595 -0.8335 1230716 TimTec1_000606 Fc1ccc(cc1F)C(=O)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L13 compound treatment 7.9519497E7 -4.0E7 -0.5 9.1669291E7 -4.83E7 -0.83 -0.9396 -0.9712 1741888 TimTec1_000607 Cn1c2OC(=C(C#N)C(c3ccccc3)c2c(=O)n(C)c1=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L14 compound treatment 1.30927855E8 1.14E7 0.14 1.19629233E8 -2.04E7 -0.35 -0.1451 -0.3847 1654001 TimTec1_000608 O=c1oc2ccccc2cc1c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L15 compound treatment 1.07382321E8 -1.21E7 -0.15 7.4040737E7 -6.6E7 -1.13 -0.9058 -0.795 3210778 TimTec1_000609 CC(C)(C)c1ccc(cc1)C(=O)CC(NCc2ccccc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L16 compound treatment 1.0991384E8 -9570000.0 -0.12 7.8506198E7 -6.15E7 -1.05 -0.8293 -0.7827 1345015 TimTec1_000610 CC(O)CN1CC2CC(C1)c3cccc(=O)n3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L17 compound treatment 1.22714581E8 3230000.0 0.04 8.0348954E7 -5.97E7 -1.02 -0.6934 -0.6785 3210779 TimTec1_000611 CS/C(=N\C#N)/Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L18 compound treatment 1.14224908E8 -5260000.0 -0.07 7.5628348E7 -6.44E7 -1.1 -0.8259 -0.7481 1173928 TimTec1_000612 CC(=O)Oc1ccc(cc1)C(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L19 compound treatment 1.19251698E8 -232000.0 0.0 7.6277978E7 -6.37E7 -1.09 -0.7734 -0.709 3382 TimTec1_000613 Cc1c(CCO)sc[n+]1Cc2cnc(C)nc2N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L20 compound treatment 1.15226667E8 -4260000.0 -0.05 1.30892989E8 -9110000.0 -0.16 -0.1481 -0.898 3210780 TimTec1_000614 COc1ccc(CNC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L21 compound treatment 1.14893567E8 -4590000.0 -0.06 1.38098882E8 -1910000.0 -0.03 -0.0638 -0.9638 1705753 TimTec1_000615 CC1(OCCO1)c2ccc3noc(c4ccccc4)c3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L22 compound treatment 1.14056751E8 -5430000.0 -0.07 1.22387103E8 -1.76E7 -0.3 -0.2614 -0.8454 1592926 TimTec1_000616 CC(C)(C)c1ccc(cc1)C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L23 mock treatment 1.10027295E8 -9460000.0 -0.12 1.31968113E8 -8040000.0 -0.14 -0.1812 -0.9973 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 L24 mock treatment 1.20788806E8 1310000.0 0.02 1.37299242E8 -2710000.0 -0.05 -0.0212 -0.431 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M01 compound treatment 1.03014988E8 -1.65E7 -0.21 1.21749133E8 -1.83E7 -0.31 -0.3671 -0.9798 1026530 TimTec1_000617 Cc1cccc(c1)C(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M02 compound treatment 1.16919802E8 -2560000.0 -0.03 1.28293656E8 -1.17E7 -0.2 -0.1645 -0.8102 3081201 TimTec1_000618 COCn1nc(oc1=S)c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M03 compound treatment 1.20281699E8 798000.0 0.01 1.25399345E8 -1.46E7 -0.25 -0.1697 -0.6782 1048496 TimTec1_000619 Cc1ccccc1NC(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M04 compound treatment 1.1589645E8 -3590000.0 -0.04 1.29400383E8 -1.06E7 -0.18 -0.1602 -0.8565 1139431 TimTec1_000620 CCC(Oc1ccccc1)C(=O)Nc2sc3CCCCc3c2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M05 compound treatment 1.22825897E8 3340000.0 0.04 1.39122967E8 -882000.0 -0.02 0.019 0.4256 3081204 TimTec1_000621 O=C(NCSc1nc2ccccc2s1)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M06 compound treatment 1.13232621E8 -6250000.0 -0.08 1.37414212E8 -2590000.0 -0.04 -0.0868 -0.9636 3081205 TimTec1_000622 COC(=O)c1c(I)cnn1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M07 compound treatment 1.17388373E8 -2100000.0 -0.03 1.3449115E8 -5510000.0 -0.09 -0.0853 -0.8709 3210781 TimTec1_000623 C(/N=C/c1cccnc1)c2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M08 compound treatment 1.11747462E8 -7740000.0 -0.1 1.32073375E8 -7930000.0 -0.14 -0.1646 -0.9864 1442529 TimTec1_000624 Cc1c(cccc1C(=O)c2ccccc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M09 compound treatment 1.09803167E8 -9680000.0 -0.12 1.01013408E8 -3.9E7 -0.67 -0.5578 -0.8223 1549357 TimTec1_000625 COc1c(O)cc2CCCC(=O)Cc2c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M10 compound treatment 9.7566236E7 -2.19E7 -0.27 1.19754893E8 -2.03E7 -0.35 -0.4395 -0.9934 1364990 TimTec1_000626 CC(C)OC(=O)c1c(N)sc2CC(C)CCc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M11 compound treatment 1.1174373E8 -7740000.0 -0.1 1.27756524E8 -1.22E7 -0.21 -0.2169 -0.9388 1248596 TimTec1_000627 O=C(Cc1ccccc1)Sc2nc3ccccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M12 compound treatment 1.1491635E8 -4570000.0 -0.06 1.4136665E8 1360000.0 0.02 -0.024 -0.3886 3210782 TimTec1_000628 NNC(=O)CCCNc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M13 compound treatment 1.10289086E8 -9190000.0 -0.12 1.29249273E8 -1.08E7 -0.18 -0.2117 -0.9746 1664419 TimTec1_000629 O=C(Nc1ccc(Cc2ccc(NC(=O)C3CC3)cc2)cc1)C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M14 compound treatment 1.12729517E8 -6750000.0 -0.08 1.31970947E8 -8030000.0 -0.14 -0.1572 -0.9729 3081210 TimTec1_000630 COc1cccc(OCCNC(=O)c2cccc3ccccc23)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M15 compound treatment 1.18403905E8 -1080000.0 -0.01 1.22486012E8 -1.75E7 -0.3 -0.2216 -0.7383 1630369 TimTec1_000631 C(Cc1ccco1)C2=NCCn3cccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M16 compound treatment 1.14949012E8 -4530000.0 -0.06 1.34037248E8 -5970000.0 -0.1 -0.1125 -0.9618 3210783 TimTec1_000632 CC1CC(CC(C)(C)C1)NC(=O)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M17 compound treatment 1.09966848E8 -9520000.0 -0.12 1.30374753E8 -9630000.0 -0.16 -0.201 -0.9874 2106961 TimTec1_000633 O=S(=O)(Nc1nc2ccccc2nc1[n+]3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M18 compound treatment 1.2346387E8 3980000.0 0.05 1.41891961E8 1890000.0 0.03 0.0581 0.9778 1408031 TimTec1_000634 O=C(NCc1ccc2OCOc2c1)c3cc4ccccc4o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M19 compound treatment 1.18593769E8 -890000.0 -0.01 1.42156106E8 2150000.0 0.04 0.0181 0.4716 1186272 TimTec1_000635 O=C(OCC1CCCN2CCCCC12)C3CCNCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M20 compound treatment 1.19985374E8 502000.0 0.01 1.39378509E8 -627000.0 -0.01 -0.0031 -0.2519 3210784 TimTec1_000636 S(C(c1ccccc1)c2ccccc2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M21 compound treatment 1.16001352E8 -3480000.0 -0.04 1.37013251E8 -2990000.0 -0.05 -0.0671 -0.9969 1230906 TimTec1_000637 Brc1cccc(c1)C(=O)NCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M22 compound treatment 1.0326919E8 -1.62E7 -0.2 1.26298108E8 -1.37E7 -0.23 -0.3097 -0.9975 3081216 TimTec1_000638 COc1ccc(cc1)c2nnc(SCc3ccc(F)cc3)n2c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M23 mock treatment 1.07867867E8 -1.16E7 -0.15 1.34827281E8 -5180000.0 -0.09 -0.1657 -0.9716 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 M24 mock treatment 1.23868375E8 4380000.0 0.06 1.35969241E8 -4040000.0 -0.07 -0.01 -0.1127 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N01 compound treatment 1.28990514E8 9510000.0 0.12 8.792442E7 -5.21E7 -0.89 -0.5461 -0.6071 3210785 TimTec1_000639 O=C(CSc1ccccn1)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N02 compound treatment 1.2624024E8 6760000.0 0.08 1.32286386E8 -7720000.0 -0.13 -0.0335 -0.2134 3081217 TimTec1_000640 CC1CC(C)CN(C1)S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N03 compound treatment 1.33788047E8 1.43E7 0.18 1.41773092E8 1770000.0 0.03 0.1483 0.8148 3210786 TimTec1_000641 Cc1ccc2nc(oc2c1)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N04 compound treatment 1.20575027E8 1090000.0 0.01 1.48732196E8 8730000.0 0.15 0.1153 0.7687 1304545 TimTec1_000642 CC1(O)N(CCc2ccccc2)C(=O)OC31CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N05 compound treatment 1.29593674E8 1.01E7 0.13 1.3801331E8 -1990000.0 -0.03 0.0656 0.4993 3081220 TimTec1_000643 CN1C(=O)/C(=c/2\sc3nc(nn3c2=O)c4ccccc4)/c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N06 compound treatment 1.45123795E8 2.56E7 0.32 1.31625084E8 -8380000.0 -0.14 0.126 0.3578 1284486 TimTec1_000644 CC1CCN(Cc2cc(Cl)c3cccnc3c2O)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N07 compound treatment 1.3605947E8 1.66E7 0.21 1.55235079E8 1.52E7 0.26 0.3314 0.9937 1505391 TimTec1_000645 CC(Oc1ccccc1OC(=O)C)c2nn(C(=O)C)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N08 compound treatment 1.21847449E8 2360000.0 0.03 1.22258953E8 -1.77E7 -0.3 -0.1938 -0.6351 3210905 TimTec1_000646 OCCCn/1c(cs\c1=N/c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N09 compound treatment 1.41071782E8 2.16E7 0.27 1.30196989E8 -9810000.0 -0.17 0.0728 0.2284 3210906 TimTec1_000647 CSc1nc(N)nc(SCC(=O)Nc2ccccc2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N10 compound treatment 1.22242875E8 2760000.0 0.03 1.42544462E8 2540000.0 0.04 0.0552 0.9936 1155124 TimTec1_000648 CC(C)CC(C(=O)N)C1=NC(C)(C)Cc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N11 compound treatment 1.18824915E8 -658000.0 -0.01 1.29309258E8 -1.07E7 -0.18 -0.1353 -0.7383 1713559 TimTec1_000649 CSc1nc2ccc(NC(=O)CCc3ccccc3)cc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N12 compound treatment 1.14880749E8 -4600000.0 -0.06 1.39519231E8 -486000.0 -0.01 -0.0467 -0.8007 3081224 TimTec1_000650 CC(=C)C1CCC2(C)OC(=O)N(Cc3ccccc3)C12C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N13 compound treatment 1.16095567E8 -3390000.0 -0.04 1.42937226E8 2930000.0 0.05 0.0054 0.0827 1489806 TimTec1_000651 Clc1ccc(cc1)C2=CC(c3ccccc3)n4ncnc4N2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N14 compound treatment 9.1201922E7 -2.83E7 -0.35 9.429148E7 -4.57E7 -0.78 -0.8042 -0.936 1607919 TimTec1_000652 CC(C)C(=O)OCC1CCCN2CCCCC12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N15 compound treatment 1.26755716E8 7270000.0 0.09 1.40211503E8 206000.0 0.0 0.067 0.7339 3081227 TimTec1_000653 Oc1ccccc1/C=N/c2ncc(cc2Cl)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N16 compound treatment 1.28898697E8 9420000.0 0.12 1.5349551E8 1.35E7 0.23 0.2468 0.9515 1250530 TimTec1_000654 Cc1ccc(C)c(NC(=O)CC(Cc2ccccc2)C(=O)O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N17 compound treatment 1.29894919E8 1.04E7 0.13 1.44638697E8 4630000.0 0.08 0.1484 0.9714 3081228 TimTec1_000655 CS/C(=N\C#N)/Nc1ccc(C)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N18 compound treatment 1.28472867E8 8990000.0 0.11 1.08437356E8 -3.16E7 -0.54 -0.3024 -0.5477 3210907 TimTec1_000656 CCN(CC)C(=O)c1ccc(OC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N19 compound treatment 1.18390617E8 -1090000.0 -0.01 1.47945755E8 7940000.0 0.14 0.0864 0.6326 2709 TimTec1_000657 Cc1ncc(CO)c(CO)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N20 compound treatment 1.26478703E8 7000000.0 0.09 1.46817554E8 6810000.0 0.12 0.1445 0.9902 3081230 TimTec1_000658 CCN(Cc1ccccc1)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N21 compound treatment 1.26962952E8 7480000.0 0.09 1.43435606E8 3430000.0 0.06 0.1079 0.9745 3210908 TimTec1_000659 FC(F)(F)c1nc2ccccc2nc1c3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N22 compound treatment 1.16497585E8 -2990000.0 -0.04 1.43353251E8 3350000.0 0.06 0.014 0.2051 1661635 TimTec1_000660 CC(C)(C)c1ccc(cc1)C(=O)NCCN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N23 mock treatment 1.19347974E8 -135000.0 0.0 1.40759517E8 754000.0 0.01 0.0079 0.6088 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 N24 mock treatment 1.18059022E8 -1420000.0 -0.02 1.41615684E8 1610000.0 0.03 0.0069 0.2088 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O01 compound treatment 8.4288826E7 -3.52E7 -0.44 1.18682757E8 -2.13E7 -0.36 -0.5703 -0.9955 1674716 TimTec1_000661 COc1ccc(CC(=O)N2CCN(CC2)c3ccccc3OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O02 compound treatment 1.02973774E8 -1.65E7 -0.21 1.16043492E8 -2.4E7 -0.41 -0.4365 -0.9499 1336284 TimTec1_000662 COc1c2CC(Oc2nc3ccccc13)C(C)(O)CO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O03 compound treatment 1.05253196E8 -1.42E7 -0.18 1.27512864E8 -1.25E7 -0.21 -0.2774 -0.996 1432196 TimTec1_000663 O=C(Cc1ccccc1)NCCN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O04 compound treatment 1.03807062E8 -1.57E7 -0.2 1.21827885E8 -1.82E7 -0.31 -0.3591 -0.9755 1552779 TimTec1_000664 CCC(C(=O)Nc1cccc(NC(=O)C)c1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O05 compound treatment 1.06641703E8 -1.28E7 -0.16 1.25858919E8 -1.41E7 -0.24 -0.2851 -0.9804 3210909 TimTec1_000665 CC(C)(C)/N=C/1\OC(NC(=S)N1c2ccccc2)(c3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O06 compound treatment 1.10227415E8 -9260000.0 -0.12 1.22921982E8 -1.71E7 -0.29 -0.2889 -0.9181 3081248 TimTec1_000666 Cn1ncc(Br)c1C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O07 compound treatment 9.5271083E7 -2.42E7 -0.3 1.12908154E8 -2.71E7 -0.46 -0.5428 -0.9789 1391171 TimTec1_000667 O=C(Cc1ccccc1)SC2=NCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O08 compound treatment 1.08793029E8 -1.07E7 -0.13 1.26581847E8 -1.34E7 -0.23 -0.2573 -0.9671 1548144 TimTec1_000668 Nc1ccccc1N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O09 compound treatment 1.02353522E8 -1.71E7 -0.21 1.14271474E8 -2.57E7 -0.44 -0.4634 -0.9455 1262651 TimTec1_000669 OC(=O)c1ccccc1OCc2ccc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O10 compound treatment 7.9751399E7 -3.97E7 -0.5 1.01018091E8 -3.9E7 -0.67 -0.8243 -0.9897 1660487 TimTec1_000670 Cc1cc(Nc2ccccc2)nc(Nc3ccccc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O11 compound treatment 9.3429326E7 -2.61E7 -0.33 1.175894E8 -2.24E7 -0.38 -0.5024 -0.9968 3210910 TimTec1_000671 N#Cc1cnoc1N2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O12 compound treatment 1.00450172E8 -1.9E7 -0.24 1.24837472E8 -1.52E7 -0.26 -0.3524 -0.9991 1484966 TimTec1_000672 CN1CCN(CC(O)COc2ccc3ccccc3c2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O13 compound treatment 9.1655866E7 -2.78E7 -0.35 1.24061583E8 -1.59E7 -0.27 -0.4398 -0.9926 1229967 TimTec1_000673 COc1ccc2nc(C)cc(N3CCOCC3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O14 compound treatment 1.04625464E8 -1.49E7 -0.19 1.27719545E8 -1.23E7 -0.21 -0.2805 -0.9982 3210911 TimTec1_000674 Cc1ccc(OCCNC(=O)c2ccc(cc2)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O15 compound treatment 9.5458157E7 -2.4E7 -0.3 1.2913836E8 -1.09E7 -0.19 -0.3446 -0.9731 1008172 TimTec1_000675 O=C(N(C1CCCCC1)C2CCCCC2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O16 compound treatment 1.10932748E8 -8550000.0 -0.11 1.25519355E8 -1.45E7 -0.25 -0.2512 -0.9297 1563007 TimTec1_000676 CS(=O)(=O)NCc1cccc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O17 compound treatment 1.04672179E8 -1.48E7 -0.19 1.31108378E8 -8900000.0 -0.15 -0.2391 -0.9951 3210912 TimTec1_000677 CC1=NN(C(=O)C1/C=C/2\SC(=S)N(CC3CCCO3)C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O18 compound treatment 1.17387126E8 -2100000.0 -0.03 1.42131235E8 2130000.0 0.04 0.0071 0.159 1336524 TimTec1_000678 O=C(NCc1ccccn1)C(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O19 compound treatment 8.4333373E7 -3.52E7 -0.44 1.31819297E8 -8190000.0 -0.14 -0.4109 -0.8881 1536621 TimTec1_000679 CC(=O)NCC1CCCN2CCCCC12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O20 compound treatment 1.10334241E8 -9150000.0 -0.11 1.34576444E8 -5430000.0 -0.09 -0.1469 -0.9945 1425414 TimTec1_000680 CCOc1ccc2nc(SCC(=O)N3CCOCC3)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O21 compound treatment 1.08302113E8 -1.12E7 -0.14 1.29342351E8 -1.07E7 -0.18 -0.2282 -0.9915 3210913 TimTec1_000681 C[N+]1(CCOCC2CCC[N+]3(C)CCCCC23)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O22 compound treatment 1.09870233E8 -9610000.0 -0.12 1.32971115E8 -7030000.0 -0.12 -0.1704 -1.0 3081257 TimTec1_000682 Nc1nnc(SCC(=O)c2ccccc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O23 mock treatment 1.06682345E8 -1.28E7 -0.16 1.32351584E8 -7650000.0 -0.13 -0.2062 -0.9949 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 O24 mock treatment 1.13654297E8 -5830000.0 -0.07 1.36848641E8 -3160000.0 -0.05 -0.0899 -0.9889 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P01 compound treatment 1.11171424E8 -8310000.0 -0.1 1.26533392E8 -1.35E7 -0.23 -0.2368 -0.9356 3210914 TimTec1_000683 Cn1nnnc1SC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P02 compound treatment 1.0551898E8 -1.4E7 -0.18 1.28510193E8 -1.15E7 -0.2 -0.263 -0.9983 1610147 TimTec1_000684 O=C(NC(c1ccccc1)c2ccccc2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P03 compound treatment 1.13661261E8 -5820000.0 -0.07 1.27652988E8 -1.24E7 -0.21 -0.2012 -0.8992 3210915 TimTec1_000685 COC(=O)C1=C(C)N=C2SCCC(=O)N2C1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P04 compound treatment 1.11998318E8 -7490000.0 -0.09 1.29398726E8 -1.06E7 -0.18 -0.1948 -0.9529 3210916 TimTec1_000686 CCCCS(=O)(=O)/C=C/C1C(C2CC1C=C2)S(=O)(=O)CCCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P05 compound treatment 1.12032605E8 -7450000.0 -0.09 1.29557502E8 -1.04E7 -0.18 -0.1926 -0.9542 3081261 TimTec1_000687 Cc1c(NC(=O)/C(=C/c2ccccc2)/NC(=O)c3ccc(C)cc3)c(=O)n(c4ccccc4)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P06 compound treatment 1.08976465E8 -1.05E7 -0.13 1.29256496E8 -1.07E7 -0.18 -0.2233 -0.9866 3210917 TimTec1_000688 CCOC(=O)CN(C1=NS(=O)(=O)c2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P07 compound treatment 1.05902242E8 -1.36E7 -0.17 1.24924274E8 -1.51E7 -0.26 -0.303 -0.9797 1583564 TimTec1_000689 OC(=O)c1ccccc1OCC(=O)NCCN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P08 compound treatment 1.06840736E8 -1.26E7 -0.16 1.16369818E8 -2.36E7 -0.4 -0.3982 -0.9164 1715711 TimTec1_000690 CC(C)N(C(C)C)C(=O)c1ccc(cc1)c2nnc(o2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P09 compound treatment 1.09446487E8 -1.0E7 -0.13 1.20907948E8 -1.91E7 -0.33 -0.3202 -0.914 1353777 TimTec1_000691 Cc1cc2OC(=C(C#N)C(c3ccc(F)cc3)c2c(=O)o1)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P10 compound treatment 1.10213834E8 -9270000.0 -0.12 1.35825339E8 -4180000.0 -0.07 -0.1328 -0.9728 1375739 TimTec1_000692 CN(C)c1ccc(cc1)n2c(=O)c3cc4c(=O)n(c5ccc(cc5)N(C)C)c(=O)c4cc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P11 compound treatment 1.07889407E8 -1.16E7 -0.15 1.25686046E8 -1.43E7 -0.25 -0.2762 -0.9689 1562644 TimTec1_000693 COc1ccc(CNCC2(CCCC2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P12 compound treatment 1.06905916E8 -1.26E7 -0.16 1.25289085E8 -1.47E7 -0.25 -0.2897 -0.9746 1540542 TimTec1_000694 Cc1ccc(CCP(=O)(O)CCc2ccc(C)nc2)cn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P13 compound treatment 9.9683548E7 -1.98E7 -0.25 1.20448937E8 -1.96E7 -0.33 -0.4123 -0.9892 1525917 TimTec1_000695 OC(=O)C(CC(=O)c1ccc(Br)cc1)SC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P14 compound treatment 8.452952E7 -3.5E7 -0.44 8.0055831E7 -5.99E7 -1.03 -1.0357 -0.9281 1646318 TimTec1_000696 O=C(Cc1ccccc1)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P15 compound treatment 9.0605553E7 -2.89E7 -0.36 1.05454099E8 -3.46E7 -0.59 -0.6744 -0.9723 3210918 TimTec1_000697 OC(=O)C(CC(=O)c1ccc(Cl)cc1)NC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P16 compound treatment 1.11525892E8 -7960000.0 -0.1 1.32025674E8 -7980000.0 -0.14 -0.1672 -0.9881 3081269 TimTec1_000698 CCCn1c(=O)n(CCC)c2c(C)cc(C)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P17 compound treatment 1.06872633E8 -1.26E7 -0.16 1.30697373E8 -9310000.0 -0.16 -0.2245 -1.0 3210919 TimTec1_000699 OC(=O)C(CC(=O)c1ccc(cc1)C2CCCCC2)N3CCN(CC3)c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P18 compound treatment 1.06958417E8 -1.25E7 -0.16 1.35063259E8 -4940000.0 -0.08 -0.1709 -0.9578 3081271 TimTec1_000700 CNC(=O)c1ccc(OC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P19 compound treatment 1.16088545E8 -3390000.0 -0.04 1.26314871E8 -1.37E7 -0.23 -0.1958 -0.8221 3081273 TimTec1_000701 Cn1cc(I)c(n1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P20 compound treatment 1.12990435E8 -6490000.0 -0.08 1.24021973E8 -1.6E7 -0.27 -0.2511 -0.8795 3081274 TimTec1_000702 CCN(C(=O)C)c1ccccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P21 compound treatment 1.02252321E8 -1.72E7 -0.22 1.21354787E8 -1.87E7 -0.32 -0.3786 -0.982 1207599 TimTec1_000703 Cc1ccc(cc1C)N2C(=O)c3ccc(cc3C2=O)C(=O)N(CCO)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P22 compound treatment 1.19547681E8 64300.0 0.0 1.30570763E8 -9430000.0 -0.16 -0.1136 -0.7036 1637859 TimTec1_000704 Clc1ccc(Cl)c(c1)C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P23 mock treatment 1.0971675E8 -9770000.0 -0.12 1.40346964E8 342000.0 0.01 -0.0825 -0.6726 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2064 P24 mock treatment 1.16681842E8 -2800000.0 -0.04 1.22897801E8 -1.71E7 -0.29 -0.2319 -0.7863 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A01 compound treatment 1.27609157E8 -195000.0 0.0 1.50972645E8 1.06E7 0.18 0.1263 0.6975 3081276 TimTec1_000705 CN(C)C(=O)c1cc(Cl)ccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A02 compound treatment 1.31277181E8 3470000.0 0.04 1.49007266E8 8620000.0 0.15 0.1351 0.8785 1727664 TimTec1_000706 Cc1cccc(NC(=O)c2cnn(c2NC(=O)c3ccco3)c4ccccc4)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A03 compound treatment 1.32955959E8 5150000.0 0.06 1.46329535E8 5940000.0 0.1 0.1176 0.9761 1225534 TimTec1_000707 O=C(CC(c1ccccc1)c2ccccc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A04 compound treatment 1.28360974E8 556000.0 0.01 1.36018897E8 -4370000.0 -0.07 -0.048 -0.6384 3211034 TimTec1_000708 COC(=O)CSc1nc(ccc1C#N)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A05 compound treatment 1.39547316E8 1.17E7 0.15 9.3395412E7 -4.7E7 -0.8 -0.4647 -0.5682 1669652 TimTec1_000709 O=C(CSc1nc2ccccc2o1)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A06 compound treatment 1.34324196E8 6520000.0 0.08 1.69460057E8 2.91E7 0.5 0.4097 0.8124 1013954 TimTec1_000710 COC(=O)c1cccc(c1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A07 compound treatment 1.47000098E8 1.92E7 0.24 1.53205074E8 1.28E7 0.22 0.3254 0.9989 1089954 TimTec1_000711 OC(=O)c1ccc(Oc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A08 compound treatment 1.36673483E8 8870000.0 0.11 1.63031225E8 2.26E7 0.39 0.3527 0.8748 1005718 TimTec1_000712 OC(=O)CCC(=O)OCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A09 compound treatment 1.35728692E8 7920000.0 0.1 1.54927418E8 1.45E7 0.25 0.2462 0.919 1474924 TimTec1_000713 CN(C)Cc1ccc(cc1)C(=O)Oc2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A10 compound treatment 1.17121319E8 -1.07E7 -0.13 1.40022012E8 -370000.0 -0.01 -0.0992 -0.7397 3211035 TimTec1_000714 Oc1cccc(/N=C/c2cc(Br)ccc2O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A11 compound treatment 1.38145897E8 1.03E7 0.13 1.50980086E8 1.06E7 0.18 0.2199 0.9866 3081282 TimTec1_000715 Cc1ccc(O)c(c1)C2=Nc3ccccc3N=C(C2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A12 compound treatment 1.26893513E8 -911000.0 -0.01 1.57520439E8 1.71E7 0.29 0.1992 0.679 1433969 TimTec1_000716 Cc1cccc(c1)C(=O)NN(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A13 compound treatment 1.28967817E8 1160000.0 0.01 1.70007506E8 2.96E7 0.51 0.3688 0.7272 1483255 TimTec1_000717 CC(=O)Nc1cccc2ncccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A14 compound treatment 1.4152848E8 1.37E7 0.17 1.58393901E8 1.8E7 0.31 0.3396 0.9622 1158197 TimTec1_000718 COc1ccc(cc1)C(=O)Nc2ccc(C)c(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A15 compound treatment 1.4690122E8 1.91E7 0.24 1.60109619E8 1.97E7 0.34 0.4081 0.9859 3211036 TimTec1_000719 C/C(=N\n1cnnc1)/CC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A16 compound treatment 1.48569473E8 2.08E7 0.26 1.52765165E8 1.24E7 0.21 0.334 0.9947 1075886 TimTec1_000720 FC(F)(F)c1cccc(NS(=O)(=O)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A17 compound treatment 9.4905064E7 -3.29E7 -0.41 1.68318601E8 2.79E7 0.48 0.0462 0.0731 1922764 TimTec1_000721 OC(=O)c1cc(/N=C/c2ccccc2O)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A18 compound treatment 1.35731866E8 7930000.0 0.1 1.44605091E8 4210000.0 0.07 0.1213 0.9875 1340286 TimTec1_000722 COc1ccc(cc1)S(=O)(=O)Nc2cc(C)cc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A19 compound treatment 1.21624232E8 -6180000.0 -0.08 1.37712821E8 -2680000.0 -0.05 -0.0873 -0.9686 1715796 TimTec1_000723 CCOC(=O)c1c(CSc2nc(C)ccc2C#N)oc3ccc(OC(=O)C)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A20 compound treatment 1.54247854E8 2.64E7 0.33 1.25541089E8 -1.49E7 -0.25 0.0548 0.1311 3211037 TimTec1_000724 COC(=O)C1=C(N)C(=c2s/c(=C/c3ccccc3)/c(=O)n2C1c4ccccc4)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A21 compound treatment 1.29743762E8 1940000.0 0.02 1.34467855E8 -5920000.0 -0.1 -0.0545 -0.5227 3081301 TimTec1_000725 NC1=C(C#N)[C@@H]([C@H](S1)C(=O)c2ccccc2)c3ccc(Br)c(F)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A22 compound treatment 1.414722E8 1.37E7 0.17 1.74179782E8 3.38E7 0.58 0.5302 0.8789 1561863 TimTec1_000726 O=C(Nc1nc(nc2CCCC(=O)c12)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A23 mock treatment 1.68700012E8 4.09E7 0.51 1.10330258E8 -3.01E7 -0.51 -0.0011 -0.0015 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 A24 mock treatment 1.06048515E8 -2.18E7 -0.27 1.70768726E8 3.04E7 0.52 0.1747 0.2975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B01 compound treatment 8.5598283E7 -4.22E7 -0.53 1.17951961E8 -2.24E7 -0.38 -0.646 -0.9876 3081303 TimTec1_000727 Cc1cccc[n+]1C2[C@H](C(=C(S)N[C@]2(C)O)C#N)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B02 compound treatment 1.49334216E8 2.15E7 0.27 1.15328479E8 -2.51E7 -0.43 -0.1124 -0.2217 3211038 TimTec1_000728 CC1C(CC(C(=O)O)C1(C)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B03 compound treatment 9.813708E7 -2.97E7 -0.37 1.00519673E8 -3.99E7 -0.68 -0.7458 -0.9593 3211039 TimTec1_000729 CC1=COC=C(/C=N/Cc2ccccc2)N1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B04 compound treatment 7.5352918E7 -5.25E7 -0.66 7.0382979E7 -7.0E7 -1.2 -1.3127 -0.9601 3081306 TimTec1_000730 O=C(CSC#N)c1cccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B05 compound treatment 1.31919734E8 4120000.0 0.05 1.35032578E8 -5360000.0 -0.09 -0.0284 -0.2695 1225786 TimTec1_000731 COc1cccc2c1N(C3CC(C)CCC3C2(C)C)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B06 compound treatment 1.1463004E8 -1.32E7 -0.17 9.5685943E7 -4.47E7 -0.77 -0.658 -0.8404 1605606 TimTec1_000732 c1ccc(nc1)c2ccc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B07 compound treatment 9.5557822E7 -3.22E7 -0.4 9.6874608E7 -4.35E7 -0.74 -0.8128 -0.9588 1478193 TimTec1_000733 CCC(=O)Nc1ncc2C(=O)CC(C)(C)Cc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B08 compound treatment 1.10696417E8 -1.71E7 -0.21 1.46159347E8 5770000.0 0.1 -0.0819 -0.3469 3081309 TimTec1_000734 COc1ccc(cc1)/C(=N/O)/C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B09 compound treatment 1.3913353E8 1.13E7 0.14 1.06366566E8 -3.4E7 -0.58 -0.3114 -0.5193 3211040 TimTec1_000735 CCOC(=O)Cc1n[nH]c(CC(=O)OCC)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B10 compound treatment 2.91210227E8 1.63E8 2.05 1.9462829E8 5.42E7 0.93 2.1059 0.9359 3081311 TimTec1_000736 Nc1ccc2nn(nc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B11 compound treatment 1.70563014E8 4.28E7 0.54 8.1176265E7 -5.92E7 -1.01 -0.3375 -0.2943 1090166 TimTec1_000737 CN(C)c1c(C)n(C)n(c2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B12 compound treatment 1.09857583E8 -1.79E7 -0.23 1.54141247E8 1.37E7 0.24 0.0072 0.0222 3081313 TimTec1_000738 CCOc1ccc(cc1)C(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B13 compound treatment 1.43923842E8 1.61E7 0.2 9.8237396E7 -4.22E7 -0.72 -0.3673 -0.4901 3211041 TimTec1_000739 COc1cccc(/C=N/n2cnnc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B14 compound treatment 9.9930025E7 -2.79E7 -0.35 9.2018128E7 -4.84E7 -0.83 -0.8328 -0.9265 3211042 TimTec1_000740 C[N+]1(C/C=C\2/COCO2)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B15 compound treatment 1.59182954E8 3.14E7 0.39 1.06431538E8 -3.4E7 -0.58 -0.1327 -0.1891 1498488 TimTec1_000741 COc1ccc(CC(=O)NC2CCCCC2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B16 compound treatment 6.2553527E7 -6.53E7 -0.82 7.3839451E7 -6.66E7 -1.14 -1.3844 -0.9868 3211043 TimTec1_000742 OC(=O)c1cc(/C=N/n2cnnc2)c3OCOCc3c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B17 compound treatment 9.5065812E7 -3.27E7 -0.41 1.28428354E8 -1.2E7 -0.2 -0.4352 -0.9483 3211044 TimTec1_000743 Cc1nc(cs1)C2C(Oc3c(O)c(O)ccc3C2=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B18 compound treatment 1.19661705E8 -8140000.0 -0.1 7.6897807E7 -6.35E7 -1.09 -0.8408 -0.7702 3081317 TimTec1_000744 OC(CN1CC2CC(C1)c3cccc(=O)n3C2)/C=N/n4cnnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B19 compound treatment 8.513348E7 -4.27E7 -0.54 8.8663932E7 -5.17E7 -0.89 -1.0046 -0.9709 3081354 TimTec1_000745 C(/C=C\c1ccccc1)N2CCN(Cn3nnc4ccccc34)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B20 compound treatment 1.5062444E8 2.28E7 0.29 9.2809773E7 -4.76E7 -0.81 -0.3735 -0.4326 3081321 TimTec1_000746 CC(CN1CC2CC(C1)c3cccc(=O)n3C2)SC(=N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B21 compound treatment 1.24782884E8 -3020000.0 -0.04 1.0909753E8 -3.13E7 -0.54 -0.4056 -0.7553 1281576 TimTec1_000747 CN(C1CCCCC1)S(=O)(=O)c2ccc(NC(=O)C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B22 compound treatment 2.56483987E8 1.29E8 1.61 2.82463366E8 1.42E8 2.43 2.8611 0.9802 1293326 TimTec1_000748 CC1(C)CC(=O)C2=C(C1)Nc3ccc4ccccc4c3C2c5cccnc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B23 mock treatment 9.2778675E7 -3.5E7 -0.44 1.00244141E8 -4.01E7 -0.69 -0.7967 -0.9766 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 B24 mock treatment 9.9589963E7 -2.82E7 -0.35 9.8902756E7 -4.15E7 -0.71 -0.7525 -0.9483 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C01 compound treatment 1.26724355E8 -1080000.0 -0.01 1.37098758E8 -3290000.0 -0.06 -0.0494 -0.8528 3081323 TimTec1_000749 CC1CCN(CC1)C(=O)c2cc(Cl)ccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C02 compound treatment 1.32147767E8 4340000.0 0.05 1.48153582E8 7760000.0 0.13 0.1325 0.9225 1165155 TimTec1_000750 CCN(CC)C(=O)c1cnn(c1NC(=O)c2ccco2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C03 compound treatment 8.7827246E7 -4.0E7 -0.5 7.1639217E7 -6.88E7 -1.18 -1.1868 -0.9277 3081325 TimTec1_000751 CCN(CC)c1ccc(/C=N/O)c(O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C04 compound treatment 1.37688048E8 9880000.0 0.12 1.44512228E8 4120000.0 0.07 0.1375 0.9642 1058529 TimTec1_000752 OC(=O)c1ccccc1N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C05 compound treatment 1.39913811E8 1.21E7 0.15 1.44569247E8 4180000.0 0.07 0.158 0.9409 1643767 TimTec1_000753 CSc1nc2ccccc2n1CC(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C06 compound treatment 1.36257386E8 8450000.0 0.11 1.45544405E8 5150000.0 0.09 0.1373 0.9958 1016928 TimTec1_000754 CC(C)CNC(=O)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C07 compound treatment 1.37802784E8 1.0E7 0.13 1.6515381E8 2.48E7 0.42 0.3884 0.8787 3211045 TimTec1_000755 Cc1ccc(C)n1c2ccc(cc2)C(=O)OCC(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C08 compound treatment 1.39118926E8 1.13E7 0.14 1.56719187E8 1.63E7 0.28 0.298 0.9506 1586419 TimTec1_000756 CC1CC2OC(C)(C)OC2C(OC(=O)c3ccccc3)O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C09 compound treatment 1.31303273E8 3500000.0 0.04 1.3658037E8 -3810000.0 -0.07 -0.0151 -0.1921 1233022 TimTec1_000757 CC(C)CCOc1ccccc1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C10 compound treatment 1.33695699E8 5890000.0 0.07 1.40606601E8 214000.0 0.0 0.0549 0.7413 3081330 TimTec1_000758 Cc1ccc(/N=C/c2cc3ccccc3nc2Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C11 compound treatment 1.34133961E8 6330000.0 0.08 1.52481994E8 1.21E7 0.21 0.2025 0.9135 3211046 TimTec1_000759 FC(F)(F)c1cc(no1)c2ccc3ccccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C12 compound treatment 1.39167782E8 1.14E7 0.14 1.38130061E8 -2260000.0 -0.04 0.0734 0.497 3081332 TimTec1_000760 Cc1cccc(c1)C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C13 compound treatment 1.31110895E8 3310000.0 0.04 1.44358552E8 3970000.0 0.07 0.0773 0.972 3211047 TimTec1_000761 O=C(NN1C(=O)c2ccccc2C1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C14 compound treatment 1.3774139E8 9940000.0 0.12 1.66968962E8 2.66E7 0.45 0.4098 0.8688 1022870 TimTec1_000762 O=C(NCc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C15 compound treatment 1.5081641E8 2.3E7 0.29 1.27151158E8 -1.32E7 -0.23 0.0438 0.1195 3211048 TimTec1_000763 C(=N/c1cccnc1)\c2c[nH]c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C16 compound treatment 1.30003489E8 2200000.0 0.03 1.5624947E8 1.59E7 0.27 0.2114 0.775 1045873 TimTec1_000764 O=S(=O)(NCCc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C17 compound treatment 1.09031576E8 -1.88E7 -0.24 1.63622911E8 2.32E7 0.4 0.1147 0.2481 3211049 TimTec1_000765 Cc1c(/N=C/c2cccc(C)c2)c(=O)n(c3ccccc3)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C18 compound treatment 1.51075907E8 2.33E7 0.29 1.52948439E8 1.26E7 0.21 0.3584 0.9887 1634239 TimTec1_000766 O=C(CCCC(=O)Nc1cccc2ccccc12)Nc3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C19 compound treatment 7.7788764E7 -5.0E7 -0.63 9.4974446E7 -4.54E7 -0.78 -0.9934 -0.9943 3081336 TimTec1_000767 O=C(CSc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C20 compound treatment 1.3450519E8 6700000.0 0.08 1.63629929E8 2.32E7 0.4 0.3407 0.838 1173423 TimTec1_000768 CCOC(=O)C1=C(C(=O)c2ccccc2)C3(C(=O)Nc4ccccc43)C(=C(N)O1)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C21 compound treatment 8.9565671E7 -3.82E7 -0.48 1.50442449E8 1.01E7 0.17 -0.2175 -0.4269 1130405 TimTec1_000769 CC1(C)CC(=O)C2=C(C1)OC(=C(C#N)C32CCN(Cc4ccccc4)CC3)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C22 compound treatment 1.43508474E8 1.57E7 0.2 1.7666629E8 3.63E7 0.62 0.5784 0.8878 3211050 TimTec1_000770 Cc1cc(c2c(n1)sc3c(=O)[nH]c(C)nc32)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C23 mock treatment 1.2891771E8 1110000.0 0.01 1.23033143E8 -1.74E7 -0.3 -0.2002 -0.6731 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 C24 mock treatment 1.36515022E8 8710000.0 0.11 1.45642656E8 5250000.0 0.09 0.1408 0.9953 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D01 compound treatment 1.21598804E8 -6210000.0 -0.08 1.64410999E8 2.4E7 0.41 0.2357 0.5632 1332544 TimTec1_000771 CCCN1CCC2(CC1)C(C#N)C(=O)NC(=C2C#N)S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D02 compound treatment 1.26733616E8 -1070000.0 -0.01 1.64037947E8 2.36E7 0.4 0.2767 0.6833 1267101 TimTec1_000772 CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN4CCOCC4)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D03 compound treatment 1.54624786E8 2.68E7 0.34 1.6352835E8 2.31E7 0.4 0.5179 0.9967 3211051 TimTec1_000773 C(/N=C/C1=CSC=CN1c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D04 compound treatment 1.13839547E8 -1.4E7 -0.18 1.72800353E8 3.24E7 0.55 0.2684 0.4614 1527522 TimTec1_000774 S=c1n(CN2CCCCC2)nc(c3ccccc3)n1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D05 compound treatment 1.2819315E8 389000.0 0.0 1.49856141E8 9460000.0 0.16 0.118 0.7281 1323715 TimTec1_000775 CC1C=C(C)C2C(C)C1COC2c3ccc(OC(=O)NC4CCCCC4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D06 compound treatment 1.10418568E8 -1.74E7 -0.22 8.3743409E7 -5.66E7 -0.97 -0.8399 -0.845 1445377 TimTec1_000776 CC12CCC(C(=O)CO)C2(C)CCC3(C)C4(C)CCC(=O)C=C4CCC13C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D07 compound treatment 1.22110665E8 -5690000.0 -0.07 1.52200455E8 1.18E7 0.2 0.0924 0.4311 3209076 TimTec1_000777 FC(F)(F)c1cc(nc2cc(nn12)C(=O)N(Cc3ccccc3)Cc4ccccc4)c5ccco5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D08 compound treatment 1.03117659E8 -2.47E7 -0.31 1.72047657E8 3.17E7 0.54 0.1642 0.2631 1519326 TimTec1_000778 CCOC(=O)C1=C(CC2=C1CCCC2)NC(=S)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D09 compound treatment 1.37030514E8 9230000.0 0.12 1.5488378E8 1.45E7 0.25 0.2572 0.9398 1679838 TimTec1_000779 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D10 compound treatment 1.55016025E8 2.72E7 0.34 1.68917739E8 2.85E7 0.49 0.5867 0.9847 1574797 TimTec1_000780 CCCC(=O)Nc1ccc(N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D11 compound treatment 1.41611393E8 1.38E7 0.17 1.64949724E8 2.46E7 0.42 0.4197 0.9232 3209077 TimTec1_000781 CCOC(=O)c1c(NC(=O)OC)sc2CCCCc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D12 compound treatment 1.32860977E8 5060000.0 0.06 1.66445262E8 2.61E7 0.45 0.3602 0.7996 1560316 TimTec1_000782 CCOC(=O)c1ccc(NC(=O)c2ccc(cc2)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D13 compound treatment 1.36660926E8 8860000.0 0.11 1.54965246E8 1.46E7 0.25 0.255 0.9336 3081341 TimTec1_000783 Nc1nc(nc(n1)C(F)(F)F)N(Cc2ccccc2)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D14 compound treatment 9.5445109E7 -3.24E7 -0.41 1.47900911E8 7510000.0 0.13 -0.1962 -0.4607 3209078 TimTec1_000784 Cc1ccoc1CC[N+](C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D15 compound treatment 1.36005469E8 8200000.0 0.1 1.43698441E8 3310000.0 0.06 0.1128 0.9604 1672714 TimTec1_000785 COc1ccccc1CC(=O)N(CC=C)CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D16 compound treatment 1.11958714E8 -1.58E7 -0.2 1.61752658E8 2.14E7 0.37 0.118 0.2835 3209079 TimTec1_000786 C1COc2cccc(/C=N\n3cnnc3)c2OC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D17 compound treatment 1.35315089E8 7510000.0 0.09 1.06888597E8 -3.35E7 -0.57 -0.3389 -0.5831 3209080 TimTec1_000787 CCC(O)c1ccc2c(=O)c(coc2c1)c3ccccc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D18 compound treatment 8.9492032E7 -3.83E7 -0.48 1.40034727E8 -358000.0 -0.01 -0.3442 -0.7161 3209081 TimTec1_000788 Cc1c(/N=C/C(O)CN2CC3CC(C2)c4cccc(=O)n4C3)c(=O)n(c5ccccc5)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D19 compound treatment 1.09098314E8 -1.87E7 -0.23 1.28333087E8 -1.21E7 -0.21 -0.3119 -0.998 3081342 TimTec1_000789 CC(C)Cc1ccc(/C=C/C(=O)N2CCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D20 compound treatment 1.1238296E7 -1.17E8 -1.46 1.8174137E7 -1.22E8 -2.09 -2.5133 -0.9847 3081343 TimTec1_000790 CC(=O)N1CCCCC1c2cccnc2.[O-][N+](=O)O[Ag] 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D21 compound treatment 1.37549093E8 9740000.0 0.12 9.2249698E7 -4.81E7 -0.82 -0.4963 -0.5957 1588159 TimTec1_000791 CS(=O)(=O)Nc1ccc2CCc3cccc1c32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D22 compound treatment 1.02950405E8 -2.49E7 -0.31 1.37293272E8 -3100000.0 -0.05 -0.258 -0.8157 1287290 TimTec1_000792 COC(=O)c1c(C)nc(C)c2c(=O)oc3ccccc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D23 mock treatment 1.15746684E8 -1.21E7 -0.15 1.38343435E8 -2050000.0 -0.04 -0.1318 -0.8485 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 D24 mock treatment 1.21382139E8 -6420000.0 -0.08 1.38173845E8 -2220000.0 -0.04 -0.0838 -0.9411 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E01 compound treatment 1.10030754E8 -1.78E7 -0.22 1.09748356E8 -3.06E7 -0.52 -0.5286 -0.9274 1535367 TimTec1_000793 CCC(C)c1ccc(NC(=O)c2ccc(cc2)N(CC)CC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E02 compound treatment 1.05545125E8 -2.23E7 -0.28 1.11323423E8 -2.91E7 -0.5 -0.5493 -0.9627 1215550 TimTec1_000794 CC(C)(C)C(=O)Nc1ccccc1C(=O)N2CCN(Cc3ccccc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E03 compound treatment 1.20426852E8 -7380000.0 -0.09 1.00203377E8 -4.02E7 -0.69 -0.5519 -0.7951 1689344 TimTec1_000795 Clc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)Cc3ccccc3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E04 compound treatment 1.21454101E8 -6350000.0 -0.08 1.39019738E8 -1370000.0 -0.02 -0.0729 -0.8782 3209082 TimTec1_000796 O(c1ccccc1)c2ccc(/C=N/c3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E05 compound treatment 1.06360782E8 -2.14E7 -0.27 1.24126809E8 -1.63E7 -0.28 -0.3871 -0.9999 3081345 TimTec1_000797 NC(CSCc1oc(cc1C(=O)O)c2ccccc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E06 compound treatment 1.13348632E8 -1.45E7 -0.18 1.35453602E8 -4940000.0 -0.08 -0.188 -0.9397 1921518 TimTec1_000798 COc1ccc(NC(=O)/C=C/c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E07 compound treatment 1.25120443E8 -2680000.0 -0.03 1.48312632E8 7920000.0 0.14 0.0721 0.5158 1601233 TimTec1_000799 OC(=O)C1C(C2CCC1C2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E08 compound treatment 1.25558866E8 -2250000.0 -0.03 1.34482599E8 -5910000.0 -0.1 -0.0915 -0.8709 3081347 TimTec1_000800 CCOC1(C)OC2CCC(CC)OC2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E09 compound treatment 1.15837379E8 -1.2E7 -0.15 1.13412956E8 -2.7E7 -0.46 -0.4327 -0.8911 3082473 TimTec1_000801 CCc1ccc(cc1)C(=O)CSc2nnc(c3cccc(OC)c3)n2CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E10 compound treatment 1.15917389E8 -1.19E7 -0.15 1.28344609E8 -1.2E7 -0.21 -0.2513 -0.9873 3082474 TimTec1_000802 COc1cc(/N=C/c2cc3cccc(C)c3nc2Cl)c(OC)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E11 compound treatment 9.6838807E7 -3.1E7 -0.39 1.48189075E8 7800000.0 0.13 -0.1803 -0.439 3209083 TimTec1_000803 CCCC[n+]1cc(nc(n1)N2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E12 compound treatment 1.18869017E8 -8940000.0 -0.11 1.03403376E8 -3.7E7 -0.63 -0.527 -0.8195 3209084 TimTec1_000804 O=C(Cc1ccccc1)NC2CCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E13 compound treatment 1.34411097E8 6610000.0 0.08 1.23058996E8 -1.73E7 -0.3 -0.1512 -0.4908 1914322 TimTec1_000805 Clc1ccc(/N=C/c2c[nH]c3ccccc23)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E14 compound treatment 7.6246741E7 -5.16E7 -0.65 9.2978553E7 -4.74E7 -0.81 -1.0312 -0.9937 1916639 TimTec1_000806 O=C(c1ccccc1)n2cnc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E15 compound treatment 1.45045832E8 1.72E7 0.22 1.22938259E8 -1.75E7 -0.3 -0.0583 -0.1581 1607222 TimTec1_000807 COc1ccc(cc1)C2(Cc3nc4ccccc4[nH]3)C(=O)c5ccccc5C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E16 compound treatment 1.38523256E8 1.07E7 0.13 1.4982036E8 9430000.0 0.16 0.2092 0.9959 1418431 TimTec1_000808 O=S(=O)(NC(c1ccccc1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E17 compound treatment 1.29310925E8 1510000.0 0.02 1.34650866E8 -5740000.0 -0.1 -0.0561 -0.5609 3082475 TimTec1_000809 Fc1ccc(/C=N/c2ccc(I)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E18 compound treatment 1.33227216E8 5420000.0 0.07 1.54444194E8 1.41E7 0.24 0.2182 0.8728 1450437 TimTec1_000810 COC(=O)c1cc(NS(=O)(=O)c2ccccc2)cc(c1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E19 compound treatment 1.15374455E8 -1.24E7 -0.16 1.3013256E8 -1.03E7 -0.18 -0.2344 -0.9982 1573675 TimTec1_000811 O=C(C1c2ccccc2Oc3ccccc13)N4CCCc5ccccc45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E20 compound treatment 9.7829376E7 -3.0E7 -0.38 1.36152421E8 -4240000.0 -0.07 -0.3172 -0.8283 1156098 TimTec1_000812 NC1=C(C(=O)OCc2ccccc2)C3(C(=O)Nc4ccc(Br)cc43)C5=C(O1)C(=O)CCC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E21 compound treatment 1.06627649E8 -2.12E7 -0.27 1.25824238E8 -1.46E7 -0.25 -0.3642 -0.9995 1774639 TimTec1_000813 [O-][n+]1onc2c3cc([nH]c3ccc12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E22 compound treatment 1.07593132E8 -2.02E7 -0.25 1.30216227E8 -1.02E7 -0.17 -0.3025 -0.9832 1601319 TimTec1_000814 CCOc1ccc(cc1)C2(C)CC(C)(C)Nc3ccccc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E23 mock treatment 1.14518808E8 -1.33E7 -0.17 9.0873699E7 -4.95E7 -0.85 -0.7172 -0.8302 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 E24 mock treatment 9.1800151E7 -3.6E7 -0.45 1.45271916E8 4880000.0 0.08 -0.2603 -0.5667 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F01 compound treatment 1.19111833E8 -8690000.0 -0.11 1.35774974E8 -4620000.0 -0.08 -0.133 -0.9875 3209085 TimTec1_000815 Oc1n[nH]c(c1C(C(C#N)C#N)c2ccsc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F02 compound treatment 1.09070736E8 -1.87E7 -0.24 1.37414779E8 -2980000.0 -0.05 -0.2022 -0.8409 1492048 TimTec1_000816 C(C1NCC=N1)c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F03 compound treatment 9.8190048E7 -2.96E7 -0.37 1.02808587E8 -3.76E7 -0.64 -0.7176 -0.9659 3209086 TimTec1_000817 O=c/1[nH]c2ccccc2[nH]\c1=N/C(=S)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F04 compound treatment 7.7553055E7 -5.03E7 -0.63 1.1952301E8 -2.09E7 -0.36 -0.6984 -0.9638 1173360 TimTec1_000818 COc1ccc(cc1OC)C(=O)NC(CO)(CO)CO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F05 compound treatment 8.4473501E7 -4.33E7 -0.54 8.6908835E7 -5.35E7 -0.92 -1.0317 -0.969 1399424 TimTec1_000819 C1C2C(Oc3ccccc3C2Oc4ccccc14)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F06 compound treatment 7.2700506E7 -5.51E7 -0.69 1.13173065E8 -2.72E7 -0.47 -0.8183 -0.9816 1110045 TimTec1_000820 CN(C1CCCCC1)S(=O)(=O)c2ccc(N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F07 compound treatment 1.24047213E8 -3760000.0 -0.05 8.5189763E7 -5.52E7 -0.94 -0.7015 -0.7415 3209087 TimTec1_000821 CC(C)C1=C2CCCCC2NC(=O)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F08 compound treatment 8.7443091E7 -4.04E7 -0.51 1.10302688E8 -3.01E7 -0.52 -0.7222 -1.0 1005088 TimTec1_000822 COC(=O)c1cc(C(=O)OC)c(cc1C(=O)OC)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F09 compound treatment 8.3196787E7 -4.46E7 -0.56 8.8442416E7 -5.19E7 -0.89 -1.0245 -0.9751 1428753 TimTec1_000823 CC(=O)Nc1ccc(cc1)S(=O)(=O)n2cnc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F10 compound treatment 7.6554321E7 -5.13E7 -0.64 1.35044326E8 -5350000.0 -0.09 -0.5193 -0.7997 1121309 TimTec1_000824 CCCC(=O)Nc1cccc(N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F11 compound treatment 1.05404149E8 -2.24E7 -0.28 1.17160707E8 -2.32E7 -0.4 -0.4799 -0.9855 1703558 TimTec1_000825 NC1=C(C#N)C2=CCCCC2C3(C(=O)N(Cc4ccccc4)c5ccccc53)C1(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F12 compound treatment 8.7753587E7 -4.01E7 -0.5 9.0606414E7 -4.98E7 -0.85 -0.9579 -0.9682 1304433 TimTec1_000826 CN(C)CC#CC1(O)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F13 compound treatment 8.1485137E7 -4.63E7 -0.58 1.23084136E8 -1.73E7 -0.3 -0.6204 -0.9511 3209088 TimTec1_000827 CN(C)c1ccc(/C=C/2\CSC(=S)NC2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F14 compound treatment 7.4543796E7 -5.33E7 -0.67 9.2962278E7 -4.74E7 -0.81 -1.0465 -0.9953 3082476 TimTec1_000828 CC/1(OCO\C1=C/C[N+](C)(C)C)C=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F15 compound treatment 8.5238074E7 -4.26E7 -0.53 8.1684427E7 -5.87E7 -1.0 -1.0882 -0.9562 3209089 TimTec1_000829 COc1ccccc1CC(=O)N2CCCC(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F16 compound treatment 8.1633258E7 -4.62E7 -0.58 1.03864196E8 -3.65E7 -0.63 -0.8517 -0.9993 3082477 TimTec1_000830 C(=N/n1cnnc1)\c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F17 compound treatment 1.15679578E8 -1.21E7 -0.15 1.38483603E8 -1910000.0 -0.03 -0.1307 -0.8398 1177709 TimTec1_000831 CCc1cc(c2n[nH]cc2c3nc(C)cs3)c(O)cc1OC(C)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F18 compound treatment 9.8935242E7 -2.89E7 -0.36 7.4126037E7 -6.63E7 -1.13 -1.0582 -0.8887 3082478 TimTec1_000832 Cc1c(/N=C\C2CCCN3CCCCC23)c(=O)n(c4ccccc4)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F19 compound treatment 8.5820536E7 -4.2E7 -0.53 8.3706096E7 -5.67E7 -0.97 -1.0586 -0.9588 3209090 TimTec1_000833 COc1cc(Br)cc(CNc2cc(C)on2)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F20 compound treatment 1.20601885E8 -7200000.0 -0.09 8.8803653E7 -5.16E7 -0.88 -0.6883 -0.7754 3209091 TimTec1_000834 O=C(/C=C/c1ccccc1)N2CCCCC2c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F21 compound treatment 7.8801448E7 -4.9E7 -0.61 7.3102352E7 -6.73E7 -1.15 -1.2492 -0.9568 3082479 TimTec1_000835 COc1ccc(NC(=S)SC)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F22 compound treatment 1.10311813E8 -1.75E7 -0.22 9.7778783E7 -4.26E7 -0.73 -0.671 -0.8808 1375719 TimTec1_000836 CCCC1=C(C(NC(=O)N1)c2cc(Br)c(O)c(OC)c2)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F23 mock treatment 1.18304491E8 -9500000.0 -0.12 1.32856282E8 -7540000.0 -0.13 -0.1755 -0.9992 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 F24 mock treatment 1.17049295E8 -1.08E7 -0.13 1.34393238E8 -6000000.0 -0.1 -0.168 -0.9909 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G01 compound treatment 1.36483263E8 8680000.0 0.11 1.6500773E8 2.46E7 0.42 0.3749 0.8615 1641121 TimTec1_000837 CCC(C)NC(=O)c1ccc(cc1)N(CC)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G02 compound treatment 1.41515754E8 1.37E7 0.17 1.7577649E8 3.54E7 0.61 0.5499 0.8734 1504788 TimTec1_000838 Clc1cccc(c1)c2nc3n(ncc3c(=O)o2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G03 compound treatment 1.46548246E8 1.87E7 0.24 1.80496323E8 4.01E7 0.69 0.6517 0.8981 1392995 TimTec1_000839 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G04 compound treatment 1.77343583E8 4.95E7 0.62 1.76640206E8 3.62E7 0.62 0.8782 1.0 1261047 TimTec1_000840 O=C1NC(C(N1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G05 compound treatment 1.52621406E8 2.48E7 0.31 1.76419143E8 3.6E7 0.62 0.6562 0.9499 3082481 TimTec1_000841 Sc1nccn1CCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G06 compound treatment 1.55000105E8 2.72E7 0.34 1.79535496E8 3.91E7 0.67 0.715 0.951 1044409 TimTec1_000842 O=C(Nc1ccccc1)C(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G07 compound treatment 1.55427184E8 2.76E7 0.35 1.67021051E8 2.66E7 0.46 0.5673 0.9908 1679314 TimTec1_000843 NC(=O)C1C(C2CCC1C2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G08 compound treatment 1.48798888E8 2.1E7 0.26 1.75168384E8 3.48E7 0.6 0.6072 0.9327 3082485 TimTec1_000844 Clc1ccc(/N=C/c2ccc(Br)o2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G09 compound treatment 1.47818706E8 2.0E7 0.25 1.0961249E8 -3.08E7 -0.53 -0.195 -0.3342 1181154 TimTec1_000845 O=c1n(c(SCc2ccc3OCOc3c2)nc4ccccc14)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G10 compound treatment 1.59451059E8 3.16E7 0.4 1.26181763E8 -1.42E7 -0.24 0.1087 0.2335 3082487 TimTec1_000846 Cc1ccc(/N=C/c2cc3ccccc3nc2Cl)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G11 compound treatment 1.3515472E8 7350000.0 0.09 1.40346438E8 -45800.0 0.0 0.0646 0.7011 1384410 TimTec1_000847 CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(nc(nn12)N3CCOCC3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G12 compound treatment 1.61567349E8 3.38E7 0.42 1.10614917E8 -2.98E7 -0.51 -0.0609 -0.092 1271027 TimTec1_000848 COc1ccc(CC(=O)NCC(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G13 compound treatment 1.57431659E8 2.96E7 0.37 1.22540841E8 -1.79E7 -0.31 0.0467 0.0971 3209212 TimTec1_000849 Cc1ccc(/N=C/c2c[nH]c3ccccc23)nc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G14 compound treatment 1.60388443E8 3.26E7 0.41 1.89354585E8 4.9E7 0.84 0.8817 0.9455 1290233 TimTec1_000850 Brc1ccc(cc1)S(=O)(=O)N2CCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G15 compound treatment 9.7133621E7 -3.07E7 -0.38 2.04786198E8 6.44E7 1.1 0.5074 0.4346 3209213 TimTec1_000851 CCCNc1nc(Cl)nc(NCCC)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G16 compound treatment 1.5214116E8 2.43E7 0.31 1.84311705E8 4.39E7 0.75 0.7475 0.9212 1275135 TimTec1_000852 O=S(=O)(N(c1ccccc1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G17 compound treatment 1.5086691E8 2.31E7 0.29 1.06012536E8 -3.44E7 -0.59 -0.2116 -0.3226 3209214 TimTec1_000853 NS(=O)(=O)c1ccc(/N=C/c2c(O)ccc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G18 compound treatment 1.48329737E8 2.05E7 0.26 1.7742417E8 3.7E7 0.63 0.6303 0.9212 3082492 TimTec1_000854 COc1ccc(OC)c(NS(=O)(=O)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G19 compound treatment 9.5208328E7 -3.26E7 -0.41 1.10037733E8 -3.04E7 -0.52 -0.6566 -0.993 3209215 TimTec1_000855 Cc1cc(nn1CC(=O)Nc2sc(C)c(C)c2C(=O)N)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G20 compound treatment 1.17812319E8 -9990000.0 -0.13 2.11945649E8 7.16E7 1.22 0.7775 0.6314 1545537 TimTec1_000856 Cc1cc(C)c2oc(nc2c1)c3ccc(NC(=O)COc4ccc(Br)cc4)cc3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G21 compound treatment 1.38200861E8 1.04E7 0.13 1.16393486E8 -2.4E7 -0.41 -0.1983 -0.46 1150900 TimTec1_000857 On1c(nc-2c1CCc3nonc32)c4ccccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G22 compound treatment 1.60198599E8 3.24E7 0.41 1.27156459E8 -1.32E7 -0.23 0.1271 0.2733 3082530 TimTec1_000858 Cc1cc(C)c(C#N)c(SCc2cc(O)[nH]n2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G23 mock treatment 9.3956035E7 -3.38E7 -0.42 1.69351776E8 2.9E7 0.5 0.0503 0.077 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 G24 mock treatment 1.70827671E8 4.3E7 0.54 1.74837466E8 3.44E7 0.59 0.7986 0.999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H01 compound treatment 9.1046235E7 -3.68E7 -0.46 1.85916927E8 4.55E7 0.78 0.225 0.2485 1198410 TimTec1_000859 Cc1[nH]nc(O)c1C2(C(C#N)C#N)C3CC4CC(C3)CC2C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H02 compound treatment 1.80242897E8 5.24E7 0.66 1.52387739E8 1.2E7 0.21 0.6103 0.8857 3209216 TimTec1_000860 Cc1ccc(OCc2nnc(S)n2c3ccccc3)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H03 compound treatment 1.64601765E8 3.68E7 0.46 1.0784002E8 -3.26E7 -0.56 -0.0676 -0.0934 1739416 TimTec1_000861 CCN(CC)c1[nH]nnc1c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H04 compound treatment 1.04963328E8 -2.28E7 -0.29 1.15101424E8 -2.53E7 -0.43 -0.5087 -0.9799 3082533 TimTec1_000862 CCOC(=O)c1ccc(SC)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H05 compound treatment 1.21160969E8 -6640000.0 -0.08 1.17071E8 -2.33E7 -0.4 -0.3412 -0.8367 1302286 TimTec1_000863 O=C(C1CC2CCC1C2)N3CCN(CC3)c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H06 compound treatment 1.04742002E8 -2.31E7 -0.29 1.8616986E8 4.58E7 0.78 0.3495 0.4184 1696584 TimTec1_000864 COc1ccc(cc1)C2OC(=O)c3ccccc3S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H07 compound treatment 1.53854513E8 2.6E7 0.33 1.58178532E8 1.78E7 0.3 0.4464 0.9994 1246999 TimTec1_000865 CC1C=C(C)C2C(C)C1(COC(=O)NC3CCCCC3)COC42CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H08 compound treatment 1.73752606E8 4.59E7 0.58 1.1247398E8 -2.79E7 -0.48 0.0696 0.093 3209217 TimTec1_000866 Sc1nnc(COc2ccccc2)n1CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H09 compound treatment 1.84905915E8 5.71E7 0.72 1.34514575E8 -5880000.0 -0.1 0.4354 0.6019 1579810 TimTec1_000867 Clc1ccc(cc1)C(=O)N2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H10 compound treatment 1.71216081E8 4.34E7 0.54 1.19165007E8 -2.12E7 -0.36 0.1281 0.1957 1114790 TimTec1_000868 Cc1ccc(OCC(=O)O)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H11 compound treatment 1.61378002E8 3.36E7 0.42 1.71830583E8 3.14E7 0.54 0.6783 0.9926 1201078 TimTec1_000869 COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H12 compound treatment 1.62613101E8 3.48E7 0.44 1.07241055E8 -3.32E7 -0.57 -0.0925 -0.1292 1549339 TimTec1_000870 CC(O)(C#CCN1CCOCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H13 compound treatment 1.28765844E8 961000.0 0.01 1.72165915E8 3.18E7 0.54 0.3931 0.7226 3209218 TimTec1_000871 Clc1ccccc1/C=C/2\SC3NC(=NN3C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H14 compound treatment 1.22496962E8 -5310000.0 -0.07 1.30521783E8 -9870000.0 -0.17 -0.1666 -0.9171 3082538 TimTec1_000872 CC/1(C)OC(=O)N(\C1=C/C[N+](C)(C)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H15 compound treatment 1.524758E8 2.47E7 0.31 1.21182888E8 -1.92E7 -0.33 -0.0137 -0.0303 1740713 TimTec1_000873 COc1ccccc1CC(=O)Nc2cccc(NC(=O)C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H16 compound treatment 1.35607917E8 7800000.0 0.1 1.08569718E8 -3.18E7 -0.54 -0.316 -0.5709 1298167 TimTec1_000874 CC(=C1C(=O)NC(=O)NC1=O)c2ccc(N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H17 compound treatment 1.00228313E8 -2.76E7 -0.35 1.1224448E8 -2.81E7 -0.48 -0.5853 -0.9868 3209219 TimTec1_000875 Fc1ccc(cc1)S(=O)(=O)N(C2CCS(=O)(=O)C2)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H18 compound treatment 9.9712358E7 -2.81E7 -0.35 1.10984852E8 -2.94E7 -0.5 -0.6051 -0.9848 1208196 TimTec1_000876 O=C(N1CC2CC(C1)c3cccc(=O)n3C2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H19 compound treatment 1.36925966E8 9120000.0 0.11 9.6477278E7 -4.39E7 -0.75 -0.4506 -0.5927 3082542 TimTec1_000877 CC(=O)NCCOc1c(C)cccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H20 compound treatment 1.64058647E8 3.63E7 0.45 1.35397616E8 -4990000.0 -0.09 0.2611 0.5643 3082544 TimTec1_000878 COc1ccc(OCCSc2nc3ccccc3n2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H21 compound treatment 1.61410532E8 3.36E7 0.42 1.73751062E8 3.34E7 0.57 0.7019 0.9889 1488809 TimTec1_000879 CC1CCCCN1S(=O)(=O)c2ccc(NC(=O)C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H22 compound treatment 1.63642458E8 3.58E7 0.45 1.38272206E8 -2120000.0 -0.04 0.2922 0.6479 1442845 TimTec1_000880 C(Sc1nc(c(o1)c2ccccc2)c3ccccc3)C4COc5ccccc5O4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H23 mock treatment 1.501891E8 2.24E7 0.28 1.70964406E8 3.06E7 0.52 0.5686 0.9574 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 H24 mock treatment 1.68282131E8 4.05E7 0.51 1.67851565E8 2.75E7 0.47 0.6914 0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I01 compound treatment 1.32999589E8 5190000.0 0.07 1.25099807E8 -1.53E7 -0.26 -0.139 -0.5153 1191196 TimTec1_000881 Cc1ccc(NC(=O)CC(c2ccccc2)c3ccccc3)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I02 compound treatment 1.23384417E8 -4420000.0 -0.06 1.04600453E8 -3.58E7 -0.61 -0.4724 -0.768 3082580 TimTec1_000882 O=c1oc(nc2sc3CCCCCc3c12)c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I03 compound treatment 1.25773141E8 -2030000.0 -0.03 1.5348109E8 1.31E7 0.22 0.1404 0.6227 1319708 TimTec1_000883 Cc1cc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCOCC3)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I04 compound treatment 1.27761289E8 -43300.0 0.0 1.37676155E8 -2720000.0 -0.05 -0.0333 -0.7153 1427613 TimTec1_000884 Nc1ccc(cc1)C(C2NC(=O)c3ccccc23)c4ccc(N)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I05 compound treatment 1.21463776E8 -6340000.0 -0.08 1.24807913E8 -1.56E7 -0.27 -0.2449 -0.8797 1467312 TimTec1_000885 Cc1ccccc1NC(=O)CCC(=O)OC2CCC(CC2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I06 compound treatment 1.25722316E8 -2080000.0 -0.03 1.34616868E8 -5780000.0 -0.1 -0.0884 -0.8643 1018245 TimTec1_000886 CCN(CC)C(=O)C(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I07 compound treatment 1.26380794E8 -1420000.0 -0.02 1.14426765E8 -2.6E7 -0.44 -0.3269 -0.7349 1540337 TimTec1_000887 O=C(C1C(C#N)C2CCC1C2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I08 compound treatment 1.07513829E8 -2.03E7 -0.25 1.20854942E8 -1.95E7 -0.33 -0.4165 -0.9909 3082583 TimTec1_000888 OC(=O)c1ccccc1/N=C/c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I09 compound treatment 1.17003528E8 -1.08E7 -0.14 1.45256147E8 4860000.0 0.08 -0.0369 -0.2323 3209220 TimTec1_000889 Cn1c(SCc2ccc3OCOc3c2)nnc1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I10 compound treatment 1.22624084E8 -5180000.0 -0.06 1.16849014E8 -2.35E7 -0.4 -0.3309 -0.8107 3082586 TimTec1_000890 COC(=O)Nc1ccc(/N=C/c2cccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I11 compound treatment 1.32380214E8 4580000.0 0.06 1.45250875E8 4860000.0 0.08 0.0994 0.9836 3209221 TimTec1_000891 COc1nncc(n1)c2cnnc(SC)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I12 compound treatment 1.41919844E8 1.41E7 0.18 1.36802071E8 -3590000.0 -0.06 0.0818 0.4362 1639601 TimTec1_000892 COc1ccc(CC(=O)NN2CCN(CC2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I13 compound treatment 1.49291856E8 2.15E7 0.27 1.61407436E8 2.1E7 0.36 0.445 0.9899 3209222 TimTec1_000893 C1CCC(=Nn2cnnc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I14 compound treatment 1.50516362E8 2.27E7 0.28 1.56756648E8 1.64E7 0.28 0.3995 1.0 1554764 TimTec1_000894 CN1CCN(CC1)S(=O)(=O)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I15 compound treatment 1.58685185E8 3.09E7 0.39 1.74673248E8 3.43E7 0.59 0.6889 0.9797 3209223 TimTec1_000895 CCOc1ccc2nc(/N=C/c3ccccc3O)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I16 compound treatment 1.43832937E8 1.6E7 0.2 1.69146431E8 2.88E7 0.49 0.4902 0.922 1340130 TimTec1_000896 CC(=O)Nc1cccc(NS(=O)(=O)c2ccc(C)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I17 compound treatment 1.63115577E8 3.53E7 0.44 1.86622087E8 4.62E7 0.79 0.8728 0.9624 1912630 TimTec1_000897 CCOC(=O)c1ccc(/N=C/c2ccccc2O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I18 compound treatment 1.51889472E8 2.41E7 0.3 1.70318061E8 2.99E7 0.51 0.5759 0.9683 1423694 TimTec1_000898 COC(=O)c1ccc(C(=O)OC)c(NC(=O)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I19 compound treatment 1.39386477E8 1.16E7 0.15 1.61587736E8 2.12E7 0.36 0.3593 0.9193 3082591 TimTec1_000899 Nc1c(C#N)sc2nc(ccc12)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I20 compound treatment 1.46374544E8 1.86E7 0.23 1.72763449E8 3.24E7 0.55 0.5565 0.9259 3209224 TimTec1_000900 CSc1ccc(/N=C/N2C(=O)c3ccccc3C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I21 compound treatment 1.39664047E8 1.19E7 0.15 1.54201109E8 1.38E7 0.24 0.2723 0.9751 3082593 TimTec1_000901 Oc1[nH]c(=S)[nH]c(=O)c1CN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I22 compound treatment 1.20244652E8 -7560000.0 -0.09 1.57582248E8 1.72E7 0.29 0.141 0.4561 3209346 TimTec1_000902 O=C([C@H]1[C@H](c2cccs2)C(C#N)(C#N)[C@H]3N1C=Cc4ccccc34)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I23 mock treatment 1.61892598E8 3.41E7 0.43 1.64142782E8 2.38E7 0.41 0.5899 0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 I24 mock treatment 1.73346192E8 4.55E7 0.57 1.50050421E8 9660000.0 0.17 0.5209 0.8758 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J01 compound treatment 1.16091996E8 -1.17E7 -0.15 1.67205881E8 2.68E7 0.46 0.2207 0.4579 1633418 TimTec1_000903 Oc1cc(O)c2sc3nc(ccc3c2n1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J02 compound treatment 1.36930089E8 9130000.0 0.11 1.11185236E8 -2.92E7 -0.5 -0.2726 -0.5315 1297117 TimTec1_000904 Nc1ccc(cc1)c2cc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J03 compound treatment 1.29657922E8 1850000.0 0.02 1.24729034E8 -1.57E7 -0.27 -0.1732 -0.6434 3082596 TimTec1_000905 Sc1n[nH]nc1c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J04 compound treatment 1.27951545E8 147000.0 0.0 1.32412764E8 -7980000.0 -0.14 -0.0953 -0.6975 3209347 TimTec1_000906 CCOC(=O)c1ccc(cc1)S(=O)(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J05 compound treatment 1.3682879E8 9020000.0 0.11 1.63593503E8 2.32E7 0.4 0.3609 0.8739 1207815 TimTec1_000907 CC1C=C(C)C2C(C)C1COC2c3ccccc3OCc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J06 compound treatment 1.3488752E8 7080000.0 0.09 1.50311795E8 9920000.0 0.17 0.1829 0.9544 1614670 TimTec1_000908 CC1CCCCN1S(=O)(=O)c2ccc(N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J07 compound treatment 1.2582775E8 -1980000.0 -0.02 1.54109845E8 1.37E7 0.23 0.1485 0.6289 1620705 TimTec1_000909 CC1CC2=C(CC1(CO)CO)C(C)(C)CCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J08 compound treatment 1.77797883E8 5.0E7 0.63 1.79910392E8 3.95E7 0.68 0.9218 0.9993 1432678 TimTec1_000910 Nc1cccc(c1)c2nc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J09 compound treatment 1.38788026E8 1.1E7 0.14 1.47186298E8 6790000.0 0.12 0.1797 0.9964 1679574 TimTec1_000911 Brc1ccc(cc1)C(=O)N2CCC(Cc3ccccc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J10 compound treatment 1.81561185E8 5.38E7 0.67 1.91803752E8 5.14E7 0.88 1.0991 0.9914 1513995 TimTec1_000912 CCCc1ccc(O)c(N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J11 compound treatment 1.25762762E8 -2040000.0 -0.03 1.31174781E8 -9220000.0 -0.16 -0.1297 -0.8113 1491173 TimTec1_000913 CC(=O)OC1CCC2(C)C3CCC4(C)C(CCC4=O)C3CC=C2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J12 compound treatment 1.54343577E8 2.65E7 0.33 1.63223427E8 2.28E7 0.39 0.5118 0.9968 3082639 TimTec1_000914 OC1(CCCCC1)/C=C/CN2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J13 compound treatment 1.29863115E8 2060000.0 0.03 1.58261498E8 1.79E7 0.31 0.2346 0.7641 3179906 TimTec1_000915 CC[C@]1(CCCN2CC[C@]3([C@H]4CC1)c5cccc(OC)c5N4C(=O)C)[C@@H]23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J14 compound treatment 1.42164095E8 1.44E7 0.18 1.79725101E8 3.93E7 0.67 0.6035 0.8658 3082641 TimTec1_000916 CC1=[N+](CCC#N)c2ccccc2C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J15 compound treatment 1.39176301E8 1.14E7 0.14 1.5269386E8 1.23E7 0.21 0.2498 0.982 1205123 TimTec1_000917 Cc1cccc(SCC(=O)Nc2ccc3OCCOc3c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J16 compound treatment 1.47830406E8 2.0E7 0.25 1.76816731E8 3.64E7 0.62 0.6185 0.9201 3082643 TimTec1_000918 SC(=S)N1CCCCC1c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J17 compound treatment 1.42867232E8 1.51E7 0.19 1.47324714E8 6930000.0 0.12 0.2175 0.9749 3209348 TimTec1_000919 CCOc1ccc(cc1)C(=O)CC(N)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J18 compound treatment 1.41375208E8 1.36E7 0.17 1.34948196E8 -5440000.0 -0.09 0.0545 0.2807 1146682 TimTec1_000920 O=C1N(CCN2CC3CC(C2)c4cccc(=O)n4C3)C(=O)c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J19 compound treatment 1.26836785E8 -968000.0 -0.01 1.50061384E8 9670000.0 0.17 0.1085 0.6535 1708504 TimTec1_000921 NCCOc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J20 compound treatment 1.52996808E8 2.52E7 0.32 1.65650413E8 2.53E7 0.43 0.5292 0.9881 1179648 TimTec1_000922 CN(C)c1ccc(cc1)C2NC(=S)NC(=C2C(=O)OCCc3ccccc3)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J21 compound treatment 1.27805135E8 534.0 0.0 1.49536293E8 9140000.0 0.16 0.1107 0.7071 3082646 TimTec1_000923 NC(=N)SCc1csc(N)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J22 compound treatment 1.28485507E8 681000.0 0.01 1.43911995E8 3520000.0 0.06 0.0486 0.7994 3082648 TimTec1_000924 C(Sc1cccc2cccnc12)c3nnc(o3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J23 mock treatment 1.36837832E8 9030000.0 0.11 1.61663488E8 2.13E7 0.36 0.3376 0.8853 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 J24 mock treatment 1.60653757E8 3.28E7 0.41 1.68904451E8 2.85E7 0.49 0.6365 0.9965 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K01 compound treatment 1.051065E8 -2.27E7 -0.28 1.3093091E8 -9460000.0 -0.16 -0.3159 -0.9642 1262368 TimTec1_000925 CC(C)(C)NC(=O)CC(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K02 compound treatment 1.07625302E8 -2.02E7 -0.25 1.33319892E8 -7070000.0 -0.12 -0.2646 -0.943 1207448 TimTec1_000926 CCc1nc2n(ncc2c(=O)n1CCc3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K03 compound treatment 1.08402533E8 -1.94E7 -0.24 1.2855715E8 -1.18E7 -0.2 -0.3154 -0.9958 1458877 TimTec1_000927 COc1ccc(cc1S(=O)(=O)Nc2ccc(Cl)cc2)C(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K04 compound treatment 1.13202281E8 -1.46E7 -0.18 1.26552508E8 -1.38E7 -0.24 -0.297 -0.9919 3082651 TimTec1_000928 COc1ccc(cc1N)S(=O)(=O)C=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K05 compound treatment 1.28680277E8 876000.0 0.01 1.49877333E8 9490000.0 0.16 0.1226 0.7532 3209349 TimTec1_000929 O=C1CCCC(Cn2cncn2)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K06 compound treatment 1.31542463E8 3740000.0 0.05 1.44192526E8 3800000.0 0.07 0.0792 0.9871 1111413 TimTec1_000930 O=C(N(c1ccccc1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K07 compound treatment 1.25960297E8 -1840000.0 -0.02 9.3627609E7 -4.68E7 -0.8 -0.5824 -0.7272 3082653 TimTec1_000931 CCC1=CC(NC(=S)N1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K08 compound treatment 1.41439015E8 1.36E7 0.17 1.80588169E8 4.02E7 0.69 0.6075 0.8568 3209350 TimTec1_000932 Oc1ccccc1/C=N/c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K09 compound treatment 1.38839851E8 1.1E7 0.14 1.59780529E8 1.94E7 0.33 0.3326 0.9248 3082655 TimTec1_000933 CCc1ccc(OCCNC(=O)c2ccco2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K10 compound treatment 1.35344196E8 7540000.0 0.09 1.76472355E8 3.61E7 0.62 0.5036 0.806 1604140 TimTec1_000934 Clc1ccc(cc1)S(=O)(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K11 compound treatment 1.13931599E8 -1.39E7 -0.17 1.21192748E8 -1.92E7 -0.33 -0.3555 -0.9558 1651876 TimTec1_000935 CNC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K12 compound treatment 1.37228934E8 9420000.0 0.12 9.9308226E7 -4.11E7 -0.7 -0.4137 -0.5801 3082657 TimTec1_000936 Cc1onc(c1C(=O)NC2=NCCS2)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K13 compound treatment 1.94443129E8 6.66E7 0.84 1.41798303E8 1410000.0 0.02 0.6081 0.7272 3209351 TimTec1_000937 Clc1ccc(/C=N\n2cnnc2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K14 compound treatment 1.46484219E8 1.87E7 0.23 1.09117213E8 -3.13E7 -0.54 -0.2129 -0.3642 1479829 TimTec1_000938 Brc1ccc(cc1)S(=O)(=O)NCC2CCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K15 compound treatment 1.14244426E8 -1.36E7 -0.17 1.53895479E8 1.35E7 0.23 0.0432 0.1504 3209352 TimTec1_000939 COc1ccc(/C=N/c2ccc(Br)cc2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K16 compound treatment 1.37514806E8 9710000.0 0.12 1.51091867E8 1.07E7 0.18 0.2156 0.9804 1308008 TimTec1_000940 CCN(c1ccccc1)S(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K17 compound treatment 1.59655093E8 3.19E7 0.4 1.05093814E8 -3.53E7 -0.6 -0.1447 -0.1998 1918619 TimTec1_000941 CCOC(=O)c1ccc(/N=C/c2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K18 compound treatment 1.44773094E8 1.7E7 0.21 9.1216614E7 -4.92E7 -0.84 -0.4447 -0.5122 1453153 TimTec1_000942 COC(=O)c1cc(NC(=O)c2ccco2)cc(c1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K19 compound treatment 9.1176492E7 -3.66E7 -0.46 9.0097404E7 -5.03E7 -0.86 -0.9337 -0.9568 3209353 TimTec1_000943 Nc1nc2c3cc4CCCc4nc3sc2c(c1C#N)c5ccc(Br)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K20 compound treatment 1.31492877E8 3690000.0 0.05 1.03536632E8 -3.69E7 -0.63 -0.4134 -0.6535 1246610 TimTec1_000944 Cc1cccc(N2C(=O)c3ccc(cc3C2=O)C(=O)Nc4c[nH]c(=O)[nH]c4=O)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K21 compound treatment 1.15677763E8 -1.21E7 -0.15 1.44201905E8 3810000.0 0.07 -0.0615 -0.3713 1512817 TimTec1_000945 Cc1ccc(cc1)n2c(C)nc3sc4CCCc4c3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K22 compound treatment 1.37532996E8 9730000.0 0.12 1.02162042E8 -3.82E7 -0.65 -0.3765 -0.5655 3209354 TimTec1_000946 NC(=O)C(C(C(C#N)C#N)c1ccccc1Cl)[n+]2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K23 mock treatment 1.3133746E8 3530000.0 0.04 9.6014646E7 -4.44E7 -0.76 -0.5058 -0.6647 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 K24 mock treatment 1.25685004E8 -2120000.0 -0.03 1.59460592E8 1.91E7 0.33 0.212 0.6474 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L01 compound treatment 9.9479444E7 -2.83E7 -0.36 8.5685664E7 -5.47E7 -0.94 -0.9134 -0.912 1381598 TimTec1_000947 NC(=O)c1c(c(C#N)c(N)[nH]c1=S)c2cccc(Br)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L02 compound treatment 8.0920422E7 -4.69E7 -0.59 1.31055003E8 -9340000.0 -0.16 -0.5289 -0.8678 1609999 TimTec1_000948 COC(=O)C1CCCN1S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L03 compound treatment 7.9340327E7 -4.85E7 -0.61 8.639719E7 -5.4E7 -0.92 -1.0835 -0.9793 1730347 TimTec1_000949 Cc1cccc(c1)C(=O)Nc2ccc3[nH]c(O)nc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L04 compound treatment 1.01781558E8 -2.6E7 -0.33 1.05501794E8 -3.49E7 -0.6 -0.6532 -0.9596 1111506 TimTec1_000950 OC(=O)CCc1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L05 compound treatment 1.15991395E8 -1.18E7 -0.15 9.409207E7 -4.63E7 -0.79 -0.6652 -0.825 3209355 TimTec1_000951 FC(F)(F)c1cc(nc2c(Cl)c(nn12)C(=O)N3CCCc4ccccc34)c5cccs5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L06 compound treatment 9.9524101E7 -2.83E7 -0.35 1.0208321E8 -3.83E7 -0.66 -0.7146 -0.9584 1321261 TimTec1_000952 CC(CO)(CO)NS(=O)(=O)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L07 compound treatment 7.1424929E7 -5.64E7 -0.71 8.4731437E7 -5.57E7 -0.95 -1.1738 -0.9892 3209356 TimTec1_000953 CCOC(=O)C1=C(N)n2c(=O)/c(=C\c3ccco3)/sc2=C(C1c4ccco4)C(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L08 compound treatment 5.55191243E8 4.27E8 5.36 5.57024241E8 4.17E8 7.13 8.8341 0.9901 1024363 TimTec1_000954 Nc1ccc(cc1)c2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L09 compound treatment 1.20750921E8 -7050000.0 -0.09 1.26023178E8 -1.44E7 -0.25 -0.2365 -0.9047 1663099 TimTec1_000955 CCN(C(=O)c1cccc(c1)C(=O)N(CC)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L10 compound treatment 1.31749055E8 3940000.0 0.05 9.1743361E7 -4.86E7 -0.83 -0.5539 -0.6639 1061459 TimTec1_000956 CN(c1ccccc1)S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L11 compound treatment 9.6195954E7 -3.16E7 -0.4 1.00941654E8 -3.95E7 -0.68 -0.7579 -0.9678 1730887 TimTec1_000957 CCOC(=O)c1csc(N)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L12 compound treatment 9.7962274E7 -2.98E7 -0.37 1.0571469E8 -3.47E7 -0.59 -0.6845 -0.9753 1709522 TimTec1_000958 O=C(OC1(CCCCC1)C#CCN2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L13 compound treatment 1.06478228E8 -2.13E7 -0.27 9.9825855E7 -4.06E7 -0.69 -0.6802 -0.914 1685514 TimTec1_000959 CCC1(CCCN2CCC3(C4CC1)c5ccc(OC)c(O)c5N4C(=O)C)C23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L14 compound treatment 6.9446758E7 -5.84E7 -0.73 7.2086075E7 -6.83E7 -1.17 -1.3444 -0.9746 1920479 TimTec1_000960 Oc1ccc(/C=N/c2nccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L15 compound treatment 8.384048E7 -4.4E7 -0.55 1.27216938E8 -1.32E7 -0.23 -0.5495 -0.9221 3082723 TimTec1_000961 CC(C)Cn1c(SCC(=O)c2ccc(Cl)cc2)nc3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L16 compound treatment 8.3569459E7 -4.42E7 -0.55 5.5141305E7 -8.53E7 -1.46 -1.4243 -0.9123 3209357 TimTec1_000962 Oc1ccc(/C=N/CC2CCCN3CCCCC23)c(O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L17 compound treatment 8.9139003E7 -3.87E7 -0.49 9.0536796E7 -4.99E7 -0.85 -0.9464 -0.9641 3082725 TimTec1_000963 OC(=O)C(CC(=O)c1ccc(Cl)cc1)NC2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L18 compound treatment 8.2029936E7 -4.58E7 -0.57 7.545297E7 -6.49E7 -1.11 -1.1921 -0.9528 1466736 TimTec1_000964 O=C1N(CCN2CCCCC2)C(=O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L19 compound treatment 9.2517919E7 -3.53E7 -0.44 1.34848511E8 -5540000.0 -0.09 -0.3801 -0.8396 3082726 TimTec1_000965 CC(=O)NCCOc1ccccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L20 compound treatment 1.30032599E8 2230000.0 0.03 9.3406189E7 -4.7E7 -0.8 -0.549 -0.6821 3209478 TimTec1_000966 COC(=O)C1=C(C)N(C)C(=O)NC1c2ccc(OC)c(Br)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L21 compound treatment 1.46965974E8 1.92E7 0.24 8.738706E7 -5.3E7 -0.91 -0.4716 -0.5024 3082728 TimTec1_000967 COc1cccc(c1)c2csc3[nH]cnc(=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L22 compound treatment 7.8473713E7 -4.93E7 -0.62 7.9487139E7 -6.09E7 -1.04 -1.1748 -0.969 1136019 TimTec1_000968 CN(C)c1ccc(cc1)C2NCC(CSc3nc4ccccc4s3)O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L23 mock treatment 1.19101679E8 -8700000.0 -0.11 8.3911832E7 -5.65E7 -0.97 -0.7608 -0.782 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 L24 mock treatment 1.07562973E8 -2.02E7 -0.25 1.64576246E8 2.42E7 0.41 0.1132 0.233 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M01 compound treatment 1.10085307E8 -1.77E7 -0.22 1.24111887E8 -1.63E7 -0.28 -0.3542 -0.9937 1453808 TimTec1_000969 O=C(CC(c1ccccc1)c2ccccc2)NC3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M02 compound treatment 1.18542649E8 -9260000.0 -0.12 1.22343551E8 -1.8E7 -0.31 -0.3006 -0.9108 1706729 TimTec1_000970 Cc1csc(NC(=O)CSc2nc(ccc2C#N)C3(CC4CC5CC(C4)C3)C5)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M03 compound treatment 1.17903969E8 -9900000.0 -0.12 1.28641548E8 -1.18E7 -0.2 -0.2301 -0.9732 1282202 TimTec1_000971 CC1CN(CC(C)O1)S(=O)(=O)c2cccc(c2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M04 compound treatment 1.23462365E8 -4340000.0 -0.05 1.23998405E8 -1.64E7 -0.28 -0.237 -0.8289 3082794 TimTec1_000972 Nc1ccc(Cc2ccc(N)c(C#N)c2)cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M05 compound treatment 1.30418227E8 2610000.0 0.03 1.57860264E8 1.75E7 0.3 0.2346 0.78 3209479 TimTec1_000973 FC(F)(F)c1cc(nc2c(cnn12)C(=O)NCC=C)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M06 compound treatment 1.30642679E8 2840000.0 0.04 1.38561106E8 -1830000.0 -0.03 0.003 0.0635 1356106 TimTec1_000974 CN(C)c1cc(O)c(C(=S)Nc2ccccc2)c(c1)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M07 compound treatment 1.48741636E8 2.09E7 0.26 1.50870857E8 1.05E7 0.18 0.3126 0.9827 1632278 TimTec1_000975 CC(Sc1ncnc2[nH]cnc12)c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M08 compound treatment 1.49737286E8 2.19E7 0.28 1.64418556E8 2.4E7 0.41 0.4854 0.9809 3082797 TimTec1_000976 COc1ccc(/C=N/c2ccccc2C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M09 compound treatment 1.29926902E8 2120000.0 0.03 1.45419553E8 5030000.0 0.09 0.0797 0.8845 3209480 TimTec1_000977 Cc1ccccc1OCCNC(=O)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M10 compound treatment 1.48299185E8 2.05E7 0.26 1.40055813E8 -336000.0 -0.01 0.1777 0.6911 1332157 TimTec1_000978 COc1ccc(NC(=O)c2cccc(C)c2)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M11 compound treatment 1.44417905E8 1.66E7 0.21 1.33300941E8 -7090000.0 -0.12 0.0615 0.2551 3209481 TimTec1_000979 NNC(=O)CCCSc1nc2ccccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M12 compound treatment 1.32051685E8 4250000.0 0.05 9.5072744E7 -4.53E7 -0.78 -0.5109 -0.657 3082799 TimTec1_000980 Cc1ccccc1C(=O)NC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M13 compound treatment 8.5008302E7 -4.28E7 -0.54 7.6592519E7 -6.38E7 -1.09 -1.1519 -0.9465 1494508 TimTec1_000981 Cc1ccc(NC(=O)n2ccnc2)cc1NC(=O)n3ccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M14 compound treatment 1.27596132E8 -208000.0 0.0 1.38925581E8 -1470000.0 -0.03 -0.0196 -0.7766 1306757 TimTec1_000982 CN(C1CCCCC1)S(=O)(=O)c2cc(Cl)ccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M15 compound treatment 1.32138776E8 4330000.0 0.05 1.76980592E8 3.66E7 0.63 0.4813 0.7656 3082802 TimTec1_000983 COc1ccc(/C=N/c2ccc(Br)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M16 compound treatment 1.29816678E8 2010000.0 0.03 1.40917002E8 525000.0 0.01 0.0242 0.9033 1154044 TimTec1_000984 COc1ccc(cc1)S(=O)(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M17 compound treatment 1.57266948E8 2.95E7 0.37 1.02169857E8 -3.82E7 -0.65 -0.2013 -0.2679 3082804 TimTec1_000985 Fc1ccc(/C=N/c2ccc3ccccc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M18 compound treatment 1.23511327E8 -4290000.0 -0.05 1.56001488E8 1.56E7 0.27 0.1509 0.5534 1441763 TimTec1_000986 CCOC(=O)c1ccc(NC(=O)c2ccco2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M19 compound treatment 6.9190225E7 -5.86E7 -0.74 1.248963E8 -1.55E7 -0.27 -0.7075 -0.9051 1358509 TimTec1_000987 CN1CCc2nc3sc(C(=O)C(C)(C)C)c(N)c3cc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M20 compound treatment 1.60675493E8 3.29E7 0.41 1.64672952E8 2.43E7 0.42 0.5855 1.0 1432076 TimTec1_000988 Clc1ccc(NC(=O)CCN2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M21 compound treatment 1.25882162E8 -1920000.0 -0.02 1.5381813E8 1.34E7 0.23 0.1455 0.6295 1556893 TimTec1_000989 CCOC(=O)c1cnn(c1NC(=O)C(C)(C)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M22 compound treatment 1.19307777E8 -8500000.0 -0.11 1.67679749E8 2.73E7 0.47 0.2549 0.5321 3209482 TimTec1_000990 C[C@]1(O)NC(=C(C#N)C(C1[n+]2ccccc2)c3ccc(Cl)cc3)S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M23 mock treatment 1.23499575E8 -4310000.0 -0.05 9.2170521E7 -4.82E7 -0.83 -0.6219 -0.7518 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 M24 mock treatment 1.33780704E8 5980000.0 0.07 1.45745598E8 5350000.0 0.09 0.1178 0.995 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N01 compound treatment 7.5879246E7 -5.19E7 -0.65 1.56956853E8 1.66E7 0.28 -0.2601 -0.3661 1633893 TimTec1_000991 Oc1cccc(c1)C2=NC(=O)c3ccccc3Nc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N02 compound treatment 1.22178605E8 -5630000.0 -0.07 1.5633893E8 1.59E7 0.27 0.1431 0.5076 1083978 TimTec1_000992 CCOC(=O)Nc1ccc(Cl)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N03 compound treatment 8.2436909E7 -4.54E7 -0.57 1.56656564E8 1.63E7 0.28 -0.2056 -0.3244 1379055 TimTec1_000993 CC(=O)OC1C2CCC1C(CC2)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N04 compound treatment 8.3907367E7 -4.39E7 -0.55 1.21011051E8 -1.94E7 -0.33 -0.624 -0.9706 1041245 TimTec1_000994 NNC(=O)CCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N05 compound treatment 6.66265E7 -6.12E7 -0.77 1.02179496E8 -3.82E7 -0.65 -1.0052 -0.9968 1709635 TimTec1_000995 O=C(Nc1ccccc1)OC2C3CCCC2C(CC3)N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N06 compound treatment 1.34387327E8 6580000.0 0.08 1.60456722E8 2.01E7 0.34 0.3013 0.8528 1189065 TimTec1_000996 Cc1ccc(C)c(NS(=O)(=O)c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N07 compound treatment 8.0973211E7 -4.68E7 -0.59 1.03305277E8 -3.71E7 -0.63 -0.8643 -0.9992 1163480 TimTec1_000997 CC(=O)NC1C(=O)N(Cc2ccccc2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N08 compound treatment 1.53213719E8 2.54E7 0.32 1.17094147E8 -2.33E7 -0.4 -0.0566 -0.1109 1111758 TimTec1_000998 Nc1ccc(cc1)c2nc3ccccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N09 compound treatment 1.30881094E8 3080000.0 0.04 8.5726636E7 -5.47E7 -0.94 -0.6344 -0.6774 1140426 TimTec1_000999 CN(Cc1ccccc1)C(=O)c2cccc(c2)C(=O)N(C)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N10 compound treatment 8.6665767E7 -4.11E7 -0.52 1.4994027E8 9550000.0 0.16 -0.2493 -0.4606 1327404 TimTec1_001000 COc1ccc(cc1)C(=O)NC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N11 compound treatment 1.16743942E8 -1.11E7 -0.14 1.39047043E8 -1350000.0 -0.02 -0.1144 -0.8133 3209483 TimTec1_001001 COCC(=O)Nc1cc(Sc2ccccc2)ccc1N=C(NC(=O)C)NC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N12 compound treatment 1.15029527E8 -1.28E7 -0.16 1.56114751E8 1.57E7 0.27 0.077 0.2458 1566798 TimTec1_001002 CCC(CC)(CN(C)C)OC(=O)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N13 compound treatment 9.3407453E7 -3.44E7 -0.43 8.3482469E7 -5.69E7 -0.97 -0.994 -0.9329 3209484 TimTec1_001003 CCCN1CC2(COC)CC[C@H](OC)[C@]3(CC[C@H](COC)[C@@H](O)C[C@@](C)(O)C4(O)[C@@H](OC)[C@@H]32)[C@@H]14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N14 compound treatment 1.29929138E8 2120000.0 0.03 1.42871709E8 2480000.0 0.04 0.0489 0.9749 3082877 TimTec1_001004 Clc1ccc(/C=N/c2ccccn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N15 compound treatment 1.1128746E8 -1.65E7 -0.21 1.1512128E8 -2.53E7 -0.43 -0.4524 -0.9432 3082878 TimTec1_001005 OC(=O)C(CC(=O)c1ccc(cc1)C2CCCCC2)N3CCN(CC3)c4cccc(Cl)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N16 compound treatment 1.21635343E8 -6170000.0 -0.08 9.8996257E7 -4.14E7 -0.71 -0.5558 -0.7797 1649522 TimTec1_001006 O=C1NC(=O)C(CC2CCCN3CCCCC23)C(=O)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N17 compound treatment 1.044309E8 -2.34E7 -0.29 1.03030223E8 -3.74E7 -0.64 -0.6596 -0.9375 3209485 TimTec1_001007 CN(C)/C=N/c1n[nH]c(Nc2ccc(C)c(C)c2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N18 compound treatment 1.16949707E8 -1.09E7 -0.14 9.592422E7 -4.45E7 -0.76 -0.6345 -0.8206 1153859 TimTec1_001008 C[N+]12CCCCC2C(CN3C(=O)c4ccccc4C3=O)CCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N19 compound treatment 1.15304012E8 -1.25E7 -0.16 1.39616966E8 -775000.0 -0.01 -0.1203 -0.7642 3082882 TimTec1_001009 CC(=O)NCCOc1ccc(cc1)C2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N20 compound treatment 2.14606858E8 8.68E7 1.09 2.30845313E8 9.05E7 1.55 1.8648 0.9852 1577050 TimTec1_001010 CCc1ccc(cc1)C2C(=C(C)NC3=C2C(=O)CC(C)(C)C3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N21 compound treatment 1.3658697E8 8780000.0 0.11 1.02587289E8 -3.78E7 -0.65 -0.3797 -0.5784 3082884 TimTec1_001011 COC(=O)c1ccccc1N(C)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N22 compound treatment 1.46102891E8 1.83E7 0.23 1.68132344E8 2.77E7 0.47 0.4981 0.9444 3209486 TimTec1_001012 CN(C)c1ccc(cc1)C2NCC(CSc3nc(cc(c3C#N)C(F)(F)F)c4cccs4)O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N23 mock treatment 1.15598629E8 -1.22E7 -0.15 1.59975081E8 1.96E7 0.34 0.1288 0.3494 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 N24 mock treatment 1.27986113E8 182000.0 0.0 1.46211296E8 5820000.0 0.1 0.072 0.7231 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O01 compound treatment 1.1520757E8 -1.26E7 -0.16 1.16750867E8 -2.36E7 -0.4 -0.3979 -0.9159 1716121 TimTec1_001013 Clc1ccc(NC(=O)CC(c2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O02 compound treatment 1.06417493E8 -2.14E7 -0.27 1.12300637E8 -2.81E7 -0.48 -0.5297 -0.962 3209487 TimTec1_001014 CCOC(=O)C(C)Sc1nc(ccc1C#N)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O03 compound treatment 1.13778686E8 -1.4E7 -0.18 1.24992233E8 -1.54E7 -0.26 -0.3108 -0.9807 1595818 TimTec1_001015 O=S(=O)(NC1CCCCC1)c2cccc(c2)c3nnc(o3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O04 compound treatment 1.17115696E8 -1.07E7 -0.13 1.30481672E8 -9910000.0 -0.17 -0.2148 -0.9932 1004440 TimTec1_001016 COC(=O)c1ccc(cc1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O05 compound treatment 1.22460153E8 -5340000.0 -0.07 1.32950639E8 -7440000.0 -0.13 -0.1375 -0.9551 1455776 TimTec1_001017 OC(=O)CCC(=O)Nc1ccc(Cc2ccncc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O06 compound treatment 1.19796999E8 -8010000.0 -0.1 1.57414368E8 1.7E7 0.29 0.135 0.438 3082886 TimTec1_001018 COC1OC(C)C(OCc2ccccc2)C(O)C1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O07 compound treatment 1.24522844E8 -3280000.0 -0.04 1.30896133E8 -9500000.0 -0.16 -0.1441 -0.8591 1682147 TimTec1_001019 CN(C)C(=O)CSc1nnc(N)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O08 compound treatment 1.22251804E8 -5550000.0 -0.07 1.39117421E8 -1270000.0 -0.02 -0.0647 -0.8862 3082888 TimTec1_001020 OC(=O)c1ccccc1/N=C/c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O09 compound treatment 1.07653751E8 -2.02E7 -0.25 1.1837088E8 -2.2E7 -0.38 -0.4453 -0.9811 1398146 TimTec1_001021 O=C(CC1c2ccccc2Oc3ccccc13)Nc4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O10 compound treatment 1.16102366E8 -1.17E7 -0.15 7.6527977E7 -6.39E7 -1.09 -0.8768 -0.7949 3082890 TimTec1_001022 CCN(c1cccc(C)c1)c2ccccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O11 compound treatment 1.24672168E8 -3130000.0 -0.04 1.19733633E8 -2.07E7 -0.35 -0.2778 -0.7809 3209488 TimTec1_001023 NC1=NN(C(=O)C1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O12 compound treatment 1.22399899E8 -5400000.0 -0.07 9.3151494E7 -4.72E7 -0.81 -0.6198 -0.7637 1608079 TimTec1_001024 COc1ccc(cc1)C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O13 compound treatment 1.15808518E8 -1.2E7 -0.15 9.6160102E7 -4.42E7 -0.76 -0.6418 -0.8314 1340354 TimTec1_001025 CC(=O)Nc1ccc(cc1)S(=O)(=O)CCO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O14 compound treatment 1.20059075E8 -7750000.0 -0.1 1.35297431E8 -5090000.0 -0.09 -0.1304 -0.9985 1049845 TimTec1_001026 O=S(=O)(N1CCN(CC1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O15 compound treatment 1.04308997E8 -2.35E7 -0.29 1.44720758E8 4330000.0 0.07 -0.156 -0.5134 3209489 TimTec1_001027 CC(=O)Nc1ccc(/N=C/c2cccc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O16 compound treatment 1.12164368E8 -1.56E7 -0.2 1.23331832E8 -1.71E7 -0.29 -0.3452 -0.9813 1685172 TimTec1_001028 CCc1ccc(NS(=O)(=O)c2ccc(OC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O17 compound treatment 4.4854657E7 -8.29E7 -1.04 4.9554935E7 -9.08E7 -1.55 -1.8353 -0.9809 1709515 TimTec1_001029 CC(NC(=O)c1sc2nc(C)cc(C)c2c1N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O18 compound treatment 1.43674499E8 1.59E7 0.2 1.2964782E8 -1.07E7 -0.18 0.0107 0.0395 3209490 TimTec1_001030 NC1=C(C#N)C(c2cccc(F)c2)n3c(=O)/c(=C\c4cccc(F)c4)/sc3=C1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O19 compound treatment 1.12773952E8 -1.5E7 -0.19 9.8685214E7 -4.17E7 -0.71 -0.6382 -0.8642 1220431 TimTec1_001031 Cc1ccc(o1)C2C(=C(N)Oc3c2c(=O)oc4ccccc34)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O20 compound treatment 1.15459962E8 -1.23E7 -0.15 1.48488955E8 8100000.0 0.14 -0.0115 -0.0553 3209602 TimTec1_001032 CC1(C)NCCC21C(=O)N(Cc3ccccc3)c4ccccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O21 compound treatment 1.1045556E8 -1.73E7 -0.22 1.25809888E8 -1.46E7 -0.25 -0.3304 -0.9977 1707435 TimTec1_001033 CCN(CC)C(=O)c1c(NC(=O)c2cccs2)sc3CCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O22 compound treatment 9.3390934E7 -3.44E7 -0.43 1.51989483E8 1.16E7 0.2 -0.1649 -0.347 1398816 TimTec1_001034 NC1=C(C#N)C(c2ccoc2)c3c([nH]nc3O1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O23 mock treatment 1.18164486E8 -9640000.0 -0.12 1.38803937E8 -1590000.0 -0.03 -0.1047 -0.845 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 O24 mock treatment 1.2057074E8 -7230000.0 -0.09 1.45999415E8 5610000.0 0.1 0.0037 0.028 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P01 compound treatment 1.18281954E8 -9520000.0 -0.12 1.45059627E8 4670000.0 0.08 -0.028 -0.1947 1265807 TimTec1_001035 O=c1cc(c2ccccc2)n(cn1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P02 compound treatment 9.2325537E7 -3.55E7 -0.45 1.49988007E8 9600000.0 0.16 -0.1986 -0.4185 3209603 TimTec1_001036 CN1C2C(N=C1OCC=C)N(C)C(=O)N(C)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P03 compound treatment 1.17195324E8 -1.06E7 -0.13 1.34366003E8 -6030000.0 -0.1 -0.1671 -0.9921 1404718 TimTec1_001037 COc1cc(ccc1O)C2OCC3C(C)C=C(C)C2C3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P04 compound treatment 1.19470851E8 -8330000.0 -0.1 1.37792488E8 -2600000.0 -0.04 -0.1054 -0.9276 3082971 TimTec1_001038 CN1CN(C(=C1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P05 compound treatment 1.06851009E8 -2.1E7 -0.26 1.23624908E8 -1.68E7 -0.29 -0.3888 -0.999 1591413 TimTec1_001039 CC1C=C(C)C2C(C)C1(COC(=O)Nc3ccccc3)COC2c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P06 compound treatment 1.17093935E8 -1.07E7 -0.13 1.54584471E8 1.42E7 0.24 0.0768 0.2766 1353881 TimTec1_001040 C=CCC1(C2CCCC2)C(=O)NC(=O)NC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P07 compound treatment 9.2310164E7 -3.55E7 -0.45 1.01735331E8 -3.87E7 -0.66 -0.7828 -0.9814 3082974 TimTec1_001041 N(=c/1\[nH]n(c[n+]1c2ccccc2)c3ccccc3)\c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P08 compound treatment 1.27663206E8 -141000.0 0.0 1.32073255E8 -8320000.0 -0.14 -0.1019 -0.7159 1117800 TimTec1_001042 Nc1ccc2oc(nc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P09 compound treatment 1.20099073E8 -7710000.0 -0.1 7.7080069E7 -6.33E7 -1.08 -0.8347 -0.7671 3209604 TimTec1_001043 CC1C2C(O)C3C(N(C)C)C(=C(C(=O)N)C(=O)C3(O)C(=C2Cc4c(O)cccc14)O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P10 compound treatment 1.21207819E8 -6600000.0 -0.08 1.6146515E8 2.11E7 0.36 0.1966 0.5311 1446940 TimTec1_001044 CCOc1ccc(cc1)C(=O)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P11 compound treatment 1.1027611E8 -1.75E7 -0.22 1.35952952E8 -4440000.0 -0.08 -0.2092 -0.8993 3082976 TimTec1_001045 FC(F)(F)c1cccc(/N=C/c2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P12 compound treatment 1.28954557E8 1150000.0 0.01 1.54110937E8 1.37E7 0.23 0.1763 0.7491 3209605 TimTec1_001046 CC[N+](C)(CC)C/C=C\1/COCO1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P13 compound treatment 1.23700649E8 -4100000.0 -0.05 1.11946498E8 -2.84E7 -0.49 -0.3807 -0.7775 1357190 TimTec1_001047 COc1ccc(CC(=O)N(CC#N)CC#N)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P14 compound treatment 1.34502006E8 6700000.0 0.08 1.35699663E8 -4690000.0 -0.08 0.0026 0.0224 3082979 TimTec1_001048 C1OCc2cccc(/C=N/c3nccs3)c2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P15 compound treatment 1.1729814E8 -1.05E7 -0.13 1.43735407E8 3340000.0 0.06 -0.0527 -0.367 3209606 TimTec1_001049 Cc1cc(C)nc(SCc2nc3ccccc3c(=O)n2c4ccc(cc4)C(F)(F)F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P16 compound treatment 1.01885022E8 -2.59E7 -0.33 9.3875731E7 -4.65E7 -0.8 -0.793 -0.9219 2110705 TimTec1_001050 CN(C)c1ccc(/C=N/CC2CCCN3CCCCC23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P17 compound treatment 1.21547794E8 -6260000.0 -0.08 1.41885863E8 1490000.0 0.03 -0.0374 -0.4533 3082982 TimTec1_001051 OC(=O)C(CC(=O)c1ccc(Br)cc1)NCCc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P18 compound treatment 1.28432473E8 628000.0 0.01 1.31318766E8 -9070000.0 -0.16 -0.1043 -0.6704 3209607 TimTec1_001052 OC(=O)c1cc(/C=N/c2ccc(cc2)S(=O)(=O)NC3NC=CS3)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P19 compound treatment 8.7500223E7 -4.03E7 -0.51 7.5835082E7 -6.46E7 -1.11 -1.1389 -0.9372 1482831 TimTec1_001053 CN(c1cccc2cccnc12)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P20 compound treatment 1.28430052E8 625000.0 0.01 1.31351653E8 -9040000.0 -0.15 -0.1039 -0.6704 1207395 TimTec1_001054 CC(C)COC(=O)C1=C(C)N(C)C(=O)NC1c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P21 compound treatment 1.19442775E8 -8360000.0 -0.1 1.26535778E8 -1.39E7 -0.24 -0.2419 -0.9327 3082984 TimTec1_001055 Cn1c(S)nc2sc3CC(CCc3c2c1=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P22 compound treatment 1.00214996E8 -2.76E7 -0.35 1.05592438E8 -3.48E7 -0.6 -0.666 -0.9666 3209608 TimTec1_001056 CCN(CC)C(=S)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P23 mock treatment 1.22330972E8 -5470000.0 -0.07 1.55189218E8 1.48E7 0.25 0.1306 0.4975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2065 P24 mock treatment 1.16792112E8 -1.1E7 -0.14 1.47893299E8 7500000.0 0.13 -0.0069 -0.0365 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A01 compound treatment 1.32879548E8 -2940000.0 -0.04 1.30236626E8 -5100000.0 -0.09 -0.0877 -0.9265 3209609 TimTec1_001057 FC(F)(F)c1cc(NC(=O)C(=S)N2CCCCC2)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A02 compound treatment 1.316528E8 -4160000.0 -0.05 1.46444818E8 1.11E7 0.19 0.0976 0.4946 3082986 TimTec1_001058 CCN1C(=C(C#N)C2(CCNCC2)c3nc(C)oc13)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A03 compound treatment 1.03456265E8 -3.24E7 -0.41 1.08573997E8 -2.68E7 -0.46 -0.6109 -0.9982 3082988 TimTec1_001059 Oc1cccc(/C=C\2/NC(=S)SC2=O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A04 compound treatment 1.42095742E8 6280000.0 0.08 1.53596755E8 1.83E7 0.31 0.2768 0.8584 3209610 TimTec1_001060 CCCc1nc2C(C(=C(N)Nc2o1)C#N)c3cnn(c3C)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A05 compound treatment 1.38813479E8 3000000.0 0.04 1.5678535E8 2.15E7 0.37 0.2863 0.7754 1135930 TimTec1_001061 O=C(NCCN1CCCCC1)Nc2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A06 compound treatment 1.45959905E8 1.01E7 0.13 1.47458677E8 1.21E7 0.21 0.2368 0.9724 1680573 TimTec1_001062 COc1cc(OC)cc(c1)C(C(C#N)C#N)c2nc(C)[nH]c2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A07 compound treatment 1.38865184E8 3050000.0 0.04 1.41673836E8 6340000.0 0.11 0.1038 0.9019 3209611 TimTec1_001063 CCOC(=O)C(N)Cc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A08 compound treatment 1.40640984E8 4820000.0 0.06 9.5720895E7 -3.96E7 -0.68 -0.4367 -0.6414 1656439 TimTec1_001064 CCN(CC)C(=S)CSc1nc(cc(c2ccco2)c1C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A09 compound treatment 1.44653503E8 8840000.0 0.11 9.7130744E7 -3.82E7 -0.65 -0.384 -0.579 1709298 TimTec1_001065 COc1ccc2CCC(CC3(O)C(=O)N(C)c4ccccc43)C(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A10 compound treatment 1.62167434E8 2.64E7 0.33 1.62703581E8 2.74E7 0.47 0.565 0.9854 1586331 TimTec1_001066 CC1=CC(c2ccoc2)c3c(S1)oc(N)c(C#N)c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A11 compound treatment 1.04901548E8 -3.09E7 -0.39 1.02293499E8 -3.3E7 -0.57 -0.6741 -0.9831 3083064 TimTec1_001067 Fc1ccc(CSC(=C(C#N)C#N)Nc2ccc(Br)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A12 compound treatment 1.60585049E8 2.48E7 0.31 1.75489707E8 4.02E7 0.69 0.7058 0.9356 3209612 TimTec1_001068 CCCN1CC=C2C(C#N)(C#N)C(=C(C)[C@H](c3ccc(cc3)C(=O)OC)[C@@]2(C)C1)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A13 compound treatment 1.16764713E8 -1.91E7 -0.24 1.28835426E8 -6500000.0 -0.11 -0.2476 -0.9394 1679027 TimTec1_001069 CC(C)Oc1ccc(cc1)C2C(=C(N)N(c3oc(C)nc23)c4ccccc4)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A14 compound treatment 1.39524211E8 3710000.0 0.05 1.6342611E8 2.81E7 0.48 0.3729 0.7719 3209613 TimTec1_001070 CC(C)(C)C1CC=C2[C@H](C1)[C@H](C(=C(N)C2(C#N)C#N)C#N)c3ccsc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A15 compound treatment 1.05899049E8 -2.99E7 -0.38 1.45534723E8 1.02E7 0.17 -0.1419 -0.3428 3209614 TimTec1_001071 CN1C2CCC1[C@@H]3[C@H](C(=C(N)C(C#N)(C#N)C3=C2)C#N)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A16 compound treatment 1.42654532E8 6840000.0 0.09 1.43545522E8 8210000.0 0.14 0.1601 0.9719 1128630 TimTec1_001072 COc1cc(OC)cc(c1)C2SC(=C(C#N)C(=C2C#N)N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A17 compound treatment 1.39913195E8 4100000.0 0.05 1.40920916E8 5590000.0 0.1 0.104 0.9575 3083068 TimTec1_001073 COC(=O)C1=C(N)OC2=C(CCCC2=O)C1c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A18 compound treatment 1.53436033E8 1.76E7 0.22 1.52593364E8 1.73E7 0.3 0.3652 0.9898 3209615 TimTec1_001074 Clc1cccc(c1)C(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A19 compound treatment 1.61058975E8 2.52E7 0.32 1.46556679E8 1.12E7 0.19 0.3598 0.9713 1165075 TimTec1_001075 CCOC(=O)C1=C(S)N(C#N)C(=O)C(C#N)C21CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A20 compound treatment 1.38523162E8 2710000.0 0.03 1.39734246E8 4400000.0 0.08 0.0773 0.9352 3083071 TimTec1_001076 CC(NC(=O)c1ccc(cc1)C(C)(C)C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A21 compound treatment 1.30231311E8 -5590000.0 -0.07 1.21664088E8 -1.37E7 -0.23 -0.215 -0.8802 1594569 TimTec1_001077 CCOC(=O)C1=C(N)OC(=C(C#N)C1c2ccccc2)c3cccc(OC)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A22 compound treatment 9.6546051E7 -3.93E7 -0.49 1.31951337E8 -3380000.0 -0.06 -0.3893 -0.7848 1190176 TimTec1_001078 CCOC(=O)C1CCCn2c1nc3sc4CCCCc4c3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A23 mock treatment 1.42919916E8 7100000.0 0.09 1.49481487E8 1.41E7 0.24 0.2343 0.9078 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 A24 mock treatment 1.35564864E8 -252000.0 0.0 1.55900592E8 2.06E7 0.35 0.2467 0.7007 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B01 compound treatment 1.17810833E8 -1.8E7 -0.23 1.51942508E8 1.66E7 0.28 0.0413 0.1138 3209616 TimTec1_001079 O=c1oc(nc2scc(c3ccccc3)c12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B02 compound treatment 1.02824304E8 -3.3E7 -0.41 9.3892051E7 -4.14E7 -0.71 -0.7943 -0.9671 1252791 TimTec1_001080 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3N(C2c4ccco4)C(=S)Nc5cccc(Cl)c5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B03 compound treatment 9.7243073E7 -3.86E7 -0.48 9.5013582E7 -4.03E7 -0.69 -0.8302 -0.9849 3083074 TimTec1_001081 CCC(C)NC(=O)CSc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B04 compound treatment 9.9237721E7 -3.66E7 -0.46 9.6842666E7 -3.85E7 -0.66 -0.7904 -0.9844 3083076 TimTec1_001082 O=C(CCCCn1cnc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B05 compound treatment 1.1807629E8 -1.77E7 -0.22 9.2015759E7 -4.33E7 -0.74 -0.6817 -0.8805 1133090 TimTec1_001083 C1CC2=C(Nc3ncnn3C2c4ccccc4)c5ccccc5C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B06 compound treatment 1.15383643E8 -2.04E7 -0.26 9.0201921E7 -4.51E7 -0.77 -0.7275 -0.8938 1354657 TimTec1_001084 CC1CN(C)C(C(C)C21NC(=O)NC2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B07 compound treatment 9.7550821E7 -3.83E7 -0.48 9.4937568E7 -4.04E7 -0.69 -0.8284 -0.9841 3083078 TimTec1_001085 Clc1cnn(Cc2ccccc2)c(=S)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B08 compound treatment 1.79806756E8 4.4E7 0.55 8.6055383E7 -4.93E7 -0.84 -0.2063 -0.2046 3209617 TimTec1_001086 OC(=O)[C@H]1NC(=O)C1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B09 compound treatment 9.7659334E7 -3.82E7 -0.48 1.33928836E8 -1400000.0 -0.02 -0.3555 -0.7417 1612069 TimTec1_001087 Nc1sc2CCCc2c1C(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B10 compound treatment 1.09702003E8 -2.61E7 -0.33 1.38774742E8 3440000.0 0.06 -0.19 -0.5708 3083081 TimTec1_001088 CC/1=NN(C(=O)\C1=C\2/C(=O)Nc3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B11 compound treatment 4.9433684E7 -8.64E7 -1.08 3.6076048E7 -9.93E7 -1.7 -1.9677 -0.9764 1674088 TimTec1_001089 Nn1c(nc2ccccc2c1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B12 compound treatment 1.55211567E8 1.94E7 0.24 1.27147529E8 -8180000.0 -0.14 0.073 0.2599 1517968 TimTec1_001090 O=C(N1CCc2ccccc12)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B13 compound treatment 1.51019595E8 1.52E7 0.19 9.5200485E7 -4.01E7 -0.69 -0.3509 -0.4922 1537974 TimTec1_001091 Nc1sc2CCCCCc2c1C(=O)Nc3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B14 compound treatment 1.0814191E8 -2.77E7 -0.35 1.30705176E8 -4630000.0 -0.08 -0.3015 -0.8467 3083084 TimTec1_001092 CCCNC(=O)Cn1nc(cc1C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B15 compound treatment 1.79872778E8 4.41E7 0.55 9.1902079E7 -4.34E7 -0.74 -0.1349 -0.1456 3209740 TimTec1_001093 Cc1cc(Br)c(NC(=O)C2C(C)(C)C2(C)C)c(Br)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B16 compound treatment 1.36419247E8 603000.0 0.01 8.6499268E7 -4.88E7 -0.84 -0.5857 -0.7007 1410434 TimTec1_001094 CC(C)(C)c1nc2ccccc2c(=O)n1c3ccc(F)cc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B17 compound treatment 1.02390355E8 -3.34E7 -0.42 1.43428796E8 8100000.0 0.14 -0.1985 -0.4495 3083156 TimTec1_001095 CCOC(=O)c1ccc(/N=C/c2ccc(CC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B18 compound treatment 1.05122027E8 -3.07E7 -0.39 8.7218743E7 -4.81E7 -0.82 -0.8547 -0.94 1578203 TimTec1_001096 Fc1ccc(NC(=O)CCC(=O)N(Cc2ccccc2)Cc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B19 compound treatment 9.9147662E7 -3.67E7 -0.46 1.42671569E8 7340000.0 0.13 -0.2364 -0.4958 3083160 TimTec1_001097 CC(=O)Nc1nonc1/N=C\c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B20 compound treatment 1.65570078E8 2.98E7 0.37 8.2777948E7 -5.26E7 -0.9 -0.3722 -0.3822 1344731 TimTec1_001098 Fc1ccc(CNC(=O)c2ccccc2C(=O)Cc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B21 compound treatment 1.06790721E8 -2.9E7 -0.36 1.00146702E8 -3.52E7 -0.6 -0.6834 -0.9709 1376655 TimTec1_001099 COc1cc(SC)ccc1C(=O)NC2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B22 compound treatment 1.49418618E8 1.36E7 0.17 1.44420143E8 9090000.0 0.16 0.2307 0.9989 3209741 TimTec1_001100 Oc1ccc(cc1)C(=O)N2Cc3ccccc3N=C2S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B23 mock treatment 1.48511933E8 1.27E7 0.16 9.836307E7 -3.7E7 -0.63 -0.3349 -0.5132 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 B24 mock treatment 1.56182062E8 2.04E7 0.26 1.49583641E8 1.43E7 0.24 0.3531 0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C01 compound treatment 1.41949829E8 6130000.0 0.08 1.42606805E8 7270000.0 0.12 0.1425 0.9732 3209742 TimTec1_001101 Cc1cccc(NC(=O)CSc2nsc(SCC(=O)Nc3cccc(C)c3)c2C#N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C02 compound treatment 1.27138137E8 -8680000.0 -0.11 1.32828112E8 -2500000.0 -0.04 -0.1073 -0.917 3083163 TimTec1_001102 CCN(CC)c1cc(nc(SCC(=O)c2cccs2)c1C#N)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C03 compound treatment 1.53239829E8 1.74E7 0.22 1.41559812E8 6230000.0 0.11 0.2299 0.9455 3083164 TimTec1_001103 N=c1sc2ccccc2n1C(=O)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C04 compound treatment 1.38833649E8 3020000.0 0.04 1.45403339E8 1.01E7 0.17 0.1487 0.8423 3209743 TimTec1_001104 COc1cccc(c1)[C@@H]2[C@H](N3C=Cc4ccccc4[C@@H]3C2(C#N)C#N)c5ccc(OC)c(F)c5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C05 compound treatment 1.48454243E8 1.26E7 0.16 1.59906708E8 2.46E7 0.42 0.4096 0.911 1213390 TimTec1_001105 O=C(CSC1OC2C=CC=CC2=N1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C06 compound treatment 1.54315951E8 1.85E7 0.23 1.46680369E8 1.13E7 0.19 0.3015 0.9961 3209744 TimTec1_001106 CC1CC(=O)C2=C(O1)OC(=C(C#N)C2c3ccccc3C(F)(F)F)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C07 compound treatment 2.87528232E8 1.52E8 1.9 2.6836274E8 1.33E8 2.28 2.956 0.996 1713226 TimTec1_001107 COc1cc2ccc(=O)oc2c(OC3OC(CO)C(O)C(O)C3O)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C08 compound treatment 3.4793328E7 -1.01E8 -1.27 2.8336843E7 -1.07E8 -1.83 -2.1912 -0.9838 3083167 TimTec1_001108 Cc1ccc(CSc2nc(ccc2C#N)C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C09 compound treatment 1.59170353E8 2.34E7 0.29 9.9408332E7 -3.59E7 -0.61 -0.2277 -0.3342 3209745 TimTec1_001109 COc1cc(cc(OC)c1OC)c2c(C#N)c(SCC#N)nc(N)c2C(=O)OC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C10 compound treatment 2.13489384E8 7.77E7 0.97 1.92276447E8 5.69E7 0.97 1.3782 1.0 3083169 TimTec1_001110 CCc1ccc(cc1)[C@@H]2[C@H]3CN(CC=C3C(C#N)(C#N)C(=C2C#N)N)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C11 compound treatment 1.20951713E8 -1.49E7 -0.19 1.31652834E8 -3680000.0 -0.06 -0.1764 -0.8962 3209746 TimTec1_001111 Fc1cccc(CSC(=C(C#N)C#N)Nc2ccccc2Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C12 compound treatment 1.32867909E8 -2950000.0 -0.04 1.14804307E8 -2.05E7 -0.35 -0.2746 -0.7772 3209747 TimTec1_001112 COC(=O)C1=C(N)OC2=C(C1c3ccc(cc3)C(=O)OC)C(=O)CC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C13 compound treatment 1.33005723E8 -2810000.0 -0.04 1.27919194E8 -7410000.0 -0.13 -0.1147 -0.8706 1123898 TimTec1_001113 COC(=O)[C@@]1(C#N)C([C@@H](C#N)N2[C@@H]1C=Cc3ccccc23)c4cc(OC)cc(OC)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C14 compound treatment 1.46328801E8 1.05E7 0.13 1.21663141E8 -1.37E7 -0.23 -0.0722 -0.2688 1317642 TimTec1_001114 COc1ccc(cc1)c2cc(SCCN3CCOCC3)c(C#N)c(n2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C15 compound treatment 1.54269229E8 1.85E7 0.23 1.32314328E8 -3020000.0 -0.05 0.1271 0.5361 3083174 TimTec1_001115 CCOC(=O)C1=C(N)SC(=C(C#N)C1c2ccco2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C16 compound treatment 1.51533709E8 1.57E7 0.2 1.15489031E8 -1.98E7 -0.34 -0.1008 -0.2566 1197248 TimTec1_001116 Cc1cc2CC(=C(C#N)C(c3cccc(COc4ccccc4Cl)c3)c2c(=O)o1)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C17 compound treatment 1.287442E8 -7070000.0 -0.09 1.38043113E8 2710000.0 0.05 -0.0299 -0.2989 3209748 TimTec1_001117 CCOC(=O)C1=C(OC(=C(C#N)C1c2ccc(cc2)c3ccccc3)N)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C18 compound treatment 1.41149088E8 5330000.0 0.07 1.54158346E8 1.88E7 0.32 0.2752 0.8361 3083176 TimTec1_001118 CC1CCN(CC1)C(=O)c2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C19 compound treatment 1.65087771E8 2.93E7 0.37 1.4350746E8 8170000.0 0.14 0.3586 0.9126 3209749 TimTec1_001119 CC1=C(C#N)C(C2=C(CC(CC2=O)c3ccc(Br)cc3)O1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C20 compound treatment 1.44687255E8 8870000.0 0.11 1.29601264E8 -5730000.0 -0.1 0.0093 0.0628 3083178 TimTec1_001120 CC(=O)NC(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C21 compound treatment 1.44233158E8 8420000.0 0.11 1.10976387E8 -2.44E7 -0.42 -0.2202 -0.5119 3209750 TimTec1_001121 COc1ccc(cc1OC)C(=O)COC2=C(C#N)C3(CCCC3)C(C#N)C(=S)N2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C22 compound treatment 1.27439478E8 -8380000.0 -0.11 1.37569008E8 2240000.0 0.04 -0.0472 -0.4223 3083180 TimTec1_001122 C1CCc2c(C1)sc3ncnc(Sc4ccccc4)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C23 mock treatment 1.33040338E8 -2780000.0 -0.03 1.50345907E8 1.5E7 0.26 0.1571 0.6057 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 C24 mock treatment 1.47666499E8 1.18E7 0.15 1.44155775E8 8820000.0 0.15 0.2119 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D01 compound treatment 1.74893522E8 3.91E7 0.49 5.8936324E7 -7.64E7 -1.31 -0.5781 -0.4139 1699716 TimTec1_001123 CCc1nc2sc(C)c(C)c2c(=O)n1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D02 compound treatment 1.46914484E8 1.11E7 0.14 5.41641E7 -8.12E7 -1.39 -0.884 -0.6331 3209751 TimTec1_001124 CC1(C)C(C(=O)NN2C(=O)c3ccccc3C2=O)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D03 compound treatment 1.63784509E8 2.8E7 0.35 5.3477427E7 -8.19E7 -1.4 -0.7427 -0.5142 3082090 TimTec1_001125 CC(C)(C)NC(=O)CSc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D04 compound treatment 1.52473821E8 1.67E7 0.21 6.781495E7 -6.75E7 -1.16 -0.6695 -0.57 1162107 TimTec1_001126 CC(C)N1CCC2(CC1)C(=C(O)NC3=C2C(=O)CC(C)(C)C3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D05 compound treatment 1.74342249E8 3.85E7 0.48 6.5838015E7 -6.95E7 -1.19 -0.4994 -0.389 3209752 TimTec1_001127 COc1ccc(cc1)N2Cc3ccccc3C4(CCOCC4)C2=N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D06 compound treatment 1.30319764E8 -5500000.0 -0.07 7.1210282E7 -6.41E7 -1.1 -0.8249 -0.75 3209753 TimTec1_001128 COc1ccc(/N=C(\C)/c2c([nH]n(c3nc4ccccc4s3)c2=O)C(F)(F)F)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D07 compound treatment 1.59530483E8 2.37E7 0.3 6.0102522E7 -7.52E7 -1.29 -0.7003 -0.5298 1727579 TimTec1_001129 Clc1c(NCC2CCCO2)cnn(Cc3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D08 compound treatment 1.72649353E8 3.68E7 0.46 7.6534207E7 -5.88E7 -1.01 -0.385 -0.3476 3082095 TimTec1_001130 Cc1ccc(cc1)C2=NNC(=S)C3=CNc4ccccc4N23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D09 compound treatment 1.60093324E8 2.43E7 0.3 5.7221292E7 -7.81E7 -1.34 -0.7301 -0.5324 1199669 TimTec1_001131 CCOc1ccc(NC(=O)c2c(N)sc3CCCc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D10 compound treatment 1.74139382E8 3.83E7 0.48 5.6966504E7 -7.84E7 -1.34 -0.6086 -0.4271 1714748 TimTec1_001132 NC(=O)CSc1nc2CC3=C(CCC3)c2c(=O)n1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D11 compound treatment 1.76664744E8 4.08E7 0.51 1.06934728E8 -2.84E7 -0.49 0.0186 0.0263 1348333 TimTec1_001133 O=c1oc(nc2ccccc12)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D12 compound treatment 1.52182478E8 1.64E7 0.21 8.7525636E7 -4.78E7 -0.82 -0.4335 -0.5138 1118692 TimTec1_001134 O=C(N1CCCc2ccccc12)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D13 compound treatment 1.66175903E8 3.04E7 0.38 1.01504224E8 -3.38E7 -0.58 -0.1402 -0.2022 1352264 TimTec1_001135 CN(C)C(=O)c1c(NC(=O)c2ccc(C)cc2)sc3CCCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D14 compound treatment 1.57906316E8 2.21E7 0.28 8.06112E7 -5.47E7 -0.94 -0.4664 -0.4775 3209754 TimTec1_001136 CCc1c(C)sc(NC(=O)/C=C/c2ccc(F)cc2)c1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D15 compound treatment 1.79428583E8 4.36E7 0.55 9.1095633E7 -4.42E7 -0.76 -0.1486 -0.1591 3082099 TimTec1_001137 C=CC[n+]1ccc2ccccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D16 compound treatment 1.81654801E8 4.58E7 0.58 1.03327551E8 -3.2E7 -0.55 0.0192 0.0242 3209755 TimTec1_001138 FC(F)(F)c1cccc(c1)C(=O)Oc2ccc(cc2)C3SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D17 compound treatment 1.60866633E8 2.51E7 0.31 1.02065104E8 -3.33E7 -0.57 -0.1805 -0.2775 3082101 TimTec1_001139 CCOc1ccc2ccccc2c1/C=N/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D18 compound treatment 1.43256511E8 7440000.0 0.09 8.7999007E7 -4.73E7 -0.81 -0.5069 -0.6215 1260565 TimTec1_001140 Clc1ccc(NC(=O)CN2CCCc3ccccc23)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D19 compound treatment 1.55642113E8 1.98E7 0.25 1.04788656E8 -3.05E7 -0.52 -0.1939 -0.3348 1408681 TimTec1_001141 NNC(=O)c1cccc(Cn2cccn2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D20 compound treatment 3.6152413E7 -9.97E7 -1.25 5.6477492E7 -7.89E7 -1.35 -1.8385 -0.9993 3209756 TimTec1_001142 CC(C)Cn1c(=O)c2ccccc2[nH]c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D21 compound treatment 1.48314466E8 1.25E7 0.16 1.14341382E8 -2.1E7 -0.36 -0.1432 -0.3653 1521586 TimTec1_001143 Cc1ccccc1OCc2nnc(SCC(=O)N)n2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D22 compound treatment 1.29989001E8 -5830000.0 -0.07 9.4624004E7 -4.07E7 -0.7 -0.5444 -0.777 3209757 TimTec1_001144 COc1ccc(/C=N/C2=NNC(=O)C(CC(=O)O)S2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D23 mock treatment 1.43875306E8 8060000.0 0.1 8.3626049E7 -5.17E7 -0.89 -0.5544 -0.6223 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 D24 mock treatment 1.46623706E8 1.08E7 0.14 9.2680373E7 -4.27E7 -0.73 -0.4204 -0.5661 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E01 compound treatment 1.16500352E8 -1.93E7 -0.24 1.09109445E8 -2.62E7 -0.45 -0.4888 -0.9581 1632993 TimTec1_001145 NC(=O)c1cnn2c(N)c(C#N)cnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E02 compound treatment 1.15649022E8 -2.02E7 -0.25 1.10583922E8 -2.47E7 -0.42 -0.4785 -0.9696 1454243 TimTec1_001146 CC(C)OC(=O)C1=C(C)SC(=C(C#N)C1c2ccc(cc2)C(C)C)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E03 compound treatment 1.12480273E8 -2.33E7 -0.29 1.05528067E8 -2.98E7 -0.51 -0.5678 -0.9652 3082105 TimTec1_001147 COc1cc(/C=N\C2=NN(CC2)c3ccccc3)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E04 compound treatment 1.23852842E8 -1.2E7 -0.15 1.13917022E8 -2.14E7 -0.37 -0.3653 -0.9223 3209876 TimTec1_001148 C[C@@H]1[C@H](N2C=Cc3ccccc3[C@@H]2C1(C#N)C#N)c4ccc(F)c(Br)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E05 compound treatment 1.36887735E8 1070000.0 0.01 8.9637838E7 -4.57E7 -0.78 -0.5436 -0.6949 1448274 TimTec1_001149 Cc1ccc2cccc(SC(=O)NCC3CCCO3)c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E06 compound treatment 1.27738067E8 -8080000.0 -0.1 8.6866548E7 -4.85E7 -0.83 -0.6583 -0.7876 3082108 TimTec1_001150 NC1=C(C#N)C(C2=C(O1)C(=O)CCC2)c3ccccc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E07 compound treatment 1.28354406E8 -7460000.0 -0.09 1.27466053E8 -7870000.0 -0.13 -0.1614 -0.9842 1046360 TimTec1_001151 CC(=O)OCC1OC(C(OC(=O)C)C1OC(=O)C)n2ccc(=O)[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E08 compound treatment 1.14757235E8 -2.11E7 -0.26 7.6871034E7 -5.85E7 -1.0 -0.8944 -0.8642 1129068 TimTec1_001152 CN1CCc2c(nc(OCc3ccccc3Br)c(C#N)c2C1)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E09 compound treatment 1.25702597E8 -1.01E7 -0.13 1.22850414E8 -1.25E7 -0.21 -0.2408 -0.969 3082110 TimTec1_001153 CSc1nc(SCC(=O)c2ccc3OCOc3c2)nc(N)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E10 compound treatment 1.1805853E8 -1.78E7 -0.22 9.5730995E7 -3.96E7 -0.68 -0.6369 -0.8925 1730487 TimTec1_001154 Cc1nc(C(=O)N)c(NCC=C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E11 compound treatment 1.17786034E8 -1.8E7 -0.23 1.14611071E8 -2.07E7 -0.35 -0.4108 -0.9764 1334043 TimTec1_001155 COc1cc2CCN(Cc2cc1OC)C(=O)Cn3c(C)cc(C)c(C#N)c3=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E12 compound treatment 8.9851917E7 -4.6E7 -0.58 1.06484132E8 -2.88E7 -0.49 -0.7569 -0.997 1513685 TimTec1_001156 O=C(c1ccccc1)[C@@]2(C[C@@H](C#N)N3[C@@H]2C=Cc4ccccc34)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E13 compound treatment 1.07477033E8 -2.83E7 -0.36 1.07669433E8 -2.77E7 -0.47 -0.5862 -0.99 1696559 TimTec1_001157 CCN(CC)c1c(C#N)c(SCC(=O)c2cccs2)cc3CCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E14 compound treatment 1.29521089E8 -6300000.0 -0.08 1.29869518E8 -5460000.0 -0.09 -0.122 -0.9965 3209877 TimTec1_001158 CCOC(=O)N1CC=C2C(C1)C(C(=C(N)C2(C#N)C#N)C#N)c3cccc(c3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E15 compound treatment 2.479458E7 -1.11E8 -1.39 2.6633999E7 -1.09E8 -1.86 -2.3005 -0.9898 1628055 TimTec1_001159 OC(=O)c1ccc(cc1)c2cc(c3cccs3)c(C#N)c(SCc4cccs4)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E16 compound treatment 1.23627362E8 -1.22E7 -0.15 1.32652617E8 -2680000.0 -0.05 -0.1406 -0.8805 1516512 TimTec1_001160 CC1=C(C(C(=C(S)S1)C#N)c2ccc[nH]2)C(=O)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E17 compound treatment 9.5547925E7 -4.03E7 -0.51 8.8740504E7 -4.66E7 -0.8 -0.9212 -0.9757 1382001 TimTec1_001161 COc1cc(OC)cc(c1)C2C(=C(N)Nc3oc(C)nc23)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E18 compound treatment 1.00556091E8 -3.53E7 -0.44 1.20813055E8 -1.45E7 -0.25 -0.4885 -0.9628 3082493 TimTec1_001162 CC(C)(C)c1ccc(cc1)C(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E19 compound treatment 1.17398385E8 -1.84E7 -0.23 1.49523862E8 1.42E7 0.24 0.0084 0.0251 3082494 TimTec1_001163 FC(F)(F)c1cc(c2cccs2)c(C#N)c(S)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E20 compound treatment 1.34254336E8 -1560000.0 -0.02 1.25875938E8 -9460000.0 -0.16 -0.1283 -0.787 3209878 TimTec1_001164 CC1(C)C(C(=O)Nc2ccccc2C(F)(F)F)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E21 compound treatment 1.18808374E8 -1.7E7 -0.21 8.0349443E7 -5.5E7 -0.94 -0.8164 -0.8459 3209879 TimTec1_001165 CC(C)N1C/C(=C\c2ccccc2)/C(=O)\C(=C/c3ccccc3)\C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E22 compound treatment 1.14595041E8 -2.12E7 -0.27 1.18282426E8 -1.71E7 -0.29 -0.3946 -0.9989 1473801 TimTec1_001166 CCOC(=O)c1c(N)sc2c(OCC)c(Br)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E23 mock treatment 1.05025122E8 -3.08E7 -0.39 9.4814431E7 -4.05E7 -0.69 -0.7636 -0.9618 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 E24 mock treatment 1.30437725E8 -5380000.0 -0.07 1.34582665E8 -750000.0 -0.01 -0.0568 -0.8268 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F01 compound treatment 7.2772083E7 -6.3E7 -0.79 1.16857094E8 -1.85E7 -0.32 -0.7829 -0.9191 1148234 TimTec1_001167 Cc1sc(NC(=O)c2ccccc2)c(C(=O)N3CCCCC3)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F02 compound treatment 8.035509E7 -5.55E7 -0.7 7.7218021E7 -5.81E7 -0.99 -1.1954 -0.9847 3082495 TimTec1_001168 NCc1c[nH]nc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F03 compound treatment 8.4622702E7 -5.12E7 -0.64 1.37066447E8 1730000.0 0.03 -0.4331 -0.6737 3082496 TimTec1_001169 CCCCC(=O)c1ccc(C)[nH]c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F04 compound treatment 9.2128121E7 -4.37E7 -0.55 1.46489852E8 1.12E7 0.19 -0.2525 -0.435 3209880 TimTec1_001170 FC(F)(F)c1cc([nH]c(=S)c1C#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F05 compound treatment 8.1976338E7 -5.38E7 -0.68 9.1289587E7 -4.4E7 -0.75 -1.0107 -0.9985 1552345 TimTec1_001171 OC1CS(=O)(=O)CC1NCc2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F06 compound treatment 9.1117013E7 -4.47E7 -0.56 1.0543175E8 -2.99E7 -0.51 -0.7584 -0.999 3209881 TimTec1_001172 Cn1ncc(Br)c1c2nc3ccccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F07 compound treatment 1.29654594E8 -6160000.0 -0.08 8.7275983E7 -4.81E7 -0.82 -0.6363 -0.7702 1231705 TimTec1_001173 Clc1c(NCCc2ccccc2)cnn(c3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F08 compound treatment 1.32366926E8 -3450000.0 -0.04 8.2609841E7 -5.27E7 -0.9 -0.6688 -0.7402 3082497 TimTec1_001174 COc1ccc(cc1)C2=NNC(=S)C3=CNc4ccccc4N23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F09 compound treatment 1.14671546E8 -2.11E7 -0.27 8.1892001E7 -5.34E7 -0.91 -0.8344 -0.8761 1268647 TimTec1_001175 O=C(Nc1ccccc1)c2c(NC(=O)c3ccccc3)sc4CCCCc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F10 compound treatment 1.07923731E8 -2.79E7 -0.35 9.8357158E7 -3.7E7 -0.63 -0.695 -0.9609 1547144 TimTec1_001176 CC(NC(=O)CSc1nc2CC3=C(CCCC3)c2c(=O)n1C)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F11 compound treatment 7.256612E7 -6.33E7 -0.79 1.15145387E8 -2.02E7 -0.35 -0.8054 -0.9306 1204419 TimTec1_001177 CC1CCc2c(C(=O)Nc3ccc(Cl)cc3)c(N)sc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F12 compound treatment 9.302919E7 -4.28E7 -0.54 1.05682277E8 -2.97E7 -0.51 -0.7384 -0.9996 1256297 TimTec1_001178 C(Cc1ccco1)C2NCCn3cccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F13 compound treatment 1.17877623E8 -1.79E7 -0.23 6.7542869E7 -6.78E7 -1.16 -0.9797 -0.8288 1201070 TimTec1_001179 CCOC(=O)c1c(NC(=O)C)sc2CCCCCc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F14 compound treatment 1.2613528E8 -9680000.0 -0.12 7.2818819E7 -6.25E7 -1.07 -0.8426 -0.7823 1590373 TimTec1_001180 CC(NC(=O)CC(c1ccccc1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F15 compound treatment 1.10402165E8 -2.54E7 -0.32 8.9037062E7 -4.63E7 -0.79 -0.7858 -0.9199 1021946 TimTec1_001181 OC(=O)C1CCCN1C(=O)OCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F16 compound treatment 7.8870485E7 -5.69E7 -0.71 9.1666367E7 -4.37E7 -0.75 -1.0337 -0.9997 3209882 TimTec1_001182 CCOc1ccc(cc1)N2C(=O)CCC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F17 compound treatment 1.16052338E8 -1.98E7 -0.25 8.450766E7 -5.08E7 -0.87 -0.7905 -0.8738 3209883 TimTec1_001183 CCn1c2C(=O)CCCc2c3cc(Br)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F18 compound treatment 8.409152E7 -5.17E7 -0.65 8.1854177E7 -5.35E7 -0.92 -1.1061 -0.9858 1674582 TimTec1_001184 OCCN(CC(=O)Nc1ccc(F)cc1)C(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F19 compound treatment 9.1319776E7 -4.45E7 -0.56 1.35405827E8 73300.0 0.0 -0.3938 -0.7055 1384058 TimTec1_001185 Cc1ccc2oc3nc(N)c(cc3c(=O)c2c1)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F20 compound treatment 1.01247447E8 -3.46E7 -0.43 1.05438206E8 -2.99E7 -0.51 -0.6685 -0.9966 1143739 TimTec1_001186 CC(C)Cn1c(SCC(=O)Nc2ccc(F)cc2F)nc3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F21 compound treatment 8.6955993E7 -4.89E7 -0.61 8.5983215E7 -4.93E7 -0.84 -1.0307 -0.9876 1602491 TimTec1_001187 COC(=O)c1ccc(NC(=O)CSC(=S)N2CCOCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F22 compound treatment 8.935855E7 -4.65E7 -0.58 1.3514108E8 -191000.0 0.0 -0.4144 -0.7111 3082498 TimTec1_001188 Brc1ccc(cc1)C(=O)CN2CCCC2=N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F23 mock treatment 1.19003267E8 -1.68E7 -0.21 1.21718542E8 -1.36E7 -0.23 -0.3139 -0.9988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 F24 mock treatment 1.11465956E8 -2.44E7 -0.31 1.3656108E8 1230000.0 0.02 -0.2011 -0.6569 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G01 compound treatment 1.58245549E8 2.24E7 0.28 1.41816412E8 6480000.0 0.11 0.2774 0.9173 1278450 TimTec1_001189 CCOC(=O)c1cnn2c(N)c(C#N)cnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G02 compound treatment 1.55964785E8 2.01E7 0.25 1.42799574E8 7470000.0 0.13 0.2691 0.9501 1287956 TimTec1_001190 NC1=C(C#N)C(c2ccccc2Cl)c3c(S1)oc(cc3=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G03 compound treatment 1.65165875E8 2.93E7 0.37 1.45318806E8 9990000.0 0.17 0.3812 0.9391 1053983 TimTec1_001191 COC(=O)C1CNc2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G04 compound treatment 1.58371878E8 2.26E7 0.28 1.62056789E8 2.67E7 0.46 0.5235 0.9733 3082499 TimTec1_001192 COC(=O)C1=C(N)OC(=C(C#N)C1c2ccncc2)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G05 compound treatment 1.67647682E8 3.18E7 0.4 1.47670665E8 1.23E7 0.21 0.4317 0.9557 3209884 TimTec1_001193 CC1=CC(C)(C)CC(=S)N1c2cccc(F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G06 compound treatment 1.00811744E8 -3.5E7 -0.44 8.7211016E7 -4.81E7 -0.82 -0.893 -0.9566 3082500 TimTec1_001194 NC1=C(C#N)C(=C(C#N)C(S1)c2cccs2)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G07 compound treatment 1.74433488E8 3.86E7 0.48 1.53743208E8 1.84E7 0.32 0.5654 0.9783 3209885 TimTec1_001195 O=C1CNC(=S)N1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G08 compound treatment 1.64324438E8 2.85E7 0.36 1.1834332E8 -1.7E7 -0.29 0.0472 0.1025 1277858 TimTec1_001196 Cc1c2cc(sc2nc3c(O)cc(=O)[nH]c13)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G09 compound treatment 1.5357406E8 1.78E7 0.22 1.51509518E8 1.62E7 0.28 0.3533 0.9942 1296353 TimTec1_001197 CCOC(=O)c1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G10 compound treatment 1.67655794E8 3.18E7 0.4 1.66691908E8 3.14E7 0.54 0.662 0.9894 3209886 TimTec1_001198 OC(=O)c1c(SC(C#N)c2ccc(Cl)cc2)nc(cc1c3ccccc3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G11 compound treatment 1.34520496E8 -1300000.0 -0.02 1.25764132E8 -9570000.0 -0.16 -0.1273 -0.7735 1298662 TimTec1_001199 COC(=O)C1=C(C)NC(=C(C#N)C1c2ccc3OCCOc3c2)SCC(=O)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G12 compound treatment 1.22411033E8 -1.34E7 -0.17 9.5071606E7 -4.03E7 -0.69 -0.6062 -0.8546 1652210 TimTec1_001200 COC(=O)C1=C(N)OC(=C(C1c2ccc(OC)c(OC)c2)C(=O)OC)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G13 compound treatment 1.32761634E8 -3050000.0 -0.04 1.4771679E8 1.24E7 0.21 0.1228 0.57 1672888 TimTec1_001201 Oc1cc(=O)c2sc3nc(c4cccnc4)c5CCCCc5c3c2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G14 compound treatment 1.45891142E8 1.01E7 0.13 1.42527114E8 7190000.0 0.12 0.1764 0.9999 1564023 TimTec1_001202 CC(C)c1ccc(cc1)C2C3CN(C)CC=C3C(C#N)(C#N)C(=C2C#N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G15 compound treatment 1.14160875E8 -2.17E7 -0.27 1.01784856E8 -3.35E7 -0.57 -0.5982 -0.9416 3210009 TimTec1_001203 COC(=O)C1=CN2[C@@H](C#N)[C@H](c3cccnc3)C(C2C=C1)(C(=O)OC)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G16 compound treatment 1.37015901E8 1200000.0 0.02 1.29265394E8 -6070000.0 -0.1 -0.0628 -0.5984 1397215 TimTec1_001204 CCNC(=O)c1sc(C)nc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G17 compound treatment 1.41952838E8 6140000.0 0.08 1.46888158E8 1.16E7 0.2 0.1943 0.9154 3082503 TimTec1_001205 CSc1nc(SCC(=O)C(C)C)nc(N)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G18 compound treatment 1.70541235E8 3.47E7 0.44 1.17565191E8 -1.78E7 -0.3 0.093 0.175 1115621 TimTec1_001206 CC(=O)Nc1nc2ccccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G19 compound treatment 1.45470702E8 9650000.0 0.12 1.2999801E8 -5330000.0 -0.09 0.0211 0.1389 3210010 TimTec1_001207 NC1=C(C#N)C(c2ccc(Br)cc2)c3c(N1)c4ccccc4oc3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G20 compound treatment 1.56204939E8 2.04E7 0.26 1.14152012E8 -2.12E7 -0.36 -0.0755 -0.1702 1129886 TimTec1_001208 CC1(C)C(C(=O)Nc2ccccc2C#N)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G21 compound treatment 1.71753579E8 3.59E7 0.45 1.1237442E8 -2.3E7 -0.39 0.0409 0.0684 1646804 TimTec1_001209 CC1=CC(=C(C#N)C(=S)C1CC(=O)c2cccs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G22 compound treatment 1.41048439E8 5230000.0 0.07 1.42004725E8 6670000.0 0.11 0.1272 0.9654 1362352 TimTec1_001210 Cc1ccc(cc1)S(=O)(=O)N(CCO)c2cc3CCCCc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G23 mock treatment 1.57067567E8 2.13E7 0.27 1.63022726E8 2.77E7 0.47 0.5237 0.9629 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 G24 mock treatment 1.62760664E8 2.69E7 0.34 1.57846707E8 2.25E7 0.39 0.5115 0.9979 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H01 compound treatment 1.56871979E8 2.11E7 0.26 1.07898038E8 -2.74E7 -0.47 -0.1453 -0.2697 1120313 TimTec1_001211 Cn1c2C(=O)CCCCc2c3cc(ccc13)C4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H02 compound treatment 7.5194376E7 -6.06E7 -0.76 1.12219963E8 -2.31E7 -0.4 -0.8175 -0.9536 3082508 TimTec1_001212 CC/1=NN(C(=O)\C1=C/c2c[nH]nc2c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H03 compound treatment 1.13942156E8 -2.19E7 -0.27 1.11488826E8 -2.38E7 -0.41 -0.4826 -0.9813 1013623 TimTec1_001213 NC(=O)c1nnn(Cc2ccccc2)c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H04 compound treatment 9.9799641E7 -3.6E7 -0.45 1.16075231E8 -1.93E7 -0.33 -0.5526 -0.988 3210011 TimTec1_001214 FC(F)(F)c1cc(oc(=S)c1C#N)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H05 compound treatment 1.41269926E8 5450000.0 0.07 1.50166794E8 1.48E7 0.25 0.2279 0.8667 1733044 TimTec1_001215 NC(=O)c1ccc(nc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H06 compound treatment 1.49586539E8 1.38E7 0.17 1.05413319E8 -2.99E7 -0.51 -0.24 -0.444 1733896 TimTec1_001216 O=C(NCCC(c1ccccc1)c2ccccc2)c3cc4ccccc4c(=O)o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H07 compound treatment 1.40410632E8 4590000.0 0.06 1.39204074E8 3870000.0 0.07 0.0876 0.9976 1785401 TimTec1_001217 Clc1c(NCC2CCCO2)cn[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H08 compound treatment 1.5091325E8 1.51E7 0.19 1.10620151E8 -2.47E7 -0.42 -0.1652 -0.3565 3210012 TimTec1_001218 Cc1cc(C)c(C(=O)N2Cc3ccccc3N=C2S)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H09 compound treatment 1.53212745E8 1.74E7 0.22 1.00098888E8 -3.52E7 -0.6 -0.2722 -0.4243 1181388 TimTec1_001219 O=C(Nc1ccccc1)C(=C2CCCC2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H10 compound treatment 8.1515975E7 -5.43E7 -0.68 1.1548193E8 -1.99E7 -0.34 -0.7219 -0.9484 1174029 TimTec1_001220 C(N1CCN(Cc2ccccc2)C1c3ccco3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H11 compound treatment 1.16808751E8 -1.9E7 -0.24 1.05390134E8 -2.99E7 -0.51 -0.531 -0.9394 1687568 TimTec1_001221 O=C(Nc1ccccc1C(=O)Nc2ccccc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H12 compound treatment 1.03061817E8 -3.28E7 -0.41 1.66036499E8 3.07E7 0.53 0.0811 0.1216 1393827 TimTec1_001222 CCc1ccc(cc1)C(=O)CC2OC(=O)c3c2ccc(OC)c3OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H13 compound treatment 9.0865989E7 -4.5E7 -0.56 1.00937936E8 -3.44E7 -0.59 -0.815 -0.9998 1145002 TimTec1_001223 CCC(=O)Nc1sc2CCCCCc2c1C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H14 compound treatment 1.39997338E8 4180000.0 0.05 9.4031849E7 -4.13E7 -0.71 -0.4628 -0.6529 3210013 TimTec1_001224 Clc1ccc(SC2CC(=O)N(C2=O)c3ccc(Br)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H15 compound treatment 7.4389317E7 -6.14E7 -0.77 5.9924276E7 -7.54E7 -1.29 -1.4576 -0.9696 1022241 TimTec1_001225 O=C1CCN(N1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H16 compound treatment 1.71538373E8 3.57E7 0.45 1.13734818E8 -2.16E7 -0.37 0.0554 0.0954 3082550 TimTec1_001226 CC(C)(C)c1ccc(cc1)N2C(=O)CCC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H17 compound treatment 1.58207732E8 2.24E7 0.28 9.5979828E7 -3.94E7 -0.67 -0.2777 -0.3805 3210014 TimTec1_001227 N/N=C/1\CCCc2c1[nH]c3ccc(cc23)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H18 compound treatment 1.3804641E8 2230000.0 0.03 1.35845683E8 513000.0 0.01 0.026 0.8865 1154220 TimTec1_001228 Cc1n[nH]c2oc(=O)c(Cc3cccc(C)c3)c(C)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H19 compound treatment 9.4600139E7 -4.12E7 -0.52 1.46576217E8 1.12E7 0.19 -0.2295 -0.416 1503917 TimTec1_001229 Clc1ccc(cc1)C(=O)c2oc3ccccc3c2c4cnn(c4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H20 compound treatment 1.53696217E8 1.79E7 0.22 1.06192224E8 -2.91E7 -0.5 -0.1941 -0.3549 1445779 TimTec1_001230 Fc1ccc(CSc2nc3ccccc3c(=O)n2c4ccccc4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H21 compound treatment 1.0218347E8 -3.36E7 -0.42 1.07056738E8 -2.83E7 -0.48 -0.6406 -0.9977 1530713 TimTec1_001231 O=C(NCCc1ccc(cc1)S(=O)(=O)N2CCCC2)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H22 compound treatment 1.64483417E8 2.87E7 0.36 1.62690898E8 2.74E7 0.47 0.5854 0.9915 3082554 TimTec1_001232 FC(F)(F)C1=Nc2ccccc2N(C1)c3ccc(Cl)c(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H23 mock treatment 1.42456791E8 6640000.0 0.08 1.7378928E8 3.85E7 0.66 0.5244 0.7903 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 H24 mock treatment 1.58494407E8 2.27E7 0.28 1.51212734E8 1.59E7 0.27 0.3934 0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I01 compound treatment 1.38176806E8 2360000.0 0.03 1.46816248E8 1.15E7 0.2 0.1599 0.8045 1641212 TimTec1_001233 Cc1cc(C)c(C#N)c(SCC(=O)N2CCCCC2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I02 compound treatment 1.34357257E8 -1460000.0 -0.02 1.4583168E8 1.05E7 0.18 0.1141 0.6318 1202800 TimTec1_001234 CC1=C(C#N)C(C(=C(N)O1)C(=O)OCc2ccccc2)c3cc(F)ccc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I03 compound treatment 1.38115837E8 2300000.0 0.03 1.42402381E8 7070000.0 0.12 0.106 0.8518 1249954 TimTec1_001235 CC(C)c1ccc(C)cc1OCc2ccc(N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I04 compound treatment 1.37808494E8 1990000.0 0.02 1.62762322E8 2.74E7 0.47 0.3497 0.7437 3210015 TimTec1_001236 COc1cc(OCCN2CCOCC2)ccc1C3C(=C(N)Oc4[nH]c(nc34)C(F)(F)F)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I05 compound treatment 1.27146879E8 -8670000.0 -0.11 1.55850751E8 2.05E7 0.35 0.1715 0.4663 3082557 TimTec1_001237 CC(C)c1ccc(cc1)N2C(=CC(C)(C)NC2=S)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I06 compound treatment 1.40965125E8 5150000.0 0.06 1.78642806E8 4.33E7 0.74 0.5699 0.7658 1171191 TimTec1_001238 CCCc1n[nH]c2N(C(=C(C#N)C(c3c(C)onc3Cl)c12)N)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I07 compound treatment 1.38329928E8 2510000.0 0.03 1.66526803E8 3.12E7 0.53 0.3999 0.7476 1003607 TimTec1_001239 OC(=O)c1cc(nc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I08 compound treatment 1.53210151E8 1.74E7 0.22 1.78294653E8 4.3E7 0.74 0.6743 0.879 1696034 TimTec1_001240 CC(C)OC(=O)c1cc(N)c2c(c(sc2n1)c3cccs3)c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I09 compound treatment 1.33943146E8 -1870000.0 -0.02 1.78206554E8 4.29E7 0.73 0.5023 0.6841 3082561 TimTec1_001241 NC(=O)COc1ccc(cc1)C2C(=C(N)Oc3[nH]c(nc23)c4ccccc4)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I10 compound treatment 1.80094468E8 4.43E7 0.56 1.94895973E8 5.96E7 1.02 1.1137 0.9592 1275672 TimTec1_001242 CC(C)(C)c1cc(c2cccs2)c(C#N)c(SCC(=O)Oc3ccccc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I11 compound treatment 1.59021834E8 2.32E7 0.29 1.58204993E8 2.29E7 0.39 0.4827 0.9893 1564906 TimTec1_001243 COCc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccccc3COc4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I12 compound treatment 1.44382215E8 8570000.0 0.11 1.30690681E8 -4640000.0 -0.08 0.0198 0.1481 1280361 TimTec1_001244 CC(C)(C)c1nc2C(C(=C(N)Nc2o1)C(=O)N)c3ccc(OCC#N)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I13 compound treatment 1.71237517E8 3.54E7 0.44 1.31893754E8 -3440000.0 -0.06 0.2726 0.6081 1705544 TimTec1_001245 CC(C)c1ccc(cc1)C2C(=C(N)Oc3[nH]c(C)nc23)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I14 compound treatment 1.51667162E8 1.59E7 0.2 1.25188023E8 -1.01E7 -0.17 0.0178 0.0675 1235982 TimTec1_001246 CC1=C(OC(=C(C#N)C1c2ccc(F)cc2)N)C(=O)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I15 compound treatment 1.8456033E8 4.87E7 0.61 1.31415399E8 -3920000.0 -0.07 0.385 0.6258 1422848 TimTec1_001247 COC(=O)C1=C(C)Oc2oc(C)cc(=O)c2C1c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I16 compound treatment 1.75141995E8 3.93E7 0.49 1.43083878E8 7750000.0 0.13 0.4427 0.8665 1729172 TimTec1_001248 Nc1sc(NCC=C)c(C(=O)c2ccc(Br)s2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I17 compound treatment 1.31223023E8 -4590000.0 -0.06 1.34761229E8 -571000.0 -0.01 -0.0477 -0.8154 1693885 TimTec1_001249 CCCc1nc2C(C(=C(N)Oc2o1)C#N)c3cccc(O)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I18 compound treatment 1.66916638E8 3.11E7 0.39 1.78473494E8 4.31E7 0.74 0.7981 0.9555 1371394 TimTec1_001250 Clc1ccccc1C(=O)NC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I19 compound treatment 1.44390237E8 8570000.0 0.11 1.38387654E8 3060000.0 0.05 0.113 0.9451 3210016 TimTec1_001251 CC1=C(C#N)C(C2=C(O1)C(=O)CCC2)c3ccccc3C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I20 compound treatment 1.62511942E8 2.67E7 0.33 1.59609296E8 2.43E7 0.42 0.5306 0.9943 3082567 TimTec1_001252 CC1(C)C(C(=O)Nc2nccs2)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I21 compound treatment 1.47695264E8 1.19E7 0.15 1.66626482E8 3.13E7 0.54 0.4842 0.8707 3210017 TimTec1_001253 COCCC(=O)C1=CSC2=C(C1c3ccncc3)C(=O)CC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I22 compound treatment 1.61859105E8 2.6E7 0.33 1.27689966E8 -7640000.0 -0.13 0.1385 0.3936 3082601 TimTec1_001254 O=c1n2CCCc2nc3scc(c4ccccc4)c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I23 mock treatment 1.57669241E8 2.19E7 0.27 1.47863616E8 1.25E7 0.21 0.3455 0.9926 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 I24 mock treatment 1.65516325E8 2.97E7 0.37 1.70045922E8 3.47E7 0.59 0.6836 0.9747 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J01 compound treatment 1.42598334E8 6780000.0 0.09 1.07829539E8 -2.75E7 -0.47 -0.2727 -0.5701 1686618 TimTec1_001255 COC(=O)C1(CC2(CC3(CC(C1)(C(=O)OC)C2=O)C(=O)OC)C(=O)OC)C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J02 compound treatment 1.52006451E8 1.62E7 0.2 1.15438067E8 -1.99E7 -0.34 -0.0972 -0.2451 3210018 TimTec1_001256 CCOc1cc(/C=C\2/SC(=N)N(C2=O)c3nccs3)ccc1OCCN4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J03 compound treatment 1.55726415E8 1.99E7 0.25 1.69378954E8 3.4E7 0.58 0.5887 0.9285 1190635 TimTec1_001257 CC1OC(NC(=O)c2ccccc2F)C(NC(=O)c3ccccc3F)OC1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J04 compound treatment 1.46672705E8 1.09E7 0.14 1.00557362E8 -3.48E7 -0.6 -0.3246 -0.5316 1013629 TimTec1_001258 OC(=O)c1cc(Cc2ccc(O)c(c2)C(=O)O)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J05 compound treatment 1.23140668E8 -1.27E7 -0.16 1.11595427E8 -2.37E7 -0.41 -0.3998 -0.9162 3082606 TimTec1_001259 Clc1ccc(OCCCC(=O)Nc2ccc3OCCOc3c2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J06 compound treatment 1.6475702E8 2.89E7 0.36 1.50841187E8 1.55E7 0.27 0.4444 0.9882 3210135 TimTec1_001260 N/C(=N/C#N)/c1sc2nc3CCCCCc3cc2c1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J07 compound treatment 1.29179095E8 -6640000.0 -0.08 1.65103191E8 2.98E7 0.51 0.3015 0.5838 3082608 TimTec1_001261 CN(C)CCNc1cn[nH]c(=O)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J08 compound treatment 1.28019797E8 -7800000.0 -0.1 1.62198603E8 2.69E7 0.46 0.256 0.5445 3210136 TimTec1_001262 CS(=O)(=O)NCCOc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J09 compound treatment 1.44921614E8 9110000.0 0.11 1.70675946E8 3.53E7 0.61 0.5086 0.826 1582682 TimTec1_001263 OC(=O)c1ccccc1NC(=O)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J10 compound treatment 1.26767217E8 -9050000.0 -0.11 1.52813147E8 1.75E7 0.3 0.1313 0.4103 1203455 TimTec1_001264 Nc1ccc(cc1)C(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J11 compound treatment 1.5911664E8 2.33E7 0.29 1.56608628E8 2.13E7 0.36 0.4642 0.9941 1327302 TimTec1_001265 Cc1ccccc1NC(=O)c2ccccc2NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J12 compound treatment 1.2550443E8 -1.03E7 -0.13 1.19445117E8 -1.59E7 -0.27 -0.2838 -0.9423 1350742 TimTec1_001266 OC(=O)c1cc(C(=O)O)c2cccc(Cl)c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J13 compound treatment 1.42153553E8 6340000.0 0.08 1.40816215E8 5480000.0 0.09 0.1226 0.9966 1127240 TimTec1_001267 CNC(=O)c1c(N)sc2CCCCCc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J14 compound treatment 1.64750478E8 2.89E7 0.36 1.52755118E8 1.74E7 0.3 0.4675 0.9952 3210137 TimTec1_001268 CC(C)(C)c1ccc(cc1)C(=O)CC(N2CCCCC2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J15 compound treatment 1.13619172E8 -2.22E7 -0.28 1.39835646E8 4500000.0 0.08 -0.1424 -0.4928 1913738 TimTec1_001269 Oc1ccc(/C=N/c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J16 compound treatment 1.68929505E8 3.31E7 0.42 1.64287445E8 2.9E7 0.5 0.6442 0.9961 1404011 TimTec1_001270 O=C(Cc1ccccc1)Oc2ccc(cc2)C3SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J17 compound treatment 1.10492175E8 -2.53E7 -0.32 1.70378932E8 3.5E7 0.6 0.1996 0.294 1230646 TimTec1_001271 C1CCC(CC1)c2ccc3c(c2)c4CCCc5nccn3c45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J18 compound treatment 1.74029865E8 3.82E7 0.48 1.52261519E8 1.69E7 0.29 0.5439 0.9709 3210138 TimTec1_001272 Clc1ccc(CSC2CC(=O)N(C2=O)c3ccc(Br)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J19 compound treatment 1.60369982E8 2.46E7 0.31 1.57566781E8 2.22E7 0.38 0.4869 0.9945 1613380 TimTec1_001273 CN1C(=O)COc2ccc(cc12)C(=O)c3ccccc3C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J20 compound treatment 1.45386543E8 9570000.0 0.12 1.34202638E8 -1130000.0 -0.02 0.0712 0.5856 1384728 TimTec1_001274 COc1ccc(NCC(C#N)C(=O)NCc2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J21 compound treatment 1.55044917E8 1.92E7 0.24 1.55972161E8 2.06E7 0.35 0.4204 0.9827 3210139 TimTec1_001275 COc1ccc(CCNC(=N)Nc2nc(C)cc(C)n2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J22 compound treatment 1.53284969E8 1.75E7 0.22 1.5611613E8 2.08E7 0.36 0.4065 0.9729 3082616 TimTec1_001276 SC1=Nc2ccccc2CN1C(=O)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J23 mock treatment 1.35775128E8 -41500.0 0.0 1.54820117E8 1.95E7 0.33 0.2355 0.706 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 J24 mock treatment 1.52808431E8 1.7E7 0.21 1.67476529E8 3.21E7 0.55 0.5398 0.9148 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K01 compound treatment 1.21486475E8 -1.43E7 -0.18 1.22289663E8 -1.3E7 -0.22 -0.285 -0.9942 3210140 TimTec1_001277 N=c1sc(C(=O)c2ccccc2)c3scc(c4ccccc4)n13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K02 compound treatment 1.16708537E8 -1.91E7 -0.24 9.9983379E7 -3.53E7 -0.61 -0.5974 -0.9178 1261528 TimTec1_001278 COc1cc(OC)cc(c1)C2C(=C(N)OC(=C2C#N)N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K03 compound treatment 1.36653889E8 837000.0 0.01 1.08835347E8 -2.65E7 -0.45 -0.3133 -0.6905 1566998 TimTec1_001279 COc1ccc(NC(=O)Nc2ccc(OC)c(OC)c2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K04 compound treatment 1.12699028E8 -2.31E7 -0.29 7.9037665E7 -5.63E7 -0.96 -0.8865 -0.8809 1394262 TimTec1_001280 COC(=O)[C@H]1[C@H](c2ccccc2)[C@@](C#N)([C@@H]3C=CC(=C(C)N13)C(=O)OC)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K05 compound treatment 1.33522919E8 -2290000.0 -0.03 9.4221496E7 -4.11E7 -0.7 -0.518 -0.7354 1004876 TimTec1_001281 OC(=O)c1cc(=O)cc(o1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K06 compound treatment 1.38232978E8 2420000.0 0.03 9.1444435E7 -4.39E7 -0.75 -0.5098 -0.678 3082619 TimTec1_001282 Cc1nc(/C=C(/N)\C#N)cn1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K07 compound treatment 1.63446686E8 2.76E7 0.35 9.7916932E7 -3.74E7 -0.64 -0.2078 -0.2853 1429878 TimTec1_001283 COc1ccc2CCC(CC3(O)C(=O)Nc4ccccc43)C(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K08 compound treatment 9.5107393E7 -4.07E7 -0.51 9.4544107E7 -4.08E7 -0.7 -0.8548 -0.9882 1203304 TimTec1_001284 Cc1sc2nc(cc(N)c2c1C)C(=O)Oc3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K09 compound treatment 8.7301727E7 -4.85E7 -0.61 7.7025864E7 -5.83E7 -1.0 -1.1361 -0.9719 3210142 TimTec1_001285 NC(=S)/C(=C\Nc1ccccc1C#N)/C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K10 compound treatment 1.18503824E8 -1.73E7 -0.22 7.875479E7 -5.66E7 -0.97 -0.8384 -0.8447 1195774 TimTec1_001286 CC(C)c1ccc(cc1)C2C(=C(Oc3[nH]c(C)nc23)C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K11 compound treatment 9.1861522E7 -4.4E7 -0.55 1.03027562E8 -3.23E7 -0.55 -0.7809 -1.0 1673016 TimTec1_001287 COc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccc(OC(C)C)c(OC)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K12 compound treatment 9.662036E7 -3.92E7 -0.49 9.5439208E7 -3.99E7 -0.68 -0.8306 -0.987 1572307 TimTec1_001288 CCCN1CC=C2C(C#N)(C#N)C(=C(C#N)C(c3ccc(OCC(=O)N)cc3)C2(C)C1)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K13 compound treatment 1.05330572E8 -3.05E7 -0.38 8.7911852E7 -4.74E7 -0.81 -0.8444 -0.941 1290293 TimTec1_001289 Cc1nc2c(OC(=C(C#N)C32CCC(CC3)c4ccccc4)N)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K14 compound treatment 1.39756405E8 3940000.0 0.05 9.9729039E7 -3.56E7 -0.61 -0.396 -0.6476 1495492 TimTec1_001290 CC(C)N1CC=C2C(C1)C(C(=C(N)C2(C#N)C#N)C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K15 compound treatment 1.07178609E8 -2.86E7 -0.36 9.6063506E7 -3.93E7 -0.67 -0.7293 -0.9569 1213258 TimTec1_001291 CCOC(=O)C(C#N)C(c1[nH]c(C)nc1O)c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K16 compound treatment 8.079505E7 -5.5E7 -0.69 1.3846758E8 3140000.0 0.05 -0.4501 -0.6502 1320005 TimTec1_001292 CCCc1cc(ccc1OC(C)C)C2C(=C(N)Nc3oc(OC)nc23)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K17 compound treatment 8.7159196E7 -4.87E7 -0.61 9.6434622E7 -3.89E7 -0.67 -0.9024 -0.9991 1432035 TimTec1_001293 CC1(C)CC(=O)C2=C(C1)N(Cc3ccccc3)C(=C(C#N)C42CCOCC4)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K18 compound treatment 1.36876498E8 1060000.0 0.01 1.40299857E8 4970000.0 0.09 0.0695 0.8079 1488829 TimTec1_001294 Clc1cccc(c1)C(=O)N(Cc2ccccc2)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K19 compound treatment 1.33545719E8 -2270000.0 -0.03 1.52487135E8 1.72E7 0.29 0.1875 0.6355 3210143 TimTec1_001295 Fc1ccc(cc1)C(=O)[C@@H]2[C@@H](C#N)[C@@](C#N)([C@@H]3N2C=Cc4ccccc34)C(=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K20 compound treatment 1.39031662E8 3220000.0 0.04 1.41347914E8 6020000.0 0.1 0.1013 0.9163 1628961 TimTec1_001296 CC1(C)C(C(=O)Nc2ccc(cc2)S(=O)(=O)c3ccc(NC(=O)C4C(C)(C)C4(C)C)cc3)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K21 compound treatment 1.39380498E8 3560000.0 0.04 1.40050483E8 4720000.0 0.08 0.0887 0.9611 1142263 TimTec1_001297 COC(=O)C1=C(C)SC(=C(C#N)C1c2ccc(OC(C)C)c(OC)c2)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K22 compound treatment 1.42767934E8 6950000.0 0.09 1.42470448E8 7140000.0 0.12 0.1481 0.9863 1427516 TimTec1_001298 O=C(N1CN(Cc2c3CCCCc3sc12)C4CCCCC4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K23 mock treatment 1.08621884E8 -2.72E7 -0.34 1.20133916E8 -1.52E7 -0.26 -0.4252 -0.9911 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 K24 mock treatment 1.49659605E8 1.38E7 0.17 1.06325285E8 -2.9E7 -0.5 -0.2283 -0.434 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L01 compound treatment 1.21531561E8 -1.43E7 -0.18 1.3121875E8 -4110000.0 -0.07 -0.1765 -0.9167 1725268 TimTec1_001299 CCc1cc2c(=O)c(coc2cc1OC(=O)C)c3ccn(n3)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L02 compound treatment 9.5557236E7 -4.03E7 -0.51 9.8786178E7 -3.65E7 -0.63 -0.7995 -0.9944 3082669 TimTec1_001300 N=C1S/C(=C/c2ccco2)/C(=O)N1c3nccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L03 compound treatment 8.9294773E7 -4.65E7 -0.58 9.2111601E7 -4.32E7 -0.74 -0.9358 -0.9931 1704974 TimTec1_001301 COC1C(OC)N(CCN1S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L04 compound treatment 1.10106712E8 -2.57E7 -0.32 1.14973438E8 -2.04E7 -0.35 -0.4745 -0.9993 1126229 TimTec1_001302 CC(C)(C)c1cc(O)cc(c1CN2CCN(CCN)CC2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L05 compound treatment 1.00984571E8 -3.48E7 -0.44 9.5609089E7 -3.97E7 -0.68 -0.7898 -0.9771 3210144 TimTec1_001303 O=C1CN2C(=C1c3nc4ccccc4c(=O)[nH]3)NC(=O)c5ccccc25 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L06 compound treatment 8.4110246E7 -5.17E7 -0.65 1.31111951E8 -4220000.0 -0.07 -0.5097 -0.781 1508923 TimTec1_001304 CN1CCC2(CC1)C(=C(N)Oc3n[nH]c(C(=O)OC(C)(C)C)c32)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L07 compound treatment 1.49539007E8 1.37E7 0.17 8.1755454E7 -5.36E7 -0.92 -0.5268 -0.5645 1206601 TimTec1_001305 O=c1[nH]nc(c2ccccc2)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L08 compound treatment 1.48386584E8 1.26E7 0.16 1.05160037E8 -3.02E7 -0.52 -0.2537 -0.4698 3210145 TimTec1_001306 COC(=O)c1ccc2ccccc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L09 compound treatment 9.5502867E7 -4.03E7 -0.51 1.19785888E8 -1.55E7 -0.27 -0.5458 -0.955 1306892 TimTec1_001307 OC(=O)c1c(NC(=O)c2ccc(Br)cc2)sc3CCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L10 compound treatment 8.1309527E7 -5.45E7 -0.68 8.6040366E7 -4.93E7 -0.84 -1.0801 -0.9946 1170047 TimTec1_001308 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L11 compound treatment 9.8137031E7 -3.77E7 -0.47 1.00587331E8 -3.47E7 -0.59 -0.7548 -0.9935 1153508 TimTec1_001309 CCc1nc2ccccc2c(=O)n1c3ccc(OC)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L12 compound treatment 9.5863005E7 -4.0E7 -0.5 1.15956928E8 -1.94E7 -0.33 -0.5889 -0.9799 1500311 TimTec1_001310 OC(=O)c1cc(O)nc2c(Cl)cccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L13 compound treatment 1.00317651E8 -3.55E7 -0.45 8.2519012E7 -5.28E7 -0.9 -0.9542 -0.9468 1714700 TimTec1_001311 CCOc1ccc(NC(=O)C(=C2CCCCCC2)C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L14 compound treatment 1.15530136E8 -2.03E7 -0.25 8.7617431E7 -4.77E7 -0.82 -0.7575 -0.8854 3210146 TimTec1_001312 CN1CCN(CC1)C(CC(=O)c2ccc(C)cc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L15 compound treatment 1.2942547E8 -6390000.0 -0.08 8.1066411E7 -5.43E7 -0.93 -0.7135 -0.7653 3082677 TimTec1_001313 C/C(=C/c1ccccc1)/C=N/c2c(C)n(C)n(c3ccccc3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L16 compound treatment 1.42857007E8 7040000.0 0.09 9.0018331E7 -4.53E7 -0.78 -0.486 -0.6226 3210147 TimTec1_001314 Clc1ccccc1C(=O)Oc2ccc(cc2)C3SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L17 compound treatment 9.2000198E7 -4.38E7 -0.55 8.9920337E7 -4.54E7 -0.78 -0.9383 -0.9856 3082679 TimTec1_001315 Clc1nsnc1N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L18 compound treatment 9.6046839E7 -3.98E7 -0.5 1.26454449E8 -8880000.0 -0.15 -0.4602 -0.8825 1080207 TimTec1_001316 CCn1c(=O)c2ccccc2[nH]c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L19 compound treatment 1.14668043E8 -2.11E7 -0.27 1.51617488E8 1.63E7 0.28 0.0095 0.0247 1587528 TimTec1_001317 Clc1nc2ccccc2n3c(nnc13)c4coc5ccccc5c4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L20 compound treatment 1.17080232E8 -1.87E7 -0.24 1.23165417E8 -1.22E7 -0.21 -0.3135 -0.9982 3082732 TimTec1_001318 OC(=O)C(CC(=O)c1ccc(Cl)cc1)Sc2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L21 compound treatment 9.4576336E7 -4.12E7 -0.52 1.38705729E8 3370000.0 0.06 -0.325 -0.6243 3210266 TimTec1_001319 N#Cc1c(SC2CCCC2)nsc1SC3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L22 compound treatment 1.39708981E8 3890000.0 0.05 1.37516267E8 2180000.0 0.04 0.061 0.9913 3210267 TimTec1_001320 Cc1n(C)c(c[n+]1c2c3CCCCCn3n(c4ccccc4)c2=O)c5ccc(C)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L23 mock treatment 1.04495547E8 -3.13E7 -0.39 1.38131014E8 2800000.0 0.05 -0.244 -0.6163 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 L24 mock treatment 1.59668603E8 2.39E7 0.3 1.20419412E8 -1.49E7 -0.26 0.0311 0.079 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M01 compound treatment 1.22812071E8 -1.3E7 -0.16 1.20100407E8 -1.52E7 -0.26 -0.2997 -0.9745 3082736 TimTec1_001321 Cc1ccc(cc1)S(=O)(=O)N2CCC(=C(O)c3ccccc23)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M02 compound treatment 1.21212841E8 -1.46E7 -0.18 1.13609014E8 -2.17E7 -0.37 -0.3925 -0.9468 3210268 TimTec1_001322 Cc1nc2C(C(=C(N)N(c2o1)c3ccccc3)C#N)c4c(C)n(nc4Cl)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M03 compound treatment 1.38203435E8 2390000.0 0.03 1.20084467E8 -1.52E7 -0.26 -0.1634 -0.6219 3082738 TimTec1_001323 Nc1cc(ccc1Oc2ccc(cc2)C3CCCCC3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M04 compound treatment 9.7198757E7 -3.86E7 -0.48 7.499666E7 -6.03E7 -1.03 -1.0729 -0.9405 1129265 TimTec1_001324 OC(=O)c1c(SCc2ccc(C#N)cc2)nc(c3cccs3)c4CCCCc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M05 compound treatment 1.43671398E8 7850000.0 0.1 1.34824446E8 -508000.0 -0.01 0.0635 0.6422 1016658 TimTec1_001325 C[N+](C)(C)CCOC(=O)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M06 compound treatment 1.37228457E8 1410000.0 0.02 1.5058046E8 1.52E7 0.26 0.1971 0.7534 1533994 TimTec1_001326 NC1=C(C#N)C(c2c(noc2N1)c3cccc(O)c3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M07 compound treatment 1.49545742E8 1.37E7 0.17 8.8844352E7 -4.65E7 -0.8 -0.4409 -0.5415 1273967 TimTec1_001327 CCOc1ccc2nc(SCC(=O)c3cccs3)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M08 compound treatment 1.39915807E8 4100000.0 0.05 1.31754001E8 -3580000.0 -0.06 -0.007 -0.0869 1285313 TimTec1_001328 CC(C)(C)C1CCC2(CC1)C(C#N)C2(C#N)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M09 compound treatment 1.25290643E8 -1.05E7 -0.13 8.0477768E7 -5.49E7 -0.94 -0.7573 -0.7987 1588817 TimTec1_001329 CNc1sc(C(=O)CC=C)c(N)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M10 compound treatment 8.161369E7 -5.42E7 -0.68 1.47405688E8 1.21E7 0.21 -0.3347 -0.4709 1441689 TimTec1_001330 CCOC(=O)c1nc2C(C(=C(N)Nc2o1)C#N)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M11 compound treatment 7.7992777E7 -5.78E7 -0.73 9.575704E7 -3.96E7 -0.68 -0.9919 -0.9994 1280958 TimTec1_001331 CCOc1ccc(cc1OC)C2C=C(N)Oc3[nH]c(COC)nc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M12 compound treatment 1.0756146E8 -2.83E7 -0.35 1.14568267E8 -2.08E7 -0.36 -0.502 -1.0 1479215 TimTec1_001332 CCc1ccc(cc1)N2C(=C(C#N)C(c3c(C)noc23)c4cccc(Cl)c4)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M13 compound treatment 1.0287947E8 -3.29E7 -0.41 1.38863333E8 3530000.0 0.06 -0.2494 -0.5973 3082744 TimTec1_001333 N#C/C=C/N(C#N)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M14 compound treatment 1.34158817E8 -1660000.0 -0.02 1.34863709E8 -469000.0 -0.01 -0.0204 -0.9143 1118063 TimTec1_001334 CCOC(=O)C1C(=C(OC(=C1C#N)N)c2ccc(Cl)cc2)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M15 compound treatment 1.33281437E8 -2540000.0 -0.03 1.37358195E8 2030000.0 0.03 0.002 0.0432 3082746 TimTec1_001335 CCOC(=O)N1CCC2(CC1)C(=C(C)Nc3oc(C)nc32)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M16 compound treatment 1.49642435E8 1.38E7 0.17 1.47031996E8 1.17E7 0.2 0.2643 0.9974 3210269 TimTec1_001336 CCCc1nc2c(o1)N(C(=O)OCC)C(=C(C#N)C32CCNCC3)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M17 compound treatment 1.41440471E8 5620000.0 0.07 9.3956989E7 -4.14E7 -0.71 -0.4509 -0.6335 1631479 TimTec1_001337 CC(C)N1C(=C(C#N)C2(CCNCC2)C(C#N)C1=O)S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M18 compound treatment 9.1509565E7 -4.43E7 -0.56 1.6262916E8 2.73E7 0.47 -0.0626 -0.0862 3210270 TimTec1_001338 CCN(CC)C(=O)c1cccc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M19 compound treatment 7.7411245E7 -5.84E7 -0.73 1.25324419E8 -1.0E7 -0.17 -0.6392 -0.8495 1388678 TimTec1_001339 COc1cc(ccc1OCCN2CCOCC2)C3C(=C(C)Nc4oc(C)nc34)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M20 compound treatment 1.34209483E8 -1610000.0 -0.02 1.07269929E8 -2.81E7 -0.48 -0.3539 -0.7361 3082750 TimTec1_001340 CCOC(=O)c1oc2ccc(/C=N\C(C)(C)C)c(Cl)c2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M21 compound treatment 1.14510529E8 -2.13E7 -0.27 1.1347591E8 -2.19E7 -0.37 -0.4535 -0.9864 3210271 TimTec1_001341 COC(=O)C1=C(OC(=C(C#N)C1c2ccccc2c3ccccc3)C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M22 compound treatment 1.33679404E8 -2140000.0 -0.03 1.19222559E8 -1.61E7 -0.28 -0.214 -0.7722 1636367 TimTec1_001342 CCCCN1COc2ccc(CCNC(=O)c3ccc(Cl)cc3)cc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M23 mock treatment 7.7124035E7 -5.87E7 -0.74 1.62860172E8 2.75E7 0.47 -0.1874 -0.2144 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 M24 mock treatment 1.32608546E8 -3210000.0 -0.04 1.36341363E8 1010000.0 0.02 -0.0162 -0.371 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N01 compound treatment 1.22613431E8 -1.32E7 -0.17 1.32352169E8 -2980000.0 -0.05 -0.1532 -0.8839 3210272 TimTec1_001343 CCc1cc2c(=O)c3c(cn4ccccc34)oc2cc1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N02 compound treatment 1.25068585E8 -1.07E7 -0.13 1.13607354E8 -2.17E7 -0.37 -0.3583 -0.9058 3082752 TimTec1_001344 Nc1nonc1N2C(=N)S/C(=C/c3ccccc3)/C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N03 compound treatment 1.36986914E8 1170000.0 0.01 8.3083479E7 -5.22E7 -0.89 -0.6221 -0.6954 1211420 TimTec1_001345 COc1ccc(cc1)C(=O)N2c3ccccc3CCc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N04 compound treatment 1.39037393E8 3220000.0 0.04 9.564111E7 -3.97E7 -0.68 -0.4519 -0.6639 1688649 TimTec1_001346 CC(=O)Nc1[nH]c2CCCCCc2c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N05 compound treatment 1.04589835E8 -3.12E7 -0.39 1.17976541E8 -1.74E7 -0.3 -0.4871 -0.9907 1368911 TimTec1_001347 Clc1c(NCc2ccco2)cnn(c3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N06 compound treatment 1.4079873E8 4980000.0 0.06 9.1010057E7 -4.43E7 -0.76 -0.4923 -0.6467 1227629 TimTec1_001348 COc1ccc(NC2CS(=O)(=O)CC2OC(=O)c3ccc(F)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N07 compound treatment 1.4187269E8 6060000.0 0.08 1.3046909E8 -4860000.0 -0.08 -0.0051 -0.0457 1520272 TimTec1_001349 O=C(Cc1ccccc1)Nc2c(cnn2c3ccccc3)C(=O)N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N08 compound treatment 1.75132327E8 3.93E7 0.49 1.01305679E8 -3.4E7 -0.58 -0.0631 -0.0827 1561090 TimTec1_001350 Cc1cc2nc(SCC(=O)NN)[nH]c2cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N09 compound treatment 1.26340892E8 -9480000.0 -0.12 1.32507581E8 -2820000.0 -0.05 -0.1182 -0.9214 1634252 TimTec1_001351 O=C(Nc1ccccc1C(=O)N2CCN(Cc3ccccc3)CC2)c4ccccn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N10 compound treatment 1.21793903E8 -1.4E7 -0.18 9.1292732E7 -4.4E7 -0.75 -0.6575 -0.8493 1534295 TimTec1_001352 COc1ccc(NC(=O)c2cccs2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N11 compound treatment 1.0004802E8 -3.58E7 -0.45 1.01884204E8 -3.34E7 -0.57 -0.7221 -0.9927 3082818 TimTec1_001353 FC(F)(F)c1nc2ccccc2c(=O)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N12 compound treatment 1.00312752E8 -3.55E7 -0.45 1.01392447E8 -3.39E7 -0.58 -0.7257 -0.9914 3210273 TimTec1_001354 Cc1cc(OCc2ccc(Br)cc2)nc(n1)c3ccccc3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N13 compound treatment 8.6040044E7 -4.98E7 -0.62 1.54761492E8 1.94E7 0.33 -0.2064 -0.2917 1039615 TimTec1_001355 O=c1n(c2ccccc2)c(nc3ccccc13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N14 compound treatment 9.2759758E7 -4.31E7 -0.54 1.17454393E8 -1.79E7 -0.31 -0.5983 -0.9638 3210274 TimTec1_001356 FC(F)(F)c1cc(NC(=O)C(=S)NCc2ccco2)ccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N15 compound treatment 1.45990917E8 1.02E7 0.13 1.48061842E8 1.27E7 0.22 0.2443 0.9675 3210275 TimTec1_001357 CCOc1nnc(NS(=O)(=O)c2ccc(/N=C/c3ccccc3O)cc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N16 compound treatment 1.07148243E8 -2.87E7 -0.36 1.03736472E8 -3.16E7 -0.54 -0.6367 -0.9803 3082822 TimTec1_001358 Cc1sc(Cc2ccc(Cl)cc2)nc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N17 compound treatment 9.9363008E7 -3.65E7 -0.46 1.05769222E8 -2.96E7 -0.51 -0.6812 -0.9987 3082824 TimTec1_001359 N=C1SCC(=O)N1c2nccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N18 compound treatment 1.26177163E8 -9640000.0 -0.12 1.24249203E8 -1.11E7 -0.19 -0.2197 -0.9763 3210276 TimTec1_001360 CCn1c(SCC(=O)Nc2cccc(Cl)c2Cl)nc3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N19 compound treatment 1.39020437E8 3200000.0 0.04 1.39682391E8 4350000.0 0.07 0.0811 0.9581 1136080 TimTec1_001361 OC(c1oc2ccccc2c1c3cnn(c3)c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N20 compound treatment 1.25246622E8 -1.06E7 -0.13 1.26558321E8 -8770000.0 -0.15 -0.2 -0.9981 3210277 TimTec1_001362 FC(F)(F)c1cccc(c1)c2nc3ccccc3c(=O)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N21 compound treatment 1.33476996E8 -2340000.0 -0.03 1.36933024E8 1600000.0 0.03 -0.0014 -0.0344 3210278 TimTec1_001363 FC(F)(F)c1cc(NC(=O)C(=S)NCCNc2cccc3ccccc23)cc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N22 compound treatment 1.24688059E8 -1.11E7 -0.14 1.3283966E8 -2490000.0 -0.04 -0.1289 -0.8829 3082828 TimTec1_001364 COc1ccc(cc1)c2cs/c(=N\Cc3ccccc3)/[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N23 mock treatment 1.3694851E8 1130000.0 0.01 1.32823897E8 -2510000.0 -0.04 -0.0203 -0.4494 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 N24 mock treatment 1.30012931E8 -5800000.0 -0.07 8.843094E7 -4.69E7 -0.8 -0.6192 -0.7681 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O01 compound treatment 1.22095128E8 -1.37E7 -0.17 1.12789675E8 -2.25E7 -0.39 -0.3946 -0.9338 1081644 TimTec1_001365 COc1cc2CCN=C(CC#N)c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O02 compound treatment 1.26254702E8 -9560000.0 -0.12 1.134461E8 -2.19E7 -0.37 -0.3497 -0.889 1714891 TimTec1_001366 COc1cc(OC)cc(c1)[C@@H]2[C@@H](C(C)(C)C)C(C#N)(C#N)[C@@H]3N2C=Cc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O03 compound treatment 1.28208007E8 -7610000.0 -0.1 7.2820577E7 -6.25E7 -1.07 -0.8241 -0.7671 3082830 TimTec1_001367 CSc1nnc(c2ccccc2)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O04 compound treatment 1.27729116E8 -8090000.0 -0.1 1.12132918E8 -2.32E7 -0.4 -0.3526 -0.8601 3210280 TimTec1_001368 CC(C)(C)OC(=O)N1C(=C(C#N)C2(CCOCC2)c3nc([nH]c13)C(F)(F)F)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O05 compound treatment 1.26945373E8 -8870000.0 -0.11 1.05621475E8 -2.97E7 -0.51 -0.4383 -0.8419 1332895 TimTec1_001369 Cc1cc(=O)oc2cc(OC3OC(CO)C(O)C(O)C3O)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O06 compound treatment 1.18571995E8 -1.72E7 -0.22 7.3560032E7 -6.18E7 -1.06 -0.9007 -0.8345 1308936 TimTec1_001370 Fc1ccc(cc1)C(=O)CSC2=C(C#N)C(=O)C(C#N)C3(CCCC3)N2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O07 compound treatment 1.25053741E8 -1.08E7 -0.14 1.02325591E8 -3.3E7 -0.57 -0.495 -0.8521 3210391 TimTec1_001371 O=C(NCCOc1ccccc1c2ccccc2)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O08 compound treatment 1.26121914E8 -9690000.0 -0.12 1.21541655E8 -1.38E7 -0.24 -0.2529 -0.9524 1195667 TimTec1_001372 Cc1ccc(cc1)C(=O)[C@@H]2[C@@H](C(C)(C)C)C(C#N)(C#N)[C@@]3(C)C=Cc4ccccc4N23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O09 compound treatment 1.1589826E8 -1.99E7 -0.25 1.08316749E8 -2.7E7 -0.46 -0.5037 -0.9582 1300208 TimTec1_001373 Nc1sc(Nc2ccccc2)c(C#N)c1C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O10 compound treatment 1.02179643E8 -3.36E7 -0.42 1.00767598E8 -3.46E7 -0.59 -0.7168 -0.9863 3210392 TimTec1_001374 COC(=O)c1ccc(cc1)[C@@H]2[C@H]3CC(CC=C3C(C#N)(C#N)C(=C2C#N)N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O11 compound treatment 1.12664308E8 -2.32E7 -0.29 1.15439357E8 -1.99E7 -0.34 -0.4462 -0.9969 1596487 TimTec1_001375 CCCc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3cccc(O)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O12 compound treatment 1.27782051E8 -8030000.0 -0.1 1.56446767E8 2.11E7 0.36 0.1843 0.4912 3082899 TimTec1_001376 COc1ccc(cc1)[C@H]2NC(=C(C#N)C(=O)[C@@H]2[n+]3ccccc3)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O13 compound treatment 1.17613007E8 -1.82E7 -0.23 1.28527481E8 -6810000.0 -0.12 -0.2438 -0.9512 3210393 TimTec1_001377 NC1=C(C#N)C(c2nc(oc2N1c3ccccc3)c4ccccc4)c5cccc(O)c5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O14 compound treatment 1.27614851E8 -8200000.0 -0.1 1.20222339E8 -1.51E7 -0.26 -0.2556 -0.9184 1397691 TimTec1_001378 CC1=C(C(C(=C(N)S1)C#N)c2ccoc2)C(=O)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O15 compound treatment 1.09507588E8 -2.63E7 -0.33 1.21384869E8 -1.39E7 -0.24 -0.4022 -0.9874 1415097 TimTec1_001379 CCCc1nc2C(C(=C(N)Nc2o1)C#N)c3ccc(OC(C)C)c(OC)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O16 compound treatment 1.07750909E8 -2.81E7 -0.35 1.21534472E8 -1.38E7 -0.24 -0.416 -0.9811 3210394 TimTec1_001380 Clc1cccc(c1)C(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O17 compound treatment 1.17482414E8 -1.83E7 -0.23 1.25679096E8 -9650000.0 -0.17 -0.2795 -0.9868 3082903 TimTec1_001381 Cc1nc2C(C(=C(N)Nc2o1)C#N)c3c[nH]nc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O18 compound treatment 1.16640894E8 -1.92E7 -0.24 1.19314027E8 -1.6E7 -0.27 -0.364 -0.9979 1268817 TimTec1_001382 COc1ccccc1NC(=O)c2ccc(cc2)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O19 compound treatment 1.08524533E8 -2.73E7 -0.34 1.13004595E8 -2.23E7 -0.38 -0.5124 -0.9985 3210395 TimTec1_001383 COc1cccc(c1)[C@@H]2[C@H]3CC(C)CC=C3C(C#N)(C#N)C(=C2C#N)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O20 compound treatment 1.16379507E8 -1.94E7 -0.24 1.40747611E8 5420000.0 0.09 -0.1069 -0.4097 1627987 TimTec1_001384 CCOC(=O)c1c(NC(=O)C)sc2C(=O)NCCCc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O21 compound treatment 9.0411467E7 -4.54E7 -0.57 7.1628549E7 -6.37E7 -1.09 -1.1738 -0.9541 1713250 TimTec1_001385 CC(C)NC(=O)CSc1cc(c2cccnc2)c3CCCCc3c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O22 compound treatment 1.0477521E8 -3.1E7 -0.39 1.00273612E8 -3.51E7 -0.6 -0.6997 -0.9781 3210396 TimTec1_001386 CCOC(=O)c1c(N)sc2C(=O)C(CCc12)Sc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O23 mock treatment 1.21870328E8 -1.39E7 -0.17 1.29467501E8 -5860000.0 -0.1 -0.1947 -0.9652 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 O24 mock treatment 1.37444941E8 1630000.0 0.02 1.2603983E8 -9290000.0 -0.16 -0.098 -0.6113 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P01 compound treatment 1.21005209E8 -1.48E7 -0.19 1.12990881E8 -2.23E7 -0.38 -0.4018 -0.945 3082907 TimTec1_001387 COc1ccc2c(=S)c(c3cc4ccccc4o3)c(C)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P02 compound treatment 1.19895655E8 -1.59E7 -0.2 1.29187531E8 -6140000.0 -0.11 -0.2156 -0.9551 1033890 TimTec1_001388 C(Cc1nc2ccccc2[nH]1)Cc3nc4ccccc4[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P03 compound treatment 1.24434797E8 -1.14E7 -0.14 1.12573758E8 -2.28E7 -0.39 -0.3764 -0.9072 3082909 TimTec1_001389 S=CC1=C2NCCCN2C3CCCCC31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P04 compound treatment 1.9027006E7 -1.17E8 -1.47 1.7783044E7 -1.18E8 -2.01 -2.4588 -0.9878 1117255 TimTec1_001390 NC(=N)c1cccc(NC(=O)Nc2cccc(c2)C(=N)N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P05 compound treatment 1.14055833E8 -2.18E7 -0.27 1.3782413E8 2490000.0 0.04 -0.1629 -0.5895 1246425 TimTec1_001391 Cc1c(NC2CS(=O)(=O)CC2O)c(=O)n(c3ccccc3)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P06 compound treatment 1.14448134E8 -2.14E7 -0.27 1.21107957E8 -1.42E7 -0.24 -0.3617 -0.9988 1671747 TimTec1_001392 O=c1c(C2=NCCCCC2)c3[nH]c(cn3n1c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P07 compound treatment 1.19401993E8 -1.64E7 -0.21 1.20542984E8 -1.48E7 -0.25 -0.3246 -0.9947 1595982 TimTec1_001393 CCCN(CCC)C(=O)c1c(NC(=O)c2ccco2)sc3CC(C)CCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P08 compound treatment 1.29078087E8 -6740000.0 -0.08 9.3743285E7 -4.16E7 -0.71 -0.5632 -0.7855 1216494 TimTec1_001394 NNC(=O)c1ccc2c(=O)[nH][nH]c(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P09 compound treatment 1.38897115E8 3080000.0 0.04 9.8850882E7 -3.65E7 -0.62 -0.4143 -0.6621 1492209 TimTec1_001395 O=c1[nH]c(nc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P10 compound treatment 1.28861641E8 -6950000.0 -0.09 1.0977229E8 -2.56E7 -0.44 -0.3711 -0.8317 1735994 TimTec1_001396 CCn1c(N)c(sc1=S)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P11 compound treatment 1.29805986E8 -6010000.0 -0.08 1.29343008E8 -5990000.0 -0.1 -0.1258 -0.9886 1341596 TimTec1_001397 CCc1nc2ccccc2c(=O)n1c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P12 compound treatment 8.3694539E7 -5.21E7 -0.65 9.0063849E7 -4.53E7 -0.77 -1.0103 -0.9964 1919107 TimTec1_001398 Cc1cc(NCCCN2CCOCC2)nc(n1)c3ccccc3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P13 compound treatment 1.13220394E8 -2.26E7 -0.28 1.2841134E8 -6920000.0 -0.12 -0.2842 -0.9251 1420208 TimTec1_001399 CCOC(=O)c1c(NC(=O)C2C(C)(C)C2(C)C)sc3CCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P14 compound treatment 1.21157318E8 -1.47E7 -0.18 1.26236798E8 -9100000.0 -0.16 -0.2401 -0.9966 1140583 TimTec1_001400 COc1ccc(C)cc1NC(=O)C(=S)NCc2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P15 compound treatment 8.3599073E7 -5.22E7 -0.66 1.19940982E8 -1.54E7 -0.26 -0.6495 -0.9199 3210397 TimTec1_001401 NC(=N)NS(=O)(=O)c1ccc(/N=C/c2ccccc2O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P16 compound treatment 1.38658457E8 2840000.0 0.04 1.29272593E8 -6060000.0 -0.1 -0.0481 -0.4389 1142293 TimTec1_001402 O=C(Oc1ccc(cc1)C2SCCS2)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P17 compound treatment 1.50501988E8 1.47E7 0.18 1.49076739E8 1.37E7 0.24 0.2966 0.9927 1739320 TimTec1_001403 Clc1ccccc1C(=O)Nc2nonc2NC=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P18 compound treatment 1.23583244E8 -1.22E7 -0.15 8.4259371E7 -5.11E7 -0.87 -0.7267 -0.8187 1453837 TimTec1_001404 O=C(Cc1ccccc1)c2ccccc2C(=O)NCc3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P19 compound treatment 1.20576041E8 -1.52E7 -0.19 1.22667186E8 -1.27E7 -0.22 -0.2885 -0.998 1670037 TimTec1_001405 CCc1cccc(CC)c1NC(=O)COc2ccccc2C(=O)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P20 compound treatment 1.1727175E8 -1.85E7 -0.23 1.36145141E8 813000.0 0.01 -0.1547 -0.6636 3210398 TimTec1_001406 CC(C)Cc1ccc(/C=C/C(=O)N2CCN(C\C=C\c3ccccc3)CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P21 compound treatment 8.5101106E7 -5.07E7 -0.64 1.28273078E8 -7060000.0 -0.12 -0.5353 -0.8266 3082991 TimTec1_001407 Cc1nc(SCc2noc(CSc3nc(C)c(C)c(C)c3C#N)n2)c(C#N)c(C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P22 compound treatment 1.13539941E8 -2.23E7 -0.28 9.1462186E7 -4.39E7 -0.75 -0.7286 -0.9093 3210399 TimTec1_001408 Cc1ccc2NC(=O)/C(=N\N3C(=O)c4ccccc4C3=O)/c2c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P23 mock treatment 1.15617182E8 -2.02E7 -0.25 1.36897269E8 1560000.0 0.03 -0.1602 -0.6289 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2066 P24 mock treatment 1.19193982E8 -1.66E7 -0.21 1.34878142E8 -454000.0 -0.01 -0.1529 -0.733 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A01 compound treatment 1.09651408E8 9.25E7 1.16 1.09496886E8 -3.39E7 -0.58 0.4098 0.3159 1609023 TimTec1_001409 COc1ccc(CC(=O)n2[nH]c(=O)ccc2=O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A02 compound treatment 1.17744938E8 1.01E8 1.26 1.06748119E8 -3.67E7 -0.63 0.4483 0.3181 3210400 TimTec1_001410 CCN1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A03 compound treatment 1.33439633E8 1.16E8 1.46 1.33629586E8 -9790000.0 -0.17 0.9129 0.6218 3210401 TimTec1_001411 OCC1OC(C(O)C1O)N2C3CCNC(=O)C3N=C2N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A04 compound treatment 1.57875983E8 1.41E8 1.77 1.34825025E8 -8600000.0 -0.15 1.1442 0.6459 1501937 TimTec1_001412 O=C(Nc1cccc(c1)N2CCCC2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A05 compound treatment 1.64971122E8 1.48E8 1.85 1.24805431E8 -1.86E7 -0.32 1.0858 0.5771 1302244 TimTec1_001413 CS(=O)(=O)N(Cc1ccccc1)c2ccccc2C(=O)NC3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A06 compound treatment 1.49672128E8 1.33E8 1.66 1.24303888E8 -1.91E7 -0.33 0.944 0.5572 3082998 TimTec1_001414 Nc1nc(SCc2ccccc2)n(n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A07 compound treatment 1.52576496E8 1.35E8 1.7 1.39087749E8 -4330000.0 -0.07 1.1488 0.6756 1224047 TimTec1_001415 COc1ccccc1c2nn(CNc3ccccc3)c(=S)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A08 compound treatment 1.44395286E8 1.27E8 1.6 1.29119341E8 -1.43E7 -0.24 0.9555 0.5917 3083000 TimTec1_001416 CCOC(=O)c1sc(SC)nc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A09 compound treatment 1.38506431E8 1.21E8 1.52 1.20264493E8 -2.32E7 -0.4 0.7961 0.5061 1232083 TimTec1_001417 Brc1ccc2C(=O)N(C(c3ccccc3)c4ccccc4)C(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A10 compound treatment 1.32156295E8 1.15E8 1.44 1.13163179E8 -3.03E7 -0.52 0.6538 0.4266 1258394 TimTec1_001418 CCN(CC)C(=O)c1c[nH]c2ccccc2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A11 compound treatment 1.39466493E8 1.22E8 1.53 1.18164516E8 -2.53E7 -0.43 0.7792 0.4888 1352649 TimTec1_001419 C(N1CCCN(Cc2ccccc2)C1c3ccncc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A12 compound treatment 1.39395779E8 1.22E8 1.53 9.7557039E7 -4.59E7 -0.79 0.5291 0.3072 1285436 TimTec1_001420 Brc1ccc(NC(=O)c2c[nH]c3ccccc3c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A13 compound treatment 1.59351801E8 1.42E8 1.78 1.07364664E8 -3.61E7 -0.62 0.8249 0.437 3210402 TimTec1_001421 COc1cc(cc(OC)c1OC)C/2=NOC(=O)\C2=C/c3ccc(Cl)cc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A14 compound treatment 1.70480183E8 1.53E8 1.92 1.21633366E8 -2.18E7 -0.37 1.0963 0.5596 3083004 TimTec1_001422 CC1(C)CC(=O)C2=C(C1)OC3=C(C2c4cccnc4)C(=O)CC(C)(C)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A15 compound treatment 1.5330147E8 1.36E8 1.71 1.24374968E8 -1.9E7 -0.33 0.9771 0.562 3210403 TimTec1_001423 CSc1sc(C)cc1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A16 compound treatment 1.38694537E8 1.22E8 1.52 9.163415E7 -5.18E7 -0.89 0.4512 0.2559 1473282 TimTec1_001424 N=c1[nH]c(cs1)c2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A17 compound treatment 1.8516862E7 1360000.0 0.02 1.19189027E8 -2.42E7 -0.41 -0.2813 -0.6775 1291516 TimTec1_001425 Nc1nonc1NC(=O)CSc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A18 compound treatment 1.9470756E7 2310000.0 0.03 1.36107727E8 -7310000.0 -0.13 -0.068 -0.5292 1069221 TimTec1_001426 CSc1nnnn1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A19 compound treatment 1.9104603E7 1950000.0 0.02 1.28453753E8 -1.5E7 -0.26 -0.1639 -0.6368 1502089 TimTec1_001427 COc1ccc(cc1)C2C3CCC=C3C(=C(N)C2(C#N)C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A20 compound treatment 1.7582355E7 424000.0 0.01 1.51069498E8 7650000.0 0.13 0.0963 0.7352 1057528 TimTec1_001428 CC(=O)Oc1cccc2ccc(O)nc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A21 compound treatment 1.7458694E7 301000.0 0.0 1.4732858E8 3910000.0 0.07 0.05 0.7458 3210521 TimTec1_001429 Cc1c(C)c(/C=N/O)c(C)c(C)c1/C=N/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A22 compound treatment 1.7751346E7 593000.0 0.01 1.6272715E8 1.93E7 0.33 0.2389 0.7228 1551108 TimTec1_001430 CCOC(=O)C1CCN(CC1)C(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A23 mock treatment 1.9987244E7 2830000.0 0.04 1.504214E8 7000000.0 0.12 0.1098 0.8788 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 A24 mock treatment 1.6980139E7 -178000.0 0.0 1.63878374E8 2.05E7 0.35 0.246 0.7026 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B01 compound treatment 1.01634966E8 8.45E7 1.06 1.18844875E8 -2.46E7 -0.42 0.4519 0.3963 1318272 TimTec1_001431 COc1ccc2nc(sc2c1)C(=O)N3CCN(C)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B02 compound treatment 1.17061811E8 9.99E7 1.25 1.41096764E8 -2320000.0 -0.04 0.858 0.6843 1256461 TimTec1_001432 OC(=O)c1ccc(Nc2nnc(c3ccccc3)c(n2)c4ccccc4)cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B03 compound treatment 1.267731E7 -4480000.0 -0.06 1.31759518E8 -1.17E7 -0.2 -0.1809 -0.8723 3083011 TimTec1_001433 FC(F)(F)c1cccc(c1)c2ccc(/C=C(\C#N)/c3ccccc3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B04 compound treatment 1.24472496E8 1.07E8 1.35 1.63769677E8 2.03E7 0.35 1.1982 0.8617 3210522 TimTec1_001434 C(C1COC(=N1)C2=N[C@@H](Cc3ccccc3)CO2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B05 compound treatment 1.3941361E7 -3220000.0 -0.04 1.53723863E8 1.03E7 0.18 0.0962 0.5316 3083012 TimTec1_001435 Cc1nnc(/N=C/2\S/C(=C/c3ccc(cc3)C(=O)O)/C(=O)N2CC=C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B06 compound treatment 1.5731548E7 -1430000.0 -0.02 1.65744322E8 2.23E7 0.38 0.2576 0.6733 3210523 TimTec1_001436 C/C(=N\O)/c1ccc2OCCOCCOCCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B07 compound treatment 1.35324E7 -3630000.0 -0.05 1.53896415E8 1.05E7 0.18 0.0946 0.5116 1208416 TimTec1_001437 O=C1N(CSc2nc3ccccc3s2)c4cccc5cccc1c45 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B08 compound treatment 1.6286055E7 -872000.0 -0.01 1.57111927E8 1.37E7 0.23 0.158 0.6734 3210524 TimTec1_001438 C[C@@H]1[C@@H]2CCC3[C@@](C)(CC(=O)O)CCC[C@]3(C)C2Cc4occc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B09 compound treatment 1.3965847E7 -3190000.0 -0.04 1.68097386E8 2.47E7 0.42 0.2704 0.6372 1668666 TimTec1_001439 C(SCc1ccccc1)c2cn3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B10 compound treatment 8.3637657E7 6.65E7 0.83 1.47726275E8 4310000.0 0.07 0.6418 0.7666 3210525 TimTec1_001440 ONC(=O)c1cccc2/C(=N\O)/c3ccccc3-c21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B11 compound treatment 8.7406859E7 7.02E7 0.88 1.62182764E8 1.88E7 0.32 0.8502 0.9065 3083091 TimTec1_001441 CCCOc1ccc(/C=C/C(=O)Nc2nnc[nH]2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B12 compound treatment 1.7974441E7 816000.0 0.01 9.992863E7 -4.35E7 -0.74 -0.5192 -0.6973 1621908 TimTec1_001442 NS(=O)(=O)c1nn2cc(nc2s1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B13 compound treatment 1.8160043E7 1000000.0 0.01 1.75688747E8 3.23E7 0.55 0.3995 0.723 1239473 TimTec1_001443 Clc1c(NCc2ccccc2)cn[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B14 compound treatment 1.57175414E8 1.4E8 1.76 1.09755633E8 -3.37E7 -0.58 0.8345 0.4514 3210526 TimTec1_001444 OC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)/C=C/c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B15 compound treatment 1.40422726E8 1.23E8 1.55 1.64919294E8 2.15E7 0.37 1.3536 0.8516 3210527 TimTec1_001445 Brc1cc(c2coc3ccccc3c2=O)c4OCOCc4c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B16 compound treatment 1.08985862E8 9.18E7 1.15 1.15017373E8 -2.84E7 -0.49 0.4707 0.3765 3083094 TimTec1_001446 COc1cc(SC#N)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B17 compound treatment 1.35767726E8 1.19E8 1.49 1.71845314E8 2.84E7 0.49 1.3962 0.8919 1121522 TimTec1_001447 COc1ccc(CCCc2nc3ccccc3[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B18 compound treatment 1.03686639E8 8.65E7 1.09 1.66778486E8 2.34E7 0.4 1.0503 0.9079 3210528 TimTec1_001448 CNC(=S)Nc1ccc(OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B19 compound treatment 1.13633599E8 9.65E7 1.21 1.60188858E8 1.68E7 0.29 1.0587 0.8512 1022826 TimTec1_001449 O=C(Nc1ccccc1)Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B20 compound treatment 1.9600187E7 2440000.0 0.03 1.65707851E8 2.23E7 0.38 0.2914 0.7614 3083097 TimTec1_001450 CC1CCCCN1C(=O)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B21 compound treatment 1.7057896E7 -100000.0 0.0 1.50908306E8 7490000.0 0.13 0.0897 0.7001 3210529 TimTec1_001451 O=C(NCc1ccco1)c2ccccc2N(Cc3ccccc3)S(=O)(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B22 compound treatment 1.3315537E7 -3840000.0 -0.05 1.3403179E8 -9390000.0 -0.16 -0.1477 -0.8804 1271782 TimTec1_001452 CC(=O)Oc1ccc2c(NC3(OC(=O)C)C(=O)c4ccccc4C23OC(=O)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B23 mock treatment 1.9447751E7 2290000.0 0.03 1.07479072E8 -3.59E7 -0.62 -0.4147 -0.6734 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 B24 mock treatment 1.6516607E7 -642000.0 -0.01 1.47181545E8 3760000.0 0.06 0.0398 0.6139 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C01 compound treatment 1.12425517E8 9.53E7 1.2 1.1142375E8 -3.2E7 -0.55 0.4578 0.3482 1645231 TimTec1_001453 CCn1cnc2c(=O)[nH][nH]c(=O)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C02 compound treatment 1.0169477E8 8.45E7 1.06 9.7199568E7 -4.62E7 -0.79 0.1904 0.1439 2086755 TimTec1_001454 CCOC(=O)N1C/C(=C\c2ccccc2)/C(=O)\C(=C\c3ccccc3)\C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C03 compound treatment 1.33547338E8 1.16E8 1.46 1.14137314E8 -2.93E7 -0.5 0.678 0.4392 1308938 TimTec1_001455 CCc1cc2c(=O)c(coc2cc1OC(C)C(=O)O)c3csc(C)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C04 compound treatment 1.47039879E8 1.3E8 1.63 1.23997253E8 -1.94E7 -0.33 0.917 0.5514 1446072 TimTec1_001456 CC1CCCN(C1)C(=O)c2cc3ccccc3oc2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C05 compound treatment 1.42267591E8 1.25E8 1.57 1.29571032E8 -1.38E7 -0.24 0.9421 0.5936 1636408 TimTec1_001457 Cc1ccc(NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)OCc4ccccc4)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C06 compound treatment 9.3725049E7 7.66E7 0.96 8.086739E7 -6.26E7 -1.07 -0.078 -0.0542 3083101 TimTec1_001458 Nc1n/c(=N\c2ccccc2)/ss1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C07 compound treatment 1.53610609E8 1.36E8 1.71 1.49144249E8 5720000.0 0.1 1.2797 0.7464 1676195 TimTec1_001459 CCSc1nc2ccccc2n1CC(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C08 compound treatment 1.39327224E8 1.22E8 1.53 6.9799243E7 -7.36E7 -1.26 0.1925 0.097 3083103 TimTec1_001460 CSc1nc(N)c(s1)C(=O)Nc2ccc(cc2)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C09 compound treatment 1.52523214E8 1.35E8 1.7 6.3781763E7 -7.96E7 -1.36 0.2368 0.1087 3210530 TimTec1_001461 Cc1nc2ccc(/N=C/c3ccccc3O)cc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C10 compound treatment 1.30531115E8 1.13E8 1.42 1.09086288E8 -3.43E7 -0.59 0.5901 0.3834 1342383 TimTec1_001462 O=C(N(Cc1ccccc1)Cc2ccccc2)c3c[nH]c4ccccc4c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C11 compound treatment 8.2206392E7 6.5E7 0.82 6.6917003E7 -7.65E7 -1.31 -0.349 -0.2262 1668351 TimTec1_001463 OC(=O)C1CCCN1C(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C12 compound treatment 1.28373506E8 1.11E8 1.4 6.3714026E7 -7.97E7 -1.36 0.0217 0.0111 1266673 TimTec1_001464 O=C(Nc1ncccn1)c2c[nH]c3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C13 compound treatment 9.4737269E7 7.76E7 0.97 6.1080469E7 -8.23E7 -1.41 -0.3085 -0.1801 3083106 TimTec1_001465 Fc1ccccc1C/2=NOC(=O)\C2=C/Nc3ccc(Cl)cn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C14 compound treatment 1.45616451E8 1.28E8 1.61 1.11989414E8 -3.14E7 -0.54 0.759 0.4468 1516165 TimTec1_001466 CCOC(=O)C1=C(C)OC(=C(C1c2cccnc2)C(=O)OCC)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C15 compound treatment 7.2812343E7 5.57E7 0.7 6.4954838E7 -7.85E7 -1.34 -0.4561 -0.3013 3083108 TimTec1_001467 CSc1sc(C)cc1/C=N/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C16 compound treatment 1.03660592E8 8.65E7 1.09 7.383996E7 -6.96E7 -1.19 -0.0749 -0.0465 3210531 TimTec1_001468 Clc1ccc(NC(=O)/N=c/2\[nH]c(cs2)c3ccccc3)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C17 compound treatment 9577012.0 -7580000.0 -0.1 8.5677974E7 -5.77E7 -0.99 -0.7662 -0.7716 3083183 TimTec1_001469 Nc1nonc1NC(=O)CSC(=N)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C18 compound treatment 1.51431577E8 1.34E8 1.68 8.3310863E7 -6.01E7 -1.03 0.4635 0.2348 1579055 TimTec1_001470 COc1ccc(cc1)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C19 compound treatment 1.6718049E7 -440000.0 -0.01 1.25406794E8 -1.8E7 -0.31 -0.222 -0.7197 1328959 TimTec1_001471 CCOc1ccc(OCC)c(c1)C2C(Cc3ccccc3)N4C(C=Cc5ccccc45)C2(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C20 compound treatment 1.0144095E7 -7010000.0 -0.09 7.2314978E7 -7.11E7 -1.22 -0.9229 -0.7562 3083185 TimTec1_001472 COC(=O)Nc1nccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C21 compound treatment 8558696.0 -8600000.0 -0.11 7.1882309E7 -7.15E7 -1.22 -0.9422 -0.7664 1288354 TimTec1_001473 Cc1ccc(c(C)c1)c2c(C#N)c(N)n(C)c(=O)c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C22 compound treatment 1.6690301E7 -468000.0 -0.01 1.05399949E8 -3.8E7 -0.65 -0.4644 -0.7135 1283442 TimTec1_001474 O=C(Nc1ccc2OCOc2c1)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C23 mock treatment 1.5962714E7 -1200000.0 -0.01 1.43057521E8 -363000.0 -0.01 -0.015 -0.9241 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 C24 mock treatment 1.7075663E7 -82400.0 0.0 1.40342578E8 -3080000.0 -0.05 -0.038 -0.7208 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D01 compound treatment 9567429.0 -7590000.0 -0.1 1.42054987E8 -1370000.0 -0.02 -0.0839 -0.8553 3083186 TimTec1_001475 O=C1CC(Sc2ccc3ccccc3c2)C4COC1O4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D02 compound treatment 1.7525058E7 367000.0 0.0 1.0469985E8 -3.87E7 -0.66 -0.4654 -0.7022 1501922 TimTec1_001476 OC(=O)c1nn(Cc2ccccc2)nc1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D03 compound treatment 8520569.0 -8640000.0 -0.11 1.24435348E8 -1.9E7 -0.32 -0.3064 -0.8945 3210532 TimTec1_001477 S/C(=C(/C(=O)c1ccccc1)\[n+]2ccccc2)/NC(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D04 compound treatment 9999658.0 -7160000.0 -0.09 1.93930104E8 5.05E7 0.86 0.5479 0.6303 3083190 TimTec1_001478 O=C(N[C@@H]1COC(=O)C1)OCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D05 compound treatment 8558810.0 -8600000.0 -0.11 1.20243036E8 -2.32E7 -0.4 -0.3568 -0.8679 3210533 TimTec1_001479 O=C(C(=C1Nc2ccccc2N1)C#N)c3cc[n+](Cc4ccccc4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D06 compound treatment 9814200.0 -7340000.0 -0.09 1.99490719E8 5.61E7 0.96 0.6135 0.6363 3083192 TimTec1_001480 OC(=O)c1ccc(/C=C/C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D07 compound treatment 9633832.0 -7520000.0 -0.09 1.05331934E8 -3.81E7 -0.65 -0.5278 -0.8011 1703831 TimTec1_001481 Brc1ccc(NC(=O)C2(CCN3CC2)c4ccccc4C3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D08 compound treatment 1.04929E7 -6670000.0 -0.08 1.02522826E8 -4.09E7 -0.7 -0.5542 -0.786 1474907 TimTec1_001482 OC1CC(c2ccccc2Cl)C3(C(C1)c4ccccc4Cl)C(=O)NC(=O)NC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D09 compound treatment 8249299.0 -8910000.0 -0.11 1.23099472E8 -2.03E7 -0.35 -0.325 -0.8895 3210647 TimTec1_001483 Cc1cccn2c(=O)c(/C=N/c3ccc(Cl)cc3)c(Sc4ccccc4)nc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D10 compound treatment 1.0404734E7 -6750000.0 -0.08 7.5413795E7 -6.8E7 -1.16 -0.8831 -0.7566 3083196 TimTec1_001484 Cc1ccc(cc1)S(=O)(=O)c2ccc(/C=C/c3ccco3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D11 compound treatment 1.3750214E7 -3410000.0 -0.04 6.6248641E7 -7.72E7 -1.32 -0.9643 -0.7296 1185515 TimTec1_001485 O=C(NCCc1nc2ccccc2[nH]1)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D12 compound treatment 9980178.0 -7180000.0 -0.09 1.05194223E8 -3.82E7 -0.65 -0.5264 -0.7969 3083198 TimTec1_001486 COc1ccc(/C=C/2\N=C(N(C2=O)c3nc4ccc(cc4s3)C(=O)O)c5ccccc5)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D13 compound treatment 1.782744E7 669000.0 0.01 8.6244517E7 -5.72E7 -0.98 -0.6861 -0.701 1329192 TimTec1_001487 Cc1cc(=O)n2c3C(=O)N(Cc4ccccc4)C(=O)c3sc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D14 compound treatment 1.7197611E7 39500.0 0.0 9.6068273E7 -4.74E7 -0.81 -0.5728 -0.7067 3210648 TimTec1_001488 CC(=O)Nc1ccc(cc1C(=O)O)S(=O)(=O)NN2C(=O)/C(=C/c3ccco3)/N=C2c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D15 compound treatment 1.8404741E7 1250000.0 0.02 1.09216299E8 -3.42E7 -0.59 -0.403 -0.688 3083200 TimTec1_001489 Cc1nnc(C)n1/N=C/c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D16 compound treatment 1.2890094E8 1.12E8 1.4 9.8601722E7 -4.48E7 -0.77 0.4487 0.2808 1026134 TimTec1_001490 O=C(c1cc2ccccc2o1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D17 compound treatment 1.6968594E7 -190000.0 0.0 8.0237836E7 -6.32E7 -1.08 -0.7665 -0.7087 1337169 TimTec1_001491 CCCC(=O)c1ccc(cc1)C(C)CCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D18 compound treatment 1.04677715E8 8.75E7 1.1 9.1837195E7 -5.16E7 -0.88 0.1519 0.1078 1082112 TimTec1_001492 COc1cccc(NC(=S)Nc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D19 compound treatment 7.5740573E7 5.86E7 0.73 7.0200149E7 -7.32E7 -1.25 -0.3666 -0.2523 1198422 TimTec1_001493 NC(=O)CCNC(=O)C(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D20 compound treatment 9883942.0 -7270000.0 -0.09 3.7851211E7 -1.06E8 -1.81 -1.3424 -0.7419 1112637 TimTec1_001494 CCC(C)NC(=O)c1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D21 compound treatment 1.7820683E7 663000.0 0.01 8.0157566E7 -6.33E7 -1.08 -0.7599 -0.7017 3210649 TimTec1_001495 Fc1ccc(cc1)c2cs/c(=N\c3ccccc3)/n2Cc4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D22 compound treatment 1.9547835E7 2390000.0 0.03 6.6779753E7 -7.66E7 -1.31 -0.9065 -0.6908 1228411 TimTec1_001496 OC1(C2C(=O)NC(=O)NC2=O)C(=O)c3ccccc3C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D23 mock treatment 1.2836114E7 -4320000.0 -0.05 1.53176998E8 9760000.0 0.17 0.0798 0.4542 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 D24 mock treatment 1.6867446E7 -291000.0 0.0 1.43279758E8 -141000.0 0.0 -0.0043 -0.9801 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E01 compound treatment 9.8011615E7 8.09E7 1.01 1.05259826E8 -3.82E7 -0.65 0.2553 0.2116 1636299 TimTec1_001497 COc1ccc2C=CC3C=CC(O)C4Oc1c2C43CCN(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E02 compound treatment 1.19905095E8 1.03E8 1.29 1.13210749E8 -3.02E7 -0.52 0.5457 0.393 3083205 TimTec1_001498 CC(C)(C)C1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E03 compound treatment 1.45757358E8 1.29E8 1.61 1.30462733E8 -1.3E7 -0.22 0.9839 0.6042 3210650 TimTec1_001499 Cn1c(=O)c(C2=NNC3=NNC(C23)c4ccccc4)c(O)c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E04 compound treatment 1.35522044E8 1.18E8 1.48 1.31271998E8 -1.21E7 -0.21 0.9029 0.6022 3083208 TimTec1_001500 O=C(N1CCCCC1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E05 compound treatment 1.44390841E8 1.27E8 1.6 1.35514741E8 -7910000.0 -0.14 1.0329 0.6448 1501857 TimTec1_001501 COc1ccc(NC(=O)CC2CS(=O)(=O)CC2CC(=O)Nc3ccc(OC)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E06 compound treatment 1.39865703E8 1.23E8 1.54 1.29576363E8 -1.38E7 -0.24 0.9209 0.5913 1493097 TimTec1_001502 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2cnnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E07 compound treatment 1.25763165E8 1.09E8 1.36 1.23831058E8 -1.96E7 -0.34 0.7262 0.5176 3210651 TimTec1_001503 Oc1ccc(/C=N/c2ccc(cc2)N3CCOCC3)cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E08 compound treatment 1.39414026E8 1.22E8 1.53 1.44465295E8 1040000.0 0.02 1.0971 0.7153 1097150 TimTec1_001504 COc1ccc(NC(=O)c2sc(SC)nc2N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E09 compound treatment 1.33583136E8 1.16E8 1.46 1.25612088E8 -1.78E7 -0.3 0.8172 0.5477 3210652 TimTec1_001505 O=C/1Nc2ccccc2\C1=N/N3C(=O)C4C=CC=CC4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E10 compound treatment 1.35605289E8 1.18E8 1.49 1.31645252E8 -1.18E7 -0.2 0.9081 0.6056 1413901 TimTec1_001506 O=C(N(c1ccccc1)c2ccccc2)c3c[nH]c4ccccc4c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E11 compound treatment 1.4363471E8 1.26E8 1.59 1.10149546E8 -3.33E7 -0.57 0.7192 0.4266 3210653 TimTec1_001507 CC(C)(C)C(=O)CSc1ncnc2[nH]cnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E12 compound treatment 1.31923691E8 1.15E8 1.44 1.16134606E8 -2.73E7 -0.47 0.6877 0.4544 1279481 TimTec1_001508 CCOC(=O)CC(N)c1ccccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E13 compound treatment 1.5976545E8 1.43E8 1.79 1.46134133E8 2710000.0 0.05 1.2978 0.7252 3210654 TimTec1_001509 CCc1sc2sncc2c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E14 compound treatment 1.42061257E8 1.25E8 1.57 1.21762097E8 -2.17E7 -0.37 0.8458 0.5253 1490642 TimTec1_001510 Cc1ccc(s1)C(C2C(=O)CC(C)(C)CC2=O)C3C(=O)CC(C)(C)CC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E15 compound treatment 1.32967343E8 1.16E8 1.45 1.22144295E8 -2.13E7 -0.36 0.7697 0.5139 3082121 TimTec1_001511 CCSc1cc(CC)sc1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E16 compound treatment 1.50616677E8 1.33E8 1.67 1.2649956E8 -1.69E7 -0.29 0.979 0.5762 3082123 TimTec1_001512 CN(C(=O)CSC(=S)N1CCCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E17 compound treatment 1.40948785E8 1.24E8 1.55 1.2560184E8 -1.78E7 -0.31 0.8824 0.5576 3210655 TimTec1_001513 CCOC(=O)/C=C(/C)\Nc1nonc1NC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E18 compound treatment 1.6095248E7 -1060000.0 -0.01 1.44999741E8 1580000.0 0.03 0.0097 0.3213 3082125 TimTec1_001514 Nc1nnc(o1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E19 compound treatment 1.851712E7 1360000.0 0.02 9.4181953E7 -4.92E7 -0.84 -0.5839 -0.6927 1386928 TimTec1_001515 Cc1ccc(C2C(Cc3ccccc3)N4C=Cc5ccccc5C4C2(C#N)C(=O)N)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E20 compound treatment 1.8776614E7 1620000.0 0.02 1.34553174E8 -8870000.0 -0.15 -0.093 -0.6071 3082127 TimTec1_001516 CCOC(=O)Cc1ccccc1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E21 compound treatment 1.6065574E7 -1090000.0 -0.01 9.3516422E7 -4.99E7 -0.85 -0.6137 -0.7184 3210656 TimTec1_001517 O=C/1/C(=C/C2CCCO2)/CC\C1=C/C3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E22 compound treatment 2.201667E7 4860000.0 0.06 1.29018292E8 -1.44E7 -0.25 -0.1312 -0.5167 1433367 TimTec1_001518 CC(C)C(=O)Nc1ccc(cc1)c2nc3cc(C)ccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E23 mock treatment 1.7403735E7 246000.0 0.0 1.34327281E8 -9090000.0 -0.16 -0.1079 -0.693 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 E24 mock treatment 1.9432662E7 2270000.0 0.03 1.22997494E8 -2.04E7 -0.35 -0.227 -0.6472 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F01 compound treatment 1.6503737E7 -654000.0 -0.01 1.23725058E8 -1.97E7 -0.34 -0.2442 -0.7241 1232600 TimTec1_001519 COCC(=O)OCC1CCCN2CCCCC12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F02 compound treatment 1.2579575E7 -4580000.0 -0.06 8.7841574E7 -5.56E7 -0.95 -0.7134 -0.7484 3082129 TimTec1_001520 CC(=O)OCc1cnn(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F03 compound treatment 1.6054118E7 -1100000.0 -0.01 1.35874605E8 -7550000.0 -0.13 -0.1011 -0.7785 3210657 TimTec1_001521 O=C(CCCN1C(=O)S/C(=C/c2ccccc2)/C1=S)NC3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F04 compound treatment 1.7312386E7 154000.0 0.0 1.2199881E8 -2.14E7 -0.37 -0.2579 -0.7034 1023719 TimTec1_001522 Clc1ncnc2n(cnc12)C3CCCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F05 compound treatment 1.2465943E7 -4690000.0 -0.06 1.01623212E8 -4.18E7 -0.72 -0.5476 -0.7627 3210658 TimTec1_001523 CCc1nnc(/N=C/2\S/C(=C/c3ccc(cc3)C(=O)O)/C(=O)N2CC=C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F06 compound treatment 1.9415184E7 2260000.0 0.03 1.26421649E8 -1.7E7 -0.29 -0.1857 -0.6353 3082133 TimTec1_001524 Brc1ccc(/C=C/C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F07 compound treatment 1.3186832E7 -3970000.0 -0.05 8.8447273E7 -5.5E7 -0.94 -0.7006 -0.7435 3082134 TimTec1_001525 Nc1nnc(CCN2C(=O)S/C(=C/c3ccccc3)/C2=O)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F08 compound treatment 1.2558446E7 -4600000.0 -0.06 1.42486655E8 -934000.0 -0.02 -0.0521 -0.8703 1022021 TimTec1_001526 CC1(C)OC2C(CO)OC(C2O1)n3cnc4c(O)ncnc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F09 compound treatment 1.6211763E7 -946000.0 -0.01 1.27564025E8 -1.59E7 -0.27 -0.2003 -0.7373 3210659 TimTec1_001527 OC(=O)COc1ccccc1/C=N/N2CCN(Cc3ccc(Cl)cc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F10 compound treatment 1.0934582E7 -6220000.0 -0.08 1.0977065E8 -3.37E7 -0.58 -0.4625 -0.7957 3210660 TimTec1_001528 CN(C)c1ccc(cc1)C2=NN(C(C2)NC(Cc3c[nH]c4ccccc34)C(=O)O)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F11 compound treatment 1.3706481E7 -3450000.0 -0.04 1.62930215E8 1.95E7 0.33 0.2055 0.6103 1300950 TimTec1_001529 O=C(CN1C(=O)c2ccccc2C1=O)Nc3nnc[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F12 compound treatment 1.8181249E7 1020000.0 0.01 1.58467237E8 1.5E7 0.26 0.1912 0.7414 1127108 TimTec1_001530 CCC(Sc1nc2cccc(CC)c2c(=O)n1c3ccc(OC)cc3)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F13 compound treatment 1.43862669E8 1.27E8 1.59 1.56704612E8 1.33E7 0.23 1.2847 0.8001 3082764 TimTec1_001531 Clc1nc(C#N)c(C#N)nc1C(=C2Nc3ccccc3N2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F14 compound treatment 1.7179458E7 21400.0 0.0 1.46703832E8 3280000.0 0.06 0.0399 0.7105 3210661 TimTec1_001532 CC(C)C(C(=O)NN1C(=O)/C(=C/c2ccccn2)/N=C1c3ccccc3)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F15 compound treatment 1.7678696E7 521000.0 0.01 1.0430882E8 -3.91E7 -0.67 -0.4688 -0.7002 3082765 TimTec1_001533 C/C=C(/C)\C(=O)OC1CC(O)(C(C)C)C2C(CC(=CCC12C)C)OC(=O)c3ccc(O)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F16 compound treatment 1.7996156E7 838000.0 0.01 9.8308809E7 -4.51E7 -0.77 -0.5386 -0.6974 1203282 TimTec1_001534 CC(O)CNC(=O)C1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F17 compound treatment 1.7152147E7 -5960.0 0.0 1.53478276E8 1.01E7 0.17 0.1217 0.7068 1114140 TimTec1_001535 COc1ccc(CCCC(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F18 compound treatment 8.6330623E7 6.92E7 0.87 1.35313045E8 -8110000.0 -0.14 0.5154 0.5866 1082103 TimTec1_001536 Fc1ccc(NC(=S)Nc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F19 compound treatment 1.42153973E8 1.25E8 1.57 1.46311865E8 2890000.0 0.05 1.1437 0.7291 1119735 TimTec1_001537 COc1ccc2[nH]cc(CCNC(=O)c3ccco3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F20 compound treatment 1.45893694E8 1.29E8 1.61 1.50510244E8 7090000.0 0.12 1.2277 0.7581 3210662 TimTec1_001538 CCOC(=O)C1=C(Nc2ccccc2)OCC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F21 compound treatment 1.7616689E7 459000.0 0.01 1.28844282E8 -1.46E7 -0.25 -0.1724 -0.6906 3082768 TimTec1_001539 CC(C)NCC(O)COc1ccc(/C=C/c2cc(C)no2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F22 compound treatment 1.2545609E7 -4610000.0 -0.06 1.37790448E8 -5630000.0 -0.1 -0.1091 -0.9702 3210663 TimTec1_001540 O=C1C(/C(=N/c2ccccc2)/c3ccccc13)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F23 mock treatment 1.2865709E7 -4290000.0 -0.05 1.30375318E8 -1.3E7 -0.22 -0.196 -0.8532 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 F24 mock treatment 1.704715E7 -111000.0 0.0 1.27234833E8 -1.62E7 -0.28 -0.1969 -0.7107 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G01 compound treatment 1.25105696E8 1.08E8 1.35 7.3871808E7 -6.95E7 -1.19 0.1157 0.0642 3210787 TimTec1_001541 CC1=C(NC(=S)NC(=O)c2ccccc2)NCc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G02 compound treatment 1.46155781E8 1.29E8 1.62 9.7662301E7 -4.58E7 -0.78 0.5904 0.3284 3082771 TimTec1_001542 N#C/C(=C\c1ccccc1/C=C(\C#N)/c2ccc3OCOc3c2)/c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G03 compound treatment 1.6277115E8 1.46E8 1.83 1.1156013E8 -3.19E7 -0.55 0.906 0.4753 3210788 TimTec1_001543 OC(=O)CC1N=Cc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G04 compound treatment 1.83169496E8 1.66E8 2.08 1.08605847E8 -3.48E7 -0.6 1.0512 0.4853 3210789 TimTec1_001544 C1Oc2ccc(/C=C/C=N/c3ccc(cc3)N4CCOCC4)cc2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G05 compound treatment 1.51294536E8 1.34E8 1.68 9.6939218E7 -4.65E7 -0.8 0.6272 0.337 1707466 TimTec1_001545 CN1CCN(CC(O)COc2ccccc2OCc3nc(C)no3)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G06 compound treatment 1.52140561E8 1.35E8 1.69 1.059981E8 -3.74E7 -0.64 0.7444 0.4112 3210790 TimTec1_001546 CC1=C(Oc2ccccc2N1)C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G07 compound treatment 1.6176431E8 1.45E8 1.81 1.01314139E8 -4.21E7 -0.72 0.773 0.396 1121781 TimTec1_001547 Cc1ccc(C)n1c2ccc(cc2)C(=O)OCC(=O)c3c(C)c(C)cc(C)c3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G08 compound treatment 1.63785027E8 1.47E8 1.84 1.1664539E8 -2.68E7 -0.46 0.9765 0.5152 1240166 TimTec1_001548 Nc1[nH]c(=S)sc1C(=O)Nc2nccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G09 compound treatment 1.40980734E8 1.24E8 1.55 6.0580525E7 -8.28E7 -1.42 0.0956 0.0455 3082775 TimTec1_001549 Brc1ccc(cc1)C2OCC(=S)N2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G10 compound treatment 1.48093411E8 1.31E8 1.64 9.2947347E7 -5.05E7 -0.86 0.5505 0.2966 1301555 TimTec1_001550 CC(C)N(CCC#N)C(=O)c1c[nH]c2ccccc2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G11 compound treatment 1.4922209E8 1.32E8 1.66 8.9743481E7 -5.37E7 -0.92 0.5217 0.2754 1162047 TimTec1_001551 OC(=O)c1ccccc1C(=O)Nc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G12 compound treatment 1.29808697E8 1.13E8 1.41 8.49733E7 -5.84E7 -1.0 0.2918 0.1685 1376806 TimTec1_001552 Cc1ccc(C)c(c1)C2C3CCCC=C3C(=C(N)C2(C#N)C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G13 compound treatment 1.65072009E8 1.48E8 1.86 1.09731011E8 -3.37E7 -0.58 0.9043 0.4654 1912519 TimTec1_001553 CN(C)Cc1cc(/C=N/C2CCCCC2)c(S)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G14 compound treatment 1.34553983E8 1.17E8 1.47 1.09926737E8 -3.35E7 -0.57 0.6359 0.4024 1339047 TimTec1_001554 CCc1ccc(s1)C(C2C(=O)CC(C)(C)CC2=O)C3C(=O)CC(C)(C)CC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G15 compound treatment 1.489648E8 1.32E8 1.65 1.37193506E8 -6230000.0 -0.11 1.0938 0.6601 3082839 TimTec1_001555 CCc1cc2cc(sc2s1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G16 compound treatment 1.71425571E8 1.54E8 1.94 1.38924204E8 -4500000.0 -0.08 1.314 0.6784 3210791 TimTec1_001556 Nc1nonc1OCCNc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G17 compound treatment 1.7530491E8 1.58E8 1.98 1.17062542E8 -2.64E7 -0.45 1.0838 0.5327 1225048 TimTec1_001557 CC(=O)Nc1nonc1NC2=CC(=O)CC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G18 compound treatment 1.879507E7 1640000.0 0.02 8.6838158E7 -5.66E7 -0.97 -0.6704 -0.692 1004952 TimTec1_001558 OC(c1nc2ccccc2[nH]1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G19 compound treatment 1.48299568E8 1.31E8 1.65 1.23030519E8 -2.04E7 -0.35 0.9165 0.5449 1382010 TimTec1_001559 CCOc1ccc(OCC)c(CC2OC(=NC2=O)c3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G20 compound treatment 2.0804831E7 3650000.0 0.05 1.38194797E8 -5230000.0 -0.09 -0.0309 -0.3076 3082843 TimTec1_001560 COc1ccc(/C=C(/C#N)\c2ccc(Cl)cc2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G21 compound treatment 1.6736483E7 -422000.0 -0.01 1.1859365E8 -2.48E7 -0.42 -0.3043 -0.7159 1449158 TimTec1_001561 Brc1cccc(c1)C(CC(=O)c2ccccc2)C(C#N)C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G22 compound treatment 1.6407488E7 -751000.0 -0.01 1.3822282E8 -5200000.0 -0.09 -0.0696 -0.7776 1173213 TimTec1_001562 Clc1ccc(Cl)c(OCC(=O)NCc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G23 mock treatment 1.7022822E7 -135000.0 0.0 1.23092049E8 -2.03E7 -0.35 -0.2473 -0.7105 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 G24 mock treatment 1.7596682E7 439000.0 0.01 1.34021E8 -9400000.0 -0.16 -0.1099 -0.6825 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H01 compound treatment 1.7800813E7 643000.0 0.01 1.45922697E8 2500000.0 0.04 0.036 0.8257 3210792 TimTec1_001563 CN12CCCCC2C(COc3ccccc3Br)CCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H02 compound treatment 1.1291263E7 -5870000.0 -0.07 1.1499019E8 -2.84E7 -0.49 -0.3962 -0.8049 3082846 TimTec1_001564 Cc1ccc(cc1)C2=NNC3(CCOC(C)(C)C3)S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H03 compound treatment 1.5666358E7 -1490000.0 -0.02 1.35279152E8 -8140000.0 -0.14 -0.1118 -0.7949 3210793 TimTec1_001565 Clc1ccccc1/C=N/C2CCS(=O)(=O)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H04 compound treatment 1.5951476E7 -1210000.0 -0.02 1.50804926E8 7380000.0 0.13 0.0787 0.618 1272351 TimTec1_001566 CC(C)(C)c1ccc2OCCOCCOCCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H05 compound treatment 9664582.0 -7490000.0 -0.09 9.0328619E7 -5.31E7 -0.91 -0.7091 -0.7761 3210794 TimTec1_001567 c1nn(c2ccccc2)c3ncn4nnnc4c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H06 compound treatment 1.2198952E7 -4960000.0 -0.06 1.04154293E8 -3.93E7 -0.67 -0.5193 -0.7693 3082850 TimTec1_001568 COc1cccc(/C=C/C(=O)O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H07 compound treatment 1.5263963E7 -1890000.0 -0.02 9.1513607E7 -5.19E7 -0.89 -0.6451 -0.7258 3210795 TimTec1_001569 COc1ccc(cc1OC)C2=N/C(=C/c3c(C)nn(c3N4CCCCC4)c5ccccc5)/C(=O)O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H08 compound treatment 1.746122E7 303000.0 0.0 9.975559E7 -4.37E7 -0.75 -0.5258 -0.7035 3210796 TimTec1_001570 Cn1c(=O)c(C/2=NNC(=O)\C2=C/c3c[nH]c4ccccc34)c(O)c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H09 compound treatment 1.7713714E7 556000.0 0.01 9.0042088E7 -5.34E7 -0.91 -0.6412 -0.7017 1574162 TimTec1_001571 CCc1cc(c2n[nH]c(C)c2c3nc4ccccc4n3C)c(O)cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H10 compound treatment 1.9998613E7 2840000.0 0.04 1.34306973E8 -9110000.0 -0.16 -0.0851 -0.5319 1654421 TimTec1_001572 CS(=O)(=O)N(Cc1ccc(cc1)C(=O)O)c2cccc(Cl)c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H11 compound treatment 1.7097469E7 -60600.0 0.0 1.57124342E8 1.37E7 0.23 0.1653 0.7048 1562719 TimTec1_001573 O=C(CCN1C(=O)c2ccccc2C1=O)Nc3nnc[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H12 compound treatment 1.6492236E7 -666000.0 -0.01 1.4944515E8 6020000.0 0.1 0.067 0.6477 3210797 TimTec1_001574 Clc1ccc(cc1)N(C(=O)Nc2ccccc2Br)C3=NCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H13 compound treatment 1.53712858E8 1.37E8 1.71 1.46869206E8 3450000.0 0.06 1.253 0.731 1779116 TimTec1_001575 CCOC(=O)CCc1n[nH]c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H14 compound treatment 1.45538532E8 1.28E8 1.61 1.12319895E8 -3.11E7 -0.53 0.7623 0.4494 3210798 TimTec1_001576 CC(=O)OC1C(OC2C(OC(=O)C)C(=O)OC12)n3ccc(=O)[nH]c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H15 compound treatment 1.24228691E8 1.07E8 1.34 1.25657202E8 -1.78E7 -0.3 0.7347 0.5335 3082856 TimTec1_001577 CC(C)C1C(O)C/C(=C/CC/C(=C/C1O)/C)/C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H16 compound treatment 1.61238109E8 1.44E8 1.81 1.5377985E8 1.04E7 0.18 1.4034 0.7728 1079739 TimTec1_001578 CS(=O)(=O)c1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H17 compound treatment 1.5711486E8 1.4E8 1.76 1.48423773E8 5000000.0 0.09 1.302 0.7407 1036359 TimTec1_001579 Cc1ccc(CCCC(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H18 compound treatment 1.52212796E8 1.35E8 1.69 1.40018605E8 -3400000.0 -0.06 1.1568 0.6824 1014539 TimTec1_001580 S=C(Nc1ccccc1)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H19 compound treatment 1.56008029E8 1.39E8 1.74 1.25300938E8 -1.81E7 -0.31 1.0123 0.5722 1593359 TimTec1_001581 Cc1ccc(cc1)c2nc3sc4C(=O)CC(C)(C)Cc4n3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H20 compound treatment 1.66727412E8 1.5E8 1.88 1.49050058E8 5630000.0 0.1 1.3949 0.7424 1240459 TimTec1_001582 CCOC(=O)C1C(=O)CN(C1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H21 compound treatment 1.6306274E7 -852000.0 -0.01 1.49722279E8 6300000.0 0.11 0.0687 0.634 3082920 TimTec1_001583 CC12CCCCC2N(CCC(=O)N)c3ccccc31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H22 compound treatment 1.7489661E7 332000.0 0.0 9.491627E7 -4.85E7 -0.83 -0.5842 -0.7036 1468638 TimTec1_001584 O=C1c2ccccc2C(=O)C1(Nc3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H23 mock treatment 1.7614398E7 456000.0 0.01 1.3281116E8 -1.06E7 -0.18 -0.1244 -0.6845 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 H24 mock treatment 1.6431222E7 -727000.0 -0.01 1.28555317E8 -1.49E7 -0.25 -0.1864 -0.732 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I01 compound treatment 1.29375934E8 1.12E8 1.41 1.18114847E8 -2.53E7 -0.43 0.6891 0.4679 1500758 TimTec1_001585 CCC(=O)NC1CC2C(OC1=O)c3cccc(C)c3NC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I02 compound treatment 1.43450548E8 1.26E8 1.58 1.41751958E8 -1670000.0 -0.03 1.1001 0.6942 3082924 TimTec1_001586 CC1CCC/C(=C\c2ccc3OCOc3c2)/C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I03 compound treatment 1.58482985E8 1.41E8 1.77 1.42333985E8 -1090000.0 -0.02 1.2404 0.6996 3210799 TimTec1_001587 COC(=O)C1(C)NC2(CCCCC2)Cc3ccccc31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I04 compound treatment 1.61962818E8 1.45E8 1.82 1.38937257E8 -4480000.0 -0.08 1.2302 0.6766 1512799 TimTec1_001588 CC(C)(C)C1CCc2c(C1)sc3NC(NC(=O)c23)c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I05 compound treatment 1.6208072E8 1.45E8 1.82 1.60185613E8 1.68E7 0.29 1.4884 0.8087 1550718 TimTec1_001589 Cc1noc(COc2ccccc2OCC(=O)N)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I06 compound treatment 1.59350132E8 1.42E8 1.78 1.46145378E8 2720000.0 0.05 1.2943 0.7253 3082927 TimTec1_001590 Cc1[nH]c(=O)n(c(=O)c1C)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I07 compound treatment 1.54313077E8 1.37E8 1.72 1.5792072E8 1.45E7 0.25 1.3921 0.8008 1716137 TimTec1_001591 CS(=O)(=O)Nc1cc(NS(=O)(=O)C)cc(c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I08 compound treatment 1.58865246E8 1.42E8 1.78 1.29410437E8 -1.4E7 -0.24 1.0874 0.6062 1611777 TimTec1_001592 COc1ccc(NC(=O)c2sc(=S)[nH]c2N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I09 compound treatment 1.58146804E8 1.41E8 1.77 1.58415855E8 1.5E7 0.26 1.4321 0.8013 3210800 TimTec1_001593 Cc1ccc(cc1)C(=O)/N=c\2/cccc[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I10 compound treatment 1.41043007E8 1.24E8 1.55 1.30124327E8 -1.33E7 -0.23 0.938 0.5972 1119826 TimTec1_001594 O=C(N1CCCCC1)c2c[nH]c3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I11 compound treatment 1.36462185E8 1.19E8 1.5 1.31217045E8 -1.22E7 -0.21 0.9105 0.6026 1603574 TimTec1_001595 Cc1sc(N)c(C(=O)N)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I12 compound treatment 1.66378561E8 1.49E8 1.87 1.33242454E8 -1.02E7 -0.17 1.2004 0.6385 1363974 TimTec1_001596 COC(=O)C1(C#N)C(C(N2C1C=Cc3ccccc23)C(=O)c4ccccc4)c5ccc(C)cc5C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I13 compound treatment 1.48000773E8 1.31E8 1.64 1.4682984E8 3410000.0 0.06 1.2019 0.7318 1916807 TimTec1_001597 CCS(=O)(=O)c1ccsc1S(=O)(=O)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I14 compound treatment 2.0553611E7 3400000.0 0.04 1.19422084E8 -2.4E7 -0.41 -0.2604 -0.6304 3082931 TimTec1_001598 NC1=C(C#N)C2=CCCCC2C(c3cccs3)C1(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I15 compound treatment 1.60926277E8 1.44E8 1.8 1.45128969E8 1710000.0 0.03 1.2959 0.7185 1914041 TimTec1_001599 CSc1sc(SC)c(CO)c1CO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I16 compound treatment 1.73532563E8 1.56E8 1.96 1.57524532E8 1.41E7 0.24 1.5578 0.7882 3082933 TimTec1_001600 CC(C)(Oc1ccccc1Cl)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I17 compound treatment 1.62880117E8 1.46E8 1.83 1.51443015E8 8020000.0 0.14 1.3897 0.7581 1737803 TimTec1_001601 CC(=O)Nc1nonc1Nc2cc(C)nn2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I18 compound treatment 1.898314E7 1830000.0 0.02 1.56878106E8 1.35E7 0.23 0.1791 0.7736 3082935 TimTec1_001602 COc1ccccc1C(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I19 compound treatment 1.53721855E8 1.37E8 1.71 1.50083113E8 6660000.0 0.11 1.292 0.7525 1115158 TimTec1_001603 Cc1cc(C)c(C)c(C(=O)O)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I20 compound treatment 1.54588102E8 1.37E8 1.72 1.6652549E8 2.31E7 0.4 1.4987 0.8473 3210920 TimTec1_001604 CCNC(=S)Nc1ccc(OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I21 compound treatment 2.554632E7 8390000.0 0.11 1.88848638E8 4.54E7 0.78 0.6243 0.7955 3082938 TimTec1_001605 Clc1ccc(/C(=C\c2ccc3OCOc3c2)/C#N)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I22 compound treatment 1.8523727E7 1370000.0 0.02 1.64982075E8 2.16E7 0.37 0.2731 0.7391 1045982 TimTec1_001606 NC(=O)NS(=O)(=O)c1ccc(N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I23 mock treatment 1.825921E7 1100000.0 0.01 1.70230434E8 2.68E7 0.46 0.3343 0.7281 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 I24 mock treatment 2.210306E7 4940000.0 0.06 1.55376031E8 1.2E7 0.2 0.1886 0.8818 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J01 compound treatment 1.7921754E7 764000.0 0.01 2.10551033E8 6.71E7 1.15 0.8193 0.713 1479505 TimTec1_001607 OCCOc1c(Cl)cc(Cl)c2cccnc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J02 compound treatment 1.9038672E7 1880000.0 0.02 1.55900505E8 1.25E7 0.21 0.1677 0.7804 1009854 TimTec1_001608 COc1ccc(cc1)C(O)C(=O)c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J03 compound treatment 1.7076473E7 -81600.0 0.0 1.57424381E8 1.4E7 0.24 0.1688 0.7041 3082941 TimTec1_001609 Cc1sc(/N=C/c2ccc(Br)s2)c(C(=O)N)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J04 compound treatment 1.8166812E7 1010000.0 0.01 1.40930518E8 -2490000.0 -0.04 -0.0212 -0.4767 1144212 TimTec1_001610 OC(=O)c1ccc2OCCOCCOCCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J05 compound treatment 1.8422962E7 1260000.0 0.02 1.57851084E8 1.44E7 0.25 0.1859 0.751 3210921 TimTec1_001611 Cc1nnc(/N=C/2\S/C(=C/c3ccccc3F)/C(=O)N2CC=C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J06 compound treatment 1.7078371E7 -79700.0 0.0 1.46818809E8 3400000.0 0.06 0.0404 0.6948 1115371 TimTec1_001612 COc1ccc(cc1)C(N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J07 compound treatment 1.84402E7 1280000.0 0.02 1.38822349E8 -4600000.0 -0.08 -0.0443 -0.5512 3083016 TimTec1_001613 Brc1ccc(cc1)N2C(=O)C3ON(C(/C=C/c4ccccc4)C3C2=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J08 compound treatment 1.8638795E7 1480000.0 0.02 1.5553613E8 1.21E7 0.21 0.1598 0.7674 1351925 TimTec1_001614 CCOC(=O)c1[nH]c(C(=O)O)c(C(=O)OCc2ccccc2)c1CCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J09 compound treatment 1.7993041E7 835000.0 0.01 1.32204428E8 -1.12E7 -0.19 -0.1284 -0.6675 3083019 TimTec1_001615 COc1cccc(/N=C/C2=C3N(CCC2)c4ccccc4C3(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J10 compound treatment 2.0133558E7 2980000.0 0.04 1.19301119E8 -2.41E7 -0.41 -0.2656 -0.6406 1286584 TimTec1_001616 O=C(NCCc1c[nH]c2ccc(OCc3ccccc3)cc12)C4CCCNC4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J11 compound treatment 1.9705479E7 2550000.0 0.03 1.53059641E8 9640000.0 0.16 0.1393 0.8287 1208195 TimTec1_001617 NNC(=O)c1cc(n[nH]1)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J12 compound treatment 1.8329405E7 1170000.0 0.01 1.34524241E8 -8900000.0 -0.15 -0.0973 -0.6359 3083022 TimTec1_001618 CC(N)(Cc1ccc2OCOc2c1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J13 compound treatment 1.82998196E8 1.66E8 2.08 1.6369658E8 2.03E7 0.35 1.7165 0.8138 3210922 TimTec1_001619 CN(C)c1ccc(/C=C\2/C(=NN(C2=O)c3nnc(C)c(=O)[nH]3)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J14 compound treatment 1.80868027E8 1.64E8 2.05 1.54474852E8 1.11E7 0.19 1.586 0.769 1414476 TimTec1_001620 Cc1ccc(NC(=O)c2cccc3-c4ccccc4C(=O)c32)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J15 compound treatment 1.53073611E8 1.36E8 1.7 1.70268116E8 2.68E7 0.46 1.5306 0.8668 1395626 TimTec1_001621 CC1C(=O)CCC2C(C)(COc3ccc4ccc(=O)oc4c3)CCCC12C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J16 compound treatment 1.40423978E8 1.23E8 1.55 1.73066583E8 2.96E7 0.51 1.4522 0.8923 1361860 TimTec1_001622 CC1(C)COC(OC1)c2ccc(O)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J17 compound treatment 1.57020225E8 1.4E8 1.75 1.78713904E8 3.53E7 0.6 1.6678 0.8988 3083025 TimTec1_001623 CC(=CC(=O)Nc1ccc(Cl)cc1)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J18 compound treatment 1.55472551E8 1.38E8 1.74 1.67417475E8 2.4E7 0.41 1.5174 0.851 3210923 TimTec1_001624 COc1ccccc1C(=O)N(C(C)C)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J19 compound treatment 1.73698843E8 1.57E8 1.96 1.681386E8 2.47E7 0.42 1.6878 0.8402 1015339 TimTec1_001625 OC(c1ccccc1)C(O)(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J20 compound treatment 1.20591675E8 1.03E8 1.3 1.66677107E8 2.33E7 0.4 1.199 0.8834 1921357 TimTec1_001626 Brc1ccccc1C2OCC3(CO2)COC(OC3)c4ccccc4Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J21 compound treatment 1.8043837E7 886000.0 0.01 1.71991429E8 2.86E7 0.49 0.3537 0.723 3083029 TimTec1_001627 C[C@]1(CCC[C@]2(C)[C@H]3CC(O)[C@](C)(C=C)C=C3CC[C@@H]12)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J22 compound treatment 1.9029616E7 1870000.0 0.02 1.71258823E8 2.78E7 0.48 0.3536 0.741 1236876 TimTec1_001628 OCCC1(C(=O)c2ccccc2C1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J23 mock treatment 1.9044912E7 1890000.0 0.02 1.77393792E8 3.4E7 0.58 0.428 0.7353 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 J24 mock treatment 1.9000117E7 1840000.0 0.02 1.54594245E8 1.12E7 0.19 0.1516 0.7868 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K01 compound treatment 1.04195207E8 8.7E7 1.09 1.01378724E8 -4.2E7 -0.72 0.2632 0.2012 1634606 TimTec1_001629 CCn1c(=O)c2C(=Nc3cc(C)ccc3Oc2c4ccccc14)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K02 compound treatment 1.28926524E8 1.12E8 1.4 1.37947263E8 -5470000.0 -0.09 0.9252 0.6584 3083031 TimTec1_001630 COc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K03 compound treatment 1.23139493E8 1.06E8 1.33 1.25048721E8 -1.84E7 -0.31 0.7177 0.5253 3210924 TimTec1_001631 COc1ccc(cc1)C2CC(=NC(=N)N2)c3cc(OC)cc(OC)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K04 compound treatment 1.24500656E8 1.07E8 1.35 1.15958459E8 -2.75E7 -0.47 0.6198 0.4345 3210925 TimTec1_001632 OC(=O)c1cccc(c1)c2ccc(/C=N\n3cnnc3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K05 compound treatment 1.30019825E8 1.13E8 1.42 1.50881932E8 7460000.0 0.13 1.0914 0.7678 1250333 TimTec1_001633 CCOC(=O)CSc1cc(Cl)c2cccc(C)c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K06 compound treatment 1.61470369E8 1.44E8 1.81 9.2775855E7 -5.06E7 -0.87 0.6671 0.3323 1029874 TimTec1_001634 CCOC(=O)C1(O)c2ccccc2-c3ccccc31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K07 compound treatment 1.35243668E8 1.18E8 1.48 1.32814101E8 -1.06E7 -0.18 0.9191 0.6158 1426581 TimTec1_001635 CC(C)c1cc(NC(=O)c2ccccc2)c(C)cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K08 compound treatment 1.42863237E8 1.26E8 1.58 1.33804371E8 -9620000.0 -0.16 0.9986 0.6299 1278979 TimTec1_001636 CN(C)c1ccc(NC(=O)c2sc(=S)[nH]c2N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K09 compound treatment 9.6869605E7 7.97E7 1.0 1.66584368E8 2.32E7 0.4 0.9874 0.918 3083036 TimTec1_001637 OC(=O)/C=C\C(=O)N1CCN(Cc2ccc3OCOc3c2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K10 compound treatment 1.02557396E8 8.54E7 1.07 1.41752315E8 -1670000.0 -0.03 0.7373 0.688 1138966 TimTec1_001638 O=C(NC1CCCCC1)c2c[nH]c3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K11 compound treatment 1.17734128E8 1.01E8 1.26 1.17982578E8 -2.54E7 -0.44 0.5842 0.4377 3210926 TimTec1_001639 CN(C1CCCCC1)C(=O)CCCOc2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K12 compound treatment 1.51872903E8 1.35E8 1.69 1.33473502E8 -9950000.0 -0.17 1.0746 0.6327 1449748 TimTec1_001640 Fc1ccc(cc1)C2C(C3C=Cc4ccccc4N3C2(C#N)C#N)C(=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K13 compound treatment 1.70786118E8 1.54E8 1.93 1.42006384E8 -1410000.0 -0.02 1.3456 0.6982 3083110 TimTec1_001641 CS(=O)(=O)c1ccc(s1)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K14 compound treatment 2.1863023E7 4700000.0 0.06 1.13504909E8 -2.99E7 -0.51 -0.3204 -0.6215 1649383 TimTec1_001642 Cc1ccc(s1)C2C3CCCC=C3C(C#N)C(N)C2(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K15 compound treatment 1.57869126E8 1.41E8 1.77 1.51301324E8 7880000.0 0.13 1.3435 0.7589 3083113 TimTec1_001643 CC1(C)C(c2nc(no2)c3ccc(Br)cc3)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K16 compound treatment 1.6346454E8 1.46E8 1.84 1.18503612E8 -2.49E7 -0.43 0.9962 0.5287 1072463 TimTec1_001644 Oc1ccc(cc1)C(c2ccc(O)cc2)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K17 compound treatment 1.88490998E8 1.71E8 2.15 1.49346597E8 5930000.0 0.1 1.5915 0.7397 3083115 TimTec1_001645 COc1cc(/C=N/c2nonc2NC(=O)C)ccc1OC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K18 compound treatment 1.57525764E8 1.4E8 1.76 1.5846326E8 1.5E7 0.26 1.4272 0.802 1266444 TimTec1_001646 OC(=O)c1ccc(COc2ccccc2)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K19 compound treatment 1.8255627E7 1100000.0 0.01 1.48017522E8 4600000.0 0.08 0.0654 0.8184 1199220 TimTec1_001647 COc1ccc(cc1)C2C(C(=O)N)C2(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K20 compound treatment 1.72949352E8 1.56E8 1.95 1.58344002E8 1.49E7 0.26 1.5626 0.7928 3083117 TimTec1_001648 CCNC(=S)Nc1c(C)cccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K21 compound treatment 1.3851795E7 -3310000.0 -0.04 1.64727715E8 2.13E7 0.36 0.2286 0.6227 3210927 TimTec1_001649 O=C/1/C(=C/c2cccc3OCOc32)/CCC\C1=C/c4cccc5OCOc54 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K22 compound treatment 9.1094782E7 7.39E7 0.93 2.25124902E8 8.17E7 1.4 1.6448 0.9801 1204849 TimTec1_001650 Oc1ccc2c(=O)c(coc2c1CN3CCCCC3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K23 mock treatment 1.031934E7 -6840000.0 -0.09 1.61726591E8 1.83E7 0.31 0.1609 0.4953 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 K24 mock treatment 1.7820249E7 662000.0 0.01 1.37532249E8 -5890000.0 -0.1 -0.0654 -0.6466 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L01 compound treatment 1.7678974E7 521000.0 0.01 1.45185664E8 1760000.0 0.03 0.026 0.8406 1427041 TimTec1_001651 C(Cn1c2ccccc2c3ccccc13)c4nc5ccccc5[nH]4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L02 compound treatment 1.2551979E7 -4610000.0 -0.06 1.1324906E8 -3.02E7 -0.52 -0.4061 -0.7813 1045556 TimTec1_001652 COc1ccc2[n+]([O-])cccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L03 compound treatment 1.07882389E8 9.07E7 1.14 9.4593497E7 -4.88E7 -0.84 0.2137 0.1514 3210928 TimTec1_001653 O=C(N1CCN(CC1)C2=NC(=O)/C(=C/c3cccs3)/S2)c4cc5ccccc5oc4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L04 compound treatment 1.3793416E7 -3360000.0 -0.04 1.22767915E8 -2.07E7 -0.35 -0.2798 -0.7859 3083122 TimTec1_001654 COc1ccc(/C=C/C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L05 compound treatment 1.2798541E7 -4360000.0 -0.05 1.07040131E8 -3.64E7 -0.62 -0.479 -0.7663 1566626 TimTec1_001655 Fc1ccc(cc1)C(CC(=O)c2cccs2)SCc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L06 compound treatment 1.3251079E7 -3910000.0 -0.05 1.07561209E8 -3.59E7 -0.61 -0.4687 -0.7611 1449697 TimTec1_001656 CC1Cc2cc(OCC(=O)O)ccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L07 compound treatment 1.1442537E7 -5720000.0 -0.07 1.20273113E8 -2.31E7 -0.4 -0.3309 -0.8217 3083124 TimTec1_001657 NC1=Cc2ccccc2CN1c3ccccc3Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L08 compound treatment 1.2486132E7 -4670000.0 -0.06 1.24494005E8 -1.89E7 -0.32 -0.2705 -0.8217 3210929 TimTec1_001658 COc1ccc(cc1)N2CC(=O)N(/N=C/c3ccccc3C(=O)O)C2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L09 compound treatment 1.2146672E7 -5010000.0 -0.06 1.14652473E8 -2.88E7 -0.49 -0.3927 -0.791 1667441 TimTec1_001659 NC(=O)c1ccccc1NC(=O)C2COc3ccccc3O2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L10 compound treatment 1.52076483E8 1.35E8 1.69 1.00585595E8 -4.28E7 -0.73 0.6783 0.3677 1921446 TimTec1_001660 CC1=CC(=O)N(CCc2c[nH]c3ccc(OCc4ccccc4)cc23)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L11 compound treatment 2.9750658E7 1.26E7 0.16 1.8970208E8 4.63E7 0.79 0.6719 0.8317 1703270 TimTec1_001661 Nc1c(C#N)c2nc(C#N)c(C#N)nc2n1Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L12 compound treatment 1.37175478E8 1.2E8 1.51 1.49518141E8 6100000.0 0.1 1.1384 0.7543 1414477 TimTec1_001662 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCc2c[nH]c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L13 compound treatment 1.16331486E8 9.92E7 1.24 1.27968759E8 -1.55E7 -0.26 0.6927 0.5446 1436746 TimTec1_001663 Nc1c(C#N)c2nc(C#N)c(C#N)nc2n1CCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L14 compound treatment 1.11468297E8 9.43E7 1.18 1.71392624E8 2.8E7 0.48 1.1751 0.9207 1148985 TimTec1_001664 CCCCC1(SCCS1)c2cc(O)cc(O)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L15 compound treatment 1.19237407E8 1.02E8 1.28 1.74263397E8 3.08E7 0.53 1.2788 0.9233 3083129 TimTec1_001665 Nc1cccc(c1)C2=NCCN2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L16 compound treatment 1.60754347E8 1.44E8 1.8 1.71859206E8 2.84E7 0.49 1.618 0.8671 3211052 TimTec1_001666 CNC(=S)Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L17 compound treatment 9.5650318E7 7.85E7 0.98 1.71498864E8 2.81E7 0.48 1.0361 0.9456 3083131 TimTec1_001667 Cc1nc2ccc(Cl)cc2n1CO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L18 compound treatment 8.7826669E7 7.07E7 0.89 1.35364649E8 -8060000.0 -0.14 0.5293 0.59 1188527 TimTec1_001668 CN1CCCc2cc(ccc12)c3ccnc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L19 compound treatment 1.1967057E8 1.03E8 1.29 1.70328138E8 2.69E7 0.46 1.235 0.9041 3211053 TimTec1_001669 CC(C)/C=c\1/[nH]c(=O)/c(=C/c2ccccc2)/[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L20 compound treatment 1.6734539E8 1.5E8 1.88 1.72190835E8 2.88E7 0.49 1.6804 0.8629 3083134 TimTec1_001670 CCOC(=O)c1sc(NC(=O)C)c(C#N)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L21 compound treatment 1.15917721E8 9.88E7 1.24 1.58315693E8 1.49E7 0.25 1.0563 0.8351 3211054 TimTec1_001671 CC[C@H]1[C@@H]2OC(=O)[C@@H](C)[C@@H]2[C@H]3C[C@@H]([C@@H]4C[C@H](C)C(=O)O4)N5CCCC[C@H]1[C@H]35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L22 compound treatment 1.2504147E7 -4650000.0 -0.06 1.56181051E8 1.28E7 0.22 0.1132 0.5005 1341798 TimTec1_001672 O=C(Nc1ccccc1)OCC2(C(=O)c3ccccc3C2=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L23 mock treatment 1.6665061E7 -493000.0 -0.01 1.59170335E8 1.57E7 0.27 0.1863 0.6907 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 L24 mock treatment 1.5165012E7 -1990000.0 -0.03 1.4535191E8 1930000.0 0.03 0.0057 0.1374 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M01 compound treatment 1.0569383E8 8.85E7 1.11 1.0165237E8 -4.18E7 -0.71 0.2798 0.2118 3083213 TimTec1_001673 C[C@@]1(CCC[C@@]2(C)[C@H]1CCc3ccc(O)cc32)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M02 compound treatment 1.32879655E8 1.16E8 1.45 1.17646281E8 -2.58E7 -0.44 0.7145 0.4709 3211055 TimTec1_001674 Clc1ccc(cc1)C(CC(=O)c2ccc(Br)cc2)C3CCCCC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M03 compound treatment 1.23587024E8 1.06E8 1.34 1.15807118E8 -2.76E7 -0.47 0.6098 0.4306 3083215 TimTec1_001675 COc1ccc2CCC3[C@@](C)(CO)CCC[C@]3(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M04 compound treatment 1.41174744E8 1.24E8 1.56 1.24178953E8 -1.92E7 -0.33 0.8672 0.5453 3211056 TimTec1_001676 COc1cc(/C=N\n2nnnc2N)cc(Cl)c1OCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M05 compound treatment 1.2354369E8 1.06E8 1.33 1.25867182E8 -1.76E7 -0.3 0.7312 0.5345 1459549 TimTec1_001677 C=CCCN1C[C@@H]2CC(C1)c3cccc(=O)n3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M06 compound treatment 1.4889019E8 1.32E8 1.65 1.29605318E8 -1.38E7 -0.24 1.0013 0.5998 1091851 TimTec1_001678 CC1=C(SCCO1)C(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M07 compound treatment 1.50231967E8 1.33E8 1.67 1.26438639E8 -1.7E7 -0.29 0.9749 0.5753 3083218 TimTec1_001679 OCn1nc(oc1=S)c2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M08 compound treatment 1.53502267E8 1.36E8 1.71 1.20382124E8 -2.3E7 -0.39 0.9305 0.5302 3211058 TimTec1_001680 CN(C)c1ccc(cc1)N/2CC(=O)S\C2=N\C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M09 compound treatment 1.4497764E8 1.28E8 1.6 1.29466089E8 -1.4E7 -0.24 0.9649 0.5952 1163310 TimTec1_001681 CN(C(=O)CSc1ccccc1C(=O)O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M10 compound treatment 1.57995586E8 1.41E8 1.77 1.15673734E8 -2.77E7 -0.47 0.9134 0.4993 1289766 TimTec1_001682 Cc1ccccc1NC(=O)c2c[nH]c3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M11 compound treatment 1.48350924E8 1.31E8 1.65 1.20425468E8 -2.3E7 -0.39 0.8854 0.5232 3211059 TimTec1_001683 O=C/1ON=C(\C1=C\C=C\c2ccccc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M12 compound treatment 1.41724337E8 1.25E8 1.56 1.16028035E8 -2.74E7 -0.47 0.7734 0.474 1227323 TimTec1_001684 O=C(C1C(c2cccnc2)C(C#N)(C#N)C3C=Cc4ccccc4N13)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M13 compound treatment 1.53423649E8 1.36E8 1.71 1.32130963E8 -1.13E7 -0.19 1.0721 0.6232 1914043 TimTec1_001685 CCSc1sc(CN(C)C)cc1/C=N/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M14 compound treatment 1.7282554E7 124000.0 0.0 1.2303507E8 -2.04E7 -0.35 -0.2457 -0.7039 1340838 TimTec1_001686 CCOC(=O)C1=C(N)Oc2[nH]nc(C)c2C1c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M15 compound treatment 1.81994359E8 1.65E8 2.07 1.40333931E8 -3090000.0 -0.05 1.4248 0.6888 1362482 TimTec1_001687 Nc1nonc1NC(=O)CSc2ncccc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M16 compound treatment 1.80135092E8 1.63E8 2.04 1.49238473E8 5820000.0 0.1 1.5161 0.7407 1375046 TimTec1_001688 NNC(=O)CSCc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M17 compound treatment 1.60560479E8 1.43E8 1.8 1.4896031E8 5540000.0 0.09 1.3391 0.7433 1460899 TimTec1_001689 CC(=O)Nc1nonc1N2CCCC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M18 compound treatment 1.82850789E8 1.66E8 2.08 1.56969573E8 1.35E7 0.23 1.6337 0.7812 1065783 TimTec1_001690 CNC(=S)Nc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M19 compound treatment 1.6847008E7 -311000.0 0.0 1.46677505E8 3260000.0 0.06 0.0367 0.656 1042406 TimTec1_001691 Clc1ccc(NC(=O)NC2CCCCC2)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M20 compound treatment 1.53229118E8 1.36E8 1.71 1.55655502E8 1.22E7 0.21 1.3551 0.788 1082102 TimTec1_001692 COc1ccc(NC(=S)Nc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M21 compound treatment 1.27454634E8 1.1E8 1.38 1.17676454E8 -2.57E7 -0.44 0.6667 0.4592 3211060 TimTec1_001693 CN1C/C(=C\c2ccccc2C)/C(=O)\C(=C\c3ccccc3C)\C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M22 compound treatment 1.6403765E7 -754000.0 -0.01 1.15800251E8 -2.76E7 -0.47 -0.341 -0.7211 3083226 TimTec1_001694 O=C(/C(=C\1/NC(=O)c2ccccc2N1)/C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M23 mock treatment 1.6707478E7 -451000.0 -0.01 1.54156957E8 1.07E7 0.18 0.126 0.685 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 M24 mock treatment 1.7543782E7 386000.0 0.0 1.46643871E8 3220000.0 0.06 0.0424 0.7662 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N01 compound treatment 1.8234366E7 1080000.0 0.01 1.64437048E8 2.1E7 0.36 0.2639 0.7331 1397605 TimTec1_001695 Cc1ccc(cc1)N(C2CCS(=O)(=O)C2)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N02 compound treatment 1.6138884E7 -1020000.0 -0.01 1.56746608E8 1.33E7 0.23 0.1523 0.6664 1024491 TimTec1_001696 COC(=O)c1ccc(=O)oc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N03 compound treatment 8.579118E7 6.86E7 0.86 1.53788688E8 1.04E7 0.18 0.7343 0.8353 3211061 TimTec1_001697 O=C(CCCN1C(=O)S/C(=C/c2ccccc2)/C1=S)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N04 compound treatment 1.1434655E7 -5720000.0 -0.07 1.05279404E8 -3.81E7 -0.65 -0.5124 -0.7802 3083229 TimTec1_001698 Brc1cccc(c1)C(=O)C2=CC3Cc4ccccc4C3C=C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N05 compound treatment 1.6056311E7 -1100000.0 -0.01 1.70925556E8 2.75E7 0.47 0.3231 0.6861 1440003 TimTec1_001699 CCc1cc(c2n[nH]c(CCC(=O)O)c2c3nc4ccccc4n3C)c(O)cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N06 compound treatment 1.2405515E7 -4750000.0 -0.06 1.09618937E8 -3.38E7 -0.58 -0.4513 -0.7759 3083231 TimTec1_001700 OC(=O)C1(SCCCS1)C2CCC3OCOC3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N07 compound treatment 1.645512E7 -703000.0 -0.01 1.66541326E8 2.31E7 0.4 0.2736 0.6912 1108575 TimTec1_001701 C[N+](=Cc1ccc(C#N)cc1)[O-] 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N08 compound treatment 1.303888E7 -4120000.0 -0.05 1.25616189E8 -1.78E7 -0.3 -0.2521 -0.8154 1363444 TimTec1_001702 OC(CN1C(=O)c2ccccc2C1=O)CN3CCN(CC3)c4ccccc4Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N09 compound treatment 1.4073456E7 -3080000.0 -0.04 1.61638541E8 1.82E7 0.31 0.1931 0.6147 1864240 TimTec1_001703 COc1cc(/C=C(\C#N)/c2ccc(Cl)cc2)ccc1OC(=O)C3COc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N10 compound treatment 1.46476321E8 1.29E8 1.62 1.52876947E8 9460000.0 0.16 1.2616 0.7738 3082142 TimTec1_001704 CC(=O)O/C(=C\c1cn(C(=O)C)c2ccccc12)/C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N11 compound treatment 1.0024384E7 -7130000.0 -0.09 1.68935042E8 2.55E7 0.44 0.2455 0.5508 1722000 TimTec1_001705 Cc1cccc(c1)N2C(=O)c3sc4nccc(=O)n4c3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N12 compound treatment 1.40152107E8 1.23E8 1.54 1.60263322E8 1.68E7 0.29 1.2949 0.825 1517994 TimTec1_001706 Cc1c[nH]c2cccc(OCC(O)CN3CCN(CC3)C(c4ccccc4)c5ccccc5)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N13 compound treatment 1.47700592E8 1.31E8 1.64 1.61154878E8 1.77E7 0.3 1.3726 0.8241 3082144 TimTec1_001707 Fc1ccc(NC(=O)CSc2nnc3ccccn23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N14 compound treatment 1.38008032E8 1.21E8 1.52 1.61498361E8 1.81E7 0.31 1.2908 0.8342 1606324 TimTec1_001708 CN(C)c1nc2ccc(OCCN3CCOCC3)cc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N15 compound treatment 1.18266805E8 1.01E8 1.27 1.75967057E8 3.25E7 0.56 1.2908 0.9318 3082146 TimTec1_001709 CC(CC(=O)O)n1ccnc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N16 compound treatment 1.06259834E8 8.91E7 1.12 1.76970116E8 3.35E7 0.57 1.1964 0.9521 3211063 TimTec1_001710 CCNC(=S)Nc1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N17 compound treatment 1.63238926E8 1.46E8 1.83 1.71987471E8 2.86E7 0.49 1.6416 0.8655 3082148 TimTec1_001711 C(CSc1nc2ccccc2o1)Sc3nc4ccccc4o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N18 compound treatment 1.52937418E8 1.36E8 1.7 1.78206585E8 3.48E7 0.6 1.6255 0.9008 1722403 TimTec1_001712 OC(OCC1Cc2ccccc2O1)C3Cc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N19 compound treatment 1.46285224E8 1.29E8 1.62 1.13995477E8 -2.94E7 -0.5 0.7892 0.4653 3211064 TimTec1_001713 COc1ccc(/C=c/2\[nH]c(=O)\c(=C/c3ccc(OC)cc3)\[nH]c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N20 compound treatment 1.48687616E8 1.32E8 1.65 1.54359557E8 1.09E7 0.19 1.2991 0.7823 1707203 TimTec1_001714 Cc1cccc(Nc2nc3nonc3nc2Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N21 compound treatment 1.56350109E8 1.39E8 1.75 1.46564005E8 3140000.0 0.05 1.2727 0.7285 3211065 TimTec1_001715 CC(C)(C)C1(O)C=C(O)C(=O)N1c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N22 compound treatment 1.7443468E7 285000.0 0.0 1.50433049E8 7010000.0 0.12 0.0874 0.7279 1565579 TimTec1_001716 O=C(OCCC1(C(=O)c2ccccc2C1=O)c3ccccc3)c4cc5ccccc5oc4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N23 mock treatment 1.7305934E7 148000.0 0.0 1.62186033E8 1.88E7 0.32 0.2284 0.7112 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 N24 mock treatment 1.7053605E7 -105000.0 0.0 1.50899637E8 7480000.0 0.13 0.0896 0.6998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O01 compound treatment 1.15255148E8 9.81E7 1.23 1.20580064E8 -2.28E7 -0.39 0.5937 0.4598 3211066 TimTec1_001717 CC1=C(C)C2C(=NC(=NC2=O)c3ccc(o3)c4ccc(cc4)C(=O)O)S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O02 compound treatment 1.1862597E8 1.01E8 1.27 1.21016581E8 -2.24E7 -0.38 0.6289 0.473 3082153 TimTec1_001718 CCOC(=O)c1[nH]c(C)c(CC(C)C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O03 compound treatment 1.37433692E8 1.2E8 1.51 1.33924987E8 -9500000.0 -0.16 0.9519 0.6273 1487341 TimTec1_001719 COc1ccc(NC(c2ccc(C)cc2)n3ncc4c(=O)n(C)c5ccccc5c34)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O04 compound treatment 1.29305748E8 1.12E8 1.41 1.19366715E8 -2.41E7 -0.41 0.7036 0.48 3082155 TimTec1_001720 Cc1sc2NC(NC(=O)c2c1C)/C=C/c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O05 compound treatment 1.15354281E8 9.82E7 1.23 7.1893646E7 -7.15E7 -1.22 0.0052 0.003 3211067 TimTec1_001721 CC[C@H]1CN2CCC3(C2C[C@@H]1/C(=C\OC)/C(=O)OC)C(=O)Nc4ccccc43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O06 compound treatment 1.33890037E8 1.17E8 1.46 1.23179277E8 -2.02E7 -0.35 0.7904 0.5253 1300191 TimTec1_001722 C(Nc1ncnc2nc[nH]c12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O07 compound treatment 1.18005368E8 1.01E8 1.27 1.25574896E8 -1.78E7 -0.31 0.6785 0.5214 3211068 TimTec1_001723 Cc1nn(c(C)c1/N=C/c2c(O)ccc3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O08 compound treatment 1.32899742E8 1.16E8 1.45 1.15214985E8 -2.82E7 -0.48 0.6853 0.4478 1782754 TimTec1_001724 OC(=O)c1c[nH]c2ccccc2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O09 compound treatment 1.17242014E8 1.0E8 1.26 1.1270902E8 -3.07E7 -0.53 0.516 0.3791 1165165 TimTec1_001725 C=CCn1nnnc1SCc2cccc(CSc3nnnn3CC=C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O10 compound treatment 1.21523533E8 1.04E8 1.31 9.5747309E7 -4.77E7 -0.82 0.3487 0.226 1284834 TimTec1_001726 CCc1ccccc1NC(=O)c2c[nH]c3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O11 compound treatment 1.16647613E8 9.95E7 1.25 1.07151757E8 -3.63E7 -0.62 0.4435 0.3182 3209092 TimTec1_001727 OC(=O)c1ccc(N/C=C/2\C(=O)ON=C2c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O12 compound treatment 1.24365254E8 1.07E8 1.34 1.20179748E8 -2.32E7 -0.4 0.6696 0.4775 1145898 TimTec1_001728 Nc1nc2CCCCCc2c(c1C#N)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O13 compound treatment 1.1885742E8 1.02E8 1.28 1.33583167E8 -9840000.0 -0.17 0.783 0.6085 3209093 TimTec1_001729 Cc1cc(C(=O)O)c(s1)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O14 compound treatment 1.8941255E7 1780000.0 0.02 1.27147433E8 -1.63E7 -0.28 -0.1812 -0.6482 1667092 TimTec1_001730 COc1ccc(cc1)c2c[nH]c(=N)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O15 compound treatment 1.54385829E8 1.37E8 1.72 1.47011212E8 3590000.0 0.06 1.2607 0.7319 1602686 TimTec1_001731 Nc1nonc1NC(=O)CSC2=NCCS2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O16 compound treatment 1.60784544E8 1.44E8 1.8 1.37686679E8 -5730000.0 -0.1 1.2046 0.6676 1216965 TimTec1_001732 COc1ccc(cc1OC)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O17 compound treatment 1.5375832E8 1.37E8 1.71 1.41242676E8 -2180000.0 -0.04 1.1853 0.6916 3209094 TimTec1_001733 CC(=O)Nc1nonc1Nc2csc(CC#N)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O18 compound treatment 1.33619414E8 1.16E8 1.46 1.35837112E8 -7580000.0 -0.13 0.9413 0.6417 3082865 TimTec1_001734 Cc1cccc(C)c1NS(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O19 compound treatment 1.43293747E8 1.26E8 1.58 1.4344561E8 24600.0 0.0 1.1192 0.7073 3209095 TimTec1_001735 OC(=O)Nc1cc(Cl)cc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O20 compound treatment 1.24258612E8 1.07E8 1.34 1.26576274E8 -1.68E7 -0.29 0.7461 0.543 3082867 TimTec1_001736 OC(=O)c1ccc(/N=C/c2ccc(o2)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O21 compound treatment 1.38083604E8 1.21E8 1.52 1.22162974E8 -2.13E7 -0.36 0.8153 0.5227 1913174 TimTec1_001737 CN1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O22 compound treatment 2.0746426E7 3590000.0 0.05 1.27026167E8 -1.64E7 -0.28 -0.1666 -0.5862 1594528 TimTec1_001738 NC(=O)c1ccc(OC2CSC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O23 mock treatment 1.6607311E7 -551000.0 -0.01 1.35110354E8 -8310000.0 -0.14 -0.1055 -0.7406 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 O24 mock treatment 1.9419483E7 2260000.0 0.03 1.33674905E8 -9750000.0 -0.17 -0.0979 -0.5786 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P01 compound treatment 1.7020171E7 -138000.0 0.0 1.51028635E8 7610000.0 0.13 0.0909 0.6976 1562676 TimTec1_001739 S=c1oc(Cc2ccccc2)nn1CN3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P02 compound treatment 1.1967987E7 -5190000.0 -0.07 1.39175016E8 -4250000.0 -0.07 -0.0974 -0.9985 1066227 TimTec1_001740 CC(=O)Nc1nc(C)cs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P03 compound treatment 1.30440926E8 1.13E8 1.42 1.35253565E8 -8170000.0 -0.14 0.906 0.6345 3209096 TimTec1_001741 Cc1cc(C(=O)CSc2nnc3ccccn23)c(C)n1c4ccc(C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P04 compound treatment 9682430.0 -7480000.0 -0.09 1.8892669E7 -1.25E8 -2.13 -1.5736 -0.7375 1472764 TimTec1_001742 OCCNC(=O)c1ccc2OCCOCCOCCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P05 compound treatment 1.7511164E7 353000.0 0.0 1.24111628E8 -1.93E7 -0.33 -0.2306 -0.6976 1707455 TimTec1_001743 C(N1CCCc2ccccc12)c3cn4ccccc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P06 compound treatment 1.5306072E7 -1850000.0 -0.02 1.1266505E8 -3.08E7 -0.53 -0.3887 -0.7376 1631427 TimTec1_001744 COc1ccc2c(CCC3=C(C)C(=O)CCC32C)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P07 compound treatment 1.1314397E7 -5840000.0 -0.07 1.30673841E8 -1.27E7 -0.22 -0.2061 -0.8955 1684686 TimTec1_001745 N1C(Nc2cccc3cccc1c23)c4ccncc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P08 compound treatment 1.6055642E7 -1100000.0 -0.01 1.1249847E8 -3.09E7 -0.53 -0.3841 -0.7253 1244779 TimTec1_001746 C(OCc1ccccc1)C(CSc2ccccc2)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P09 compound treatment 1.6880122E7 -278000.0 0.0 1.35627257E8 -7790000.0 -0.13 -0.0968 -0.7253 3082946 TimTec1_001747 Clc1ccccc1/C=C/C(=O)Nc2nnc[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P10 compound treatment 1.50528747E8 1.33E8 1.67 1.06736975E8 -3.67E7 -0.63 0.739 0.4135 3209097 TimTec1_001748 O=C/1OC(=N\C1=C/c2c[nH]c3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P11 compound treatment 1.2146496E7 -5010000.0 -0.06 1.38132713E8 -5290000.0 -0.09 -0.1085 -0.9841 1718471 TimTec1_001749 CCCc1cc(=O)n2c3C(=O)N(Cc4ccccc4)C(=O)c3sc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P12 compound treatment 2.8246095E7 1.11E7 0.14 1.51222256E8 7800000.0 0.13 0.1928 0.9998 1434439 TimTec1_001750 Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P13 compound treatment 1.03716215E8 8.66E7 1.09 1.05176817E8 -3.82E7 -0.65 0.3049 0.2405 3209098 TimTec1_001751 Cc1nnc(C)n1/N=C/C=C\c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P14 compound treatment 1.42129992E8 1.25E8 1.57 9.7938107E7 -4.55E7 -0.78 0.558 0.3188 1284591 TimTec1_001752 CS(=O)(=O)Cc1ccc(Oc2ccc(NS(=O)(=O)C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P15 compound treatment 1.20920395E8 1.04E8 1.3 1.13060867E8 -3.04E7 -0.52 0.5529 0.3945 1689423 TimTec1_001753 COc1cc-2c(CC3N(C)CCc4c(OC)c(OC)c(OC)c2c34)cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P16 compound treatment 1.50175888E8 1.33E8 1.67 1.25282336E8 -1.81E7 -0.31 0.9604 0.5658 3082952 TimTec1_001754 CCNC(=S)N1CCOCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P17 compound treatment 1.40296507E8 1.23E8 1.54 1.43724498E8 304000.0 0.01 1.096 0.7095 1735540 TimTec1_001755 CCCCn1c(=O)oc2cc(Br)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P18 compound treatment 1.55304939E8 1.38E8 1.73 1.54111411E8 1.07E7 0.18 1.3548 0.7775 3209099 TimTec1_001756 FC(F)(F)c1cccc(NC(=O)CSc2cccc3cccnc23)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P19 compound treatment 1.36122006E8 1.19E8 1.49 1.39456869E8 -3960000.0 -0.07 1.0073 0.6743 3082954 TimTec1_001757 CCN1CC(=O)N(C1=S)c2ccccc2OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P20 compound treatment 1.44695905E8 1.28E8 1.6 1.48050827E8 4630000.0 0.08 1.1873 0.7412 1412266 TimTec1_001758 CC(=O)n1c2ccc(C)cc2c3nc4ccccc4nc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P21 compound treatment 1.43661509E8 1.27E8 1.59 1.40408512E8 -3010000.0 -0.05 1.0857 0.6838 3209100 TimTec1_001759 Cc1cn(C2CC(NC(=O)C(C)(C)C)C(CO)O2)c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P22 compound treatment 1.2385106E7 -4770000.0 -0.06 1.22651598E8 -2.08E7 -0.36 -0.2937 -0.8147 1065752 TimTec1_001760 O=C1C(=Cc2c[nH]c3ccccc23)C(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P23 mock treatment 1.5984989E7 -1170000.0 -0.01 1.26182968E8 -1.72E7 -0.3 -0.2191 -0.7415 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2067 P24 mock treatment 1.8971851E7 1810000.0 0.02 1.37008989E8 -6410000.0 -0.11 -0.0615 -0.5489 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A01 compound treatment 2.745365E7 -1.28E8 -1.61 1.02381839E8 -4.59E7 -0.79 -1.6923 -0.9458 3082958 TimTec1_001761 O=C1C(=Cc2cccnc2)C(=O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A02 compound treatment 8.9369068E7 -6.62E7 -0.83 1.42917678E8 -5360000.0 -0.09 -0.6524 -0.7805 3209101 TimTec1_001762 COc1ccc2S/C(=C/3\OC(=S)N(C)C3=O)/N(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A03 compound treatment 9.7824506E7 -5.78E7 -0.72 1.39345483E8 -8940000.0 -0.15 -0.6207 -0.8379 1919999 TimTec1_001763 Cc1cc(Br)c(c(Br)c1)S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A04 compound treatment 1.02789889E8 -5.28E7 -0.66 1.46542131E8 -1740000.0 -0.03 -0.4895 -0.7381 1199633 TimTec1_001764 NS(=O)(=O)c1ccc(NC(=O)COc2ccc(F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A05 compound treatment 1.20064094E8 -3.55E7 -0.45 1.66547329E8 1.83E7 0.31 -0.0941 -0.1729 1313236 TimTec1_001765 Cc1ccc(OCC(=O)O)c(c1)c2ccno2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A06 compound treatment 1.2062745E8 -3.5E7 -0.44 1.51613154E8 3330000.0 0.06 -0.2699 -0.61 1074315 TimTec1_001766 Cc1ccc(cc1)c2nc3ccccc3c(=O)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A07 compound treatment 1.27251489E8 -2.84E7 -0.36 1.46501469E8 -1780000.0 -0.03 -0.273 -0.7649 1096423 TimTec1_001767 COc1cc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2cc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A08 compound treatment 1.41212399E8 -1.44E7 -0.18 1.68379894E8 2.01E7 0.34 0.1156 0.2976 3209102 TimTec1_001768 Cc1ccc(s1)C(=O)CSCC(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A09 compound treatment 1.32164559E8 -2.34E7 -0.29 1.57306355E8 9030000.0 0.15 -0.0987 -0.297 1239893 TimTec1_001769 CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccccc2)(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A10 compound treatment 1.50447183E8 -5160000.0 -0.06 1.71005895E8 2.27E7 0.39 0.2293 0.5816 1315182 TimTec1_001770 Cc1cccc(n1)C2Nc3ccccc3C(=O)N2CCc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A11 compound treatment 1.3121711E8 -2.44E7 -0.31 1.55661312E8 7380000.0 0.13 -0.127 -0.3836 1522752 TimTec1_001771 COc1ccccc1c2oc3ccccc3c(=O)c2OC(=O)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A12 compound treatment 1.44348607E8 -1.13E7 -0.14 1.28231912E8 -2.0E7 -0.34 -0.3425 -0.9229 1519057 TimTec1_001772 CC(NC(=O)COc1ccccc1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A13 compound treatment 1.48529125E8 -7070000.0 -0.09 1.45593086E8 -2690000.0 -0.05 -0.0953 -0.9532 3082964 TimTec1_001773 COC(=O)c1sc2nc(C)cc(c2c1N)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A14 compound treatment 1.4728529E8 -8320000.0 -0.1 1.11993574E8 -3.63E7 -0.62 -0.513 -0.8145 1723203 TimTec1_001774 NNC(=O)C(O)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A15 compound treatment 1.31193526E8 -2.44E7 -0.31 1.59054453E8 1.08E7 0.18 -0.0861 -0.2409 3209103 TimTec1_001775 COc1ccc(/C=C\2/SC(=S)NC2=O)cc1COc3ccc(F)cc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A16 compound treatment 1.72859559E8 1.73E7 0.22 1.19733459E8 -2.85E7 -0.49 -0.1925 -0.3601 1432060 TimTec1_001776 NNC(=O)c1ccc(COc2cc(Cl)ccc2Cl)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A17 compound treatment 1.77171539E8 2.16E7 0.27 1.91391592E8 4.31E7 0.74 0.7132 0.9073 1236095 TimTec1_001777 COc1ccc(cc1)c2cc([nH]c(=S)c2C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A18 compound treatment 1.5041796E8 -5180000.0 -0.07 1.55669278E8 7390000.0 0.13 0.0434 0.3055 1129328 TimTec1_001778 COc1ccccc1CCNC(=O)c2ccc(COc3ccccc3Cl)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A19 compound treatment 1.67062899E8 1.15E7 0.14 2.08751499E8 6.05E7 1.04 0.8336 0.7977 3083042 TimTec1_001779 Oc1ccc(Br)cc1/C=N/n2cnc3sc4CCCCc4c3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A20 compound treatment 1.32029189E8 -2.36E7 -0.3 1.92427295E8 4.41E7 0.76 0.3253 0.4008 1178649 TimTec1_001780 COc1ccc(NC(=O)c2ccc(CSc3ccccn3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A21 compound treatment 1.82355074E8 2.68E7 0.34 1.2137612E8 -2.69E7 -0.46 -0.0884 -0.155 1547489 TimTec1_001781 CCOC(=O)COc1ccc(Br)cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A22 compound treatment 1.64173417E8 8570000.0 0.11 1.82985437E8 3.47E7 0.59 0.4961 0.8217 3209104 TimTec1_001782 CC(C)(C)S(=O)(=O)c1ccccc1/C=N/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A23 mock treatment 1.58213863E8 2610000.0 0.03 1.604053E8 1.21E7 0.21 0.1699 0.8087 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 A24 mock treatment 1.57468472E8 1870000.0 0.02 1.89953585E8 4.17E7 0.71 0.521 0.7299 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B01 compound treatment 1.68162204E8 1.26E7 0.16 1.39933975E8 -8350000.0 -0.14 0.0104 0.0488 3083046 TimTec1_001783 N/C(=N\O)/C(=O)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B02 compound treatment 1.62377751E8 6780000.0 0.08 1.42633279E8 -5650000.0 -0.1 -0.0083 -0.0641 1679359 TimTec1_001784 OC(=O)CCCN1C(=O)CSC1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B03 compound treatment 1.66339467E8 1.07E7 0.13 1.12423447E8 -3.59E7 -0.61 -0.3388 -0.5391 3209105 TimTec1_001785 CC(c1cc(Cl)ccc1[N+]#[C-])S(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B04 compound treatment 1.20611505E8 -3.5E7 -0.44 1.17370983E8 -3.09E7 -0.53 -0.6845 -0.9957 1620877 TimTec1_001786 CC(C)(C)c1nc(C#N)c(o1)N2CCC(CC2)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B05 compound treatment 1.54595068E8 -1010000.0 -0.01 1.42853173E8 -5430000.0 -0.09 -0.0746 -0.7959 1533552 TimTec1_001787 CC(Oc1ccc(Cl)cc1Cl)C(=O)NCCC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B06 compound treatment 1.06504621E8 -4.91E7 -0.62 1.06272819E8 -4.2E7 -0.72 -0.944 -0.997 3083049 TimTec1_001788 Brc1ccc2C(C#N)C(C=Cc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B07 compound treatment 1.61818311E8 6220000.0 0.08 1.54555979E8 6280000.0 0.11 0.1311 0.9876 1606872 TimTec1_001789 CCOC(=O)C1=C(C)N(C(=C(C#N)C1c2ccc(Br)cc2)N)c3nonc3NC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B08 compound treatment 1.74087249E8 1.85E7 0.23 1.0971511E8 -3.86E7 -0.66 -0.3028 -0.4328 3083051 TimTec1_001790 O=C(NC1=SC2=C(CCCC2)C1C#N)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B09 compound treatment 1.53860643E8 -1740000.0 -0.02 1.05546113E8 -4.27E7 -0.73 -0.5327 -0.7279 3209106 TimTec1_001791 CCOC(=O)c1c(N)c[nH]c1NCc2ccc(Cl)nc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B10 compound treatment 1.30005342E8 -2.56E7 -0.32 1.16258761E8 -3.2E7 -0.55 -0.6147 -0.9675 3209225 TimTec1_001792 Cc1c(/C=C/2\S/C(=N/c3ccccc3)/N(C4CCCC4)C2=O)c5ccccc5n1CC(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B11 compound treatment 9.7345184E7 -5.83E7 -0.73 1.56212775E8 7930000.0 0.14 -0.4207 -0.566 1450803 TimTec1_001793 CCN(CC)c1nc2ccccc2c(=O)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B12 compound treatment 1.08483696E8 -4.71E7 -0.59 1.44314525E8 -3970000.0 -0.07 -0.466 -0.7832 3083054 TimTec1_001794 COc1ccc(cc1)c2nn(CN3CCOCC3)c(=S)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B13 compound treatment 1.0727416E8 -4.83E7 -0.61 9.2479046E7 -5.58E7 -0.96 -1.1041 -0.9759 1437460 TimTec1_001795 Cc1nn(c2SC(=C3C(c12)c4ccccc4OC3=O)N)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B14 compound treatment 1.12232511E8 -4.34E7 -0.54 1.7756007E8 2.93E7 0.5 -0.0303 -0.041 1123272 TimTec1_001796 CSc1nc2ccc(cc2s1)S(=O)(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B15 compound treatment 1.42058119E8 -1.35E7 -0.17 9.596354E7 -5.23E7 -0.9 -0.7534 -0.8265 3209226 TimTec1_001797 CC1CS/C(=C(/C(=O)O)\C(=O)/C=C/c2cccc(O)c2)/S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B16 compound treatment 1.51490409E8 -4110000.0 -0.05 1.52180839E8 3900000.0 0.07 0.0107 0.1272 1179029 TimTec1_001798 C(Cn1c(CSc2nc3ccccc3o2)nc4ccccc14)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B17 compound treatment 1.91823102E8 3.62E7 0.45 1.03211129E8 -4.51E7 -0.77 -0.2242 -0.2504 3209227 TimTec1_001799 OC(=O)C(Cc1c[nH]cn1)NC2CNN=C2c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B18 compound treatment 1.82171017E8 2.66E7 0.33 1.10860999E8 -3.74E7 -0.64 -0.2173 -0.3009 3209228 TimTec1_001800 Cc1ccc(cc1)C2=NNC(S2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B19 compound treatment 1.35155497E8 -2.04E7 -0.26 1.24608242E8 -2.37E7 -0.41 -0.4679 -0.9757 1431685 TimTec1_001801 Fc1cccc(Cl)c1c2nc(=S)[nH]c3[nH]c(=S)[nH]c(=S)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B20 compound treatment 1.62605779E8 7000000.0 0.09 1.01433424E8 -4.68E7 -0.8 -0.5049 -0.6259 1251757 TimTec1_001802 Fc1ccc(CSc2ccccc2C(=O)NC3CC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B21 compound treatment 1.55182479E8 -420000.0 -0.01 1.11478818E8 -3.68E7 -0.63 -0.4492 -0.713 3209229 TimTec1_001803 NC(=O)c1c(NC(=S)NC(=O)c2ccccc2Cl)sc3CCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B22 compound treatment 1.25641982E8 -3.0E7 -0.38 1.13235967E8 -3.5E7 -0.6 -0.6899 -0.9746 1601676 TimTec1_001804 O=C(COc1ccccc1)Nc2ccc(cc2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B23 mock treatment 1.66054344E8 1.05E7 0.13 1.61925998E8 1.36E7 0.23 0.2579 0.9627 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 B24 mock treatment 1.519563E8 -3650000.0 -0.05 1.53269648E8 4990000.0 0.09 0.028 0.2895 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C01 compound treatment 4.3401592E7 -1.12E8 -1.41 1.08446201E8 -3.98E7 -0.68 -1.4774 -0.9447 1124602 TimTec1_001805 CCCC(=O)CC(C1C(=O)c2ccccc2C1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C02 compound treatment 1.20453304E8 -3.51E7 -0.44 8.8884799E7 -5.94E7 -1.02 -1.0307 -0.9301 1456543 TimTec1_001806 NC(=S)Nc1ccc(cc1)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C03 compound treatment 1.3656519E8 -1.9E7 -0.24 8.4241474E7 -6.4E7 -1.1 -0.944 -0.8414 3083139 TimTec1_001807 CN(C(=S)SCc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C04 compound treatment 1.36678222E8 -1.89E7 -0.24 6.4073169E7 -8.42E7 -1.44 -1.1871 -0.8126 3209230 TimTec1_001808 COc1ccc(cc1)C2NNC(=S)S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C05 compound treatment 1.61119127E8 5520000.0 0.07 7.0013976E7 -7.83E7 -1.34 -0.8984 -0.6697 1627479 TimTec1_001809 Clc1ccc2occ(c3nc4ccccc4[nH]3)c(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C06 compound treatment 1.54285976E8 -1320000.0 -0.02 5.7070631E7 -9.12E7 -1.56 -1.1157 -0.7145 1585678 TimTec1_001810 CCCC(Nc1cc(Cl)cc(Cl)c1)n2nnc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C07 compound treatment 1.81931054E8 2.63E7 0.33 7.2269849E7 -7.6E7 -1.3 -0.6865 -0.5114 1693611 TimTec1_001811 COc1cc2ccc(=O)oc2c(O)c1OCC=C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C08 compound treatment 1.74578225E8 1.9E7 0.24 5.4579499E7 -9.37E7 -1.6 -0.9659 -0.5956 1333990 TimTec1_001812 COc1c2COC(=O)c2c(CSc3nnnn3c4ccccc4)c(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C09 compound treatment 8.6761258E7 -6.88E7 -0.86 3.3120802E7 -1.15E8 -1.97 -2.0046 -0.9314 1282090 TimTec1_001813 COc1cc2ccc(=O)oc2c(OC(=O)C)c1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C10 compound treatment 1.4245114E8 -1.32E7 -0.16 6.2433091E7 -8.58E7 -1.47 -1.1558 -0.7816 1488752 TimTec1_001814 O=C(CSc1nnnn1Cc2ccccc2)Nc3ccccc3Oc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C11 compound treatment 1.46528155E8 -9070000.0 -0.11 7.6517403E7 -7.18E7 -1.23 -0.9491 -0.7693 3083144 TimTec1_001815 Cc1ccc(cc1)C(=O)Oc2ccc(cc2)C3SCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C12 compound treatment 1.59592923E8 3990000.0 0.05 8.5557581E7 -6.27E7 -1.07 -0.7238 -0.6734 1118830 TimTec1_001816 CCc1ccc(OCC(=O)Nc2nnc[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C13 compound treatment 1.42221406E8 -1.34E7 -0.17 8.1384157E7 -6.69E7 -1.15 -0.9284 -0.8022 1376257 TimTec1_001817 OC(=O)C1CCCCC1C(=O)Nc2ccc3OCCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C14 compound treatment 1.43087025E8 -1.25E7 -0.16 8.3101963E7 -6.52E7 -1.12 -0.9 -0.7987 1783811 TimTec1_001818 CCCc1cc(=O)nc(SCC(=O)N)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C15 compound treatment 1.53610562E8 -1990000.0 -0.02 8.0748809E7 -6.75E7 -1.16 -0.8351 -0.7222 1028427 TimTec1_001819 NC(Cc1ccccc1F)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C16 compound treatment 1.49192628E8 -6410000.0 -0.08 8.1396041E7 -6.69E7 -1.14 -0.8664 -0.7549 1545473 TimTec1_001820 COc1ccccc1OCc2ccc(o2)C(=O)NCC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C17 compound treatment 1.45920453E8 -9680000.0 -0.12 8.947044E7 -5.88E7 -1.01 -0.7977 -0.7867 3209231 TimTec1_001821 O=C1C2NN=CC2C(=O)N1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C18 compound treatment 1.45850985E8 -9750000.0 -0.12 9.7858048E7 -5.04E7 -0.86 -0.6968 -0.7993 1165247 TimTec1_001822 CC1Cc2ccccc2N1C(=O)Nc3ccc(Cl)c(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C19 compound treatment 1.44561512E8 -1.1E7 -0.14 9.9022579E7 -4.93E7 -0.84 -0.6942 -0.8124 1627796 TimTec1_001823 COC(=O)c1ccc(CN2CCN(CC2)c3ccccc3OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C20 compound treatment 1.53991757E8 -1610000.0 -0.02 1.05314738E8 -4.3E7 -0.74 -0.5344 -0.7263 1491738 TimTec1_001824 O=C(N1CCOCC1)c2ccc(CSc3ncccn3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C21 compound treatment 1.43889173E8 -1.17E7 -0.15 8.3260264E7 -6.5E7 -1.11 -0.8909 -0.7936 3209232 TimTec1_001825 CN(C)c1ccc(/C=C/C(=O)C(=C2SCCS2)C(=O)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C22 compound treatment 1.62278955E8 6680000.0 0.08 9.6257543E7 -5.2E7 -0.89 -0.5705 -0.6378 3083151 TimTec1_001826 CCN(CC)S(=O)(=O)c1ccccc1/C=N/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C23 mock treatment 1.52707072E8 -2900000.0 -0.04 8.7191367E7 -6.11E7 -1.05 -0.7651 -0.7312 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 C24 mock treatment 1.73446055E8 1.78E7 0.22 1.006719E8 -4.76E7 -0.81 -0.418 -0.4946 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D01 compound treatment 7.3936825E7 -8.17E7 -1.02 9.0858052E7 -5.74E7 -0.98 -1.4195 -0.9998 3209233 TimTec1_001827 CC(Oc1ccc(C)cc1)n2ccc3CCCCc32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D02 compound treatment 7.2558322E7 -8.3E7 -1.04 9.7680043E7 -5.06E7 -0.87 -1.3491 -0.9958 1189402 TimTec1_001828 CN(C)CCCN1C(C(=C(O)C1=O)C(=O)c2cccs2)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D03 compound treatment 4.5266026E7 -1.1E8 -1.38 1.50377538E8 2100000.0 0.04 -0.9533 -0.6885 1710381 TimTec1_001829 Cc1ccc(cc1)S(=O)(=O)C(CC=C)c2cc(Cl)ccc2N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D04 compound treatment 6.6800822E7 -8.88E7 -1.11 9.2966632E7 -5.53E7 -0.95 -1.4572 -0.9967 3209234 TimTec1_001830 Cc1ccc2nc(NCc3cccnc3)c(/C=N/Cc4cccnc4)c(=O)n2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D05 compound treatment 6.0356521E7 -9.52E7 -1.19 1.00936459E8 -4.73E7 -0.81 -1.4179 -0.9821 1327331 TimTec1_001831 O=C1N(C(=O)c2ccccc12)c3ccc(C#N)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D06 compound treatment 6.0275472E7 -9.53E7 -1.2 6.3850937E7 -8.44E7 -1.45 -1.8675 -0.9956 1663256 TimTec1_001832 CCc1c(C)sc(NC(=O)c2cccs2)c1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D07 compound treatment 6.1909796E7 -9.37E7 -1.18 9.6001346E7 -5.23E7 -0.89 -1.4639 -0.991 3209235 TimTec1_001833 CC(=O)/N=C/1\NC(=O)\C(=C\c2ccc(o2)c3ccc4C(=O)OCc4c3)\S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D08 compound treatment 7.3318196E7 -8.23E7 -1.03 1.0432498E8 -4.4E7 -0.75 -1.2619 -0.9879 1576966 TimTec1_001834 CCOc1ccc2nc3c(=O)[nH]c(=O)nc3[nH]c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D09 compound treatment 7.2775427E7 -8.28E7 -1.04 1.62168632E8 1.39E7 0.24 -0.5666 -0.5316 3209236 TimTec1_001835 CC1(C)COC(=N1)/C=C(\O)/c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D10 compound treatment 6.7767922E7 -8.78E7 -1.1 9.704508E7 -5.12E7 -0.88 -1.3993 -0.9936 3082165 TimTec1_001836 Cc1ccc(cc1)/C(=N/O)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D11 compound treatment 7.1317178E7 -8.43E7 -1.06 9.3025724E7 -5.53E7 -0.95 -1.4165 -0.9985 1734335 TimTec1_001837 Cc1cccc(c1)N2CCN(CC(O)CN3C(=O)c4ccccc4C3=O)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D12 compound treatment 6.5429729E7 -9.02E7 -1.13 8.5651716E7 -6.26E7 -1.07 -1.5579 -0.9996 1573706 TimTec1_001838 Clc1cccc2cccc(c12)S(=O)(=O)Nc3ccc(OCC(=O)N4CCOCC4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D13 compound treatment 7.3529491E7 -8.21E7 -1.03 1.16296434E8 -3.2E7 -0.55 -1.1152 -0.9563 1609998 TimTec1_001839 CN(C)CCCn1c(N)c(c2nc3ccccc3[nH]2)c4nc(C#N)c(C#N)nc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D14 compound treatment 1.48350931E8 -7250000.0 -0.09 8.8525902E7 -5.98E7 -1.02 -0.7876 -0.767 3082168 TimTec1_001840 Clc1cc(C#N)ccc1CSc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D15 compound treatment 1.53838762E8 -1760000.0 -0.02 9.0820873E7 -5.75E7 -0.98 -0.7111 -0.7228 1310660 TimTec1_001841 OC(=O)c1ccc(cc1)C2SCC(=O)N2NS(=O)(=O)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D16 compound treatment 1.24380174E8 -3.12E7 -0.39 1.05069214E8 -4.32E7 -0.74 -0.8 -0.9558 1357681 TimTec1_001842 Nn1c(SCc2ccc(F)c3ccccc23)nc4ccccc4c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D17 compound treatment 1.62794111E8 7190000.0 0.09 8.8210566E7 -6.01E7 -1.03 -0.6633 -0.6426 3082170 TimTec1_001843 CN(C)c1ccc(cc1)C2=NN(CC2NC(Cc3c[nH]cn3)C(=O)O)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D18 compound treatment 1.53640613E8 -1960000.0 -0.02 1.05986815E8 -4.23E7 -0.72 -0.5293 -0.7307 1273745 TimTec1_001844 O=C(N1CCCc2ccccc12)c3ccccc3SCc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D19 compound treatment 1.4813904E8 -7460000.0 -0.09 1.11996879E8 -3.63E7 -0.62 -0.5054 -0.8046 3209237 TimTec1_001845 COc1cc(C)nc(NC(=O)NS(=O)(=O)c2ccccc2NC(=O)C(F)(F)F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D20 compound treatment 1.00504494E8 -5.51E7 -0.69 7.6558708E7 -7.17E7 -1.23 -1.3569 -0.9631 3082173 TimTec1_001846 CC(O)C(O)C(O)C(O)C1NN=C(S1)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D21 compound treatment 1.8073996E8 2.51E7 0.32 9.2334716E7 -5.59E7 -0.96 -0.4542 -0.4505 3209358 TimTec1_001847 C(Oc1ccccc1)C2CO/C(=N\c3ccccc3)/S2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D22 compound treatment 1.67485009E8 1.19E7 0.15 1.07234886E8 -4.1E7 -0.7 -0.3914 -0.545 1506008 TimTec1_001848 O=C(COc1ccccc1)N2CCN(CC2)C(=O)COc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D23 mock treatment 1.64052795E8 8450000.0 0.11 9.6403764E7 -5.19E7 -0.89 -0.553 -0.6183 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 D24 mock treatment 1.638224E8 8220000.0 0.1 1.09933916E8 -3.83E7 -0.66 -0.3912 -0.5888 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E01 compound treatment 3.9758233E7 -1.16E8 -1.45 1.30022169E8 -1.83E7 -0.31 -1.2486 -0.84 1600927 TimTec1_001849 OC(=O)C1CCCN1C(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E02 compound treatment 8.2469631E7 -7.31E7 -0.92 1.39198877E8 -9080000.0 -0.16 -0.7586 -0.8153 3209359 TimTec1_001850 CS/C(=N/CC=C)/N1CCN(CC1)\C(=N/CC=C)\SC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E03 compound treatment 1.01956246E8 -5.36E7 -0.67 1.34519177E8 -1.38E7 -0.24 -0.6424 -0.901 1599515 TimTec1_001851 C(N1CCN(Cc2cccs2)C1c3cccs3)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E04 compound treatment 1.15677355E8 -3.99E7 -0.5 1.32821259E8 -1.55E7 -0.26 -0.5413 -0.9555 3209360 TimTec1_001852 C=CCc1nc2ccccc2c(=O)n1CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E05 compound treatment 1.25073438E8 -3.05E7 -0.38 1.39816854E8 -8460000.0 -0.14 -0.3732 -0.9116 1613532 TimTec1_001853 Oc1ccc(Cl)cc1C(=O)c2cnc-3c(COc4ccccc43)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E06 compound treatment 1.27507492E8 -2.81E7 -0.35 1.44664515E8 -3620000.0 -0.06 -0.293 -0.8188 3082178 TimTec1_001854 N#C/C(=C/c1cccc2ccccc12)/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E07 compound treatment 9.9914905E7 -5.57E7 -0.7 1.35391766E8 -1.29E7 -0.22 -0.65 -0.8872 1314321 TimTec1_001855 COC1C2C=COC2=Nc3c(OC)cccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E08 compound treatment 1.25194527E8 -3.04E7 -0.38 1.46740696E8 -1540000.0 -0.03 -0.2884 -0.7542 3082180 TimTec1_001856 CCCCc1cc(CCCC)n2nc(cc2n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E09 compound treatment 1.21903555E8 -3.37E7 -0.42 1.28968658E8 -1.93E7 -0.33 -0.5327 -0.9926 1232294 TimTec1_001857 COc1cc2OCc3oc4c5CC(Oc5ccc4c(=O)c3-c2cc1OC)C(=C)CO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E10 compound treatment 1.14281929E8 -4.13E7 -0.52 1.32796827E8 -1.55E7 -0.27 -0.5539 -0.9515 1242147 TimTec1_001858 SC1=NN(C2=C(CCC2)S1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E11 compound treatment 1.15821298E8 -3.98E7 -0.5 1.32153304E8 -1.61E7 -0.28 -0.5481 -0.961 1647435 TimTec1_001859 CCSc1nnc(NC(=O)C2CC=CCC2C(=O)O)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E12 compound treatment 1.11965532E8 -4.36E7 -0.55 1.56896293E8 8620000.0 0.15 -0.2828 -0.4988 1075403 TimTec1_001860 OC(=O)CCCSc1nc2ccccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E13 compound treatment 1.0763571E8 -4.8E7 -0.6 1.44769444E8 -3510000.0 -0.06 -0.468 -0.7739 3082203 TimTec1_001861 CCOC(=O)c1c(NS(=O)(=O)c2ccc(Br)cc2)sc3CC(C)CCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E14 compound treatment 1.26542666E8 -2.91E7 -0.36 1.51410899E8 3130000.0 0.05 -0.2199 -0.5968 3082205 TimTec1_001862 Cc1ccn(n1)C(=S)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E15 compound treatment 1.25770133E8 -2.98E7 -0.37 1.40574578E8 -7710000.0 -0.13 -0.3579 -0.902 1913414 TimTec1_001863 NC(=O)CSc1nnnn1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E16 compound treatment 1.22982648E8 -3.26E7 -0.41 1.44908288E8 -3370000.0 -0.06 -0.3302 -0.7989 1534949 TimTec1_001864 CC(C)CNC(=O)c1ccc(COc2ccc3ccccc3c2)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E17 compound treatment 1.23898617E8 -3.17E7 -0.4 1.58649444E8 1.04E7 0.18 -0.1557 -0.3575 1920302 TimTec1_001865 Cc1sc2ncnc(SCC(=O)O)c2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E18 compound treatment 1.27351742E8 -2.83E7 -0.35 1.53316836E8 5040000.0 0.09 -0.1896 -0.5199 1565212 TimTec1_001866 CCN(CC)C(=O)c1ccc(COc2ccccc2Cl)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E19 compound treatment 1.20195241E8 -3.54E7 -0.44 1.6308897E8 1.48E7 0.25 -0.1348 -0.2636 3082210 TimTec1_001867 CCOc1cccc(/C=C/2\SC(=S)N(CC)C2=O)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E20 compound treatment 1.48327458E8 -7270000.0 -0.09 1.86328617E8 3.8E7 0.65 0.396 0.6021 1608939 TimTec1_001868 O=C(N1CCOCC1)c2ccc(CSc3cccc4cccnc34)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E21 compound treatment 1.26294495E8 -2.93E7 -0.37 1.01160968E8 -4.71E7 -0.81 -0.8303 -0.9367 3082212 TimTec1_001869 Cc1cc(no1)N2C(=O)CCC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E22 compound treatment 1.26708223E8 -2.89E7 -0.36 1.40523474E8 -7760000.0 -0.13 -0.3502 -0.9072 3082214 TimTec1_001870 CN(Cc1ccccc1)S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E23 mock treatment 1.31575819E8 -2.4E7 -0.3 1.63320466E8 1.5E7 0.26 -0.0311 -0.0784 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 E24 mock treatment 1.32932266E8 -2.27E7 -0.28 1.53988982E8 5710000.0 0.1 -0.132 -0.439 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F01 compound treatment 1.48092492E8 -7510000.0 -0.09 1.2013886E8 -2.81E7 -0.48 -0.4072 -0.8297 1506581 TimTec1_001871 CCCc1cc(=S)sc(N)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F02 compound treatment 1.60577581E8 4980000.0 0.06 1.26674119E8 -2.16E7 -0.37 -0.2174 -0.5796 1696777 TimTec1_001872 Cc1c(oc2ccccc12)C(=O)NC3CCS(=O)(=O)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F03 compound treatment 1.65095245E8 9490000.0 0.12 1.32485505E8 -1.58E7 -0.27 -0.107 -0.3621 1274289 TimTec1_001873 COc1ccc(NC=O)c(CS(=O)(=O)c2ccc(C)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F04 compound treatment 1.66047412E8 1.04E7 0.13 1.6919348E8 2.09E7 0.36 0.3458 0.9071 3209361 TimTec1_001874 CC(C)(C)c1ccc(/C=C/C(=O)NC2CCS(=O)(=O)C2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F05 compound treatment 1.65876915E8 1.03E7 0.13 1.31949416E8 -1.63E7 -0.28 -0.1065 -0.3461 3082218 TimTec1_001875 OC(=O)/C=C/C(=O)NN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F06 compound treatment 1.5915103E8 3550000.0 0.04 1.68123892E8 1.98E7 0.34 0.2717 0.793 1130638 TimTec1_001876 CC1(C)Cc2ccccc2-c3nc(SCC(=O)c4ccccc4)n(CC=C)c(=O)c31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F07 compound treatment 1.62705353E8 7100000.0 0.09 1.25617161E8 -2.27E7 -0.39 -0.2113 -0.5309 1779186 TimTec1_001877 CC(C)COC(=O)C(C)Nc1n[nH]c(=S)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F08 compound treatment 1.53378693E8 -2220000.0 -0.03 1.34670222E8 -1.36E7 -0.23 -0.1845 -0.7862 3209362 TimTec1_001878 O=C/1NC(=S)S\C1=C/C=C/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F09 compound treatment 1.00366836E8 -5.52E7 -0.69 1.21223568E8 -2.71E7 -0.46 -0.8175 -0.9808 3209363 TimTec1_001879 CC(C)(C)c1ccc(/C=C/2\CCCC(=C3SCCCS3)C2=O)c4OCOc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F10 compound treatment 1.67071931E8 1.15E7 0.14 1.82541421E8 3.43E7 0.59 0.5164 0.8552 3082222 TimTec1_001880 CN1CC=C2[C@@H](C1)[C@H](c3ccncc3)C(C#N)(C#N)C(=C2C(=O)O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F11 compound treatment 8.4667866E7 -7.09E7 -0.89 3.9593991E7 -1.09E8 -1.86 -1.9448 -0.943 1653015 TimTec1_001881 OC12OCCN(C2=CC(=O)c3ccccc31)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F12 compound treatment 1.68524656E8 1.29E7 0.16 2.01966904E8 5.37E7 0.92 0.7645 0.8192 3082224 TimTec1_001882 Cn1cnnc1SCc2ccc(cc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F13 compound treatment 1.5378969E8 -1810000.0 -0.02 1.30131093E8 -1.81E7 -0.31 -0.2358 -0.7568 3209364 TimTec1_001883 Cc1ccc(cc1)C(=O)OC2CSC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F14 compound treatment 1.14720529E8 -4.09E7 -0.51 1.87256142E8 3.9E7 0.67 0.1091 0.1297 1312775 TimTec1_001884 COc1cc(NC(=O)c2ccc(CSC3CCCCC3)cc2)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F15 compound treatment 1.07170321E8 -4.84E7 -0.61 1.27529958E8 -2.08E7 -0.36 -0.6808 -0.9673 3082227 TimTec1_001885 Fc1ccc(cc1Cl)C2=NNC3(C2)C(=O)Nc4ccccc43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F16 compound treatment 1.6447603E8 8870000.0 0.11 1.18497694E8 -2.98E7 -0.51 -0.2818 -0.54 1110868 TimTec1_001886 CC(C)(Oc1ccc(Br)cc1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F17 compound treatment 1.49763303E8 -5840000.0 -0.07 1.43283977E8 -5000000.0 -0.09 -0.1123 -0.997 3209365 TimTec1_001887 CCCC(=O)c1ccc2=Sc3ccccc3N(=c2c1)CCCN(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F18 compound treatment 1.59515723E8 3910000.0 0.05 1.8747398E8 3.92E7 0.67 0.5091 0.7568 3082260 TimTec1_001888 O=C(NCCOc1ccccc1c2ccccc2)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F19 compound treatment 1.47960594E8 -7640000.0 -0.1 1.89344679E8 4.11E7 0.7 0.4293 0.6051 3082232 TimTec1_001889 CCSc1nnc([nH]1)c2c(Cl)c(CC)nn2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F20 compound treatment 1.6652108E8 1.09E7 0.14 1.6544704E8 1.72E7 0.29 0.3046 0.9396 3082235 TimTec1_001890 Fc1ccc(cc1)C(=O)CCCSc2nc3ccc(Cl)cc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F21 compound treatment 1.50354148E8 -5250000.0 -0.07 1.86748041E8 3.85E7 0.66 0.4191 0.6333 1676324 TimTec1_001891 CC1=Nc2ccccc2N(CC(O)Cn3c4ccccc4c5ccccc35)C(=O)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F22 compound treatment 1.53217764E8 -2380000.0 -0.03 1.71337356E8 2.31E7 0.39 0.2579 0.6516 3082237 TimTec1_001892 CSc1nc2CCCCCc2cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F23 mock treatment 1.44586202E8 -1.1E7 -0.14 1.34621299E8 -1.37E7 -0.23 -0.2631 -0.9685 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 F24 mock treatment 1.28765386E8 -2.68E7 -0.34 1.22209995E8 -2.61E7 -0.45 -0.5536 -0.9903 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G01 compound treatment 5.0083154E7 -1.06E8 -1.32 1.21460273E8 -2.68E7 -0.46 -1.2606 -0.8998 3082238 TimTec1_001893 NC(=O)CSc1nc(ccc1C#N)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G02 compound treatment 9.5142191E7 -6.05E7 -0.76 8.0258476E7 -6.8E7 -1.16 -1.3597 -0.9784 3209366 TimTec1_001894 Ic1ccc(/C=C/2\SC(=N)NC2=O)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G03 compound treatment 1.08767504E8 -4.68E7 -0.59 8.6214054E7 -6.21E7 -1.06 -1.1667 -0.961 3082240 TimTec1_001895 CN(Cc1cccs1)C(=S)SCc2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G04 compound treatment 1.11920267E8 -4.37E7 -0.55 1.1290141E8 -3.54E7 -0.61 -0.8157 -0.9988 3209367 TimTec1_001896 NC(=O)Cn1nnc(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G05 compound treatment 1.02440445E8 -5.32E7 -0.67 6.1322891E7 -8.7E7 -1.49 -1.5241 -0.9344 3209368 TimTec1_001897 OC(=O)c1ccccc1c2ccc(/C=N/N3C(=O)C4C5CC(C=C5)C4C3=O)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G06 compound treatment 1.1852884E8 -3.71E7 -0.47 7.8242529E7 -7.0E7 -1.2 -1.1766 -0.915 1473623 TimTec1_001898 CCCCC1(CC(=O)N2CCOCC2)C(=O)N(N(C1=O)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G07 compound treatment 1.06355086E8 -4.92E7 -0.62 1.00237086E8 -4.8E7 -0.82 -1.0184 -0.9901 3209369 TimTec1_001899 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G08 compound treatment 3.2194773E7 -1.23E8 -1.55 9378966.0 -1.39E8 -2.38 -2.776 -0.9784 1265525 TimTec1_001900 Cc1cc(=O)n2nc(nc2[nH]1)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G09 compound treatment 1.37103449E8 -1.85E7 -0.23 8.525228E7 -6.3E7 -1.08 -0.927 -0.84 3209370 TimTec1_001901 CC(C)C(O)(C(C)O)C(=O)OC[C@@H]1CCN2CCC[C@@H]12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G10 compound treatment 1.3640116E8 -1.92E7 -0.24 1.27610374E8 -2.07E7 -0.35 -0.4205 -0.9824 3082244 TimTec1_001902 Sc1nnc(Cc2cccc3ccccc23)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G11 compound treatment 1.31460204E8 -2.41E7 -0.3 1.54859571E8 6580000.0 0.11 -0.1345 -0.4163 3209371 TimTec1_001903 OC(=O)C1C(C2CC1C=C2)C(=O)Nc3nc4ccc(Br)cc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G12 compound treatment 1.46664E8 -8940000.0 -0.11 1.59110157E8 1.08E7 0.19 0.0518 0.2391 1779185 TimTec1_001904 CC(C)OC(=O)C(C)Nc1n[nH]c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G13 compound treatment 1.34815791E8 -2.08E7 -0.26 1.19845375E8 -2.84E7 -0.49 -0.5286 -0.9572 3082246 TimTec1_001905 Cc1cc(C)n(n1)C(=O)CSc2nc(C)c(C)cc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G14 compound treatment 1.42764384E8 -1.28E7 -0.16 1.07620417E8 -4.07E7 -0.7 -0.606 -0.8483 1137282 TimTec1_001906 O=C(Nc1ccccc1)c2ccn(n2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G15 compound treatment 1.5009128E8 -5510000.0 -0.07 1.60198165E8 1.19E7 0.2 0.0954 0.4427 3209372 TimTec1_001907 Cc1cc(NC(=O)C(F)(F)F)n(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G16 compound treatment 1.18981501E8 -3.66E7 -0.46 1.33991352E8 -1.43E7 -0.24 -0.4978 -0.9565 1200660 TimTec1_001908 CN(C1CCCCC1)C(=O)c2ccc(COc3ccc(C)c(C)c3)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G17 compound treatment 1.35051116E8 -2.06E7 -0.26 1.24620875E8 -2.37E7 -0.41 -0.4687 -0.9762 1113186 TimTec1_001909 Brc1ccc2noc(c3ccccc3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G18 compound treatment 1.25634585E8 -3.0E7 -0.38 8.1591886E7 -6.67E7 -1.14 -1.073 -0.8928 1294501 TimTec1_001910 CN(C(=O)c1ccc(COc2ccccc2Cl)o1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G19 compound treatment 1.31947412E8 -2.37E7 -0.3 1.07624949E8 -4.07E7 -0.7 -0.7019 -0.9278 3209491 TimTec1_001911 COC(=O)C1=CO[C@H](C)[C@@H]2CN3CCC4(C3C[C@@H]21)C(=O)Nc5ccccc54 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G20 compound treatment 1.49919593E8 -5680000.0 -0.07 1.03502246E8 -4.48E7 -0.77 -0.5924 -0.7695 1332425 TimTec1_001912 Cc1nnc(SCc2ccc(cc2)C(=O)N3CCOCC3)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G21 compound treatment 1.53450946E8 -2150000.0 -0.03 1.79787744E8 3.15E7 0.54 0.3623 0.6709 1920052 TimTec1_001913 OC(=O)/C=C/C(=O)NCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G22 compound treatment 1.47616724E8 -7990000.0 -0.1 1.81176215E8 3.29E7 0.56 0.3273 0.5723 1403707 TimTec1_001914 CC(C)(C)S(=O)(=O)c1cccc(c1)S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G23 mock treatment 1.42130917E8 -1.35E7 -0.17 5.383875E7 -9.44E7 -1.62 -1.2626 -0.7768 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 G24 mock treatment 1.50231644E8 -5370000.0 -0.07 2.5939047E7 -1.22E8 -2.09 -1.5285 -0.7295 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H01 compound treatment 1.33602651E8 -2.2E7 -0.28 1.36231089E8 -1.2E7 -0.21 -0.341 -0.9897 3209492 TimTec1_001915 CCOC(C)n1cccc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H02 compound treatment 1.31673603E8 -2.39E7 -0.3 8.6767976E7 -6.15E7 -1.05 -0.9568 -0.8739 1257360 TimTec1_001916 CC(C)Cc1nc(C#N)c(NCC=C)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H03 compound treatment 1.60841544E8 5240000.0 0.07 8.7380832E7 -6.09E7 -1.04 -0.6907 -0.6612 1616013 TimTec1_001917 Cc1ccc(cc1)S(=O)(=O)c2n[nH]c3ccc(Cl)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H04 compound treatment 1.37700641E8 -1.79E7 -0.22 8.4419234E7 -6.39E7 -1.09 -0.9318 -0.8349 1492803 TimTec1_001918 CC(C)OC(=O)C1=C(C)NC(=O)NC1C2CCC=CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H05 compound treatment 8.7710097E7 -6.79E7 -0.85 8.1472252E7 -6.68E7 -1.14 -1.4109 -0.9895 3082254 TimTec1_001919 NC(=N)NS(=O)(=O)c1ccc(NC(=O)/C=C/C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H06 compound treatment 9.3724417E7 -6.19E7 -0.78 8.8164146E7 -6.01E7 -1.03 -1.2765 -0.9903 3209493 TimTec1_001920 FC(F)(F)c1cccc(NC(=O)Cn2ccc3ccccc23)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H07 compound treatment 1.15184101E8 -4.04E7 -0.51 8.518453E7 -6.31E7 -1.08 -1.1223 -0.9406 3082255 TimTec1_001921 CSc1nnc(C)c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H08 compound treatment 1.18479649E8 -3.71E7 -0.47 7.8212761E7 -7.01E7 -1.2 -1.1774 -0.9151 1174278 TimTec1_001922 COc1ccc(cc1)C(=O)Nc2cccc(c2)c3nc4ccccc4s3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H09 compound treatment 1.40308498E8 -1.53E7 -0.19 8.2281073E7 -6.6E7 -1.13 -0.9345 -0.8155 1288259 TimTec1_001923 Cn1nc(CC(=O)NN)c2ccccc2c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H10 compound treatment 1.15043234E8 -4.06E7 -0.51 8.3938799E7 -6.43E7 -1.1 -1.1386 -0.9385 1396336 TimTec1_001924 COc1ccc(Cl)cc1C(=O)N2CCCC2C(=O)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H11 compound treatment 2.35667007E8 8.01E7 1.0 1.97375473E8 4.91E7 0.84 1.3045 0.9961 1259025 TimTec1_001925 COc1ccc(cc1)c2cc(nc(NC(=S)N)n2)c3ccccc3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H12 compound treatment 1.39093641E8 -1.65E7 -0.21 8.4461713E7 -6.38E7 -1.09 -0.9189 -0.8264 3209494 TimTec1_001926 CSc1ccccc1C(=O)NCCOc2ccccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H13 compound treatment 1.19210592E8 -3.64E7 -0.46 7.1556043E7 -7.67E7 -1.31 -1.2515 -0.9001 3082265 TimTec1_001927 O=C(OC1CSC1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H14 compound treatment 1.23974842E8 -3.16E7 -0.4 6.8965731E7 -7.93E7 -1.36 -1.2406 -0.8771 1610378 TimTec1_001928 CCS(=O)(=O)Nc1ccc(Br)cn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H15 compound treatment 8.4006907E7 -7.16E7 -0.9 6.4156556E7 -8.41E7 -1.44 -1.6533 -0.9742 1433512 TimTec1_001929 COc1ccc2cc(C3SC(C)C(=O)N3C4CCCO4)c(Cl)nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H16 compound treatment 1.59071659E8 3470000.0 0.04 5.477806E7 -9.35E7 -1.6 -1.101 -0.6876 1347404 TimTec1_001930 CN1C(=O)N(C)C(=O)C(CCc2ccncc2)(C1=O)C3(CCCCC3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H17 compound treatment 1.72317055E8 1.67E7 0.21 1.22974959E8 -2.53E7 -0.43 -0.158 -0.3284 1631720 TimTec1_001931 Cc1ccc(cc1)C2C=C(NC(=O)C2C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H18 compound treatment 1.55019211E8 -583000.0 -0.01 6.0024357E7 -8.83E7 -1.51 -1.0734 -0.7105 3082269 TimTec1_001932 CS(=O)(=O)c1nc(n[nH]1)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H19 compound treatment 1.04052453E8 -5.15E7 -0.65 3.7919037E7 -1.1E8 -1.89 -1.7931 -0.898 1458072 TimTec1_001933 C1OC(OCc2nonc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H20 compound treatment 9.5798871E7 -5.98E7 -0.75 3.7662859E7 -1.11E8 -1.89 -1.8694 -0.9178 1288232 TimTec1_001934 CC(=C)CC(N)(CC(=C)C)c1ccncc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H21 compound treatment 9.8935397E7 -5.67E7 -0.71 3.0601528E7 -1.18E8 -2.01 -1.9271 -0.9021 1301124 TimTec1_001935 CSc1nsc(SC)c1NC(=O)OCC2CCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H22 compound treatment 1.58445438E8 2840000.0 0.04 2.6505364E7 -1.22E8 -2.08 -1.4488 -0.6949 3209495 TimTec1_001936 CC1CCN(CC1)S(=O)(=O)c2ccc(NC(=O)/C=C/c3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H23 mock treatment 1.5599518E8 393000.0 0.0 1.5071808E7 -1.33E8 -2.28 -1.6089 -0.7056 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 H24 mock treatment 1.47471798E8 -8130000.0 -0.1 2.0209503E7 -1.28E8 -2.19 -1.6223 -0.7392 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I01 compound treatment 5.1279492E7 -1.04E8 -1.31 1.71620438E8 2.33E7 0.4 -0.6429 -0.4698 1268779 TimTec1_001937 Cc1ccc2c(N)c(sc2n1)C(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I02 compound treatment 1.10629431E8 -4.5E7 -0.56 2.11582599E8 6.33E7 1.08 0.3673 0.3007 3209496 TimTec1_001938 Nc1sc(=S)n(c1c2nc3ccccc3s2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I03 compound treatment 9.5167922E7 -6.04E7 -0.76 1.63439766E8 1.52E7 0.26 -0.3526 -0.44 1735247 TimTec1_001939 Cc1ccc(cc1)N(c2ccc(C)cc2)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I04 compound treatment 1.01216621E8 -5.44E7 -0.68 1.84388819E8 3.61E7 0.62 -0.0454 -0.0493 1463202 TimTec1_001940 S=c1oc2ccccc2n1Cn3c(=S)oc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I05 compound treatment 1.17598709E8 -3.8E7 -0.48 2.08307403E8 6.0E7 1.03 0.3895 0.3438 1128826 TimTec1_001941 Cc1ccc(cc1C)N(Cc2ccc(cc2)C(=O)O)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I06 compound treatment 1.13387505E8 -4.22E7 -0.53 1.43257717E8 -5020000.0 -0.09 -0.4353 -0.8113 1310569 TimTec1_001942 O=C(CSc1nc2ccccc2nc1SCC(=O)N3CCCCC3)N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I07 compound treatment 1.49132592E8 -6470000.0 -0.08 1.95031515E8 4.68E7 0.8 0.5085 0.6322 1383182 TimTec1_001943 COc1cc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2cc1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I08 compound treatment 1.66305621E8 1.07E7 0.13 1.76481454E8 2.82E7 0.48 0.4363 0.8707 1574289 TimTec1_001944 CC(C)(C)NC(=O)CSc1nc2ccccc2nc1SCC(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I09 compound treatment 1.65430604E8 9830000.0 0.12 2.02747355E8 5.45E7 0.93 0.7465 0.7937 3209497 TimTec1_001945 COC(C)C(O)(C(C)C)C(=O)OC1=CCN2CC[C@H](O)[C@H]21 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I10 compound treatment 1.5779014E8 2190000.0 0.03 1.31473509E8 -1.68E7 -0.29 -0.184 -0.6368 1160311 TimTec1_001946 Cc1ccc(o1)C(=O)CSC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I11 compound treatment 1.84242829E8 2.86E7 0.36 1.56352194E8 8070000.0 0.14 0.3518 0.9138 1681019 TimTec1_001947 S=C(NC1CCCCC1)N2CCN(Cc3ccc4OCOc4c3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I12 compound treatment 2.00429994E8 4.48E7 0.56 1.80990927E8 3.27E7 0.56 0.7936 1.0 1315095 TimTec1_001948 Cc1nnc(NCCc2ccccc2)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I13 compound treatment 1.93924423E8 3.83E7 0.48 1.68703901E8 2.04E7 0.35 0.5871 0.9878 3209498 TimTec1_001949 CC1CCc2c(C#N)c(NC(=O)c3cc4nc(cc(n4n3)C(F)(F)F)c5ccccc5)sc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I14 compound treatment 1.88256413E8 3.27E7 0.41 1.56159081E8 7880000.0 0.13 0.385 0.8928 1544670 TimTec1_001950 CCOc1ccc(cc1)c2nc3ccc(Br)cc3c(C(=O)O)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I15 compound treatment 1.86281485E8 3.07E7 0.38 1.81346322E8 3.31E7 0.57 0.6724 0.9823 3209499 TimTec1_001951 Oc1ccc(cc1)c2nc3sc(nc3s2)c4ccc(O)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I16 compound treatment 1.7895005E8 2.33E7 0.29 1.56409531E8 8130000.0 0.14 0.3055 0.9421 1375855 TimTec1_001952 Clc1ccc(Cl)c(OCc2ccc(o2)C(=O)NC3CCCC3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I17 compound treatment 1.84934907E8 2.93E7 0.37 1.602256E8 1.19E7 0.2 0.4048 0.9616 1710780 TimTec1_001953 Cc1ccc(cc1)C(=O)OCC2OC3C(Oc4c(C)c(=O)ncn34)C2OC(=O)c5ccc(C)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I18 compound treatment 1.77933735E8 2.23E7 0.28 1.54134889E8 5850000.0 0.1 0.2689 0.904 1488850 TimTec1_001954 CC(C)c1ccc(OCc2ccc(o2)C(=O)N(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I19 compound treatment 2.05215193E8 4.96E7 0.62 1.93060425E8 4.48E7 0.77 0.9821 0.9947 3082282 TimTec1_001955 c1ccc(cc1)c2ccnc(c2)c3cc(ccn3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I20 compound treatment 1.88958854E8 3.34E7 0.42 1.60480807E8 1.22E7 0.21 0.4436 0.9485 3209500 TimTec1_001956 O=S(=O)(c1ccsc1)c2ccsc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I21 compound treatment 1.71657473E8 1.61E7 0.2 1.36053089E8 -1.22E7 -0.21 -0.0056 -0.0192 1577514 TimTec1_001957 CC1Oc2ccccc2C(=O)N1c3ccc(OC=C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I22 compound treatment 1.84121413E8 2.85E7 0.36 1.65011969E8 1.67E7 0.29 0.4555 0.9939 1686206 TimTec1_001958 CC(C)(C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I23 mock treatment 1.85554383E8 3.0E7 0.38 1.69885734E8 2.16E7 0.37 0.5272 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 I24 mock treatment 1.7489594E8 1.93E7 0.24 1.64163798E8 1.59E7 0.27 0.3634 0.9983 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J01 compound treatment 1.71147388E8 1.55E7 0.2 1.4341773E8 -4860000.0 -0.08 0.079 0.3727 3082285 TimTec1_001959 CC(C)OC(C)n1cccc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J02 compound treatment 1.81189364E8 2.56E7 0.32 1.41036096E8 -7240000.0 -0.12 0.1393 0.4048 1308224 TimTec1_001960 Cc1c(oc2ccccc12)C(=O)Nc3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J03 compound treatment 1.51408114E8 -4190000.0 -0.05 1.63169031E8 1.49E7 0.25 0.143 0.5495 1495070 TimTec1_001961 COc1ccccc1NCC(=O)n2nc(cc2c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J04 compound treatment 1.90308978E8 3.47E7 0.44 1.52537752E8 4260000.0 0.07 0.3594 0.8141 3209501 TimTec1_001962 Cc1ccc(cc1)S(=O)(=O)/C(=C/C2=Cc3ccccc3OC2)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J05 compound treatment 1.71621657E8 1.6E7 0.2 1.67700303E8 1.94E7 0.33 0.3772 0.9709 3082288 TimTec1_001963 Oc1cccc(/C=N/c2ccccc2C#N)c1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J06 compound treatment 1.95832174E8 4.02E7 0.5 1.79147568E8 3.09E7 0.53 0.7305 0.9997 1558299 TimTec1_001964 CCOc1ccc(NC(=O)CN2CCCc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J07 compound treatment 2.17029113E8 6.14E7 0.77 1.76585007E8 2.83E7 0.48 0.8875 0.975 1170983 TimTec1_001965 COC(=O)C(NC(=O)Nc1ccccc1)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J08 compound treatment 1.91589336E8 3.6E7 0.45 1.9231091E8 4.4E7 0.75 0.8522 0.97 1183270 TimTec1_001966 CC(C)CC(=O)Nc1cccc(c1)c2nc3cc(C)ccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J09 compound treatment 1.92434684E8 3.68E7 0.46 1.58250176E8 9970000.0 0.17 0.4474 0.9083 1047437 TimTec1_001967 CC(C(=O)O)(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J10 compound treatment 1.24444215E8 -3.12E7 -0.39 9.4685786E7 -5.36E7 -0.92 -0.9251 -0.9277 3209502 TimTec1_001968 CN1C(=O)/C(=C(/C#N)\C(=O)N)/c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J11 compound treatment 1.87677247E8 3.21E7 0.4 1.71297869E8 2.3E7 0.39 0.5631 0.9999 3082292 TimTec1_001969 CC1(O)CCOCC1NC(Cc2cc3ccccc3[nH]2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J12 compound treatment 1.71730992E8 1.61E7 0.2 1.78361831E8 3.01E7 0.51 0.5072 0.9167 3209503 TimTec1_001970 CN1C(=O)C2C=CC=CC2N=C1SCC(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J13 compound treatment 1.74864603E8 1.93E7 0.24 1.8834975E8 4.01E7 0.69 0.6559 0.9019 1534000 TimTec1_001971 O=C(c1nnn2CC(=O)OC3(CCCCC3)c12)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J14 compound treatment 1.75083154E8 1.95E7 0.24 1.39526612E8 -8750000.0 -0.15 0.0668 0.2332 3082295 TimTec1_001972 O=C(CSCc1ccccc1)Nc2ccccc2C(=O)NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J15 compound treatment 1.96809059E8 4.12E7 0.52 1.29759799E8 -1.85E7 -0.32 0.1413 0.2331 3209618 TimTec1_001973 OC(=O)CC(S/C(=N/C1CCCC=C1)/N2CCCCC2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J16 compound treatment 1.97563467E8 4.2E7 0.53 1.75840606E8 2.76E7 0.47 0.7058 0.9985 3209619 TimTec1_001974 CC(C)CCCN1C(=O)NC(=O)/C(=C\c2ccc[nH]2)/C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J17 compound treatment 2.11939529E8 5.63E7 0.71 1.86312664E8 3.8E7 0.65 0.9601 0.9992 3082297 TimTec1_001975 O=C(N/C(=C\c1cccnc1)/C(=O)N2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J18 compound treatment 1.9596066E8 4.04E7 0.51 1.76386796E8 2.81E7 0.48 0.6982 0.9997 1185980 TimTec1_001976 COc1cc(CNC(=O)c2ccccc2SC)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J19 compound treatment 1.91488946E8 3.59E7 0.45 1.60640563E8 1.24E7 0.21 0.4679 0.9407 3082299 TimTec1_001977 c1coc(c1)c2cc(on2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J20 compound treatment 1.65980911E8 1.04E7 0.13 1.20987475E8 -2.73E7 -0.47 -0.2383 -0.4913 3209620 TimTec1_001978 FC(F)(F)C(=O)Nc1sc2CCCCc2c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J21 compound treatment 1.92585374E8 3.7E7 0.46 1.63019608E8 1.47E7 0.25 0.5065 0.959 1168141 TimTec1_001979 Cc1cc(C)c(C#N)c(SCCN2CCCCC2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J22 compound treatment 1.87273092E8 3.17E7 0.4 1.58338171E8 1.01E7 0.17 0.4027 0.93 1235345 TimTec1_001980 O=C(NCCC1=CCCCC1)C(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J23 mock treatment 1.93822559E8 3.82E7 0.48 1.74814511E8 2.65E7 0.45 0.6602 0.9996 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 J24 mock treatment 1.67489468E8 1.19E7 0.15 1.55893449E8 7610000.0 0.13 0.1976 0.9977 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K01 compound treatment 4.0193862E7 -1.15E8 -1.45 1.49267331E8 987000.0 0.02 -1.0118 -0.6988 3209621 TimTec1_001981 Cc1nc2ccc(cc2n1CCc3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K02 compound treatment 1.09935216E8 -4.57E7 -0.57 1.64141545E8 1.59E7 0.27 -0.2131 -0.3361 3082327 TimTec1_001982 Cc1ccc2nc(NC(=O)OC(C)(C)C)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K03 compound treatment 8.9500623E7 -6.61E7 -0.83 1.72231161E8 2.4E7 0.41 -0.2964 -0.3205 1449100 TimTec1_001983 C[N+]1(Cc2ccccc2)CCCC1c3ccc(N)nc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K04 compound treatment 1.13463248E8 -4.21E7 -0.53 1.75942527E8 2.77E7 0.47 -0.039 -0.0549 3082329 TimTec1_001984 CC(=O)On1cc(F)c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K05 compound treatment 4.06812495E8 2.51E8 3.15 5.46551503E8 3.98E8 6.82 7.0491 0.9385 1405621 TimTec1_001985 Cc1cc2ccc(=O)oc2cc1OC[C@@H](O)C(C)(C)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K06 compound treatment 1.52801795E8 -2800000.0 -0.04 1.82484237E8 3.42E7 0.59 0.3892 0.6635 3082331 TimTec1_001986 Cn1c(S)ncc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K07 compound treatment 1.63486307E8 7880000.0 0.1 1.23877545E8 -2.44E7 -0.42 -0.2254 -0.5252 1398791 TimTec1_001987 CNCC(O)c1cccc(O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K08 compound treatment 1.76884265E8 2.13E7 0.27 2.00679252E8 5.24E7 0.9 0.823 0.8794 3209623 TimTec1_001988 COc1ccc(cc1)C2NN(CN3CCOCC3)C(=S)N2Cc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K09 compound treatment 1.58053352E8 2450000.0 0.03 1.68179771E8 1.99E7 0.34 0.2626 0.7678 1115322 TimTec1_001989 COc1ccn(C)c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K10 compound treatment 1.49272957E8 -6330000.0 -0.08 1.07382329E8 -4.09E7 -0.7 -0.5512 -0.7823 3082334 TimTec1_001990 CC1=C(C)N(N=C(S)S1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K11 compound treatment 1.54533414E8 -1070000.0 -0.01 1.30630023E8 -1.77E7 -0.3 -0.2231 -0.7378 3209624 TimTec1_001991 O=C(C1CCCO1)N2CCN(C/C=C/c3ccccc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K12 compound treatment 1.91908641E8 3.63E7 0.46 1.83918371E8 3.56E7 0.61 0.7534 0.9896 3082336 TimTec1_001992 CN(C)CCNc1nc(=O)[nH]nc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K13 compound treatment 1.44481784E8 -1.11E7 -0.14 1.60855862E8 1.26E7 0.22 0.0536 0.2088 1514990 TimTec1_001993 Clc1ccc(cc1)C(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K14 compound treatment 1.66709025E8 1.11E7 0.14 1.01294898E8 -4.7E7 -0.8 -0.4702 -0.576 3082338 TimTec1_001994 O/C=C\1/C(=O)NC(=O)N(C1=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K15 compound treatment 2.02675746E8 4.71E7 0.59 1.2339628E8 -2.49E7 -0.43 0.1164 0.1598 1598606 TimTec1_001995 CC(=O)Nc1nonc1NC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K16 compound treatment 1.74465001E8 1.89E7 0.24 1.71510605E8 2.32E7 0.4 0.4485 0.9693 1221200 TimTec1_001996 CC(C)CNC(=O)c1ccc(COc2cc(Cl)ccc2Cl)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K17 compound treatment 2.23873134E8 6.83E7 0.86 1.40732919E8 -7550000.0 -0.13 0.5142 0.5937 3209625 TimTec1_001997 CC(=O)OCC(=O)Nc1cc(Cl)cc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K18 compound treatment 1.99554405E8 4.4E7 0.55 1.61005862E8 1.27E7 0.22 0.5439 0.9175 1148960 TimTec1_001998 CCc1ccc(cc1)c2cc(C(=O)OC)c3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K19 compound treatment 1.82052007E8 2.64E7 0.33 8.8479605E7 -5.98E7 -1.02 -0.4892 -0.4546 3209626 TimTec1_001999 O=C(ON1C(=O)CCC1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K20 compound treatment 2.07265313E8 5.17E7 0.65 1.9313004E8 4.48E7 0.77 1.0011 0.9964 3082343 TimTec1_002000 CCOC(=O)CSc1nc(C)cs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K21 compound treatment 1.87175573E8 3.16E7 0.4 1.92633319E8 4.44E7 0.76 0.8169 0.954 3209627 TimTec1_002001 CC(NC(C(=O)O)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K22 compound treatment 1.81366173E8 2.58E7 0.32 1.24822211E8 -2.35E7 -0.4 -0.0554 -0.1075 1544248 TimTec1_002002 COc1cccc(NC(=O)COC(=O)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K23 mock treatment 1.69436481E8 1.38E7 0.17 1.26297075E8 -2.2E7 -0.38 -0.1434 -0.346 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 K24 mock treatment 1.8511482E8 2.95E7 0.37 1.49897954E8 1620000.0 0.03 0.2814 0.7579 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L01 compound treatment 1.40727977E8 -1.49E7 -0.19 1.45318699E8 -2960000.0 -0.05 -0.1678 -0.8678 3209628 TimTec1_002003 CC(C)(O)/C(=C/C#N)/n1cccn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L02 compound treatment 1.35847379E8 -1.98E7 -0.25 9.4420114E7 -5.39E7 -0.92 -0.8272 -0.8664 3209629 TimTec1_002004 COc1ccc(OCC(=O)Sc2ccc(Cl)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L03 compound treatment 1.2339077E8 -3.22E7 -0.4 1.03307913E8 -4.5E7 -0.77 -0.8301 -0.9547 3082347 TimTec1_002005 O=C(/C=C/c1ccccc1)N2CCN(Cc3ccccc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L04 compound treatment 1.1175188E8 -4.39E7 -0.55 1.05929053E8 -4.24E7 -0.72 -0.9016 -0.9907 1118669 TimTec1_002006 COc1cccc(c1)C(CC(=O)c2ccc(Cl)cc2)C(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L05 compound treatment 1.83446651E8 2.78E7 0.35 1.53545366E8 5260000.0 0.09 0.3107 0.8613 3082349 TimTec1_002007 CC(C)OC(=O)C(C)/N=C/c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L06 compound treatment 1.34736526E8 -2.09E7 -0.26 1.13762421E8 -3.45E7 -0.59 -0.6029 -0.9329 3209630 TimTec1_002008 Clc1ccc(SC(CC(=O)C2CC2)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L07 compound treatment 1.28435684E8 -2.72E7 -0.34 1.04452673E8 -4.38E7 -0.75 -0.7715 -0.9362 1021708 TimTec1_002009 c1ccc(cc1)c2nc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L08 compound treatment 1.34448372E8 -2.12E7 -0.27 1.18156998E8 -3.01E7 -0.52 -0.5523 -0.9523 3209631 TimTec1_002010 COC(=O)c1c(N/C=C/2\C(=O)NC(=O)N(Cc3ccccc3)C2=O)sc4CCCCc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L09 compound treatment 1.24941494E8 -3.07E7 -0.38 1.04464536E8 -4.38E7 -0.75 -0.8023 -0.9519 1168270 TimTec1_002011 CCN(CC)c1ncn(Cc2c(Cl)cccc2Cl)c3ncnc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L10 compound treatment 1.32618641E8 -2.3E7 -0.29 1.07222504E8 -4.11E7 -0.7 -0.7008 -0.9226 3209632 TimTec1_002012 COc1ccccc1OCCNC(=O)c2ccc(cc2)S(=O)(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L11 compound treatment 1.35613953E8 -2.0E7 -0.25 1.12961349E8 -3.53E7 -0.6 -0.6048 -0.924 3082356 TimTec1_002013 OCC/N=C(/N1CCN(CC1)\C(=N\CCO)\c2ccc(Cl)cc2)\c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L12 compound treatment 1.93097296E8 3.75E7 0.47 1.01631354E8 -4.66E7 -0.8 -0.2321 -0.2504 1733839 TimTec1_002014 Cn1c(SCc2ccoc2C(=O)O)nnc1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L13 compound treatment 1.44935438E8 -1.07E7 -0.13 1.18176064E8 -3.01E7 -0.52 -0.459 -0.8621 1368186 TimTec1_002015 NC(=O)CC(=O)c1c(O)c2ccccc2n(c3ccccc3)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L14 compound treatment 1.79465178E8 2.39E7 0.3 1.16482843E8 -3.18E7 -0.54 -0.1732 -0.2788 3082357 TimTec1_002016 Fc1ccccc1OCCNC(=O)c2ccccc2Nc3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L15 compound treatment 1.41363068E8 -1.42E7 -0.18 1.55209008E8 6930000.0 0.12 -0.0424 -0.198 3209633 TimTec1_002017 NC(=O)/C(=C/c1ccc(Cl)cc1)/NC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L16 compound treatment 2.28584802E8 7.3E7 0.92 1.21097021E8 -2.72E7 -0.47 0.3183 0.31 1533648 TimTec1_002018 CC(NC(=O)CSc1nn(c2ccccc2)c(=S)s1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L17 compound treatment 1.19197276E8 -3.64E7 -0.46 1.1231377E8 -3.6E7 -0.62 -0.7583 -0.9892 3082358 TimTec1_002019 Oc1ccc(/C=C\2/NC(=S)Nc3[nH]\c(=N\c4ccccc4)\sc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L18 compound treatment 2.05146006E8 4.95E7 0.62 1.10964327E8 -3.73E7 -0.64 -0.0122 -0.0137 3209634 TimTec1_002020 CN1C(=O)C2C=CC=CC2N=C1SCc3ccccc3F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L19 compound treatment 2.05508874E8 4.99E7 0.63 1.8974696E8 4.15E7 0.71 0.9446 0.998 3082359 TimTec1_002021 CN(C)c1ccc(cc1)n2c(C)cc(/C=N/c3ccc(O)c(c3)C(=O)O)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L20 compound treatment 1.93091072E8 3.75E7 0.47 1.25418909E8 -2.29E7 -0.39 0.0558 0.0912 3209635 TimTec1_002022 OC(=O)/C=C/C(=O)N1CCc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L21 compound treatment 1.99204733E8 4.36E7 0.55 1.99346105E8 5.11E7 0.87 1.0049 0.9745 3082361 TimTec1_002023 Fc1ccc(/C=c\2/sc3=NCCn3c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L22 compound treatment 1.26026132E8 -2.96E7 -0.37 1.77564724E8 2.93E7 0.5 0.0921 0.1477 1356390 TimTec1_002024 Cc1ccc(OCC(=O)Nc2ccc(cc2)S(=O)(=O)N3CCCC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L23 mock treatment 1.77138054E8 2.15E7 0.27 1.23308855E8 -2.5E7 -0.43 -0.1112 -0.22 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 L24 mock treatment 1.76793103E8 2.12E7 0.27 1.69470603E8 2.12E7 0.36 0.4445 0.9883 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M01 compound treatment 4.4457186E7 -1.11E8 -1.39 1.19172154E8 -2.91E7 -0.5 -1.3382 -0.9038 1265733 TimTec1_002025 CCOC(=O)c1c(C)c(sc1N)C(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M02 compound treatment 1.03568782E8 -5.2E7 -0.65 1.18628422E8 -2.97E7 -0.51 -0.8205 -0.9923 3209636 TimTec1_002026 Oc1ccc(/C=C/2\SC(=N)NC2=O)cc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M03 compound treatment 1.01752409E8 -5.38E7 -0.68 1.33110873E8 -1.52E7 -0.26 -0.6613 -0.9137 3082390 TimTec1_002027 Cc1ccc(NC(=O)OC(C)(C)C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M04 compound treatment 1.19011044E8 -3.66E7 -0.46 1.37040073E8 -1.12E7 -0.19 -0.4606 -0.9255 3209637 TimTec1_002028 COc1ccc(CC(=O)N2N=C(C)CC2(O)C(F)(F)F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M05 compound treatment 1.1134294E8 -4.43E7 -0.56 1.18911523E8 -2.94E7 -0.5 -0.7481 -0.9988 3082392 TimTec1_002029 CC(=CCc1c(O)cc(O)c2C(=O)C[C@H](Oc12)c3ccccc3)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M06 compound treatment 1.29519455E8 -2.61E7 -0.33 1.33438646E8 -1.48E7 -0.25 -0.411 -0.9922 3209638 TimTec1_002030 CN(C)C(=O)CSc1nnc(o1)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M07 compound treatment 1.46973288E8 -8630000.0 -0.11 1.45547258E8 -2730000.0 -0.05 -0.1096 -0.9296 1286462 TimTec1_002031 CN1C2N=CN(CCCO)C2C(=O)N(C)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M08 compound treatment 1.41848399E8 -1.38E7 -0.17 1.27667045E8 -2.06E7 -0.35 -0.3715 -0.9458 1699709 TimTec1_002032 COc1ccc(C(=O)Nc2ccc(cc2)S(=O)(=O)N3CCCCC3C)c(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M09 compound treatment 1.24340136E8 -3.13E7 -0.39 1.33628537E8 -1.47E7 -0.25 -0.4547 -0.9767 1409515 TimTec1_002033 CC(=O)Oc1ccn(C)c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M10 compound treatment 1.38885925E8 -1.67E7 -0.21 1.19294066E8 -2.9E7 -0.5 -0.4991 -0.9266 1211785 TimTec1_002034 CC1(C)Oc2ccc(NC(=O)C3(CCCC3)c4ccccc4)cc2O1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M11 compound treatment 1.46661456E8 -8940000.0 -0.11 1.17301585E8 -3.1E7 -0.53 -0.4543 -0.8381 1344646 TimTec1_002035 Cc1occc1C(=O)Nc2ccc(F)c(F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M12 compound treatment 1.36913088E8 -1.87E7 -0.23 1.61990907E8 1.37E7 0.23 2.0E-4 5.0E-4 1915457 TimTec1_002036 O=c1[nH]nc(SCc2ccccc2)c(=S)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M13 compound treatment 1.3759296E8 -1.8E7 -0.23 1.61385672E8 1.31E7 0.22 -0.0011 -0.0035 1068232 TimTec1_002037 COC(=O)Nc1c(C)cc(C)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M14 compound treatment 1.61508194E8 5910000.0 0.07 1.15154272E8 -3.31E7 -0.57 -0.3486 -0.6095 1147050 TimTec1_002038 Clc1ccc(OCc2ccc(o2)C(=O)NC3CCOC3=O)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M15 compound treatment 1.20674305E8 -3.49E7 -0.44 1.03675519E8 -4.46E7 -0.76 -0.8497 -0.9652 1216899 TimTec1_002039 Clc1ccccc1C(=O)c2cc(Br)ccc2NC(=O)CSC3=NCCS3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M16 compound treatment 1.41457297E8 -1.41E7 -0.18 1.25679889E8 -2.26E7 -0.39 -0.399 -0.9375 1413128 TimTec1_002040 CCCc1ccc(OCc2ccc(o2)C(=O)NCc3cccnc3)c(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M17 compound treatment 1.40102305E8 -1.55E7 -0.19 1.65821481E8 1.75E7 0.3 0.0748 0.2092 3082399 TimTec1_002041 CC(=O)OCC(=O)Nc1ccccc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M18 compound treatment 1.50283614E8 -5320000.0 -0.07 1.48712465E8 432000.0 0.01 -0.042 -0.6249 1538207 TimTec1_002042 O=C(COC(=O)c1c2CCCCc2nc3ccccc13)Nc4nc5ccccc5s4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M19 compound treatment 1.47215186E8 -8390000.0 -0.11 1.04909521E8 -4.34E7 -0.74 -0.5994 -0.7993 1322184 TimTec1_002043 CCOc1ccc2nc(SCc3nc4ccccc4[nH]3)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M20 compound treatment 1.22142207E8 -3.35E7 -0.42 1.06961456E8 -4.13E7 -0.71 -0.7969 -0.969 3209758 TimTec1_002044 CN(Cc1cccs1)C(=S)SCCO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M21 compound treatment 1.6378692E8 8180000.0 0.1 1.63449803E8 1.52E7 0.26 0.2562 0.9176 1690142 TimTec1_002045 CC(NS(=O)(=O)c1ccc(Cl)cc1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M22 compound treatment 1.47432668E8 -8170000.0 -0.1 1.15262213E8 -3.3E7 -0.57 -0.4721 -0.8219 3082402 TimTec1_002046 CC(=O)OCC(=O)Nc1cccc(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M23 mock treatment 1.43837211E8 -1.18E7 -0.15 1.58152482E8 9870000.0 0.17 0.0151 0.0674 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 M24 mock treatment 1.43479141E8 -1.21E7 -0.15 1.8969484E8 4.14E7 0.71 0.3938 0.5431 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N01 compound treatment 9.8229808E7 -5.74E7 -0.72 1.39392332E8 -8890000.0 -0.15 -0.6165 -0.8381 3209759 TimTec1_002047 Nc1nc(cc(=S)s1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N02 compound treatment 1.34312942E8 -2.13E7 -0.27 1.2448315E8 -2.38E7 -0.41 -0.4769 -0.979 1028245 TimTec1_002048 Clc1ccc(SC(=O)c2ccco2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N03 compound treatment 1.67544697E8 1.19E7 0.15 1.65162994E8 1.69E7 0.29 0.3103 0.9532 1713032 TimTec1_002049 COC(=O)c1ccccc1NC(=O)Cc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N04 compound treatment 1.60604129E8 5000000.0 0.06 1.55634857E8 7350000.0 0.13 0.1334 0.9483 3083578 TimTec1_002050 Brc1ccc(cc1)C(C#N)C(CC#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N05 compound treatment 1.15142365E8 -4.05E7 -0.51 1.13560085E8 -3.47E7 -0.59 -0.7792 -0.9969 3209760 TimTec1_002051 OC(=O)/C=C/C(=O)N1CCN(CC1)C(=O)\C=C\C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N06 compound treatment 1.49998139E8 -5600000.0 -0.07 1.47300807E8 -980000.0 -0.02 -0.0616 -0.8519 3209761 TimTec1_002052 CCc1ccc(/C=C/2\CN(C)C/C(=C\c3ccc(CC)cc3)/C2O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N07 compound treatment 9.8079758E7 -5.75E7 -0.72 8.1334769E7 -6.69E7 -1.15 -1.3206 -0.9751 1389451 TimTec1_002053 Nc1ccc2c(c1)nc(c3ccccc3)c4cc(N)ccc42 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N08 compound treatment 1.65875846E8 1.03E7 0.13 9.8650259E7 -4.96E7 -0.85 -0.5096 -0.5931 3209762 TimTec1_002054 Fc1ccc(cc1)N2C(=O)NC(=O)/C(=C\Nc3ccccc3)/C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N09 compound treatment 1.6299935E8 7400000.0 0.09 1.50042542E8 1760000.0 0.03 0.0869 0.8911 1139527 TimTec1_002055 OC(=O)c1ccc(cc1)N2Cc3ccc(Br)cc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N10 compound treatment 1.46330108E8 -9270000.0 -0.12 1.07631733E8 -4.06E7 -0.7 -0.5743 -0.814 1168036 TimTec1_002056 Cn1c(=S)n(CN2CCC3(CC2)OCCO3)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N11 compound treatment 1.05082705E8 -5.05E7 -0.63 1.52564701E8 4280000.0 0.07 -0.3963 -0.6211 1535531 TimTec1_002057 COC1CC2C(C(OC2=O)C(=O)O)C(OC)C1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N12 compound treatment 1.68845067E8 1.32E7 0.17 9.81357E7 -5.01E7 -0.86 -0.4895 -0.5599 1408618 TimTec1_002058 CCS(=O)(=O)N(CC(=O)O)c1ccc(OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N13 compound treatment 1.62632847E8 7030000.0 0.09 9.3941225E7 -5.43E7 -0.93 -0.5954 -0.6372 1306524 TimTec1_002059 CCOC(=O)CSC1C(=O)Nc2ccccc2N=C1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N14 compound treatment 1.58811127E8 3210000.0 0.04 1.14530291E8 -3.38E7 -0.58 -0.3801 -0.6562 1728948 TimTec1_002060 CCOC(=O)NC1c2ccccc2Sc3ccc(Cl)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N15 compound treatment 1.74464507E8 1.89E7 0.24 1.56208077E8 7930000.0 0.14 0.2633 0.9652 1597862 TimTec1_002061 Oc1ccc(=O)n(CNc2nccs2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N16 compound treatment 1.46329687E8 -9270000.0 -0.12 1.69783592E8 2.15E7 0.37 0.178 0.4612 3209763 TimTec1_002062 COc1ccc(cc1)c2n[nH]c(SCC(=O)N(C3CCCCC3)C4CCCCC4)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N17 compound treatment 1.64905529E8 9300000.0 0.12 1.53677327E8 5400000.0 0.09 0.1478 0.9933 3209764 TimTec1_002063 Cc1ccc(cc1)C2=CC(SC(=N)N2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N18 compound treatment 1.85670789E8 3.01E7 0.38 1.13901518E8 -3.44E7 -0.59 -0.1494 -0.2138 3083579 TimTec1_002064 Fc1ccc(CSc2ccccc2C(=O)NCc3ccco3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N19 compound treatment 1.73294665E8 1.77E7 0.22 1.43288694E8 -4990000.0 -0.09 0.0965 0.4058 3209765 TimTec1_002065 NC1=Nn2c(nnc2SC3(C1C#N)C(=O)Nc4ccccc43)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N20 compound treatment 1.61118364E8 5520000.0 0.07 1.67267653E8 1.9E7 0.33 0.2788 0.8388 1495217 TimTec1_002066 CC(=C)CC1NC2CC(C)(C)C1c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N21 compound treatment 1.56292163E8 690000.0 0.01 1.46354278E8 -1930000.0 -0.03 -0.0172 -0.5045 1163918 TimTec1_002067 COc1ccc(c(O)c1)c2nc(N)ncc2c3cscn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N22 compound treatment 9.3897834E7 -6.17E7 -0.77 1.71692029E8 2.34E7 0.4 -0.264 -0.3028 1657100 TimTec1_002068 CCN(CC)S(=O)(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N23 mock treatment 1.59641172E8 4040000.0 0.05 1.67212873E8 1.89E7 0.32 0.265 0.8078 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 N24 mock treatment 1.56683513E8 1080000.0 0.01 1.78079422E8 2.98E7 0.51 0.3703 0.7257 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O01 compound treatment 6.1144557E7 -9.45E7 -1.18 1.08740149E8 -3.95E7 -0.68 -1.3165 -0.9647 3083580 TimTec1_002069 OC(=O)[C@@H]1CSC(N1)c2coc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O02 compound treatment 9.9275544E7 -5.63E7 -0.71 9.6338331E7 -5.19E7 -0.89 -1.1284 -0.9935 3209766 TimTec1_002070 Cc1ccc(cc1)/C(=N\C#N)/NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O03 compound treatment 1.09896346E8 -4.57E7 -0.57 1.1254528E8 -3.57E7 -0.61 -0.838 -0.9995 3083581 TimTec1_002071 CCOC(=O)Nc1ccc(C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O04 compound treatment 1.0544271E8 -5.02E7 -0.63 1.26055798E8 -2.22E7 -0.38 -0.7139 -0.971 3209767 TimTec1_002072 O=C(NCc1ccccc1)/C=C/c2ccc(C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O05 compound treatment 1.13873124E8 -4.17E7 -0.52 6.1892972E7 -8.64E7 -1.48 -1.4158 -0.9025 1190059 TimTec1_002073 CNC1C2CN3CCC(O2)C13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O06 compound treatment 1.14591395E8 -4.1E7 -0.51 1.16915365E8 -3.14E7 -0.54 -0.7434 -0.9998 1479488 TimTec1_002074 Cn1c(Sc2cnn(c3ccccc3)c(=O)c2Br)nnc1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O07 compound treatment 1.18926158E8 -3.67E7 -0.46 1.0868094E8 -3.96E7 -0.68 -0.8047 -0.9822 3487465 TimTec1_002075 OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O08 compound treatment 1.34424796E8 -2.12E7 -0.27 1.13287436E8 -3.5E7 -0.6 -0.6114 -0.9331 3083582 TimTec1_002076 CN(C)C(=O)CSc1nnc(c2cccc(F)c2)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O09 compound treatment 1.1421207E8 -4.14E7 -0.52 1.15907227E8 -3.24E7 -0.55 -0.759 -0.9995 1278782 TimTec1_002077 COc1ccc2c3CCN4CC5C(C)OC=C(OC(=O)C)[C@H]5C[C@H]4c3[nH]c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O10 compound treatment 9.1597565E7 -6.4E7 -0.8 1.04161088E8 -4.41E7 -0.76 -1.1018 -0.9995 3083583 TimTec1_002078 O=C(ON1C(=O)CCC1=O)/C=C/c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O11 compound treatment 1.03832725E8 -5.18E7 -0.65 1.60838634E8 1.26E7 0.21 -0.3072 -0.4491 1523507 TimTec1_002079 NC(=O)c1sc2nc(ccc2c1N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O12 compound treatment 2.08915979E8 5.33E7 0.67 2.20306678E8 7.2E7 1.23 1.3447 0.9587 3083584 TimTec1_002080 CCOC(=O)c1cnc2cccc[n+]2c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O13 compound treatment 1.06740096E8 -4.89E7 -0.61 1.58248369E8 9970000.0 0.17 -0.3128 -0.4916 1224089 TimTec1_002081 O=C(Nc1cccc(NC(=O)C2CC2)c1)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O14 compound treatment 1.17836841E8 -3.78E7 -0.47 1.46743849E8 -1540000.0 -0.03 -0.3536 -0.7452 3083585 TimTec1_002082 Fc1c(F)c(F)c(OCc2ccc(o2)C(=O)N3CCOCC3)c(F)c1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O15 compound treatment 1.27084108E8 -2.85E7 -0.36 1.05619774E8 -4.27E7 -0.73 -0.7693 -0.9461 1612278 TimTec1_002083 CC(=O)Nc1nonc1NC(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O16 compound treatment 1.27906372E8 -2.77E7 -0.35 9.5081689E7 -5.32E7 -0.91 -0.8896 -0.9127 1443254 TimTec1_002084 Clc1ccc(OCc2ccc(o2)C(=O)NCc3cccc(Cl)c3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O17 compound treatment 1.48945846E8 -6660000.0 -0.08 1.35483452E8 -1.28E7 -0.22 -0.2139 -0.9126 1195533 TimTec1_002085 CC(=O)OCC(=O)Nc1ccccc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O18 compound treatment 1.17830969E8 -3.78E7 -0.47 1.40750432E8 -7530000.0 -0.13 -0.4262 -0.8679 1402999 TimTec1_002086 Cc1ccc(NC(=O)c2ccc(CSc3ccccn3)cc2)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O19 compound treatment 1.22220088E8 -3.34E7 -0.42 1.55792384E8 7510000.0 0.13 -0.2052 -0.4684 1194370 TimTec1_002087 C=CCON1C(N(CC1=O)C(=O)Nc2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O20 compound treatment 1.10509465E8 -4.51E7 -0.57 1.48707804E8 427000.0 0.01 -0.3948 -0.6979 3209769 TimTec1_002088 COc1ccc(Sc2cccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O21 compound treatment 1.38267968E8 -1.73E7 -0.22 1.56679427E8 8400000.0 0.14 -0.0521 -0.1999 3209770 TimTec1_002089 COc1ccc(CC(C)(N)C(=O)O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O22 compound treatment 1.18910285E8 -3.67E7 -0.46 1.60728389E8 1.24E7 0.21 -0.1748 -0.3446 3083586 TimTec1_002090 C=CCNC(=S)C(=O)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O23 mock treatment 1.36684111E8 -1.89E7 -0.24 1.3992679E8 -8350000.0 -0.14 -0.2689 -0.9706 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 O24 mock treatment 1.35543917E8 -2.01E7 -0.25 1.44190794E8 -4090000.0 -0.07 -0.2274 -0.8708 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P01 compound treatment 9.4956065E7 -6.06E7 -0.76 1.51297066E8 3020000.0 0.05 -0.5014 -0.6576 3083588 TimTec1_002091 Fc1ccc(SCSc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P02 compound treatment 1.07956423E8 -4.76E7 -0.6 8.8402695E7 -5.99E7 -1.02 -1.1474 -0.967 3209771 TimTec1_002092 COc1cc(cc(OC)c1OC)C(=O)Sc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P03 compound treatment 1.28342688E8 -2.73E7 -0.34 1.56337526E8 8060000.0 0.14 -0.1443 -0.3913 1455929 TimTec1_002093 Clc1ccc(OCC(=O)N2CCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P04 compound treatment 5.3330102E7 -1.02E8 -1.28 9.0568709E7 -5.77E7 -0.99 -1.6057 -0.9917 3209887 TimTec1_002094 Cc1ccccc1C(C#N)C(CC#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P05 compound treatment 1.23976861E8 -3.16E7 -0.4 1.50782977E8 2500000.0 0.04 -0.2502 -0.6271 3209888 TimTec1_002095 NS(=O)(=O)c1ccc(/N=C/c2ccc(C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P06 compound treatment 1.37998072E8 -1.76E7 -0.22 1.46856428E8 -1420000.0 -0.02 -0.1734 -0.7804 1275062 TimTec1_002096 OC(=O)C1(CC2CC3C1)CC(C2)(C3)n4cnc(Cl)n4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P07 compound treatment 1.34642858E8 -2.1E7 -0.26 1.57410428E8 9130000.0 0.16 -0.0754 -0.2465 3209889 TimTec1_002097 C/C(=N\n1c(n[nH]c1=O)c2ccccc2)/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P08 compound treatment 1.34254273E8 -2.13E7 -0.27 1.63674452E8 1.54E7 0.26 -0.003 -0.0081 3209890 TimTec1_002098 CC(=O)N1c2ccccc2CCc3ccc(NC(=S)NC(=O)/C=C/c4ccccc4)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P09 compound treatment 1.16450959E8 -3.92E7 -0.49 1.26954918E8 -2.13E7 -0.37 -0.6054 -0.9893 1360532 TimTec1_002099 O=C(C1CCCNC1=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P10 compound treatment 1.13890683E8 -4.17E7 -0.52 1.41824347E8 -6460000.0 -0.11 -0.4481 -0.838 3083595 TimTec1_002100 Cc1nnc(SCc2c(C)cc(C)cc2C)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P11 compound treatment 1.34537437E8 -2.11E7 -0.26 1.62316229E8 1.4E7 0.24 -0.017 -0.0475 1439208 TimTec1_002101 CC(C)C1C(O)C(=O)C2C3CCCC(C)(C)C3CC(OC(=O)C)C2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P12 compound treatment 1.10466198E8 -4.51E7 -0.57 1.46706928E8 -1570000.0 -0.03 -0.4194 -0.7399 1739919 TimTec1_002102 COc1ccc(NC(=O)Nc2ccc(cc2)N3CCCC3=O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P13 compound treatment 1.10375359E8 -4.52E7 -0.57 1.35175622E8 -1.31E7 -0.22 -0.5598 -0.9176 3209891 TimTec1_002103 C/C(=N/c1ccc(cc1)S(=O)(=O)N2CCOCC2)/Nc3ccc(C(=O)O)c(O)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P14 compound treatment 1.32448688E8 -2.32E7 -0.29 1.5185519E8 3570000.0 0.06 -0.1621 -0.5462 3083596 TimTec1_002104 FC(F)(F)c1cc(NCCC(=O)c2ccccc2)ccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P15 compound treatment 1.37626215E8 -1.8E7 -0.23 1.20733571E8 -2.75E7 -0.47 -0.4929 -0.943 1614491 TimTec1_002105 Oc1nn(CNc2ccc(F)cc2)c(=O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P16 compound treatment 1.47354301E8 -8250000.0 -0.1 1.64556168E8 1.63E7 0.28 0.1238 0.4167 3209892 TimTec1_002106 CC(C)CC1C(=NN(C(=S)c2ccc(C)cc2)C1(C)O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P17 compound treatment 1.25127725E8 -3.05E7 -0.38 1.65092847E8 1.68E7 0.29 -0.0668 -0.1396 3209893 TimTec1_002107 OC(=O)c1ccccc1C2SCC(=O)N2NC(=S)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P18 compound treatment 1.23237371E8 -3.24E7 -0.41 1.41712676E8 -6570000.0 -0.11 -0.3666 -0.8702 1488668 TimTec1_002108 CC(C)(C)NC(=O)c1ccccc1SCc2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P19 compound treatment 1.35791999E8 -1.98E7 -0.25 1.5510221E8 6820000.0 0.12 -0.0932 -0.3393 3209894 TimTec1_002109 CCOC(=O)C1=C(Sc2nnc(n2N=C1N)C(F)(F)F)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P20 compound treatment 1.14534428E8 -4.11E7 -0.52 1.36927431E8 -1.14E7 -0.19 -0.5017 -0.9112 1730773 TimTec1_002110 CCC(=O)Nc1sc(Cc2ccccc2)c(C)c1C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P21 compound treatment 1.20104691E8 -3.55E7 -0.45 1.53279455E8 5000000.0 0.09 -0.2544 -0.561 1494523 TimTec1_002111 COc1cc(cc(OC)c1OC)C(=O)n2c(SCc3ccc(F)cc3)nc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P22 compound treatment 1.28311694E8 -2.73E7 -0.34 1.46087509E8 -2190000.0 -0.04 -0.2686 -0.78 3209895 TimTec1_002112 COC(=O)c1c(NC(=O)Nc2ccccc2)sc3CCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P23 mock treatment 1.2116114E8 -3.44E7 -0.43 1.51208852E8 2930000.0 0.05 -0.2701 -0.6209 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2068 P24 mock treatment 1.30589395E8 -2.5E7 -0.31 1.55762766E8 7480000.0 0.13 -0.1313 -0.3874 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A01 compound treatment 1.4993518E8 -4920000.0 -0.06 1.67132047E8 -4430000.0 -0.08 -0.0973 -0.9948 1161050 TimTec1_002113 COc1cccc(c1)C2C(=C(N)Oc3[nH]c(=O)[nH]c(=O)c23)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A02 compound treatment 1.59465067E8 4610000.0 0.06 1.72588033E8 1020000.0 0.02 0.0533 0.8819 3083648 TimTec1_002114 COc1ccccc1NC(=O)c2cccc(c2)N3C(=O)C4CC=CCC4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A03 compound treatment 1.55083885E8 230000.0 0.0 1.59225449E8 -1.23E7 -0.21 -0.1473 -0.6974 3209896 TimTec1_002115 COC(=O)c1ccc(NC(=S)N(C(C)C)C(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A04 compound treatment 1.73967518E8 1.91E7 0.24 1.68423277E8 -3140000.0 -0.05 0.1315 0.5353 3083650 TimTec1_002116 Fc1ccccc1OC(=O)CCCC(=O)n2nnc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A05 compound treatment 1.77410956E8 2.26E7 0.28 1.93298162E8 2.17E7 0.37 0.4632 0.9909 3209897 TimTec1_002117 C(Nc1ccc(NCc2cccs2)cc1)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A06 compound treatment 1.67986618E8 1.31E7 0.16 1.93008805E8 2.14E7 0.37 0.3761 0.9346 3083652 TimTec1_002118 CCN(CC)C(=S)NC1CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A07 compound treatment 1.64237435E8 9380000.0 0.12 1.7640893E8 4850000.0 0.08 0.1419 0.9853 3209898 TimTec1_002119 Cn1c(=O)c(C/2=NNC(=O)\C2=C/C=C/c3ccccc3)c(O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A08 compound treatment 7.6484663E7 -7.84E7 -0.98 7.408983E7 -9.75E7 -1.67 -1.875 -0.9682 1389733 TimTec1_002120 OC1(CCCCC1)c2cc(=N)sc3nc4ccccc4n23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A09 compound treatment 1.72918156E8 1.81E7 0.23 1.65939521E8 -5620000.0 -0.1 0.0922 0.3743 3209899 TimTec1_002121 Cn1c(SCc2ccccc2)nc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A10 compound treatment 1.63943745E8 9090000.0 0.11 1.16440083E8 -5.51E7 -0.94 -0.5866 -0.6172 3209900 TimTec1_002122 CN1C(=O)C(=Cc2ccc(o2)c3cccc(Cl)c3)C(=O)N(C)C1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A11 compound treatment 1.78325108E8 2.35E7 0.29 2.0236136E8 3.08E7 0.53 0.581 0.9621 3083655 TimTec1_002123 CC(Sc1nnnn1c2ccccc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A12 compound treatment 1.77537228E8 2.27E7 0.28 1.95866939E8 2.43E7 0.42 0.4954 0.9828 1256717 TimTec1_002124 O=C(Nc1ccc(cc1)S(=O)(=O)N2CCc3ccccc23)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A13 compound treatment 1.64839195E8 9990000.0 0.13 1.6645765E8 -5110000.0 -0.09 0.0268 0.1753 3083658 TimTec1_002125 CCn1c(ccc1c2ccccc2)C(O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A14 compound treatment 1.74062669E8 1.92E7 0.24 1.1971212E8 -5.19E7 -0.89 -0.4572 -0.4971 3209901 TimTec1_002126 CN1/C(=C/C(=S)C(C)(C)C)/Sc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A15 compound treatment 1.0448631E8 -5.04E7 -0.63 1.99811066E8 2.82E7 0.48 -0.1049 -0.1318 1429079 TimTec1_002127 O=C(CC1CCC1)Nc2ccc(Oc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A16 compound treatment 1.7464641E8 1.98E7 0.25 1.3116547E8 -4.04E7 -0.69 -0.3134 -0.4266 1196328 TimTec1_002128 CC(C)CN(CC(C)C)CN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A17 compound treatment 1.78632547E8 2.38E7 0.3 1.69391166E8 -2170000.0 -0.04 0.1846 0.6142 3083661 TimTec1_002129 Clc1ccc(CSc2n[nH]c(=O)[nH]c2=O)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A18 compound treatment 1.92391618E8 3.75E7 0.47 1.22344636E8 -4.92E7 -0.84 -0.2628 -0.2723 1702303 TimTec1_002130 COC(=O)C1CCc2sc(N)c(C(=O)OC)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A19 compound treatment 1.38051573E8 -1.68E7 -0.21 1.89266325E8 1.77E7 0.3 0.0652 0.1767 1553773 TimTec1_002131 Oc1ccccc1CNc2ccc(cc2)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A20 compound treatment 1.2310759E8 -3.17E7 -0.4 1.26357313E8 -4.52E7 -0.77 -0.8288 -0.9523 3083664 TimTec1_002132 CC1CCCCC1NC(=O)c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A21 compound treatment 1.82703736E8 2.78E7 0.35 1.0996508E8 -6.16E7 -1.05 -0.4986 -0.4488 1072652 TimTec1_002133 O=C(Nc1sc2CCCCc2c1C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A22 compound treatment 1.8654388E8 3.17E7 0.4 1.08889604E8 -6.27E7 -1.07 -0.4775 -0.4174 1225174 TimTec1_002134 Clc1ccccc1NC(=O)N(C(CC(=O)C2CC2)c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A23 mock treatment 1.9138514E8 3.65E7 0.46 1.47913926E8 -2.36E7 -0.4 0.0378 0.0618 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 A24 mock treatment 1.94173915E8 3.93E7 0.49 1.72349208E8 786000.0 0.01 0.3583 0.7261 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B01 compound treatment 1.40693651E8 -1.42E7 -0.18 1.74764425E8 3200000.0 0.05 -0.0869 -0.4673 3209902 TimTec1_002135 CCC(C)NC(=O)Nc1ccc(Br)cc1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B02 mock treatment 1.34133463E8 -2.07E7 -0.26 1.42928307E8 -2.86E7 -0.49 -0.5304 -0.956 1402072 TimTec1_002136 CC(NCc1cccs1)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B03 compound treatment 2.10900957E8 5.6E7 0.7 1.32181327E8 -3.94E7 -0.67 0.0205 0.021 3209903 TimTec1_002137 Cc1ccc(CCNC(=O)NC(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B04 compound treatment 1.78111226E8 2.33E7 0.29 1.61931274E8 -9630000.0 -0.16 0.0897 0.2677 1539581 TimTec1_002138 O=P(Cc1ccccc1)(N(CC2CCCO2)Cc3cccs3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B05 compound treatment 1.61321743E8 6470000.0 0.08 1.0230635E8 -6.93E7 -1.19 -0.7809 -0.6572 3083710 TimTec1_002139 Clc1ccc(NC(=O)c2ccc(CSc3ncccn3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B06 compound treatment 1.03652402E8 -5.12E7 -0.64 1.15850249E8 -5.57E7 -0.95 -1.1285 -0.9815 3209904 TimTec1_002140 O=C1OC2(CCCCC2)C(=C1)NCCOC3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B07 compound treatment 1.31834377E8 -2.3E7 -0.29 1.22282842E8 -4.93E7 -0.84 -0.8007 -0.898 3083712 TimTec1_002141 CCOC(=O)c1cc(Br)ccc1OCc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B08 compound treatment 1.43415332E8 -1.14E7 -0.14 1.05426598E8 -6.61E7 -1.13 -0.902 -0.7904 1534717 TimTec1_002142 Nc1nnnn1CC(=O)OCC(=O)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B09 compound treatment 1.22783141E8 -3.21E7 -0.4 1.2078103E8 -5.08E7 -0.87 -0.8992 -0.9387 1230328 TimTec1_002143 NNC(=O)c1nnn(c1CN2CCCCC2)c3nonc3N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B10 compound treatment 1.07597239E8 -4.73E7 -0.59 1.13376792E8 -5.82E7 -1.0 -1.1235 -0.9693 3209905 TimTec1_002144 CCN(CC)C(=O)CSc1nc(N)c(C#N)c(CC(C)C)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B11 compound treatment 1.22694758E8 -3.22E7 -0.4 1.82200309E8 1.06E7 0.18 -0.1565 -0.3536 1502579 TimTec1_002145 CCC(=O)Nc1cccc(c1)c2nc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B12 compound treatment 1.20182697E8 -3.47E7 -0.43 1.20046927E8 -5.15E7 -0.88 -0.9311 -0.9469 3209906 TimTec1_002146 Cc1ccc2[nH]c(=O)c(/C=N/C(CO)(CO)CO)c(O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B13 compound treatment 1.38628824E8 -1.62E7 -0.2 1.11768466E8 -5.98E7 -1.02 -0.8677 -0.8314 1455910 TimTec1_002147 O=C(CCc1ccccc1)Nc2ccc(cc2)c3nc4ccccc4o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B14 compound treatment 1.26137966E8 -2.87E7 -0.36 1.76430937E8 4870000.0 0.08 -0.1958 -0.5296 3083716 TimTec1_002148 CC(NC(=S)NC(=O)c1cccs1)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B15 compound treatment 1.90162479E8 3.53E7 0.44 1.66967084E8 -4600000.0 -0.08 0.2576 0.5725 1725795 TimTec1_002149 CC(C)(C)c1ccccc1OCC(=O)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B16 compound treatment 1.8440892E8 2.96E7 0.37 1.68551683E8 -3010000.0 -0.05 0.2257 0.603 3210019 TimTec1_002150 CCC1CC(CNC=C2C(=O)CC(C)(C)CC2=O)C1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B17 compound treatment 1.82744589E8 2.79E7 0.35 1.17991497E8 -5.36E7 -0.92 -0.401 -0.4086 1148431 TimTec1_002151 CC1CN(CC(C)O1)C(=O)c2cccc(c2)C(=O)N3CC(C)OC(C)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B18 compound treatment 1.24647202E8 -3.02E7 -0.38 1.16202985E8 -5.54E7 -0.95 -0.938 -0.9191 3210020 TimTec1_002152 COc1ccc(CCC(=O)Nc2cccc(C)n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B19 compound treatment 1.36496539E8 -1.84E7 -0.23 1.75444484E8 3880000.0 0.07 -0.1159 -0.4834 1183356 TimTec1_002153 COC(=O)C(c1ccccc1)C2(O)CC(C)N(C)CC2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B20 compound treatment 8.6840237E7 -6.8E7 -0.85 7.6172461E7 -9.54E7 -1.63 -1.7579 -0.9542 3083720 TimTec1_002154 Cc1cc(O)ccc1Sc2ccc(O)cc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B21 compound treatment 1.60096584E8 5240000.0 0.07 1.33051653E8 -3.85E7 -0.66 -0.4197 -0.6334 3210021 TimTec1_002155 CC(C)C1N2C(=S)NC(C)(C)CC2(C)OC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B22 compound treatment 1.94861033E8 4.0E7 0.5 1.06126332E8 -6.54E7 -1.12 -0.4372 -0.3562 1240094 TimTec1_002156 COc1ccccc1C(=O)Nc2ccc(CC#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B23 mock treatment 1.92617819E8 3.78E7 0.47 1.07994248E8 -6.36E7 -1.09 -0.4345 -0.3661 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 B24 mock treatment 2.10823441E8 5.6E7 0.7 1.58919499E8 -1.26E7 -0.22 0.3434 0.4674 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C01 compound treatment 1.89481419E8 3.46E7 0.43 1.93412197E8 2.18E7 0.37 0.5716 0.9972 3210022 TimTec1_002157 OCCNC(=O)c1cccc(c1)C(=O)NCCO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C02 compound treatment 1.75608309E8 2.08E7 0.26 1.38414537E8 -3.31E7 -0.57 -0.2171 -0.3478 3210023 TimTec1_002158 Cn1nccc1Nc2ccc(OC(=O)c3ccnn3C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C03 compound treatment 1.68053704E8 1.32E7 0.17 1.82750421E8 1.12E7 0.19 0.2525 0.9974 3083722 TimTec1_002159 COC(=O)c1ccc(NC(=S)N(CC(C)C)CC(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C04 compound treatment 1.8464266E8 2.98E7 0.37 1.98656173E8 2.71E7 0.46 0.5922 0.9943 3210024 TimTec1_002160 Cc1ccc(OC(=O)c2ccccc2)c(c1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C05 compound treatment 1.4590447E8 -8950000.0 -0.11 1.32577989E8 -3.9E7 -0.67 -0.5513 -0.8146 3083724 TimTec1_002161 OC(=O)CC(Sc1cccs1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C06 compound treatment 1.12523314E8 -4.23E7 -0.53 1.1187351E8 -5.97E7 -1.02 -1.098 -0.9535 1038092 TimTec1_002162 Cc1ccc(O)c(c1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C07 compound treatment 1.10890209E8 -4.4E7 -0.55 1.07927961E8 -6.36E7 -1.09 -1.1602 -0.9503 1602769 TimTec1_002163 Cc1ccc(cc1)c2nn(C3OC(CO)C(O)C3O)c(=S)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C08 compound treatment 1.06259119E8 -4.86E7 -0.61 1.44527391E8 -2.7E7 -0.46 -0.7583 -0.9908 1372480 TimTec1_002164 OC1CC(N(C1)C(=O)Oc2ccccc2)C(=O)OCC(=O)c3ccc(cc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C09 compound treatment 1.2514917E8 -2.97E7 -0.37 9.0786733E7 -8.08E7 -1.38 -1.2412 -0.8667 3083763 TimTec1_002165 Clc1ccc(cc1Cl)N2NC(=O)/C(=C/C=C/c3ccccc3)/C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C10 compound treatment 8.7296554E7 -6.76E7 -0.85 8.2211583E7 -8.94E7 -1.53 -1.6808 -0.9612 3083765 TimTec1_002166 CC1(C)CC(=O)C/C(=N\c2ccc3[nH]c(=O)[nH]c3c2)/C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C11 compound treatment 1.19202545E8 -3.57E7 -0.45 1.03008007E8 -6.86E7 -1.17 -1.146 -0.9126 3210025 TimTec1_002167 CNC(=O)c1cccc(NC(=S)NC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C12 compound treatment 1.07254655E8 -4.76E7 -0.6 1.05594998E8 -6.6E7 -1.13 -1.2207 -0.9556 3210026 TimTec1_002168 Clc1ccccc1C(=O)Oc2ccc3ccccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C13 compound treatment 1.24272734E8 -3.06E7 -0.38 9.7889323E7 -7.37E7 -1.26 -1.163 -0.8823 1014674 TimTec1_002169 OC(=O)c1ccc([nH]1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C14 compound treatment 1.1047269E8 -4.44E7 -0.56 9.384363E7 -7.77E7 -1.33 -1.3344 -0.9253 1322060 TimTec1_002170 COc1ccccc1C(=O)Nc2ccc(C)cc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C15 compound treatment 9.8214164E7 -5.66E7 -0.71 9.4867149E7 -7.67E7 -1.31 -1.4308 -0.9584 3083771 TimTec1_002171 COC(=O)c1ccccc1/N=C/C=C(/O)\c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C16 compound treatment 9.612151E7 -5.87E7 -0.74 8.2006319E7 -8.96E7 -1.53 -1.605 -0.9436 1430542 TimTec1_002172 CC(C)c1ccccc1NC(=O)c2cc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C17 compound treatment 9.1861375E7 -6.3E7 -0.79 1.01336619E8 -7.02E7 -1.2 -1.4088 -0.9793 1190438 TimTec1_002173 OC(=O)c1ccc(CNC(=O)c2cocc2C(=O)O)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C18 compound treatment 9.1454787E7 -6.34E7 -0.8 8.9991923E7 -8.16E7 -1.4 -1.5497 -0.9644 1645535 TimTec1_002174 Cc1ccccc1NC(=O)Nc2ccc(OCc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C19 compound treatment 9.5007578E7 -5.98E7 -0.75 1.01891486E8 -6.97E7 -1.19 -1.3742 -0.9751 3210027 TimTec1_002175 Clc1ccc(cc1)C2CC(=NN2c3ccccc3)C4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C20 compound treatment 8.6710947E7 -6.81E7 -0.85 9.215811E7 -7.94E7 -1.36 -1.5656 -0.975 1618185 TimTec1_002176 Cc1ccc(cc1)c2ccc(OCC(=O)NC3CCCC3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C21 compound treatment 9.2195216E7 -6.27E7 -0.79 1.00246566E8 -7.13E7 -1.22 -1.419 -0.9773 1272849 TimTec1_002177 OC(=O)CCc1nc2ccccc2nc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C22 compound treatment 1.07153366E8 -4.77E7 -0.6 8.9947618E7 -8.16E7 -1.4 -1.411 -0.9284 3210028 TimTec1_002178 C(Oc1ccc(/C=N/n2nnnc2Nc3ccccc3)cc1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C23 mock treatment 1.24377587E8 -3.05E7 -0.38 9.1289449E7 -8.03E7 -1.37 -1.242 -0.8708 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 C24 mock treatment 1.06090003E8 -4.88E7 -0.61 9.751092E7 -7.41E7 -1.27 -1.3289 -0.9442 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D01 compound treatment 1.15820126E8 -3.9E7 -0.49 1.58673049E8 -1.29E7 -0.22 -0.5023 -0.9352 1308579 TimTec1_002179 COc1ccc(CCNC(=O)Nc2ccc(Cl)cc2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D02 compound treatment 1.10503032E8 -4.44E7 -0.56 1.67810984E8 -3750000.0 -0.06 -0.4388 -0.7835 3083776 TimTec1_002180 CCSc1nnc(C)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D03 compound treatment 1.14412075E8 -4.04E7 -0.51 1.74504426E8 2940000.0 0.05 -0.3231 -0.6338 3210029 TimTec1_002181 Fc1ccccc1NC(=O)CCCCc2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D04 compound treatment 1.09704904E8 -4.51E7 -0.57 1.77400124E8 5840000.0 0.1 -0.3298 -0.5735 1325980 TimTec1_002182 CN1CCN(CC1)C(=S)NC(CC(=O)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D05 compound treatment 1.17843538E8 -3.7E7 -0.46 1.90230765E8 1.87E7 0.32 -0.1023 -0.1816 3083779 TimTec1_002183 O=C(CSC1=NCCS1)NC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D06 compound treatment 1.11905892E8 -4.29E7 -0.54 1.83878353E8 1.23E7 0.21 -0.2319 -0.4008 1681619 TimTec1_002184 CC1(C)CC(CC(C)(C)N1)NC(=O)c2ccc(cc2)n3cnnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D07 compound treatment 1.00986558E8 -5.39E7 -0.68 1.87287462E8 1.57E7 0.27 -0.2875 -0.3952 3083781 TimTec1_002185 COC(=O)c1ccc(CSc2nccn2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D08 compound treatment 1.09678938E8 -4.52E7 -0.57 1.50457809E8 -2.11E7 -0.36 -0.6562 -0.9764 1532072 TimTec1_002186 CCN(CC)CCN1C(=O)Cn2c(C)c(C)c3cccc1c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D09 compound treatment 1.05948287E8 -4.89E7 -0.61 1.41142481E8 -3.04E7 -0.52 -0.802 -0.9967 3083783 TimTec1_002187 Clc1ccc(/C=C/C(=O)NCC2CCCO2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D10 compound treatment 1.33020046E8 -2.18E7 -0.27 1.63328397E8 -8230000.0 -0.14 -0.2934 -0.9523 1189768 TimTec1_002188 CCCc1cc(O)nc(SCC(=O)NCC2(CC3CC4CC(C3)C2)C4)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D11 compound treatment 1.09792254E8 -4.51E7 -0.57 8.1526806E7 -9.0E7 -1.54 -1.4895 -0.9073 1607604 TimTec1_002189 CCC(=O)Nc1cc2ccccc2cc1NC(=O)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D12 compound treatment 1.05886521E8 -4.9E7 -0.61 8.9325391E7 -8.22E7 -1.41 -1.4298 -0.9309 1415304 TimTec1_002190 O=C(CC(C1C(=O)NC(=S)NC1=O)c2ccccc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D13 compound treatment 1.31202743E8 -2.37E7 -0.3 9.0244618E7 -8.13E7 -1.39 -1.1941 -0.839 3083786 TimTec1_002191 Cn1c(SCC(=O)NN)nnc1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D14 compound treatment 1.09302919E8 -4.56E7 -0.57 7.8599045E7 -9.3E7 -1.59 -1.5293 -0.9045 1536582 TimTec1_002192 CC(=O)OC(OC(=O)C)C1(OC2C=C1)C3C2C(=O)N(C3=O)c4ccc(OC(=O)C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D15 compound treatment 1.39994862E8 -1.49E7 -0.19 7.6146816E7 -9.54E7 -1.63 -1.2867 -0.7827 3083820 TimTec1_002193 FC(F)(F)Oc1ccc(NC(=O)CSc2nc3ccccc3[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D16 compound treatment 1.19663661E8 -3.52E7 -0.44 7.7431397E7 -9.41E7 -1.61 -1.4515 -0.8688 3210030 TimTec1_002194 COc1ccc(cc1)C(CC(=O)O)NC(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D17 compound treatment 1.0963929E8 -4.52E7 -0.57 8.1139285E7 -9.04E7 -1.55 -1.4956 -0.9072 1372790 TimTec1_002195 Cc1cccc(N2CCN(CC2)C(=O)CN3C(=O)c4ccccc4C3=O)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D18 compound treatment 8.6286135E7 -6.86E7 -0.86 8.2300895E7 -8.93E7 -1.53 -1.6887 -0.9631 3210031 TimTec1_002196 COc1ccc(Cl)c(c1)C(=O)OCC(=O)Nc2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D19 compound treatment 1.19074058E8 -3.58E7 -0.45 7.9926148E7 -9.16E7 -1.57 -1.4266 -0.8743 1594222 TimTec1_002197 CCC(=O)OC1(Cc2ccc(CC)cc2)CC(C)N(C)CC1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D20 compound treatment 9.2014373E7 -6.28E7 -0.79 6.7819746E7 -1.04E8 -1.78 -1.8131 -0.9332 3083824 TimTec1_002198 S=C(NC1CCCCC1)NN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D21 compound treatment 1.06063656E8 -4.88E7 -0.61 8.773683E7 -8.38E7 -1.43 -1.4474 -0.9278 1669241 TimTec1_002199 CC1(O)N(CC(=O)O)C(=O)OC21CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D22 compound treatment 1.10058533E8 -4.48E7 -0.56 7.4580984E7 -9.7E7 -1.66 -1.5712 -0.8965 1421950 TimTec1_002200 Nc1ccc(CC(CCC(=O)O)C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D23 mock treatment 1.13049268E8 -4.18E7 -0.52 9.2623539E7 -7.89E7 -1.35 -1.3263 -0.915 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 D24 mock treatment 1.11302925E8 -4.36E7 -0.55 9.1537593E7 -8.0E7 -1.37 -1.355 -0.9187 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E01 compound treatment 1.81272517E8 2.64E7 0.33 2.20477713E8 4.89E7 0.84 0.8264 0.9177 1882539 TimTec1_002201 CCCNC(=O)c1ccccc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E02 compound treatment 2.00945277E8 4.61E7 0.58 2.23897469E8 5.23E7 0.9 1.0423 0.9776 1476398 TimTec1_002202 Fc1ccccc1OC(=O)CCCC(=O)Nc2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E03 compound treatment 2.03921032E8 4.91E7 0.62 2.4522864E8 7.37E7 1.26 1.3269 0.9456 3083828 TimTec1_002203 COC(=O)c1ccc(NC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E04 compound treatment 2.09537067E8 5.47E7 0.69 2.177034E8 4.61E7 0.79 1.0435 0.9975 3210032 TimTec1_002204 CC(C)(C)c1cc(Cl)cc(c1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E05 compound treatment 1.98523598E8 4.37E7 0.55 2.2615143E8 5.46E7 0.93 1.0481 0.9676 1345007 TimTec1_002205 COc1ccc(OC)c(c1)S(=O)(=O)c2c(OC)ccc(OC)c2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E06 compound treatment 1.72220722E8 1.74E7 0.22 2.13168505E8 4.16E7 0.71 0.6576 0.883 1083599 TimTec1_002206 C1CCN(CC1)SN2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E07 compound treatment 1.80843144E8 2.6E7 0.33 1.91253306E8 1.97E7 0.34 0.4689 0.9999 3083830 TimTec1_002207 Nc1nnc(CSc2cccc3cccnc23)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E08 compound treatment 2.15361176E8 6.05E7 0.76 1.60844384E8 -1.07E7 -0.18 0.407 0.5212 1510605 TimTec1_002208 COC(=O)Nc1c(C)n(C)n(c2ccccc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E09 compound treatment 2.27383159E8 7.25E7 0.91 2.1725295E8 4.57E7 0.78 1.1964 0.9972 3210148 TimTec1_002209 Brc1cccc(c1)N2NC(=O)/C(=C/3\C(=O)Nc4ccccc34)/C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E10 compound treatment 2.20139965E8 6.53E7 0.82 1.58976915E8 -1.26E7 -0.22 0.4268 0.5039 1411763 TimTec1_002210 CCCc1cc(=O)nc(SCc2nc3ccccc3[nH]2)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E11 compound treatment 1.90111156E8 3.53E7 0.44 2.03228741E8 3.17E7 0.54 0.696 0.9949 3210149 TimTec1_002211 OCCN(CCO)CC(O)C1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E12 compound treatment 1.88942325E8 3.41E7 0.43 2.13993834E8 4.24E7 0.73 0.816 0.9681 1920607 TimTec1_002212 CC(C)CN(CC(C)C)C(=O)Nc1ccccc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E13 compound treatment 2.12369867E8 5.75E7 0.72 2.05820648E8 3.43E7 0.59 0.9248 0.9947 1527966 TimTec1_002213 Cc1cc(C)cc(OCc2ccc(o2)C(=O)NN)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E14 compound treatment 1.71374087E8 1.65E7 0.21 2.45045649E8 7.35E7 1.26 1.036 0.8126 1183896 TimTec1_002214 CN(Cc1c(C)nc2c(C)cc(C)cc2c1O)C3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E15 compound treatment 1.84438405E8 2.96E7 0.37 1.89717815E8 1.82E7 0.31 0.4822 0.9961 3083835 TimTec1_002215 CC1(C)CC(CC(C)(C)N1)/N=C/c2ccccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E16 compound treatment 1.8111595E8 2.63E7 0.33 1.91150612E8 1.96E7 0.34 0.47 1.0 1259208 TimTec1_002216 CC(C)CN(CC(C)C)C(=O)COc1ccc(cc1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E17 compound treatment 1.20069339E8 -3.48E7 -0.44 1.7209467E8 531000.0 0.01 -0.3021 -0.6922 1657881 TimTec1_002217 COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E18 compound treatment 1.330129E8 -2.18E7 -0.27 1.72955689E8 1390000.0 0.02 -0.1769 -0.6432 1561850 TimTec1_002218 O=C(Nc1ccc(cc1)C(=O)OC2CCCCC2)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E19 compound treatment 1.49161609E8 -5690000.0 -0.07 1.9196437E8 2.04E7 0.35 0.1964 0.5511 3210150 TimTec1_002219 COc1ccc(/C=C\2/SC(=S)N(CCC(=O)O)C2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E20 compound treatment 1.49464945E8 -5390000.0 -0.07 1.30627476E8 -4.09E7 -0.7 -0.5433 -0.7717 1395502 TimTec1_002220 O=C(CCc1ccccc1)Nc2ccc(cc2)C(=O)OC3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E21 compound treatment 1.42034631E8 -1.28E7 -0.16 2.04267437E8 3.27E7 0.56 0.2821 0.4844 3210151 TimTec1_002221 OC(=O)CCCNc1ncnc2ccc(Br)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E22 compound treatment 1.67666823E8 1.28E7 0.16 1.45507867E8 -2.61E7 -0.45 -0.2017 -0.4255 1511409 TimTec1_002222 O=C1NC(=O)C(CCc2ccncc2)(CCc3ccncc3)C(=O)N1Cc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E23 mock treatment 1.97917027E8 4.31E7 0.54 1.75055989E8 3490000.0 0.06 0.4243 0.7806 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 E24 mock treatment 1.77010895E8 2.22E7 0.28 1.98948107E8 2.74E7 0.47 0.528 0.9689 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F01 compound treatment 2.47485227E8 9.26E7 1.16 1.20493836E8 -5.11E7 -0.87 0.2035 0.14 3083870 TimTec1_002223 Cc1ccc(NC(=O)Nc2ccc(cc2)C(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F02 compound treatment 1.47414147E8 -7440000.0 -0.09 1.97924406E8 2.64E7 0.45 0.2531 0.5492 3210152 TimTec1_002224 NC(=O)c1sc2NC3=C(C(c2c1N)c4ccc(Cl)cc4)C(=O)c5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F03 compound treatment 1.46286311E8 -8570000.0 -0.11 1.56432067E8 -1.51E7 -0.26 -0.2592 -0.9241 3083874 TimTec1_002225 NC1=C(C#N)C(C(=C(N)O1)C#N)c2cc(Br)cs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F04 compound treatment 2.08202986E8 5.33E7 0.67 1.40972103E8 -3.06E7 -0.52 0.1029 0.1211 1118827 TimTec1_002226 CC(NC(=O)c1ccccc1OCC(=O)NC2(CC3CC4CC(C3)C2)C4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F05 compound treatment 1.73703386E8 1.88E7 0.24 2.12221874E8 4.07E7 0.7 0.6593 0.897 3083876 TimTec1_002227 O=C(COc1ccccc1)N2CCNC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F06 compound treatment 2.27363734E8 7.25E7 0.91 2.13310629E8 4.17E7 0.71 1.1485 0.9929 1468407 TimTec1_002228 NS(=O)(=O)c1ccc(NC(=O)CSc2nnc(c3ccco3)n2CC=C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F07 compound treatment 2.39130988E8 8.43E7 1.06 2.26217526E8 5.47E7 0.94 1.4091 0.9981 3083878 TimTec1_002229 COC(=O)c1ccc(COc2ccccc2Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F08 compound treatment 1.63491385E8 8640000.0 0.11 1.54682307E8 -1.69E7 -0.29 -0.1277 -0.4138 3210153 TimTec1_002230 Nc1cc(=O)[nH]c(=O)n1CC2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F09 compound treatment 1.91957795E8 3.71E7 0.47 1.47952048E8 -2.36E7 -0.4 0.0433 0.0703 3083880 TimTec1_002231 O=C(NC1CCCCCC1)C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F10 compound treatment 2.09591257E8 5.47E7 0.69 1.5142935E8 -2.01E7 -0.34 0.2418 0.3148 1289043 TimTec1_002232 O=C(CSc1nc2ccccc2s1)NCCC3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F11 compound treatment 1.58993471E8 4140000.0 0.05 1.45807577E8 -2.58E7 -0.44 -0.275 -0.6195 1333172 TimTec1_002233 Brc1ccc(cc1)C(=O)Nc2cccc(c2)c3nc4ccccc4o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F12 compound treatment 1.95913653E8 4.11E7 0.52 1.75200185E8 3640000.0 0.06 0.4082 0.7868 1335464 TimTec1_002234 CCn1ccnc1P(=O)(N2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F13 compound treatment 1.49718938E8 -5140000.0 -0.06 1.4205536E8 -2.95E7 -0.51 -0.4027 -0.7909 3083883 TimTec1_002235 CCN(CC)/C=C/1\SC(=S)N(C1=O)c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F14 compound treatment 2.40103564E8 8.52E7 1.07 2.37227E8 6.57E7 1.12 1.551 0.9997 3210154 TimTec1_002236 COc1cc(/C=c/2\sc3=NN=C(C(c4ccccc4)n3\c2=N\CCO)c5ccccc5)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F15 compound treatment 1.45841159E8 -9010000.0 -0.11 2.07486799E8 3.59E7 0.61 0.3549 0.5676 3083885 TimTec1_002237 COc1ccc(NC(=O)CCCOc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F16 compound treatment 2.07550942E8 5.27E7 0.66 1.50924793E8 -2.06E7 -0.35 0.2176 0.2903 3210155 TimTec1_002238 O=C(C(c1ccccc1)c2ccccc2)N3CCNC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F17 compound treatment 1.61145689E8 6290000.0 0.08 1.30631116E8 -4.09E7 -0.7 -0.4396 -0.6235 3210156 TimTec1_002239 Oc1ccc2ccccc2c1/C=N/c3ccc(cc3)S(=O)(=O)N4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F18 compound treatment 2.14798425E8 5.99E7 0.75 1.52466801E8 -1.91E7 -0.33 0.3006 0.3666 3083888 TimTec1_002240 CC(C)(C)c1ccc(cc1)C(=O)n2cc(Cl)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F19 compound treatment 2.10509131E8 5.57E7 0.7 1.7992722E8 8360000.0 0.14 0.5949 0.8347 3210157 TimTec1_002241 Cc1sc(C)c(CNc2ccccc2)c1CNc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F20 compound treatment 2.49947195E8 9.51E7 1.19 1.42309611E8 -2.93E7 -0.5 0.4894 0.3783 3083890 TimTec1_002242 C/C=C/C(=O)c1cc(Cl)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F21 compound treatment 1.52530646E8 -2320000.0 -0.03 1.85822225E8 1.43E7 0.24 0.152 0.6183 3083891 TimTec1_002243 CC(C)c1c(C#N)c(N)nc(SCC(=O)N)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F22 compound treatment 1.70382694E8 1.55E7 0.19 2.23804018E8 5.22E7 0.89 0.7701 0.8414 3210158 TimTec1_002244 CC(C)c1nc2c(Br)cc(Br)cc2c(=S)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F23 mock treatment 1.42814893E8 -1.2E7 -0.15 2.24041179E8 5.25E7 0.9 0.5284 0.5801 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 F24 mock treatment 1.89757294E8 3.49E7 0.44 2.52604928E8 8.1E7 1.39 1.2905 0.8871 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G01 compound treatment 1.56756185E8 1900000.0 0.02 1.58305075E8 -1.33E7 -0.23 -0.1436 -0.6293 3210159 TimTec1_002245 O=C(Nc1ccccc1)Nc2ccccc2C(=O)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G02 compound treatment 1.01850547E8 -5.3E7 -0.66 1.79180027E8 7620000.0 0.13 -0.378 -0.5578 3083894 TimTec1_002246 CC1CCC(CC1)OC(=O)CCC(=O)Nc2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G03 compound treatment 1.68528706E8 1.37E7 0.17 1.12559292E8 -5.9E7 -1.01 -0.5929 -0.5787 1604712 TimTec1_002247 CNC(=O)Nc1ccc(cc1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G04 compound treatment 1.22054098E8 -3.28E7 -0.41 1.29888357E8 -4.17E7 -0.71 -0.7954 -0.9658 3083896 TimTec1_002248 CC(C)Nc1ccc(cc1)n2nc3ccccc3[n+]2[O-] 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G05 compound treatment 1.27985304E8 -2.69E7 -0.34 1.24114106E8 -4.74E7 -0.81 -0.8127 -0.9241 3210160 TimTec1_002249 COc1ccc2nc(sc2c1)/C(=N/O)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G06 compound treatment 1.07953365E8 -4.69E7 -0.59 1.25359151E8 -4.62E7 -0.79 -0.9753 -0.9894 3083961 TimTec1_002250 CC(C)(C)c1ccc(O)c(c1)C(=O)Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G07 compound treatment 1.2250064E8 -3.24E7 -0.41 1.8228168E8 1.07E7 0.18 -0.1572 -0.353 1508878 TimTec1_002251 Cc1ccc(cc1C)C(=O)COC(=O)C2C(C3CC2C=C3)C(=O)OCC(=O)c4ccc(C)c(C)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G08 compound treatment 1.40379002E8 -1.45E7 -0.18 1.20009209E8 -5.16E7 -0.88 -0.7524 -0.8351 1208353 TimTec1_002252 N#Cc1nc(oc1NCCN2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G09 compound treatment 1.00084523E8 -5.48E7 -0.69 1.1828815E8 -5.33E7 -0.91 -1.1307 -0.9903 3210161 TimTec1_002253 CCOc1ccc(/C=C/2\NC(=S)NC2=O)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G10 compound treatment 1.76880952E8 2.2E7 0.28 1.94841209E8 2.33E7 0.4 0.4771 0.984 3083965 TimTec1_002254 O=c/1[nH]\c(=C\c2ccco2)\c(=O)[nH]\c1=C/c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G11 compound treatment 1.82392743E8 2.75E7 0.35 1.77157159E8 5590000.0 0.1 0.312 0.8703 3210162 TimTec1_002255 CCOC(=O)C1=C(C)OC2=C(C1c3ccc(CC)s3)C(=O)CC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G12 compound treatment 1.11460647E8 -4.34E7 -0.54 2.00170383E8 2.86E7 0.49 -0.0386 -0.0528 1549435 TimTec1_002256 OC(=O)CNc1nc(nc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G13 compound treatment 1.86804858E8 3.2E7 0.4 1.28154378E8 -4.34E7 -0.74 -0.242 -0.2867 3210163 TimTec1_002257 Cc1cc(nc2cc(nn12)C(=O)Nc3ccccc3C(F)(F)F)c4ccc(F)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G14 compound treatment 1.15606578E8 -3.92E7 -0.49 1.93256664E8 2.17E7 0.37 -0.0856 -0.1387 3083968 TimTec1_002258 Brc1ccc2ncn(CC=C)c(=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G15 compound treatment 1.30680238E8 -2.42E7 -0.3 1.63519471E8 -8040000.0 -0.14 -0.3118 -0.9362 3210164 TimTec1_002259 O/C(=C/C=N/Cc1ccccc1)/c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G16 compound treatment 1.19559903E8 -3.53E7 -0.44 1.73975518E8 2410000.0 0.04 -0.2839 -0.6384 3083970 TimTec1_002260 CCc1ccc(OCCCC(=O)Nc2nnc[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G17 compound treatment 1.5149047E8 -3360000.0 -0.04 2.01786705E8 3.02E7 0.52 0.336 0.6473 1157670 TimTec1_002261 Fc1ccc(cc1)C(=O)CNc2ccc3c(c2)oc4ccccc43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G18 compound treatment 9.8744637E7 -5.61E7 -0.7 1.5247843E8 -1.91E7 -0.33 -0.7287 -0.9391 1710239 TimTec1_002262 CC(C)c1cccc(C)c1NC(=O)c2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G19 compound treatment 1.18195708E8 -3.67E7 -0.46 1.24863462E8 -4.67E7 -0.8 -0.8904 -0.9655 3210165 TimTec1_002263 S=C(N/C(=N/c1ccccc1)/c2ccccc2)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G20 compound treatment 1.1870666E8 -3.61E7 -0.45 2.01579114E8 3.0E7 0.51 0.0427 0.0623 1693000 TimTec1_002264 CCS(=O)(=O)c1ccc(NC(=O)c2ccccc2)c(O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G21 compound treatment 1.72670428E8 1.78E7 0.22 1.3985625E8 -3.17E7 -0.54 -0.2258 -0.3846 1686276 TimTec1_002265 CCOC(=O)c1cnc2c(C)cc(Cl)cc2c1NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G22 compound treatment 1.07166664E8 -4.77E7 -0.6 1.69778361E8 -1780000.0 -0.03 -0.4446 -0.7423 1208703 TimTec1_002266 CCc1ccc(cc1)C2=CC(C(C#N)C(=O)N2)c3cccc(Br)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G23 mock treatment 1.18971491E8 -3.59E7 -0.45 1.45935887E8 -2.56E7 -0.44 -0.6285 -0.9999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 G24 mock treatment 1.20907189E8 -3.39E7 -0.43 1.8321158E8 1.16E7 0.2 -0.1601 -0.3405 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H01 compound treatment 1.01986433E8 -5.29E7 -0.66 1.78369306E8 6810000.0 0.12 -0.3866 -0.5741 3083974 TimTec1_002267 COc1cccc(NC(=O)Nc2nncs2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H02 compound treatment 8.9919016E7 -6.49E7 -0.81 1.11810389E8 -5.98E7 -1.02 -1.2993 -0.9936 3210281 TimTec1_002268 Cc1ccc(NC(=O)COC(=O)CSc2nnc([nH]2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H03 compound treatment 5.5896682E7 -9.9E7 -1.24 8.4006994E7 -8.76E7 -1.5 -1.9376 -0.9956 3083976 TimTec1_002269 O=c1oc(ns1)c2cc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H04 compound treatment 1.24453577E8 -3.04E7 -0.38 9.0493446E7 -8.11E7 -1.39 -1.2509 -0.8692 3210282 TimTec1_002270 Cc1ccc2c(nc3s/c(=C\c4ccc(o4)c5ccccc5F)/c(=O)n32)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H05 compound treatment 1.79081303E8 2.42E7 0.3 1.05544748E8 -6.6E7 -1.13 -0.5842 -0.4992 3083979 TimTec1_002271 O=C(CSc1ccccn1)NC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H06 compound treatment 1.47470397E8 -7380000.0 -0.09 1.23334363E8 -4.82E7 -0.83 -0.6493 -0.7815 1698408 TimTec1_002272 NC(=O)C1C(=NC(=C(C#N)C21CCCCC2)N)SCC(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H07 compound treatment 9.3088029E7 -6.18E7 -0.77 1.12115115E8 -5.94E7 -1.02 -1.2675 -0.9909 3083981 TimTec1_002273 COc1ccccc1/C=C/C(=O)Nc2sc3CCCc3c2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H08 compound treatment 1.12893365E8 -4.2E7 -0.53 1.25170087E8 -4.64E7 -0.79 -0.9338 -0.9801 1633716 TimTec1_002274 CC1CCN(CC1)C(=O)c2scc3CCCCc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H09 compound treatment 1.38236078E8 -1.66E7 -0.21 1.29683718E8 -4.19E7 -0.72 -0.6543 -0.8764 1434772 TimTec1_002275 Cc1cccc(NC(=O)c2cccc(Br)c2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H10 compound treatment 1.15608265E8 -3.92E7 -0.49 1.05287175E8 -6.63E7 -1.13 -1.1503 -0.9302 1459322 TimTec1_002276 COC(=O)c1ccc2CN(Cc2c1)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H11 compound treatment 1.15821514E8 -3.9E7 -0.49 1.5505403E8 -1.65E7 -0.28 -0.5461 -0.9659 1227803 TimTec1_002277 CC(=O)Oc1ccc(cc1)C(C)(C)c2ccc(OC(=O)C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H12 compound treatment 1.15834129E8 -3.9E7 -0.49 1.11560632E8 -6.0E7 -1.03 -1.0724 -0.9425 1246806 TimTec1_002278 O=C(COc1ccccc1)Nc2ccc(cc2)S(=O)(=O)Nc3ncccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H13 compound treatment 1.45849492E8 -9000000.0 -0.11 1.15149578E8 -5.64E7 -0.97 -0.7627 -0.7845 3210283 TimTec1_002279 C[C@@H](N1C[C@@H](CO)OC1=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H14 compound treatment 1.48921324E8 -5930000.0 -0.07 1.40249573E8 -3.13E7 -0.54 -0.4317 -0.7976 1334040 TimTec1_002280 OC(=O)CCN1CCn2c3C1CCCc3c4cc(ccc24)C5CCCCC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H15 compound treatment 1.31353239E8 -2.35E7 -0.29 1.231966E8 -4.84E7 -0.83 -0.7939 -0.9033 3084053 TimTec1_002281 CCCNC(=O)N(C)Cc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H16 compound treatment 1.49398681E8 -5460000.0 -0.07 1.29606505E8 -4.2E7 -0.72 -0.5562 -0.771 1566880 TimTec1_002282 CCOc1ccc(NC(=O)Cc2ccccc2OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H17 compound treatment 1.24414344E8 -3.04E7 -0.38 1.00241103E8 -7.13E7 -1.22 -1.1333 -0.8859 1399838 TimTec1_002283 CC(C)N1C(n2oc(=O)n(c3cccc(Cl)c3)c2=O)C(C)(C)SC1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H18 compound treatment 1.59679575E8 4830000.0 0.06 1.38376563E8 -3.32E7 -0.57 -0.3589 -0.6282 3084055 TimTec1_002284 Cc1ccccc1C(=O)n2cc(Cl)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H19 compound treatment 7.7031739E7 -7.78E7 -0.98 1.78337727E8 6770000.0 0.12 -0.6083 -0.6188 3210284 TimTec1_002285 CCSc1nnc2n(/N=C/c3cccs3)cnn12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H20 compound treatment 1.1421609E8 -4.06E7 -0.51 1.59720998E8 -1.18E7 -0.2 -0.5038 -0.9183 3210285 TimTec1_002286 O=C(CSc1nnc(c2ccccc2)n1c3ccccc3)NC4CC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H21 compound treatment 1.38391766E8 -1.65E7 -0.21 1.03901179E8 -6.77E7 -1.16 -0.965 -0.8202 1379455 TimTec1_002287 NS(=O)(=O)c1ccc(NC(=O)COC(=O)c2cccc(c2)N3C(=O)CCC3=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H22 compound treatment 1.3535279E8 -1.95E7 -0.24 1.09388466E8 -6.22E7 -1.06 -0.9256 -0.8475 3210286 TimTec1_002288 CC(Sc1ccc(Cl)cc1)C(=O)NCc2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H23 mock treatment 1.10107965E8 -4.47E7 -0.56 1.8246409E8 1.09E7 0.19 -0.265 -0.4479 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 H24 mock treatment 1.81486145E8 2.66E7 0.33 1.78610296E8 7050000.0 0.12 0.3215 0.9052 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I01 compound treatment 1.71883719E8 1.7E7 0.21 1.76755856E8 5190000.0 0.09 0.2139 0.9245 3084057 TimTec1_002289 COC(=O)c1ccc(NC(=S)N2CCOCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I02 compound treatment 1.71139601E8 1.63E7 0.2 1.77040092E8 5480000.0 0.09 0.2107 0.9376 3210287 TimTec1_002290 CCOc1ccc(NC(=O)C2CC=CCC2C(=O)OC(C)CC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I03 compound treatment 1.66378276E8 1.15E7 0.14 1.72046417E8 483000.0 0.01 0.1081 0.7463 1638709 TimTec1_002291 CNC(=O)Nc1ccc(cc1)C(=O)NC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I04 compound treatment 1.53317611E8 -1540000.0 -0.02 1.5070964E8 -2.09E7 -0.36 -0.266 -0.7442 1005018 TimTec1_002292 Oc1ccc(Cl)cc1Sc2cc(Cl)ccc2O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I05 compound treatment 1.93531529E8 3.87E7 0.49 1.75518245E8 3950000.0 0.07 0.391 0.798 3210288 TimTec1_002293 Cc1cccc2c(O)c(/C=C/3\C(NN(C3=O)c4ccccc4)c5ccccc5)c(=O)[nH]c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I06 compound treatment 1.75379985E8 2.05E7 0.26 1.76789219E8 5230000.0 0.09 0.2453 0.9 1025812 TimTec1_002294 CNC(=O)c1ccc(N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I07 compound treatment 2.08129687E8 5.33E7 0.67 1.8688528E8 1.53E7 0.26 0.658 0.9166 3210289 TimTec1_002295 O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)/C=C/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I08 compound treatment 1.78374214E8 2.35E7 0.3 1.70906859E8 -656000.0 -0.01 0.2007 0.6797 1738195 TimTec1_002296 Cc1ccc(cc1)N(C(=O)COc2c(C)cccc2C)S(=O)(=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I09 compound treatment 1.67569425E8 1.27E7 0.16 1.77674435E8 6110000.0 0.1 0.1868 0.9791 3210290 TimTec1_002297 O=C/1NC(=S)S\C1=C\c2ccc(o2)c3ccc4C(=O)NC(=O)c4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I10 compound treatment 1.92333432E8 3.75E7 0.47 1.78385817E8 6820000.0 0.12 0.415 0.8567 3084063 TimTec1_002298 Nc1cc(O)n(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I11 compound treatment 1.75534046E8 2.07E7 0.26 4.4621128E7 -1.27E8 -2.17 -1.3531 -0.6183 3210291 TimTec1_002299 CC(=C)C(=O)OCCc1ccc(O)c(c1)n2nc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I12 compound treatment 1.3411261E8 -2.07E7 -0.26 1.77138922E8 5580000.0 0.1 -0.1165 -0.4203 1195244 TimTec1_002300 Cc1cc(Nc2ccc(Cl)cc2)c3ccccc3n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I13 compound treatment 1.39938917E8 -1.49E7 -0.19 1.64554131E8 -7010000.0 -0.12 -0.2171 -0.9769 3210292 TimTec1_002301 FC(F)(F)c1ccccc1CN2CCN(CC3CC4CC3C=C4)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I14 compound treatment 1.64993779E8 1.01E7 0.13 2.03373686E8 3.18E7 0.54 0.475 0.8494 1020410 TimTec1_002302 Nc1ccc(cc1)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I15 compound treatment 1.97392325E8 4.25E7 0.53 1.95922332E8 2.44E7 0.42 0.6722 0.9926 1667680 TimTec1_002303 CC(Sc1nc(C)c(Oc2ccccc2)c(O)n1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I16 compound treatment 1.77225799E8 2.24E7 0.28 2.14876671E8 4.33E7 0.74 0.7227 0.9116 3084067 TimTec1_002304 Cc1ccc(OCc2ccc(Cl)cc2)c(c1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I17 compound treatment 2.04551357E8 4.97E7 0.62 1.80659436E8 9100000.0 0.16 0.5509 0.8574 1430919 TimTec1_002305 Cc1nonc1N(Cc2ccc(F)cc2)S(=O)(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I18 compound treatment 1.69006293E8 1.42E7 0.18 1.7931864E8 7760000.0 0.13 0.2194 0.9897 3210293 TimTec1_002306 O=C(CCCOc1ccccc1)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I19 compound treatment 1.64709067E8 9850000.0 0.12 1.94840336E8 2.33E7 0.4 0.3692 0.8849 1603996 TimTec1_002307 N#Cc1nc(oc1N2CCCCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I20 compound treatment 1.63090799E8 8240000.0 0.1 1.84240926E8 1.27E7 0.22 0.2265 0.9424 1030356 TimTec1_002308 O=C(Nc1ccccc1)Nc2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I21 compound treatment 1.60792898E8 5940000.0 0.07 1.69139995E8 -2420000.0 -0.04 0.0233 0.2738 3210294 TimTec1_002309 CCOC(=O)c1cnc2ccc(OCC)cc2c1NCCCN3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I22 compound treatment 1.77566771E8 2.27E7 0.28 1.77528983E8 5970000.0 0.1 0.2737 0.9042 3084138 TimTec1_002310 Cc1cccc(CC2(Cc3cccc(C)c3)C(=O)OC(C)(C)OC2=O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I23 mock treatment 1.72558299E8 1.77E7 0.22 1.7353257E8 1970000.0 0.03 0.1809 0.8052 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 I24 mock treatment 1.66021478E8 1.12E7 0.14 1.83130771E8 1.16E7 0.2 0.2391 0.9856 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J01 compound treatment 1.70029465E8 1.52E7 0.19 1.88095104E8 1.65E7 0.28 0.3347 0.9814 3210295 TimTec1_002311 Clc1cccc(NC(=O)Nc2nncs2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J02 compound treatment 1.76213318E8 2.14E7 0.27 1.90198327E8 1.86E7 0.32 0.415 0.9962 3210296 TimTec1_002312 CCN1/C(=c\2/sc3nc4ccccc4n3c2=O)/Sc5ccc(OC)cc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J03 compound treatment 1.07242876E8 -4.76E7 -0.6 8.3953143E7 -8.76E7 -1.5 -1.4828 -0.9185 3084141 TimTec1_002313 O=c1oc(ns1)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J04 compound treatment 1.9754932E8 4.27E7 0.54 1.69414179E8 -2150000.0 -0.04 0.3527 0.657 1542017 TimTec1_002314 CCOC(=O)C1C(C(C(=O)OCC)C(=O)CC1=O)c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J05 compound treatment 1.74292324E8 1.94E7 0.24 1.99256469E8 2.77E7 0.47 0.5076 0.9522 3084143 TimTec1_002315 N=C1SCC(=O)N1C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J06 compound treatment 1.88252988E8 3.34E7 0.42 2.03240448E8 3.17E7 0.54 0.6797 0.9919 1449538 TimTec1_002316 O=C(NCc1cccnc1)NC2(CC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J07 compound treatment 1.99223175E8 4.44E7 0.56 2.10774703E8 3.92E7 0.67 0.8682 0.9957 3084144 TimTec1_002317 N/C(=N\O)/c1ccc(NC(=O)c2ccccn2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J08 compound treatment 1.94268843E8 3.94E7 0.49 2.0098439E8 2.94E7 0.5 0.7057 1.0 1594153 TimTec1_002318 CN(C)c1nc(F)c(F)c(c1F)S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J09 compound treatment 1.84066333E8 2.92E7 0.37 1.61549631E8 -1.0E7 -0.17 0.1379 0.3409 1187969 TimTec1_002319 Cn1cc(Cl)c(n1)C(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J10 compound treatment 1.81613625E8 2.68E7 0.34 2.24802222E8 5.32E7 0.91 0.8818 0.9079 1126252 TimTec1_002320 CC(C)OC1(O)C(=O)c2ccccc2C(=O)C1(O)OC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J11 compound treatment 1.76887975E8 2.2E7 0.28 2.14155646E8 4.26E7 0.73 0.711 0.9118 1344052 TimTec1_002321 Cc1ccc(cc1)S(=O)(=O)Nc2c[nH]c(=O)[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J12 compound treatment 1.29250384E8 -2.56E7 -0.32 2.00948147E8 2.94E7 0.5 0.1286 0.2154 1290298 TimTec1_002322 O=C(Nc1nccs1)c2ccccc2C(=O)Nc3nccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J13 compound treatment 1.65218342E8 1.04E7 0.13 1.826996E8 1.11E7 0.19 0.2267 0.9826 1039552 TimTec1_002323 CCC(N)Cc1c[nH]c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J14 compound treatment 1.42775363E8 -1.21E7 -0.15 1.48667032E8 -2.29E7 -0.39 -0.3843 -0.9145 1270186 TimTec1_002324 O=C(Oc1nsnc1N2CCOCC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J15 compound treatment 1.65786592E8 1.09E7 0.14 1.92225589E8 2.07E7 0.35 0.3471 0.9149 1075811 TimTec1_002325 CCN(C(=O)c1ccc(cc1)C(=O)N(CC)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J16 compound treatment 1.8789552E8 3.3E7 0.41 2.11246891E8 3.97E7 0.68 0.7734 0.9719 3084150 TimTec1_002326 CCOc1ccc(NC(=O)CCc2ccc(OC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J17 compound treatment 1.95263284E8 4.04E7 0.51 2.1437959E8 4.28E7 0.73 0.8767 0.9838 3210404 TimTec1_002327 CC(C)(C)C(=O)CSc1nc(N)c(C#N)c(c2cccs2)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J18 compound treatment 1.77078724E8 2.22E7 0.28 2.00264835E8 2.87E7 0.49 0.5445 0.964 1921516 TimTec1_002328 Cc1cc(C)n(n1)C(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J19 compound treatment 1.67484421E8 1.26E7 0.16 1.85440891E8 1.39E7 0.24 0.28 0.9806 1585601 TimTec1_002329 COc1ccc(NC(=O)C2(C)c3ccccc3-c4ccccc42)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J20 compound treatment 1.50075521E8 -4780000.0 -0.06 1.90337121E8 1.88E7 0.32 0.1849 0.5655 1485338 TimTec1_002330 Cc1ccn2cc(nc2c1)c3ccc(O)c(O)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J21 compound treatment 1.7309141E8 1.82E7 0.23 2.01266636E8 2.97E7 0.51 0.5213 0.935 3210405 TimTec1_002331 S=P(c1ccccc1)(c2ccccc2)C3(CCCC3)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J22 compound treatment 1.83060322E8 2.82E7 0.35 1.80492342E8 8930000.0 0.15 0.3583 0.9295 3084154 TimTec1_002332 CN(C)/C=N/c1nnc(s1)N2CCN(CC2)c3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J23 mock treatment 1.44057254E8 -1.08E7 -0.14 1.74331932E8 2770000.0 0.05 -0.0623 -0.4339 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 J24 mock treatment 1.55640396E8 786000.0 0.01 1.9729557E8 2.57E7 0.44 0.3184 0.7228 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K01 compound treatment 1.66727968E8 1.19E7 0.15 1.51238746E8 -2.03E7 -0.35 -0.1407 -0.3717 3210406 TimTec1_002333 COC(=O)c1ccccc1NC(=S)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K02 compound treatment 1.72689994E8 1.78E7 0.22 1.68711748E8 -2850000.0 -0.05 0.1237 0.5401 3210407 TimTec1_002334 CCC(C)OC(=O)C1CC=CCC1C(=O)Nc2cccc(Br)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K03 compound treatment 1.89737966E8 3.49E7 0.44 1.36316486E8 -3.52E7 -0.6 -0.1172 -0.1572 3084226 TimTec1_002335 CC(C)(C)Sc1cccc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K04 compound treatment 1.88018318E8 3.32E7 0.42 1.56942173E8 -1.46E7 -0.25 0.1172 0.2414 3084228 TimTec1_002336 CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(=O)C(C)(C)NO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K05 compound treatment 1.14624263E8 -4.02E7 -0.5 9.3504638E7 -7.81E7 -1.34 -1.3017 -0.9113 3210408 TimTec1_002337 C/C(=C/C(=O)c1c(O)c2ccccc2n(C)c1=O)/Nc3ccc(N)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K06 compound treatment 1.88337179E8 3.35E7 0.42 1.66136518E8 -5430000.0 -0.09 0.2313 0.5377 1115526 TimTec1_002338 COC(=O)c1ccc(NC(=O)Nc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K07 compound treatment 1.37207069E8 -1.76E7 -0.22 1.51812735E8 -1.98E7 -0.34 -0.3956 -0.9789 1577631 TimTec1_002339 COc1cc(cc(OC)c1OC)C(=O)C(C#N)c2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K08 compound treatment 1.97451118E8 4.26E7 0.53 1.14977738E8 -5.66E7 -0.97 -0.3071 -0.2776 1662490 TimTec1_002340 COc1ccc(cc1)N(C(=O)c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K09 compound treatment 1.22830368E8 -3.2E7 -0.4 9.8927E7 -7.26E7 -1.24 -1.1633 -0.8903 3210409 TimTec1_002341 CC/1=NN(C(=O)\C1=C/c2ccc(o2)c3ccc(cc3)S(=O)(=O)N)c4ccc(C)c(C)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K10 compound treatment 3.51679355E8 1.97E8 2.47 2.3024322E8 5.87E7 1.0 2.4562 0.9214 3084233 TimTec1_002342 Cc1ccc2nc(sc2c1)c3ccc(/N=C/c4c[nH]c5ccccc45)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K11 compound treatment 1.62155445E8 7300000.0 0.09 1.80781718E8 9220000.0 0.16 0.1763 0.9665 1879124 TimTec1_002343 C(/C=C/c1ccccc1)N2CCNCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K12 compound treatment 1.47073007E8 -7780000.0 -0.1 1.54939284E8 -1.66E7 -0.28 -0.2702 -0.8983 1460330 TimTec1_002344 Cc1cc(NCc2ccco2)c3ccccc3n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K13 compound treatment 1.60454925E8 5600000.0 0.07 1.87468059E8 1.59E7 0.27 0.2422 0.8614 3210411 TimTec1_002345 COc1ccc(NC(=O)C2CCCCN2/N=C/c3ccc(OC)c(OCC(C)C)c3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K14 compound treatment 1.53277328E8 -1580000.0 -0.02 1.46226003E8 -2.53E7 -0.43 -0.3207 -0.7386 1358271 TimTec1_002346 O=C(N1CCCc2ccccc12)c3cc4ccccc4o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K15 compound treatment 2.03308591E8 4.85E7 0.61 1.88859571E8 1.73E7 0.3 0.6392 0.9454 1526938 TimTec1_002347 CC1(C2C(C=CC1c3ccccc3)c4ccccc4)C(=O)N(CCC5=CCCCC5)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K16 compound treatment 1.72282741E8 1.74E7 0.22 2.01097768E8 2.95E7 0.51 0.5121 0.9297 1395232 TimTec1_002348 CC(C)(C)c1ccc(OCC(=O)NC(c2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K17 compound treatment 1.23376867E8 -3.15E7 -0.39 2.13651252E8 4.21E7 0.72 0.2302 0.2802 3210412 TimTec1_002349 O=C(Cc1ccccc1)Oc2ccc(/N=C/c3cccs3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K18 compound treatment 2.07540891E8 5.27E7 0.66 1.34033311E8 -3.75E7 -0.64 0.0131 0.0142 3084236 TimTec1_002350 CC(C)c1cccc(C(C)C)c1NC(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K19 compound treatment 1.29460468E8 -2.54E7 -0.32 1.3343655E8 -3.81E7 -0.65 -0.6867 -0.9456 3210413 TimTec1_002351 OC(CN1C(=O)S/C(=C/c2ccccc2)/C1=O)Cn3c4ccccc4c5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K20 compound treatment 1.70036924E8 1.52E7 0.19 1.98103884E8 2.65E7 0.45 0.4559 0.9255 3084237 TimTec1_002352 Cc1ccccc1OCCCC(=O)Nc2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K21 compound treatment 1.38772989E8 -1.61E7 -0.2 1.30169296E8 -4.14E7 -0.71 -0.6437 -0.8737 3210414 TimTec1_002353 CC(Sc1ncnc2sc3CCCCc3c12)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K22 compound treatment 1.88744042E8 3.39E7 0.43 1.34500907E8 -3.71E7 -0.63 -0.148 -0.1938 1464155 TimTec1_002354 CC1=CC(C)(C)N(C(=O)c2ccccc2)c3ccc(OC(=O)c4ccccc4)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K23 mock treatment 1.22663318E8 -3.22E7 -0.4 1.54879034E8 -1.67E7 -0.29 -0.4875 -0.9856 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 K24 mock treatment 1.8821137E8 3.34E7 0.42 1.41986468E8 -2.96E7 -0.51 -0.0621 -0.0946 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L01 compound treatment 1.28025168E8 -2.68E7 -0.34 1.67490042E8 -4070000.0 -0.07 -0.2873 -0.8359 3210415 TimTec1_002355 Cc1cc(NC(=O)NC(C)(C)C)no1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L02 compound treatment 1.26938384E8 -2.79E7 -0.35 1.54737723E8 -1.68E7 -0.29 -0.4513 -0.9953 3084239 TimTec1_002356 CC1CCN(CC1)C(=O)/C=C\c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L03 compound treatment 8.4463208E7 -7.04E7 -0.88 9.9692782E7 -7.19E7 -1.23 -1.4943 -0.9868 3210416 TimTec1_002357 CC(=O)Nc1sc2CCCCc2c1c3nsc(=O)o3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L04 compound treatment 1.54536344E8 -318000.0 0.0 1.57568969E8 -1.4E7 -0.24 -0.1722 -0.7188 1127427 TimTec1_002358 CC(C)(C)NC(=O)Cn1c(nc2ccccc12)c3nonc3N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L05 compound treatment 1.37379963E8 -1.75E7 -0.22 1.69405721E8 -2160000.0 -0.04 -0.1811 -0.8148 3084242 TimTec1_002359 O=c1[nH]cc(Sc2cccc3cccnc23)c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L06 compound treatment 1.16544322E8 -3.83E7 -0.48 1.37895386E8 -3.37E7 -0.58 -0.7473 -0.9959 1461401 TimTec1_002360 CC1(O)N(Cc2ccccn2)C(=O)OC31CC(C)(C)NC(C)(C)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L07 compound treatment 1.12075416E8 -4.28E7 -0.54 1.65790649E8 -5770000.0 -0.1 -0.4493 -0.8235 3084243 TimTec1_002361 OC(=O)C1CSC(N1)C2CCC=CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L08 compound treatment 1.70829784E8 1.6E7 0.2 1.50859108E8 -2.07E7 -0.35 -0.1089 -0.2675 1709669 TimTec1_002362 O=C(CSc1nc2ccccc2o1)NCC3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L09 compound treatment 1.24433705E8 -3.04E7 -0.38 1.62424508E8 -9140000.0 -0.16 -0.3805 -0.9225 3084245 TimTec1_002363 Brc1cnn(c1)C(=O)COc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L10 compound treatment 1.17207877E8 -3.76E7 -0.47 1.67267286E8 -4300000.0 -0.07 -0.3859 -0.8075 3210417 TimTec1_002364 Cc1ccc(/C=N/N2C(=O)C3C4C=CC(C3C2=O)C54CC5)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L11 compound treatment 1.12063736E8 -4.28E7 -0.54 1.43472094E8 -2.81E7 -0.48 -0.7196 -0.9985 1712043 TimTec1_002365 O=C(Nc1cccc(c1)c2nc3ccccc3[nH]2)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L12 compound treatment 1.13307317E8 -4.15E7 -0.52 1.7494222E8 3380000.0 0.06 -0.3276 -0.6248 1574585 TimTec1_002366 O=C(Nc1ccc(cc1)S(=O)(=O)Nc2nccs2)c3cc4ccccc4oc3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L13 compound treatment 1.0900945E8 -4.58E7 -0.58 1.50311345E8 -2.13E7 -0.36 -0.6639 -0.9756 3423047 TimTec1_002367 NNC(=O)CCCCC1SCC2NC(=O)NC12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L14 compound treatment 1.83791072E8 2.89E7 0.36 1.58372584E8 -1.32E7 -0.23 0.097 0.2269 1216605 TimTec1_002368 Oc1ccc2ccccc2c1CN3CCN(Cc4ccc5OCOc5c4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L15 compound treatment 1.60594857E8 5740000.0 0.07 2.41100034E8 6.95E7 1.19 0.8926 0.7485 1280719 TimTec1_002369 CCN(Cc1ccccc1)C(=O)c2ccc(cc2)C(=O)N(CC)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L16 compound treatment 1.66302105E8 1.14E7 0.14 2.38761682E8 6.72E7 1.15 0.9149 0.7893 3084319 TimTec1_002370 COC(=O)c1ccccc1NC(=O)CCc2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L17 compound treatment 1.01386905E8 -5.35E7 -0.67 1.37924378E8 -3.36E7 -0.58 -0.8814 -0.9971 1598426 TimTec1_002371 CC(C)(C)Nc1nc(Cl)nc(n1)N(CN2C(=O)c3ccccc3S2(=O)=O)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L18 compound treatment 1.56215299E8 1360000.0 0.02 1.342686E8 -3.73E7 -0.64 -0.4393 -0.6879 3084321 TimTec1_002372 Fc1ccc(cc1)C(=O)n2cc(Cl)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L19 compound treatment 2.72924417E8 1.18E8 1.48 1.91824149E8 2.03E7 0.35 1.2926 0.8497 3210418 TimTec1_002373 COc1ccc(OC)c(/C=N/N2C(=O)C3C4C=CC(C3C2=O)C54CC5)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L20 compound treatment 1.18240474E8 -3.66E7 -0.46 2.29042137E8 5.75E7 0.98 0.371 0.3416 1442776 TimTec1_002374 O=S(=O)(Nc1ccc2OC3(CCCCC3)Oc2c1)c4ccc5ccccc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L21 compound treatment 1.79900609E8 2.5E7 0.31 1.36599305E8 -3.5E7 -0.6 -0.201 -0.2974 1471128 TimTec1_002375 CS(=O)(=O)C1=C(N)C(=O)N(C1c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L22 compound treatment 1.69835626E8 1.5E7 0.19 1.30482175E8 -4.11E7 -0.7 -0.3644 -0.5006 3210419 TimTec1_002376 CC/N=C/1\S/C(=C\c2cn(nc2c3ccccc3)C(=O)C)/C(=O)N1CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L23 mock treatment 1.88003447E8 3.31E7 0.42 1.6326043E8 -8300000.0 -0.14 0.1935 0.4404 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 L24 mock treatment 1.6325587E8 8400000.0 0.11 1.6218304E8 -9380000.0 -0.16 -0.039 -0.2031 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M01 compound treatment 1.64187208E8 9330000.0 0.12 1.58222035E8 -1.33E7 -0.23 -0.0787 -0.3067 3084325 TimTec1_002377 COC(=O)c1ccccc1NC(=S)Nc2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M02 compound treatment 1.73258187E8 1.84E7 0.23 1.67506014E8 -4060000.0 -0.07 0.1141 0.4734 3210420 TimTec1_002378 CC(=O)Nc1ccc(NC(=O)C2CC=CCC2C(=O)OCC=C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M03 compound treatment 1.70358326E8 1.55E7 0.19 1.85091747E8 1.35E7 0.23 0.3013 0.9962 1268388 TimTec1_002379 CC(C)(C)S(=O)(=O)c1ccc(cc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M04 compound treatment 1.85685461E8 3.08E7 0.39 1.75718281E8 4150000.0 0.07 0.3238 0.8233 1008465 TimTec1_002380 CC(C)(c1ccccc1)c2ccc(O)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M05 compound treatment 2.10977881E8 5.61E7 0.7 1.83831059E8 1.23E7 0.21 0.6463 0.8797 3210421 TimTec1_002381 Cn1c(=O)c(C(=O)/C=C/C=C/c2ccccc2)c(O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M06 compound treatment 2.03889181E8 4.9E7 0.62 1.90576545E8 1.9E7 0.33 0.6651 0.9557 1115325 TimTec1_002382 CC(=O)Nc1ccc(cc1)C(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M07 compound treatment 1.8545902E8 3.06E7 0.38 1.81566195E8 1.0E7 0.17 0.3926 0.9338 3084329 TimTec1_002383 COc1cccc(OCCSc2nc3ccccc3s2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M08 compound treatment 1.85998233E8 3.11E7 0.39 2.0163098E8 3.01E7 0.51 0.6402 0.9907 1718621 TimTec1_002384 COc1ccc(cc1)N(C(=O)C)S(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M09 compound treatment 1.92915842E8 3.81E7 0.48 1.74928488E8 3370000.0 0.06 0.3784 0.7867 3210534 TimTec1_002385 CCOC(=O)c1ccc(cc1)N2N=C(/C(=C/c3ccc(OCC)c(OCC)c3)/C2=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M10 compound treatment 1.70556948E8 1.57E7 0.2 2.09939978E8 3.84E7 0.66 0.6038 0.8804 3084332 TimTec1_002386 NC(=O)c1ccccc1/N=C/c2ccc(Br)s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M11 compound treatment 1.66952621E8 1.21E7 0.15 2.13767352E8 4.22E7 0.72 0.6182 0.8374 3084333 TimTec1_002387 CC(C)c1cc[nH]c1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M12 compound treatment 1.50595785E8 -4260000.0 -0.05 1.79850316E8 8290000.0 0.14 0.0625 0.4126 1512531 TimTec1_002388 Cc1cccc(Oc2cc(C)nc3ccc(C)cc23)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M13 compound treatment 8.1779753E7 -7.31E7 -0.92 2.25741502E8 5.42E7 0.93 0.0076 0.0058 3084336 TimTec1_002389 CCOC(=O)C(C)Sc1nc(N)nc(SC)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M14 compound treatment 1.65593048E8 1.07E7 0.13 2.29236015E8 5.77E7 0.99 0.7933 0.7962 3210535 TimTec1_002390 CS(=O)(=O)Nc1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M15 compound treatment 8.6424705E7 -6.84E7 -0.86 1.98686666E8 2.71E7 0.46 -0.2787 -0.2856 1144104 TimTec1_002391 CC1OS(=O)OC1(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M16 compound treatment 1.58745667E8 3890000.0 0.05 1.91452428E8 1.99E7 0.34 0.2753 0.8003 1527653 TimTec1_002392 CCCOC(=O)Nc1ccc(Cl)cc1C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M17 compound treatment 1.97267116E8 4.24E7 0.53 2.15545367E8 4.4E7 0.75 0.9086 0.9856 3083234 TimTec1_002393 Cc1ccc(cc1)C(=O)Oc2ccc(/C=N/c3cccs3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M18 compound treatment 1.74241164E8 1.94E7 0.24 2.15233612E8 4.37E7 0.75 0.7006 0.8912 1460929 TimTec1_002394 Cn1nccc1C(=O)NCCN2C(=O)OC3(CCCCC3)C2(C)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M19 compound treatment 1.23013753E8 -3.18E7 -0.4 2.37733888E8 6.62E7 1.13 0.5185 0.4317 3083237 TimTec1_002395 Nc1c(n[nH]c1c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M20 compound treatment 1.64719234E8 9870000.0 0.12 1.95519854E8 2.4E7 0.41 0.3775 0.8812 3210536 TimTec1_002396 CCc1ccc(OCCCC(=O)NCc2ccco2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M21 compound treatment 1.76992992E8 2.21E7 0.28 2.2274549E8 5.12E7 0.88 0.8159 0.8877 3083239 TimTec1_002397 Oc1ccc(Br)cc1/C=N\S(=O)(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M22 compound treatment 1.55782607E8 928000.0 0.01 2.19365876E8 4.78E7 0.82 0.5868 0.7171 1432671 TimTec1_002398 O=C(C(Sc1ccccc1)c2ccccc2)N3CCCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M23 mock treatment 1.53907702E8 -946000.0 -0.01 2.30793133E8 5.92E7 1.01 0.7085 0.6988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 M24 mock treatment 1.84486444E8 2.96E7 0.37 2.0407475E8 3.25E7 0.56 0.6564 0.9808 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N01 compound treatment 1.97005037E8 4.22E7 0.53 2.0778735E8 3.62E7 0.62 0.8124 0.9969 3083240 TimTec1_002399 Cc1csc(NC(=O)NC(C)(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N02 compound treatment 1.57576304E8 2720000.0 0.03 2.06431123E8 3.49E7 0.6 0.4462 0.7463 3210537 TimTec1_002400 FC(F)(F)c1ccc(cc1)C(=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N03 compound treatment 1.03166138E8 -5.17E7 -0.65 2.15072838E8 4.35E7 0.74 0.0682 0.069 3210538 TimTec1_002401 CSc1nsc(SCc2ccc(cc2)C(=O)Nc3ccc(Cl)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N04 compound treatment 2.01018028E8 4.62E7 0.58 1.39142233E8 -3.24E7 -0.55 0.0171 0.0213 1438663 TimTec1_002402 COC(=O)c1sc(C(=O)OC)c2OCCOc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N05 compound treatment 1.64104225E8 9250000.0 0.12 1.40249389E8 -3.13E7 -0.54 -0.297 -0.5415 1361986 TimTec1_002403 O=C(Nc1nc2ccccc2s1)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N06 compound treatment 1.83472757E8 2.86E7 0.36 2.07922313E8 3.64E7 0.62 0.694 0.9658 1212434 TimTec1_002404 O=C(NC1(CC2CC3CC(C2)C1)C3)C4CCCN4S(=O)(=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N07 compound treatment 1.92785677E8 3.79E7 0.48 1.57392994E8 -1.42E7 -0.24 0.1649 0.3088 3083244 TimTec1_002405 CC(C1NC(CS1)C(=O)O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N08 compound treatment 2.06395861E8 5.15E7 0.65 2.32130562E8 6.06E7 1.04 1.1903 0.9742 1224464 TimTec1_002406 COc1ccccc1CN(C2CC(C)(C)N(C(=O)C)C(C)(C)C2)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N09 compound treatment 1.9104386E8 3.62E7 0.45 1.03235111E8 -6.83E7 -1.17 -0.506 -0.4033 1304876 TimTec1_002407 Oc1ccccc1NC(=O)c2cc(NC(=O)c3ccccc3)cc(c2)C(=O)Nc4ccccc4O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N10 compound treatment 1.76507729E8 2.17E7 0.27 1.50165696E8 -2.14E7 -0.37 -0.0669 -0.1468 1473339 TimTec1_002408 Brc1cccc(Cn2ccc(NC3CCCC3)nc2=O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N11 compound treatment 1.60329578E8 5480000.0 0.07 1.43854849E8 -2.77E7 -0.47 -0.2868 -0.5985 1341588 TimTec1_002409 O=C(COc1ccccc1)Nc2nccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N12 compound treatment 8.4463893E7 -7.04E7 -0.88 1.7636937E8 4810000.0 0.08 -0.5662 -0.6385 1327761 TimTec1_002410 Cc1ccc2nc(NC(=O)C3CC(O)CN3C(=O)Oc4ccccc4)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N13 compound treatment 9.3158994E7 -6.17E7 -0.77 2.08571067E8 3.7E7 0.63 -0.0993 -0.0993 3210539 TimTec1_002411 CCN(CC)c1ccc(/N=C/c2cc(C)n(c2C)c3ccc(OC(=O)C)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N14 compound treatment 1.7312863E8 1.83E7 0.23 1.74086438E8 2520000.0 0.04 0.1926 0.8258 1381502 TimTec1_002412 Cn1c(CSc2nc3ccccc3s2)nnc1SCC(=O)NCCO 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N15 compound treatment 1.70620249E8 1.58E7 0.2 2.37016237E8 6.55E7 1.12 0.9321 0.8193 1470780 TimTec1_002413 O=C(N1CCc2ccccc2C1)c3ccc(cc3)C(=O)N4CCc5ccccc5C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N16 compound treatment 7.3714433E7 -8.11E7 -1.02 1.65470979E8 -6090000.0 -0.1 -0.7935 -0.7755 3083248 TimTec1_002414 COC(=O)c1sc(NC(=O)c2ccccc2)c(C(=O)OC)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N17 compound treatment 1.62743014E8 7890000.0 0.1 1.44010785E8 -2.76E7 -0.47 -0.2635 -0.5468 1663793 TimTec1_002415 Cc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccc(C)n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N18 compound treatment 1.49683297E8 -5170000.0 -0.06 2.20919592E8 4.94E7 0.84 0.5516 0.6509 3083249 TimTec1_002416 COc1ccc(/C=N/c2nonc2N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N19 compound treatment 1.64330318E8 9480000.0 0.12 2.35660324E8 6.41E7 1.1 0.8599 0.7792 1431956 TimTec1_002417 O=C(Nn1nnnc1Nc2ccccc2)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N20 compound treatment 1.65555938E8 1.07E7 0.13 2.2821957E8 5.67E7 0.97 0.7807 0.7974 3210540 TimTec1_002418 O=C(NCCSc1ccccc1)C2CCCN2S(=O)(=O)c3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N21 compound treatment 1.34968945E8 -1.99E7 -0.25 2.21296055E8 4.97E7 0.85 0.4256 0.4797 1438435 TimTec1_002419 CC(C)(C)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc3nccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N22 compound treatment 1.15762662E8 -3.91E7 -0.49 1.50267411E8 -2.13E7 -0.36 -0.6045 -0.9893 3083251 TimTec1_002420 Cc1nn(Cc2ccc(o2)C(=O)n3cc(Cl)cn3)c(C)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N23 mock treatment 1.60519292E8 5670000.0 0.07 1.46713715E8 -2.48E7 -0.43 -0.2505 -0.5809 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 N24 mock treatment 1.64156861E8 9300000.0 0.12 2.21699136E8 5.01E7 0.86 0.6894 0.7959 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O01 compound treatment 1.49398783E8 -5460000.0 -0.07 1.68316207E8 -3250000.0 -0.06 -0.0877 -0.9947 3210541 TimTec1_002421 COC(=O)c1cccc(NC(=S)N)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O02 compound treatment 1.4777521E8 -7080000.0 -0.09 1.77904201E8 6340000.0 0.11 0.014 0.0995 3210542 TimTec1_002422 CCC(C)OC(=O)C1CC=CCC1C(=O)Nc2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O03 compound treatment 1.50705125E8 -4150000.0 -0.05 1.78043778E8 6480000.0 0.11 0.0416 0.3398 1368916 TimTec1_002423 CC(C)(C)S(=O)(=O)c1ccc(s1)S(=O)(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O04 compound treatment 1.66809345E8 1.2E7 0.15 1.80257588E8 8690000.0 0.15 0.2113 1.0 3083253 TimTec1_002424 Oc1ccccc1c2cc(nc(n2)c3ccccc3)c4ccccc4O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O05 compound treatment 1.05144661E8 -4.97E7 -0.62 1.70695578E8 -868000.0 -0.01 -0.4514 -0.7237 3210543 TimTec1_002425 Oc1ccc(/C=C/2\N=C(N(C2=O)c3nc4cc(Cl)c(F)cc4s3)c5ccccc5)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O06 compound treatment 1.54326628E8 -527000.0 -0.01 1.88486607E8 1.69E7 0.29 0.2002 0.6908 1018518 TimTec1_002426 NC(=O)Nc1ccc(cc1)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O07 compound treatment 1.78849289E8 2.4E7 0.3 1.89924222E8 1.84E7 0.31 0.4351 0.9998 3210544 TimTec1_002427 Cc1ccc2nc([nH]c2c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O08 compound treatment 1.63687206E8 8830000.0 0.11 2.19572954E8 4.8E7 0.82 0.6595 0.7952 3210545 TimTec1_002428 Cc1ccc(cc1/N=C/c2cc(Br)ccc2O)c3nc4ccccc4[nH]3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O09 compound treatment 1.47696807E8 -7160000.0 -0.09 1.82789808E8 1.12E7 0.19 0.0724 0.3413 1303670 TimTec1_002429 OCCSc1nc2ccccc2n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O10 compound treatment 1.51837747E8 -3020000.0 -0.04 2.09329767E8 3.78E7 0.65 0.4304 0.6646 1421938 TimTec1_002430 O=S(=O)(N1CCC(Cc2ccccc2)CC1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O11 compound treatment 1.37562351E8 -1.73E7 -0.22 1.83119442E8 1.16E7 0.2 -0.0135 -0.046 3083599 TimTec1_002431 CCn1ccc(C(C)C)c1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O12 compound treatment 1.56546654E8 1690000.0 0.02 1.80393496E8 8830000.0 0.15 0.1219 0.7986 1392594 TimTec1_002432 CCOC(=O)c1cnc2ccc(OCC)cc2c1NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O13 compound treatment 1.70639198E8 1.58E7 0.2 1.99769744E8 2.82E7 0.48 0.4814 0.9225 1448583 TimTec1_002433 CC1=NN(C(=O)CSc2nc3ccccc3s2)C(C)(O)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O14 compound treatment 1.55919474E8 1070000.0 0.01 2.14526289E8 4.3E7 0.74 0.5295 0.7198 3210546 TimTec1_002434 COc1ccc(cc1OC)C(=O)NCCOc2cc(C)cc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O15 compound treatment 1.54176965E8 -677000.0 -0.01 2.06451651E8 3.49E7 0.6 0.4163 0.697 1920603 TimTec1_002435 CC1CCN(CC1)C(=O)Nc2ccccc2C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O16 compound treatment 1.18613192E8 -3.62E7 -0.45 1.86150316E8 1.46E7 0.25 -0.1449 -0.2794 1864261 TimTec1_002436 CCC(=O)Oc1ccc(/C=C/c2ccccc2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O17 compound treatment 1.5789542E8 3040000.0 0.04 2.08103719E8 3.65E7 0.63 0.4693 0.7488 3210547 TimTec1_002437 Brc1ccc(cc1)C(=O)CSC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O18 compound treatment 1.75705838E8 2.09E7 0.26 2.02230476E8 3.07E7 0.52 0.5562 0.9482 1208412 TimTec1_002438 CC(C)C(=O)NC1CCCCCCCCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O19 compound treatment 1.55489329E8 635000.0 0.01 2.22066767E8 5.05E7 0.86 0.6169 0.7136 1373698 TimTec1_002439 N#Cc1nc(oc1NCc2ccco2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O20 compound treatment 1.40120639E8 -1.47E7 -0.18 2.20710368E8 4.91E7 0.84 0.4642 0.5389 3210548 TimTec1_002440 Clc1ccc(OCCCC(=O)NCC2CCCO2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O21 compound treatment 1.41026765E8 -1.38E7 -0.17 2.14420654E8 4.29E7 0.73 0.3961 0.5254 1545717 TimTec1_002441 O=C(Nc1ccccc1)C2CC=CCC2C(=O)OCC3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O22 compound treatment 1.46035653E8 -8820000.0 -0.11 2.14416996E8 4.29E7 0.73 0.4405 0.5938 3083601 TimTec1_002442 CCC(C)NC(=O)Nc1ccc(C)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O23 mock treatment 1.07728965E8 -4.71E7 -0.59 2.06080274E8 3.45E7 0.59 -2.0E-4 -3.0E-4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 O24 mock treatment 1.5702232E8 2170000.0 0.03 2.27608131E8 5.6E7 0.96 0.6976 0.7269 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P01 compound treatment 1.81611145E8 2.68E7 0.34 2.10347439E8 3.88E7 0.66 0.7068 0.9501 3210549 TimTec1_002443 COc1ccc(CCNC(=O)NC(C)(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P02 compound treatment 1.11959575E8 -4.29E7 -0.54 9.800582E7 -7.36E7 -1.26 -1.2708 -0.9281 3083602 TimTec1_002444 Cc1ccc(cc1)S(=O)(=O)c2no[n+]([O-])c2S(=O)(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P03 compound treatment 1.78457388E8 2.36E7 0.3 2.01535601E8 3.0E7 0.51 0.5722 0.9659 3210664 TimTec1_002445 Clc1ccc(NC(=O)c2ccc(CSC3=NCCS3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P04 compound treatment 2.7597874E7 -1.27E8 -1.6 5.7083462E7 -1.14E8 -1.96 -2.5145 -0.9948 1549117 TimTec1_002446 CN(C1CC(C)(C)N(O)C(C)(C)C1)C(=O)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P05 compound treatment 1.93927465E8 3.91E7 0.49 1.92236837E8 2.07E7 0.35 0.5968 0.9872 3210665 TimTec1_002447 Cc1ccc(/C(=N\O)/N)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P06 compound treatment 1.92444873E8 3.76E7 0.47 2.03766984E8 3.22E7 0.55 0.7232 0.997 1268004 TimTec1_002448 CN(C1CC(C)(C)NC(C)(C)C1)C(=O)c2ccc(cc2)n3cnnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P07 compound treatment 1.90978E8 3.61E7 0.45 1.3007738E8 -4.15E7 -0.71 -0.1817 -0.2157 3083603 TimTec1_002449 NNC(=O)c1nnn(c1CNc2ccccc2)c3nonc3N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P08 compound treatment 1.77923978E8 2.31E7 0.29 1.27012748E8 -4.46E7 -0.76 -0.3346 -0.4102 1521216 TimTec1_002450 CC1(C)CC(CC(C)(C)N1)NC(=O)NC(=O)c2c(F)cccc2F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P09 compound treatment 1.79535235E8 2.47E7 0.31 2.05061747E8 3.35E7 0.57 0.6244 0.9582 1778355 TimTec1_002451 CC(C)(C)C(=O)Nc1c[nH]c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P10 compound treatment 1.67227605E8 1.24E7 0.16 2.15781779E8 4.42E7 0.76 0.645 0.8347 3210666 TimTec1_002452 Cc1cc(C)c(C#N)c(SCC(=O)C(C)(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P11 compound treatment 1.71730424E8 1.69E7 0.21 2.23236695E8 5.17E7 0.88 0.7752 0.8523 1283021 TimTec1_002453 OC(=O)c1ccccc1NC(=O)c2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P12 compound treatment 1.57566461E8 2710000.0 0.03 2.06808646E8 3.52E7 0.6 0.4507 0.7458 3210667 TimTec1_002454 C(=N/c1cccc(\N=C\c2ccco2)n1)\c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P13 compound treatment 1.44498966E8 -1.04E7 -0.13 1.89700792E8 1.81E7 0.31 0.1277 0.3794 3210668 TimTec1_002455 COC(=O)c1cccc(NC(=O)/C=C/c2ccc3OCOc3c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P14 compound treatment 1.69400163E8 1.45E7 0.18 2.26278472E8 5.47E7 0.94 0.7913 0.8293 3083604 TimTec1_002456 Cc1sc2ncnc(Sc3ncnc4sc(C)c(C)c34)c2c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P15 compound treatment 1.47084311E8 -7770000.0 -0.1 2.31611406E8 6.0E7 1.03 0.6579 0.6372 1287584 TimTec1_002457 CCOC(=O)c1ccc(NC(=O)C(Sc2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P16 compound treatment 1.48259057E8 -6600000.0 -0.08 2.42330792E8 7.08E7 1.21 0.7981 0.6573 3083605 TimTec1_002458 COC(=O)c1ccc(Cl)cc1OC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P17 compound treatment 1.4900848E8 -5850000.0 -0.07 2.31372148E8 5.98E7 1.02 0.6721 0.6548 1716804 TimTec1_002459 CC1CC(O)(CC(O)(c2ccccc2)c3ccccc3)C(C)CN1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P18 compound treatment 1.34393486E8 -2.05E7 -0.26 2.10962673E8 3.94E7 0.67 0.2954 0.4094 3083606 TimTec1_002460 Cc1cccc(N2C(=O)/C(=C\3/C(=O)N(CC(=O)O)c4ccccc34)/SC2=S)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P19 compound treatment 1.47153072E8 -7700000.0 -0.1 2.39109973E8 6.75E7 1.16 0.7493 0.6458 3210669 TimTec1_002461 CC1CCc2c(C#N)c(/N=C/C=C/c3ccccc3)sc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P20 compound treatment 1.37705778E8 -1.71E7 -0.22 2.14255905E8 4.27E7 0.73 0.3646 0.4787 1689508 TimTec1_002462 CC(C)(C)c1ccc(CNC(=O)C2CCCN2S(=O)(=O)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P21 compound treatment 1.46828502E8 -8030000.0 -0.1 1.96382166E8 2.48E7 0.42 0.2292 0.525 3083607 TimTec1_002463 CC(C)(CNC(=O)c1ccccc1Cl)CNC2=NS(=O)(=O)c3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P22 compound treatment 1.26434092E8 -2.84E7 -0.36 2.05669411E8 3.41E7 0.58 0.1607 0.235 1611856 TimTec1_002464 Cc1ccc(CC(=O)[C@@H]2[C@@H](c3ccoc3)C(C#N)(C#N)[C@H]4C=Cc5ccccc5N24)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P23 mock treatment 1.53328852E8 -1530000.0 -0.02 2.1369977E8 4.21E7 0.72 0.4965 0.6881 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2069 P24 mock treatment 1.11697872E8 -4.32E7 -0.54 2.16381006E8 4.48E7 0.77 0.1597 0.1701 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A01 compound treatment 1.51122928E8 -1.41E7 -0.18 1.68893167E8 1.39E7 0.24 0.0436 0.147 1440335 TimTec1_002465 COc1ccc2N(C(=O)CN3C(=O)CCC3=O)C(C)(C)C=C(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A02 compound treatment 1.65299863E8 98000.0 0.0 1.69433891E8 1.45E7 0.25 0.1759 0.7106 3210671 TimTec1_002466 Oc1ccccc1/C=N/c2ccc(cc2)C(=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A03 compound treatment 1.50761848E8 -1.44E7 -0.18 1.54457607E8 -515000.0 -0.01 -0.1343 -0.7407 1235611 TimTec1_002467 CCSc1nc2ccc(NC(=O)c3ccccc3C(=O)O)cc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A04 compound treatment 1.69378993E8 4180000.0 0.05 1.65839336E8 1.09E7 0.19 0.1686 0.8724 3210672 TimTec1_002468 CC(NC(=O)/C=C/c1cccc2ccccc12)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A05 compound treatment 1.62388296E8 -2810000.0 -0.04 1.77308736E8 2.23E7 0.38 0.2454 0.6391 3210673 TimTec1_002469 C[S+](C)c1c(O)n(CCc2ccc(F)cc2)c(=O)[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A06 compound treatment 1.1120911E8 -5.4E7 -0.68 1.75566579E8 2.06E7 0.35 -0.2297 -0.3008 3083610 TimTec1_002470 COC(=O)COc1c(C)cc(Br)cc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A07 compound treatment 1.93468472E8 2.83E7 0.35 1.88190443E8 3.32E7 0.57 0.6528 0.9742 3210674 TimTec1_002471 Oc1cc(=O)n(n2c(=O)cc(O)n(c3ccccc3)c2=S)c(=S)n1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A08 compound treatment 1.73950545E8 8750000.0 0.11 1.97498317E8 4.25E7 0.73 0.5923 0.8046 1664815 TimTec1_002472 Cn1c(Cl)c(CN)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A09 compound treatment 1.74156977E8 8960000.0 0.11 1.7989054E8 2.49E7 0.43 0.381 0.8639 3083613 TimTec1_002473 CCOC(=O)c1cc(C(=O)c2ccc(Cl)cc2)n3c1ccc4ccccc43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A10 compound treatment 1.76046306E8 1.08E7 0.14 1.73458882E8 1.85E7 0.32 0.32 0.9289 3210675 TimTec1_002474 COc1ccc2ccccc2c1/C=N/c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A11 compound treatment 2.04675201E8 3.95E7 0.5 1.67979082E8 1.3E7 0.22 0.5076 0.9349 3210676 TimTec1_002475 Cc1ccc(cc1)N2C(=O)NC(=O)/C(=C/NCCC3=CCCCC3)/C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A12 compound treatment 1.72257905E8 7060000.0 0.09 1.78725418E8 2.38E7 0.41 0.3501 0.8413 3083616 TimTec1_002476 CCn1c2ccccc2c3cc(/C=N/c4cccc(C#N)c4)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A13 compound treatment 1.89803098E8 2.46E7 0.31 1.75150989E8 2.02E7 0.35 0.4625 0.9984 1250862 TimTec1_002477 CC(N1C(=O)c2ccccc2C1=O)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A14 compound treatment 1.91350141E8 2.61E7 0.33 1.14049405E8 -4.09E7 -0.7 -0.2634 -0.3405 1382898 TimTec1_002478 NC(=O)c1cccc(c1)N2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A15 compound treatment 1.85583332E8 2.04E7 0.26 1.71440614E8 1.65E7 0.28 0.3801 0.9988 3210677 TimTec1_002479 Cc1ccc(C(=O)c2ccn(n2)C(=O)c3ccc(F)cc3)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A16 compound treatment 1.91779966E8 2.66E7 0.33 1.76413333E8 2.14E7 0.37 0.4953 0.9989 3083617 TimTec1_002480 COc1cc(OC)c(/C=N/O)cc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A17 compound treatment 1.19141156E8 -4.61E7 -0.58 1.72713395E8 1.77E7 0.3 -0.1938 -0.297 3210678 TimTec1_002481 Clc1cc(NC(=O)C2CC2)ccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A18 compound treatment 1.84789177E8 1.96E7 0.25 1.64192479E8 9220000.0 0.16 0.2853 0.9771 3210679 TimTec1_002482 Cc1c(Cc2ccccc2)sc(/N=C/c3ccc4ccccc4c3)c1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A19 compound treatment 1.89053152E8 2.39E7 0.3 1.51313336E8 -3660000.0 -0.06 0.1673 0.5472 3083619 TimTec1_002483 CCOc1ccc(/N=C\2/C(=O)Nc3ccc(C)c(Br)c23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A20 compound treatment 1.67701258E8 2500000.0 0.03 1.32454692E8 -2.25E7 -0.39 -0.2504 -0.6475 1596328 TimTec1_002484 Oc1ccc(cc1)C2N(CCN2c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A21 compound treatment 1.84746588E8 1.95E7 0.25 1.64862099E8 9890000.0 0.17 0.2931 0.9836 3210680 TimTec1_002485 CCN(CC)c1ccc(/C=N/c2ccc(Br)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A22 compound treatment 1.96022383E8 3.08E7 0.39 1.71548451E8 1.66E7 0.28 0.474 0.9884 3210681 TimTec1_002486 CCc1c(O)nc(SCC(=O)NC(C)(C)C)n(c2ccc(F)cc2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A23 mock treatment 1.87845243E8 2.26E7 0.28 1.86010182E8 3.1E7 0.53 0.5765 0.957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 A24 mock treatment 1.44925993E8 -2.03E7 -0.25 1.72229039E8 1.73E7 0.3 0.029 0.0744 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B01 compound treatment 1.90896445E8 2.57E7 0.32 1.85800634E8 3.08E7 0.53 0.6011 0.972 3210682 TimTec1_002487 CCc1n[nH]c(=O)n1Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B02 compound treatment 1.33243606E8 -3.2E7 -0.4 1.13505789E8 -4.15E7 -0.71 -0.7854 -0.9634 1134528 TimTec1_002488 Clc1cccc(NC(=O)NCCN2Cc3ccccc3C2=O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B03 compound treatment 1.05636806E8 -5.96E7 -0.75 9.9005939E7 -5.6E7 -0.96 -1.2058 -0.9924 1695505 TimTec1_002489 COC(=O)c1ccccc1NC(=O)c2c(C)nc3ccccn23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B04 compound treatment 1.90712346E8 2.55E7 0.32 1.09780393E8 -4.52E7 -0.77 -0.3207 -0.3831 1061354 TimTec1_002490 OC(=O)CCCN1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B05 compound treatment 1.76426085E8 1.12E7 0.14 1.09656503E8 -4.53E7 -0.78 -0.449 -0.5695 3210683 TimTec1_002491 C/C(=N\n1cnnc1)/c2ccc(cc2)n3cnnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B06 compound treatment 1.27149995E8 -3.81E7 -0.48 1.69059111E8 1.41E7 0.24 -0.167 -0.3123 1660739 TimTec1_002492 Clc1cccc(NC(=O)C2CN(Cc3ccccc3)C(=O)C2)c1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B07 compound treatment 2.02437959E8 3.72E7 0.47 1.09456012E8 -4.55E7 -0.78 -0.2207 -0.2429 1742832 TimTec1_002493 CCOC(=O)N(C)CCc1cc2OCOc2cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B08 compound treatment 1.91665356E8 2.65E7 0.33 1.1897345E8 -3.6E7 -0.62 -0.201 -0.2872 3083672 TimTec1_002494 Cc1ccc2nc(=S)nc(c3ccccc3)n2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B09 compound treatment 1.33895415E8 -3.13E7 -0.39 1.02445362E8 -5.25E7 -0.9 -0.9135 -0.931 3210684 TimTec1_002495 N=C1S/C(=C\2/C(=O)NN(C2=O)c3ccccc3)/SC=C1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B10 compound treatment 1.28257706E8 -3.69E7 -0.46 1.70513657E8 1.55E7 0.27 -0.1396 -0.2612 1574189 TimTec1_002496 COc1ccc(cc1)C(C#N)N2N=C(C)CC2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B11 compound treatment 2.7790733E7 -1.37E8 -1.72 3.4107547E7 -1.21E8 -2.07 -2.6819 -0.9959 3083674 TimTec1_002497 O=C1NN=C(CC(N1)c2ccco2)c3cc4ccccc4oc3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B12 compound treatment 1.19977243E8 -4.52E7 -0.57 1.14468663E8 -4.05E7 -0.69 -0.8914 -0.995 1539134 TimTec1_002498 Sc1nc2cc(ccc2s1)C(=O)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B13 compound treatment 1.44213151E8 -2.1E7 -0.26 1.53970182E8 -1000000.0 -0.02 -0.1983 -0.7516 3083676 TimTec1_002499 OCc1cn(nn1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B14 compound treatment 1.74413803E8 9210000.0 0.12 1.51654752E8 -3320000.0 -0.06 0.0415 0.3227 1459359 TimTec1_002500 Clc1ccc(CCN2CC(CC2=O)C(=O)OCC(=O)c3ccc(Cl)cc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B15 compound treatment 1.36525623E8 -2.87E7 -0.36 1.03691499E8 -5.13E7 -0.88 -0.8751 -0.9224 1402941 TimTec1_002501 CN(C)Cc1nnnn1CCn2nnnc2CN(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B16 compound treatment 1.77255638E8 1.21E7 0.15 1.03043793E8 -5.19E7 -0.89 -0.5216 -0.5785 3210801 TimTec1_002502 Cc1ccc(C(=O)COC(=O)c2ccc(cc2)n3cnnn3)c(C)c1.Cc1ccc(C)c(c1)C(=O)COC(=O)c2ccc(cc2)n3cnnn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B17 compound treatment 1.54021948E8 -1.12E7 -0.14 2.27142299E8 7.22E7 1.24 0.7744 0.6228 3083678 TimTec1_002503 COC(=O)c1c(C)c(C)[nH]c(=O)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B18 compound treatment 1.14986757E8 -5.02E7 -0.63 1.7444898E8 1.95E7 0.33 -0.2097 -0.2942 1544714 TimTec1_002504 CCOc1ccc(c2ccccc12)S(=O)(=O)NCC3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B19 compound treatment 1.93578647E8 2.84E7 0.36 1.61198044E8 6220000.0 0.11 0.3271 0.8802 1721791 TimTec1_002505 CC(C)C(C)(NC(=O)c1cccnc1Oc2ccc(Cl)cc2)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B20 compound treatment 1.90830325E8 2.56E7 0.32 1.15673823E8 -3.93E7 -0.67 -0.2484 -0.3331 1358324 TimTec1_002506 CCOC(=O)CN(C)c1nc(cs1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B21 compound treatment 1.90445146E8 2.52E7 0.32 1.02495704E8 -5.25E7 -0.9 -0.4113 -0.4318 1160634 TimTec1_002507 O=C(NCc1nc(cs1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B22 compound treatment 1.36560752E8 -2.86E7 -0.36 1.15331305E8 -3.96E7 -0.68 -0.7339 -0.9558 1033354 TimTec1_002508 O=C(Nc1cccc(c1)C2=NCCN2)Nc3cccc(c3)C4=NCCN4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B23 mock treatment 1.29204684E8 -3.6E7 -0.45 1.17728255E8 -3.72E7 -0.64 -0.7701 -0.9857 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 B24 mock treatment 1.21790664E8 -4.34E7 -0.54 1.31497756E8 -2.35E7 -0.4 -0.6692 -0.9888 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C01 compound treatment 1.59310956E8 -5890000.0 -0.07 1.75294235E8 2.03E7 0.35 0.1937 0.5447 1317591 TimTec1_002509 Brc1ccccc1OCc2ccc(o2)C(=O)Nc3ccc(I)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C02 compound treatment 1.9736817E8 3.22E7 0.4 1.3174709E8 -2.32E7 -0.4 0.0042 0.0074 3210802 TimTec1_002510 Oc1ccc(Br)cc1/C=N/CCC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C03 compound treatment 1.91456367E8 2.63E7 0.33 1.64716364E8 9740000.0 0.17 0.3508 0.9503 3083683 TimTec1_002511 COC(=O)c1ccc(cc1)n2nnnc2SCC(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C04 compound treatment 1.88693308E8 2.35E7 0.29 2.06868718E8 5.19E7 0.89 0.8365 0.8938 3210803 TimTec1_002512 O=C(Nc1nccs1)/C=C/c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C05 compound treatment 1.89597387E8 2.44E7 0.31 1.9230453E8 3.73E7 0.64 0.6683 0.9432 1542712 TimTec1_002513 CCOc1ccc(NC(=O)CSc2nnnn2CC(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C06 compound treatment 1.72400558E8 7200000.0 0.09 2.20374623E8 6.54E7 1.12 0.8555 0.7617 3083686 TimTec1_002514 COc1cc(/C=N/O)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C07 compound treatment 1.5854243E8 -6660000.0 -0.08 1.90153843E8 3.52E7 0.6 0.3668 0.6032 1452827 TimTec1_002515 O=C(CSc1nc2scc(c3cccs3)c2c(=O)n1c4ccccc4)NCc5ccco5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C08 compound treatment 1.81821042E8 1.66E7 0.21 2.12961205E8 5.8E7 0.99 0.8493 0.8373 1593834 TimTec1_002516 OCc1ccccc1CN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C09 compound treatment 1.74798259E8 9600000.0 0.12 1.90799032E8 3.58E7 0.61 0.5188 0.8301 1361213 TimTec1_002517 COC(=O)c1cc(c(C)o1)c2cncnc2c3ccc(OC)c(C)c3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C10 compound treatment 1.86491609E8 2.13E7 0.27 1.79948071E8 2.5E7 0.43 0.4911 0.9743 3210804 TimTec1_002518 COc1ccc2ccccc2c1/C=N/c3cccc(CO)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C11 compound treatment 1.75742095E8 1.05E7 0.13 1.81805288E8 2.68E7 0.46 0.4183 0.8751 1240365 TimTec1_002519 Clc1ccc(cc1)C(=O)Nc2ccccc2C(=O)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C12 compound treatment 1.95502283E8 3.03E7 0.38 1.77418156E8 2.24E7 0.38 0.5405 1.0 3083730 TimTec1_002520 Cc1cc(C)cc(/N=C/c2ccc(C#N)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C13 compound treatment 1.86350805E8 2.11E7 0.27 1.65401311E8 1.04E7 0.18 0.3138 0.9814 3083732 TimTec1_002521 N/C(=C\C(=O)c1ccc(Br)cc1)/C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C14 compound treatment 1.95126378E8 2.99E7 0.38 1.72276268E8 1.73E7 0.3 0.4749 0.9931 3210805 TimTec1_002522 COc1cc(/C=N/c2cc(C)ccc2C)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C15 compound treatment 2.05351736E8 4.01E7 0.5 1.80582312E8 2.56E7 0.44 0.6661 0.9976 3210806 TimTec1_002523 CN1CCN(CC1)C(=O)c2ccccc2NC(=O)c3ccc(F)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C16 compound treatment 1.93961472E8 2.88E7 0.36 1.56702112E8 1730000.0 0.03 0.276 0.7626 1638681 TimTec1_002524 Ic1ccc(NC(=O)c2ccccc2C(=O)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C17 compound treatment 1.66806096E8 1600000.0 0.02 1.48826372E8 -6150000.0 -0.11 -0.0602 -0.5617 3083735 TimTec1_002525 Cc1ccsc1/C=N/c2c(C)cc(C)cc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C18 compound treatment 1.89065228E8 2.39E7 0.3 1.61138524E8 6170000.0 0.11 0.2863 0.902 3210807 TimTec1_002526 CC(=O)N/C(=C/c1ccccc1)/C(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C19 compound treatment 1.88637951E8 2.34E7 0.29 1.45684215E8 -9290000.0 -0.16 0.0955 0.2856 3210808 TimTec1_002527 CCn1c2ccccc2c3cc(/C=N/c4ccc(OC)cc4)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C20 compound treatment 2.06916631E8 4.17E7 0.52 1.57136351E8 2160000.0 0.04 0.3962 0.7553 3083737 TimTec1_002528 COc1cc(NC(=O)c2cccc(Br)c2)nc(OC)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C21 compound treatment 1.92351754E8 2.71E7 0.34 1.47158101E8 -7810000.0 -0.13 0.1462 0.3996 3210809 TimTec1_002529 COc1cc(/C=N/c2ccc(Br)c(Cl)c2)ccc1O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C22 compound treatment 1.85571358E8 2.04E7 0.26 1.4712723E8 -7850000.0 -0.13 0.0857 0.2969 3083739 TimTec1_002530 CC1=C(CNC(=S)N1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C23 mock treatment 1.86743821E8 2.15E7 0.27 1.72311515E8 1.73E7 0.3 0.401 0.9989 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 C24 mock treatment 1.80871088E8 1.57E7 0.2 1.70466813E8 1.55E7 0.27 0.3265 0.9891 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D01 compound treatment 1.89581604E8 2.44E7 0.31 8.3517257E7 -7.15E7 -1.22 -0.6487 -0.5145 3210810 TimTec1_002531 CCCc1nncn1NC(=O)OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D02 compound treatment 1.91761493E8 2.66E7 0.33 9.3666862E7 -6.13E7 -1.05 -0.5065 -0.46 1545647 TimTec1_002532 CCC1=NCC(=O)Nc2ccc(Cl)cc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D03 compound treatment 1.73571008E8 8370000.0 0.1 9.5941687E7 -5.9E7 -1.01 -0.6403 -0.6302 3210811 TimTec1_002533 O=C/1Nc2ccccc2\C1=N\N3C(=O)CC(=O)CC3=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D04 compound treatment 1.57695476E8 -7510000.0 -0.09 9.0779313E7 -6.42E7 -1.1 -0.8436 -0.7649 1629795 TimTec1_002534 O=C(COc1ccccc1C#N)Nc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D05 compound treatment 2.11423595E8 4.62E7 0.58 8.8255421E7 -6.67E7 -1.14 -0.3976 -0.3104 1595606 TimTec1_002535 Cc1cc(C)n(CNc2c(C)n(C)n(c3ccccc3)c2=O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D06 compound treatment 2.13284785E8 4.81E7 0.6 9.9994812E7 -5.5E7 -0.94 -0.239 -0.2138 1277145 TimTec1_002536 CC1=NN(C(=O)Cc2ccccc2)C(C)(C)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D07 compound treatment 2.48870835E8 8.37E7 1.05 9.3493412E7 -6.15E7 -1.05 -0.002 -0.0013 3210812 TimTec1_002537 CC(=O)OC1=NN(N(=C1)O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D08 compound treatment 1.98054806E8 3.29E7 0.41 8.7825316E7 -6.71E7 -1.15 -0.5214 -0.427 3210813 TimTec1_002538 CCCc1ccc(OCCNC(=O)c2ccc3ccccc3n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D09 compound treatment 1.08862455E8 -5.63E7 -0.71 1.00361133E8 -5.46E7 -0.93 -1.1608 -0.9905 1241793 TimTec1_002539 CCOC(=O)Cn1c2CCC(Cc2sc1=N)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D10 compound treatment 1.99223458E8 3.4E7 0.43 9.0594499E7 -6.44E7 -1.1 -0.4775 -0.404 1587827 TimTec1_002540 OC(=O)CC1(CC(=O)NCc2ccc3OCOc3c2)CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D11 compound treatment 1.84637086E8 1.94E7 0.24 9.2675526E7 -6.23E7 -1.07 -0.5817 -0.5317 3083745 TimTec1_002541 Clc1ccc(CNC(=C(C#N)C#N)Nc2ccccc2)cn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D12 compound treatment 2.20889595E8 5.57E7 0.7 8.9927864E7 -6.5E7 -1.11 -0.2934 -0.2232 1378435 TimTec1_002542 CCCC(O)(CCC)C(=O)NN1CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D13 compound treatment 1.76277384E8 1.11E7 0.14 6.8128521E7 -8.68E7 -1.49 -0.9529 -0.6382 1537190 TimTec1_002543 CCCC(=O)n1c(=O)oc2cc(Br)ccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D14 compound treatment 1.82393462E8 1.72E7 0.22 8.6494874E7 -6.85E7 -1.17 -0.6764 -0.5675 3083789 TimTec1_002544 COc1ccc(C#N)c(c1)S(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D15 compound treatment 1.78170328E8 1.3E7 0.16 8.5054823E7 -6.99E7 -1.2 -0.7313 -0.6054 3241 TimTec1_002545 CN1CCCN=C1/C=C/c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D16 compound treatment 2.17518965E8 5.23E7 0.66 1.60295362E8 5320000.0 0.09 0.5285 0.7976 3083792 TimTec1_002546 CNc1nc(Nc2ccc(OC(F)(F)F)cc2)nc(OCC(F)(F)F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D17 compound treatment 1.73656656E8 8450000.0 0.11 1.4973817E8 -5230000.0 -0.09 0.0116 0.0838 1551509 TimTec1_002547 C(N1CCOCC1)c2ccc(cc2)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D18 compound treatment 1.94546612E8 2.93E7 0.37 8.8977592E7 -6.6E7 -1.13 -0.5385 -0.4532 3210815 TimTec1_002548 CCC1(C)OC(=O)N2CCc3ccccc3C21C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D19 compound treatment 1.87739188E8 2.25E7 0.28 1.75515546E8 2.05E7 0.35 0.4486 0.9941 1026666 TimTec1_002549 Clc1ccccc1NC(=O)Nc2ccccc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D20 compound treatment 1.71908956E8 6710000.0 0.08 1.76956475E8 2.2E7 0.38 0.3256 0.8444 3083794 TimTec1_002550 Oc1cc(n[nH]1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D21 compound treatment 2.11678866E8 4.65E7 0.58 1.83043941E8 2.81E7 0.48 0.752 0.9954 1273445 TimTec1_002551 CC(=O)Nc1cc2OCCOc2cc1C(=O)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D22 compound treatment 2.01806556E8 3.66E7 0.46 1.86924097E8 3.2E7 0.55 0.7114 0.9962 1411171 TimTec1_002552 OCCN1CCN(CC1)S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D23 mock treatment 1.92488367E8 2.73E7 0.34 1.7468888E8 1.97E7 0.34 0.4807 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 D24 mock treatment 1.75832515E8 1.06E7 0.13 1.62367844E8 7390000.0 0.13 0.1838 0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E01 compound treatment 1.83915195E8 1.87E7 0.23 1.62907072E8 7930000.0 0.14 0.262 0.9662 1153857 TimTec1_002553 COc1ccc(NC(=S)N2CCN(C)CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E02 compound treatment 1.75829907E8 1.06E7 0.13 1.48016772E8 -6960000.0 -0.12 0.0101 0.0564 1699449 TimTec1_002554 S=C(Nc1sc2CCCc2c1C#N)Nc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E03 compound treatment 2.11453706E8 4.63E7 0.58 1.78602495E8 2.36E7 0.4 0.6963 0.9844 1502764 TimTec1_002555 Cc1cc(C)n(n1)C(Nc2cc(C)ccn2)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E04 compound treatment 2.31895757E8 6.67E7 0.84 1.95635494E8 4.07E7 0.7 1.0838 0.9958 1627110 TimTec1_002556 OCc1ccccc1CNc2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E05 compound treatment 1.68586481E8 3380000.0 0.04 1.42304962E8 -1.27E7 -0.22 -0.1233 -0.5581 1382760 TimTec1_002557 CCC(=O)Nc1nc(NC(=O)CC)c2ncn(C(=O)CC)c2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E06 compound treatment 2.16983424E8 5.18E7 0.65 1.62438363E8 7470000.0 0.13 0.5497 0.8303 1126108 TimTec1_002558 COc1ccc(CCNc2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E07 compound treatment 1.75377413E8 1.02E7 0.13 1.5229942E8 -2670000.0 -0.05 0.0579 0.427 3083800 TimTec1_002559 COc1ccc(cc1)C2=C3NN=C(N)N3NN2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E08 compound treatment 2.15505579E8 5.03E7 0.63 2.15984621E8 6.1E7 1.04 1.1847 0.9709 1594522 TimTec1_002560 CNCc1cc2ccccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E09 compound treatment 1.64358316E8 -844000.0 -0.01 1.77081255E8 2.21E7 0.38 0.2601 0.6871 3210930 TimTec1_002561 COc1ccc(c(O)c1)c2ncnc(c2c3cscn3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E10 compound treatment 2.27568083E8 6.24E7 0.78 1.3419255E8 -2.08E7 -0.36 0.3017 0.351 3083802 TimTec1_002562 CCOC(=O)c1ccc(/N=C/c2ccc3ccccc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E11 compound treatment 2.32693822E8 6.75E7 0.85 1.20776997E8 -3.42E7 -0.59 0.1848 0.1795 1258628 TimTec1_002563 NS(=O)(=O)c1ccc(CCNC(=O)C(Sc2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E12 compound treatment 1.93945044E8 2.87E7 0.36 1.53630309E8 -1340000.0 -0.02 0.2387 0.6607 3083804 TimTec1_002564 CCN(CC)c1ccc(/C=N/c2cc(C)cc(C)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E13 compound treatment 1.86089271E8 2.09E7 0.26 1.82459895E8 2.75E7 0.47 0.518 0.9618 3210931 TimTec1_002565 Cc1ccc(O)c(c1)c2cc(no2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E14 compound treatment 1.34656653E8 -3.05E7 -0.38 1.39017289E8 -1.6E7 -0.27 -0.4641 -0.9862 1565284 TimTec1_002566 CN(C)c1ccc(cc1)C2N(Cc3ccccc3)CCN2Cc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E15 compound treatment 1.12978715E8 -5.22E7 -0.66 1.84258609E8 2.93E7 0.5 -0.1088 -0.1318 1532411 TimTec1_002567 O=C(Nc1ccccc1)Nc2ccc(cc2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E16 compound treatment 2.26142251E8 6.09E7 0.76 1.94837176E8 3.99E7 0.68 1.0231 0.9984 1209164 TimTec1_002568 N#Cc1ccc(cc1)C2N(CCN2c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E17 compound treatment 1.60431117E8 -4770000.0 -0.06 1.27773679E8 -2.72E7 -0.47 -0.3715 -0.7915 1709264 TimTec1_002569 OC(c1cccs1)c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E18 compound treatment 1.50792393E8 -1.44E7 -0.18 1.27645528E8 -2.73E7 -0.47 -0.4586 -0.9144 3210932 TimTec1_002570 CCn1c2ccccc2c3cc(/C=N/c4ccc(C)cc4O)ccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E19 compound treatment 1.81181349E8 1.6E7 0.2 1.82882593E8 2.79E7 0.48 0.4796 0.9256 3083808 TimTec1_002571 FC(F)(F)Oc1ccc(/N=C/c2ccc[nH]2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E20 compound treatment 2.02311665E8 3.71E7 0.47 2.04461088E8 4.95E7 0.85 0.9282 0.9602 1012470 TimTec1_002572 COc1ccc(CNC2CCCCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E21 compound treatment 1.44499627E8 -2.07E7 -0.26 1.37936693E8 -1.7E7 -0.29 -0.3898 -0.9983 3210933 TimTec1_002573 COC(=O)c1ccc(/N=C/c2ccc(Br)s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E22 compound treatment 1.90081776E8 2.49E7 0.31 1.19993277E8 -3.5E7 -0.6 -0.2027 -0.3002 1473837 TimTec1_002574 O=C(NCc1ccco1)C2CCCN2S(=O)(=O)c3ccc4ccccc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E23 mock treatment 1.92512382E8 2.73E7 0.34 1.58007407E8 3030000.0 0.05 0.279 0.8051 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 E24 mock treatment 1.42920207E8 -2.23E7 -0.28 1.34633271E8 -2.03E7 -0.35 -0.4438 -0.9941 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F01 compound treatment 1.15388117E8 -4.98E7 -0.62 1.12183429E8 -4.28E7 -0.73 -0.9598 -0.9969 1161969 TimTec1_002575 CN(C)c1ccc(cc1)C2ON2[C@H]3CC[C@H](O)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F02 compound treatment 1.35554306E8 -2.96E7 -0.37 1.19787552E8 -3.52E7 -0.6 -0.6889 -0.9732 1195693 TimTec1_002576 COc1ccc(cc1OC)C2OC(=O)C(=C(O)C2(C)C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F03 compound treatment 1.1625722E8 -4.89E7 -0.61 1.25793633E8 -2.92E7 -0.5 -0.7873 -0.9948 3210934 TimTec1_002577 CN(C)c1ccc(/C=C(/NC(=O)c2ccccc2)\C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F04 compound treatment 1.87533392E8 2.23E7 0.28 1.42912755E8 -1.21E7 -0.21 0.0521 0.1497 1326441 TimTec1_002578 Nc1nonc1OCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F05 compound treatment 1.43765771E8 -2.14E7 -0.27 9.8150572E7 -5.68E7 -0.97 -0.8779 -0.87 3210935 TimTec1_002579 Clc1ccc(/C=N/N2C(=O)CNC2=O)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F06 compound treatment 1.26835373E8 -3.84E7 -0.48 1.38464822E8 -1.65E7 -0.28 -0.5401 -0.9678 3083845 TimTec1_002580 CCOC(=O)c1cc(C)[nH]c(=S)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F07 compound treatment 1.97607293E8 3.24E7 0.41 1.96553646E8 4.16E7 0.71 0.7907 0.9647 3210936 TimTec1_002581 CCOC(=O)C1C(C)NC(=O)N=C1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F08 compound treatment 1.42578103E8 -2.26E7 -0.28 1.29621518E8 -2.54E7 -0.43 -0.5075 -0.9788 1507322 TimTec1_002582 COc1ccc(cc1OC)C(=O)CSc2nc(N)cc(=O)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F09 compound treatment 1.36398337E8 -2.88E7 -0.36 1.42115382E8 -1.29E7 -0.22 -0.4111 -0.9717 1564107 TimTec1_002583 Oc1ccccc1SCC(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F10 compound treatment 1.32049707E8 -3.32E7 -0.42 1.58216837E8 3240000.0 0.06 -0.2548 -0.6073 1190430 TimTec1_002584 OC(=O)c1ccccc1c2nnn[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F11 compound treatment 1.59909724E8 -5290000.0 -0.07 1.57894238E8 2920000.0 0.05 -0.0116 -0.1394 3210937 TimTec1_002585 Cc1ccnc(NS(=O)(=O)c2ccc(/N=C/3\SCC(=O)N3CC=C)cc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F12 compound treatment 1.51230972E8 -1.4E7 -0.18 1.56131461E8 1160000.0 0.02 -0.1099 -0.6231 3210938 TimTec1_002586 COC(=O)C1=CN(Cc2ccc(Cl)cc2)C=C(C1c3cccs3)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F13 compound treatment 1.32629439E8 -3.26E7 -0.41 1.31035913E8 -2.39E7 -0.41 -0.5787 -1.0 1386655 TimTec1_002587 COc1ccc(OC)c(c1)C(=O)COc2ccccc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F14 compound treatment 1.28476475E8 -3.67E7 -0.46 1.46014974E8 -8960000.0 -0.15 -0.4342 -0.8942 1502288 TimTec1_002588 Nc1nc(=O)n(CCC#N)cc1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F15 compound treatment 1.2709473E8 -3.81E7 -0.48 1.12993229E8 -4.2E7 -0.72 -0.8462 -0.9804 1508658 TimTec1_002589 CSC1=C(C#N)C2(CCCCC2)C3=C(CCC3)N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F16 compound treatment 1.36555474E8 -2.86E7 -0.36 1.83676347E8 2.87E7 0.49 0.0933 0.1533 1232692 TimTec1_002590 Cc1cccc(C)c1NC(=O)C(NC(=O)c2ccc(cc2)n3cnnn3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F17 compound treatment 2.14172955E8 4.9E7 0.61 1.50571488E8 -4400000.0 -0.08 0.3811 0.6158 3083851 TimTec1_002591 COc1ccc(Cl)cc1C(=O)NN2C(=CC(C)(C)NC2=S)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F18 compound treatment 1.3025256E8 -3.49E7 -0.44 1.45729822E8 -9240000.0 -0.16 -0.4219 -0.9052 3210939 TimTec1_002592 FC(F)(F)C1(N=C(OC(=N1)N2CCOCC2)N3CCOCC3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F19 compound treatment 1.44299451E8 -2.09E7 -0.26 2.03867897E8 4.89E7 0.84 0.4064 0.4634 3083853 TimTec1_002593 NC1=NC(=O)C(CC(=O)O)CS1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F20 compound treatment 1.92780617E8 2.76E7 0.35 1.89822786E8 3.48E7 0.6 0.6665 0.9664 1554458 TimTec1_002594 CCOC(=O)C1(CCN(CCC(=O)Nc2ccc(cc2)C(=O)OC)CC1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F21 compound treatment 1.32419281E8 -3.28E7 -0.41 2.26821266E8 7.18E7 1.23 0.5789 0.4464 1231612 TimTec1_002595 COc1ccc(cc1)C2C(C)C3(O)CC(C#N)(C(=O)N3)C2(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F22 compound treatment 1.86309023E8 2.11E7 0.26 1.84043257E8 2.91E7 0.5 0.5391 0.9564 1368021 TimTec1_002596 CC(=O)N(CCOc1ccccc1)CCOc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F23 mock treatment 1.27324181E8 -3.79E7 -0.48 2.12644233E8 5.77E7 0.99 0.3621 0.3305 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 F24 mock treatment 1.76287045E8 1.11E7 0.14 1.27587633E8 -2.74E7 -0.47 -0.2332 -0.4768 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G01 compound treatment 1.08752043E8 -5.64E7 -0.71 1.45517143E8 -9460000.0 -0.16 -0.6152 -0.8469 1248844 TimTec1_002597 Cc1ccc(o1)C(=O)NCC2CCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G02 compound treatment 1.66903218E8 1700000.0 0.02 1.50933748E8 -4040000.0 -0.07 -0.0338 -0.4671 3210940 TimTec1_002598 S=C(Nc1ccccc1)Nc2cccc(C#N)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G03 compound treatment 1.71710433E8 6510000.0 0.08 1.33982099E8 -2.1E7 -0.36 -0.1963 -0.5329 1385961 TimTec1_002599 Cc1ccc(cc1C)C(=O)COC(=O)c2ccc(cc2)c3nnc(o3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G04 compound treatment 1.26160003E8 -3.9E7 -0.49 1.46281074E8 -8690000.0 -0.15 -0.4515 -0.8821 1301988 TimTec1_002600 Brc1c(OCC(=O)NCc2ccccc2)ccc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G05 compound treatment 1.18159374E8 -4.7E7 -0.59 1.54688876E8 -284000.0 0.0 -0.4207 -0.7129 3210941 TimTec1_002601 O=C1CNC(=O)N1/N=C/2\C(=O)Nc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G06 compound treatment 1.10687364E8 -5.45E7 -0.68 1.54299638E8 -673000.0 -0.01 -0.4917 -0.7189 3083899 TimTec1_002602 COc1ccc(CCNCc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G07 compound treatment 1.4693619E8 -1.83E7 -0.23 1.32891315E8 -2.21E7 -0.38 -0.4293 -0.9712 3083901 TimTec1_002603 Cc1c(C#N)c(=O)n(nc1C(=O)O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G08 compound treatment 1.57092366E8 -8110000.0 -0.1 1.06809793E8 -4.82E7 -0.82 -0.6549 -0.7884 3210942 TimTec1_002604 Cn1ccnc1C(O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G09 compound treatment 1.43386839E8 -2.18E7 -0.27 1.02216194E8 -5.28E7 -0.9 -0.8321 -0.8818 3210943 TimTec1_002605 CCCN1C(=O)/C(=C\2/C(=O)N(CC=C)c3ccccc23)/SC1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G10 compound treatment 1.17004333E8 -4.82E7 -0.6 1.07427134E8 -4.75E7 -0.81 -1.003 -0.9893 3083904 TimTec1_002606 NC(=O)c1cccc(/N=C/c2ccc3ccccc3c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G11 compound treatment 1.21363203E8 -4.38E7 -0.55 1.25585702E8 -2.94E7 -0.5 -0.7446 -0.999 3210944 TimTec1_002607 CCOc1ccccc1/C=N/c2ccc(cc2)S(=O)(=O)N3CCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G12 compound treatment 1.33068853E8 -3.21E7 -0.4 1.79811398E8 2.48E7 0.43 0.0156 0.0267 3083906 TimTec1_002608 Cc1ccc(C)c(/N=C/c2ccc(C#N)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G13 compound treatment 1.20385017E8 -4.48E7 -0.56 1.60135196E8 5160000.0 0.09 -0.3351 -0.5887 3210945 TimTec1_002609 Oc1ccccc1c2cc(n(n2)c3ccccc3)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G14 compound treatment 1.5364257E8 -1.16E7 -0.15 1.1040792E8 -4.46E7 -0.76 -0.642 -0.8267 3083907 TimTec1_002610 Oc1c(Cl)cc(Cl)cc1/C=N/c2sc3CCCc3c2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G15 compound treatment 1.10084693E8 -5.51E7 -0.69 1.16071811E8 -3.89E7 -0.67 -0.9598 -0.9998 1229191 TimTec1_002611 Nc1ccc(cc1)C(=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G16 compound treatment 1.14733928E8 -5.05E7 -0.63 1.41725346E8 -1.32E7 -0.23 -0.608 -0.9041 1298485 TimTec1_002612 C=CCC(CC=C)(NC(=O)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G17 compound treatment 1.86893167E8 2.17E7 0.27 1.43027178E8 -1.19E7 -0.2 0.0478 0.1405 3210946 TimTec1_002613 CSc1ccc(/C=N/c2ccc(Nc3ccccc3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G18 compound treatment 1.45286041E8 -1.99E7 -0.25 1.07325099E8 -4.76E7 -0.82 -0.7534 -0.8832 3210947 TimTec1_002614 Cc1[nH]c2ccccc2c1/C=N/c3ccc(Cl)cc3C(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G19 compound treatment 1.19044842E8 -4.62E7 -0.58 9.3573759E7 -6.14E7 -1.05 -1.1526 -0.9605 3083909 TimTec1_002615 COC(=O)CSc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G20 compound treatment 1.47630676E8 -1.76E7 -0.22 1.18325339E8 -3.66E7 -0.63 -0.5995 -0.9015 1173404 TimTec1_002616 COc1ccc2ccccc2c1C(O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G21 compound treatment 1.23220906E8 -4.2E7 -0.53 1.26006133E8 -2.9E7 -0.5 -0.723 -0.9995 3083910 TimTec1_002617 CCN(CC)c1ccc(/N=C/c2cccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G22 compound treatment 1.47772363E8 -1.74E7 -0.22 1.1125449E8 -4.37E7 -0.75 -0.6838 -0.877 3210948 TimTec1_002618 CN1C(=O)/C(=C\c2c(O)c3ccccc3n(C)c2=O)/C(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G23 mock treatment 1.20530432E8 -4.47E7 -0.56 1.12835519E8 -4.21E7 -0.72 -0.9063 -0.9922 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 G24 mock treatment 1.74195935E8 8990000.0 0.11 1.22548061E8 -3.24E7 -0.56 -0.3127 -0.5521 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H01 compound treatment 1.08227316E8 -5.7E7 -0.71 1.28636425E8 -2.63E7 -0.45 -0.8242 -0.9753 1619414 TimTec1_002619 Cc1cc(no1)c2c(O)c3ccccc3n(C)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H02 compound treatment 1.17378987E8 -4.78E7 -0.6 1.94186673E8 3.92E7 0.67 0.0504 0.056 1650607 TimTec1_002620 CC1C(OC(=O)C2(CCCCC2)C1=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H03 compound treatment 1.09957737E8 -5.52E7 -0.69 1.42248752E8 -1.27E7 -0.22 -0.6441 -0.8866 1490854 TimTec1_002621 O=COCC1OC(OC=O)C(Nc2ccccc2)C(OC=O)C1OC=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H04 compound treatment 1.87119474E8 2.19E7 0.27 1.15130307E8 -3.98E7 -0.68 -0.2878 -0.3914 1609235 TimTec1_002622 Fc1ccc(CSc2nc3cccnc3[nH]2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H05 compound treatment 1.28331375E8 -3.69E7 -0.46 1.28679961E8 -2.63E7 -0.45 -0.6453 -0.9999 3211069 TimTec1_002623 C/C(=N\N1C(=O)CC(=O)NC1=S)/c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H06 compound treatment 1.465673E8 -1.86E7 -0.23 1.12220283E8 -4.28E7 -0.73 -0.6828 -0.8887 3083914 TimTec1_002624 CC1SC(NC1=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H07 compound treatment 1.80037359E8 1.48E7 0.19 1.11211478E8 -4.38E7 -0.75 -0.3981 -0.5158 1308303 TimTec1_002625 CCOC(=O)c1cccc(c1)C(=O)NC2=CC(=O)CC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H08 compound treatment 1.09362667E8 -5.58E7 -0.7 1.25426884E8 -2.95E7 -0.51 -0.8529 -0.9872 3083916 TimTec1_002626 COc1ccc(cc1)C(=O)c2nocc2C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H09 compound treatment 1.37532156E8 -2.77E7 -0.35 1.03361835E8 -5.16E7 -0.88 -0.8702 -0.9167 1428534 TimTec1_002627 O=c1oc2ccccc2cc1C3=NC(=S)NC(C3)c4ccc5OCOc5c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H10 compound treatment 1.03380245E8 -6.18E7 -0.78 1.20821124E8 -3.42E7 -0.58 -0.9618 -0.9903 1170391 TimTec1_002628 NC(=O)CN1C(=O)c2cccc3cccc1c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H11 compound treatment 8.9570245E7 -7.56E7 -0.95 1.0139612E8 -5.36E7 -0.92 -1.3194 -0.9999 3211070 TimTec1_002629 S=c1nc(/N=C/c2ccco2)cc(/N=C/c3ccco3)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H12 compound treatment 1.06734565E8 -5.85E7 -0.73 1.41253496E8 -1.37E7 -0.23 -0.6847 -0.8891 1704493 TimTec1_002630 Cc1cc2OC(=C(C#N)C3(C(=O)N(CC(=O)O)c4ccccc43)c2c(=O)o1)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H13 compound treatment 9.6761915E7 -6.84E7 -0.86 1.09762512E8 -4.52E7 -0.77 -1.1543 -0.9987 1554929 TimTec1_002631 O=C(Oc1cccnc1)c2cc3ccccc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H14 compound treatment 1.10407329E8 -5.48E7 -0.69 1.5717821E8 2210000.0 0.04 -0.4594 -0.6673 1212825 TimTec1_002632 Cc1[nH]c2ccccc2c1CCN3C(=O)CCC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H15 compound treatment 1.13568854E8 -5.16E7 -0.65 1.78733778E8 2.38E7 0.41 -0.1704 -0.2228 1243289 TimTec1_002633 COC(=O)C1=C(C)N(C(=O)C1)c2ccc(cc2)C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H16 compound treatment 1.49681874E8 -1.55E7 -0.19 1.37868246E8 -1.71E7 -0.29 -0.3447 -0.9803 1495691 TimTec1_002634 CC(O)(C#CCN1CCCCC1)C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H17 compound treatment 1.81766792E8 1.66E7 0.21 1.15645816E8 -3.93E7 -0.67 -0.3291 -0.4671 1405861 TimTec1_002635 CCN(CC)C(=O)CSc1nc2CCCCc2cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H18 compound treatment 8.9518206E7 -7.57E7 -0.95 8.2680628E7 -7.23E7 -1.24 -1.5464 -0.9914 3083985 TimTec1_002636 CCc1c(C)nc(N)nc1S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H19 compound treatment 1.05286576E8 -5.99E7 -0.75 1.20838974E8 -3.41E7 -0.58 -0.9446 -0.9922 1285150 TimTec1_002637 CC1(O)NC(=O)C2(C#N)C(C#N)(C#N)C21c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H20 compound treatment 1.53042629E8 -1.22E7 -0.15 1.285246E8 -2.64E7 -0.45 -0.428 -0.8959 1677097 TimTec1_002638 Cc1nc(C(=O)N)c(N)n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H21 compound treatment 1.71712606E8 6510000.0 0.08 1.18147329E8 -3.68E7 -0.63 -0.388 -0.6104 1163471 TimTec1_002639 COC(=O)c1ccc(NC(=O)CSc2nccn2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H22 compound treatment 1.08068381E8 -5.71E7 -0.72 1.13693692E8 -4.13E7 -0.71 -1.0064 -1.0 3083989 TimTec1_002640 Cc1cc(C)n(CNc2nccs2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H23 mock treatment 1.24927785E8 -4.03E7 -0.51 1.74543297E8 1.96E7 0.34 -0.1204 -0.1986 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 H24 mock treatment 1.80176379E8 1.5E7 0.19 1.15337915E8 -3.96E7 -0.68 -0.3469 -0.4928 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I01 compound treatment 1.96414297E8 3.12E7 0.39 1.85336861E8 3.04E7 0.52 0.6444 0.9902 1611631 TimTec1_002641 O=C(Nc1ccccc1)Nc2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I02 compound treatment 2.08098486E8 4.29E7 0.54 1.73072802E8 1.81E7 0.31 0.5996 0.9656 1685279 TimTec1_002642 COc1ccc(cc1I)C(=O)Nc2ccc(Oc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I03 compound treatment 1.93912956E8 2.87E7 0.36 1.81444041E8 2.65E7 0.45 0.5751 0.9935 1725903 TimTec1_002643 CCOC(=O)C(C)Oc1ccc2oc(=O)cc(C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I04 compound treatment 2.05030444E8 3.98E7 0.5 1.94840096E8 3.99E7 0.68 0.8359 0.9883 1725678 TimTec1_002644 Cc1ccc(NC(=O)COc2ccc3ccccc3c2Br)cc1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I05 compound treatment 1.8823582E8 2.3E7 0.29 1.666589E8 1.17E7 0.2 0.3458 0.9839 3083992 TimTec1_002645 CN(C)c1ccc(/C=N/N2C(=O)CNC2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I06 compound treatment 1.74413889E8 9210000.0 0.12 1.73798778E8 1.88E7 0.32 0.3096 0.9043 3211071 TimTec1_002646 CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1OC(=O)C(O)C(O)C(=O)O[C@H]2C[C@H](C)CC[C@H]2C(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I07 compound treatment 2.11893622E8 4.67E7 0.59 1.95010505E8 4.0E7 0.69 0.8988 0.9969 1159008 TimTec1_002647 O=C(CSc1ncnc2[nH]cnc12)NCCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I08 compound treatment 1.85957585E8 2.08E7 0.26 1.72565881E8 1.76E7 0.3 0.3971 0.9974 3211072 TimTec1_002648 Cc1ccc(/N=C/c2ccc(Br)s2)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I09 compound treatment 1.86498162E8 2.13E7 0.27 1.77381031E8 2.24E7 0.38 0.4601 0.9844 1275751 TimTec1_002649 Cc1cccc(c1)N(CC(=O)Nc2ccc3c(c2)oc4ccccc43)S(=O)(=O)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I10 compound treatment 2.15677808E8 5.05E7 0.63 1.73246819E8 1.83E7 0.31 0.6689 0.9472 3083996 TimTec1_002650 COc1ccc(/N=C/c2ccc3ccccc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I11 compound treatment 1.65014414E8 -187000.0 0.0 1.56896917E8 1920000.0 0.03 0.0216 0.6549 3211073 TimTec1_002651 CC(=O)Nc1ccc(cc1)c2csc(Nc3ccccc3C)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I12 compound treatment 1.78233855E8 1.3E7 0.16 1.628201E8 7850000.0 0.13 0.2106 0.9952 3083998 TimTec1_002652 Cc1cccc(/C=N/c2cccc(O)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I13 compound treatment 2.02685238E8 3.75E7 0.47 1.77412977E8 2.24E7 0.38 0.6041 0.995 3083999 TimTec1_002653 O=c1n(OCc2ccccc2)c(SCc3ccccc3)nc4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I14 compound treatment 2.07549549E8 4.23E7 0.53 1.63120961E8 8150000.0 0.14 0.4743 0.8635 3211074 TimTec1_002654 Cc1ccc(/C=N/c2ccc(Oc3ccccc3)cc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I15 compound treatment 1.92519602E8 2.73E7 0.34 1.71462574E8 1.65E7 0.28 0.4419 0.9954 3211075 TimTec1_002655 O=C(Nc1ccccc1)Nc2ccc(cc2)C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I16 compound treatment 2.14299249E8 4.91E7 0.62 1.75806581E8 2.08E7 0.36 0.6877 0.9663 1270363 TimTec1_002656 Cc1ccc(cc1)S(=O)(=O)NC(CC=C)(CC=C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I17 compound treatment 2.19319499E8 5.41E7 0.68 1.88582044E8 3.36E7 0.58 0.8869 0.9966 3211076 TimTec1_002657 N#Cc1ccc(/C=N/c2cccc3c(\N=C\c4ccc(C#N)cc4)cccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I18 compound treatment 2.2513594E8 5.99E7 0.75 1.72366133E8 1.74E7 0.3 0.7422 0.9178 3084003 TimTec1_002658 NC(=O)c1ccccc1/N=C/c2ccc(O)c(O)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I19 compound treatment 1.95788994E8 3.06E7 0.38 1.65847368E8 1.09E7 0.19 0.4029 0.9448 3211077 TimTec1_002659 Oc1ccc(Br)cc1/C=N/Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I20 compound treatment 2.00006714E8 3.48E7 0.44 1.44949626E8 -1.0E7 -0.17 0.1874 0.3995 1542526 TimTec1_002660 COc1cc(CNc2ccccc2)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I21 compound treatment 2.08585383E8 4.34E7 0.54 1.82560585E8 2.76E7 0.47 0.7188 0.9975 3211078 TimTec1_002661 N#Cc1cccc(/N=C/c2ccc3OCOc3c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I22 compound treatment 1.81444089E8 1.62E7 0.2 1.65384804E8 1.04E7 0.18 0.2701 0.9978 1646643 TimTec1_002662 CCn1c(=O)c(C(C)Nc2ccco2)c(O)c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I23 mock treatment 1.87680269E8 2.25E7 0.28 1.65594294E8 1.06E7 0.18 0.328 0.9775 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 I24 mock treatment 1.67678738E8 2480000.0 0.03 1.86991177E8 3.2E7 0.55 0.4095 0.746 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J01 compound treatment 1.72354023E8 7150000.0 0.09 1.64347905E8 9370000.0 0.16 0.1769 0.9623 1132674 TimTec1_002663 CCC1=CC(=NC(C)CN1)c2c(O)c3ccccc3n(C)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J02 compound treatment 1.60196857E8 -5010000.0 -0.06 1.641625E8 9190000.0 0.16 0.0668 0.3946 3084072 TimTec1_002664 OC(=O)c1ccc2nsnc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J03 compound treatment 1.98083852E8 3.29E7 0.41 1.76971316E8 2.2E7 0.38 0.5579 0.999 1532331 TimTec1_002665 Fc1ccc(cc1)N2C(=S)N=C(CC23C(=O)Nc4ccccc43)c5ccc(F)cc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J04 compound treatment 1.82729507E8 1.75E7 0.22 1.7457836E8 1.96E7 0.34 0.3928 0.979 3084075 TimTec1_002666 FC(F)(F)c1ccc2n(Cc3ccccc3)c(=O)c(=O)[nH]c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J05 compound treatment 1.87257722E8 2.21E7 0.28 1.27676353E8 -2.73E7 -0.47 -0.1348 -0.2482 1654151 TimTec1_002667 O=c1ccn(CN2CCCCC2)c(=O)n1CN3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J06 compound treatment 1.93508955E8 2.83E7 0.36 1.35138297E8 -1.98E7 -0.34 0.011 0.0224 1571522 TimTec1_002668 CN1NC2(CCCCC2)N(C1=S)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J07 compound treatment 1.94153711E8 2.9E7 0.36 1.86767979E8 3.18E7 0.54 0.6417 0.9807 3211079 TimTec1_002669 Oc1ccccc1/C=N/c2cc(ccc2O)S(=O)(=O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J08 compound treatment 1.88466637E8 2.33E7 0.29 1.66585019E8 1.16E7 0.2 0.3469 0.9825 1488051 TimTec1_002670 CC1CN(CCc2ccccc2)CCC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J09 compound treatment 1.9298476E8 2.78E7 0.35 1.75379531E8 2.04E7 0.35 0.4934 1.0 3211080 TimTec1_002671 C/C(=N\Cc1ccccn1)/c2c(O)c3ccccc3n(c4ccccc4)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J10 compound treatment 1.70480964E8 5280000.0 0.07 1.23895998E8 -3.11E7 -0.53 -0.3293 -0.6143 3084079 TimTec1_002672 OCCNC(=O)C1=NN=CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J11 compound treatment 1.93767422E8 2.86E7 0.36 1.44705567E8 -1.03E7 -0.18 0.1291 0.3235 1667994 TimTec1_002673 CC1=NN(C(=O)c2ccco2)C(O)(C1)c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J12 compound treatment 1.83762832E8 1.86E7 0.23 2.00691436E8 4.57E7 0.78 0.718 0.8794 3211081 TimTec1_002674 OC(=O)CCCNC1=NC2(CCCC2)Cc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J13 compound treatment 1.63437952E8 -1760000.0 -0.02 1.82093138E8 2.71E7 0.46 0.3126 0.6726 3209107 TimTec1_002675 NC(CCCNC(=N)N)C(=O)O.OC(=O)CCCC[C@H]1SC[C@H]2NC(=O)N[C@@H]12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J14 compound treatment 1.95666972E8 3.05E7 0.38 1.7663357E8 2.17E7 0.37 0.5324 0.9999 1608879 TimTec1_002676 NN(C(=O)C1CCCCC1)c2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J15 compound treatment 2.12203751E8 4.7E7 0.59 1.37618541E8 -1.74E7 -0.3 0.2069 0.3133 1250350 TimTec1_002677 COc1cc(NC(=O)C)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J16 compound treatment 1.79769956E8 1.46E7 0.18 1.51581433E8 -3390000.0 -0.06 0.0882 0.4598 1447389 TimTec1_002678 Cn1cnc2n(Cc3ccccc3)c(=O)[nH]c(=S)c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J17 compound treatment 4.75132845E8 3.1E8 3.89 3.938175E8 2.39E8 4.09 5.6402 0.9997 1466505 TimTec1_002679 COCc1cc(O)n2c3ccccc3nc2c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J18 compound treatment 1.79104374E8 1.39E7 0.17 1.67675309E8 1.27E7 0.22 0.2771 0.994 1156263 TimTec1_002680 COC(=O)CC1(O)N(C(=CC1=O)c2ccc(C)cc2)c3ccccc3OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J19 compound treatment 1.94547942E8 2.93E7 0.37 1.76965754E8 2.2E7 0.38 0.5265 0.9999 1548500 TimTec1_002681 CC1(C)CCCC(C)(C)N1OC(=O)c2ccc(N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J20 compound treatment 1.43945284E8 -2.13E7 -0.27 1.38082263E8 -1.69E7 -0.29 -0.393 -0.9992 3084081 TimTec1_002682 OC1(NN=C2C=Cc3ccccc3N21)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J21 compound treatment 1.93411089E8 2.82E7 0.35 1.73989889E8 1.9E7 0.33 0.4804 0.9991 1276203 TimTec1_002683 CNC(C)c1ccc2OCCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J22 compound treatment 1.85881145E8 2.07E7 0.26 1.73364737E8 1.84E7 0.31 0.406 0.9954 3084083 TimTec1_002684 C(N1CCNCC1)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J23 mock treatment 1.87962149E8 2.28E7 0.29 1.1973869E8 -3.52E7 -0.6 -0.2246 -0.3366 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 J24 mock treatment 1.87104815E8 2.19E7 0.27 1.639231E8 8950000.0 0.15 0.3026 0.962 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K01 compound treatment 2.01914038E8 3.67E7 0.46 1.61148263E8 6180000.0 0.11 0.4004 0.8474 3209108 TimTec1_002685 COc1ccc(cc1)C(=O)CSc2nc3cc(C)ccc3cc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K02 compound treatment 2.12140094E8 4.69E7 0.59 1.51064691E8 -3910000.0 -0.07 0.369 0.6228 3084085 TimTec1_002686 CCOc1ccc(/C=N/c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K03 compound treatment 1.66876359E8 1670000.0 0.02 1.30838356E8 -2.41E7 -0.41 -0.2773 -0.6703 1247383 TimTec1_002687 O=C(CSc1nc2cccnc2[nH]1)NC3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K04 compound treatment 1.61115328E8 -4090000.0 -0.05 1.22362758E8 -3.26E7 -0.56 -0.431 -0.7688 3084087 TimTec1_002688 COc1cccc(/N=C/c2ccc(O)cc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K05 compound treatment 1.46021115E8 -1.92E7 -0.24 1.44227841E8 -1.07E7 -0.18 -0.3002 -0.9912 3209109 TimTec1_002689 O=C1CNC(=O)N1/N=C/c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K06 compound treatment 1.60015109E8 -5190000.0 -0.07 1.44393755E8 -1.06E7 -0.18 -0.1741 -0.9046 1409322 TimTec1_002690 OCc1ccccc1CNCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K07 compound treatment 2.08035164E8 4.28E7 0.54 1.37285495E8 -1.77E7 -0.3 0.1659 0.2689 3209110 TimTec1_002691 CCOC(=O)Cc1c(C)[nH]c2c(c(C)nn2c1=O)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K08 compound treatment 1.50711127E8 -1.45E7 -0.18 2.17625393E8 6.27E7 1.07 0.6298 0.579 3084090 TimTec1_002692 Cc1ccc(/N=C/c2c[nH]c3ccccc23)c(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K09 compound treatment 1.4346996E8 -2.17E7 -0.27 1.22346523E8 -3.26E7 -0.56 -0.5877 -0.9456 1411633 TimTec1_002693 CC(NC(=O)c1cc(oc1C)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K10 compound treatment 1.74741621E8 9540000.0 0.12 1.40314698E8 -1.47E7 -0.25 -0.0928 -0.3338 3084091 TimTec1_002694 NC(=O)c1ccccc1/N=C/c2ccc3ccccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K11 compound treatment 2.31972843E8 6.68E7 0.84 1.55408815E8 436000.0 0.01 0.5976 0.7134 3209111 TimTec1_002695 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc2cccc(c2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K12 compound treatment 1.4619904E8 -1.9E7 -0.24 1.54706855E8 -266000.0 0.0 -0.1718 -0.7205 3084157 TimTec1_002696 Cc1cc(C)cc(/N=C/c2cccc(OCc3ccccc3)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K13 compound treatment 1.26129416E8 -3.91E7 -0.49 1.43475963E8 -1.15E7 -0.2 -0.4857 -0.9197 3084159 TimTec1_002697 COC(=O)CNC(=O)c1cc[nH]n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K14 compound treatment 1.53246625E8 -1.2E7 -0.15 1.58709162E8 3740000.0 0.06 -0.0608 -0.3731 1444507 TimTec1_002698 Cc1ccc(s1)C2N(CCN2c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K15 compound treatment 1.85004538E8 1.98E7 0.25 1.55907341E8 934000.0 0.02 0.187 0.7511 3084162 TimTec1_002699 FC(F)(F)Oc1ccc(/N=C/c2ccc(Br)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K16 compound treatment 1.39114873E8 -2.61E7 -0.33 1.35347327E8 -1.96E7 -0.34 -0.469 -0.9999 1914768 TimTec1_002700 C(=N/c1cccc2c(\N=C\c3ccco3)cccc12)\c4ccco4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K17 compound treatment 1.8360581E8 1.84E7 0.23 1.13011919E8 -4.2E7 -0.72 -0.3447 -0.4568 3209112 TimTec1_002701 Cc1ccc2nc(sc2c1)c3ccc(NC(=O)Nc4ccccc4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K18 compound treatment 1.81564608E8 1.64E7 0.21 1.32418557E8 -2.26E7 -0.39 -0.1279 -0.2924 3209113 TimTec1_002702 Cc1ccc(/C=N/c2ccccc2OCc3ccccc3)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K19 compound treatment 1.98517388E8 3.33E7 0.42 2.07909292E8 5.29E7 0.91 0.9363 0.9382 3084165 TimTec1_002703 N#Cc1cc2CCCc2nc1SCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K20 compound treatment 1.48179417E8 -1.7E7 -0.21 1.46577681E8 -8400000.0 -0.14 -0.2526 -0.9814 1504412 TimTec1_002704 Fc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K21 compound treatment 1.90343386E8 2.51E7 0.32 1.44645941E8 -1.03E7 -0.18 0.098 0.2711 3084167 TimTec1_002705 CCOc1ccccc1/C=N/c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K22 compound treatment 1.40095428E8 -2.51E7 -0.31 1.71151583E8 1.62E7 0.28 -0.0269 -0.0641 3209114 TimTec1_002706 COc1cccc(c1)C(=O)N2N=C(O)C=CC2=C(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K23 mock treatment 1.85786949E8 2.06E7 0.26 1.46404966E8 -8570000.0 -0.15 0.0789 0.2656 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 K24 mock treatment 1.41763201E8 -2.34E7 -0.29 1.94302377E8 3.93E7 0.67 0.2681 0.365 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L01 compound treatment 1.52606058E8 -1.26E7 -0.16 1.30230945E8 -2.47E7 -0.42 -0.4112 -0.9097 1454168 TimTec1_002707 COc1cc(OC)nc(n1)C(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L02 compound treatment 1.21210955E8 -4.4E7 -0.55 1.26559652E8 -2.84E7 -0.49 -0.7341 -0.998 1013845 TimTec1_002708 OC(=O)C1CCN(CC1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L03 compound treatment 1.14159714E8 -5.1E7 -0.64 1.17894498E8 -3.71E7 -0.63 -0.9016 -1.0 3084171 TimTec1_002709 SC1=N(/N=C/2\C(=O)Nc3ccccc23)C(=O)C4C=CC=CC4=N1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L04 compound treatment 1.32157771E8 -3.3E7 -0.41 1.16595188E8 -3.84E7 -0.66 -0.7576 -0.9753 1202182 TimTec1_002710 NC1=C(C#N)C(=C(C#N)C#N)C(O1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L05 compound treatment 1.36841067E8 -2.84E7 -0.36 1.11374785E8 -4.36E7 -0.75 -0.7793 -0.9426 1265429 TimTec1_002711 CC1(C)CC(=O)C(C(C2C(=O)CC(C)(C)CC2=O)c3ccc(F)cc3O)C(=O)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L06 compound treatment 1.30800347E8 -3.44E7 -0.43 1.38226215E8 -1.67E7 -0.29 -0.5079 -0.9803 3084174 TimTec1_002712 COc1ccc(cc1OC)/C(=N/O)/c2nccc3cc(OC)c(OC)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L07 compound treatment 9.2965315E7 -7.22E7 -0.91 7.5042729E7 -7.99E7 -1.37 -1.6083 -0.98 1260243 TimTec1_002713 S=c1nc(c2ccco2)c3c(=S)[nH]c(=S)[nH]c3[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L08 compound treatment 1.7442849E8 9230000.0 0.12 1.32389525E8 -2.26E7 -0.39 -0.1915 -0.4746 1599464 TimTec1_002714 CC1CN(CCC1=O)C2CC(C)(C)NC(C)(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L09 compound treatment 1.03011827E8 -6.22E7 -0.78 1.06606827E8 -4.84E7 -0.83 -1.1371 -0.9996 1384770 TimTec1_002715 CN(C)c1ccc(cc1)C2OCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L10 compound treatment 1.30932515E8 -3.43E7 -0.43 1.20671714E8 -3.43E7 -0.59 -0.7192 -0.9883 1608667 TimTec1_002716 NC(=O)CNC(=O)c1ccc2ccccc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L11 compound treatment 1.83970672E8 1.88E7 0.24 1.71749062E8 1.68E7 0.29 0.3695 0.9951 3209115 TimTec1_002717 COC(=O)CNS(=O)(=O)Nc1ccc(cc1)c2nc3ccc(C)cc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L12 compound treatment 8.6661351E7 -7.85E7 -0.99 9.6296426E7 -5.87E7 -1.0 -1.4069 -1.0 1678540 TimTec1_002718 Clc1ccc2n(CCC(=O)n3c(=O)oc4cc(Cl)ccc34)c(=O)oc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L13 compound treatment 1.31309095E8 -3.39E7 -0.43 1.77385602E8 2.24E7 0.38 -0.0294 -0.0513 1920767 TimTec1_002719 Cc1cc(c2ccco2)n(n1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L14 compound treatment 1.17285476E8 -4.79E7 -0.6 1.42356703E8 -1.26E7 -0.22 -0.5777 -0.9046 3084178 TimTec1_002720 CCOC(=O)Cc1nnn[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L15 compound treatment 1.18118667E8 -4.71E7 -0.59 1.21261775E8 -3.37E7 -0.58 -0.8257 -0.9999 3209116 TimTec1_002721 Brc1ccc(cc1)C(=S)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L16 compound treatment 1.36935908E8 -2.83E7 -0.35 1.48793679E8 -6180000.0 -0.11 -0.3255 -0.8797 1354769 TimTec1_002722 CC(C)COC(=O)NCc1ccc2OCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L17 compound treatment 1.38047936E8 -2.72E7 -0.34 1.71636121E8 1.67E7 0.29 -0.0392 -0.0882 3209117 TimTec1_002723 Cc1ccc(cc1)[C@H]2[C@@H](C#N)[C@H](C#N)N3CCCN23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L18 compound treatment 1.29420569E8 -3.58E7 -0.45 1.42704596E8 -1.23E7 -0.21 -0.4659 -0.9401 71735 TimTec1_002724 COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L19 compound treatment 1.30201708E8 -3.5E7 -0.44 1.43951119E8 -1.1E7 -0.19 -0.4439 -0.9288 3084252 TimTec1_002725 CC1(C)OC(=O)N(C1=C)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L20 compound treatment 1.37562982E8 -2.76E7 -0.35 2.07702717E8 5.27E7 0.9 0.3931 0.4065 3084253 TimTec1_002726 CC(=O)N1C2CC(C=C2)C1(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L21 compound treatment 1.26039379E8 -3.92E7 -0.49 1.29928097E8 -2.5E7 -0.43 -0.6505 -0.9977 1279868 TimTec1_002727 CCc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L22 compound treatment 1.66004617E8 803000.0 0.01 1.46517199E8 -8460000.0 -0.14 -0.0952 -0.6563 1355496 TimTec1_002728 Cc1ccc(CSCC(=O)Nc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L23 mock treatment 1.24368357E8 -4.08E7 -0.51 1.75949148E8 2.1E7 0.36 -0.1083 -0.1731 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 L24 mock treatment 1.53156226E8 -1.2E7 -0.15 1.4553938E8 -9430000.0 -0.16 -0.221 -0.9994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M01 compound treatment 1.86869198E8 2.17E7 0.27 1.68941438E8 1.4E7 0.24 0.3613 0.998 1520938 TimTec1_002729 Cn1c2ccccc2c3nn(c4ccccc4)c(=O)cc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M02 compound treatment 1.88054923E8 2.29E7 0.29 1.76248313E8 2.13E7 0.36 0.4602 0.993 3209118 TimTec1_002730 NS(=O)(=O)c1ccc(/N=C/c2c3ccccc3cc4ccccc24)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M03 compound treatment 1.89708087E8 2.45E7 0.31 1.78708078E8 2.37E7 0.41 0.5047 0.9905 3084256 TimTec1_002731 CC(C)(C)c1ccc(OCCNC(=O)c2cccc(Br)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M04 compound treatment 1.85646508E8 2.04E7 0.26 1.98041872E8 4.31E7 0.74 0.7027 0.9002 3209119 TimTec1_002732 O=C(Nc1cccc(C#N)c1)/C=C/c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M05 compound treatment 1.68988397E8 3790000.0 0.05 1.63359261E8 8390000.0 0.14 0.1351 0.8934 3084258 TimTec1_002733 Cc1ccc(cc1)N2C(SCC2=O)/C=C/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M06 compound treatment 2.1618379E8 5.1E7 0.64 1.98764552E8 4.38E7 0.75 0.9823 0.9969 3209120 TimTec1_002734 C=CCC1(CC=C)CCCCN1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M07 compound treatment 2.2552472E8 6.03E7 0.76 2.07571757E8 5.26E7 0.9 1.1717 0.9963 3209121 TimTec1_002735 Cc1nc(NCc2ccco2)c3cc(sc3n1)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M08 compound treatment 2.140954E8 4.89E7 0.61 1.05388989E8 -4.96E7 -0.85 -0.1665 -0.159 3084261 TimTec1_002736 Ic1ccc(/N=C/c2ccc(C#N)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M09 compound treatment 2.06370175E8 4.12E7 0.52 1.5168764E8 -3290000.0 -0.06 0.3254 0.6264 3209238 TimTec1_002737 COc1ccc(OC)c(/C=c/2\sc3nnc(c4ccccc4Cl)n3c2=O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M10 compound treatment 2.11527019E8 4.63E7 0.58 1.90891821E8 3.59E7 0.61 0.8457 0.9996 3084262 TimTec1_002738 COc1ccc(/N=C/c2ccccc2OCc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M11 compound treatment 1.4695148E8 -1.83E7 -0.23 1.64608361E8 9640000.0 0.16 -0.0453 -0.1604 3209239 TimTec1_002739 C/C(=N/CCO)/c1c([nH]n(c2nc3ccccc3s2)c1=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M12 compound treatment 2.04722452E8 3.95E7 0.5 1.97454615E8 4.25E7 0.73 0.8648 0.9826 3084263 TimTec1_002740 Cc1ccccc1/C=N/c2ccccc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M13 compound treatment 2.01373527E8 3.62E7 0.45 2.02878203E8 4.79E7 0.82 0.9007 0.9611 3209240 TimTec1_002741 COC(=O)N(C)c1ccccc1C(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M14 compound treatment 1.93042723E8 2.78E7 0.35 1.90650462E8 3.57E7 0.61 0.6788 0.9648 3084265 TimTec1_002742 CCCOC(=O)c1ccc(/N=C/c2ccc(C)s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M15 compound treatment 2.07075313E8 4.19E7 0.53 1.88004109E8 3.3E7 0.57 0.7712 0.9993 1321825 TimTec1_002743 CC(Oc1ccc(Cl)cc1Cl)C(=O)NN2C(=O)c3ccccc3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M16 compound treatment 1.70241118E8 5040000.0 0.06 1.6557518E8 1.06E7 0.18 0.173 0.9003 3084267 TimTec1_002744 COc1cc(/C=N/c2ccc(cc2)C(=O)c3ccccc3)cc(OC)c1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M17 compound treatment 2.06629625E8 4.14E7 0.52 1.85192817E8 3.02E7 0.52 0.7333 1.0 1712191 TimTec1_002745 Cc1ccc(cc1I)C(=O)Nc2ccc(Oc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M18 compound treatment 1.65718652E8 517000.0 0.01 1.7419759E8 1.92E7 0.33 0.2373 0.7209 3209241 TimTec1_002746 CCCC(=O)c1ccc(/N=C/c2ccc(Cl)cc2Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M19 compound treatment 1.8734215E8 2.21E7 0.28 1.45422594E8 -9550000.0 -0.16 0.0808 0.2507 3084269 TimTec1_002747 Brc1ccc(/C=N/c2ccccc2C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M20 compound treatment 1.81881794E8 1.67E7 0.21 1.31238245E8 -2.37E7 -0.41 -0.1393 -0.3049 1423653 TimTec1_002748 COc1ccc(NC(=O)c2ccc(Cn3cc(Cl)cn3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M21 compound treatment 2.16202335E8 5.1E7 0.64 1.40584162E8 -1.44E7 -0.25 0.2782 0.4058 3084271 TimTec1_002749 Cc1nn(C(=S)N)c(O)c1C(C(C#N)C#N)c2cccc(Cl)c2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M22 compound treatment 1.96160317E8 3.1E7 0.39 1.79928988E8 2.5E7 0.43 0.5767 0.9989 3209242 TimTec1_002750 NC(=O)Oc1ccc(I)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M23 mock treatment 1.36208259E8 -2.9E7 -0.36 1.03541327E8 -5.14E7 -0.88 -0.8797 -0.9235 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 M24 mock treatment 1.84873698E8 1.97E7 0.25 1.32614053E8 -2.24E7 -0.38 -0.0961 -0.2111 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N01 compound treatment 1.78674433E8 1.35E7 0.17 1.92697158E8 3.77E7 0.65 0.5761 0.8631 3083254 TimTec1_002751 Cc1cc2nnc(c3cccc4OCOc43)n2c5ccccc15 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N02 compound treatment 1.91303328E8 2.61E7 0.33 1.83295888E8 2.83E7 0.48 0.5744 0.9817 3083257 TimTec1_002752 C/C=C\1/C(C)C(C(=C(N)N1c2ccc(cc2)C(=O)N)C#N)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N03 compound treatment 1.47524805E8 -1.77E7 -0.22 2.00101307E8 4.51E7 0.77 0.3894 0.4846 1231981 TimTec1_002753 Cc1ccc(cc1)C(=O)Cc2nc3ncccc3[nH]c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N04 compound treatment 1.21436055E8 -4.38E7 -0.55 1.95786895E8 4.08E7 0.7 0.1058 0.1191 1274147 TimTec1_002754 Sc1nc(CCN2C(=O)c3ccccc3C2=O)n[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N05 compound treatment 2.10522801E8 4.53E7 0.57 1.44907408E8 -1.01E7 -0.17 0.2802 0.4716 3083260 TimTec1_002755 CC(=S)N1CCN(CC1)C(=S)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N06 compound treatment 1.53879135E8 -1.13E7 -0.14 1.4253728E8 -1.24E7 -0.21 -0.251 -0.9807 1517166 TimTec1_002756 Cc1ccccc1N2C(=O)c3ccccc3NC2(C)CC(=O)NCc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N07 compound treatment 1.3483665E8 -3.04E7 -0.38 7.7247908E7 -7.77E7 -1.33 -1.2102 -0.8744 1118059 TimTec1_002757 Nn1c(=O)c(Cc2ccco2)n[nH]c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N08 compound treatment 1.94972137E8 2.98E7 0.37 1.49598226E8 -5370000.0 -0.09 0.199 0.5174 1361841 TimTec1_002758 CCOC(=O)C1=C(NC(=S)C(CC=C)(C#N)C1c2cccnc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N09 compound treatment 2.05658781E8 4.05E7 0.51 1.43150665E8 -1.18E7 -0.2 0.2158 0.3949 3083263 TimTec1_002759 COC(=O)CNc1cc(C)c(cc1OC)C(O)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N10 compound treatment 1.24818894E8 -4.04E7 -0.51 1.99669858E8 4.47E7 0.77 0.1828 0.1992 1187305 TimTec1_002760 CCCC(=O)Nc1ccc2[nH]c(=O)[nH]c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N11 compound treatment 1.24485863E8 -4.07E7 -0.51 1.68071685E8 1.31E7 0.22 -0.2026 -0.3632 1455249 TimTec1_002761 CC(=O)Oc1ccc2occ(C(=O)c3ccc(F)cc3)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N12 compound treatment 2.09654129E8 4.45E7 0.56 2.04585258E8 4.96E7 0.85 0.9948 0.9792 1149353 TimTec1_002762 COc1ccc(cc1)C(C#N)N2N=C(C)CC2(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N13 compound treatment 1.15782599E8 -4.94E7 -0.62 1.10342386E8 -4.46E7 -0.76 -0.9786 -0.9946 1491757 TimTec1_002763 Clc1cccc(NC(=O)C(NC=O)c2ccccc2Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N14 compound treatment 1.92556739E8 2.74E7 0.34 1.3489741E8 -2.01E7 -0.34 -4.0E-4 -7.0E-4 3209243 TimTec1_002764 OC(=O)[C@@H]1CCCN1Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N15 compound treatment 1.4003644E8 -2.52E7 -0.32 1.09484074E8 -4.55E7 -0.78 -0.7738 -0.921 3083267 TimTec1_002765 OC(=O)CCc1nnc(S)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N16 compound treatment 2.16924425E8 5.17E7 0.65 1.34757806E8 -2.02E7 -0.35 0.2141 0.2912 1446498 TimTec1_002766 O=C(NC1CCCCCCCCCCC1)c2nc[nH]n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N17 compound treatment 2.08383726E8 4.32E7 0.54 1.31002573E8 -2.4E7 -0.41 0.0929 0.1367 3209244 TimTec1_002767 COc1ccc(cc1)[C@H]2[C@@H](C#N)[C@H](C#N)N3CCCN23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N18 compound treatment 1.95746296E8 3.05E7 0.38 1.06538655E8 -4.84E7 -0.83 -0.3153 -0.3452 1206859 TimTec1_002768 Brc1cncc(c1)C(=O)Nc2ccc(cc2)C(=O)NC3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N19 compound treatment 1.92442632E8 2.72E7 0.34 1.33040615E8 -2.19E7 -0.38 -0.0238 -0.047 1560261 TimTec1_002769 COc1ccc(cc1)C2NCCc3cc(OC)c(OC)cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N20 compound treatment 1.87502468E8 2.23E7 0.28 1.80592555E8 2.56E7 0.44 0.5079 0.9764 3209245 TimTec1_002770 CN(C)c1nc(NCc2ccccc2)nc(Nc3ccc(OC(F)(F)F)cc3)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N21 compound treatment 1.82219829E8 1.7E7 0.21 1.88200409E8 3.32E7 0.57 0.5531 0.9105 1425208 TimTec1_002771 CN(CC(=O)O)S(=O)(=O)c1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N22 compound treatment 1.738478E8 8650000.0 0.11 1.49445194E8 -5530000.0 -0.09 0.0098 0.068 3209246 TimTec1_002772 Nn1c(CSCc2ccccc2)nnc1CSCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N23 mock treatment 1.83539104E8 1.83E7 0.23 1.76976441E8 2.2E7 0.38 0.429 0.972 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 N24 mock treatment 1.90846268E8 2.56E7 0.32 1.76019315E8 2.1E7 0.36 0.4822 0.9984 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O01 compound treatment 2.02179449E8 3.7E7 0.46 1.68252623E8 1.33E7 0.23 0.4887 0.9461 3083272 TimTec1_002773 C(Nc1nonc1c2ncon2)n3nnc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O02 compound treatment 1.85054984E8 1.99E7 0.25 1.64132658E8 9160000.0 0.16 0.287 0.9751 3209247 TimTec1_002774 O=C(NC1CCCCC1)/C=C/c2cccc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O03 compound treatment 1.82063055E8 1.69E7 0.21 1.55735173E8 762000.0 0.01 0.1588 0.7493 3209248 TimTec1_002775 O=C(NCCc1ccccc1)c2c(/N=C/3\C(=O)Nc4ccccc34)sc5CCCCc25 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O04 compound treatment 2.03799534E8 3.86E7 0.48 9.250364E7 -6.25E7 -1.07 -0.4138 -0.3525 1468374 TimTec1_002776 OC(c1cccs1)c2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O05 compound treatment 1.83153713E8 1.8E7 0.23 1.32471095E8 -2.25E7 -0.39 -0.1131 -0.2535 3209249 TimTec1_002777 Clc1ccc(Cl)c(c1)N2C(SCC2=O)/C=C/c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O06 compound treatment 1.93404696E8 2.82E7 0.35 1.76675711E8 2.17E7 0.37 0.5129 0.9997 1257164 TimTec1_002778 Cc1ccc(C)c(NCc2ccccc2CO)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O07 compound treatment 1.94473841E8 2.93E7 0.37 1.63272592E8 8300000.0 0.14 0.3601 0.9146 3083858 TimTec1_002779 Cc1nc2ccccc2nc1Sc3nnc(o3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O08 compound treatment 2.03351132E8 3.81E7 0.48 1.21019761E8 -3.4E7 -0.58 -0.0726 -0.0964 1918856 TimTec1_002780 Brc1ccc(/C=N/c2cccc3ccccc23)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O09 compound treatment 1.69648529E8 4450000.0 0.06 1.56208891E8 1240000.0 0.02 0.0544 0.9119 3209250 TimTec1_002781 COc1ccc(Br)cc1/C=C/2\C(=O)NC(=O)N(CCC3=CCCCC3)C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O10 compound treatment 1.91427718E8 2.62E7 0.33 1.62792351E8 7820000.0 0.13 0.3273 0.9215 3209251 TimTec1_002782 N#Cc1ccc(/C=N/c2cccc(C#N)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O11 compound treatment 1.96396852E8 3.12E7 0.39 1.19113671E8 -3.59E7 -0.61 -0.1573 -0.2161 3083924 TimTec1_002783 CCN1C(=C)c2cc(C)cc(C)c2NC1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O12 compound treatment 1.82679777E8 1.75E7 0.22 1.18326132E8 -3.66E7 -0.63 -0.2885 -0.4342 3209252 TimTec1_002784 COc1ccc2ccccc2c1/C=N/c3ccccc3C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O13 compound treatment 1.91060651E8 2.59E7 0.32 1.49691581E8 -5280000.0 -0.09 0.1654 0.4913 1178846 TimTec1_002785 C=CCSc1nc2ccccc2c(=O)n1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O14 compound treatment 2.13967807E8 4.88E7 0.61 1.82531092E8 2.76E7 0.47 0.7661 0.9918 3209253 TimTec1_002786 Cc1ccc(/C=N/c2ccc(\N=C\c3ccc(C)s3)cc2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O15 compound treatment 1.5714615E8 -8060000.0 -0.1 1.04163832E8 -5.08E7 -0.87 -0.6865 -0.784 1364793 TimTec1_002787 CC(Oc1ccc(Cl)cc1Cl)C(=O)Nc2sc(C)c(C)c2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O16 compound treatment 1.79163565E8 1.4E7 0.18 1.65943987E8 1.1E7 0.19 0.2566 0.9994 3209254 TimTec1_002788 Cc1c(Cc2ccccc2)sc(/N=C/c3ccc(Cl)cc3)c1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O17 compound treatment 1.79287635E8 1.41E7 0.18 1.77715973E8 2.27E7 0.39 0.4002 0.9361 1685792 TimTec1_002789 COc1ccc2c(Cl)c(sc2c1)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O18 compound treatment 1.82974486E8 1.78E7 0.22 1.54424453E8 -549000.0 -0.01 0.151 0.6767 1138448 TimTec1_002790 O=C(CSc1nc2CCCCc2cc1C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O19 compound treatment 2.14206461E8 4.9E7 0.61 1.91790348E8 3.68E7 0.63 0.8803 0.9999 3083928 TimTec1_002791 CSc1ccc(/C=N/c2ccc(C)c(C)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O20 compound treatment 1.75074145E8 9870000.0 0.12 1.46887593E8 -8090000.0 -0.14 -0.0103 -0.0554 1253093 TimTec1_002792 CCOc1cccc(=O)c2c(C)n(c(C)c12)c3ccc(OC)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O21 compound treatment 2.04500778E8 3.93E7 0.49 2.03742624E8 4.88E7 0.83 0.9389 0.9684 3083930 TimTec1_002793 Cc1ccc(/C=N/c2ccc3ccccc3c2)o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O22 compound treatment 1.88034438E8 2.28E7 0.29 1.72621082E8 1.76E7 0.3 0.4161 0.9996 3209255 TimTec1_002794 C/C(=N/Cc1nnc(C)s1)/c2cc3c(=O)n(C)c4ccccc4c3oc2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O23 mock treatment 1.86343386E8 2.11E7 0.27 1.64967497E8 9990000.0 0.17 0.3085 0.9775 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 O24 mock treatment 1.96168734E8 3.1E7 0.39 1.50485729E8 -4490000.0 -0.08 0.2204 0.5565 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P01 compound treatment 1.95579203E8 3.04E7 0.38 1.61754951E8 6780000.0 0.12 0.3515 0.8825 3083932 TimTec1_002795 CC1=CC(=O)N(C1=O)c2c(C)n(C)n(c3ccccc3)c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P02 compound treatment 1.8667512E8 2.15E7 0.27 1.41021491E8 -1.4E7 -0.24 0.0216 0.06 3209256 TimTec1_002796 CNC(=O)C1=CC(C)(C)NC1(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P03 compound treatment 2.09654823E8 4.45E7 0.56 1.33589383E8 -2.14E7 -0.37 0.1355 0.2031 1174268 TimTec1_002797 Clc1ccc(cc1)C(=O)C(=C2NCCN2)n3ccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P04 compound treatment 1.5461739E8 -1.06E7 -0.13 1.55588882E8 616000.0 0.01 -0.0864 -0.6489 1414675 TimTec1_002798 O=C(N1CCOCC1)c2ccc(s2)C(=O)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P05 compound treatment 2.12717519E8 4.75E7 0.6 1.6625244E8 1.13E7 0.19 0.558 0.8906 1495833 TimTec1_002799 COc1ccc(cc1OC)C2=NCC(C)(C)CO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P06 compound treatment 1.96681255E8 3.15E7 0.39 1.6288208E8 7910000.0 0.14 0.375 0.8982 1678629 TimTec1_002800 COc1ccccc1C(=O)Nc2ccc(cc2)c3cn4ccccc4n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P07 compound treatment 2.02603596E8 3.74E7 0.47 1.89185674E8 3.42E7 0.59 0.7459 0.994 3209373 TimTec1_002801 CCn1c(=O)c(C/2=NNC(=O)\C2=C/Nc3nccs3)c(O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P08 compound treatment 1.80137979E8 1.49E7 0.19 1.28991799E8 -2.6E7 -0.44 -0.182 -0.3771 1514165 TimTec1_002802 COc1ccc(cc1)C(C#N)N2CCC(=N2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P09 compound treatment 1.82104199E8 1.69E7 0.21 1.26325953E8 -2.86E7 -0.49 -0.1968 -0.3684 1619442 TimTec1_002803 Nc1cccc(c1)C(=O)OC2CSC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P10 compound treatment 1.74885222E8 9680000.0 0.12 1.62349899E8 7380000.0 0.13 0.1752 0.9998 3209374 TimTec1_002804 Cc1ccc(OCCSc2ncnc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P11 compound treatment 1.86303968E8 2.11E7 0.26 1.85013104E8 3.0E7 0.51 0.5508 0.9523 1011278 TimTec1_002805 OC(=O)CNC(=O)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P12 compound treatment 1.54991234E8 -1.02E7 -0.13 1.71399407E8 1.64E7 0.28 0.1083 0.3504 1159913 TimTec1_002806 NC(=O)Cc1nc(cs1)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P13 compound treatment 1.74133937E8 8930000.0 0.11 1.77366782E8 2.24E7 0.38 0.3503 0.8771 1445633 TimTec1_002807 CCC(=O)c1cc2OCCOc2cc1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P14 compound treatment 2.0032706E8 3.51E7 0.44 1.78423827E8 2.35E7 0.4 0.5954 0.9989 1468490 TimTec1_002808 Clc1ccccc1CS(=O)(=O)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P15 compound treatment 1.98789825E8 3.36E7 0.42 1.30483609E8 -2.45E7 -0.42 0.0015 0.0025 1633493 TimTec1_002809 NC(=O)CSc1nc2ccccc2c(=O)n1Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P16 compound treatment 1.97919325E8 3.27E7 0.41 1.90205807E8 3.52E7 0.6 0.7167 0.9824 1674139 TimTec1_002810 CCOC(=O)C1CCN(CC1)C(=O)c2ccccc2NC(=O)c3cccc(F)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P17 compound treatment 2.12068107E8 4.69E7 0.59 1.11498675E8 -4.35E7 -0.74 -0.1105 -0.1165 1703140 TimTec1_002811 OC(=O)CC1(O)N(Cc2ccccc2)C(=O)c3ccccc31 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P18 compound treatment 2.46571249E8 8.14E7 1.02 2.25579392E8 7.06E7 1.21 1.5764 0.9965 3084009 TimTec1_002812 COC(=O)C1=CN(CC2CCCO2)C=C(C1c3ccccc3)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P19 compound treatment 1.83684288E8 1.85E7 0.23 1.60142813E8 5170000.0 0.09 0.2265 0.9128 1281947 TimTec1_002813 CC1(C)CC(=C(C(C(C#N)C(=S)N)c2ccc(Cl)cc2)C(=O)C1)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P20 compound treatment 1.64208763E8 -993000.0 -0.01 1.38893154E8 -1.61E7 -0.28 -0.2034 -0.7384 3084012 TimTec1_002814 O=C(C1CCCC1)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P21 compound treatment 1.88401579E8 2.32E7 0.29 1.64671633E8 9700000.0 0.17 0.3232 0.9646 1667550 TimTec1_002815 Clc1ccccc1C(=O)N2CC(CC2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P22 compound treatment 1.91480714E8 2.63E7 0.33 1.7748847E8 2.25E7 0.39 0.5056 0.997 3209375 TimTec1_002816 CC(=O)NC(N1CCCCC1c2cccnc2)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P23 mock treatment 1.29454054E8 -3.57E7 -0.45 1.49284803E8 -5690000.0 -0.1 -0.3859 -0.841 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2070 P24 mock treatment 1.84949057E8 1.97E7 0.25 1.61367588E8 6390000.0 0.11 0.2526 0.9326 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A01 compound treatment 1.6054587E8 1.77E7 0.22 1.54866847E8 4220000.0 0.07 0.2081 0.8912 3084014 TimTec1_002817 COCCc1nnc(CCOC)n1N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A02 compound treatment 1.6310597E8 2.03E7 0.25 1.6681312E8 1.62E7 0.28 0.3755 0.9991 3084016 TimTec1_002818 COC(=O)Cc1[nH]nc2OC(=C(C#N)C3(CCOC3C)c12)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A03 compound treatment 1.62398511E8 1.96E7 0.25 1.86094446E8 3.55E7 0.61 0.6026 0.9206 1505030 TimTec1_002819 CC(=O)NC1CC(C)(C)N(OC(=O)c2ccccn2)C(C)(C)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A04 compound treatment 1.67194856E8 2.44E7 0.31 1.74712849E8 2.41E7 0.41 0.5073 0.9892 1622909 TimTec1_002820 COc1cccc(NC(=O)CCC(=O)Nc2cccc(OC)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A05 compound treatment 1.64709751E8 2.19E7 0.27 1.50436084E8 -208000.0 0.0 0.1914 0.6979 1232935 TimTec1_002821 COC(=O)c1ccc2OCC(=O)Nc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A06 compound treatment 1.7035287E8 2.75E7 0.35 1.60739587E8 1.01E7 0.17 0.3662 0.9489 1338496 TimTec1_002822 O=C(Cc1ccccc1)Nc2ccc(C#N)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A07 compound treatment 1.72112848E8 2.93E7 0.37 1.74313303E8 2.37E7 0.41 0.5461 0.9988 1686991 TimTec1_002823 O=C(NC1(CC1)c2ccccc2)N3CCN(CC3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A08 compound treatment 1.73703057E8 3.09E7 0.39 1.64255075E8 1.36E7 0.23 0.4385 0.9705 1704723 TimTec1_002824 COc1ccccc1OCC(=O)NCCC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A09 compound treatment 1.58191808E8 1.53E7 0.19 1.97112985E8 4.65E7 0.8 0.6986 0.8536 1538860 TimTec1_002825 COc1nc(C#N)nc(n1)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A10 compound treatment 1.2719829E8 -1.56E7 -0.2 1.69873892E8 1.92E7 0.33 0.094 0.2452 1705636 TimTec1_002826 COC(=O)CCC(=O)c1c(C)[nH]c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A11 compound treatment 1.66549054E8 2.37E7 0.3 1.62771661E8 1.21E7 0.21 0.3571 0.9846 1667965 TimTec1_002827 O=C(N1CC(=O)N(CCc2ccccc2)C(=O)C1)C3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A12 compound treatment 2.01395827E8 5.86E7 0.73 1.68782529E8 1.81E7 0.31 0.7389 0.9266 1335542 TimTec1_002828 NS(=O)(=O)c1ccc(NC(=O)C2CC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A13 compound treatment 1.79174767E8 3.63E7 0.46 1.86625012E8 3.6E7 0.62 0.7578 0.989 1346198 TimTec1_002829 CC(=O)Nc1ccc(NC(=O)NC2(CC2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A14 compound treatment 1.68213061E8 2.54E7 0.32 1.58903409E8 8260000.0 0.14 0.325 0.9333 1605519 TimTec1_002830 COc1ccc(cc1)C(=O)NCCC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A15 compound treatment 1.77860644E8 3.5E7 0.44 1.64962944E8 1.43E7 0.25 0.4839 0.962 1396894 TimTec1_002831 CC(=O)ON1C(C)(C)CC(CC1(C)C)OC(=O)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A16 compound treatment 1.39524101E8 -3320000.0 -0.04 1.8398522E8 3.33E7 0.57 0.3741 0.6538 1437131 TimTec1_002832 COc1ccc(NC(=S)NC(=O)COc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A17 compound treatment 1.82010393E8 3.92E7 0.49 1.67852154E8 1.72E7 0.29 0.5557 0.9701 3209376 TimTec1_002833 CC(CN(C)C)Sc1nc(C)cc(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A18 compound treatment 1.03485596E8 -3.94E7 -0.49 1.42720388E8 -7920000.0 -0.14 -0.445 -0.8692 3084025 TimTec1_002834 C/C(=N/O)/C1C(=O)c2ccccc2C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A19 compound treatment 1.68410122E8 2.56E7 0.32 1.75611946E8 2.5E7 0.43 0.529 0.99 1530326 TimTec1_002835 O=C(Cn1nc2-c3ccccc3C(=O)c4cccc1c24)N5CCOCC5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A20 compound treatment 2.09768941E8 6.69E7 0.84 1.19829498E8 -3.08E7 -0.53 0.2207 0.2226 1340976 TimTec1_002836 Cc1ccccc1NCC(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A21 compound treatment 1.9339853E8 5.06E7 0.63 1.64120407E8 1.35E7 0.23 0.6116 0.9062 1679889 TimTec1_002837 CC(=O)Nc1ccc2c(C)cc(=O)[nH]c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A22 compound treatment 1.67474236E8 2.46E7 0.31 1.33861478E8 -1.68E7 -0.29 0.0153 0.0364 1127034 TimTec1_002838 OC(=O)CCC(=O)NC1CCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A23 mock treatment 1.1500445E8 -2.78E7 -0.35 1.61947773E8 1.13E7 0.19 -0.1101 -0.2758 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 A24 mock treatment 1.63150906E8 2.03E7 0.25 1.66874344E8 1.62E7 0.28 0.3766 0.9991 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B01 compound treatment 1.53293469E8 1.05E7 0.13 1.86675315E8 3.6E7 0.62 0.5288 0.8387 1361487 TimTec1_002839 CCC(=O)Nc1ccccc1c2ccccc2NC(=O)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B02 compound treatment 1.25715863E8 -1.71E7 -0.21 1.75420358E8 2.48E7 0.42 0.148 0.3112 3209377 TimTec1_002840 COc1ccc(CC(=O)N(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B03 compound treatment 1.83856041E8 4.1E7 0.51 1.24698351E8 -2.59E7 -0.44 0.0497 0.0732 3209378 TimTec1_002841 O=C(NCCCc1ccccc1)C2c3ccccc3Oc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B04 compound treatment 1.17564361E8 -2.53E7 -0.32 1.04085469E8 -4.66E7 -0.8 -0.7878 -0.9184 1049258 TimTec1_002842 O=C(N1CCN(CC1)c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B05 compound treatment 9.5710847E7 -4.71E7 -0.59 1.00374138E8 -5.03E7 -0.86 -1.0266 -0.9832 3084098 TimTec1_002843 O=C(CCCc1ccccc1)Nc2scc3c(=O)oc4ccccc4c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B06 compound treatment 1.01376144E8 -4.15E7 -0.52 1.11115499E8 -3.95E7 -0.68 -0.8463 -0.9916 1415764 TimTec1_002844 CCC(C)NC(=O)Cc1ccc(OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B07 compound treatment 1.1892226E8 -2.39E7 -0.3 1.23067215E8 -2.76E7 -0.47 -0.546 -0.9761 3209379 TimTec1_002845 Ic1cccc(c1)C(=O)Nc2ccccc2C(=O)N3CCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B08 compound treatment 1.63546468E8 2.07E7 0.26 1.07616403E8 -4.3E7 -0.74 -0.3372 -0.4317 1699287 TimTec1_002846 CCOC(=O)N1CCN(CC1)C(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B09 compound treatment 1.53873775E8 1.1E7 0.14 1.49869009E8 -775000.0 -0.01 0.0885 0.6364 3209380 TimTec1_002847 Cc1ccc(cc1)n2c(SCc3cccc(c3)C(F)(F)F)nnc2c4ccncc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B10 compound treatment 1.25266211E8 -1.76E7 -0.22 1.24925856E8 -2.57E7 -0.44 -0.4672 -0.9489 1149703 TimTec1_002848 COc1ccc(cc1)S(=O)(=O)N(CCO)C2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B11 compound treatment 1.15108611E8 -2.77E7 -0.35 1.68853541E8 1.82E7 0.31 -0.0256 -0.0548 3209381 TimTec1_002849 FC(F)(F)c1ccc(/C=N\n2c(S)nnc2c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B12 compound treatment 1.45447133E8 2600000.0 0.03 1.19556635E8 -3.11E7 -0.53 -0.3532 -0.6625 1570349 TimTec1_002850 CS(=O)(=O)NC1CCN(Cc2ccccc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B13 compound treatment 1.1621239E8 -2.66E7 -0.33 1.26477361E8 -2.42E7 -0.41 -0.5287 -0.9944 1666129 TimTec1_002851 CN(C)CCc1[nH]c2ccc(C)cc2c1CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B14 compound treatment 1.2900848E8 -1.38E7 -0.17 1.73539933E8 2.29E7 0.39 0.1544 0.3603 3084104 TimTec1_002852 CC(C)(C)NS(=O)(=O)c1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B15 compound treatment 1.09007833E8 -3.38E7 -0.42 1.62073743E8 1.14E7 0.2 -0.1618 -0.3462 1361349 TimTec1_002853 CC(=O)N1CC2N(CCc3ccccc23)C1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B16 compound treatment 1.25678865E8 -1.72E7 -0.22 1.06851977E8 -4.38E7 -0.75 -0.6823 -0.8748 1603417 TimTec1_002854 NC(=O)c1cccc(c1)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B17 compound treatment 1.11208051E8 -3.16E7 -0.4 1.11849301E8 -3.88E7 -0.66 -0.7502 -0.9697 1380307 TimTec1_002855 Nc1ncnc2[nH]c(Sc3ncnc4ccccc34)nc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B18 compound treatment 1.14439397E8 -2.84E7 -0.36 1.58447274E8 7800000.0 0.13 -0.1575 -0.4139 1630576 TimTec1_002856 Clc1cccc(c1)C(=O)NCCN2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B19 compound treatment 1.47035802E8 4190000.0 0.05 1.77447127E8 2.68E7 0.46 0.3616 0.783 3209382 TimTec1_002857 Cc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3nc(NC4CCCC4)c5ccccc5n3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B20 compound treatment 9.9006629E7 -4.38E7 -0.55 1.20329181E8 -3.03E7 -0.52 -0.7558 -0.9996 1014173 TimTec1_002858 CC(C)C(=O)Nc1cccc(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B21 compound treatment 1.24280034E8 -1.86E7 -0.23 1.46711226E8 -3930000.0 -0.07 -0.2123 -0.8757 1540718 TimTec1_002859 Cn1c2nc(c(C(=S)Nc3ccccc3)n2c4ccccc14)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B22 compound treatment 1.69854168E8 2.7E7 0.34 1.25602678E8 -2.5E7 -0.43 -0.0635 -0.1162 3084109 TimTec1_002860 C=CCN(CC=C)S(=O)(=O)Cc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B23 mock treatment 1.06389464E8 -3.65E7 -0.46 1.59532621E8 8890000.0 0.15 -0.2158 -0.4477 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 B24 mock treatment 1.64802901E8 2.2E7 0.28 1.7333758E8 2.27E7 0.39 0.4695 0.9858 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C01 compound treatment 1.53560371E8 1.07E7 0.13 1.01094153E8 -4.95E7 -0.85 -0.5047 -0.5877 3084110 TimTec1_002861 Nn1c(nnc1c2ccccn2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C02 compound treatment 6.4509612E7 -7.83E7 -0.98 7.3789914E7 -7.69E7 -1.32 -1.6251 -0.9897 3209504 TimTec1_002862 Cc1ccc(o1)c2cc(c3c(N)c(sc3n2)C(=O)c4ccc5OCOc5c4)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C03 compound treatment 1.01595354E8 -4.12E7 -0.52 7.5651277E7 -7.5E7 -1.28 -1.2736 -0.9202 1686195 TimTec1_002863 COc1ccc(CNC2CC(C)(C)NC(C)(C)C2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C04 compound treatment 9.6410083E7 -4.64E7 -0.58 7.0912908E7 -7.97E7 -1.36 -1.377 -0.9279 1012738 TimTec1_002864 COC(=O)CCC(=O)Nc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C05 compound treatment 9.7861489E7 -4.5E7 -0.56 7.5365125E7 -7.53E7 -1.29 -1.3102 -0.9314 3084183 TimTec1_002865 O=C(NCCCN1CCOCC1)NC2(CC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C06 compound treatment 1.30854671E8 -1.2E7 -0.15 1.01459376E8 -4.92E7 -0.84 -0.7017 -0.8204 1524311 TimTec1_002866 Cc1ccccc1OCC(=O)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C07 compound treatment 9.1195772E7 -5.16E7 -0.65 7.0502013E7 -8.01E7 -1.37 -1.4282 -0.9414 1120456 TimTec1_002867 COc1ccc(NC(=O)OCC23COCN3COC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C08 compound treatment 8.5474511E7 -5.74E7 -0.72 7.8903885E7 -7.17E7 -1.23 -1.3772 -0.9676 1872857 TimTec1_002868 Nc1ccc(/C=C/c2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C09 compound treatment 8.1612472E7 -6.12E7 -0.77 8.2535351E7 -6.81E7 -1.17 -1.3675 -0.9795 1455445 TimTec1_002869 CCOc1cc2CCN3C(c2cc1OCC)c4ccccc4OCC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C10 compound treatment 7.1326006E7 -7.15E7 -0.9 6.9951803E7 -8.07E7 -1.38 -1.6111 -0.9782 1520503 TimTec1_002870 S=C(NCc1ccccc1)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C11 compound treatment 7.543628E7 -6.74E7 -0.85 7.1471919E7 -7.92E7 -1.36 -1.5562 -0.9742 3084189 TimTec1_002871 Cc1sc([s+]c1SCC(=O)O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C12 compound treatment 9.2281053E7 -5.06E7 -0.63 7.8280714E7 -7.24E7 -1.24 -1.3244 -0.9517 3084190 TimTec1_002872 O=C(NCc1ccccc1)C2CCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C13 compound treatment 9.837595E7 -4.45E7 -0.56 6.2699388E7 -8.79E7 -1.51 -1.4589 -0.9087 1274042 TimTec1_002873 COCc1cc(C)nc2sc3c(=O)n(Cc4ccccc4)nnc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C14 compound treatment 9.8655926E7 -4.42E7 -0.55 8.7914536E7 -6.27E7 -1.07 -1.1512 -0.9527 1250141 TimTec1_002874 Nc1ccc(cc1)S(=O)(=O)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C15 compound treatment 9.2143296E7 -5.07E7 -0.64 6.1539192E7 -8.91E7 -1.53 -1.5283 -0.9248 1229823 TimTec1_002875 COc1ccc(cc1)S(=O)(=O)NCC2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C16 compound treatment 9.1655639E7 -5.12E7 -0.64 8.3137994E7 -6.75E7 -1.16 -1.2712 -0.9615 1379532 TimTec1_002876 O=C(Cc1ccccc1)NC2CCCCC2NC(=O)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C17 compound treatment 1.01044563E8 -4.18E7 -0.52 6.6677007E7 -8.4E7 -1.44 -1.3871 -0.9066 1324864 TimTec1_002877 CC1CCN(CNC(=O)c2cc3ccccc3o2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C18 compound treatment 9.1653737E7 -5.12E7 -0.64 7.642604E7 -7.42E7 -1.27 -1.3524 -0.95 1456811 TimTec1_002878 CC(=O)Nc1sc(Cc2ccccc2)c(C)c1C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C19 compound treatment 8.6701187E7 -5.61E7 -0.7 6.1572428E7 -8.91E7 -1.52 -1.5761 -0.9384 1430592 TimTec1_002879 COc1ccc(c2ccccc12)S(=O)(=O)N(C)CC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C20 compound treatment 9.5690304E7 -4.72E7 -0.59 8.3587525E7 -6.71E7 -1.15 -1.2299 -0.9525 1271718 TimTec1_002880 COc1ccc(OC)c(NC(=O)COc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C21 compound treatment 9.3658048E7 -4.92E7 -0.62 6.2373663E7 -8.83E7 -1.51 -1.5047 -0.9219 1255886 TimTec1_002881 CCC(CO)NC(=S)Nc1ccccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C22 compound treatment 8.9761608E7 -5.31E7 -0.67 9.0002304E7 -6.06E7 -1.04 -1.2049 -0.977 3209505 TimTec1_002882 CC1=NN(C(=S)N)C(=O)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C23 mock treatment 9.001548E7 -5.28E7 -0.66 9.3007746E7 -5.76E7 -0.99 -1.1662 -0.9813 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 C24 mock treatment 1.065493E8 -3.63E7 -0.46 9.9795821E7 -5.08E7 -0.87 -0.9374 -0.9543 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D01 compound treatment 8.1644668E7 -6.12E7 -0.77 9.2173469E7 -5.85E7 -1.0 -1.2506 -0.9914 1352115 TimTec1_002883 Fc1ccc(NC(=O)CCCC(=O)Nc2ccc(F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D02 compound treatment 7.3231812E7 -6.96E7 -0.87 8.0752065E7 -6.99E7 -1.2 -1.4635 -0.988 3084196 TimTec1_002884 CC1CCCCN1C(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D03 compound treatment 8.5491886E7 -5.74E7 -0.72 7.4100622E7 -7.65E7 -1.31 -1.4352 -0.9601 1725355 TimTec1_002885 CC(=O)Nc1ccc(cc1)S(=O)(=O)NCCC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D04 compound treatment 8.8583313E7 -5.43E7 -0.68 9.3163056E7 -5.75E7 -0.98 -1.1771 -0.9838 1463458 TimTec1_002886 CCOc1ccccc1NC(=O)c2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D05 compound treatment 7.0440468E7 -7.24E7 -0.91 8.1694695E7 -6.89E7 -1.18 -1.4768 -0.9916 3209506 TimTec1_002887 O=C(CSc1nc(c(C#N)c(=O)[nH]1)c2ccccc2)N3CCCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D06 compound treatment 8.5720489E7 -5.71E7 -0.72 9.2565647E7 -5.81E7 -0.99 -1.2097 -0.9871 1121637 TimTec1_002888 CCOc1ccc(NC(=O)c2c(OC)cccc2OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D07 compound treatment 7.4757111E7 -6.81E7 -0.85 8.7112503E7 -6.35E7 -1.09 -1.3729 -0.9929 3084200 TimTec1_002889 O=C(Nc1ccccc1C(=O)N2CCCC2)C(c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D08 compound treatment 6.5005064E7 -7.78E7 -0.98 9.067812E7 -6.0E7 -1.03 -1.4163 -0.9997 3209507 TimTec1_002890 C=CCN(CC=C)C(=O)c1cccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D09 compound treatment 7.3163517E7 -6.97E7 -0.87 8.2826071E7 -6.78E7 -1.16 -1.439 -0.9902 3084201 TimTec1_002891 Oc1ccc(Br)cc1/C=N/n2cnnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D10 compound treatment 8.3068708E7 -5.98E7 -0.75 8.8226826E7 -6.24E7 -1.07 -1.2857 -0.985 1391704 TimTec1_002892 Cc1cc(C)c(c(C)c1)S(=O)(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D11 compound treatment 9.4068084E7 -4.88E7 -0.61 9.2639825E7 -5.8E7 -0.99 -1.1347 -0.9729 3084275 TimTec1_002893 CC(C)(C)c1ccc(cc1)c2nnc(S)n2/N=C/c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D12 compound treatment 8.9508599E7 -5.33E7 -0.67 5.9898994E7 -9.07E7 -1.55 -1.5715 -0.9291 1455818 TimTec1_002894 CS(=O)(=O)N1CCN(CC1)c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D13 compound treatment 8.4883996E7 -5.8E7 -0.73 8.4145049E7 -6.65E7 -1.14 -1.319 -0.9765 1401683 TimTec1_002895 Cc1ccc(cc1)S(=O)(=O)c2c[nH]c(=O)[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D14 compound treatment 8.1057884E7 -6.18E7 -0.78 7.6040208E7 -7.46E7 -1.28 -1.4511 -0.9714 3209508 TimTec1_002896 CCN(CC)S(=O)(=O)c1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D15 compound treatment 8.7826608E7 -5.5E7 -0.69 7.8932409E7 -7.17E7 -1.23 -1.356 -0.9629 1643931 TimTec1_002897 C(Nc1nc(Nc2nc(cs2)c3ccccc3)nc(n1)N4CCCCC4)c5ccco5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D16 compound treatment 7.6975127E7 -6.59E7 -0.83 8.1877374E7 -6.88E7 -1.18 -1.4166 -0.985 3084279 TimTec1_002898 CN(Cc1ccccc1)C(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D17 compound treatment 8.6389785E7 -5.65E7 -0.71 7.9194766E7 -7.14E7 -1.22 -1.3656 -0.9662 1184589 TimTec1_002899 CCN1C(Nc2ccccc12)SCC(=O)Nc3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D18 compound treatment 9.213323E7 -5.07E7 -0.64 8.6405978E7 -6.42E7 -1.1 -1.2274 -0.9661 3084281 TimTec1_002900 CC(C)NC(=O)c1cccc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D19 compound treatment 8.3166967E7 -5.97E7 -0.75 8.8505791E7 -6.21E7 -1.06 -1.2815 -0.9852 3084282 TimTec1_002901 Clc1ccc(OCCSc2ncnc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D20 compound treatment 7.78487E7 -6.5E7 -0.82 6.9811279E7 -8.08E7 -1.38 -1.5549 -0.9682 1014159 TimTec1_002902 CC(C)C(=O)Nc1cccc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D21 compound treatment 8.6981072E7 -5.59E7 -0.7 6.4210645E7 -8.64E7 -1.48 -1.5417 -0.9417 3209509 TimTec1_002903 OC(=O)CSc1nnc(COc2ccc(Cl)cc2)n1c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D22 compound treatment 9.9153354E7 -4.37E7 -0.55 8.3627492E7 -6.7E7 -1.15 -1.1987 -0.9429 1280619 TimTec1_002904 CC1CC(C)CN(C1)S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D23 mock treatment 9.1063714E7 -5.18E7 -0.65 8.5230068E7 -6.54E7 -1.12 -1.2511 -0.9665 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 D24 mock treatment 9.8873019E7 -4.4E7 -0.55 8.6665783E7 -6.4E7 -1.1 -1.1644 -0.9496 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E01 compound treatment 1.30147774E8 -1.27E7 -0.16 1.38664223E8 -1.2E7 -0.21 -0.2576 -0.9922 1488202 TimTec1_002905 COc1ccc(CCNC2=CC(=O)OC32CCCCC3)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E02 compound treatment 1.56791241E8 1.39E7 0.17 1.71587845E8 2.09E7 0.36 0.3772 0.9456 3084286 TimTec1_002906 Cc1csc(NC(=O)c2sc3nc4CCCc4c(c3c2N)C(F)(F)F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E03 compound treatment 1.40278374E8 -2560000.0 -0.03 1.70989946E8 2.03E7 0.35 0.2235 0.6391 1319939 TimTec1_002907 CCc1ccc(cc1)C2NCCc3cc4OCCOc4cc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E04 compound treatment 1.87884176E8 4.5E7 0.57 1.67093784E8 1.64E7 0.28 0.5986 0.9483 1079846 TimTec1_002908 OC(=O)c1ccccc1C(=O)N2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E05 compound treatment 1.42787752E8 -55300.0 0.0 1.79447859E8 2.88E7 0.49 0.3482 0.7061 1117234 TimTec1_002909 OCCNC1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E06 compound treatment 1.5661323E8 1.38E7 0.17 1.32070864E8 -1.86E7 -0.32 -0.1027 -0.2837 3084289 TimTec1_002910 O=C(NCc1ccccc1)C2CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E07 compound treatment 1.51623398E8 8780000.0 0.11 1.82246008E8 3.16E7 0.54 0.4604 0.834 3209510 TimTec1_002911 COC(=O)C1=CN(CC2(CC3CC4CC(C3)C2)C4)C=C(C1c5cccs5)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E08 compound treatment 1.08913287E8 -3.39E7 -0.43 1.8475871E8 3.41E7 0.58 0.112 0.1549 1872860 TimTec1_002912 CN(CCc1ccc(C)[n+]([O-])c1)C(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E09 compound treatment 1.41911994E8 -931000.0 -0.01 1.42088914E8 -8560000.0 -0.15 -0.1118 -0.7611 1384251 TimTec1_002913 C1CN(CCO1)c2ncnc(n2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E10 compound treatment 1.90337909E8 4.75E7 0.6 1.61007898E8 1.04E7 0.18 0.5467 0.8795 1653066 TimTec1_002914 Cc1ccc(OCC(=O)Oc2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E11 compound treatment 2.01676206E8 5.88E7 0.74 1.41532779E8 -9110000.0 -0.16 0.4116 0.5456 3209511 TimTec1_002915 Cc1sc([s+]c1SCCC(=O)O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E12 compound treatment 1.6231126E8 1.95E7 0.24 1.71821957E8 2.12E7 0.36 0.429 0.9815 1739781 TimTec1_002916 Clc1ccc(OCC(=O)Oc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E13 compound treatment 1.69462098E8 2.66E7 0.33 1.36466729E8 -1.42E7 -0.24 0.0645 0.1563 1256719 TimTec1_002917 Clc1ccccc1CC2OC(=O)c3c2cc[nH]c3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E14 compound treatment 1.5087025E8 8030000.0 0.1 1.19480456E8 -3.12E7 -0.53 -0.306 -0.5637 1005147 TimTec1_002918 COc1ccc(OCC(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E15 compound treatment 1.59228298E8 1.64E7 0.21 1.58358043E8 7710000.0 0.13 0.2387 0.9771 3083277 TimTec1_002919 O=C(NCCOC1(CC2CC3CC(C2)C1)C3)c4cc5ccccc5oc4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E16 compound treatment 1.72816361E8 3.0E7 0.38 1.10438483E8 -4.02E7 -0.69 -0.2208 -0.2815 3083279 TimTec1_002920 Cc1ccc(cc1)C(=O)NCCC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E17 compound treatment 1.58950207E8 1.61E7 0.2 1.24903809E8 -2.57E7 -0.44 -0.1687 -0.348 3209512 TimTec1_002921 O=C(COc1cccc(NC(=O)c2ccccc2)c1)NCCOc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E18 compound treatment 1.48964036E8 6120000.0 0.08 1.22322975E8 -2.83E7 -0.48 -0.2885 -0.5878 1330948 TimTec1_002922 OC(=O)CCC(=O)N1CCc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E19 compound treatment 1.4556995E8 2730000.0 0.03 1.24891647E8 -2.58E7 -0.44 -0.2875 -0.6503 1780563 TimTec1_002923 OC(=O)CNC(=O)c1cc(=O)[nH]c(=O)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E20 compound treatment 1.33091489E8 -9750000.0 -0.12 2.04060879E8 5.34E7 0.91 0.5601 0.6071 1661667 TimTec1_002924 COc1ccc(CC(=O)Nc2ccc(OC)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E21 compound treatment 1.33064042E8 -9780000.0 -0.12 1.76842029E8 2.62E7 0.45 0.2304 0.4955 3083283 TimTec1_002925 COc1nsc(NN)c1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E22 compound treatment 1.98952747E8 5.61E7 0.7 1.29872956E8 -2.08E7 -0.36 0.2463 0.3123 3083284 TimTec1_002926 Cc1cc(C)n(n1)C(=O)CNc2cccc(Cl)c2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E23 mock treatment 1.63248344E8 2.04E7 0.26 1.43644422E8 -7000000.0 -0.12 0.0963 0.3406 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 E24 mock treatment 1.40740139E8 -2100000.0 -0.03 1.75642169E8 2.5E7 0.43 0.2839 0.6623 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F01 compound treatment 1.1152275E8 -3.13E7 -0.39 1.26057498E8 -2.46E7 -0.42 -0.5754 -0.9994 1189735 TimTec1_002927 CCOc1ccc(NC(=O)CCC(=O)n2nc(C)cc2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F02 compound treatment 1.16358313E8 -2.65E7 -0.33 1.36686525E8 -1.4E7 -0.24 -0.4039 -0.9869 1346484 TimTec1_002928 OCCN1CCN(CC1)S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F03 compound treatment 1.32884103E8 -9960000.0 -0.12 1.30778929E8 -1.99E7 -0.34 -0.3288 -0.9076 1244795 TimTec1_002929 O=C(Nc1ccc(cc1)S(=O)(=O)N2CCCC2)c3ccc(COc4ccc5CCCc5c4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F04 compound treatment 1.15072036E8 -2.78E7 -0.35 1.38786015E8 -1.19E7 -0.2 -0.3899 -0.9669 3083288 TimTec1_002930 Brc1ccc(cc1)C(=O)NCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F05 compound treatment 1.1966032E8 -2.32E7 -0.29 1.38404909E8 -1.22E7 -0.21 -0.3538 -0.9871 1551713 TimTec1_002931 CC1=NN(C(=O)C1)c2ccc(cc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F06 compound treatment 1.24423627E8 -1.84E7 -0.23 1.32482505E8 -1.82E7 -0.31 -0.3832 -0.9893 1278318 TimTec1_002932 Cc1cccc(NC(=O)c2cccnc2)c1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F07 compound treatment 1.56267412E8 1.34E7 0.17 1.54569811E8 3930000.0 0.07 0.1666 0.9188 3209639 TimTec1_002933 COc1ccc(NC(=O)n2ccc(n2)C(=O)N3CCOCC3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F08 compound treatment 1.10528665E8 -3.23E7 -0.41 1.4474213E8 -5900000.0 -0.1 -0.3581 -0.8571 3083290 TimTec1_002934 CC1CC(C)CN(C1)C(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F09 compound treatment 1.19974603E8 -2.29E7 -0.29 1.92051812E8 4.14E7 0.71 0.2984 0.3902 3209640 TimTec1_002935 C/C(=C\c1ccco1)/C=N/N2CCN(CC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F10 compound treatment 1.25173771E8 -1.77E7 -0.22 1.26085041E8 -2.46E7 -0.42 -0.454 -0.9553 3083291 TimTec1_002936 CC(C)CNS(=O)(=O)c1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F11 compound treatment 1.21930928E8 -2.09E7 -0.26 1.3769616E8 -1.29E7 -0.22 -0.3422 -0.9965 3209641 TimTec1_002937 Sc1nnc(c2cccnc2)n1/N=C/C=C/c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F12 compound treatment 1.28092262E8 -1.48E7 -0.19 1.36745244E8 -1.39E7 -0.24 -0.2991 -0.9923 3083293 TimTec1_002938 CC(C)NC(=O)c1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F13 compound treatment 1.25806946E8 -1.7E7 -0.21 1.6664032E8 1.6E7 0.27 0.0425 0.1224 1394669 TimTec1_002939 OC(=O)COc1ccc(NS(=O)(=O)c2cccc3nsnc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F14 compound treatment 1.10217253E8 -3.26E7 -0.41 1.59216825E8 8570000.0 0.15 -0.1856 -0.427 1007338 TimTec1_002940 CS(=O)(=O)NC(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F15 compound treatment 1.02273384E8 -4.06E7 -0.51 1.19846505E8 -3.08E7 -0.53 -0.7326 -0.9998 1623851 TimTec1_002941 CN1CCC2C(C1)c3cc(C)ccc3N2C(=O)Cn4nnc(n4)c5ccccc5C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F16 compound treatment 1.73268891E8 3.04E7 0.38 1.71427583E8 2.08E7 0.36 0.5215 0.9994 3083330 TimTec1_002942 CCC1CCCCN1S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F17 compound treatment 1.17858781E8 -2.5E7 -0.31 7.7623211E7 -7.3E7 -1.25 -1.1055 -0.8579 3209642 TimTec1_002943 O=C(Cn1cc(/C=C\2/C(=O)NC(=O)N(Cc3ccco3)C2=O)c4ccccc14)NCC5CCCO5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F18 compound treatment 1.60837097E8 1.8E7 0.23 8.612129E7 -6.45E7 -1.1 -0.6214 -0.5512 1208206 TimTec1_002944 Fc1ccc(cc1)C(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F19 compound treatment 1.38361578E8 -4480000.0 -0.06 1.14842538E8 -3.58E7 -0.61 -0.4731 -0.7687 3083297 TimTec1_002945 COc1ccc(cc1)/C(=C/C2=NC(C)(C)CO2)/N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F20 compound treatment 1.50758103E8 7920000.0 0.1 1.28284264E8 -2.24E7 -0.38 -0.2004 -0.5069 3209643 TimTec1_002946 COC(=O)c1ccc(NC(=O)C(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F21 compound treatment 1.17940188E8 -2.49E7 -0.31 1.16007305E8 -3.46E7 -0.59 -0.6401 -0.9552 1165003 TimTec1_002947 CC1=C(C)CC(C(C1)C(=O)O)C(=O)Nc2ccc3c(c2)oc4ccccc43 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F22 compound treatment 1.13649174E8 -2.92E7 -0.37 1.74341412E8 2.37E7 0.41 0.0279 0.051 1151238 TimTec1_002948 O=S(=O)(Cc1ccccc1)N2CCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F23 mock treatment 1.29570189E8 -1.33E7 -0.17 1.29526458E8 -2.11E7 -0.36 -0.3733 -0.9381 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 F24 mock treatment 1.32514054E8 -1.03E7 -0.13 1.66401636E8 1.58E7 0.27 0.0991 0.3312 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G01 compound treatment 1.61937722E8 1.91E7 0.24 1.4959929E8 -1040000.0 -0.02 0.1567 0.6525 1275078 TimTec1_002949 CCOC(=O)C1CCN(CC1)S(=O)(=O)c2nc3nc(C)cc(C)n3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G02 compound treatment 1.53778561E8 1.09E7 0.14 1.29503654E8 -2.11E7 -0.36 -0.1589 -0.4105 3209644 TimTec1_002950 CCCCc1[nH]nc2OC(=C(C#N)C3(CCCCC3)c12)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G03 compound treatment 1.88446071E8 4.56E7 0.57 1.09426602E8 -4.12E7 -0.71 -0.0944 -0.1039 1154081 TimTec1_002951 COC(=O)Nc1c(Cl)nsc1S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G04 compound treatment 1.15775764E8 -2.71E7 -0.34 1.06308788E8 -4.43E7 -0.76 -0.7767 -0.9342 1466731 TimTec1_002952 Cc1ccc(OC(=O)CCC(=O)Nc2cccc(C#N)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G05 compound treatment 1.51341802E8 8500000.0 0.11 1.24822687E8 -2.58E7 -0.44 -0.2372 -0.5216 1082369 TimTec1_002953 NCCNC1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G06 compound treatment 1.22440956E8 -2.04E7 -0.26 1.30228867E8 -2.04E7 -0.35 -0.4281 -0.9883 3209645 TimTec1_002954 NC(=O)c1ccccc1NC(=O)CCCOc2ccc(Cl)cc2Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G07 compound treatment 1.28114891E8 -1.47E7 -0.18 1.16536459E8 -3.41E7 -0.58 -0.5435 -0.8875 1419997 TimTec1_002955 Fc1ccc(OCC(=O)n2cnc3ccccc23)c(F)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G08 compound treatment 1.32799064E8 -1.0E7 -0.13 1.14680237E8 -3.6E7 -0.62 -0.5244 -0.8345 1305850 TimTec1_002956 CC(NC(=O)c1ccncc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G09 compound treatment 1.43367175E8 524000.0 0.01 1.08429154E8 -4.22E7 -0.72 -0.5063 -0.7006 1253485 TimTec1_002957 O=C(Nc1ccccc1)c2scc3CCCCc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G10 compound treatment 1.32398796E8 -1.04E7 -0.13 1.11163327E8 -3.95E7 -0.68 -0.5705 -0.8288 1154113 TimTec1_002958 COC(=O)C1CNCCN1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G11 compound treatment 1.24076851E8 -1.88E7 -0.24 9.8271736E7 -5.24E7 -0.9 -0.8004 -0.8635 1479855 TimTec1_002959 Nc1cc(O)nc(SCC(=O)NC2CCCCC2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G12 compound treatment 1.1796831E8 -2.49E7 -0.31 1.1280473E8 -3.78E7 -0.65 -0.6787 -0.9439 3083867 TimTec1_002960 CC1CCN(CC1)S(=O)(=O)c2ccc(/N=C/3\C(=O)Nc4ccccc34)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G13 compound treatment 1.08024552E8 -3.48E7 -0.44 1.14045785E8 -3.66E7 -0.63 -0.7518 -0.9845 1231567 TimTec1_002961 O=C1Nc2ccccc2C1C3Sc4ccccc4NC3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G14 compound treatment 8.8232082E7 -5.46E7 -0.69 6.2371481E7 -8.83E7 -1.51 -1.5529 -0.936 3083940 TimTec1_002962 O=c1ccn([nH]1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G15 compound treatment 1.50455019E8 7610000.0 0.1 1.45387063E8 -5260000.0 -0.09 0.0039 0.0296 3083942 TimTec1_002963 COC(=O)c1ccc2CCc3cccc1c32 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G16 compound treatment 1.15430491E8 -2.74E7 -0.34 1.23708919E8 -2.69E7 -0.46 -0.5692 -0.9896 3083945 TimTec1_002964 Clc1ccc(cc1)C(=O)NCCC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G17 compound treatment 1.16208747E8 -2.66E7 -0.33 1.24283829E8 -2.64E7 -0.45 -0.5553 -0.9891 3083946 TimTec1_002965 Cc1ccc(cc1)S(=O)(=O)NCCSc2nnnn2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G18 compound treatment 1.42500752E8 -342000.0 0.0 1.42842182E8 -7800000.0 -0.13 -0.0975 -0.7295 3209646 TimTec1_002966 CC1=NN(C(=S)N)C(=O)C1C(C(C#N)C#N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G19 compound treatment 1.05622116E8 -3.72E7 -0.47 1.47052351E8 -3590000.0 -0.06 -0.3736 -0.7934 1312727 TimTec1_002967 COc1ccccc1C(CC(=O)N2CCCC2)c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G20 compound treatment 1.23837637E8 -1.9E7 -0.24 1.14274085E8 -3.64E7 -0.62 -0.6088 -0.9132 1605427 TimTec1_002968 Cc1ccccc1NC(=O)CCC(=O)Nc2ccccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G21 compound treatment 1.62231494E8 1.94E7 0.24 1.13569422E8 -3.71E7 -0.63 -0.2768 -0.4072 3209647 TimTec1_002969 CCC1CCc2nc3sc(C(=O)NCCc4ccc(OC)cc4)c(N)c3cc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G22 compound treatment 1.29213437E8 -1.36E7 -0.17 1.27137743E8 -2.35E7 -0.4 -0.4054 -0.9273 1624978 TimTec1_002970 O=C(Nc1ccccc1)Nc2ccc(Nc3ccccc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G23 mock treatment 1.17690383E8 -2.52E7 -0.32 1.33286412E8 -1.74E7 -0.3 -0.4332 -0.9995 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 G24 mock treatment 1.29298612E8 -1.35E7 -0.17 1.5391091E8 3270000.0 0.06 -0.0806 -0.4506 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H01 compound treatment 1.02095855E8 -4.07E7 -0.51 1.15918726E8 -3.47E7 -0.59 -0.7818 -0.9972 1612290 TimTec1_002971 O=C(CCCC(=O)N1CCCc2ccccc12)N3CCCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H02 compound treatment 1.25602715E8 -1.72E7 -0.22 1.40087349E8 -1.06E7 -0.18 -0.2807 -0.996 1583605 TimTec1_002972 CC1CCCCN1S(=O)(=O)c2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H03 compound treatment 1.34304072E8 -8540000.0 -0.11 1.21927462E8 -2.87E7 -0.49 -0.4233 -0.8414 3209648 TimTec1_002973 NC(=O)c1ccccc1NC(=O)c2cccc(COc3ccc4CCCc4c3)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H04 compound treatment 1.39996492E8 -2850000.0 -0.04 1.18208409E8 -3.24E7 -0.56 -0.4179 -0.751 1192634 TimTec1_002974 CCOc1ccccc1NC(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H05 compound treatment 1.01639064E8 -4.12E7 -0.52 1.15132531E8 -3.55E7 -0.61 -0.7953 -0.9967 1045732 TimTec1_002975 O=P(c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H06 compound treatment 1.27235057E8 -1.56E7 -0.2 1.39470364E8 -1.12E7 -0.19 -0.2737 -0.9999 1524458 TimTec1_002976 CCN(Cc1ccccc1)C(=O)c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H07 compound treatment 1.13973529E8 -2.89E7 -0.36 1.16974891E8 -3.37E7 -0.58 -0.6636 -0.9749 3209649 TimTec1_002977 Clc1ccc(NC(=O)c2cc[nH]n2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H08 compound treatment 1.04145266E8 -3.87E7 -0.49 1.34152204E8 -1.65E7 -0.28 -0.5429 -0.9667 1548424 TimTec1_002978 OCCN(Cc1ccccc1)S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H09 compound treatment 1.37460621E8 -5380000.0 -0.07 1.08150354E8 -4.25E7 -0.73 -0.5621 -0.7694 3209650 TimTec1_002979 C(N1CCN(CC1)/N=C/c2ccco2)c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H10 compound treatment 9.6925824E7 -4.59E7 -0.58 1.26488714E8 -2.42E7 -0.41 -0.6997 -0.9868 3083954 TimTec1_002980 Clc1ccc(Cl)c(c1)S(=O)(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H11 compound treatment 1.05770098E8 -3.71E7 -0.47 9.6562473E7 -5.41E7 -0.93 -0.9835 -0.9493 3209651 TimTec1_002981 Sc1nnc(C2CCCCC2)n1/N=C\c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H12 compound treatment 1.12906912E8 -2.99E7 -0.38 1.18780661E8 -3.19E7 -0.55 -0.6512 -0.9834 3209652 TimTec1_002982 CCCN(CCC)C(=O)c1ccccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H13 compound treatment 1.04819534E8 -3.8E7 -0.48 1.07534642E8 -4.31E7 -0.74 -0.8591 -0.9777 3083957 TimTec1_002983 Fc1ccc(cc1)c2csc(n2)N3CCN(C/C=C\c4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H14 compound treatment 9.9181072E7 -4.37E7 -0.55 1.06005495E8 -4.46E7 -0.76 -0.9276 -0.9867 1721421 TimTec1_002984 CCC1CCCCN1C(=O)c2ccc(OC)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H15 compound treatment 1.00084351E8 -4.28E7 -0.54 1.46682677E8 -3960000.0 -0.07 -0.4272 -0.7902 1628659 TimTec1_002985 CC(=O)N(CCc1c(C)[nH]c2ccccc12)C(C(=O)Nc3c(C)cccc3C)c4ccc(Cl)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H16 compound treatment 1.73592031E8 3.07E7 0.39 1.10168253E8 -4.05E7 -0.69 -0.2172 -0.2739 1214933 TimTec1_002986 Cc1cc(C)c(c(C)c1)S(=O)(=O)N2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H17 compound treatment 1.03430857E8 -3.94E7 -0.49 9.1471891E7 -5.92E7 -1.01 -1.0658 -0.9456 3209772 TimTec1_002987 Cc1cc(ccc1Br)c2ccc(/C=C\3/C(=O)NC(=O)N(C4CCCCC4)C3=O)o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H18 compound treatment 1.07264675E8 -3.56E7 -0.45 9.9368092E7 -5.13E7 -0.88 -0.9362 -0.9508 3084027 TimTec1_002988 CC(C)NC(=O)c1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H19 compound treatment 9.728911E7 -4.56E7 -0.57 1.06511896E8 -4.41E7 -0.76 -0.9383 -0.9905 1265488 TimTec1_002989 Clc1ccc(CN(CC(=O)N2CCCC2)S(=O)(=O)c3ccccc3)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H20 compound treatment 1.37834158E8 -5010000.0 -0.06 1.17557089E8 -3.31E7 -0.57 -0.4449 -0.7808 3084032 TimTec1_002990 CC(C)C(=O)Nc1nc2ccccc2s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H21 compound treatment 1.0549497E8 -3.73E7 -0.47 1.24581103E8 -2.61E7 -0.45 -0.6468 -0.9997 1077722 TimTec1_002991 Cc1ccc(cc1)S(=O)(=O)NCC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H22 compound treatment 1.09724369E8 -3.31E7 -0.42 1.5408868E8 3440000.0 0.06 -0.2521 -0.6007 1060751 TimTec1_002992 O=S(=O)(Cc1ccccc1)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H23 mock treatment 1.14277752E8 -2.86E7 -0.36 1.70504065E8 1.99E7 0.34 -0.013 -0.0263 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 H24 mock treatment 1.12097521E8 -3.07E7 -0.39 1.74336687E8 2.37E7 0.41 0.0141 0.0251 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I01 compound treatment 1.70811002E8 2.8E7 0.35 1.77537242E8 2.69E7 0.46 0.5736 0.991 1532792 TimTec1_002993 CC(C)CCN1NC(C)(C)NC1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I02 compound treatment 1.57127774E8 1.43E7 0.18 1.88574616E8 3.79E7 0.65 0.5858 0.8697 3209773 TimTec1_002994 Clc1ccc(OCCCC(=O)Nc2nccs2)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I03 compound treatment 1.71444957E8 2.86E7 0.36 1.84336344E8 3.37E7 0.58 0.6615 0.9739 1336661 TimTec1_002995 CC1(C)CC(CC(C)(C)N1)NC2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I04 compound treatment 1.77779941E8 3.49E7 0.44 2.00825279E8 5.02E7 0.86 0.9173 0.9512 1482766 TimTec1_002996 Cc1cccc(OCC(=O)Nc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I05 compound treatment 1.99849704E8 5.7E7 0.72 2.15621535E8 6.5E7 1.11 1.2922 0.9772 1626149 TimTec1_002997 Cc1[nH]c2ccccc2c1CCN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I06 compound treatment 1.81219389E8 3.84E7 0.48 1.96274344E8 4.56E7 0.78 0.8927 0.973 3209774 TimTec1_002998 COC(=O)c1ccc(OC)c(Br)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I07 compound treatment 1.67676234E8 2.48E7 0.31 2.07789548E8 5.71E7 0.98 0.912 0.8883 1162114 TimTec1_002999 COc1ccc(cc1)C(NC(=O)C2CC=CCC2C(=O)O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I08 compound treatment 1.76485109E8 3.36E7 0.42 2.2545027E8 7.48E7 1.28 1.2039 0.8929 1581961 TimTec1_003000 OC(=O)CCC(=O)c1c[nH]c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I09 compound treatment 1.83763424E8 4.09E7 0.51 2.04519193E8 5.39E7 0.92 1.0151 0.9617 3209775 TimTec1_003001 Cc1[nH]c2cc3c(cc(=O)[nH]c3cc2c1C)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I10 compound treatment 2.01307262E8 5.85E7 0.73 2.17836384E8 6.72E7 1.15 1.3319 0.9764 1329961 TimTec1_003002 OC(=O)C1C(C2CC1C=C2)C(=O)OCC3CCCO3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I11 compound treatment 1.82052719E8 3.92E7 0.49 1.87203567E8 3.66E7 0.63 0.7903 0.9929 3209776 TimTec1_003003 Sc1nnnn1C2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I12 compound treatment 1.95433466E8 5.26E7 0.66 1.82207413E8 3.16E7 0.54 0.8485 0.9951 1562475 TimTec1_003004 O=C(CCCC(=O)Nc1ccccc1C#N)Nc2ccccc2C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I13 compound treatment 2.13991362E8 7.11E7 0.89 1.90462113E8 3.98E7 0.68 1.1131 0.9911 3084037 TimTec1_003005 CCSc1nnc(C)c(O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I14 compound treatment 2.07189476E8 6.43E7 0.81 1.84009609E8 3.34E7 0.57 0.9746 0.9857 1850983 TimTec1_003006 O=C(Cc1cccc2ccccc12)Nc3ccc(cc3)S(=O)(=O)N4CCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I15 compound treatment 1.88638084E8 4.58E7 0.57 1.7940498E8 2.88E7 0.49 0.7543 0.997 1481588 TimTec1_003007 O=C(NCN1CCCCC1)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I16 compound treatment 1.98946304E8 5.61E7 0.7 2.08300279E8 5.77E7 0.99 1.1955 0.9863 3084039 TimTec1_003008 Clc1ccc(NC(=O)NCC=C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I17 compound treatment 1.78498953E8 3.57E7 0.45 1.51052769E8 409000.0 0.01 0.3212 0.7181 3209777 TimTec1_003009 CCOC(=O)/C(=N/O)/C1=NC2(C)CCCCC2c3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I18 compound treatment 1.75746472E8 3.29E7 0.41 1.99123448E8 4.85E7 0.83 0.8787 0.948 1346661 TimTec1_003010 NC(=O)CSc1nc2CCCCc2cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I19 compound treatment 2.07053131E8 6.42E7 0.81 1.6937344E8 1.87E7 0.32 0.7963 0.9185 3209778 TimTec1_003011 CC1(C)Cc2c(cnn2c3ccc(F)cc3)-c4nc5ccccc5nc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I20 compound treatment 1.77155186E8 3.43E7 0.43 1.77704601E8 2.71E7 0.46 0.6319 0.9993 3209779 TimTec1_003012 O=C1C2CC=CCC2C(=O)N1c3cccc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I21 compound treatment 1.81603683E8 3.88E7 0.49 1.56267044E8 5620000.0 0.1 0.4119 0.831 3084043 TimTec1_003013 CSc1nc(cc(c1C#N)C(F)(F)F)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I22 compound treatment 1.8499423E8 4.22E7 0.53 1.5872065E8 8080000.0 0.14 0.4717 0.863 1352505 TimTec1_003014 NC(=O)c1c(NC(=O)Nc2ccccc2)sc3CCCCc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I23 mock treatment 1.73681772E8 3.08E7 0.39 1.65831442E8 1.52E7 0.26 0.4574 0.9813 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 I24 mock treatment 2.13985775E8 7.11E7 0.89 1.71737514E8 2.11E7 0.36 0.8864 0.9207 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J01 compound treatment 1.74589765E8 3.17E7 0.4 1.66521567E8 1.59E7 0.27 0.4738 0.9827 1181166 TimTec1_003015 Cc1cc(C)cc(NC(=O)CCCC(=O)Nc2cc(C)cc(C)c2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J02 compound treatment 1.37855532E8 -4990000.0 -0.06 1.41961609E8 -8680000.0 -0.15 -0.1493 -0.9261 3209780 TimTec1_003016 COc1ccc(cc1)S(=O)(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J03 compound treatment 1.60217826E8 1.74E7 0.22 1.55728573E8 5080000.0 0.09 0.2157 0.9189 3209781 TimTec1_003017 COC(=O)c1c(NC(=O)C2CC2c3ccccc3)scc1c4ccc(OC)c(OC)c4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J04 compound treatment 1.88808107E8 4.6E7 0.58 1.68417831E8 1.78E7 0.3 0.6229 0.9554 3084046 TimTec1_003018 CC1CC(C)CN(C1)C(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J05 compound treatment 1.82796404E8 4.0E7 0.5 1.77326454E8 2.67E7 0.46 0.6774 0.9989 1016006 TimTec1_003019 C(Cc1ccccc1)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J06 compound treatment 1.71800294E8 2.9E7 0.36 1.95640872E8 4.5E7 0.77 0.8015 0.9412 1618846 TimTec1_003020 O=C(N(CC#N)CC#N)c1cccc(c1)C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J07 compound treatment 1.84829898E8 4.2E7 0.53 1.73621647E8 2.3E7 0.39 0.6506 0.9897 1010630 TimTec1_003021 NC(=N)Nc1nc2ccccc2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J08 compound treatment 1.79260795E8 3.64E7 0.46 1.77536519E8 2.69E7 0.46 0.6486 1.0 3084116 TimTec1_003022 CC1CCCN(C1)S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J09 compound treatment 1.71538221E8 2.87E7 0.36 1.90442064E8 3.98E7 0.68 0.7363 0.9555 3209782 TimTec1_003023 C1CN(CCN1N=Cc2cccs2)C3c4ccccc4-c5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J10 compound treatment 1.78656111E8 3.58E7 0.45 1.36186257E8 -1.45E7 -0.25 0.1427 0.2782 3084118 TimTec1_003024 Clc1ccc(Cl)c(c1)S(=O)(=O)NCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J11 compound treatment 1.77001285E8 3.42E7 0.43 1.82508308E8 3.19E7 0.55 0.6887 0.9929 3209783 TimTec1_003025 Cn1cccc1/C=N/n2c(S)nnc2COc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J12 compound treatment 1.36291768E8 -6550000.0 -0.08 1.52594097E8 1950000.0 0.03 -0.0345 -0.389 1268911 TimTec1_003026 CCN(CC)C(=O)c1cccc(c1)C(=O)N(CC)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J13 compound treatment 1.31078746E8 -1.18E7 -0.15 1.89023222E8 3.84E7 0.66 0.3602 0.5349 1161626 TimTec1_003027 CN(C(=O)CSc1nc2ccccc2o1)C3(CCCCC3)C(=O)Nc4c(C)cccc4C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J14 compound treatment 1.67902621E8 2.51E7 0.31 1.53528858E8 2880000.0 0.05 0.2572 0.8083 1594441 TimTec1_003028 O=C(Cc1ccccc1)NCc2ccncc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J15 compound treatment 1.67268522E8 2.44E7 0.31 1.85503728E8 3.49E7 0.6 0.6386 0.952 1323967 TimTec1_003029 CCOC(=O)c1c(C)n(c2ccccc2)c3ccc4OCN(Cc5ccccc5)Cc4c13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J16 compound treatment 1.69427765E8 2.66E7 0.33 1.77941473E8 2.73E7 0.47 0.5662 0.9863 1294833 TimTec1_003030 Cc1cc(C)c(c(C)c1)S(=O)(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J17 compound treatment 1.74148953E8 3.13E7 0.39 1.71185202E8 2.05E7 0.35 0.5263 0.9985 3209784 TimTec1_003031 Cc1ccc(OCCCn2cc(/C=C\3/C(=O)NC(=O)N(C4CCCCC4)C3=O)c5ccccc25)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J18 compound treatment 1.57822471E8 1.5E7 0.19 1.75219791E8 2.46E7 0.42 0.4303 0.934 3084123 TimTec1_003032 CCC1CCCCN1C(=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J19 compound treatment 1.88382542E8 4.55E7 0.57 1.78674406E8 2.8E7 0.48 0.7432 0.9962 3209785 TimTec1_003033 Cc1cccc(C)c1NCc2nnc(S)n2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J20 compound treatment 1.57090565E8 1.42E7 0.18 1.79702162E8 2.91E7 0.5 0.4781 0.9046 3084125 TimTec1_003034 CC(C)C(=O)N1CC(C)OC(C)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J21 compound treatment 1.76008503E8 3.32E7 0.42 1.41219749E8 -9420000.0 -0.16 0.1801 0.4036 3209786 TimTec1_003035 O=C(NCCCN1CCOCC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J22 compound treatment 1.51898549E8 9060000.0 0.11 1.87003953E8 3.64E7 0.62 0.5204 0.8226 1472519 TimTec1_003036 O=S(=O)(Cc1ccccc1)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J23 mock treatment 1.77673495E8 3.48E7 0.44 1.73019092E8 2.24E7 0.38 0.5798 0.9978 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 J24 mock treatment 1.71791495E8 2.89E7 0.36 1.78902573E8 2.83E7 0.48 0.5988 0.99 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K01 compound treatment 1.30962336E8 -1.19E7 -0.15 1.10843114E8 -3.98E7 -0.68 -0.5871 -0.8419 3209787 TimTec1_003037 Cc1[nH]c2ccc(OC(F)(F)F)cc2c1CCNC(=O)c3c(Cl)cnn3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K02 compound treatment 1.7775164E8 3.49E7 0.44 1.58788236E8 8140000.0 0.14 0.4082 0.8883 1741001 TimTec1_003038 CC(=O)NS(=O)(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K03 compound treatment 1.45166481E8 2320000.0 0.03 1.11072237E8 -3.96E7 -0.68 -0.4584 -0.6761 1674832 TimTec1_003039 Cc1ccc2c3C(C4CCC=CC4)C5=C(CCCC5=O)Nc3ccc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K04 compound treatment 1.70546294E8 2.77E7 0.35 1.89546024E8 3.89E7 0.67 0.7166 0.954 1039966 TimTec1_003040 Cc1cc(Br)ccc1OCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K05 compound treatment 1.54203062E8 1.14E7 0.14 1.57857719E8 7210000.0 0.12 0.1881 0.9975 3084130 TimTec1_003041 C=CCNC(=O)c1scc2CCCCc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K06 compound treatment 1.6463689E8 2.18E7 0.27 1.13160706E8 -3.75E7 -0.64 -0.2604 -0.3733 1150301 TimTec1_003042 COC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2cc(C)cc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K07 compound treatment 1.47575519E8 4730000.0 0.06 1.52949034E8 2310000.0 0.04 0.0699 0.9803 3084131 TimTec1_003043 FC(F)(F)C(=C(C#N)C#N)NC1(CC2CC3CC(C2)C1)C3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K08 compound treatment 1.53818152E8 1.1E7 0.14 1.48406245E8 -2240000.0 -0.04 0.0703 0.4917 1711851 TimTec1_003044 OC(=O)CCCC(=O)c1c[nH]c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K09 compound treatment 1.53447634E8 1.06E7 0.13 1.07007958E8 -4.36E7 -0.75 -0.4341 -0.5722 1235296 TimTec1_003045 COC(=O)c1cc(=O)c2c(C)nc(nc2[nH]1)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K10 compound treatment 1.27496643E8 -1.53E7 -0.19 1.33233573E8 -1.74E7 -0.3 -0.3469 -0.9776 1402776 TimTec1_003046 COc1ccc(cc1)N2C(=O)C3CC=CCC3C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K11 compound treatment 1.43828914E8 986000.0 0.01 1.97349076E8 4.67E7 0.8 0.5741 0.718 3084204 TimTec1_003047 COc1ccccc1C(=O)NCCOc2ccc(C)c(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K12 compound treatment 1.3391543E8 -8930000.0 -0.11 1.29764135E8 -2.09E7 -0.36 -0.3319 -0.8862 1478099 TimTec1_003048 O=C(CCCC(=O)Nc1cccc(C#N)c1)Nc2cccc(C#N)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K13 compound treatment 1.74279269E8 3.14E7 0.39 1.70611596E8 2.0E7 0.34 0.5205 0.9975 1420277 TimTec1_003049 CCOc1nc(NCCC2=CCCCC2)nc(OCC)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K14 compound treatment 1.76390746E8 3.35E7 0.42 1.32626318E8 -1.8E7 -0.31 0.0795 0.1523 3209907 TimTec1_003050 OC(=O)[C@H]1CCCC[C@H]1C(=O)N[C@H]2CCCC[C@@H]2NC(=O)[C@H]3CCCC[C@H]3C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K15 compound treatment 1.29190258E8 -1.37E7 -0.17 1.01021611E8 -4.96E7 -0.85 -0.7217 -0.8329 1327396 TimTec1_003051 Oc1nc2ccccc2nc1C(=S)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K16 compound treatment 2.12397009E8 6.96E7 0.87 1.37380188E8 -1.33E7 -0.23 0.4564 0.5062 1197923 TimTec1_003052 Cc1cc(C)cc(NC(=O)c2ccccc2C(=O)O)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K17 compound treatment 1.65433032E8 2.26E7 0.28 1.46565325E8 -4080000.0 -0.07 0.151 0.5174 1529000 TimTec1_003053 CC1CCN(CC1)S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K18 compound treatment 1.69086919E8 2.62E7 0.33 1.50381328E8 -263000.0 0.0 0.2296 0.6974 1041191 TimTec1_003054 NCCc1nc2ccccc2[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K19 compound treatment 1.26869273E8 -1.6E7 -0.2 1.16424823E8 -3.42E7 -0.59 -0.5559 -0.8979 1201759 TimTec1_003055 Cc1nc2cccc(C(=O)O)c2o1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K20 compound treatment 1.20723754E8 -2.21E7 -0.28 1.2959923E8 -2.1E7 -0.36 -0.4509 -0.9917 1725455 TimTec1_003056 OC(=O)CSc1nc2CCCc2cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K21 compound treatment 1.26241995E8 -1.66E7 -0.21 1.52509283E8 1870000.0 0.03 -0.1247 -0.5918 3209908 TimTec1_003057 Cc1ccc(cc1)S(=O)(=O)CCSc2nc(cc(c2C#N)C(F)(F)F)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K22 compound treatment 1.9271091E8 4.99E7 0.63 1.12541794E8 -3.81E7 -0.65 -0.0189 -0.0209 1144928 TimTec1_003058 OC(=O)c1ccccc1C(=O)NCC2CCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K23 mock treatment 1.20883892E8 -2.2E7 -0.28 1.32423013E8 -1.82E7 -0.31 -0.4153 -0.9981 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 K24 mock treatment 1.64281301E8 2.14E7 0.27 1.89418109E8 3.88E7 0.66 0.6595 0.9209 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L01 compound treatment 1.20600054E8 -2.22E7 -0.28 1.29024781E8 -2.16E7 -0.37 -0.459 -0.9903 1440528 TimTec1_003059 CCN(CC)C(=O)COc1ccc2ccccc2c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L02 compound treatment 1.22036636E8 -2.08E7 -0.26 1.28284582E8 -2.24E7 -0.38 -0.4552 -0.9826 1517728 TimTec1_003060 CS(=O)(=O)N(Cc1ccccc1)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L03 compound treatment 1.18842195E8 -2.4E7 -0.3 1.47103326E8 -3540000.0 -0.06 -0.2558 -0.8327 3209909 TimTec1_003061 Cc1nn(Cc2cccc3ccccc23)c(C)c1NC(=O)C4CC4c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L04 compound treatment 1.17768434E8 -2.51E7 -0.31 1.34153551E8 -1.65E7 -0.28 -0.422 -0.9985 3084214 TimTec1_003062 CCCNC(=O)c1ccccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L05 compound treatment 1.21992754E8 -2.09E7 -0.26 1.21822638E8 -2.88E7 -0.49 -0.5338 -0.9559 1514538 TimTec1_003063 O=C1OC(C2OC(=O)c3ccccc23)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L06 compound treatment 1.29700513E8 -1.31E7 -0.16 1.23775855E8 -2.69E7 -0.46 -0.4418 -0.9042 3084215 TimTec1_003064 FC(F)(F)c1ccccc1NC(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L07 compound treatment 1.60366292E8 1.75E7 0.22 1.18797511E8 -3.18E7 -0.55 -0.23 -0.3914 3209910 TimTec1_003065 CC(=C)CSc1nnc(SCc2cccc3ccccc23)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L08 compound treatment 1.46913658E8 4070000.0 0.05 1.21781453E8 -2.89E7 -0.49 -0.3133 -0.6307 1626374 TimTec1_003066 O=S(=O)(N(Cc1ccccc1)c2ccccn2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L09 compound treatment 1.1549654E8 -2.73E7 -0.34 1.1938742E8 -3.13E7 -0.54 -0.6209 -0.9769 3084216 TimTec1_003067 Cn1cccc1C=NN2CCN(CC2)C3c4ccccc4-c5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L10 compound treatment 1.20691283E8 -2.22E7 -0.28 1.18521776E8 -3.21E7 -0.55 -0.5853 -0.95 3209911 TimTec1_003068 Clc1ccc(Cl)c(c1)S(=O)(=O)NCCCn2ccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L11 compound treatment 1.24508922E8 -1.83E7 -0.23 1.45038033E8 -5610000.0 -0.1 -0.2305 -0.9249 1381409 TimTec1_003069 O=C(Nc1cccc(OC(=O)c2cccc(c2)S(=O)(=O)N3CCOCC3)c1)c4cccs4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L12 compound treatment 1.56142463E8 1.33E7 0.17 1.18255745E8 -3.24E7 -0.55 -0.2741 -0.4734 3084218 TimTec1_003070 CCN(CC)S(=O)(=O)c1ccc(OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L13 compound treatment 1.125163E8 -3.03E7 -0.38 1.02719255E8 -4.79E7 -0.82 -0.8491 -0.939 1122440 TimTec1_003071 Clc1ccc(C(=O)n2c(=O)oc3cc(ccc23)S(=O)(=O)N4CCCCC4)c(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L14 compound treatment 1.32274194E8 -1.06E7 -0.13 1.23805242E8 -2.68E7 -0.46 -0.4186 -0.8754 3209912 TimTec1_003072 O=C(Cc1ccccc1)N2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L15 compound treatment 1.34021247E8 -8820000.0 -0.11 1.12916929E8 -3.77E7 -0.65 -0.5349 -0.8164 3209913 TimTec1_003073 CC(C)c1ccc(cc1)S(=O)(=O)NCCOC2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L16 compound treatment 1.15884265E8 -2.7E7 -0.34 1.11042625E8 -3.96E7 -0.68 -0.7185 -0.9484 1425735 TimTec1_003074 CS(=O)(=O)N1CCC(Cc2ccccc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L17 compound treatment 1.16081388E8 -2.68E7 -0.34 1.34180889E8 -1.65E7 -0.28 -0.4367 -0.9962 3209914 TimTec1_003075 O=C(Nc1ccc(cc1)N2CCCC2)/C=C/c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L18 compound treatment 1.14953971E8 -2.79E7 -0.35 1.19599012E8 -3.1E7 -0.53 -0.6232 -0.9794 3084222 TimTec1_003076 CC(C)C(=O)Nc1ccccc1C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L19 compound treatment 1.24625959E8 -1.82E7 -0.23 1.24962027E8 -2.57E7 -0.44 -0.4725 -0.9535 1413251 TimTec1_003077 O=C(Oc1ccc(OCc2ccccc2)cc1)c3ccc(cc3)n4cnnn4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L20 compound treatment 1.43322775E8 480000.0 0.01 1.20720342E8 -2.99E7 -0.51 -0.3579 -0.6988 3084296 TimTec1_003078 CN(c1ccccc1)S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L21 compound treatment 1.15698657E8 -2.71E7 -0.34 1.31564259E8 -1.91E7 -0.33 -0.4717 -0.9998 1393226 TimTec1_003079 CC(=O)Nc1ccc(cc1)S(=O)(=O)NC2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L22 compound treatment 1.24972594E8 -1.79E7 -0.22 1.25977107E8 -2.47E7 -0.42 -0.4571 -0.9561 3084299 TimTec1_003080 CC(C)NS(=O)(=O)Cc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L23 mock treatment 1.25399486E8 -1.74E7 -0.22 1.14203079E8 -3.64E7 -0.62 -0.5958 -0.9013 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 L24 mock treatment 1.7657778E8 3.37E7 0.42 1.8279914E8 3.22E7 0.55 0.6885 0.9916 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M01 compound treatment 1.64920166E8 2.21E7 0.28 1.46096368E8 -4550000.0 -0.08 0.1408 0.4894 3209915 TimTec1_003081 CN(C)c1nc(Nc2ccc(OC(F)(F)F)cc2)nc(NC(C)(C)C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M02 compound treatment 1.69655777E8 2.68E7 0.34 1.47438429E8 -3210000.0 -0.05 0.199 0.584 1453611 TimTec1_003082 Fc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M03 compound treatment 1.81724013E8 3.89E7 0.49 1.05995394E8 -4.46E7 -0.76 -0.1955 -0.2157 1354508 TimTec1_003083 Fc1ccccc1NC(=O)OCC2CCCN3CCCCC23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M04 compound treatment 1.8428779E8 4.14E7 0.52 1.72695664E8 2.21E7 0.38 0.6345 0.9876 1291773 TimTec1_003084 COc1ccccc1NCC(=O)NN 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M05 compound treatment 1.82925834E8 4.01E7 0.5 1.64377618E8 1.37E7 0.24 0.5218 0.94 3209916 TimTec1_003085 FC(F)(F)COc1nc(NCCOC2(CC3CC4CC(C3)C2)C4)nc(OCC(F)(F)F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M06 compound treatment 1.72038127E8 2.92E7 0.37 1.63394132E8 1.28E7 0.22 0.4133 0.9694 3084303 TimTec1_003086 Cc1ccccc1OCC(=O)NC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M07 compound treatment 1.73590338E8 3.07E7 0.39 1.82023308E8 3.14E7 0.54 0.6526 0.9868 1483294 TimTec1_003087 Brc1ccc(o1)C(=O)N2CCCC2(C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M08 compound treatment 1.98769897E8 5.59E7 0.7 1.80130653E8 2.95E7 0.5 0.853 0.9869 3209917 TimTec1_003088 CCOC(=O)c1c(C)n(C)c2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M09 compound treatment 1.46696512E8 3850000.0 0.05 9.7952959E7 -5.27E7 -0.9 -0.6036 -0.6683 1608976 TimTec1_003089 Cc1ccc(CNC(=O)c2ccc(Cl)cc2)c(=S)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M10 compound treatment 1.23928421E8 -1.89E7 -0.24 1.22844758E8 -2.78E7 -0.48 -0.5043 -0.9483 1134765 TimTec1_003090 Cc1cc(ccc1NC(=O)C2CC2)c3ccc(NC(=O)C4CC4)c(C)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M11 compound treatment 1.36521253E8 -6320000.0 -0.08 1.77643305E8 2.7E7 0.46 0.2707 0.5773 1685257 TimTec1_003091 COc1ccc2[nH]c(C)c(CCNS(=O)(=O)c3c(C)[nH]c(=O)[nH]c3=O)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M12 compound treatment 9.1936433E7 -5.09E7 -0.64 1.16431344E8 -3.42E7 -0.59 -0.8657 -0.9991 1307859 TimTec1_003092 OC(=O)C1CC(=O)N(Cc2ccccc2)C1c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M13 compound treatment 1.08056515E8 -3.48E7 -0.44 1.55535545E8 4890000.0 0.08 -0.2494 -0.5612 1194234 TimTec1_003093 Nn1c(Cn2ccnc2)nnc1Cn3ccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M14 compound treatment 2.0280751E8 6.0E7 0.75 1.30616548E8 -2.0E7 -0.34 0.2895 0.3502 1004097 TimTec1_003094 O=C(Nc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M15 compound treatment 1.17099811E8 -2.57E7 -0.32 1.25130819E8 -2.55E7 -0.44 -0.5372 -0.989 3209918 TimTec1_003095 OC(=O)CSc1nc(O)c2ccccc2n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M16 compound treatment 1.21347225E8 -2.15E7 -0.27 1.701128E8 1.95E7 0.33 0.045 0.1049 1780824 TimTec1_003096 COC(=O)c1c(C)c(sc1N)/C(=C/C#N)/C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M17 compound treatment 1.62943411E8 2.01E7 0.25 1.70004575E8 1.94E7 0.33 0.4126 0.9909 3084309 TimTec1_003097 Cc1cc(C)c2C3=NC(NC(=O)N3Nc2n1)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M18 compound treatment 1.57402574E8 1.46E7 0.18 1.97007136E8 4.64E7 0.79 0.6903 0.8477 3209920 TimTec1_003098 CCC(=O)Nc1ccc(C#N)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M19 compound treatment 1.04544616E8 -3.83E7 -0.48 1.54473329E8 3830000.0 0.07 -0.2934 -0.605 3209921 TimTec1_003099 CCC(=O)c1ccc2cccc3nc(CC)[nH]c1c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M20 compound treatment 1.20464177E8 -2.24E7 -0.28 1.65910537E8 1.53E7 0.26 -0.0137 -0.0358 3084311 TimTec1_003100 CSc1nc(N)c(C#N)cc1C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M21 compound treatment 1.46745016E8 3900000.0 0.05 1.73901945E8 2.33E7 0.4 0.3161 0.7881 3084313 TimTec1_003101 FC(F)(F)c1cc(nc(SCCN2CCCCC2)c1C#N)C3CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M22 compound treatment 1.84350491E8 4.15E7 0.52 1.8496506E8 3.43E7 0.59 0.7836 0.9982 1363379 TimTec1_003102 Cc1cc(C)n(n1)C(=O)CCC(=O)NCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M23 mock treatment 1.72485985E8 2.96E7 0.37 1.15861499E8 -3.48E7 -0.6 -0.1581 -0.2252 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 M24 mock treatment 1.58991372E8 1.61E7 0.2 1.632918E8 1.26E7 0.22 0.2963 0.9994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N01 compound treatment 1.67636108E8 2.48E7 0.31 1.74676105E8 2.4E7 0.41 0.5108 0.9905 1876364 TimTec1_003103 COc1ccc2cc(ccc2c1)C(C)C(=O)OCC(=O)N3CCCc4ccccc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N02 compound treatment 4.2429948E7 -1.0E8 -1.26 1.7537406E8 2.47E7 0.42 -0.5914 -0.445 3083298 TimTec1_003104 CCc1ccc(NS(=O)(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N03 compound treatment 1.68041153E8 2.52E7 0.32 1.67556523E8 1.69E7 0.29 0.4282 0.999 3210033 TimTec1_003105 NC(=O)c1c(NC(=O)CCCc2ccccc2)scc1c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N04 compound treatment 1.02603562E8 -4.02E7 -0.5 1.83104155E8 3.25E7 0.56 0.036 0.0479 3083302 TimTec1_003106 FC(F)(F)c1ccccc1NC(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N05 compound treatment 1.59076973E8 1.62E7 0.2 9.3010223E7 -5.76E7 -0.99 -0.5536 -0.5496 3210034 TimTec1_003107 NC(=C(C#N)C#N)/C(=C/c1ccc(o1)c2cccc(c2)C(=O)O)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N06 compound treatment 1.61823361E8 1.9E7 0.24 1.1370192E8 -3.69E7 -0.63 -0.2788 -0.4126 1611585 TimTec1_003108 COc1ccc(OC)c(NC(=O)c2cccs2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N07 compound treatment 1.12902457E8 -2.99E7 -0.38 1.82050226E8 3.14E7 0.54 0.1146 0.1747 3210035 TimTec1_003109 COc1ccc(cc1)C(=O)CSc2nc3ccccc3c(=O)n2c4ccc(C)cc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N08 compound treatment 1.7306782E8 3.02E7 0.38 1.88747502E8 3.81E7 0.65 0.7293 0.9667 1483126 TimTec1_003110 CCN(C1CCCCC1)S(=O)(=O)c2ccc(C)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N09 compound treatment 1.56644646E8 1.38E7 0.17 1.68275249E8 1.76E7 0.3 0.3358 0.9652 3210036 TimTec1_003111 C/C(=N\N1CCN(CC1)C2c3ccccc3-c4ccccc24)/c5cccnc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N10 compound treatment 1.04944693E8 -3.79E7 -0.48 1.87633214E8 3.7E7 0.63 0.1116 0.1409 1438968 TimTec1_003112 COc1ccc(Cl)cc1NS(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N11 compound treatment 1.21946232E8 -2.09E7 -0.26 1.78971547E8 2.83E7 0.48 0.1575 0.2858 1569076 TimTec1_003113 Clc1cccc(NC(=O)C2(CCCCC2)NC(=O)Cc3ccccc3)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N12 compound treatment 1.30552342E8 -1.23E7 -0.15 1.82596803E8 3.2E7 0.55 0.2777 0.4887 3083307 TimTec1_003114 COc1ccc(cc1)S(=O)(=O)NC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N13 compound treatment 1.95615684E8 5.28E7 0.66 1.28791455E8 -2.19E7 -0.37 0.2036 0.2678 1576607 TimTec1_003115 CCC1(CC)OC(Nc2ccccc21)c3cccnc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N14 compound treatment 1.79152034E8 3.63E7 0.46 1.14971415E8 -3.57E7 -0.61 -0.1097 -0.144 1306106 TimTec1_003116 COc1ccc(CC(=O)N2CCc3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N15 compound treatment 1.63442631E8 2.06E7 0.26 1.7538084E8 2.47E7 0.42 0.4821 0.9719 1533234 TimTec1_003117 Oc1ccccc1N2CCN(CC2)C(=O)c3scc4CCCCc34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N16 compound treatment 9.9473085E7 -4.34E7 -0.54 1.36300853E8 -1.43E7 -0.25 -0.5583 -0.9354 3083310 TimTec1_003118 CN(Cc1ccccc1)S(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N17 compound treatment 1.08415754E8 -3.44E7 -0.43 1.1829857E8 -3.23E7 -0.55 -0.6969 -0.9924 1242242 TimTec1_003119 O=c1n(CN2CCOCC2)c3ccccc3n1CN4CCOCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N18 compound treatment 1.67155935E8 2.43E7 0.3 1.16307144E8 -3.43E7 -0.59 -0.2 -0.302 1434668 TimTec1_003120 CC(C)C(=O)N(Cc1ccccc1)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N19 compound treatment 1.08118099E8 -3.47E7 -0.44 1.22976092E8 -2.77E7 -0.47 -0.6429 -0.9991 1692260 TimTec1_003121 Cc1ccc(NC(=O)c2ccc(Oc3ccc(cc3)C(=O)Nc4ccc(C)cc4)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N20 compound treatment 1.12470524E8 -3.04E7 -0.38 1.68025645E8 1.74E7 0.3 -0.059 -0.1221 1530780 TimTec1_003122 COC(=O)c1cc(NS(=O)(=O)Cc2ccccc2)cc(c1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N21 compound treatment 1.1435403E8 -2.85E7 -0.36 1.73350191E8 2.27E7 0.39 0.0221 0.0419 1642760 TimTec1_003123 O=S(=O)(Nn1cnnc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N22 compound treatment 1.26274648E8 -1.66E7 -0.21 1.5812748E8 7480000.0 0.13 -0.0564 -0.2309 1190900 TimTec1_003124 COc1ccc(NS(=O)(=O)Cc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N23 mock treatment 1.63466074E8 2.06E7 0.26 1.75431078E8 2.48E7 0.42 0.483 0.9718 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 N24 mock treatment 1.16891775E8 -2.6E7 -0.33 1.66283913E8 1.56E7 0.27 -0.0409 -0.097 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O01 compound treatment 1.59325841E8 1.65E7 0.21 1.37912656E8 -1.27E7 -0.22 -0.0079 -0.0263 1591566 TimTec1_003125 Nn1cnn(CC(=O)Nc2nccs2)c1=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O02 compound treatment 1.63851599E8 2.1E7 0.26 1.6450817E8 1.39E7 0.24 0.3542 0.9986 1667880 TimTec1_003126 Fc1ccc(NC(=O)CCC(=O)Nc2ccc(F)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O03 compound treatment 1.72077453E8 2.92E7 0.37 1.8169991E8 3.11E7 0.53 0.6352 0.9836 1127183 TimTec1_003127 CN(C)C(=O)NC1CC(C)(C)N(O)C(C)(C)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O04 compound treatment 1.7494757E8 3.21E7 0.4 1.76442159E8 2.58E7 0.44 0.597 0.9989 3083316 TimTec1_003128 COC(=O)COc1cc(C)ccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O05 compound treatment 1.43631861E8 789000.0 0.01 1.65799455E8 1.52E7 0.26 0.1904 0.7335 1147462 TimTec1_003129 CN(Cc1nc(cs1)c2ccccc2)C(=O)NC3(CC3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O06 compound treatment 1.72661913E8 2.98E7 0.37 1.71308432E8 2.07E7 0.35 0.5146 0.9996 1412252 TimTec1_003130 Cc1ccccc1OCC(=O)NC2CCCCC2NC(=O)COc3ccccc3C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O07 compound treatment 1.3117662E8 -1.17E7 -0.15 1.80409716E8 2.98E7 0.51 0.2568 0.4844 1038833 TimTec1_003131 Cc1cc(C)c(C(=O)O)c(O)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O08 compound treatment 1.1358979E8 -2.93E7 -0.37 1.86214601E8 3.56E7 0.61 0.1711 0.2406 3083333 TimTec1_003132 C/C(=N/O)/c1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O09 compound treatment 1.5805702E8 1.52E7 0.19 1.98390028E8 4.77E7 0.82 0.7129 0.8494 1238150 TimTec1_003133 Cc1ccc(C)c(c1)N2C3CS(=O)(=O)CC3CC2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O10 compound treatment 1.60139428E8 1.73E7 0.22 1.86836449E8 3.62E7 0.62 0.5915 0.9011 3083335 TimTec1_003134 Nc1c[n+](no1)C2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O11 compound treatment 1.3297277E8 -9870000.0 -0.12 1.93581914E8 4.29E7 0.74 0.4322 0.5798 3210037 TimTec1_003135 COC(=O)CSc1ccc2c(N)c(sc2c1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O12 compound treatment 1.05343862E8 -3.75E7 -0.47 1.62664083E8 1.2E7 0.21 -0.1871 -0.3645 1652358 TimTec1_003136 CCC(=O)Nc1ccc(cc1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O13 compound treatment 1.22449741E8 -2.04E7 -0.26 1.10068636E8 -4.06E7 -0.69 -0.672 -0.9079 1308315 TimTec1_003137 COc1cc2cc3c(=O)oc(nc3nc2cc1OC)c4ccccc4F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O14 compound treatment 1.58773559E8 1.59E7 0.2 1.60762663E8 1.01E7 0.17 0.2638 0.9975 1329048 TimTec1_003138 Cc1cc(Br)ccc1OCC(=O)NCCC2=CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O15 compound treatment 1.90127624E8 4.73E7 0.59 1.13819089E8 -3.68E7 -0.63 -0.0263 -0.0304 3083338 TimTec1_003139 Oc1nc(SCC(=O)N2CCOCC2)nc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O16 compound treatment 1.31713176E8 -1.11E7 -0.14 2.11653919E8 6.1E7 1.04 0.6398 0.6072 3210038 TimTec1_003140 O/N=C/c1ccc2ccccc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O17 compound treatment 1.62496344E8 1.97E7 0.25 1.6510133E8 1.45E7 0.25 0.3493 1.0 1730029 TimTec1_003141 CC1CCN(CC1)S(=O)(=O)c2ccc(cc2)C(=O)NC3(CC4CC5CC(C4)C3)C5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O18 compound treatment 1.75736868E8 3.29E7 0.41 1.05359554E8 -4.53E7 -0.78 -0.2564 -0.2919 3083340 TimTec1_003142 N#CC[N+]1(CCN2CC1)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O19 compound treatment 1.70248025E8 2.74E7 0.34 2.0005639E8 4.94E7 0.85 0.8412 0.9213 3083341 TimTec1_003143 CC1(C)C=C(C(=O)N)C(C)(C)N1OC(=O)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O20 compound treatment 1.67607887E8 2.48E7 0.31 1.73436389E8 2.28E7 0.39 0.4956 0.9936 1600220 TimTec1_003144 CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O21 compound treatment 1.61477037E8 1.86E7 0.23 1.63219902E8 1.26E7 0.22 0.3175 0.9992 3083344 TimTec1_003145 CC(C)(C)C(=O)c1sc2nc(cc(c2c1N)C(F)(F)F)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O22 compound treatment 1.70325044E8 2.75E7 0.34 1.13102907E8 -3.75E7 -0.64 -0.2106 -0.2888 1287628 TimTec1_003146 COc1ccc(NC(=O)CCC(=O)Oc2ccc(C)cc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O23 mock treatment 1.23630811E8 -1.92E7 -0.24 1.70901076E8 2.03E7 0.35 0.0748 0.1771 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 O24 mock treatment 1.57654979E8 1.48E7 0.19 1.11243469E8 -3.94E7 -0.67 -0.3455 -0.4939 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P01 compound treatment 1.58152392E8 1.53E7 0.19 1.32830796E8 -1.78E7 -0.3 -0.0798 -0.2215 1410014 TimTec1_003147 Clc1ncccc1C(=O)NCCC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P02 compound treatment 1.22260224E8 -2.06E7 -0.26 1.15434591E8 -3.52E7 -0.6 -0.6088 -0.9284 1029200 TimTec1_003148 CN(C(=O)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P03 compound treatment 1.62270712E8 1.94E7 0.24 1.62559202E8 1.19E7 0.2 0.3166 0.9961 3210039 TimTec1_003149 Cc1ccc(C)c(c1)c2csc(NC(=O)CCCc3ccccc3)c2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P04 compound treatment 1.56306146E8 1.35E7 0.17 1.52267733E8 1620000.0 0.03 0.1391 0.8126 1021206 TimTec1_003150 O=C(Cc1ccccc1)NCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P05 compound treatment 1.91744613E8 4.89E7 0.61 1.85528314E8 3.49E7 0.6 0.856 0.9999 3083347 TimTec1_003151 COC(=O)c1cc(NC(=S)NN(C)C)ccc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P06 compound treatment 1.66792167E8 2.39E7 0.3 1.69862158E8 1.92E7 0.33 0.4451 0.999 3210040 TimTec1_003152 CC(C)(C)N(Cc1ccccc1)C(=O)c2cccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P07 compound treatment 1.26771966E8 -1.61E7 -0.2 1.17436057E8 -3.32E7 -0.57 -0.5445 -0.9028 3083349 TimTec1_003153 COc1ccc(CSc2nnc(SCc3ccc(cc3)C(=O)O)s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P08 compound treatment 1.91928409E8 4.91E7 0.62 1.72822897E8 2.22E7 0.38 0.7039 0.973 1063128 TimTec1_003154 Cc1ccc(cc1)S(=O)(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P09 compound treatment 1.74983608E8 3.21E7 0.4 1.76723269E8 2.61E7 0.45 0.6008 0.9987 3210041 TimTec1_003155 Sc1nnc(c2ccccc2)n1/N=C\c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P10 compound treatment 1.20653243E8 -2.22E7 -0.28 1.58562177E8 7920000.0 0.14 -0.101 -0.3262 3083351 TimTec1_003156 COc1ccccc1CNS(=O)(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P11 compound treatment 1.67979181E8 2.51E7 0.32 8.456986E7 -6.61E7 -1.13 -0.5768 -0.4912 1530173 TimTec1_003157 CC(C)(C)c1cc(Sc2nc(nc(n2)N3CCOCC3)N4CCOCC4)cc(c1O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P12 compound treatment 1.17046213E8 -2.58E7 -0.32 1.76048635E8 2.54E7 0.43 0.0787 0.1451 3083353 TimTec1_003158 CCN(CC)S(=O)(=O)c1c(C)cc(C)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P13 compound treatment 1.32282992E8 -1.06E7 -0.13 1.21504832E8 -2.91E7 -0.5 -0.4464 -0.8649 1546315 TimTec1_003159 Cc1c(CCNC2=CC(=O)OC32CCCCC3)c4ccccc4n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P14 compound treatment 1.77684449E8 3.48E7 0.44 1.80342716E8 2.97E7 0.51 0.6685 0.9972 1177659 TimTec1_003160 Cc1cccc(c1)C(=O)N2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P15 compound treatment 1.69373363E8 2.65E7 0.33 1.63067826E8 1.24E7 0.21 0.3857 0.9766 3210042 TimTec1_003161 CC(C)c1cc(C)ccc1OCCSc2nc(N)cc(N)n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P16 compound treatment 1.29653799E8 -1.32E7 -0.17 1.25807066E8 -2.48E7 -0.43 -0.4176 -0.9154 3083357 TimTec1_003162 COC(=O)CNC(=O)c1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P17 compound treatment 1.60255296E8 1.74E7 0.22 1.70579787E8 1.99E7 0.34 0.3958 0.9768 1308187 TimTec1_003163 Cc1cc(C)n(n1)c2ccc(Cl)c(c2)C(=O)OCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P18 compound treatment 1.17259028E8 -2.56E7 -0.32 1.85052275E8 3.44E7 0.59 0.1895 0.2826 3083360 TimTec1_003164 CC(C)C(=O)N1CCCCCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P19 compound treatment 1.62321743E8 1.95E7 0.24 1.4690273E8 -3740000.0 -0.06 0.1275 0.5047 1157157 TimTec1_003165 Cc1ccc(C)n1c2cccc(c2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P20 compound treatment 1.61606138E8 1.88E7 0.24 1.61745546E8 1.11E7 0.19 0.3008 0.9944 1466847 TimTec1_003166 COc1ccccc1N2CCN(CC2)S(=O)(=O)Cc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P21 compound treatment 1.59918164E8 1.71E7 0.21 1.71287297E8 2.06E7 0.35 0.4013 0.9712 3210043 TimTec1_003167 CC1CCN(CC1)C(=O)c2ccccc2Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P22 compound treatment 1.96572427E8 5.37E7 0.67 1.57275313E8 6630000.0 0.11 0.5569 0.8147 1611033 TimTec1_003168 Cc1ccccc1NS(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P23 mock treatment 1.69087339E8 2.62E7 0.33 1.63478087E8 1.28E7 0.22 0.3881 0.9807 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2071 P24 mock treatment 2.09209562E8 6.64E7 0.83 1.72137016E8 2.15E7 0.37 0.8488 0.9326 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A01 compound treatment 1.44776916E8 4230000.0 0.05 1.43838307E8 -2770000.0 -0.05 0.004 0.0564 1249702 TimTec1_003169 CC1CCCCN1S(=O)(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A02 compound treatment 1.43525336E8 2980000.0 0.04 1.30155013E8 -1.65E7 -0.28 -0.1727 -0.6078 3210166 TimTec1_003170 CCC(C(=O)N(C)c1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A03 compound treatment 1.50500051E8 9960000.0 0.12 1.38372163E8 -8240000.0 -0.14 -0.0114 -0.0604 1568702 TimTec1_003171 Cc1ccc(cc1C)C(=O)NCC2CCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A04 compound treatment 1.50027223E8 9480000.0 0.12 1.42466965E8 -4140000.0 -0.07 0.034 0.2454 1300542 TimTec1_003172 O=C(CN1C(=O)c2ccccc2C1=O)NCC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A05 compound treatment 1.58088928E8 1.75E7 0.22 1.56132876E8 9520000.0 0.16 0.2709 0.9891 3210167 TimTec1_003173 COc1cccc(c1)C(=O)N(CC=C)CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A06 compound treatment 1.81149687E8 4.06E7 0.51 1.67267779E8 2.07E7 0.35 0.6102 0.9841 3083365 TimTec1_003174 CN(C)S(=O)(=O)NCc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A07 compound treatment 1.81301958E8 4.08E7 0.51 1.4529127E8 -1320000.0 -0.02 0.3456 0.6752 3083366 TimTec1_003175 CC(=O)N1CCc2ccccc2C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A08 compound treatment 1.59358522E8 1.88E7 0.24 1.61464092E8 1.49E7 0.25 0.3467 0.9993 3210168 TimTec1_003176 CC1CC(C)CN(C1)C(=O)CCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A09 compound treatment 1.6082184E8 2.03E7 0.25 1.58230045E8 1.16E7 0.2 0.3205 0.9926 1737672 TimTec1_003177 O=C(CC(c1ccccc1)c2ccccc2)NCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A10 compound treatment 1.94726847E8 5.42E7 0.68 1.46810595E8 201000.0 0.0 0.4831 0.7107 3083369 TimTec1_003178 CCN(C(=O)CC(C)(C)C)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A11 compound treatment 1.70845324E8 3.03E7 0.38 1.58978359E8 1.24E7 0.21 0.4185 0.9618 1464313 TimTec1_003179 CCc1ccc(NC(=O)c2ccc3OCOc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A12 compound treatment 1.59876709E8 1.93E7 0.24 1.51096215E8 4490000.0 0.08 0.2258 0.8876 1608343 TimTec1_003180 COc1cc(SC)ccc1C(=O)Nc2ccccc2C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A13 compound treatment 1.4618032E8 5640000.0 0.07 1.4450737E8 -2100000.0 -0.04 0.0246 0.3095 1728662 TimTec1_003181 CC(=O)Nc1ccc(NC(=O)CC(c2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A14 compound treatment 1.86506602E8 4.6E7 0.58 1.50125011E8 3520000.0 0.06 0.4503 0.7767 1565572 TimTec1_003182 CCOC(=O)C1CCCN(C1)C(=O)c2cccc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A15 compound treatment 1.53115898E8 1.26E7 0.16 1.39734151E8 -6880000.0 -0.12 0.0283 0.1438 1573195 TimTec1_003183 CC(C)c1ccc(NS(=O)(=O)Cc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A16 compound treatment 1.71964985E8 3.14E7 0.39 1.40624996E8 -5980000.0 -0.1 0.2063 0.5065 1133863 TimTec1_003184 COCC(C)NC(=O)c1ccc(NC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A17 compound treatment 1.54033497E8 1.35E7 0.17 1.54547279E8 7940000.0 0.14 0.2157 0.9941 1299790 TimTec1_003185 CC(Oc1ccccc1)C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A18 compound treatment 1.69030619E8 2.85E7 0.36 1.597123E8 1.31E7 0.22 0.4113 0.9748 1542766 TimTec1_003186 CCOC(=O)c1cccc(NC(=O)CCc2ccccc2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A19 compound treatment 1.52363592E8 1.18E7 0.15 1.56814529E8 1.02E7 0.17 0.2284 0.9967 1681120 TimTec1_003187 CCC(C)C(=O)N1CCN(CC1)c2cccc(Cl)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A20 compound treatment 1.63033973E8 2.25E7 0.28 1.51114544E8 4500000.0 0.08 0.254 0.8685 3210169 TimTec1_003188 Cn1nc(cc1C(=O)O)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A21 compound treatment 1.64210616E8 2.37E7 0.3 9.5130474E7 -5.15E7 -0.88 -0.4132 -0.4443 3083375 TimTec1_003189 CCC(C)C(=O)Nc1cccc(c1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A22 compound treatment 3.00922826E8 1.6E8 2.01 2.74068007E8 1.27E8 2.18 2.9654 0.9992 1652746 TimTec1_003190 COc1ccc(cc1)C2C=C(NC(=O)C2C#N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A23 mock treatment 1.53589313E8 1.3E7 0.16 1.54356203E8 7750000.0 0.13 0.2095 0.9945 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 A24 mock treatment 1.241383E8 -1.64E7 -0.21 1.41356535E8 -5250000.0 -0.09 -0.2091 -0.9311 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B01 compound treatment 1.43339544E8 2800000.0 0.04 1.46406188E8 -204000.0 0.0 0.0223 0.6337 1388587 TimTec1_003191 O=S(=O)(NCCN1CCOCC1)c2ccc3ccccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B02 compound treatment 1.4152577E8 983000.0 0.01 1.39044751E8 -7570000.0 -0.13 -0.0828 -0.6369 1707122 TimTec1_003192 COc1cc(cc(Cl)c1O)C2CSc3nc4sc5CCCCc5c4c(=O)n23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B03 compound treatment 1.00057554E8 -4.05E7 -0.51 1.36641265E8 -9970000.0 -0.17 -0.4798 -0.8955 1004002 TimTec1_003193 Nc1ccc(I)cc1C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B04 compound treatment 7.9318107E7 -6.12E7 -0.77 1.06054409E8 -4.06E7 -0.69 -1.034 -0.9987 1150946 TimTec1_003194 O=C1CC(C2COC1O2)N3c4cccc5cccc(c45)S3(=O)=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B05 compound treatment 1.03194847E8 -3.73E7 -0.47 1.49469845E8 2860000.0 0.05 -0.2967 -0.6298 1120723 TimTec1_003195 CC(=O)Nc1cccc(OC(=O)c2ccoc2C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B06 compound treatment 9.7026414E7 -4.35E7 -0.55 1.49527861E8 2920000.0 0.05 -0.3507 -0.6397 1185449 TimTec1_003196 CCCC(C(=O)N)C1=NC2(CCCCC2)Cc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B07 compound treatment 9.6846469E7 -4.37E7 -0.55 1.62427736E8 1.58E7 0.27 -0.1961 -0.3208 3083393 TimTec1_003197 Fc1ccc(CSc2nnc(SCc3ccccc3)s2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B08 compound treatment 1.01031047E8 -3.95E7 -0.5 1.26000036E8 -2.06E7 -0.35 -0.5999 -0.9861 3210170 TimTec1_003198 OC(=O)c1ccc(/C=N/N2C(=O)c3cccc4cccc(C2=O)c34)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B09 compound treatment 1.21261705E8 -1.93E7 -0.24 1.02540417E8 -4.41E7 -0.75 -0.7045 -0.8892 3083394 TimTec1_003199 FC(F)(F)C(NC(=O)c1ccco1)(NC2=NCCS2)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B10 compound treatment 1.22630995E8 -1.79E7 -0.22 1.4029312E8 -6320000.0 -0.11 -0.2353 -0.9438 3210171 TimTec1_003200 Cc1nn(C)c(C)c1/C=C/C(=O)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B11 compound treatment 1.60639639E8 2.01E7 0.25 1.08948879E8 -3.77E7 -0.64 -0.2776 -0.401 3210172 TimTec1_003201 COc1ccc(cc1)C2=C(Nc3ccc(cc3)C(=O)N4CCOCC4)c5ccccc5C2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B12 compound treatment 3.3860913E7 -1.07E8 -1.34 4.1541093E7 -1.05E8 -1.8 -2.2181 -0.9894 1429954 TimTec1_003202 CC(=O)ON1C(=O)c2cccc3c(Br)ccc(C1=O)c23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B13 compound treatment 1.09979827E8 -3.06E7 -0.38 1.38571836E8 -8040000.0 -0.14 -0.3684 -0.9044 1329559 TimTec1_003203 COC(=O)c1ccccc1N(C)C(=O)c2cccc(c2)S(=O)(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B14 compound treatment 1.14027715E8 -2.65E7 -0.33 1.44954362E8 -1660000.0 -0.03 -0.2552 -0.7646 1642501 TimTec1_003204 CC(C)c1ccc(Nc2nc(nc(n2)N3CCCCC3)N4CCCCC4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B15 compound treatment 1.24412683E8 -1.61E7 -0.2 1.25693695E8 -2.09E7 -0.36 -0.3962 -0.9635 3083396 TimTec1_003205 CC/N=C/1\SC(CC(=O)N1CC)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B16 compound treatment 1.28821511E8 -1.17E7 -0.15 1.36070733E8 -1.05E7 -0.18 -0.2315 -0.9948 1410726 TimTec1_003206 COc1cccc(c1)c2nnc(SCc3ccc(cc3)C(=O)O)n2CC=C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B17 compound treatment 1.03976982E8 -3.66E7 -0.46 1.4383009E8 -2780000.0 -0.05 -0.358 -0.7763 3083397 TimTec1_003207 FC(F)(F)c1cccc(c1)c2nc3ccccc3[nH]2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B18 compound treatment 1.02462479E8 -3.81E7 -0.48 1.18291718E8 -2.83E7 -0.48 -0.6805 -1.0 3210173 TimTec1_003208 COC(=O)c1ccc(/C=C/2\SC(=N)NC2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B19 compound treatment 1.12983164E8 -2.76E7 -0.35 1.5348853E8 6880000.0 0.12 -0.1612 -0.4414 3210174 TimTec1_003209 OC1(CC(NO1)c2ccccc2)C3(O)CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B20 compound treatment 1.22248966E8 -1.83E7 -0.23 1.18283493E8 -2.83E7 -0.48 -0.5051 -0.9416 1622985 TimTec1_003210 O=C1C2CC=CCC2C(=O)N1C3CC(=O)C4OCC3O4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B21 compound treatment 1.20323377E8 -2.02E7 -0.25 1.50883268E8 4270000.0 0.07 -0.1276 -0.4835 1582803 TimTec1_003211 Nn1c(COc2ccc(Cl)cc2)nc3ccccc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B22 compound treatment 1.61593259E8 2.11E7 0.26 1.48370585E8 1760000.0 0.03 0.208 0.7827 3083401 TimTec1_003212 OC(=O)CCc1nn2c3ccccc3nc2[nH]c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B23 mock treatment 1.70163834E8 2.96E7 0.37 1.46492856E8 -117000.0 0.0 0.2613 0.7033 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 B24 mock treatment 1.54676695E8 1.41E7 0.18 1.50274002E8 3660000.0 0.06 0.1697 0.9024 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C01 compound treatment 1.38506575E8 -2040000.0 -0.03 1.22585322E8 -2.4E7 -0.41 -0.3089 -0.7496 1543604 TimTec1_003213 O=S(=O)(Cc1ccccc1)Nc2nc3ccccc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C02 compound treatment 8.71918E7 -5.34E7 -0.67 1.35789107E8 -1.08E7 -0.19 -0.6042 -0.8701 3083402 TimTec1_003214 CN(C(=O)Cc1cccs1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C03 compound treatment 8.4252585E7 -5.63E7 -0.71 1.47154841E8 545000.0 0.01 -0.4927 -0.6977 1605314 TimTec1_003215 CCCNC(=O)c1ccc(OCC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C04 compound treatment 6.7341593E7 -7.32E7 -0.92 7.0590279E7 -7.6E7 -1.3 -1.5695 -0.9854 1295085 TimTec1_003216 O=C(COc1ccccc1)N(Cc2ccccc2)c3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C05 compound treatment 7.432405E7 -6.62E7 -0.83 1.35148181E8 -1.15E7 -0.2 -0.7261 -0.8507 3083405 TimTec1_003217 COc1cccc(c1)C(=O)N2CCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C06 compound treatment 8.4386045E7 -5.62E7 -0.7 8.7251619E7 -5.94E7 -1.02 -1.2166 -0.984 3210175 TimTec1_003218 CC(C)CC(=O)NCc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C07 compound treatment 7.1966708E7 -6.86E7 -0.86 8.234224E7 -6.43E7 -1.1 -1.3862 -0.9926 3083407 TimTec1_003219 CCCNC(=O)c1ccccc1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C08 compound treatment 7.9452341E7 -6.11E7 -0.77 1.00892064E8 -4.57E7 -0.78 -1.0953 -0.9999 3210176 TimTec1_003220 CCN(C(=O)CCc1ccccc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C09 compound treatment 8.5184843E7 -5.54E7 -0.69 9.0816407E7 -5.58E7 -0.96 -1.1664 -0.9877 1655477 TimTec1_003221 O=C(CC(c1ccccc1)c2ccccc2)Nc3ccccn3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C10 compound treatment 8.3520818E7 -5.7E7 -0.72 8.5215137E7 -6.14E7 -1.05 -1.2489 -0.9824 1506281 TimTec1_003222 COc1cc(NC(=O)CC(C)(C)C)c(OC)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C11 compound treatment 7.9837601E7 -6.07E7 -0.76 1.00039822E8 -4.66E7 -0.8 -1.1022 -0.9997 1163628 TimTec1_003223 CCN(CC)C(=O)C1c2ccccc2Oc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C12 compound treatment 6.9171174E7 -7.14E7 -0.9 8.2865006E7 -6.37E7 -1.09 -1.4047 -0.9952 3083410 TimTec1_003224 CCC(C)C(=O)NCCc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C13 compound treatment 7.4494765E7 -6.6E7 -0.83 1.03534944E8 -4.31E7 -0.74 -1.1073 -0.9983 3210177 TimTec1_003225 CCOc1ccc(cc1)C(=O)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C14 compound treatment 8.6108399E7 -5.44E7 -0.68 9.6425142E7 -5.02E7 -0.86 -1.0903 -0.9935 3083413 TimTec1_003226 COCC(C)NC(=O)c1cccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C15 compound treatment 7.961926E7 -6.09E7 -0.76 9.8623281E7 -4.8E7 -0.82 -1.1212 -0.9994 3210178 TimTec1_003227 CC(C)CCNC(=O)c1ccccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C16 compound treatment 7.0338477E7 -7.02E7 -0.88 9.8248973E7 -4.84E7 -0.83 -1.2081 -0.9995 1703463 TimTec1_003228 COCC(C)NC(=O)c1ccc(OC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C17 compound treatment 7.5771973E7 -6.48E7 -0.81 1.482705E8 1660000.0 0.03 -0.5544 -0.6819 1178243 TimTec1_003229 CCC(C(=O)NCc1ccccn1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C18 compound treatment 6.3334044E7 -7.72E7 -0.97 1.03261612E8 -4.33E7 -0.74 -1.2096 -0.9913 1572580 TimTec1_003230 CCOC(=O)C1CCCN(C1)C(=O)CCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C19 compound treatment 5.8205147E7 -8.23E7 -1.03 1.01775622E8 -4.48E7 -0.77 -1.273 -0.9893 3083416 TimTec1_003231 CC(C)N(Cc1ccccc1)S(=O)(=O)N(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C20 compound treatment 7.5747396E7 -6.48E7 -0.81 1.32171279E8 -1.44E7 -0.25 -0.7495 -0.8822 1144496 TimTec1_003232 C=CCN(CC=C)C(=O)C1c2ccccc2Oc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C21 compound treatment 8.4503713E7 -5.6E7 -0.7 1.40299709E8 -6310000.0 -0.11 -0.5735 -0.8063 3083418 TimTec1_003233 Brc1ccc(CC(=O)N(CC=C)CC=C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C22 compound treatment 7.3477688E7 -6.71E7 -0.84 1.1610907E8 -3.05E7 -0.52 -0.9641 -0.9737 1605852 TimTec1_003234 CCOC(=O)N1CCN(CC1)c2ccc3ccccc3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C23 mock treatment 6.5700395E7 -7.48E7 -0.94 9.1486173E7 -5.51E7 -0.94 -1.3311 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 C24 mock treatment 8.2644332E7 -5.79E7 -0.73 6.9783633E7 -7.68E7 -1.32 -1.4435 -0.9608 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D01 compound treatment 9.0098026E7 -5.04E7 -0.63 8.5221892E7 -6.14E7 -1.05 -1.1905 -0.9705 3083420 TimTec1_003235 Cc1cccc(C)c1NC(=O)CCCSc2nnnn2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D02 compound treatment 8.2433915E7 -5.81E7 -0.73 8.0155412E7 -6.65E7 -1.14 -1.3198 -0.9769 1267320 TimTec1_003236 O=C1CC(C2COC1O2)n3nc(Nc4ccccc4)n(c5ccccc5)c3=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D03 compound treatment 8.457908E7 -5.6E7 -0.7 8.5497422E7 -6.11E7 -1.05 -1.2361 -0.9812 3083422 TimTec1_003237 CN1[C@@H]([C@H](CC1=O)C(=O)O)c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D04 compound treatment 8.2789559E7 -5.78E7 -0.72 8.640036E7 -6.02E7 -1.03 -1.2411 -0.9851 3210297 TimTec1_003238 Cc1[nH]c2ccccc2c1CCNCC(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D05 compound treatment 7.5367781E7 -6.52E7 -0.82 9.1537193E7 -5.51E7 -0.94 -1.2447 -0.9975 1689355 TimTec1_003239 COc1ccc(NC(=O)NC2c3ccccc3Oc4ccccc24)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D06 compound treatment 7.6792625E7 -6.37E7 -0.8 7.7995167E7 -6.86E7 -1.17 -1.396 -0.9824 3083425 TimTec1_003240 Cc1nnc(c2ccccc2)c(=O)n1/N=C/c3ccc4OCOc4c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D07 compound treatment 7.6007706E7 -6.45E7 -0.81 8.1141173E7 -6.55E7 -1.12 -1.3649 -0.9873 1601274 TimTec1_003241 Cc1ccc(cc1)n2c(SCC(=O)N)nc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D08 compound treatment 8.3233742E7 -5.73E7 -0.72 8.6148758E7 -6.05E7 -1.03 -1.2402 -0.9841 1532590 TimTec1_003242 C(NC1CCCCC1)c2cccn2c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D09 compound treatment 9.3389872E7 -4.72E7 -0.59 1.11158652E8 -3.55E7 -0.61 -0.8474 -0.9999 3210298 TimTec1_003243 NNc1nc(NN)nc(Nc2cccc(c2)C(F)(F)F)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D10 compound treatment 7.7481707E7 -6.31E7 -0.79 8.7978158E7 -5.86E7 -1.0 -1.2691 -0.9931 3083428 TimTec1_003244 Cc1cc(n2ncnc2n1)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D11 compound treatment 8.21744E7 -5.84E7 -0.73 1.31591794E8 -1.5E7 -0.26 -0.6995 -0.9014 3210299 TimTec1_003245 NC1=C(C#N)C(C2=C(CCC2)N1c3sc4CCCCc4c3C#N)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D12 compound treatment 7.4101467E7 -6.64E7 -0.83 9.6785082E7 -4.98E7 -0.85 -1.1924 -0.9999 3083430 TimTec1_003246 COc1ccc(cc1)C2CC(=NO2)C3(C)CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D13 compound treatment 7.2342665E7 -6.82E7 -0.86 8.7539719E7 -5.91E7 -1.01 -1.32 -0.9965 1610817 TimTec1_003247 CCC1OC(=Nc2ccccc12)c3cccc(OC)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D14 compound treatment 7.2373672E7 -6.82E7 -0.86 1.09657592E8 -3.7E7 -0.63 -1.052 -0.989 3083432 TimTec1_003248 Cc1ccc(CCSc2ccc(Cl)c(Cl)c2)cn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D15 compound treatment 8.5387139E7 -5.52E7 -0.69 1.38913975E8 -7700000.0 -0.13 -0.5824 -0.8269 3210300 TimTec1_003249 Cc1c(CCNC(NC(=O)c2ccc(Cl)cc2)(C(F)(F)F)C(F)(F)F)c3ccccc3n1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D16 compound treatment 9.0955217E7 -4.96E7 -0.62 1.24571507E8 -2.2E7 -0.38 -0.7066 -0.9713 3083457 TimTec1_003250 Brc1ccc(CSc2nccn2Cc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D17 compound treatment 8.1431685E7 -5.91E7 -0.74 7.6379803E7 -7.02E7 -1.2 -1.3744 -0.973 1520066 TimTec1_003251 CC1CCCN(C1C)S(=O)(=O)c2cccc3c(cccc23)S(=O)(=O)N4CCCC(C)C4C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D18 compound treatment 5.7885668E7 -8.27E7 -1.04 7.9525026E7 -6.71E7 -1.15 -1.5452 -0.9987 3083459 TimTec1_003252 NC(=O)SCC(=O)Nc1ccc(Cl)cc1Cl 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D19 compound treatment 8.2831152E7 -5.77E7 -0.72 7.9817638E7 -6.68E7 -1.14 -1.3204 -0.9757 3210301 TimTec1_003253 Nc1cc(=O)[nH]c(S/C=C/c2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D20 compound treatment 7.8515911E7 -6.2E7 -0.78 8.0683264E7 -6.59E7 -1.13 -1.3482 -0.9835 3083461 TimTec1_003254 C=CCS/C(=N\n1cnc2ccccc2c1=O)/N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D21 compound treatment 7.0375044E7 -7.02E7 -0.88 7.4150902E7 -7.25E7 -1.24 -1.4995 -0.9859 1275489 TimTec1_003255 CCOC(=O)C1=C(NC(=O)C(C#N)C21CCCCC2)SCc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D22 compound treatment 8.0301851E7 -6.02E7 -0.76 8.9645588E7 -5.7E7 -0.98 -1.2239 -0.9921 1429911 TimTec1_003256 O=C(CSc1nc2ccccc2s1)Nc3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D23 mock treatment 7.3258494E7 -6.73E7 -0.84 1.02326799E8 -4.43E7 -0.76 -1.1328 -0.9986 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 D24 mock treatment 6.8994031E7 -7.15E7 -0.9 9.315763E7 -5.35E7 -0.91 -1.2817 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E01 compound treatment 1.55162587E8 1.46E7 0.18 1.33574879E8 -1.3E7 -0.22 -0.0281 -0.0973 1553246 TimTec1_003257 Brc1cccc(c1)C(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E02 compound treatment 1.62833938E8 2.23E7 0.28 1.47148545E8 539000.0 0.01 0.2043 0.73 3083464 TimTec1_003258 CN(C)S(=O)(=O)N(C)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E03 compound treatment 1.87442703E8 4.69E7 0.59 1.5565717E8 9050000.0 0.15 0.5255 0.8638 1180821 TimTec1_003259 CCOc1ccc(cc1)C(=O)NC(C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E04 compound treatment 1.85150786E8 4.46E7 0.56 1.2311007E8 -2.35E7 -0.4 0.1112 0.1614 1212826 TimTec1_003260 CCOC(=O)C1CCN(CC1)C(=O)COc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E05 compound treatment 1.24890385E8 -1.57E7 -0.2 1.58166035E8 1.16E7 0.2 0.001 0.0037 3210302 TimTec1_003261 CCN(CC)C(=O)c1cccc(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E06 compound treatment 1.47596775E8 7050000.0 0.09 1.42656739E8 -3950000.0 -0.07 0.0147 0.1322 3210303 TimTec1_003262 CCCC(C)C(=O)NCc1ccc(C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E07 compound treatment 1.64925654E8 2.44E7 0.31 1.78566177E8 3.2E7 0.55 0.6031 0.9623 1476178 TimTec1_003263 CC1CC(C)CN(C1)C(=O)c2ccccc2OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E08 compound treatment 1.23787806E8 -1.68E7 -0.21 1.55162052E8 8550000.0 0.15 -0.0451 -0.1761 3210304 TimTec1_003264 CCN(C1CCCCC1)C(=O)CCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E09 compound treatment 1.68651486E8 2.81E7 0.35 1.64340649E8 1.77E7 0.3 0.464 0.9972 1131761 TimTec1_003265 COc1ccccc1CC(=O)NC2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E10 compound treatment 1.32708508E8 -7830000.0 -0.1 1.79324678E8 3.27E7 0.56 0.3265 0.5742 1709116 TimTec1_003266 CC(C)(C)CC(=O)NCc1ccc(cc1)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E11 compound treatment 1.35550251E8 -4990000.0 -0.06 1.56098619E8 9490000.0 0.16 0.0706 0.4054 1613437 TimTec1_003267 O=C(NC1CCCC1)C2c3ccccc3Oc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E12 compound treatment 1.50112947E8 9570000.0 0.12 1.66894735E8 2.03E7 0.35 0.3304 0.8994 1434161 TimTec1_003268 CCCC(C)C(=O)Nc1ccc(cc1)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E13 compound treatment 1.70983226E8 3.04E7 0.38 1.60349779E8 1.37E7 0.24 0.4363 0.9729 1616704 TimTec1_003269 NC(=O)c1ccccc1NC(=O)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E14 compound treatment 1.35849273E8 -4690000.0 -0.06 1.72569537E8 2.6E7 0.44 0.2726 0.6081 1260520 TimTec1_003270 CCOC(=O)C1CCCN(C1)S(=O)(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E15 compound treatment 1.34221198E8 -6320000.0 -0.08 1.30676603E8 -1.59E7 -0.27 -0.2489 -0.8764 3083469 TimTec1_003271 CC(C)CCNC(=O)c1cccc(Cl)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E16 compound treatment 1.34241376E8 -6300000.0 -0.08 1.71400809E8 2.48E7 0.42 0.2442 0.5657 1590237 TimTec1_003272 CCC(CC)NC(=O)Cc1ccccc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E17 compound treatment 1.23841465E8 -1.67E7 -0.21 1.75951661E8 2.93E7 0.5 0.207 0.3804 1731442 TimTec1_003273 CC(C)(C)CC(=O)NCc1ccccn1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E18 compound treatment 1.34805179E8 -5740000.0 -0.07 1.70810089E8 2.42E7 0.41 0.242 0.5756 1659601 TimTec1_003274 CCOC(=O)c1cccc(NC(=O)C(C)(C)CC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E19 compound treatment 1.6729828E8 2.68E7 0.34 1.70040274E8 2.34E7 0.4 0.5209 0.9961 1275025 TimTec1_003275 CC(C)N(Cc1ccccc1)C(=O)COc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E20 compound treatment 1.30482532E8 -1.01E7 -0.13 1.28207264E8 -1.84E7 -0.32 -0.312 -0.9194 1917477 TimTec1_003276 CC(=O)N1[C@@H](CS[C@@H]1c2ccc(F)cc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E21 compound treatment 1.18604478E8 -2.19E7 -0.28 1.60271383E8 1.37E7 0.23 -0.0292 -0.0809 3210305 TimTec1_003277 CC(NS(=O)(=O)N(C)C)c1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E22 compound treatment 1.16504758E8 -2.4E7 -0.3 1.65077422E8 1.85E7 0.32 0.0103 0.0236 1301346 TimTec1_003278 CC(=O)Nc1ccc(OS(=O)Nc2nnc(C)c3ccccc23)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E23 mock treatment 1.68777699E8 2.82E7 0.35 1.43449343E8 -3160000.0 -0.05 0.2122 0.5922 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 E24 mock treatment 1.57518961E8 1.7E7 0.21 1.81891575E8 3.53E7 0.6 0.5776 0.902 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F01 compound treatment 1.47010778E8 6470000.0 0.08 1.26073885E8 -2.05E7 -0.35 -0.1912 -0.53 3210306 TimTec1_003279 COc1ccc(NC(=O)Cn2cnc3ccccc3c2=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F02 compound treatment 1.42343474E8 1800000.0 0.02 1.48903097E8 2290000.0 0.04 0.0437 0.9656 3210307 TimTec1_003280 CCC(NS(=O)(=O)c1c(C)[nH]c(=O)[nH]c1=O)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F03 compound treatment 1.04904307E8 -3.56E7 -0.45 1.51470068E8 4860000.0 0.08 -0.2573 -0.5658 1357383 TimTec1_003281 CC(=CCNc1ncnc2nc[nH]c12)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F04 compound treatment 1.10063261E8 -3.05E7 -0.38 1.59689374E8 1.31E7 0.22 -0.112 -0.2529 1458922 TimTec1_003282 COc1ccc(CCNC(=O)Cc2c(SC)c3ccccc3n2Cc4ccccc4)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F05 compound treatment 1.2390592E8 -1.66E7 -0.21 1.1926189E8 -2.73E7 -0.47 -0.4786 -0.9338 3210308 TimTec1_003283 CC(C)(C)N1C(=O)NC(=O)/C(=C/c2cc3ccccc3[nH]2)/C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F06 compound treatment 1.17590485E8 -2.3E7 -0.29 1.68123063E8 2.15E7 0.37 0.0568 0.1215 1611563 TimTec1_003284 Cc1cc(c2ncccc2c1)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F07 compound treatment 1.12348457E8 -2.82E7 -0.35 1.05370604E8 -4.12E7 -0.71 -0.7493 -0.9489 1415079 TimTec1_003285 Cc1ccc(cc1)n2c(SCC(=O)Nc3c(C)cccc3C)nc4ccccc4c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F08 compound treatment 1.18748914E8 -2.18E7 -0.27 1.36496372E8 -1.01E7 -0.17 -0.3157 -0.9757 1631498 TimTec1_003286 COC(=O)c1ccc2nc(NC(=O)CN3C(=O)CCC3=O)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F09 compound treatment 9.6935981E7 -4.36E7 -0.55 1.58748172E8 1.21E7 0.21 -0.2399 -0.4099 1658377 TimTec1_003287 C1CC1C#CC(N2CCOCC2)N3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F10 compound treatment 1.36179195E8 -4360000.0 -0.05 1.20428169E8 -2.62E7 -0.45 -0.3556 -0.7876 1133097 TimTec1_003288 COC(=O)CNS(=O)(=O)c1ccc(I)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F11 compound treatment 1.60250752E8 1.97E7 0.25 1.50016352E8 3410000.0 0.06 0.2161 0.8505 3210422 TimTec1_003289 COc1ccc(/C=C\2/C3CCC(C)(C2=O)C3(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F12 compound treatment 8.8324097E7 -5.22E7 -0.66 1.01295731E8 -4.53E7 -0.78 -1.0117 -0.9965 1395696 TimTec1_003290 CCOC(=O)Oc1c(Cl)cc2oc(=O)sc2c1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F13 compound treatment 1.1225871E8 -2.83E7 -0.35 1.67600863E8 2.1E7 0.36 0.0032 0.0063 1432636 TimTec1_003291 Clc1ccc(cc1)C(=O)CCNc2ccc(Cc3ccncc3)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F14 compound treatment 9.7208248E7 -4.33E7 -0.54 1.48631821E8 2020000.0 0.03 -0.3599 -0.6607 3083482 TimTec1_003292 CC(=O)N/C(=C/c1ccccc1)/C(=O)Nc2ccc(I)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F15 compound treatment 1.62033088E8 2.15E7 0.27 1.55790582E8 9180000.0 0.16 0.3018 0.967 1541061 TimTec1_003293 Cn1c(SCc2ccc3OCOc3c2)nc4ccccc4c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F16 compound treatment 9.8979772E7 -4.16E7 -0.52 1.67313923E8 2.07E7 0.35 -0.1181 -0.1873 1611110 TimTec1_003294 O=C(CSc1nc2ccccc2o1)OCC(=O)N3c4ccccc4Sc5ccccc35 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F17 compound treatment 1.56554797E8 1.6E7 0.2 1.12730711E8 -3.39E7 -0.58 -0.268 -0.4367 1592970 TimTec1_003295 CC(C)CSc1cc(cc(c1C)S(=O)(=O)c2ccccc2)N3C(=O)c4ccccc4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F18 compound treatment 1.15152151E8 -2.54E7 -0.32 1.52425486E8 5820000.0 0.1 -0.1548 -0.464 1602870 TimTec1_003296 CC1CCCCN1S(=O)(=O)c2ccc(cc2)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F19 compound treatment 1.24067297E8 -1.65E7 -0.21 1.15436783E8 -3.12E7 -0.53 -0.5235 -0.9148 1517220 TimTec1_003297 CCC(NS(=O)(=O)c1cc(C)ccc1OC)C2(CC3CC4CC(C3)C2)C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F20 compound treatment 1.09847628E8 -3.07E7 -0.39 1.30661134E8 -1.59E7 -0.27 -0.4653 -0.9858 3083487 TimTec1_003298 Fc1ccc(COc2cccc(/C=C/3\NC(=S)NC3=O)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F21 compound treatment 1.13310151E8 -2.72E7 -0.34 1.59524535E8 1.29E7 0.22 -0.0852 -0.2095 1551647 TimTec1_003299 CCCc1nnc(s1)N(Cc2ccc(Cl)cc2)C(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F22 compound treatment 1.21443541E8 -1.91E7 -0.24 1.79918404E8 3.33E7 0.57 0.2338 0.378 3083489 TimTec1_003300 FC(F)(F)c1nc(SCc2ccccc2)c(C#N)cc1C(=O)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F23 mock treatment 1.07721439E8 -3.28E7 -0.41 1.68021313E8 2.14E7 0.37 -0.032 -0.058 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 F24 mock treatment 1.71961465E8 3.14E7 0.39 1.72558041E8 2.59E7 0.44 0.5928 0.9982 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G01 compound treatment 1.47084835E8 6540000.0 0.08 1.4731497E8 705000.0 0.01 0.0666 0.8025 1314654 TimTec1_003301 COc1ccc(CNC(=O)c2ccc(OC)cc2OC)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G02 compound treatment 1.14497981E8 -2.6E7 -0.33 1.71546846E8 2.49E7 0.43 0.0708 0.1317 1658255 TimTec1_003302 COc1cc(SC)ccc1C(=O)N(C)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G03 compound treatment 1.1950859E8 -2.1E7 -0.26 1.6325864E8 1.66E7 0.28 0.0149 0.0385 1190937 TimTec1_003303 CCOc1ccc(cc1)C(=O)N2CC(C)CC(C)C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G04 compound treatment 1.23180719E8 -1.74E7 -0.22 1.43200019E8 -3410000.0 -0.06 -0.1953 -0.866 3083492 TimTec1_003304 CCCC(C)C(=O)Nc1cccc(Br)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G05 compound treatment 1.08560273E8 -3.2E7 -0.4 1.52307582E8 5700000.0 0.1 -0.2147 -0.5201 3083496 TimTec1_003305 CCNC(=O)c1cccc(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G06 compound treatment 1.05101348E8 -3.54E7 -0.44 1.27386511E8 -1.92E7 -0.33 -0.5471 -0.989 3210423 TimTec1_003306 COc1cc(SC)ccc1C(=O)NCCCn2ccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G07 compound treatment 1.29697844E8 -1.08E7 -0.14 1.76314144E8 2.97E7 0.51 0.2634 0.5003 1444060 TimTec1_003307 CC(=O)Oc1ccccc1C(=O)NCC2CCCO2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G08 compound treatment 1.11246576E8 -2.93E7 -0.37 1.53002257E8 6390000.0 0.11 -0.1825 -0.4759 1696246 TimTec1_003308 CCC(C(=O)Nc1ccc(cc1)S(=O)(=O)N)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G09 compound treatment 1.18230083E8 -2.23E7 -0.28 1.1526061E8 -3.13E7 -0.54 -0.5774 -0.954 1723016 TimTec1_003309 O=C(NCCN1CCOCC1)c2ccccc2Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G10 compound treatment 1.20488739E8 -2.01E7 -0.25 1.59593408E8 1.3E7 0.22 -0.0207 -0.0617 3210424 TimTec1_003310 CN(C)S(=O)(=O)Nc1ccccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G11 compound treatment 1.12651115E8 -2.79E7 -0.35 1.09655891E8 -3.7E7 -0.63 -0.6947 -0.961 1134633 TimTec1_003311 CCN(Cc1ccccc1)C(=O)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G12 compound treatment 1.18333062E8 -2.22E7 -0.28 1.2615077E8 -2.05E7 -0.35 -0.4446 -0.9936 1547792 TimTec1_003312 CCCC(C)C(=O)Nc1ccc(NC(=O)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G13 compound treatment 1.18601885E8 -2.19E7 -0.28 1.06917658E8 -3.97E7 -0.68 -0.6751 -0.9209 3083508 TimTec1_003313 NC(=O)c1ccccc1NC(=O)c2cccc(Br)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G14 compound treatment 1.21448512E8 -1.91E7 -0.24 1.46182749E8 -427000.0 -0.01 -0.1745 -0.7283 1361334 TimTec1_003314 COCC(C)NS(=O)(=O)c1c(C)cc(C)cc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G15 compound treatment 1.20977331E8 -1.96E7 -0.25 1.11243354E8 -3.54E7 -0.61 -0.6016 -0.921 1303565 TimTec1_003315 CC(C)CCNS(=O)(=O)Cc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G16 compound treatment 1.02936496E8 -3.76E7 -0.47 1.12483347E8 -3.41E7 -0.58 -0.7467 -0.9944 1132078 TimTec1_003316 NS(=O)(=O)c1ccc(CCNC(=O)CC(c2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G17 compound treatment 1.08063929E8 -3.25E7 -0.41 1.21198386E8 -2.54E7 -0.43 -0.5957 -0.9995 3084684 TimTec1_003317 Cc1cc(C)cc(NC(=O)Cc2cccs2)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G18 compound treatment 1.06609779E8 -3.39E7 -0.43 1.58432099E8 1.18E7 0.2 -0.1579 -0.335 3084685 TimTec1_003318 CCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G19 compound treatment 1.20842218E8 -1.97E7 -0.25 1.1453822E8 -3.21E7 -0.55 -0.5629 -0.935 1406144 TimTec1_003319 CC(Oc1ccccc1)C(=O)NC2CCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G20 compound treatment 1.12624105E8 -2.79E7 -0.35 1.18839419E8 -2.78E7 -0.48 -0.5838 -0.9887 3210425 TimTec1_003320 Cc1ccc(cc1)c2nc3sc4nc5ccccc5nc4n3n2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G21 compound treatment 1.06913326E8 -3.36E7 -0.42 1.19381383E8 -2.72E7 -0.47 -0.6279 -0.9988 1483366 TimTec1_003321 CCCC(C)C(=O)NCc1ccccc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G22 compound treatment 1.2876861E8 -1.18E7 -0.15 1.22414447E8 -2.42E7 -0.41 -0.3973 -0.9035 1622726 TimTec1_003322 O=C(NCCc1nc2ccccc2[nH]1)C3COc4ccccc4O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G23 mock treatment 1.20932676E8 -1.96E7 -0.25 1.10931999E8 -3.57E7 -0.61 -0.6058 -0.9201 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 G24 mock treatment 1.76581974E8 3.6E7 0.45 1.63925203E8 1.73E7 0.3 0.5293 0.979 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H01 compound treatment 1.47694203E8 7150000.0 0.09 1.65854109E8 1.92E7 0.33 0.2964 0.8681 3084686 TimTec1_003323 FC(F)(F)c1ccc(COc2ccc3cc(c4ccccn4)c(=O)oc3c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H02 compound treatment 1.04311009E8 -3.62E7 -0.45 1.32667618E8 -1.39E7 -0.24 -0.4901 -0.9548 1383752 TimTec1_003324 OC1(CC(=O)C2CC3CC2C=C3)C(=O)Nc4ccccc41 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H03 compound treatment 1.14124273E8 -2.64E7 -0.33 1.48787125E8 2180000.0 0.04 -0.208 -0.6237 3084687 TimTec1_003325 CCOC(=O)c1cc(C(=O)OCC)n(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H04 compound treatment 1.31735836E8 -8810000.0 -0.11 1.48984055E8 2370000.0 0.04 -0.0494 -0.4195 3210426 TimTec1_003326 Cc1ccccc1n2c(CSC(=N)N)nc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H05 compound treatment 1.35852413E8 -4690000.0 -0.06 1.31493693E8 -1.51E7 -0.26 -0.2246 -0.8463 3084688 TimTec1_003327 O=C(N/C=N/C(=O)c1cccnc1)c2cccnc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H06 compound treatment 9.9180102E7 -4.14E7 -0.52 1.05842429E8 -4.08E7 -0.7 -0.8604 -0.9894 1564884 TimTec1_003328 CN1CCN(CC1)S(=O)(=O)c2cccc3cccnc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H07 compound treatment 1.12866925E8 -2.77E7 -0.35 1.57908774E8 1.13E7 0.19 -0.1087 -0.2736 3210427 TimTec1_003329 Cc1ccc(cc1)n2c(SCC(=O)C(C)(C)C)nnc2c3ccncc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H08 compound treatment 9.5080913E7 -4.55E7 -0.57 1.50535539E8 3930000.0 0.07 -0.3557 -0.6195 3084689 TimTec1_003330 Nc1nc(SCC#N)c(C#N)c(c1C#N)c2cccc(F)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H09 compound treatment 1.30509916E8 -1.0E7 -0.13 1.60181693E8 1.36E7 0.23 0.0753 0.2849 3210428 TimTec1_003331 CCC(=O)NC(Nc1sc2CCCc2c1C(=O)OC)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H10 compound treatment 1.03424862E8 -3.71E7 -0.47 1.59185502E8 1.26E7 0.22 -0.177 -0.3451 3084690 TimTec1_003332 Cc1noc(c1I)c2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H11 compound treatment 1.30003814E8 -1.05E7 -0.13 1.65499606E8 1.89E7 0.32 0.1352 0.3869 3084691 TimTec1_003333 NC1=C(C#N)C(NN1c2ccccc2)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H12 compound treatment 1.33632577E8 -6910000.0 -0.09 1.54639554E8 8030000.0 0.14 0.0359 0.2209 1616513 TimTec1_003334 Ic1ccc(NC(=O)CC2CCOCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H13 compound treatment 1.08835094E8 -3.17E7 -0.4 1.37216685E8 -9390000.0 -0.16 -0.395 -0.9206 3210429 TimTec1_003335 Cc1cc(C)c(C#N)c(SCSc2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H14 compound treatment 1.0142686E8 -3.91E7 -0.49 1.36819805E8 -9790000.0 -0.17 -0.4655 -0.8977 3084692 TimTec1_003336 Cn1nnnc1SCC(=O)Nc2nccs2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H15 compound treatment 1.33763386E8 -6780000.0 -0.09 1.38798897E8 -7810000.0 -0.13 -0.1547 -0.9761 3210430 TimTec1_003337 Cc1ccc(cc1)C(=O)OCC2OC(O)C(O)C2OC(=O)c3ccc(C)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H16 compound treatment 1.04408158E8 -3.61E7 -0.45 1.56530159E8 9920000.0 0.17 -0.2004 -0.4141 1327025 TimTec1_003338 CC1C2CC(CC1(C)C)N(C2)C(=O)c3ccc(cc3)N4C(=O)c5ccccc5C4=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H17 compound treatment 1.05016303E8 -3.55E7 -0.45 1.39347063E8 -7260000.0 -0.12 -0.403 -0.8711 3084693 TimTec1_003339 COc1ccc2nc(N3CCCCC3)c(/C=C/4\N=C(OC4=O)c5ccccc5)cc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H18 compound treatment 1.32238282E8 -8300000.0 -0.1 1.3530238E8 -1.13E7 -0.19 -0.2105 -0.9578 3210431 TimTec1_003340 O=c1[nH]c(CN2CCCCC2)nc3c4ccccc4oc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H19 compound treatment 1.03655673E8 -3.69E7 -0.46 1.00197518E8 -4.64E7 -0.79 -0.889 -0.9669 1074832 TimTec1_003341 OC(=O)CCN1CCCc2ccccc12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H20 compound treatment 1.20018311E8 -2.05E7 -0.26 1.38743916E8 -7870000.0 -0.13 -0.2773 -0.9543 3210432 TimTec1_003342 O=C1CC(S/C(=N/c2ccccc2)/Nc3ccccc3)C(=O)N1CCc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H21 compound treatment 1.19101812E8 -2.14E7 -0.27 1.59543172E8 1.29E7 0.22 -0.0336 -0.0966 3084694 TimTec1_003343 COC(=O)C(CC(=O)c1ccc(Br)cc1)(Cc2ccc(Br)cc2)C(=O)OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H22 compound treatment 1.501128E8 9570000.0 0.12 1.17918347E8 -2.87E7 -0.49 -0.2624 -0.519 3210433 TimTec1_003344 CC/C(=C\C(=O)c1ccc(Br)cc1)/O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H23 mock treatment 1.50448826E8 9910000.0 0.12 1.1595475E8 -3.07E7 -0.52 -0.2832 -0.5251 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 H24 mock treatment 1.63077752E8 2.25E7 0.28 1.67997467E8 2.14E7 0.37 0.4588 0.9918 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I01 compound treatment 1.62922006E8 2.24E7 0.28 1.49053399E8 2440000.0 0.04 0.2281 0.8036 1172830 TimTec1_003345 COc1ccc(cc1OC)C(=O)N2CCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I02 compound treatment 1.62751447E8 2.22E7 0.28 1.57633152E8 1.1E7 0.19 0.3304 0.982 3210434 TimTec1_003346 CCN(CC)C(=O)Cc1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I03 compound treatment 1.64455347E8 2.39E7 0.3 1.54331615E8 7720000.0 0.13 0.3056 0.9322 1474996 TimTec1_003347 CCOc1ccccc1NC(=O)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I04 compound treatment 1.59048637E8 1.85E7 0.23 1.76762101E8 3.02E7 0.52 0.5291 0.9349 1142378 TimTec1_003348 COc1ccc(CNS(=O)(=O)N(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I05 compound treatment 1.66405171E8 2.59E7 0.32 1.56444036E8 9830000.0 0.17 0.3484 0.9533 3210550 TimTec1_003349 COc1cccc(c1)C(=O)N2CCCCC2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I06 compound treatment 1.74815716E8 3.43E7 0.43 1.57093627E8 1.05E7 0.18 0.4309 0.9249 1492690 TimTec1_003350 COc1ccccc1NC(=O)Cc2ccc(Br)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I07 compound treatment 1.66052479E8 2.55E7 0.32 1.65640516E8 1.9E7 0.33 0.4566 1.0 3210551 TimTec1_003351 CN(C)C(=O)c1ccccc1OC(=O)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I08 compound treatment 1.79216636E8 3.87E7 0.49 1.68931106E8 2.23E7 0.38 0.6132 0.993 3084695 TimTec1_003352 O=C(Cc1cccs1)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I09 compound treatment 1.776267E8 3.71E7 0.47 1.61940523E8 1.53E7 0.26 0.5145 0.9633 1220667 TimTec1_003353 COC(=O)c1ccccc1NC(=O)c2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I10 compound treatment 1.97617053E8 5.71E7 0.72 1.7406764E8 2.75E7 0.47 0.8386 0.9792 3084696 TimTec1_003354 CCN(C1CCCCC1)C(=O)CC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I11 compound treatment 1.89476265E8 4.89E7 0.61 1.79987776E8 3.34E7 0.57 0.8381 0.9994 1615201 TimTec1_003355 CCCCC(CC)C(=O)Nc1cc(OC)ccc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I12 compound treatment 1.91950232E8 5.14E7 0.64 1.60668608E8 1.41E7 0.24 0.6262 0.9097 1644031 TimTec1_003356 CCCC(C)C(=O)NCc1ccncc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I13 compound treatment 1.83013541E8 4.25E7 0.53 1.665543E8 1.99E7 0.34 0.6181 0.9769 1727106 TimTec1_003357 NC(=O)c1ccccc1NC(=O)CC(c2ccccc2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I14 compound treatment 2.0585893E8 6.53E7 0.82 1.89605258E8 4.3E7 0.74 1.0998 0.9986 1241961 TimTec1_003358 COCC(C)NS(=O)(=O)c1ccc(F)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I15 compound treatment 1.81499802E8 4.1E7 0.51 1.7172522E8 2.51E7 0.43 0.6673 0.9961 3210552 TimTec1_003359 CC(C)(C)NC(=O)Cc1ccc(Br)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I16 compound treatment 1.64759264E8 2.42E7 0.3 1.77452457E8 3.08E7 0.53 0.5881 0.9655 1125244 TimTec1_003360 CCC(CC)NC(=O)c1ccc2OCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I17 compound treatment 1.63959945E8 2.34E7 0.29 1.67253457E8 2.06E7 0.35 0.4576 0.9958 3084697 TimTec1_003361 CCC(C)(C)C(=O)Nc1cc(C)cc(C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I18 compound treatment 1.6882628E8 2.83E7 0.35 1.82624466E8 3.6E7 0.62 0.6868 0.9656 1302744 TimTec1_003362 CCC(C)(C)C(=O)NCc1ccc2OCOc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I19 compound treatment 1.78829105E8 3.83E7 0.48 1.76964649E8 3.04E7 0.52 0.707 0.9992 3084700 TimTec1_003363 Brc1ccc(CC(=O)Nc2nccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I20 compound treatment 1.60540636E8 2.0E7 0.25 1.52479061E8 5870000.0 0.1 0.2484 0.9193 3210553 TimTec1_003364 Cc1nn(c2OC(=C(C#N)C(c12)(C(F)(F)F)C(F)(F)F)N)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I21 compound treatment 1.4705691E8 6510000.0 0.08 1.75563793E8 2.9E7 0.5 0.4083 0.8127 1183466 TimTec1_003365 COc1ccccc1CNC(=O)C(C)Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I22 compound treatment 1.80556645E8 4.0E7 0.5 1.52506895E8 5900000.0 0.1 0.4263 0.8326 1258450 TimTec1_003366 O=C1CS(=O)(=O)C(N1c2ccccc2)c3ccc(Oc4ccccc4)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I23 mock treatment 1.80395917E8 3.99E7 0.5 1.63796459E8 1.72E7 0.29 0.5615 0.968 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 I24 mock treatment 1.79001753E8 3.85E7 0.48 1.44428725E8 -2180000.0 -0.04 0.3147 0.6504 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J01 compound treatment 1.60501707E8 2.0E7 0.25 1.62460389E8 1.59E7 0.27 0.3689 0.9992 1010972 TimTec1_003367 C(Cc1ccccn1)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J02 compound treatment 1.97449562E8 5.69E7 0.71 2.10256446E8 6.36E7 1.09 1.2752 0.979 1550058 TimTec1_003368 CC1(OC(=N)C2(C#N)C1c3ccccc3)OC(c4ccccc4)C2(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J03 compound treatment 1.45800901E8 5260000.0 0.07 1.72016347E8 2.54E7 0.43 0.3542 0.8051 3084706 TimTec1_003369 OC(=O)c1ccn(COc2ccccc2)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J04 compound treatment 1.69610201E8 2.91E7 0.36 1.99208165E8 5.26E7 0.9 0.8945 0.9208 1414868 TimTec1_003370 Oc1c(oc2ccccc2c1=O)c3ccc(F)c(Oc4ccccc4)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J05 compound treatment 1.53562964E8 1.3E7 0.16 1.84831605E8 3.82E7 0.65 0.5781 0.8573 3084708 TimTec1_003371 Cc1nnc(o1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J06 compound treatment 1.45503269E8 4960000.0 0.06 1.74004215E8 2.74E7 0.47 0.3756 0.794 1397012 TimTec1_003372 OC(=O)c1cn(C2CC2)c3cc(N4CCN(CC4)C(=S)S)c(F)cc3c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J07 compound treatment 1.47592395E8 7050000.0 0.09 1.80467793E8 3.39E7 0.58 0.4724 0.8057 1297192 TimTec1_003373 CCOc1ccc(cc1)n2c(SCC(=O)N)nc3ccccc3c2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J08 compound treatment 1.2075005E8 -1.98E7 -0.25 1.5094936E8 4340000.0 0.07 -0.123 -0.4748 3210554 TimTec1_003374 Cc1ccc(Cl)cc1NCN2C(=O)/C(=C/c3ccc(Br)cc3)/NC2=S 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J09 compound treatment 1.69586996E8 2.9E7 0.36 1.65894719E8 1.93E7 0.33 0.4911 0.9988 1683010 TimTec1_003375 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)Nc4ncccc4C)c2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J10 compound treatment 1.56343797E8 1.58E7 0.2 1.74141236E8 2.75E7 0.47 0.4734 0.9259 1172443 TimTec1_003376 Oc1c(Br)cc(Br)cc1C(=O)CSC(=S)N2CCOCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J11 compound treatment 1.94567781E8 5.4E7 0.68 1.93446547E8 4.68E7 0.8 1.0461 0.9965 3210555 TimTec1_003377 CCn1c(NC(=O)COc2cccc(c2)C(F)(F)F)nc3ccccc13 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J12 compound treatment 1.45877067E8 5330000.0 0.07 1.31995463E8 -1.46E7 -0.25 -0.1296 -0.5004 3084740 TimTec1_003378 CC1CN(C)C(C)/C(=C\c2ccco2)/C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J13 compound treatment 1.65180751E8 2.46E7 0.31 2.01124811E8 5.45E7 0.93 0.8784 0.8936 1131053 TimTec1_003379 Cc1ccc(cc1)c2nc3ccc(NCc4cccs4)cc3o2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J14 compound treatment 1.86207472E8 4.57E7 0.57 1.76323907E8 2.97E7 0.51 0.7647 0.9982 3210556 TimTec1_003380 COc1ccc(cc1)C(=O)CSc2nn3c(SCC(=O)c4ccc(OC)cc4)nnc3s2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J15 compound treatment 1.61767244E8 2.12E7 0.27 1.78725532E8 3.21E7 0.55 0.577 0.9446 1251084 TimTec1_003381 C1Cc2cn(cc2CCc3cn(cc13)c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J16 compound treatment 1.67162878E8 2.66E7 0.33 1.72052893E8 2.54E7 0.44 0.5441 0.9914 1180362 TimTec1_003382 O=C(CSC1=NCCS1)Nc2nc(cs2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J17 compound treatment 1.75046449E8 3.45E7 0.43 1.74238862E8 2.76E7 0.47 0.6405 0.999 1305573 TimTec1_003383 CCCc1c(C)nc2c(C)cccc2c1SCCC(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J18 compound treatment 1.66385316E8 2.58E7 0.32 1.79980983E8 3.34E7 0.57 0.6332 0.964 1123163 TimTec1_003384 CCN(CC)S(=O)(=O)c1ccc(Cl)c(c1)C(=O)N2c3ccccc3Sc4ccccc24 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J19 compound treatment 1.70668431E8 3.01E7 0.38 1.72946903E8 2.63E7 0.45 0.586 0.9962 1426086 TimTec1_003385 OC(CSc1ncnc2[nH]cnc12)c3ccc(Cl)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J20 compound treatment 1.11281368E8 -2.93E7 -0.37 1.05139893E8 -4.15E7 -0.71 -0.7615 -0.9529 3210557 TimTec1_003386 NC(=O)/C(=C/1\C(=O)Nc2ccc(Br)cc12)/C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J21 compound treatment 1.84620631E8 4.41E7 0.55 1.86408712E8 3.98E7 0.68 0.8727 0.9946 3084745 TimTec1_003387 Oc1c(ccc2cccnc12)C(O)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J22 compound treatment 1.80120117E8 3.96E7 0.5 1.47543658E8 934000.0 0.02 0.3624 0.7295 1595988 TimTec1_003388 CCOC(=O)c1[nH]c(=O)[nH]c1COC(=O)CNC(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J23 mock treatment 1.2886109E8 -1.17E7 -0.15 1.67902674E8 2.13E7 0.36 0.1541 0.3923 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 J24 mock treatment 1.91450633E8 5.09E7 0.64 1.48778841E8 2170000.0 0.04 0.4778 0.747 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K01 compound treatment 1.43082686E8 2540000.0 0.03 1.38353531E8 -8260000.0 -0.14 -0.0774 -0.5343 1244666 TimTec1_003389 COc1ccc(cc1OC)C(=O)N2CCC(Cc3ccccc3)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K02 compound treatment 1.20972711E8 -1.96E7 -0.25 1.68953813E8 2.23E7 0.38 0.0969 0.2131 3210558 TimTec1_003390 CCN(CC)C(=O)Cc1cccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K03 compound treatment 1.704939E8 3.0E7 0.38 1.32392341E8 -1.42E7 -0.24 0.0936 0.2091 1215547 TimTec1_003391 O=C(N(CC#N)CC#N)c1ccco1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K04 compound treatment 1.6562851E8 2.51E7 0.31 1.35233589E8 -1.14E7 -0.19 0.0848 0.2292 3210559 TimTec1_003392 CCc1ccccc1NC(=O)C(C)(C)CC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K05 compound treatment 1.1292722E8 -2.76E7 -0.35 1.71223356E8 2.46E7 0.42 0.053 0.0971 1650684 TimTec1_003393 O=C(NCC#N)c1ccc(cc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K06 compound treatment 1.31311345E8 -9230000.0 -0.12 1.67953346E8 2.13E7 0.37 0.1765 0.4604 3210560 TimTec1_003394 CC1CN(CC(C)O1)C(=O)Cc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K07 compound treatment 1.21847391E8 -1.87E7 -0.23 1.43090265E8 -3520000.0 -0.06 -0.2084 -0.8608 3084750 TimTec1_003395 CNC(=O)c1ccc(cc1)C(C)(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K08 compound treatment 1.74677839E8 3.41E7 0.43 1.71596786E8 2.5E7 0.43 0.6052 1.0 3210561 TimTec1_003396 CCc1ccc(NC(=O)Cc2cccs2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K09 compound treatment 1.76344015E8 3.58E7 0.45 1.50505186E8 3900000.0 0.07 0.3647 0.8033 1267949 TimTec1_003397 CC(NC(=O)c1ccc2OCOc2c1)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K10 compound treatment 1.3221521E8 -8330000.0 -0.1 1.34190069E8 -1.24E7 -0.21 -0.2242 -0.9465 3084752 TimTec1_003398 CC(C)CC(=O)Nc1ccccc1C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K11 compound treatment 1.26472998E8 -1.41E7 -0.18 1.77017799E8 3.04E7 0.52 0.2433 0.4426 1245827 TimTec1_003399 CCOc1ccccc1C(=O)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K12 compound treatment 1.36940941E8 -3600000.0 -0.05 1.69451464E8 2.28E7 0.39 0.2445 0.6213 1351900 TimTec1_003400 CC(Oc1ccccc1)C(=O)N2CCCc3ccccc23 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K13 compound treatment 1.09301689E8 -3.12E7 -0.39 1.58191067E8 1.16E7 0.2 -0.1369 -0.3118 1440169 TimTec1_003401 CC(=O)Oc1ccccc1C(=O)Nc2ccc(cc2)C(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K14 compound treatment 1.44048608E8 3510000.0 0.04 1.81714867E8 3.51E7 0.6 0.456 0.7568 1291221 TimTec1_003402 CCOC(=O)C1CCCN(C1)C(=O)c2ccc(F)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K15 compound treatment 1.41742497E8 1200000.0 0.02 1.53662669E8 7050000.0 0.12 0.096 0.7892 1346285 TimTec1_003403 O=C(Cc1cccs1)N2CCN(CC2)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K16 compound treatment 1.21716876E8 -1.88E7 -0.24 1.91201802E8 4.46E7 0.76 0.3728 0.4665 1313407 TimTec1_003404 CCOC(=O)C1CCCN(C1)C(=O)c2ccccc2OCC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K17 compound treatment 1.36559932E8 -3980000.0 -0.05 1.9558982E8 4.9E7 0.84 0.5575 0.6638 1513214 TimTec1_003405 CC(Oc1ccccc1)C(=O)Nc2cc(C)cc(C)c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K18 compound treatment 1.39171578E8 -1370000.0 -0.02 1.7491978E8 2.83E7 0.48 0.3305 0.6816 1270183 TimTec1_003406 CC(Oc1ccccc1)C(=O)NCCc2ccc(cc2)S(=O)(=O)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K19 compound treatment 1.26301331E8 -1.42E7 -0.18 1.25462511E8 -2.11E7 -0.36 -0.3823 -0.947 3084799 TimTec1_003407 CCC(C)C(=O)Nc1nccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K20 compound treatment 1.22792223E8 -1.78E7 -0.22 1.64663838E8 1.81E7 0.31 0.0611 0.1604 1161699 TimTec1_003408 Cc1ccc(cc1)C2SCC(N2C(=O)c3cccc(Cl)c3)C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K21 compound treatment 1.37783769E8 -2760000.0 -0.03 1.80927366E8 3.43E7 0.59 0.3909 0.6643 1190170 TimTec1_003409 CCN(Cc1ccccc1)C(=O)C(C)Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K22 compound treatment 1.67969733E8 2.74E7 0.34 1.46576653E8 -33200.0 0.0 0.2429 0.7059 3210685 TimTec1_003410 CC1(CC(=NC(=N1)SCC(=O)O)n2c3ccccc3c4ccccc24)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K23 mock treatment 1.1580356E8 -2.47E7 -0.31 1.12715445E8 -3.39E7 -0.58 -0.6297 -0.957 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 K24 mock treatment 1.68078009E8 2.75E7 0.35 1.56656659E8 1.0E7 0.17 0.3659 0.9481 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L01 compound treatment 1.14125146E8 -2.64E7 -0.33 1.63389387E8 1.68E7 0.29 -0.0312 -0.0712 3084803 TimTec1_003411 CC(C)Cc1ccc(/C=C/C(=O)N2CCOCC2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L02 compound treatment 1.30755976E8 -9790000.0 -0.12 1.54825331E8 8220000.0 0.14 0.0126 0.0677 3210686 TimTec1_003412 OC(=O)C1CC(=O)N(CCC2(CC3CC4CC(C3)C2)C4)/C(=N\c5ccc(Cl)cc5)/S1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L03 compound treatment 1.14332314E8 -2.62E7 -0.33 1.57110994E8 1.05E7 0.18 -0.1054 -0.2812 3084804 TimTec1_003413 COC(=O)c1ccn(COc2ccccc2Cl)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L04 compound treatment 1.48811732E8 8270000.0 0.1 1.6693964E8 2.03E7 0.35 0.3194 0.8796 1272311 TimTec1_003414 COc1ccc(NC(=O)C2(CCCCC2)N(Cc3ccccc3)C(=O)Cc4nc(N)n[nH]4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L05 compound treatment 1.16517349E8 -2.4E7 -0.3 1.43379009E8 -3230000.0 -0.06 -0.2522 -0.8231 1572389 TimTec1_003415 COC(=O)c1ccc(cc1)N2C(SC(C)C2=O)c3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L06 compound treatment 1.11913617E8 -2.86E7 -0.36 1.49868646E8 3260000.0 0.06 -0.2145 -0.5902 3210687 TimTec1_003416 Fc1ccc(NC(=O)c2cccc(OC(=S)Nc3cccc(Br)c3)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L07 compound treatment 1.09472186E8 -3.11E7 -0.39 1.55605097E8 9000000.0 0.15 -0.1667 -0.3978 3084807 TimTec1_003417 CCOc1ccc(cc1)n2c(SCc3ccccc3)nnc2c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L08 compound treatment 1.47178993E8 6640000.0 0.08 1.53959851E8 7350000.0 0.13 0.1478 0.9799 3210688 TimTec1_003418 CC(C)(C)Cc1ccc(OCCCC(=O)O)c(CC(C)(C)C)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L09 compound treatment 1.14209206E8 -2.63E7 -0.33 1.27557146E8 -1.91E7 -0.33 -0.4642 -1.0 3210689 TimTec1_003419 Nc1c(sc2nc(cc(c12)C(F)(F)F)c3cccs3)S(=O)(=O)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L10 compound treatment 1.2309223E8 -1.75E7 -0.22 1.76945075E8 3.03E7 0.52 0.2124 0.3769 3084809 TimTec1_003420 CCN/C(=N\CC)/SC1CC(=O)N(CCc2ccccc2)C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L11 compound treatment 1.19031182E8 -2.15E7 -0.27 1.40298816E8 -6310000.0 -0.11 -0.2672 -0.9193 3210690 TimTec1_003421 CCC(N/C(=N/c1ccccc1C(=O)OC)/O)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L12 compound treatment 1.77842803E8 3.73E7 0.47 1.66067648E8 1.95E7 0.33 0.5664 0.9861 3084811 TimTec1_003422 N#Cc1ccc(nc1SCCOc2ccccc2)c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L13 compound treatment 1.14162018E8 -2.64E7 -0.33 1.70601252E8 2.4E7 0.41 0.0564 0.1069 1139626 TimTec1_003423 CC(Oc1ccc(Cl)c(C)c1)c2nc(no2)c3nonc3N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L14 compound treatment 1.37429641E8 -3110000.0 -0.04 1.41908176E8 -4700000.0 -0.08 -0.0845 -0.9448 3084813 TimTec1_003424 CC(C)CSc1nc(NC(=O)C)n[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L15 compound treatment 1.12419039E8 -2.81E7 -0.35 1.63046568E8 1.64E7 0.28 -0.0505 -0.1119 3210691 TimTec1_003425 CC1=NC2=NN=C(NC(=O)Nc3ccc(Cl)c(Cl)c3)C2C(=C1)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L16 compound treatment 7.1156369E7 -6.94E7 -0.87 9.3116924E7 -5.35E7 -0.92 -1.263 -0.9997 3084815 TimTec1_003426 OC1(CCCCC1)C(=O)/C=C/c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L17 compound treatment 1.64840209E8 2.43E7 0.3 1.23874106E8 -2.27E7 -0.39 -0.0597 -0.1207 3210692 TimTec1_003427 CCOC(=O)c1ccc(NC(=S)NCCOC2(CC3CC4CC(C3)C2)C4)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L18 compound treatment 1.2622236E8 -1.43E7 -0.18 1.74580326E8 2.8E7 0.48 0.2115 0.4137 1179986 TimTec1_003428 CCOC(=O)CSc1nc2ccccc2n1C(=O)Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L19 compound treatment 1.29641936E8 -1.09E7 -0.14 1.38064493E8 -8550000.0 -0.15 -0.2001 -0.9994 3084845 TimTec1_003429 Oc1cc(n[nH]1)c2ccc3ccccc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L20 compound treatment 1.128629E8 -2.77E7 -0.35 1.16870158E8 -2.97E7 -0.51 -0.6055 -0.9826 3210693 TimTec1_003430 CCC(=O)NC(c1c(C)nn(c1O)c2ccccc2)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L21 compound treatment 1.20704715E8 -1.98E7 -0.25 1.82482296E8 3.59E7 0.61 0.2582 0.3898 1146641 TimTec1_003431 CC1(C)CC(CCNC(=O)c2ccccc2C(=O)O)(Cc3ccccc3)CCO1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L22 compound treatment 1.53902766E8 1.34E7 0.17 1.63332419E8 1.67E7 0.29 0.3209 0.9675 1486235 TimTec1_003432 CCCC1C(c2ccccc2)C3(C#N)C(=O)NC1(O)CC3(C#N)C#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L23 mock treatment 1.59872422E8 1.93E7 0.24 1.20462547E8 -2.61E7 -0.45 -0.145 -0.2849 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 L24 mock treatment 1.65004681E8 2.45E7 0.31 1.46895022E8 285000.0 0.0 0.2204 0.7183 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M01 compound treatment 1.41734488E8 1190000.0 0.01 1.5191297E8 5300000.0 0.09 0.0748 0.8126 1722217 TimTec1_003433 CCCN(CCC)C(=O)c1cc(OC)cc(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M02 compound treatment 1.22483629E8 -1.81E7 -0.23 1.71003033E8 2.44E7 0.42 0.1351 0.2843 1254098 TimTec1_003434 O=C(CN1C(=O)c2ccccc2C1=O)N3CCN(Cc4ccccc4)CC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M03 compound treatment 1.51756962E8 1.12E7 0.14 1.72421222E8 2.58E7 0.44 0.4119 0.8883 3084849 TimTec1_003435 CC1CC(C)CN(C1)C(=O)c2ccco2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M04 compound treatment 1.12839081E8 -2.77E7 -0.35 1.87681677E8 4.11E7 0.7 0.2514 0.3206 1397116 TimTec1_003436 CCc1ccccc1NC(=O)C(C)Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M05 compound treatment 1.53808253E8 1.33E7 0.17 1.70409071E8 2.38E7 0.41 0.4057 0.922 3084851 TimTec1_003437 CC(C)NC(=O)c1ccc(cc1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M06 compound treatment 9.8657637E7 -4.19E7 -0.53 1.69652573E8 2.3E7 0.39 -0.0926 -0.141 3210694 TimTec1_003438 CCCC(C)NC(=O)Cc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M07 compound treatment 1.6624307E8 2.57E7 0.32 2.10098535E8 6.35E7 1.09 0.9965 0.879 1130565 TimTec1_003439 COc1ccc(CC(=O)N2CCCCCC2)cc1OC 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M08 compound treatment 1.16292056E8 -2.43E7 -0.3 1.63383588E8 1.68E7 0.29 -0.0121 -0.0289 3084854 TimTec1_003440 CC(C)CCNC(=O)Cc1cccs1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M09 compound treatment 1.54590448E8 1.4E7 0.18 1.676731E8 2.11E7 0.36 0.3796 0.9458 1411902 TimTec1_003441 CC1CC(C)CN(C1)C(=O)c2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M10 compound treatment 1.41281148E8 739000.0 0.01 1.53614682E8 7000000.0 0.12 0.0913 0.7595 1680018 TimTec1_003442 COc1cc(SC)ccc1C(=O)N(C)Cc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M11 compound treatment 1.58449993E8 1.79E7 0.22 1.61621506E8 1.5E7 0.26 0.3406 0.9978 1446751 TimTec1_003443 CCOc1ccccc1C(=O)NC2CCCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M12 compound treatment 1.57121387E8 1.66E7 0.21 1.60925244E8 1.43E7 0.25 0.3203 0.9967 1204191 TimTec1_003444 CC1CC(C)CN(C1)C(=O)COc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M13 compound treatment 1.35676428E8 -4870000.0 -0.06 1.55658908E8 9050000.0 0.15 0.0664 0.3986 1194660 TimTec1_003445 NS(=O)(=O)c1ccc(CNC(=O)c2ccccc2Oc3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M14 compound treatment 1.54425621E8 1.39E7 0.17 1.65794315E8 1.92E7 0.33 0.3554 0.956 3084858 TimTec1_003446 COCC(C)NC(=O)c1ccco1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M15 compound treatment 1.37146953E8 -3400000.0 -0.04 1.88913906E8 4.23E7 0.72 0.4819 0.6644 1365776 TimTec1_003447 CN(C)S(=O)(=O)N1CCN(CC1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M16 compound treatment 1.72634028E8 3.21E7 0.4 1.6762582E8 2.1E7 0.36 0.539 0.9984 1365264 TimTec1_003448 CCOc1ccccc1C(=O)NCc2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M17 compound treatment 1.49573914E8 9030000.0 0.11 1.6568415E8 1.91E7 0.33 0.311 0.8998 3084861 TimTec1_003449 CCC(C)C(=O)Nc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M18 compound treatment 1.72139399E8 3.16E7 0.4 1.76365078E8 2.98E7 0.51 0.6404 0.9923 1138474 TimTec1_003450 CCC(CC)NC(=O)C(C)Oc1ccccc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M19 compound treatment 1.57550699E8 1.7E7 0.21 1.82253234E8 3.56E7 0.61 0.5823 0.9009 1334117 TimTec1_003451 CN(C)S(=O)(=O)N1CCC(Cc2ccccc2)CC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M20 compound treatment 1.80823054E8 4.03E7 0.51 1.60964988E8 1.44E7 0.25 0.5311 0.9451 1691322 TimTec1_003452 Cc1c(sc2nc[nH]c(=O)c12)C(=O)N3CCCCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M21 compound treatment 9.7652953E7 -4.29E7 -0.54 1.89941156E8 4.33E7 0.74 0.144 0.1572 1214562 TimTec1_003453 CCOc1ccc(NS(=O)(=O)N(C)C)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M22 compound treatment 1.02873436E8 -3.77E7 -0.47 1.52033527E8 5420000.0 0.09 -0.2685 -0.5575 3084924 TimTec1_003454 OCc1occ(O)c(=O)c1C(Nc2ccccn2)c3ccccc3O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M23 mock treatment 1.48509323E8 7970000.0 0.1 1.71269607E8 2.47E7 0.42 0.3692 0.851 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 M24 mock treatment 1.60314027E8 1.98E7 0.25 1.71842283E8 2.52E7 0.43 0.4808 0.9653 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N01 compound treatment 1.58697268E8 1.82E7 0.23 1.52426512E8 5820000.0 0.1 0.2314 0.9312 1273050 TimTec1_003455 Nc1ccccc1C(=O)c2ccccc2C(=O)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N02 compound treatment 1.51408911E8 1.09E7 0.14 1.57693155E8 1.11E7 0.19 0.2305 0.9868 1558367 TimTec1_003456 O=c1[nH]c(=S)c2CCCc2n1Cc3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N03 compound treatment 1.9653819E8 5.6E7 0.7 1.72607575E8 2.6E7 0.45 0.8114 0.9757 3210695 TimTec1_003457 CCOC(=O)CC(=O)c1ccn(C)n1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N04 compound treatment 1.29272352E8 -1.13E7 -0.14 1.76752966E8 3.01E7 0.52 0.2649 0.4951 1599603 TimTec1_003458 O=C1N(CCc2cn3cccnc3n2)C(=O)c4ccccc14 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N05 compound treatment 1.20410065E8 -2.01E7 -0.25 1.68100174E8 2.15E7 0.37 0.0815 0.1827 3084928 TimTec1_003459 Cc1cc(N/C=N/c2ccc(Br)c(C)c2)ccc1Br 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N06 compound treatment 1.78860178E8 3.83E7 0.48 1.72961445E8 2.64E7 0.45 0.6589 0.9995 3210696 TimTec1_003460 O=C1CCC(=O)N1[C@H]2CC(=O)[C@@H]3OCC2O3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N07 compound treatment 1.60290999E8 1.97E7 0.25 1.49840642E8 3230000.0 0.06 0.2143 0.8442 3084930 TimTec1_003461 C/C(=C\c1ccco1)/C=N/n2c(S)nnc2COc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N08 compound treatment 2.08481053E8 6.79E7 0.85 1.78675723E8 3.21E7 0.55 0.9908 0.9774 3210697 TimTec1_003462 CC(C)c1ccc2c(c1)c3CCCc4cncn2c34 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N09 compound treatment 1.97978985E8 5.74E7 0.72 1.66888205E8 2.03E7 0.35 0.7549 0.9439 3210698 TimTec1_003463 CCc1nnc(SCC(=O)Nc2cc(C)on2)[nH]1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N10 compound treatment 1.8590607E8 4.54E7 0.57 1.76354506E8 2.97E7 0.51 0.7624 0.9985 3084933 TimTec1_003464 Brc1ccc(cc1)C(=O)CSc2ncnn2CC(=O)c3ccc(Br)cc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N11 compound treatment 1.96937128E8 5.64E7 0.71 1.62128773E8 1.55E7 0.27 0.6881 0.9106 3210816 TimTec1_003465 CCC(=O)NC(Nc1c(C)n(C)n(c2ccccc2)c1=O)(C(F)(F)F)C(F)(F)F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N12 compound treatment 1.8241079E8 4.19E7 0.53 1.58289628E8 1.17E7 0.2 0.5128 0.9124 1413545 TimTec1_003466 O=C(NC(Cc1ccccc1)C(=O)Nc2nc(cs2)c3ccccc3)Oc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N13 compound treatment 1.10384063E8 -3.02E7 -0.38 1.47891497E8 1280000.0 0.02 -0.252 -0.665 1677156 TimTec1_003467 Cc1ccccc1C(=O)c2ccc3n(C)c(=O)n(C)c3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N14 compound treatment 1.70343895E8 2.98E7 0.37 1.62984543E8 1.64E7 0.28 0.4626 0.9899 3210817 TimTec1_003468 COc1ccc(CN/C(=N\c2ccccc2)/SC3CC(=O)N(C)C3=O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N15 compound treatment 1.6346481E8 2.29E7 0.29 1.49363889E8 2750000.0 0.05 0.2367 0.8122 3084935 TimTec1_003469 CC1(CCCCC12)N=C(c3ccccc3)C42C=CC(=O)C=C4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N16 compound treatment 1.65895108E8 2.54E7 0.32 1.8336843E8 3.68E7 0.63 0.6698 0.95 3084936 TimTec1_003470 CC(C)(C)n1nnc(n1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N17 compound treatment 8.9208088E7 -5.13E7 -0.64 1.6877398E8 2.22E7 0.38 -0.1871 -0.2503 3210818 TimTec1_003471 O=C(C1=NNC2C1C(=O)N(C2=O)c3ccccc3)c4cccnc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N18 compound treatment 1.58342175E8 1.78E7 0.22 1.64262836E8 1.77E7 0.3 0.3716 0.9889 1154895 TimTec1_003472 CCOc1ccc2nc(SCc3ccc4OCOc4c3)sc2c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N19 compound treatment 1.4719032E8 6650000.0 0.08 1.50216275E8 3610000.0 0.06 0.1026 0.989 1179027 TimTec1_003473 CCOC(=O)C1C(=S)NC(=C(C#N)C21CCCCC2)N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N20 compound treatment 1.76134854E8 3.56E7 0.45 1.64186689E8 1.76E7 0.3 0.5285 0.9815 1721930 TimTec1_003474 OC(c1nn(C2CC(=O)C3OCC2O3)c(=S)n1c4ccccc4)c5ccccc5 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N21 compound treatment 1.1521884E8 -2.53E7 -0.32 1.77416211E8 3.08E7 0.53 0.1483 0.2408 1317806 TimTec1_003475 O=c1cc(sc(=O)[nH]1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N22 compound treatment 1.64896615E8 2.44E7 0.31 1.82192693E8 3.56E7 0.61 0.6467 0.9491 1416310 TimTec1_003476 CCOC(=O)CSc1nc2ccccc2n1C(=O)Nc3cccc(Cl)c3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N23 mock treatment 1.04085951E8 -3.65E7 -0.46 1.75460335E8 2.89E7 0.49 0.0258 0.0384 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 N24 mock treatment 1.71610461E8 3.11E7 0.39 1.60078658E8 1.35E7 0.23 0.4386 0.9686 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O01 compound treatment 1.57770183E8 1.72E7 0.22 1.64513716E8 1.79E7 0.31 0.3695 0.9854 1395834 TimTec1_003477 COc1ccc(CNC(=O)c2ccc(C)c(C)c2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O02 compound treatment 1.42753234E8 2210000.0 0.03 1.62876247E8 1.63E7 0.28 0.2165 0.7737 1184377 TimTec1_003478 CCN(C(=O)C(C)Oc1ccccc1)c2ccccc2C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O03 compound treatment 1.43028203E8 2490000.0 0.03 1.64373244E8 1.78E7 0.3 0.2371 0.7756 1539114 TimTec1_003479 O=C(NC(c1ccccc1)c2ccccc2)c3ccco3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O04 compound treatment 1.01774135E8 -3.88E7 -0.49 1.66038509E8 1.94E7 0.33 -0.1087 -0.1845 3210819 TimTec1_003480 CC1CCCCN1C(=O)Cc2ccc(Cl)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O05 compound treatment 1.52509457E8 1.2E7 0.15 1.63184291E8 1.66E7 0.28 0.3068 0.9557 3084942 TimTec1_003481 CC(=O)N(Cc1ccccc1)c2ccccn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O06 compound treatment 1.51973165E8 1.14E7 0.14 1.6521974E8 1.86E7 0.32 0.3267 0.935 3210820 TimTec1_003482 CN(Cc1ccccc1)C(=O)CCc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O07 compound treatment 1.16281739E8 -2.43E7 -0.3 1.74305607E8 2.77E7 0.47 0.12 0.2131 1675811 TimTec1_003483 O=C(CC(c1ccccc1)c2ccccc2)NCCN3CCOCC3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O08 compound treatment 1.42856138E8 2310000.0 0.03 1.54431372E8 7820000.0 0.13 0.1152 0.8409 1696603 TimTec1_003484 NS(=O)(=O)c1ccc(NC(=O)C(Sc2ccccc2)c3ccccc3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O09 compound treatment 1.51927325E8 1.14E7 0.14 1.57893401E8 1.13E7 0.19 0.2376 0.989 1437606 TimTec1_003485 CN(Cc1ccccc1)C(=O)c2ccc3OCOc3c2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O10 compound treatment 1.02862784E8 -3.77E7 -0.47 1.67895589E8 2.13E7 0.36 -0.0766 -0.1283 1671134 TimTec1_003486 COc1cc(SC)ccc1C(=O)N2CCc3ccccc3C2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O11 compound treatment 1.10736361E8 -2.98E7 -0.37 1.79860127E8 3.33E7 0.57 0.1381 0.2028 1515374 TimTec1_003487 COc1ccc(cc1)C(=O)Nc2ccc(C)cn2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O12 compound treatment 1.05060636E8 -3.55E7 -0.45 1.76214029E8 2.96E7 0.51 0.0436 0.0646 1496160 TimTec1_003488 COC(=O)C1CCN(CC1)C(=O)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O13 compound treatment 1.50771163E8 1.02E7 0.13 1.59317204E8 1.27E7 0.22 0.2445 0.9683 1544697 TimTec1_003489 CCCC(C)NC(=O)N1CCOCC1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O14 compound treatment 1.61136179E8 2.06E7 0.26 1.88422E8 4.18E7 0.72 0.6888 0.9052 1536093 TimTec1_003490 COCC(C)NC(=O)c1cccc(OC)c1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O15 compound treatment 1.45871817E8 5330000.0 0.07 1.60979683E8 1.44E7 0.25 0.2212 0.8678 1517922 TimTec1_003491 O=C(C(Sc1ccccc1)c2ccccc2)N(CC#N)CC#N 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O16 compound treatment 1.75686922E8 3.51E7 0.44 1.02953324E8 -4.37E7 -0.75 -0.2167 -0.2497 3210821 TimTec1_003492 CCC(CC)NC(=O)Cc1ccc(Cl)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O17 compound treatment 1.62176367E8 2.16E7 0.27 1.96627371E8 5.0E7 0.86 0.7973 0.8877 1289736 TimTec1_003493 CCC(C(=O)NCC1CCCO1)c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O18 compound treatment 1.0981434E8 -3.07E7 -0.39 1.64888928E8 1.83E7 0.31 -0.0513 -0.1034 1234784 TimTec1_003494 COC(=O)C1CCN(CC1)C(=O)C(C)Oc2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O19 compound treatment 1.01053469E8 -3.95E7 -0.5 1.58946442E8 1.23E7 0.21 -0.201 -0.3732 1449934 TimTec1_003495 COc1cc(SC)ccc1C(=O)NC(C)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O20 compound treatment 1.44279684E8 3740000.0 0.05 1.76764574E8 3.02E7 0.52 0.3982 0.7682 3210822 TimTec1_003496 C/C(=N\c1ccc(cc1)C(=O)O)/c2cc3c(=O)n(C)c4ccccc4c3oc2=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O21 compound treatment 1.57485039E8 1.69E7 0.21 1.58298258E8 1.17E7 0.2 0.2918 0.9995 1156038 TimTec1_003497 CCOc1ccc(NC(=O)C(C)Oc2ccccc2)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O22 compound treatment 1.54216459E8 1.37E7 0.17 1.28054536E8 -1.86E7 -0.32 -0.1033 -0.2862 3085019 TimTec1_003498 OCc1coc(O)c(CN2CCc3ccccc3C2)c1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O23 mock treatment 9.8648474E7 -4.19E7 -0.53 1.69503969E8 2.29E7 0.39 -0.0945 -0.1441 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 O24 mock treatment 1.51453343E8 1.09E7 0.14 1.64558761E8 1.79E7 0.31 0.314 0.9337 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P01 compound treatment 1.62082923E8 2.15E7 0.27 1.03600614E8 -4.3E7 -0.74 -0.3295 -0.4202 3210823 TimTec1_003499 COC[C@@H]1N=C(C)OC1c2ccccc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P02 compound treatment 5.32042675E8 3.92E8 4.91 4.75723017E8 3.29E8 5.63 7.4564 0.9977 1133107 TimTec1_003500 CCN(CC)CCc1c(C)c2ccc(O)cc2oc1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P03 compound treatment 1.63782608E8 2.32E7 0.29 1.7199154E8 2.54E7 0.43 0.5134 0.9812 3085021 TimTec1_003501 Cc1ccc(NC(=O)c2ccn(n2)C(=O)Nc3cccc(Cl)c3)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P04 compound treatment 1.39800487E8 -742000.0 -0.01 1.38567017E8 -8040000.0 -0.14 -0.1039 -0.7532 3210824 TimTec1_003502 Cc1nnc(c2ccccc2)c(=O)n1/N=C/c3cccs3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P05 compound treatment 1.5804537E8 1.75E7 0.22 1.39581389E8 -7030000.0 -0.12 0.0702 0.2803 3210825 TimTec1_003503 OC(c1nnc(SCc2ccc(Br)cc2)n1c3ccccc3)c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P06 compound treatment 1.81685621E8 4.11E7 0.52 1.53763987E8 7150000.0 0.12 0.4515 0.8513 3085024 TimTec1_003504 CC1CCC(C)C(C1)NC(=O)c2ccc(I)cc2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P07 compound treatment 1.53640916E8 1.31E7 0.16 1.53407713E8 6800000.0 0.12 0.1985 0.9857 3210826 TimTec1_003505 CCN(C(=O)C)c1nnc(CSc2nc3ccccc3s2)s1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P08 compound treatment 2.52076005E8 1.12E8 1.4 2.64036295E8 1.17E8 2.01 2.4107 0.9843 3085026 TimTec1_003506 Cc1nc2cc3ccccc3cc2c(=O)n1CCCNC4CCCCC4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P09 compound treatment 1.72043273E8 3.15E7 0.4 1.64567487E8 1.8E7 0.31 0.4968 0.9923 1712637 TimTec1_003507 COCc1cc(C)nc2sc3c4nc5ccccc5n4nnc3c12 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P10 compound treatment 1.85130175E8 4.46E7 0.56 1.70424989E8 2.38E7 0.41 0.6838 0.9879 1522827 TimTec1_003508 O=C(Cc1cccc2ccccc12)NN3C(=O)C4C5CC(C=C5)C4C3=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P11 compound treatment 1.09432398E8 -3.11E7 -0.39 1.58670787E8 1.21E7 0.21 -0.13 -0.2944 1560331 TimTec1_003509 CC1(C)OC(=O)N(CC2CCCO2)C1(C)O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P12 compound treatment 1.31636185E8 -8910000.0 -0.11 1.59485467E8 1.29E7 0.22 0.0768 0.311 1246647 TimTec1_003510 O=C(Nc1nc(cs1)c2ccccc2)Oc3ccccc3 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P13 compound treatment 1.16176664E8 -2.44E7 -0.31 1.53085894E8 6480000.0 0.11 -0.1377 -0.4236 1591772 TimTec1_003511 Cc1nn2c3CC(C)(C)CC(=O)c3cnc2c1c4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P14 compound treatment 1.75567198E8 3.5E7 0.44 1.68528829E8 2.19E7 0.38 0.576 0.9969 3210827 TimTec1_003512 CCOC(=O)C1(O)CC(=NN1C(=O)c2cccc(Cl)c2)C 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P15 compound treatment 1.59788672E8 1.92E7 0.24 1.77559579E8 3.09E7 0.53 0.5453 0.9367 1520262 TimTec1_003513 COC(=O)c1ccc(cc1)C2N(Cc3ccccc3)CCN2Cc4ccccc4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P16 compound treatment 1.06763734E8 -3.38E7 -0.42 1.70316288E8 2.37E7 0.41 -0.0127 -0.0216 3085100 TimTec1_003514 OC1=C/C(=N\c2ccc(F)c(c2)C(F)(F)F)/c3ccccc3C1=O 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P17 compound treatment 1.53832784E8 1.33E7 0.17 1.55615967E8 9010000.0 0.15 0.2269 0.9992 1236032 TimTec1_003515 Fc1nc(F)c(F)c(SC(=S)N2CCOCC2)c1F 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P18 compound treatment 1.47946862E8 7400000.0 0.09 1.59746807E8 1.31E7 0.22 0.2247 0.9235 1437494 TimTec1_003516 CCC(C)c1ccc(NC(=O)C2CC=CCC2C(=O)O)cc1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P19 compound treatment 1.48892161E8 8350000.0 0.1 1.60885182E8 1.43E7 0.24 0.2469 0.9285 1266457 TimTec1_003517 CC(=O)OC1CC(C)(C)N(OC(=O)c2ccc(cc2)n3cnnn3)C(C)(C)C1 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P20 compound treatment 1.22049702E8 -1.85E7 -0.23 1.57614248E8 1.1E7 0.19 -0.0308 -0.1032 3085103 TimTec1_003518 NC(=N)SCc1nc(N)nc(n1)N2CCCCC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P21 compound treatment 1.59085758E8 1.85E7 0.23 1.55873528E8 9260000.0 0.16 0.2766 0.9826 3210828 TimTec1_003519 C(Sc1nnc(c2ccccc2)n1c3ccccc3)C4CCOCO4 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P22 compound treatment 1.56426882E8 1.59E7 0.2 1.67396196E8 2.08E7 0.36 0.3925 0.9625 1431856 TimTec1_003520 CCC(C)(OC1CCCCO1)C#CCN2CCN(C)CC2 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P23 mock treatment 1.55147747E8 1.46E7 0.18 1.73728446E8 2.71E7 0.46 0.4578 0.9173 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.2072 P24 mock treatment 1.08934598E8 -3.16E7 -0.4 1.69471769E8 2.29E7 0.39 -0.0036 -0.0065 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A01 mock treatment 2.5081477E7 -8.74E7 -1.1 5.0559831E7 -1.65E8 -2.83 -2.7739 -0.9149 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A02 mock treatment 2.9230213E7 -8.32E7 -1.04 5.6846967E7 -1.59E8 -2.72 -2.661 -0.9135 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A03 mock treatment 3.0717E7 -8.17E7 -1.03 5.467106E7 -1.61E8 -2.76 -2.6742 -0.9092 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A04 mock treatment 3.2658257E7 -7.98E7 -1.0 6.15174E7 -1.54E8 -2.64 -2.5741 -0.9119 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A05 mock treatment 3.7366957E7 -7.51E7 -0.94 1.23892843E8 -9.18E7 -1.57 -1.7773 -0.97 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A06 mock treatment 4.0608798E7 -7.18E7 -0.9 1.49695239E8 -6.6E7 -1.13 -1.4362 -0.9937 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A07 mock treatment 4.1034272E7 -7.14E7 -0.9 1.65722532E8 -5.0E7 -0.86 -1.2385 -0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A08 mock treatment 4.2500795E7 -6.99E7 -0.88 1.58176142E8 -5.75E7 -0.98 -1.3168 -0.9983 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A09 mock treatment 4.9044143E7 -6.34E7 -0.8 1.75021516E8 -4.07E7 -0.7 -1.0548 -0.9978 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A10 mock treatment 5.8579086E7 -5.39E7 -0.68 1.70379794E8 -4.53E7 -0.78 -1.0265 -0.9976 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A11 mock treatment 6.6147221E7 -4.63E7 -0.58 1.75105376E8 -4.06E7 -0.7 -0.9021 -0.996 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A12 mock treatment 7.04678E7 -4.2E7 -0.53 1.78694395E8 -3.7E7 -0.63 -0.8204 -0.9958 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A13 mock treatment 7.1944328E7 -4.05E7 -0.51 1.8454964E8 -3.12E7 -0.53 -0.7364 -0.9997 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A14 mock treatment 7.7363616E7 -3.51E7 -0.44 1.93530742E8 -2.22E7 -0.38 -0.5796 -0.9973 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A15 mock treatment 8.5748652E7 -2.67E7 -0.33 2.05374025E8 -1.03E7 -0.18 -0.3619 -0.9556 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A16 mock treatment 8.7021519E7 -2.54E7 -0.32 2.13728245E8 -1980000.0 -0.03 -0.2495 -0.778 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A17 mock treatment 8.7203139E7 -2.52E7 -0.32 2.06890891E8 -8820000.0 -0.15 -0.3306 -0.9426 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A18 mock treatment 7.3708484E7 -3.87E7 -0.49 2.14902139E8 -808000.0 -0.01 -0.3533 -0.727 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A19 mock treatment 5.5641237E7 -5.68E7 -0.71 2.11532191E8 -4180000.0 -0.07 -0.5544 -0.7742 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A20 mock treatment 8.1814782E7 -3.06E7 -0.38 2.13887143E8 -1820000.0 -0.03 -0.2937 -0.762 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A21 mock treatment 9.0192551E7 -2.22E7 -0.28 2.1012918E8 -5580000.0 -0.1 -0.2649 -0.898 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A22 mock treatment 9.1631043E7 -2.08E7 -0.26 2.05020853E8 -1.07E7 -0.18 -0.314 -0.9849 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A23 mock treatment 7.638391E7 -3.61E7 -0.45 2.05269936E8 -1.04E7 -0.18 -0.4462 -0.9175 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base A24 mock treatment 8.6696527E7 -2.57E7 -0.32 2.18401179E8 2690000.0 0.05 -0.1958 -0.6002 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B01 mock treatment 1.86189617E8 7.37E7 0.93 2.18777808E8 3070000.0 0.05 0.6913 0.746 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B02 mock treatment 1.81232523E8 6.88E7 0.86 2.21514321E8 5800000.0 0.1 0.6805 0.7833 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B03 mock treatment 1.7797625E8 6.55E7 0.82 2.33500346E8 1.78E7 0.3 0.7967 0.9087 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B04 mock treatment 1.73669004E8 6.12E7 0.77 2.31837923E8 1.61E7 0.28 0.7383 0.9046 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B05 mock treatment 1.72276528E8 5.98E7 0.75 2.21410321E8 5700000.0 0.1 0.5998 0.7924 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B06 mock treatment 1.61159253E8 4.87E7 0.61 2.23829962E8 8120000.0 0.14 0.5304 0.8463 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B07 mock treatment 1.53372547E8 4.09E7 0.51 2.24607195E8 8900000.0 0.15 0.4708 0.879 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B08 mock treatment 1.57330105E8 4.49E7 0.56 2.25585149E8 9870000.0 0.17 0.5177 0.8805 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B09 mock treatment 1.71985636E8 5.95E7 0.75 2.37860485E8 2.21E7 0.38 0.7963 0.9506 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B10 mock treatment 1.44571071E8 3.21E7 0.4 2.59011928E8 4.33E7 0.74 0.8091 0.959 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B11 mock treatment 1.3668714E8 2.42E7 0.3 2.16345143E8 635000.0 0.01 0.2228 0.7319 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B12 mock treatment 1.44812097E8 3.24E7 0.41 2.28238407E8 1.25E7 0.21 0.4388 0.9555 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B13 mock treatment 1.39496964E8 2.71E7 0.34 2.18228441E8 2520000.0 0.04 0.2705 0.7905 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B14 mock treatment 1.45962116E8 3.35E7 0.42 2.1925607E8 3550000.0 0.06 0.3403 0.8009 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B15 mock treatment 1.39106566E8 2.67E7 0.33 2.25413944E8 9700000.0 0.17 0.354 0.9478 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B16 mock treatment 1.39181179E8 2.67E7 0.34 2.26478574E8 1.08E7 0.18 0.3675 0.9602 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B17 mock treatment 1.37550106E8 2.51E7 0.31 2.16767309E8 1060000.0 0.02 0.2355 0.7465 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B18 mock treatment 1.2533626E8 1.29E7 0.16 2.26591978E8 1.09E7 0.19 0.2461 0.9975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B19 mock treatment 1.20476124E8 8040000.0 0.1 2.22099959E8 6390000.0 0.11 0.1486 0.9992 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B20 mock treatment 1.21132099E8 8690000.0 0.11 2.36369861E8 2.07E7 0.35 0.3272 0.8841 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B21 mock treatment 1.09397955E8 -3040000.0 -0.04 2.10900856E8 -4810000.0 -0.08 -0.0852 -0.9389 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B22 mock treatment 9.7715682E7 -1.47E7 -0.18 2.12863062E8 -2850000.0 -0.05 -0.1651 -0.8641 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B23 mock treatment 9.5123437E7 -1.73E7 -0.22 2.1646101E8 750000.0 0.01 -0.1445 -0.6641 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base B24 mock treatment 7.7390822E7 -3.5E7 -0.44 1.99821039E8 -1.59E7 -0.27 -0.5032 -0.9733 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C01 mock treatment 2.278809E7 -8.97E7 -1.12 4.406634E7 -1.72E8 -2.94 -2.8729 -0.9132 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C02 mock treatment 2.5248983E7 -8.72E7 -1.09 4.6502702E7 -1.69E8 -2.9 -2.8215 -0.9113 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C03 mock treatment 2.7854655E7 -8.46E7 -1.06 4.4960714E7 -1.71E8 -2.92 -2.8171 -0.906 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C04 mock treatment 2.9096724E7 -8.33E7 -1.05 5.9899005E7 -1.56E8 -2.67 -2.6253 -0.9164 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C05 mock treatment 3.4686851E7 -7.78E7 -0.98 1.0301784E8 -1.13E8 -1.93 -2.0537 -0.9501 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C06 mock treatment 3.5516555E7 -7.69E7 -0.96 1.22519446E8 -9.32E7 -1.6 -1.8103 -0.971 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C07 mock treatment 3.7122221E7 -7.53E7 -0.94 1.37689871E8 -7.8E7 -1.34 -1.6125 -0.9856 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C08 mock treatment 3.7701245E7 -7.47E7 -0.94 1.38678506E8 -7.7E7 -1.32 -1.5954 -0.986 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C09 mock treatment 3.879199E7 -7.36E7 -0.92 1.34858682E8 -8.09E7 -1.38 -1.6319 -0.9807 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C10 mock treatment 3.9818774E7 -7.26E7 -0.91 1.45325286E8 -7.04E7 -1.2 -1.4961 -0.9905 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C11 mock treatment 4.1154774E7 -7.13E7 -0.89 1.57132464E8 -5.86E7 -1.0 -1.3414 -0.9984 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C12 mock treatment 4.1394147E7 -7.1E7 -0.89 1.50412892E8 -6.53E7 -1.12 -1.4206 -0.9937 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C13 mock treatment 4.4889625E7 -6.76E7 -0.85 1.54107348E8 -6.16E7 -1.05 -1.3448 -0.9941 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C14 mock treatment 4.6497975E7 -6.59E7 -0.83 1.65407003E8 -5.03E7 -0.86 -1.1938 -0.9998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C15 mock treatment 4.2884382E7 -6.96E7 -0.87 1.71933268E8 -4.38E7 -0.75 -1.1469 -0.9971 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C16 mock treatment 4.3796797E7 -6.86E7 -0.86 1.84133933E8 -3.16E7 -0.54 -0.9911 -0.9748 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C17 mock treatment 6.1692175E7 -5.07E7 -0.64 1.74197905E8 -4.15E7 -0.71 -0.9526 -0.9985 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C18 mock treatment 6.8119616E7 -4.43E7 -0.56 1.81262367E8 -3.44E7 -0.59 -0.8101 -0.9996 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C19 mock treatment 7.5243278E7 -3.72E7 -0.47 1.86417409E8 -2.93E7 -0.5 -0.6845 -0.9994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C20 mock treatment 8.5186476E7 -2.73E7 -0.34 1.94130458E8 -2.16E7 -0.37 -0.503 -0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C21 mock treatment 8.4570207E7 -2.79E7 -0.35 1.84962339E8 -3.07E7 -0.53 -0.6194 -0.9802 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C22 mock treatment 9.0208913E7 -2.22E7 -0.28 1.94247974E8 -2.15E7 -0.37 -0.457 -0.9907 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C23 mock treatment 9.1729806E7 -2.07E7 -0.26 1.88339532E8 -2.74E7 -0.47 -0.515 -0.9613 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base C24 mock treatment 9.5721461E7 -1.67E7 -0.21 1.86727919E8 -2.9E7 -0.5 -0.4991 -0.9266 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D01 mock treatment 1.12996228E8 557000.0 0.01 2.05859085E8 -9850000.0 -0.17 -0.1143 -0.6773 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D02 mock treatment 1.33167972E8 2.07E7 0.26 2.17911337E8 2200000.0 0.04 0.2105 0.8012 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D03 mock treatment 1.61018006E8 4.86E7 0.61 2.0295545E8 -1.28E7 -0.22 0.2765 0.4272 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D04 mock treatment 1.5170503E8 3.93E7 0.49 2.06481113E8 -9230000.0 -0.16 0.2366 0.4574 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D05 mock treatment 1.69501858E8 5.71E7 0.72 2.12639804E8 -3070000.0 -0.05 0.469 0.6534 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D06 mock treatment 1.52180204E8 3.97E7 0.5 2.08213623E8 -7500000.0 -0.13 0.2618 0.5085 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D07 mock treatment 1.54897637E8 4.25E7 0.53 2.08621194E8 -7090000.0 -0.12 0.2908 0.5324 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D08 mock treatment 1.51056001E8 3.86E7 0.48 2.09207764E8 -6500000.0 -0.11 0.2638 0.5308 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D09 mock treatment 1.59209444E8 4.68E7 0.59 2.0768595E8 -8020000.0 -0.14 0.3177 0.5273 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D10 mock treatment 1.45479712E8 3.3E7 0.41 2.25483732E8 9770000.0 0.17 0.4114 0.9204 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D11 mock treatment 1.4817089E8 3.57E7 0.45 2.03249916E8 -1.25E7 -0.21 0.1661 0.3347 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D12 mock treatment 1.29969968E8 1.75E7 0.22 2.07761796E8 -7950000.0 -0.14 0.0593 0.2293 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D13 mock treatment 1.35562214E8 2.31E7 0.29 2.12818673E8 -2890000.0 -0.05 0.1701 0.5781 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D14 mock treatment 1.30083701E8 1.76E7 0.22 2.04429063E8 -1.13E7 -0.19 0.02 0.0679 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D15 mock treatment 1.23908751E8 1.15E7 0.14 2.07141407E8 -8570000.0 -0.15 -0.002 -0.0097 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D16 mock treatment 1.28621377E8 1.62E7 0.2 1.98752325E8 -1.7E7 -0.29 -0.0617 -0.1743 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D17 mock treatment 1.35256491E8 2.28E7 0.29 1.95909738E8 -1.98E7 -0.34 -0.0373 -0.084 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D18 mock treatment 1.30795252E8 1.84E7 0.23 1.99471131E8 -1.62E7 -0.28 -0.0337 -0.0935 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D19 mock treatment 1.19493383E8 7050000.0 0.09 2.0137439E8 -1.43E7 -0.25 -0.111 -0.4253 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D20 mock treatment 1.23459498E8 1.1E7 0.14 2.01754234E8 -1.4E7 -0.24 -0.0712 -0.2579 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D21 mock treatment 1.16061178E8 3620000.0 0.05 2.08260889E8 -7450000.0 -0.13 -0.058 -0.4288 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D22 mock treatment 1.12083446E8 -356000.0 0.0 1.94582078E8 -2.11E7 -0.36 -0.2589 -0.7158 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D23 mock treatment 1.06612311E8 -5830000.0 -0.07 1.898416E8 -2.59E7 -0.44 -0.3648 -0.8128 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base D24 mock treatment 1.05355167E8 -7080000.0 -0.09 1.83696602E8 -3.2E7 -0.55 -0.4503 -0.8112 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E01 mock treatment 2.5178625E7 -8.73E7 -1.09 5.6530324E7 -1.59E8 -2.72 -2.7008 -0.9197 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E02 mock treatment 2.8828575E7 -8.36E7 -1.05 6.269464E7 -1.53E8 -2.62 -2.5938 -0.9193 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E03 mock treatment 3.091414E7 -8.15E7 -1.02 5.8316448E7 -1.57E8 -2.69 -2.6283 -0.912 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E04 mock treatment 3.3286682E7 -7.92E7 -0.99 9.9063328E7 -1.17E8 -2.0 -2.114 -0.948 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E05 mock treatment 4.073827E7 -7.17E7 -0.9 1.62581681E8 -5.31E7 -0.91 -1.2791 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E06 mock treatment 3.613303E7 -7.63E7 -0.96 1.7134522E8 -4.44E7 -0.76 -1.2139 -0.9934 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E07 mock treatment 3.8931847E7 -7.35E7 -0.92 1.84136021E8 -3.16E7 -0.54 -1.0342 -0.9676 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E08 mock treatment 3.9553888E7 -7.29E7 -0.91 1.89344468E8 -2.64E7 -0.45 -0.9657 -0.9471 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E09 mock treatment 4.2473739E7 -7.0E7 -0.88 1.77787991E8 -3.79E7 -0.65 -1.0796 -0.989 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E10 mock treatment 4.2052364E7 -7.04E7 -0.88 1.9156648E8 -2.41E7 -0.41 -0.9166 -0.9402 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E11 mock treatment 4.6479974E7 -6.6E7 -0.83 1.89944519E8 -2.58E7 -0.44 -0.897 -0.9566 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E12 mock treatment 4.8441251E7 -6.4E7 -0.8 1.95325416E8 -2.04E7 -0.35 -0.8144 -0.9304 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E13 mock treatment 5.6952812E7 -5.55E7 -0.7 1.94277926E8 -2.14E7 -0.37 -0.7516 -0.9552 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E14 mock treatment 6.5667362E7 -4.68E7 -0.59 2.1469678E8 -1010000.0 -0.02 -0.4272 -0.7277 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E15 mock treatment 6.9527267E7 -4.29E7 -0.54 2.20575192E8 4860000.0 0.08 -0.3218 -0.5907 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E16 mock treatment 7.830498E7 -3.41E7 -0.43 2.19315015E8 3600000.0 0.06 -0.2592 -0.599 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E17 mock treatment 8.1316237E7 -3.11E7 -0.39 2.09792166E8 -5920000.0 -0.1 -0.3477 -0.862 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E18 mock treatment 8.7618514E7 -2.48E7 -0.31 2.16112367E8 402000.0 0.01 -0.2153 -0.6913 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E19 mock treatment 8.870753E7 -2.37E7 -0.3 2.13453208E8 -2260000.0 -0.04 -0.2378 -0.7922 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E20 mock treatment 1.02258228E8 -1.02E7 -0.13 2.51304636E8 3.56E7 0.61 0.3405 0.547 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E21 mock treatment 1.10133873E8 -2310000.0 -0.03 2.18669317E8 2960000.0 0.05 0.0154 0.2634 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E22 mock treatment 9.8646782E7 -1.38E7 -0.17 2.45177484E8 2.95E7 0.5 0.2343 0.4394 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E23 mock treatment 1.08922558E8 -3520000.0 -0.04 2.20313491E8 4600000.0 0.08 0.0245 0.2715 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base E24 mock treatment 1.17288547E8 4850000.0 0.06 2.07124124E8 -8590000.0 -0.15 -0.0609 -0.383 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F01 mock treatment 1.97520495E8 8.51E7 1.07 2.4804786E8 3.23E7 0.55 1.1461 0.9533 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F02 mock treatment 2.02793659E8 9.04E7 1.13 2.84809658E8 6.91E7 1.18 1.6379 0.9998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F03 mock treatment 1.91086335E8 7.86E7 0.99 2.77845445E8 6.21E7 1.06 1.4497 0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F04 mock treatment 2.03182163E8 9.07E7 1.14 2.89075975E8 7.34E7 1.26 1.6929 0.9988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F05 mock treatment 1.92567193E8 8.01E7 1.01 2.55895983E8 4.02E7 0.69 1.1972 0.9829 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F06 mock treatment 1.87320942E8 7.49E7 0.94 2.3745354E8 2.17E7 0.37 0.9274 0.9179 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F07 mock treatment 1.8257912E8 7.01E7 0.88 2.52721128E8 3.7E7 0.63 1.0701 0.987 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F08 mock treatment 1.87096309E8 7.47E7 0.94 2.61185524E8 4.55E7 0.78 1.2127 0.9958 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F09 mock treatment 1.758349E8 6.34E7 0.8 2.71849282E8 5.61E7 0.96 1.2419 0.9956 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F10 mock treatment 1.81473535E8 6.9E7 0.87 2.50904239E8 3.52E7 0.6 1.0383 0.9843 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F11 mock treatment 1.89794756E8 7.74E7 0.97 2.79029645E8 6.33E7 1.08 1.4526 0.9985 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F12 mock treatment 1.71497493E8 5.91E7 0.74 2.54009492E8 3.83E7 0.66 0.9874 0.9981 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F13 mock treatment 1.59989921E8 4.76E7 0.6 2.71107409E8 5.54E7 0.95 1.0923 0.975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F14 mock treatment 1.64152173E8 5.17E7 0.65 2.80677965E8 6.5E7 1.11 1.2451 0.9671 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F15 mock treatment 1.77261666E8 6.48E7 0.81 2.66354454E8 5.06E7 0.87 1.188 0.9995 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F16 mock treatment 1.68816608E8 5.64E7 0.71 2.57857049E8 4.21E7 0.72 1.0102 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F17 mock treatment 1.69944775E8 5.75E7 0.72 2.48305327E8 3.26E7 0.56 0.9046 0.9919 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F18 mock treatment 1.49126395E8 3.67E7 0.46 2.56612469E8 4.09E7 0.7 0.8205 0.9793 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F19 mock treatment 1.54179266E8 4.17E7 0.52 2.4103358E8 2.53E7 0.43 0.6768 0.9956 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F20 mock treatment 1.44811221E8 3.24E7 0.41 2.54723863E8 3.9E7 0.67 0.7594 0.9716 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F21 mock treatment 1.35713238E8 2.33E7 0.29 2.39963629E8 2.43E7 0.42 0.5 0.9852 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F22 mock treatment 1.34073586E8 2.16E7 0.27 2.48974976E8 3.33E7 0.57 0.5945 0.9425 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F23 mock treatment 1.25811917E8 1.34E7 0.17 2.21266328E8 5560000.0 0.1 0.1859 0.9639 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base F24 mock treatment 1.15977324E8 3540000.0 0.04 2.17445877E8 1740000.0 0.03 0.0524 0.9809 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G01 mock treatment 2.4085865E7 -8.84E7 -1.11 8.5524261E7 -1.3E8 -2.23 -2.3595 -0.948 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G02 mock treatment 2.8714055E7 -8.37E7 -1.05 9.8959184E7 -1.17E8 -2.0 -2.1559 -0.9549 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G03 mock treatment 2.8976533E7 -8.35E7 -1.05 7.7609465E7 -1.38E8 -2.36 -2.412 -0.9329 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G04 mock treatment 3.7265199E7 -7.52E7 -0.94 1.42028017E8 -7.37E7 -1.26 -1.5587 -0.9897 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G05 mock treatment 3.5344716E7 -7.71E7 -0.97 1.82881029E8 -3.28E7 -0.56 -1.0812 -0.9666 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G06 mock treatment 3.819746E7 -7.42E7 -0.93 1.82735604E8 -3.3E7 -0.56 -1.0577 -0.9712 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G07 mock treatment 4.3027326E7 -6.94E7 -0.87 2.00724965E8 -1.5E7 -0.26 -0.7971 -0.8781 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G08 mock treatment 4.040196E7 -7.2E7 -0.9 1.88177974E8 -2.75E7 -0.47 -0.9723 -0.9539 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G09 mock treatment 4.6767244E7 -6.57E7 -0.82 1.83149956E8 -3.26E7 -0.56 -0.9767 -0.9819 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G10 mock treatment 5.0285924E7 -6.22E7 -0.78 1.85794748E8 -2.99E7 -0.51 -0.9134 -0.9792 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G11 mock treatment 5.9844166E7 -5.26E7 -0.66 1.93728217E8 -2.2E7 -0.38 -0.7326 -0.9645 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G12 mock treatment 7.4516999E7 -3.79E7 -0.48 1.98537726E8 -1.72E7 -0.29 -0.5442 -0.9732 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G13 mock treatment 6.9519391E7 -4.29E7 -0.54 1.97074203E8 -1.86E7 -0.32 -0.6063 -0.9688 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G14 mock treatment 8.0218615E7 -3.22E7 -0.4 2.09638049E8 -6070000.0 -0.1 -0.3593 -0.8609 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G15 mock treatment 8.0351293E7 -3.21E7 -0.4 2.22796835E8 7090000.0 0.12 -0.1989 -0.473 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G16 mock treatment 8.1160539E7 -3.13E7 -0.39 2.19247855E8 3540000.0 0.06 -0.2346 -0.591 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G17 mock treatment 9.3536174E7 -1.89E7 -0.24 2.1479981E8 -911000.0 -0.02 -0.1787 -0.752 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G18 mock treatment 9.8093401E7 -1.43E7 -0.18 2.10950879E8 -4760000.0 -0.08 -0.1849 -0.9358 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G19 mock treatment 9.4350004E7 -1.81E7 -0.23 2.19367354E8 3660000.0 0.06 -0.1162 -0.4936 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G20 mock treatment 1.07812616E8 -4630000.0 -0.06 2.16503339E8 793000.0 0.01 -0.0314 -0.5276 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G21 mock treatment 1.0917069E8 -3270000.0 -0.04 2.2470963E8 9000000.0 0.15 0.0799 0.5014 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G22 mock treatment 1.1847707E8 6040000.0 0.08 2.24495898E8 8790000.0 0.15 0.1599 0.9496 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G23 mock treatment 1.25716558E8 1.33E7 0.17 2.26929272E8 1.12E7 0.19 0.2536 0.9975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base G24 mock treatment 1.24643834E8 1.22E7 0.15 2.14411004E8 -1300000.0 -0.02 0.0925 0.5981 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H01 mock treatment 1.86285372E8 7.38E7 0.93 2.49846275E8 3.41E7 0.58 1.0682 0.9753 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H02 mock treatment 1.97935538E8 8.55E7 1.07 2.48720097E8 3.3E7 0.57 1.1579 0.9552 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H03 mock treatment 2.01305327E8 8.89E7 1.11 2.48177872E8 3.25E7 0.56 1.1813 0.9483 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H04 mock treatment 1.84545283E8 7.21E7 0.9 2.52696951E8 3.7E7 0.63 1.0873 0.9848 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H05 mock treatment 2.04853358E8 9.24E7 1.16 2.47717683E8 3.2E7 0.55 1.2072 0.9414 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H06 mock treatment 1.87781282E8 7.53E7 0.95 2.45278604E8 2.96E7 0.51 1.0262 0.9572 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H07 mock treatment 1.76999964E8 6.46E7 0.81 2.30158264E8 1.44E7 0.25 0.7475 0.8828 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H08 mock treatment 1.88661598E8 7.62E7 0.96 2.43154018E8 2.74E7 0.47 1.0083 0.9465 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H09 mock treatment 1.83466364E8 7.1E7 0.89 2.29030626E8 1.33E7 0.23 0.7913 0.8603 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H10 mock treatment 1.68276674E8 5.58E7 0.7 2.22751517E8 7040000.0 0.12 0.5805 0.8168 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H11 mock treatment 1.68343895E8 5.59E7 0.7 2.2953242E8 1.38E7 0.24 0.6632 0.896 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H12 mock treatment 1.66207778E8 5.38E7 0.67 2.14792252E8 -918000.0 -0.02 0.4658 0.6904 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H13 mock treatment 1.72077101E8 5.96E7 0.75 2.14922209E8 -788000.0 -0.01 0.5195 0.6942 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H14 mock treatment 1.62356244E8 4.99E7 0.63 2.32738568E8 1.7E7 0.29 0.6489 0.9395 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H15 mock treatment 1.65418937E8 5.3E7 0.66 2.13545828E8 -2160000.0 -0.04 0.4437 0.6666 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H16 mock treatment 1.54130736E8 4.17E7 0.52 2.25278729E8 9570000.0 0.16 0.4856 0.8861 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H17 mock treatment 1.54467534E8 4.2E7 0.53 2.2560286E8 9890000.0 0.17 0.4925 0.8895 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H18 mock treatment 1.47871359E8 3.54E7 0.44 2.17637303E8 1930000.0 0.03 0.3376 0.7575 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H19 mock treatment 1.43151438E8 3.07E7 0.39 2.19433635E8 3720000.0 0.06 0.3175 0.813 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H20 mock treatment 1.37272201E8 2.48E7 0.31 2.31721197E8 1.6E7 0.27 0.4141 0.998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H21 mock treatment 1.36740139E8 2.43E7 0.3 2.179734E8 2260000.0 0.04 0.2429 0.7906 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H22 mock treatment 1.28202003E8 1.58E7 0.2 2.27425992E8 1.17E7 0.2 0.2816 1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H23 mock treatment 1.25441615E8 1.3E7 0.16 2.20774182E8 5060000.0 0.09 0.1766 0.9562 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base H24 mock treatment 1.231601E8 1.07E7 0.13 2.14361769E8 -1350000.0 -0.02 0.0788 0.5773 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I01 mock treatment 2.6035371E7 -8.64E7 -1.08 6.7312926E7 -1.48E8 -2.54 -2.5627 -0.9279 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I02 mock treatment 3.0122531E7 -8.23E7 -1.03 6.3843604E7 -1.52E8 -2.6 -2.5684 -0.9182 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I03 mock treatment 3.1742443E7 -8.07E7 -1.01 6.9179634E7 -1.47E8 -2.51 -2.4895 -0.9204 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I04 mock treatment 3.2939747E7 -7.95E7 -1.0 9.4563174E7 -1.21E8 -2.07 -2.1716 -0.9437 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I05 mock treatment 3.7077466E7 -7.54E7 -0.95 1.42759416E8 -7.3E7 -1.25 -1.5515 -0.9906 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I06 mock treatment 3.8233049E7 -7.42E7 -0.93 1.57650229E8 -5.81E7 -0.99 -1.361 -0.9995 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I07 mock treatment 4.1246948E7 -7.12E7 -0.89 1.67993296E8 -4.77E7 -0.82 -1.2091 -0.999 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I08 mock treatment 4.2662214E7 -6.98E7 -0.88 1.69193729E8 -4.65E7 -0.8 -1.182 -0.9989 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I09 mock treatment 4.1396441E7 -7.1E7 -0.89 1.63194183E8 -5.25E7 -0.9 -1.2658 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I10 mock treatment 4.5171019E7 -6.73E7 -0.84 1.7075404E8 -4.5E7 -0.77 -1.1409 -0.9989 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I11 mock treatment 4.705789E7 -6.54E7 -0.82 1.78541934E8 -3.72E7 -0.64 -1.0299 -0.9921 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I12 mock treatment 4.8920237E7 -6.35E7 -0.8 1.96032297E8 -1.97E7 -0.34 -0.8016 -0.9266 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I13 mock treatment 5.741189E7 -5.5E7 -0.69 1.94195413E8 -2.15E7 -0.37 -0.7485 -0.9567 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I14 mock treatment 5.8343668E7 -5.41E7 -0.68 2.05073553E8 -1.06E7 -0.18 -0.6086 -0.8662 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I15 mock treatment 6.9173877E7 -4.33E7 -0.54 1.91815125E8 -2.39E7 -0.41 -0.673 -0.9903 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I16 mock treatment 7.5815335E7 -3.66E7 -0.46 2.01382277E8 -1.43E7 -0.25 -0.4983 -0.9568 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I17 mock treatment 7.3134326E7 -3.93E7 -0.49 2.03725331E8 -1.2E7 -0.21 -0.4937 -0.9245 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I18 mock treatment 8.6626215E7 -2.58E7 -0.32 2.02545106E8 -1.32E7 -0.23 -0.3883 -0.9843 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I19 mock treatment 8.0171228E7 -3.23E7 -0.4 1.90334718E8 -2.54E7 -0.43 -0.5934 -0.9994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I20 mock treatment 9.7842569E7 -1.46E7 -0.18 2.09295109E8 -6420000.0 -0.11 -0.2071 -0.9701 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I21 mock treatment 1.02214989E8 -1.02E7 -0.13 2.18673938E8 2960000.0 0.05 -0.0548 -0.3975 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I22 mock treatment 1.05163783E8 -7280000.0 -0.09 2.19845735E8 4140000.0 0.07 -0.0145 -0.1254 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I23 mock treatment 1.14442306E8 2000000.0 0.03 2.12516335E8 -3190000.0 -0.05 -0.0209 -0.3473 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base I24 mock treatment 1.18661485E8 6220000.0 0.08 2.11267473E8 -4440000.0 -0.08 0.0014 0.0129 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J01 mock treatment 1.25098416E8 1.27E7 0.16 2.35278438E8 1.96E7 0.33 0.3491 0.9418 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J02 mock treatment 6.0183392E7 -5.23E7 -0.66 2.37956245E8 2.22E7 0.38 -0.1943 -0.2562 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J03 mock treatment 1.63823623E8 5.14E7 0.64 2.57402597E8 4.17E7 0.71 0.9604 0.9987 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J04 mock treatment 1.93272852E8 8.08E7 1.01 2.79718181E8 6.4E7 1.1 1.4918 0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J05 mock treatment 1.93210152E8 8.08E7 1.01 2.61165007E8 4.55E7 0.78 1.2667 0.9915 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J06 mock treatment 1.73267563E8 6.08E7 0.76 2.40642503E8 2.49E7 0.43 0.8413 0.9623 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J07 mock treatment 1.60592427E8 4.82E7 0.6 2.32109876E8 1.64E7 0.28 0.6256 0.9392 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J08 mock treatment 1.73768675E8 6.13E7 0.77 2.57789001E8 4.21E7 0.72 1.0533 0.9995 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J09 mock treatment 1.57485341E8 4.5E7 0.57 2.55303833E8 3.96E7 0.68 0.8788 0.9959 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J10 mock treatment 1.67693295E8 5.53E7 0.69 2.32636673E8 1.69E7 0.29 0.695 0.9251 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J11 mock treatment 1.7184746E8 5.94E7 0.75 2.56083982E8 4.04E7 0.69 1.0157 0.9993 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J12 mock treatment 1.6745581E8 5.5E7 0.69 2.10177098E8 -5530000.0 -0.09 0.421 0.6044 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J13 mock treatment 1.54873974E8 4.24E7 0.53 2.2356135E8 7850000.0 0.13 0.4714 0.8587 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J14 mock treatment 1.65178792E8 5.27E7 0.66 2.4183707E8 2.61E7 0.45 0.7841 0.9818 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J15 mock treatment 1.64291425E8 5.19E7 0.65 2.32634238E8 1.69E7 0.29 0.6648 0.9336 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J16 mock treatment 7.3209488E7 -3.92E7 -0.49 2.57602549E8 4.19E7 0.72 0.1591 0.1829 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J17 mock treatment 1.05255583E8 -7180000.0 -0.09 2.53638514E8 3.79E7 0.65 0.3954 0.6032 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J18 mock treatment 5.6550917E7 -5.59E7 -0.7 2.41676922E8 2.6E7 0.44 -0.1814 -0.2186 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J19 mock treatment 7.6293178E7 -3.61E7 -0.45 2.32582808E8 1.69E7 0.29 -0.1164 -0.2165 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J20 mock treatment 5.1084573E7 -6.14E7 -0.77 2.42775942E8 2.71E7 0.46 -0.2166 -0.2411 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J21 mock treatment 5.869262E7 -5.37E7 -0.67 2.34934327E8 1.92E7 0.33 -0.2441 -0.3253 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J22 mock treatment 4.5332618E7 -6.71E7 -0.84 1.94781115E8 -2.09E7 -0.36 -0.8486 -0.9275 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J23 mock treatment 6.4692854E7 -4.77E7 -0.6 2.15501543E8 -209000.0 0.0 -0.4261 -0.7113 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base J24 mock treatment 9.338428E7 -1.91E7 -0.24 2.04654637E8 -1.11E7 -0.19 -0.3029 -0.9933 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K01 mock treatment 2.5556495E7 -8.69E7 -1.09 5.0564564E7 -1.65E8 -2.83 -2.7696 -0.9141 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K02 mock treatment 3.0147903E7 -8.23E7 -1.03 5.7802531E7 -1.58E8 -2.7 -2.6413 -0.9128 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K03 mock treatment 3.0759422E7 -8.17E7 -1.02 5.5324566E7 -1.6E8 -2.75 -2.6659 -0.9097 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K04 mock treatment 3.2759801E7 -7.97E7 -1.0 1.08526215E8 -1.07E8 -1.83 -2.0042 -0.9592 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K05 mock treatment 4.2359573E7 -7.01E7 -0.88 1.83124363E8 -3.26E7 -0.56 -1.0161 -0.9759 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K06 mock treatment 3.9468656E7 -7.3E7 -0.92 1.79608825E8 -3.61E7 -0.62 -1.0843 -0.9817 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K07 mock treatment 4.1035403E7 -7.14E7 -0.9 1.97133208E8 -1.86E7 -0.32 -0.8582 -0.9029 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K08 mock treatment 4.126896E7 -7.12E7 -0.89 1.92433491E8 -2.33E7 -0.4 -0.9131 -0.9339 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K09 mock treatment 4.0972675E7 -7.15E7 -0.9 1.90266127E8 -2.54E7 -0.44 -0.9419 -0.945 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K10 mock treatment 4.4157757E7 -6.83E7 -0.86 1.94636545E8 -2.11E7 -0.36 -0.8608 -0.9261 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K11 mock treatment 4.0824596E7 -7.16E7 -0.9 1.8684721E8 -2.89E7 -0.49 -0.9846 -0.9603 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K12 mock treatment 4.4353919E7 -6.81E7 -0.85 1.83242928E8 -3.25E7 -0.56 -0.9969 -0.9783 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K13 mock treatment 4.3161248E7 -6.93E7 -0.87 1.86695182E8 -2.9E7 -0.5 -0.9657 -0.9648 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K14 mock treatment 4.5115556E7 -6.73E7 -0.84 1.97298147E8 -1.84E7 -0.32 -0.8201 -0.9097 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K15 mock treatment 4.5884564E7 -6.66E7 -0.83 1.95810361E8 -1.99E7 -0.34 -0.8312 -0.9218 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K16 mock treatment 5.1048647E7 -6.14E7 -0.77 1.8987343E8 -2.58E7 -0.44 -0.8573 -0.9653 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K17 mock treatment 5.7914722E7 -5.45E7 -0.68 1.93022155E8 -2.27E7 -0.39 -0.7583 -0.964 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K18 mock treatment 6.5871901E7 -4.66E7 -0.58 1.85590878E8 -3.01E7 -0.52 -0.7776 -0.9981 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K19 mock treatment 7.064801E7 -4.18E7 -0.52 1.98983939E8 -1.67E7 -0.29 -0.5732 -0.9595 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K20 mock treatment 7.5606706E7 -3.68E7 -0.46 2.0009667E8 -1.56E7 -0.27 -0.5157 -0.9661 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K21 mock treatment 8.0044461E7 -3.24E7 -0.41 2.03536949E8 -1.22E7 -0.21 -0.4347 -0.9519 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K22 mock treatment 8.2372043E7 -3.01E7 -0.38 1.99587341E8 -1.61E7 -0.28 -0.4619 -0.9882 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K23 mock treatment 9.5540968E7 -1.69E7 -0.21 2.07840814E8 -7870000.0 -0.13 -0.2452 -0.9761 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base K24 mock treatment 9.0975733E7 -2.15E7 -0.27 2.02173731E8 -1.35E7 -0.23 -0.3542 -0.9972 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L01 mock treatment 1.99564082E8 8.71E7 1.09 2.12115781E8 -3590000.0 -0.06 0.7293 0.6662 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L02 mock treatment 1.88785466E8 7.63E7 0.96 2.19778389E8 4070000.0 0.07 0.7264 0.7565 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L03 mock treatment 1.95023853E8 8.26E7 1.04 2.10736315E8 -4970000.0 -0.09 0.6723 0.6468 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L04 mock treatment 1.86872964E8 7.44E7 0.93 2.23231156E8 7520000.0 0.13 0.7513 0.7971 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L05 mock treatment 2.02419246E8 9.0E7 1.13 2.41931561E8 2.62E7 0.45 1.1155 0.9183 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L06 mock treatment 1.72426641E8 6.0E7 0.75 2.10707452E8 -5000000.0 -0.09 0.4715 0.6226 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L07 mock treatment 1.71847873E8 5.94E7 0.75 2.13740042E8 -1970000.0 -0.03 0.5031 0.6744 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L08 mock treatment 1.95310074E8 8.29E7 1.04 2.30498237E8 1.48E7 0.25 0.9141 0.8543 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L09 mock treatment 1.87218975E8 7.48E7 0.94 2.19626412E8 3920000.0 0.07 0.7107 0.7557 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L10 mock treatment 1.70027788E8 5.76E7 0.72 2.29330562E8 1.36E7 0.23 0.6757 0.8901 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L11 mock treatment 1.72670428E8 6.02E7 0.76 2.37662795E8 2.2E7 0.38 0.8 0.948 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L12 mock treatment 1.82905717E8 7.05E7 0.88 2.31685856E8 1.6E7 0.27 0.8184 0.8845 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L13 mock treatment 1.47886567E8 3.54E7 0.44 2.165517E8 841000.0 0.01 0.3246 0.7296 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L14 mock treatment 1.56930676E8 4.45E7 0.56 2.14529298E8 -1180000.0 -0.02 0.3804 0.681 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L15 mock treatment 1.56210256E8 4.38E7 0.55 2.27981123E8 1.23E7 0.21 0.5368 0.9131 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L16 mock treatment 1.56779287E8 4.43E7 0.56 2.39030663E8 2.33E7 0.4 0.6756 0.9868 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L17 mock treatment 1.58154107E8 4.57E7 0.57 2.25310472E8 9600000.0 0.16 0.5217 0.8745 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L18 mock treatment 1.45353378E8 3.29E7 0.41 2.30971379E8 1.53E7 0.26 0.4767 0.9756 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L19 mock treatment 1.36233764E8 2.38E7 0.3 2.23826624E8 8120000.0 0.14 0.3093 0.9395 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L20 mock treatment 1.24394029E8 1.2E7 0.15 2.3247493E8 1.68E7 0.29 0.309 0.9542 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L21 mock treatment 1.19669303E8 7230000.0 0.09 2.23053961E8 7340000.0 0.13 0.153 0.9872 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L22 mock treatment 1.04421218E8 -8020000.0 -0.1 2.01526143E8 -1.42E7 -0.24 -0.2428 -0.9239 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L23 mock treatment 1.05487837E8 -6950000.0 -0.09 2.09636314E8 -6070000.0 -0.1 -0.1352 -0.9962 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base L24 mock treatment 9.9442704E7 -1.3E7 -0.16 2.05072428E8 -1.06E7 -0.18 -0.2441 -0.9985 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M01 mock treatment 2.3870936E7 -8.86E7 -1.11 4.4527903E7 -1.71E8 -2.93 -2.8577 -0.9119 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M02 mock treatment 2.8291516E7 -8.41E7 -1.06 6.3630199E7 -1.52E8 -2.6 -2.5872 -0.921 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M03 mock treatment 2.9890114E7 -8.25E7 -1.04 6.8092459E7 -1.48E8 -2.53 -2.519 -0.9224 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M04 mock treatment 3.3826608E7 -7.86E7 -0.99 1.1005116E8 -1.06E8 -1.81 -1.9762 -0.9593 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M05 mock treatment 3.8676623E7 -7.38E7 -0.93 1.62656674E8 -5.31E7 -0.91 -1.2965 -1.0 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M06 mock treatment 4.0320369E7 -7.21E7 -0.9 1.91909356E8 -2.38E7 -0.41 -0.9278 -0.9351 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M07 mock treatment 4.0121206E7 -7.23E7 -0.91 1.90195636E8 -2.55E7 -0.44 -0.9503 -0.9438 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M08 mock treatment 4.0185495E7 -7.23E7 -0.91 1.892401E8 -2.65E7 -0.45 -0.9613 -0.9487 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M09 mock treatment 4.4000063E7 -6.84E7 -0.86 1.92540817E8 -2.32E7 -0.4 -0.8875 -0.9385 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M10 mock treatment 5.1853205E7 -6.06E7 -0.76 2.04862917E8 -1.08E7 -0.19 -0.6687 -0.8547 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M11 mock treatment 5.0514159E7 -6.19E7 -0.78 2.00506307E8 -1.52E7 -0.26 -0.7333 -0.8951 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M12 mock treatment 5.9919984E7 -5.25E7 -0.66 2.0925097E8 -6460000.0 -0.11 -0.5441 -0.8144 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M13 mock treatment 6.6881065E7 -4.56E7 -0.57 2.25145669E8 9440000.0 0.16 -0.2899 -0.4882 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M14 mock treatment 7.2615353E7 -3.98E7 -0.5 2.09880761E8 -5830000.0 -0.1 -0.4238 -0.8319 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M15 mock treatment 8.0181621E7 -3.23E7 -0.4 2.22062108E8 6350000.0 0.11 -0.2093 -0.4994 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M16 mock treatment 8.4934478E7 -2.75E7 -0.35 2.16017999E8 307000.0 0.01 -0.2403 -0.6962 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M17 mock treatment 8.7076038E7 -2.54E7 -0.32 2.09607794E8 -6100000.0 -0.1 -0.2989 -0.8924 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M18 mock treatment 9.8535066E7 -1.39E7 -0.17 2.2322138E8 7510000.0 0.13 -0.0324 -0.1496 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M19 mock treatment 1.04211949E8 -8230000.0 -0.1 2.29866172E8 1.42E7 0.24 0.0984 0.3735 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M20 mock treatment 1.09253204E8 -3190000.0 -0.04 2.02505217E8 -1.32E7 -0.23 -0.1881 -0.8194 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M21 mock treatment 1.09915814E8 -2520000.0 -0.03 2.13504961E8 -2210000.0 -0.04 -0.0491 -0.9962 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M22 mock treatment 1.16835352E8 4400000.0 0.06 2.26475969E8 1.08E7 0.18 0.1693 0.8801 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M23 mock treatment 1.22683904E8 1.02E7 0.13 2.16513847E8 803000.0 0.01 0.1006 0.7783 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base M24 mock treatment 1.29805008E8 1.74E7 0.22 2.0466512E8 -1.1E7 -0.19 0.0203 0.0705 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N01 mock treatment 1.94107457E8 8.17E7 1.02 2.18149805E8 2440000.0 0.04 0.7539 0.7353 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N02 mock treatment 2.02219632E8 8.98E7 1.13 2.22504673E8 6790000.0 0.12 0.8786 0.776 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N03 mock treatment 2.08220001E8 9.58E7 1.2 2.33356656E8 1.76E7 0.3 1.0632 0.8582 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N04 mock treatment 2.21808198E8 1.09E8 1.37 2.50240759E8 3.45E7 0.59 1.3881 0.9292 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N05 mock treatment 2.10056606E8 9.76E7 1.22 2.19562587E8 3850000.0 0.07 0.9125 0.7441 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N06 mock treatment 2.03210118E8 9.08E7 1.14 2.45691496E8 3.0E7 0.51 1.1681 0.9352 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N07 mock treatment 2.0648994E8 9.41E7 1.18 2.19944103E8 4230000.0 0.07 0.8855 0.7491 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N08 mock treatment 2.05964015E8 9.35E7 1.17 2.28657504E8 1.29E7 0.22 0.9863 0.8261 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N09 mock treatment 2.08834484E8 9.64E7 1.21 2.45206023E8 2.95E7 0.5 1.2121 0.925 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N10 mock treatment 2.07852444E8 9.54E7 1.2 2.45987501E8 3.03E7 0.52 1.2128 0.9299 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N11 mock treatment 1.87266632E8 7.48E7 0.94 2.22057527E8 6350000.0 0.11 0.7406 0.7837 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N12 mock treatment 1.91504336E8 7.91E7 0.99 2.20378843E8 4670000.0 0.08 0.7578 0.7616 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N13 mock treatment 1.8886457E8 7.64E7 0.96 2.19003771E8 3290000.0 0.06 0.7178 0.7474 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N14 mock treatment 1.85182509E8 7.27E7 0.91 2.24656747E8 8950000.0 0.15 0.7535 0.8144 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N15 mock treatment 1.85636046E8 7.32E7 0.92 2.29256794E8 1.35E7 0.23 0.8132 0.8587 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N16 mock treatment 1.77516363E8 6.51E7 0.82 2.1568777E8 -22800.0 0.0 0.577 0.7068 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N17 mock treatment 1.81236172E8 6.88E7 0.86 2.43682193E8 2.8E7 0.48 0.9488 0.9614 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N18 mock treatment 1.69281843E8 5.68E7 0.71 2.28296113E8 1.26E7 0.22 0.6565 0.8814 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N19 mock treatment 1.71932279E8 5.95E7 0.75 2.42619403E8 2.69E7 0.46 0.8534 0.9731 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N20 mock treatment 1.64047468E8 5.16E7 0.65 2.27681315E8 1.2E7 0.2 0.6027 0.8875 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N21 mock treatment 1.71477139E8 5.9E7 0.74 2.29651661E8 1.39E7 0.24 0.6924 0.8899 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N22 mock treatment 1.54754178E8 4.23E7 0.53 2.32846875E8 1.71E7 0.29 0.5828 0.9609 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N23 mock treatment 1.39604583E8 2.72E7 0.34 2.15697186E8 -13400.0 0.0 0.2408 0.7066 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base N24 mock treatment 1.32041226E8 1.96E7 0.25 1.98175866E8 -1.75E7 -0.3 -0.0384 -0.0989 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O01 mock treatment 2.8746813E7 -8.37E7 -1.05 1.14724501E8 -1.01E8 -1.73 -1.9647 -0.9714 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O02 mock treatment 2.9889146E7 -8.26E7 -1.04 1.25053212E8 -9.07E7 -1.55 -1.8296 -0.9807 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O03 mock treatment 3.1659453E7 -8.08E7 -1.01 1.22692311E8 -9.3E7 -1.59 -1.8425 -0.9762 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O04 mock treatment 3.444305E7 -7.8E7 -0.98 1.69516276E8 -4.62E7 -0.79 -1.251 -0.9944 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O05 mock treatment 3.7118224E7 -7.53E7 -0.94 2.07259299E8 -8450000.0 -0.14 -0.7704 -0.806 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O06 mock treatment 5.4608726E7 -5.78E7 -0.73 2.195256E8 3820000.0 0.07 -0.4668 -0.6409 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O07 mock treatment 6.5209725E7 -4.72E7 -0.59 2.21638945E8 5930000.0 0.1 -0.3472 -0.5776 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O08 mock treatment 6.925865E7 -4.32E7 -0.54 2.20460905E8 4750000.0 0.08 -0.3255 -0.5943 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O09 mock treatment 7.7273822E7 -3.52E7 -0.44 2.29499472E8 1.38E7 0.24 -0.145 -0.2899 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O10 mock treatment 8.8860733E7 -2.36E7 -0.3 2.33065496E8 1.74E7 0.3 9.0E-4 0.0022 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O11 mock treatment 1.03055595E8 -9380000.0 -0.12 2.42266445E8 2.66E7 0.45 0.2382 0.5073 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O12 mock treatment 1.07940563E8 -4500000.0 -0.06 2.46469932E8 3.08E7 0.53 0.3324 0.6277 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O13 mock treatment 1.13541583E8 1100000.0 0.01 2.47682605E8 3.2E7 0.55 0.3968 0.7247 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O14 mock treatment 1.18652204E8 6210000.0 0.08 2.44394199E8 2.87E7 0.49 0.4023 0.8092 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O15 mock treatment 1.27826232E8 1.54E7 0.19 2.51851637E8 3.61E7 0.62 0.5739 0.8856 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O16 mock treatment 1.37377662E8 2.49E7 0.31 2.44315646E8 2.86E7 0.49 0.5675 0.9766 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O17 mock treatment 1.54612345E8 4.22E7 0.53 2.53835091E8 3.81E7 0.65 0.8356 0.9946 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O18 mock treatment 1.63232862E8 5.08E7 0.64 2.49072297E8 3.34E7 0.57 0.8544 0.9985 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O19 mock treatment 1.73915638E8 6.15E7 0.77 2.48567054E8 3.29E7 0.56 0.943 0.988 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O20 mock treatment 1.76383545E8 6.39E7 0.8 2.34540717E8 1.88E7 0.32 0.7951 0.9198 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O21 mock treatment 1.80377764E8 6.79E7 0.85 2.39741087E8 2.4E7 0.41 0.8935 0.9442 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O22 mock treatment 1.82805379E8 7.04E7 0.88 2.32598237E8 1.69E7 0.29 0.8286 0.8921 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O23 mock treatment 1.88082208E8 7.56E7 0.95 2.42155972E8 2.64E7 0.45 0.9911 0.9427 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base O24 mock treatment 1.77487441E8 6.5E7 0.82 2.17024376E8 1310000.0 0.02 0.5929 0.7263 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P01 mock treatment 2.25896458E8 1.13E8 1.42 2.53767519E8 3.81E7 0.65 1.467 0.9372 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P02 mock treatment 2.06206341E8 9.38E7 1.18 2.46383538E8 3.07E7 0.53 1.203 0.9339 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P03 mock treatment 2.07119153E8 9.47E7 1.19 2.5265076E8 3.69E7 0.63 1.287 0.9565 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P04 mock treatment 2.02445223E8 9.0E7 1.13 2.40395199E8 2.47E7 0.42 1.0972 0.9101 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P05 mock treatment 1.913693E8 7.89E7 0.99 2.56939368E8 4.12E7 0.71 1.1992 0.9862 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P06 mock treatment 1.88857729E8 7.64E7 0.96 2.60296746E8 4.46E7 0.76 1.2175 0.9936 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P07 mock treatment 2.06726928E8 9.43E7 1.18 2.44509382E8 2.88E7 0.49 1.1849 0.9247 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P08 mock treatment 1.96728552E8 8.43E7 1.06 2.46318643E8 3.06E7 0.52 1.1182 0.9475 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P09 mock treatment 2.20739758E8 1.08E8 1.36 2.41317927E8 2.56E7 0.44 1.2706 0.8901 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P10 mock treatment 2.22963295E8 1.11E8 1.39 2.42854203E8 2.71E7 0.46 1.3089 0.8951 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P11 mock treatment 2.19719522E8 1.07E8 1.35 2.39458833E8 2.37E7 0.41 1.2391 0.8814 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P12 mock treatment 2.23971444E8 1.12E8 1.4 2.41479936E8 2.58E7 0.44 1.3012 0.887 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P13 mock treatment 2.1759398E8 1.05E8 1.32 2.26698205E8 1.1E7 0.19 1.0657 0.7998 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P14 mock treatment 2.23728896E8 1.11E8 1.4 2.18786907E8 3080000.0 0.05 1.0244 0.7333 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P15 mock treatment 2.21702736E8 1.09E8 1.37 2.47032504E8 3.13E7 0.54 1.3483 0.9161 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P16 mock treatment 2.15657862E8 1.03E8 1.29 2.40981954E8 2.53E7 0.43 1.2215 0.8947 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P17 mock treatment 2.10849997E8 9.84E7 1.23 2.49667766E8 3.4E7 0.58 1.284 0.941 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P18 mock treatment 1.95770945E8 8.33E7 1.05 2.38213028E8 2.25E7 0.39 1.0116 0.908 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P19 mock treatment 2.07634852E8 9.52E7 1.19 2.48107738E8 3.24E7 0.55 1.2366 0.9392 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P20 mock treatment 1.82792098E8 7.04E7 0.88 2.4687309E8 3.12E7 0.53 1.0012 0.9709 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P21 mock treatment 2.05987847E8 9.35E7 1.17 2.43142219E8 2.74E7 0.47 1.1618 0.9192 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P22 mock treatment 1.9961199E8 8.72E7 1.09 2.34846524E8 1.91E7 0.33 1.0049 0.8803 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P23 mock treatment 1.92346841E8 7.99E7 1.0 2.29918477E8 1.42E7 0.24 0.8808 0.8539 1071.0007 FluorDeLys(1071.0007) Sir2Modulation 1071.0007.Base P24 mock treatment 1.83572247E8 7.11E7 0.89 2.23498846E8 7790000.0 0.13 0.7252 0.8038