ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B RAW_VALUE_C BSUB_VALUE_C Z_SCORE_C RAW_VALUE_D BSUB_VALUE_D Z_SCORE_D COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A01 compound treatment 905010.0 1740.0 0.01 890720.0 -47200.0 -0.24 817730.0 30564.0625 0.1682643313395 859580.0 79883.0 0.476652749047886 0.2093 0.3752 1953974 Maybridge1_005457 Cc1c(sc2ccc(Cl)cc12)c3csc(n3)c4ccc(Cl)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A02 compound treatment 790260.0 -113000.0 -0.65 822300.0 -116000.0 -0.58 730000.0 -57165.9375 -0.31471563208697 780390.0 693.0 0.00413505195210727 -0.7673 -0.832 1117656 Maybridge1_005458 Oc1cc(=O)n(c2ccccc2)c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A03 compound treatment 885860.0 -17400.0 -0.1 966520.0 28600.0 0.14 799940.0 12774.0625 0.0703250454697076 832240.0 52543.0 0.31351808761843 0.2137 0.5846 1953975 Maybridge1_005459 FC(F)(F)COc1cccc(OCC(F)(F)F)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A04 compound treatment 933620.0 30300.0 0.17 959860.0 21900.0 0.11 824160.0 36994.0625 0.203663409930999 906500.0 126803.0 0.75661903706069 0.6217 0.7675 1248358 Maybridge1_005460 Oc1c(c2ccccc2)c(=O)[nH]c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A05 compound treatment 934510.0 31200.0 0.18 951070.0 13100.0 0.07 852820.0 65654.0625 0.361445306110216 847700.0 68003.0 0.405766144154618 0.5057 0.8784 1953976 Maybridge1_005461 COc1cccc(OCC(F)(F)F)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A06 compound treatment 947730.0 44500.0 0.25 959790.0 21900.0 0.11 819280.0 32114.0625 0.176797546241028 817680.0 37983.0 0.226640228422641 0.3834 0.9612 1953977 Maybridge1_005462 c1cncc(c1)c2n[nH]c(n2)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A07 compound treatment 780440.0 -123000.0 -0.7 820710.0 -117000.0 -0.59 691270.0 -95895.9375 -0.527935898626435 737370.0 -42327.0 -0.252560380918967 -1.0342 -0.9527 1698693 Maybridge1_005463 Fc1cccc(OCc2ccc(Cl)cc2)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A08 compound treatment 1037610.0 134000.0 0.77 764130.0 -174000.0 -0.87 887070.0 99904.0625 0.550001828934297 929970.0 150273.0 0.896661849926429 0.6724 0.4295 1953978 Maybridge1_005464 CCCCN1C(=O)/C(=N/Nc2ccc(C#N)cc2)/C(=C(C#N)C1=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A09 compound treatment 781150.0 -122000.0 -0.7 718090.0 -220000.0 -1.1 671960.0 -115205.9375 -0.634243240399661 719150.0 -60547.0 -0.361277042632379 -1.3964 -0.9354 1953979 Maybridge1_005465 FC(F)(F)c1cc(cc(c1)C23NCCN3C(=O)c4ccccc42)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A10 compound treatment 994080.0 90800.0 0.52 1002210.0 64300.0 0.32 849290.0 62124.0625 0.342011597334478 899800.0 120103.0 0.716640901304386 0.9494 0.948 1071329 Maybridge1_005466 CC(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)OC(=O)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A11 compound treatment 958490.0 55200.0 0.32 1015640.0 77700.0 0.39 830620.0 43454.0625 0.239227647520592 862470.0 82773.0 0.493897049396501 0.7186 0.9675 1953980 Maybridge1_005467 OC(=O)c1ccc(COCOCc2ccc(o2)C(=O)O)o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A12 compound treatment 942990.0 39700.0 0.23 906000.0 -31900.0 -0.16 798240.0 11074.0625 0.0609660355777095 741490.0 -38207.0 -0.227976810871807 -0.0499 -0.1371 1953981 Maybridge1_005468 CC12CCC3C(CCc4cc(Oc5ccc(cc5)[N+](=O)[O-])ccc34)C2CC[C@@]1(O)C#C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A13 compound treatment 1006680.0 103000.0 0.59 945350.0 7420.0 0.04 842770.0 55604.0625 0.306117041748697 841440.0 61743.0 0.368413438209176 0.6512 0.8552 1953982 Maybridge1_005469 Fc1ccc(NC(=S)NCCCn2ccnc2)c(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A14 compound treatment 897220.0 -6050.0 -0.03 990760.0 52800.0 0.26 784320.0 -2845.9375 -0.0156677395379462 882420.0 102723.0 0.612936423775346 0.4135 0.6184 1011811 Maybridge1_005470 CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C2CCC1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A15 compound treatment 970530.0 67300.0 0.38 1000540.0 62600.0 0.31 807880.0 20714.0625 0.114037126965276 798400.0 18703.0 0.111598667619426 0.4615 0.8863 1633463 Maybridge1_005471 CC(C)(C)c1ccc(cc1)c2nc3cc(Cl)ccc3c(=O)o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A16 compound treatment 963200.0 59900.0 0.34 959200.0 21300.0 0.11 824970.0 37804.0625 0.20812270287954 860590.0 80893.0 0.482679303841 0.5698 0.8955 1953983 Maybridge1_005472 CCSC(SCC)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H](COC(=O)C)OC(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A17 compound treatment 882020.0 -21300.0 -0.12 804450.0 -133000.0 -0.67 815520.0 28354.0625 0.156097618479903 774720.0 -4977.0 -0.0296971912924067 -0.3313 -0.4754 384 Maybridge1_005473 O=c1[nH]c2ccccc2c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A18 compound treatment 1102340.0 199000.0 1.14 989960.0 52000.0 0.26 878480.0 91314.0625 0.502711302480023 880840.0 101143.0 0.603508743999979 1.2518 0.8901 1004231 Maybridge1_005474 CC1=CC(C)(C)NC(=S)N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A19 compound treatment 915840.0 12600.0 0.07 1019140.0 81200.0 0.41 836180.0 49014.0625 0.269837115167363 864350.0 84653.0 0.505114794952001 0.6265 0.8876 1953984 Maybridge1_005475 CN(C)c1ccc(cc1)C(=O)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A20 compound treatment 822100.0 -81200.0 -0.46 772710.0 -165000.0 -0.83 696100.0 -91065.9375 -0.501345299933287 736260.0 -43437.0 -0.259183624305459 -1.0253 -0.9296 1003531 Maybridge1_005476 OC(=O)c1ccccc1NC(=O)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A21 compound treatment 920960.0 17700.0 0.1 965340.0 27400.0 0.14 842720.0 55554.0625 0.305841776751874 861990.0 82293.0 0.491032944148288 0.5175 0.8581 1953985 Maybridge1_005477 CC(=O)c1c(C)nn(c1c2ccccc2[N+](=O)[O-])c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A22 compound treatment 965130.0 61900.0 0.35 946560.0 8630.0 0.04 869120.0 81954.0625 0.451181695074669 886190.0 106493.0 0.635431583745684 0.7416 0.8655 1953986 Maybridge1_005478 COC(=O)c1ccccc1SC(CC(=O)c2ccccc2)c3ccc(F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A23 mock treatment 1014290.0 111000.0 0.63 1008410.0 70500.0 0.35 870640.0 83474.0625 0.459549750978102 890740.0 111043.0 0.662580914744368 1.0544 0.972 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 A24 mock treatment 1009760.0 106000.0 0.61 933300.0 -4630.0 -0.02 896090.0 108924.0625 0.599659634361252 859080.0 79383.0 0.473669306080997 0.8292 0.8488 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B01 compound treatment 963480.0 60200.0 0.34 892670.0 -45300.0 -0.23 820160.0 32994.0625 0.181642210185121 796090.0 16393.0 0.0978151611124018 0.1985 0.431 1953987 Maybridge1_005479 NC(=S)NCc1ccc(F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B02 compound treatment 796650.0 -107000.0 -0.61 811550.0 -126000.0 -0.63 769540.0 -17625.9375 -0.0970360725989657 764590.0 -15107.0 -0.0901417458015649 -0.7142 -0.8045 1161665 Maybridge1_005480 Cn1c2NCN(CCc3ccccc3)Cc2c(=O)n(C)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B03 compound treatment 778730.0 -125000.0 -0.71 770800.0 -167000.0 -0.84 772360.0 -14805.9375 -0.0815111267781216 746400.0 -33297.0 -0.198679400936963 -0.9138 -0.817 1953988 Maybridge1_005481 COc1cc(/C=C\2/N=C(OC2=O)c3ccccc3I)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B04 compound treatment 760520.0 -143000.0 -0.82 674320.0 -264000.0 -1.32 684670.0 -102495.9375 -0.564270878207134 676700.0 -102997.0 -0.614571350521201 -1.6564 -0.9408 1614749 Maybridge1_005482 COc1ccc(cc1)C(=O)Cc2c(O)c3ccccc3oc2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B05 compound treatment 818800.0 -84500.0 -0.48 817400.0 -121000.0 -0.6 743320.0 -43845.9375 -0.241385036933196 707360.0 -72337.0 -0.431626627791607 -0.8792 -0.9588 1953989 Maybridge1_005483 OC(=O)CC(CC(=O)O)c1ccc(cc1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B06 compound treatment 841360.0 -61900.0 -0.35 855050.0 -82900.0 -0.41 672220.0 -114945.9375 -0.632811862416179 712830.0 -66867.0 -0.398987761733848 -0.9 -0.9724 1953990 Maybridge1_005484 CC(=O)Nc1ccc(/C=C(\C#N)/c2ccc(C)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B07 compound treatment 642660.0 -261000.0 -1.49 713680.0 -224000.0 -1.12 625350.0 -161815.9375 -0.890845270438505 571650.0 -208047.0 -1.24139271786445 -2.3713 -0.9839 1953991 Maybridge1_005485 CCOC(=O)C1C(C(C(=O)OCC)C(O)(NC1(O)C(F)(F)F)C(F)(F)F)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B08 compound treatment 684820.0 -218000.0 -1.25 663010.0 -275000.0 -1.38 549680.0 -237485.9375 -1.30743131663115 583690.0 -196007.0 -1.16955141122177 -2.55 -0.9982 1074669 Maybridge1_005486 O=c1c2cccc3cccc(c4nc5ccccc5n14)c32 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B09 compound treatment 824820.0 -78500.0 -0.45 894570.0 -43400.0 -0.22 736410.0 -50755.9375 -0.279426659494201 743810.0 -35887.0 -0.214133635505445 -0.5793 -0.95 1953992 Maybridge1_005487 CN(C)C(=O)Nc1ccc(C)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B10 compound treatment 843780.0 -59500.0 -0.34 843360.0 -94600.0 -0.47 686240.0 -100925.9375 -0.555627557306876 732340.0 -47357.0 -0.282573817165864 -0.8255 -0.9677 1297284 Maybridge1_005488 CCOc1ccc(NC(C(=O)O)c2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B11 compound treatment 751220.0 -152000.0 -0.87 767040.0 -171000.0 -0.85 667160.0 -120005.9375 -0.660668680094715 651370.0 -128327.0 -0.765712571223765 -1.5749 -0.9945 1953993 Maybridge1_005489 Fc1ccc(cc1)n2ncc3ccccc3c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B12 compound treatment 791440.0 -112000.0 -0.64 959080.0 21100.0 0.11 713070.0 -74095.9375 -0.407920360011399 842520.0 62823.0 0.374857675017655 -0.2831 -0.3322 1953994 Maybridge1_005490 CCOc1ccc(/C=C\2/N=C(OC2=O)c3cccc(c3)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B13 compound treatment 736270.0 -167000.0 -0.95 833120.0 -105000.0 -0.52 654460.0 -132705.9375 -0.730585989287878 694170.0 -85527.0 -0.510329853258122 -1.3596 -0.9664 1953995 Maybridge1_005491 O=c1n(CCc2ccccc2)ncc3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B14 compound treatment 261780.0 -641000.0 -3.66 425300.0 -513000.0 -2.56 263380.0 -523785.9375 -2.88359868844238 243680.0 -536017.0 -3.1983522975652 -6.1552 -0.9914 1953996 Maybridge1_005492 CCOc1ccc(/C=C(\C#N)/c2nc3ccccc3[nH]2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B15 compound treatment 926970.0 23700.0 0.14 879950.0 -58000.0 -0.29 765540.0 -21625.9375 -0.119057272344844 731520.0 -48177.0 -0.287466663631561 -0.2806 -0.6286 1953997 Maybridge1_005493 Cc1ccc(cc1)N2N=C(CC2c3ccc4OCOc4c3)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B16 compound treatment 642030.0 -261000.0 -1.49 642880.0 -295000.0 -1.48 430740.0 -356425.9375 -1.96223169107484 461620.0 -318077.0 -1.8979291771579 -3.4141 -0.9915 1953998 Maybridge1_005494 COc1ccc(/C=C(\C#N)/c2ccc(cc2)[N+](=O)[O-])cc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B17 compound treatment 702400.0 -201000.0 -1.15 779410.0 -159000.0 -0.79 604290.0 -182875.9375 -1.00678688710055 651470.0 -128227.0 -0.765115882630388 -1.8561 -0.9859 1953999 Maybridge1_005495 COc1ccc(/C=C/2\CCc3ccccc3C2=O)c(Cl)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B18 compound treatment 903840.0 567.0 0.0 881250.0 -56700.0 -0.28 744770.0 -42395.9375 -0.233402352025316 830410.0 50713.0 0.302598686359619 -0.1055 -0.2218 1954000 Maybridge1_005496 CC(O)CN1C(=O)c2cccc3cccc(C1=O)c23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B19 compound treatment 853280.0 -50000.0 -0.29 872680.0 -65300.0 -0.33 775650.0 -11515.9375 -0.0633986899871369 780830.0 1133.0 0.00676048176296903 -0.3343 -0.7626 1587071 Maybridge1_005497 CC1=C(C)CC(C(C1)C(=O)O)C(=O)Nc2ccc3OCOc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B20 compound treatment 904270.0 997.0 0.01 959200.0 21300.0 0.11 712040.0 -75125.9375 -0.413590818945963 769170.0 -10527.0 -0.0628134082248675 -0.1822 -0.422 1954001 Maybridge1_005498 Brc1ccc2C(=O)N(Cc3cccnc3)C(=O)c4cccc1c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B21 compound treatment 826420.0 -76900.0 -0.44 944990.0 7060.0 0.04 745470.0 -41695.9375 -0.229548642069787 818160.0 38463.0 0.229504333670854 -0.2019 -0.369 1954002 Maybridge1_005499 OC(=O)c1ccccc1/C=C\2/SC(=S)NC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B22 compound treatment 950270.0 47000.0 0.27 904970.0 -33000.0 -0.16 767090.0 -20075.9375 -0.110524057443316 785510.0 5813.0 0.0346855079330441 0.0139 0.0414 1954003 Maybridge1_005500 Clc1ccc(NCN2C(=O)c3ccccc3C2=O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B23 mock treatment 952890.0 49600.0 0.28 1004680.0 66700.0 0.33 955950.0 168784.0625 0.929206888558317 920680.0 140983.0 0.841229479601644 1.1939 0.8992 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 B24 mock treatment 978240.0 75000.0 0.43 1023730.0 85800.0 0.43 905540.0 118374.0625 0.651684718760889 902240.0 122543.0 0.731200102982801 1.1201 0.9724 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C01 compound treatment 705040.0 -198000.0 -1.13 749990.0 -188000.0 -0.94 732000.0 -55165.9375 -0.303705032214031 684390.0 -95307.0 -0.568685997690458 -1.4724 -0.9164 1954004 Maybridge1_005501 Cc1nc(cs1)c2sc3ccccc3c2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C02 compound treatment 732750.0 -171000.0 -0.97 708640.0 -229000.0 -1.15 740330.0 -46835.9375 -0.25784588374324 652480.0 -127217.0 -0.759089327837273 -1.5689 -0.9202 1210275 Maybridge1_005502 O=C1C(C(=O)N(C(=O)N1c2ccccc2)c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C03 compound treatment 710890.0 -192000.0 -1.1 728280.0 -210000.0 -1.05 718300.0 -68865.9375 -0.379127641343664 663760.0 -115937.0 -0.691782854504272 -1.6092 -0.9402 1954005 Maybridge1_005503 Fc1cccc(OCC(F)(F)F)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C04 compound treatment 636740.0 -267000.0 -1.52 659880.0 -278000.0 -1.39 578890.0 -208275.9375 -1.14662150548688 599460.0 -180237.0 -1.07545362004611 -2.5677 -0.9902 1065642 Maybridge1_005504 Cc1ccc(cc1)S(=O)(=O)OCC2(CCC3CC2)CC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C05 compound treatment 766040.0 -137000.0 -0.78 726350.0 -212000.0 -1.06 691360.0 -95805.9375 -0.527440421632152 632170.0 -147527.0 -0.880276781152278 -1.625 -0.9733 1954006 Maybridge1_005505 CCOc1cccc(OCC(F)(F)F)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C06 compound treatment 628510.0 -275000.0 -1.57 767300.0 -171000.0 -0.85 592270.0 -194895.9375 -1.07296059233692 617000.0 -162697.0 -0.970794440767671 -2.2334 -0.9714 1954007 Maybridge1_005506 CC(C)c1cc(C(C)C)c([N+](=O)[O-])c(c1)C(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C07 compound treatment 749880.0 -153000.0 -0.88 807870.0 -130000.0 -0.65 643330.0 -143835.9375 -0.791859977580783 588360.0 -191337.0 -1.14168605391104 -1.7302 -0.9793 1954008 Maybridge1_005507 Cc1ccc(Sc2cccc(F)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C08 compound treatment 75210.0 -828000.0 -4.73 134170.0 -804000.0 -4.02 84820.0 -702345.9375 -3.86662504509837 105150.0 -674547.0 -4.02494500597129 -8.321 -0.9968 1954009 Maybridge1_005508 COc1ccc(/C=C(\C#N)/c2ccc(cc2)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C09 compound treatment 763590.0 -140000.0 -0.8 817300.0 -121000.0 -0.6 672670.0 -114495.9375 -0.630334477444768 701690.0 -78007.0 -0.465458871036121 -1.2485 -0.9826 1954010 Maybridge1_005509 CCOC(=O)NC(=S)N1CCOCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C10 compound treatment 695920.0 -207000.0 -1.18 708230.0 -230000.0 -1.15 594800.0 -192365.9375 -1.05903218349765 585380.0 -194317.0 -1.15946737399369 -2.2759 -0.9991 1954011 Maybridge1_005510 C[C@]1(O)CCC2C3CCC4=CC(=O)CCC4C3CCC21C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C11 compound treatment 758490.0 -145000.0 -0.83 773150.0 -165000.0 -0.82 735840.0 -51325.9375 -0.282564680457988 647880.0 -131817.0 -0.786537003132646 -1.3602 -0.9473 1954012 Maybridge1_005511 CCOC(=O)NC(=S)NCCC1CCNCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C12 compound treatment 731290.0 -172000.0 -0.98 705760.0 -232000.0 -1.16 594090.0 -193075.9375 -1.06294094645254 600320.0 -179377.0 -1.07032209814307 -2.1385 -0.9983 1954013 Maybridge1_005512 CC(=O)OC1CCC2(COC3CC4C5CCC(OC(=O)c6ccccc6)C5(C)CCC42)[C@]3(Br)C1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C13 compound treatment 977200.0 73900.0 0.42 888100.0 -49800.0 -0.25 732910.0 -54255.9375 -0.298695209271844 716040.0 -63657.0 -0.379834057886425 -0.2527 -0.3671 1954014 Maybridge1_005513 Cc1cc(Br)c(NC(=S)NN)c(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C14 compound treatment 753180.0 -150000.0 -0.86 804370.0 -134000.0 -0.67 675520.0 -111645.9375 -0.614644372625829 694040.0 -85657.0 -0.511105548429513 -1.3256 -0.9825 1954015 Maybridge1_005514 CC(=O)OC1CCC2C3CC[C@H]4CC(OC(=O)C)/C(=C/c5ccccc5)/CC4(C)C3CCC12C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C15 compound treatment 635230.0 -268000.0 -1.53 694590.0 -243000.0 -1.22 553520.0 -233645.9375 -1.28629096487511 561680.0 -218017.0 -1.3008825706242 -2.6677 -0.9961 1954016 Maybridge1_005515 CCC(C#N)(c1ccccc1)c2ccc(/N=C/c3cc(Cl)cc(Cl)c3O)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C16 compound treatment 719470.0 -184000.0 -1.05 751680.0 -186000.0 -0.93 649600.0 -137565.9375 -0.757341746979119 610730.0 -168967.0 -1.00820681557245 -1.8735 -0.9929 1954017 Maybridge1_005516 Nc1nc2ccc(cc2s1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C17 compound treatment 676400.0 -227000.0 -1.3 755360.0 -183000.0 -0.91 634840.0 -152325.9375 -0.838599974041409 618450.0 -161247.0 -0.962142456163695 -2.0049 -0.9851 1954018 Maybridge1_005517 OCc1cccc2cccc(I)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C18 compound treatment 326460.0 -577000.0 -3.3 322650.0 -615000.0 -3.08 173610.0 -613555.9375 -3.37780946373924 386120.0 -393577.0 -2.34842906515804 -6.0493 -0.9911 1705887 Maybridge1_005518 Cn1c(=O)c(I)c(O)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C19 compound treatment 716200.0 -187000.0 -1.07 777120.0 -161000.0 -0.8 668480.0 -118685.9375 -0.653401684178575 664710.0 -114987.0 -0.686114312867184 -1.6062 -0.98 1954019 Maybridge1_005519 CC(C)(C)c1ccc(cc1[N+](=O)[O-])C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C20 compound treatment 323360.0 -580000.0 -3.31 305920.0 -632000.0 -3.16 241160.0 -546005.9375 -3.00592645303073 238960.0 -540737.0 -3.22651599917262 -6.3531 -0.9994 1954020 Maybridge1_005520 COc1ccc(/C=C(\C#N)/c2ccccn2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C21 compound treatment 702780.0 -200000.0 -1.15 733320.0 -205000.0 -1.02 646250.0 -140915.9375 -0.775784501766292 650260.0 -129437.0 -0.772335814610257 -1.8584 -0.9853 1954021 Maybridge1_005521 CC1=NN(C(=O)C1)c2c(Cl)cc(Cl)cc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C22 compound treatment 780690.0 -123000.0 -0.7 769140.0 -169000.0 -0.84 684890.0 -102275.9375 -0.56305971222111 706520.0 -73177.0 -0.436638811975979 -1.2721 -0.9726 1197943 Maybridge1_005522 COC(=O)c1ccccc1SC(CC(=O)c2cccnc2)c3ccc(F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C23 mock treatment 811840.0 -91400.0 -0.52 803410.0 -135000.0 -0.67 767090.0 -20075.9375 -0.110524057443316 786930.0 7233.0 0.043158485959007 -0.6313 -0.734 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 C24 mock treatment 738590.0 -165000.0 -0.94 825600.0 -112000.0 -0.56 722960.0 -64205.9375 -0.353472943639716 778560.0 -1137.0 -0.00678434930670413 -0.9314 -0.809 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D01 compound treatment 702190.0 -201000.0 -1.15 775840.0 -162000.0 -0.81 749810.0 -37355.9375 -0.205655640345509 755680.0 -24017.0 -0.143306699471516 -1.1542 -0.8082 1954022 Maybridge1_005523 OCCCCCCNC(=S)Nc1ccc(F)cc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D02 compound treatment 752850.0 -150000.0 -0.86 738580.0 -199000.0 -1.0 691120.0 -96045.9375 -0.528761693616905 657120.0 -122577.0 -0.731402977104549 -1.5583 -0.9764 1391290 Maybridge1_005524 OC(=O)COCC(=O)Nc1cccnc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D03 compound treatment 773280.0 -130000.0 -0.74 764110.0 -174000.0 -0.87 660810.0 -126355.9375 -0.695627334691296 668820.0 -110877.0 -0.661590411679362 -1.4846 -0.9944 1337707 Maybridge1_005525 OC(=O)C(Cc1ccccc1)NC(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D04 compound treatment 683040.0 -220000.0 -1.26 742290.0 -196000.0 -0.98 622470.0 -164695.9375 -0.906700534255537 611930.0 -167767.0 -1.00104655245192 -2.0722 -0.9919 1143718 Maybridge1_005526 Cc1cc(C)cc(c1)N2C(=O)CC(Sc3ccccc3C(=O)O)C2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D05 compound treatment 702080.0 -201000.0 -1.15 735520.0 -202000.0 -1.01 667850.0 -119315.9375 -0.656870023138551 625180.0 -154517.0 -0.921985313829378 -1.8703 -0.982 1623738 Maybridge1_005527 CC1=CCC2C(C1)C(=O)N(C2=O)c3ccc(I)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D06 compound treatment 592720.0 -311000.0 -1.77 628260.0 -310000.0 -1.55 578570.0 -208595.9375 -1.14838320146655 515690.0 -264007.0 -1.57529965471859 -3.0233 -0.9889 1954023 Maybridge1_005528 Cc1ccc(cc1)/C(=C/c2ccc3OCOc3c2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D07 compound treatment 752040.0 -151000.0 -0.86 814100.0 -124000.0 -0.62 663050.0 -124115.9375 -0.683295462833604 761760.0 -17937.0 -0.107028032994153 -1.1368 -0.8964 1954024 Maybridge1_005529 OC(=O)CC(CC(=O)Nc1ccc(I)cc1F)c2ccc(cc2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D08 compound treatment 700260.0 -203000.0 -1.16 790090.0 -148000.0 -0.74 629970.0 -157195.9375 -0.865410784732016 620450.0 -159247.0 -0.950208684296141 -1.8574 -0.9867 1024809 Maybridge1_005530 O=C1Nc2ccccc2SC1c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D09 compound treatment 787860.0 -115000.0 -0.66 801690.0 -136000.0 -0.68 691250.0 -95915.9375 -0.528046004625164 626330.0 -153367.0 -0.915123395005534 -1.3919 -0.9805 1954025 Maybridge1_005531 CN(C)C(=O)Nc1cccc(Cl)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D10 compound treatment 688120.0 -215000.0 -1.23 693400.0 -245000.0 -1.22 599110.0 -188055.9375 -1.03530434077147 579790.0 -199907.0 -1.1928222663635 -2.3401 -0.9977 1954026 Maybridge1_005532 COc1ccc(/C=C\2/N=C(C)OC2=O)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D11 compound treatment 752000.0 -151000.0 -0.86 781130.0 -157000.0 -0.78 693280.0 -93885.9375 -0.516870245754131 644830.0 -134867.0 -0.804736005230665 -1.485 -0.9842 1954027 Maybridge1_005533 OC(=O)c1ccccc1/C=N/Nc2cc(Cl)ccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D12 compound treatment 906730.0 3460.0 0.02 800730.0 -137000.0 -0.69 768230.0 -18935.9375 -0.104248015515741 701680.0 -78017.0 -0.465518539895458 -0.6181 -0.7394 1008681 Maybridge1_005534 COc1cc(cc(OC)c1OC)C(=O)NCC(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D13 compound treatment 760480.0 -143000.0 -0.82 942930.0 5000.0 0.02 653620.0 -133545.9375 -0.735210441234512 758630.0 -21067.0 -0.125704385966874 -0.8258 -0.7469 1954028 Maybridge1_005535 C1Oc2ccc(cc2O1)C3CC(=Nc4ccccc4S3)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D14 compound treatment 414720.0 -489000.0 -2.79 444010.0 -494000.0 -2.47 357570.0 -429595.9375 -2.36505448742631 396740.0 -382957.0 -2.28506073654133 -4.9557 -0.997 1954029 Maybridge1_005536 Clc1ccc(/C=C(\C#N)/c2nc3ccccc3[nH]2)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D15 compound treatment 735380.0 -168000.0 -0.96 688180.0 -250000.0 -1.25 688770.0 -98395.9375 -0.541699148467608 634560.0 -145137.0 -0.866015923770552 -1.808 -0.9632 1954030 Maybridge1_005537 O=C/1C2CCN(CC2)\C1=C\c3cccc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D16 compound treatment 739040.0 -164000.0 -0.94 852660.0 -85300.0 -0.43 735050.0 -52115.9375 -0.286913867407799 701670.0 -78027.0 -0.465578208754796 -1.0586 -0.9073 1954031 Maybridge1_005538 O=C1N(CCCN2CCN(CCCN3C(=O)c4cccc5cccc(C3=O)c45)CC2)C(=O)c6cccc7cccc1c67 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D17 compound treatment 862990.0 -40300.0 -0.23 804890.0 -133000.0 -0.67 728650.0 -58515.9375 -0.322147787001204 659360.0 -120337.0 -0.718037152612889 -0.9679 -0.9166 1954032 Maybridge1_005539 O=C/1/C(=C/c2cccs2)/COC\C1=C/c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D18 compound treatment 227730.0 -676000.0 -3.86 347410.0 -591000.0 -2.95 261670.0 -525495.9375 -2.89301275133374 221610.0 -558087.0 -3.33004147012365 -6.5178 -0.9931 1954033 Maybridge1_005540 [O-][N+](=O)c1ccc2C(=O)N(Cc3ccco3)C(=O)c4cccc1c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D19 compound treatment 653460.0 -250000.0 -1.43 967610.0 29700.0 0.15 714920.0 -72245.9375 -0.397735555128931 697280.0 -82417.0 -0.491772838004076 -1.0841 -0.6914 1717190 Maybridge1_005541 OC(=O)C1c2ccccc2C(=O)N(C3CCCCC3)C41CCCCC4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D20 compound treatment 738560.0 -165000.0 -0.94 668960.0 -269000.0 -1.35 664810.0 -122355.9375 -0.673606134945418 652690.0 -127007.0 -0.75783628179118 -1.8588 -0.9633 1954034 Maybridge1_005542 O=C1N(CCc2ccccn2)C(=O)c3ccc(Sc4ccccc4)c5cccc1c35 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D21 compound treatment 786290.0 -117000.0 -0.67 748520.0 -189000.0 -0.95 679910.0 -107255.9375 -0.590476105904728 616640.0 -163057.0 -0.972942519703831 -1.5895 -0.9784 1619211 Maybridge1_005543 COc1ccc(cc1)C2C(C(=O)O)c3ccccc3C(=O)N2C4CCN(Cc5ccccc5)CC4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D22 compound treatment 767770.0 -136000.0 -0.77 727480.0 -210000.0 -1.05 686080.0 -101085.9375 -0.556508405296711 628080.0 -151617.0 -0.904681344621425 -1.6439 -0.9763 1954035 Maybridge1_005544 Clc1ccccc1NCN2C(=O)c3ccccc3C2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D23 mock treatment 765710.0 -138000.0 -0.79 817470.0 -120000.0 -0.6 729170.0 -57995.9375 -0.31928503103424 754150.0 -25547.0 -0.152436034950194 -0.93 -0.8845 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 D24 mock treatment 950680.0 47400.0 0.27 797210.0 -141000.0 -0.7 815620.0 28454.0625 0.15664814847355 771150.0 -8547.0 -0.0509989740759896 -0.1637 -0.2121 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E01 compound treatment 848270.0 -55000.0 -0.31 953860.0 15900.0 0.08 791150.0 3984.0625 0.0219334590281406 960660.0 180963.0 1.07978557923404 0.4336 0.3845 1528809 Maybridge1_005545 Cc1c(sc2ccccc12)c3csc(n3)c4ccc(Cl)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E02 compound treatment 742460.0 -161000.0 -0.92 714150.0 -224000.0 -1.12 676580.0 -110585.9375 -0.608808754693172 501540.0 -278157.0 -1.65973109068153 -2.1532 -0.9423 1080143 Maybridge1_005546 CC(C)(O)C1(CC2CC3CC(C2)C1)C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E03 compound treatment 486350.0 -417000.0 -2.38 581990.0 -356000.0 -1.78 570150.0 -217015.9375 -1.19473782693162 433120.0 -346577.0 -2.06798542627053 -3.7123 -0.9734 1954036 Maybridge1_005547 O=C/1ON=C(CSc2ccccc2)\C1=C\c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E04 compound treatment 766990.0 -136000.0 -0.78 790620.0 -147000.0 -0.74 725130.0 -62035.9375 -0.341526442777577 645400.0 -134297.0 -0.801334880248412 -1.3291 -0.9623 1954037 Maybridge1_005548 Oc1c(c2ccccc2)c(=O)[nH]c3ccc(OC(F)(F)F)cc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E05 compound treatment 746640.0 -157000.0 -0.89 753030.0 -185000.0 -0.92 668050.0 -119115.9375 -0.655768963151257 642080.0 -137617.0 -0.821144941548551 -1.6482 -0.9921 1954038 Maybridge1_005549 CC(C)Oc1cccc(OCC(F)(F)F)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E06 compound treatment 743440.0 -160000.0 -0.91 725080.0 -213000.0 -1.06 627540.0 -159625.9375 -0.878788663577637 597300.0 -182397.0 -1.08834209366307 -1.9724 -0.9957 1954039 Maybridge1_005550 COc1ccc(Oc2ccc(cn2)C(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E07 compound treatment 1034170.0 131000.0 0.75 819690.0 -118000.0 -0.59 784480.0 -2685.9375 -0.0147868915481111 626420.0 -153277.0 -0.914586375271494 -0.3865 -0.2926 1954040 Maybridge1_005551 CS/C(=N\S(=O)(=O)c1ccccc1)/Nc2cccc(SC)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E08 compound treatment 725870.0 -177000.0 -1.01 719060.0 -219000.0 -1.09 632670.0 -154495.9375 -0.850546474903548 611060.0 -168637.0 -1.00623774321431 -1.9825 -0.9961 1954041 Maybridge1_005552 COc1cc(ccc1N2CCCCC2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E09 compound treatment 802140.0 -101000.0 -0.58 783040.0 -155000.0 -0.77 680800.0 -106365.9375 -0.585576388961271 624640.0 -155057.0 -0.925207432233617 -1.4316 -0.9803 1954042 Maybridge1_005553 COc1ccc(OC)c(c1)S(=O)(=O)/N=C(\Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)/SC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E10 compound treatment 756510.0 -147000.0 -0.84 794440.0 -143000.0 -0.72 695550.0 -91615.9375 -0.504373214898345 638610.0 -141087.0 -0.841850035738756 -1.4511 -0.9826 1954043 Maybridge1_005554 CC1CC2C3CC[C@H]4CC(O)CCC4(C)C3[C@H](O)CC2(C)[C@@]1(O)C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E11 compound treatment 737370.0 -166000.0 -0.95 763170.0 -175000.0 -0.87 662930.0 -124235.9375 -0.683956098825981 592190.0 -187507.0 -1.11883288078467 -1.8123 -0.9855 1954044 Maybridge1_005555 CCOC(=O)NC(=S)NCc1cccs1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E12 compound treatment 507430.0 -396000.0 -2.26 607080.0 -331000.0 -1.65 423840.0 -363325.9375 -2.00021826063648 449130.0 -330567.0 -1.97245558247077 -3.9443 -0.9941 1954045 Maybridge1_005556 CC12CCC3C(CCC4=CCCCC34)C2CCC1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E13 compound treatment 792320.0 -111000.0 -0.63 982110.0 44200.0 0.22 855130.0 67964.0625 0.37416254896346 769620.0 -10077.0 -0.060128309554668 -0.0494 -0.0641 1954046 Maybridge1_005557 CCOC(=O)NC(=S)N1CCSCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E14 compound treatment 644160.0 -259000.0 -1.48 673310.0 -265000.0 -1.32 505460.0 -281705.9375 -1.55087567982184 560280.0 -219417.0 -1.30923621093149 -2.8319 -0.9974 1954047 Maybridge1_005558 COc1cc(C)c2C3CCC4(C)C(CC[C@]4(C)O)C3CCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E15 compound treatment 730240.0 -173000.0 -0.99 718620.0 -219000.0 -1.1 640230.0 -146935.9375 -0.808926407383839 639780.0 -139917.0 -0.834868779196237 -1.8646 -0.9922 1126946 Maybridge1_005559 Nc1ccc(cc1)S(=O)(=O)Nc2nc(cc(n2)c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E16 compound treatment 728760.0 -175000.0 -1.0 754570.0 -183000.0 -0.92 656500.0 -130665.9375 -0.71935517741748 658910.0 -120787.0 -0.720722251283089 -1.677 -0.9896 1954048 Maybridge1_005560 C/C(=N\NC(=O)N)/c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E17 compound treatment 797140.0 -106000.0 -0.61 788700.0 -149000.0 -0.75 631680.0 -155485.9375 -0.855996721840653 667240.0 -112457.0 -0.671018091454729 -1.4398 -0.9918 1954049 Maybridge1_005561 OCc1cccc2cccc(Br)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E18 compound treatment 758410.0 -145000.0 -0.83 716680.0 -221000.0 -1.11 623290.0 -163875.9375 -0.902186188307632 588230.0 -191467.0 -1.14246174908243 -1.9894 -0.9912 1954050 Maybridge1_005562 CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E19 compound treatment 521510.0 -382000.0 -2.18 617250.0 -321000.0 -1.6 503530.0 -283635.9375 -1.56150090869922 632220.0 -147477.0 -0.87997843685559 -3.1131 -0.9588 1045906 Maybridge1_005563 COc1ccc(cc1)C(=O)c2ccc(OC)cc2OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E20 compound treatment 342360.0 -561000.0 -3.2 309150.0 -629000.0 -3.14 275940.0 -511225.9375 -2.81445212124032 316000.0 -463697.0 -2.76682710683446 -5.9652 -0.9979 1954051 Maybridge1_005564 N#C/C(=C\c1ccc2OCOc2c1)/c3ccccn3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E21 compound treatment 734760.0 -169000.0 -0.96 729880.0 -208000.0 -1.04 646120.0 -141045.9375 -0.776500190758033 651480.0 -128217.0 -0.76505621377105 -1.7724 -0.9911 1034241 Maybridge1_005565 CN(C)c1ccc(C=C(C#N)C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E22 compound treatment 760560.0 -143000.0 -0.82 707070.0 -231000.0 -1.15 704770.0 -82395.9375 -0.453614349484096 791490.0 11793.0 0.0703674858170289 -1.1766 -0.7917 1954052 Maybridge1_005566 Fc1ccc(cc1)C2CC(=NN2c3ccccc3)c4ccc(F)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E23 mock treatment 831650.0 -71600.0 -0.41 747680.0 -190000.0 -0.95 784650.0 -2515.9375 -0.0138509905589113 762980.0 -16717.0 -0.0997484321549454 -0.7372 -0.7083 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 E24 mock treatment 800250.0 -103000.0 -0.59 1009400.0 71500.0 0.36 749060.0 -38105.9375 -0.209784615297861 1020580.0 240883.0 1.43732138438594 0.4982 0.3099 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F01 compound treatment 732760.0 -171000.0 -0.97 737770.0 -200000.0 -1.0 739790.0 -47375.9375 -0.260818745708934 669570.0 -110127.0 -0.657115247229029 -1.4466 -0.924 1954053 Maybridge1_005567 OC(=O)c1cccnc1SC2CC(=O)N(C2=O)c3ccc(OC(F)(F)F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F02 compound treatment 707150.0 -196000.0 -1.12 745090.0 -193000.0 -0.96 684610.0 -102555.9375 -0.564601196203322 648590.0 -131107.0 -0.782300514119665 -1.7159 -0.972 1954054 Maybridge1_005568 COc1ccc([N+](=O)[O-])c(n1)N2CCOCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F03 compound treatment 667630.0 -236000.0 -1.35 680900.0 -257000.0 -1.29 608060.0 -179105.9375 -0.986031906340063 575280.0 -204417.0 -1.21973292192484 -2.4187 -0.9937 1236973 Maybridge1_005569 Cc1nc(NC(=O)c2cnccn2)ccc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F04 compound treatment 730240.0 -173000.0 -0.99 698410.0 -240000.0 -1.2 666350.0 -120815.9375 -0.665127973043255 645450.0 -134247.0 -0.801036535951724 -1.8263 -0.9767 1049203 Maybridge1_005570 OC(=O)c1onc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F05 compound treatment 729280.0 -174000.0 -0.99 722100.0 -216000.0 -1.08 666200.0 -120965.9375 -0.665953768033725 643380.0 -136317.0 -0.813387989834641 -1.7764 -0.9841 1252314 Maybridge1_005571 CC1=CCC2C(C1)C(=O)N(C2=O)c3ccc(F)cc3F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F06 compound treatment 773920.0 -129000.0 -0.74 756170.0 -182000.0 -0.91 687060.0 -100105.9375 -0.551113211358971 645460.0 -134237.0 -0.800976867092386 -1.5001 -0.9853 1954055 Maybridge1_005572 COc1ccc(cc1)/C(=C/c2ccc(OC)c(OC)c2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F07 compound treatment 746240.0 -157000.0 -0.9 782510.0 -155000.0 -0.78 680450.0 -106715.9375 -0.587503243939035 632910.0 -146787.0 -0.875861285561284 -1.5689 -0.9881 1954056 Maybridge1_005573 CSc1cccc(NC(=O)CC(CC(=O)O)c2ccc(cc2)C(F)(F)F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F08 compound treatment 755520.0 -148000.0 -0.84 807730.0 -130000.0 -0.65 700640.0 -86525.9375 -0.476351238221715 640280.0 -139417.0 -0.831885336229349 -1.4017 -0.9777 1333234 Maybridge1_005574 CCOc1ccc(NC(C(=O)Nc2ccc(OCC)cc2)c3ccccc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F09 compound treatment 785290.0 -118000.0 -0.67 801600.0 -136000.0 -0.68 683230.0 -103935.9375 -0.57219851011565 644960.0 -134737.0 -0.803960310059274 -1.366 -0.9928 1417585 Maybridge1_005575 OC(=O)CSCC(=O)NC1CCN(Cc2ccccc2)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F10 compound treatment 469290.0 -434000.0 -2.48 492750.0 -445000.0 -2.23 420190.0 -366975.9375 -2.02031260540459 385290.0 -394407.0 -2.35338158048308 -4.5397 -0.9972 1954057 Maybridge1_005576 COc1ccc(/C=C(\C#N)/c2cccc(Cl)c2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F11 compound treatment 862630.0 -40600.0 -0.23 769780.0 -168000.0 -0.84 674560.0 -112605.9375 -0.61992946056484 638600.0 -141097.0 -0.841909704598094 -1.2675 -0.9308 1954058 Maybridge1_005577 COc1ccc(/C=C/2\CCc3ccccc3C2=O)cc1OCc4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F12 compound treatment 471520.0 -432000.0 -2.47 453850.0 -484000.0 -2.42 394970.0 -392195.9375 -2.15915626980235 407310.0 -372387.0 -2.22199075222131 -4.6343 -0.9984 1954059 Maybridge1_005578 N#C/C(=C\c1ccccc1)/c2nc3ccccc3[nH]2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F13 compound treatment 735960.0 -167000.0 -0.96 880610.0 -57300.0 -0.29 627110.0 -160055.9375 -0.881155942550319 727120.0 -52577.0 -0.313720961740179 -1.2187 -0.8911 1137115 Maybridge1_005579 CC1=C(C)CC(C(C1)C(=O)O)C(=O)NCc2csc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F14 compound treatment 499120.0 -404000.0 -2.31 542170.0 -396000.0 -1.98 436970.0 -350195.9375 -1.92793367247063 397390.0 -382307.0 -2.28118226068438 -4.2486 -0.9967 1954060 Maybridge1_005580 Clc1ccccc1/C=C(\C#N)/c2nc3ccccc3[nH]2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F15 compound treatment 766630.0 -137000.0 -0.78 796550.0 -141000.0 -0.71 644320.0 -142845.9375 -0.786409730643678 600980.0 -178717.0 -1.06638395342677 -1.6702 -0.9868 1449572 Maybridge1_005581 Cc1cc(ccc1Br)N2C(SCC2=O)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F16 compound treatment 790670.0 -113000.0 -0.64 731270.0 -207000.0 -1.03 653800.0 -133365.9375 -0.734219487245947 633050.0 -146647.0 -0.875025921530555 -1.6431 -0.9842 1083206 Maybridge1_005582 O=C1N(CCCCCCCCN2C(=O)c3cccc4cccc(C2=O)c34)C(=O)c5cccc6cccc1c56 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F17 compound treatment 743360.0 -160000.0 -0.91 713010.0 -225000.0 -1.12 627740.0 -159425.9375 -0.877687603590343 565340.0 -214357.0 -1.27904376810658 -2.0976 -0.9881 1590174 Maybridge1_005583 O=C(NC(=S)Nc1ccc2CCCc2c1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F18 compound treatment 36970.0 -866000.0 -4.95 38420.0 -900000.0 -4.5 31930.0 -755235.9375 -4.15780035873825 23390.0 -756307.0 -4.51279759991687 -9.0592 -0.9981 1924086 Maybridge1_005584 [O-][N+](=O)c1ccc2C(=O)N(Cc3cccnc3)C(=O)c4cccc1c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F19 compound treatment 764030.0 -139000.0 -0.8 771920.0 -166000.0 -0.83 621450.0 -165715.9375 -0.912315940190736 632920.0 -146777.0 -0.875801616701946 -1.7069 -0.9987 1464771 Maybridge1_005585 Cn1c2NCN(Cc3ccc4OCOc4c3)Cc2c(=O)n(C)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F20 compound treatment 659320.0 -244000.0 -1.39 633600.0 -304000.0 -1.52 566920.0 -220245.9375 -1.21251994572642 461760.0 -317937.0 -1.89709381312717 -3.0127 -0.9864 1954061 Maybridge1_005586 OCCSc1ccc2C(=O)N(CCc3ccccn3)C(=O)c4cccc1c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F21 compound treatment 755930.0 -147000.0 -0.84 778330.0 -160000.0 -0.8 655410.0 -131755.9375 -0.725355954348232 642320.0 -137377.0 -0.819712888924445 -1.5925 -0.9985 1621297 Maybridge1_005587 NC(=O)C1CCN(CC1)C(=O)CCC(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F22 compound treatment 790260.0 -113000.0 -0.65 784980.0 -153000.0 -0.77 685400.0 -101765.9375 -0.560252009253511 655740.0 -123957.0 -0.739637279693161 -1.3552 -0.9929 1083101 Maybridge1_005588 Clc1cccc(NCN2C(=O)c3ccccc3C2=O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F23 mock treatment 927100.0 23800.0 0.14 882780.0 -55200.0 -0.28 755080.0 -32085.9375 -0.176642709680315 724040.0 -55657.0 -0.332098970416211 -0.3242 -0.6673 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 F24 mock treatment 830520.0 -72800.0 -0.42 834950.0 -103000.0 -0.52 773470.0 -13695.9375 -0.0754002438486405 760180.0 -19517.0 -0.11645571276952 -0.5613 -0.83 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G01 compound treatment 864030.0 -39200.0 -0.22 829700.0 -108000.0 -0.54 849390.0 62224.0625 0.342562127328125 813700.0 34003.0 0.20289202240621 -0.11 -0.1553 1679514 Maybridge1_005589 Cc1c(sc2ccccc12)C(=O)c3ccccc3C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G02 compound treatment 773370.0 -130000.0 -0.74 770080.0 -168000.0 -0.84 720070.0 -67095.9375 -0.369383260456113 649380.0 -130317.0 -0.777586674231981 -1.3643 -0.9655 1954062 Maybridge1_005590 OC(=O)C1(CC2CC3CC(Br)(C2)C1)C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G03 compound treatment 729690.0 -174000.0 -0.99 673230.0 -265000.0 -1.32 614940.0 -172225.9375 -0.948155442777153 615410.0 -164287.0 -0.980281789402376 -2.122 -0.9898 1954063 Maybridge1_005591 Clc1ccc(/C=C/2\C(=O)ON=C2CSc3ccccc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G04 compound treatment 720870.0 -182000.0 -1.04 752910.0 -185000.0 -0.93 666560.0 -120605.9375 -0.663971860056596 623950.0 -155747.0 -0.929324583527923 -1.7803 -0.9881 1080145 Maybridge1_005592 CCOC(=O)C1(CCC2(CC1=O)C(=O)OCC)CC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G05 compound treatment 710620.0 -193000.0 -1.1 840550.0 -97400.0 -0.49 651370.0 -135795.9375 -0.747597366091568 561280.0 -218417.0 -1.30326932499771 -1.8192 -0.945 1512628 Maybridge1_005593 Fc1cccc(Oc2ccccc2)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G06 compound treatment 727290.0 -176000.0 -1.01 728040.0 -210000.0 -1.05 600270.0 -186895.9375 -1.02891819284516 586160.0 -193537.0 -1.15481320296535 -2.1194 -0.9986 1038289 Maybridge1_005594 CC(=O)CCc1c[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G07 compound treatment 705120.0 -198000.0 -1.13 778620.0 -159000.0 -0.8 618600.0 -168565.9375 -0.928006045009674 643880.0 -135817.0 -0.810404546867753 -1.8336 -0.9894 1954064 Maybridge1_005595 Clc1cccc(N/C(=N\S(=O)(=O)c2ccccc2)/NCCc3ccccc3)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G08 compound treatment 655370.0 -248000.0 -1.42 656160.0 -282000.0 -1.41 531060.0 -256105.9375 -1.40994000144822 496700.0 -282997.0 -1.68861081860101 -2.962 -0.9967 1954065 Maybridge1_005596 CN(C1CCCCC1)c2ccc(cc2Cl)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G09 compound treatment 774410.0 -129000.0 -0.74 816070.0 -122000.0 -0.61 651650.0 -135515.9375 -0.746055882109357 654180.0 -125517.0 -0.748945621749853 -1.4203 -0.9966 1954066 Maybridge1_005597 COc1ccc(OC)c(c1)S(=O)(=O)/N=C(/NCC(C)C)\SC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G10 compound treatment 794650.0 -109000.0 -0.62 774820.0 -163000.0 -0.82 695200.0 -91965.9375 -0.506300069876109 680570.0 -99127.0 -0.591479501957485 -1.2671 -0.9844 1954067 Maybridge1_005598 C[C@]1(O)CCC2C3CC[C@@]4(C)CC(=O)/C(=C/c5ccccc5)/CC4(C)C3CCC21C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G11 compound treatment 782320.0 -121000.0 -0.69 807130.0 -131000.0 -0.65 662440.0 -124725.9375 -0.686653695794851 689510.0 -90187.0 -0.538135541709521 -1.285 -0.9954 1954068 Maybridge1_005599 CN(N)C(=S)NC(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G12 compound treatment 528530.0 -375000.0 -2.14 390960.0 -547000.0 -2.74 393950.0 -393215.9375 -2.16477167573755 325760.0 -453937.0 -2.7085903001208 -4.8749 -0.9932 1954069 Maybridge1_005600 COc1ccc2C3C(C)CC4(C)C(CC[C@@]4(O)C#C)C3CCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G13 compound treatment 707370.0 -196000.0 -1.12 953970.0 16000.0 0.08 651520.0 -135645.9375 -0.746771571101098 800090.0 20393.0 0.121682704847509 -0.832 -0.6148 1954070 Maybridge1_005601 [O-][N+](=O)c1ccc(CNCc2ccc(cc2)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G14 compound treatment 782260.0 -121000.0 -0.69 809790.0 -128000.0 -0.64 651600.0 -135565.9375 -0.74633114710618 684600.0 -95097.0 -0.567432951644365 -1.323 -0.9951 1518209 Maybridge1_005602 O=C(Nc1ccncc1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G15 compound treatment 634640.0 -269000.0 -1.53 699580.0 -238000.0 -1.19 593150.0 -194015.9375 -1.06811592839282 581280.0 -198417.0 -1.18393160632218 -2.4894 -0.9903 1954071 Maybridge1_005603 Nc1oc(c2ccco2)c(c1C#N)c3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G16 compound treatment 705290.0 -198000.0 -1.13 729200.0 -209000.0 -1.04 563270.0 -223895.9375 -1.23261429049453 592180.0 -187517.0 -1.11889254964401 -2.2632 -0.9982 1019776 Maybridge1_005604 NNC(=O)c1ccc(o1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G17 compound treatment 798330.0 -105000.0 -0.6 728270.0 -210000.0 -1.05 654720.0 -132445.9375 -0.729154611304396 599300.0 -180397.0 -1.07640832179552 -1.7268 -0.9731 1625004 Maybridge1_005605 OC(=O)Cc1ccccc1I 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G18 compound treatment 524930.0 -378000.0 -2.16 521450.0 -416000.0 -2.08 426350.0 -360815.9375 -1.98639995779594 439440.0 -340257.0 -2.03027470716907 -4.1305 -0.9995 1954072 Maybridge1_005606 CN(C)/C=C/C=C\1/C(=O)c2cccc3cccc1c23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G19 compound treatment 25770.0 -878000.0 -5.01 30840.0 -907000.0 -4.54 23760.0 -763405.9375 -4.2027786592192 15320.0 -764377.0 -4.56095036940245 -9.1567 -0.998 1954073 Maybridge1_005607 COc1cc(N=Nc2c(Cl)cc(cc2[N+](=O)[O-])[N+](=O)[O-])c(NC(=O)C)cc1N(CCO)CCC#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G20 compound treatment 281960.0 -621000.0 -3.55 370510.0 -567000.0 -2.84 359320.0 -427845.9375 -2.35542021253749 255840.0 -523857.0 -3.12579496461047 -5.9342 -0.9895 1954074 Maybridge1_005608 N#C/C(=C\c1ccc(C#N)cc1)/c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G21 compound treatment 499200.0 -404000.0 -2.31 467920.0 -470000.0 -2.35 355590.0 -431575.9375 -2.37595498130052 398690.0 -381007.0 -2.27342530897047 -4.6542 -0.9999 1954075 Maybridge1_005609 C/C(=C\c1ccc(Cl)cc1)/C(=N/O)/C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G22 compound treatment 193510.0 -710000.0 -4.05 163010.0 -775000.0 -3.88 96060.0 -691105.9375 -3.80474547381246 156490.0 -623207.0 -3.71860508213119 -7.7268 -0.9995 1954076 Maybridge1_005610 CN(C)/C=C/1\Cc2ccccc2C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G23 mock treatment 811040.0 -92200.0 -0.53 779810.0 -158000.0 -0.79 679560.0 -107605.9375 -0.592402960882493 677140.0 -102557.0 -0.611945920710339 -1.261 -0.9882 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 G24 mock treatment 899680.0 -3590.0 -0.02 1087240.0 149000.0 0.75 777060.0 -10105.9375 -0.0556362170767149 703290.0 -76407.0 -0.455911853542078 0.1073 0.1224 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H01 compound treatment 628990.0 -274000.0 -1.57 685220.0 -253000.0 -1.26 576450.0 -210715.9375 -1.16005443733186 581440.0 -198257.0 -1.18297690457277 -2.5869 -0.9922 1223060 Maybridge1_005611 OC(=O)CC(CC(=O)Oc1ccccc1N2CCCC2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H02 compound treatment 764820.0 -138000.0 -0.79 803620.0 -134000.0 -0.67 794200.0 7034.0625 0.0387246238343726 697980.0 -81717.0 -0.487596017850432 -0.9558 -0.8331 1602597 Maybridge1_005612 CCOC(=O)Cc1csc(NC(=O)CSCC(=O)O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H03 compound treatment 722570.0 -181000.0 -1.03 708260.0 -230000.0 -1.15 616960.0 -170205.9375 -0.937034736905484 601000.0 -178697.0 -1.0662646157081 -2.0921 -0.9974 1125333 Maybridge1_005613 CCOC(=O)Nc1cc(OC)c(OC)cc1C(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H04 compound treatment 781850.0 -121000.0 -0.69 758320.0 -180000.0 -0.9 647200.0 -139965.9375 -0.770554466826646 587900.0 -191797.0 -1.14443082144057 -1.7535 -0.9815 1954077 Maybridge1_005614 Cc1cc(C)c(NC(=O)N)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H05 compound treatment 701830.0 -201000.0 -1.15 746150.0 -192000.0 -0.96 639730.0 -147435.9375 -0.811679057352074 625130.0 -154567.0 -0.922283658126067 -1.922 -0.992 1183506 Maybridge1_005615 CC1=CCC2C(C1)C(=O)N(C2=O)c3ccc(Br)c(C)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H06 compound treatment 741760.0 -162000.0 -0.92 897760.0 -40200.0 -0.2 634430.0 -152735.9375 -0.840857147015362 644370.0 -135327.0 -0.807480772760202 -1.386 -0.9238 1954078 Maybridge1_005616 Oc1ccc(/C=C(\C#N)/c2ccc(cc2)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H07 compound treatment 777020.0 -126000.0 -0.72 1059940.0 122000.0 0.61 671680.0 -115485.9375 -0.635784724381873 718180.0 -61517.0 -0.367064921988143 -0.5569 -0.4655 1954079 Maybridge1_005617 OC(=O)CC(CC(=O)NCc1ccco1)c2ccc(cc2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H08 compound treatment 631230.0 -272000.0 -1.55 739730.0 -198000.0 -0.99 580000.0 -207165.9375 -1.1405106225574 604870.0 -174827.0 -1.04317276714438 -2.3645 -0.9829 1954080 Maybridge1_005618 OCCN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H09 compound treatment 726910.0 -176000.0 -1.01 903930.0 -34000.0 -0.17 624320.0 -162845.9375 -0.896515729373069 679850.0 -99847.0 -0.595775659829804 -1.3349 -0.8995 1954081 Maybridge1_005619 OCC1(CO)CSC(=N1)Nc2ccc(I)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H10 compound treatment 676290.0 -227000.0 -1.3 717830.0 -220000.0 -1.1 577280.0 -209885.9375 -1.15548503838459 598020.0 -181677.0 -1.08404593579075 -2.3185 -0.9974 1954082 Maybridge1_005620 Clc1cccc(c1)/C(=C/c2ccccc2Cl)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H11 compound treatment 785830.0 -117000.0 -0.67 792350.0 -146000.0 -0.73 669120.0 -118045.9375 -0.649878292219234 617330.0 -162367.0 -0.968825368409525 -1.5089 -0.9861 1604955 Maybridge1_005621 NS(=O)(=O)c1ccc(cc1)n2ncc3ccccc3c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H12 compound treatment 686180.0 -217000.0 -1.24 593540.0 -344000.0 -1.72 524860.0 -262305.9375 -1.44407286105433 536880.0 -242817.0 -1.44886134178186 -2.9278 -0.9932 1776302 Maybridge1_005622 N#C/C(=C\C=C\c1ccccc1)/c2nc3ccccc3[nH]2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H13 compound treatment 755060.0 -148000.0 -0.85 1036560.0 98600.0 0.49 650900.0 -136265.9375 -0.750184857061709 615360.0 -164337.0 -0.980580133699065 -1.0421 -0.6611 1954083 Maybridge1_005623 O=C1N(CN(CCSc2ccccc2)CN3C(=O)c4ccccc4C3=O)C(=O)c5ccccc15 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H14 compound treatment 793880.0 -109000.0 -0.62 814080.0 -124000.0 -0.62 673770.0 -113395.9375 -0.624278647514651 643920.0 -135777.0 -0.810165871430402 -1.3394 -0.9927 1676681 Maybridge1_005624 Clc1cc(Cl)c2oc(=O)c(cc2c1)c3nc4ccccc4[nH]3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H15 compound treatment 559200.0 -344000.0 -1.97 578350.0 -360000.0 -1.8 448390.0 -338775.9375 -1.86506314719615 460930.0 -318767.0 -1.9020463284522 -3.7655 -0.9995 1954084 Maybridge1_005625 CCOC(=O)CSC(=S)NCc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H16 compound treatment 757710.0 -146000.0 -0.83 854260.0 -83700.0 -0.42 711960.0 -75205.9375 -0.41403124294088 649280.0 -130417.0 -0.778183362825359 -1.2211 -0.9525 1954085 Maybridge1_005626 O=C1N(CC2CCCO2)C(=O)c3cccc4cccc1c34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H17 compound treatment 774920.0 -128000.0 -0.73 1010200.0 72300.0 0.36 644910.0 -142255.9375 -0.783161603681161 629850.0 -149847.0 -0.89411995651864 -1.0245 -0.7102 1587112 Maybridge1_005627 COc1ccc(cc1)C2C(C(=O)O)c3ccccc3C(=O)N2Cc4ccc(F)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H18 compound treatment 694720.0 -209000.0 -1.19 700160.0 -238000.0 -1.19 610940.0 -176225.9375 -0.970176642523031 579480.0 -200217.0 -1.19467200100297 -2.2727 -0.9965 1954086 Maybridge1_005628 [O-][N+](=O)c1cc2C(=O)N(CCc3ccccn3)C(=O)c4cccc(c1)c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H19 compound treatment 763200.0 -140000.0 -0.8 876550.0 -61400.0 -0.31 643960.0 -143205.9375 -0.788391638620808 649800.0 -129897.0 -0.775080582139795 -1.3353 -0.9546 1954087 Maybridge1_005629 CC(=O)Nc1cccc(OCCCN2CNc3c(C2)c(=O)n(C)c(=O)n3C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H20 compound treatment 623630.0 -280000.0 -1.6 667480.0 -270000.0 -1.35 540640.0 -246525.9375 -1.35719922805684 552990.0 -226707.0 -1.35273480938872 -2.83 -0.9972 1169131 Maybridge1_005630 CCSc1ccc2C(=O)N(NCCO)C(=O)c3cccc1c32 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H21 compound treatment 762530.0 -141000.0 -0.8 769280.0 -169000.0 -0.84 670330.0 -116835.9375 -0.643216879296106 635580.0 -144117.0 -0.8599297001181 -1.5753 -0.9941 1954088 Maybridge1_005631 COc1ccc(/C=C\2/N=C(OC2=O)c3ccccc3)cc1OC4CCCC4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H22 compound treatment 784100.0 -119000.0 -0.68 765070.0 -173000.0 -0.86 650400.0 -136765.9375 -0.752937507029944 622400.0 -157297.0 -0.938573256725277 -1.6184 -0.9926 1954089 Maybridge1_005632 Clc1ccccc1CC2=NCCN2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H23 mock treatment 886180.0 -17100.0 -0.1 789380.0 -149000.0 -0.74 738470.0 -48695.9375 -0.268085741625074 692800.0 -86897.0 -0.518504486987396 -0.8136 -0.8565 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 H24 mock treatment 873730.0 -29500.0 -0.17 1095140.0 157000.0 0.79 772320.0 -14845.9375 -0.0817313387755804 711360.0 -68337.0 -0.4077590840565 0.064 0.0707 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I01 compound treatment 826030.0 -77200.0 -0.44 705820.0 -232000.0 -1.16 707680.0 -79485.9375 -0.43759392666897 779840.0 143.0 8.53264688530071E-4 -1.0195 -0.7742 1323676 Maybridge1_005633 CCOC(=O)c1csc(n1)c2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I02 compound treatment 809120.0 -94200.0 -0.54 766800.0 -171000.0 -0.86 701730.0 -85435.9375 -0.470350461290964 676960.0 -102737.0 -0.613019960178419 -1.2386 -0.9734 1954090 Maybridge1_005634 OC(=O)C1(CC2CC3CC(Cl)(C2)C1)C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I03 compound treatment 770140.0 -133000.0 -0.76 736320.0 -202000.0 -1.01 652640.0 -134525.9375 -0.740605635172252 614400.0 -165297.0 -0.986308344195491 -1.7479 -0.9901 1954091 Maybridge1_005635 CCCS(=O)(=O)c1ccc(cc1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I04 compound treatment 761670.0 -142000.0 -0.81 627360.0 -311000.0 -1.55 620800.0 -166365.9375 -0.915894385149441 554350.0 -225347.0 -1.34461984451878 -2.3114 -0.9669 1954092 Maybridge1_005636 C1C2CC3CC1CC(C2)(C3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I05 compound treatment 719110.0 -184000.0 -1.05 769840.0 -168000.0 -0.84 681600.0 -105565.9375 -0.581172149012095 610660.0 -169037.0 -1.00862449758782 -1.7413 -0.9782 1716781 Maybridge1_005637 Fc1ccc(Oc2cccc(F)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I06 compound treatment 789180.0 -114000.0 -0.65 792010.0 -146000.0 -0.73 640480.0 -146685.9375 -0.807550082399721 641760.0 -137937.0 -0.82305434504736 -1.5061 -0.9959 1954093 Maybridge1_005638 Cc1ccc(cc1)S(=O)(=O)Oc2cc(=O)n(C)c3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I07 compound treatment 807890.0 -95400.0 -0.54 787730.0 -150000.0 -0.75 705140.0 -82025.9375 -0.451577388507602 648430.0 -131267.0 -0.783255215869069 -1.2655 -0.9767 1954094 Maybridge1_005639 COc1ccc(cc1CS/C(=N\S(=O)(=O)c2ccccc2)/Nc3cccc(Cl)c3Cl)C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I08 compound treatment 449790.0 -453000.0 -2.59 458290.0 -480000.0 -2.4 389860.0 -397305.9375 -2.18728835247771 376080.0 -403617.0 -2.40833659993316 -4.7926 -0.9982 1954095 Maybridge1_005640 CC12CCC3C(CC4OCC53CCC(O)C[C@]45Br)C2CCC1OC(=O)c6ccccc6 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I09 compound treatment 763070.0 -140000.0 -0.8 793850.0 -144000.0 -0.72 648590.0 -138575.9375 -0.762902099914954 643450.0 -136247.0 -0.812970307819277 -1.5487 -0.9989 1954096 Maybridge1_005641 COc1ccc(OC)c(c1)S(=O)(=O)Nc2ccc(C#N)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I10 compound treatment 592850.0 -310000.0 -1.77 673210.0 -265000.0 -1.32 572000.0 -215165.9375 -1.18455302204915 518580.0 -261117.0 -1.55805535436998 -2.92 -0.9884 1954097 Maybridge1_005642 C[C@]1(O)CCC2C3CC[C@H]4CC5(CCC4(C)C3CCC21C)OCCO5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I11 compound treatment 728360.0 -175000.0 -1.0 866620.0 -71300.0 -0.36 620920.0 -166245.9375 -0.915233749157065 615520.0 -164177.0 -0.979625431949661 -1.6254 -0.9507 1954098 Maybridge1_005643 CCOC(=O)NC(=S)NCCc1ccccn1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I12 compound treatment 664590.0 -239000.0 -1.36 614270.0 -324000.0 -1.62 566040.0 -221125.9375 -1.21736460967051 548930.0 -230767.0 -1.37696036627985 -2.7883 -0.9947 1588046 Maybridge1_005644 CC1CC2(C)C(O)CCC2C3CCc4cc(O)ccc4C13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I13 compound treatment 755140.0 -148000.0 -0.85 947360.0 9430.0 0.05 712160.0 -75005.9375 -0.412930182953586 619840.0 -159857.0 -0.953848484715745 -1.0829 -0.8075 1954099 Maybridge1_005645 CC(C)(C)c1ccc(NC(=O)CSCC(=O)NN)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I14 compound treatment 476160.0 -427000.0 -2.44 408060.0 -530000.0 -2.65 391880.0 -395285.9375 -2.17616764660604 307270.0 -472427.0 -2.81891802103633 -5.0426 -0.9955 1136690 Maybridge1_005646 Sc1nnc2nc3c4ccccc4c5ccccc5c3nn12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I15 compound treatment 683690.0 -220000.0 -1.25 823580.0 -114000.0 -0.57 594010.0 -193155.9375 -1.06338137044746 665920.0 -113777.0 -0.678894380887314 -1.7843 -0.9548 1004303 Maybridge1_005647 CCOC(=O)C1=C(C)NC(=C(C1)C(=O)OCC)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I16 compound treatment 861140.0 -42100.0 -0.24 821840.0 -116000.0 -0.58 672030.0 -115135.9375 -0.633857869404108 623650.0 -156047.0 -0.931114649308056 -1.1932 -0.925 1083242 Maybridge1_005648 CSC(=N)Nc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I17 compound treatment 779220.0 -124000.0 -0.71 788160.0 -150000.0 -0.75 684740.0 -102425.9375 -0.563885507211581 621280.0 -158417.0 -0.945256168971107 -1.4834 -0.9836 1954100 Maybridge1_005649 CC(=O)NCc1ccccc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I18 compound treatment 699720.0 -204000.0 -1.16 691750.0 -246000.0 -1.23 685920.0 -101245.9375 -0.557389253286547 562480.0 -217217.0 -1.29610906187718 -2.1238 -0.9635 1954101 Maybridge1_005650 O=C/1CCCC\C1=C/Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I19 compound treatment 793920.0 -109000.0 -0.62 711260.0 -227000.0 -1.13 687400.0 -99765.9375 -0.549241409380572 643550.0 -136147.0 -0.812373619225899 -1.56 -0.9606 1050798 Maybridge1_005651 [O-][N+](=O)c1cnc2ccccn12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I20 compound treatment 643700.0 -260000.0 -1.48 677840.0 -260000.0 -1.3 535360.0 -251805.9375 -1.3862672117214 546730.0 -232967.0 -1.39008751533416 -2.78 -0.9989 1954102 Maybridge1_005652 N#C/C(=C/c1cccs1)/c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I21 compound treatment 807330.0 -95900.0 -0.55 735200.0 -203000.0 -1.01 634930.0 -152235.9375 -0.838104497047127 632020.0 -147677.0 -0.881171814042345 -1.6407 -0.9792 1954103 Maybridge1_005653 COc1ccc(/C=N/c2nc3ccccc3[nH]2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I22 compound treatment 213920.0 -689000.0 -3.94 431790.0 -506000.0 -2.53 92860.0 -694305.9375 -3.82236243360916 199640.0 -580057.0 -3.46113395408872 -6.8765 -0.9873 1954104 Maybridge1_005654 [O-][N+](=O)C1Cc2ccccc2C(=O)O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I23 mock treatment 841680.0 -61600.0 -0.35 929760.0 -8170.0 -0.04 670620.0 -116545.9375 -0.64162034231453 711000.0 -68697.0 -0.409907162992659 -0.7221 -0.8599 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 I24 mock treatment 990270.0 87000.0 0.5 1114470.0 177000.0 0.88 756220.0 -30945.9375 -0.17036666775274 766630.0 -13067.0 -0.0779692984966604 0.5658 0.5491 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J01 compound treatment 764270.0 -139000.0 -0.79 625960.0 -312000.0 -1.56 624710.0 -162455.9375 -0.894368662397846 666370.0 -113327.0 -0.676209282217115 -1.9625 -0.9439 1190021 Maybridge1_005655 OC(=O)CC(CC(=O)Nc1ccc(Oc2ccc(Cl)cc2)cc1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J02 compound treatment 719490.0 -184000.0 -1.05 692060.0 -246000.0 -1.23 661770.0 -125395.9375 -0.690342246752285 612770.0 -166927.0 -0.996034368267547 -1.983 -0.9813 1954105 Maybridge1_005656 COc1ccc(CC(=O)NNC(=S)NCC2CC2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J03 compound treatment 627070.0 -276000.0 -1.58 681310.0 -257000.0 -1.28 588110.0 -199055.9375 -1.09586264007263 628040.0 -151657.0 -0.904920020058776 -2.4311 -0.9798 1145439 Maybridge1_005657 O=C(Nc1ccc2OCCOc2c1)c3cnccn3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J04 compound treatment 633600.0 -270000.0 -1.54 618620.0 -319000.0 -1.6 563250.0 -223915.9375 -1.23272439649326 567890.0 -211807.0 -1.26382820897545 -2.8171 -0.9935 1954106 Maybridge1_005658 Cc1ccc(cc1)/C(=C/c2ccco2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J05 compound treatment 738690.0 -165000.0 -0.94 774590.0 -163000.0 -0.82 651870.0 -135295.9375 -0.744844716123334 668640.0 -111057.0 -0.662664451147441 -1.5823 -0.9918 1353715 Maybridge1_005659 CC1=CCC2C(C1)C(=O)N(C2=O)c3ccc4OCOc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J06 compound treatment 759580.0 -144000.0 -0.82 787610.0 -150000.0 -0.75 649730.0 -137435.9375 -0.756626057987378 630370.0 -149327.0 -0.891017175833076 -1.6102 -0.9975 1954107 Maybridge1_005660 CC(Cc1ccc(cc1)C(C)(C)C)/C=C(\C#N)/c2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J07 compound treatment 687940.0 -215000.0 -1.23 714560.0 -223000.0 -1.12 613890.0 -173275.9375 -0.953936007710446 590240.0 -189457.0 -1.13046830835554 -2.2159 -0.996 1954108 Maybridge1_005661 Fc1cc(I)ccc1N2C(=O)CC(CC2=O)c3ccc(cc3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J08 compound treatment 719280.0 -184000.0 -1.05 703000.0 -235000.0 -1.18 639490.0 -147675.9375 -0.813000329336826 624000.0 -155697.0 -0.929026239231234 -1.9841 -0.9909 1954109 Maybridge1_005662 COc1ccc(CCN2C(=O)c3cccc4cc(cc(C2=O)c34)[N+](=O)[O-])cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J09 compound treatment 743320.0 -160000.0 -0.91 772320.0 -166000.0 -0.83 655520.0 -131645.9375 -0.72475037135522 627170.0 -152527.0 -0.910111210821162 -1.6885 -0.9959 1075870 Maybridge1_005663 CNC(=O)Nc1ccc(C)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J10 compound treatment 782960.0 -120000.0 -0.69 752100.0 -186000.0 -0.93 635270.0 -151895.9375 -0.836232695068728 634400.0 -145297.0 -0.866970625519956 -1.66 -0.9943 1954110 Maybridge1_005664 CCOc1ccccc1/C=C(\C#N)/c2cccc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J11 compound treatment 705710.0 -198000.0 -1.13 725080.0 -213000.0 -1.06 573020.0 -214145.9375 -1.17893761611395 593440.0 -186257.0 -1.11137427336745 -2.2417 -0.9993 1954111 Maybridge1_005665 [O-][N+](=O)c1ccc(SCc2c(F)cccc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J12 compound treatment 622810.0 -280000.0 -1.6 607430.0 -331000.0 -1.65 503130.0 -284035.9375 -1.56370302867381 482680.0 -297017.0 -1.77226655939256 -3.2956 -0.9989 1954112 Maybridge1_005666 Oc1ccc(/C=C(\C#N)/c2nc3ccccc3[nH]2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J13 compound treatment 889410.0 -13900.0 -0.08 803250.0 -135000.0 -0.67 633030.0 -154135.9375 -0.848564566926419 579060.0 -200637.0 -1.19717809309516 -1.3993 -0.8656 1200713 Maybridge1_005667 Nc1nc(cs1)c2csc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J14 compound treatment 762780.0 -140000.0 -0.8 743520.0 -194000.0 -0.97 587070.0 -200095.9375 -1.10158815200656 637320.0 -142377.0 -0.849547318593328 -1.863 -0.9923 1954113 Maybridge1_005668 Cc1ccc(cc1)/C(=C/c2cccc(c2)[N+](=O)[O-])/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J15 compound treatment 706960.0 -196000.0 -1.12 807400.0 -131000.0 -0.65 647760.0 -139405.9375 -0.767471498862223 679090.0 -100607.0 -0.600310493139475 -1.571 -0.9682 1355512 Maybridge1_005669 CN1CCC2(CC1)Nc3ccccc3S2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J16 compound treatment 757570.0 -146000.0 -0.83 871200.0 -66700.0 -0.33 669850.0 -117315.9375 -0.645859423265612 679940.0 -99757.0 -0.595238640095764 -1.2036 -0.9589 1954114 Maybridge1_005670 O=C1N(Cc2ccco2)C(=O)c3cccc4cccc1c34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J17 compound treatment 840480.0 -62800.0 -0.36 843400.0 -94500.0 -0.47 696480.0 -90685.9375 -0.499253285957429 660000.0 -119697.0 -0.714218345615272 -1.0225 -0.9698 1527417 Maybridge1_005671 OC(=O)C1C(N(Cc2ccc(F)cc2)C(=O)c3ccccc13)c4ccncc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J18 compound treatment 845300.0 -58000.0 -0.33 724170.0 -214000.0 -1.07 580240.0 -206925.9375 -1.13918935057264 727440.0 -52257.0 -0.31181155824137 -1.4257 -0.8762 1954115 Maybridge1_005672 [O-][N+](=O)c1cc2C(=O)N(Cc3cccnc3)C(=O)c4cccc(c1)c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J19 compound treatment 731960.0 -171000.0 -0.98 689130.0 -249000.0 -1.24 639310.0 -147855.9375 -0.813991283325391 633930.0 -145767.0 -0.869775061908831 -1.9534 -0.9859 1394250 Maybridge1_005673 CCCSc1ncccc1C(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J20 compound treatment 747070.0 -156000.0 -0.89 807490.0 -130000.0 -0.65 653490.0 -133675.9375 -0.735926130226253 730570.0 -49127.0 -0.293135205268649 -1.2869 -0.9463 1954116 Maybridge1_005674 CCSc1ccc2C(=O)N(Cc3ccccc3)C(=O)c4cccc1c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J21 compound treatment 739840.0 -163000.0 -0.93 792490.0 -145000.0 -0.73 650450.0 -136715.9375 -0.75266224203312 683890.0 -95807.0 -0.571669440657346 -1.4927 -0.9855 1456671 Maybridge1_005675 CCCCC1(C2CC(=O)N(C2=O)c3cc(F)ccc3F)C(=O)N(N(C1=O)c4ccccc4)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J22 compound treatment 839410.0 -63900.0 -0.36 713460.0 -224000.0 -1.12 646250.0 -140915.9375 -0.775784501766292 600160.0 -179537.0 -1.07127679989247 -1.6673 -0.9405 1954117 Maybridge1_005676 Cc1cccnc1NC(=S)Nc2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J23 mock treatment 922120.0 18800.0 0.11 936160.0 -1770.0 -0.01 714000.0 -73165.9375 -0.402800431070483 702600.0 -77097.0 -0.460029004836384 -0.382 -0.6152 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 J24 mock treatment 973710.0 70400.0 0.4 1060340.0 122000.0 0.61 765830.0 -21335.9375 -0.117460735363268 751360.0 -28337.0 -0.169083646705431 0.364 0.4784 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K01 compound treatment 844880.0 -58400.0 -0.33 820290.0 -118000.0 -0.59 804920.0 17754.0625 0.0977414391533258 776520.0 -3177.0 -0.0189567966116086 -0.4216 -0.6167 1954118 Maybridge1_005677 OCC/N=C/c1c[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K02 compound treatment 797980.0 -105000.0 -0.6 749930.0 -188000.0 -0.94 656670.0 -130495.9375 -0.71841927642828 676280.0 -103417.0 -0.617077442613387 -1.4386 -0.9828 1246291 Maybridge1_005678 CCCCn1c(=O)c(c(O)c2ccccc12)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K03 compound treatment 662240.0 -241000.0 -1.38 689090.0 -249000.0 -1.24 617500.0 -169665.9375 -0.934061874939791 573090.0 -206607.0 -1.23280040211981 -2.3942 -0.991 1473368 Maybridge1_005679 COc1cccc(OCc2ccccc2)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K04 compound treatment 758490.0 -145000.0 -0.83 731300.0 -207000.0 -1.03 632700.0 -154465.9375 -0.850381315905454 665920.0 -113777.0 -0.678894380887314 -1.6949 -0.9891 1508064 Maybridge1_005680 Cc1ccc2[nH]c(=O)c(c(O)c2c1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K05 compound treatment 801120.0 -102000.0 -0.58 759970.0 -178000.0 -0.89 695440.0 -91725.9375 -0.504978797891357 651260.0 -128437.0 -0.766368928676481 -1.3725 -0.9766 1954119 Maybridge1_005681 Cc1ccc(Oc2cccc(F)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K06 compound treatment 757810.0 -145000.0 -0.83 696800.0 -241000.0 -1.21 649210.0 -137955.9375 -0.759488813954343 576880.0 -202817.0 -1.21018590443079 -2.0033 -0.9791 1954120 Maybridge1_005682 CCCCn1c(=O)c(C(=O)C)c(O)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K07 compound treatment 794210.0 -109000.0 -0.62 746730.0 -191000.0 -0.96 655110.0 -132055.9375 -0.727007544329172 624700.0 -154997.0 -0.92484941907759 -1.6156 -0.9857 1954121 Maybridge1_005683 COc1ccc(cc1CS/C(=N/S(=O)(=O)c2ccccc2)/Nc3cccc(F)c3)C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K08 compound treatment 729770.0 -174000.0 -0.99 741350.0 -197000.0 -0.98 637690.0 -149475.9375 -0.822909869222471 644120.0 -135577.0 -0.808972494243646 -1.8031 -0.9955 1220324 Maybridge1_005684 CC12CCC3C(CCC4=CC(=O)CCC34CO)C2CCC1OC(=O)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K09 compound treatment 729140.0 -174000.0 -0.99 796600.0 -141000.0 -0.71 673200.0 -113965.9375 -0.627416668478439 632230.0 -147467.0 -0.879918767996252 -1.6045 -0.9843 1954122 Maybridge1_005685 COc1ccc(OC)c(c1)S(=O)(=O)Nc2cccc(Br)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K10 compound treatment 699840.0 -203000.0 -1.16 751880.0 -186000.0 -0.93 590170.0 -196995.9375 -1.0845217222035 597240.0 -182457.0 -1.0887001068191 -2.1329 -0.9969 1954123 Maybridge1_005686 CC12CCC3C(CC4OCC53CCC(O)C[C@]45Br)C2CCC1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K11 compound treatment 638250.0 -265000.0 -1.51 679470.0 -258000.0 -1.29 577160.0 -210005.9375 -1.15614567437697 590580.0 -189117.0 -1.12843956713805 -2.5456 -0.9929 1954124 Maybridge1_005687 CC(C)(C)C(=O)NCNc1cc(ccc1Cl)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K12 compound treatment 602440.0 -301000.0 -1.72 618720.0 -319000.0 -1.6 483700.0 -303465.9375 -1.67067100643941 511610.0 -268087.0 -1.5996445493284 -3.2927 -0.9995 1607696 Maybridge1_005688 CC(=O)OC1CCC2C3CCc4cc(OC(=O)C)ccc4C3=CCC12C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K13 compound treatment 684590.0 -219000.0 -1.25 853210.0 -84700.0 -0.42 561760.0 -225405.9375 -1.2409272933986 581920.0 -197777.0 -1.18011279932456 -2.047 -0.947 1954125 Maybridge1_005689 Fc1ccc(NC(=O)CSc2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K14 compound treatment 744810.0 -158000.0 -0.91 795250.0 -143000.0 -0.71 659110.0 -128055.9375 -0.704986344583294 645070.0 -134627.0 -0.803303952606559 -1.5636 -0.9947 1954126 Maybridge1_005690 [O-][N+](=O)c1ccc(cc1)C(=O)c2ccc(Br)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K15 compound treatment 779590.0 -124000.0 -0.71 805140.0 -133000.0 -0.66 641320.0 -145845.9375 -0.802925630453087 673460.0 -106237.0 -0.633904060946638 -1.4038 -0.9959 1954127 Maybridge1_005691 OC(=O)c1cccc2cccc(I)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K16 compound treatment 773440.0 -130000.0 -0.74 776060.0 -162000.0 -0.81 661220.0 -125945.9375 -0.693370161717344 664110.0 -115587.0 -0.68969444442745 -1.4672 -0.9978 1025088 Maybridge1_005692 O=C1CSc2nc3ccccc3n12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K17 compound treatment 726590.0 -177000.0 -1.01 720320.0 -218000.0 -1.09 623280.0 -163885.9375 -0.902241241306997 614130.0 -165567.0 -0.98791940339761 -1.9939 -0.9978 1303991 Maybridge1_005693 CCCN(CCC)S(=O)(=O)c1cccc2c(N)cccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K18 compound treatment 688200.0 -215000.0 -1.23 783170.0 -155000.0 -0.77 633770.0 -153395.9375 -0.844490644973432 631120.0 -148577.0 -0.886542011382744 -1.8668 -0.9829 1597977 Maybridge1_005694 COc1ccc2CCC(=O)c3cccc1c23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K19 compound treatment 769770.0 -134000.0 -0.76 774560.0 -163000.0 -0.82 646480.0 -140685.9375 -0.774518282780904 657830.0 -121867.0 -0.727166488091568 -1.5407 -0.9991 1954128 Maybridge1_005695 COCCCn1c(O)cc(C)c(C#N)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K20 compound treatment 846320.0 -57000.0 -0.33 891620.0 -46300.0 -0.23 700080.0 -87085.9375 -0.479434206186138 662820.0 -116877.0 -0.697391727282022 -0.8669 -0.9264 1930200 Maybridge1_005696 CC(=O)c1ccc(cc1)N2C(=O)c3ccccc3C2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K21 compound treatment 750340.0 -153000.0 -0.87 806400.0 -132000.0 -0.66 686720.0 -100445.9375 -0.552985013337371 660860.0 -118837.0 -0.709086823712224 -1.3968 -0.9865 1954129 Maybridge1_005697 OC(=O)c1ccccc1/C=C/c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K22 compound treatment 41300.0 -862000.0 -4.92 43760.0 -894000.0 -4.47 36670.0 -750495.9375 -4.13170523703938 28200.0 -751497.0 -4.4840968785754 -9.006 -0.9981 1954130 Maybridge1_005698 CN(C)c1ccc(/C=C(\C)/[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K23 mock treatment 802530.0 -101000.0 -0.58 902280.0 -35700.0 -0.18 708110.0 -79055.9375 -0.435226647696288 689440.0 -90257.0 -0.538553223724886 -0.8638 -0.9411 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 K24 mock treatment 1028000.0 125000.0 0.71 1017460.0 79500.0 0.4 827920.0 40754.0625 0.224363337692125 774940.0 -4757.0 -0.0283844763869759 0.6531 0.7713 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L01 compound treatment 970530.0 67300.0 0.38 787380.0 -151000.0 -0.75 690400.0 -96765.9375 -0.532725509571163 756980.0 -22717.0 -0.135549747757606 -0.5185 -0.5142 1954131 Maybridge1_005699 CC(C)c1ccc(NNC(=S)N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L02 compound treatment 810340.0 -92900.0 -0.53 830640.0 -107000.0 -0.54 690530.0 -96635.9375 -0.532009820579422 734260.0 -45437.0 -0.271117396173013 -0.9353 -0.9718 1740357 Maybridge1_005700 CCOC(=O)Cc1csc(NC(=O)COCC(=O)O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L03 compound treatment 788510.0 -115000.0 -0.66 690350.0 -248000.0 -1.24 705470.0 -81695.9375 -0.449760639528568 632980.0 -146717.0 -0.875443603545919 -1.6095 -0.94 1954132 Maybridge1_005701 COc1ccc(cc1)C(=O)CSc2nc(SCC(=O)c3ccc(OC)cc3)c4ccccc4n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L04 compound treatment 649380.0 -254000.0 -1.45 669470.0 -268000.0 -1.34 587420.0 -199745.9375 -1.09966129702879 586100.0 -193597.0 -1.15517121612137 -2.524 -0.9938 1954133 Maybridge1_005702 COc1ccc(cc1)/C(=C/c2ccco2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L05 compound treatment 689230.0 -214000.0 -1.22 663410.0 -275000.0 -1.37 618930.0 -168235.9375 -0.926189296030639 542800.0 -236897.0 -1.4135373770539 -2.4677 -0.9882 1954134 Maybridge1_005703 CCOC(=O)C1C(C(C(=O)OCC)C(O)(NC1(O)C(F)(F)F)C(F)(F)F)c2ccc(OC)c(OC)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L06 compound treatment 715450.0 -188000.0 -1.07 794180.0 -144000.0 -0.72 696200.0 -90965.9375 -0.50079476993964 666180.0 -113517.0 -0.677342990544532 -1.485 -0.9631 1055764 Maybridge1_005704 [O-][N+](=O)c1ccc(cc1)c2cc3ccccc3oc2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L07 compound treatment 823440.0 -79800.0 -0.46 744270.0 -194000.0 -0.97 661190.0 -125975.9375 -0.693535320715438 608870.0 -170827.0 -1.01930522340928 -1.5688 -0.9607 1466179 Maybridge1_005705 Ic1ccc(NC(=O)c2cnccn2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L08 compound treatment 685530.0 -218000.0 -1.24 637410.0 -301000.0 -1.5 588680.0 -198485.9375 -1.09272461910884 551630.0 -228067.0 -1.36084977425866 -2.6003 -0.9933 1954135 Maybridge1_005706 [O-][N+](=O)c1cc2C(=O)N(Cc3ccncc3)C(=O)c4cccc(c1)c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L09 compound treatment 806240.0 -97000.0 -0.55 762330.0 -176000.0 -0.88 701670.0 -85495.9375 -0.470680779287152 652980.0 -126717.0 -0.756105884870385 -1.3297 -0.9719 1565743 Maybridge1_005707 OCCn1ncc2ccccc2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L10 compound treatment 472600.0 -431000.0 -2.46 468320.0 -470000.0 -2.35 421080.0 -366085.9375 -2.01541288846113 409300.0 -370397.0 -2.2101166492131 -4.5173 -0.9973 1954136 Maybridge1_005708 CCOc1ccc(/C=C(\C#N)/c2cccc(Cl)c2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L11 compound treatment 867370.0 -35900.0 -0.21 769950.0 -168000.0 -0.84 687520.0 -99645.9375 -0.548580773388195 638330.0 -141367.0 -0.843520763800214 -1.2187 -0.9185 1257114 Maybridge1_005709 CSCC(O)Cn1ncc2ccccc2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L12 compound treatment 507150.0 -396000.0 -2.26 602080.0 -336000.0 -1.68 462910.0 -324255.9375 -1.78512619211861 506880.0 -272817.0 -1.62786791979516 -3.6778 -0.9908 1954137 Maybridge1_005710 N#C/C(=C\c1ccc2OCOc2c1)/c3nc4ccccc4[nH]3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L13 compound treatment 962880.0 59600.0 0.34 915410.0 -22500.0 -0.11 783730.0 -3435.9375 -0.0189158665004632 704870.0 -74827.0 -0.446484173766711 -0.1188 -0.2073 1660703 Maybridge1_005711 O=C1N(CN2CCN(Cc3csc4ccccc34)CC2)C(=O)c5ccccc15 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L14 compound treatment 760330.0 -143000.0 -0.82 803780.0 -134000.0 -0.67 644990.0 -142175.9375 -0.782721179686244 753490.0 -26207.0 -0.156374179666487 -1.2133 -0.9161 1589700 Maybridge1_005712 CC(=O)N(C(=O)C)c1ccc2CCc3cccc1c32 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L15 compound treatment 565620.0 -338000.0 -1.93 591760.0 -346000.0 -1.73 442610.0 -344555.9375 -1.89688378082894 490660.0 -289037.0 -1.72465080964102 -3.6409 -0.9987 1954138 Maybridge1_005713 CCOC(=O)CSC(=S)NCc1ccc(C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L16 compound treatment 758150.0 -145000.0 -0.83 814350.0 -124000.0 -0.62 617120.0 -170045.9375 -0.936153888915649 644910.0 -134787.0 -0.804258654355963 -1.5938 -0.9898 1954139 Maybridge1_005714 O=C1N(CCc2ccccn2)C(=O)c3cccc4cccc1c34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L17 compound treatment 730270.0 -173000.0 -0.99 700160.0 -238000.0 -1.19 590460.0 -196705.9375 -1.08292518522193 598530.0 -181167.0 -1.08100282396453 -2.1707 -0.9979 1954140 Maybridge1_005715 CC(=O)c1ccc(cc1)N2C(=O)CSCC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L18 compound treatment 696700.0 -207000.0 -1.18 878240.0 -59700.0 -0.3 594170.0 -192995.9375 -1.06250052245762 592760.0 -186937.0 -1.11543175580242 -1.8283 -0.9312 1954141 Maybridge1_005716 [O-][N+](=O)c1cc2C(=O)N(Cc3ccco3)C(=O)c4cccc(c1)c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L19 compound treatment 829220.0 -74100.0 -0.42 818680.0 -119000.0 -0.6 708380.0 -78785.9375 -0.433740216713441 640550.0 -139147.0 -0.830274277027229 -1.1417 -0.9608 1925350 Maybridge1_005717 COc1cc(/C=C/C(=O)NCc2ccc3OCOc3c2)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L20 compound treatment 716480.0 -187000.0 -1.07 924770.0 -13200.0 -0.07 619870.0 -167295.9375 -0.921014314090358 637510.0 -142187.0 -0.848413610265911 -1.4512 -0.8814 1954142 Maybridge1_005718 Oc1ccc(Br)cc1/C=N/c2ccc3OCOc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L21 compound treatment 759920.0 -143000.0 -0.82 764670.0 -173000.0 -0.87 665920.0 -121245.9375 -0.667495252015937 681970.0 -97727.0 -0.583125861650198 -1.4681 -0.9882 1235602 Maybridge1_005719 CC1CC(CC(C)(C)C1)N2CNc3c(C2)c(=O)n(C)c(=O)n3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L22 compound treatment 702460.0 -201000.0 -1.15 746300.0 -192000.0 -0.96 594140.0 -193025.9375 -1.06266568145572 576730.0 -202967.0 -1.21108093732086 -2.1897 -0.9963 1954143 Maybridge1_005720 Cc1cccnc1NC(=S)Nc2cccc(c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L23 mock treatment 769120.0 -134000.0 -0.77 887790.0 -50100.0 -0.25 708960.0 -78205.9375 -0.430547142750289 774260.0 -5437.0 -0.032441958821944 -0.7401 -0.8091 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 L24 mock treatment 806840.0 -96400.0 -0.55 902930.0 -35000.0 -0.18 809470.0 22304.0625 0.122790553864262 729080.0 -50617.0 -0.302025865309976 -0.4526 -0.682 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M01 compound treatment 525000.0 -378000.0 -2.16 560400.0 -378000.0 -1.89 495630.0 -291535.9375 -1.60499277819733 456640.0 -323057.0 -1.92764426910811 -3.7909 -0.9946 1351940 Maybridge1_005721 CC(C)c1ccc(cc1)C2CC(=O)Nc3ccccc3S2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M02 compound treatment 837290.0 -66000.0 -0.38 785400.0 -153000.0 -0.76 759570.0 -27595.9375 -0.151923912965567 655310.0 -124387.0 -0.742203040644685 -1.017 -0.8926 1619898 Maybridge1_005722 CCCCn1c(=O)c(CC)c(O)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M03 compound treatment 536660.0 -367000.0 -2.09 573440.0 -364000.0 -1.82 459370.0 -327795.9375 -1.80461495389372 497830.0 -281867.0 -1.68186823749584 -3.7019 -0.9967 1615702 Maybridge1_005723 COc1cccc(OCc2ccc(Cl)cc2)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M04 compound treatment 767200.0 -136000.0 -0.78 808370.0 -130000.0 -0.65 695520.0 -91645.9375 -0.504538373896439 610620.0 -169077.0 -1.00886317302517 -1.4694 -0.9696 1579375 Maybridge1_005724 Oc1cc(=O)n2CCCc3cccc1c32 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M05 compound treatment 700220.0 -203000.0 -1.16 754670.0 -183000.0 -0.92 584350.0 -202815.9375 -1.11656256783376 503520.0 -276177.0 -1.64791665653265 -2.4205 -0.9762 1126929 Maybridge1_005725 Nc1nc(N)c2c(Oc3ccc(F)cc3)cccc2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M06 compound treatment 751550.0 -152000.0 -0.87 846720.0 -91200.0 -0.46 663960.0 -123205.9375 -0.678285639891417 708970.0 -70727.0 -0.422019941438226 -1.2116 -0.9586 1954144 Maybridge1_005726 CCOC(=O)C1=C(C)N(C(=O)C)C(=NC1c2ccccc2)SC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M07 compound treatment 802930.0 -100000.0 -0.57 792110.0 -146000.0 -0.73 666330.0 -120835.9375 -0.665238079041984 636510.0 -143187.0 -0.854380496199687 -1.4111 -0.9897 1954145 Maybridge1_005727 OC(=O)CS/C(=N/S(=O)(=O)c1ccccc1)/Nc2cccc(c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M08 compound treatment 769340.0 -134000.0 -0.77 755800.0 -182000.0 -0.91 655010.0 -132155.9375 -0.727558074322819 633960.0 -145737.0 -0.869596055330818 -1.6366 -0.9959 1497952 Maybridge1_005728 CC(=O)OC1CCC2(C)C3C(CC4(C)C(CC=C4OC(=O)C)C3CC[C@@]2(C)C1)OC(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M09 compound treatment 833760.0 -69500.0 -0.4 865520.0 -72400.0 -0.36 727150.0 -60015.9375 -0.330405736905908 671050.0 -108647.0 -0.648284256047039 -0.869 -0.9606 1954146 Maybridge1_005729 Clc1ccc(cc1Cl)n2c(=O)[nH][nH]c2=S 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M10 compound treatment 785650.0 -118000.0 -0.67 958980.0 21000.0 0.11 726880.0 -60285.9375 -0.331892167888755 690100.0 -89597.0 -0.534615079008593 -0.7166 -0.7734 1954147 Maybridge1_005730 CC12CCC3C(CC[C@H]4CC5(CCC43C)OCCO5)C2CCC1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M11 compound treatment 677600.0 -226000.0 -1.29 964640.0 26700.0 0.13 612400.0 -174765.9375 -0.962138904615785 624000.0 -155697.0 -0.929026239231234 -1.5234 -0.818 1954148 Maybridge1_005731 CC(C)(C)C(=O)NC(=S)Nc1cccc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M12 compound treatment 840420.0 -62900.0 -0.36 732960.0 -205000.0 -1.03 725440.0 -61725.9375 -0.339819799797271 615900.0 -163797.0 -0.977358015294826 -1.3507 -0.9003 1954149 Maybridge1_005732 CC(=O)O[C@@]1(CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC21C)C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M13 compound treatment 439690.0 -464000.0 -2.65 634890.0 -303000.0 -1.52 208490.0 -578675.9375 -3.18578460195519 421390.0 -358307.0 -2.13797699827374 -4.7438 -0.9677 1954150 Maybridge1_005733 Clc1ccc(SCCC(=O)c2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M14 compound treatment 656050.0 -247000.0 -1.41 642720.0 -295000.0 -1.48 556520.0 -230645.9375 -1.2697750650657 512170.0 -267527.0 -1.59630309320548 -2.8774 -0.9967 1954151 Maybridge1_005734 CC12CCC3C(CCc4cc(Oc5ccc(cc5)[N+](=O)[O-])ccc34)C2CCC1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M15 compound treatment 798530.0 -105000.0 -0.6 802740.0 -135000.0 -0.68 684910.0 -102255.9375 -0.562949606222381 640250.0 -139447.0 -0.832064342807362 -1.3348 -0.9882 1954152 Maybridge1_005735 OC(=O)c1ccccc1CS(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M16 compound treatment 820080.0 -83200.0 -0.48 926520.0 -11400.0 -0.06 625250.0 -161915.9375 -0.891395800432152 635840.0 -143857.0 -0.858378309775318 -1.141 -0.86 1954153 Maybridge1_005736 S=C1NN=C(CS1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M17 compound treatment 648980.0 -254000.0 -1.45 823840.0 -114000.0 -0.57 519460.0 -267705.9375 -1.47380148071126 555310.0 -224387.0 -1.33889163402236 -2.418 -0.9558 1954154 Maybridge1_005737 Cn1c(n[nH]c1=S)c2ccccc2O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M18 compound treatment 719650.0 -184000.0 -1.05 767440.0 -170000.0 -0.85 655110.0 -132055.9375 -0.727007544329172 603040.0 -176657.0 -1.05409216840319 -1.8414 -0.9889 419 Maybridge1_005738 CC1=NN(C(=O)C1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M19 compound treatment 770240.0 -133000.0 -0.76 834510.0 -103000.0 -0.52 645460.0 -141705.9375 -0.780133688716103 685090.0 -94607.0 -0.564509177536814 -1.3109 -0.9847 1914168 Maybridge1_005739 CC1=NN(C(=O)C1N=Nc2ccc(cc2)[N+](=O)[O-])c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M20 compound treatment 710670.0 -193000.0 -1.1 716500.0 -221000.0 -1.11 604360.0 -182805.9375 -1.006401516105 579060.0 -200637.0 -1.19717809309516 -2.2057 -0.9981 1954155 Maybridge1_005740 CSc1c(c(N)nn1S(=O)(=O)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M21 compound treatment 806450.0 -96800.0 -0.55 785790.0 -152000.0 -0.76 634980.0 -152185.9375 -0.837829232050304 676320.0 -103377.0 -0.616838767176036 -1.3844 -0.987 1228318 Maybridge1_005741 Oc1c(Cc2ccccc2)c(=O)n(Cc3ccccc3)c4ccccc14 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M22 compound treatment 684190.0 -219000.0 -1.25 697010.0 -241000.0 -1.2 615600.0 -171565.9375 -0.944521944819083 573790.0 -205907.0 -1.22862358196616 -2.3148 -0.9943 1954156 Maybridge1_005742 OC(=O)c1ccccc1NC(=O)Nc2ccc(cc2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M23 mock treatment 826090.0 -77200.0 -0.44 892290.0 -45600.0 -0.23 730090.0 -57075.9375 -0.314220155092688 699840.0 -79857.0 -0.476497610013608 -0.73 -0.9649 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 M24 mock treatment 1005840.0 103000.0 0.59 826090.0 -112000.0 -0.56 802530.0 15364.0625 0.0845837723051637 738460.0 -41237.0 -0.246056475251151 -0.0675 -0.0793 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N01 compound treatment 812960.0 -90300.0 -0.52 822520.0 -115000.0 -0.58 661540.0 -125625.9375 -0.691608465737673 659450.0 -120247.0 -0.717500132878849 -1.2511 -0.9914 1198258 Maybridge1_005743 NCc1csc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N02 compound treatment 831750.0 -71500.0 -0.41 743310.0 -195000.0 -0.97 673130.0 -114035.9375 -0.627802039473992 650820.0 -128877.0 -0.768994358487343 -1.3894 -0.9588 1328597 Maybridge1_005744 Cn1c(NC2CCN(Cc3ccccc3)CC2)cc(=O)n(C)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N03 compound treatment 672890.0 -230000.0 -1.32 567300.0 -371000.0 -1.85 519040.0 -268125.9375 -1.47611370668458 546330.0 -233367.0 -1.39247426970767 -3.0192 -0.9908 1954157 Maybridge1_005745 FC(F)(F)Oc1ccc(NC(=O)c2cnccn2)c(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N04 compound treatment 792060.0 -111000.0 -0.64 916860.0 -21100.0 -0.11 715390.0 -71775.9375 -0.39514806415879 662880.0 -116817.0 -0.697033714125995 -0.9164 -0.8915 1668560 Maybridge1_005746 CN(C)c1ccc(C=C(c2ccc(N)cc2)c3ccc(N)cc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N05 compound treatment 762350.0 -141000.0 -0.81 738490.0 -199000.0 -1.0 662990.0 -124175.9375 -0.683625780829793 600060.0 -179637.0 -1.07187348848585 -1.779 -0.9854 1954158 Maybridge1_005747 CCOC(=O)C1C(C(C(=O)OCC)C(O)(NC1(O)C(F)(F)F)C(F)(F)F)c2ccc(C#N)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N06 compound treatment 779650.0 -124000.0 -0.71 784650.0 -153000.0 -0.77 683260.0 -103905.9375 -0.572033351117555 646940.0 -132757.0 -0.792145875910396 -1.4185 -0.9929 1954159 Maybridge1_005748 [O-][N+](=O)c1ccc(cc1)c2cc3cc(Br)ccc3oc2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N07 compound treatment 784980.0 -118000.0 -0.68 889380.0 -48600.0 -0.24 695680.0 -91485.9375 -0.503657525906604 652800.0 -126897.0 -0.757179924338465 -1.0897 -0.9405 1363436 Maybridge1_005749 COc1cc(NC(=O)c2cnccn2)cc(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N08 compound treatment 780430.0 -123000.0 -0.7 834730.0 -103000.0 -0.52 635100.0 -152065.9375 -0.837168596057927 642260.0 -137437.0 -0.820070902080471 -1.4376 -0.9845 1516801 Maybridge1_005750 COc1ccc(NC(C(=O)O)c2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N09 compound treatment 650170.0 -253000.0 -1.45 635460.0 -302000.0 -1.51 574210.0 -212955.9375 -1.17238630918956 525790.0 -253907.0 -1.51503410678745 -2.8231 -0.9951 1538120 Maybridge1_005751 CC(C)c1ccc(cc1)n2ncc3ccccc3c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N10 compound treatment 775590.0 -128000.0 -0.73 826300.0 -112000.0 -0.56 691300.0 -95865.9375 -0.527770739628341 660810.0 -118887.0 -0.709385168008913 -1.2624 -0.9902 1954160 Maybridge1_005752 COc1ccc(/C=C\2/N=C(OC2=O)c3ccc(cc3)[N+](=O)[O-])cc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N11 compound treatment 830400.0 -72900.0 -0.42 817130.0 -121000.0 -0.6 694400.0 -92765.9375 -0.510704309825285 633450.0 -146247.0 -0.872639167157044 -1.2019 -0.9621 1954161 Maybridge1_005753 OC(=O)CC(CC(=O)NCCc1c[nH]c2ccccc12)c3ccc(cc3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N12 compound treatment 611250.0 -292000.0 -1.67 616850.0 -321000.0 -1.61 516120.0 -271045.9375 -1.49218918249907 461380.0 -318317.0 -1.899361229782 -3.3328 -0.996 1934652 Maybridge1_005754 COc1ccc(/C=C(\C#N)/c2nc3ccccc3[nH]2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N13 compound treatment 774160.0 -129000.0 -0.74 633030.0 -305000.0 -1.52 560390.0 -226775.9375 -1.24846955431156 551130.0 -228567.0 -1.36383321722554 -2.4374 -0.972 1954162 Maybridge1_005755 COc1cc(/C=C/2\CCc3ccccc3C2=O)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N14 compound treatment 813210.0 -90100.0 -0.51 977190.0 39300.0 0.2 681760.0 -105405.9375 -0.58029130102226 647220.0 -132477.0 -0.790475147848939 -0.8444 -0.7509 1954163 Maybridge1_005756 O=C1N(CCCN2CCOCC2)C(=O)c3cccc4cccc1c34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N15 compound treatment 812610.0 -90700.0 -0.52 947620.0 9690.0 0.05 696910.0 -90255.9375 -0.496886006984747 666030.0 -113667.0 -0.678238023434599 -0.8223 -0.8317 1156124 Maybridge1_005757 OCCN1CCN(Cn2nnc3ccccc23)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N16 compound treatment 813010.0 -90300.0 -0.52 864060.0 -73900.0 -0.37 699300.0 -87865.9375 -0.483728340136584 636100.0 -143597.0 -0.856826919432536 -1.1128 -0.9506 1954164 Maybridge1_005758 O=C1N(Cc2ccccn2)C(=O)c3cccc4cccc1c34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N17 compound treatment 789360.0 -114000.0 -0.65 859360.0 -78600.0 -0.39 703440.0 -83725.9375 -0.460936398399601 664500.0 -115197.0 -0.687367358913277 -1.096 -0.9753 1725522 Maybridge1_005759 COc1ccc(cc1)C2C(C(=O)O)c3ccccc3C(=O)N2CC4CC4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N18 compound treatment 765870.0 -137000.0 -0.78 854760.0 -83200.0 -0.42 614840.0 -172325.9375 -0.9487059727708 630240.0 -149457.0 -0.891792871004467 -1.5207 -0.9648 1954165 Maybridge1_005760 [O-][N+](=O)c1cc2C(=O)N(Cc3ccccc3)C(=O)c4cccc(c1)c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N19 compound treatment 772640.0 -131000.0 -0.75 791870.0 -146000.0 -0.73 672320.0 -114845.9375 -0.632261332422532 685550.0 -94147.0 -0.561764410007277 -1.3354 -0.9937 1544026 Maybridge1_005761 OC(=O)C1C(N(Cc2ccc3OCOc3c2)C(=O)c4ccccc14)c5cccnc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N20 compound treatment 657220.0 -246000.0 -1.41 581600.0 -356000.0 -1.78 485600.0 -301565.9375 -1.66021093656012 396130.0 -383567.0 -2.28870053696094 -3.5684 -0.9842 1954166 Maybridge1_005762 Cc1ccc(NC(=S)Nc2ccc(Cl)c(Cl)c2)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N21 compound treatment 826900.0 -76400.0 -0.44 755400.0 -183000.0 -0.91 676280.0 -110885.9375 -0.610460344674113 682900.0 -96797.0 -0.577576657731785 -1.2686 -0.9645 1702594 Maybridge1_005763 COc1ccc(CCN2CNc3c(C2)c(=O)n(C)c(=O)n3C)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N22 compound treatment 821920.0 -81400.0 -0.46 1030080.0 92100.0 0.46 668410.0 -118755.9375 -0.653787055174128 654950.0 -124747.0 -0.744351119580845 -0.701 -0.5904 1136435 Maybridge1_005764 CCOC(=O)c1ccc(NC(=S)Nc2ncccc2C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N23 mock treatment 895220.0 -8050.0 -0.05 906880.0 -31100.0 -0.16 810260.0 23094.0625 0.127139740814073 767040.0 -12657.0 -0.075522875263812 -0.0748 -0.3413 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 N24 mock treatment 927810.0 24500.0 0.14 987280.0 49300.0 0.25 741920.0 -45245.9375 -0.249092456844254 777230.0 -2467.0 -0.0147203075986272 0.0616 0.163 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O01 compound treatment 761810.0 -141000.0 -0.81 729240.0 -209000.0 -1.04 798620.0 11454.0625 0.0630580495535679 564000.0 -215697.0 -1.28703939525784 -1.5379 -0.8337 1954167 Maybridge1_005765 Cc1c(/C=N/NC(=S)N)sc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O02 compound treatment 1019320.0 116000.0 0.66 954910.0 17000.0 0.08 985120.0 197954.0625 1.08979648770513 734730.0 -44967.0 -0.268312959784138 0.7847 0.6007 1570365 Maybridge1_005766 CCCCn1c(=O)c(Cc2ccccc2)c(O)c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O03 compound treatment 785990.0 -117000.0 -0.67 690140.0 -248000.0 -1.24 792560.0 5394.0625 0.0296959319385626 646470.0 -133227.0 -0.794950312299271 -1.3373 -0.8265 1685933 Maybridge1_005767 COc1cccc(OCc2ccccc2Cl)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O04 compound treatment 882810.0 -20500.0 -0.12 841790.0 -96100.0 -0.48 906090.0 118924.0625 0.654712633725947 703310.0 -76387.0 -0.455792515823402 -0.1994 -0.2124 1347568 Maybridge1_005768 COc1ccc2c(O)c(c3ccccc3)c(=O)[nH]c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O05 compound treatment 668050.0 -235000.0 -1.34 619560.0 -318000.0 -1.59 576420.0 -210745.9375 -1.16021959632996 592280.0 -187417.0 -1.11829586105063 -2.6073 -0.9899 1503605 Maybridge1_005769 Cc1ccc(COc2cccc(F)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O06 compound treatment 790110.0 -113000.0 -0.65 751490.0 -186000.0 -0.93 668800.0 -118365.9375 -0.651639988198905 610400.0 -169297.0 -1.0101758879306 -1.6204 -0.9802 1140779 Maybridge1_005770 CC1(C)c2ccccc2-n3c1cc(O)c(c4ccccc4)c3=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O07 compound treatment 925120.0 21800.0 0.12 1039150.0 101000.0 0.51 797290.0 10124.0625 0.0557360006380634 685520.0 -94177.0 -0.56194341658529 0.0624 0.0812 1954168 Maybridge1_005771 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)c2ccccc2C(=O)N3CCOCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O08 compound treatment 782460.0 -121000.0 -0.69 861010.0 -76900.0 -0.38 658030.0 -129135.9375 -0.710932068514681 653790.0 -125907.0 -0.751272707264026 -1.2685 -0.9746 1227353 Maybridge1_005772 CC12CCC3C(CC[C@@]4(C)CC(=O)CCC34CO)C2CCC1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O09 compound treatment 891400.0 -11900.0 -0.07 875010.0 -62900.0 -0.31 700670.0 -86495.9375 -0.476186079223621 720110.0 -59587.0 -0.355548832135954 -0.6071 -0.8983 1954169 Maybridge1_005773 COC(=O)c1ccc(COCOCc2ccc(o2)C(=O)OC)o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O10 compound treatment 644060.0 -259000.0 -1.48 520580.0 -417000.0 -2.09 592350.0 -194815.9375 -1.072520168342 457700.0 -321997.0 -1.9213193700183 -3.281 -0.9721 1044579 Maybridge1_005774 CC12CCC3C(CCC4=CCCCC34)C2CCC1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O11 compound treatment 872680.0 -30600.0 -0.17 1064600.0 127000.0 0.63 702400.0 -84765.9375 -0.466661910333529 687050.0 -92647.0 -0.552814081106612 -0.2804 -0.2868 1702653 Maybridge1_005775 Fc1ccc(cc1Cl)c2n[nH]c(=O)c3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O12 compound treatment 800000.0 -103000.0 -0.59 981300.0 43400.0 0.22 767420.0 -19745.9375 -0.108707308464281 708760.0 -70937.0 -0.423272987484319 -0.4525 -0.5911 1011810 Maybridge1_005776 CC12CCC3C(CCC4=CC(=O)CCC34)C2CCC1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O13 compound treatment 793440.0 -110000.0 -0.63 812820.0 -125000.0 -0.63 710040.0 -77125.9375 -0.424601418818902 667470.0 -112227.0 -0.66964570768996 -1.1737 -0.9871 1954170 Maybridge1_005777 Fc1ccc(N2C(=O)CCC2=O)c(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O14 compound treatment 860050.0 -43200.0 -0.25 997250.0 59300.0 0.3 740170.0 -46995.9375 -0.258726731733075 701820.0 -77877.0 -0.46468317586473 -0.3368 -0.5125 1730077 Maybridge1_005778 CCOC(=O)Cc1cc(C)[nH]c1C(=O)OCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O15 compound treatment 753640.0 -150000.0 -0.85 858300.0 -79600.0 -0.4 675470.0 -111695.9375 -0.614919637622653 718100.0 -61597.0 -0.367542272862845 -1.1178 -0.9438 1116695 Maybridge1_005779 CCCCCCC(C)OC(=O)c1ccccc1C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O16 compound treatment 930960.0 27700.0 0.16 901960.0 -36000.0 -0.18 808560.0 21394.0625 0.117780730922075 729310.0 -50387.0 -0.300653481545208 -0.1023 -0.2545 1954171 Maybridge1_005780 OC(=O)[C@@H]1CSC(N1)c2cccc(O)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O17 compound treatment 798430.0 -105000.0 -0.6 824480.0 -113000.0 -0.57 693840.0 -93325.9375 -0.513787277789708 707390.0 -72307.0 -0.431447621213593 -1.0558 -0.9929 1641535 Maybridge1_005781 CC(=O)Nc1ccc2C(=O)CCCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O18 compound treatment 844730.0 -58500.0 -0.33 810620.0 -127000.0 -0.64 751850.0 -35315.9375 -0.194424828475111 671630.0 -108067.0 -0.644823462205449 -0.9052 -0.9187 1083145 Maybridge1_005782 CC1C(OCCN1CN2C(=O)c3ccccc3C2=O)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O19 compound treatment 785540.0 -118000.0 -0.67 783810.0 -154000.0 -0.77 647520.0 -139645.9375 -0.768792770846976 687140.0 -92557.0 -0.552277061372572 -1.3822 -0.9917 1954172 Maybridge1_005783 CCC(C(=O)N)(c1ccccc1)c2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O20 compound treatment 744960.0 -158000.0 -0.9 719790.0 -218000.0 -1.09 631440.0 -155725.9375 -0.857317993825406 612660.0 -167037.0 -0.996690725720262 -1.9247 -0.9957 1954173 Maybridge1_005784 COc1ccc(/C=C(\C#N)/c2cccs2)c(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O21 compound treatment 805880.0 -97400.0 -0.56 833440.0 -104000.0 -0.52 711010.0 -76155.9375 -0.419261277880526 727360.0 -52337.0 -0.312288909116072 -0.9053 -0.9785 1717986 Maybridge1_005785 Cc1ccc2c(O)c(c3ccccc3)c(=O)[nH]c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O22 compound treatment 862240.0 -41000.0 -0.23 872880.0 -65100.0 -0.33 700800.0 -86365.9375 -0.47547039023188 700450.0 -79247.0 -0.472857809594004 -0.754 -0.9651 1954174 Maybridge1_005786 FC(F)(F)c1ccc(Nc2nc3ccccc3c(=O)o2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O23 mock treatment 1084050.0 181000.0 1.03 1122080.0 184000.0 0.92 779160.0 -8005.9375 -0.0440750872101289 925380.0 145683.0 0.869273843490394 1.3895 0.85 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 O24 mock treatment 793920.0 -109000.0 -0.62 1007530.0 69600.0 0.35 780180.0 -6985.9375 -0.03845968127493 1011450.0 231753.0 1.38284371581056 0.5339 0.3428 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P01 compound treatment 911840.0 8570.0 0.05 907540.0 -30400.0 -0.15 863310.0 76144.0625 0.419195902443781 835930.0 56233.0 0.335535896714066 0.3258 0.5816 1954175 Maybridge1_005787 Clc1ccc(/C=C\2/N=C(OC2=O)c3ccccc3I)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P02 compound treatment 903460.0 187.0 0.0 805020.0 -133000.0 -0.66 674980.0 -112185.9375 -0.617617234591523 738920.0 -40777.0 -0.243311707721613 -0.7623 -0.8114 1383634 Maybridge1_005788 COc1ccc(cc1)C(=O)COc2cc(=O)oc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P03 compound treatment 938240.0 35000.0 0.2 927300.0 -10600.0 -0.05 929440.0 142274.0625 0.78326138724251 809760.0 30063.0 0.17938249182713 0.5546 0.6684 1683070 Maybridge1_005789 O=C1N(C(c2ccccc2)c3ccccc3)C(=O)c4nccnc14 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P04 compound treatment 837460.0 -65800.0 -0.38 899590.0 -38300.0 -0.19 741850.0 -45315.9375 -0.249477827839807 646950.0 -132747.0 -0.792086207051058 -0.8046 -0.8638 1954176 Maybridge1_005790 COc1ccc(cc1)/C(=C/c2ccc(NC(=O)C)cc2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P05 compound treatment 1121540.0 218000.0 1.25 805200.0 -133000.0 -0.66 943580.0 156414.0625 0.861106328344189 758560.0 -21137.0 -0.126122067982239 0.659 0.3972 1954177 Maybridge1_005791 COc1cc(NC(=O)CC(CC(=O)O)c2ccc(cc2)C(F)(F)F)cc(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P06 compound treatment 700350.0 -203000.0 -1.16 750590.0 -187000.0 -0.94 656000.0 -131165.9375 -0.722107827385715 583600.0 -196097.0 -1.17008843095581 -1.9942 -0.9834 1583290 Maybridge1_005792 CC(=O)ON1C(=O)c2cccc3cccc(C1=O)c23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P07 compound treatment 939650.0 36400.0 0.21 840500.0 -97400.0 -0.49 742880.0 -44285.9375 -0.243807368905243 697180.0 -82517.0 -0.492369526597454 -0.5078 -0.6654 1131102 Maybridge1_005793 Cn1c2NCN(CCCn3ccnc3)Cc2c(=O)n(C)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P08 compound treatment 863540.0 -39700.0 -0.23 909860.0 -28100.0 -0.14 842350.0 55184.0625 0.30380481577538 682440.0 -97257.0 -0.580321425261323 -0.3219 -0.4552 1419526 Maybridge1_005794 OC(=O)C(Nc1ccc2OCOc2c1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P09 compound treatment 917520.0 14200.0 0.08 901630.0 -36300.0 -0.18 741230.0 -45935.9375 -0.252891113800418 749920.0 -29777.0 -0.177675962450069 -0.2654 -0.722 1954178 Maybridge1_005795 CN(C)C(=O)Nc1cccc(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P10 compound treatment 842880.0 -60400.0 -0.34 819740.0 -118000.0 -0.59 771730.0 -15435.9375 -0.0849794657380974 771200.0 -8497.0 -0.0507006297793008 -0.5359 -0.7749 1063962 Maybridge1_005796 Cc1ccc(cc1)C(=O)NCC(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P11 compound treatment 916160.0 12900.0 0.07 976550.0 38600.0 0.19 786240.0 -925.9375 -0.00509756365992474 663520.0 -116177.0 -0.693214907128378 -0.2158 -0.2983 1954179 Maybridge1_005797 Fc1cccc(Cl)c1CSc2ccc(cn2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P12 compound treatment 1054340.0 151000.0 0.86 990100.0 52200.0 0.26 797190.0 10024.0625 0.0551854706444165 714480.0 -65217.0 -0.389142399943116 0.395 0.4016 1954180 Maybridge1_005798 Oc1ccc(Br)cc1/C=C(\C#N)/c2nc3ccccc3[nH]2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P13 compound treatment 792690.0 -111000.0 -0.63 847230.0 -90700.0 -0.45 657720.0 -129445.9375 -0.712638711494987 705800.0 -73897.0 -0.440934969848298 -1.1195 -0.9792 1954181 Maybridge1_005799 CCOC(=O)c1ccccc1CSC(=N)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P14 compound treatment 943290.0 40000.0 0.23 875700.0 -62200.0 -0.31 822520.0 35354.0625 0.194634718035189 728800.0 -50897.0 -0.303696593371434 -0.0959 -0.1814 1954182 Maybridge1_005800 Nc1ccc(cc1)C(=O)/C(=C\c2cccc(c2)[N+](=O)[O-])/C(=O)c3ccc(cc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P15 compound treatment 24350.0 -879000.0 -5.02 29930.0 -908000.0 -4.54 28000.0 -759165.9375 -4.17943618748857 23770.0 -755927.0 -4.51053018326204 -9.1261 -0.9978 1342828 Maybridge1_005801 Cn1c(=O)sn(c2cccc3ccccc23)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P16 compound treatment 790810.0 -112000.0 -0.64 1054920.0 117000.0 0.59 796290.0 9124.0625 0.0502307007015939 723140.0 -56557.0 -0.33746916775661 -0.1723 -0.1845 1400120 Maybridge1_005802 CCOC(=O)NN1C(=O)c2cccc3cccc(C1=O)c23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P17 compound treatment 1088010.0 185000.0 1.06 1032320.0 94400.0 0.47 715730.0 -71435.9375 -0.39327626218039 766970.0 -12727.0 -0.0759405572791763 0.5291 0.4324 1954183 Maybridge1_005803 [O-][N+](=O)c1ccc(C=C2C(=O)c3ccccc3C2=O)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P18 compound treatment 1041810.0 139000.0 0.79 836420.0 -102000.0 -0.51 851680.0 64514.0625 0.35516926418264 754130.0 -25567.0 -0.152555372668869 0.2431 0.2392 1954184 Maybridge1_005804 Brc1ccc2C(=O)N(CCc3ccccn3)C(=O)c4cccc1c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P19 compound treatment 1012720.0 109000.0 0.63 1097120.0 159000.0 0.8 897280.0 110114.0625 0.60621094128565 712640.0 -67057.0 -0.400121470061266 0.8137 0.6531 1474642 Maybridge1_005805 OC(=O)C1C(N(Cc2ccc(F)cc2)C(=O)c3ccccc13)c4cccnc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P20 compound treatment 1097780.0 195000.0 1.11 918420.0 -19500.0 -0.1 933540.0 146374.0625 0.805833116982035 731700.0 -47997.0 -0.286392624163481 0.7665 0.5453 1083096 Maybridge1_005806 Clc1ccc(NC2=NCCS2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P21 compound treatment 1028900.0 126000.0 0.72 1064400.0 126000.0 0.63 941560.0 154394.0625 0.849985622472521 877150.0 97453.0 0.581490934904343 1.3908 0.9895 1954185 Maybridge1_005807 Cn1c2NCN(CCCCCCO)Cc2c(=O)n(C)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P22 compound treatment 946020.0 42700.0 0.24 889620.0 -48300.0 -0.24 822010.0 34844.0625 0.19182701506759 681460.0 -98237.0 -0.586168973476424 -0.1959 -0.2775 1954186 Maybridge1_005808 Oc1csc(=N/N=C/c2ccccc2)n1c3cccc(c3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P23 mock treatment 1106950.0 204000.0 1.16 1061540.0 124000.0 0.62 960810.0 173644.0625 0.955962646249559 980800.0 201103.0 1.1999586619403 1.9688 0.9736 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.1233 P24 mock treatment 1048450.0 145000.0 0.83 1018770.0 80800.0 0.4 930500.0 143334.0625 0.789097005175168 907530.0 127833.0 0.76276492957248 1.3927 0.9714 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A01 compound treatment 853970.0 4940.0 0.03 846270.0 -115000.0 -0.58 835140.0 -23098.125 -0.127162106095065 876730.0 -84592.5 -0.504753798353007 -0.5906 -0.7591 1151876 Maybridge1_004753 CCOC(=O)c1sc(SCC)c2C(=O)CC(C)(C)Cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A02 compound treatment 888770.0 39700.0 0.23 937980.0 -23800.0 -0.12 913930.0 55691.875 0.306600475899368 1056720.0 95397.5 0.569226000867465 0.492 0.7074 3177140 Maybridge1_004754 Cc1cc(C)c(c(C)c1)S(=O)(=O)O.Clc1ccc(cc1)S(=N)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A03 compound treatment 895720.0 46700.0 0.27 921320.0 -40400.0 -0.2 1003400.0 145161.875 0.799159661215296 1017970.0 56647.5 0.338009170933617 0.6008 0.646 2071907 Maybridge1_004755 CCSc1sc(C#N)c2CC(C)(C)CC(=O)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A04 compound treatment 789650.0 -59400.0 -0.34 896740.0 -65000.0 -0.33 892640.0 34401.875 0.189392640251932 967010.0 5687.5 0.0339366637483551 -0.2205 -0.4343 3177141 Maybridge1_004756 CS(=N)c1ccsc1.Cc1cc(C)c(c(C)c1)S(=O)(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A05 compound treatment 773450.0 -75600.0 -0.43 790030.0 -172000.0 -0.86 729160.0 -129078.125 -0.710613793362104 866080.0 -95242.5 -0.568301133547729 -1.2848 -0.9706 1678777 Maybridge1_004757 NS(=O)(=O)c1ccc(Sc2ccc(Cl)cc2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A06 compound treatment 858560.0 9530.0 0.05 849370.0 -112000.0 -0.56 837600.0 -20638.125 -0.11361906825135 1060550.0 99227.5 0.59207917399383 -0.0146 -0.0177 1150718 Maybridge1_004758 NNC(=O)C1SCCN1S(=O)(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A07 compound treatment 909680.0 60700.0 0.35 869180.0 -92600.0 -0.46 1027480.0 169241.875 0.931727283685482 1124410.0 163087.5 0.973124509724811 0.8942 0.6099 2071909 Maybridge1_004759 COc1ccc(cc1)c2ccnc(S)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A08 compound treatment 904880.0 55900.0 0.32 924900.0 -36900.0 -0.18 909240.0 51001.875 0.280780619197326 983100.0 21777.5 0.129943858422823 0.2727 0.5668 2071910 Maybridge1_004760 OC(=O)c1ccc(CSc2ccc(cn2)C(F)(F)F)o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A09 compound treatment 861780.0 12800.0 0.07 951060.0 -10700.0 -0.05 874680.0 16441.875 0.0905174533929397 961280.0 -42.5 -2.53592652185511E-4 0.0548 0.4285 2071911 Maybridge1_004761 O=C(NCc1cccs1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A10 compound treatment 836970.0 -12100.0 -0.07 821520.0 -140000.0 -0.7 862400.0 4161.875 0.0229123701730941 890370.0 -70952.5 -0.423365474216293 -0.5854 -0.7117 2071912 Maybridge1_004762 CSc1ccc(OC(=O)Nc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A11 compound treatment 940130.0 91100.0 0.52 882560.0 -79200.0 -0.4 977350.0 119111.875 0.655746597870265 976490.0 15167.5 0.0905027424005584 0.4353 0.4678 2071913 Maybridge1_004763 CSc1nnc(c2cccs2)n1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A12 compound treatment 873680.0 24700.0 0.14 922190.0 -39600.0 -0.2 884700.0 26461.875 0.145680558756364 1036130.0 74807.5 0.446367819491002 0.2675 0.506 1448822 Maybridge1_004764 NNC(=O)CNS(=O)(=O)c1cccc2nsnc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A13 compound treatment 787360.0 -61700.0 -0.35 771740.0 -190000.0 -0.95 839200.0 -19038.125 -0.104810588352999 903680.0 -57642.5 -0.343946222437725 -0.8757 -0.8143 2071914 Maybridge1_004765 CNc1ccc(CSc2ccc(cn2)C(F)(F)F)cc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A14 compound treatment 896900.0 47900.0 0.27 925290.0 -36500.0 -0.18 969380.0 111141.875 0.611869357376603 1009500.0 48177.5 0.287469647074528 0.4952 0.6588 1026900 Maybridge1_004766 N=C(Nc1ccccc1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A15 compound treatment 838880.0 -10100.0 -0.06 899800.0 -62000.0 -0.31 858350.0 111.875 6.15905430392527E-4 900520.0 -60802.5 -0.362801581988459 -0.365 -0.7594 2071915 Maybridge1_004767 CCOC(=O)c1ncn(Cc2ccc(Cl)cc2)c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A16 compound treatment 945180.0 96200.0 0.55 963400.0 1650.0 0.01 1010100.0 151861.875 0.836045170789642 1014490.0 53167.5 0.317244407884074 0.8554 0.8151 2071916 Maybridge1_004768 Clc1ccc2nonc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A17 compound treatment 922000.0 73000.0 0.42 952900.0 -8850.0 -0.04 1035740.0 177501.875 0.97720106116072 1112860.0 151537.5 0.90420697718969 1.127 0.8074 2071917 Maybridge1_004769 Cc1nc(ncc1S(=O)(=O)c2ccc(Cl)cc2)c3cnccn3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A18 compound treatment 109600.0 -739000.0 -4.22 53450.0 -908000.0 -4.54 94880.0 -763358.125 -4.20251543706599 105240.0 -856082.5 -5.10814662740241 -9.0388 -0.9967 1087586 Maybridge1_004770 Cc1ccc(Sc2ccc([N+](=O)[O-])c3nonc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A19 compound treatment 828800.0 -20200.0 -0.12 945670.0 -16100.0 -0.08 948370.0 90131.875 0.496203005711378 1020800.0 59477.5 0.354895458126205 0.3276 0.5232 2071918 Maybridge1_004771 FC(F)(F)c1ccc(nc1)S(=O)(=O)/C(=C/Nc2ccc3OCCOc3c2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A20 compound treatment 891310.0 42300.0 0.24 933250.0 -28500.0 -0.14 937120.0 78881.875 0.434268381426096 1065280.0 103957.5 0.620302544460594 0.5768 0.7143 1774528 Maybridge1_004772 OC(=O)Cc1n[nH]c(=O)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A21 compound treatment 878410.0 29400.0 0.17 988990.0 27200.0 0.14 864570.0 6331.875 0.0348588710352329 1012690.0 51367.5 0.306504013203276 0.3227 0.8567 2071919 Maybridge1_004773 COC(=O)c1cccc(CSc2nnc(n2C)C(F)(F)F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A22 compound treatment 898770.0 49700.0 0.28 976970.0 15200.0 0.08 832840.0 -25398.125 -0.139824295948945 1025060.0 63737.5 0.380314392204094 0.3004 0.5999 1507929 Maybridge1_004774 COC(=O)c1sccc1NS(=O)(=O)c2cccc3nsnc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A23 mock treatment 921120.0 72100.0 0.41 922640.0 -39100.0 -0.2 980370.0 122131.875 0.672372603678403 1049760.0 88437.5 0.527696474768379 0.7081 0.731 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 A24 mock treatment 864520.0 15500.0 0.09 921130.0 -40600.0 -0.2 957210.0 98971.875 0.544869857149769 1085120.0 123797.5 0.738685561386724 0.5844 0.6189 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B01 compound treatment 899680.0 50700.0 0.29 946840.0 -14900.0 -0.07 927270.0 69031.875 0.380041177051872 1074080.0 112757.5 0.672811140677829 0.6338 0.765 1573898 Maybridge1_004775 CC1=Cn2n(C1)c(=O)c3ccccc3c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B02 compound treatment 758820.0 -90200.0 -0.52 858130.0 -104000.0 -0.52 837760.0 -20478.125 -0.112738220261515 870530.0 -90792.5 -0.541748491142423 -0.844 -0.9207 2071920 Maybridge1_004776 CC1=CS(=O)(=O)c2ccc(Cl)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B03 compound treatment 708130.0 -141000.0 -0.8 816020.0 -146000.0 -0.73 725730.0 -132508.125 -0.729496972144195 805120.0 -156202.5 -0.932042500070758 -1.5977 -0.9947 2071921 Maybridge1_004777 NNC(=O)CSc1cc(nc2ccccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B04 compound treatment 714430.0 -135000.0 -0.77 763150.0 -199000.0 -0.99 733760.0 -124478.125 -0.685289413654344 801960.0 -159362.5 -0.950897859621493 -1.6992 -0.989 2071922 Maybridge1_004778 [O-][N+](=O)c1ccc(cc1)N2CCC(CC2)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B05 compound treatment 692500.0 -157000.0 -0.89 869300.0 -92500.0 -0.46 812690.0 -45548.125 -0.250756089668806 894940.0 -66382.5 -0.396096805498933 -1.0017 -0.9021 1644315 Maybridge1_004779 Clc1ccccc1n2cc(C#N)c(=O)[nH]c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B06 compound treatment 695520.0 -154000.0 -0.88 923760.0 -38000.0 -0.19 763520.0 -94718.125 -0.521451687545012 949170.0 -12152.5 -0.0725125813102216 -0.8304 -0.7983 2071923 Maybridge1_004780 CCOC(=O)NC(=O)/C(=C/Nc1sc(C)c(C)c1C(=O)OCC)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B07 compound treatment 677640.0 -171000.0 -0.98 821600.0 -140000.0 -0.7 780990.0 -77248.125 -0.425274097654889 908130.0 -53192.5 -0.317393580032418 -1.2114 -0.9206 1717562 Maybridge1_004781 CC(C)n1cc(C(=S)N)c(=O)n(Cc2ccccc2)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B08 compound treatment 745940.0 -103000.0 -0.59 829140.0 -133000.0 -0.66 817930.0 -40308.125 -0.221908318001705 923200.0 -38122.5 -0.227472609010403 -0.8508 -0.903 2071924 Maybridge1_004782 CC(=O)Nc1cc(n[nH]1)c2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B09 compound treatment 831310.0 -17700.0 -0.1 859310.0 -102000.0 -0.51 837710.0 -20528.125 -0.113013485258338 933170.0 -28152.5 -0.167982756250649 -0.4473 -0.7985 2071925 Maybridge1_004783 O=C1N(CCCCN2CCN(CC2)C(c3ccccc3)c4ccccc4)C(=O)c5ccccc15 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B10 compound treatment 702600.0 -146000.0 -0.84 755310.0 -206000.0 -1.03 739920.0 -118318.125 -0.651376766045692 828700.0 -132622.5 -0.791343329752303 -1.6559 -0.9867 2071926 Maybridge1_004784 CN1CCN(CC1)/C=C(\C#N)/S(=O)(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B11 compound treatment 727280.0 -122000.0 -0.7 828860.0 -133000.0 -0.66 799360.0 -58878.125 -0.324141737821944 921120.0 -40202.5 -0.239883731752659 -0.9621 -0.9223 2071927 Maybridge1_004785 FC(F)(F)c1ccc(nc1)n2ccnc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B12 compound treatment 974080.0 125000.0 0.71 814110.0 -148000.0 -0.74 931150.0 72911.875 0.401401740805373 842190.0 -119132.5 -0.710850038505655 -0.1668 -0.1271 1042218 Maybridge1_004786 OC(=O)c1cc2cccc([N+](=O)[O-])c2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B13 compound treatment 646720.0 -202000.0 -1.16 556980.0 -405000.0 -2.02 673700.0 -184538.125 -1.0159377278387 647360.0 -313962.5 -1.87337842498337 -3.0347 -0.9608 2071928 Maybridge1_004787 O/N=C/c1ccc(C#Cc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B14 compound treatment 681800.0 -167000.0 -0.96 862270.0 -99500.0 -0.5 785770.0 -72468.125 -0.398958763958565 882210.0 -79112.5 -0.472055263435911 -1.1619 -0.9357 2071929 Maybridge1_004788 O/N=C/1\CCCc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B15 compound treatment 705240.0 -144000.0 -0.82 939530.0 -22200.0 -0.11 778210.0 -80028.125 -0.440578831478274 959160.0 -2162.5 -0.0129033908317922 -0.693 -0.7382 1076140 Maybridge1_004789 CSc1ncc(C#N)c(N)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B16 compound treatment 751650.0 -97400.0 -0.56 946030.0 -15700.0 -0.08 827400.0 -30838.125 -0.169773127603339 865660.0 -95662.5 -0.570807225639916 -0.6877 -0.84 2071930 Maybridge1_004790 CN(C)c1ncnc(N(C)C)c1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B17 compound treatment 700770.0 -148000.0 -0.85 769300.0 -192000.0 -0.96 757150.0 -101088.125 -0.556520448140323 809620.0 -151702.5 -0.905191513368763 -1.6356 -0.9822 2071931 Maybridge1_004791 COC(=O)C(C#N)c1ccc(cc1[N+](=O)[O-])C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B18 compound treatment 718880.0 -130000.0 -0.74 848170.0 -114000.0 -0.57 754670.0 -103568.125 -0.570173591982767 870880.0 -90442.5 -0.539660081065601 -1.2107 -0.9912 2071932 Maybridge1_004792 CCCCC#Cc1ccc(o1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B19 compound treatment 802440.0 -46600.0 -0.27 946180.0 -15600.0 -0.08 786170.0 -72068.125 -0.396756643983977 866080.0 -95242.5 -0.568301133547729 -0.6545 -0.8768 1585976 Maybridge1_004793 NC(=O)CCOC1CCN(Cc2ccccc2)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B20 compound treatment 744800.0 -104000.0 -0.6 924160.0 -37600.0 -0.19 799940.0 -58298.125 -0.320948663858792 954790.0 -6532.5 -0.0389786823623964 -0.5717 -0.8131 2071933 Maybridge1_004794 CCOC(=O)CCN(Cc1ccco1)S(=O)(=O)c2ccc(s2)c3ccnc(SC)n3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B21 compound treatment 727000.0 -122000.0 -0.7 759090.0 -203000.0 -1.01 710800.0 -147438.125 -0.811691100195685 752450.0 -208872.5 -1.24631838220278 -1.8844 -0.9763 2071934 Maybridge1_004795 CSc1nn(cc1C(=S)N)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B22 compound treatment 790890.0 -58100.0 -0.33 951320.0 -10400.0 -0.05 830010.0 -28228.125 -0.155404294769154 1085360.0 124037.5 0.74011761401083 0.1002 0.1211 1302174 Maybridge1_004796 Cc1ccccc1n2c(N)cc(=O)[nH]c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B23 mock treatment 928890.0 79900.0 0.46 1057720.0 96000.0 0.48 857440.0 -798.125 -0.00439391751179473 1142010.0 180687.5 1.07814170215928 1.005 0.7943 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 B24 mock treatment 981440.0 132000.0 0.76 961810.0 57.2 0.0 979700.0 121461.875 0.668684052720968 1064350.0 103027.5 0.614753340542181 1.0201 0.863 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C01 compound treatment 501140.0 -348000.0 -1.99 446330.0 -515000.0 -2.58 551410.0 -306828.125 -1.68918085706956 539690.0 -421632.5 -2.51583303347311 -4.3851 -0.986 2071935 Maybridge1_004797 CC1(C)CC(=O)c2c(sc(Br)c2C1)S(=O)(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C02 compound treatment 577520.0 -272000.0 -1.55 635910.0 -326000.0 -1.63 636170.0 -222068.125 -1.2225516344544 762190.0 -199132.5 -1.18820091320779 -2.7957 -0.9904 2071936 Maybridge1_004798 FC(F)(F)c1cnc(Sc2cccs2)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C03 compound treatment 652480.0 -197000.0 -1.12 693130.0 -269000.0 -1.34 749710.0 -108528.125 -0.597479879667656 815460.0 -145862.5 -0.870344899515507 -1.9671 -0.9621 1490688 Maybridge1_004799 CSc1sc(C(=S)N)c2CCCC(=O)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C04 compound treatment 117390.0 -732000.0 -4.18 137080.0 -825000.0 -4.12 49610.0 -808628.125 -4.45174036518996 63200.0 -898122.5 -5.35899451205838 -9.0574 -0.9941 3177144 Maybridge1_004800 CS(=N)c1ncc(Cl)cc1C(F)(F)F.Cc1cc(C)c(c(C)c1)S(=O)(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C05 compound treatment 697020.0 -152000.0 -0.87 747520.0 -214000.0 -1.07 735960.0 -122278.125 -0.673177753794111 844270.0 -117052.5 -0.6984389157634 -1.6557 -0.982 2071938 Maybridge1_004801 NNS(=O)(=O)c1ccc(s1)c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C06 compound treatment 721500.0 -128000.0 -0.73 744920.0 -217000.0 -1.08 726770.0 -131468.125 -0.723771460210266 831360.0 -129962.5 -0.775471413168457 -1.6561 -0.9841 2071939 Maybridge1_004802 CC(=O)c1ccc2OCCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C07 compound treatment 694190.0 -155000.0 -0.88 882690.0 -79100.0 -0.4 755100.0 -103138.125 -0.567806313010085 898820.0 -62502.5 -0.37294528807588 -1.1103 -0.9383 2071940 Maybridge1_004803 NC(=S)CSc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C08 compound treatment 656220.0 -193000.0 -1.1 670470.0 -291000.0 -1.46 746290.0 -111948.125 -0.616308005450381 751200.0 -210122.5 -1.25377698962 -2.2142 -0.9629 2071941 Maybridge1_004804 C1Cc2cc(ccc2O1)c3cc[nH]n3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C09 compound treatment 725440.0 -124000.0 -0.71 769440.0 -192000.0 -0.96 762260.0 -95978.125 -0.528388365464963 822780.0 -138542.5 -0.826667294480261 -1.5115 -0.9785 2071942 Maybridge1_004805 O=S(=O)(NCc1cccs1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C10 compound treatment 607220.0 -242000.0 -1.38 642090.0 -320000.0 -1.6 661200.0 -197038.125 -1.08475397704457 717690.0 -243632.5 -1.45372733726086 -2.7593 -0.9909 2071943 Maybridge1_004806 COC(=O)c1cccc(Cn2nc(C)c(Br)c2C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C11 compound treatment 580690.0 -268000.0 -1.53 650820.0 -311000.0 -1.56 577180.0 -281058.125 -1.54730927770674 671090.0 -290232.5 -1.73178422177485 -3.1836 -0.9987 1920568 Maybridge1_004807 Clc1ccc(NC(=O)c2cccs2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C12 compound treatment 705160.0 -144000.0 -0.82 755870.0 -206000.0 -1.03 747570.0 -110668.125 -0.6092612215317 793520.0 -167802.5 -1.00125837690257 -1.731 -0.9817 1087839 Maybridge1_004808 COc1ccc2nonc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C13 compound treatment 699590.0 -149000.0 -0.85 820110.0 -142000.0 -0.71 1037630.0 179391.875 0.987606078040647 836110.0 -125212.5 -0.747128704983018 -0.6608 -0.3975 1068635 Maybridge1_004809 O=S(=O)(c1cccs1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C14 compound treatment 666640.0 -182000.0 -1.04 719840.0 -242000.0 -1.21 729600.0 -128638.125 -0.708191461390058 791290.0 -170032.5 -1.01456453253489 -1.9873 -0.9838 2071944 Maybridge1_004810 Sc1nnc(CSCCOc2ccc(Cl)cc2Cl)o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C15 compound treatment 504410.0 -345000.0 -1.97 569850.0 -392000.0 -1.96 601300.0 -256938.125 -1.4145214432391 557210.0 -404112.5 -2.41129319191335 -3.8773 -0.9838 2071945 Maybridge1_004811 [O-][N+](=O)c1cc(cs1)S(=O)(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C16 compound treatment 608100.0 -241000.0 -1.38 651550.0 -310000.0 -1.55 722290.0 -135948.125 -0.74843520392565 691910.0 -269412.5 -1.60755365663362 -2.6419 -0.9682 2071946 Maybridge1_004812 C/C(=N\O)/c1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C17 compound treatment 654560.0 -194000.0 -1.11 672190.0 -290000.0 -1.45 675270.0 -182968.125 -1.00729440693845 509770.0 -451552.5 -2.69436226061171 -3.1304 -0.9189 2071947 Maybridge1_004813 CS(=O)(=O)c1sc(Cl)c2CCCC(=O)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C18 compound treatment 630880.0 -218000.0 -1.25 724480.0 -237000.0 -1.19 707720.0 -150518.125 -0.828647424000011 852970.0 -108352.5 -0.646527008139542 -1.954 -0.9691 2071948 Maybridge1_004814 [O-][N+](=O)c1ccc(N2CCCCC2)c3nonc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C19 compound treatment 662320.0 -187000.0 -1.07 759160.0 -203000.0 -1.01 750790.0 -107448.125 -0.591534155736269 799360.0 -161962.5 -0.966411763049312 -1.8189 -0.9795 2071949 Maybridge1_004815 CC1(C)CCc2cc(/C=C(\C#N)/S(=O)(=O)C)ccc2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C20 compound treatment 704180.0 -145000.0 -0.83 703840.0 -258000.0 -1.29 750670.0 -107568.125 -0.592194791728645 814450.0 -146872.5 -0.876371454308622 -1.793 -0.9629 1517114 Maybridge1_004816 CCOC(=O)Cc1n[nH]c(=O)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C21 compound treatment 610340.0 -239000.0 -1.36 645330.0 -316000.0 -1.58 688610.0 -169628.125 -0.933853705785943 740130.0 -221192.5 -1.31983041690691 -2.5999 -0.9842 2071950 Maybridge1_004817 CSc1sc(c2cc[nH]n2)c(c1C#N)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C22 compound treatment 621380.0 -228000.0 -1.3 645120.0 -317000.0 -1.58 646250.0 -211988.125 -1.16705821109479 754050.0 -207272.5 -1.23677136470874 -2.644 -0.9929 1032639 Maybridge1_004818 COc1cc(Cl)c(Cl)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C23 mock treatment 724820.0 -124000.0 -0.71 800480.0 -161000.0 -0.81 788230.0 -70008.125 -0.38541572611485 958970.0 -2352.5 -0.0140370991592097 -0.9578 -0.8391 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 C24 mock treatment 707680.0 -141000.0 -0.81 864010.0 -97700.0 -0.49 756240.0 -101998.125 -0.56153027108251 904210.0 -57112.5 -0.340783772892823 -1.0993 -0.956 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D01 compound treatment 780800.0 -68200.0 -0.39 734950.0 -227000.0 -1.13 789600.0 -68638.125 -0.377873465201887 772650.0 -188672.5 -1.12578728634049 -1.5139 -0.8969 2071951 Maybridge1_004819 Oc1cc(nc2cc(Cl)cc(Cl)c12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D02 compound treatment 518930.0 -330000.0 -1.89 661180.0 -301000.0 -1.5 571600.0 -286638.125 -1.57802885135224 682290.0 -279032.5 -1.66495509931655 -3.316 -0.9963 2071952 Maybridge1_004820 COc1ccc(cc1)C(=O)/C(=C/NC2CCN(Cc3ccccc3)CC2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D03 compound treatment 605790.0 -243000.0 -1.39 674080.0 -288000.0 -1.44 647960.0 -210278.125 -1.15764414820343 794610.0 -166712.5 -0.994754471234752 -2.4904 -0.9898 1578495 Maybridge1_004821 NC(=O)C1CCN(CCS(=O)(=O)c2ccc(Cl)cc2)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D04 compound treatment 575390.0 -274000.0 -1.56 588880.0 -373000.0 -1.86 615160.0 -243078.125 -1.33821798611963 635360.0 -325962.5 -1.94498105618869 -3.3556 -0.9897 2071953 Maybridge1_004822 COC(=O)c1cc(ccc1N2CCC(CC2)n3cccc3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D05 compound treatment 594000.0 -255000.0 -1.46 684530.0 -277000.0 -1.39 636510.0 -221728.125 -1.220679832476 725280.0 -236042.5 -1.40843867302349 -2.7363 -0.9979 2071954 Maybridge1_004823 [O-][N+](=O)c1c(Sc2ccc(cn2)C(F)(F)F)ncnc1Sc3ccc(cn3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D06 compound treatment 456360.0 -393000.0 -2.24 609800.0 -352000.0 -1.76 549820.0 -308418.125 -1.69793428396855 624410.0 -336912.5 -2.01031845716355 -3.8558 -0.9938 1005737 Maybridge1_004824 [O-][N+](=O)c1cccc(C=C(C#N)C#N)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D07 compound treatment 694450.0 -155000.0 -0.88 717250.0 -245000.0 -1.22 724180.0 -134058.125 -0.738030187045722 926310.0 -35012.5 -0.208915593756357 -1.5264 -0.902 2071955 Maybridge1_004825 NCCSc1cc(nc2ccccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D08 compound treatment 747650.0 -101000.0 -0.58 782580.0 -179000.0 -0.9 785240.0 -72998.125 -0.401876572924894 787540.0 -173782.5 -1.03694035478655 -1.457 -0.9454 1144898 Maybridge1_004826 Cc1nn(C)c2ncc3c(=O)[nH]n(C)c3c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D09 compound treatment 611010.0 -238000.0 -1.36 693050.0 -269000.0 -1.34 641730.0 -216508.125 -1.19194216680763 784640.0 -176682.5 -1.05424432399451 -2.4749 -0.995 2071956 Maybridge1_004827 CNc1ncnc(Oc2cccc(c2)C(F)(F)F)c1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D10 compound treatment 733840.0 -115000.0 -0.66 799680.0 -162000.0 -0.81 831870.0 -26368.125 -0.14516443688732 932560.0 -28762.5 -0.171622556670253 -0.8927 -0.8359 2071957 Maybridge1_004828 Cn1c(S)nnc1CSCC(=O)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D11 compound treatment 600800.0 -248000.0 -1.42 609160.0 -353000.0 -1.76 647490.0 -210748.125 -1.16023163917357 692320.0 -269002.5 -1.60510723340077 -2.9734 -0.9888 2071958 Maybridge1_004829 O=C(Nc1cccc(C#C)c1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D12 compound treatment 657380.0 -192000.0 -1.09 975610.0 13900.0 0.07 752800.0 -105438.125 -0.580468502863965 986400.0 25077.5 0.149634582004286 -0.7282 -0.5825 1634031 Maybridge1_004830 CCCn1c(=O)c(C#N)cn(c2ccc(Cl)cc2)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D13 compound treatment 684810.0 -164000.0 -0.94 741600.0 -220000.0 -1.1 733600.0 -124638.125 -0.68617026164418 793470.0 -167852.5 -1.00155672119926 -1.8635 -0.9867 2071959 Maybridge1_004831 CC(C)(O)C#Cc1ccc(/C=N/O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D14 compound treatment 678780.0 -170000.0 -0.97 740600.0 -221000.0 -1.11 711300.0 -146938.125 -0.80893845022745 841550.0 -119772.5 -0.714668845503272 -1.8011 -0.9864 1465353 Maybridge1_004832 COc1ccc(cc1OC2CCCC2)C(=O)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D15 compound treatment 672410.0 -177000.0 -1.01 835300.0 -126000.0 -0.63 789440.0 -68798.125 -0.378754313191722 956020.0 -5302.5 -0.0316394126638511 -1.0259 -0.8207 1914741 Maybridge1_004833 OC(=O)CSc1ccc(cc1[N+](=O)[O-])C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D16 compound treatment 691580.0 -157000.0 -0.9 746610.0 -215000.0 -1.08 735200.0 -123038.125 -0.677361781745828 806240.0 -155082.5 -0.925359587824928 -1.7891 -0.9876 2071960 Maybridge1_004834 CCCCC#Cc1cncc(c1)C(=O)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D17 compound treatment 618110.0 -231000.0 -1.32 691570.0 -270000.0 -1.35 670610.0 -187628.125 -1.03294910464239 781380.0 -179942.5 -1.07369637213862 -2.3885 -0.993 1341007 Maybridge1_004835 Clc1ccc(cc1Cl)C(=O)CSC2=NCCc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D18 compound treatment 656600.0 -192000.0 -1.1 756540.0 -205000.0 -1.03 715170.0 -143068.125 -0.787632939473313 782400.0 -178922.5 -1.06761014848617 -1.9904 -0.9925 2071961 Maybridge1_004836 Oc1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D19 compound treatment 787520.0 -61500.0 -0.35 868160.0 -93600.0 -0.47 743690.0 -114548.125 -0.630621785285202 815040.0 -146282.5 -0.872850991607693 -1.1615 -0.9477 2071962 Maybridge1_004837 CN(C)CC#Cc1cccc(/C=N/O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D20 compound treatment 639270.0 -210000.0 -1.2 760210.0 -202000.0 -1.01 685340.0 -172898.125 -0.951856036578198 793370.0 -167952.5 -1.00215340979263 -2.0801 -0.996 2071963 Maybridge1_004838 CCOC(=O)c1ccc2nonc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D21 compound treatment 643130.0 -206000.0 -1.18 779040.0 -183000.0 -0.91 681940.0 -176298.125 -0.970574056362195 768320.0 -193002.5 -1.15162390243374 -2.1061 -0.9943 2071964 Maybridge1_004839 NC(=O)C1CCN(CC1)c2ncc(Cl)cc2C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D22 compound treatment 637080.0 -212000.0 -1.21 700640.0 -261000.0 -1.31 719290.0 -138948.125 -0.764951103735058 797280.0 -164042.5 -0.978822885791568 -2.1302 -0.9811 2071965 Maybridge1_004840 Cn1c(SCC(=O)Nc2ccc(cc2)C(F)(F)F)nnc1c3ccc4nonc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D23 mock treatment 705120.0 -144000.0 -0.82 810470.0 -151000.0 -0.76 809650.0 -48588.125 -0.267492201475673 910480.0 -50842.5 -0.303371398088043 -1.0748 -0.9045 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 D24 mock treatment 759900.0 -89100.0 -0.51 1045780.0 84000.0 0.42 803320.0 -54918.125 -0.302340750073525 951870.0 -9452.5 -0.0564019892890245 -0.2238 -0.3073 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E01 compound treatment 674400.0 -175000.0 -1.0 680000.0 -282000.0 -1.41 820230.0 -38008.125 -0.209246128147825 816100.0 -145222.5 -0.86652609251789 -1.7413 -0.8961 1679279 Maybridge1_004841 CCOC(=O)c1sc(SCC=C)c2C(=O)CCCc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E02 compound treatment 234410.0 -615000.0 -3.51 412850.0 -549000.0 -2.75 218320.0 -639918.125 -3.52294121290819 382720.0 -578602.5 -3.45245511849805 -6.6159 -0.9952 2071966 Maybridge1_004842 CCOC(=O)c1ccc(Oc2sccc2[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E03 compound treatment 621790.0 -227000.0 -1.3 664570.0 -297000.0 -1.49 645080.0 -213158.125 -1.17349941202046 675920.0 -285402.5 -1.70296416271471 -2.8305 -0.9902 2071967 Maybridge1_004843 Clc1ccc(cc1)S(=O)(=O)CCN(Cc2cccs2)/C=C(\C#N)/S(=O)(=O)c3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E04 compound treatment 701120.0 -148000.0 -0.84 776970.0 -185000.0 -0.92 833220.0 -25018.125 -0.137732281973086 871680.0 -89642.5 -0.53488657231858 -1.2209 -0.892 2071968 Maybridge1_004844 FC(F)(F)c1cccc(NC(=O)Nc2cnn3c(cc(nc23)C(F)(F)F)C(F)(F)F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E05 compound treatment 654180.0 -195000.0 -1.11 700000.0 -262000.0 -1.31 732750.0 -125488.125 -0.690849766590179 775100.0 -186222.5 -1.11116841580274 -2.1121 -0.9779 2071969 Maybridge1_004845 Clc1ccc(/C=N/NS(=O)(=O)c2ccc(s2)c3ccccn3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E06 compound treatment 720930.0 -128000.0 -0.73 848000.0 -114000.0 -0.57 1056550.0 198311.875 1.09176635283865 816570.0 -144752.5 -0.863721656129015 -0.5363 -0.3207 1313983 Maybridge1_004846 CC(=O)N1CCSC1C(=O)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E07 compound treatment 748690.0 -100000.0 -0.57 1096120.0 134000.0 0.67 748850.0 -109388.125 -0.60221443761302 827440.0 -133882.5 -0.798861606028862 -0.6511 -0.4879 1397201 Maybridge1_004847 CCOC(=O)c1c(C)nsc1N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E08 compound treatment 781120.0 -67900.0 -0.39 770460.0 -191000.0 -0.96 769080.0 -89158.125 -0.490842219898241 832520.0 -128802.5 -0.768549825485276 -1.302 -0.9452 2071970 Maybridge1_004848 FC(F)(F)c1ccc(SCc2ccc(o2)C(=O)Oc3ccccc3)nc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E09 compound treatment 703620.0 -145000.0 -0.83 766960.0 -195000.0 -0.97 857880.0 -358.125 -0.00197158553974815 868890.0 -92432.5 -0.551534184073817 -1.1792 -0.8459 2071971 Maybridge1_004849 Cn1c(S)nnc1CSc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E10 compound treatment 783320.0 -65700.0 -0.38 750880.0 -211000.0 -1.05 762810.0 -95428.125 -0.525360450499905 861840.0 -99482.5 -0.593600729906943 -1.2745 -0.9291 1445026 Maybridge1_004850 Cc1nn(Cc2cccc(c2)C(=O)O)c(C)c1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E11 compound treatment 671380.0 -178000.0 -1.01 758000.0 -204000.0 -1.02 743160.0 -115078.125 -0.633539594251531 826180.0 -135142.5 -0.806379882305421 -1.7369 -0.9833 2071972 Maybridge1_004851 O=S(=O)(c1ccsc1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E12 compound treatment 650210.0 -199000.0 -1.14 635460.0 -326000.0 -1.63 687610.0 -170628.125 -0.939359005722413 750080.0 -211242.5 -1.26045990186583 -2.4838 -0.9799 2071973 Maybridge1_004852 Clc1ccc(SCC#N)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E13 compound treatment 955260.0 106000.0 0.61 1028160.0 66400.0 0.33 966690.0 108451.875 0.5970601005475 731270.0 -230052.5 -1.37269702628017 0.0817 0.0495 2071974 Maybridge1_004853 COC(=O)C1=C(CSC1)OS(=O)(=O)c2ccc(C)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E14 compound treatment 700060.0 -149000.0 -0.85 758450.0 -203000.0 -1.02 743200.0 -115038.125 -0.633319382254072 805710.0 -155612.5 -0.92852203736983 -1.7148 -0.9865 1552646 Maybridge1_004854 CS(=O)c1ccc(Oc2cccc(F)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E15 compound treatment 787620.0 -61400.0 -0.35 802500.0 -159000.0 -0.8 796850.0 -61388.125 -0.337960040662483 880270.0 -81052.5 -0.483631022147438 -0.9844 -0.9363 1323369 Maybridge1_004855 Cc1c(ncn1Cc2ccc(Cl)cc2)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E16 compound treatment 703910.0 -145000.0 -0.83 787220.0 -175000.0 -0.87 814450.0 -43788.125 -0.241066761780619 823440.0 -137882.5 -0.822729149763969 -1.3829 -0.9357 2071975 Maybridge1_004856 CC(=O)NCCc1ccc(OC(=O)C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E17 compound treatment 450830.0 -398000.0 -2.27 533930.0 -428000.0 -2.14 538460.0 -319778.125 -1.76047449124684 563000.0 -398322.5 -2.37674492235678 -4.2758 -0.9941 2071976 Maybridge1_004857 CS(=O)c1sc(Cl)c2CCCC(=O)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E18 compound treatment 635070.0 -214000.0 -1.22 649850.0 -312000.0 -1.56 687930.0 -170308.125 -0.937597309742742 993720.0 32397.5 0.193312187039531 -1.7633 -0.8012 2071977 Maybridge1_004858 [O-][N+](=O)c1ccc(N2CCCC2)c3nonc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E19 compound treatment 901620.0 52600.0 0.3 1070560.0 109000.0 0.54 1037130.0 178891.875 0.984853428072413 797060.0 -164262.5 -0.980135600696999 0.4247 0.279 2071978 Maybridge1_004859 O=C1CSC(C1)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E20 compound treatment 656750.0 -192000.0 -1.1 701930.0 -260000.0 -1.3 701700.0 -156538.125 -0.861789329617557 804730.0 -156592.5 -0.934369585584931 -2.097 -0.9874 2071979 Maybridge1_004860 CSc1nn2c(cc(nc2c1C(=O)N)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E21 compound treatment 186000.0 -663000.0 -3.79 78010.0 -884000.0 -4.42 211170.0 -647068.125 -3.56230410745395 125700.0 -835622.5 -4.98606414119734 -8.378 -0.9913 2071980 Maybridge1_004861 [O-][N+](=O)c1ccsc1Sc2ccc(cn2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E22 compound treatment 668750.0 -180000.0 -1.03 631250.0 -331000.0 -1.65 674520.0 -183718.125 -1.0114233818908 742400.0 -218922.5 -1.30628558583723 -2.5003 -0.979 2071981 Maybridge1_004862 N/C(=N\O)/COc1ccc2nonc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E23 mock treatment 794720.0 -54300.0 -0.31 883040.0 -78700.0 -0.39 829940.0 -28298.125 -0.155789665764706 889000.0 -72322.5 -0.431540107945567 -0.6456 -0.9501 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 E24 mock treatment 1011730.0 163000.0 0.93 813390.0 -148000.0 -0.74 907360.0 49121.875 0.270430655316764 975200.0 13877.5 0.0828054595459864 0.2703 0.2211 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F01 compound treatment 686100.0 -163000.0 -0.93 736230.0 -226000.0 -1.13 764800.0 -93438.125 -0.514404903626331 817800.0 -143522.5 -0.856382386430469 -1.7147 -0.9682 2071982 Maybridge1_004863 Oc1cc(nc2cc(Cl)ccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F02 compound treatment 663010.0 -186000.0 -1.06 752190.0 -210000.0 -1.05 779960.0 -78278.125 -0.430944556589453 804010.0 -157312.5 -0.93866574345725 -1.7402 -0.9587 1426067 Maybridge1_004864 O=C(N1CCC(CC1)n2cccc2)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F03 compound treatment 726020.0 -123000.0 -0.7 751430.0 -210000.0 -1.05 739200.0 -119038.125 -0.65534058199995 823110.0 -138212.5 -0.824698222122115 -1.6173 -0.9825 1407522 Maybridge1_004865 NC(=O)C1CCN(CCC#N)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F04 compound treatment 708720.0 -140000.0 -0.8 688390.0 -273000.0 -1.37 735880.0 -122358.125 -0.673618177789029 789760.0 -171562.5 -1.02369386801357 -1.933 -0.9649 2071983 Maybridge1_004866 [O-][N+](=O)c1cc(ccc1N2CCC(CC2)n3cccc3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F05 compound treatment 668540.0 -180000.0 -1.03 664560.0 -297000.0 -1.49 733000.0 -125238.125 -0.689473441606061 779970.0 -181352.5 -1.08210968130524 -2.1445 -0.9669 2071984 Maybridge1_004867 CSc1nn(c(N)c1C#N)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F06 compound treatment 643160.0 -206000.0 -1.18 834400.0 -127000.0 -0.64 803690.0 -54548.125 -0.300303789097031 870010.0 -91312.5 -0.544851271827987 -1.3291 -0.901 1579683 Maybridge1_004868 CCCn1c(=O)c(C#N)nn(c2ccccc2)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F07 compound treatment 728100.0 -121000.0 -0.69 761800.0 -200000.0 -1.0 789440.0 -68798.125 -0.378754313191722 793860.0 -167462.5 -0.999229635685084 -1.5344 -0.9481 1545160 Maybridge1_004869 CCOC(=O)NC(=O)c1cn(C(C)C)c(=O)n(Cc2ccccc2)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F08 compound treatment 658430.0 -191000.0 -1.09 683690.0 -278000.0 -1.39 683970.0 -174268.125 -0.959398297491162 769530.0 -191792.5 -1.14440397045387 -2.2917 -0.9908 2071985 Maybridge1_004870 NS(=O)(=O)c1cc([N+](=O)[O-])c(s1)N2CCNCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F09 compound treatment 693710.0 -155000.0 -0.89 751380.0 -210000.0 -1.05 721860.0 -136378.125 -0.750802482898332 840510.0 -120812.5 -0.7208744068744 -1.7056 -0.9884 1229841 Maybridge1_004871 Cc1[nH]c2ccccc2c1SCc3nnc(S)n3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F10 compound treatment 725980.0 -123000.0 -0.7 827440.0 -134000.0 -0.67 773650.0 -84588.125 -0.465682999188575 849540.0 -111782.5 -0.666993426892396 -1.2537 -0.9889 1160768 Maybridge1_004872 OC(=O)c1c(nnc2ccccc12)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F11 compound treatment 571170.0 -278000.0 -1.59 634270.0 -327000.0 -1.64 621300.0 -236938.125 -1.30441544450971 680120.0 -281202.5 -1.67790324179285 -3.1038 -0.9956 2071986 Maybridge1_004873 CC(=O)c1ccc(C#Cc2ccccc2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F12 compound treatment 596000.0 -253000.0 -1.45 658180.0 -304000.0 -1.52 603300.0 -254938.125 -1.40351084336616 755090.0 -206232.5 -1.23056580333761 -2.7989 -0.9972 2071987 Maybridge1_004874 Cc1ccc2snc(C(=O)N)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F13 compound treatment 728200.0 -121000.0 -0.69 785460.0 -176000.0 -0.88 748860.0 -109378.125 -0.602159384613655 804690.0 -156632.5 -0.934608261022282 -1.5544 -0.985 2071988 Maybridge1_004875 NC(CC(=O)O)c1ccccc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F14 compound treatment 718050.0 -131000.0 -0.75 737970.0 -224000.0 -1.12 720650.0 -137588.125 -0.75746389582146 830130.0 -131192.5 -0.782810682867003 -1.7039 -0.9839 2071989 Maybridge1_004876 OC(=O)c1cc2cc(OC(F)(F)F)ccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F15 compound treatment 709810.0 -139000.0 -0.8 774630.0 -187000.0 -0.94 785440.0 -72798.125 -0.4007755129376 853990.0 -107332.5 -0.64044078448709 -1.3862 -0.9613 1013621 Maybridge1_004877 CSc1ncc(C(=O)N)c(N)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F16 compound treatment 558110.0 -291000.0 -1.66 611550.0 -350000.0 -1.75 614720.0 -243518.125 -1.34064031809168 686210.0 -275112.5 -1.64156490645615 -3.1978 -0.9953 2071990 Maybridge1_004878 CSc1nccc(n1)c2ccc(s2)S(=O)(=O)N(CCC#N)Cc3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F17 compound treatment 706080.0 -143000.0 -0.82 749480.0 -212000.0 -1.06 719200.0 -139038.125 -0.765446580729341 822570.0 -138752.5 -0.827920340526355 -1.7358 -0.9914 1635590 Maybridge1_004879 O=C(Nc1ccccc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F18 compound treatment 663040.0 -186000.0 -1.06 703200.0 -259000.0 -1.29 755770.0 -102468.125 -0.56411776205265 869810.0 -91512.5 -0.546044649014742 -1.7329 -0.9374 2071991 Maybridge1_004880 Cc1cccc2c(O)cc(nc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F19 compound treatment 754560.0 -94500.0 -0.54 867620.0 -94100.0 -0.47 800430.0 -57808.125 -0.318251066889922 874010.0 -87312.5 -0.52098372809288 -0.9248 -0.9828 2071992 Maybridge1_004881 NNC(=O)CN1C(=O)CSc2ccc(cc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F20 compound treatment 698850.0 -150000.0 -0.86 787200.0 -175000.0 -0.87 741650.0 -116588.125 -0.6418525971556 839440.0 -121882.5 -0.727258974823541 -1.55 -0.9925 2071993 Maybridge1_004882 CCOC1O[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O1)n3cnc4c(N)ncnc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F21 compound treatment 614020.0 -235000.0 -1.34 587860.0 -374000.0 -1.87 617050.0 -241188.125 -1.3278129692397 660010.0 -301312.5 -1.7978973179211 -3.1691 -0.9877 2071994 Maybridge1_004883 N#Cc1cncc(C#Cc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F22 compound treatment 718260.0 -131000.0 -0.75 731360.0 -230000.0 -1.15 762140.0 -96098.125 -0.52904900145734 731640.0 -229682.5 -1.37048927848467 -1.8994 -0.9445 2071995 Maybridge1_004884 COC(=O)c1c(C)oc(=O)c(Br)c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F23 mock treatment 792570.0 -56500.0 -0.32 1015790.0 54000.0 0.27 788800.0 -69438.125 -0.382277705151062 879360.0 -81962.5 -0.489060888347175 -0.4618 -0.6158 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 F24 mock treatment 736440.0 -113000.0 -0.64 1000160.0 38400.0 0.19 805440.0 -52798.125 -0.29066951420821 934080.0 -27242.5 -0.162552890050912 -0.4521 -0.6034 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G01 compound treatment 746400.0 -103000.0 -0.59 927970.0 -33800.0 -0.17 929150.0 70911.875 0.390391140932434 1033330.0 72007.5 0.429660538876427 0.0324 0.0385 2071996 Maybridge1_004885 NS(=O)(=O)c1ccc(Br)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G02 compound treatment 668340.0 -181000.0 -1.03 783290.0 -178000.0 -0.89 745600.0 -112638.125 -0.620106662406545 872970.0 -88352.5 -0.527189289464008 -1.536 -0.9667 2071997 Maybridge1_004886 [O-][N+](=O)c1ccsc1NCc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G03 compound treatment 608320.0 -241000.0 -1.38 619420.0 -342000.0 -1.71 490200.0 -368038.125 -2.02616026618086 685440.0 -275882.5 -1.64615940862516 -3.3798 -0.9907 2071998 Maybridge1_004887 CSc1sc(c2CC(C)(C)CC(=O)c12)c3ccnc(S)n3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G04 compound treatment 714260.0 -135000.0 -0.77 741800.0 -220000.0 -1.1 711530.0 -146708.125 -0.807672231242062 789840.0 -171482.5 -1.02321651713887 -1.8504 -0.9888 2071999 Maybridge1_004888 Sc1nccc(n1)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G05 compound treatment 742760.0 -106000.0 -0.61 671220.0 -291000.0 -1.45 659730.0 -198508.125 -1.09284676795118 740420.0 -220902.5 -1.31810001998611 -2.2356 -0.961 2072000 Maybridge1_004889 Cn1nc(cc1N)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G06 compound treatment 569720.0 -279000.0 -1.6 627120.0 -335000.0 -1.67 571970.0 -286268.125 -1.57599189037575 709780.0 -251542.5 -1.50092540499703 -3.1731 -0.9993 2072001 Maybridge1_004890 FC(F)(F)c1cnc(N2CCSCC2)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G07 compound treatment 728320.0 -121000.0 -0.69 712030.0 -250000.0 -1.25 718330.0 -139908.125 -0.770236191674069 829500.0 -131822.5 -0.786569821005282 -1.7477 -0.9698 2072002 Maybridge1_004891 CN1c2sc(C)c(C)c2C(=O)CS1(=O)=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G08 compound treatment 708690.0 -140000.0 -0.8 770140.0 -192000.0 -0.96 757050.0 -101188.125 -0.557070978133969 843240.0 -118082.5 -0.70458480827519 -1.5108 -0.9818 1408174 Maybridge1_004892 COC(=O)C1SCCN1C(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G09 compound treatment 673560.0 -175000.0 -1.0 695290.0 -266000.0 -1.33 626000.0 -232238.125 -1.2785405348083 714510.0 -246812.5 -1.47270203453027 -2.5432 -0.9911 2072003 Maybridge1_004893 CCOC(=O)c1sc(SC)c2/C(=N\OC)/CCCc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G10 compound treatment 691140.0 -158000.0 -0.9 712840.0 -249000.0 -1.24 761090.0 -97148.125 -0.534829566390633 808320.0 -153002.5 -0.912948465082673 -1.7973 -0.9631 2072004 Maybridge1_004894 C/C(=N\OCC(=O)O)/c1cccs1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G11 compound treatment 730410.0 -119000.0 -0.68 718340.0 -243000.0 -1.22 769540.0 -88698.125 -0.488309781927465 821840.0 -139482.5 -0.832276167258012 -1.6078 -0.9487 2072005 Maybridge1_004895 Cc1nn(Cc2nnc(S)o2)c(C)c1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G12 compound treatment 663280.0 -186000.0 -1.06 870850.0 -90900.0 -0.45 751110.0 -107128.125 -0.589772459756598 770560.0 -190762.5 -1.13825807794208 -1.6219 -0.9402 2072006 Maybridge1_004896 Clc1ccc(c(Cl)c1)S(=O)(=O)CC#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G13 compound treatment 708970.0 -140000.0 -0.8 714640.0 -247000.0 -1.24 1020930.0 162691.875 0.895667569101606 740000.0 -221322.5 -1.3206061120783 -1.2305 -0.5667 2072007 Maybridge1_004897 FC(F)(F)Oc1ccc(cc1)C(=O)CC#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G14 compound treatment 635880.0 -213000.0 -1.22 572590.0 -389000.0 -1.95 658400.0 -199838.125 -1.10016881686669 676200.0 -285122.5 -1.70129343465325 -2.9827 -0.9741 2072008 Maybridge1_004898 CC1(C)Oc2ccc(C#N)cc2C=C1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G15 compound treatment 540900.0 -308000.0 -1.76 748320.0 -213000.0 -1.07 595690.0 -262548.125 -1.44540617588269 607790.0 -353532.5 -2.10948810138292 -3.1913 -0.9721 2072009 Maybridge1_004899 CSc1sc(Cl)c2CC(C)(C)CC(=O)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G16 compound treatment 673680.0 -175000.0 -1.0 680580.0 -281000.0 -1.41 662690.0 -195548.125 -1.07655108013923 718970.0 -242352.5 -1.44608972326562 -2.4653 -0.9876 2072010 Maybridge1_004900 C/C(=N\OCc1cccc(c1)C(=O)O)/c2ccc(Cl)c(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G17 compound treatment 693630.0 -155000.0 -0.89 761650.0 -200000.0 -1.0 713120.0 -145118.125 -0.798918804343075 849010.0 -112312.5 -0.670155876437298 -1.6788 -0.9898 2072011 Maybridge1_004901 CSc1scc2CCc3cnc(S)nc3-c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G18 compound treatment 475110.0 -374000.0 -2.14 394560.0 -567000.0 -2.84 508800.0 -349438.125 -1.92376168736253 480610.0 -480712.5 -2.86835665444064 -4.8825 -0.9856 1931686 Maybridge1_004902 Cc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G19 compound treatment 646750.0 -202000.0 -1.16 686520.0 -275000.0 -1.38 714090.0 -144148.125 -0.7935786634047 751250.0 -210072.5 -1.25347864532331 -2.2896 -0.9824 2072012 Maybridge1_004903 CN1c2ccccc2C(=O)/C(=C/N=S(=O)(C)C)/S1(=O)=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G20 compound treatment 671550.0 -177000.0 -1.01 764860.0 -197000.0 -0.98 688820.0 -169418.125 -0.932697592799285 757480.0 -203842.5 -1.21630494595588 -2.0738 -0.9947 1025517 Maybridge1_004904 NNC(=O)C1COc2ccccc2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G21 compound treatment 695460.0 -154000.0 -0.88 740410.0 -221000.0 -1.11 701720.0 -156518.125 -0.861679223618828 926720.0 -34602.5 -0.206469170523509 -1.5262 -0.9153 1593337 Maybridge1_004905 Cc1cc(C)n(n1)c2ncc(C#N)c(N)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G22 compound treatment 584190.0 -265000.0 -1.51 529360.0 -432000.0 -2.16 620660.0 -237578.125 -1.30793883646905 592340.0 -368982.5 -2.20167648905977 -3.5926 -0.9769 2072013 Maybridge1_004906 Cc1ccc2nc(cc(O)c2c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G23 mock treatment 747680.0 -101000.0 -0.58 769140.0 -193000.0 -0.96 759860.0 -98378.125 -0.54160108531249 864660.0 -96662.5 -0.576774111573692 -1.3303 -0.9679 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 G24 mock treatment 985690.0 137000.0 0.78 1000110.0 38400.0 0.19 905140.0 46901.875 0.258208889457801 868480.0 -92842.5 -0.553980607306665 0.3384 0.3351 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H01 compound treatment 576110.0 -273000.0 -1.56 574480.0 -387000.0 -1.94 625760.0 -232478.125 -1.27986180679305 666600.0 -294722.5 -1.75857553961751 -3.2672 -0.989 2072014 Maybridge1_004907 CC(C)Oc1cc(nc2ccc(CSCCO)cc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H02 compound treatment 673700.0 -175000.0 -1.0 694200.0 -268000.0 -1.34 723580.0 -134658.125 -0.741333367007604 809390.0 -151932.5 -0.906563897133532 -1.9938 -0.9769 1164963 Maybridge1_004908 Fc1ccc(cc1)S(=O)(=O)Cc2noc(n2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H03 compound treatment 677820.0 -171000.0 -0.98 746940.0 -215000.0 -1.07 701760.0 -156478.125 -0.861459011621369 797640.0 -163682.5 -0.976674806855408 -1.9453 -0.997 2072015 Maybridge1_004909 NC(=O)C1CCN(CC1)c2ccc(cn2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H04 compound treatment 583490.0 -266000.0 -1.52 671250.0 -291000.0 -1.45 643720.0 -214518.125 -1.18098661993406 718080.0 -243242.5 -1.45140025174668 -2.8011 -0.9958 2072016 Maybridge1_004910 [O-][N+](=O)c1ccc(N2CCC(CC2)n3cccc3)c(C#N)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H05 compound treatment 688450.0 -161000.0 -0.92 727750.0 -234000.0 -1.17 682170.0 -176068.125 -0.969307837376807 787300.0 -174022.5 -1.03837240741066 -2.0477 -0.9957 2072017 Maybridge1_004911 CSc1nn(cc1C#N)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H06 compound treatment 755800.0 -93200.0 -0.53 784590.0 -177000.0 -0.89 779170.0 -79068.125 -0.435293743539264 818310.0 -143012.5 -0.853339274604243 -1.3536 -0.9604 2072018 Maybridge1_004912 CCCn1c(=O)c(nn(c2cccc(c2)C(F)(F)F)c1=O)/C(=N/O)/N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H07 compound treatment 833820.0 -15200.0 -0.09 727680.0 -234000.0 -1.17 705370.0 -152868.125 -0.841584878850714 1048810.0 87487.5 0.522027933131291 -0.7886 -0.5134 2072019 Maybridge1_004913 COc1ccc(cc1)S(=O)(=O)NCCSc2cc(nc3ccccc23)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H08 compound treatment 704970.0 -144000.0 -0.82 700210.0 -262000.0 -1.31 676590.0 -181648.125 -1.00002741102231 738810.0 -222512.5 -1.32770670633949 -2.2294 -0.9823 2072020 Maybridge1_004914 CC(=O)c1ccc(C#Cc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H09 compound treatment 25840.0 -823000.0 -4.7 23900.0 -938000.0 -4.69 23260.0 -834978.125 -4.59680501851594 26020.0 -935302.5 -5.5808433310762 -9.7854 -0.9967 2072021 Maybridge1_004915 Clc1ccc(SCC2N3CCC(CC3)C2=O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H10 compound treatment 732710.0 -116000.0 -0.66 750840.0 -211000.0 -1.05 724180.0 -134058.125 -0.738030187045722 826010.0 -135312.5 -0.807394252914163 -1.6324 -0.9842 2072022 Maybridge1_004916 CC(C)(C)c1cc2nc(cc(N3CCN(CC3)c4cc(nc5cc(nn45)C(C)(C)C)C(F)(F)F)n2n1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H11 compound treatment 715520.0 -134000.0 -0.76 757990.0 -204000.0 -1.02 713070.0 -145168.125 -0.799194069339899 839490.0 -121832.5 -0.726960630526852 -1.654 -0.9907 1619884 Maybridge1_004917 Cn1ccnc1SCc2nccn2Cc3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H12 compound treatment 620980.0 -228000.0 -1.3 970440.0 8690.0 0.04 681450.0 -176788.125 -0.973271653331065 962970.0 1647.5 0.00983044457589715 -1.1114 -0.6832 2072023 Maybridge1_004918 OC(=O)CSc1ccc(F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H13 compound treatment 491160.0 -358000.0 -2.04 637700.0 -324000.0 -1.62 543310.0 -314928.125 -1.73377378655496 469640.0 -491682.5 -2.93381339313417 -4.1663 -0.9708 2072024 Maybridge1_004919 CC(C)(O)C#Cc1ccc(/C=N/Nc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H14 compound treatment 726500.0 -123000.0 -0.7 774330.0 -187000.0 -0.94 1167040.0 308801.875 1.70004694281917 864810.0 -96512.5 -0.575879078683626 -0.2566 -0.1198 1019296 Maybridge1_004920 NC(=O)CCSCCC(=O)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H15 compound treatment 626000.0 -223000.0 -1.27 654620.0 -307000.0 -1.54 617630.0 -240608.125 -1.32461989527655 736160.0 -225162.5 -1.343518954064 -2.7392 -0.9974 2072025 Maybridge1_004921 Cc1c(Br)sc2ccc(Cl)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H16 compound treatment 683300.0 -166000.0 -0.95 710640.0 -251000.0 -1.26 716640.0 -141598.125 -0.779540148566703 769990.0 -191332.5 -1.14165920292433 -2.0619 -0.9847 2072026 Maybridge1_004922 CCCCCCC#Cc1cncc(c1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H17 compound treatment 865450.0 16400.0 0.09 806880.0 -155000.0 -0.77 721350.0 -136888.125 -0.753610185865931 839410.0 -121912.5 -0.727437981401554 -1.0809 -0.8276 1555072 Maybridge1_004923 Clc1cc(Cl)cc(NC(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H18 compound treatment 588450.0 -261000.0 -1.49 574330.0 -387000.0 -1.94 570010.0 -288228.125 -1.58678227825123 608920.0 -352402.5 -2.10274552027775 -3.5579 -0.9902 2072027 Maybridge1_004924 Oc1cc(nc2ccc(cc12)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H19 compound treatment 639810.0 -209000.0 -1.2 712980.0 -249000.0 -1.24 705570.0 -152668.125 -0.84048381886342 779680.0 -181642.5 -1.08384007822604 -2.1819 -0.99 1254018 Maybridge1_004925 OC(=O)c1cncc(C#Cc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H20 compound treatment 685890.0 -163000.0 -0.93 775960.0 -186000.0 -0.93 741120.0 -117118.125 -0.644770406121929 828330.0 -132992.5 -0.793551077547801 -1.6497 -0.9899 2072028 Maybridge1_004926 NNC(=O)c1ccc2nonc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H21 compound treatment 680660.0 -168000.0 -0.96 684390.0 -277000.0 -1.39 682900.0 -175338.125 -0.965288968423184 784810.0 -176512.5 -1.05322995338576 -2.1838 -0.9875 1012399 Maybridge1_004927 [O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H22 compound treatment 706360.0 -143000.0 -0.81 836890.0 -125000.0 -0.62 787430.0 -70808.125 -0.389819966064026 885920.0 -75402.5 -0.449918116621599 -1.1396 -0.9602 2072029 Maybridge1_004928 FC(F)(F)c1cc(no1)c2ccc(s2)S(=O)(=O)N3CCC(CC3)C(c4ccccc4)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H23 mock treatment 938530.0 89500.0 0.51 1075410.0 114000.0 0.57 804580.0 -53658.125 -0.295404072153573 904060.0 -57262.5 -0.34167880578289 0.2213 0.2492 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 H24 mock treatment 985600.0 137000.0 0.78 1077520.0 116000.0 0.58 852910.0 -5328.125 -0.0293329262240016 1019930.0 58607.5 0.349704267363819 0.8398 0.813 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I01 compound treatment 892280.0 43300.0 0.25 876340.0 -85400.0 -0.43 978730.0 120491.875 0.663343911782593 1071850.0 110527.5 0.659504985045507 0.5714 0.5402 2072030 Maybridge1_004929 Cc1cc(O)c2nncn2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I02 compound treatment 745730.0 -103000.0 -0.59 742340.0 -219000.0 -1.1 735260.0 -122978.125 -0.67703146374964 858240.0 -103082.5 -0.615081519268539 -1.4898 -0.9638 2072031 Maybridge1_004930 Clc1ccc(cc1)S(=O)(=O)CCC2CCCCC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I03 compound treatment 512640.0 -336000.0 -1.92 600320.0 -361000.0 -1.81 552000.0 -306238.125 -1.68593273010704 667480.0 -293842.5 -1.75332467999579 -3.5843 -0.9988 2072032 Maybridge1_004931 CSc1scc2CC(C)(C)C/C(=N/O)/c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I04 compound treatment 612890.0 -236000.0 -1.35 704980.0 -257000.0 -1.28 620640.0 -237598.125 -1.30804894246778 683330.0 -277992.5 -1.65874953794543 -2.8 -0.9942 2072033 Maybridge1_004932 NS(=O)(=O)c1ccc(Sc2cccs2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I05 compound treatment 28350.0 -821000.0 -4.69 27570.0 -934000.0 -4.67 27460.0 -830778.125 -4.57368275878276 28660.0 -932662.5 -5.56509075221103 -9.7496 -0.9966 2072034 Maybridge1_004933 CC1(C)CC(=O)C=C(Sc2ccc(C#N)cc2[N+](=O)[O-])S1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I06 compound treatment 652960.0 -196000.0 -1.12 707950.0 -254000.0 -1.27 717070.0 -141168.125 -0.777172869594021 758050.0 -203272.5 -1.21290382097363 -2.1898 -0.9851 2072035 Maybridge1_004934 CC(=O)CSc1sc(C(=O)C)c(c1C#N)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I07 compound treatment 564260.0 -285000.0 -1.63 568560.0 -393000.0 -1.97 579520.0 -278718.125 -1.5344268758554 672890.0 -288432.5 -1.72104382709405 -3.4244 -0.9956 2072036 Maybridge1_004935 CSc1nccc(n1)c2ccc(Br)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I08 compound treatment 674500.0 -175000.0 -1.0 722370.0 -239000.0 -1.2 755110.0 -103128.125 -0.56775126001072 800800.0 -160522.5 -0.957819447304674 -1.8599 -0.9712 2072037 Maybridge1_004936 CCOC(=O)c1cnc(SCC(=O)c2ccc(Cl)cc2Cl)[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I09 compound treatment 543040.0 -306000.0 -1.75 536760.0 -425000.0 -2.13 504280.0 -353958.125 -1.94864564307537 655730.0 -305592.5 -1.82343558971766 -3.8228 -0.9972 1569480 Maybridge1_004937 COC(=O)C1=C(CSC1)Nc2ccc(O)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I10 compound treatment 597050.0 -252000.0 -1.44 641340.0 -320000.0 -1.6 646920.0 -211318.125 -1.16336966013736 693650.0 -267672.5 -1.59717127510885 -2.9013 -0.9925 1043570 Maybridge1_004938 Nc1cccc2nsnc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I11 compound treatment 635470.0 -214000.0 -1.22 703650.0 -258000.0 -1.29 808920.0 -49318.125 -0.271511070429296 732010.0 -229312.5 -1.36828153068917 -2.0753 -0.9189 2072038 Maybridge1_004939 CN1c2ccccc2C(=C(C(=O)Nc3ccc(OC(F)(F)F)cc3)S1(=O)=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I12 compound treatment 718520.0 -131000.0 -0.75 845890.0 -116000.0 -0.58 741010.0 -117228.125 -0.64537598911494 919260.0 -42062.5 -0.250982139589483 -1.1107 -0.9485 2072039 Maybridge1_004940 CSc1ccc(OS(=O)(=O)c2cc(cs2)S(=O)(=O)c3ccccc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I13 compound treatment 697570.0 -151000.0 -0.87 626160.0 -336000.0 -1.68 647360.0 -210878.125 -1.16094732816531 714980.0 -246342.5 -1.46989759814139 -2.5873 -0.9727 2072040 Maybridge1_004941 COC(=O)c1cscc1Sc2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I14 compound treatment 685010.0 -164000.0 -0.94 751800.0 -210000.0 -1.05 753990.0 -104248.125 -0.573917195939566 815610.0 -145712.5 -0.86944986662544 -1.7152 -0.9796 1068477 Maybridge1_004942 Clc1ccc2nsnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I15 compound treatment 601530.0 -247000.0 -1.41 612250.0 -350000.0 -1.75 626720.0 -231518.125 -1.27457671885404 672440.0 -288882.5 -1.72372892576425 -3.0801 -0.9915 2072041 Maybridge1_004943 CSc1sc(c(C)c1c2cc[nH]n2)c3nc(C)cs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I16 compound treatment 637120.0 -212000.0 -1.21 674660.0 -287000.0 -1.44 704960.0 -153278.125 -0.843842051824667 745440.0 -215882.5 -1.28814625259855 -2.3892 -0.9837 2072042 Maybridge1_004944 C/C(=N\OCc1cccc(c1)C(=O)O)/c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I17 compound treatment 704410.0 -145000.0 -0.83 764050.0 -198000.0 -0.99 771930.0 -86308.125 -0.475152115079303 860260.0 -101062.5 -0.60302840968231 -1.4466 -0.9644 2072043 Maybridge1_004945 CSc1nc(N)nc(n1)c2cnccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I18 compound treatment 22170.0 -827000.0 -4.72 25630.0 -936000.0 -4.68 23470.0 -834768.125 -4.59564890552928 27840.0 -933482.5 -5.56998359867673 -9.7856 -0.9968 2072044 Maybridge1_004946 OCCSc1ccc([N+](=O)[O-])c2nonc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I19 compound treatment 649820.0 -199000.0 -1.14 674480.0 -287000.0 -1.44 732410.0 -125828.125 -0.692721568568578 762960.0 -198362.5 -1.18360641103878 -2.2256 -0.9722 2072045 Maybridge1_004947 C1CSC(S1)C2CSC(C2)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I20 compound treatment 712710.0 -136000.0 -0.78 777130.0 -185000.0 -0.92 734900.0 -123338.125 -0.679013371726769 833120.0 -128202.5 -0.76496969392501 -1.5731 -0.9938 1153413 Maybridge1_004948 CCOC(=O)Cc1nn(CC(=S)N)c(=O)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I21 compound treatment 691960.0 -157000.0 -0.9 841620.0 -120000.0 -0.6 680390.0 -177848.125 -0.979107271263723 874770.0 -86552.5 -0.51644889478321 -1.4968 -0.9679 2072046 Maybridge1_004949 CSc1nnc(n1C)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I22 compound treatment 766990.0 -82000.0 -0.47 753290.0 -208000.0 -1.04 840830.0 -17408.125 -0.0958369494565534 842400.0 -118922.5 -0.709596992459562 -1.1584 -0.8588 2072047 Maybridge1_004950 Clc1ccc(OC(=O)c2csc(COc3ccc4nonc4c3)n2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I23 mock treatment 840320.0 -8710.0 -0.05 835840.0 -126000.0 -0.63 772590.0 -85648.125 -0.471518617121233 891970.0 -69352.5 -0.41381845672225 -0.7824 -0.8788 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 I24 mock treatment 949280.0 100000.0 0.57 1093140.0 131000.0 0.66 914080.0 55841.875 0.307426270889839 893160.0 -68162.5 -0.406717862461056 0.5653 0.5598 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J01 compound treatment 719200.0 -130000.0 -0.74 753770.0 -208000.0 -1.04 766360.0 -91878.125 -0.505816635725438 901660.0 -59662.5 -0.355999332023954 -1.3218 -0.9313 1736035 Maybridge1_004951 Cc1nn(Cc2ccc(o2)C(=O)O)c(C)c1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J02 compound treatment 674720.0 -174000.0 -1.0 851390.0 -110000.0 -0.55 724380.0 -133858.125 -0.736929127058429 813200.0 -148122.5 -0.883830061725842 -1.5842 -0.9787 2072048 Maybridge1_004952 Fc1ccc(cc1)S(=O)(=O)Cc2noc(n2)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J03 compound treatment 691480.0 -158000.0 -0.9 610010.0 -352000.0 -1.76 724740.0 -133498.125 -0.734947219081299 802470.0 -158852.5 -0.947854747795267 -2.171 -0.9392 1428447 Maybridge1_004953 CCOC(=O)NC(=O)c1cn(Cc2cccs2)c(=O)[nH]c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J04 compound treatment 722270.0 -127000.0 -0.72 807900.0 -154000.0 -0.77 725830.0 -132408.125 -0.728946442150548 865960.0 -95362.5 -0.569017159859783 -1.3958 -0.9941 2072049 Maybridge1_004954 O=C1NC(=O)N2CSCC21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J05 compound treatment 736130.0 -113000.0 -0.64 738270.0 -223000.0 -1.12 822500.0 -35738.125 -0.19674909729204 819560.0 -141762.5 -0.845880667187022 -1.4027 -0.9017 2072050 Maybridge1_004955 CC(C)n1cc(C#N)c(=O)[nH]c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J06 compound treatment 758670.0 -90400.0 -0.52 855270.0 -106000.0 -0.53 829010.0 -29228.125 -0.160909594705623 828690.0 -132632.5 -0.791402998611641 -1.0005 -0.9125 1270484 Maybridge1_004956 CCOC(=O)c1c(Oc2ccccc2)c3cc(Cl)ccc3nc1SC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J07 compound treatment 669860.0 -179000.0 -1.02 725280.0 -236000.0 -1.18 742080.0 -116158.125 -0.639485318182918 804690.0 -156632.5 -0.934608261022282 -1.8902 -0.9788 2072051 Maybridge1_004957 CC(=O)c1ccc(C#CC(C)(C)O)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J08 compound treatment 671170.0 -178000.0 -1.02 732130.0 -230000.0 -1.15 726080.0 -132158.125 -0.72757011716643 823730.0 -137592.5 -0.820998752843173 -1.8565 -0.9847 2072052 Maybridge1_004958 C/C(=N\Nc1c(Cl)cc(Cl)cc1Cl)/c2ccc(C#CCC3CCCCC3)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J09 compound treatment 691560.0 -157000.0 -0.9 741860.0 -220000.0 -1.1 738490.0 -119748.125 -0.659249344954844 815100.0 -146222.5 -0.872492978451667 -1.7655 -0.9847 2072053 Maybridge1_004959 CCOC(=O)Cn1cc(C#N)c(=O)[nH]c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J10 compound treatment 684280.0 -165000.0 -0.94 752850.0 -209000.0 -1.04 725170.0 -133068.125 -0.732579940108618 815410.0 -145912.5 -0.870643243812196 -1.7946 -0.9921 2072054 Maybridge1_004960 CCCN(C(=O)CC#N)C(=O)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J11 compound treatment 731440.0 -118000.0 -0.67 723780.0 -238000.0 -1.19 771460.0 -86778.125 -0.477739606049444 826360.0 -134962.5 -0.805305842837341 -1.5725 -0.9492 1072028 Maybridge1_004961 OCc1nccn1Cc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J12 compound treatment 675130.0 -174000.0 -0.99 874980.0 -86800.0 -0.43 724080.0 -134158.125 -0.738580717039369 888980.0 -72342.5 -0.431659445664242 -1.2988 -0.9405 1166253 Maybridge1_004962 COC(=O)c1cccc(NC(=O)NCc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J13 compound treatment 793680.0 -55300.0 -0.32 1075240.0 113000.0 0.57 802330.0 -55908.125 -0.30779099701063 1132160.0 170837.5 1.01936787571158 0.4815 0.386 1052980 Maybridge1_004963 OC(=O)CSc1ncccc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J14 compound treatment 793790.0 -55200.0 -0.32 859770.0 -102000.0 -0.51 766750.0 -91488.125 -0.503669568750215 862240.0 -99082.5 -0.591213975533432 -0.9603 -0.9785 2072055 Maybridge1_004964 CCOC(=O)c1cnc2ccc(OC(F)(F)F)cc2c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J15 compound treatment 690990.0 -158000.0 -0.9 741330.0 -220000.0 -1.1 776270.0 -81968.125 -0.451259113355025 745330.0 -215992.5 -1.28880261005127 -1.8727 -0.9489 2072056 Maybridge1_004965 O/N=C/c1ccc(Br)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J16 compound treatment 719840.0 -129000.0 -0.74 728040.0 -234000.0 -1.17 772730.0 -85508.125 -0.470747875130127 820810.0 -140512.5 -0.838422059769802 -1.608 -0.9549 2072057 Maybridge1_004966 Oc1cc(nc2c(Cl)cccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J17 compound treatment 664590.0 -184000.0 -1.05 753480.0 -208000.0 -1.04 736640.0 -121598.125 -0.669434149837312 753310.0 -208012.5 -1.24118686029973 -2.003 -0.9792 2072058 Maybridge1_004967 COc1cc(nc2ccc(C)c([N+](=O)[O-])c12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J18 compound treatment 613870.0 -235000.0 -1.34 726040.0 -236000.0 -1.18 639840.0 -218398.125 -1.20234718368756 860320.0 -101002.5 -0.602670396526283 -2.1636 -0.9673 2072059 Maybridge1_004968 Oc1cc(nc2cc(ccc12)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J19 compound treatment 708250.0 -141000.0 -0.8 765600.0 -196000.0 -0.98 734900.0 -123338.125 -0.679013371726769 822180.0 -139142.5 -0.830247426040527 -1.6473 -0.9916 2072060 Maybridge1_004969 CCOC(=O)C(Cc1cc([N+](=O)[O-])c(Oc2ccc(OC)cc2)c(c1)[N+](=O)[O-])NC(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J20 compound treatment 755360.0 -93700.0 -0.54 734730.0 -227000.0 -1.14 754110.0 -104128.125 -0.57325655994719 874680.0 -86642.5 -0.51698591451725 -1.3804 -0.9367 2072061 Maybridge1_004970 N#CCCOCC1CCN(Cc2ccccc2)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J21 compound treatment 612200.0 -237000.0 -1.35 559240.0 -403000.0 -2.01 571370.0 -286868.125 -1.57929507033763 568160.0 -393162.5 -2.34595579093849 -3.6457 -0.9785 2072062 Maybridge1_004971 O/N=C/c1sccc1Oc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J22 compound treatment 714250.0 -135000.0 -0.77 813610.0 -148000.0 -0.74 781210.0 -77028.125 -0.424062931668866 867900.0 -93422.5 -0.557441401148256 -1.2462 -0.9754 1524000 Maybridge1_004972 N#Cc1nccnc1N2CCN(CC2)C(c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J23 mock treatment 762890.0 -86100.0 -0.49 990080.0 28300.0 0.14 804550.0 -53688.125 -0.295569231151667 900520.0 -60802.5 -0.362801581988459 -0.5044 -0.7271 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 J24 mock treatment 1015590.0 167000.0 0.95 1055330.0 93600.0 0.47 942630.0 84391.875 0.464602584076043 944960.0 -16362.5 -0.0976331710914216 0.8932 0.7688 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K01 compound treatment 868420.0 19400.0 0.11 722800.0 -239000.0 -1.2 983860.0 125621.875 0.691586100456681 942360.0 -18962.5 -0.113147074519241 -0.253 -0.182 2072063 Maybridge1_004973 CSc1sc(Br)c2CCCC(=O)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K02 compound treatment 506450.0 -343000.0 -1.96 549690.0 -412000.0 -2.06 727200.0 -131038.125 -0.721404181237585 653920.0 -307402.5 -1.8342356532578 -3.2868 -0.9503 1446780 Maybridge1_004974 CC1(C)CCc2cc(ccc2O1)c3cc[nH]n3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K03 compound treatment 685700.0 -163000.0 -0.93 678650.0 -283000.0 -1.42 749720.0 -108518.125 -0.597424826668291 773700.0 -187622.5 -1.11952205611002 -2.033 -0.9599 2072064 Maybridge1_004975 CCOC(=O)c1sc(SC)c(c1N)S(=O)(=O)C(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K04 compound treatment 563150.0 -286000.0 -1.63 600530.0 -361000.0 -1.81 608000.0 -250238.125 -1.37763593366475 651750.0 -309572.5 -1.84718379573409 -3.3323 -0.9939 2072065 Maybridge1_004976 CSc1sc(c(c1C#N)c2ccccc2)c3ccnc(SCCS(=O)(=O)C)n3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K05 compound treatment 688690.0 -160000.0 -0.92 797450.0 -164000.0 -0.82 795150.0 -63088.125 -0.347319050554481 891520.0 -69802.5 -0.41650355539245 -1.2508 -0.9301 1506894 Maybridge1_004977 Clc1ccc(cc1)S(=O)(=O)CCN2C(=O)CSC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K06 compound treatment 720530.0 -128000.0 -0.73 775280.0 -186000.0 -0.93 742610.0 -115628.125 -0.636567509216589 845480.0 -115842.5 -0.69121898378353 -1.4972 -0.989 2072066 Maybridge1_004978 OC(=O)c1cccnc1SCCS(=O)(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K07 compound treatment 639630.0 -209000.0 -1.2 673240.0 -289000.0 -1.44 640860.0 -217378.125 -1.19673177775236 737830.0 -223492.5 -1.33355425455459 -2.5847 -0.9968 2072067 Maybridge1_004979 Cc1ccc(cc1)S(=O)(=O)Cc2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K08 compound treatment 673460.0 -176000.0 -1.0 677360.0 -284000.0 -1.42 716160.0 -142078.125 -0.782182692536208 780590.0 -180732.5 -1.0784102120263 -2.143 -0.9777 2072068 Maybridge1_004980 CCOC(=O)c1cnc2n(C)nc(C)c2c1Sc3ccc(cn3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K09 compound treatment 685160.0 -164000.0 -0.94 763680.0 -198000.0 -0.99 764330.0 -93908.125 -0.516992394596471 860250.0 -101072.5 -0.603088078541648 -1.5234 -0.9657 2072069 Maybridge1_004981 Cn1c(S)nnc1CSc2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K10 compound treatment 678610.0 -170000.0 -0.97 654240.0 -308000.0 -1.54 686090.0 -172148.125 -0.947727061625846 749820.0 -211502.5 -1.26201129220861 -2.3606 -0.9799 2072070 Maybridge1_004982 Clc1ccc(Sc2nccnc2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K11 compound treatment 645490.0 -204000.0 -1.16 681340.0 -280000.0 -1.4 653350.0 -204888.125 -1.12797058154586 824870.0 -136452.5 -0.814196502878668 -2.2537 -0.9832 1412588 Maybridge1_004983 NNC(=O)COc1ccccc1CSc2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K12 compound treatment 672200.0 -177000.0 -1.01 668340.0 -293000.0 -1.47 662900.0 -195338.125 -1.07539496715257 692160.0 -269162.5 -1.60606193515018 -2.5796 -0.9813 2072071 Maybridge1_004984 C/C(=N\O)/c1ccc(Cl)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K13 compound treatment 759240.0 -89800.0 -0.51 706330.0 -255000.0 -1.28 820550.0 -37688.125 -0.207484432168155 833280.0 -128042.5 -0.764014992175606 -1.381 -0.8696 2072072 Maybridge1_004985 FC(F)(F)Oc1ccc(cc1)C(=O)/C(=C/Nc2ccccn2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K14 compound treatment 652100.0 -197000.0 -1.12 709670.0 -252000.0 -1.26 683520.0 -174718.125 -0.961875682462573 753610.0 -207712.5 -1.2393967945196 -2.2935 -0.9947 1339863 Maybridge1_004986 NC(=S)C1COc2ccccc2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K15 compound treatment 668370.0 -181000.0 -1.03 689440.0 -272000.0 -1.36 712360.0 -145878.125 -0.803102832294792 746400.0 -214922.5 -1.28241804210213 -2.2398 -0.9813 2072073 Maybridge1_004987 COc1ccc(OC(=O)c2cscc2Sc3ccc(Cl)cc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K16 compound treatment 636730.0 -212000.0 -1.21 620080.0 -342000.0 -1.71 700180.0 -158058.125 -0.870157385520991 759880.0 -201442.5 -1.20198441971482 -2.4969 -0.9724 1083340 Maybridge1_004988 CSc1nc2ccc(cc2s1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K17 compound treatment 645120.0 -204000.0 -1.16 587780.0 -374000.0 -1.87 634210.0 -224028.125 -1.23334202232988 726630.0 -234692.5 -1.40038337701289 -2.8345 -0.9816 1213967 Maybridge1_004989 CCOC(=O)c1cnc2n(C)nc(C)c2c1Oc3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K18 compound treatment 22180.0 -827000.0 -4.72 24160.0 -938000.0 -4.69 23040.0 -835198.125 -4.59801618450196 25760.0 -935562.5 -5.58239472141898 -9.7966 -0.9967 2072074 Maybridge1_004990 [O-][N+](=O)c1ccc(Sc2ccc(F)cc2)c3nonc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K19 compound treatment 524180.0 -325000.0 -1.86 565670.0 -396000.0 -1.98 493050.0 -365188.125 -2.01047016136192 606830.0 -354492.5 -2.11521631187934 -3.9812 -0.9989 2072075 Maybridge1_004991 CCOC(=O)c1sc(SCCS(=O)(=O)c2ccccc2)c3C(=O)CC(C)(C)Cc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K20 compound treatment 713020.0 -136000.0 -0.78 825310.0 -136000.0 -0.68 765120.0 -93118.125 -0.51264320764666 833490.0 -127832.5 -0.762761946129513 -1.3674 -0.9884 2072076 Maybridge1_004992 CNC(=S)NNC(=O)C(CCSC)NC(=O)c1ccc(cc1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K21 compound treatment 708530.0 -140000.0 -0.8 706520.0 -255000.0 -1.28 703550.0 -154688.125 -0.851604524735089 841550.0 -119772.5 -0.714668845503272 -1.8227 -0.9729 1407614 Maybridge1_004993 COC(=O)c1cccc(CN2C(=O)CSC2=O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K22 compound treatment 761700.0 -87300.0 -0.5 804520.0 -157000.0 -0.79 777130.0 -81108.125 -0.446524555409662 831410.0 -129912.5 -0.775173068871768 -1.2535 -0.9707 2072077 Maybridge1_004994 COc1cc(nc2ccc(Br)cc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K23 mock treatment 727210.0 -122000.0 -0.7 850270.0 -111000.0 -0.56 784280.0 -73958.125 -0.407161660863905 890010.0 -71312.5 -0.425513553152452 -1.0431 -0.9761 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 K24 mock treatment 1036170.0 187000.0 1.07 1111780.0 150000.0 0.75 918320.0 60081.875 0.330768742620469 936320.0 -25002.5 -0.149187065559252 1.0005 0.7381 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L01 compound treatment 798240.0 -50800.0 -0.29 1021630.0 59900.0 0.3 965010.0 106771.875 0.587811196654231 808050.0 -153272.5 -0.914559524284792 -0.1587 -0.1363 2072078 Maybridge1_004995 ONC(=O)c1ncc(cc1Cl)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L02 compound treatment 682360.0 -167000.0 -0.95 916190.0 -45600.0 -0.23 757290.0 -100948.125 -0.555749706149217 839790.0 -121532.5 -0.725170564746719 -1.2304 -0.9189 2072079 Maybridge1_004996 COC(=O)c1ccc(Br)o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L03 compound treatment 677300.0 -172000.0 -0.98 943520.0 -18200.0 -0.09 759080.0 -99158.125 -0.545895219262936 844650.0 -116672.5 -0.696171499108564 -1.1571 -0.8739 1442715 Maybridge1_004997 CCOC(=O)NC(=O)c1cn(Cc2ccccn2)c(=O)[nH]c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L04 compound treatment 696610.0 -152000.0 -0.87 777650.0 -184000.0 -0.92 750730.0 -107508.125 -0.591864473732457 861490.0 -99832.5 -0.595689139983764 -1.4895 -0.9798 2072080 Maybridge1_004998 FC(F)(F)c1cccc(c1)n2nc(C#N)c(=O)[nH]c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L05 compound treatment 721620.0 -127000.0 -0.73 792480.0 -169000.0 -0.85 770240.0 -87998.125 -0.484456071971937 884680.0 -76642.5 -0.457317055179482 -1.2581 -0.9677 1505343 Maybridge1_004999 CC(C)n1cc(C#N)c(=O)n(Cc2ccccc2)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L06 compound treatment 182360.0 -667000.0 -3.81 301300.0 -660000.0 -3.3 588580.0 -269658.125 -1.48454885843099 150080.0 -811242.5 -4.84059146213186 -6.7184 -0.9403 2072081 Maybridge1_005000 O=C(Nc1ccccc1)ON=C2CC3CCCC(C2)N3Cc4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L07 compound treatment 667410.0 -182000.0 -1.04 885710.0 -76000.0 -0.38 717280.0 -140958.125 -0.776016756607362 864710.0 -96612.5 -0.576475767277003 -1.3852 -0.9435 1599249 Maybridge1_005001 CCOC(=O)Cn1c(=O)c(C#N)cn(C(C)C)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L08 compound treatment 680900.0 -168000.0 -0.96 842270.0 -119000.0 -0.6 788190.0 -70048.125 -0.385635938112309 943070.0 -18252.5 -0.10891058550626 -1.0263 -0.8552 1037742 Maybridge1_005002 NC(=O)CC(NC(=O)OCc1ccccc1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L09 compound treatment 658500.0 -191000.0 -1.09 793120.0 -169000.0 -0.84 789190.0 -69048.125 -0.380130638175839 871170.0 -90152.5 -0.537929684144806 -1.4249 -0.9335 2072082 Maybridge1_005003 CC(C)(C)c1cc2nc(cc(N/N=C/c3ccc(cc3)C(F)(F)F)n2n1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L10 compound treatment 651400.0 -198000.0 -1.13 729920.0 -232000.0 -1.16 762620.0 -95618.125 -0.526406457487834 863040.0 -98282.5 -0.586440466786411 -1.7007 -0.9448 1727567 Maybridge1_005004 COc1ccc(cc1OC2CCCC2)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L11 compound treatment 643930.0 -205000.0 -1.17 754970.0 -207000.0 -1.03 719250.0 -138988.125 -0.765171315732517 789480.0 -171842.5 -1.02536459607503 -1.9982 -0.9894 2072083 Maybridge1_005005 N#Cc1ccc(C#Cc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L12 compound treatment 711040.0 -138000.0 -0.79 702040.0 -260000.0 -1.3 836450.0 -21788.125 -0.11995016317829 780430.0 -180892.5 -1.07936491377571 -1.6433 -0.8799 1611812 Maybridge1_005006 OC(=O)c1cnc2cc(Cl)cc(Cl)c2c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L13 compound treatment 862790.0 13800.0 0.08 919460.0 -42300.0 -0.21 926750.0 68511.875 0.377178421084907 1019680.0 58357.5 0.348212545880375 0.2962 0.5283 2072084 Maybridge1_005007 Nc1nc(S)ncc1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L14 compound treatment 706810.0 -142000.0 -0.81 724010.0 -238000.0 -1.19 885080.0 26841.875 0.147772572732223 843720.0 -117602.5 -0.701720703026977 -1.2777 -0.7942 2072085 Maybridge1_005008 OC(=O)c1cnc2ccc(OC(F)(F)F)cc2c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L15 compound treatment 745860.0 -103000.0 -0.59 783630.0 -178000.0 -0.89 794400.0 -63838.125 -0.351448025506833 826140.0 -135182.5 -0.806618557742772 -1.3192 -0.9532 1110028 Maybridge1_005009 NC(CC(=O)O)c1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L16 compound treatment 721050.0 -128000.0 -0.73 733400.0 -228000.0 -1.14 734750.0 -123488.125 -0.67983916671724 820590.0 -140732.5 -0.839734774675232 -1.6964 -0.9784 2072086 Maybridge1_005010 CCOc1cc(ccc1OC)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L17 compound treatment 727050.0 -122000.0 -0.7 1039520.0 77800.0 0.39 744090.0 -114148.125 -0.628419665310614 879570.0 -81752.5 -0.487807842301081 -0.712 -0.6319 2072087 Maybridge1_005011 CC(=O)N1CCc2cc(Br)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L18 compound treatment 828730.0 -20300.0 -0.12 849470.0 -112000.0 -0.56 852420.0 -5818.125 -0.0320305231928717 801480.0 -159842.5 -0.953761964869706 -0.8317 -0.747 2072088 Maybridge1_005012 CCCCC#Cc1ccc(o1)C(=O)NNC(=O)Nc2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L19 compound treatment 721720.0 -127000.0 -0.73 908220.0 -53500.0 -0.27 708750.0 -149488.125 -0.822976965065447 923730.0 -37592.5 -0.224310159465501 -1.0211 -0.886 2072089 Maybridge1_005013 OCCSC1CS(=O)(=O)c2cc(ccc12)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L20 compound treatment 654680.0 -194000.0 -1.11 610880.0 -351000.0 -1.75 665350.0 -192888.125 -1.06190698230822 727540.0 -233782.5 -1.39495351081316 -2.661 -0.9791 2072090 Maybridge1_005014 CC(=O)c1cc2c3ccccc3ccc2c4ccccc14 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L21 compound treatment 663330.0 -186000.0 -1.06 732320.0 -229000.0 -1.15 707070.0 -151168.125 -0.832225868958716 812060.0 -149262.5 -0.890632311690348 -1.9656 -0.9918 2072091 Maybridge1_005015 FC(F)(F)Oc1ccc(NC(=O)Nc2cc(n[nH]2)c3ccco3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L22 compound treatment 704650.0 -144000.0 -0.82 748420.0 -213000.0 -1.07 755680.0 -102558.125 -0.564613239046933 881870.0 -79452.5 -0.474084004653395 -1.4652 -0.9533 1173437 Maybridge1_005016 NNC(=O)C1CCN(Cc2cccnc2)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L23 mock treatment 756820.0 -92200.0 -0.53 873520.0 -88200.0 -0.44 824120.0 -34118.125 -0.187830511394959 937570.0 -23752.5 -0.141728458142032 -0.6488 -0.8932 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 L24 mock treatment 803090.0 -45900.0 -0.26 1101510.0 140000.0 0.7 870800.0 12561.875 0.069156889639438 1026940.0 65617.5 0.391532137759594 0.4486 0.5304 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M01 compound treatment 833480.0 -15500.0 -0.09 859080.0 -103000.0 -0.51 950820.0 92581.875 0.509690990555729 1076770.0 115447.5 0.688862063839688 0.2981 0.2972 2072092 Maybridge1_005017 Cc1nn(Cc2nn[nH]n2)c(C)c1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M02 compound treatment 674010.0 -175000.0 -1.0 783250.0 -179000.0 -0.89 722850.0 -135388.125 -0.745352235961227 898810.0 -62512.5 -0.373004956935217 -1.5055 -0.9538 2072093 Maybridge1_005018 CC(C)S(=O)(=O)C/C(=N/OCc1c(Cl)cccc1Cl)/N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M03 compound treatment 667100.0 -182000.0 -1.04 649160.0 -313000.0 -1.56 787640.0 -70598.125 -0.388663853077367 752380.0 -208942.5 -1.24673606421814 -2.1191 -0.9266 2072094 Maybridge1_005019 CC1(C)CC(=CC(=S)S1)N2CCCCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M04 compound treatment 710560.0 -138000.0 -0.79 760870.0 -201000.0 -1.0 750290.0 -107948.125 -0.594286805704503 846080.0 -115242.5 -0.687638852223264 -1.5388 -0.9809 3177265 Maybridge1_005020 CS(=N)c1ncccc1C(F)(F)F.Cc1cc(C)c(c(C)c1)S(=O)(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M05 compound treatment 775810.0 -73200.0 -0.42 737400.0 -224000.0 -1.12 733410.0 -124828.125 -0.687216268632109 946150.0 -15172.5 -0.0905325768302273 -1.1591 -0.8377 1393462 Maybridge1_005021 Cc1ccc(cc1)S(=O)(=O)CCN2C(=O)CSC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M06 compound treatment 743490.0 -106000.0 -0.6 778280.0 -183000.0 -0.92 784480.0 -73758.125 -0.406060600876611 858850.0 -102472.5 -0.611441718848935 -1.269 -0.9609 2072096 Maybridge1_005022 COC(=O)c1ccc(CSc2ccc(cn2)C(F)(F)F)o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M07 compound treatment 653320.0 -196000.0 -1.12 774080.0 -188000.0 -0.94 701890.0 -156348.125 -0.860743322629628 814630.0 -146692.5 -0.875297414840542 -1.8963 -0.9942 1275401 Maybridge1_005023 ONC(=O)CC1Sc2ccccc2NC1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M08 compound treatment 623850.0 -225000.0 -1.29 684430.0 -277000.0 -1.39 659680.0 -198558.125 -1.09312203294801 796240.0 -165082.5 -0.985028447162696 -2.3758 -0.9913 2072097 Maybridge1_005024 [O-][N+](=O)c1cc(ccc1C#N)N2CCSCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M09 compound treatment 24160.0 -825000.0 -4.71 30880.0 -931000.0 -4.66 26690.0 -831548.125 -4.57792183973385 31380.0 -929942.5 -5.54886082247116 -9.7473 -0.9968 2072098 Maybridge1_005025 Fc1c(Cl)cccc1n2sccc2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M10 compound treatment 697730.0 -151000.0 -0.86 719320.0 -242000.0 -1.21 794020.0 -64218.125 -0.353540039482691 818320.0 -143002.5 -0.853279605744906 -1.6418 -0.937 2072099 Maybridge1_005026 Clc1cc(Cl)cc(OS(=O)(=O)c2cccc3nsnc23)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M11 compound treatment 898850.0 49800.0 0.28 734160.0 -228000.0 -1.14 905920.0 47681.875 0.262503023408247 826080.0 -135242.5 -0.806976570898798 -0.6991 -0.4828 1279337 Maybridge1_005027 CCOC(=O)COc1ccccc1CS(=O)(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M12 compound treatment 651120.0 -198000.0 -1.13 816040.0 -146000.0 -0.73 712750.0 -145488.125 -0.800955765319569 980540.0 19217.5 0.114668630432354 -1.2728 -0.8109 1310444 Maybridge1_005028 Clc1cc(c(Cl)s1)S(=O)(=O)Nc2cccc3nsnc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M13 compound treatment 794900.0 -54100.0 -0.31 766590.0 -195000.0 -0.98 824040.0 -34198.125 -0.188270935389877 868050.0 -93272.5 -0.556546368258189 -1.0151 -0.8599 2072100 Maybridge1_005029 FC(F)(F)c1ccc(nc1)S(=O)(=O)CC#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M14 compound treatment 720340.0 -129000.0 -0.74 827050.0 -135000.0 -0.67 770420.0 -87818.125 -0.483465117983372 886340.0 -74982.5 -0.447412024529413 -1.1699 -0.9789 2072101 Maybridge1_005030 OC(=O)CSCCOc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M15 compound treatment 675060.0 -174000.0 -0.99 727240.0 -235000.0 -1.17 700290.0 -157948.125 -0.869551802527979 837530.0 -123792.5 -0.738655726957055 -1.8875 -0.9859 1360550 Maybridge1_005031 COC(=O)c1ccc2C(=O)CS(=O)(=O)N(C)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M16 compound treatment 881440.0 32400.0 0.19 972020.0 10300.0 0.05 782110.0 -76128.125 -0.419108161726043 919460.0 -41862.5 -0.249788762402728 -0.2162 -0.4123 2072102 Maybridge1_005032 NC(=S)c1ccc2nonc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M17 compound treatment 775410.0 -73600.0 -0.42 837440.0 -124000.0 -0.62 792340.0 -65898.125 -0.36278894337596 857280.0 -104042.5 -0.620809729764965 -1.0129 -0.9745 1983576 Maybridge1_005033 CN(c1ccccc1)S(=O)(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M18 compound treatment 592400.0 -257000.0 -1.47 640340.0 -321000.0 -1.61 626560.0 -231678.125 -1.27545756684388 681150.0 -280172.5 -1.67175734928106 -3.0104 -0.9949 2072103 Maybridge1_005034 Clc1ccc(cc1)S(=O)(=O)NCc2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M19 compound treatment 420230.0 -429000.0 -2.45 374210.0 -588000.0 -2.94 416290.0 -441948.125 -2.43305698448532 371040.0 -590282.5 -3.52214834620456 -5.6717 -0.9879 2072104 Maybridge1_005035 CSc1sc(C(=O)N)c2CCc3conc3-c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M20 compound treatment 508880.0 -340000.0 -1.94 564220.0 -398000.0 -1.99 574040.0 -284198.125 -1.56459591950726 625470.0 -335852.5 -2.00399355807375 -3.75 -0.9954 2072105 Maybridge1_005036 FC(F)(F)c1cccc(c1)S(=O)(=O)NCC2COc3ccccc3O2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M21 compound treatment 657760.0 -191000.0 -1.09 723400.0 -238000.0 -1.19 735680.0 -122558.125 -0.674719237776323 813510.0 -147812.5 -0.881980327086372 -1.9207 -0.9791 2072106 Maybridge1_005037 COC(=O)CSCCC(=S)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M22 compound treatment 693470.0 -156000.0 -0.89 709150.0 -253000.0 -1.26 755610.0 -102628.125 -0.564998610042486 891630.0 -69692.5 -0.415847197939734 -1.5664 -0.9234 2072107 Maybridge1_005038 COC(=O)c1scc2c(O)cc(nc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M23 mock treatment 796130.0 -52900.0 -0.3 900450.0 -61300.0 -0.31 864390.0 6151.875 0.0338679170466684 840290.0 -121032.5 -0.722187121779831 -0.6486 -0.7708 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 M24 mock treatment 734560.0 -114000.0 -0.65 978290.0 16500.0 0.08 757940.0 -100298.125 -0.552171261190512 1002720.0 41397.5 0.247014160443522 -0.4382 -0.4898 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N01 compound treatment 762660.0 -86400.0 -0.49 749450.0 -212000.0 -1.06 734310.0 -123928.125 -0.682261498689286 776420.0 -184902.5 -1.10329212637015 -1.6704 -0.9559 1088056 Maybridge1_005039 Oc1cc(nc2ccccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N02 compound treatment 668230.0 -181000.0 -1.03 784030.0 -178000.0 -0.89 736450.0 -121788.125 -0.670480156825241 770240.0 -191082.5 -1.14016748144089 -1.8662 -0.9827 2072108 Maybridge1_005040 COC(=O)c1ccc(C#Cc2ccccc2)o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N03 compound treatment 701490.0 -148000.0 -0.84 772170.0 -190000.0 -0.95 766960.0 -91278.125 -0.502513455763557 857290.0 -104032.5 -0.620750060905627 -1.4571 -0.972 2072109 Maybridge1_005041 O=c1[nH]c(=O)n(cc1C#N)C2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N04 compound treatment 787770.0 -61300.0 -0.35 884800.0 -77000.0 -0.38 883230.0 24991.875 0.137587767849754 884650.0 -76672.5 -0.457496061757496 -0.5274 -0.7467 2072110 Maybridge1_005042 CCOC(=O)c1c(O)c2cccc(c2nc1SC)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N05 compound treatment 697390.0 -152000.0 -0.87 781680.0 -180000.0 -0.9 746610.0 -111628.125 -0.614546309470711 923640.0 -37682.5 -0.224847179199541 -1.3031 -0.9238 2072111 Maybridge1_005043 CSc1nn(cc1/C(=N/O)/N)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N06 compound treatment 729320.0 -120000.0 -0.68 780320.0 -181000.0 -0.91 763150.0 -95088.125 -0.523488648521505 880200.0 -81122.5 -0.484048704162802 -1.2994 -0.9687 2072112 Maybridge1_005044 NC(Cc1csc2ccc(Cl)cc12)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N07 compound treatment 812340.0 -36700.0 -0.21 969550.0 7800.0 0.04 777780.0 -80458.125 -0.442946110450956 912030.0 -49292.5 -0.294122724890689 -0.4538 -0.7922 2072113 Maybridge1_005045 COC(=O)c1sccc1Oc2nccnc2C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N08 compound treatment 632610.0 -216000.0 -1.24 639520.0 -322000.0 -1.61 709450.0 -148788.125 -0.819123255109918 743010.0 -218312.5 -1.30264578541763 -2.4849 -0.9751 2072114 Maybridge1_005046 CC(=O)c1ccc(C#CCO)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N09 compound treatment 728920.0 -120000.0 -0.69 789760.0 -172000.0 -0.86 769360.0 -88878.125 -0.48930073591603 840360.0 -120962.5 -0.721769439764467 -1.3787 -0.982 2072115 Maybridge1_005047 OCc1nccn1Cc2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N10 compound treatment 462520.0 -387000.0 -2.21 499610.0 -462000.0 -2.31 546300.0 -311938.125 -1.71731293974492 554690.0 -406632.5 -2.42632974446646 -4.3315 -0.9923 1913810 Maybridge1_005048 [O-][N+](=O)c1ccc(/C=N/Nc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N11 compound treatment 729770.0 -119000.0 -0.68 741520.0 -220000.0 -1.1 703520.0 -154718.125 -0.851769683733183 820860.0 -140462.5 -0.838123715473113 -1.7363 -0.9853 1043306 Maybridge1_005049 Cc1c(Cl)cc(cc1Cl)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N12 compound treatment 681450.0 -168000.0 -0.96 801890.0 -160000.0 -0.8 787490.0 -70748.125 -0.389489648067837 843950.0 -117372.5 -0.700348319262208 -1.4233 -0.9601 1455622 Maybridge1_005050 Oc1ccnc2cc(Cl)cc(Cl)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N13 compound treatment 750750.0 -98300.0 -0.56 857760.0 -104000.0 -0.52 822420.0 -35818.125 -0.197189521286957 986810.0 25487.5 0.152081005237134 -0.5633 -0.6999 1334136 Maybridge1_005051 Cn1c(=O)c(C#N)cn(c2ccccc2)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N14 compound treatment 734150.0 -115000.0 -0.66 801600.0 -160000.0 -0.8 798630.0 -59608.125 -0.328160606775567 919360.0 -41962.5 -0.250385450996106 -1.0179 -0.9131 2072116 Maybridge1_005052 N/C(=N\O)/CCN(Cc1ccco1)S(=O)(=O)c2cccc3nsnc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N15 compound treatment 754030.0 -95000.0 -0.54 891750.0 -70000.0 -0.35 774130.0 -84108.125 -0.46304045521907 816120.0 -145202.5 -0.866406754799214 -1.1111 -0.9451 2072117 Maybridge1_005053 COC(=O)C(C#N)c1ccccc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N16 compound treatment 713250.0 -136000.0 -0.78 763000.0 -199000.0 -0.99 765670.0 -92568.125 -0.509615292681602 848360.0 -112962.5 -0.674034352294253 -1.4767 -0.9729 2072118 Maybridge1_005054 Oc1cc(nc2c(F)cccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N17 compound treatment 579870.0 -269000.0 -1.54 638090.0 -324000.0 -1.62 605400.0 -252838.125 -1.39194971349957 617840.0 -343482.5 -2.04952089774846 -3.2989 -0.9892 1382524 Maybridge1_005055 CCOC(=O)c1cncc(C#Cc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N18 compound treatment 724410.0 -125000.0 -0.71 726410.0 -235000.0 -1.18 795900.0 -62338.125 -0.343190075602129 799320.0 -162002.5 -0.966650438486663 -1.5994 -0.9321 2072119 Maybridge1_005056 CCCCC#Cc1ccc(o1)C(=O)NNC(=O)Nc2cc(Cl)cc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N19 compound treatment 760250.0 -88800.0 -0.51 803520.0 -158000.0 -0.79 784040.0 -74198.125 -0.408482932848657 850840.0 -110482.5 -0.659236475178487 -1.1831 -0.9709 1473501 Maybridge1_005057 CC(=O)NC(Cc1ccc(OC(=O)C)cc1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N20 compound treatment 759650.0 -89400.0 -0.51 787550.0 -174000.0 -0.87 786930.0 -71308.125 -0.39257261603226 891680.0 -69642.5 -0.415548853643045 -1.095 -0.9436 2072120 Maybridge1_005058 CN(C)S(=O)(=O)Nc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N21 compound treatment 688920.0 -160000.0 -0.91 826080.0 -136000.0 -0.68 770640.0 -87598.125 -0.482253951997349 994840.0 33517.5 0.199995099285361 -0.9377 -0.7485 2072121 Maybridge1_005059 N/C(=N\O)/CS(=O)(=O)c1ccc(F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N22 compound treatment 861560.0 12500.0 0.07 773250.0 -189000.0 -0.94 733920.0 -124318.125 -0.684408565664509 823110.0 -138212.5 -0.824698222122115 -1.1902 -0.8328 2072122 Maybridge1_005060 COc1ccc(CNC(=O)Nc2ccccc2C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N23 mock treatment 794100.0 -54900.0 -0.31 977940.0 16200.0 0.08 908510.0 50271.875 0.276761750243703 922970.0 -38352.5 -0.228844992775172 -0.0924 -0.1911 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 N24 mock treatment 800320.0 -48700.0 -0.28 1031680.0 69900.0 0.35 780160.0 -78078.125 -0.429843496602159 920910.0 -40412.5 -0.241136777798752 -0.2997 -0.4505 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O01 compound treatment 702120.0 -147000.0 -0.84 851600.0 -110000.0 -0.55 981620.0 123381.875 0.67925422859899 1028270.0 66947.5 0.399468096051517 -0.1557 -0.122 1299316 Maybridge1_005061 NS(=O)(=O)c1ccc(Sc2ccccc2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O02 compound treatment 24370.0 -825000.0 -4.71 32260.0 -929000.0 -4.65 29280.0 -828958.125 -4.56366311289839 36340.0 -924982.5 -5.51926506823963 -9.7213 -0.9969 2072123 Maybridge1_005062 [O-][N+](=O)c1ccsc1Oc2ccc(C#N)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O03 compound treatment 754640.0 -94400.0 -0.54 866490.0 -95300.0 -0.48 830320.0 -27918.125 -0.153697651788848 1085220.0 123897.5 0.739282249980101 -0.215 -0.2062 2072124 Maybridge1_005063 CSC1=CC(=O)CC(C)(C)S1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O04 compound treatment 736650.0 -112000.0 -0.64 847480.0 -114000.0 -0.57 820590.0 -37648.125 -0.207264220170696 758840.0 -202482.5 -1.20818998108594 -1.3145 -0.878 1317959 Maybridge1_005064 O=C1NC2(CCCCC2)NC3=C1CCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O05 compound treatment 726200.0 -123000.0 -0.7 728160.0 -234000.0 -1.17 911100.0 52861.875 0.29102047707916 878290.0 -83032.5 -0.495445456296316 -1.0372 -0.7013 2072125 Maybridge1_005065 CN(C)/C=C/C(=O)c1sc2sc(Br)c(C)c2c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O06 compound treatment 732860.0 -116000.0 -0.66 776260.0 -185000.0 -0.93 959550.0 101311.875 0.557752259001108 863730.0 -97592.5 -0.582323315492105 -0.808 -0.5784 2072126 Maybridge1_005066 CCOC(=O)c1c[nH]c(S)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O07 compound treatment 273050.0 -576000.0 -3.29 256480.0 -705000.0 -3.53 333720.0 -524518.125 -2.88762960023961 196410.0 -764912.5 -4.56414563681999 -7.1348 -0.9853 2072127 Maybridge1_005067 CC(C)(C)c1cc(ccc1/C=N/O)c2nccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O08 compound treatment 673460.0 -176000.0 -1.0 614150.0 -348000.0 -1.74 717960.0 -140278.125 -0.772273152650563 785120.0 -176202.5 -1.05138021874629 -2.2826 -0.9535 2072128 Maybridge1_005068 N#Cc1nccnc1Sc2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O09 compound treatment 650980.0 -198000.0 -1.13 732320.0 -229000.0 -1.15 853250.0 -4988.125 -0.027461124245602 722880.0 -238442.5 -1.42275919926456 -1.8645 -0.8673 2072129 Maybridge1_005069 CSc1nccc(n1)c2ccsc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O10 compound treatment 727680.0 -121000.0 -0.69 883100.0 -78700.0 -0.39 886250.0 28011.875 0.154213773657892 841850.0 -119472.5 -0.712878779723139 -0.8226 -0.7614 2072130 Maybridge1_005070 CCOC(=O)CNS(=O)(=O)c1cccc2nsnc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O11 compound treatment 834660.0 -14400.0 -0.08 936480.0 -25300.0 -0.13 796380.0 -61858.125 -0.340547531632623 891650.0 -69672.5 -0.415727860221059 -0.4824 -0.8643 2072131 Maybridge1_005071 CN1c2sc(C)c(C)c2C(=C(C(=O)Nc3ccc(OC(F)(F)F)cc3)S1(=O)=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O12 compound treatment 733940.0 -115000.0 -0.66 933150.0 -28600.0 -0.14 981370.0 123131.875 0.677877903614872 813920.0 -147402.5 -0.879533903853523 -0.5011 -0.3859 1180269 Maybridge1_005072 CSc1ccc(Oc2cccc(F)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O13 compound treatment 721150.0 -128000.0 -0.73 786490.0 -175000.0 -0.88 969120.0 110881.875 0.610437979393121 785980.0 -175342.5 -1.04624869684324 -1.0215 -0.6138 1344419 Maybridge1_005073 CCCS(=O)(=O)c1cc2ccccc2oc1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O14 compound treatment 809680.0 -39300.0 -0.22 784220.0 -178000.0 -0.89 799170.0 -59068.125 -0.325187744809873 818970.0 -142352.5 -0.849401129887951 -1.1437 -0.886 2072132 Maybridge1_005074 COc1ccc(cc1OC)/C(=N/O)/C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O15 compound treatment 696960.0 -152000.0 -0.87 744510.0 -217000.0 -1.09 1105920.0 247681.875 1.36356301070215 852410.0 -108912.5 -0.649868464262457 -0.6208 -0.3023 2072133 Maybridge1_005075 CSc1nc(nc(C2CC2)c1C#N)c3cnccn3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O16 compound treatment 720090.0 -129000.0 -0.74 958210.0 -3540.0 -0.02 890560.0 32321.875 0.177941616384076 893660.0 -67662.5 -0.403734419494167 -0.49 -0.5706 1476668 Maybridge1_005076 CCOC(=O)CC1Sc2ccccc2NC1=S 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O17 compound treatment 733350.0 -116000.0 -0.66 743790.0 -218000.0 -1.09 813200.0 -45038.125 -0.247948386701206 898120.0 -63202.5 -0.377122108229523 -1.188 -0.8785 2072134 Maybridge1_005077 CS(=O)(=O)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O18 compound treatment 24200.0 -825000.0 -4.71 29460.0 -932000.0 -4.66 24730.0 -833508.125 -4.58871222760933 29160.0 -932162.5 -5.56210730924414 -9.7628 -0.9967 2072135 Maybridge1_005078 [O-][N+](=O)c1ccc(SCCOC(=O)Nc2ccccc2)c3nonc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O19 compound treatment 624430.0 -225000.0 -1.28 615940.0 -346000.0 -1.73 665310.0 -192928.125 -1.06212719430568 665350.0 -295972.5 -1.76603414703473 -2.9204 -0.9798 2072136 Maybridge1_005079 CC(=O)c1sc(SCCS(=O)(=O)c2ccccc2)c3C(=O)CC(C)(C)Cc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O20 compound treatment 610410.0 -239000.0 -1.36 797410.0 -164000.0 -0.82 764180.0 -94058.125 -0.517818189586942 874370.0 -86952.5 -0.51883564915672 -1.6109 -0.9192 1004503 Maybridge1_005080 CCOC(=O)N(c1ccccc1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O21 compound treatment 677620.0 -171000.0 -0.98 757300.0 -204000.0 -1.02 887120.0 28881.875 0.159003384602621 854480.0 -106842.5 -0.637517010379539 -1.2401 -0.7945 1983526 Maybridge1_005081 CC(=O)N1CCc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O22 compound treatment 738290.0 -111000.0 -0.63 835860.0 -126000.0 -0.63 729050.0 -129188.125 -0.711219376355116 1067880.0 106557.5 0.635816447888413 -0.6688 -0.512 2072137 Maybridge1_005082 COc1cc(nc2cc(nn12)C(C)(C)C)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O23 mock treatment 937210.0 88200.0 0.5 1057710.0 96000.0 0.48 954010.0 95771.875 0.527252897353066 1027550.0 66227.5 0.395171938179198 0.953 0.9946 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 O24 mock treatment 946200.0 97200.0 0.56 997510.0 35800.0 0.18 915230.0 56991.875 0.313757365816779 1065000.0 103677.5 0.618631816399136 0.8332 0.9194 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P01 compound treatment 756650.0 -92400.0 -0.53 902530.0 -59200.0 -0.3 869760.0 11521.875 0.0634313777055097 922630.0 -38692.5 -0.230873733992656 -0.4957 -0.7616 2072138 Maybridge1_005083 COC(=O)CSc1cc(nc2ccccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P02 compound treatment 848580.0 -448.0 0.0 914620.0 -47100.0 -0.24 880590.0 22351.875 0.123053776017475 990740.0 29417.5 0.175530866956877 0.0301 0.0946 1423734 Maybridge1_005084 NNC(=O)Cc1nc(no1)c2cnccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P03 compound treatment 764770.0 -84300.0 -0.48 823580.0 -138000.0 -0.69 919900.0 61661.875 0.339467116520091 1062020.0 100697.5 0.600850496316481 -0.116 -0.1066 1704264 Maybridge1_005085 Fc1ccc(c(F)c1)n2cc(C#N)c(=O)[nH]c2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P04 compound treatment 927410.0 78400.0 0.45 1056480.0 94700.0 0.47 1047390.0 189151.875 1.04133780542059 1012080.0 50757.5 0.302864212783672 1.1329 0.8953 1652651 Maybridge1_005086 N#CC1CN(C1)C(c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P05 compound treatment 770170.0 -78900.0 -0.45 1003360.0 41600.0 0.21 1021510.0 163271.875 0.898860643064759 1110240.0 148917.5 0.888573736043195 0.7725 0.5689 1427912 Maybridge1_005087 COc1ccc(cc1OC)C2=NC(C)(C)CO2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P06 compound treatment 766680.0 -82300.0 -0.47 946290.0 -15500.0 -0.08 1010630.0 152391.875 0.83896297975597 1005380.0 44057.5 0.262886077027368 0.2771 0.277 2072139 Maybridge1_005088 COC(=O)c1ccc(cc1Cl)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P07 compound treatment 765820.0 -83200.0 -0.48 792890.0 -169000.0 -0.84 1040270.0 182031.875 1.00214006987293 1154950.0 193627.5 1.15535320614235 0.4188 0.2313 1433980 Maybridge1_005089 CC(C)n1cc(c2nc(C)cs2)c(=O)n(CC(=O)NN)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P08 compound treatment 872660.0 23600.0 0.13 898490.0 -63300.0 -0.32 933930.0 75691.875 0.416706474628759 970920.0 9597.5 0.0572671877494221 0.1463 0.2692 2072140 Maybridge1_005090 Cc1ccc2nc(cc(N3CCNCC3)c2c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P09 compound treatment 923170.0 74100.0 0.42 1050490.0 88700.0 0.44 958920.0 100681.875 0.554283920041132 1097650.0 136327.5 0.813450642136946 1.1175 0.9635 2072141 Maybridge1_005091 Cc1[nH]c2ccccc2c1SCc3nnc(SCC(=O)Nc4cccc(c4)C(F)(F)F)n3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P10 compound treatment 842240.0 -6790.0 -0.04 972760.0 11000.0 0.06 914030.0 55791.875 0.307151005893015 859790.0 -101532.5 -0.605832846071185 -0.1412 -0.2069 2072142 Maybridge1_005092 C/C(=N\O)/c1cccc(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P11 compound treatment 848320.0 -708.0 0.0 969210.0 7460.0 0.04 895490.0 37251.875 0.20508274507087 921930.0 -39392.5 -0.2350505541463 0.0016 0.0052 2072143 Maybridge1_005093 CCOC(=O)c1ccc(OCC#C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P12 compound treatment 625820.0 -223000.0 -1.28 795680.0 -166000.0 -0.83 740980.0 -117258.125 -0.645541148113035 849330.0 -111992.5 -0.668246472938489 -1.7097 -0.9589 2072144 Maybridge1_005094 CCOC(=O)c1cc2cc(OC(F)(F)F)ccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P13 compound treatment 978810.0 130000.0 0.74 995880.0 34100.0 0.17 1046640.0 188401.875 1.03720883046824 1117520.0 156197.5 0.932012665641089 1.4406 0.9069 2072145 Maybridge1_005095 O=S1(=O)CC(Sc2cccs2)c3ccccc31 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P14 compound treatment 745060.0 -104000.0 -0.59 905220.0 -56500.0 -0.28 1038960.0 180721.875 0.994928126956152 1071960.0 110637.5 0.660161342498222 0.3892 0.2855 1077343 Maybridge1_005096 OC1(CN2CCC1CC2)C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P15 compound treatment 936510.0 87500.0 0.5 819440.0 -142000.0 -0.71 975920.0 117681.875 0.647874018961114 870130.0 -91192.5 -0.544135245515934 -0.0542 -0.0446 2072146 Maybridge1_005097 CN(CCO)c1cc(nc2ccccc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P16 compound treatment 845640.0 -3390.0 -0.02 1022080.0 60300.0 0.3 976540.0 118301.875 0.651287304921725 950400.0 -10922.5 -0.0651733116116762 0.4342 0.6023 2072147 Maybridge1_005098 Oc1cc(nc2ccc(OC(F)(F)F)cc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P17 compound treatment 882350.0 33300.0 0.19 918430.0 -43300.0 -0.22 1009730.0 151491.875 0.834008209813148 904800.0 -56522.5 -0.337263310191895 0.2352 0.249 1415776 Maybridge1_005099 CCOC(=O)c1cncc(C#CCO)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P18 compound treatment 931150.0 82100.0 0.47 998360.0 36600.0 0.18 754000.0 -104238.125 -0.573862142940201 914310.0 -47012.5 -0.280518224961678 -0.1011 -0.1243 2072148 Maybridge1_005100 CCCCC#Cc1ccc(o1)C(=O)NNC(=O)Nc2ccc(OC(F)(F)F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P19 compound treatment 971840.0 123000.0 0.7 1057220.0 95500.0 0.48 901520.0 43281.875 0.238279703687782 1135360.0 174037.5 1.03846191069967 1.2279 0.9015 1007764 Maybridge1_005101 [O-][N+](=O)c1ccc2COC(=O)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P20 compound treatment 826470.0 -22600.0 -0.13 914850.0 -46900.0 -0.23 917620.0 59381.875 0.326915032664941 1008010.0 46687.5 0.278578987033201 0.121 0.2391 2072149 Maybridge1_005102 Fc1ccccc1CN(C(=O)CC#N)C(=O)NC2CCCCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P21 compound treatment 964800.0 116000.0 0.66 1026030.0 64300.0 0.32 946690.0 88451.875 0.48695410181811 1102350.0 141027.5 0.841495006025697 1.1556 0.948 1716936 Maybridge1_005103 O=C(C1COc2ccccc2O1)N3CCNCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P22 compound treatment 925940.0 76900.0 0.44 966490.0 4740.0 0.02 952080.0 93841.875 0.51662766847568 1114760.0 153437.5 0.915544060463866 0.9476 0.8315 1136589 Maybridge1_005104 CCCOc1cc(ccc1OC)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P23 mock treatment 852190.0 3160.0 0.02 987920.0 26200.0 0.13 898200.0 39961.875 0.220002107898703 1118880.0 157557.5 0.940127630511026 0.6545 0.6716 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.555 P24 mock treatment 830370.0 -18700.0 -0.11 914520.0 -47200.0 -0.24 967620.0 109381.875 0.602180029488417 1041010.0 79687.5 0.475486222847832 0.3674 0.4537 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A01 compound treatment 861880.0 -16900.0 -0.1 957200.0 26700.0 0.13 871110.0 1962.1875 0.0108024307190913 1024260.0 55734.375 0.332560658215337 0.1902 0.512 1229519 Maybridge1_005105 COc1ccc(cc1OC(C)C)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A02 compound treatment 906460.0 27600.0 0.16 943960.0 13500.0 0.07 908160.0 39012.1875 0.214773793365287 1063940.0 95414.375 0.569326692067597 0.5048 0.7983 2072150 Maybridge1_005106 O=C(NCc1ccccc1)c2ccc3nonc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A03 compound treatment 879890.0 1070.0 0.01 989160.0 58700.0 0.29 953280.0 84132.1875 0.463172926498791 1052210.0 83684.375 0.499335120064396 0.6311 0.8509 2072151 Maybridge1_005107 CC(=O)Nc1ccc(Br)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A04 compound treatment 919270.0 40400.0 0.23 940320.0 9860.0 0.05 941770.0 72622.1875 0.399806924230027 1028200.0 59674.375 0.356070188794417 0.5181 0.8854 1323461 Maybridge1_005108 COc1ccc(Cl)cc1NC(=O)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A05 compound treatment 921620.0 42800.0 0.24 985050.0 54600.0 0.27 916280.0 47132.1875 0.259476828849419 1104020.0 135494.375 0.808479480293368 0.7927 0.8572 2072152 Maybridge1_005109 CCCCNC(=O)NCCSCc1ccco1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A06 compound treatment 790660.0 -88200.0 -0.5 864080.0 -66400.0 -0.33 841130.0 -28017.8125 -0.154246461376265 900800.0 -67725.625 -0.404111079168737 -0.697 -0.939 1296767 Maybridge1_005110 Clc1ccc(NC(=O)NC2Cc3ccccc3C2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A07 compound treatment 590250.0 -289000.0 -1.65 634040.0 -296000.0 -1.48 665920.0 -203227.8125 -1.11883006324509 716270.0 -252255.625 -1.50518054052856 -2.8775 -0.9909 2072153 Maybridge1_005111 Clc1cc(Cl)cc(NC(=O)NCCSCc2ccco2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A08 compound treatment 938950.0 60100.0 0.34 949630.0 19200.0 0.1 936160.0 67012.1875 0.368922191586433 1023310.0 54784.375 0.326892116578249 0.5676 0.933 2072154 Maybridge1_005112 Cn1c(SCc2ccc(OC(F)(F)F)cc2)nnc1c3ccc4ncccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A09 compound treatment 919050.0 40200.0 0.23 963800.0 33300.0 0.17 984500.0 115352.1875 0.63504839051537 1122720.0 154194.375 0.920060247254993 0.9758 0.846 2072155 Maybridge1_005113 Cc1ccc(cc1)S(=O)(=O)NC(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A10 compound treatment 890240.0 11400.0 0.07 941450.0 11000.0 0.05 954580.0 85432.1875 0.470329816416202 1079440.0 110914.375 0.661813424041136 0.6262 0.767 1151309 Maybridge1_005114 O=C(NC1Cc2ccccc2C1)C3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A11 compound treatment 892990.0 14200.0 0.08 900750.0 -29700.0 -0.15 859740.0 -9407.8125 -0.0517928295585671 1048190.0 79664.375 0.475348238610614 0.178 0.3508 2072156 Maybridge1_005115 O=C(NCCSCc1ccco1)C2CCCCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A12 compound treatment 711360.0 -167000.0 -0.96 660320.0 -270000.0 -1.35 591040.0 -278107.8125 -1.53106692248793 732220.0 -236305.625 -1.41000870988482 -2.6244 -0.9868 1589902 Maybridge1_005116 Brc1ccc(s1)S(=O)(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A13 compound treatment 738400.0 -140000.0 -0.8 699630.0 -231000.0 -1.15 703270.0 -165877.8125 -0.913207110617952 770940.0 -197585.625 -1.17897088652898 -2.0244 -0.9878 1661456 Maybridge1_005117 Clc1ccc(NC(=O)c2ccc3snnc3c2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A14 compound treatment 938940.0 60100.0 0.34 1006820.0 76400.0 0.38 932000.0 62852.1875 0.34602014385072 962080.0 -6445.625 -0.0384603091468996 0.5165 0.8323 2072157 Maybridge1_005118 CC(C)(C)c1cc2nc(cc(n2n1)C(F)(F)F)c3ccc4OCOc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A15 compound treatment 829230.0 -49600.0 -0.28 863150.0 -67300.0 -0.34 797650.0 -71497.8125 -0.393616902613959 919050.0 -49475.625 -0.295215410877312 -0.6544 -0.9914 2072158 Maybridge1_005119 COc1ccc(cc1OC)c2cc([nH]n2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A16 compound treatment 935490.0 56700.0 0.32 963580.0 33100.0 0.17 962190.0 93042.1875 0.512225148932735 1038490.0 69964.375 0.41746944505298 0.7095 0.9407 1539036 Maybridge1_005120 O=C(CSc1nc2ccccc2o1)NC3Cc4ccccc4C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A17 compound treatment 957560.0 78700.0 0.45 997290.0 66800.0 0.33 938720.0 69572.1875 0.383015759423795 1040500.0 71974.375 0.429462885779871 0.7983 0.9938 2072159 Maybridge1_005121 Cc1cc2nc(cc(n2n1)C(F)(F)F)c3ccc4OCOc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A18 compound treatment 987950.0 109000.0 0.62 994320.0 63900.0 0.32 976180.0 107032.1875 0.589244295043943 1044410.0 75884.375 0.452793409780938 0.9924 0.9718 1365169 Maybridge1_005122 CC(C)(C)OC(=O)NCc1nnc(S)n1c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A19 compound treatment 966000.0 87200.0 0.5 979170.0 48700.0 0.24 798090.0 -71057.8125 -0.391194570641913 1045820.0 77294.375 0.461206718947563 0.4058 0.4946 2072160 Maybridge1_005123 Fc1cccc(Cl)c1CSCC(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A20 compound treatment 989530.0 111000.0 0.63 1021390.0 90900.0 0.45 924760.0 55612.1875 0.306161772310681 1077920.0 109394.375 0.652743757421796 1.0231 0.9639 2072161 Maybridge1_005124 Fc1cccc2c(cc(nc12)C(F)(F)F)N3CCN(CCOC(=O)C(F)(F)F)CC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A21 compound treatment 929600.0 50800.0 0.29 991200.0 60700.0 0.3 920860.0 51712.1875 0.28469110255845 1022190.0 53664.375 0.320209204332419 0.5994 0.9989 2072162 Maybridge1_005125 FC(F)(F)c1cc(nc2cc(nn12)C3CC3)c4ccc(Cl)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A22 compound treatment 939140.0 60300.0 0.34 953350.0 22900.0 0.11 907200.0 38052.1875 0.209488705426276 1055610.0 87084.375 0.519622532239237 0.5941 0.8898 2072163 Maybridge1_005126 CCOC(=O)c1ccc2nc(cc(N3CCCCC3)c2c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A23 mock treatment 934180.0 55400.0 0.32 946720.0 16300.0 0.08 969890.0 100742.1875 0.55461595844355 1064640.0 96114.375 0.573503512221241 0.7628 0.8849 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 A24 mock treatment 929320.0 50500.0 0.29 881630.0 -48800.0 -0.24 914400.0 45252.1875 0.249126864968857 1051930.0 83404.375 0.497664392002939 0.3955 0.5879 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B01 compound treatment 987890.0 109000.0 0.62 891140.0 -39300.0 -0.2 912020.0 42872.1875 0.236024251120059 1032770.0 64244.375 0.383338857511777 0.5229 0.659 2072164 Maybridge1_005127 CSc1nc2ccc(NC(=O)c3ccccc3C(F)(F)F)cc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B02 compound treatment 816850.0 -62000.0 -0.35 970500.0 40000.0 0.2 811220.0 -57927.8125 -0.318909982476068 989830.0 21304.375 0.127120775515404 -0.1728 -0.3246 2072165 Maybridge1_005128 CCOC(=O)NNC(=S)Nc1ccccc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B03 compound treatment 803800.0 -75000.0 -0.43 859240.0 -71200.0 -0.36 843950.0 -25197.8125 -0.138721515555421 929890.0 -38635.625 -0.230534367355172 -0.577 -0.9324 2072166 Maybridge1_005129 Cc1ccc(cc1Cl)c2ccc(C)c(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B04 compound treatment 467710.0 -411000.0 -2.35 514480.0 -416000.0 -2.08 341330.0 -527817.8125 -2.90579536962373 504160.0 -464365.625 -2.77081671594194 -5.0528 -0.9916 2072167 Maybridge1_005130 FC(F)(F)c1cccc(NNC(=S)Nc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B05 compound treatment 782210.0 -96600.0 -0.55 773230.0 -157000.0 -0.79 752800.0 -116347.8125 -0.640529604764617 930410.0 -38115.625 -0.227431586669608 -1.1031 -0.9373 1020737 Maybridge1_005131 COc1cc(Br)c(OC)cc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B06 compound treatment 855470.0 -23400.0 -0.13 820340.0 -110000.0 -0.55 813810.0 -55337.8125 -0.304651255640612 888570.0 -79955.625 -0.477086094138826 -0.7329 -0.9151 2072168 Maybridge1_005132 CCOC(=O)N/N=C/c1cc(OC)c(OC)c(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B07 compound treatment 713070.0 -166000.0 -0.95 705040.0 -225000.0 -1.13 685360.0 -183787.8125 -1.01180703248012 804090.0 -164435.625 -0.981168617824284 -2.0336 -0.9978 2072169 Maybridge1_005133 CCSc1nc2ccccc2nc1SCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B08 compound treatment 772270.0 -107000.0 -0.61 808910.0 -122000.0 -0.61 763220.0 -105927.8125 -0.583164379426605 852190.0 -116335.625 -0.694161404409623 -1.247 -0.9977 2072170 Maybridge1_005134 COc1ccccc1NC(=S)NNC(=O)NNC(=S)Nc2ccccc2OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B09 compound treatment 691690.0 -187000.0 -1.07 694200.0 -236000.0 -1.18 710130.0 -159017.8125 -0.875440753053771 786510.0 -182015.625 -1.08606647254008 -2.1061 -0.9945 2072171 Maybridge1_005135 [O-][N+](=O)c1cccc(c1)c2csc(n2)c3ccncc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B10 compound treatment 733340.0 -145000.0 -0.83 710110.0 -220000.0 -1.1 734300.0 -134847.8125 -0.742377653589303 846270.0 -122255.625 -0.729485369137582 -1.7025 -0.9848 2072172 Maybridge1_005136 Clc1ccc(/C=N/NC(=S)NC2CC3CC2C=C3)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B11 compound treatment 638950.0 -240000.0 -1.37 683930.0 -247000.0 -1.23 605150.0 -263997.8125 -1.45338714038434 722080.0 -246445.625 -1.47051293325331 -2.7636 -0.9977 2072173 Maybridge1_005137 Cc1ccc(cc1)c2csc(n2)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B12 compound treatment 805380.0 -73400.0 -0.42 1017440.0 87000.0 0.44 756710.0 -112437.8125 -0.619003882013021 921440.0 -47085.625 -0.280954553495586 -0.4422 -0.4862 2072174 Maybridge1_005138 CNC(=S)N/N=C/c1cccc(c1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B13 compound treatment 860980.0 -17800.0 -0.1 1106160.0 176000.0 0.88 912240.0 43092.1875 0.237235417106082 948000.0 -20525.625 -0.122474063094476 0.4458 0.4824 2072175 Maybridge1_005139 CCc1cc2c(cc1c3csc(Nc4ccccc4Cl)n3)C(C)(C)CCC2(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B14 compound treatment 777230.0 -102000.0 -0.58 807380.0 -123000.0 -0.62 742930.0 -126217.8125 -0.694866915137571 852170.0 -116355.625 -0.694280742128299 -1.2925 -0.997 2072176 Maybridge1_005140 CNC(=S)N/N=C/c1ccc(OC)c(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B15 compound treatment 828920.0 -49900.0 -0.29 833220.0 -97200.0 -0.49 785980.0 -83167.8125 -0.457863752872559 985120.0 16594.375 0.0990167427673161 -0.5651 -0.771 2072177 Maybridge1_005141 CC(C)c1ccc(/C=N/NC(=O)N\N=C\c2ccc(cc2)C(C)C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B16 compound treatment 491680.0 -387000.0 -2.21 528750.0 -402000.0 -2.01 546970.0 -322177.8125 -1.77368549068814 681240.0 -287285.625 -1.71420055478875 -3.8543 -0.9948 2072178 Maybridge1_005142 COc1cc(cc(OC)c1OC)c2n[nH]c(=S)n2c3cccc(c3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B17 compound treatment 740320.0 -139000.0 -0.79 751900.0 -179000.0 -0.89 732800.0 -136347.8125 -0.750635603494007 863760.0 -104765.625 -0.625124534155827 -1.53 -0.9922 1912581 Maybridge1_005143 COc1ccc(/C=N/NC(=S)N)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B18 compound treatment 797340.0 -81500.0 -0.47 880930.0 -49500.0 -0.25 818080.0 -51067.8125 -0.281143624911887 992540.0 24014.375 0.143291036395939 -0.4255 -0.6925 1046961 Maybridge1_005144 O=C(NNC(=S)NC1CCCCC1)c2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B19 compound treatment 784900.0 -93900.0 -0.54 801820.0 -129000.0 -0.64 733070.0 -136077.8125 -0.749149172511161 927880.0 -40645.625 -0.242527808082063 -1.0858 -0.9444 1922073 Maybridge1_005145 CCOC(=O)N/N=C/c1ccc2OCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B20 compound treatment 745630.0 -133000.0 -0.76 705600.0 -225000.0 -1.12 626020.0 -243127.8125 -1.33849153071022 836430.0 -132095.625 -0.788199526725945 -2.0061 -0.9724 2072179 Maybridge1_005146 Cc1c(C)c(C)c(CSC2=NCN(Cc3cccnc3)CN2)c(C)c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B21 compound treatment 662560.0 -216000.0 -1.24 604410.0 -326000.0 -1.63 663200.0 -205947.8125 -1.13380447907229 732800.0 -235725.625 -1.40654791604323 -2.7032 -0.9904 2072180 Maybridge1_005147 CCOC(=O)N/N=C/c1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B22 compound treatment 28410.0 -850000.0 -4.86 31800.0 -899000.0 -4.49 28500.0 -840647.8125 -4.62801834874949 37310.0 -931215.625 -5.5564574141256 -9.7686 -0.9965 2072181 Maybridge1_005148 [O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B23 mock treatment 885410.0 6590.0 0.04 1007550.0 77100.0 0.39 904070.0 34922.1875 0.192257116625127 1117220.0 148694.375 0.887242374619221 0.7514 0.7612 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 B24 mock treatment 945060.0 66200.0 0.38 996270.0 65800.0 0.33 980680.0 111532.1875 0.614018144758056 1051770.0 83244.375 0.496709690253535 0.9091 0.9718 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C01 compound treatment 709760.0 -169000.0 -0.97 830590.0 -99900.0 -0.5 914240.0 45092.1875 0.248246016979021 1047520.0 78994.375 0.471350425034983 -0.3728 -0.3079 2072182 Maybridge1_005149 CCCCOc1cc(ccc1OC)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C02 compound treatment 276980.0 -602000.0 -3.44 270400.0 -660000.0 -3.3 327200.0 -541947.8125 -2.98358525772604 422160.0 -546365.625 -3.26010136251163 -6.4915 -0.9987 2072183 Maybridge1_005150 OC1(CC(=NN1)c2ccc3ccccc3c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C03 compound treatment 700200.0 -179000.0 -1.02 728830.0 -202000.0 -1.01 731920.0 -137227.8125 -0.755480267438101 793290.0 -175235.625 -1.04561098590907 -1.915 -0.9926 2072184 Maybridge1_005151 COC(=O)c1ccc2snnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C04 compound treatment 604960.0 -274000.0 -1.56 672190.0 -258000.0 -1.29 672850.0 -196297.8125 -1.08067833468536 763010.0 -205515.625 -1.22628829198383 -2.5816 -0.9909 1125721 Maybridge1_005152 O=C(NC1Cc2ccccc2C1)Nc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C05 compound treatment 601920.0 -277000.0 -1.58 600410.0 -330000.0 -1.65 608400.0 -260747.8125 -1.43549491559082 720580.0 -247945.625 -1.47946326215398 -3.0738 -0.9985 2072185 Maybridge1_005153 CC(C)(C)c1ccc(NC(=O)NCCSCc2ccco2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C06 compound treatment 537070.0 -342000.0 -1.95 579600.0 -351000.0 -1.75 531630.0 -337517.8125 -1.85813679171358 672180.0 -296345.625 -1.76826054134877 -3.6667 -0.9991 1693944 Maybridge1_005154 Clc1cc(Cl)cc(NC(=O)NC2Cc3ccccc3C2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C07 compound treatment 796930.0 -81900.0 -0.47 800640.0 -130000.0 -0.65 750450.0 -118697.8125 -0.65346705961532 960500.0 -8025.625 -0.0478879889222668 -0.9092 -0.8791 2072186 Maybridge1_005155 COc1cc(NC(=O)NCCSCc2ccco2)cc(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C08 compound treatment 670760.0 -208000.0 -1.19 694920.0 -236000.0 -1.18 707050.0 -162097.8125 -0.892397076858098 789820.0 -178705.625 -1.06631608009928 -2.1627 -0.994 2072187 Maybridge1_005156 Cn1c(SCc2c(Cl)cccc2Cl)nnc1c3ccc4ncccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C09 compound treatment 681550.0 -197000.0 -1.13 783270.0 -147000.0 -0.74 779300.0 -89847.8125 -0.494639156448175 810400.0 -158125.625 -0.943517567582153 -1.6506 -0.9616 2072188 Maybridge1_005157 Clc1ccc(cc1)C(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C10 compound treatment 676070.0 -203000.0 -1.16 737700.0 -193000.0 -0.96 706190.0 -162957.8125 -0.897131634803461 791410.0 -177115.625 -1.05682873146457 -2.0381 -0.9954 2072189 Maybridge1_005158 CC(C)n1c(nc2cc(ccc12)C(=O)O)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C11 compound treatment 743360.0 -135000.0 -0.77 694760.0 -236000.0 -1.18 692920.0 -176227.8125 -0.970186964960412 919740.0 -48785.625 -0.291098259583006 -1.607 -0.9256 2072190 Maybridge1_005159 COc1ccc(cc1)c2cc(nc(N)n2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C12 compound treatment 645670.0 -233000.0 -1.33 628660.0 -302000.0 -1.51 614020.0 -255127.8125 -1.40455512994786 709940.0 -258585.625 -1.54295092848936 -2.8944 -0.9983 1327971 Maybridge1_005160 CC(C)n1nnc2cc(ccc12)C(=O)Nc3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C13 compound treatment 765340.0 -113000.0 -0.65 745010.0 -185000.0 -0.93 940400.0 71252.1875 0.392264663317064 894170.0 -74355.625 -0.443671532909677 -0.8136 -0.637 2072191 Maybridge1_005161 CC(=O)Nc1ccc(cc1)S(=O)(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C14 compound treatment 719530.0 -159000.0 -0.91 897510.0 -32900.0 -0.16 716550.0 -152597.8125 -0.840096727461637 864800.0 -103725.625 -0.618918972784699 -1.2669 -0.9086 1942145 Maybridge1_005162 COc1ccc(cc1)c2cc(n3nc(cc3n2)c4ccccc4)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C15 compound treatment 703400.0 -175000.0 -1.0 745440.0 -185000.0 -0.93 743800.0 -125347.8125 -0.690077304192843 872080.0 -96445.625 -0.575480043186804 -1.5965 -0.9774 2072192 Maybridge1_005163 Cc1onc(c1C(=O)NCCSCc2ccco2)c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C16 compound treatment 699170.0 -180000.0 -1.03 668240.0 -262000.0 -1.31 750670.0 -118477.8125 -0.652255893629297 826970.0 -141555.625 -0.844646267659472 -1.9173 -0.9694 1549521 Maybridge1_005164 Cc1ccc2[nH]c(SCC(=O)NC3Cc4ccccc4C3)nc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C17 compound treatment 671250.0 -208000.0 -1.19 750600.0 -180000.0 -0.9 746170.0 -122977.8125 -0.67702974334341 844480.0 -124045.625 -0.740166094959042 -1.7513 -0.9757 2072193 Maybridge1_005165 FC(F)(F)c1cc(nc2cc(nn12)c3ccccc3)c4ccc(Cl)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C18 compound treatment 793730.0 -85100.0 -0.49 783570.0 -147000.0 -0.73 781980.0 -87167.8125 -0.479884952618437 886180.0 -82345.625 -0.491346951520553 -1.096 -0.9812 2072194 Maybridge1_005166 CC(C)(C)OC(=O)NCc1nnc(S)n1CC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C19 compound treatment 731380.0 -147000.0 -0.84 801600.0 -129000.0 -0.64 781490.0 -87657.8125 -0.482582549587307 852050.0 -116475.625 -0.694996768440352 -1.3322 -0.9819 2072195 Maybridge1_005167 FC(F)(F)c1c(cnn1c2ccccc2)C(=O)NCCSCc3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C20 compound treatment 684640.0 -194000.0 -1.11 759790.0 -171000.0 -0.85 743210.0 -125937.8125 -0.69332543115536 851620.0 -116905.625 -0.697562529391876 -1.6769 -0.9802 1065781 Maybridge1_005168 O=C(NC1CCCC1)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C21 compound treatment 697480.0 -181000.0 -1.04 720490.0 -210000.0 -1.05 726630.0 -142517.8125 -0.784603304102024 804590.0 -163935.625 -0.978185174857395 -1.9244 -0.994 2072196 Maybridge1_005169 CC(C)(C)c1cc2c(CCC2(C)C)c(c1)c3cc(n4nc(cc4n3)c5ccccc5)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C22 compound treatment 737600.0 -141000.0 -0.81 716190.0 -214000.0 -1.07 694730.0 -174417.8125 -0.960222372075402 867720.0 -100805.625 -0.601495665858071 -1.7201 -0.9796 2072197 Maybridge1_005170 CCOC(=O)c1ccc2nc(cc(N3CCN(Cc4ccccc4)CC3)c2c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C23 mock treatment 780330.0 -98500.0 -0.56 788550.0 -142000.0 -0.71 812360.0 -56787.8125 -0.312633940548493 960430.0 -8095.625 -0.0483056709376312 -0.8167 -0.8513 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 C24 mock treatment 788750.0 -90100.0 -0.51 788430.0 -142000.0 -0.71 786170.0 -82977.8125 -0.456817745884629 857150.0 -111375.625 -0.664565650178091 -1.1731 -0.9846 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D01 compound treatment 747150.0 -132000.0 -0.75 769050.0 -161000.0 -0.81 885870.0 16722.1875 0.0920606577813813 913760.0 -54765.625 -0.326780237466991 -0.8971 -0.7771 2072198 Maybridge1_005171 CSc1nc2ccc(NS(=O)(=O)c3ccc(cc3)[N+](=O)[O-])cc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D02 compound treatment 724170.0 -155000.0 -0.88 739330.0 -191000.0 -0.96 776080.0 -93067.8125 -0.512366222243607 861120.0 -107405.625 -0.640877113020997 -1.4963 -0.9725 2072199 Maybridge1_005172 CCOC(=O)N/N=C/c1ccccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D03 compound treatment 664170.0 -215000.0 -1.23 693880.0 -237000.0 -1.18 701330.0 -167817.8125 -0.923887392494703 769440.0 -199085.625 -1.18792121542965 -2.2606 -0.9944 2072200 Maybridge1_005173 Cc1cc2CN(Cc2cc1C)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D04 compound treatment 687880.0 -191000.0 -1.09 835770.0 -94700.0 -0.47 787120.0 -82027.8125 -0.451587710944983 854080.0 -114445.625 -0.682883989994786 -1.3494 -0.9347 2072201 Maybridge1_005174 Clc1ccccc1NC(=S)NNc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D05 compound treatment 735550.0 -143000.0 -0.82 781300.0 -149000.0 -0.75 729120.0 -140027.8125 -0.770895107260215 866560.0 -101965.625 -0.608417253541252 -1.4719 -0.9944 1245333 Maybridge1_005175 COc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D06 compound treatment 690430.0 -188000.0 -1.08 748670.0 -182000.0 -0.91 741450.0 -127697.8125 -0.703014759043546 791780.0 -176745.625 -1.05462098366908 -1.8715 -0.9876 2072202 Maybridge1_005176 COc1cc(/C=N/NC(=O)N\N=C\c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D07 compound treatment 663530.0 -215000.0 -1.23 714350.0 -216000.0 -1.08 705210.0 -163937.8125 -0.902526828741201 816390.0 -152135.625 -0.90777592083883 -2.0605 -0.9914 2072203 Maybridge1_005177 S(c1ccccc1)c2nc3ccccc3nc2Sc4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D08 compound treatment 695900.0 -183000.0 -1.04 703400.0 -227000.0 -1.14 717280.0 -151867.8125 -0.836077858508014 852640.0 -115885.625 -0.691476305739424 -1.8541 -0.9828 2072204 Maybridge1_005178 Clc1cccc(Cl)c1/C=N/NC(=S)NC2CC3CC2C=C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D09 compound treatment 714400.0 -164000.0 -0.94 692970.0 -237000.0 -1.19 680200.0 -188947.8125 -1.0402143801523 808820.0 -159705.625 -0.95294524735752 -2.0601 -0.9954 2072205 Maybridge1_005179 [O-][N+](=O)c1ccc(cc1)c2csc(n2)c3ccncc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D10 compound treatment 771520.0 -107000.0 -0.61 757010.0 -173000.0 -0.87 715060.0 -154087.8125 -0.848299624366977 855700.0 -112825.625 -0.673217634782067 -1.501 -0.9895 2072206 Maybridge1_005180 C/C(=N\NC(=O)N/N=C(\C)/c1ccc(cc1)[N+](=O)[O-])/c2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D11 compound treatment 600980.0 -278000.0 -1.59 658270.0 -272000.0 -1.36 631870.0 -237277.8125 -1.30628552608188 713920.0 -254605.625 -1.51920272247293 -2.887 -0.9969 2072207 Maybridge1_005181 Brc1ccc(cc1)c2csc(n2)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D12 compound treatment 743080.0 -136000.0 -0.78 663450.0 -267000.0 -1.34 653280.0 -215867.8125 -1.18841705444206 821330.0 -147195.625 -0.878299504325973 -2.0888 -0.9773 2072208 Maybridge1_005182 CNC(=S)N/N=C/c1ccc(OC)c(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D13 compound treatment 602740.0 -276000.0 -1.58 709200.0 -221000.0 -1.11 651720.0 -217427.8125 -1.19700532234296 743360.0 -225165.625 -1.34353760058254 -2.6121 -0.9909 2072209 Maybridge1_005183 CCOc1ccc(/C=N/NC(=S)N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D14 compound treatment 750270.0 -129000.0 -0.73 699440.0 -231000.0 -1.16 706740.0 -162407.8125 -0.894103719838403 828320.0 -140205.625 -0.836590971648874 -1.8102 -0.9856 2072210 Maybridge1_005184 CNC(=S)N/N=C/c1cc(OC)c(OC)c(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D15 compound treatment 710670.0 -168000.0 -0.96 796010.0 -134000.0 -0.67 800230.0 -68917.8125 -0.379413228777868 1000980.0 32454.375 0.193651553677015 -0.9094 -0.729 2072211 Maybridge1_005185 Clc1cccc(Cl)c1/C=N/NC(=O)N\N=C\c2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D16 compound treatment 782410.0 -96400.0 -0.55 741160.0 -189000.0 -0.95 727480.0 -141667.8125 -0.779923799156025 882690.0 -85835.625 -0.512171383429433 -1.3948 -0.9694 2072212 Maybridge1_005186 COc1ccc(NC(=S)NNC(=O)c2ccncc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D17 compound treatment 611480.0 -267000.0 -1.53 618130.0 -312000.0 -1.56 596060.0 -273087.8125 -1.50343031680685 775730.0 -192795.625 -1.15038950290619 -2.8716 -0.9934 2072213 Maybridge1_005187 NC(=S)N/N=C/c1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D18 compound treatment 731370.0 -147000.0 -0.84 673280.0 -257000.0 -1.29 698450.0 -170697.8125 -0.939742656311735 802370.0 -166155.625 -0.99143166163038 -2.0299 -0.987 2072214 Maybridge1_005188 COc1cc(cc(OC)c1OC)C(=O)N/N=C\2/C(=O)Nc3ccc(Br)cc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D19 compound treatment 604500.0 -274000.0 -1.57 710750.0 -220000.0 -1.1 677760.0 -191387.8125 -1.05364731199729 762520.0 -206005.625 -1.22921206609138 -2.4744 -0.9871 2072215 Maybridge1_005189 Oc1ccc2ccccc2c1/C=N/NC(=O)N\N=C\c3c(O)ccc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D20 compound treatment 709320.0 -170000.0 -0.97 695160.0 -235000.0 -1.18 713160.0 -155987.8125 -0.858759694246269 805410.0 -163115.625 -0.973292328391698 -1.9886 -0.9934 2072216 Maybridge1_005190 Brc1ccc(CSC2=NCN(Cc3cccnc3)CN2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D21 compound treatment 698690.0 -180000.0 -1.03 699520.0 -231000.0 -1.16 693250.0 -175897.8125 -0.968370215981377 860380.0 -108145.625 -0.645292608611992 -1.8989 -0.9809 2072217 Maybridge1_005191 CCOC(=O)N/N=C/c1cccc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D22 compound treatment 494940.0 -384000.0 -2.19 560920.0 -370000.0 -1.85 538970.0 -330177.8125 -1.81772789017989 640110.0 -328415.625 -1.95961857324499 -3.9093 -0.9972 2072218 Maybridge1_005192 Nc1ccc2C=CS(=O)(=O)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D23 mock treatment 765850.0 -113000.0 -0.65 762640.0 -168000.0 -0.84 825490.0 -43657.8125 -0.240349352382648 890040.0 -78485.625 -0.468314771816175 -1.0967 -0.9275 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 D24 mock treatment 935520.0 56700.0 0.32 970560.0 40100.0 0.2 845800.0 -23347.8125 -0.128536710672952 996220.0 27694.375 0.165249176632238 0.2806 0.6455 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E01 compound treatment 825850.0 -53000.0 -0.3 876740.0 -53700.0 -0.27 923040.0 53892.1875 0.296692656419953 993670.0 25144.375 0.150033617501107 -0.0623 -0.1189 2072219 Maybridge1_005193 CCCCOc1cc(ccc1OC)C(=O)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E02 compound treatment 784910.0 -93900.0 -0.54 766650.0 -164000.0 -0.82 825170.0 -43977.8125 -0.242111048362318 980850.0 12324.375 0.0735381398300895 -0.7622 -0.7535 2072220 Maybridge1_005194 COC(=O)c1ccc(NC(C)C)c(c1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E03 compound treatment 517690.0 -361000.0 -2.06 559450.0 -371000.0 -1.86 541830.0 -327317.8125 -1.80198273236159 586590.0 -381935.625 -2.27896630842072 -3.9998 -0.9956 1042155 Maybridge1_005195 Clc1cccc(NC(=O)Nc2cccc(Cl)c2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E04 compound treatment 769620.0 -109000.0 -0.62 776570.0 -154000.0 -0.77 774130.0 -95017.8125 -0.523101557119722 936020.0 -32505.625 -0.193957356581121 -1.0553 -0.9281 2072221 Maybridge1_005196 Cn1c(SCC(=O)N2CCOCC2)nnc1c3ccc4ncccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E05 compound treatment 682920.0 -196000.0 -1.12 717060.0 -213000.0 -1.07 717820.0 -151327.8125 -0.833104996542321 835360.0 -133165.625 -0.794584094675086 -1.907 -0.9892 2072222 Maybridge1_005197 CCCCc1ccc(NC(=O)NCCSCc2ccco2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E06 compound treatment 662110.0 -217000.0 -1.24 774300.0 -156000.0 -0.78 622190.0 -246957.8125 -1.3595768294669 785370.0 -183155.625 -1.09286872250458 -2.2357 -0.9818 1306801 Maybridge1_005198 COc1cc(NC(=O)NC2Cc3ccccc3C2)cc(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E07 compound treatment 997810.0 119000.0 0.68 767620.0 -163000.0 -0.81 760980.0 -108167.8125 -0.595496251284297 906350.0 -62175.625 -0.370994862236276 -0.5506 -0.4329 2072223 Maybridge1_005199 COc1ccc(cc1)c2cc(n3nc(cc3n2)C(C)(C)C)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E08 compound treatment 623520.0 -255000.0 -1.46 601710.0 -329000.0 -1.64 609920.0 -259227.8125 -1.42712685968738 727840.0 -240685.625 -1.43614367027476 -2.983 -0.9982 1576756 Maybridge1_005200 Clc1ccc(cc1)C(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E09 compound treatment 741190.0 -138000.0 -0.79 817390.0 -113000.0 -0.57 761690.0 -107457.8125 -0.591587488329403 920250.0 -48275.625 -0.28805514775678 -1.1157 -0.9529 2072224 Maybridge1_005201 CCOc1ccccc1NC(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E10 compound treatment 701380.0 -177000.0 -1.01 815930.0 -115000.0 -0.57 772420.0 -96727.8125 -0.532515620011085 864800.0 -103725.625 -0.618918972784699 -1.3689 -0.9627 1497192 Maybridge1_005202 CCOc1ccccc1NC(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E11 compound treatment 711070.0 -168000.0 -0.96 833400.0 -97100.0 -0.49 753800.0 -115347.8125 -0.635024304828148 916080.0 -52445.625 -0.312937062100629 -1.1958 -0.9295 2072225 Maybridge1_005203 CC(C)(C)c1cc2nc(cc(n2n1)C(F)(F)F)c3ccc4CCCc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E12 compound treatment 660230.0 -219000.0 -1.25 670030.0 -260000.0 -1.3 690440.0 -178707.8125 -0.983840108802856 768210.0 -200315.625 -1.19526048512819 -2.3652 -0.9948 2072226 Maybridge1_005204 FC(F)(F)c1ccc(Cl)c(c1)S(=O)(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E13 compound treatment 710950.0 -168000.0 -0.96 1074110.0 144000.0 0.72 766190.0 -102957.8125 -0.56681363861529 828530.0 -139995.625 -0.835337925602781 -0.8213 -0.5242 1738674 Maybridge1_005205 COC(=O)c1ccc(Cn2nnc3ccccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E14 compound treatment 729130.0 -150000.0 -0.86 769070.0 -161000.0 -0.81 871770.0 2622.1875 0.0144359286771612 852510.0 -116015.625 -0.692252000910815 -1.1701 -0.8574 1433447 Maybridge1_005206 COc1cccc(SCC(=O)NC2Cc3ccccc3C2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E15 compound treatment 749920.0 -129000.0 -0.74 757350.0 -173000.0 -0.87 775100.0 -94047.8125 -0.517761416181347 885600.0 -82925.625 -0.494807745362143 -1.3074 -0.9732 2072227 Maybridge1_005207 O=S(=O)(NCCSCc1ccco1)c2cccc3nonc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E16 compound treatment 758020.0 -121000.0 -0.69 769760.0 -161000.0 -0.8 703860.0 -165287.8125 -0.909958983655435 840320.0 -128205.625 -0.764988340443553 -1.5844 -0.995 1496993 Maybridge1_005208 O=C(CSc1nnc(SCC(=O)NC2Cc3ccccc3C2)s1)NC4Cc5ccccc5C4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E17 compound treatment 663410.0 -215000.0 -1.23 677190.0 -253000.0 -1.27 698080.0 -171067.8125 -0.941779617288229 772400.0 -196125.625 -1.17025923306567 -2.3047 -0.994 2072228 Maybridge1_005209 Cc1cc2nc(cc(n2n1)C(F)(F)F)c3ccc4ccccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E18 compound treatment 935160.0 56300.0 0.32 746980.0 -183000.0 -0.92 744890.0 -124257.8125 -0.684076527262091 862730.0 -105795.625 -0.631270426667617 -0.9556 -0.7099 2072229 Maybridge1_005210 CCCCn1c(S)nnc1CNC(=O)OC(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E19 compound treatment 784770.0 -94100.0 -0.54 901920.0 -28500.0 -0.14 744900.0 -124247.8125 -0.684021474262726 912770.0 -55755.625 -0.33268745454143 -0.8484 -0.9005 2072230 Maybridge1_005211 O=S(=O)(NCCSCc1ccco1)c2cc(cs2)S(=O)(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E20 compound treatment 733370.0 -145000.0 -0.83 756200.0 -174000.0 -0.87 785600.0 -83547.8125 -0.459955766848417 867840.0 -100685.625 -0.600779639546018 -1.3816 -0.9715 2072231 Maybridge1_005212 CCOC(=O)C1CCN(CC1)c2cc(nc3c(F)cccc23)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E21 compound treatment 775270.0 -104000.0 -0.59 739880.0 -191000.0 -0.95 759090.0 -110057.8125 -0.605901268164224 881810.0 -86715.625 -0.517422243051157 -1.334 -0.9695 2072232 Maybridge1_005213 [O-][N+](=O)c1cccc(c1)c2cc(n3nc(cc3n2)c4ccco4)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E22 compound treatment 495130.0 -384000.0 -2.19 589460.0 -341000.0 -1.71 498960.0 -370187.8125 -2.03799494063804 537700.0 -430825.625 -2.57068736172306 -4.253 -0.9895 2072233 Maybridge1_005214 OC1(CC(=NN1)c2ccccc2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E23 mock treatment 828270.0 -50600.0 -0.29 848540.0 -81900.0 -0.41 850670.0 -18477.8125 -0.101725899982346 931080.0 -37445.625 -0.223433773093978 -0.5118 -0.917 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 E24 mock treatment 822600.0 -56200.0 -0.32 1101370.0 171000.0 0.85 976600.0 107452.1875 0.591556521017261 948330.0 -20195.625 -0.120504990736329 0.5024 0.4589 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F01 compound treatment 784210.0 -94600.0 -0.54 799380.0 -131000.0 -0.66 898400.0 29252.1875 0.161042065985344 836080.0 -132445.625 -0.790287936802766 -0.9127 -0.7791 1592040 Maybridge1_005215 CSc1nc2ccc(NS(=O)(=O)c3ccc(NC(=O)C)cc3)cc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F02 compound treatment 712670.0 -166000.0 -0.95 749760.0 -181000.0 -0.9 774170.0 -94977.8125 -0.522881345122264 820290.0 -148235.625 -0.884505065697101 -1.6301 -0.9789 2072234 Maybridge1_005216 CCOC(=O)N/N=C/c1ccco1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F03 compound treatment 744520.0 -134000.0 -0.77 771890.0 -159000.0 -0.79 789970.0 -79177.8125 -0.435897606126045 849240.0 -119285.625 -0.711763717914265 -1.354 -0.9786 1040140 Maybridge1_005217 Cc1ccc(CC(=O)O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F04 compound treatment 730720.0 -148000.0 -0.85 794690.0 -136000.0 -0.68 707680.0 -161467.8125 -0.888928737898122 840670.0 -127855.625 -0.762899930366731 -1.5885 -0.9949 2072235 Maybridge1_005218 [O-][N+](=O)c1cccc(c1)C(=O)CSC2=NCCCCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F05 compound treatment 722510.0 -156000.0 -0.89 781390.0 -149000.0 -0.75 716590.0 -152557.8125 -0.839876515464178 824840.0 -143685.625 -0.857355734698417 -1.6679 -0.9979 1080225 Maybridge1_005219 COc1ccc(CCNC(=O)c2ccc(Cl)c(Cl)c2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F06 compound treatment 783390.0 -95400.0 -0.55 741360.0 -189000.0 -0.95 763060.0 -106087.8125 -0.58404522741644 845190.0 -123335.625 -0.73592960594606 -1.4055 -0.9758 2072236 Maybridge1_005220 CCOC(=O)N/N=C/c1ccc(OC)c(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F07 compound treatment 752170.0 -127000.0 -0.72 1177230.0 247000.0 1.23 1010590.0 141442.1875 0.778681665857859 964380.0 -4145.625 -0.0247364714992131 0.6324 0.3882 1116092 Maybridge1_005221 Oc1c([N+](=O)[O-])c(=O)oc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F08 compound treatment 628380.0 -250000.0 -1.43 676580.0 -254000.0 -1.27 670410.0 -198737.8125 -1.09411126653034 789850.0 -178675.625 -1.06613707352126 -2.4303 -0.9928 2072237 Maybridge1_005222 Oc1ccc(Cl)cc1/C=N/NC(=O)N\N=C\c2cc(Cl)ccc2O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F09 compound treatment 748550.0 -130000.0 -0.74 780160.0 -150000.0 -0.75 752000.0 -117147.8125 -0.644933844713793 925620.0 -42905.625 -0.256012970292399 -1.1984 -0.9473 2072238 Maybridge1_005223 c1nc(sc1c2ccc(cc2)c3ccccc3)c4ccncc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F10 compound treatment 452250.0 -427000.0 -2.44 529990.0 -400000.0 -2.0 461410.0 -407737.8125 -2.24471895325247 527610.0 -440915.625 -2.63089324079487 -4.6577 -0.9951 2072239 Maybridge1_005224 C/C(=N\NC(=O)N/N=C(\C)/c1ccc2ccccc2c1)/c3ccc4ccccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F11 compound treatment 713940.0 -165000.0 -0.94 693160.0 -237000.0 -1.19 671960.0 -197187.8125 -1.08557805162881 785830.0 -182695.625 -1.09012395497505 -2.1522 -0.9967 2072240 Maybridge1_005225 [O-][N+](=O)c1ccc(cc1)c2csc(n2)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F12 compound treatment 825530.0 -53300.0 -0.3 691720.0 -239000.0 -1.19 719090.0 -150057.8125 -0.826113265623005 857620.0 -110905.625 -0.661761213789216 -1.4932 -0.9192 2072241 Maybridge1_005226 CNC(=S)N/N=C/c1cc(Br)cc(Br)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F13 compound treatment 731760.0 -147000.0 -0.84 780770.0 -150000.0 -0.75 731430.0 -137717.8125 -0.758177864406971 858020.0 -110505.625 -0.659374459415705 -1.5032 -0.9964 2072242 Maybridge1_005227 COc1cccc(/C=N/NC(=S)NCCc2ccccc2)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F14 compound treatment 746640.0 -132000.0 -0.76 773890.0 -157000.0 -0.78 832610.0 -36537.8125 -0.201151616834985 840640.0 -127885.625 -0.763078936944745 -1.2512 -0.931 1333393 Maybridge1_005228 COc1ccc(cc1)n2c(n[nH]c2=S)c3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F15 compound treatment 751150.0 -128000.0 -0.73 785920.0 -145000.0 -0.72 777440.0 -91707.8125 -0.504879014330008 899310.0 -69215.625 -0.413001739210064 -1.1851 -0.9741 2072243 Maybridge1_005229 CC(=O)Nc1ccc(/C=N/NC(=O)N\N=C\c2ccc(NC(=O)C)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F16 compound treatment 760160.0 -119000.0 -0.68 837920.0 -92500.0 -0.46 754240.0 -114907.8125 -0.632601972856101 895650.0 -72875.625 -0.434840541727687 -1.1041 -0.9824 2072244 Maybridge1_005230 Cc1cccc(C)c1NC(=S)NNC(=O)c2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F17 compound treatment 750300.0 -129000.0 -0.73 769240.0 -161000.0 -0.81 757390.0 -111757.8125 -0.615260278056222 877450.0 -91075.625 -0.543437865722423 -1.3496 -0.9888 2072245 Maybridge1_005231 O=C(N/N=C/c1ccncc1)N/N=C/c2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F18 compound treatment 744380.0 -134000.0 -0.77 820850.0 -110000.0 -0.55 769550.0 -99597.8125 -0.548315830828753 883220.0 -85305.625 -0.509008933884532 -1.1868 -0.9855 2072246 Maybridge1_005232 Cn1c(S)nnc1c2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F19 compound treatment 778080.0 -101000.0 -0.58 792840.0 -138000.0 -0.69 747210.0 -121937.8125 -0.671304231409482 911890.0 -56635.625 -0.337938314163153 -1.1365 -0.9711 2072247 Maybridge1_005233 CCOC(=O)NNC(=S)Nc1ccccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F20 compound treatment 752440.0 -126000.0 -0.72 765760.0 -165000.0 -0.82 715120.0 -154027.8125 -0.847969306370788 840130.0 -128395.625 -0.766122048770971 -1.5799 -0.9981 2072248 Maybridge1_005234 CCOC(=O)N/N=C(\C)/c1ccc(OC)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F21 compound treatment 745850.0 -133000.0 -0.76 752180.0 -178000.0 -0.89 707080.0 -162067.8125 -0.892231917860003 849120.0 -119405.625 -0.712479744226318 -1.628 -0.9952 2072249 Maybridge1_005235 CCOC(=O)N/N=C/c1ccccc1OCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F22 compound treatment 823630.0 -55200.0 -0.32 773030.0 -157000.0 -0.79 780740.0 -88407.8125 -0.486711524539659 874500.0 -94025.625 -0.561040179227065 -1.0752 -0.9537 1087914 Maybridge1_005236 CC(=O)c1ccc(cc1Cl)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F23 mock treatment 903720.0 24900.0 0.14 861080.0 -69400.0 -0.35 777920.0 -91227.8125 -0.502236470360503 952820.0 -15705.625 -0.093713672893672 -0.4004 -0.6317 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 F24 mock treatment 929860.0 51000.0 0.29 877210.0 -53200.0 -0.27 844430.0 -24717.8125 -0.136078971585915 967630.0 -895.625 -0.00534409221443878 -0.0581 -0.1391 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G01 compound treatment 926560.0 47700.0 0.27 805400.0 -125000.0 -0.63 908370.0 39222.1875 0.215929906351945 1021190.0 52664.375 0.314242318398642 0.0887 0.1135 1043563 Maybridge1_005237 Nc1ccccc1NC2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G02 compound treatment 776670.0 -102000.0 -0.58 762840.0 -168000.0 -0.84 785280.0 -83867.8125 -0.461717462828087 967160.0 -1365.625 -0.00814852860331384 -0.9459 -0.8438 2072250 Maybridge1_005238 Cc1cc(NC(=O)c2ccc3nonc3c2)no1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G03 compound treatment 663360.0 -215000.0 -1.23 642720.0 -288000.0 -1.44 675940.0 -193207.8125 -1.06366695788166 737390.0 -231135.625 -1.37915990960719 -2.5564 -0.9936 1536217 Maybridge1_005239 COC(=O)c1sccc1NC(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G04 compound treatment 736500.0 -142000.0 -0.81 781480.0 -149000.0 -0.75 821600.0 -47547.8125 -0.261764969135514 886090.0 -82435.625 -0.491883971254593 -1.1559 -0.9355 2072251 Maybridge1_005240 CC(C)NC(=O)CSc1nnc(c2ccc3ncccc3c2)n1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G05 compound treatment 758200.0 -121000.0 -0.69 775750.0 -155000.0 -0.77 753600.0 -115547.8125 -0.636125364815442 895620.0 -72905.625 -0.4350195483057 -1.267 -0.9812 2072252 Maybridge1_005241 COc1ccc(Cl)cc1NC(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G06 compound treatment 716200.0 -163000.0 -0.93 712100.0 -218000.0 -1.09 651970.0 -217177.8125 -1.19562899735884 775290.0 -193235.625 -1.15301493271705 -2.1849 -0.9957 1639001 Maybridge1_005242 COc1cccc(NC(=O)NC2Cc3ccccc3C2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G07 compound treatment 714640.0 -164000.0 -0.94 724750.0 -206000.0 -1.03 726740.0 -142407.8125 -0.783997721109013 918770.0 -49755.625 -0.296886138938769 -1.5238 -0.9377 2072253 Maybridge1_005243 Fc1ccc(NC(=O)NCCSCc2ccco2)c(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G08 compound treatment 741970.0 -137000.0 -0.78 823480.0 -107000.0 -0.54 743920.0 -125227.8125 -0.689416668200466 894450.0 -74075.625 -0.442000804848219 -1.2241 -0.9775 1301968 Maybridge1_005244 CC(C)n1nnc2cc(ccc12)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G09 compound treatment 717400.0 -161000.0 -0.92 742020.0 -188000.0 -0.94 770350.0 -98797.8125 -0.543911590879577 797320.0 -171205.625 -1.02156443559595 -1.715 -0.9775 2072254 Maybridge1_005245 Brc1cncc(c1)C(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G10 compound treatment 617010.0 -262000.0 -1.5 684960.0 -245000.0 -1.23 745080.0 -124067.8125 -0.683030520274162 806240.0 -162285.625 -0.968339813066664 -2.1874 -0.964 1511751 Maybridge1_005246 O=C(NC1Cc2ccccc2C1)Nc3cccc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G11 compound treatment 617980.0 -261000.0 -1.49 652220.0 -278000.0 -1.39 599410.0 -269737.8125 -1.48498756201968 676480.0 -292045.625 -1.74260293183353 -3.0546 -0.9964 2072255 Maybridge1_005247 FC(F)(F)c1cc(nc2cc(nn12)c3ccco3)c4ccco4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G12 compound treatment 783860.0 -95000.0 -0.54 702350.0 -228000.0 -1.14 703420.0 -165727.8125 -0.912381315627482 837650.0 -130875.625 -0.780919925886737 -1.6883 -0.9686 1330371 Maybridge1_005248 COc1ccc(Cl)cc1S(=O)(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G13 compound treatment 710940.0 -168000.0 -0.96 842690.0 -87800.0 -0.44 725860.0 -143287.8125 -0.788842385053106 821880.0 -146645.625 -0.875017717062396 -1.5309 -0.9682 2072256 Maybridge1_005249 CS(=O)(=NC(=O)c1ccc2nnsc2c1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G14 compound treatment 636640.0 -242000.0 -1.38 648640.0 -282000.0 -1.41 930520.0 61372.1875 0.337872299944745 703220.0 -265305.625 -1.58304840196434 -2.0191 -0.7907 1139185 Maybridge1_005250 COc1ccc(cc1)c2ccnc(SCC(=O)NC3Cc4ccccc4C3)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G15 compound treatment 711450.0 -167000.0 -0.96 727140.0 -203000.0 -1.02 732230.0 -136917.8125 -0.753773624457795 841310.0 -127215.625 -0.759081123369114 -1.7429 -0.9911 2072257 Maybridge1_005251 O=C(NCc1ccc(s1)S(=O)(=O)NCCSCc2ccco2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G16 compound treatment 685600.0 -193000.0 -1.1 844100.0 -86400.0 -0.43 688670.0 -180477.8125 -0.993584489690407 802500.0 -166025.625 -0.990655966458989 -1.76 -0.9582 1248175 Maybridge1_005252 Fc1ccc(SCC(=O)NC2Cc3ccccc3C2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G17 compound treatment 758370.0 -120000.0 -0.69 731070.0 -199000.0 -1.0 736820.0 -132327.8125 -0.7285042977494 891380.0 -77145.625 -0.460319144664914 -1.4371 -0.9666 2072258 Maybridge1_005253 Brc1cncc(c1)C(=O)NNC(=O)c2ccc3ncccc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G18 compound treatment 703800.0 -175000.0 -1.0 968770.0 38300.0 0.19 686400.0 -182747.8125 -1.00608152054619 762240.0 -206285.625 -1.23088279415284 -1.5226 -0.8066 2072259 Maybridge1_005254 FC(F)(F)c1cc(nc2cc(nn12)C3CC3)c4ccc5ccccc5c4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G19 compound treatment 597160.0 -282000.0 -1.61 720910.0 -210000.0 -1.05 651800.0 -217347.8125 -1.19656489834804 785760.0 -182765.625 -1.09054163699041 -2.4721 -0.9842 2072260 Maybridge1_005255 Clc1ccc(cc1)S(=O)(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G20 compound treatment 777140.0 -102000.0 -0.58 735940.0 -195000.0 -0.97 712520.0 -156627.8125 -0.862283086205609 826260.0 -142265.625 -0.848882756672454 -1.6325 -0.9848 2072261 Maybridge1_005256 Cn1c(SCC(=O)O)nnc1c2ccc3ncccc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G21 compound treatment 714470.0 -164000.0 -0.94 710260.0 -220000.0 -1.1 701440.0 -167707.8125 -0.923281809501691 855940.0 -112585.625 -0.671785582157961 -1.8176 -0.986 2072262 Maybridge1_005257 [O-][N+](=O)c1cccc(c1)c2cc(n3nc(cc3n2)C4CC4)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G22 compound treatment 708480.0 -170000.0 -0.97 759370.0 -171000.0 -0.86 711870.0 -157277.8125 -0.865861531164314 845600.0 -122925.625 -0.733483182713212 -1.7141 -0.9951 1703981 Maybridge1_005258 OC(=O)c1ccc(Cn2cnc3ccccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G23 mock treatment 770090.0 -109000.0 -0.62 818570.0 -112000.0 -0.56 774530.0 -94617.8125 -0.520899437145135 896320.0 -72205.625 -0.430842728152057 -1.0662 -0.9917 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 G24 mock treatment 888200.0 9380.0 0.05 1074880.0 144000.0 0.72 875720.0 6572.1875 0.0361818634262157 955640.0 -12885.625 -0.0768870545604217 0.3676 0.5041 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H01 compound treatment 699260.0 -180000.0 -1.03 708370.0 -222000.0 -1.11 771080.0 -98067.8125 -0.539892721925954 820170.0 -148355.625 -0.885221092009154 -1.7808 -0.9714 1553141 Maybridge1_005259 CSc1nc2ccc(NC(=O)c3c(C)onc3c4ccccc4)cc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H02 compound treatment 723870.0 -155000.0 -0.89 832610.0 -97800.0 -0.49 763230.0 -105917.8125 -0.58310932642724 844170.0 -124355.625 -0.742015829598513 -1.3498 -0.9758 2072263 Maybridge1_005260 CCOC(=O)N/N=C/c1cccs1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H03 compound treatment 701720.0 -177000.0 -1.01 712170.0 -218000.0 -1.09 711330.0 -157817.8125 -0.868834393130008 825360.0 -143165.625 -0.854252954012853 -1.9133 -0.9946 2072264 Maybridge1_005261 COc1cc2Cc3c(OC)c(OC)c(OC)cc3Cc2c(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H04 compound treatment 708090.0 -171000.0 -0.98 712970.0 -217000.0 -1.09 690730.0 -178417.8125 -0.98224357182128 862890.0 -105635.625 -0.630315724918213 -1.8378 -0.9828 1912813 Maybridge1_005262 Oc1ccccc1/C=N/c2nccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H05 compound treatment 644830.0 -234000.0 -1.34 681970.0 -248000.0 -1.24 658840.0 -210307.8125 -1.15780758679529 780350.0 -188175.625 -1.12282248989214 -2.4301 -0.9977 2072265 Maybridge1_005263 COC(=O)c1ccc(s1)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H06 compound treatment 726790.0 -152000.0 -0.87 810640.0 -120000.0 -0.6 844680.0 -24467.8125 -0.134702646601798 798680.0 -169845.625 -1.01344947072602 -1.308 -0.8902 2072266 Maybridge1_005264 Clc1ccccc1/C=N/NC(=S)NC2CC3CCC2C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H07 compound treatment 727010.0 -152000.0 -0.87 785690.0 -145000.0 -0.72 765360.0 -103787.8125 -0.57138303756256 864990.0 -103535.625 -0.617785264457281 -1.3902 -0.9869 2072267 Maybridge1_005265 Nc1c([N+](=O)[O-])c(=O)oc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H08 compound treatment 651360.0 -227000.0 -1.3 701160.0 -229000.0 -1.15 690970.0 -178177.8125 -0.980922299836527 775250.0 -193275.625 -1.1532536081544 -2.2902 -0.9952 2072268 Maybridge1_005266 CCOC(=O)N/N=C/c1cc(Cl)ccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H09 compound treatment 645440.0 -233000.0 -1.33 673280.0 -257000.0 -1.29 666830.0 -202317.8125 -1.1138202403029 744450.0 -224075.625 -1.33703369491473 -2.5352 -0.9974 1671736 Maybridge1_005267 CCOC(=O)c1ccc(NC(=S)NN)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H10 compound treatment 721720.0 -157000.0 -0.9 744770.0 -186000.0 -0.93 721760.0 -147387.8125 -0.811414114792631 864400.0 -104125.625 -0.62130572715821 -1.6294 -0.9894 2072269 Maybridge1_005268 O=C(N/N=C/c1cccnc1)N/N=C/c2cccnc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H11 compound treatment 656270.0 -223000.0 -1.27 628590.0 -302000.0 -1.51 642610.0 -226537.8125 -1.24715860476419 688600.0 -279925.625 -1.67028427431616 -2.8493 -0.9925 2072270 Maybridge1_005269 Cc1ccc(cc1)c2csc(Nc3ccccc3Cl)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H12 compound treatment 489500.0 -389000.0 -2.22 411940.0 -519000.0 -2.59 405600.0 -463547.8125 -2.55196974270683 520070.0 -448455.625 -2.67588356073555 -5.0226 -0.9977 2072271 Maybridge1_005270 CNC(=S)N/N=C/c1c(O)ccc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H13 compound treatment 762080.0 -117000.0 -0.67 1174040.0 244000.0 1.22 722200.0 -146947.8125 -0.808991782820584 847200.0 -121325.625 -0.723936165219169 -0.4908 -0.2784 2072272 Maybridge1_005271 COc1ccc(OC)c(/C=N/NC(=S)NCCc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H14 compound treatment 710940.0 -168000.0 -0.96 693300.0 -237000.0 -1.19 648160.0 -220987.8125 -1.21660419011679 814400.0 -154125.625 -0.919650023847046 -2.1407 -0.9925 2072273 Maybridge1_005272 COc1ccc(cc1)n2c(SCc3ccc(Br)cc3)nnc2c4ccco4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H15 compound treatment 696320.0 -183000.0 -1.04 807680.0 -123000.0 -0.61 715710.0 -153437.8125 -0.844721179408272 812170.0 -156355.625 -0.932956179479368 -1.7171 -0.9836 2072274 Maybridge1_005273 [O-][N+](=O)c1cccc(/C=N/NC(=O)N\N=C\c2cccc(c2)[N+](=O)[O-])c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H16 compound treatment 786360.0 -92500.0 -0.53 826200.0 -104000.0 -0.52 787270.0 -81877.8125 -0.450761915954513 854410.0 -114115.625 -0.680914917636639 -1.0907 -0.9884 2072275 Maybridge1_005274 FC(F)(F)c1cccc(NC(=S)NNC(=O)c2ccncc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H17 compound treatment 667800.0 -211000.0 -1.21 733080.0 -197000.0 -0.99 664340.0 -204807.8125 -1.12752843714471 813230.0 -155295.625 -0.926631280389565 -2.1234 -0.9946 2072276 Maybridge1_005275 O=C(N/N=C/c1cccs1)N/N=C/c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H18 compound treatment 752240.0 -127000.0 -0.72 796870.0 -134000.0 -0.67 853050.0 -16097.8125 -0.0886232861335482 868640.0 -99885.625 -0.596006130798996 -1.0379 -0.8992 2072277 Maybridge1_005276 CCCCCCCNC(=S)NNC(=O)c1ccncc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H19 compound treatment 744060.0 -135000.0 -0.77 736160.0 -194000.0 -0.97 728170.0 -140977.8125 -0.776125142199861 855520.0 -113005.625 -0.674291674250147 -1.596 -0.9909 2072278 Maybridge1_005277 CCOC(=O)N/N=C/c1ccc(OC)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H20 compound treatment 736590.0 -142000.0 -0.81 782270.0 -148000.0 -0.74 729410.0 -139737.8125 -0.769298570278639 859100.0 -109425.625 -0.652930222607226 -1.4879 -0.9969 2072279 Maybridge1_005278 CCOC(=O)NN=C1CCCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H21 compound treatment 545280.0 -334000.0 -1.91 552050.0 -378000.0 -1.89 451710.0 -417437.8125 -2.29812036263622 590010.0 -378515.625 -2.2585595585272 -4.1773 -0.9959 2072280 Maybridge1_005279 CCOC(=O)N/N=C/c1cc(Br)cc(Br)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H22 compound treatment 776320.0 -103000.0 -0.59 720260.0 -210000.0 -1.05 627220.0 -241927.8125 -1.33188517078646 760010.0 -208515.625 -1.24418894978516 -2.1065 -0.9645 2072281 Maybridge1_005280 COC(=O)Cc1csc2ccc(Cl)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H23 mock treatment 927090.0 48300.0 0.28 963480.0 33000.0 0.17 771050.0 -98097.8125 -0.540057880924048 1005920.0 37394.375 0.223127970189872 0.062 0.0929 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 H24 mock treatment 925280.0 46500.0 0.27 1026240.0 95800.0 0.48 818640.0 -50507.8125 -0.278060656947464 945670.0 -22855.625 -0.136376907320176 0.165 0.2623 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I01 compound treatment 779420.0 -99400.0 -0.57 897980.0 -32500.0 -0.16 1008710.0 139562.1875 0.768331701977297 1086690.0 118164.375 0.705073347061018 0.3716 0.31 2072282 Maybridge1_005281 Cc1ccc(cc1)S(=O)(=O)OCC2COc3ccccc3O2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I02 compound treatment 365820.0 -513000.0 -2.93 367550.0 -563000.0 -2.82 422880.0 -446267.8125 -2.45683815980464 469600.0 -498925.625 -2.97703229381326 -5.5899 -0.9974 1273865 Maybridge1_005282 O=C(NC1Cc2ccccc2C1)Nc3ccc(OCc4ccccc4)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I03 compound treatment 660530.0 -218000.0 -1.25 689000.0 -241000.0 -1.21 654160.0 -214987.8125 -1.18357239049797 821860.0 -146665.625 -0.875137054781071 -2.2567 -0.9915 2072283 Maybridge1_005283 COC(=O)c1ccc(CNC(=O)Nc2cccc(SC)c2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I04 compound treatment 443170.0 -436000.0 -2.49 474240.0 -456000.0 -2.28 567710.0 -301437.8125 -1.65950557000576 598210.0 -370315.625 -2.20963109387024 -4.3198 -0.9901 1930349 Maybridge1_005284 Cc1cc(C)n2nc(cc2n1)c3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I05 compound treatment 728210.0 -151000.0 -0.86 700320.0 -230000.0 -1.15 751950.0 -117197.8125 -0.645209109710616 833950.0 -134575.625 -0.802997403841711 -1.7298 -0.9783 2072284 Maybridge1_005285 Cc1ccc2nc(sc2c1)c3ccc(NS(=O)(=O)c4cccc5nonc45)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I06 compound treatment 723580.0 -155000.0 -0.89 785600.0 -145000.0 -0.72 787530.0 -81617.8125 -0.449330537971031 859710.0 -108815.625 -0.649290422187623 -1.355 -0.9741 1585869 Maybridge1_005286 Cc1ccc(cc1)S(=O)(=O)NC(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I07 compound treatment 735870.0 -143000.0 -0.82 808960.0 -121000.0 -0.61 751370.0 -117777.8125 -0.648402183673769 875330.0 -93195.625 -0.55608766390203 -1.3144 -0.9891 2072285 Maybridge1_005287 COc1cccc(NC(=O)NCCSCc2ccco2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I08 compound treatment 791060.0 -87800.0 -0.5 742200.0 -188000.0 -0.94 733050.0 -136097.8125 -0.74925927850989 834890.0 -133635.625 -0.797388531063961 -1.4948 -0.9782 1175274 Maybridge1_005288 Brc1cncc(c1)C(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I09 compound treatment 616800.0 -262000.0 -1.5 553920.0 -377000.0 -1.88 569920.0 -299227.8125 -1.64733885714616 663700.0 -304825.625 -1.8188597340672 -3.4231 -0.9961 1343669 Maybridge1_005289 NNC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I10 compound treatment 749230.0 -130000.0 -0.74 786660.0 -144000.0 -0.72 758030.0 -111117.8125 -0.611736886096882 826950.0 -141575.625 -0.844765605378148 -1.458 -0.9936 1273246 Maybridge1_005290 O=C(NC1Cc2ccccc2C1)C3CC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I11 compound treatment 523200.0 -356000.0 -2.03 618760.0 -312000.0 -1.56 555000.0 -314147.8125 -1.72947793219829 660580.0 -307945.625 -1.83747641818058 -3.5787 -0.9954 2072286 Maybridge1_005291 Nc1nc(cc(n1)C(F)(F)F)c2ccc3CCCc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I12 compound treatment 744480.0 -134000.0 -0.77 611080.0 -319000.0 -1.6 571610.0 -297537.8125 -1.63803490025353 778730.0 -189795.625 -1.13248884510486 -2.5677 -0.9632 1126364 Maybridge1_005292 Clc1ccc(s1)S(=O)(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I13 compound treatment 537620.0 -341000.0 -1.95 657760.0 -273000.0 -1.36 591200.0 -277947.8125 -1.53018607449809 687930.0 -280595.625 -1.67428208789179 -3.2587 -0.9914 2072287 Maybridge1_005293 FC(F)(F)c1cc(n[nH]1)c2ccc3OCOc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I14 compound treatment 742020.0 -137000.0 -0.78 751410.0 -179000.0 -0.9 754190.0 -114957.8125 -0.632877237852924 975940.0 7414.375 0.0442407298952458 -1.1328 -0.8408 1287710 Maybridge1_005294 O=C(CSCc1ccccc1)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I15 compound treatment 750580.0 -128000.0 -0.73 737470.0 -193000.0 -0.97 748550.0 -120597.8125 -0.663927129494613 892840.0 -75685.625 -0.4516074912016 -1.4067 -0.9677 2072288 Maybridge1_005295 COc1ccc(Cl)cc1S(=O)(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I16 compound treatment 874370.0 -4450.0 -0.03 813320.0 -117000.0 -0.59 743550.0 -125597.8125 -0.69145362917696 815200.0 -153325.625 -0.914876515100024 -1.1088 -0.8609 1566045 Maybridge1_005296 Clc1ccc(SCC(=O)NC2Cc3ccccc3C2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I17 compound treatment 717610.0 -161000.0 -0.92 792740.0 -138000.0 -0.69 783140.0 -86007.8125 -0.473498804692132 859310.0 -109215.625 -0.651677176561133 -1.3674 -0.9739 2072289 Maybridge1_005297 FC(F)(F)c1cc(nc2cc(nn12)c3ccccc3)c4ccc5OCOc5c4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I18 compound treatment 722240.0 -157000.0 -0.89 741570.0 -189000.0 -0.94 740660.0 -128487.8125 -0.707363945993357 817500.0 -151025.625 -0.901152677452338 -1.7239 -0.9944 2072290 Maybridge1_005298 FC(F)(F)c1cc(N2CCN(Cc3ccccc3)CC2)c4ccccc4n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I19 compound treatment 635070.0 -244000.0 -1.39 718570.0 -212000.0 -1.06 660440.0 -208707.8125 -1.14899910689694 778000.0 -190525.625 -1.13684467183652 -2.369 -0.9945 2072291 Maybridge1_005299 COc1ccc(cc1)c2cc(n3nc(C)cc3n2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I20 compound treatment 544480.0 -334000.0 -1.91 504260.0 -426000.0 -2.13 562720.0 -306427.8125 -1.68697701668874 614240.0 -354285.625 -2.11398191235179 -3.9213 -0.9958 2072292 Maybridge1_005300 Oc1ccc(cc1)n2nnnc2SCc3c(F)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I21 compound treatment 810160.0 -68700.0 -0.39 772080.0 -158000.0 -0.79 768060.0 -101087.8125 -0.556518727734092 859300.0 -109225.625 -0.651736845420471 -1.1963 -0.9717 2072293 Maybridge1_005301 CC(C)(C)c1cc2nc(cc(n2n1)C(F)(F)F)c3cccc(c3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I22 compound treatment 681990.0 -197000.0 -1.12 921370.0 -9090.0 -0.05 767400.0 -101747.8125 -0.560152225692162 873300.0 -95225.625 -0.568200442347597 -1.1491 -0.833 1165427 Maybridge1_005302 NNC(=O)CSc1ccnc2cc(Cl)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I23 mock treatment 767680.0 -111000.0 -0.63 865600.0 -64900.0 -0.32 843400.0 -25747.8125 -0.141749430520479 913810.0 -54715.625 -0.326481893170302 -0.7138 -0.8957 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 I24 mock treatment 1019680.0 141000.0 0.8 1058400.0 128000.0 0.64 843560.0 -25587.8125 -0.140868582530644 899690.0 -68835.625 -0.410734322555229 0.4465 0.4001 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J01 compound treatment 726400.0 -152000.0 -0.87 710970.0 -219000.0 -1.1 761440.0 -107707.8125 -0.592963813313521 851300.0 -117225.625 -0.699471932890685 -1.6305 -0.9737 2072294 Maybridge1_005303 Brc1ccc(s1)S(=O)(=O)Nc2ccc3CS(=O)(=O)Cc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J02 compound treatment 719570.0 -159000.0 -0.91 747630.0 -183000.0 -0.91 714190.0 -154957.8125 -0.853089235311705 845550.0 -122975.625 -0.733781527009901 -1.7055 -0.9964 2072295 Maybridge1_005304 CCOC(=O)N/N=C/c1ccc(OC)c(O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J03 compound treatment 600000.0 -279000.0 -1.59 538460.0 -392000.0 -1.96 555720.0 -313427.8125 -1.72551411624403 639200.0 -329325.625 -1.96504843944473 -3.622 -0.9962 2072296 Maybridge1_005305 CCOc1ccc(/C=N/NS(=O)(=O)c2ccc(C)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J04 compound treatment 755170.0 -124000.0 -0.71 812340.0 -118000.0 -0.59 733480.0 -135667.8125 -0.746891999537208 806300.0 -162225.625 -0.967981799910637 -1.506 -0.9839 1019747 Maybridge1_005306 [O-][N+](=O)c1ccc(cc1)C(=O)Nc2nccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J05 compound treatment 660870.0 -218000.0 -1.25 713250.0 -217000.0 -1.09 673760.0 -195387.8125 -1.07566851174317 780750.0 -187775.625 -1.12043573551863 -2.2638 -0.9982 1467929 Maybridge1_005307 CC(C)(C)c1ccc(s1)C(=O)NC(=O)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J06 compound treatment 766180.0 -113000.0 -0.64 724040.0 -206000.0 -1.03 750730.0 -118417.8125 -0.651925575633109 799600.0 -168925.625 -1.00795993566694 -1.6679 -0.9759 2072297 Maybridge1_005308 COc1ccc(/C=N/NC(=S)NC2CC3CCC2C3)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J07 compound treatment 626110.0 -253000.0 -1.44 656320.0 -274000.0 -1.37 671720.0 -197427.8125 -1.08689932361357 753860.0 -214665.625 -1.28088529827789 -2.5913 -0.9947 1530152 Maybridge1_005309 c1sc(nc1c2ccccc2)c3ccncc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J08 compound treatment 708060.0 -171000.0 -0.98 678050.0 -252000.0 -1.26 676570.0 -192577.8125 -1.06019861892169 728640.0 -239885.625 -1.43137016152774 -2.3647 -0.9889 2072298 Maybridge1_005310 COc1ccc(cc1)c2nc(cs2)c3ccc(Br)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J09 compound treatment 687970.0 -191000.0 -1.09 676340.0 -254000.0 -1.27 630940.0 -238207.8125 -1.31140545502279 759240.0 -209285.625 -1.24878345195417 -2.4607 -0.9977 1561476 Maybridge1_005311 COc1ccccc1Nc2nnns2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J10 compound treatment 700880.0 -178000.0 -1.02 729130.0 -201000.0 -1.01 759770.0 -109377.8125 -0.602157664207425 830030.0 -138495.625 -0.826387596702116 -1.726 -0.9815 2072299 Maybridge1_005312 C/C(=N\NC(=O)N/N=C(\C)/c1ccc(C)cc1)/c2ccc(C)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J11 compound treatment 548960.0 -330000.0 -1.88 576980.0 -353000.0 -1.77 604870.0 -264277.8125 -1.45492862436655 614330.0 -354195.625 -2.11344489261775 -3.6103 -0.9915 2072300 Maybridge1_005313 Fc1ccc(cc1)c2csc(Nc3ccccc3Cl)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J12 compound treatment 723760.0 -155000.0 -0.89 752060.0 -178000.0 -0.89 761870.0 -107277.8125 -0.590596534340839 917600.0 -50925.625 -0.303867395481288 -1.3363 -0.9397 2072301 Maybridge1_005314 CNC(=S)N/N=C/c1ccccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J13 compound treatment 1023200.0 144000.0 0.82 944800.0 14300.0 0.07 713830.0 -155317.8125 -0.855071143288834 1110670.0 142144.375 0.848159271752983 0.4448 0.3043 2072302 Maybridge1_005315 COc1cc(/C=N/NC(=S)NCCc2ccccc2)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J14 compound treatment 687430.0 -191000.0 -1.09 700250.0 -230000.0 -1.15 655070.0 -214077.8125 -1.17856256755578 813600.0 -154925.625 -0.924423532594067 -2.1739 -0.9959 2072303 Maybridge1_005316 COc1cc(cc(OC)c1OC)C(=O)NNC(=S)Nc2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J15 compound treatment 387470.0 -491000.0 -2.81 451900.0 -479000.0 -2.39 401880.0 -467267.8125 -2.5724494584705 506400.0 -462125.625 -2.75745089145028 -5.2651 -0.9981 2072304 Maybridge1_005317 Oc1c(Cl)cc(Cl)cc1/C=N/NC(=O)N\N=C\c2cc(Cl)cc(Cl)c2O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J16 compound treatment 733050.0 -146000.0 -0.83 833280.0 -97200.0 -0.49 725440.0 -143707.8125 -0.791154611026423 924910.0 -43615.625 -0.26024945930538 -1.1851 -0.9301 1083192 Maybridge1_005318 Clc1cccc(NC(=S)NNC(=O)c2ccncc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J17 compound treatment 789830.0 -89000.0 -0.51 739790.0 -191000.0 -0.95 720060.0 -149087.8125 -0.820773124684629 868050.0 -100475.625 -0.599526593499925 -1.4412 -0.9714 2072305 Maybridge1_005319 O=C(N/N=C/c1cccc2ccccc12)N/N=C/c3cccc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J18 compound treatment 946430.0 67600.0 0.39 791240.0 -139000.0 -0.7 752090.0 -117057.8125 -0.64443836771951 1043440.0 74914.375 0.447005530425174 -0.2538 -0.2271 2072306 Maybridge1_005320 CCOC(=O)N/N=C(\C)/c1cccc(c1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J19 compound treatment 733560.0 -145000.0 -0.83 780230.0 -150000.0 -0.75 748030.0 -121117.8125 -0.666789885461577 881940.0 -86585.625 -0.516646547879766 -1.3823 -0.9862 2072307 Maybridge1_005321 CCOC(=O)NNC(=S)Nc1cccc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J20 compound treatment 723460.0 -155000.0 -0.89 795580.0 -135000.0 -0.67 735620.0 -133527.8125 -0.735110657673163 886030.0 -82495.625 -0.492241984410619 -1.3947 -0.98 2072308 Maybridge1_005322 Brc1ccc2NC(=O)/C(=N\NC(=O)c3ccco3)/c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J21 compound treatment 679040.0 -200000.0 -1.14 756090.0 -174000.0 -0.87 708660.0 -160487.8125 -0.883533543960382 776640.0 -191885.625 -1.14495963670645 -2.0209 -0.9915 2072309 Maybridge1_005323 CCOC(=O)N/N=C/c1cc(Br)ccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J22 compound treatment 793810.0 -85000.0 -0.49 762560.0 -168000.0 -0.84 692240.0 -176907.8125 -0.973930568917211 878510.0 -90015.625 -0.53711296663262 -1.4182 -0.961 1371563 Maybridge1_005324 Cc1c(CC(=S)N2CCOCC2)sc3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J23 mock treatment 862010.0 -16800.0 -0.1 857070.0 -73400.0 -0.37 790000.0 -79147.8125 -0.435732447127951 927160.0 -41365.625 -0.246823965954383 -0.5728 -0.9117 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 J24 mock treatment 1001960.0 123000.0 0.7 1100200.0 170000.0 0.85 851680.0 -17467.8125 -0.0961655470465114 894120.0 -74405.625 -0.443969877206366 0.5061 0.4244 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K01 compound treatment 851040.0 -27800.0 -0.16 904280.0 -26200.0 -0.13 1042290.0 173142.1875 0.953199673843943 925410.0 -43115.625 -0.257266016338492 0.2031 0.2014 2072310 Maybridge1_005325 CC(C)Sc1c(Cl)cccc1NC(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K02 compound treatment 723540.0 -155000.0 -0.89 773000.0 -157000.0 -0.79 793760.0 -75387.8125 -0.415032519366826 894470.0 -74055.625 -0.441881467129544 -1.2657 -0.9502 2072311 Maybridge1_005326 CCCCNC(=O)NC1Cc2ccccc2C1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K03 compound treatment 665990.0 -213000.0 -1.22 768870.0 -162000.0 -0.81 602490.0 -266657.8125 -1.46803123821535 787130.0 -181395.625 -1.08236700326114 -2.2872 -0.979 2072312 Maybridge1_005327 O=C(NCCSCc1ccco1)Nc2ccc(OCc3ccccc3)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K04 compound treatment 733210.0 -146000.0 -0.83 735540.0 -195000.0 -0.97 739100.0 -130047.8125 -0.71595221389425 860530.0 -107995.625 -0.644397575721926 -1.5835 -0.9877 1232037 Maybridge1_005328 Cc1c(Cl)cccc1NC(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K05 compound treatment 751760.0 -127000.0 -0.73 817760.0 -113000.0 -0.56 798110.0 -71037.8125 -0.391084464643183 914510.0 -54015.625 -0.322305073016658 -1.0014 -0.9542 2072313 Maybridge1_005329 Cc1c(Cl)cccc1NC(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K06 compound treatment 733810.0 -145000.0 -0.83 724160.0 -206000.0 -1.03 698750.0 -170397.8125 -0.938091066330795 802840.0 -165685.625 -0.988627225241505 -1.8935 -0.9968 2072314 Maybridge1_005330 FC(F)(F)Oc1ccc(NC(=O)NC2Cc3ccccc3C2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K07 compound treatment 762340.0 -116000.0 -0.67 773280.0 -157000.0 -0.79 753450.0 -115697.8125 -0.636951159805912 911890.0 -56635.625 -0.337938314163153 -1.2132 -0.965 2072315 Maybridge1_005331 O=C(NCCSCc1ccco1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K08 compound treatment 704170.0 -175000.0 -1.0 735390.0 -195000.0 -0.98 754480.0 -114667.8125 -0.631280700871348 804220.0 -164305.625 -0.980392922652893 -1.7925 -0.9857 1478124 Maybridge1_005332 Cc1occ(c1C(=O)NC2Cc3ccccc3C2)c4cc(F)ccc4Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K09 compound treatment 727460.0 -151000.0 -0.86 747300.0 -183000.0 -0.92 731440.0 -137707.8125 -0.758122811407606 857720.0 -110805.625 -0.661164525195838 -1.6 -0.9925 1022545 Maybridge1_005333 OC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K10 compound treatment 712710.0 -166000.0 -0.95 759520.0 -171000.0 -0.85 845340.0 -23807.8125 -0.131069148643728 854450.0 -114075.625 -0.680676242199288 -1.3078 -0.8999 1514678 Maybridge1_005334 CC(=O)Nc1ccc(cc1)S(=O)(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K11 compound treatment 553010.0 -326000.0 -1.86 509640.0 -421000.0 -2.1 530850.0 -338297.8125 -1.86243092566403 549070.0 -419455.625 -2.50284386865602 -4.1656 -0.9922 2072316 Maybridge1_005335 CC(C)(C)c1cc2c(CCC2(C)C)c(c1)c3cc(nc(N)n3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K12 compound treatment 595290.0 -284000.0 -1.62 604130.0 -326000.0 -1.63 682850.0 -186297.8125 -1.02562533532066 714340.0 -254185.625 -1.51669663038074 -2.8971 -0.9856 1395391 Maybridge1_005336 Clc1cccc(c1)S(=O)(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K13 compound treatment 233280.0 -646000.0 -3.69 315450.0 -615000.0 -3.08 566830.0 -302317.8125 -1.66435023394985 498010.0 -470515.625 -2.80751306443466 -5.6178 -0.9675 2072317 Maybridge1_005337 CC(C)(C)c1cc2c(CCC2(C)C)c(c1)c3cc([nH]n3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K14 compound treatment 787310.0 -91500.0 -0.52 728170.0 -202000.0 -1.01 745610.0 -123537.8125 -0.680112711307833 842240.0 -126285.625 -0.753531919450702 -1.4841 -0.9728 1326753 Maybridge1_005338 CCn1nnnc1SCC(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K15 compound treatment 634510.0 -244000.0 -1.4 715360.0 -215000.0 -1.08 657280.0 -211867.8125 -1.16639585469619 822730.0 -145795.625 -0.869945864018686 -2.2539 -0.9863 2072318 Maybridge1_005339 FC(F)(F)c1ccc(Cl)c(c1)S(=O)(=O)NCCSCc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K16 compound treatment 717850.0 -161000.0 -0.92 740350.0 -190000.0 -0.95 721210.0 -147937.8125 -0.814442029757689 813760.0 -154765.625 -0.923468830844663 -1.8041 -0.9983 1589432 Maybridge1_005340 O=C(CSc1cccs1)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K17 compound treatment 738240.0 -141000.0 -0.8 810080.0 -120000.0 -0.6 718400.0 -150747.8125 -0.829911922579168 879460.0 -89065.625 -0.531444424995532 -1.3833 -0.9834 2072319 Maybridge1_005341 O=C(NCCSCc1ccco1)C2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K18 compound treatment 746400.0 -132000.0 -0.76 777370.0 -153000.0 -0.77 767890.0 -101257.8125 -0.557454628723292 883100.0 -85425.625 -0.509724960196585 -1.2947 -0.9846 2072320 Maybridge1_005342 Sc1nnc(c2ccc3ncccc3c2)n1CC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K19 compound treatment 739940.0 -139000.0 -0.79 740890.0 -190000.0 -0.95 725930.0 -143217.8125 -0.788457014057553 919620.0 -48905.625 -0.291814285895059 -1.4109 -0.9437 2072321 Maybridge1_005343 CC(C)(C)OC(=O)NCC(=O)NNC(=S)NCc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K20 compound treatment 605330.0 -273000.0 -1.56 646520.0 -284000.0 -1.42 666270.0 -202877.8125 -1.11690320826732 706820.0 -261705.625 -1.56156761260275 -2.8305 -0.9919 2072322 Maybridge1_005344 CSc1nccc(n1)c2ccc(s2)S(=O)(=O)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K21 compound treatment 754180.0 -125000.0 -0.71 721960.0 -208000.0 -1.04 697960.0 -171187.8125 -0.942440253280605 855370.0 -113155.625 -0.675186707140213 -1.6862 -0.9837 2072323 Maybridge1_005345 Cc1ccc2[nH]c(SCC(=O)NCCSCc3ccco3)nc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K22 compound treatment 789490.0 -89300.0 -0.51 874840.0 -55600.0 -0.28 738730.0 -130417.8125 -0.717989174870743 860260.0 -108265.625 -0.646008634924045 -1.0762 -0.9548 2072324 Maybridge1_005346 COc1ccc(cc1)c2ccnc(SCc3cccc(c3)[N+](=O)[O-])n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K23 mock treatment 782880.0 -95900.0 -0.55 875360.0 -55100.0 -0.28 812560.0 -56587.8125 -0.311532880561199 908270.0 -60255.625 -0.359538441243425 -0.7474 -0.9627 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 K24 mock treatment 968550.0 89700.0 0.51 993190.0 62700.0 0.31 848100.0 -21047.8125 -0.115874520819072 898650.0 -69875.625 -0.416939883926357 0.1468 0.1982 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L01 compound treatment 815970.0 -62900.0 -0.36 967450.0 37000.0 0.19 1058530.0 189382.1875 1.04260574481221 947680.0 -20845.625 -0.124383466593284 0.3721 0.3308 2072325 Maybridge1_005347 COC(=O)/C=C(/c1ccccc1)\n2cnc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L02 compound treatment 805760.0 -73100.0 -0.42 744060.0 -186000.0 -0.93 753390.0 -115757.8125 -0.6372814778021 835160.0 -133365.625 -0.795777471861841 -1.3914 -0.9641 1920895 Maybridge1_005348 CCOC(=O)N/N=C/c1c[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L03 compound treatment 819040.0 -59800.0 -0.34 758300.0 -172000.0 -0.86 785610.0 -83537.8125 -0.459900713849052 892100.0 -76425.625 -0.456022986792595 -1.0592 -0.9372 1004905 Maybridge1_005349 COc1cccc(NC(=O)C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L04 compound treatment 692590.0 -186000.0 -1.06 699910.0 -231000.0 -1.15 663230.0 -205917.8125 -1.13363932007419 759450.0 -209075.625 -1.24753040590808 -2.2991 -0.9984 1061299 Maybridge1_005350 Clc1ccc(cc1)C(=O)Nc2nccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L05 compound treatment 752800.0 -126000.0 -0.72 698280.0 -232000.0 -1.16 726130.0 -143017.8125 -0.787355954070259 910420.0 -58105.625 -0.346709636485805 -1.5076 -0.9337 2072326 Maybridge1_005351 FC(F)(F)c1cc(NC(=O)NC(=O)c2ccc(s2)c3ccc(Cl)cc3)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L06 compound treatment 705380.0 -173000.0 -0.99 745230.0 -185000.0 -0.93 786950.0 -82197.8125 -0.452523611934183 828960.0 -139565.625 -0.832772164651257 -1.6013 -0.9677 2072327 Maybridge1_005352 COc1cc(/C=N/NC(=S)NC2CC3CCC2C3)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L07 compound treatment 669190.0 -210000.0 -1.2 655950.0 -275000.0 -1.37 695730.0 -173417.8125 -0.954717072138932 785710.0 -182815.625 -1.0908399812871 -2.308 -0.9913 2072328 Maybridge1_005353 Brc1ccc(cc1)c2csc(n2)c3ccncc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L08 compound treatment 537840.0 -341000.0 -1.95 513350.0 -417000.0 -2.09 545220.0 -323927.8125 -1.78331976557696 554890.0 -413635.625 -2.46811659252144 -4.1427 -0.9926 2072329 Maybridge1_005354 COc1ccc(cc1)c2nc(cs2)c3cccc(c3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L09 compound treatment 750300.0 -129000.0 -0.73 724180.0 -206000.0 -1.03 646570.0 -222577.8125 -1.22535761701577 847420.0 -121105.625 -0.722623450313738 -1.8569 -0.975 2072330 Maybridge1_005355 c1sc(nc1c2ccc(cc2)c3ccccc3)c4cccnc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L10 compound treatment 613410.0 -265000.0 -1.52 650790.0 -280000.0 -1.4 598730.0 -270417.8125 -1.48873116597648 826820.0 -141705.625 -0.845541300549539 -2.6246 -0.979 2072331 Maybridge1_005356 CNC(=S)N/N=C/c1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L11 compound treatment 817120.0 -61700.0 -0.35 762480.0 -168000.0 -0.84 774990.0 -94157.8125 -0.518366999174359 923280.0 -45245.625 -0.269975483377436 -0.9905 -0.915 2072332 Maybridge1_005357 Clc1ccccc1Nc2nc(cs2)c3ccc(cc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L12 compound treatment 664660.0 -214000.0 -1.22 725300.0 -205000.0 -1.03 869440.0 292.1875 0.00160857982518719 798630.0 -169895.625 -1.0137478150227 -1.6308 -0.8622 2072333 Maybridge1_005358 CNC(=S)N/N=C/c1ccc(OC)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L13 compound treatment 901290.0 22500.0 0.13 974420.0 44000.0 0.22 899530.0 30382.1875 0.167263054913555 897250.0 -71275.625 -0.425293524233644 0.0451 0.0862 2072334 Maybridge1_005359 CCOc1ccccc1/C=N/NC(=O)N\N=C\c2ccccc2OCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L14 compound treatment 672280.0 -207000.0 -1.18 660440.0 -270000.0 -1.35 632230.0 -236917.8125 -1.30430361810475 704800.0 -263725.625 -1.57362072218897 -2.7042 -0.9945 1125175 Maybridge1_005360 COc1cc(cc(OC)c1OC)c2n[nH]c(=S)n2c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L15 compound treatment 646400.0 -232000.0 -1.33 835860.0 -94600.0 -0.47 735170.0 -133977.8125 -0.737588042644575 733000.0 -235525.625 -1.40535453885647 -1.9719 -0.929 2072335 Maybridge1_005361 Oc1ccc(Br)cc1/C=N/NC(=O)N\N=C\c2cc(Br)ccc2O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L16 compound treatment 671150.0 -208000.0 -1.19 740770.0 -190000.0 -0.95 724090.0 -145057.8125 -0.798586765940657 773880.0 -194645.625 -1.16142824188368 -2.0475 -0.9881 1472644 Maybridge1_005362 O=S(=O)(N1CCCCC1)c2ccc(cc2)n3c(n[nH]c3=S)c4ccncc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L17 compound treatment 470120.0 -409000.0 -2.33 451400.0 -479000.0 -2.4 453200.0 -415947.8125 -2.28991746573088 483540.0 -484985.625 -2.89385390389641 -4.9573 -0.9952 2072336 Maybridge1_005363 COc1cc(/C=N/NC(=O)N\N=C\c2ccc(O)c(OC)c2)ccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L18 compound treatment 821830.0 -57000.0 -0.33 902930.0 -27500.0 -0.14 780870.0 -88277.8125 -0.485995835547918 903480.0 -65045.625 -0.388119824866215 -0.6687 -0.9347 1014806 Maybridge1_005364 CC12NC(=O)NC2(C)NC(=O)N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L19 compound treatment 822180.0 -56600.0 -0.32 780000.0 -150000.0 -0.75 784960.0 -84187.8125 -0.463479158807758 974320.0 5794.375 0.0345743746825275 -0.7525 -0.799 2072337 Maybridge1_005365 CCOC(=O)N/N=C/c1ccc(OC)c(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L20 compound treatment 702450.0 -176000.0 -1.01 777610.0 -153000.0 -0.76 685570.0 -183577.8125 -1.01065091949346 739680.0 -228845.625 -1.36549574081884 -2.0741 -0.9793 1090220 Maybridge1_005366 Cc1csc2ccc(Cl)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L21 compound treatment 757920.0 -121000.0 -0.69 786820.0 -144000.0 -0.72 771110.0 -98037.8125 -0.53972756292786 911160.0 -57365.625 -0.34229414089481 -1.1455 -0.9676 2072338 Maybridge1_005367 CCOC(=O)N/N=C/c1ccc(O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L22 compound treatment 762400.0 -116000.0 -0.67 725180.0 -205000.0 -1.03 785960.0 -83187.8125 -0.457973858871288 934270.0 -34255.625 -0.20439940696523 -1.1771 -0.8903 1250303 Maybridge1_005368 Cc1c(CC(=O)O)sc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L23 mock treatment 760100.0 -119000.0 -0.68 873660.0 -56800.0 -0.28 844890.0 -24257.8125 -0.133546533615139 895610.0 -72915.625 -0.435079217165038 -0.7654 -0.8852 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 L24 mock treatment 880430.0 1610.0 0.01 877630.0 -52800.0 -0.26 787200.0 -81947.8125 -0.451147286950066 987240.0 18714.375 0.111666540946923 -0.2973 -0.5559 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M01 compound treatment 733790.0 -145000.0 -0.83 750420.0 -180000.0 -0.9 882160.0 13012.1875 0.0716359950170794 935700.0 -32825.625 -0.195866760079929 -0.9266 -0.7465 1525913 Maybridge1_005369 CC(C)Sc1c(Cl)cccc1NC(=O)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M02 compound treatment 547320.0 -332000.0 -1.89 504030.0 -426000.0 -2.13 510450.0 -358697.8125 -1.974739044368 506050.0 -462475.625 -2.7595393015271 -4.3804 -0.9882 1302742 Maybridge1_005370 CC(C)(C)c1ccc(NC(=O)NC2Cc3ccccc3C2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M03 compound treatment 690900.0 -188000.0 -1.07 788370.0 -142000.0 -0.71 749840.0 -119307.8125 -0.656825292576567 772490.0 -196035.625 -1.16972221333163 -1.8054 -0.971 2072339 Maybridge1_005371 O=C(NCCSCc1ccco1)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M04 compound treatment 587040.0 -292000.0 -1.67 558400.0 -372000.0 -1.86 517180.0 -351967.8125 -1.93768837579556 630790.0 -337735.625 -2.01522995014779 -3.7403 -0.9976 1537203 Maybridge1_005372 Clc1cccc(NC(=O)NC2Cc3ccccc3C2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M05 compound treatment 688070.0 -191000.0 -1.09 730990.0 -199000.0 -1.0 693120.0 -176027.8125 -0.969085904973118 810460.0 -158065.625 -0.943159554426126 -1.9998 -0.9985 2072340 Maybridge1_005373 Clc1cccc(NC(=O)NCCSCc2ccco2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M06 compound treatment 672880.0 -206000.0 -1.18 798420.0 -132000.0 -0.66 721680.0 -147467.8125 -0.811854538787549 777010.0 -191515.625 -1.14275188891096 -1.8957 -0.9744 2072341 Maybridge1_005374 Cn1c(SCc2ccc(Cl)cc2)nnc1c3ccc4ncccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M07 compound treatment 703060.0 -176000.0 -1.0 636190.0 -294000.0 -1.47 735300.0 -133847.8125 -0.736872353652834 836640.0 -131885.625 -0.786946480679852 -1.9998 -0.9603 2072342 Maybridge1_005375 FC(F)(F)Oc1ccc(NC(=O)NCCSCc2ccco2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M08 compound treatment 583630.0 -295000.0 -1.69 593320.0 -337000.0 -1.69 574250.0 -294897.8125 -1.62350090842125 617800.0 -350725.625 -2.09273979842755 -3.5444 -0.9945 1379425 Maybridge1_005376 Cc1onc(c1C(=O)NC2Cc3ccccc3C2)c4ccccc4Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M09 compound treatment 741000.0 -138000.0 -0.79 716280.0 -214000.0 -1.07 752030.0 -117117.8125 -0.644768685715699 867870.0 -100655.625 -0.600600632968004 -1.552 -0.973 2072343 Maybridge1_005377 Cn1c(S)nnc1c2ccc3ncccc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M10 compound treatment 672990.0 -206000.0 -1.18 832740.0 -97700.0 -0.49 652330.0 -216817.8125 -1.19364708938171 771700.0 -196825.625 -1.17443605321931 -2.0163 -0.9585 1211239 Maybridge1_005378 O=S(=O)(NC1Cc2ccccc2C1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M11 compound treatment 617170.0 -262000.0 -1.49 770940.0 -160000.0 -0.8 687520.0 -181627.8125 -0.999915584617347 703900.0 -264625.625 -1.57899091952937 -2.4357 -0.9655 2072344 Maybridge1_005379 FC(F)(F)C(=O)CC(=O)c1ccc2OCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M12 compound treatment 810290.0 -68500.0 -0.39 729050.0 -201000.0 -1.01 729280.0 -139867.8125 -0.77001425927038 953220.0 -15305.625 -0.0913269185201613 -1.1301 -0.8496 1477772 Maybridge1_005380 Fc1cccc(Cl)c1CSCC(=O)NC2Cc3ccccc3C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M13 compound treatment 733150.0 -146000.0 -0.83 825370.0 -105000.0 -0.53 817130.0 -52017.8125 -0.286373659851533 843200.0 -125325.625 -0.747803708954276 -1.196 -0.9426 2072345 Maybridge1_005381 Nc1nc(cc(n1)C(F)(F)F)c2ccc3OCOc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M14 compound treatment 745030.0 -134000.0 -0.76 744740.0 -186000.0 -0.93 685930.0 -183217.8125 -1.00866901151633 869760.0 -98765.625 -0.589323218553166 -1.6456 -0.9814 2072346 Maybridge1_005382 CCCc1cc(O)nc(SCC(=O)NC2Cc3ccccc3C2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M15 compound treatment 773300.0 -106000.0 -0.6 736910.0 -194000.0 -0.97 735580.0 -133567.8125 -0.735330869670622 832590.0 -135935.625 -0.811112368711647 -1.5586 -0.986 2072347 Maybridge1_005383 Cn1c(SCc2ccccc2)nnc1c3ccc4ncccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M16 compound treatment 866180.0 -12600.0 -0.07 866720.0 -63700.0 -0.32 734640.0 -134507.8125 -0.740505851610904 878360.0 -90165.625 -0.538007999522687 -0.8348 -0.8589 1244204 Maybridge1_005384 O=C(Cn1nnc2ccccc12)NC3Cc4ccccc4C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M17 compound treatment 778400.0 -100000.0 -0.57 810240.0 -120000.0 -0.6 814370.0 -54777.8125 -0.301568287676189 923690.0 -44835.625 -0.267529060144588 -0.872 -0.9441 2072348 Maybridge1_005385 Oc1ccc(cc1)n2nnnc2SCC(=O)NCCSCc3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M18 compound treatment 739290.0 -140000.0 -0.8 776990.0 -153000.0 -0.77 759260.0 -109887.8125 -0.604965367175024 829650.0 -138875.625 -0.828655013356951 -1.4991 -0.9934 2072349 Maybridge1_005386 OCCN1CCN(CC1)c2cc(nc3c(F)cccc23)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M19 compound treatment 771680.0 -107000.0 -0.61 817600.0 -113000.0 -0.56 922530.0 53382.1875 0.293884953452354 928070.0 -40455.625 -0.241394099754646 -0.562 -0.614 2072350 Maybridge1_005387 CC(C)(C)OC(=O)NCC(=O)NNC(=S)Nc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M20 compound treatment 692000.0 -187000.0 -1.07 739720.0 -191000.0 -0.95 683930.0 -185217.8125 -1.01967961138927 859800.0 -108725.625 -0.648753402453583 -1.8448 -0.9847 2072351 Maybridge1_005388 CCOC(=O)c1ccc2nc(cc(N3CCOCC3)c2c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M21 compound treatment 777210.0 -102000.0 -0.58 786460.0 -144000.0 -0.72 762400.0 -106747.8125 -0.58767872537451 866970.0 -101555.625 -0.605970830308403 -1.2472 -0.9959 2072352 Maybridge1_005389 O=C(CSc1nnc(SCC(=O)NCCSCc2ccco2)s1)NCCSCc3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M22 compound treatment 727050.0 -152000.0 -0.87 734370.0 -196000.0 -0.98 739710.0 -129437.8125 -0.712593980933003 828960.0 -139565.625 -0.832772164651257 -1.6966 -0.9937 1205842 Maybridge1_005390 COc1ccc(cc1)c2ccnc(SCC(=O)Nc3ccc(cc3)C(C)C)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M23 mock treatment 822830.0 -56000.0 -0.32 794160.0 -136000.0 -0.68 869980.0 832.1875 0.00458144179088073 881640.0 -86885.625 -0.518436613659899 -0.7577 -0.8288 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 M24 mock treatment 818200.0 -60600.0 -0.35 863550.0 -66900.0 -0.33 859400.0 -9747.8125 -0.0536646315369668 907790.0 -60735.625 -0.362402546491638 -0.5485 -0.9065 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N01 compound treatment 786080.0 -92700.0 -0.53 777460.0 -153000.0 -0.77 974990.0 105842.1875 0.582692988119545 866800.0 -101725.625 -0.606985200917146 -0.6597 -0.5258 1080875 Maybridge1_005391 OC(=O)Cc1noc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N02 compound treatment 796060.0 -82800.0 -0.47 778130.0 -152000.0 -0.76 957820.0 88672.1875 0.488166988210363 858310.0 -110215.625 -0.65764406249491 -0.7021 -0.5781 2072353 Maybridge1_005392 CCOC(=O)N/N=C/c1cccc(O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N03 compound treatment 817850.0 -61000.0 -0.35 786050.0 -144000.0 -0.72 811360.0 -57787.8125 -0.318139240484962 874400.0 -94125.625 -0.561636867820443 -0.9752 -0.9473 1008357 Maybridge1_005393 CC(=O)Nc1cccc(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N04 compound treatment 819290.0 -59500.0 -0.34 932040.0 1580.0 0.01 768600.0 -100547.8125 -0.553545865768399 902560.0 -65965.625 -0.39360935992529 -0.6397 -0.842 2072354 Maybridge1_005394 Cc1ccccc1C(=O)Nc2nccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N05 compound treatment 816110.0 -62700.0 -0.36 813990.0 -116000.0 -0.58 786320.0 -82827.8125 -0.455991950894159 956390.0 -12135.625 -0.0724118901100891 -0.7346 -0.8903 2072355 Maybridge1_005395 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nnc(o2)c3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N06 compound treatment 783210.0 -95600.0 -0.55 812960.0 -117000.0 -0.59 802720.0 -66427.8125 -0.365705031936059 946400.0 -22125.625 -0.132021080588519 -0.8158 -0.915 2072356 Maybridge1_005396 CCOC(=O)NNC(=S)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N07 compound treatment 671710.0 -207000.0 -1.18 774440.0 -156000.0 -0.78 625960.0 -243187.8125 -1.33882184870641 762720.0 -205805.625 -1.22801868890463 -2.2651 -0.9831 1632182 Maybridge1_005397 Cc1ccc(cc1)c2csc(n2)c3ccncc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N08 compound treatment 739520.0 -139000.0 -0.8 783080.0 -147000.0 -0.74 961050.0 91902.1875 0.505949107005159 898810.0 -69715.625 -0.415985182176953 -0.7215 -0.5694 2072357 Maybridge1_005398 COc1ccc(cc1)c2nc(cs2)c3ccc(cc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N09 compound treatment 700810.0 -178000.0 -1.02 664430.0 -266000.0 -1.33 673920.0 -195227.8125 -1.07478766375333 724710.0 -243815.625 -1.45482002324748 -2.4385 -0.9893 2072358 Maybridge1_005399 Fc1ccc(cc1)c2csc(n2)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N10 compound treatment 706740.0 -172000.0 -0.98 764100.0 -166000.0 -0.83 699900.0 -169247.8125 -0.931759971403855 801990.0 -166535.625 -0.993699078285215 -1.8703 -0.9977 2072359 Maybridge1_005400 CNC(=S)N/N=C/c1ccc2OCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N11 compound treatment 733150.0 -146000.0 -0.83 727270.0 -203000.0 -1.02 677850.0 -191297.8125 -1.05315183500301 790350.0 -178175.625 -1.06315363055438 -1.9824 -0.9956 2072360 Maybridge1_005401 [O-][N+](=O)c1cccc(c1)c2csc(Nc3ccccc3Cl)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N12 compound treatment 829640.0 -49200.0 -0.28 889330.0 -41100.0 -0.21 735810.0 -133337.8125 -0.734064650685234 890240.0 -78285.625 -0.467121394629419 -0.8439 -0.9005 2072361 Maybridge1_005402 CCOc1ccccc1/C=N/NC(=S)NC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N13 compound treatment 871710.0 -7110.0 -0.04 823280.0 -107000.0 -0.54 949020.0 79872.1875 0.439720348769431 993200.0 24674.375 0.147229181112232 0.0051 0.0072 2072362 Maybridge1_005403 Clc1ccc(/C=N/NC(=O)N\N=C\c2ccc(Cl)c(Cl)c2)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N14 compound treatment 594730.0 -284000.0 -1.62 632190.0 -298000.0 -1.49 644440.0 -224707.8125 -1.23708390588045 681930.0 -286595.625 -1.71008340349445 -3.0309 -0.9931 2072363 Maybridge1_005404 COc1ccc(NC(=S)NNC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N15 compound treatment 786050.0 -92800.0 -0.53 772420.0 -158000.0 -0.79 779060.0 -90087.8125 -0.495960428432928 877720.0 -90805.625 -0.541826806520304 -1.1791 -0.9808 2072364 Maybridge1_005405 CCOc1ccccc1/C=N/NC(=S)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N16 compound treatment 808570.0 -70300.0 -0.4 815680.0 -115000.0 -0.57 795440.0 -73707.8125 -0.405783615473557 885490.0 -83035.625 -0.495464102814859 -0.9383 -0.9887 1083185 Maybridge1_005406 CNC(=S)NNC(=O)c1ccncc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N17 compound treatment 779440.0 -99400.0 -0.57 936160.0 5700.0 0.03 808930.0 -60217.8125 -0.331517119330583 905850.0 -62675.625 -0.373978305203165 -0.6223 -0.8222 2072365 Maybridge1_005407 Oc1cccc(/C=N/NC(=O)N\N=C\c2cccc(O)c2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N18 compound treatment 758570.0 -120000.0 -0.69 804530.0 -126000.0 -0.63 801760.0 -67387.8125 -0.37099011987507 861960.0 -106565.625 -0.635864928836625 -1.1618 -0.9782 1550576 Maybridge1_005408 CC1CC(CC(C)(C)C1)N2CNC(=S)NC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N19 compound treatment 710400.0 -168000.0 -0.96 808480.0 -122000.0 -0.61 791860.0 -77287.8125 -0.425492589246118 775960.0 -192565.625 -1.14901711914142 -1.5733 -0.9404 2072366 Maybridge1_005409 CCOC(=O)N/N=C/c1ccccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N20 compound treatment 700000.0 -179000.0 -1.02 675290.0 -255000.0 -1.28 673120.0 -196027.8125 -1.07919190370251 714360.0 -254165.625 -1.51657729266207 -2.4468 -0.9877 2072367 Maybridge1_005410 CC(=O)c1sc2ccccc2c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N21 compound treatment 726740.0 -152000.0 -0.87 754200.0 -176000.0 -0.88 812970.0 -56177.8125 -0.309275707587246 830630.0 -137895.625 -0.82280746514185 -1.4412 -0.9494 1934343 Maybridge1_005411 CCOC(=O)N/N=C/c1ccc(F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N22 compound treatment 743780.0 -135000.0 -0.77 1065150.0 135000.0 0.67 829630.0 -39517.8125 -0.217557410645664 852240.0 -116285.625 -0.693863060112935 -0.5046 -0.4017 2072368 Maybridge1_005412 CC(=O)c1sc2ccc(Cl)cc2c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N23 mock treatment 823280.0 -55500.0 -0.32 1044560.0 114000.0 0.57 884870.0 15722.1875 0.0865553578449118 1000800.0 32274.375 0.192577514208935 0.2663 0.388 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 N24 mock treatment 777710.0 -101000.0 -0.58 840850.0 -89600.0 -0.45 788670.0 -80477.8125 -0.443054496043456 942340.0 -26185.625 -0.156246637479652 -0.8125 -0.935 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O01 compound treatment 809780.0 -69000.0 -0.39 795630.0 -135000.0 -0.67 996010.0 126862.1875 0.698414392784134 1089600.0 121074.375 0.722436985128308 0.176 0.1383 1627038 Maybridge1_005413 C(N1CCC(CC1)n2nnc3cccnc23)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O02 compound treatment 759840.0 -119000.0 -0.68 710720.0 -220000.0 -1.1 739430.0 -129717.8125 -0.714135464915215 840050.0 -128475.625 -0.766599399645673 -1.6297 -0.9796 1443998 Maybridge1_005414 CCCCc1ccc(NC(=O)NC2Cc3ccccc3C2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O03 compound treatment 899680.0 20900.0 0.12 775580.0 -155000.0 -0.77 919520.0 50372.1875 0.277314000643581 926990.0 -41535.625 -0.247838336563125 -0.313 -0.3608 2072369 Maybridge1_005415 COC(=O)c1ccc2ncccc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O04 compound treatment 693540.0 -185000.0 -1.06 749160.0 -181000.0 -0.91 638110.0 -231037.8125 -1.27193245447831 731520.0 -237005.625 -1.41418553003846 -2.3257 -0.9863 1532931 Maybridge1_005416 Fc1ccc(NC(=O)NC2Cc3ccccc3C2)c(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O05 compound treatment 688660.0 -190000.0 -1.09 744000.0 -186000.0 -0.93 706410.0 -162737.8125 -0.895920468817438 778440.0 -190085.625 -1.13421924202566 -2.0245 -0.9951 2072370 Maybridge1_005417 Clc1ccc(NC(=O)NCCSCc2ccco2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O06 compound treatment 711100.0 -168000.0 -0.96 675250.0 -255000.0 -1.28 666720.0 -202427.8125 -1.11442582329591 787870.0 -180655.625 -1.07795150767014 -2.2135 -0.9948 1469809 Maybridge1_005418 O=C(NC1Cc2ccccc2C1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O07 compound treatment 863490.0 -15300.0 -0.09 799230.0 -131000.0 -0.66 781170.0 -87977.8125 -0.484344245566977 951600.0 -16925.625 -0.10099327373288 -0.6646 -0.8041 2072371 Maybridge1_005419 O=C(NCCSCc1ccco1)Nc2cccc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O08 compound treatment 742240.0 -137000.0 -0.78 783200.0 -147000.0 -0.74 935140.0 65992.1875 0.363306785651234 826750.0 -141775.625 -0.845958982564903 -0.9997 -0.7071 1635085 Maybridge1_005420 O=C(NC1Cc2ccccc2C1)C3CCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O09 compound treatment 699400.0 -179000.0 -1.02 729470.0 -201000.0 -1.01 753730.0 -115417.8125 -0.6354096758237 797930.0 -170595.625 -1.01792463517635 -1.8418 -0.9843 2072372 Maybridge1_005421 FC(F)(F)c1cc(nc2cc(nn12)c3ccccc3)c4ccco4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O10 compound treatment 747130.0 -132000.0 -0.75 746450.0 -184000.0 -0.92 898850.0 29702.1875 0.163519450956756 872410.0 -96115.625 -0.573510970828658 -1.0413 -0.783 1248490 Maybridge1_005422 O=S(=O)(NC1Cc2ccccc2C1)c3cccc4nonc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O11 compound treatment 651400.0 -227000.0 -1.3 880180.0 -50300.0 -0.25 732910.0 -136237.8125 -0.750030020500996 818560.0 -149965.625 -0.894827778362535 -1.5977 -0.9054 1076165 Maybridge1_005423 Nc1nc(cc(n1)C(F)(F)F)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O12 compound treatment 865850.0 -13000.0 -0.07 979770.0 49300.0 0.25 905810.0 36662.1875 0.201836338514583 1027930.0 59404.375 0.354459129592298 0.3644 0.7554 1250785 Maybridge1_005424 CC(C)(C)OC(=O)NCc1nnc(S)n1Cc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O13 compound treatment 675680.0 -203000.0 -1.16 778660.0 -152000.0 -0.76 940570.0 71422.1875 0.393200564306264 800210.0 -168315.625 -1.00432013524734 -1.2654 -0.7203 2072373 Maybridge1_005425 COc1ccc2cc(ccc2c1)c3cc(nc(N)n3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O14 compound treatment 820450.0 -58400.0 -0.33 891810.0 -38600.0 -0.19 1020090.0 150942.1875 0.83098201525432 905480.0 -63045.625 -0.376186052998662 -0.036 -0.0363 1228553 Maybridge1_005426 O=C(CSc1nnnn1c2ccccc2)NC3Cc4ccccc4C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O15 compound treatment 808530.0 -70300.0 -0.4 805890.0 -125000.0 -0.62 844970.0 -24177.8125 -0.133106109620222 849850.0 -118675.625 -0.708123917494661 -0.9329 -0.9025 2072374 Maybridge1_005427 Cn1c(SCC(=O)Nc2ccccc2)nnc1c3ccc4ncccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O16 compound treatment 978190.0 99400.0 0.57 873360.0 -57100.0 -0.29 896320.0 27172.1875 0.149591042117488 1095100.0 126574.375 0.75525485776408 0.5935 0.5945 1220510 Maybridge1_005428 CC(C)(C)OC(=O)NCc1nnc(S)n1C2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O17 compound treatment 729280.0 -150000.0 -0.85 766890.0 -164000.0 -0.82 943040.0 73892.1875 0.406798655149344 867560.0 -100965.625 -0.602450367607475 -0.934 -0.6728 2072375 Maybridge1_005429 COc1ccc(cc1)c2ccnc(SCC(=O)NCCSCc3ccco3)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O18 compound treatment 686810.0 -192000.0 -1.1 677200.0 -253000.0 -1.27 725710.0 -143437.8125 -0.789668180043576 733200.0 -235325.625 -1.40416116166972 -2.2787 -0.9803 2072376 Maybridge1_005430 Fc1cccc2c(OC3CCN(Cc4ccccc4)CC3)cc(nc12)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O19 compound treatment 753510.0 -125000.0 -0.72 760160.0 -170000.0 -0.85 832360.0 -36787.8125 -0.202527941819102 885830.0 -82695.625 -0.493435361597375 -1.1318 -0.9173 2072377 Maybridge1_005431 FC(F)(F)c1cc(nc2cc(nn12)C3CC3)c4nccs4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O20 compound treatment 801760.0 -77100.0 -0.44 958210.0 27800.0 0.14 895300.0 26152.1875 0.143975636182289 881560.0 -86965.625 -0.518913964534601 -0.3382 -0.4768 2072378 Maybridge1_005432 CCOC(=O)C1CCN(CC1)c2cc(nc3ccc(cc23)C(=O)OCC)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O21 compound treatment 716610.0 -162000.0 -0.93 1028990.0 98500.0 0.49 965040.0 95892.1875 0.527915253751673 812770.0 -155755.625 -0.929376047919102 -0.4176 -0.2788 1467023 Maybridge1_005433 O=C(NCCc1ccccc1)c2ccc3nonc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O22 compound treatment 682130.0 -197000.0 -1.12 891710.0 -38700.0 -0.19 653790.0 -215357.8125 -1.18560935147446 807210.0 -161315.625 -0.9625519337109 -1.7328 -0.9092 1422747 Maybridge1_005434 COc1ccc(cc1)c2ccnc(SCc3ccccc3)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O23 mock treatment 1007040.0 128000.0 0.73 1067310.0 137000.0 0.68 1050500.0 181352.1875 0.998398186322358 1071610.0 103084.375 0.615092707179665 1.5152 0.9821 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 O24 mock treatment 981760.0 103000.0 0.59 1056180.0 126000.0 0.63 1023140.0 153992.1875 0.847773180060552 1086470.0 117944.375 0.703760632155587 1.3842 0.9899 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P01 compound treatment 916320.0 37500.0 0.21 853180.0 -77300.0 -0.39 824480.0 -44667.8125 -0.245909705318482 975470.0 6944.375 0.0414362935063707 -0.1884 -0.3713 2072379 Maybridge1_005435 Cc1ccc(c(c1)[N+](=O)[O-])c2ccc(C)cc2[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P02 compound treatment 322020.0 -557000.0 -3.18 454190.0 -476000.0 -2.38 386520.0 -482627.8125 -2.65701086549467 469510.0 -499015.625 -2.9775693135473 -5.5987 -0.9941 2072380 Maybridge1_005436 COc1cccc(NC(=S)NNc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P03 compound treatment 983440.0 105000.0 0.6 1005630.0 75200.0 0.38 1035070.0 165922.1875 0.913451408302633 1191860.0 223334.375 1.33261074071632 1.6098 0.913 1002354 Maybridge1_005437 CC(=O)Nc1cccc(c1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P04 compound treatment 972010.0 93200.0 0.53 876270.0 -54200.0 -0.27 983420.0 114272.1875 0.629102666583983 1042010.0 73484.375 0.438472883539874 0.6644 0.6836 1783745 Maybridge1_005438 [O-][N+](=O)c1cccc(c1)C(=O)Nc2nccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P05 compound treatment 949480.0 70700.0 0.4 956640.0 26200.0 0.13 989760.0 120612.1875 0.664006268181199 913630.0 -54895.625 -0.327555932638382 0.4355 0.5103 2072381 Maybridge1_005439 CCc1nc2ccccc2[nH]c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P06 compound treatment 948930.0 70100.0 0.4 1040520.0 110000.0 0.55 948280.0 79132.1875 0.435646426816444 938660.0 -29865.625 -0.17820477771595 0.6042 0.73 2072382 Maybridge1_005440 Brc1ccc2NC(=O)/C(=N\NC(=O)N/N=C\3/C(=O)Nc4ccc(Br)cc34)/c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P07 compound treatment 644960.0 -234000.0 -1.34 789550.0 -141000.0 -0.7 766620.0 -102527.8125 -0.564446359642608 664740.0 -303785.625 -1.81265417269607 -2.2089 -0.9105 1288646 Maybridge1_005441 Cc1ccc(c2csc(n2)c3ccncc3)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P08 compound treatment 966510.0 87700.0 0.5 795050.0 -135000.0 -0.68 799620.0 -69527.8125 -0.382771461739114 930590.0 -37935.625 -0.226357547201529 -0.3927 -0.4123 2072383 Maybridge1_005442 CCc1cc2c(cc1c3csc(n3)c4ccc(OC)cc4)C(C)(C)CCC2(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P09 compound treatment 819690.0 -59100.0 -0.34 1058080.0 128000.0 0.64 1001500.0 132352.1875 0.728638489435351 1110020.0 141494.375 0.844280795896029 0.9367 0.705 2072384 Maybridge1_005443 [O-][N+](=O)c1cccc(c1)c2csc(n2)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P10 compound treatment 538740.0 -340000.0 -1.94 732250.0 -198000.0 -0.99 640880.0 -228267.8125 -1.25668277365429 666150.0 -302375.625 -1.80424086352944 -2.9975 -0.9679 2072385 Maybridge1_005444 CNC(=S)N/N=C/c1cc(Br)ccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P11 compound treatment 663220.0 -216000.0 -1.23 624360.0 -306000.0 -1.53 713240.0 -155907.8125 -0.858319270251351 668080.0 -300445.625 -1.79272477367726 -2.7068 -0.9685 2072386 Maybridge1_005445 Clc1ccccc1Nc2nc(cs2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P12 compound treatment 903100.0 24300.0 0.14 942840.0 12400.0 0.06 992030.0 122882.1875 0.676503299036985 999770.0 31244.375 0.186431621697145 0.5318 0.7407 2072387 Maybridge1_005446 CCOc1ccc(/C=N/NC(=S)NC)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P13 compound treatment 788030.0 -90800.0 -0.52 921770.0 -8690.0 -0.04 929130.0 59982.1875 0.330219933033053 903890.0 -64635.625 -0.385673401633367 -0.3088 -0.4247 2072388 Maybridge1_005447 Clc1ccccc1/C=N/NC(=O)N\N=C\c2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P14 compound treatment 624410.0 -254000.0 -1.45 696560.0 -234000.0 -1.17 692360.0 -176787.8125 -0.973269932924835 755540.0 -212985.625 -1.27086092990914 -2.4337 -0.99 2072389 Maybridge1_005448 COc1cc(cc(OC)c1OC)C(=O)NNC(=S)Nc2cccc(c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P15 compound treatment 1059930.0 181000.0 1.03 1082120.0 152000.0 0.76 1093790.0 224642.1875 1.23672262057212 892750.0 -75775.625 -0.45214451093564 1.2888 0.7011 2072390 Maybridge1_005449 CCOc1ccccc1/C=N/Nc2nc(cs2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P16 compound treatment 993120.0 114000.0 0.65 1100600.0 170000.0 0.85 1062310.0 193162.1875 1.06341577857206 1114720.0 146194.375 0.872325159784779 1.7198 0.986 1083198 Maybridge1_005450 C=CCNC(=S)NNC(=O)c1ccncc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P17 compound treatment 855890.0 -22900.0 -0.13 878340.0 -52100.0 -0.26 916430.0 47282.1875 0.26030262383989 760000.0 -208525.625 -1.2442486186445 -0.6878 -0.5274 2072391 Maybridge1_005451 CCOc1ccc(/C=N/NC(=O)N\N=C\c2ccc(OCC)c(OC)c2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P18 compound treatment 883780.0 4960.0 0.03 796160.0 -134000.0 -0.67 981150.0 112002.1875 0.616605635728197 1098820.0 130294.375 0.777451673437729 0.3753 0.3132 1713698 Maybridge1_005452 S=C1NCN(Cc2cccnc2)CN1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P19 compound treatment 948640.0 69800.0 0.4 1028920.0 98500.0 0.49 889640.0 20492.1875 0.112815638541871 1178690.0 210164.375 1.25402685296848 1.1291 0.801 2072392 Maybridge1_005453 CCOC(=O)NNC(=S)Nc1c(C)cccc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P20 compound treatment 84020.0 -795000.0 -4.54 83290.0 -847000.0 -4.24 57030.0 -812117.8125 -4.47095214156201 71270.0 -897255.625 -5.35382196781454 -9.3011 -0.9959 1047435 Maybridge1_005454 O=S1(=O)C=Cc2ccccc21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P21 compound treatment 856220.0 -22600.0 -0.13 874960.0 -55500.0 -0.28 886690.0 17542.1875 0.0965750037292863 930720.0 -37805.625 -0.225581852030138 -0.2678 -0.6827 2072393 Maybridge1_005455 CCOC(=O)N/N=C/c1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P22 compound treatment 767390.0 -111000.0 -0.64 784860.0 -146000.0 -0.73 827890.0 -41257.8125 -0.227136632535121 712290.0 -256235.625 -1.52892874654499 -1.5604 -0.8558 2072394 Maybridge1_005456 CC(=O)c1sc2ccc(C)cc2c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P23 mock treatment 962560.0 83700.0 0.48 954080.0 23600.0 0.12 1042030.0 172882.1875 0.951768295860461 1142370.0 173844.375 1.03730955585371 1.2928 0.8668 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.556 P24 mock treatment 926150.0 47300.0 0.27 939080.0 8620.0 0.04 944330.0 75182.1875 0.413900492067389 1042440.0 73914.375 0.441038644491398 0.5842 0.88 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A01 compound treatment 821680.0 -48800.0 -0.28 793370.0 -55600.0 -0.28 902430.0 -21890.9375 -0.120516176828008 889660.0 -73799.6875 -0.440354317260868 -0.5589 -0.927 2072395 Maybridge1_005809 [O-][N+](=O)c1cccc(c1)c2cc(cc(n2)c3ccccc3)c4cccs4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A02 compound treatment 898180.0 27700.0 0.16 785940.0 -63100.0 -0.32 909800.0 -14520.9375 -0.0799421162962278 910810.0 -52649.6875 -0.31415467976149 -0.2756 -0.5752 1085165 Maybridge1_005810 NNC(=S)NCCc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A03 compound treatment 933760.0 63300.0 0.36 832510.0 -16500.0 -0.08 1011720.0 87399.0625 0.481158053228745 992350.0 28890.3125 0.172385199278664 0.4663 0.7385 2072396 Maybridge1_005811 Cc1cccc(C)c1Nc2nnc(S)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A04 compound treatment 850010.0 -20500.0 -0.12 774410.0 -74600.0 -0.37 910000.0 -14320.9375 -0.0788410563089339 933520.0 -29939.6875 -0.178646700205421 -0.3737 -0.8552 2072397 Maybridge1_005812 S=C(NCc1ccco1)N/N=C/c2cccnc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A05 compound treatment 909760.0 39300.0 0.22 799200.0 -49800.0 -0.25 954850.0 30529.0625 0.168071645841724 965370.0 1910.3125 0.0113986167853678 0.0774 0.2063 1250520 Maybridge1_005813 O=C(NC(=S)NCc1cccnc1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A06 compound treatment 935050.0 64600.0 0.37 844910.0 -4090.0 -0.02 1000340.0 76019.0625 0.418507739951722 903120.0 -60339.6875 -0.360040032592233 0.2034 0.3063 2072398 Maybridge1_005814 CC1=NC2SC=C(N2C(=O)C1)c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A07 compound treatment 894300.0 23800.0 0.14 799750.0 -49200.0 -0.25 920850.0 -3470.9375 -0.0191085519982397 844320.0 -119139.6875 -0.710892925498304 -0.4201 -0.5493 2072399 Maybridge1_005815 CCc1cccc(CC)c1N2C(=O)C(=C(C)C2=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A08 compound treatment 911040.0 40600.0 0.23 800680.0 -48300.0 -0.24 949870.0 25549.0625 0.140655252158106 950820.0 -12639.6875 -0.0754195735510834 0.0276 0.0745 2072400 Maybridge1_005816 Cc1cccc(C)c1n2nnnc2SCC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A09 compound treatment 994360.0 124000.0 0.71 856750.0 7750.0 0.04 1008560.0 84239.0625 0.463761305429502 1046530.0 83070.3125 0.495671079170687 0.8529 0.8691 1398190 Maybridge1_005817 CCOC(=O)c1ccc(NC(=O)CCC(=O)O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A10 compound treatment 920960.0 50500.0 0.29 801040.0 -48000.0 -0.24 957080.0 32759.0625 0.180348464700051 920510.0 -42949.6875 -0.256275886203856 -0.0137 -0.0281 2072401 Maybridge1_005818 Cc1ccc(NC(=S)N2CCCCC2)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A11 compound treatment 909350.0 38900.0 0.22 860400.0 11400.0 0.06 969550.0 45229.0625 0.248999554907826 1006590.0 43130.3125 0.257353654975644 0.3927 0.9236 2072402 Maybridge1_005819 COc1ccc2nsnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A12 compound treatment 439730.0 -431000.0 -2.46 450080.0 -399000.0 -2.0 397290.0 -527030.9375 -2.90146338673622 227040.0 -736419.6875 -4.3941322747 -5.8757 -0.9562 2072403 Maybridge1_005820 Oc1ccccc1C(=O)Nc2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A13 compound treatment 946450.0 76000.0 0.43 826190.0 -22800.0 -0.11 944340.0 20019.0625 0.110210943509429 937070.0 -26389.6875 -0.157464255140513 0.1363 0.2793 1114517 Maybridge1_005821 COc1ccccc1C(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A14 compound treatment 907710.0 37200.0 0.21 809030.0 -40000.0 -0.2 952770.0 28449.0625 0.156620621973867 969220.0 5760.3125 0.0343711276304082 0.1019 0.306 1484645 Maybridge1_005822 COc1cc(cc(OC)c1OC)C(=O)OCC(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A15 compound treatment 989660.0 119000.0 0.68 872110.0 23100.0 0.12 953870.0 29549.0625 0.162676451903984 1077490.0 114030.3125 0.680405867680414 0.8197 0.8339 2072404 Maybridge1_005823 O=c1c2NCCCNc2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A16 compound treatment 1002900.0 132000.0 0.76 947630.0 98600.0 0.49 1011260.0 86939.0625 0.478625615257969 1013680.0 50220.3125 0.299658876246121 1.014 0.952 1666948 Maybridge1_005824 OC(=O)CCC(=O)Nc1cccnc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A17 compound treatment 985710.0 115000.0 0.66 853070.0 4070.0 0.02 981370.0 57049.0625 0.314072200156895 1045970.0 82510.3125 0.492329623047772 0.7425 0.8436 1938917 Maybridge1_005825 CC(=O)Nc1ccc(I)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A18 compound treatment 596320.0 -274000.0 -1.57 531110.0 -318000.0 -1.59 554920.0 -369400.9375 -2.03366295775053 533320.0 -430139.6875 -2.56659445090286 -3.8782 -0.9786 2072405 Maybridge1_005826 COc1ccc(cc1)/C(=C/c2ccccc2OC)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A19 compound treatment 939610.0 69100.0 0.39 886400.0 37400.0 0.19 1041180.0 116859.0625 0.643344189357137 1048350.0 84890.3125 0.50653081157016 0.8659 0.933 2072406 Maybridge1_005827 FC(F)(F)c1cccc(NC(=S)Nc2ccc(NC(=S)Nc3cccc(c3)C(F)(F)F)cc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A20 compound treatment 709280.0 -161000.0 -0.92 637210.0 -212000.0 -1.06 704110.0 -220210.9375 -1.21232726022864 732220.0 -231239.6875 -1.37978083867467 -2.2861 -0.989 2072407 Maybridge1_005828 Clc1ccc(Cl)c(NC(=N)SCc2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A21 compound treatment 880270.0 9790.0 0.06 769050.0 -79900.0 -0.4 957480.0 33159.0625 0.182550584674639 943100.0 -20359.6875 -0.12148393295984 -0.1414 -0.3078 2072408 Maybridge1_005829 COCCCNC(=S)Nc1cccc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A22 compound treatment 946900.0 76400.0 0.44 869220.0 20200.0 0.1 999760.0 75439.0625 0.41531466598857 981060.0 17600.3125 0.105019057086325 0.529 0.8533 1421262 Maybridge1_005830 COc1ccc(CCNC(=S)Nc2ccc(Cl)cc2Cl)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A23 mock treatment 918320.0 47800.0 0.27 911970.0 63000.0 0.31 1023440.0 99119.0625 0.545680168484168 1025950.0 62490.3125 0.372872566653562 0.7534 0.9641 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 A24 mock treatment 910080.0 39600.0 0.23 889920.0 40900.0 0.2 926670.0 2349.0625 0.0129322936320129 973460.0 10000.3125 0.0596707239896215 0.2517 0.8092 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B01 compound treatment 755250.0 -115000.0 -0.66 617050.0 -232000.0 -1.16 744270.0 -180050.9375 -0.991234414780027 785700.0 -177759.6875 -1.0606717789363 -1.9351 -0.9816 2072409 Maybridge1_005831 CC(C)(CO)/N=C/c1cc(Cl)cc(Cl)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B02 compound treatment 853000.0 -17500.0 -0.1 853370.0 4370.0 0.02 973450.0 49129.0625 0.270470224660057 1024350.0 60890.3125 0.363325549159519 0.2779 0.5985 1598073 Maybridge1_005832 Cc1onc(c1C(=O)NN2CCCCC2)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B03 compound treatment 817340.0 -53100.0 -0.3 739290.0 -110000.0 -0.55 870000.0 -54320.9375 -0.299053053767715 931650.0 -31809.6875 -0.189804776901583 -0.6706 -0.9311 2072410 Maybridge1_005833 CC(=O)Nc1ccc(OCCCCCCOc2ccc(Cl)cc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B04 compound treatment 813720.0 -56800.0 -0.32 734810.0 -114000.0 -0.57 786180.0 -138140.9375 -0.760507294442589 862730.0 -100729.6875 -0.601042555457475 -1.1285 -0.9638 2072411 Maybridge1_005834 Cc1ccc(Sc2nc(C)c([N+](=O)[O-])c(C)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B05 compound treatment 711900.0 -159000.0 -0.91 629860.0 -219000.0 -1.1 669480.0 -254840.9375 -1.40297579702858 690620.0 -272839.6875 -1.62800329351979 -2.5164 -0.9765 2072412 Maybridge1_005835 CCOC(=O)CSC(=S)Nc1ccc(C)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B06 compound treatment 702080.0 -168000.0 -0.96 691090.0 -158000.0 -0.79 740020.0 -184300.9375 -1.01463193951002 834130.0 -129329.6875 -0.771695493163489 -1.769 -0.9929 1704501 Maybridge1_005836 Cc1onc(c1C(=S)N)c2c(F)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B07 compound treatment 844240.0 -26200.0 -0.15 696530.0 -152000.0 -0.76 836860.0 -87460.9375 -0.481498693662314 877130.0 -86329.6875 -0.51511939801109 -0.9545 -0.9096 2072413 Maybridge1_005837 CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B08 compound treatment 321920.0 -549000.0 -3.13 360800.0 -488000.0 -2.44 420910.0 -503410.9375 -2.77142820223681 313080.0 -650379.6875 -3.88074140895785 -6.1138 -0.985 2072414 Maybridge1_005838 CN(C)NC(=O)Nc1c(C)onc1c2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B09 compound treatment 808900.0 -61600.0 -0.35 668400.0 -181000.0 -0.9 727580.0 -196740.9375 -1.0831178707197 771150.0 -192309.6875 -1.14748996927275 -1.7428 -0.9411 2072415 Maybridge1_005839 Clc1ccccc1NC(=S)SCCSC(=S)Nc2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B10 compound treatment 832200.0 -38300.0 -0.22 681300.0 -168000.0 -0.84 789050.0 -135270.9375 -0.744707083624922 835220.0 -128239.6875 -0.765191587495672 -1.2837 -0.9334 1642340 Maybridge1_005840 CCc1onc(c1C(=O)O)c2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B11 compound treatment 878370.0 7890.0 0.05 719010.0 -130000.0 -0.65 809500.0 -114820.9375 -0.63212369992412 868430.0 -95029.6875 -0.567031305634948 -0.9021 -0.8428 2072416 Maybridge1_005841 COc1cc(/C=N/OC(=O)c2ccc(Cl)cc2Cl)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B12 compound treatment 933000.0 62500.0 0.36 795060.0 -53900.0 -0.27 844030.0 -80290.9375 -0.442025693117828 805170.0 -158289.6875 -0.944496509805663 -0.6496 -0.5724 2072417 Maybridge1_005842 OC(=O)c1coc2ccccc2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B13 compound treatment 907710.0 37200.0 0.21 843840.0 -5160.0 -0.03 896810.0 -27510.9375 -0.151455962470967 1053710.0 90250.3125 0.538513320175203 0.287 0.4791 1450030 Maybridge1_005843 OC(=O)c1cnc2sc3ccccc3n2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B14 compound treatment 871360.0 879.0 0.01 705120.0 -144000.0 -0.72 828290.0 -96030.9375 -0.528679114117858 911290.0 -52169.6875 -0.311290574513277 -0.7773 -0.8219 2072418 Maybridge1_005844 Cc1onc(c1NC(=O)O/N=C/c2ccc(F)cc2)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B15 compound treatment 859840.0 -10600.0 -0.06 728160.0 -121000.0 -0.6 764440.0 -159880.9375 -0.880192515061437 829820.0 -133639.6875 -0.797412771538067 -1.1714 -0.8781 2072419 Maybridge1_005845 CC(C)(C)CC(C)(C)NC(=O)c1cccs1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B16 compound treatment 893180.0 22700.0 0.13 772000.0 -77000.0 -0.39 820180.0 -104140.9375 -0.573327096602626 909000.0 -54459.6875 -0.324954743301626 -0.5769 -0.7451 2072420 Maybridge1_005846 Clc1cncc(Cl)c1N/N=C/c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B17 compound treatment 851850.0 -18600.0 -0.11 793690.0 -55300.0 -0.28 866280.0 -58040.9375 -0.319532769531381 936920.0 -26539.6875 -0.15835928803058 -0.4305 -0.9283 2072421 Maybridge1_005847 ClC(Cl)(Cl)C(=O)NCCOC(=O)C(Cl)(Cl)Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B18 compound treatment 801760.0 -68700.0 -0.39 784390.0 -64600.0 -0.32 809190.0 -115130.9375 -0.633830342904426 798240.0 -165219.6875 -0.985847029326736 -1.1677 -0.914 2072422 Maybridge1_005848 FC(F)(F)c1ccc(NC(=O)O/N=C/c2ccccn2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B19 compound treatment 944800.0 74300.0 0.42 838050.0 -10900.0 -0.05 807730.0 -116590.9375 -0.641868080811671 1025200.0 61740.3125 0.368397402203229 0.0482 0.0563 2072423 Maybridge1_005849 FC(F)(F)c1cc(nc(S)c1C#N)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B20 compound treatment 862950.0 -7530.0 -0.04 860110.0 11100.0 0.06 858080.0 -66240.9375 -0.364676229010431 1014500.0 51040.3125 0.304551722711818 -0.0238 -0.0495 1421916 Maybridge1_005850 Cc1nccc(O)c1OCc2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B21 compound treatment 859110.0 -11400.0 -0.06 801450.0 -47500.0 -0.24 880320.0 -44000.9375 -0.242238358423349 1023760.0 60300.3125 0.359805086458591 -0.0926 -0.1856 1003776 Maybridge1_005851 CCOC(=O)C1=C(C)NC(=O)NC1c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B22 compound treatment 952610.0 82100.0 0.47 846640.0 -2360.0 -0.01 909460.0 -14860.9375 -0.0818139182746274 962590.0 -869.6875 -0.00518932611053144 0.1852 0.3887 2072424 Maybridge1_005852 N/C(=N\OC(=O)C(Cl)Cl)/c1ccc(OCc2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B23 mock treatment 983050.0 113000.0 0.64 963210.0 114000.0 0.57 1018080.0 93759.0625 0.516171760824691 1076920.0 113460.3125 0.677004742698161 1.2037 0.9947 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 B24 mock treatment 991680.0 121000.0 0.69 961460.0 112000.0 0.56 1014940.0 90619.0625 0.498885119024177 1035010.0 71550.3125 0.426932553213579 1.0903 0.9844 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C01 compound treatment 719140.0 -151000.0 -0.86 726720.0 -122000.0 -0.61 809120.0 -115200.9375 -0.634215713899979 845280.0 -118179.6875 -0.705164715001879 -1.4077 -0.9903 2072425 Maybridge1_005853 O=C/1OC(=N\C1=C\c2cccs2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C02 compound treatment 686090.0 -184000.0 -1.05 603640.0 -245000.0 -1.23 661050.0 -263270.9375 -1.44938547549302 677990.0 -285469.6875 -1.70336506286339 -2.7166 -0.9843 2072426 Maybridge1_005854 Clc1ccc(/C=N/NC(=S)NCCc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C03 compound treatment 763120.0 -107000.0 -0.61 633460.0 -216000.0 -1.08 744260.0 -180060.9375 -0.991289467779392 732540.0 -230919.6875 -1.37787143517587 -2.0302 -0.9657 1083084 Maybridge1_005855 O=C(NC(=S)N1CCOCC1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C04 compound treatment 703530.0 -167000.0 -0.95 705200.0 -144000.0 -0.72 747430.0 -176890.9375 -0.973837666980783 731450.0 -232009.6875 -1.38437534084368 -2.0156 -0.9729 2072427 Maybridge1_005856 Clc1ccc(/C=N/NC(=S)NCC2CCCO2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C05 compound treatment 769650.0 -101000.0 -0.58 625810.0 -223000.0 -1.12 750500.0 -173820.9375 -0.956936396175822 732360.0 -231099.6875 -1.37894547464395 -2.0141 -0.9607 2072428 Maybridge1_005857 CC1=C(C)C(=O)N(C1=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C06 compound treatment 755060.0 -115000.0 -0.66 667200.0 -182000.0 -0.91 762270.0 -162050.9375 -0.892139015923575 906880.0 -56579.6875 -0.337604541481233 -1.3992 -0.9495 2072429 Maybridge1_005858 Cc1ccc(cc1)S(=O)(=O)NNC(=S)NCCc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C07 compound treatment 643910.0 -227000.0 -1.29 573520.0 -275000.0 -1.38 617700.0 -306620.9375 -1.68804022773897 652520.0 -310939.6875 -1.85534164759668 -3.1077 -0.9894 2072430 Maybridge1_005859 O=C/1Nc2ccccc2S\C1=C\c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C08 compound treatment 672700.0 -198000.0 -1.13 595040.0 -254000.0 -1.27 639130.0 -285190.9375 -1.57006165010043 666480.0 -296979.6875 -1.77204391996116 -2.871 -0.985 1004237 Maybridge1_005860 Clc1ccc(cc1)c2cc3ccccc3[nH]2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C09 compound treatment 769170.0 -101000.0 -0.58 671870.0 -177000.0 -0.89 739870.0 -184450.9375 -1.01545773450049 817210.0 -146249.6875 -0.872655203162991 -1.6764 -0.9823 1190809 Maybridge1_005861 CCOC(=O)c1ccc(cc1)N2C(=O)CCC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C10 compound treatment 443850.0 -427000.0 -2.44 369550.0 -479000.0 -2.4 372600.0 -551720.9375 -3.03738924216765 445200.0 -518259.6875 -3.09239643938727 -5.4824 -0.9931 2072431 Maybridge1_005862 CCCOc1ccccc1/C=N/NC(=S)Nc2cccc(F)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C11 compound treatment 650100.0 -220000.0 -1.26 592380.0 -257000.0 -1.28 659720.0 -264600.9375 -1.45670752440852 653560.0 -309899.6875 -1.84913608622555 -2.9241 -0.9872 1077735 Maybridge1_005863 [O-][N+](=O)c1ccc2nsnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C12 compound treatment 710080.0 -160000.0 -0.92 622310.0 -227000.0 -1.13 713920.0 -210400.9375 -1.15832026785188 751800.0 -211659.6875 -1.26294921209133 -2.2357 -0.9937 1587025 Maybridge1_005864 Nc1ccc(NC(=O)c2ccccc2O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C13 compound treatment 727420.0 -143000.0 -0.82 733120.0 -116000.0 -0.58 761770.0 -162550.9375 -0.89489166589181 797500.0 -165959.6875 -0.99026252491773 -1.641 -0.9833 2072432 Maybridge1_005865 Cc1c(C)c2nsnc2cc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C14 compound treatment 758310.0 -112000.0 -0.64 694400.0 -155000.0 -0.77 764870.0 -159450.9375 -0.877825236088755 789820.0 -173639.6875 -1.03608820888914 -1.664 -0.9852 2072433 Maybridge1_005866 Cc1cc(ccc1[N+](=O)[O-])C(=O)OCC(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C15 compound treatment 781480.0 -89000.0 -0.51 719300.0 -130000.0 -0.65 758280.0 -166040.9375 -0.914105162670089 760370.0 -203089.6875 -1.21181299963886 -1.6415 -0.9504 1006765 Maybridge1_005867 NC(=O)c1ccccc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C16 compound treatment 752760.0 -118000.0 -0.67 759960.0 -89000.0 -0.45 774660.0 -149660.9375 -0.823928349710718 788170.0 -175289.6875 -1.04593357067987 -1.4938 -0.9596 2072434 Maybridge1_005868 CC1(CO)CS/C(=N/c2ccc(F)cc2)/N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C17 compound treatment 809240.0 -61200.0 -0.35 771480.0 -77500.0 -0.39 794900.0 -129420.9375 -0.712501078996575 837340.0 -126119.6875 -0.752541789316066 -1.1013 -0.949 2072435 Maybridge1_005869 FC(F)(F)c1ccc2nccnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C18 compound treatment 718420.0 -152000.0 -0.87 610120.0 -239000.0 -1.19 645230.0 -279090.9375 -1.53647932048797 699580.0 -263879.6875 -1.57453999555315 -2.5872 -0.9763 1481839 Maybridge1_005870 Nc1cc(NC(=O)c2ccccc2O)ccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C19 compound treatment 800970.0 -69500.0 -0.4 713870.0 -135000.0 -0.68 795790.0 -128530.9375 -0.707601362053117 780500.0 -182959.6875 -1.09169958579193 -1.4361 -0.9455 2072436 Maybridge1_005871 OC(=O)CCNC(=S)Nc1cc(Cl)ccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C20 compound treatment 741620.0 -129000.0 -0.74 740250.0 -109000.0 -0.54 802290.0 -122030.9375 -0.671816912466065 806720.0 -156739.6875 -0.935247836608309 -1.4435 -0.9814 2072437 Maybridge1_005872 Cc1cccc(C)c1NC(=N)NC(=N)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C21 compound treatment 768400.0 -102000.0 -0.58 706510.0 -142000.0 -0.71 761600.0 -162720.9375 -0.89582756688101 796580.0 -166879.6875 -0.995752059976805 -1.5937 -0.9805 1271117 Maybridge1_005873 CCOC(=O)c1cc2cc(Cl)cc(Cl)c2oc1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C22 compound treatment 805640.0 -64800.0 -0.37 742080.0 -107000.0 -0.53 788830.0 -135490.9375 -0.745918249610945 850320.0 -113139.6875 -0.675091609895644 -1.1631 -0.9708 1735016 Maybridge1_005874 Clc1ccc(cc1)C(=O)COC(=O)c2ccccc2Nc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C23 mock treatment 861840.0 -8640.0 -0.05 837410.0 -11600.0 -0.06 803240.0 -121080.9375 -0.666586877526419 940580.0 -22879.6875 -0.136520485512957 -0.4552 -0.6649 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 C24 mock treatment 795940.0 -74500.0 -0.43 854080.0 5080.0 0.03 764320.0 -160000.9375 -0.880853151053813 866280.0 -97179.6875 -0.579860110392567 -0.9305 -0.818 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D01 compound treatment 622850.0 -248000.0 -1.41 655220.0 -194000.0 -0.97 637950.0 -286370.9375 -1.57655790402547 639370.0 -324089.6875 -1.93380619762584 -2.9471 -0.9734 2072438 Maybridge1_005875 CC[n+]1c(C)csc1Nc2ccc(C)cc2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D02 compound treatment 798960.0 -71500.0 -0.41 732370.0 -117000.0 -0.58 819310.0 -105010.9375 -0.578116707547354 897470.0 -65989.6875 -0.393752938118072 -0.9819 -0.9836 1023658 Maybridge1_005876 OC(=O)CSc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D03 compound treatment 711600.0 -159000.0 -0.91 655370.0 -194000.0 -0.97 743260.0 -181060.9375 -0.996794767715861 777890.0 -185569.6875 -1.10727315807909 -1.9901 -0.9974 2072439 Maybridge1_005877 CCOC(=O)C(C)Oc1ccc(NC(=O)C(Cl)Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D04 compound treatment 713480.0 -157000.0 -0.9 638560.0 -210000.0 -1.05 743430.0 -180890.9375 -0.995858866726661 785440.0 -178019.6875 -1.06222316927908 -2.0037 -0.9979 1491174 Maybridge1_005878 CN(C(=O)N(C)C(=O)c1c(C)onc1c2c(F)cccc2Cl)C(=O)c3c(C)onc3c4c(F)cccc4Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D05 compound treatment 538190.0 -332000.0 -1.9 457310.0 -392000.0 -1.96 478510.0 -445810.9375 -2.45432292589617 581020.0 -382439.6875 -2.28197399186171 -4.2968 -0.9944 2072440 Maybridge1_005879 CCOC(=O)CSC(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D06 compound treatment 552160.0 -318000.0 -1.82 471110.0 -378000.0 -1.89 611370.0 -312950.9375 -1.72288877633683 602630.0 -360829.6875 -2.1530295868328 -3.7922 -0.9965 1326646 Maybridge1_005880 Cc1onc(c1C(=S)N)c2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D07 compound treatment 651520.0 -219000.0 -1.25 573500.0 -275000.0 -1.38 686090.0 -238230.9375 -1.31153276508382 762100.0 -201359.6875 -1.20149028697343 -2.5709 -0.9987 1029766 Maybridge1_005881 Cc1c(Cc2ccccc2)c(=O)oc3cc(O)ccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D08 compound treatment 734570.0 -136000.0 -0.78 652130.0 -197000.0 -0.98 737370.0 -186950.9375 -1.02922098434167 758730.0 -204729.6875 -1.22159869257025 -2.0059 -0.9878 2072441 Maybridge1_005882 Clc1cccc(Cl)c1/C=C/2\C(=O)ON=C2c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D09 compound treatment 865890.0 -4590.0 -0.03 639740.0 -209000.0 -1.05 746150.0 -178170.9375 -0.980884450899464 726320.0 -237139.6875 -1.41498546568396 -1.7344 -0.8607 1275847 Maybridge1_005883 Clc1ccc(NC(=S)CCC(=S)Nc2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D10 compound treatment 679320.0 -191000.0 -1.09 570840.0 -278000.0 -1.39 653280.0 -271040.9375 -1.49216165599939 665600.0 -297859.6875 -1.77729477958288 -2.8763 -0.9858 1317532 Maybridge1_005884 CC(C)(C)c1cc(nn1c2ccccc2)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D11 compound treatment 759360.0 -111000.0 -0.63 665370.0 -184000.0 -0.92 787960.0 -136360.9375 -0.750707860555674 796350.0 -167109.6875 -0.997124443741574 -1.6505 -0.9856 1536772 Maybridge1_005885 COc1cccc(Cl)c1c2nc(N)nc(N)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D12 compound treatment 725540.0 -145000.0 -0.83 641460.0 -208000.0 -1.04 720880.0 -203440.9375 -1.12000338029405 733990.0 -229469.6875 -1.36921945057189 -2.1776 -0.9845 2072442 Maybridge1_005886 Clc1ccc(Sc2c(Cl)cncc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D13 compound treatment 836520.0 -34000.0 -0.19 724260.0 -125000.0 -0.62 1065760.0 141439.0625 0.778664461795558 756080.0 -207379.6875 -1.23741094029476 -0.6383 -0.3986 2072443 Maybridge1_005887 NNC(=O)COc1ccc(OC(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D14 compound treatment 774290.0 -96200.0 -0.55 686090.0 -163000.0 -0.81 732520.0 -191800.9375 -1.05592168903354 881020.0 -82439.6875 -0.491908211728699 -1.4561 -0.9554 2072444 Maybridge1_005888 CN(C)c1ccc(/C=N/OC(=O)Nc2c(C)onc2c3c(Cl)cccc3Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D15 compound treatment 685880.0 -185000.0 -1.05 616030.0 -233000.0 -1.17 682910.0 -241410.9375 -1.3290396188818 691900.0 -271559.6875 -1.62036567952455 -2.5846 -0.9867 2072445 Maybridge1_005889 Cc1cc(C)c(C#N)c(OC(=O)c2ccccc2Cl)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D16 compound treatment 664280.0 -206000.0 -1.18 554410.0 -295000.0 -1.47 676840.0 -247480.9375 -1.36245678949617 684990.0 -278469.6875 -1.66159686132695 -2.8377 -0.9924 2072446 Maybridge1_005890 Clc1cncc(Cl)c1N/N=C/C2CC3CC2C=C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D17 compound treatment 725120.0 -145000.0 -0.83 615170.0 -234000.0 -1.17 677960.0 -246360.9375 -1.35629085356732 686880.0 -276579.6875 -1.65031944691211 -2.5032 -0.9729 1274198 Maybridge1_005891 Cc1cc(C)c2c(N)c(sc2n1)C(=O)c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D18 compound treatment 536410.0 -334000.0 -1.91 460510.0 -388000.0 -1.94 521050.0 -403270.9375 -2.22012746659875 514080.0 -449379.6875 -2.68139733626873 -4.3765 -0.9902 2072447 Maybridge1_005892 FC(F)(F)c1ccc(NC(=O)O/N=C/c2c(Cl)cccc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D19 compound treatment 780160.0 -90300.0 -0.52 873170.0 24200.0 0.12 885720.0 -38600.9375 -0.212509738766414 966720.0 3260.3125 0.0194539127959664 -0.294 -0.5147 1942919 Maybridge1_005893 Cc1cc(C)c(C#N)c(SCC#C)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D20 compound treatment 772820.0 -97700.0 -0.56 708800.0 -140000.0 -0.7 754720.0 -169600.9375 -0.93370403044392 782470.0 -180989.6875 -1.07994482050239 -1.6364 -0.9708 1656205 Maybridge1_005894 CCOC(=O)Cn1cc(Cl)c(=O)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D21 compound treatment 760480.0 -110000.0 -0.63 704210.0 -145000.0 -0.72 747520.0 -176800.9375 -0.973342189986501 806250.0 -157209.6875 -0.938052272997184 -1.632 -0.9847 1270254 Maybridge1_005895 CCOC(=O)C1=C(C)NC(=O)NC1c2cc(OC)c(OC)c(OC)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D22 compound treatment 736350.0 -134000.0 -0.77 717690.0 -131000.0 -0.66 811850.0 -112470.9375 -0.619186245073417 813890.0 -149569.6875 -0.89246526446313 -1.4673 -0.9896 1520983 Maybridge1_005896 Clc1ccc(COc2ccc(cc2)c3noc(n3)C4CC4)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D23 mock treatment 789480.0 -81000.0 -0.46 791200.0 -57800.0 -0.29 781550.0 -142770.9375 -0.785996833148443 862520.0 -100939.6875 -0.602295601503568 -1.07 -0.9464 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 D24 mock treatment 896520.0 26000.0 0.15 797710.0 -51300.0 -0.26 913250.0 -11070.9375 -0.060948831515408 1016870.0 53410.3125 0.318693242374869 0.075 0.1706 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E01 compound treatment 876270.0 5790.0 0.03 825120.0 -23900.0 -0.12 921640.0 -2680.9375 -0.0147593650484287 965720.0 2260.3125 0.0134870268621897 -0.0438 -0.349 2072448 Maybridge1_005897 C1Oc2ccc(/N=C/c3cccs3)cc2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E02 compound treatment 866960.0 -3520.0 -0.02 650720.0 -198000.0 -0.99 681980.0 -242340.9375 -1.33415954782271 794200.0 -169259.6875 -1.00995324849919 -1.678 -0.8626 2072449 Maybridge1_005898 S=C(NCCc1ccccc1)N/N=C/c2ccc3OCOc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E03 compound treatment 690470.0 -180000.0 -1.03 604880.0 -244000.0 -1.22 730170.0 -194150.9375 -1.06885914388425 700590.0 -262869.6875 -1.56851344076003 -2.4433 -0.9852 1085188 Maybridge1_005899 CCOC(=O)NC(=S)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E04 compound treatment 788090.0 -82400.0 -0.47 644030.0 -205000.0 -1.03 712640.0 -211680.9375 -1.16536705177056 724000.0 -239459.6875 -1.42882864105032 -2.045 -0.9461 2072450 Maybridge1_005900 S=C(NCC1CCCO1)N/N=C/c2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E05 compound treatment 740260.0 -130000.0 -0.74 642290.0 -207000.0 -1.03 772070.0 -152250.9375 -0.838187076546174 731360.0 -232099.6875 -1.38491236057772 -2.0004 -0.9712 2072451 Maybridge1_005901 Cc1ccccc1SC(CC(=O)c2ccc3ccccc3c2)c4ccc(Cl)c(Cl)c4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E06 compound treatment 838040.0 -32400.0 -0.19 707360.0 -142000.0 -0.71 780120.0 -144200.9375 -0.793869412057595 781970.0 -181489.6875 -1.08292826346928 -1.3853 -0.9057 2072452 Maybridge1_005902 Cc1ccc(cc1)S(=O)(=O)NNC(=S)Nc2cccc(F)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E07 compound treatment 700890.0 -170000.0 -0.97 629600.0 -219000.0 -1.1 605190.0 -319130.9375 -1.75691152994421 743920.0 -219539.6875 -1.30996827324949 -2.5665 -0.9738 2072453 Maybridge1_005903 Clc1ccc(/C=C\2/Sc3ccccc3NC2=O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E08 compound treatment 709290.0 -161000.0 -0.92 640890.0 -208000.0 -1.04 745830.0 -178490.9375 -0.982646146879134 748910.0 -214549.6875 -1.28019351243994 -2.1122 -0.9918 1052672 Maybridge1_005904 c1c([nH]c2ccccc12)c3ccc4ccccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E09 compound treatment 804750.0 -65700.0 -0.38 759760.0 -89200.0 -0.45 796250.0 -128070.9375 -0.705068924082341 779160.0 -184299.6875 -1.0996952129432 -1.3133 -0.918 1022340 Maybridge1_005905 CC(=O)Nc1cccc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E10 compound treatment 746810.0 -124000.0 -0.71 611290.0 -238000.0 -1.19 771920.0 -152400.9375 -0.839012871536645 719530.0 -243929.6875 -1.4555006211743 -2.0949 -0.9627 2072454 Maybridge1_005906 CCCOc1ccccc1/C=N/NC(=S)Nc2ccc(F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E11 compound treatment 794670.0 -75800.0 -0.43 686830.0 -162000.0 -0.81 813660.0 -110660.9375 -0.609221652188407 843200.0 -120259.6875 -0.717575837744134 -1.2855 -0.9769 2072455 Maybridge1_005907 Fc1cc2nsnc2cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E12 compound treatment 775960.0 -94500.0 -0.54 704390.0 -145000.0 -0.72 740080.0 -184240.9375 -1.01430162151383 924500.0 -38959.6875 -0.232468011328087 -1.255 -0.9111 1296646 Maybridge1_005908 Fc1ccccc1Nc2ccccc2C(=O)OCC(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E13 compound treatment 1017860.0 147000.0 0.84 967040.0 118000.0 0.59 846150.0 -78170.9375 -0.430354457252512 832270.0 -131189.6875 -0.782793901000314 0.1096 0.0804 1722583 Maybridge1_005909 NNC(=O)c1ccc2nsnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E14 compound treatment 758400.0 -112000.0 -0.64 707170.0 -142000.0 -0.71 765850.0 -158470.9375 -0.872430042151015 1096770.0 133310.3125 0.795447428483629 -0.7133 -0.4696 2072456 Maybridge1_005910 Cc1onc(c1C(=O)OCC(=O)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E15 compound treatment 728440.0 -142000.0 -0.81 720590.0 -128000.0 -0.64 772640.0 -151680.9375 -0.835049055582387 826580.0 -136879.6875 -0.816745481963503 -1.5527 -0.995 1592470 Maybridge1_005911 CC(C)(Oc1ccc(Cl)cc1)C(=O)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E16 compound treatment 749360.0 -121000.0 -0.69 677190.0 -172000.0 -0.86 770080.0 -154240.9375 -0.849142623419749 848710.0 -114749.6875 -0.684698296249024 -1.5425 -0.9942 2072457 Maybridge1_005912 COc1ccc(/N=C\2/NC(C)(CO)CS2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E17 compound treatment 702950.0 -168000.0 -0.96 638240.0 -211000.0 -1.05 775520.0 -148800.9375 -0.819193791765354 826800.0 -136659.6875 -0.815432767058072 -1.8229 -0.994 2072458 Maybridge1_005913 Cc1cc2nsnc2cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E18 compound treatment 707240.0 -163000.0 -0.93 608770.0 -240000.0 -1.2 732600.0 -191720.9375 -1.05548126503863 710020.0 -253439.6875 -1.51224570640452 -2.3509 -0.9835 2072459 Maybridge1_005914 COc1c(Br)cc(cc1Br)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E19 compound treatment 748960.0 -122000.0 -0.69 704490.0 -145000.0 -0.72 1140660.0 216339.0625 1.19101142703712 1118080.0 154620.3125 0.922601767732411 0.3483 0.1925 2072460 Maybridge1_005915 CSC(=N)Nc1cc(Cl)ccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E20 compound treatment 764200.0 -106000.0 -0.61 670620.0 -178000.0 -0.89 778360.0 -145960.9375 -0.803558739945781 779480.0 -183979.6875 -1.09778580944439 -1.7003 -0.9792 2072461 Maybridge1_005916 Cc1ccc(NC(=N)NC(=N)N)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E21 compound treatment 725340.0 -145000.0 -0.83 674330.0 -175000.0 -0.87 727380.0 -196940.9375 -1.084218930707 743960.0 -219499.6875 -1.30972959781214 -2.0483 -0.9831 2072462 Maybridge1_005917 COc1ccc(NC(=S)N/N=C/c2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E22 compound treatment 722080.0 -148000.0 -0.85 759150.0 -89800.0 -0.45 743940.0 -180380.9375 -0.993051163759062 998830.0 35370.3125 0.211050620129537 -1.0396 -0.7442 1568412 Maybridge1_005918 COc1ccc(CCNC(=S)Nc2ccc(Cl)cc2C)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E23 mock treatment 839880.0 -30600.0 -0.17 807790.0 -41200.0 -0.21 860760.0 -63560.9375 -0.349922025180693 959150.0 -4309.6875 -0.0257154137227234 -0.3783 -0.8541 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 E24 mock treatment 799050.0 -71400.0 -0.41 941170.0 92200.0 0.46 1097780.0 173459.0625 0.954944165761312 1132580.0 169120.3125 1.00912161377217 1.0085 0.6637 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F01 compound treatment 747390.0 -123000.0 -0.7 706130.0 -143000.0 -0.71 767420.0 -156900.9375 -0.863786721250758 800160.0 -163299.6875 -0.974390608333884 -1.6279 -0.9906 1047734 Maybridge1_005919 [O-][N+](=O)c1ccc(OCCCOc2ccc(cc2)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F02 compound treatment 714300.0 -156000.0 -0.89 734840.0 -114000.0 -0.57 809020.0 -115300.9375 -0.634766243893626 834820.0 -128639.6875 -0.767578341869183 -1.4327 -0.9854 2072463 Maybridge1_005920 Cc1onc(c1C(=O)NNc2ccccc2)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F03 compound treatment 689920.0 -181000.0 -1.03 609380.0 -240000.0 -1.2 712030.0 -212290.9375 -1.1687252847318 731540.0 -231919.6875 -1.38383832110964 -2.3912 -0.9945 2072464 Maybridge1_005921 CCOC(=O)C(C)Oc1ccc(NC(=O)C(Cl)(Cl)Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F04 compound treatment 719140.0 -151000.0 -0.86 627630.0 -221000.0 -1.11 723840.0 -200480.9375 -1.1037076924821 796750.0 -166709.6875 -0.994737689368063 -2.0351 -0.9953 2072465 Maybridge1_005922 NC(=S)N/N=C/c1ccc(s1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F05 compound treatment 680730.0 -190000.0 -1.08 603010.0 -246000.0 -1.23 704050.0 -220270.9375 -1.21265757822483 729440.0 -234019.6875 -1.39636878157057 -2.4616 -0.996 2072466 Maybridge1_005923 CCOC(=O)c1ccc(OCc2ccc(cc2)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F06 compound treatment 709780.0 -161000.0 -0.92 652000.0 -197000.0 -0.99 767620.0 -156700.9375 -0.862685661263464 740440.0 -223019.6875 -1.33073303629903 -2.0484 -0.9845 1017491 Maybridge1_005924 OC(=O)c1cc(O)nc2ccc(Br)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F07 compound treatment 710330.0 -160000.0 -0.91 653660.0 -195000.0 -0.98 916960.0 -7360.9375 -0.0405241687511061 787700.0 -175759.6875 -1.04873800706874 -1.4906 -0.8763 2072467 Maybridge1_005925 Cc1nc(SCC(=O)c2ccc(Cl)cc2)nc(O)c1CC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F08 compound treatment 659400.0 -211000.0 -1.21 601650.0 -247000.0 -1.24 712530.0 -211790.9375 -1.16597263476357 693090.0 -270369.6875 -1.61326508526336 -2.6111 -0.9907 2072468 Maybridge1_005926 Fc1cccc(Cl)c1N/N=C\2/C(=O)ON=C2c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F09 compound treatment 641610.0 -229000.0 -1.31 564110.0 -285000.0 -1.42 689000.0 -235320.9375 -1.2955123422687 650980.0 -312479.6875 -1.8645306519347 -2.9462 -0.9879 2072469 Maybridge1_005927 FC(F)(F)c1cc(NC(=S)SCCSC(=S)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F10 compound treatment 759310.0 -111000.0 -0.64 661290.0 -188000.0 -0.94 781190.0 -143130.9375 -0.787978741125572 776020.0 -187439.6875 -1.11843123477525 -1.7401 -0.9795 2072470 Maybridge1_005928 Cc1onc(c1C(=O)Oc2c(Cl)cncc2Cl)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F11 compound treatment 771140.0 -99300.0 -0.57 610010.0 -239000.0 -1.2 769620.0 -154700.9375 -0.851675061390525 885010.0 -78449.6875 -0.468100336852929 -1.5413 -0.9388 2072471 Maybridge1_005929 Cc1ccc(OC(=O)/C=C/c2cccs2)c(c1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F12 compound treatment 706470.0 -164000.0 -0.94 623450.0 -226000.0 -1.13 691570.0 -232750.9375 -1.28136372143197 719130.0 -244329.6875 -1.45788737554781 -2.4021 -0.9875 2072472 Maybridge1_005930 CN(C)C(=O)Oc1noc2ccc(Cl)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F13 compound treatment 762830.0 -108000.0 -0.61 746400.0 -103000.0 -0.51 756060.0 -168260.9375 -0.926326928529051 807310.0 -156149.6875 -0.931727373907381 -1.4931 -0.9703 2072473 Maybridge1_005931 S=C1NC(C=C(N1)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F14 compound treatment 747570.0 -123000.0 -0.7 709510.0 -139000.0 -0.7 800390.0 -123930.9375 -0.682276982345358 876980.0 -86479.6875 -0.516014430901157 -1.299 -0.993 2072474 Maybridge1_005932 Cc1onc(c1NC(=O)O/N=C/c2ccccc2[N+](=O)[O-])c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F15 compound treatment 666720.0 -204000.0 -1.16 610210.0 -239000.0 -1.19 693820.0 -230500.9375 -1.26897679657491 695760.0 -267699.6875 -1.59733349982017 -2.6123 -0.9914 1663929 Maybridge1_005933 Cc1cc(C)c(C#N)c(OC(=O)c2c(F)cccc2F)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F16 compound treatment 718960.0 -152000.0 -0.87 672270.0 -177000.0 -0.88 736770.0 -187550.9375 -1.03252416430355 798010.0 -165449.6875 -0.987219413091504 -1.8846 -0.9973 2072475 Maybridge1_005934 CC(=N/N=C/1\SCC(=N1)c2ccc(Cl)cc2)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F17 compound treatment 547110.0 -323000.0 -1.85 556390.0 -293000.0 -1.46 551570.0 -372750.9375 -2.0521057125377 590960.0 -372499.6875 -2.22266314567997 -3.7927 -0.989 1393277 Maybridge1_005935 CSc1cccc(NC(=O)c2sc3nc(C)cc(C)c3c2N)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F18 compound treatment 734940.0 -136000.0 -0.77 714720.0 -134000.0 -0.67 829600.0 -94720.9375 -0.521467171201083 790990.0 -172469.6875 -1.02910695234662 -1.4982 -0.9708 1574754 Maybridge1_005936 Cc1nccc(O)c1OCc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F19 compound treatment 779900.0 -90600.0 -0.52 711600.0 -137000.0 -0.69 864650.0 -59670.9375 -0.328506408427826 895700.0 -67759.6875 -0.404314326220856 -0.9687 -0.9633 2072476 Maybridge1_005937 Nc1c(sc2nc(cc(c12)C(F)(F)F)c3cccs3)C(=O)c4ccc(Cl)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F20 compound treatment 731170.0 -139000.0 -0.8 627680.0 -221000.0 -1.11 774360.0 -149960.9375 -0.825579939691659 757040.0 -206419.6875 -1.23168272979834 -1.98 -0.983 1261435 Maybridge1_005938 NNC(=O)Cn1cc(Cl)c(=O)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F21 compound treatment 781530.0 -89000.0 -0.51 701400.0 -148000.0 -0.74 780750.0 -143570.9375 -0.790401073097619 766400.0 -197059.6875 -1.17583267745819 -1.6063 -0.9582 1237977 Maybridge1_005939 CCOC(=O)C1=C(C)NC(=O)NC1c2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F22 compound treatment 801460.0 -69000.0 -0.39 765680.0 -83300.0 -0.42 819900.0 -104420.9375 -0.574868580584837 824800.0 -138659.6875 -0.827366538925626 -1.1066 -0.9545 1652480 Maybridge1_005940 CC(=O)Nc1cccc(c1)c2cc(no2)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F23 mock treatment 786510.0 -84000.0 -0.48 766960.0 -82000.0 -0.41 920010.0 -4310.9375 -0.0237330039448741 902850.0 -60609.6875 -0.361651091794353 -0.6377 -0.8761 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 F24 mock treatment 815460.0 -55000.0 -0.31 781880.0 -67100.0 -0.34 821630.0 -102690.9375 -0.565344411694745 888250.0 -75209.6875 -0.448767626427493 -0.832 -0.9722 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G01 compound treatment 757330.0 -113000.0 -0.65 799360.0 -49600.0 -0.25 828420.0 -95900.9375 -0.527963425126117 864640.0 -98819.6875 -0.589645803323961 -1.0061 -0.9568 2072477 Maybridge1_005941 CCOc1ccc(/N=C/c2cccs2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G02 compound treatment 706400.0 -164000.0 -0.94 647740.0 -201000.0 -1.01 677370.0 -246950.9375 -1.35953898052984 669860.0 -293599.6875 -1.75187584550499 -2.5277 -0.9687 2072478 Maybridge1_005942 CC(=O)CCCNc1nc(cs1)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G03 compound treatment 765070.0 -105000.0 -0.6 742650.0 -106000.0 -0.53 744720.0 -179600.9375 -0.988757029808615 789710.0 -173749.6875 -1.03674456634185 -1.5798 -0.9618 1537010 Maybridge1_005943 CCOC(=O)n1c(=O)c2cc(C)ccc2[nH]c1=S 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G04 compound treatment 593220.0 -277000.0 -1.58 494830.0 -354000.0 -1.77 546990.0 -377330.9375 -2.07731998624673 571250.0 -392209.6875 -2.34027046743471 -3.8864 -0.9891 2072479 Maybridge1_005944 Oc1c(Cl)cc(Cl)cc1/C=N/NC(=S)NCC2CCCO2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G05 compound treatment 737180.0 -133000.0 -0.76 648410.0 -201000.0 -1.0 763230.0 -161090.9375 -0.886853927984565 800510.0 -162949.6875 -0.972302198257062 -1.8119 -0.9947 2072480 Maybridge1_005945 COc1ccc(cc1)C(=O)CC(Sc2ccccc2)c3ccc(cc3)C(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G06 compound treatment 760810.0 -110000.0 -0.63 683800.0 -165000.0 -0.83 722750.0 -201570.9375 -1.10970846941285 932090.0 -31369.6875 -0.187179347090721 -1.3748 -0.8984 2072481 Maybridge1_005946 Clc1ccc(/C=N/c2cccnc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G07 compound treatment 748190.0 -122000.0 -0.7 696130.0 -153000.0 -0.76 795840.0 -128480.9375 -0.707326097056294 808760.0 -154699.6875 -0.923075389303404 -1.5468 -0.9933 1395171 Maybridge1_005947 CC1C(OCCN1C(=O)CCC(=O)N2CCOC(C2C)c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G08 compound treatment 444590.0 -426000.0 -2.43 451520.0 -397000.0 -1.99 476900.0 -447420.9375 -2.46318645879388 531740.0 -431719.6875 -2.57602213067823 -4.73 -0.9955 2072482 Maybridge1_005948 [O-][N+](=O)/C=C/c1c([nH]c2ccccc12)c3ccc4ccccc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G09 compound treatment 667400.0 -203000.0 -1.16 644380.0 -205000.0 -1.02 708770.0 -215550.9375 -1.18667256252469 756640.0 -206819.6875 -1.23406948417185 -2.3021 -0.9977 2072483 Maybridge1_005949 [O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G10 compound treatment 705600.0 -165000.0 -0.94 661660.0 -187000.0 -0.94 714720.0 -209600.9375 -1.1539160279027 751010.0 -212449.6875 -1.26766305197901 -2.1502 -0.9914 2072484 Maybridge1_005950 CCCOc1ccccc1/C=N/NC(=S)Nc2ccc(C)c(C)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G11 compound treatment 775870.0 -94600.0 -0.54 730750.0 -118000.0 -0.59 778660.0 -145660.9375 -0.80190714996484 905240.0 -58219.6875 -0.347390234412626 -1.1406 -0.962 1019401 Maybridge1_005951 CCOC(=O)C(N)c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G12 compound treatment 918610.0 48100.0 0.27 649870.0 -199000.0 -1.0 733840.0 -190480.9375 -1.0486546931174 767680.0 -195779.6875 -1.16819506346295 -1.4689 -0.7816 1696641 Maybridge1_005952 Fc1cccc(Nc2ccccc2C(=O)OCC(=O)c3ccccc3)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G13 compound treatment 789490.0 -81000.0 -0.46 778240.0 -70800.0 -0.35 999150.0 74829.0625 0.411956433027323 775270.0 -188189.6875 -1.12290639922559 -0.7637 -0.5741 2072485 Maybridge1_005953 Cc1ccc2nsnc2c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G14 compound treatment 699040.0 -171000.0 -0.98 696180.0 -153000.0 -0.76 732840.0 -191480.9375 -1.05415999305387 1129700.0 166240.3125 0.991936982282896 -0.9029 -0.4734 2072486 Maybridge1_005954 Cc1onc(c1C(=O)OCC(=O)c2ccc(Cl)cc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G15 compound treatment 790400.0 -80100.0 -0.46 692500.0 -156000.0 -0.78 745330.0 -178990.9375 -0.985398796847369 773940.0 -189519.6875 -1.13084235751751 -1.6782 -0.9575 2072487 Maybridge1_005955 FC(F)(F)c1cc(Cl)c2nsnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G16 compound treatment 755930.0 -115000.0 -0.65 690950.0 -158000.0 -0.79 788230.0 -136090.9375 -0.749221429572827 812820.0 -150639.6875 -0.898849832412271 -1.5465 -0.9936 1032061 Maybridge1_005956 CSc1nc(O)cc(n1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G17 compound treatment 756280.0 -114000.0 -0.65 659310.0 -190000.0 -0.95 758480.0 -165840.9375 -0.913004102682795 782750.0 -180709.6875 -1.07827409244094 -1.7962 -0.9855 2072488 Maybridge1_005957 CCOC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G18 compound treatment 762830.0 -108000.0 -0.61 696650.0 -152000.0 -0.76 734930.0 -189390.9375 -1.04265391618665 898690.0 -64769.6875 -0.386473337278864 -1.403 -0.9469 1077975 Maybridge1_005958 COc1cc(CCC(=O)O)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G19 compound treatment 731380.0 -139000.0 -0.79 742280.0 -107000.0 -0.53 853080.0 -71240.9375 -0.392202728692779 893380.0 -70079.6875 -0.418157501587218 -1.0694 -0.9584 2072489 Maybridge1_005959 OC(=O)CCNC(=S)Nc1cccc(Cl)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G20 compound treatment 782270.0 -88200.0 -0.5 710720.0 -138000.0 -0.69 793390.0 -130930.9375 -0.720814081900644 689450.0 -274009.6875 -1.63498455006231 -1.7756 -0.8963 1065810 Maybridge1_005960 CNC(=S)NC1CCCCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G21 compound treatment 741330.0 -129000.0 -0.74 708030.0 -141000.0 -0.71 744610.0 -179710.9375 -0.989362612801627 810000.0 -153459.6875 -0.915676450745521 -1.6739 -0.99 2072490 Maybridge1_005961 Sc1nccn1c2cc(Cl)ccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G22 compound treatment 669280.0 -201000.0 -1.15 682530.0 -166000.0 -0.83 706170.0 -218150.9375 -1.20098634235952 767080.0 -196379.6875 -1.17177519502322 -2.1774 -0.9908 1310850 Maybridge1_005962 COc1ccc(CCNC(=S)Nc2ccc(Br)c(C)c2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G23 mock treatment 762630.0 -108000.0 -0.62 739680.0 -109000.0 -0.55 809210.0 -115110.9375 -0.633720236905696 941860.0 -21599.6875 -0.128882871517723 -0.9627 -0.9193 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 G24 mock treatment 872720.0 2240.0 0.01 911130.0 62100.0 0.31 941680.0 17359.0625 0.0955668456784204 805850.0 -157609.6875 -0.940439027370695 -0.2607 -0.2619 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H01 compound treatment 724420.0 -146000.0 -0.83 783040.0 -66000.0 -0.33 769540.0 -154780.9375 -0.852115485385442 838790.0 -124669.6875 -0.74388980471209 -1.3801 -0.9559 2072491 Maybridge1_005963 [O-][N+](=O)c1ccc(OCCCCOc2ccc(cc2)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H02 compound treatment 757800.0 -113000.0 -0.64 735680.0 -113000.0 -0.57 813360.0 -110960.9375 -0.610873242169348 798630.0 -164829.6875 -0.983519943812563 -1.4024 -0.9733 2072492 Maybridge1_005964 Clc1ccc(SC(=S)Nc2cc(Cl)ccc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H03 compound treatment 667000.0 -203000.0 -1.16 578940.0 -270000.0 -1.35 655700.0 -268620.9375 -1.47883883015313 680960.0 -282499.6875 -1.68564341164007 -2.8388 -0.9911 1085517 Maybridge1_005965 Nc1nc(N)nc(n1)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H04 compound treatment 755000.0 -115000.0 -0.66 607110.0 -242000.0 -1.21 657920.0 -266400.9375 -1.46661706429417 708190.0 -255269.6875 -1.52316510766333 -2.4296 -0.9627 2072493 Maybridge1_005966 Cc1onc(c1C#N)c2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H05 compound treatment 804730.0 -65800.0 -0.38 672220.0 -177000.0 -0.88 773020.0 -151300.9375 -0.832957041606528 773920.0 -189539.6875 -1.13096169523619 -1.6118 -0.9472 1698586 Maybridge1_005967 CC(Oc1ccc(Cl)cc1Cl)C(=O)Nc2c(C)cccc2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H06 compound treatment 750300.0 -120000.0 -0.69 666650.0 -182000.0 -0.91 762350.0 -161970.9375 -0.891698591928658 803390.0 -160069.6875 -0.955117566767785 -1.7227 -0.9929 1023952 Maybridge1_005968 O=C1CC(=NO1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H07 compound treatment 556130.0 -314000.0 -1.8 487310.0 -362000.0 -1.81 532560.0 -391760.9375 -2.15676146432999 485390.0 -478069.6875 -2.85258729370878 -4.307 -0.9807 1205192 Maybridge1_005969 Clc1ccc(Oc2ccc(NS(=O)(=O)c3ccccc3)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H08 compound treatment 678830.0 -192000.0 -1.09 573850.0 -275000.0 -1.38 691460.0 -232860.9375 -1.28196930442498 747360.0 -216099.6875 -1.2894421856373 -2.5212 -0.9967 2072494 Maybridge1_005970 FC(F)(F)c1cc(N/N=C\2/C(=O)ON=C2c3ccccc3)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H09 compound treatment 739600.0 -131000.0 -0.75 638120.0 -211000.0 -1.05 760510.0 -163810.9375 -0.901828343811762 1044360.0 80900.3125 0.482722936694391 -1.1107 -0.6738 2072495 Maybridge1_005971 [O-][N+](=O)c1ccc(cc1)c2cc3cc(Cl)ccc3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H10 compound treatment 718290.0 -152000.0 -0.87 584390.0 -265000.0 -1.32 332990.0 -591330.9375 -3.25545417265121 773440.0 -190019.6875 -1.1338258004844 -3.2911 -0.8675 2072496 Maybridge1_005972 CCOC(=O)c1c(Cl)c(nc(O)c1C#N)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H11 compound treatment 586930.0 -284000.0 -1.62 524930.0 -324000.0 -1.62 476450.0 -447870.9375 -2.46566384376529 611920.0 -351539.6875 -2.09759721650801 -3.9019 -0.9838 1540102 Maybridge1_005973 NCCSC(=S)NC1CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H12 compound treatment 875950.0 5470.0 0.03 665090.0 -184000.0 -0.92 713280.0 -211040.9375 -1.16184365981122 743060.0 -220399.6875 -1.31509979515253 -1.6828 -0.8492 2072497 Maybridge1_005974 CN(C)C(=O)Oc1noc2cc(Cl)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H13 compound treatment 728570.0 -142000.0 -0.81 773400.0 -75600.0 -0.38 987410.0 63089.0625 0.347324211773171 834050.0 -129409.6875 -0.772172844038191 -0.8068 -0.655 2072498 Maybridge1_005975 OC(=O)C1=Cc2cc(Cl)ccc2OC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H14 compound treatment 745930.0 -125000.0 -0.71 662450.0 -187000.0 -0.93 739680.0 -184640.9375 -1.01650374148842 776910.0 -186549.6875 -1.11312070629419 -1.8871 -0.9879 2072499 Maybridge1_005976 Cc1onc(c1NC(=O)O/N=C/c2ccccn2)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H15 compound treatment 702310.0 -168000.0 -0.96 584340.0 -265000.0 -1.32 674460.0 -249860.9375 -1.37555940334496 722010.0 -241449.6875 -1.44070274405853 -2.5503 -0.9895 1330733 Maybridge1_005977 Cc1cc(C)c(C#N)c(OC(=O)c2cccs2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H16 compound treatment 818150.0 -52300.0 -0.3 747870.0 -101000.0 -0.51 726240.0 -198080.9375 -1.09049497263457 795570.0 -167889.6875 -1.00177861476992 -1.4485 -0.9092 2072500 Maybridge1_005978 CCOC(=O)c1nnn(c1O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H17 compound treatment 726840.0 -144000.0 -0.82 611360.0 -238000.0 -1.19 736960.0 -187360.9375 -1.03147815731562 776670.0 -186789.6875 -1.1145527589183 -2.0776 -0.9913 1719106 Maybridge1_005979 Cc1cc(C)c2c(c(sc2n1)C(=O)c3ccc(Cl)cc3)n4cccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H18 compound treatment 742880.0 -128000.0 -0.73 651270.0 -198000.0 -0.99 723620.0 -200700.9375 -1.10491885846812 759750.0 -203709.6875 -1.2155124689178 -2.0191 -0.9843 2072501 Maybridge1_005980 [O-][N+](=O)c1ccc(C#N)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H19 compound treatment 678240.0 -192000.0 -1.1 764040.0 -85000.0 -0.42 709860.0 -214460.9375 -1.18067178559394 717780.0 -245679.6875 -1.46594267155841 -2.0848 -0.939 2072502 Maybridge1_005981 CC(=O)c1sc2nc(cc(c2c1N)C(F)(F)F)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H20 compound treatment 668610.0 -202000.0 -1.15 628330.0 -221000.0 -1.1 688040.0 -236280.9375 -1.30079743020771 711040.0 -252419.6875 -1.50615948275207 -2.5319 -0.9924 1604442 Maybridge1_005982 N#Cc1ccc(OCc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H21 compound treatment 415110.0 -455000.0 -2.6 353090.0 -496000.0 -2.48 448960.0 -475360.9375 -2.61700453901884 412960.0 -550499.6875 -3.28476884189223 -5.4917 -0.9935 2072503 Maybridge1_005983 Nc1ccccc1SC(C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H22 compound treatment 774560.0 -95900.0 -0.55 688110.0 -161000.0 -0.8 748590.0 -175730.9375 -0.967451519054478 778140.0 -185319.6875 -1.10578143659565 -1.7129 -0.9719 2072504 Maybridge1_005984 N/C(=N\O)/c1ccc(OCc2ccc(Cl)cc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H23 mock treatment 826330.0 -44200.0 -0.25 759680.0 -89300.0 -0.45 969230.0 44909.0625 0.247237858928156 910880.0 -52579.6875 -0.313736997746126 -0.3827 -0.5886 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 H24 mock treatment 859420.0 -11100.0 -0.06 813680.0 -35300.0 -0.18 1082370.0 158049.0625 0.870107493740317 1097530.0 134070.3125 0.799982261793299 0.7151 0.5976 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I01 compound treatment 763450.0 -107000.0 -0.61 829870.0 -19100.0 -0.1 856400.0 -67920.9375 -0.3739251329037 879120.0 -84339.6875 -0.503245295002874 -0.7921 -0.8992 2072505 Maybridge1_005985 Cc1ccc(/N=C/c2cccs2)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I02 compound treatment 730950.0 -140000.0 -0.8 682350.0 -167000.0 -0.83 782560.0 -141760.9375 -0.780436480212609 837860.0 -125599.6875 -0.749439008630502 -1.5802 -0.9993 1187362 Maybridge1_005986 Nc1cc(O)n(Cc2ccco2)c(=S)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I03 compound treatment 722600.0 -148000.0 -0.84 655640.0 -193000.0 -0.97 757760.0 -166560.9375 -0.916967918637053 777660.0 -185799.6875 -1.10864554184386 -1.9187 -0.995 2072506 Maybridge1_005987 CCOC(=O)NC(=S)NCCO 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I04 compound treatment 728960.0 -142000.0 -0.81 664960.0 -184000.0 -0.92 744810.0 -179510.9375 -0.988261552814333 762370.0 -201089.6875 -1.19987922777131 -1.9585 -0.9896 2072507 Maybridge1_005988 COc1ccc(/C=N/NC(=S)NCC2CCCO2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I05 compound treatment 754640.0 -116000.0 -0.66 660060.0 -189000.0 -0.94 744080.0 -180240.9375 -0.992280421767956 824990.0 -138469.6875 -0.826232830598208 -1.7126 -0.9891 1524757 Maybridge1_005989 Clc1ccc2c(=O)[nH]c(=O)[nH]c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I06 compound treatment 744980.0 -126000.0 -0.72 681700.0 -167000.0 -0.84 795890.0 -128430.9375 -0.70705083205947 793470.0 -169989.6875 -1.01430907523085 -1.6375 -0.9887 2072508 Maybridge1_005990 CSc1cccc(NC(=O)/C=C/C(=O)O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I07 compound treatment 748060.0 -122000.0 -0.7 665080.0 -184000.0 -0.92 830200.0 -94120.9375 -0.518163991239201 803040.0 -160419.6875 -0.957205976844607 -1.5473 -0.9747 1089852 Maybridge1_005991 ON1C(=O)C2C3OC(C=C3)C2C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I08 compound treatment 713820.0 -157000.0 -0.89 673890.0 -175000.0 -0.88 804030.0 -120290.9375 -0.662237690576609 758300.0 -205159.6875 -1.22416445352178 -1.8286 -0.9767 2072509 Maybridge1_005992 C/C(=N\Nc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-])/c2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I09 compound treatment 754320.0 -116000.0 -0.66 654330.0 -195000.0 -0.97 808570.0 -115750.9375 -0.637243628865037 806150.0 -157309.6875 -0.938648961590562 -1.6065 -0.9822 1446187 Maybridge1_005993 COC(=O)c1ccc(NC(=O)C)c(NC(=O)C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I10 compound treatment 767520.0 -103000.0 -0.59 623360.0 -226000.0 -1.13 731200.0 -193120.9375 -1.06318868494968 814260.0 -149199.6875 -0.890257516667633 -1.8351 -0.975 2072510 Maybridge1_005994 CCCOc1ccccc1/C=N/NC(=S)Nc2cc(Cl)ccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I11 compound treatment 724320.0 -146000.0 -0.83 782400.0 -66600.0 -0.33 846150.0 -78170.9375 -0.430354457252512 802570.0 -160889.6875 -0.960010413233482 -1.2792 -0.9244 2072511 Maybridge1_005995 COC(=O)c1ccc2[nH]nnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I12 compound treatment 828320.0 -42200.0 -0.24 671930.0 -177000.0 -0.89 753650.0 -170670.9375 -0.939594701375943 772590.0 -190869.6875 -1.13889765352811 -1.6025 -0.9218 1147787 Maybridge1_005996 O=C(COC(=O)c1ccccc1NCc2ccco2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I13 compound treatment 742260.0 -128000.0 -0.73 934620.0 85600.0 0.43 763740.0 -160580.9375 -0.884046225016965 833970.0 -129489.6875 -0.772650194912893 -0.9804 -0.6768 1005880 Maybridge1_005997 [O-][N+](=O)C1C(=O)NC(=O)NC1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I14 compound treatment 730320.0 -140000.0 -0.8 686600.0 -162000.0 -0.81 932000.0 7679.0625 0.0422755422933954 982290.0 18830.3125 0.11235832678487 -0.7291 -0.6358 1242165 Maybridge1_005998 O=C(COC(=O)c1ccccc1C(=O)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I15 compound treatment 752040.0 -118000.0 -0.68 726300.0 -123000.0 -0.61 729490.0 -194830.9375 -1.07260274784105 828800.0 -134659.6875 -0.803498995190519 -1.5832 -0.9761 1040518 Maybridge1_005999 Cc1cc2nc(C)c(C)nc2cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I16 compound treatment 670450.0 -200000.0 -1.14 619420.0 -230000.0 -1.15 713300.0 -211020.9375 -1.16173355381249 762580.0 -200879.6875 -1.19862618172521 -2.3256 -0.9998 1590570 Maybridge1_006000 COc1cccc(C2NC(=O)c3ccccc3N2)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I17 compound treatment 731840.0 -139000.0 -0.79 705920.0 -143000.0 -0.72 790900.0 -133420.9375 -0.734522278742453 790640.0 -172819.6875 -1.03119536242344 -1.6367 -0.9883 1351125 Maybridge1_006001 CC(=O)Nc1ccc(cc1NC(=O)C)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I18 compound treatment 774150.0 -96300.0 -0.55 713440.0 -136000.0 -0.68 756530.0 -167790.9375 -0.923739437558911 860930.0 -102529.6875 -0.611782950138273 -1.3819 -0.9796 2072512 Maybridge1_006002 Cc1cc(C)c(NC(=N)NC(=N)NN)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I19 compound treatment 761930.0 -109000.0 -0.62 701790.0 -147000.0 -0.74 738300.0 -186020.9375 -1.02410105540075 784960.0 -178499.6875 -1.06508727452729 -1.7228 -0.9769 1428290 Maybridge1_006003 OC(=O)CCNC(=S)Nc1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I20 compound treatment 681370.0 -189000.0 -1.08 665290.0 -184000.0 -0.92 702190.0 -222130.9375 -1.22289743610666 745990.0 -217469.6875 -1.29761681936657 -2.2598 -0.9919 2072513 Maybridge1_006004 C/N=C(/NC1CCCCC1)\SCc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I21 compound treatment 578140.0 -292000.0 -1.67 558140.0 -291000.0 -1.45 592570.0 -331750.9375 -1.82638841514245 650090.0 -313369.6875 -1.86984118041576 -3.4105 -0.9955 2072514 Maybridge1_006005 COCCC[n+]1c(C)csc1Nc2c(C)cc(C)cc2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I22 compound treatment 566300.0 -304000.0 -1.74 535380.0 -314000.0 -1.57 578010.0 -346310.9375 -1.90654558221745 809070.0 -154389.6875 -0.921225654663934 -3.067 -0.9716 2072515 Maybridge1_006006 CC[n+]1c(C)csc1Nc2c(C)cccc2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I23 mock treatment 771010.0 -99500.0 -0.57 743870.0 -105000.0 -0.53 952920.0 28599.0625 0.157446416964338 868700.0 -94759.6875 -0.565420246432828 -0.751 -0.773 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 I24 mock treatment 790800.0 -79700.0 -0.46 816540.0 -32500.0 -0.16 1021250.0 96929.0625 0.5336235616233 1161250.0 197790.3125 1.18019223349355 0.5482 0.3965 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J01 compound treatment 290470.0 -580000.0 -3.31 242360.0 -607000.0 -3.03 234260.0 -690060.9375 -3.79899243537884 275680.0 -687779.6875 -4.1039029428811 -7.1252 -0.9933 2072516 Maybridge1_006007 CCOC(=O)c1ccc(cc1)c2ccc(/C=N/NC(=S)Nc3ccc(OC)cc3)o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J02 compound treatment 810050.0 -60400.0 -0.35 738560.0 -110000.0 -0.55 803780.0 -120540.9375 -0.663614015560726 763440.0 -200019.6875 -1.19349465982217 -1.3773 -0.9104 2072517 Maybridge1_006008 FC(F)(F)c1ccc(Cl)c(NC(=S)Sc2ccc(Cl)cc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J03 compound treatment 740160.0 -130000.0 -0.74 713220.0 -136000.0 -0.68 816400.0 -107920.9375 -0.594137130362481 865280.0 -98179.6875 -0.585826996326344 -1.3018 -0.995 2072518 Maybridge1_006009 OC(=O)c1cc(ccc1NCc2ccco2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J04 compound treatment 556640.0 -314000.0 -1.79 560110.0 -289000.0 -1.44 626130.0 -298190.9375 -1.64163054927454 662500.0 -300959.6875 -1.79579212597759 -3.3376 -0.9963 2072519 Maybridge1_006010 Cc1onc(c1C(=O)N)c2c(F)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J05 compound treatment 679630.0 -191000.0 -1.09 721280.0 -128000.0 -0.64 754150.0 -170170.9375 -0.936842051407708 816970.0 -146489.6875 -0.874087255787098 -1.77 -0.9836 1724484 Maybridge1_006011 CC(Oc1ccc(Cl)cc1Cl)C(=O)Nc2ccc(Cl)cc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J06 compound treatment 650150.0 -220000.0 -1.26 688850.0 -160000.0 -0.8 767400.0 -156920.9375 -0.863896827249487 718200.0 -245259.6875 -1.46343657946622 -2.1935 -0.97 2072520 Maybridge1_006012 O/N=C\1/C(=O)ON=C1c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J07 compound treatment 733190.0 -137000.0 -0.78 624000.0 -225000.0 -1.13 725850.0 -198470.9375 -1.0926420396098 778750.0 -184709.6875 -1.10214163617604 -2.0522 -0.9908 2072521 Maybridge1_006013 COc1ccc(OS(=O)(=O)c2ccc(NC(=O)C)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J08 compound treatment 75360.0 -795000.0 -4.54 146660.0 -702000.0 -3.51 66500.0 -857820.9375 -4.72256155272097 89350.0 -874109.6875 -5.21571279892172 -8.9966 -0.9906 2072522 Maybridge1_006014 CN(C)/C=N/c1nonc1c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J09 compound treatment 875740.0 5260.0 0.03 619200.0 -230000.0 -1.15 788500.0 -135820.9375 -0.74773499858998 789620.0 -173839.6875 -1.03728158607589 -1.4522 -0.8445 2072523 Maybridge1_006015 FC(F)(F)c1cc(NC(=O)CN2CCOCC2)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J10 compound treatment 784120.0 -86400.0 -0.49 658260.0 -191000.0 -0.95 802720.0 -121600.9375 -0.669449633493384 812640.0 -150819.6875 -0.899923871880351 -1.5083 -0.9713 2072524 Maybridge1_006016 Nc1c(Cl)cncc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J11 compound treatment 719130.0 -151000.0 -0.86 630950.0 -218000.0 -1.09 721680.0 -202640.9375 -1.11559914034487 984170.0 20710.3125 0.12357607234037 -1.4736 -0.8242 2072525 Maybridge1_006017 Cc1cccc(C)c1N=C2SCCS2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J12 compound treatment 835520.0 -35000.0 -0.2 652660.0 -196000.0 -0.98 763440.0 -160880.9375 -0.885697814997906 755240.0 -208219.6875 -1.24242312447913 -1.6549 -0.9066 2072526 Maybridge1_006018 CN(C)C(=O)Oc1noc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J13 compound treatment 915380.0 44900.0 0.26 593250.0 -256000.0 -1.28 672900.0 -251420.9375 -1.38414767124586 680800.0 -282659.6875 -1.68659811338947 -2.0467 -0.8051 1462709 Maybridge1_006019 Cc1cc(=O)[nH]c(n1)c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J14 compound treatment 750530.0 -120000.0 -0.69 850350.0 1350.0 0.01 832660.0 -91660.9375 -0.504620953395486 976960.0 13500.3125 0.08055482475784 -0.5513 -0.6449 2072527 Maybridge1_006020 Cc1onc(c1NC(=O)O/N=C/c2cccnc2)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J15 compound treatment 681720.0 -189000.0 -1.08 646120.0 -203000.0 -1.01 759720.0 -164600.9375 -0.906177530761573 774160.0 -189299.6875 -1.12952964261208 -2.0643 -0.9968 2072528 Maybridge1_006021 Clc1cc(Cl)c(NC(=O)C(Cl)(Cl)Cl)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J16 compound treatment 737770.0 -133000.0 -0.76 735410.0 -114000.0 -0.57 742830.0 -181490.9375 -0.999162046688543 834200.0 -129259.6875 -0.771277811148125 -1.5483 -0.9811 1029309 Maybridge1_006022 CC(=O)Nc1ccc(cc1)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J17 compound treatment 725330.0 -145000.0 -0.83 714080.0 -135000.0 -0.67 793280.0 -131040.9375 -0.721419664893656 863590.0 -99869.6875 -0.595911033554427 -1.4106 -0.9929 2072529 Maybridge1_006023 COc1nc(C)cc(C)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J18 compound treatment 747080.0 -123000.0 -0.7 722040.0 -127000.0 -0.63 949060.0 24739.0625 0.136195959209565 772000.0 -191459.6875 -1.14241811622904 -1.1731 -0.7866 2072530 Maybridge1_006024 CC(C)(C)c1ccc(NC(=O)c2ccco2)c(NC(=O)C(Cl)Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J19 compound treatment 469720.0 -401000.0 -2.29 489300.0 -360000.0 -1.8 533280.0 -391040.9375 -2.15279764837573 628110.0 -335349.6875 -2.00099333324017 -4.1211 -0.9961 2072531 Maybridge1_006025 FC(F)(F)c1cc(NC(=O)C(Sc2ccc(Cl)cc2)c3ccccc3)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J20 compound treatment 762950.0 -108000.0 -0.61 605150.0 -244000.0 -1.22 798530.0 -125790.9375 -0.692516840227191 836500.0 -126959.6875 -0.757553973500438 -1.642 -0.9612 1095814 Maybridge1_006026 Oc1nc(nc(n1)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J21 compound treatment 736320.0 -134000.0 -0.77 646990.0 -202000.0 -1.01 815000.0 -109320.9375 -0.601844550273538 804320.0 -159139.6875 -0.949568362849373 -1.6641 -0.9819 1782371 Maybridge1_006027 CCOC(=O)C1=C(C)NC(=O)NC1c2cccc(c2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J22 compound treatment 747970.0 -123000.0 -0.7 676680.0 -172000.0 -0.86 734430.0 -189890.9375 -1.04540656615489 794170.0 -169289.6875 -1.01013225507721 -1.8086 -0.9888 1679639 Maybridge1_006028 Clc1ccc(cc1)C(=O)CSC(=S)N2CCOCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J23 mock treatment 792320.0 -78200.0 -0.45 826470.0 -22500.0 -0.11 801440.0 -122880.9375 -0.676496417412065 876080.0 -87379.6875 -0.521384628241556 -0.8785 -0.9054 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 J24 mock treatment 818290.0 -52200.0 -0.3 830040.0 -19000.0 -0.09 1063680.0 139359.0625 0.767213437927701 1091130.0 127670.3125 0.761794191817128 0.568 0.5047 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K01 compound treatment 525840.0 -345000.0 -1.97 524240.0 -325000.0 -1.62 561650.0 -362670.9375 -1.99661228917809 552070.0 -411389.6875 -2.45471533964455 -4.0222 -0.9894 2072532 Maybridge1_006029 Oc1ccc(/N=C/c2cccs2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K02 compound treatment 667200.0 -203000.0 -1.16 564370.0 -285000.0 -1.42 710850.0 -213470.9375 -1.17522153865684 684810.0 -278649.6875 -1.66267090079503 -2.7114 -0.9887 2072533 Maybridge1_006030 CC(C)(C)NC(=S)N/N=C/c1cccnc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K03 compound treatment 655160.0 -215000.0 -1.23 593050.0 -256000.0 -1.28 670950.0 -253370.9375 -1.39488300612197 688770.0 -274689.6875 -1.63904203249727 -2.772 -0.9936 2072534 Maybridge1_006031 C=CCN(CC=C)C(=S)NC(=O)c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K04 compound treatment 677030.0 -193000.0 -1.11 599280.0 -250000.0 -1.25 659700.0 -264620.9375 -1.45681763040725 688180.0 -275279.6875 -1.6425624951982 -2.7267 -0.989 2072535 Maybridge1_006032 COc1cc(/C=N/NC(=S)NCC2CCCO2)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K05 compound treatment 801630.0 -68900.0 -0.39 695470.0 -154000.0 -0.77 817080.0 -107240.9375 -0.590393526405681 829600.0 -133859.6875 -0.798725486443498 -1.2751 -0.9692 2072536 Maybridge1_006033 COc1ccc(OC)c(NC2=NCCS2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K06 compound treatment 249340.0 -621000.0 -3.55 266670.0 -582000.0 -2.91 186310.0 -738010.9375 -4.06297156733256 305400.0 -658059.6875 -3.92656709292925 -7.2252 -0.9925 2072537 Maybridge1_006034 Clc1cccc(NC(=S)N/N=C/c2ccccc2Cl)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K07 compound treatment 810080.0 -60400.0 -0.35 703770.0 -145000.0 -0.73 813120.0 -111200.9375 -0.612194514154101 838240.0 -125219.6875 -0.747171591975667 -1.2154 -0.967 1697868 Maybridge1_006035 O=C(ON1C(=O)C2C3OC(C=C3)C2C1=O)Oc4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K08 compound treatment 766330.0 -104000.0 -0.59 727750.0 -121000.0 -0.61 808760.0 -115560.9375 -0.636197621877108 820580.0 -142879.6875 -0.852546797566164 -1.3451 -0.988 2072538 Maybridge1_006036 Cc1ccc(C2N=NNC2=S)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K09 compound treatment 781810.0 -88700.0 -0.51 678080.0 -171000.0 -0.85 824500.0 -99820.9375 -0.549544200877078 822980.0 -140479.6875 -0.8382262713251 -1.3746 -0.9739 2072539 Maybridge1_006037 Fc1ccc2nsnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K10 compound treatment 761760.0 -109000.0 -0.62 657770.0 -191000.0 -0.96 859640.0 -64680.9375 -0.356087961109539 792980.0 -170479.6875 -1.0172328493384 -1.4754 -0.9403 1603 Maybridge1_006038 OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K11 compound treatment 867620.0 -2860.0 -0.02 682800.0 -166000.0 -0.83 816710.0 -107610.9375 -0.592430487382175 781290.0 -182169.6875 -1.08698574590425 -1.2635 -0.8473 2072540 Maybridge1_006039 FC(F)(F)c1ccc2nsnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K12 compound treatment 763290.0 -107000.0 -0.61 694140.0 -155000.0 -0.77 928850.0 4529.0625 0.0249338474935165 870480.0 -92979.6875 -0.554799189470705 -0.9584 -0.846 1228269 Maybridge1_006040 Oc1ccccc1C(=O)Nc2ccc(NC(=S)NCCc3ccccc3)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K13 compound treatment 710340.0 -160000.0 -0.91 679040.0 -170000.0 -0.85 1059740.0 135419.0625 0.745522556178011 944720.0 -18739.6875 -0.111817577747121 -0.5656 -0.3877 2072541 Maybridge1_006041 CC(C)(C)C(=O)Nc1cccc(Cl)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K14 compound treatment 864850.0 -5630.0 -0.03 686640.0 -162000.0 -0.81 799370.0 -124950.9375 -0.687892388280556 809660.0 -153799.6875 -0.917705191963005 -1.2249 -0.8714 1437700 Maybridge1_006042 Nc1cccc(NC(=O)c2ccccc2O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K15 compound treatment 748510.0 -122000.0 -0.7 636680.0 -212000.0 -1.06 743480.0 -180840.9375 -0.995583601729838 821310.0 -142149.6875 -0.848190970834507 -1.8012 -0.988 2072542 Maybridge1_006043 COC(=O)c1ccc2nc(C)c(C)nc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K16 compound treatment 411430.0 -459000.0 -2.62 390950.0 -458000.0 -2.29 401770.0 -522550.9375 -2.87679964302084 434280.0 -529179.6875 -3.15755483378411 -5.4738 -0.9933 1579367 Maybridge1_006044 Oc1cccc(C(=O)OCC(=O)c2ccc(Cl)cc2)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K17 compound treatment 802520.0 -68000.0 -0.39 663520.0 -185000.0 -0.93 739210.0 -185110.9375 -1.01909123245856 768710.0 -194749.6875 -1.16204917095116 -1.7485 -0.9482 2072543 Maybridge1_006045 CCC(=O)Oc1ccc(NC(=S)NCCCO)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K18 compound treatment 858360.0 -12100.0 -0.07 692400.0 -157000.0 -0.78 812350.0 -111970.9375 -0.616433595105182 836600.0 -126859.6875 -0.75695728490706 -1.1129 -0.8879 2072544 Maybridge1_006046 NNC(=N)NC(=N)Nc1cccc(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K19 compound treatment 645210.0 -225000.0 -1.29 642670.0 -206000.0 -1.03 664170.0 -260150.9375 -1.43220893969124 700710.0 -262749.6875 -1.56779741444798 -2.6594 -0.989 2072545 Maybridge1_006047 Clc1ccc(NC(=S)NCc2ccco2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K20 compound treatment 804260.0 -66200.0 -0.38 682580.0 -166000.0 -0.83 803120.0 -121200.9375 -0.667247513518796 950720.0 -12739.6875 -0.0760162621444611 -0.9769 -0.8612 2072546 Maybridge1_006048 Cc1csc(NC2CCCCC2)[n+]1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K21 compound treatment 741860.0 -129000.0 -0.73 628610.0 -220000.0 -1.1 780400.0 -143920.9375 -0.792327928075383 784250.0 -179209.6875 -1.06932376354027 -1.8493 -0.9848 2072547 Maybridge1_006049 FC(F)(F)c1cc(/N=C/2\NCCN/C(=N/c3cc(cc(c3)C(F)(F)F)C(F)(F)F)/SS2)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K22 compound treatment 648320.0 -222000.0 -1.27 541760.0 -307000.0 -1.54 685120.0 -239200.9375 -1.3168729060222 827040.0 -136419.6875 -0.814000714433966 -2.4683 -0.9781 2072548 Maybridge1_006050 Cc1csc(Nc2ccc(C)cc2C)[n+]1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K23 mock treatment 798320.0 -72200.0 -0.41 707450.0 -142000.0 -0.71 854200.0 -70120.9375 -0.386036792763933 959960.0 -3499.6875 -0.0208822361163642 -0.7635 -0.8429 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 K24 mock treatment 998300.0 128000.0 0.73 864720.0 15700.0 0.08 820690.0 -103630.9375 -0.570519393635026 1100610.0 137150.3125 0.818360270469332 0.5283 0.4265 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L01 compound treatment 758360.0 -112000.0 -0.64 716430.0 -133000.0 -0.66 1006940.0 82619.0625 0.454842719532421 822560.0 -140899.6875 -0.840732363417286 -0.8447 -0.6361 1088868 Maybridge1_006051 Nc1nc(N)nc(n1)c2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L02 compound treatment 872880.0 2400.0 0.01 770320.0 -78700.0 -0.39 796750.0 -127570.9375 -0.702316274114107 823230.0 -140229.6875 -0.836734549841655 -0.9594 -0.8262 2072549 Maybridge1_006052 Cc1onc(c1CO)c2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L03 compound treatment 807050.0 -63400.0 -0.36 674930.0 -174000.0 -0.87 771200.0 -153120.9375 -0.842976687490903 768230.0 -195229.6875 -1.16491327619938 -1.6204 -0.9423 2072550 Maybridge1_006053 OC(=O)c1cc(ccc1NCCc2ccccc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L04 compound treatment 731870.0 -139000.0 -0.79 605690.0 -243000.0 -1.22 751290.0 -173030.9375 -0.952587209226011 768160.0 -195299.6875 -1.16533095821474 -2.0633 -0.9867 1015353 Maybridge1_006054 CCOC(=O)c1cc(C)nc(O)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L05 compound treatment 708580.0 -162000.0 -0.92 607320.0 -242000.0 -1.21 708410.0 -215910.9375 -1.18865447050182 720190.0 -243269.6875 -1.45156247645801 -2.3869 -0.988 1192699 Maybridge1_006055 CC(Oc1ccc(I)cc1)C(=O)Nc2ccc(Br)cc2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L06 compound treatment 753970.0 -117000.0 -0.67 724860.0 -124000.0 -0.62 836920.0 -87400.9375 -0.481168375666126 857400.0 -106059.6875 -0.632846057484505 -1.2002 -0.9932 2072551 Maybridge1_006056 CNC(=O)O/N=C(\N)/c1c(C)onc1c2c(F)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L07 compound treatment 840260.0 -30200.0 -0.17 693670.0 -155000.0 -0.78 740080.0 -184240.9375 -1.01430162151383 845760.0 -117699.6875 -0.702300609753666 -1.3331 -0.908 2072552 Maybridge1_006057 Clc1ccc(cc1)c2[nH]c3ccccc3c2/C=N/NC(=S)NCCc4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L08 compound treatment 790880.0 -79600.0 -0.45 714120.0 -135000.0 -0.67 811970.0 -112350.9375 -0.618525609081041 829510.0 -133949.6875 -0.799262506177537 -1.2735 -0.9816 1199365 Maybridge1_006058 CCOC(=O)c1cc(nc(O)c1C#N)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L09 compound treatment 717500.0 -153000.0 -0.87 786610.0 -62400.0 -0.31 875490.0 -48830.9375 -0.268828957116497 794250.0 -169209.6875 -1.0096549042025 -1.2322 -0.8818 2072553 Maybridge1_006059 FC(F)(F)c1cc(NC(=O)CN2CCCCC2)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L10 compound treatment 699410.0 -171000.0 -0.98 625930.0 -223000.0 -1.12 696570.0 -227750.9375 -1.25383722174962 718430.0 -245029.6875 -1.46206419570146 -2.4044 -0.9891 2072554 Maybridge1_006060 Cc1onc(c1C(=O)NNc2c(Cl)cncc2Cl)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L11 compound treatment 791520.0 -79000.0 -0.45 642590.0 -206000.0 -1.03 734750.0 -189570.9375 -1.04364487017522 728210.0 -235249.6875 -1.40370805126912 -1.9654 -0.9446 2072555 Maybridge1_006061 OC(c1cccc(c1)[N+](=O)[O-])C(Cl)(Cl)Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L12 compound treatment 732320.0 -138000.0 -0.79 723230.0 -126000.0 -0.63 795680.0 -128640.9375 -0.708206945046129 772890.0 -190569.6875 -1.13710758774798 -1.6318 -0.9729 2072556 Maybridge1_006062 Cc1onc(c1NC(=O)O/N=C/c2ccc(Cl)c(Cl)c2)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L13 compound treatment 140670.0 -730000.0 -4.17 114280.0 -735000.0 -3.67 129120.0 -795200.9375 -4.37781967069925 143520.0 -819939.6875 -4.89248658788903 -8.557 -0.9948 2072557 Maybridge1_006063 Cc1nc(nc(S)c1Cl)c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L14 compound treatment 667720.0 -203000.0 -1.16 646910.0 -202000.0 -1.01 971890.0 47569.0625 0.261881956759164 836890.0 -126569.6875 -0.755226887986265 -1.3312 -0.7683 1616538 Maybridge1_006064 CNC(=O)Oc1noc2ccc(Cl)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L15 compound treatment 699360.0 -171000.0 -0.98 711960.0 -137000.0 -0.69 718340.0 -205980.9375 -1.13398684213268 759840.0 -203619.6875 -1.21497544918376 -2.0059 -0.9803 1104196 Maybridge1_006065 CCOC(=O)c1sc2nc(C)cc(C)c2c1N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L16 compound treatment 776990.0 -93500.0 -0.53 711630.0 -137000.0 -0.69 784860.0 -139460.9375 -0.767774290358729 832640.0 -130819.6875 -0.780586153204816 -1.3847 -0.9901 1294656 Maybridge1_006066 COC(=O)COc1c(C)nccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L17 compound treatment 461990.0 -408000.0 -2.33 426850.0 -422000.0 -2.11 483090.0 -441230.9375 -2.42910865218713 476050.0 -487409.6875 -2.90831800833026 -4.8912 -0.993 2072558 Maybridge1_006067 Cc1cc(C)c(C#N)c(SC(=O)c2c(F)cccc2F)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L18 compound treatment 773560.0 -96900.0 -0.55 710140.0 -139000.0 -0.69 838250.0 -86070.9375 -0.473846326750622 924800.0 -38659.6875 -0.230677945547954 -0.9763 -0.9454 2072559 Maybridge1_006068 CCOC(=O)c1ccc(OCc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L19 compound treatment 676120.0 -194000.0 -1.11 676960.0 -172000.0 -0.86 683770.0 -240550.9375 -1.32430506093643 742980.0 -220479.6875 -1.31557714602724 -2.3053 -0.9868 2072560 Maybridge1_006069 FC(F)(F)c1cc(NC(=O)C(Sc2ccccn2)c3ccccc3)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L20 compound treatment 711760.0 -159000.0 -0.91 741390.0 -108000.0 -0.54 957950.0 33629.0625 0.185138075644779 1007320.0 43860.3125 0.261709481707301 -0.499 -0.4528 1203411 Maybridge1_006070 Clc1ccc(COc2ccc(C#N)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L21 compound treatment 761780.0 -109000.0 -0.62 678240.0 -171000.0 -0.85 768680.0 -155640.9375 -0.856850043330806 821680.0 -141779.6875 -0.845983223039009 -1.5889 -0.9921 1192282 Maybridge1_006071 CCOC(=O)C1=C(C)NC(=O)NC1c2cccc(OC)c2O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L22 compound treatment 42100.0 -828000.0 -4.73 38400.0 -811000.0 -4.05 42080.0 -882240.9375 -4.85700097716956 43520.0 -919939.6875 -5.4891751812667 -9.5663 -0.9944 2072561 Maybridge1_006072 CS/C(=N\C#N)/NCc1cccnc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L23 mock treatment 806560.0 -63900.0 -0.37 684440.0 -165000.0 -0.82 843780.0 -80540.9375 -0.443402018101945 842760.0 -120699.6875 -0.720201267554996 -1.1759 -0.9519 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 L24 mock treatment 979220.0 109000.0 0.62 866330.0 17300.0 0.09 773090.0 -151230.9375 -0.832571670610975 859160.0 -104299.6875 -0.622344338241058 -0.3735 -0.3077 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M01 compound treatment 930600.0 60100.0 0.34 899760.0 50800.0 0.25 975840.0 51519.0625 0.283627891508219 981120.0 17660.3125 0.105377070242351 0.4932 0.9422 2072562 Maybridge1_006073 Sc1nnc(Nc2ccccc2Cl)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M02 compound treatment 671920.0 -199000.0 -1.13 529070.0 -320000.0 -1.6 555750.0 -368570.9375 -2.02909355880326 577130.0 -386329.6875 -2.30518517814411 -3.5343 -0.9699 1539962 Maybridge1_006074 CC(NC(=S)Nc1ccc(Oc2ccc(Cl)cc2)cc1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M03 compound treatment 710510.0 -160000.0 -0.91 706730.0 -142000.0 -0.71 806170.0 -118150.9375 -0.650456348712564 800640.0 -162819.6875 -0.971526503085671 -1.6237 -0.9866 2072563 Maybridge1_006075 O=C(NC(=S)NCc1ccncc1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M04 compound treatment 615410.0 -255000.0 -1.46 556520.0 -292000.0 -1.46 623960.0 -300360.9375 -1.65357705013667 598960.0 -364499.6875 -2.17492805820976 -3.3742 -0.9853 2072564 Maybridge1_006076 COc1ccc(cc1)/C(=C/c2cc(OC)c(OC)c(OC)c2)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M05 compound treatment 803220.0 -67300.0 -0.38 659630.0 -189000.0 -0.95 763330.0 -160990.9375 -0.886303397990918 911290.0 -52169.6875 -0.311290574513277 -1.2645 -0.9109 1083150 Maybridge1_006077 COc1cccc(NC(=S)NC(=O)c2ccccc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M06 compound treatment 783360.0 -87100.0 -0.5 787520.0 -61500.0 -0.31 976970.0 52649.0625 0.28984888043643 917730.0 -45729.6875 -0.272863829099755 -0.3941 -0.5569 1121329 Maybridge1_006078 OC(=O)CCC(=O)Nc1cccc(Cl)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M07 compound treatment 809840.0 -60600.0 -0.35 696970.0 -152000.0 -0.76 780770.0 -143550.9375 -0.790290967098889 760730.0 -202729.6875 -1.2096649207027 -1.5534 -0.9306 1107198 Maybridge1_006079 CCOC(=O)c1cncc(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M08 compound treatment 640610.0 -230000.0 -1.31 682400.0 -167000.0 -0.83 748870.0 -175450.9375 -0.965910035072267 759080.0 -204379.6875 -1.21951028249343 -2.1659 -0.9846 2072565 Maybridge1_006080 COc1cccc(/N=C/c2cc(OC)c(OC)c(OC)c2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M09 compound treatment 742610.0 -128000.0 -0.73 724860.0 -124000.0 -0.62 848080.0 -76240.9375 -0.419729228375126 854650.0 -108809.6875 -0.649254993802391 -1.2102 -0.9826 2072566 Maybridge1_006081 COC(=O)c1ccc2nccnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M10 compound treatment 672910.0 -198000.0 -1.13 642880.0 -206000.0 -1.03 759360.0 -164960.9375 -0.908159438738702 804740.0 -158719.6875 -0.947062270757187 -2.0074 -0.9965 2072567 Maybridge1_006082 Cc1cccc(C)c1n2nnnc2SCc3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M11 compound treatment 754920.0 -116000.0 -0.66 744870.0 -104000.0 -0.52 972270.0 47949.0625 0.263973970735023 1003290.0 39830.3125 0.237662931394181 -0.3396 -0.3721 2072568 Maybridge1_006083 Cc1cc2nsnc2cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M12 compound treatment 858660.0 -11800.0 -0.07 651320.0 -198000.0 -0.99 723380.0 -200940.9375 -1.10624013045288 827000.0 -136459.6875 -0.814239389871317 -1.4883 -0.8787 1334594 Maybridge1_006084 Oc1ccccc1C(=O)Nc2ccc(NC(=S)Nc3cccc(Cl)c3Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M13 compound treatment 767420.0 -103000.0 -0.59 728390.0 -121000.0 -0.6 839910.0 -84410.9375 -0.464707528856082 997350.0 33890.3125 0.202219628947547 -0.7272 -0.7394 1653923 Maybridge1_006085 CC1(C)C2CCC1(C)C(N)C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M14 compound treatment 742400.0 -128000.0 -0.73 715650.0 -133000.0 -0.67 693470.0 -230850.9375 -1.27090365155268 925160.0 -38299.6875 -0.228529866611794 -1.449 -0.8905 2072569 Maybridge1_006086 CCCc1c(C)nc2scc(c3ccccc3)n2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M15 compound treatment 746810.0 -124000.0 -0.71 703490.0 -146000.0 -0.73 759300.0 -165020.9375 -0.90848975673489 760900.0 -202559.6875 -1.20865055009396 -1.7757 -0.9753 1015121 Maybridge1_006087 CCOC(=O)CNC(=O)c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M16 compound treatment 860700.0 -9780.0 -0.06 694370.0 -155000.0 -0.77 889920.0 -34400.9375 -0.189387479033242 946120.0 -17339.6875 -0.103463937439834 -0.561 -0.6971 2072570 Maybridge1_006088 Cc1cc(C)c(NC(=S)NCCCN2CCOCC2)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M17 compound treatment 710480.0 -160000.0 -0.91 723460.0 -126000.0 -0.63 765190.0 -159130.9375 -0.876063540109084 804800.0 -158659.6875 -0.94670425760116 -1.6823 -0.989 2072571 Maybridge1_006089 Nc1ccccc1NC(=S)Nc2cccc(c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M18 compound treatment 780760.0 -89700.0 -0.51 663960.0 -185000.0 -0.93 750830.0 -173490.9375 -0.955119647196787 734610.0 -228849.6875 -1.36551998129295 -1.8793 -0.9521 1450707 Maybridge1_006090 OCCNC(=S)NC1CCCCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M19 compound treatment 760690.0 -110000.0 -0.63 778290.0 -70700.0 -0.35 850110.0 -74210.9375 -0.408553469504093 837170.0 -126289.6875 -0.753556159924808 -1.0715 -0.9571 2072572 Maybridge1_006091 COc1ccccc1/N=C/2\SCC(=O)N2Cc3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M20 compound treatment 739370.0 -131000.0 -0.75 625440.0 -224000.0 -1.12 758770.0 -165550.9375 -0.911407565701219 824540.0 -138919.6875 -0.828917929268408 -1.8037 -0.9886 2072573 Maybridge1_006092 Oc1cc(nc(SCC(=O)c2ccc(cc2)[N+](=O)[O-])n1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M21 compound treatment 741530.0 -129000.0 -0.74 657990.0 -191000.0 -0.96 751130.0 -173190.9375 -0.953468057215846 775690.0 -187769.6875 -1.1204003071334 -1.8829 -0.9897 1514590 Maybridge1_006093 Fc1ccc(NC(=S)Nc2ccc3cn[nH]c3c2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M22 compound treatment 761530.0 -109000.0 -0.62 644860.0 -204000.0 -1.02 699250.0 -225070.9375 -1.23908301791988 722270.0 -241189.6875 -1.43915135371575 -2.1608 -0.9629 2072574 Maybridge1_006094 Cc1csc(Nc2cccc3ccccc23)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M23 mock treatment 835760.0 -34700.0 -0.2 796770.0 -52200.0 -0.26 831470.0 -92850.9375 -0.511172260319885 787150.0 -176309.6875 -1.05201979433232 -1.0114 -0.8326 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 M24 mock treatment 967140.0 96700.0 0.55 888680.0 39700.0 0.2 840490.0 -83830.9375 -0.46151445489293 886840.0 -76619.6875 -0.457180935594118 -0.084 -0.096 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N01 compound treatment 728970.0 -142000.0 -0.81 724600.0 -124000.0 -0.62 882880.0 -41440.9375 -0.228144790585987 800320.0 -163139.6875 -0.97343590658448 -1.3161 -0.9214 2072575 Maybridge1_006095 CS/C(=N\C)/Nc1cc(C)c(C)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N02 compound treatment 942450.0 72000.0 0.41 774440.0 -74600.0 -0.37 830920.0 -93400.9375 -0.514200175284943 835970.0 -127489.6875 -0.76071642304534 -0.6183 -0.5763 2072576 Maybridge1_006096 COc1ccc(OC)c(Sc2nc(C)c([N+](=O)[O-])c(C)c2C#N)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N03 compound treatment 854780.0 -15700.0 -0.09 642420.0 -207000.0 -1.03 714500.0 -209820.9375 -1.15512719388872 751890.0 -211569.6875 -1.26241219235729 -1.7702 -0.8847 2067914 Maybridge1_006097 C=CCSc1nc2ccccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N04 compound treatment 748340.0 -122000.0 -0.7 682200.0 -167000.0 -0.83 799080.0 -125240.9375 -0.689488925262133 736090.0 -227369.6875 -1.35668899011096 -1.7891 -0.9565 1012507 Maybridge1_006098 CCOC(=O)c1c(C#N)c(O)nc(C)c1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N05 compound treatment 938760.0 68300.0 0.39 808600.0 -40400.0 -0.2 867160.0 -57160.9375 -0.314688105587288 889300.0 -74159.6875 -0.442502396197027 -0.2846 -0.4075 2072577 Maybridge1_006099 NS(=O)(=O)c1ccc(cc1)c2ccc(/C=N/O)o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N06 compound treatment 808610.0 -61900.0 -0.35 720000.0 -129000.0 -0.65 812280.0 -112040.9375 -0.616818966100735 796900.0 -166559.6875 -0.993842656477996 -1.3046 -0.9442 2072578 Maybridge1_006100 Cc1nc(O)c(C#N)c(C)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N07 compound treatment 848400.0 -22100.0 -0.13 720320.0 -129000.0 -0.64 862260.0 -62060.9375 -0.341664075275989 842500.0 -120959.6875 -0.721752657897778 -0.9166 -0.887 2072579 Maybridge1_006101 Nc1ncnc(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N08 compound treatment 764430.0 -106000.0 -0.61 703490.0 -146000.0 -0.73 772100.0 -152220.9375 -0.83802191754808 795710.0 -167749.6875 -1.00094325073919 -1.5863 -0.9836 2072580 Maybridge1_006102 Cc1nc(nc(O)c1Cl)c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N09 compound treatment 767000.0 -103000.0 -0.59 694990.0 -154000.0 -0.77 751460.0 -172860.9375 -0.951651308236811 802720.0 -160739.6875 -0.959115380343416 -1.6361 -0.9833 2072581 Maybridge1_006103 COc1cc(/C=N/OC(=O)c2ccc(Cl)cc2)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N10 compound treatment 585040.0 -285000.0 -1.63 562810.0 -286000.0 -1.43 605920.0 -318400.9375 -1.75289266099058 716320.0 -247139.6875 -1.47465432502172 -3.1447 -0.9967 2072582 Maybridge1_006104 Brc1coc2ccccc2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N11 compound treatment 840510.0 -30000.0 -0.17 686530.0 -162000.0 -0.81 809890.0 -114430.9375 -0.629976632948897 817570.0 -145889.6875 -0.870507124226832 -1.2421 -0.9147 2072583 Maybridge1_006105 OC(=O)COc1ccc(OC(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N12 compound treatment 601280.0 -269000.0 -1.54 455250.0 -394000.0 -1.97 528200.0 -396120.9375 -2.180764572053 567360.0 -396099.6875 -2.36348165371711 -4.0257 -0.9885 2072584 Maybridge1_006106 Cc1onc(c1NC(=O)O/N=C/c2ccc(Cl)cc2Cl)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N13 compound treatment 650250.0 -220000.0 -1.26 669350.0 -180000.0 -0.9 661940.0 -262380.9375 -1.44448575854956 666400.0 -297059.6875 -1.77252127083586 -2.6868 -0.9734 1007516 Maybridge1_006107 Cc1cc(cc(C)c1[N+](=O)[O-])C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N14 compound treatment 533360.0 -337000.0 -1.93 602730.0 -246000.0 -1.23 659220.0 -265100.9375 -1.45946017437676 614010.0 -349449.6875 -2.08512642490642 -3.351 -0.9795 2072585 Maybridge1_006108 Clc1ccc(NC(=O)NNc2c(Cl)cncc2Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N15 compound treatment 759890.0 -111000.0 -0.63 729820.0 -119000.0 -0.6 792080.0 -132240.9375 -0.728026024817419 852130.0 -111329.6875 -0.664291546355508 -1.3101 -0.9973 2072586 Maybridge1_006109 CSc1nc(C)cc(C)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N16 compound treatment 816880.0 -53600.0 -0.31 700920.0 -148000.0 -0.74 831520.0 -92800.9375 -0.510896995323062 897760.0 -65699.6875 -0.392022541197276 -0.9749 -0.9482 2072587 Maybridge1_006110 CCOC(=O)NC(=S)Nc1ccc(cc1NC(=S)NC(=O)OCC)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N17 compound treatment 527430.0 -343000.0 -1.96 545990.0 -303000.0 -1.52 688660.0 -235660.9375 -1.2973841442471 740110.0 -223349.6875 -1.33270210865718 -3.0526 -0.9854 2072588 Maybridge1_006111 FC(F)(F)c1cc(N=NN2CCOCC2)cc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N18 compound treatment 77480.0 -793000.0 -4.53 87620.0 -761000.0 -3.81 155360.0 -768960.9375 -4.23336060036629 99540.0 -863919.6875 -5.15491023125653 -8.8632 -0.9939 1552789 Maybridge1_006112 Cc1nccc(O)c1OCc2ccc(Cl)cc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N19 compound treatment 661920.0 -209000.0 -1.19 782490.0 -66500.0 -0.33 784640.0 -139680.9375 -0.768985456344752 862580.0 -100879.6875 -0.601937588347541 -1.4475 -0.9185 2072589 Maybridge1_006113 CCc1cccc(CC)c1NC(=O)C(Sc2ccccn2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N20 compound treatment 750850.0 -120000.0 -0.68 728640.0 -120000.0 -0.6 775420.0 -148900.9375 -0.819744321759001 789340.0 -174119.6875 -1.03895231413735 -1.572 -0.9786 2072590 Maybridge1_006114 N/C(=N\O)/c1ccc(OCc2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N21 compound treatment 808960.0 -61500.0 -0.35 796360.0 -52600.0 -0.26 790020.0 -134300.9375 -0.739366942686546 803420.0 -160039.6875 -0.954938560189772 -1.1545 -0.8984 2072591 Maybridge1_006115 Sc1nnc([nH]1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N22 compound treatment 712160.0 -158000.0 -0.9 724320.0 -125000.0 -0.62 774310.0 -150010.9375 -0.825855204688483 1002400.0 38940.3125 0.23235240291312 -1.0607 -0.761 2072592 Maybridge1_006116 CS/C(=N\C#N)/NCc1ccccn1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N23 mock treatment 955740.0 85300.0 0.49 907840.0 58800.0 0.29 1078640.0 154319.0625 0.849572724977285 893490.0 -69969.6875 -0.417501144134503 0.6067 0.5493 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 N24 mock treatment 963010.0 92500.0 0.53 908680.0 59700.0 0.3 907520.0 -16800.9375 -0.0924942001513783 900700.0 -62759.6875 -0.374479896551973 0.1801 0.2503 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O01 compound treatment 879360.0 8880.0 0.05 904960.0 56000.0 0.28 961720.0 37399.0625 0.205893056405269 1007240.0 43780.3125 0.261232130832599 0.3989 0.9114 2072593 Maybridge1_006117 Cc1ccc(Nc2nnc(S)s2)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O02 compound treatment 865030.0 -5450.0 -0.03 724580.0 -124000.0 -0.62 843960.0 -80360.9375 -0.442411064113381 830570.0 -132889.6875 -0.792937607087734 -0.9444 -0.8576 2072594 Maybridge1_006118 COCCCNC(=S)Nc1ccc(Oc2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O03 compound treatment 883360.0 12900.0 0.07 741490.0 -108000.0 -0.54 903280.0 -21040.9375 -0.115836671882009 946750.0 -16709.6875 -0.0997047993015547 -0.3398 -0.6027 2072595 Maybridge1_006119 NC(=S)NCc1ccncc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O04 compound treatment 782440.0 -88000.0 -0.5 780110.0 -68900.0 -0.34 881090.0 -43230.9375 -0.237999277472268 916000.0 -47459.6875 -0.283186541765189 -0.6843 -0.9597 1091572 Maybridge1_006120 Cc1cc(=O)n2c(csc2n1)c3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O05 compound treatment 714820.0 -156000.0 -0.89 679680.0 -169000.0 -0.85 904490.0 -19830.9375 -0.109175258958881 775490.0 -187969.6875 -1.12159368432016 -1.4834 -0.8901 1065250 Maybridge1_006121 COc1cccc(NC(=S)N)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O06 compound treatment 835860.0 -34600.0 -0.2 709040.0 -140000.0 -0.7 922630.0 -1690.9375 -0.00930911811132392 745600.0 -217859.6875 -1.29994390488074 -1.1035 -0.7408 2072596 Maybridge1_006122 CSc1nnnn1c2c(C)cccc2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O07 compound treatment 880690.0 10200.0 0.06 698400.0 -151000.0 -0.75 834340.0 -89980.9375 -0.495372049502217 870330.0 -93129.6875 -0.555694222360772 -0.873 -0.8231 2072597 Maybridge1_006123 NNC(=O)c1cncc(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O08 compound treatment 675120.0 -195000.0 -1.12 675870.0 -173000.0 -0.87 711120.0 -213200.9375 -1.17373510767399 857520.0 -105939.6875 -0.632130031172452 -1.8939 -0.9751 2072598 Maybridge1_006124 Cc1cc(NC(=S)N2CCCCC2)ccc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O09 compound treatment 810770.0 -59700.0 -0.34 662610.0 -186000.0 -0.93 742810.0 -181510.9375 -0.999272152687272 988800.0 25340.3125 0.151202754213756 -1.0607 -0.7488 1312083 Maybridge1_006125 COC(=O)c1ccc(NS(=O)(=O)c2ccc(C)cc2)c(NS(=O)(=O)c3ccc(C)cc3)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O10 compound treatment 582940.0 -288000.0 -1.64 412130.0 -437000.0 -2.19 564110.0 -360210.9375 -1.98306925133437 580710.0 -382749.6875 -2.28382372650119 -4.0472 -0.9927 1774250 Maybridge1_006126 [O-][N+](=O)c1ccc(cc1)c2cn3ccccc3n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O11 compound treatment 864870.0 -5610.0 -0.03 685710.0 -163000.0 -0.82 850720.0 -73600.9375 -0.405195236542847 836010.0 -127449.6875 -0.760477747607989 -1.0072 -0.8481 2072599 Maybridge1_006127 CCOC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O12 compound treatment 901170.0 30700.0 0.18 834940.0 -14100.0 -0.07 1002270.0 77949.0625 0.429132968829108 937310.0 -26149.6875 -0.156032202516407 0.1891 0.3826 1252858 Maybridge1_006128 OC(=O)c1ccccc1NC(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O13 compound treatment 786620.0 -83900.0 -0.48 812610.0 -36400.0 -0.18 884320.0 -40000.9375 -0.220217158677471 833040.0 -130419.6875 -0.778199398831306 -0.8297 -0.8666 2072600 Maybridge1_006129 COC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O14 compound treatment 872350.0 1870.0 0.01 845840.0 -3160.0 -0.02 899130.0 -25190.9375 -0.138683666618358 884800.0 -78659.6875 -0.469353382899023 -0.3066 -0.6259 1206269 Maybridge1_006130 CCCCn1c(O)cc(N)nc1=S 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O15 compound treatment 779130.0 -91400.0 -0.52 713760.0 -135000.0 -0.68 808480.0 -115840.9375 -0.637739105859319 844410.0 -119049.6875 -0.710355905764264 -1.2732 -0.9938 2072601 Maybridge1_006131 Cc1nc2ccc(cc2nc1C)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O16 compound treatment 949280.0 78800.0 0.45 740890.0 -108000.0 -0.54 817320.0 -107000.9375 -0.589072254420929 914510.0 -48949.6875 -0.292077201806516 -0.4859 -0.5045 1664455 Maybridge1_006132 COc1ccccc1C(=O)OCC(=O)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O17 compound treatment 666490.0 -204000.0 -1.17 653710.0 -195000.0 -0.98 776180.0 -148140.9375 -0.815560293807285 933920.0 -29539.6875 -0.17625994583191 -1.5669 -0.9034 1522957 Maybridge1_006133 Cc1cc(C)c(Nc2nnns2)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O18 compound treatment 777990.0 -92500.0 -0.53 711920.0 -137000.0 -0.69 773970.0 -150350.9375 -0.827727006666882 1060100.0 96640.3125 0.576641721292037 -0.7325 -0.5511 2072602 Maybridge1_006134 COc1ccccc1NC(=N)SCc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O19 compound treatment 693150.0 -177000.0 -1.01 842240.0 -6760.0 -0.03 939530.0 15209.0625 0.0837304508150109 847860.0 -115599.6875 -0.689770149292735 -0.8264 -0.6725 2072603 Maybridge1_006135 Cc1csc(Nc2ccc(Cl)cc2)[n+]1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O20 compound treatment 796640.0 -73800.0 -0.42 785760.0 -63200.0 -0.32 913280.0 -11040.9375 -0.0607836725173139 946880.0 -16579.6875 -0.0989291041301637 -0.4489 -0.8315 1133744 Maybridge1_006136 COc1ccc(CCNC(=S)Nc2c(C)cccc2C)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O21 compound treatment 741530.0 -129000.0 -0.74 756900.0 -92100.0 -0.46 993200.0 68879.0625 0.37919989840533 1048220.0 84760.3125 0.505755116398769 -0.1561 -0.1453 2072604 Maybridge1_006137 Fc1ccccc1/N=C/2\SCC(=O)N2c3ccccc3F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O22 compound treatment 846630.0 -23900.0 -0.14 735050.0 -114000.0 -0.57 827920.0 -96400.9375 -0.530716075094352 1089250.0 125790.3125 0.750576446261628 -0.2431 -0.223 2072605 Maybridge1_006138 CC(C)(C)c1ccc(OC(=O)c2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O23 mock treatment 862020.0 -8460.0 -0.05 954340.0 105000.0 0.53 1091410.0 167089.0625 0.919875405166001 1071950.0 108490.3125 0.647349319607291 1.0229 0.8229 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 O24 mock treatment 978440.0 108000.0 0.62 970400.0 121000.0 0.61 978420.0 54099.0625 0.29783156534431 1078130.0 114670.3125 0.684224674678031 1.103 0.9652 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P01 compound treatment 889690.0 19200.0 0.11 834240.0 -14800.0 -0.07 893800.0 -30520.9375 -0.16802691527974 940070.0 -23389.6875 -0.139563597339183 -0.1358 -0.532 2072606 Maybridge1_006139 COc1ccccc1N/C(=N/C)/SC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P02 compound treatment 941980.0 71500.0 0.41 888180.0 39200.0 0.2 1020960.0 96639.0625 0.532027024641724 1008800.0 45340.3125 0.270540472889291 0.7035 0.9388 2072607 Maybridge1_006140 Cc1nc(Sc2ccc(Br)cc2)c(C#N)c(C)c1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P03 compound treatment 787040.0 -83400.0 -0.48 690440.0 -159000.0 -0.79 801380.0 -122940.9375 -0.676826735408253 844760.0 -118699.6875 -0.708267495687443 -1.3274 -0.9851 2072608 Maybridge1_006141 CCOC(=O)CSC(=S)Nc1c(C)cc(C)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P04 compound treatment 711070.0 -159000.0 -0.91 580990.0 -268000.0 -1.34 647130.0 -277190.9375 -1.52601925060868 755050.0 -208409.6875 -1.24355683280655 -2.5103 -0.9845 2072609 Maybridge1_006142 Cc1onc(c1C#N)c2c(F)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P05 compound treatment 800030.0 -70500.0 -0.4 732240.0 -117000.0 -0.58 749480.0 -174840.9375 -0.962551802111021 856740.0 -106719.6875 -0.636784202200797 -1.2929 -0.9544 2072610 Maybridge1_006143 FC(F)(F)c1nnc(Nc2ccc(Cl)cc2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P06 compound treatment 896880.0 26400.0 0.15 668000.0 -181000.0 -0.91 830410.0 -93910.9375 -0.517007878252543 821080.0 -142379.6875 -0.849563354599275 -1.0605 -0.7837 2072611 Maybridge1_006144 CCOC(=O)c1cc(C)nc(SC)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P07 compound treatment 973040.0 103000.0 0.59 741380.0 -108000.0 -0.54 862900.0 -61420.9375 -0.338140683316648 917090.0 -46369.6875 -0.276682636097372 -0.2836 -0.3125 1729679 Maybridge1_006145 Nc1ncnc(Nc2ccccc2F)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P08 compound treatment 928000.0 57500.0 0.33 784500.0 -64500.0 -0.32 793810.0 -130510.9375 -0.718501855927327 801440.0 -162019.6875 -0.96675299433865 -0.8396 -0.6511 2072612 Maybridge1_006146 Cc1cc(O)nc(n1)c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P09 compound treatment 963130.0 92600.0 0.53 819920.0 -29100.0 -0.15 968160.0 43839.0625 0.241347187996133 1108640.0 145180.3125 0.866274364517559 0.7457 0.7078 2072613 Maybridge1_006147 COc1cc(/C=N/OC(=O)c2ccc(Cl)c(Cl)c2)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P10 compound treatment 725760.0 -145000.0 -0.83 671060.0 -178000.0 -0.89 868280.0 -56040.9375 -0.308522169658442 814980.0 -148479.6875 -0.885961358795313 -1.4556 -0.9484 1170374 Maybridge1_006148 O=c1c(C#N)coc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P11 compound treatment 902370.0 31900.0 0.18 837770.0 -11200.0 -0.06 1042520.0 118199.0625 0.650721291272006 909360.0 -54099.6875 -0.322806664365466 0.227 0.3022 2072614 Maybridge1_006149 CC(Oc1ccc(OC(F)(F)F)cc1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P12 compound treatment 978770.0 108000.0 0.62 837940.0 -11100.0 -0.06 1021290.0 96969.0625 0.533843773620759 857170.0 -106289.6875 -0.634218441249273 0.2315 0.2235 2072615 Maybridge1_006150 Cc1onc(c1NC(=O)O/N=C/c2cccc(c2)[N+](=O)[O-])c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P13 compound treatment 934050.0 63600.0 0.36 915800.0 66800.0 0.33 1093040.0 168719.0625 0.928849044062446 1025330.0 61870.3125 0.36917309737462 0.9976 0.895 2072616 Maybridge1_006151 COCCCNC(=O)c1cccs1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P14 compound treatment 995160.0 125000.0 0.71 886670.0 37700.0 0.19 896270.0 -28050.9375 -0.15442882443666 840240.0 -123219.6875 -0.735237820108113 0.0055 0.0052 2072617 Maybridge1_006152 C/C(=N\OC(=O)Nc1c(C)onc1c2c(Cl)cccc2Cl)/c3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P15 compound treatment 809700.0 -60800.0 -0.35 859360.0 10400.0 0.05 943410.0 19089.0625 0.105091014568513 965080.0 1620.3125 0.00966821986457259 -0.0903 -0.2463 2072618 Maybridge1_006153 Cc1cc(C)c(C#N)c(S)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P16 compound treatment 817920.0 -52600.0 -0.3 921600.0 72600.0 0.36 1072010.0 147689.0625 0.813072586398492 902570.0 -60889.6875 -0.36332181985581 0.2563 0.2544 2072619 Maybridge1_006154 CC(=NOC(=O)Nc1ccc(cc1)C(F)(F)F)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P17 compound treatment 724020.0 -146000.0 -0.84 808850.0 -40100.0 -0.2 1044550.0 120229.0625 0.661897050143039 1067650.0 104190.3125 0.621691710092051 0.1231 0.0984 2072620 Maybridge1_006155 Oc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P18 compound treatment 972260.0 102000.0 0.58 955680.0 107000.0 0.53 1069140.0 144819.0625 0.797272375580825 1082670.0 119210.3125 0.711314336817377 1.3118 0.9876 2072621 Maybridge1_006156 Cc1onc(c1NC(=O)O/N=C(\N)/Cc2ccc(cc2)C(C)(C)C)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P19 compound treatment 952650.0 82200.0 0.47 894020.0 45000.0 0.23 984570.0 60249.0625 0.331689159953598 889840.0 -73619.6875 -0.439280277792788 0.2935 0.3874 1493707 Maybridge1_006157 COc1ccc(CCNC(=O)C(Sc2ccccc2N)c3ccccc3)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P20 compound treatment 749670.0 -121000.0 -0.69 831280.0 -17700.0 -0.09 961530.0 37209.0625 0.20484704941734 907850.0 -55609.6875 -0.331816662125469 -0.4529 -0.5678 2072622 Maybridge1_006158 N/C(=N\OC(=O)C(Cl)Cl)/c1ccc(OCc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P21 compound treatment 869410.0 -1070.0 -0.01 719650.0 -129000.0 -0.65 955730.0 31409.0625 0.172916309785817 935370.0 -28089.6875 -0.167607961227934 -0.3239 -0.4692 2072623 Maybridge1_006159 Sc1nnc([nH]1)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P22 compound treatment 882720.0 12200.0 0.07 860440.0 11400.0 0.06 949400.0 25079.0625 0.138067761187965 958400.0 -5059.6875 -0.0301905781730559 0.1175 0.7006 2072624 Maybridge1_006160 Clc1ccc(/N=C/2\SCC(=O)N2C(=O)c3ccccc3Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P23 mock treatment 936830.0 66300.0 0.38 950470.0 101000.0 0.51 1009630.0 85309.0625 0.469651976361524 1029410.0 65950.3125 0.393517991984429 0.8749 0.9927 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.558 P24 mock treatment 892720.0 22200.0 0.13 921880.0 72900.0 0.36 961480.0 37159.0625 0.204571784420517 986850.0 23390.3125 0.139567326642892 0.4179 0.9111 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A01 compound treatment 912190.0 13200.0 0.08 921510.0 -21800.0 -0.11 890720.0 -14684.333333333 -0.0808416593670955 874240.0 15065.806451613 0.089895948597132 -0.0123 -0.0686 2072625 Maybridge1_006161 Fc1cccc(F)c1C(=O)NC(=S)Nc2cccc(c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A02 compound treatment 1021320.0 122000.0 0.7 1000700.0 57400.0 0.29 937710.0 32305.666666667 0.177852384647607 935760.0 76585.806451613 0.456978771243076 0.8103 0.8998 2072626 Maybridge1_006162 COC(=O)c1ccc(OCC(F)(F)F)nc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A03 compound treatment 981190.0 82200.0 0.47 939130.0 -4130.0 -0.02 924200.0 18795.666666667 0.103475782505904 929550.0 70375.806451613 0.419924409594322 0.486 0.7612 1461450 Maybridge1_006163 COC(=O)c1cc(=O)nc(N)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A04 compound treatment 1010460.0 111000.0 0.64 995960.0 52700.0 0.26 998990.0 93585.666666667 0.515217164754459 931740.0 72565.806451613 0.432991889789293 0.9242 0.9596 2072627 Maybridge1_006164 CC1(C)ONC(=O)N(CCc2cccs2)C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A05 compound treatment 910280.0 11200.0 0.06 874650.0 -68600.0 -0.34 891650.0 -13754.333333333 -0.0757217304261788 874720.0 15545.806451613 0.0927600538453448 -0.1309 -0.3548 2072628 Maybridge1_006165 N/C(=N\OC(=O)Nc1ccccc1)/c2ccc(cc2)C3SCCS3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A06 compound treatment 1006350.0 107000.0 0.61 892500.0 -50800.0 -0.25 959520.0 54115.666666667 0.297922976262007 966460.0 107285.806451613 0.640162169410021 0.6486 0.6694 2072629 Maybridge1_006166 FC(F)(F)c1cccc(c1)C(=O)NNC(=O)C2c3ccccc3Oc4ccccc24 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A07 compound treatment 1006950.0 108000.0 0.62 1054970.0 112000.0 0.56 973600.0 68195.666666667 0.375437599367498 986410.0 127235.806451613 0.759201543788867 1.1549 0.9728 1378127 Maybridge1_006167 COc1nc(N)nc(n1)C(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A08 compound treatment 1021250.0 122000.0 0.7 1026720.0 83500.0 0.42 1028580.0 123175.666666667 0.678118989874592 982560.0 123385.806451613 0.736229032943826 1.265 0.9808 1110159 Maybridge1_006168 CC(=O)Nc1ccc(NC(=O)C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A09 compound treatment 1002560.0 104000.0 0.59 989850.0 46600.0 0.23 989380.0 83975.666666667 0.462311232364987 956220.0 97045.806451613 0.579061257448148 0.9329 0.9556 2072630 Maybridge1_006169 CSc1nc(N)nc(n1)c2cccnc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A10 compound treatment 999920.0 101000.0 0.58 933560.0 -9700.0 -0.05 1000370.0 94965.666666667 0.522814478666787 957310.0 98135.806451613 0.585565163115964 0.8181 0.839 2072631 Maybridge1_006170 CCOC(=O)c1cnn(c1N)c2ccc(F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A11 compound treatment 1048290.0 149000.0 0.85 941780.0 -1480.0 -0.01 992800.0 87395.666666667 0.481139358147713 967390.0 108215.806451613 0.645711373328434 0.986 0.8407 1652130 Maybridge1_006171 Cn1c(nc(N)nc1=O)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A12 compound treatment 1025970.0 127000.0 0.73 1009440.0 66200.0 0.33 918770.0 13365.666666667 0.0735820038508744 1016040.0 156865.806451613 0.936000374006671 1.0328 0.8386 2072632 Maybridge1_006172 CN(C)/C=N\c1ccc2nnc(c3ccccc3)n2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A13 compound treatment 1023740.0 125000.0 0.71 1009230.0 66000.0 0.33 944570.0 39165.666666667 0.215618742211788 935780.0 76605.806451613 0.457098108961751 0.8575 0.9184 2072633 Maybridge1_006173 O=C1CNC(=S)N1CCCn2ccnc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A14 compound treatment 1111470.0 212000.0 1.21 1155390.0 212000.0 1.06 1111410.0 206005.666666667 1.13412298361236 1033850.0 174675.806451613 1.04227061248723 2.2255 0.9982 1083204 Maybridge1_006174 Cc1ccc2ncnc(O)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A15 compound treatment 993730.0 94700.0 0.54 948010.0 4750.0 0.02 918480.0 13075.666666667 0.0719854668692983 858190.0 -984.193548387033 -0.00587257063998439 0.3154 0.5774 2072634 Maybridge1_006175 Clc1ccc(CN2C(=O)CNC2=S)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A16 compound treatment 1041870.0 143000.0 0.82 983620.0 40400.0 0.2 1037930.0 132525.666666667 0.729593544280582 963790.0 104615.806451613 0.624230583966837 1.1858 0.9292 2072635 Maybridge1_006176 [O-][N+](=O)c1cccnc1NC2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A17 compound treatment 1041940.0 143000.0 0.82 1064640.0 121000.0 0.61 999680.0 94275.666666667 0.519015821710623 980920.0 121745.806451613 0.726443340012433 1.3344 0.9859 1052429 Maybridge1_006177 COc1nc(N)nc(OC)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A18 compound treatment 1117520.0 218000.0 1.25 955130.0 11900.0 0.06 914190.0 8785.66666666698 0.0483677301418441 961400.0 102225.806451613 0.609969726585111 0.9829 0.7065 2072636 Maybridge1_006178 FC(F)(F)c1cc(cc(c1)S(=O)(=O)NNC(=O)CSc2nc3cccnc3s2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A19 compound treatment 998690.0 99700.0 0.57 1079740.0 136000.0 0.68 1000130.0 94725.666666667 0.521493206682034 998640.0 139465.806451613 0.832176558758956 1.3028 0.9835 2072637 Maybridge1_006179 NC(=O)c1cnccc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A20 compound treatment 773320.0 -126000.0 -0.72 772740.0 -171000.0 -0.85 750200.0 -155204.333333333 -0.854446406439792 717630.0 -141544.193548387 -0.84457805749164 -1.635 -0.9975 1546171 Maybridge1_006180 Clc1ccc2c(Sc3nnc(NC(=O)c4cccnc4Oc5ccccc5)s3)ccnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A21 compound treatment 1048860.0 150000.0 0.86 998480.0 55200.0 0.28 1002470.0 97065.666666667 0.534375608533373 942240.0 83065.806451613 0.495644192093949 1.081 0.9339 2072638 Maybridge1_006181 COc1cc(c(cn1)C(=O)N)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A22 compound treatment 1013350.0 114000.0 0.65 907560.0 -35700.0 -0.18 989820.0 84415.666666667 0.464733564337034 929230.0 70055.806451613 0.418015006095514 0.6786 0.7365 1012003 Maybridge1_006182 COC(=O)c1cc(ccc1NC(=O)C)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A23 mock treatment 1080390.0 181000.0 1.04 960880.0 17600.0 0.09 995390.0 89985.666666667 0.495398084983169 996800.0 137625.806451613 0.821197488640807 1.2204 0.8627 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 A24 mock treatment 844160.0 -54900.0 -0.31 904830.0 -38400.0 -0.19 938510.0 33105.666666667 0.182256624596783 915380.0 56205.806451613 0.335373635912706 0.006 0.0113 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B01 compound treatment 1095000.0 196000.0 1.12 991130.0 47900.0 0.24 987630.0 82225.666666667 0.452676957476165 1019900.0 160725.806451613 0.959032553711049 1.3853 0.8877 1304551 Maybridge1_006183 CCCCc1ccc(NC(=O)CSc2nc(c(o2)c3ccccc3)c4ccccc4)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B02 compound treatment 869710.0 -29300.0 -0.17 920110.0 -23200.0 -0.12 948000.0 42595.666666667 0.234501920993878 826270.0 -32904.193548387 -0.196335569646137 -0.1226 -0.3336 2072639 Maybridge1_006184 CCOC(=O)CNC(=O)CC(=O)OCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B03 compound treatment 920510.0 21500.0 0.12 897600.0 -45700.0 -0.23 904990.0 -414.333333333023 -0.00228102927367549 916020.0 56845.806451613 0.339192442910323 0.1156 0.2708 2072640 Maybridge1_006185 CC(NCc1ccc(OCc2ccc(F)cc2)cc1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B04 compound treatment 864250.0 -34800.0 -0.2 855070.0 -88200.0 -0.44 793070.0 -112334.333333333 -0.618434198163344 832800.0 -26374.193548387 -0.157371804498575 -0.7078 -0.8839 2072641 Maybridge1_006186 COc1ccc(cc1)/C(=N/O)/N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B05 compound treatment 871850.0 -27200.0 -0.16 881280.0 -62000.0 -0.31 874720.0 -30684.333333333 -0.168926458350608 827360.0 -31814.193548387 -0.189831663978321 -0.412 -0.9585 1600962 Maybridge1_006187 COc1ccc(cc1)N(Cc2ccccc2)Cc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B06 compound treatment 898270.0 -763.0 0.0 854340.0 -88900.0 -0.44 831570.0 -73834.333333333 -0.406480150609267 825080.0 -34094.193548387 -0.203436163907332 -0.5295 -0.8326 2072642 Maybridge1_006188 COc1cc(N2CCCC2)c(cc1[N+](=O)[O-])[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B07 compound treatment 932320.0 33300.0 0.19 898910.0 -44400.0 -0.22 834960.0 -70444.333333333 -0.387817183824636 861890.0 2715.80645161297 0.0162049073149895 -0.2016 -0.4151 1280583 Maybridge1_006189 Oc1c(c2ccccc2)c(=O)n3CCc4cccc1c43 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B08 compound treatment 757250.0 -142000.0 -0.81 788560.0 -155000.0 -0.77 725320.0 -180084.333333333 -0.991418268859153 734720.0 -124454.193548387 -0.742603976883396 -1.6589 -0.9933 2072643 Maybridge1_006190 CCOC(=O)c1cc2cc(F)ccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B09 compound treatment 860680.0 -38400.0 -0.22 815580.0 -128000.0 -0.64 817920.0 -87484.333333333 -0.481627494742076 779320.0 -79854.193548387 -0.476480864236954 -0.9079 -0.9492 2072644 Maybridge1_006191 COc1ccc(c(OC)c1)S(=O)(=O)Nc2cc(C)c(C)cc2[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B10 compound treatment 885790.0 -13200.0 -0.08 821510.0 -122000.0 -0.61 793220.0 -112184.333333333 -0.617608403172873 840440.0 -18734.193548387 -0.111784795964521 -0.707 -0.8054 1648563 Maybridge1_006192 O=C(NC1CCN(Cc2ccccc2)CC1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B11 compound treatment 797820.0 -101000.0 -0.58 798400.0 -145000.0 -0.72 687400.0 -218004.333333333 -1.20017924245008 756530.0 -102644.193548387 -0.612466194667726 -1.5577 -0.9524 2072645 Maybridge1_006193 CCCCCOc1ccc(cc1)C(=O)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B12 compound treatment 941920.0 42900.0 0.24 951970.0 8710.0 0.04 1071360.0 165955.666666667 0.913635721156758 956640.0 97465.806451613 0.581567349540334 0.8919 0.8026 2072646 Maybridge1_006194 CCCCCCCCCCCCCCCCCCN1CNC(=S)NC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B13 compound treatment 1008240.0 109000.0 0.62 987970.0 44700.0 0.22 760840.0 -144564.333333333 -0.795870015115756 873190.0 14015.806451613 0.0836307183666664 0.0676 0.0651 1044813 Maybridge1_006195 Brc1ccc2[nH]ccc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B14 compound treatment 897250.0 -1780.0 -0.01 826090.0 -117000.0 -0.59 764230.0 -141174.333333333 -0.777207048331125 806110.0 -53064.193548387 -0.316627990071076 -0.845 -0.8255 2072647 Maybridge1_006196 Nc1nc(cs1)c2ccc(Cl)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B15 compound treatment 1083640.0 185000.0 1.05 862950.0 -80300.0 -0.4 830930.0 -74474.333333333 -0.410003542568608 878340.0 19165.806451613 0.114360180925617 0.1786 0.1481 1089306 Maybridge1_006197 COC(=O)CNCC(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B16 compound treatment 918650.0 19600.0 0.11 921400.0 -21900.0 -0.11 809520.0 -95884.333333333 -0.52787201420842 904110.0 44935.806451613 0.268126831439043 -0.1285 -0.2098 1008328 Maybridge1_006198 CC(=O)Nc1ccc(OC(=O)C)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B17 compound treatment 764700.0 -134000.0 -0.77 833880.0 -109000.0 -0.55 780740.0 -124664.333333333 -0.686314546380013 742790.0 -116384.193548387 -0.694451207397818 -1.3476 -0.9931 1371751 Maybridge1_006199 Cc1cc(Nc2ccccc2C(=O)O)n(n1)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B18 compound treatment 886570.0 -12500.0 -0.07 805480.0 -138000.0 -0.69 785780.0 -119624.333333333 -0.658567834700207 742320.0 -116854.193548387 -0.697255643786693 -1.0581 -0.8943 1238043 Maybridge1_006200 Fc1cccc(Cl)c1C(=O)Nc2cccc(c2)C(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B19 compound treatment 968740.0 69700.0 0.4 802440.0 -141000.0 -0.7 944420.0 39015.666666667 0.214792947221318 830560.0 -28614.193548387 -0.170737628990235 -0.131 -0.1534 1685353 Maybridge1_006201 COC(=O)c1[nH]c2ccccc2c1C(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B20 compound treatment 34350.0 -865000.0 -4.94 36040.0 -907000.0 -4.54 31420.0 -873984.333333333 -4.81154589477535 36180.0 -822994.193548387 -4.91071247706379 -9.5996 -0.9995 2072648 Maybridge1_006202 Cc1cc(Sc2nnc(n2C)C(F)(F)F)c(cc1[N+](=O)[O-])[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B21 compound treatment 684010.0 -215000.0 -1.23 607550.0 -336000.0 -1.68 543360.0 -362044.333333333 -1.99316264529915 616160.0 -243014.193548387 -1.45003797319196 -3.1753 -0.9845 2072649 Maybridge1_006203 COc1ccc(Oc2ccc(cc2N)C(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B22 compound treatment 1039290.0 140000.0 0.8 850850.0 -92400.0 -0.46 891080.0 -14324.333333333 -0.0788597513899665 890790.0 31615.806451613 0.188647910801137 0.2244 0.2369 2072650 Maybridge1_006204 CCCCCCNC(=O)NCCCCCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B23 mock treatment 1093930.0 195000.0 1.11 1017250.0 74000.0 0.37 932380.0 26975.666666667 0.148509135986225 1010280.0 151105.806451613 0.901631111028117 1.2668 0.8518 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 B24 mock treatment 1010240.0 111000.0 0.64 992430.0 49200.0 0.25 1023680.0 118275.666666667 0.651143020185891 1003530.0 144355.806451613 0.861354630975124 1.1968 0.9374 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C01 compound treatment 868000.0 -31000.0 -0.18 826500.0 -117000.0 -0.58 770800.0 -134604.333333333 -0.74103722774852 745300.0 -113874.193548387 -0.679474323704038 -1.0909 -0.9275 2072651 Maybridge1_006205 COC(=O)c1onc(c1C(=O)OC)c2c(Cl)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C02 compound treatment 809150.0 -89900.0 -0.51 742810.0 -200000.0 -1.0 683490.0 -221914.333333333 -1.22170496520167 737250.0 -121924.193548387 -0.727507755470941 -1.7326 -0.9551 2072652 Maybridge1_006206 COC(=O)c1cc(OCC(F)(F)F)nc(OCC(F)(F)F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C03 compound treatment 809760.0 -89300.0 -0.51 711380.0 -232000.0 -1.16 676000.0 -229404.333333333 -1.26293966172583 747210.0 -111964.193548387 -0.668077571570525 -1.8004 -0.9428 1728994 Maybridge1_006207 CCOC(=O)c1sc(N)nc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C04 compound treatment 819810.0 -79200.0 -0.45 782970.0 -160000.0 -0.8 716000.0 -189404.333333333 -1.04272766426705 754930.0 -104244.193548387 -0.622013212161769 -1.4595 -0.9579 2072653 Maybridge1_006208 O=C1CS/C(=N/N=C/c2ccn[nH]2)/N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C05 compound treatment 667290.0 -232000.0 -1.32 589160.0 -354000.0 -1.77 567460.0 -337944.333333333 -1.86048491683023 595520.0 -263654.193548387 -1.57319449886512 -3.2643 -0.9921 2072654 Maybridge1_006209 N/C(=N\OC(=O)Nc1ccc(Cl)cc1)/c2ccc(cc2)C3SCCS3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C06 compound treatment 831910.0 -67100.0 -0.38 763410.0 -180000.0 -0.9 810760.0 -94644.333333333 -0.521045442287198 788400.0 -70774.193548387 -0.422301539958262 -1.1132 -0.9388 2072655 Maybridge1_006210 [O-][N+](=O)c1cccc(c1)C(=O)NNC(=O)C2c3ccccc3Oc4ccccc24 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C07 compound treatment 950880.0 51800.0 0.3 758890.0 -184000.0 -0.92 717410.0 -187994.333333333 -1.03496519135663 824960.0 -34214.193548387 -0.204152190219385 -0.9325 -0.6512 2072656 Maybridge1_006211 CSc1nc(C)nc(N)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C08 compound treatment 781520.0 -118000.0 -0.67 766560.0 -177000.0 -0.88 728220.0 -177184.333333333 -0.975452899043392 762830.0 -96344.193548387 -0.574874813284933 -1.5527 -0.9793 2072657 Maybridge1_006212 Nc1c(C#N)cnn1c2ccc(F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C09 compound treatment 783680.0 -115000.0 -0.66 773660.0 -170000.0 -0.85 742580.0 -162824.333333333 -0.89639679195569 744810.0 -114364.193548387 -0.682398097811589 -1.543 -0.9913 1409063 Maybridge1_006213 CSc1nc(N)nc(n1)c2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C10 compound treatment 852770.0 -46300.0 -0.26 793530.0 -150000.0 -0.75 736430.0 -168974.333333333 -0.930254386564977 953170.0 93995.806451613 0.560862255350129 -0.6913 -0.5137 1005947 Maybridge1_006214 OC(=O)CCC(=O)c1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C11 compound treatment 635160.0 -264000.0 -1.51 559750.0 -384000.0 -1.92 535240.0 -370164.333333333 -2.03786568078328 582630.0 -276544.193548387 -1.6501076585515 -3.5568 -0.9931 2072658 Maybridge1_006215 Cc1onc(c1C(=O)O/N=C(\N)/c2ccc(o2)[N+](=O)[O-])c3cccc(Cl)c3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C12 compound treatment 862940.0 -36100.0 -0.21 762880.0 -180000.0 -0.9 724000.0 -181404.333333333 -0.998685264775293 755220.0 -103954.193548387 -0.620282815240973 -1.3637 -0.9114 2072659 Maybridge1_006216 Sc1nc2cc(Cl)ccc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C13 compound treatment 763740.0 -135000.0 -0.77 848350.0 -94900.0 -0.47 777440.0 -127964.333333333 -0.704482036170362 814260.0 -44914.193548387 -0.267997869710796 -1.11 -0.9412 2072660 Maybridge1_006217 CC(C)(C)C(=O)OCc1nc(cs1)c2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C14 compound treatment 652200.0 -247000.0 -1.41 703560.0 -240000.0 -1.2 618790.0 -286614.333333333 -1.57789787109125 720260.0 -138914.193548387 -0.828885147485808 -2.5078 -0.976 2072661 Maybridge1_006218 COC(=O)C(C)(C)Oc1ccc(C)c2CCCc21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C15 compound treatment 761570.0 -137000.0 -0.79 759460.0 -184000.0 -0.92 684010.0 -221394.333333333 -1.21884220923471 720360.0 -138814.193548387 -0.82828845889243 -1.8758 -0.9841 1222937 Maybridge1_006219 COc1ccc(CN2C(=O)CNC2=S)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C16 compound treatment 785280.0 -114000.0 -0.65 803430.0 -140000.0 -0.7 785600.0 -119804.333333333 -0.659558788688771 777920.0 -81254.193548387 -0.484834504544242 -1.2468 -0.9914 2072662 Maybridge1_006220 CS(=O)(=O)OCCN1CCN(CC1)S(=O)(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C17 compound treatment 731070.0 -168000.0 -0.96 693700.0 -250000.0 -1.25 671530.0 -233874.333333333 -1.28754835244185 684510.0 -174664.193548387 -1.04220131961833 -2.2687 -0.9927 2072663 Maybridge1_006221 CSC1=N/C(=C\N(C)C)/C(=O)N1CCOc2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C18 compound treatment 842110.0 -56900.0 -0.33 770430.0 -173000.0 -0.86 748320.0 -157084.333333333 -0.864796370320355 763010.0 -96164.193548387 -0.573800773816853 -1.3141 -0.9459 2072664 Maybridge1_006222 COC(=O)C(C(=O)OC)c1ccc(Cl)cc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C19 compound treatment 799360.0 -99700.0 -0.57 775170.0 -168000.0 -0.84 771760.0 -133644.333333333 -0.735752139809509 745680.0 -113494.193548387 -0.677206907049203 -1.4115 -0.9905 2072665 Maybridge1_006223 OC1c2ccnn2[C@@H](O)c3ccnn13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C20 compound treatment 765720.0 -133000.0 -0.76 749480.0 -194000.0 -0.97 706770.0 -198634.333333333 -1.09354158268066 756610.0 -102564.193548387 -0.611988843793024 -1.7181 -0.9775 1038600 Maybridge1_006224 [O-][N+](=O)c1ccc2NCCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C21 compound treatment 826090.0 -72900.0 -0.42 765150.0 -178000.0 -0.89 734370.0 -171034.333333333 -0.941595304434104 729280.0 -129894.193548387 -0.775063836363141 -1.5121 -0.9651 2072666 Maybridge1_006225 CC(C)(C)C(=O)OC/C(=N/OC(=O)c1cccs1)/N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C22 compound treatment 856160.0 -42900.0 -0.24 785360.0 -158000.0 -0.79 743680.0 -161724.333333333 -0.890340962025573 713240.0 -145934.193548387 -0.87077268674092 -1.3979 -0.9351 1918351 Maybridge1_006226 Oc1ccc2ccccc2c1C(/N=C/c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C23 mock treatment 908160.0 9130.0 0.05 873760.0 -69500.0 -0.35 789350.0 -116054.333333333 -0.63891391392701 803850.0 -55324.193548387 -0.330113152281411 -0.6323 -0.7899 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 C24 mock treatment 880040.0 -19000.0 -0.11 799860.0 -143000.0 -0.72 714030.0 -191374.333333333 -1.05357310514189 795220.0 -63954.193548387 -0.381607377889905 -1.1305 -0.8469 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D01 compound treatment 784600.0 -114000.0 -0.65 824590.0 -119000.0 -0.59 772890.0 -132514.333333333 -0.729531150881299 866690.0 7515.80645161297 0.0448459597971177 -0.966 -0.8427 2072667 Maybridge1_006227 COC(=O)c1ccccc1CSc2ccccc2C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D02 compound treatment 792340.0 -107000.0 -0.61 788640.0 -155000.0 -0.77 779620.0 -125784.333333333 -0.692480482308859 843100.0 -16074.193548387 -0.0959128793806751 -1.0856 -0.899 2072668 Maybridge1_006228 NC(=O)CSc1ccc(cn1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D03 compound treatment 769800.0 -129000.0 -0.74 749780.0 -193000.0 -0.97 701880.0 -203524.333333333 -1.12046249937 712770.0 -146404.193548387 -0.873577123129795 -1.85 -0.9889 1381669 Maybridge1_006229 CCOC(=O)COc1ccc(C)c2CCCc21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D04 compound treatment 706140.0 -193000.0 -1.1 733460.0 -210000.0 -1.05 670920.0 -234484.333333333 -1.2909065854031 672440.0 -186734.193548387 -1.11422163283901 -2.2782 -0.9968 2072669 Maybridge1_006230 c1sc(nc1c2ccccc2)c3cccnc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D05 compound treatment 783090.0 -116000.0 -0.66 709980.0 -233000.0 -1.17 687400.0 -218004.333333333 -1.20017924245008 758340.0 -100834.193548387 -0.60166613112759 -1.8155 -0.9565 2072670 Maybridge1_006231 Fc1ccc(OCc2ccccc2)c(c1)C(=O)CCc3ccc(cc3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D06 compound treatment 799530.0 -99500.0 -0.57 868380.0 -74900.0 -0.37 759790.0 -145614.333333333 -0.801650580049049 778240.0 -80934.193548387 -0.482925101045433 -1.1138 -0.9624 2072671 Maybridge1_006232 CCOC(=O)C(Cc1ccc(F)cc1)(NC(=O)C)C(=O)OCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D07 compound treatment 732480.0 -167000.0 -0.95 745380.0 -198000.0 -0.99 867930.0 -37474.333333333 -0.206307444919236 757220.0 -101954.193548387 -0.60834904337342 -1.3779 -0.9091 2072672 Maybridge1_006233 C(Cc1ccccc1)/N=C/c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D08 compound treatment 802090.0 -96900.0 -0.55 797370.0 -146000.0 -0.73 749060.0 -156344.333333333 -0.860722448367367 755570.0 -103604.193548387 -0.618194405164151 -1.3812 -0.986 2072673 Maybridge1_006234 CCCCCC(=O)Nc1nc-2c(CCc3cc(OC)ccc23)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D09 compound treatment 558190.0 -341000.0 -1.95 530400.0 -413000.0 -2.06 471110.0 -434294.333333333 -2.39092056570907 575560.0 -283614.193548387 -1.6922935421033 -4.0476 -0.9924 1250582 Maybridge1_006235 Cc1ccc(COc2c(c3ccccc3)c(=O)n4CCCc5cc(C)cc2c54)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D10 compound treatment 767880.0 -131000.0 -0.75 695070.0 -248000.0 -1.24 669440.0 -235964.333333333 -1.29905442930907 696680.0 -162494.193548387 -0.969584317804263 -2.1296 -0.9792 2072674 Maybridge1_006236 COc1ccc2-c3nc(N/C=N/O)sc3CCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D11 compound treatment 612680.0 -286000.0 -1.64 622650.0 -321000.0 -1.6 533070.0 -372334.333333333 -2.04981218164542 509980.0 -349194.193548387 -2.08360192164038 -3.6864 -0.9927 1077542 Maybridge1_006237 C1Cc2ccccc2-c3[nH]c4ccccc4c13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D12 compound treatment 698370.0 -201000.0 -1.15 586690.0 -357000.0 -1.78 596730.0 -308674.333333333 -1.69934478768977 630400.0 -228774.193548387 -1.36506951749498 -2.9971 -0.9857 1021563 Maybridge1_006238 CCc1c(C)[nH]c2ccc(cc12)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D13 compound treatment 816270.0 -82800.0 -0.47 931840.0 -11400.0 -0.06 857970.0 -47434.333333333 -0.261140232286472 806470.0 -52704.193548387 -0.314479911134916 -0.5528 -0.8808 1561441 Maybridge1_006239 CC(=O)Nc1ccc(cc1)c2cc(C(=O)O)c3ccccc3n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D14 compound treatment 919360.0 20300.0 0.12 814100.0 -129000.0 -0.65 778890.0 -126514.333333333 -0.696499351262481 812500.0 -46674.193548387 -0.278499588954243 -0.7524 -0.7549 2072675 Maybridge1_006240 FC(F)(F)c1cccc(c1)N2CCCC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D15 compound treatment 824120.0 -74900.0 -0.43 809760.0 -134000.0 -0.67 716500.0 -188904.333333333 -1.03997501429881 776720.0 -82454.193548387 -0.491994767664774 -1.3138 -0.9402 1509391 Maybridge1_006241 OC(=O)CC(CC(=O)O)c1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D16 compound treatment 831590.0 -67400.0 -0.39 782320.0 -161000.0 -0.8 736270.0 -169134.333333333 -0.931135234554812 792740.0 -66434.193548387 -0.396405255005671 -1.2589 -0.933 1177095 Maybridge1_006242 Cc1cc(O)cc2OC(C)(C)CC(=O)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D17 compound treatment 419060.0 -480000.0 -2.74 444640.0 -499000.0 -2.49 374570.0 -530834.333333333 -2.92240222157584 432570.0 -426604.193548387 -2.54549856177403 -5.3518 -0.998 1384385 Maybridge1_006243 Clc1cc(Cl)c2cccnc2c1OC(=O)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D18 compound treatment 800860.0 -98200.0 -0.56 774150.0 -169000.0 -0.85 641250.0 -264154.333333333 -1.45424883451815 756380.0 -102794.193548387 -0.613361227557792 -1.7371 -0.9258 2072676 Maybridge1_006244 [O-][N+](=O)c1cc(ccc1Sc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D19 compound treatment 966570.0 67500.0 0.39 901870.0 -41400.0 -0.21 853310.0 -52094.333333333 -0.28679492999042 789130.0 -70044.193548387 -0.417945713226605 -0.263 -0.3926 2072677 Maybridge1_006245 CCOC(=O)Cc1ccccc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D20 compound treatment 35170.0 -864000.0 -4.93 35400.0 -908000.0 -4.54 33250.0 -872154.333333333 -4.80147119589161 36430.0 -822744.193548387 -4.90922075558034 -9.5931 -0.9995 2072678 Maybridge1_006246 Cn1c(Sc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])nnc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D21 compound treatment 807740.0 -91300.0 -0.52 794990.0 -148000.0 -0.74 744070.0 -161334.333333333 -0.88819389505035 769550.0 -89624.193548387 -0.534777339809953 -1.343 -0.9752 2072679 Maybridge1_006247 N/N=C/1\C(=O)Nc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D22 compound treatment 791600.0 -107000.0 -0.61 735630.0 -208000.0 -1.04 707910.0 -197494.333333333 -1.08726554075309 710970.0 -148204.193548387 -0.884317517810593 -1.8119 -0.9799 2072680 Maybridge1_006248 COc1ccccc1C2CCN(CC2)C(=O)c3cccc(c3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D23 mock treatment 857980.0 -41100.0 -0.23 825340.0 -118000.0 -0.59 815860.0 -89544.333333333 -0.492968412611203 831300.0 -27874.193548387 -0.16632213339924 -0.7418 -0.9039 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 D24 mock treatment 1048530.0 149000.0 0.85 956640.0 13400.0 0.07 865600.0 -39804.333333333 -0.21913479377121 928640.0 69465.806451613 0.414494543394586 0.5581 0.5715 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E01 compound treatment 809180.0 -89900.0 -0.51 821040.0 -122000.0 -0.61 822560.0 -82844.333333333 -0.456082903036858 946840.0 87665.806451613 0.523091867389322 -0.5288 -0.4999 2072681 Maybridge1_006249 Clc1cccc(Cl)c1c2nsc(=O)o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E02 compound treatment 964030.0 65000.0 0.37 816840.0 -126000.0 -0.63 822640.0 -82764.333333333 -0.45564247904194 935390.0 76215.806451613 0.454771023447578 -0.1309 -0.1342 2072682 Maybridge1_006250 NC(=O)c1ccc(OCC(F)(F)F)nc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E03 compound treatment 529720.0 -369000.0 -2.11 510580.0 -433000.0 -2.16 489000.0 -416404.333333333 -2.29243074984563 535270.0 -323904.193548387 -1.93269937637516 -4.2495 -0.9982 1004151 Maybridge1_006251 NC(=O)c1ccc(o1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E04 compound treatment 472600.0 -426000.0 -2.44 455430.0 -488000.0 -2.44 379950.0 -525454.333333333 -2.89278370791763 471920.0 -387254.193548387 -2.31070160027992 -5.0397 -0.9962 1031001 Maybridge1_006252 Oc1ccccc1C(=O)CC(=O)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E05 compound treatment 797960.0 -101000.0 -0.58 719090.0 -224000.0 -1.12 724180.0 -181224.333333333 -0.997694310786729 728540.0 -130634.193548387 -0.779479331954136 -1.7379 -0.9725 2072683 Maybridge1_006253 NC(=S)c1ccc(cc1)C2SCCS2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E06 compound treatment 904660.0 5630.0 0.03 777160.0 -166000.0 -0.83 822910.0 -82494.333333333 -0.454156048059093 804000.0 -55174.193548387 -0.329218119391345 -0.791 -0.7887 1735704 Maybridge1_006254 O=c1[nH]c2c(C#N)cnn2c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E07 compound treatment 945250.0 46200.0 0.26 847010.0 -96300.0 -0.48 771300.0 -134104.333333333 -0.738284577780285 886740.0 27565.806451613 0.164482022769341 -0.3956 -0.4233 2072684 Maybridge1_006255 CSc1nc(N)nc(n1)C(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E08 compound treatment 818780.0 -80300.0 -0.46 842950.0 -100000.0 -0.5 763300.0 -142104.333333333 -0.782326977272041 789370.0 -69804.193548387 -0.416513660602498 -1.0795 -0.9665 1419577 Maybridge1_006256 Oc1c(c2ccccc2)c(=O)n3c4CCCCc4c5cccc1c53 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E09 compound treatment 857800.0 -41200.0 -0.24 818410.0 -125000.0 -0.62 771580.0 -133824.333333333 -0.736743093798074 794680.0 -64494.193548387 -0.384829496294144 -0.9908 -0.9295 1301788 Maybridge1_006257 CSc1nc(N)nc(n1)N2CCCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E10 compound treatment 808930.0 -90100.0 -0.51 770880.0 -172000.0 -0.86 719650.0 -185754.333333333 -1.02263331949894 812180.0 -46994.193548387 -0.280408992453051 -1.34 -0.9175 2072685 Maybridge1_006258 CCOC(=O)c1ccc2nc(/N=C/N(C)C)sc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E11 compound treatment 629920.0 -269000.0 -1.54 618030.0 -325000.0 -1.63 569390.0 -336014.333333333 -1.84985968795285 644330.0 -214844.193548387 -1.28195079643747 -3.1479 -0.9918 2072686 Maybridge1_006259 Cc1nc(N)nc(N/N=C/c2ccccc2O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E12 compound treatment 1041170.0 142000.0 0.81 817960.0 -125000.0 -0.63 753700.0 -151704.333333333 -0.835177856662149 816040.0 -43134.193548387 -0.257376812748673 -0.4537 -0.3367 2072687 Maybridge1_006260 Oc1ncnc2ccc(Br)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E13 compound treatment 954880.0 55800.0 0.32 1293790.0 351000.0 1.75 798560.0 -106844.333333333 -0.588210101512126 1123630.0 264455.806451613 1.57797763162171 1.531 0.6244 2072688 Maybridge1_006261 FC(F)(F)C(=O)NNC(=O)c1ccc[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E14 compound treatment 800160.0 -98900.0 -0.56 795730.0 -148000.0 -0.74 899420.0 -5984.33333333302 -0.0329455499198107 722080.0 -137094.193548387 -0.818025415086334 -1.0768 -0.8695 2072689 Maybridge1_006262 Cc1ccc2ncnc(Oc3ncccc3[N+](=O)[O-])c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E15 compound treatment 819400.0 -79600.0 -0.45 796450.0 -147000.0 -0.73 780170.0 -125234.333333333 -0.6894525673438 757150.0 -102024.193548387 -0.608766725388784 -1.2437 -0.9857 2072690 Maybridge1_006263 Clc1cccc(CN2C(=O)CNC2=S)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E16 compound treatment 846330.0 -52700.0 -0.3 884930.0 -58300.0 -0.29 767620.0 -137784.333333333 -0.758544081546493 766080.0 -93094.193548387 -0.555482434000158 -0.9534 -0.9262 2072691 Maybridge1_006264 CCOC(=O)c1cnn(c1N)c2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E17 compound treatment 860400.0 -38600.0 -0.22 981240.0 38000.0 0.19 826740.0 -78664.333333333 -0.433070749302415 798240.0 -60934.193548387 -0.363587382369899 -0.4137 -0.6504 1330771 Maybridge1_006265 CC(C)NC(=O)N(Cc1cccnc1)Cc2cccc(Cl)c2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E18 compound treatment 842660.0 -56400.0 -0.32 800800.0 -142000.0 -0.71 817810.0 -87594.333333333 -0.482233077735088 864260.0 5085.80645161297 0.0303464269780403 -0.7432 -0.8086 2072692 Maybridge1_006266 COc1ccc2[nH]c(S)nc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E19 compound treatment 959940.0 60900.0 0.35 805390.0 -138000.0 -0.69 831140.0 -74264.333333333 -0.408847429581949 802930.0 -56244.193548387 -0.335602687340486 -0.5431 -0.5801 2072693 Maybridge1_006267 OC(=O)c1cnccc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E20 compound treatment 870780.0 -28300.0 -0.16 754320.0 -189000.0 -0.95 700160.0 -205244.333333333 -1.12993161526073 788490.0 -70684.193548387 -0.421764520224222 -1.3291 -0.8626 1049568 Maybridge1_006268 CC(=O)N1CCc2cc(ccc12)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E21 compound treatment 754660.0 -144000.0 -0.82 746760.0 -197000.0 -0.98 711060.0 -194344.333333333 -1.06992384595321 765400.0 -93774.193548387 -0.559539916435126 -1.7185 -0.9754 2072694 Maybridge1_006269 CCOC(=O)c1csc(n1)c2ccc(cc2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E22 compound treatment 507910.0 -391000.0 -2.23 533790.0 -409000.0 -2.05 453650.0 -451754.333333333 -2.48704310259983 493140.0 -366034.193548387 -2.18408428076518 -4.4767 -0.9975 2072695 Maybridge1_006270 Oc1ccc2ccccc2c1C(/N=C/c3ccc(cc3)C(F)(F)F)c4ccc(cc4)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E23 mock treatment 906450.0 7420.0 0.04 845480.0 -97800.0 -0.49 842810.0 -62594.333333333 -0.34460057932335 810440.0 -48734.193548387 -0.290791373977823 -0.541 -0.8117 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 E24 mock treatment 881790.0 -17200.0 -0.1 1149120.0 206000.0 1.03 1171490.0 266085.666666667 1.46488140379545 809950.0 -49224.193548387 -0.293715148085373 1.0511 0.5785 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F01 compound treatment 855120.0 -43900.0 -0.25 787640.0 -156000.0 -0.78 784980.0 -120424.333333333 -0.662972074649382 827200.0 -31974.193548387 -0.190786365727725 -0.9415 -0.88 2072696 Maybridge1_006271 Cc1ccc(cc1)C(=O)c2ccccc2[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F02 compound treatment 812610.0 -86400.0 -0.49 813390.0 -130000.0 -0.65 734820.0 -170584.333333333 -0.939117919462693 747210.0 -111964.193548387 -0.668077571570525 -1.3752 -0.9739 1667943 Maybridge1_006272 OC(=O)CCNc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F03 compound treatment 774290.0 -125000.0 -0.71 804520.0 -139000.0 -0.69 737440.0 -167964.333333333 -0.924694033629143 727150.0 -132024.193548387 -0.787773303402086 -1.5595 -0.9933 1351203 Maybridge1_006273 CCOC(=O)COc1cccc2c(C)cc(=O)oc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F04 compound treatment 793530.0 -106000.0 -0.6 768290.0 -175000.0 -0.88 740980.0 -164424.333333333 -0.905205271854041 748330.0 -110844.193548387 -0.661394659324695 -1.5222 -0.9855 1028837 Maybridge1_006274 OC1(Cc2ccccn2)C(=O)Nc3ccccc31 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F05 compound treatment 757540.0 -141000.0 -0.81 730100.0 -213000.0 -1.07 680420.0 -224984.333333333 -1.23860623600663 698570.0 -160604.193548387 -0.958306903389425 -2.0357 -0.9883 2072697 Maybridge1_006275 CC(=O)c1ccc(OCc2ccccc2)cc1OCc3ccc(F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F06 compound treatment 845330.0 -53700.0 -0.31 812810.0 -130000.0 -0.65 733760.0 -171644.333333333 -0.944953537395351 745370.0 -113804.193548387 -0.679056641688674 -1.2916 -0.9436 2072698 Maybridge1_006276 CCOC(=O)CC1=Nn2c(nnc2SC1)c3cc(Cl)cc(Cl)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F07 compound treatment 794280.0 -105000.0 -0.6 1183800.0 241000.0 1.2 773570.0 -131834.333333333 -0.725787546924499 898630.0 39455.806451613 0.235428296521946 0.0572 0.037 2072699 Maybridge1_006277 Cc1cc(ccc1[N+](=O)[O-])C(=O)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F08 compound treatment 787480.0 -112000.0 -0.64 815070.0 -128000.0 -0.64 729320.0 -176084.333333333 -0.969397069113275 746240.0 -112934.193548387 -0.673865450926288 -1.4608 -0.9824 1044908 Maybridge1_006278 CCOC(=O)c1cnn(c1N)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F09 compound treatment 759310.0 -140000.0 -0.8 785440.0 -158000.0 -0.79 658890.0 -246514.333333333 -1.35713534363882 693440.0 -165734.193548387 -0.988917028229699 -1.9668 -0.9737 2072700 Maybridge1_006279 CCCCCc1ccc(cc1)C(=O)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F10 compound treatment 826670.0 -72400.0 -0.41 833570.0 -110000.0 -0.55 655480.0 -249924.333333333 -1.37590841642218 750240.0 -108934.193548387 -0.649997907191181 -1.494 -0.8948 2072701 Maybridge1_006280 O/N=C/Nc1nc-2c(CCc3ccccc23)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F11 compound treatment 565390.0 -334000.0 -1.91 513810.0 -429000.0 -2.15 627710.0 -277694.333333333 -1.52879059565794 549540.0 -309634.193548387 -1.84755191410017 -3.7151 -0.993 1060684 Maybridge1_006281 C1CCCc2c(CC1)[nH]c3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F12 compound treatment 794350.0 -105000.0 -0.6 770150.0 -173000.0 -0.87 674720.0 -230684.333333333 -1.26998644564451 783910.0 -75264.193548387 -0.449092857800919 -1.5915 -0.931 2072702 Maybridge1_006282 COc1ccc2-c3nc(/N=C/c4ccc(cc4)C(F)(F)F)sc3CCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F13 compound treatment 849200.0 -49800.0 -0.28 811530.0 -132000.0 -0.66 811420.0 -93984.333333333 -0.517411944329128 803390.0 -55784.193548387 -0.332857919810949 -0.8969 -0.9488 1049405 Maybridge1_006283 CS(=O)(=O)c1ccc(cc1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F14 compound treatment 810290.0 -88700.0 -0.51 787780.0 -155000.0 -0.78 769770.0 -135634.333333333 -0.746707686683083 777570.0 -81604.193548387 -0.486922914621064 -1.2591 -0.9783 2072703 Maybridge1_006284 C1Oc2ccc(/C=N/c3nc-4c(CCc5ccccc45)s3)cc2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F15 compound treatment 850030.0 -49000.0 -0.28 797360.0 -146000.0 -0.73 785280.0 -120124.333333333 -0.661320484668441 804740.0 -54434.193548387 -0.32480262380035 -0.9979 -0.929 2072704 Maybridge1_006285 Clc1ccc(cc1)C2CC(=O)NC(=O)C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F16 compound treatment 854740.0 -44300.0 -0.25 820490.0 -123000.0 -0.61 793190.0 -112214.333333333 -0.617773562170967 833410.0 -25764.193548387 -0.153732004078972 -0.8193 -0.8906 2072705 Maybridge1_006286 COc1ccc(C)nc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F17 compound treatment 874970.0 -24100.0 -0.14 855200.0 -88100.0 -0.44 791210.0 -114194.333333333 -0.628674056045177 839440.0 -19734.193548387 -0.117751681898298 -0.6622 -0.8396 2072706 Maybridge1_006287 OC(=O)c1cc(ccc1Sc2ccc(cc2C(=O)O)[N+](=O)[O-])[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F18 compound treatment 637790.0 -261000.0 -1.49 607240.0 -336000.0 -1.68 642920.0 -262484.333333333 -1.44505498362424 665940.0 -193234.193548387 -1.15300639140856 -2.8855 -0.9915 1620619 Maybridge1_006288 Cc1c(OCc2ccccc2F)ccc3C(=O)CC(C)(C)Oc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F19 compound treatment 796340.0 -103000.0 -0.59 788660.0 -155000.0 -0.77 733040.0 -172364.333333333 -0.948917353349609 750280.0 -108894.193548387 -0.64975923175383 -1.4793 -0.983 1102313 Maybridge1_006289 Clc1cc2nc[nH]c2cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F20 compound treatment 795210.0 -104000.0 -0.59 756710.0 -187000.0 -0.93 735370.0 -170034.333333333 -0.936090004497635 760480.0 -98694.193548387 -0.588896995229308 -1.5256 -0.9756 2072707 Maybridge1_006290 CC(=O)COc1ccc2C(=O)CC(C)(C)Oc2c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F21 compound treatment 847130.0 -51900.0 -0.3 797490.0 -146000.0 -0.73 796820.0 -108584.333333333 -0.597789323401583 827320.0 -31854.193548387 -0.190070339415672 -0.9067 -0.9009 1017701 Maybridge1_006291 CSc1nc2ccccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F22 compound treatment 835080.0 -64000.0 -0.37 764730.0 -179000.0 -0.89 760000.0 -145404.333333333 -0.800494467062391 769060.0 -90114.193548387 -0.537701113917504 -1.2982 -0.9517 1781380 Maybridge1_006292 COc1ccccc1N2CCN(CC2)C(=O)c3cccc(c3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F23 mock treatment 881780.0 -17300.0 -0.1 1028070.0 84800.0 0.42 891200.0 -14204.333333333 -0.0781991153975901 836860.0 -22314.193548387 -0.133146247607442 0.0571 0.1237 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 F24 mock treatment 904490.0 5460.0 0.03 903680.0 -39600.0 -0.2 813790.0 -91614.333333333 -0.504364383479695 754150.0 -105024.193548387 -0.626667383190115 -0.6489 -0.7828 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G01 compound treatment 891090.0 -7940.0 -0.05 1008850.0 65600.0 0.33 847930.0 -57474.333333333 -0.316413443648626 1065340.0 206165.806451613 1.23016785054186 0.5982 0.4557 2072708 Maybridge1_006293 NC(=N)C1(CC2CC3CC(C2)C1)C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G02 compound treatment 830680.0 -68400.0 -0.39 795890.0 -147000.0 -0.74 787110.0 -118294.333333333 -0.651245785784702 797060.0 -62114.193548387 -0.370628307771755 -1.0747 -0.9585 2072709 Maybridge1_006294 OC(=O)c1cc(OCC(F)(F)F)nc(OCC(F)(F)F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G03 compound treatment 730560.0 -168000.0 -0.96 745950.0 -197000.0 -0.99 692960.0 -212444.333333333 -1.16956977480331 672260.0 -186914.193548387 -1.11529567230709 -2.1171 -0.9967 1166265 Maybridge1_006295 CC(C)c1ccc(Nc2snc(O)c2C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G04 compound treatment 794080.0 -105000.0 -0.6 756260.0 -187000.0 -0.94 754410.0 -150994.333333333 -0.831269093707255 778460.0 -80714.193548387 -0.481612386140002 -1.4239 -0.9694 2072710 Maybridge1_006296 CC(=O)c1ccccc1OC(=O)c2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G05 compound treatment 822500.0 -76500.0 -0.44 792930.0 -150000.0 -0.75 782320.0 -123084.333333333 -0.677616172480391 750330.0 -108844.193548387 -0.649460887457142 -1.2581 -0.9832 2072711 Maybridge1_006297 Clc1ccc(N2C(=N)SCC2=O)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G06 compound treatment 889640.0 -9390.0 -0.05 798690.0 -145000.0 -0.72 778620.0 -126784.333333333 -0.697985782245328 847680.0 -11494.193548387 -0.0685845418039777 -0.7717 -0.7649 2072712 Maybridge1_006298 Cc1[nH]c(=O)[nH]c(=O)c1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G07 compound treatment 796100.0 -103000.0 -0.59 876870.0 -66400.0 -0.33 783750.0 -121654.333333333 -0.66974359357124 796850.0 -62324.193548387 -0.371881353817848 -0.9808 -0.9605 1556343 Maybridge1_006299 CSc1nc(N)nc(n1)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G08 compound treatment 898720.0 -313.0 0.0 817400.0 -126000.0 -0.63 826080.0 -79324.333333333 -0.436704247260485 840960.0 -18214.193548387 -0.108682015278957 -0.5883 -0.7603 2072713 Maybridge1_006300 NC(=O)c1cnn(c1N)c2ccc(F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G09 compound treatment 778800.0 -120000.0 -0.69 784170.0 -159000.0 -0.8 768770.0 -136634.333333333 -0.752212986619553 777250.0 -81924.193548387 -0.488832318119872 -1.3618 -0.9854 2072714 Maybridge1_006301 CCCCNC(=O)NS(=O)(=O)c1ccccc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G10 compound treatment 701920.0 -197000.0 -1.13 730960.0 -212000.0 -1.06 700000.0 -205404.333333333 -1.13081246325056 713560.0 -145614.193548387 -0.868863283242112 -2.0938 -0.9949 2072715 Maybridge1_006302 CCOC(=O)/C(=C/Nc1nc2ccc(cc2s1)C(=O)OCC)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G11 compound treatment 854420.0 -44600.0 -0.25 833970.0 -109000.0 -0.55 854010.0 -51394.333333333 -0.282941220034891 776440.0 -82734.193548387 -0.493665495726231 -0.789 -0.9516 2072716 Maybridge1_006303 CC(C)(C)C(=O)OCC(=S)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G12 compound treatment 1170590.0 272000.0 1.55 775900.0 -167000.0 -0.84 682200.0 -223204.333333333 -1.22880680211972 1075210.0 216035.806451613 1.28906101470824 0.3872 0.1545 1030016 Maybridge1_006304 Oc1ncnc2cc(Cl)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G13 compound treatment 873600.0 -25400.0 -0.15 838350.0 -105000.0 -0.52 831330.0 -74074.333333333 -0.40780142259402 760020.0 -99154.193548387 -0.591641762758845 -0.8347 -0.9259 1714880 Maybridge1_006305 O=C1CNC(=S)N1Cc2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G14 compound treatment 762810.0 -136000.0 -0.78 773940.0 -169000.0 -0.85 1049810.0 144405.666666667 0.79499650752584 692760.0 -166414.193548387 -0.992974510664667 -0.9115 -0.5315 2072717 Maybridge1_006306 CC(C)(C)c1ccc(cc1)c2ncc(s2)c3cccc(c3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G15 compound treatment 827220.0 -71800.0 -0.41 802770.0 -140000.0 -0.7 755810.0 -149594.333333333 -0.823561673796198 767550.0 -91624.193548387 -0.546711111677506 -1.2416 -0.9698 1083878 Maybridge1_006307 Clc1ccc(OCC#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G16 compound treatment 765710.0 -133000.0 -0.76 754240.0 -189000.0 -0.95 699360.0 -206044.333333333 -1.1343358552099 744960.0 -114214.193548387 -0.681503064921523 -1.7614 -0.9808 2072718 Maybridge1_006308 CCOC(=O)c1cnn(c1n2cccc2)c3ccc(cc3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G17 compound treatment 894040.0 -4990.0 -0.03 745600.0 -198000.0 -0.99 782760.0 -122644.333333333 -0.675193840508344 817920.0 -41254.193548387 -0.246159067193173 -0.9693 -0.7928 2072719 Maybridge1_006309 CSC1=NCC(=O)N1CCc2c[nH]c3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G18 compound treatment 870360.0 -28700.0 -0.16 820060.0 -123000.0 -0.62 825870.0 -79534.333333333 -0.437860360247144 724380.0 -134794.193548387 -0.804301577438648 -1.0111 -0.9061 1666680 Maybridge1_006310 CCOC(=O)c1cc(=O)c2ccc(OC(=O)c3sc4ccccc4c3Cl)cc2o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G19 compound treatment 800380.0 -98700.0 -0.56 912560.0 -30700.0 -0.15 900330.0 -5074.33333333302 -0.0279357269776234 747360.0 -111814.193548387 -0.667182538680458 -0.7061 -0.7959 2072720 Maybridge1_006311 NC(=O)C1=CNCCC1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G20 compound treatment 856570.0 -42500.0 -0.24 786840.0 -156000.0 -0.78 737680.0 -167724.333333333 -0.92337276164439 669930.0 -189244.193548387 -1.12919851653279 -1.5387 -0.9198 2072721 Maybridge1_006312 [O-][N+](=O)c1ccc2N(CCc2c1)C(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G21 compound treatment 847410.0 -51600.0 -0.29 766250.0 -177000.0 -0.89 774630.0 -130774.333333333 -0.719951928991842 778820.0 -80354.193548387 -0.479464307203843 -1.1898 -0.9351 2072722 Maybridge1_006313 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nc(CSc3ncccn3)no2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G22 compound treatment 785170.0 -114000.0 -0.65 756340.0 -187000.0 -0.93 750880.0 -154524.333333333 -0.850702802482993 730850.0 -128324.193548387 -0.765695825447112 -1.6009 -0.9915 1603340 Maybridge1_006314 Oc1cc(=O)n2CCc3cccc1c32 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G23 mock treatment 877450.0 -21600.0 -0.12 811430.0 -132000.0 -0.66 801320.0 -104084.333333333 -0.57301547368747 703370.0 -155804.193548387 -0.929665850907296 -1.1427 -0.8916 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 G24 mock treatment 881940.0 -17100.0 -0.1 1037520.0 94300.0 0.47 1079570.0 174165.666666667 0.958834233635173 837360.0 -21814.193548387 -0.130162804640553 0.6012 0.5563 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H01 compound treatment 826720.0 -72300.0 -0.41 840730.0 -103000.0 -0.51 802530.0 -102874.333333333 -0.566354060764342 859640.0 465.806451612967 0.00277941396399186 -0.7447 -0.8574 2072723 Maybridge1_006315 CSc1c(C#N)c(N)[nH]c(=S)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H02 compound treatment 711060.0 -188000.0 -1.07 693120.0 -250000.0 -1.25 665760.0 -239644.333333333 -1.31931393307528 692850.0 -166324.193548387 -0.992437490930628 -2.3183 -0.9936 2072724 Maybridge1_006316 Nc1ccc(cc1)c2nnc(Nc3ccccc3C(F)(F)F)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H03 compound treatment 748810.0 -150000.0 -0.86 759090.0 -184000.0 -0.92 696600.0 -208804.333333333 -1.14953048303456 669310.0 -189864.193548387 -1.13289798581173 -2.0309 -0.9922 2072725 Maybridge1_006317 CC(=O)c1cc(F)ccc1OCc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H04 compound treatment 829060.0 -70000.0 -0.4 760640.0 -183000.0 -0.91 735640.0 -169764.333333333 -0.934603573514788 786620.0 -72554.193548387 -0.432922596920384 -1.3403 -0.935 1285144 Maybridge1_006318 OC1(Cc2ccncc2)C(=O)Nc3ccccc31 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H05 compound treatment 861050.0 -38000.0 -0.22 790160.0 -153000.0 -0.77 755520.0 -149884.333333333 -0.825158210777774 780490.0 -78684.193548387 -0.469499607694436 -1.1387 -0.9191 1112292 Maybridge1_006319 COc1ccc(Cl)cc1NC(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H06 compound treatment 763370.0 -136000.0 -0.77 902630.0 -40600.0 -0.2 837190.0 -68214.333333333 -0.375540364966309 754630.0 -104544.193548387 -0.623803277941902 -0.9888 -0.9133 2072726 Maybridge1_006320 [O-][N+](=O)c1ccc(cc1)C(=O)Nc2nc-3c(CCc4ccccc34)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H07 compound treatment 822290.0 -76700.0 -0.44 806510.0 -137000.0 -0.68 1003210.0 97805.666666667 0.53844953048636 845410.0 -13764.193548387 -0.0821293728736509 -0.333 -0.3405 2072727 Maybridge1_006321 OC(=O)C1CC(CC(C1)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H08 compound treatment 751070.0 -148000.0 -0.85 776800.0 -166000.0 -0.83 771080.0 -134324.333333333 -0.739495743766308 704800.0 -154374.193548387 -0.921133204021996 -1.6692 -0.997 2072728 Maybridge1_006322 CN(C)/C=N/c1nc-2c(CCc3ccccc23)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H09 compound treatment 779370.0 -120000.0 -0.68 768670.0 -175000.0 -0.87 740370.0 -165034.333333333 -0.908563504815287 722240.0 -136934.193548387 -0.81707071333693 -1.6412 -0.9946 1425686 Maybridge1_006323 CCCCn1c(=O)c(C)c(C)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H10 compound treatment 735580.0 -163000.0 -0.93 720320.0 -223000.0 -1.12 662790.0 -242614.333333333 -1.33566467388659 670480.0 -188694.193548387 -1.12591672926921 -2.2552 -0.9921 2072729 Maybridge1_006324 CC(C)/C=C/C1=CC2=C(C1)Cc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H11 compound treatment 484820.0 -414000.0 -2.37 591780.0 -351000.0 -1.76 531470.0 -373934.333333333 -2.05862066154377 534980.0 -324194.193548387 -1.93442977329596 -4.0586 -0.9941 1556202 Maybridge1_006325 C1CCCCCc2c(CCCC1)[nH]c3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H12 compound treatment 879250.0 -19800.0 -0.11 799040.0 -144000.0 -0.72 751860.0 -153544.333333333 -0.845307608545252 814940.0 -44234.193548387 -0.263940387275828 -0.9718 -0.8467 2072730 Maybridge1_006326 S=C1NCN(CCCCc2ccccc2)CN1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H13 compound treatment 32900.0 -866000.0 -4.95 42180.0 -901000.0 -4.51 32500.0 -872904.333333333 -4.80560017084396 34030.0 -825144.193548387 -4.92354128182141 -9.5919 -0.9993 2072731 Maybridge1_006327 [O-][N+](=O)/C=C/c1cc2OCOc2cc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H14 compound treatment 738560.0 -160000.0 -0.92 967410.0 24100.0 0.12 732530.0 -172874.333333333 -0.951725056317208 740430.0 -118744.193548387 -0.708533058201531 -1.2281 -0.8164 1266526 Maybridge1_006328 Cc1ccc(cc1)S(=O)(=O)c2ccc(Cl)c(N)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H15 compound treatment 630600.0 -268000.0 -1.53 593980.0 -349000.0 -1.75 577440.0 -327964.333333333 -1.80554202346427 527580.0 -331594.193548387 -1.97858472920591 -3.5323 -0.996 1053450 Maybridge1_006329 Cc1ccc2[nH]c3CCCCc3c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H16 compound treatment 889600.0 -9430.0 -0.05 770100.0 -173000.0 -0.87 766970.0 -138434.333333333 -0.762122526505198 871560.0 12385.806451613 0.0739046942946104 -0.8041 -0.6948 2072732 Maybridge1_006330 [O-][N+](=O)c1ccc(cc1)C(=O)Nc2cccc(c2)C(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H17 compound treatment 852320.0 -46700.0 -0.27 827420.0 -116000.0 -0.58 789080.0 -116324.333333333 -0.640400344909857 820760.0 -38414.193548387 -0.229213111141247 -0.8579 -0.92 1411302 Maybridge1_006331 COC(=O)COc1c(Br)cc(Br)cc1C(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H18 compound treatment 768920.0 -130000.0 -0.74 787120.0 -156000.0 -0.78 734610.0 -170794.333333333 -0.940274032449352 760720.0 -98454.193548387 -0.587464942605201 -1.526 -0.9868 2072733 Maybridge1_006332 Cc1c(OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)ccc3C(=O)CC(C)(C)Oc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H19 compound treatment 806130.0 -92900.0 -0.53 997500.0 54200.0 0.27 713690.0 -191714.333333333 -1.05544490712029 784500.0 -74674.193548387 -0.445572395099991 -0.8802 -0.6816 2072734 Maybridge1_006333 Clc1ccc2C(=O)N(Cc3ccccc3)C(=O)c4cccc1c42 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H20 compound treatment 342610.0 -556000.0 -3.18 471580.0 -472000.0 -2.36 411110.0 -494294.333333333 -2.72123856189724 387840.0 -471334.193548387 -2.81239736959187 -5.5357 -0.9945 2072735 Maybridge1_006334 Cn1c(Sc2ccc(cn2)[N+](=O)[O-])nnc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H21 compound treatment 818030.0 -81000.0 -0.46 761830.0 -181000.0 -0.91 788110.0 -117294.333333333 -0.645740485848233 732770.0 -126404.193548387 -0.754239404454261 -1.3851 -0.9737 2072736 Maybridge1_006335 CC(C)(C)c1ccc(cc1)C(=O)NNC(=O)c2ccc(cc2)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H22 compound treatment 832390.0 -66600.0 -0.38 951910.0 8650.0 0.04 886180.0 -19224.333333333 -0.105835721078667 774490.0 -84684.193548387 -0.505300923297096 -0.4743 -0.7377 1015808 Maybridge1_006336 Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)CO)c2cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H23 mock treatment 906160.0 7130.0 0.04 890980.0 -52300.0 -0.26 913060.0 7655.66666666698 0.0421467412136335 861540.0 2365.80645161297 0.0141164972381676 -0.0823 -0.3065 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 H24 mock treatment 928240.0 29200.0 0.17 1078080.0 135000.0 0.67 1028770.0 123365.666666667 0.679164996862521 879460.0 20285.806451613 0.121043093171446 0.8207 0.8383 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I01 compound treatment 861030.0 -38000.0 -0.22 971590.0 28300.0 0.14 778400.0 -127004.333333333 -0.699196948231351 997890.0 138715.806451613 0.827701394308624 0.0265 0.0238 1681466 Maybridge1_006337 Cc1cc(O)nc(n1)C2(CC3CC4CC(C3)C2)C4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I02 compound treatment 883620.0 -15400.0 -0.09 769920.0 -173000.0 -0.87 765360.0 -140044.333333333 -0.770986059402914 824700.0 -34474.193548387 -0.205703580562167 -0.9659 -0.8174 2072737 Maybridge1_006338 FC(F)(F)c1ccc[nH]c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I03 compound treatment 775210.0 -124000.0 -0.71 702580.0 -241000.0 -1.2 671940.0 -233464.333333333 -1.2852911794679 703750.0 -155424.193548387 -0.927398434252461 -2.0619 -0.9762 2072738 Maybridge1_006339 Oc1nsc(Nc2ccccc2C(F)(F)F)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I04 compound treatment 793960.0 -105000.0 -0.6 792710.0 -151000.0 -0.75 758460.0 -146944.333333333 -0.808972628964554 800690.0 -58484.193548387 -0.348968511832146 -1.2556 -0.962 1040552 Maybridge1_006340 OC(=O)C1c2ccccc2Oc3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I05 compound treatment 841340.0 -57700.0 -0.33 806790.0 -136000.0 -0.68 806010.0 -99394.333333333 -0.547195616985428 844020.0 -15154.193548387 -0.0904233443216005 -0.8249 -0.8783 2072739 Maybridge1_006341 Fc1ccc(cc1Cl)N2C(=N)SCC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I06 compound treatment 847870.0 -51200.0 -0.29 823630.0 -120000.0 -0.6 736870.0 -168534.333333333 -0.927832054592931 730030.0 -129144.193548387 -0.770588671912809 -1.2945 -0.9396 1033843 Maybridge1_006342 O=C1CCC(=NN1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I07 compound treatment 800960.0 -98100.0 -0.56 821410.0 -122000.0 -0.61 763750.0 -141654.333333333 -0.77984959230063 763380.0 -95794.193548387 -0.571593026021355 -1.2606 -0.9903 2072740 Maybridge1_006343 CSc1nc(N)nc(n1)C2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I08 compound treatment 883070.0 -16000.0 -0.09 831150.0 -112000.0 -0.56 752800.0 -152604.333333333 -0.840132626604971 815870.0 -43304.193548387 -0.258391183357415 -0.8752 -0.8363 1335096 Maybridge1_006344 CCC(=O)Nc1ccc(OC)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I09 compound treatment 842510.0 -56500.0 -0.32 803740.0 -140000.0 -0.7 762890.0 -142514.333333333 -0.784584150245994 812360.0 -46814.193548387 -0.279334952984972 -1.0423 -0.9196 1713393 Maybridge1_006345 CSc1nc(N)nc(n1)N2CCCCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I10 compound treatment 793770.0 -105000.0 -0.6 793920.0 -149000.0 -0.75 745570.0 -159834.333333333 -0.879935945145646 779890.0 -79284.193548387 -0.473079739254702 -1.3506 -0.9753 2072741 Maybridge1_006346 CCOC(=O)c1ccc2nc(sc2c1)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I11 compound treatment 793850.0 -105000.0 -0.6 792180.0 -151000.0 -0.76 734530.0 -170874.333333333 -0.940714456444269 792890.0 -66284.193548387 -0.395510222115604 -1.3464 -0.9584 2072742 Maybridge1_006347 CC(C)(C)C(=O)OC/C(=N/OC(=O)c1ccccc1)/N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I12 compound treatment 826660.0 -72400.0 -0.41 781600.0 -162000.0 -0.81 749560.0 -155844.333333333 -0.857969798399132 782430.0 -76744.193548387 -0.457923848982909 -1.2689 -0.9537 1189503 Maybridge1_006348 NC(=O)c1cccnc1Oc2ccc(Cl)cc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I13 compound treatment 859570.0 -39500.0 -0.23 1051230.0 108000.0 0.54 726180.0 -179224.333333333 -0.98668371091379 771430.0 -87744.193548387 -0.523559594254453 -0.5978 -0.4741 1373573 Maybridge1_006349 O=C1CNC(=S)N1Cc2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I14 compound treatment 827740.0 -71300.0 -0.41 834030.0 -109000.0 -0.55 911380.0 5975.66666666698 0.0328978373203647 802450.0 -56724.193548387 -0.338466792588699 -0.6296 -0.8267 1032780 Maybridge1_006350 COC(=O)COc1ccc(cc1)C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I15 compound treatment 817610.0 -81400.0 -0.47 839200.0 -104000.0 -0.52 748160.0 -157244.333333333 -0.86567721831019 735810.0 -123364.193548387 -0.73610007121558 -1.2937 -0.9701 2072743 Maybridge1_006351 Cc1cc(NCc2cccc(Cl)c2Cl)no1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I16 compound treatment 798400.0 -101000.0 -0.57 804670.0 -139000.0 -0.69 760920.0 -144484.333333333 -0.795429591120839 749140.0 -110034.193548387 -0.656561481718336 -1.36 -0.9933 2072744 Maybridge1_006352 CN(C)/C=C/c1ccc(cc1[N+](=O)[O-])[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I17 compound treatment 787840.0 -111000.0 -0.64 766740.0 -177000.0 -0.88 823430.0 -81974.333333333 -0.451293292092129 741230.0 -117944.193548387 -0.70375954945451 -1.3366 -0.9743 1331627 Maybridge1_006353 COC(=O)c1cc(Cl)cc2SS(=O)Nc21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I18 compound treatment 827200.0 -71800.0 -0.41 753460.0 -190000.0 -0.95 757880.0 -147524.333333333 -0.812165702927706 860840.0 1665.80645161297 0.00993967708452393 -1.0809 -0.822 1524120 Maybridge1_006354 CCOC(=O)c1cc(=O)c2ccc(OC(=O)c3cccnc3Oc4ccccc4)cc2o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I19 compound treatment 862370.0 -36700.0 -0.21 786570.0 -157000.0 -0.78 775200.0 -130204.333333333 -0.716813908028054 789160.0 -70014.193548387 -0.417766706648591 -1.0639 -0.9168 2072745 Maybridge1_006355 FC(F)(F)c1ccncc1C(=O)Nc2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I20 compound treatment 618040.0 -281000.0 -1.61 788960.0 -154000.0 -0.77 552320.0 -353084.333333333 -1.94383515786838 537020.0 -322154.193548387 -1.92225732599105 -3.1215 -0.9567 2072746 Maybridge1_006356 CC(=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(C)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I21 compound treatment 829020.0 -70000.0 -0.4 769210.0 -174000.0 -0.87 741920.0 -163484.333333333 -0.900030289913759 736590.0 -122584.193548387 -0.731445900187234 -1.451 -0.9646 2072747 Maybridge1_006357 COC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I22 compound treatment 700120.0 -199000.0 -1.14 724090.0 -219000.0 -1.1 668930.0 -236474.333333333 -1.30186213227667 656900.0 -202274.193548387 -1.2069470402499 -2.3706 -0.9978 2072748 Maybridge1_006358 O=C/1/C(=C/c2ccccc2)/CCC\C1=C/c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I23 mock treatment 866400.0 -32600.0 -0.19 967880.0 24600.0 0.12 918150.0 12745.666666667 0.0701687178902633 775040.0 -84134.193548387 -0.502019136033519 -0.2476 -0.4469 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 I24 mock treatment 882460.0 -16600.0 -0.09 1021310.0 78000.0 0.39 1106960.0 201555.666666667 1.10962439889507 815290.0 -43884.193548387 -0.261851977199006 0.5717 0.473 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J01 compound treatment 814400.0 -84600.0 -0.48 788810.0 -154000.0 -0.77 859810.0 -45594.333333333 -0.251010480403368 752710.0 -106464.193548387 -0.635259698934753 -1.0711 -0.9405 2072749 Maybridge1_006359 COc1ccc([N+](=O)[O-])c(SC(C)C(=O)O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J02 compound treatment 714960.0 -184000.0 -1.05 647200.0 -296000.0 -1.48 623250.0 -282154.333333333 -1.5533442333746 698470.0 -160704.193548387 -0.958903591982802 -2.5223 -0.9795 2072750 Maybridge1_006360 Cc1ccc(OCC(=O)NNC(=O)NC(=O)c2ccccc2Cl)c3CCCc31 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J03 compound treatment 783070.0 -116000.0 -0.66 761550.0 -182000.0 -0.91 852740.0 -52664.333333333 -0.289932950954208 764640.0 -94534.193548387 -0.564074749744797 -1.2126 -0.9392 1463171 Maybridge1_006361 Cc1ccc(OCC(=O)NN)c2CCCc21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J04 compound treatment 817440.0 -81600.0 -0.47 796490.0 -147000.0 -0.73 766280.0 -139124.333333333 -0.765921183461362 763130.0 -96044.193548387 -0.5730847475048 -1.2696 -0.9821 1712700 Maybridge1_006362 OC1(Cc2ccccn2)C(=O)Nc3ccc(Br)cc31 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J05 compound treatment 738750.0 -160000.0 -0.92 811140.0 -132000.0 -0.66 819110.0 -86294.333333333 -0.475076187817678 765200.0 -93974.193548387 -0.560733293621882 -1.3061 -0.9695 1158376 Maybridge1_006363 O=C(C(C(=O)N1CCc2ccccc12)c3ccccc3)N4CCc5ccccc45 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J06 compound treatment 782630.0 -116000.0 -0.66 867910.0 -75400.0 -0.38 743360.0 -162044.333333333 -0.892102658005243 786740.0 -72434.193548387 -0.432206570608331 -1.1831 -0.9451 2072751 Maybridge1_006364 [O-][N+](=O)c1ccc(cc1)C(=O)Nc2nc-3c(Cc4ccccc34)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J07 compound treatment 832200.0 -66800.0 -0.38 775680.0 -168000.0 -0.84 675740.0 -229664.333333333 -1.26437103970931 759840.0 -99334.193548387 -0.592715802226925 -1.5385 -0.9197 1201826 Maybridge1_006365 CCOC(=O)C1=C(C)NC(=S)NC1c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J08 compound treatment 764370.0 -135000.0 -0.77 737080.0 -206000.0 -1.03 693960.0 -211444.333333333 -1.16406447486684 721770.0 -137404.193548387 -0.819875149725805 -1.8922 -0.9861 2072752 Maybridge1_006366 COc1ccc2-c3nc(/N=C/N(C)C)sc3CCc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J09 compound treatment 824750.0 -74300.0 -0.42 795960.0 -147000.0 -0.74 681220.0 -224184.333333333 -1.23420199605746 797180.0 -61994.193548387 -0.369912281459702 -1.3826 -0.8957 2072753 Maybridge1_006367 COC(=O)CSc1ncccc1C(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J10 compound treatment 777870.0 -121000.0 -0.69 735470.0 -208000.0 -1.04 709510.0 -195894.333333333 -1.07845706085474 741450.0 -117724.193548387 -0.702446834549079 -1.7562 -0.9793 1149514 Maybridge1_006368 O=C1CCCc2c1c3ccccc3n2Cc4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J11 compound treatment 747680.0 -151000.0 -0.86 726810.0 -216000.0 -1.08 753600.0 -151804.333333333 -0.835728386655796 579390.0 -279784.193548387 -1.66944036897693 -2.2262 -0.9576 2072754 Maybridge1_006369 Brc1ccc2cc[nH]c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J12 compound treatment 727250.0 -172000.0 -0.98 989320.0 46100.0 0.23 657610.0 -247794.333333333 -1.3641821275575 649360.0 -209814.193548387 -1.25193736019058 -1.6835 -0.7986 1458567 Maybridge1_006370 OCc1cn(Cc2ccccc2)c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J13 compound treatment 1045600.0 147000.0 0.84 811320.0 -132000.0 -0.66 814120.0 -91284.333333333 -0.50254763450066 1063770.0 204595.806451613 1.22079983962583 0.4478 0.2639 2072755 Maybridge1_006371 Cc1cc(c[nH]c1=O)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J14 compound treatment 815760.0 -83300.0 -0.48 819490.0 -124000.0 -0.62 938310.0 32905.666666667 0.181155564609489 841530.0 -17644.193548387 -0.105280890296705 -0.5094 -0.6302 1013983 Maybridge1_006372 CC1=NN(C(=O)C1)c2cccc(c2)S(=O)(=O)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J15 compound treatment 860100.0 -38900.0 -0.22 849500.0 -93800.0 -0.47 798840.0 -106564.333333333 -0.586668617529915 775430.0 -83744.193548387 -0.499692050519346 -0.8889 -0.9567 2072756 Maybridge1_006373 COC(=O)Cc1cc(OC)c(OC)cc1C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J16 compound treatment 808640.0 -90400.0 -0.52 874200.0 -69100.0 -0.35 851300.0 -54104.333333333 -0.297860582862724 794270.0 -64904.193548387 -0.387275919526992 -0.7735 -0.9786 1300508 Maybridge1_006374 Cc1c(O)ccc2C(=O)CC(C)(C)Oc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J17 compound treatment 812210.0 -86800.0 -0.5 820480.0 -123000.0 -0.61 853170.0 -52234.333333333 -0.287565671981526 864560.0 5385.80645161297 0.0321364927581733 -0.6828 -0.8121 2072757 Maybridge1_006375 OC(=O)c1ccccc1Sc2c(cc(cc2[N+](=O)[O-])[N+](=O)[O-])C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J18 compound treatment 734650.0 -164000.0 -0.94 689680.0 -254000.0 -1.27 831620.0 -73784.333333333 -0.406204885612444 670500.0 -188674.193548387 -1.12579739155054 -1.8697 -0.944 2072758 Maybridge1_006376 Cn1c(Sc2ncccc2[N+](=O)[O-])nnc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J19 compound treatment 853890.0 -45100.0 -0.26 818400.0 -125000.0 -0.62 783360.0 -122044.333333333 -0.671890660546463 803010.0 -56164.193548387 -0.335125336465784 -0.9447 -0.9353 1313637 Maybridge1_006377 S=C(NCc1ccco1)Nc2ccc3[nH]ccc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J20 compound treatment 873830.0 -25200.0 -0.14 846340.0 -96900.0 -0.48 821400.0 -84004.333333333 -0.462469050963162 840250.0 -18924.193548387 -0.112918504291939 -0.6021 -0.8669 1593978 Maybridge1_006378 COc1ccccc1C2CCN(CC2)C(=S)Nc3ccc(Br)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J21 compound treatment 818950.0 -80100.0 -0.46 849130.0 -94100.0 -0.47 783970.0 -121434.333333333 -0.668532427585216 729660.0 -129514.193548387 -0.772796419708306 -1.1848 -0.9755 2072759 Maybridge1_006379 CC(C)(C)c1ccc(cc1)c2nnc(o2)c3ccc(cc3)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J22 compound treatment 724110.0 -175000.0 -1.0 661600.0 -282000.0 -1.41 590650.0 -314754.333333333 -1.7328170113035 546560.0 -312614.193548387 -1.86533323418282 -3.0031 -0.9761 2072760 Maybridge1_006380 COc1cc(CC/C(=N/O)/C)ccc1OCc2ccc(Cl)c(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J23 mock treatment 881690.0 -17300.0 -0.1 862460.0 -80800.0 -0.4 835950.0 -69454.333333333 -0.382366936887531 798740.0 -60434.193548387 -0.36060393940301 -0.6231 -0.9295 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 J24 mock treatment 853350.0 -45700.0 -0.26 1070920.0 128000.0 0.64 1090130.0 184725.666666667 1.01697020096429 832800.0 -26374.193548387 -0.157371804498575 0.6186 0.4993 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K01 compound treatment 792360.0 -107000.0 -0.61 841080.0 -102000.0 -0.51 760020.0 -145384.333333333 -0.800384361063661 1029650.0 170475.806451613 1.01720969156537 -0.4518 -0.2974 1921895 Maybridge1_006381 NC(=S)NNC(=O)C1(CC2CC3CC(C2)C1)C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K02 compound treatment 827260.0 -71800.0 -0.41 766690.0 -177000.0 -0.88 748810.0 -156594.333333333 -0.862098773351484 805860.0 -53314.193548387 -0.31811971155452 -1.2367 -0.9237 2072761 Maybridge1_006382 CC(C)(C)c1cc([nH]n1)C(=O)NNS(=O)(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K03 compound treatment 900920.0 1890.0 0.01 856170.0 -87100.0 -0.44 794970.0 -110434.333333333 -0.607974128284052 865810.0 6635.80645161297 0.0395951001753942 -0.4966 -0.663 1272169 Maybridge1_006383 Cc1onc(c1NC(=O)SCc2c(Cl)cccc2Cl)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K04 compound treatment 845830.0 -53200.0 -0.3 893670.0 -49600.0 -0.25 736650.0 -168754.333333333 -0.929043220578954 788330.0 -70844.193548387 -0.422719221973626 -0.9519 -0.8705 2072762 Maybridge1_006384 CSc1nc(c2cccs2)c(C#N)c(=O)n1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K05 compound treatment 763380.0 -136000.0 -0.77 719590.0 -224000.0 -1.12 714880.0 -190524.333333333 -1.0488936001959 721760.0 -137414.193548387 -0.819934818585143 -1.8812 -0.9881 2072763 Maybridge1_006385 CC(C)(C)c1ccc(cc1)N2C(=N)SCC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K06 compound treatment 932260.0 33200.0 0.19 787880.0 -155000.0 -0.78 737130.0 -168274.333333333 -0.926400676609448 845320.0 -13854.193548387 -0.0826663926076908 -0.7982 -0.6506 2072764 Maybridge1_006386 CCC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K07 compound treatment 788320.0 -111000.0 -0.63 746240.0 -197000.0 -0.99 700260.0 -205144.333333333 -1.12938108526708 796180.0 -62994.193548387 -0.375879167393479 -1.5616 -0.9352 2072765 Maybridge1_006387 CSc1nc(N)nc(n1)c2cc(Cl)cc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K08 compound treatment 815200.0 -83800.0 -0.48 841360.0 -102000.0 -0.51 797170.0 -108234.333333333 -0.595862468423819 779160.0 -80014.193548387 -0.477435565986359 -1.0309 -0.9957 2072766 Maybridge1_006388 OC(=O)c1cnn2c1[nH]c(=O)c3ccccc32 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K09 compound treatment 834410.0 -64600.0 -0.37 898570.0 -44700.0 -0.22 763710.0 -141694.333333333 -0.780069804298089 761250.0 -97924.193548387 -0.5843024930603 -0.9785 -0.918 1238111 Maybridge1_006389 CC(C)(C)c1nc(N)nc(O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K10 compound treatment 670850.0 -228000.0 -1.3 719150.0 -224000.0 -1.12 664960.0 -240444.333333333 -1.32371817302445 586080.0 -273094.193548387 -1.62952190207997 -2.6888 -0.9909 1653742 Maybridge1_006390 CCOC(=O)c1ccc2nc(NC(=O)c3ccc(F)c(Cl)c3)sc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K11 compound treatment 836760.0 -62300.0 -0.36 833250.0 -110000.0 -0.55 739140.0 -166264.333333333 -0.915335023737145 782630.0 -76544.193548387 -0.456730471796153 -1.139 -0.9376 1025079 Maybridge1_006391 COC(=O)c1ccc(nc1)C(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K12 compound treatment 797380.0 -102000.0 -0.58 846560.0 -96700.0 -0.48 1099880.0 194475.666666667 1.07064687534487 794400.0 -64774.193548387 -0.386500224355601 -0.1901 -0.1391 1391060 Maybridge1_006392 CCOC(=O)C1(O)C(=O)Nc2cc(OC)cc(OC)c21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K13 compound treatment 736990.0 -162000.0 -0.93 1054960.0 112000.0 0.56 830330.0 -75074.333333333 -0.41330672253049 721250.0 -137924.193548387 -0.822977930411369 -0.8016 -0.5644 2072767 Maybridge1_006393 Clc1ccc(CCN2C(=O)CNC2=S)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K14 compound treatment 894120.0 -4910.0 -0.03 830140.0 -113000.0 -0.57 807870.0 -97534.333333333 -0.536955759103595 830130.0 -29044.193548387 -0.173303389941759 -0.6521 -0.8155 2072768 Maybridge1_006394 CCOC(=O)COc1cccc(c1)C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K15 compound treatment 790180.0 -109000.0 -0.62 828900.0 -114000.0 -0.57 750880.0 -154524.333333333 -0.850702802482993 767420.0 -91754.193548387 -0.547486806848897 -1.296 -0.9833 2072769 Maybridge1_006395 NC(=S)c1ccc(cc1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K16 compound treatment 826180.0 -72900.0 -0.42 827450.0 -116000.0 -0.58 763450.0 -141954.333333333 -0.781501182281571 781360.0 -77814.193548387 -0.46430841693205 -1.1206 -0.9699 2072770 Maybridge1_006396 OC(=O)c1cc(ccc1F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K17 compound treatment 753020.0 -146000.0 -0.83 868480.0 -74800.0 -0.37 751900.0 -153504.333333333 -0.845087396547794 793020.0 -66154.193548387 -0.394734526944213 -1.224 -0.9372 1469361 Maybridge1_006397 O=C1CNC(=S)N1Cc2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K18 compound treatment 751890.0 -147000.0 -0.84 719260.0 -224000.0 -1.12 646200.0 -259204.333333333 -1.42699759983262 713920.0 -145254.193548387 -0.866715204305952 -2.1273 -0.9762 2072771 Maybridge1_006398 CCCCCCCC(=O)Nc1nnc(Sc2ccnc3cc(Cl)ccc23)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K19 compound treatment 850210.0 -48800.0 -0.28 806510.0 -137000.0 -0.68 745000.0 -160404.333333333 -0.883073966109433 816240.0 -42934.193548387 -0.256183435561918 -1.0511 -0.8912 2072772 Maybridge1_006399 FC(F)(F)c1ccncc1C(=O)Nc2ccc(Cl)cc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K20 compound treatment 687840.0 -211000.0 -1.21 698010.0 -245000.0 -1.23 694030.0 -211374.333333333 -1.16367910387128 644610.0 -214564.193548387 -1.28028006837602 -2.4385 -0.9994 1614406 Maybridge1_006400 Cc1c(O)c(ccc1OCc2ccc(Cl)c(Cl)c2)c3cc[nH]n3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K21 compound treatment 784600.0 -114000.0 -0.65 719850.0 -223000.0 -1.12 717360.0 -188044.333333333 -1.03524045635345 683790.0 -175384.193548387 -1.04649747749064 -1.9264 -0.9827 2072773 Maybridge1_006401 COC(=O)c1cc(I)c(OC(=O)C)c(I)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K22 compound treatment 813330.0 -85700.0 -0.49 857560.0 -85700.0 -0.43 815480.0 -89924.333333333 -0.495060426587062 777510.0 -81664.193548387 -0.48728092777709 -0.9503 -0.9984 2072774 Maybridge1_006402 C1CCN(C1)C/23OC4=C(CCCC4)C(C3CCC\C2=C/c5ccccc5)c6ccccc6 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K23 mock treatment 897690.0 -1340.0 -0.01 882910.0 -60400.0 -0.3 845090.0 -60314.333333333 -0.332048495468199 831420.0 -27754.193548387 -0.165606107087187 -0.4036 -0.8436 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 K24 mock treatment 895050.0 -3980.0 -0.02 924510.0 -18800.0 -0.09 853630.0 -51774.333333333 -0.28503323401075 877760.0 18585.806451613 0.110899387084026 -0.1453 -0.4532 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L01 compound treatment 1103160.0 204000.0 1.17 760710.0 -183000.0 -0.91 1072900.0 167495.666666667 0.922113883058921 992660.0 133485.806451613 0.796494580874971 0.9858 0.514 2072775 Maybridge1_006403 COc1cccc(CNC(C)C(=O)O)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L02 compound treatment 824320.0 -74700.0 -0.43 830720.0 -113000.0 -0.56 735300.0 -170104.333333333 -0.936475375493188 816760.0 -42414.193548387 -0.253080654876354 -1.0896 -0.908 1528089 Maybridge1_006404 CCOC(=O)c1c(C)n(c2ccccc2)c3ccc(OC)cc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L03 compound treatment 879960.0 -19100.0 -0.11 766880.0 -176000.0 -0.88 747320.0 -158084.333333333 -0.870301670256824 834080.0 -25094.193548387 -0.149734190503341 -1.0056 -0.8026 2072776 Maybridge1_006405 OC(=O)C(Cc1ccccc1)NCc2ccccc2O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L04 compound treatment 837970.0 -61100.0 -0.35 766190.0 -177000.0 -0.89 737640.0 -167764.333333333 -0.923592973641849 761040.0 -98134.193548387 -0.585555539106393 -1.3718 -0.9462 1684989 Maybridge1_006406 O=C(NCCc1ccccc1)c2ccco2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L05 compound treatment 771480.0 -128000.0 -0.73 708350.0 -235000.0 -1.17 634430.0 -270974.333333333 -1.49179498008487 799530.0 -59644.193548387 -0.355890099515327 -1.8756 -0.9084 1054407 Maybridge1_006407 O=C(Nc1ccccc1)C(C(=O)Nc2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L06 compound treatment 768380.0 -131000.0 -0.75 726670.0 -217000.0 -1.08 724880.0 -180524.333333333 -0.9938406008312 724490.0 -134684.193548387 -0.803645219985932 -1.8136 -0.9888 2072777 Maybridge1_006408 [O-][N+](=O)c1cccc2[nH]ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L07 compound treatment 795620.0 -103000.0 -0.59 729790.0 -213000.0 -1.07 722420.0 -182984.333333333 -1.00738363867492 835140.0 -24034.193548387 -0.143409291413538 -1.4046 -0.8841 2072778 Maybridge1_006409 CCCCCCCCCCCC1SC[C@H](N1C(=O)C)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L08 compound treatment 867360.0 -31700.0 -0.18 843390.0 -99900.0 -0.5 786250.0 -119154.333333333 -0.655980343730066 887130.0 27955.806451613 0.166809108283514 -0.5848 -0.6796 2072779 Maybridge1_006410 C[C@@H](O[C@@H]1[C@@H](NC(=O)C)[C@@H](OCc2ccccc2)O[C@@H]3COC(O[C@@H]13)c4ccccc4)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L09 compound treatment 916880.0 17800.0 0.1 1089710.0 146000.0 0.73 906820.0 1415.66666666698 0.00779366961006372 835780.0 -23394.193548387 -0.139590484415921 0.3513 0.4668 2072780 Maybridge1_006411 OC(=O)c1[nH]c2ccc(cc2c1c3ccccc3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L10 compound treatment 849470.0 -49600.0 -0.28 784410.0 -159000.0 -0.79 749550.0 -155854.333333333 -0.858024851398497 840640.0 -18534.193548387 -0.110591418777766 -1.0231 -0.8468 1290636 Maybridge1_006412 CC1(C)CC(=O)c2ccc(OCC(=O)Nc3ccccc3)cc2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L11 compound treatment 761410.0 -138000.0 -0.79 675880.0 -267000.0 -1.34 633570.0 -271834.333333333 -1.49652953803023 735200.0 -123974.193548387 -0.739739871635183 -2.1799 -0.9566 2072781 Maybridge1_006413 Cc1cc(OC(=O)c2c(C)onc2c3c(Cl)cccc3Cl)n(n1)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L12 compound treatment 821350.0 -77700.0 -0.44 855010.0 -88300.0 -0.44 829920.0 -75484.333333333 -0.415563895504442 759910.0 -99264.193548387 -0.592298120211561 -0.9465 -0.9894 1688823 Maybridge1_006414 OC(=O)Cc1csc(n1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L13 compound treatment 736050.0 -163000.0 -0.93 779330.0 -164000.0 -0.82 739480.0 -165924.333333333 -0.913463221758745 817310.0 -41864.193548387 -0.249798867612777 -1.4571 -0.9336 1037728 Maybridge1_006415 Brc1ccc2CCc3cccc1c32 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L14 compound treatment 837220.0 -61800.0 -0.35 913450.0 -29800.0 -0.15 820610.0 -84794.333333333 -0.466818237912973 787520.0 -71654.193548387 -0.427552399579985 -0.6983 -0.9436 1017937 Maybridge1_006416 CCOC(=O)Cc1ccc(cc1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L15 compound treatment 540050.0 -359000.0 -2.05 643040.0 -300000.0 -1.5 549440.0 -355964.333333333 -1.95969042168541 490260.0 -368914.193548387 -2.20126891225445 -3.8566 -0.991 2072782 Maybridge1_006417 C/C(=N\Nc1ccccc1)/c2cc3cc(Br)ccc3oc2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L16 compound treatment 820220.0 -78800.0 -0.45 813860.0 -129000.0 -0.65 815100.0 -90304.333333333 -0.49715244056292 746660.0 -112514.193548387 -0.671359358834102 -1.133 -0.9863 1595740 Maybridge1_006418 CCCCc1ccc(NC(=S)N2CCC(CC2)C(=O)OCC)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L17 compound treatment 751950.0 -147000.0 -0.84 727910.0 -215000.0 -1.08 696480.0 -208924.333333333 -1.15019111902693 757280.0 -101894.193548387 -0.607991030217393 -1.8377 -0.9742 1944028 Maybridge1_006419 Sc1nnc(c2ccccc2)n1Cc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L18 compound treatment 821180.0 -77900.0 -0.44 919380.0 -23900.0 -0.12 873560.0 -31844.333333333 -0.175312606276912 831200.0 -27974.193548387 -0.166918821992618 -0.4532 -0.8711 2072783 Maybridge1_006420 Cc1nc(cn1CC/C(=N/O)/N)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L19 compound treatment 893960.0 -5070.0 -0.03 819570.0 -124000.0 -0.62 843610.0 -61794.333333333 -0.340196339374174 844520.0 -14654.193548387 -0.0874399013547122 -0.5376 -0.7551 2072784 Maybridge1_006421 CCC(=O)c1cc(OC)c(OC)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L20 compound treatment 795610.0 -103000.0 -0.59 1057280.0 114000.0 0.57 935540.0 30135.666666667 0.165905883785468 759250.0 -99924.193548387 -0.596236264927853 -0.2254 -0.2192 1447787 Maybridge1_006422 CCOc1ccc(NC(=S)N2CCC(CC2)c3ccccc3OC)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L21 compound treatment 801510.0 -97500.0 -0.56 791410.0 -152000.0 -0.76 767520.0 -137884.333333333 -0.75909461154014 806470.0 -52704.193548387 -0.314479911134916 -1.1951 -0.9561 1007880 Maybridge1_006423 COc1ccc(NC(=O)C)c(c1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L22 compound treatment 793020.0 -106000.0 -0.61 774620.0 -169000.0 -0.84 764290.0 -141114.333333333 -0.776876730334936 799360.0 -59814.193548387 -0.356904470124069 -1.2914 -0.9601 2072785 Maybridge1_006424 COS(=O)(=O)c1ccc2C(=O)CC(C)(C)Oc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L23 mock treatment 835290.0 -63700.0 -0.36 880020.0 -63200.0 -0.32 826240.0 -79164.333333333 -0.43582339927065 798840.0 -60334.193548387 -0.360007250809633 -0.7381 -0.9933 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 L24 mock treatment 879450.0 -19600.0 -0.11 898350.0 -44900.0 -0.22 840360.0 -65044.333333333 -0.3580885641677 1010100.0 150925.806451613 0.900557071560037 0.103 0.1029 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M01 compound treatment 986920.0 87900.0 0.5 1014240.0 71000.0 0.35 952170.0 46765.666666667 0.257459021728956 1051680.0 192505.806451613 1.14866018868647 1.1316 0.852 2072786 Maybridge1_006425 CCOC(=O)CN/C(=N\O)/c1c(Cl)cccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M02 compound treatment 875150.0 -23900.0 -0.14 727300.0 -216000.0 -1.08 702300.0 -203104.333333333 -1.11815027339668 1014420.0 155245.806451613 0.926334018793953 -0.7042 -0.388 2072787 Maybridge1_006426 FC(F)(F)c1ccc(=O)[nH]c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M03 compound treatment 772760.0 -126000.0 -0.72 715040.0 -228000.0 -1.14 702360.0 -203044.333333333 -1.11781995540049 747360.0 -111814.193548387 -0.667182538680458 -1.8239 -0.9724 2072788 Maybridge1_006427 N/C(=N\O)/c1ccc(cc1)C2SCCS2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M04 compound treatment 862990.0 -36000.0 -0.21 809880.0 -133000.0 -0.67 744490.0 -160914.333333333 -0.885881669077033 855320.0 -3854.19354838703 -0.0229975332699236 -0.8909 -0.7897 2072789 Maybridge1_006428 Oc1nnc(o1)C2c3ccccc3Oc4ccccc24 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M05 compound treatment 898670.0 -363.0 0.0 794400.0 -149000.0 -0.74 768040.0 -137364.333333333 -0.756231855573176 905760.0 46585.806451613 0.277972193229774 -0.6124 -0.5583 2072790 Maybridge1_006429 CSc1nc(N)nc(n1)c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M06 compound treatment 832650.0 -66400.0 -0.38 874800.0 -68500.0 -0.34 862730.0 -42674.333333333 -0.234935004588877 818080.0 -41094.193548387 -0.245204365443769 -0.6009 -0.9795 2072791 Maybridge1_006430 CCC(=O)Nc1cc(F)ccc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M07 compound treatment 837030.0 -62000.0 -0.35 767140.0 -176000.0 -0.88 748990.0 -156414.333333333 -0.86110781936292 758880.0 -100294.193548387 -0.598444012723351 -1.3473 -0.9524 2072792 Maybridge1_006431 CCSc1nc(N)nc(n1)C(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M08 compound treatment 741080.0 -158000.0 -0.9 730900.0 -212000.0 -1.06 657160.0 -248244.333333333 -1.36665951252892 701500.0 -157674.193548387 -0.940823927603459 -2.136 -0.9857 2072793 Maybridge1_006432 COc1ccc2nnc(c3ccc(cc3)C(F)(F)F)n2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M09 compound treatment 708120.0 -191000.0 -1.09 675590.0 -268000.0 -1.34 650630.0 -254774.333333333 -1.40260912111406 714500.0 -144674.193548387 -0.863254410464361 -2.3476 -0.9838 1579175 Maybridge1_006433 CSc1nc(N)nc(n1)C2(CC3CC4CC(C3)C2)C4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M10 compound treatment 771200.0 -128000.0 -0.73 795290.0 -148000.0 -0.74 743440.0 -161964.333333333 -0.891662234010326 679780.0 -179394.193548387 -1.07042469008509 -1.7162 -0.9873 1940042 Maybridge1_006434 CCOC(=O)C1=C(C)Nc2ccccc2S1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M11 compound treatment 715790.0 -183000.0 -1.05 846190.0 -97100.0 -0.49 772380.0 -133024.333333333 -0.732338853848898 753820.0 -105354.193548387 -0.628636455548261 -1.4466 -0.9617 1295563 Maybridge1_006435 CC(C)(C)C(=O)OCc1noc(n1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M12 compound treatment 32060.0 -867000.0 -4.95 31790.0 -911000.0 -4.56 29390.0 -876014.333333333 -4.82272165364638 35930.0 -823244.193548387 -4.91220419854723 -9.6231 -0.9995 2072794 Maybridge1_006436 COc1ccc(OC)c([N+](=O)[O-])c1/C=C/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M13 compound treatment 811360.0 -87700.0 -0.5 809330.0 -134000.0 -0.67 829920.0 -75484.333333333 -0.415563895504442 817920.0 -41254.193548387 -0.246159067193173 -0.9162 -0.9486 1533787 Maybridge1_006437 O=C1CNC(=S)N1CCc2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M14 compound treatment 785540.0 -113000.0 -0.65 853310.0 -90000.0 -0.45 827680.0 -77724.333333333 -0.427895767362134 800330.0 -58844.193548387 -0.351116590768305 -0.9386 -0.9738 2072795 Maybridge1_006438 FC(F)(F)c1ccc2[nH]nnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M15 compound treatment 790790.0 -108000.0 -0.62 804260.0 -139000.0 -0.7 725850.0 -179554.333333333 -0.988500459892825 756840.0 -102334.193548387 -0.610616460028255 -1.4563 -0.9784 1266151 Maybridge1_006439 O=C1CNC(=S)N1CCOc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M16 compound treatment 870510.0 -28500.0 -0.16 1077940.0 135000.0 0.67 890450.0 -14954.333333333 -0.0823280903499422 828610.0 -30564.193548387 -0.1823730565611 0.123 0.1705 1729344 Maybridge1_006440 COc1ccc(OC)c2[nH]ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M17 compound treatment 709450.0 -190000.0 -1.08 714400.0 -229000.0 -1.14 714400.0 -191004.333333333 -1.0515361441654 691110.0 -168064.193548387 -1.0028198724554 -2.141 -0.9988 2072796 Maybridge1_006441 CSC1=N/C(=C\c2ccc(Cl)cc2)/C(=O)N1Cc3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M18 compound treatment 705920.0 -193000.0 -1.1 669830.0 -273000.0 -1.37 644110.0 -261294.333333333 -1.43850367669984 684490.0 -174684.193548387 -1.042320657337 -2.4758 -0.9909 2072797 Maybridge1_006442 COc1ccc(cc1)/C(=N/NC2=NCCCN2)/C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M19 compound treatment 764960.0 -134000.0 -0.77 870340.0 -72900.0 -0.36 698830.0 -206574.333333333 -1.13725366417623 765240.0 -93934.193548387 -0.560494618184531 -1.4142 -0.927 2072798 Maybridge1_006443 CSc1nc(nc(N)c1C#N)c2cccnc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M20 compound treatment 34900.0 -864000.0 -4.94 40160.0 -903000.0 -4.52 34420.0 -870984.333333333 -4.79502999496594 38560.0 -820614.193548387 -4.8965112885414 -9.5724 -0.9994 1006201 Maybridge1_006444 CC(=O)OC(OC(=O)C)c1ccc(o1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M21 compound treatment 836980.0 -62100.0 -0.35 830400.0 -113000.0 -0.56 758240.0 -147164.333333333 -0.810183794950577 766740.0 -92434.193548387 -0.551544289283866 -1.1403 -0.9621 2072799 Maybridge1_006445 FC(F)(F)c1ccccc1NC(=O)c2cc(Cl)cc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M22 compound treatment 877460.0 -21600.0 -0.12 981330.0 38100.0 0.19 776640.0 -128764.333333333 -0.708886276119538 873370.0 14195.806451613 0.0847047578347462 -0.2785 -0.3718 1540353 Maybridge1_006446 CCCCn1c(=O)c2c(O)cc(=O)oc2c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M23 mock treatment 902520.0 3490.0 0.02 825810.0 -117000.0 -0.59 794020.0 -111384.333333333 -0.613204163223698 808020.0 -51154.193548387 -0.305231237937562 -0.743 -0.8232 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 M24 mock treatment 921210.0 22200.0 0.13 762170.0 -181000.0 -0.91 760590.0 -144814.333333333 -0.797246340099874 751650.0 -107524.193548387 -0.641584598024556 -1.1089 -0.808 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N01 compound treatment 815960.0 -83100.0 -0.47 844860.0 -98400.0 -0.49 798150.0 -107254.333333333 -0.590467274486079 836060.0 -23114.193548387 -0.137919756354463 -0.8476 -0.9275 2072800 Maybridge1_006447 COc1cc(Cl)cc(CNC(C)C(=O)O)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N02 compound treatment 825920.0 -73100.0 -0.42 700340.0 -243000.0 -1.22 687130.0 -218274.333333333 -1.20166567343292 729130.0 -130044.193548387 -0.775958869253208 -1.8051 -0.9389 1618130 Maybridge1_006448 CCc1c(C(=O)OC)c2cc(O)ccc2n1Cc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N03 compound treatment 902520.0 3490.0 0.02 742240.0 -201000.0 -1.01 738810.0 -166594.333333333 -0.91715177271618 851140.0 -8034.19354838703 -0.0479391164731103 -0.9753 -0.7161 2072801 Maybridge1_006449 CC(=CC(NCc1ccccc1O)C(=O)O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N04 compound treatment 834830.0 -64200.0 -0.37 989450.0 46200.0 0.23 799360.0 -106044.333333333 -0.58380586156295 790590.0 -68584.193548387 -0.409234059763291 -0.5644 -0.6764 2072802 Maybridge1_006450 Cc1cc(ccc1n2cccc2)c3nnc(o3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N05 compound treatment 822410.0 -76600.0 -0.44 821600.0 -122000.0 -0.61 768800.0 -136604.333333333 -0.752047827621459 876840.0 17665.806451613 0.105409852024951 -0.8464 -0.7933 1291953 Maybridge1_006451 Cc1cc2CCCn3c(=O)cc(O)c(c1)c23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N06 compound treatment 905210.0 6180.0 0.04 866330.0 -76900.0 -0.38 807720.0 -97684.333333333 -0.537781554094065 849290.0 -9884.19354838703 -0.0589778554505972 -0.4731 -0.7117 1162160 Maybridge1_006452 Cc1cc(O)c2c3[nH]ncc3ccc2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N07 compound treatment 902460.0 3430.0 0.02 970210.0 26900.0 0.13 860720.0 -44684.333333333 -0.246000657461181 856910.0 -2264.19354838703 -0.0135101846352186 -0.0526 -0.1868 1006493 Maybridge1_006453 CCCCC(C(=O)O)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N08 compound treatment 815720.0 -83300.0 -0.48 851610.0 -91700.0 -0.46 744490.0 -160914.333333333 -0.885881669077033 785440.0 -73734.193548387 -0.439963522322241 -1.1301 -0.95 2072803 Maybridge1_006454 CC(=O)N[C@@H]1[C@@H](O)[C@@H]2OC(OC[C@H]2O[C@@H]1OCc3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N09 compound treatment 762940.0 -136000.0 -0.78 694480.0 -249000.0 -1.24 655050.0 -250354.333333333 -1.37827569539487 709440.0 -149734.193548387 -0.893446853289272 -2.1467 -0.9747 2072804 Maybridge1_006455 CC1=N/C(=C\c2ccccc2)/C(=O)O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N10 compound treatment 837690.0 -61300.0 -0.35 826470.0 -117000.0 -0.58 723440.0 -181964.333333333 -1.00176823273972 796130.0 -63044.193548387 -0.376177511690168 -1.1563 -0.9115 1355251 Maybridge1_006456 OC(=O)C(CC(=O)c1cccs1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N11 compound treatment 768010.0 -131000.0 -0.75 836640.0 -107000.0 -0.53 811200.0 -94204.333333333 -0.518623110315151 842880.0 -16294.193548387 -0.097225594286106 -0.9488 -0.8953 1027704 Maybridge1_006457 OC(=O)c1ccccc1Oc2cccc(c2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N12 compound treatment 780590.0 -118000.0 -0.68 708120.0 -235000.0 -1.18 688550.0 -216854.333333333 -1.19384814752314 762620.0 -96554.193548387 -0.576127859331026 -1.8113 -0.9549 2072805 Maybridge1_006458 FC(F)(F)c1ccc2[nH]c(S)nc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N13 compound treatment 912700.0 13700.0 0.08 937130.0 -6130.0 -0.03 857920.0 -47484.333333333 -0.261415497283296 840210.0 -18964.193548387 -0.11315717972929 -0.1636 -0.5509 2072806 Maybridge1_006459 Cc1cc(ccc1[N+](=O)[O-])C(=O)NNC(=O)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N14 compound treatment 791070.0 -108000.0 -0.62 861520.0 -81700.0 -0.41 808840.0 -96564.333333333 -0.531615618165219 790990.0 -68184.193548387 -0.40684730538978 -0.982 -0.9842 1003119 Maybridge1_006460 O=C(CC(=O)Nc1ccccc1)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N15 compound treatment 871840.0 -27200.0 -0.16 801730.0 -142000.0 -0.71 819380.0 -86024.333333333 -0.473589756834831 825860.0 -33314.193548387 -0.198781992878986 -0.7678 -0.8644 1913136 Maybridge1_006461 OC(=O)c1ccccc1N/C=C/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N16 compound treatment 827200.0 -71800.0 -0.41 803390.0 -140000.0 -0.7 716000.0 -189404.333333333 -1.04272766426705 766450.0 -92724.193548387 -0.553274686204661 -1.353 -0.9447 2072807 Maybridge1_006462 CCOC(=O)C1CCN(CC1)C(=S)Nc2ccccc2C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N17 compound treatment 733570.0 -165000.0 -0.95 790740.0 -153000.0 -0.76 695770.0 -209634.333333333 -1.15409988198183 703280.0 -155894.193548387 -0.930202870641336 -1.8962 -0.9895 1208730 Maybridge1_006463 CCc1cc2c(cc1C(=O)CSc3ncccc3C(=O)O)C(C)(C)CCC2(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N18 compound treatment 799850.0 -99200.0 -0.57 769460.0 -174000.0 -0.87 739870.0 -165534.333333333 -0.911316154783522 763750.0 -95424.193548387 -0.569385278225858 -1.4583 -0.9762 2072808 Maybridge1_006464 Cc1c(OCc2cccc(OC(F)(F)F)c2)ccc3C(=O)CC(C)(C)Oc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N19 compound treatment 827840.0 -71200.0 -0.41 897170.0 -46100.0 -0.23 880170.0 -25234.333333333 -0.138922573696849 754980.0 -104194.193548387 -0.62171486786508 -0.6989 -0.8845 1013422 Maybridge1_006465 CC(=O)OC(C(=O)O)c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N20 compound treatment 814970.0 -84100.0 -0.48 709220.0 -234000.0 -1.17 735680.0 -169724.333333333 -0.934383361517329 773600.0 -85574.193548387 -0.510611451778157 -1.5479 -0.936 2072809 Maybridge1_006466 COc1ccccc1C2CCN(CC2)c3ncccc3[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N21 compound treatment 188880.0 -710000.0 -4.06 124060.0 -819000.0 -4.1 142820.0 -762584.333333333 -4.19825548185265 103280.0 -755894.193548387 -4.51033443090737 -8.4313 -0.9991 2072810 Maybridge1_006467 ClC1=C(Cl)C(=O)OC1c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N22 compound treatment 837880.0 -61200.0 -0.35 797920.0 -145000.0 -0.73 759370.0 -146034.333333333 -0.803962806022366 715480.0 -143694.193548387 -0.85740686224926 -1.3688 -0.9603 1057919 Maybridge1_006468 OC(=O)c1ccccc1C(=O)Nc2ccc(F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N23 mock treatment 832110.0 -66900.0 -0.38 1213760.0 270000.0 1.35 1138450.0 233045.666666667 1.2829862938945 828640.0 -30534.193548387 -0.182194049983087 1.0357 0.5417 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 N24 mock treatment 900690.0 1660.0 0.01 964160.0 20900.0 0.1 895410.0 -9994.33333333302 -0.0550218026650535 871280.0 12105.806451613 0.0722339662331529 0.0656 0.4727 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O01 compound treatment 801210.0 -97800.0 -0.56 740340.0 -203000.0 -1.01 764800.0 -140604.333333333 -0.774069027367337 878270.0 19095.806451613 0.113942498910252 -1.1169 -0.7989 1440413 Maybridge1_006469 COC(=O)c1c(NC(=O)NN2CCCCC2)onc1c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O02 compound treatment 935280.0 36200.0 0.21 987760.0 44500.0 0.22 831920.0 -73484.333333333 -0.404553295631503 1079230.0 220055.806451613 1.31304789616202 0.6691 0.4755 2072811 Maybridge1_006470 Brc1c[nH]nc1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O03 compound treatment 776700.0 -122000.0 -0.7 656350.0 -287000.0 -1.44 570410.0 -334994.333333333 -1.84424428201765 752160.0 -107014.193548387 -0.63854148619833 -2.3083 -0.9155 2072812 Maybridge1_006471 CN(C)C(=O)O/N=C(\N)/c1ccc(cc1)C2SCCS2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O04 compound treatment 841320.0 -57700.0 -0.33 778940.0 -164000.0 -0.82 833300.0 -72104.333333333 -0.396955981719175 974720.0 115545.806451613 0.689448647223017 -0.4295 -0.3608 1434269 Maybridge1_006472 NNC(=O)C1c2ccccc2Oc3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O05 compound treatment 782880.0 -116000.0 -0.66 779610.0 -164000.0 -0.82 781550.0 -123854.333333333 -0.681855253431473 801710.0 -57464.193548387 -0.342882288179694 -1.2534 -0.9634 1739883 Maybridge1_006473 COc1nc(N)nc(n1)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O06 compound treatment 813820.0 -85200.0 -0.49 771150.0 -172000.0 -0.86 809980.0 -95424.333333333 -0.525339576237644 779290.0 -79884.193548387 -0.476659870814968 -1.1748 -0.9653 2072813 Maybridge1_006474 CCC(=O)Nc1ccc(F)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O07 compound treatment 807290.0 -91700.0 -0.52 710210.0 -233000.0 -1.17 733600.0 -171804.333333333 -0.945834385385186 759000.0 -100174.193548387 -0.597727986411297 -1.6166 -0.9517 2072814 Maybridge1_006475 CSc1nc(N)nc(n1)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O08 compound treatment 785510.0 -114000.0 -0.65 784050.0 -159000.0 -0.8 812010.0 -93394.333333333 -0.514163817366611 834160.0 -25014.193548387 -0.149256839628639 -1.0541 -0.9102 1571659 Maybridge1_006476 Oc1ncnc2n(ncc12)c3ccc(F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O09 compound treatment 876410.0 -22600.0 -0.13 1032430.0 89200.0 0.45 875210.0 -30194.333333333 -0.166228861381738 842250.0 -16924.193548387 -0.100984732424385 0.0248 0.0492 1382127 Maybridge1_006477 Nc1nc(O)nc(n1)C2(CC3CC4CC(C3)C2)C4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O10 compound treatment 830320.0 -68700.0 -0.39 895760.0 -47500.0 -0.24 890400.0 -15004.333333333 -0.0826033553467657 800180.0 -58994.193548387 -0.352011623658372 -0.5324 -0.9113 1374339 Maybridge1_006478 Cc1cc2CCCn3c(=O)c(c(O)c(c1)c23)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O11 compound treatment 721120.0 -178000.0 -1.02 836600.0 -107000.0 -0.53 720490.0 -184914.333333333 -1.0180088675523 768240.0 -90934.193548387 -0.5425939603832 -1.5552 -0.9557 2072815 Maybridge1_006479 O=C1CNC(=S)N1Cc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O12 compound treatment 844290.0 -54700.0 -0.31 814240.0 -129000.0 -0.65 883770.0 -21634.333333333 -0.119103493925559 869140.0 9965.80645161297 0.0594648303348707 -0.5088 -0.6977 1003148 Maybridge1_006480 CC(=O)Nc1ccc(I)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O13 compound treatment 717940.0 -181000.0 -1.03 892420.0 -50800.0 -0.25 708920.0 -196484.333333333 -1.08170518781725 761500.0 -97674.193548387 -0.582810771576856 -1.4766 -0.908 1400940 Maybridge1_006481 O=C1CNC(=S)N1CCc2ccncc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O14 compound treatment 897860.0 -1170.0 -0.01 1169710.0 226000.0 1.13 953120.0 47715.666666667 0.262689056668602 941390.0 82215.806451613 0.490572339050239 0.9396 0.7446 2072816 Maybridge1_006482 O=c1[nH]c(=S)[nH]c(C2CCCCC2)c1C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O15 compound treatment 852770.0 -46300.0 -0.26 986030.0 42800.0 0.21 741320.0 -164084.333333333 -0.903333469875641 804960.0 -54214.193548387 -0.323489908894919 -0.6386 -0.6273 2072817 Maybridge1_006483 COc1nc(N)nc(SC)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O16 compound treatment 904230.0 5200.0 0.03 792020.0 -151000.0 -0.76 802370.0 -103034.333333333 -0.567234908754177 996000.0 136825.806451613 0.816423979893786 -0.2388 -0.1911 2072818 Maybridge1_006484 O=C(CC#N)NNC(=S)NC1CCCCCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O17 compound treatment 768160.0 -131000.0 -0.75 796660.0 -147000.0 -0.73 730780.0 -174624.333333333 -0.96135933120603 772360.0 -86814.193548387 -0.51801039033604 -1.4801 -0.9783 2072819 Maybridge1_006485 Fc1ccc(SC(=O)Nc2ccc(Cl)cc2)c(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O18 compound treatment 889520.0 -9510.0 -0.05 812220.0 -131000.0 -0.66 772370.0 -133034.333333333 -0.732393906848263 862910.0 3735.80645161297 0.0222911309674417 -0.7099 -0.721 1339858 Maybridge1_006486 Oc1nc(Nc2ccccc2)nc(Nc3ccccc3)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O19 compound treatment 862010.0 -37000.0 -0.21 828710.0 -115000.0 -0.57 862610.0 -42794.333333333 -0.235595640581254 813640.0 -45534.193548387 -0.271697338989737 -0.6459 -0.9113 2072820 Maybridge1_006487 N/C(=N\O)/c1cnccc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O20 compound treatment 950440.0 51400.0 0.29 1092230.0 149000.0 0.75 770490.0 -134914.333333333 -0.742743870728825 846090.0 -13084.193548387 -0.0780718904386827 0.109 0.0995 2072821 Maybridge1_006488 CS(=O)(=O)c1ccc(cc1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O21 compound treatment 835290.0 -63700.0 -0.36 979040.0 35800.0 0.18 749560.0 -155844.333333333 -0.857969798399132 810720.0 -48454.193548387 -0.289120645916365 -0.6661 -0.6714 2072822 Maybridge1_006489 FC(F)(F)c1cnc(c(Cl)c1)n2nc(oc2=O)c3ccc(Cl)c(Cl)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O22 compound treatment 788680.0 -110000.0 -0.63 963150.0 19900.0 0.1 752110.0 -153294.333333333 -0.843931283561135 776130.0 -83044.193548387 -0.495515230365702 -0.9352 -0.8004 1687593 Maybridge1_006490 CCCCc1ccc(NC(=O)CSc2nnc(N)s2)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O23 mock treatment 622970.0 -276000.0 -1.58 1106840.0 164000.0 0.82 1115470.0 210065.666666667 1.15647450135443 881120.0 21945.806451613 0.130948123821516 0.2643 0.1244 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 O24 mock treatment 885820.0 -13200.0 -0.08 1024830.0 81600.0 0.41 818100.0 -87304.333333333 -0.480636540753512 972640.0 113465.806451613 0.677037524480761 0.2644 0.2849 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P01 compound treatment 852830.0 -46200.0 -0.26 926720.0 -16500.0 -0.08 974010.0 68605.666666667 0.37769477234145 816090.0 -43084.193548387 -0.257078468451984 -0.113 -0.2116 2072823 Maybridge1_006491 CC(NCc1cc2ccccc2cc1O)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P02 compound treatment 805710.0 -93300.0 -0.53 970190.0 26900.0 0.13 940760.0 35355.666666667 0.194643549453839 1026580.0 167405.806451613 0.998891351748678 0.3976 0.3437 2072824 Maybridge1_006492 Cc1ccc2cc(F)ccc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P03 compound treatment 779400.0 -120000.0 -0.68 724890.0 -218000.0 -1.09 712120.0 -193284.333333333 -1.06408822802055 728650.0 -130524.193548387 -0.778822974501421 -1.8093 -0.9814 1443250 Maybridge1_006493 Oc1cc(=O)[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P04 compound treatment 893200.0 -5830.0 -0.03 796710.0 -147000.0 -0.73 791520.0 -113884.333333333 -0.626967413064871 1040750.0 181575.806451613 1.08344212543029 -0.1549 -0.1068 2072825 Maybridge1_006494 OC(=O)CNC(=O)CCCCC(=O)NCC(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P05 compound treatment 953450.0 54400.0 0.31 845960.0 -97300.0 -0.49 909930.0 4525.66666666698 0.0249151524124839 1150720.0 291545.806451613 1.73962057156772 0.7944 0.4333 2072826 Maybridge1_006495 OC(=O)[C@@H]1CSC(N1)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P06 compound treatment 854330.0 -44700.0 -0.26 1030030.0 86800.0 0.43 939170.0 33765.666666667 0.185890122554853 1026420.0 167245.806451613 0.997936649999273 0.6812 0.6012 2072827 Maybridge1_006496 CCCCCCCCCC(=O)Nc1nc-2c(Cc3ccccc23)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P07 compound treatment 810650.0 -88400.0 -0.5 814290.0 -129000.0 -0.65 776080.0 -129324.333333333 -0.711969244083961 809300.0 -49874.193548387 -0.297593623942328 -1.0798 -0.9595 1071563 Maybridge1_006497 Clc1ccc(OC(=O)CC(=O)Oc2ccc(Cl)cc2Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P08 compound treatment 975910.0 76900.0 0.44 894760.0 -48500.0 -0.24 808850.0 -96554.333333333 -0.531560565165855 905440.0 46265.806451613 0.276062789730966 -0.0295 -0.0377 2072828 Maybridge1_006498 COc1cccc(c1)C2CCCCN(C)C2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P09 compound treatment 757320.0 -142000.0 -0.81 924320.0 -18900.0 -0.09 756340.0 -149064.333333333 -0.820643864829869 769770.0 -89404.193548387 -0.533464624904522 -1.1292 -0.8865 2072829 Maybridge1_006499 Ic1ccc2[nH]ccc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P10 compound treatment 831250.0 -67800.0 -0.39 799300.0 -144000.0 -0.72 753120.0 -152284.333333333 -0.838370930625301 768980.0 -90194.193548387 -0.538178464792206 -1.2419 -0.9636 2072830 Maybridge1_006500 COc1ccc2nccc(C(=O)C3CC4CCN3CC4C=C)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P11 compound treatment 885250.0 -13800.0 -0.08 1024980.0 81700.0 0.41 882100.0 -23304.333333333 -0.128297344819463 913960.0 54785.806451613 0.326900657886743 0.2643 0.4853 2072831 Maybridge1_006501 CC(=O)c1c(O)c2ccccc2n(C)c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P12 compound treatment 760690.0 -138000.0 -0.79 775450.0 -168000.0 -0.84 802420.0 -102984.333333333 -0.566959643757354 740370.0 -118804.193548387 -0.708891071357558 -1.4527 -0.9901 2072832 Maybridge1_006502 CCC(=O)N/N=C(\C)/c1ccc(Oc2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P13 compound treatment 896990.0 -2040.0 -0.01 972050.0 28800.0 0.14 910750.0 5345.66666666698 0.0294294983603889 844570.0 -14604.193548387 -0.0871415570580233 0.0373 0.2178 2072833 Maybridge1_006503 [O-][N+](=O)c1cc(ccc1N2CCN(CC2)c3ccc(cc3[N+](=O)[O-])C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P14 compound treatment 606770.0 -292000.0 -1.67 658970.0 -284000.0 -1.42 594890.0 -310514.333333333 -1.70947453957287 672160.0 -187014.193548387 -1.11589236090047 -2.9584 -0.9874 1387909 Maybridge1_006504 Cc1ccc(C)c(COc2ccc(C)nc2N)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P15 compound treatment 837470.0 -61600.0 -0.35 1103220.0 160000.0 0.8 815890.0 -89514.333333333 -0.492803253613109 751360.0 -107814.193548387 -0.643314994945351 -0.3439 -0.2885 1089969 Maybridge1_006505 Oc1c(cnc2ccccc12)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P16 compound treatment 995960.0 96900.0 0.55 895290.0 -48000.0 -0.24 754900.0 -150504.333333333 -0.828571496738385 925480.0 66305.806451613 0.395639183843851 -0.0596 -0.0542 2072834 Maybridge1_006506 CCOC(=O)C1CCN(CC1)C(=S)Nc2ccccc2OC(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P17 compound treatment 829120.0 -69900.0 -0.4 1127080.0 184000.0 0.92 855150.0 -50254.333333333 -0.276665178107316 816770.0 -42404.193548387 -0.253020986017016 -0.0048 -0.0045 2072835 Maybridge1_006507 OC(=O)c1cccnc1SCC(=O)Nc2cc(Cl)cc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P18 compound treatment 893040.0 -5990.0 -0.03 1040130.0 96900.0 0.48 779290.0 -126114.333333333 -0.694297231287894 1061130.0 201955.806451613 1.20504726076066 0.4805 0.3262 2072836 Maybridge1_006508 Cn1c(Sc2ccc(cc2[N+](=O)[O-])C(F)(F)F)nnc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P19 compound treatment 833890.0 -65100.0 -0.37 1104090.0 161000.0 0.8 868230.0 -37174.333333333 -0.204655854938295 1012880.0 153705.806451613 0.917145014455937 0.5724 0.4431 2072837 Maybridge1_006509 CC(=O)OCCCCN1C(=O)c2ccccc2C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P20 compound treatment 877760.0 -21300.0 -0.12 1094950.0 152000.0 0.76 881940.0 -23464.333333333 -0.129178192809298 1025950.0 166775.806451613 0.995132213610398 0.7516 0.5947 2072838 Maybridge1_006510 COc1ccccc1C2CCN(CC2)c3ccc(cc3[N+](=O)[O-])C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P21 compound treatment 1085170.0 186000.0 1.06 1056070.0 113000.0 0.56 1013280.0 107875.666666667 0.593887900846608 926640.0 67465.806451613 0.402560771527032 1.312 0.9362 2072839 Maybridge1_006511 CCOC(=O)CNc1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P22 compound treatment 920640.0 21600.0 0.12 1027090.0 83800.0 0.42 1043320.0 137915.666666667 0.759267110938153 988590.0 129415.806451613 0.7722093551245 1.0371 0.8881 2072840 Maybridge1_006512 CC1CC2CN(C)C1C/C(=N/O)/C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P23 mock treatment 951840.0 52800.0 0.3 1038880.0 95600.0 0.48 1026990.0 121585.666666667 0.669365562975605 1083520.0 224345.806451613 1.33864583681792 1.394 0.8713 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.559 P24 mock treatment 868770.0 -30300.0 -0.17 934750.0 -8510.0 -0.04 989720.0 84315.666666667 0.464183034343387 1002930.0 143755.806451613 0.857774499414858 0.5533 0.558 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A01 compound treatment 1004000.0 33100.0 0.19 884710.0 -37500.0 -0.19 981600.0 -84311.5625 -0.464160439674896 -0.2672 -0.4993 2072841 Maybridge1_006513 CN1CC2CCC1C/C(=N/O)/C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A02 compound treatment 1012480.0 41600.0 0.24 946100.0 23900.0 0.12 1032260.0 -33651.5625 -0.18526194489335 0.0991 0.3059 2072842 Maybridge1_006514 COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c3cccc(c3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A03 compound treatment 1115200.0 144000.0 0.82 937540.0 15300.0 0.08 1095580.0 29668.4375 0.1633336470839 0.6144 0.7283 1577271 Maybridge1_006515 Fc1cccc(OCC(=O)Nc2ccccc2C(=O)c3ccccc3Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A04 compound treatment 1094400.0 123000.0 0.71 919470.0 -2730.0 -0.01 969800.0 -96111.5625 -0.529122978925236 0.0939 0.1064 2072843 Maybridge1_006516 Cc1cccc(c1)n2c(S)nnc2CSCc3cccc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A05 compound treatment 984850.0 13900.0 0.08 893950.0 -28200.0 -0.14 973980.0 -91931.5625 -0.506110825190793 -0.3279 -0.6169 1557801 Maybridge1_006517 COc1ccc(CC2CCC(=NO)CC2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A06 compound treatment 1174980.0 204000.0 1.17 976570.0 54400.0 0.27 1097690.0 31778.4375 0.17494982994985 0.931 0.7696 2072844 Maybridge1_006518 CN(C(=O)CSc1nnc(COc2ccc(C)c3CCCc32)n1c4ccccc4)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A07 compound treatment 975590.0 4660.0 0.03 968040.0 45800.0 0.23 1106720.0 40808.4375 0.22466268837617 0.2775 0.8614 1285371 Maybridge1_006519 COc1ccc(cc1)C(=O)N2CCC(CC2)c3ccccc3OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A08 compound treatment 1178810.0 208000.0 1.19 999940.0 77700.0 0.39 1073030.0 7118.4375 0.0391891335165122 0.9327 0.7461 1737597 Maybridge1_006520 OC(=O)CCC1CCCC(CCC(=O)O)C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A09 compound treatment 1083240.0 112000.0 0.64 932500.0 10300.0 0.05 1063630.0 -2281.5625 -0.0125606858863012 0.3929 0.6103 1393835 Maybridge1_006521 CC(=O)N(O)CC(=O)Nc1ccccc1C(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A10 compound treatment 1219580.0 249000.0 1.42 982190.0 60000.0 0.3 1094620.0 28708.4375 0.158048559144889 1.0846 0.7427 1166338 Maybridge1_006522 Cc1onc(c1C(=O)NCC(=O)O)c2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A11 compound treatment 1142410.0 171000.0 0.98 927700.0 5500.0 0.03 1046300.0 -19611.5625 -0.107967533785318 0.5191 0.5265 1059002 Maybridge1_006523 OC(=O)CSCc1cccc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A12 compound treatment 1078630.0 108000.0 0.62 1049690.0 127000.0 0.64 1093350.0 27438.4375 0.151056828225573 0.8106 0.9018 2072845 Maybridge1_006524 Cc1ccc(OCc2nnc(SCC(=O)c3ccc(F)c(F)c3)n2c4ccccc4)c5CCCc51 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A13 compound treatment 1219080.0 248000.0 1.42 1003320.0 81100.0 0.41 1087060.0 21148.4375 0.11642849162518 1.1199 0.7572 1464667 Maybridge1_006525 COc1ccc(cc1)S(=O)(=O)N2CCC(CC2)c3ccccc3OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A14 compound treatment 1171300.0 200000.0 1.14 972050.0 49900.0 0.25 1094640.0 28728.4375 0.158158665143618 0.8961 0.7581 1370472 Maybridge1_006526 COc1ccc(cc1)C(=O)c2cc3cc(Br)cc(Br)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A15 compound treatment 1116840.0 146000.0 0.83 952520.0 30300.0 0.15 1141280.0 75368.4375 0.414925854180557 0.8084 0.8569 1250811 Maybridge1_006527 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3cc(Cl)cc(Cl)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A16 compound treatment 1263450.0 293000.0 1.67 1013600.0 91400.0 0.46 1125030.0 59118.4375 0.325464730212927 1.4166 0.8036 1338954 Maybridge1_006528 COc1ccc(cc1)C(=O)c2cc3cc(Cl)cc(Cl)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A17 compound treatment 1219300.0 248000.0 1.42 977760.0 55600.0 0.28 1112850.0 46938.4375 0.258410176986728 1.1288 0.7686 2072846 Maybridge1_006529 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccc(OC(F)(F)F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A18 compound treatment 991560.0 20600.0 0.12 837490.0 -84700.0 -0.42 910140.0 -155771.5625 -0.857569173135007 -0.6717 -0.6969 2072847 Maybridge1_006530 Cc1cc(Br)c(OCc2nnc(S)n2CC=C)c3CCCc31 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A19 compound treatment 1217150.0 246000.0 1.41 979070.0 56900.0 0.28 1125730.0 59818.4375 0.329318440168456 1.1664 0.7922 2072848 Maybridge1_006531 OC(=O)CCCNCc1cccc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A20 compound treatment 1175360.0 204000.0 1.17 947260.0 25100.0 0.13 1138720.0 72808.4375 0.400832286343195 0.978 0.7881 2072849 Maybridge1_006532 Cc1onc(c1C(=O)Nc2cc(ccc2Oc3ccc(C)c4CCCc43)C(F)(F)F)c5c(F)cccc5Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A21 compound treatment 1107200.0 136000.0 0.78 983920.0 61700.0 0.31 1093040.0 27128.4375 0.149350185245267 0.7139 0.8392 2072850 Maybridge1_006533 Clc1ccccc1NC(=S)NNC(=O)CSCc2cccc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A22 compound treatment 1063730.0 92800.0 0.53 1019250.0 97100.0 0.49 1077600.0 11688.4375 0.0643483542261779 0.6235 0.8639 2072851 Maybridge1_006534 Cc1ccc(Oc2ccc(cc2NS(=O)(=O)c3cc(ccc3C)[N+](=O)[O-])C(F)(F)F)c4CCCc41 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A23 mock treatment 1107520.0 137000.0 0.78 1028800.0 107000.0 0.53 1107450.0 41538.4375 0.228681557329793 0.8904 0.9157 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 A24 mock treatment 1091970.0 121000.0 0.69 1019040.0 96800.0 0.48 1019620.0 -46291.5625 -0.254848936090325 0.5317 0.603 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B01 compound treatment 987300.0 16400.0 0.09 930050.0 7850.0 0.04 1002720.0 -63191.5625 -0.347888505016659 -0.1242 -0.3427 1671490 Maybridge1_006535 Cc1cccc(C)c1NC(=O)c2cccc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B02 compound treatment 1042880.0 72000.0 0.41 745160.0 -177000.0 -0.89 985480.0 -80431.5625 -0.442799875921394 -0.5296 -0.494 2072852 Maybridge1_006536 CCOC(=O)/C(=C/Nc1ccccc1Cl)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B03 compound treatment 602320.0 -369000.0 -2.11 598580.0 -324000.0 -1.62 598900.0 -467011.5625 -2.57103872536178 -3.6346 -0.9833 2072853 Maybridge1_006537 CC(=O)c1ccc(Nc2cc(C)nc3ccccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B04 compound treatment 893960.0 -77000.0 -0.44 768560.0 -154000.0 -0.77 950440.0 -115471.5625 -0.635705585695286 -1.0645 -0.9767 2072854 Maybridge1_006538 Cc1c(sc2ccccc12)C(=O)COc3nc(cc(c3C#N)C(F)(F)F)c4cccs4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B05 compound treatment 909860.0 -61100.0 -0.35 756590.0 -166000.0 -0.83 858240.0 -207671.5625 -1.14329423983778 -1.3397 -0.9212 2072855 Maybridge1_006539 [O-][N+](=O)c1cc(ccc1NCCNC(=O)c2cccs2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B06 compound treatment 972730.0 1800.0 0.01 782460.0 -140000.0 -0.7 909930.0 -155981.5625 -0.858725286121666 -0.8934 -0.8068 1292709 Maybridge1_006540 Cc1ccc2cc(NC(=O)c3ccccc3C)ccc2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B07 compound treatment 969680.0 -1250.0 -0.01 871280.0 -50900.0 -0.25 955410.0 -110501.5625 -0.608344245011032 -0.5024 -0.7617 2072856 Maybridge1_006541 CC(=O)C(=NNc1cccc(c1)C(F)(F)F)C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B08 compound treatment 987870.0 16900.0 0.1 802750.0 -119000.0 -0.6 1087480.0 21568.4375 0.118740717598497 -0.2205 -0.3575 2072857 Maybridge1_006542 NC/1=NNC(=O)\C1=C/c2cc(ccc2N3CCOCC3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B09 compound treatment 888380.0 -82500.0 -0.47 751540.0 -171000.0 -0.85 842520.0 -223391.5625 -1.22983755483908 -1.4751 -0.9398 1521748 Maybridge1_006543 CC(C)(C)c1ccc(Oc2ncccc2NC(=O)c3ccccc3Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B10 compound treatment 1030190.0 59300.0 0.34 874080.0 -48100.0 -0.24 998750.0 -67161.5625 -0.369744545764443 -0.157 -0.2823 1438392 Maybridge1_006544 CC1(C)CC(=O)c2ccc(OCC(=O)O)cc2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B11 compound treatment 944120.0 -26800.0 -0.15 819460.0 -103000.0 -0.51 977670.0 -88241.5625 -0.485796268425221 -0.6656 -0.9199 2072858 Maybridge1_006545 COc1ccc(Oc2ncccc2NC(=O)Nc3cccc(c3)C(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B12 compound treatment 1140280.0 169000.0 0.97 814690.0 -108000.0 -0.54 976860.0 -89051.5625 -0.490255561373761 -0.035 -0.0289 1565207 Maybridge1_006546 Nc1nc2ccc(F)cc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B13 compound treatment 1252520.0 282000.0 1.61 905320.0 -16900.0 -0.08 989240.0 -76671.5625 -0.422099948160269 0.6363 0.3821 2072859 Maybridge1_006547 COc1ccc(Oc2ncccc2NC(=O)c3cccc4ccccc34)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B14 compound treatment 1029250.0 58300.0 0.33 836030.0 -86200.0 -0.43 1018020.0 -47891.5625 -0.263657415988676 -0.2087 -0.3448 2072860 Maybridge1_006548 O=C(CCCCC(=O)NCC(=O)ON1C(=O)CCC1=O)NCC(=O)ON2C(=O)CCC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B15 compound treatment 1006130.0 35200.0 0.2 896480.0 -25700.0 -0.13 1053960.0 -11951.5625 -0.0657969362719615 0.0039 0.0155 2072861 Maybridge1_006549 CC(C)(C)c1ccc(Oc2ncccc2NS(=O)(=O)c3ccccc3C(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B16 compound treatment 1086300.0 115000.0 0.66 825160.0 -97000.0 -0.49 1030680.0 -35231.5625 -0.193960318792972 -0.0117 -0.0139 1050253 Maybridge1_006550 CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B17 compound treatment 1031150.0 60200.0 0.34 862110.0 -60100.0 -0.3 915240.0 -150671.5625 -0.829492143459013 -0.4538 -0.4792 1543501 Maybridge1_006551 CCOc1ccc(CC(C(=O)O)C(=O)O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B18 compound treatment 873250.0 -97700.0 -0.56 702130.0 -220000.0 -1.1 829520.0 -236391.5625 -1.30140645401318 -1.709 -0.9529 2072862 Maybridge1_006552 Clc1c2C(=O)CC(=O)c2c(Cl)c(Cl)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B19 compound treatment 1153760.0 183000.0 1.04 854770.0 -67400.0 -0.34 1002810.0 -63101.5625 -0.347393028022377 0.2077 0.1804 2072863 Maybridge1_006553 CC(=O)c1sc(nc1C)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B20 compound treatment 890190.0 -80700.0 -0.46 786590.0 -136000.0 -0.68 845240.0 -220671.5625 -1.21486313901188 -1.3593 -0.9273 2072864 Maybridge1_006554 COc1ccc(C=C2CCC(=O)CC2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B21 compound treatment 990970.0 20000.0 0.11 813620.0 -109000.0 -0.54 916040.0 -149871.5625 -0.825087903509837 -0.7238 -0.7279 1015396 Maybridge1_006555 O=C(CC(=O)c1cccnc1)c2cccnc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B22 compound treatment 1109240.0 138000.0 0.79 910300.0 -11900.0 -0.06 1095560.0 29648.4375 0.16322354108517 0.516 0.6379 2072865 Maybridge1_006556 Cc1cc2/C(=N\O)/CCCc2nn1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B23 mock treatment 1231550.0 261000.0 1.49 1106720.0 185000.0 0.92 1182740.0 116828.4375 0.643175589546583 1.7637 0.9452 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 B24 mock treatment 1244320.0 273000.0 1.56 1044110.0 122000.0 0.61 1113610.0 47698.4375 0.262594204938445 1.4053 0.8281 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C01 compound treatment 988340.0 17400.0 0.1 816510.0 -106000.0 -0.53 1095270.0 29358.4375 0.161627004103594 -0.1544 -0.275 1704397 Maybridge1_006557 COc1ccc(CCNC(=O)C2CCCO2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C02 compound treatment 805190.0 -166000.0 -0.95 796510.0 -126000.0 -0.63 845190.0 -220721.5625 -1.2151384040087 -1.6111 -0.9684 1520985 Maybridge1_006558 COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c3c(Cl)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C03 compound treatment 802560.0 -168000.0 -0.96 725690.0 -197000.0 -0.98 799840.0 -266071.5625 -1.46480375612759 -1.9684 -0.9797 2072866 Maybridge1_006559 Cn1cnnc1SCc2cccc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C04 compound treatment 747690.0 -223000.0 -1.28 721320.0 -201000.0 -1.0 782660.0 -283251.5625 -1.55938480903614 -2.2166 -0.9847 2072867 Maybridge1_006560 CCOC(=O)/C(=N/Nc1ccc(C)cc1)/C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C05 compound treatment 898290.0 -72600.0 -0.41 761390.0 -161000.0 -0.8 902560.0 -163351.5625 -0.899299346653446 -1.2231 -0.9587 2072868 Maybridge1_006561 Cn1c2CCC/C(=N\O)/c2c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C06 compound treatment 878330.0 -92600.0 -0.53 768000.0 -154000.0 -0.77 835520.0 -230391.5625 -1.26837465439436 -1.483 -0.941 1083147 Maybridge1_006562 Cc1cccc(c1)C(=O)NCC(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C07 compound treatment 862430.0 -108000.0 -0.62 793920.0 -128000.0 -0.64 906030.0 -159881.5625 -0.880195955873897 -1.2364 -0.9866 2072869 Maybridge1_006563 CC1(C)C(N)C2(C)CCC1C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C08 compound treatment 847440.0 -123000.0 -0.71 749130.0 -173000.0 -0.87 879650.0 -186261.5625 -1.02542576819796 -1.4991 -0.9888 2072870 Maybridge1_006564 COc1ccc(OC)c(Sc2cc(c(Cl)cc2[N+](=O)[O-])n3cccc3)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C09 compound treatment 877030.0 -93900.0 -0.54 765230.0 -157000.0 -0.79 888130.0 -177781.5625 -0.978740824736701 -1.328 -0.9732 1028362 Maybridge1_006565 NC(=O)NC(=O)c1cccnc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C10 compound treatment 842200.0 -129000.0 -0.74 781530.0 -141000.0 -0.7 939060.0 -126851.5625 -0.698355898972309 -1.2339 -0.9997 2072871 Maybridge1_006566 FC(F)(F)c1ccc(cc1)C(=O)CSc2nnc(CSCc3cccc4ccccc34)n2c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C11 compound treatment 849930.0 -121000.0 -0.69 839170.0 -83000.0 -0.42 853490.0 -212421.5625 -1.16944441453601 -1.314 -0.925 2072872 Maybridge1_006567 [O-][N+](=O)c1cccc(c1)C(=O)Nc2nnc(SCC(=O)Nc3ccc4OCOc4c3)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C12 compound treatment 861130.0 -110000.0 -0.63 746590.0 -176000.0 -0.88 841870.0 -224041.5625 -1.23341599979778 -1.5813 -0.9648 2072873 Maybridge1_006568 [O-][N+](=O)c1ccc2oc(cc2c1)C(=O)c3ccc(F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C13 compound treatment 885480.0 -85400.0 -0.49 860100.0 -62100.0 -0.31 919840.0 -146071.5625 -0.804167763751253 -0.9254 -0.9341 2072874 Maybridge1_006569 Cc1nc(cn1Cc2ccc(F)cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C14 compound treatment 1016160.0 45200.0 0.26 794640.0 -128000.0 -0.64 851170.0 -214741.5625 -1.18221671038861 -0.9017 -0.6591 2072875 Maybridge1_006570 Clc1ccc(NC(=O)CN2CCCCC2)c(c1)C(=O)c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C15 compound treatment 878250.0 -92700.0 -0.53 742410.0 -180000.0 -0.9 867930.0 -197981.5625 -1.08994788345339 -1.4541 -0.9637 2072876 Maybridge1_006571 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C16 compound treatment 863480.0 -107000.0 -0.61 757500.0 -165000.0 -0.82 895410.0 -170501.5625 -0.938662241199203 -1.3719 -0.9859 2072877 Maybridge1_006572 FC(F)(F)Oc1ccc(cc1)C(=O)c2cc3cc(Cl)cc(Cl)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C17 compound treatment 1011960.0 41000.0 0.23 737170.0 -185000.0 -0.93 816060.0 -249851.5625 -1.37550779115806 -1.1931 -0.7126 1447824 Maybridge1_006573 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccc(F)cc3F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C18 compound treatment 872320.0 -98600.0 -0.56 836590.0 -85600.0 -0.43 978510.0 -87401.5625 -0.481171816478586 -0.8502 -0.9937 1633199 Maybridge1_006574 Clc1cc(Cl)c2oc(cc2c1)C(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C19 compound treatment 894000.0 -76900.0 -0.44 727680.0 -195000.0 -0.97 833190.0 -232721.5625 -1.28120200324634 -1.5551 -0.9325 1019887 Maybridge1_006575 OC1(C(=O)Nc2ccccc21)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C20 compound treatment 859890.0 -111000.0 -0.63 777350.0 -145000.0 -0.72 857620.0 -208291.5625 -1.14670752579839 -1.4465 -0.966 2072878 Maybridge1_006576 OS(=O)(=O)c1ccc(Nc2ncnc3cc(Cl)ccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C21 compound treatment 757170.0 -214000.0 -1.22 637600.0 -285000.0 -1.42 670910.0 -395001.5625 -2.17460207693661 -2.7823 -0.9689 2072879 Maybridge1_006577 Cc1cccc(NC(=S)NNC(=O)CSCc2cccc3ccccc23)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C22 compound treatment 806080.0 -165000.0 -0.94 712800.0 -209000.0 -1.05 740080.0 -325831.5625 -1.79380048033101 -2.184 -0.9576 1193041 Maybridge1_006578 Cc1ccc(C)n1c2ccc(cc2)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C23 mock treatment 921980.0 -48900.0 -0.28 875290.0 -46900.0 -0.23 965920.0 -99991.5625 -0.550483542678738 -0.6147 -0.9307 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 C24 mock treatment 878020.0 -92900.0 -0.53 825980.0 -96200.0 -0.48 890440.0 -175471.5625 -0.966023581883457 -1.142 -0.9495 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D01 compound treatment 1010100.0 39200.0 0.22 932260.0 10100.0 0.05 1042640.0 -23271.5625 -0.128116931552796 0.0843 0.3208 1425989 Maybridge1_006579 C1COC2(O1)C3NCC4(CCCCC4)CN3c5ccccc52 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D02 compound treatment 881410.0 -89500.0 -0.51 813170.0 -109000.0 -0.55 1019620.0 -46291.5625 -0.254848936090325 -0.7572 -0.9587 2072880 Maybridge1_006580 CN(C(=O)CSc1nccc(n1)c2sc(nc2C)c3ccc(Cl)cc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D03 compound treatment 812920.0 -158000.0 -0.9 788430.0 -134000.0 -0.67 820050.0 -245861.5625 -1.35354164441155 -1.6889 -0.9601 2072881 Maybridge1_006581 [O-][N+](=O)c1cc(ccc1NCCNC(=O)c2ccccc2F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D04 compound treatment 922460.0 -48500.0 -0.28 767000.0 -155000.0 -0.78 921630.0 -144281.5625 -0.794313276864972 -1.0666 -0.9318 2072882 Maybridge1_006582 COC(=O)/C(=C/c1cc(Br)c(OC(=O)C)c(OC)c1)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D05 compound treatment 810420.0 -161000.0 -0.92 757680.0 -165000.0 -0.82 827710.0 -238201.5625 -1.31137104689819 -1.7616 -0.979 2072883 Maybridge1_006583 [O-][N+](=O)c1cc(ccc1NCCNC(=S)Nc2ccccc2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D06 compound treatment 946160.0 -24800.0 -0.14 728830.0 -193000.0 -0.97 850040.0 -215871.5625 -1.18843769931683 -1.3262 -0.8619 1340853 Maybridge1_006584 Cc1ccc2cc(NC(=O)c3ccc(cc3)C(C)(C)C)ccc2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D07 compound treatment 904250.0 -66700.0 -0.38 739730.0 -182000.0 -0.91 826030.0 -239881.5625 -1.32061995079146 -1.5093 -0.9148 2072884 Maybridge1_006585 Cc1ccc(C)n1c2ccc(cc2)C(=O)NNS(=O)(=O)c3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D08 compound treatment 808160.0 -163000.0 -0.93 745070.0 -177000.0 -0.89 828040.0 -237871.5625 -1.30955429791915 -1.8044 -0.9837 2072885 Maybridge1_006586 COC(=O)/C(=C/c1ccc(OC)c(OC)c1Cl)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D09 compound treatment 853880.0 -117000.0 -0.67 859130.0 -63100.0 -0.32 897810.0 -168101.5625 -0.925449521351676 -1.1025 -0.9307 1483254 Maybridge1_006587 CCCc1ccc(cc1)C(=O)Nc2cccnc2Oc3ccc(cc3)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D10 compound treatment 814660.0 -156000.0 -0.89 760930.0 -161000.0 -0.81 907400.0 -158511.5625 -0.872653694960934 -1.4849 -0.9991 1594559 Maybridge1_006588 CCOC(=O)COc1ccc2C(=O)CC(C)(C)Oc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D11 compound treatment 868020.0 -103000.0 -0.59 723740.0 -198000.0 -0.99 885210.0 -180701.5625 -0.994816300551192 -1.4868 -0.976 2072886 Maybridge1_006589 COc1ccc(Oc2ncccc2NC(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D12 compound treatment 747780.0 -223000.0 -1.27 636170.0 -286000.0 -1.43 870680.0 -195231.5625 -1.07480830862809 -2.1825 -0.9934 2072887 Maybridge1_006590 C1C2C3C4C5C3C6OC5(C(C14)C26)c7ccccc7 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D13 compound treatment 1208700.0 238000.0 1.36 715570.0 -207000.0 -1.03 838650.0 -227261.5625 -1.25114306559321 -0.5348 -0.2527 2072888 Maybridge1_006591 CCCCCCCCCC(=O)n1c2ccc(F)cc2c3nc4ccccc4nc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D14 compound treatment 688440.0 -282000.0 -1.61 614750.0 -307000.0 -1.54 848450.0 -217461.5625 -1.19719112621581 -2.5107 -0.9923 2072889 Maybridge1_006592 [O-][N+](=O)c1cccc2C(=O)CC(=O)c21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D15 compound treatment 816070.0 -155000.0 -0.88 763930.0 -158000.0 -0.79 844590.0 -221321.5625 -1.21844158397058 -1.6712 -0.9824 2072890 Maybridge1_006593 [O-][N+](=O)c1cc(Cl)c(cc1Sc2ccc(F)cc2Cl)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D16 compound treatment 916160.0 -54800.0 -0.31 741760.0 -180000.0 -0.9 945610.0 -120301.5625 -0.662296184388434 -1.084 -0.9327 2072891 Maybridge1_006594 CC(=O)N[C@@H](Cc1ccc(OC(=O)C)cc1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D17 compound treatment 592260.0 -379000.0 -2.16 776920.0 -145000.0 -0.73 965010.0 -100901.5625 -0.555493365620925 -1.9891 -0.847 1129476 Maybridge1_006595 Clc1ccc(Sc2ncccc2NC(=O)C(C3CCCC3)c4ccccc4)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D18 compound treatment 880480.0 -90400.0 -0.52 876580.0 -45600.0 -0.23 901520.0 -164391.5625 -0.905024858587374 -0.9525 -0.8929 1547187 Maybridge1_006596 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D19 compound treatment 1030690.0 59800.0 0.34 803840.0 -118000.0 -0.59 859230.0 -206681.5625 -1.13784399290067 -0.8016 -0.6039 2072892 Maybridge1_006597 FC(F)(F)c1cc([nH]c(=O)c1C#N)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D20 compound treatment 735390.0 -236000.0 -1.35 675140.0 -247000.0 -1.24 736760.0 -329151.5625 -1.81207807612009 -2.5364 -0.9858 1554163 Maybridge1_006598 OC(C(=O)Nc1ccc(Cl)cc1)c2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D21 compound treatment 745760.0 -225000.0 -1.29 687070.0 -235000.0 -1.18 779480.0 -286431.5625 -1.57689166283411 -2.332 -0.9922 2072893 Maybridge1_006599 COc1ccc(cc1)C(=O)CN2CCN(CC2)c3cc(C)nc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D22 compound treatment 750930.0 -220000.0 -1.26 614190.0 -308000.0 -1.54 698620.0 -367291.5625 -2.02205021569704 -2.7824 -0.9812 2072894 Maybridge1_006600 CC(C)(NO)/C(=N\O)/c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D23 mock treatment 916220.0 -54700.0 -0.31 1070400.0 148000.0 0.74 928640.0 -137271.5625 -0.755721124310321 -0.1888 -0.171 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 D24 mock treatment 991840.0 20900.0 0.12 989680.0 67500.0 0.34 1134760.0 68848.4375 0.379031298594775 0.4827 0.9257 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E01 compound treatment 1113720.0 143000.0 0.82 955680.0 33500.0 0.17 963580.0 -102331.5625 -0.563365944530076 0.2424 0.2411 1627375 Maybridge1_006601 CN1C(=O)CN=C(c2ccccc2)c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E02 compound treatment 823740.0 -147000.0 -0.84 903300.0 -18900.0 -0.09 889490.0 -176421.5625 -0.971253616823103 -1.1008 -0.8546 2072895 Maybridge1_006602 Sc1nnc(CSCc2cccc3ccccc23)n1c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E03 compound treatment 476390.0 -495000.0 -2.83 416800.0 -505000.0 -2.53 530340.0 -535571.5625 -2.94848208900613 -4.7928 -0.998 2072896 Maybridge1_006603 COc1ccccc1C2CCN(CC2)c3ccc(CO)cc3[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E04 compound treatment 762520.0 -208000.0 -1.19 694370.0 -228000.0 -1.14 834210.0 -231701.5625 -1.27558659731114 -2.0817 -0.9989 2072897 Maybridge1_006604 Nc1nnc(Sc2cc(c(Cl)cc2[N+](=O)[O-])n3cccc3)[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E05 compound treatment 812020.0 -159000.0 -0.91 694430.0 -228000.0 -1.14 765180.0 -300731.5625 -1.65561745192563 -2.1377 -0.9694 1141662 Maybridge1_006605 COc1ccccc1C2CCN(CC2)C(=O)c3c(C)onc3c4c(Cl)cccc4Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E06 compound treatment 818080.0 -153000.0 -0.87 795780.0 -126000.0 -0.63 1182170.0 116258.4375 0.640037568582795 -0.4996 -0.3985 2072898 Maybridge1_006606 Cc1ccc(OCc2nnc(SCC(=O)Nc3ccc(cc3)C4CCCCC4)n2c5ccccc5)c6CCCc61 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E07 compound treatment 930300.0 -40600.0 -0.23 1098020.0 176000.0 0.88 1070510.0 4598.4375 0.025315777676609 0.3883 0.4268 1914101 Maybridge1_006607 OC(=O)c1ccccc1C(=O)Nc2ccc(Br)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E08 compound treatment 877820.0 -93100.0 -0.53 744720.0 -177000.0 -0.89 958260.0 -107651.5625 -0.592654140192094 -1.1617 -0.9742 2072899 Maybridge1_006608 CCOC(=O)CCSc1cc(c(Cl)cc1[N+](=O)[O-])n2cccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E09 compound treatment 847400.0 -124000.0 -0.71 778510.0 -144000.0 -0.72 883470.0 -182441.5625 -1.00439552244065 -1.4022 -0.9858 1225998 Maybridge1_006609 Clc1ccc(OC2CN(C2)C(c3ccccc3)c4ccccc4)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E10 compound treatment 879220.0 -91700.0 -0.52 723910.0 -198000.0 -0.99 912000.0 -153911.5625 -0.847329315253174 -1.3643 -0.9705 2072900 Maybridge1_006610 [O-][N+](=O)c1ccc2oc(cc2c1)C(=O)c3cccc(Cl)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E11 compound treatment 762350.0 -209000.0 -1.19 827040.0 -95200.0 -0.48 891000.0 -174911.5625 -0.962940613919034 -1.5186 -0.9467 1666166 Maybridge1_006611 O=C1N(CCC#N)C2CCCCC2C31OCCO3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E12 compound treatment 835360.0 -136000.0 -0.77 778950.0 -143000.0 -0.72 910120.0 -155791.5625 -0.857679279133737 -1.3559 -0.9973 2072901 Maybridge1_006612 [O-][N+](=O)c1cc(Cl)c(cc1N2CCOCC2)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E13 compound treatment 937840.0 -33100.0 -0.19 782970.0 -139000.0 -0.7 946010.0 -119901.5625 -0.660094064413846 -0.8923 -0.9124 1653130 Maybridge1_006613 COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c3cc(C)no3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E14 compound treatment 825600.0 -145000.0 -0.83 665160.0 -257000.0 -1.29 854240.0 -211671.5625 -1.16531543958365 -1.8943 -0.9848 2072902 Maybridge1_006614 Clc1ccc(NC(=O)CN2CCOCC2)c(c1)C(=O)c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E15 compound treatment 915110.0 -55800.0 -0.32 779310.0 -143000.0 -0.71 866730.0 -199181.5625 -1.09655424337715 -1.2298 -0.9129 1328099 Maybridge1_006615 CCCCc1ccc(cc1)S(=O)(=O)N2CCC(CC2)c3ccccc3OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E16 compound treatment 759000.0 -212000.0 -1.21 625640.0 -297000.0 -1.48 747840.0 -318071.5625 -1.75107935282401 -2.5663 -0.9891 2072903 Maybridge1_006616 COc1cc(I)c(OC)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E17 compound treatment 721960.0 -249000.0 -1.42 651600.0 -271000.0 -1.35 753610.0 -312301.5625 -1.71931377219058 -2.5952 -0.9944 2072904 Maybridge1_006617 CCCCOc1ccc(cc1)S(=O)(=O)NC(Cc2c[nH]c3ccccc23)C(=O)OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E18 compound treatment 803520.0 -167000.0 -0.96 825210.0 -97000.0 -0.49 1288640.0 222728.4375 1.2261868528187 -0.1243 -0.0763 1550589 Maybridge1_006618 Cc1ccc(C)c2c(O)ccnc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E19 compound treatment 1121380.0 150000.0 0.86 789520.0 -133000.0 -0.66 940540.0 -125371.5625 -0.690208055066334 -0.2854 -0.2218 2072905 Maybridge1_006619 CC(=O)Nc1cccc(OCCCN2C(=O)c3ccccc3C2=O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E20 compound treatment 754460.0 -216000.0 -1.24 747070.0 -175000.0 -0.88 970240.0 -95671.5625 -0.526700646953189 -1.5237 -0.9498 1437311 Maybridge1_006620 C1CN(C1)C=C(c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E21 compound treatment 739230.0 -232000.0 -1.32 598740.0 -323000.0 -1.62 731760.0 -334151.5625 -1.83960457580244 -2.7603 -0.9913 2072906 Maybridge1_006621 FC(F)(F)Oc1ccc(NC(=S)NNC(=O)CSCc2cccc3ccccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E22 compound treatment 856400.0 -115000.0 -0.65 785760.0 -136000.0 -0.68 895930.0 -169981.5625 -0.935799485232239 -1.312 -0.9863 2072907 Maybridge1_006622 Clc1ccc2c(=O)[nH]cnc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E23 mock treatment 962920.0 -8010.0 -0.05 824770.0 -97400.0 -0.49 979290.0 -86621.5625 -0.47687768252814 -0.5831 -0.8533 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 E24 mock treatment 1180960.0 210000.0 1.2 880290.0 -41900.0 -0.21 1030690.0 -35221.5625 -0.193905265793607 0.4597 0.3728 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F01 compound treatment 852180.0 -119000.0 -0.68 1082340.0 160000.0 0.8 873840.0 -192071.5625 -1.05741156082885 -0.5397 -0.3622 1196658 Maybridge1_006623 ON=C1CCN(Cc2ccccc2)CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F02 compound treatment 747450.0 -223000.0 -1.28 648390.0 -274000.0 -1.37 747240.0 -318671.5625 -1.75438253278589 -2.5406 -0.9902 2072908 Maybridge1_006624 CCOC(=O)COc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F03 compound treatment 806080.0 -165000.0 -0.94 678820.0 -243000.0 -1.22 755870.0 -310041.5625 -1.70687179433416 -2.2319 -0.9711 1065469 Maybridge1_006625 Oc1nc(nc2ccccc12)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F04 compound treatment 759390.0 -212000.0 -1.21 695220.0 -227000.0 -1.14 888840.0 -177071.5625 -0.974832061781808 -1.9159 -0.9961 2072909 Maybridge1_006626 CCOC(=O)/C(=C/Nc1cc(C)ccn1)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F05 compound treatment 888710.0 -82200.0 -0.47 661400.0 -261000.0 -1.3 760000.0 -305911.5625 -1.68413490559654 -1.9966 -0.9153 2072910 Maybridge1_006627 Cc1onc(c1C(=O)NCCNc2ccc(cc2[N+](=O)[O-])C(F)(F)F)c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F06 compound treatment 829120.0 -142000.0 -0.81 764420.0 -158000.0 -0.79 820720.0 -245191.5625 -1.34985309345411 -1.7026 -0.9669 1642696 Maybridge1_006628 COc1ccc(cc1)C(=O)c2oc3ccc4ccccc4c3c2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F07 compound treatment 854270.0 -117000.0 -0.67 724800.0 -197000.0 -0.99 875200.0 -190711.5625 -1.04992435291525 -1.5609 -0.9831 2072911 Maybridge1_006629 CCCc1ccc(cc1)S(=O)(=O)NNC(=O)c2ccc(cc2)n3c(C)ccc3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F08 compound treatment 782880.0 -188000.0 -1.07 737150.0 -185000.0 -0.93 907060.0 -158851.5625 -0.874525496939333 -1.6595 -0.9961 2072912 Maybridge1_006630 CC(=O)CC1(O)C(=O)Nc2ccc(F)cc21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F09 compound treatment 805670.0 -165000.0 -0.94 669820.0 -252000.0 -1.26 909600.0 -156311.5625 -0.860542035100701 -1.7706 -0.986 2072913 Maybridge1_006631 CC(C)(C)c1ccc(Oc2ncccc2NC(=O)c3ccccc3C(F)(F)F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F10 compound treatment 772480.0 -198000.0 -1.13 593300.0 -329000.0 -1.65 701600.0 -364311.5625 -2.00564442188636 -2.7622 -0.9757 1110972 Maybridge1_006632 C1=CC(=C(c2ccccc2)c3ccccc3)C=C1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F11 compound treatment 872550.0 -98400.0 -0.56 753700.0 -168000.0 -0.84 942030.0 -123881.5625 -0.682005158160994 -1.2048 -0.9866 2072914 Maybridge1_006633 CCC(=O)Nc1cc(C)cc(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F12 compound treatment 858600.0 -112000.0 -0.64 809690.0 -113000.0 -0.56 1077570.0 11658.4375 0.0641831952280838 -0.6583 -0.7692 1246126 Maybridge1_006634 NC(=O)CC1(CC2CC3CC(C2)C1)C3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F13 compound treatment 853020.0 -118000.0 -0.67 756530.0 -166000.0 -0.83 904590.0 -161321.5625 -0.888123587782413 -1.38 -0.9936 2072915 Maybridge1_006635 CCCCCC(=O)n1c2ccc(F)cc2c3nc4ccccc4nc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F14 compound treatment 871010.0 -99900.0 -0.57 788720.0 -133000.0 -0.67 892870.0 -173041.5625 -0.952645703037836 -1.265 -0.9762 1441808 Maybridge1_006636 Oc1c(c2ccccc2)c(=O)n3CCCc4cccc1c43 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F15 compound treatment 889520.0 -81400.0 -0.47 687840.0 -234000.0 -1.17 828190.0 -237721.5625 -1.30872850292868 -1.7008 -0.9359 1565903 Maybridge1_006637 CC(C)(C)OC(=O)C(C)(C)Sc1nc(c(o1)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F16 compound treatment 744530.0 -226000.0 -1.29 792130.0 -130000.0 -0.65 797820.0 -268091.5625 -1.47592446199926 -1.9744 -0.955 2072916 Maybridge1_006638 CC(C)(C)OC(=O)N[C@@H](CCCNC(=N)N)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F17 compound treatment 832270.0 -139000.0 -0.79 746090.0 -176000.0 -0.88 878340.0 -187571.5625 -1.03263771111474 -1.562 -0.994 1378454 Maybridge1_006639 Cc1ccc(Sc2ncccc2n3cccc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F18 compound treatment 827950.0 -143000.0 -0.82 838760.0 -83400.0 -0.42 1002300.0 -63611.5625 -0.350200730989977 -0.9147 -0.9317 1185730 Maybridge1_006640 O=C1N(CC2(CCC=CC2)C#N)c3ccccc3C41OCCO4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F19 compound treatment 1001920.0 31000.0 0.18 707520.0 -215000.0 -1.07 882800.0 -183111.5625 -1.00808407339808 -1.0997 -0.7413 2072917 Maybridge1_006641 CCOC(=O)CSc1nc2cc(Cl)ccc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F20 compound treatment 851810.0 -119000.0 -0.68 727520.0 -195000.0 -0.97 908320.0 -157591.5625 -0.867588819019382 -1.4559 -0.9898 2072918 Maybridge1_006642 CNS(=O)(=O)Cc1ccc(cc1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F21 compound treatment 882890.0 -88000.0 -0.5 724350.0 -198000.0 -0.99 888600.0 -177311.5625 -0.976153333766561 -1.4253 -0.9642 2072919 Maybridge1_006643 Cc1[nH]c(=O)c(C#N)c(C)c1CC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F22 compound treatment 940080.0 -30800.0 -0.18 779870.0 -142000.0 -0.71 954200.0 -111711.5625 -0.61500565793416 -0.8678 -0.9067 2072920 Maybridge1_006644 CC(C)(NO)C(=O)c1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F23 mock treatment 922570.0 -48400.0 -0.28 793620.0 -129000.0 -0.64 1096840.0 30928.4375 0.170270325003851 -0.4325 -0.6004 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 F24 mock treatment 862960.0 -108000.0 -0.62 910320.0 -11900.0 -0.06 1111850.0 45938.4375 0.252904877050259 -0.2444 -0.3651 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G01 compound treatment 1126950.0 156000.0 0.89 999160.0 77000.0 0.38 1046240.0 -19671.5625 -0.108297851781506 0.6743 0.6903 1576730 Maybridge1_006645 Nc1nnc(SCC(=O)Nc2ccc3OCOc3c2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G02 compound treatment 814960.0 -156000.0 -0.89 788530.0 -134000.0 -0.67 785560.0 -280351.5625 -1.54341943922038 -1.7915 -0.9412 1130064 Maybridge1_006646 COc1ccccc1N2CCN(CC(C)N(C(=O)C3CCCCC3)c4ccccn4)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G03 compound treatment 696600.0 -274000.0 -1.57 702580.0 -220000.0 -1.1 720960.0 -344951.5625 -1.89906181511631 -2.6354 -0.9775 2072921 Maybridge1_006647 Clc1cccc(SCc2cccc3ccccc23)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G04 compound treatment 743580.0 -227000.0 -1.3 675410.0 -247000.0 -1.23 714110.0 -351801.5625 -1.93677311968113 -2.5806 -0.9781 2072922 Maybridge1_006648 Cc1ccc(OCc2nnc(S)n2c3ccccc3)c4CCCc41 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G05 compound treatment 832540.0 -138000.0 -0.79 736000.0 -186000.0 -0.93 884050.0 -181861.5625 -1.0012024484775 -1.5721 -0.9954 2072923 Maybridge1_006649 COc1ccccc1C2CCN(CC2)C(=O)c3ccccc3C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G06 compound treatment 518570.0 -452000.0 -2.58 553860.0 -368000.0 -1.84 622880.0 -443031.5625 -2.43902163288524 -3.9637 -0.9903 2072924 Maybridge1_006650 Cc1ccc(OCc2nnc(SCC(=O)Nc3cccc4OCOc43)n2c5ccccc5)c6CCCc61 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G07 compound treatment 1241700.0 271000.0 1.55 718410.0 -204000.0 -1.02 947080.0 -118831.5625 -0.654203393481823 -0.0731 -0.0372 1072142 Maybridge1_006651 C1COC2(CCC3(CC2)OCCO3)O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G08 compound treatment 838350.0 -133000.0 -0.76 752680.0 -170000.0 -0.85 958210.0 -107701.5625 -0.592929405188918 -1.2691 -0.9898 2072925 Maybridge1_006652 Cc1ccc(OCc2nnc(SCC(=O)c3ccc(cc3)[N+](=O)[O-])n2c4ccccc4)c5CCCc51 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G09 compound treatment 879680.0 -91200.0 -0.52 744100.0 -178000.0 -0.89 888240.0 -177671.5625 -0.97813524174369 -1.38 -0.9705 1059089 Maybridge1_006653 O=C1NNC(C1c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G10 compound treatment 793830.0 -177000.0 -1.01 687540.0 -235000.0 -1.17 844640.0 -221271.5625 -1.21816631897376 -1.965 -0.997 2072926 Maybridge1_006654 [O-][N+](=O)c1cc(Cl)c(cc1N2CCCCC2)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G11 compound treatment 739630.0 -231000.0 -1.32 679790.0 -242000.0 -1.21 833940.0 -231971.5625 -1.27707302829398 -2.2001 -0.9994 2072927 Maybridge1_006655 [O-][N+](=O)c1cccc(c1)C(=O)Oc2ccc(Oc3ccccc3)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G12 compound treatment 764230.0 -207000.0 -1.18 808720.0 -113000.0 -0.57 1037410.0 -28501.5625 -0.156909650220532 -1.1 -0.8337 2072928 Maybridge1_006656 [O-][N+](=O)c1cc(Cl)c(cc1N2CCCC2)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G13 compound treatment 755290.0 -216000.0 -1.23 630000.0 -292000.0 -1.46 788270.0 -277641.5625 -1.52850007639255 -2.4374 -0.9959 1573326 Maybridge1_006657 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3cc(Cl)cc(Cl)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G14 compound treatment 680800.0 -290000.0 -1.66 516290.0 -406000.0 -2.03 708970.0 -356941.5625 -1.96507036135458 -3.2635 -0.9963 1433613 Maybridge1_006658 Brc1ccc(cc1)C(=O)c2cc3cc(Br)cc(Br)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G15 compound treatment 797340.0 -174000.0 -0.99 667650.0 -255000.0 -1.27 816160.0 -249751.5625 -1.37495726116441 -2.1014 -0.9912 2072929 Maybridge1_006659 [O-][N+](=O)c1ccc(o1)C2NC(=O)c3c4CCCCc4sc3N2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G16 compound treatment 784160.0 -187000.0 -1.07 673130.0 -249000.0 -1.25 777650.0 -288261.5625 -1.58696636171785 -2.2514 -0.9865 2072930 Maybridge1_006660 [O-][N+](=O)c1cccc(c1)c2csc(=Nc3ccccc3)n2c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G17 compound treatment 784990.0 -186000.0 -1.06 763370.0 -159000.0 -0.79 900700.0 -165211.5625 -0.909539204535279 -1.597 -0.993 2072931 Maybridge1_006661 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccccc3C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G18 compound treatment 1075400.0 104000.0 0.6 851740.0 -70500.0 -0.35 881980.0 -183931.5625 -1.01259841934599 -0.4435 -0.3614 1731945 Maybridge1_006662 COc1cc(CCC(C)N)ccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G19 compound treatment 653850.0 -317000.0 -1.81 591730.0 -330000.0 -1.65 704730.0 -361181.5625 -1.98841283308521 -3.148 -0.9972 2072932 Maybridge1_006663 CC(C)(C)c1ccc(cc1)C(=O)O/N=C/c2ccc3OCOc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G20 compound treatment 714900.0 -256000.0 -1.46 757570.0 -165000.0 -0.82 893120.0 -172791.5625 -0.951269378053718 -1.869 -0.9688 1589048 Maybridge1_006664 CCC(=O)Cc1c(C)[nH]c2ccc(OC)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G21 compound treatment 797530.0 -173000.0 -0.99 703060.0 -219000.0 -1.1 770810.0 -295101.5625 -1.6246226132833 -2.1427 -0.9758 2072933 Maybridge1_006665 COc1ccc(NC(=S)NNC(=O)CSCc2cccc3ccccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G22 compound treatment 817610.0 -153000.0 -0.88 765120.0 -157000.0 -0.79 800480.0 -265431.5625 -1.46128036416825 -1.8029 -0.961 1004920 Maybridge1_006666 OC(=O)Cc1ccc(F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G23 mock treatment 930450.0 -40500.0 -0.23 830350.0 -91800.0 -0.46 888500.0 -177411.5625 -0.976703863760208 -0.9626 -0.8721 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 G24 mock treatment 937180.0 -33700.0 -0.19 889390.0 -32800.0 -0.16 1005070.0 -60841.5625 -0.334951050165956 -0.3994 -0.9513 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H01 compound treatment 951060.0 -19900.0 -0.11 761760.0 -160000.0 -0.8 842160.0 -223751.5625 -1.2318194628162 -1.24 -0.841 1522882 Maybridge1_006667 Cc1ccc(C)n1c2ccc(cc2)C(=O)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H02 compound treatment 717600.0 -253000.0 -1.45 595170.0 -327000.0 -1.64 826350.0 -239561.5625 -1.31885825481179 -2.5413 -0.9961 2072934 Maybridge1_006668 COc1ccc(cc1)C(=O)COc2nc(cc(c2C#N)C(F)(F)F)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H03 compound treatment 579360.0 -392000.0 -2.24 587090.0 -335000.0 -1.68 696010.0 -369901.5625 -2.03641904853122 -3.4348 -0.9932 2072935 Maybridge1_006669 Cc1ccc(cc1)S(=O)(=O)NCCNc2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H04 compound treatment 761830.0 -209000.0 -1.19 675810.0 -246000.0 -1.23 759390.0 -306521.5625 -1.68749313855779 -2.3754 -0.9869 2072936 Maybridge1_006670 CCOC(=O)/C(=C/Nc1ccc2OCOc2c1)/C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H05 compound treatment 782400.0 -189000.0 -1.08 658500.0 -264000.0 -1.32 780420.0 -285491.5625 -1.57171668089383 -2.2907 -0.9885 2072937 Maybridge1_006671 Cc1onc(c1C(=O)NCCNc2ccc(cc2[N+](=O)[O-])C(F)(F)F)c3c(F)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H06 compound treatment 39610.0 -931000.0 -5.32 30880.0 -891000.0 -4.46 36920.0 -1028991.5625 -5.66490718365892 -8.916 -0.9952 2072938 Maybridge1_006672 CC1(C)N=c2ccc(cc2=N1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H07 compound treatment 858630.0 -112000.0 -0.64 714940.0 -207000.0 -1.04 908740.0 -157171.5625 -0.865276593046065 -1.4684 -0.9823 2072939 Maybridge1_006673 Cc1ccc(C)n1c2ccc(cc2)C(=O)NNS(=O)(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H08 compound treatment 771480.0 -199000.0 -1.14 681280.0 -241000.0 -1.2 764640.0 -301271.5625 -1.65859031389132 -2.3111 -0.9854 1147764 Maybridge1_006674 COC(=O)c1cccnc1Sc2ccc(C)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H09 compound treatment 925140.0 -45800.0 -0.26 644010.0 -278000.0 -1.39 724030.0 -341881.5625 -1.88216054431135 -2.041 -0.8666 1479714 Maybridge1_006675 COc1ccc(cc1OC)C(=O)Nc2cccnc2Oc3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H10 compound treatment 600250.0 -371000.0 -2.12 540700.0 -381000.0 -1.91 659640.0 -406271.5625 -2.23664680722062 -3.6155 -0.9979 2072940 Maybridge1_006676 O=C(N/N=C/1\C(=O)Nc2ccccc12)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H11 compound treatment 857480.0 -113000.0 -0.65 745600.0 -177000.0 -0.88 865510.0 -200401.5625 -1.10327070929964 -1.5211 -0.9783 1528049 Maybridge1_006677 CCC(=O)Nc1cc(OC)cc(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H12 compound treatment 996640.0 25700.0 0.15 816350.0 -106000.0 -0.53 1035040.0 -30871.5625 -0.169957211069965 -0.319 -0.5546 2072941 Maybridge1_006678 OC(=O)C1(CC2CC3C1)CC(C2)(C3)c4ccc(cc4)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H13 compound treatment 919840.0 -51100.0 -0.29 715930.0 -206000.0 -1.03 900730.0 -165181.5625 -0.909374045537185 -1.2891 -0.917 1468197 Maybridge1_006679 Clc1ccc(Oc2ncccc2NS(=O)(=O)c3ccc(Cl)cc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H14 compound treatment 1254850.0 284000.0 1.62 811170.0 -111000.0 -0.56 945500.0 -120411.5625 -0.662901767381445 0.2331 0.1268 1264289 Maybridge1_006680 COc1ccc2c(O)c(Cc3ccccc3)c(=O)[nH]c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H15 compound treatment 799270.0 -172000.0 -0.98 739010.0 -183000.0 -0.92 917020.0 -148891.5625 -0.819692709572097 -1.5684 -0.9973 2072942 Maybridge1_006681 Cc1nc(cn1CC=C)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H16 compound treatment 892170.0 -78800.0 -0.45 746760.0 -175000.0 -0.88 892320.0 -173591.5625 -0.955673618002894 -1.3181 -0.9599 2072943 Maybridge1_006682 N[C@@H](Cc1ccc(cc1)[N+](=O)[O-])C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H17 compound treatment 907300.0 -63600.0 -0.36 748230.0 -174000.0 -0.87 909410.0 -156501.5625 -0.86158804208863 -1.2096 -0.947 2072944 Maybridge1_006683 Cc1nc(cn1CC(=O)c2ccccc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H18 compound treatment 868160.0 -103000.0 -0.59 777000.0 -145000.0 -0.73 964820.0 -101091.5625 -0.556539372608854 -1.0795 -0.9931 2072945 Maybridge1_006684 COC(=O)C(C)(N)Cc1c[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H19 compound treatment 830350.0 -141000.0 -0.8 695620.0 -227000.0 -1.13 879400.0 -186511.5625 -1.02680209318208 -1.7107 -0.9904 2072946 Maybridge1_006685 CN(C(=O)CN1CCN(CC1)c2cc(C)nc3ccccc23)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H20 compound treatment 880570.0 -90400.0 -0.52 757540.0 -165000.0 -0.82 946850.0 -119061.5625 -0.655469612467211 -1.1519 -0.9826 1224541 Maybridge1_006686 O=C1CN=C(c2ccccc2)c3ccccc3N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H21 compound treatment 855840.0 -115000.0 -0.66 731950.0 -190000.0 -0.95 849880.0 -216031.5625 -1.18931854730666 -1.6156 -0.9739 2072947 Maybridge1_006687 Cc1cc(N2CCN(CC(=O)c3ccccc3)CC2)c4ccccc4n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H22 compound treatment 839650.0 -131000.0 -0.75 782340.0 -140000.0 -0.7 995430.0 -70481.5625 -0.388022141553522 -1.0608 -0.9675 1340087 Maybridge1_006688 Cc1cc2c(N)cccc2nn1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H23 mock treatment 923520.0 -47400.0 -0.27 830880.0 -91300.0 -0.46 1034410.0 -31501.5625 -0.17342555002994 -0.5202 -0.9312 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 H24 mock treatment 955040.0 -15900.0 -0.09 872720.0 -49500.0 -0.25 1210560.0 144648.4375 0.796333033779165 0.2645 0.3153 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I01 compound treatment 1158050.0 187000.0 1.07 1023610.0 101000.0 0.51 1081870.0 15958.4375 0.0878559849549027 0.9607 0.8098 2072948 Maybridge1_006689 Cc1ccc(cc1)S(=O)(=O)Oc2ccc(C)cc2Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I02 compound treatment 866340.0 -105000.0 -0.6 820920.0 -101000.0 -0.51 804480.0 -261431.5625 -1.43925916442238 -1.4683 -0.8961 2072949 Maybridge1_006690 Cc1cnc2CCCC(=O)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I03 compound treatment 804070.0 -167000.0 -0.95 716970.0 -205000.0 -1.03 822420.0 -243491.5625 -1.34049408356211 -1.9169 -0.9887 1290694 Maybridge1_006691 COc1ccccc1C2CCN(CC2)C(=O)c3ccc(F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I04 compound treatment 815090.0 -156000.0 -0.89 736800.0 -185000.0 -0.93 942170.0 -123741.5625 -0.681234416169889 -1.4426 -0.9917 2072950 Maybridge1_006692 COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CN3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I05 compound treatment 771420.0 -200000.0 -1.14 702840.0 -219000.0 -1.1 794720.0 -271191.5625 -1.49299089180232 -2.1534 -0.99 1611583 Maybridge1_006693 COc1ccccc1C2CCN(CC2)C(=O)c3ccccc3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I06 compound treatment 792640.0 -178000.0 -1.02 690240.0 -232000.0 -1.16 794140.0 -271771.5625 -1.49618396576547 -2.1216 -0.9869 2072951 Maybridge1_006694 CCc1cc2c(cc1C(=O)CSc3nnc(COc4ccc(C)c5CCCc54)n3c6ccccc6)C(C)(C)CCC2(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I07 compound treatment 787470.0 -183000.0 -1.05 647450.0 -275000.0 -1.37 716680.0 -349231.5625 -1.9226244988444 -2.5085 -0.9703 2072952 Maybridge1_006695 Fc1ccc(CCc2ccc(F)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I08 compound treatment 807160.0 -164000.0 -0.94 706670.0 -216000.0 -1.08 851230.0 -214681.5625 -1.18188639239243 -1.8449 -0.9955 2072953 Maybridge1_006696 Cc1ccc(OCc2nnc(SCC(=O)c3ccc(F)cc3)n2c4ccccc4)c5CCCc51 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I09 compound treatment 897410.0 -73500.0 -0.42 718300.0 -204000.0 -1.02 900610.0 -165301.5625 -0.910034681529562 -1.3567 -0.9488 1226641 Maybridge1_006697 O=C1CCCc2nc3CCCC(=O)c3cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I10 compound treatment 860960.0 -110000.0 -0.63 708960.0 -213000.0 -1.07 871360.0 -194551.5625 -1.0710647046713 -1.5968 -0.9755 1616269 Maybridge1_006698 Cc1ccc(C)c2c(O)c(cnc12)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I11 compound treatment 872000.0 -98900.0 -0.57 753060.0 -169000.0 -0.85 857720.0 -208191.5625 -1.14615699580474 -1.4764 -0.9634 1571873 Maybridge1_006699 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccc(C)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I12 compound treatment 854770.0 -116000.0 -0.66 936990.0 14800.0 0.07 1132100.0 66188.4375 0.364387200763767 -0.13 -0.1709 2072954 Maybridge1_006700 COc1ccc(cc1)C(=O)c2cc3cc(ccc3o2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I13 compound treatment 867560.0 -103000.0 -0.59 732510.0 -190000.0 -0.95 859390.0 -206521.5625 -1.13696314491084 -1.5451 -0.9692 2072955 Maybridge1_006701 Fc1ccc(cc1)C(=O)NNC(=O)CSCc2cccc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I14 compound treatment 518520.0 -452000.0 -2.58 560410.0 -362000.0 -1.81 658250.0 -407661.5625 -2.24429917413231 -3.8325 -0.9899 1342049 Maybridge1_006702 Clc1cc(Cl)c2oc(cc2c1)C(=O)c3ccc(Br)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I15 compound treatment 40590.0 -930000.0 -5.31 33640.0 -889000.0 -4.44 31540.0 -1034371.5625 -5.69452569731712 -8.9219 -0.9949 2072956 Maybridge1_006703 Cc1nnc(Sc2ccc([N+](=O)[O-])c(Sc3nnc(C)s3)n2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I16 compound treatment 936930.0 -34000.0 -0.19 756130.0 -166000.0 -0.83 1084130.0 18218.4375 0.100297962811324 -0.5338 -0.6215 2072957 Maybridge1_006704 [O-][N+](=O)c1cc(Cl)c(cc1SCc2ccc(Cl)cc2Cl)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I17 compound treatment 892420.0 -78500.0 -0.45 740270.0 -182000.0 -0.91 962150.0 -103761.5625 -0.571238523439228 -1.1141 -0.9569 1731945 Maybridge1_006705 COc1cc(CCC(C)N)ccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I18 compound treatment 817220.0 -154000.0 -0.88 662850.0 -259000.0 -1.3 801700.0 -264211.5625 -1.45456389824576 -2.0956 -0.9804 2072958 Maybridge1_006706 OC(c1cc2cc(ccc2o1)[N+](=O)[O-])c3ccc(cc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I19 compound treatment 879040.0 -91900.0 -0.52 742990.0 -179000.0 -0.9 899920.0 -165991.5625 -0.913833338485726 -1.3481 -0.9745 1682780 Maybridge1_006707 CCOC(=O)c1c[nH]c2ccccc2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I20 compound treatment 867880.0 -103000.0 -0.59 755040.0 -167000.0 -0.84 875940.0 -189971.5625 -1.04585043096226 -1.4264 -0.9752 2072959 Maybridge1_006708 OS(=O)(=O)c1ccc(Nc2ncnc3ccccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I21 compound treatment 719320.0 -252000.0 -1.44 673220.0 -249000.0 -1.25 764280.0 -301631.5625 -1.66057222186845 -2.5075 -0.9932 2072960 Maybridge1_006709 CCCCc1ccc(NC(=S)NNC(=O)CSCc2cccc3ccccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I22 compound treatment 885050.0 -85900.0 -0.49 758580.0 -164000.0 -0.82 889700.0 -176211.5625 -0.970097503836444 -1.3158 -0.967 1020457 Maybridge1_006710 OC(=O)c1ccccc1C(=O)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I23 mock treatment 938050.0 -32900.0 -0.19 784290.0 -138000.0 -0.69 964990.0 -100921.5625 -0.555603471619654 -0.8274 -0.9139 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 I24 mock treatment 924440.0 -46500.0 -0.27 836510.0 -85700.0 -0.43 1180530.0 114618.4375 0.631008876686985 -0.0364 -0.0451 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J01 compound treatment 904170.0 -66800.0 -0.38 928370.0 6170.0 0.03 847290.0 -218621.5625 -1.20357727414212 -0.8972 -0.7104 1719291 Maybridge1_006711 COc1cc(Br)cc2cc(C(=O)O)c(=O)oc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J02 compound treatment 690260.0 -281000.0 -1.6 637390.0 -285000.0 -1.42 747110.0 -318801.5625 -1.75509822177763 -2.7614 -0.9964 2072961 Maybridge1_006712 FC(F)(F)c1cc(nc(OCC(=O)c2ccc(Cl)cc2)c1C#N)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J03 compound treatment 766350.0 -205000.0 -1.17 698360.0 -224000.0 -1.12 764850.0 -301061.5625 -1.65743420090466 -2.278 -0.9834 2072962 Maybridge1_006713 CC(=O)OCc1cc(/C=N/N(C(=O)C)c2ccccc2)nn1c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J04 compound treatment 588020.0 -383000.0 -2.19 557290.0 -365000.0 -1.83 768960.0 -296951.5625 -1.63480741816577 -3.2604 -0.9927 1464724 Maybridge1_006714 COc1ccc(cc1)C(=O)COc2ccc(C)cc2NC(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J05 compound treatment 805320.0 -166000.0 -0.95 634340.0 -288000.0 -1.44 788010.0 -277901.5625 -1.52993145437603 -2.2607 -0.9812 2072963 Maybridge1_006715 CC(=O)C(=NNc1ccc(C)cc1[N+](=O)[O-])C(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J06 compound treatment 601640.0 -369000.0 -2.11 526520.0 -396000.0 -1.98 555810.0 -510101.5625 -2.80826209962425 -3.9819 -0.9877 1626134 Maybridge1_006716 Cc1ccc2cc(NC(=O)c3ccco3)ccc2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J07 compound treatment 804380.0 -167000.0 -0.95 727130.0 -195000.0 -0.98 875400.0 -190511.5625 -1.04882329292796 -1.7181 -0.9991 2072964 Maybridge1_006717 [O-][N+](=O)c1cc(ccc1NCCNC(=O)c2cccnc2Oc3ccccc3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J08 compound treatment 829180.0 -142000.0 -0.81 708340.0 -214000.0 -1.07 809870.0 -256041.5625 -1.40958559776481 -1.8989 -0.9758 2072965 Maybridge1_006718 [O-][N+](=O)c1ccc(o1)c2nnc(S)o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J09 compound treatment 825190.0 -146000.0 -0.83 665170.0 -257000.0 -1.29 890730.0 -175181.5625 -0.964427044901881 -1.7797 -0.9833 1362612 Maybridge1_006719 Clc1ccc(Oc2ncccc2NC(=O)c3cccc4ccccc34)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J10 compound treatment 890780.0 -80100.0 -0.46 746290.0 -176000.0 -0.88 904770.0 -161141.5625 -0.887132633793849 -1.2845 -0.9653 2072966 Maybridge1_006720 OC(=O)C1CC1(Cl)Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J11 compound treatment 765010.0 -206000.0 -1.18 625820.0 -296000.0 -1.48 784390.0 -281521.5625 -1.54986064014605 -2.4298 -0.9934 2072967 Maybridge1_006721 Cc1ccc(C)n1c2ccc(cc2)C(=O)NNC(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J12 compound treatment 813600.0 -157000.0 -0.9 758250.0 -164000.0 -0.82 1147580.0 81668.4375 0.449609243780315 -0.7327 -0.5649 2072968 Maybridge1_006722 OC1(CCN(Cc2ccccc2)CC1)C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J13 compound treatment 867060.0 -104000.0 -0.59 1010130.0 87900.0 0.44 1270770.0 204858.4375 1.12780714295399 0.5625 0.4172 2072969 Maybridge1_006723 CCCCCc1ccc(cc1)S(=O)(=O)Nc2cccnc2Oc3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J14 compound treatment 818430.0 -152000.0 -0.87 763110.0 -159000.0 -0.8 935260.0 -130651.5625 -0.719276038730893 -1.3776 -0.997 1060930 Maybridge1_006724 CCCC(NC(=O)CN)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J15 compound treatment 871650.0 -99300.0 -0.57 711240.0 -211000.0 -1.06 850370.0 -215541.5625 -1.18662095033779 -1.6217 -0.9618 1319787 Maybridge1_006725 Cc1ccc(C)n1c2cccnc2Sc3ccc(C)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J16 compound treatment 846720.0 -124000.0 -0.71 675280.0 -247000.0 -1.23 904060.0 -161851.5625 -0.891041396748742 -1.6371 -0.9744 1320822 Maybridge1_006726 Clc1ccc(cc1)C2C(=O)c3ccccc3C2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J17 compound treatment 870470.0 -100000.0 -0.57 774400.0 -148000.0 -0.74 914050.0 -151861.5625 -0.836043450383411 -1.2408 -0.9888 2072970 Maybridge1_006727 COc1ccc(cc1)C(=O)Cn2cc(nc2C)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J18 compound treatment 906080.0 -64800.0 -0.37 864480.0 -57700.0 -0.29 1129220.0 63308.4375 0.348531936946734 -0.1793 -0.3066 1369467 Maybridge1_006728 COC(=O)CCC1CC2(CCC1=O)OCCO2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J19 compound treatment 863100.0 -108000.0 -0.62 720530.0 -202000.0 -1.01 884930.0 -180981.5625 -0.996357784533404 -1.5132 -0.9789 2072971 Maybridge1_006729 CCOC(=O)COc1nc(C)cc(c1C#N)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J20 compound treatment 819050.0 -152000.0 -0.87 680690.0 -242000.0 -1.21 874720.0 -191191.5625 -1.05256689688476 -1.806 -0.9912 1331647 Maybridge1_006730 CC1(C)C2CCC1(C)C(C2)NC(=O)c3ccc(Cl)cc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J21 compound treatment 997450.0 26500.0 0.15 724970.0 -197000.0 -0.99 905280.0 -160631.5625 -0.884324930826249 -0.9926 -0.7444 2072972 Maybridge1_006731 Nc1nnc(SCCCCOC2CCCCO2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J22 compound treatment 847750.0 -123000.0 -0.7 794460.0 -128000.0 -0.64 1206610.0 140698.4375 0.77458709903011 -0.3279 -0.2674 2072973 Maybridge1_006732 Cc1cc2-c3nonc3CCc2nn1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J23 mock treatment 948520.0 -22400.0 -0.13 850790.0 -71400.0 -0.36 954020.0 -111891.5625 -0.615996611922725 -0.6357 -0.8788 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 J24 mock treatment 957570.0 -13400.0 -0.08 869540.0 -52700.0 -0.26 1243490.0 177578.4375 0.977622560687106 0.3683 0.3628 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K01 compound treatment 1007840.0 36900.0 0.21 816980.0 -105000.0 -0.53 983940.0 -81971.5625 -0.451278037823557 -0.4426 -0.6109 2072974 Maybridge1_006733 COc1ccc(OS(=O)(=O)c2ccc(C)cc2)c(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K02 compound treatment 817510.0 -153000.0 -0.88 862780.0 -59400.0 -0.3 827060.0 -238851.5625 -1.31494949185689 -1.4367 -0.8935 1205178 Maybridge1_006734 N#Cc1ccc2[nH]cc(CCN(Cc3ccccc3)Cc4ccccc4)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K03 compound treatment 797190.0 -174000.0 -0.99 731840.0 -190000.0 -0.95 808750.0 -257161.5625 -1.41575153369365 -1.9401 -0.9829 1727215 Maybridge1_006735 COc1ccccc1C2CCN(CC2)C(=O)c3ccccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K04 compound treatment 39770.0 -931000.0 -5.32 40060.0 -882000.0 -4.41 41450.0 -1024461.5625 -5.63996817494671 -8.8746 -0.9949 2072975 Maybridge1_006736 [O-][N+](=O)/C=C/c1ccc2OCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K05 compound treatment 802600.0 -168000.0 -0.96 702320.0 -220000.0 -1.1 898240.0 -167671.5625 -0.923082242378995 -1.723 -0.9971 2072976 Maybridge1_006737 COC(=O)C1Cc2c([nH]c3ccccc23)C4(CCN(C)CC4)N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K06 compound treatment 857120.0 -114000.0 -0.65 914660.0 -7540.0 -0.04 920670.0 -145241.5625 -0.799598364803983 -0.8588 -0.8328 2072977 Maybridge1_006738 Cc1ccc(OCc2nnc(SCC(=O)NCc3ccccc3)n2c4ccccc4)c5CCCc51 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K07 compound treatment 854430.0 -116000.0 -0.67 780880.0 -141000.0 -0.71 896240.0 -169671.5625 -0.934092842251933 -1.3316 -0.9884 2072949 Maybridge1_006739 Cc1cnc2CCCC(=O)c2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K08 compound treatment 502430.0 -468000.0 -2.68 462880.0 -459000.0 -2.3 507710.0 -558201.5625 -3.07306702656843 -4.6457 -0.9931 2072978 Maybridge1_006740 Cc1ccc(OCc2nnc(SCC(=O)c3ccccc3)n2c4ccccc4)c5CCCc51 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K09 compound treatment 762050.0 -209000.0 -1.19 640370.0 -282000.0 -1.41 744020.0 -321891.5625 -1.77210959858132 -2.5258 -0.9869 1702857 Maybridge1_006741 Cc1cccc(NC(=O)c2cccc3ccccc23)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K10 compound treatment 879540.0 -91400.0 -0.52 734150.0 -188000.0 -0.94 889290.0 -176621.5625 -0.972354676810397 -1.4058 -0.9695 2072979 Maybridge1_006742 [O-][N+](=O)c1ccc2oc(cc2c1)C(=O)c3ccc(cc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K11 compound treatment 915940.0 -55000.0 -0.31 855910.0 -66300.0 -0.33 1095140.0 29228.4375 0.160911315111853 -0.2799 -0.578 1540037 Maybridge1_006743 COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c3ccccc3Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K12 compound treatment 884860.0 -86100.0 -0.49 710610.0 -212000.0 -1.06 926020.0 -139891.5625 -0.770145010143871 -1.3395 -0.9581 2072980 Maybridge1_006744 COc1cc(NC(=O)C)cc(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K13 compound treatment 884220.0 -86700.0 -0.5 745890.0 -176000.0 -0.88 916510.0 -149401.5625 -0.822500412539696 -1.27 -0.9742 2072981 Maybridge1_006745 COC(=O)C(Cc1c[nH]c2ccccc12)/N=C/c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K14 compound treatment 658500.0 -312000.0 -1.78 589830.0 -332000.0 -1.66 663420.0 -402491.5625 -2.21583677346077 -3.2695 -0.9922 1427936 Maybridge1_006746 Fc1ccc(cc1)C(=O)c2cc3cc(Cl)cc(Cl)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K15 compound treatment 880480.0 -90400.0 -0.52 719700.0 -202000.0 -1.01 922420.0 -143491.5625 -0.789964089915162 -1.3391 -0.9672 1705365 Maybridge1_006747 CN1CCCC21NCCc3c2[nH]c4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K16 compound treatment 854000.0 -117000.0 -0.67 731430.0 -191000.0 -0.95 909630.0 -156281.5625 -0.860376876102607 -1.4332 -0.9898 1024400 Maybridge1_006748 COC(=O)C(N)Cc1c[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K17 compound treatment 850400.0 -121000.0 -0.69 706510.0 -216000.0 -1.08 929280.0 -136631.5625 -0.752197732350981 -1.4546 -0.9799 2072982 Maybridge1_006749 O/N=C/1\CCCc2[nH]c3ccccc3c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K18 compound treatment 730050.0 -241000.0 -1.38 607400.0 -315000.0 -1.57 751570.0 -314341.5625 -1.73054458406098 -2.7026 -0.9957 2072983 Maybridge1_006750 OC(c1cc2cc(ccc2o1)[N+](=O)[O-])c3ccc(F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K19 compound treatment 777320.0 -194000.0 -1.11 680890.0 -241000.0 -1.21 830160.0 -235751.5625 -1.29788306205384 -2.0847 -0.9979 1554526 Maybridge1_006751 Brc1cnc(nc1)N2CCNCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K20 compound treatment 916850.0 -54100.0 -0.31 802200.0 -120000.0 -0.6 971760.0 -94151.5625 -0.518332591049756 -0.8241 -0.9683 2072984 Maybridge1_006752 Cc1ccc(N/N=C\2/CCCNC2=O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K21 compound treatment 786100.0 -185000.0 -1.06 661970.0 -260000.0 -1.3 779520.0 -286391.5625 -1.57667145083666 -2.2713 -0.9871 2072985 Maybridge1_006753 O=C(CSCc1cccc2ccccc12)NNC(=S)NC3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K22 compound treatment 840020.0 -131000.0 -0.75 775420.0 -147000.0 -0.73 936550.0 -129361.5625 -0.712174201812847 -1.2668 -0.9998 1324807 Maybridge1_006754 O=C(C1CCCCC1)N2CCNCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K23 mock treatment 975910.0 4980.0 0.03 843650.0 -78500.0 -0.39 956640.0 -109271.5625 -0.601572726089175 -0.5577 -0.7756 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 K24 mock treatment 1038370.0 67400.0 0.39 973280.0 51100.0 0.26 1227460.0 161548.4375 0.8893726027055 0.8834 0.8814 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L01 compound treatment 1170090.0 199000.0 1.14 908520.0 -13700.0 -0.07 1034090.0 -31821.5625 -0.175187246009611 0.5162 0.4477 1004718 Maybridge1_006755 OC(=O)Cc1c[nH]c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L02 compound treatment 854400.0 -117000.0 -0.67 702170.0 -220000.0 -1.1 857470.0 -208441.5625 -1.14753332078886 -1.6822 -0.976 2072986 Maybridge1_006756 COc1ccc(cc1)C(=O)COc2nc(cc(c2C#N)C(F)(F)F)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L03 compound treatment 803890.0 -167000.0 -0.95 793650.0 -129000.0 -0.64 996980.0 -68931.5625 -0.379488926651994 -1.1412 -0.9419 1921262 Maybridge1_006757 O=C(NNC(=O)c1ccccc1)Nc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L04 compound treatment 699550.0 -271000.0 -1.55 628010.0 -294000.0 -1.47 714360.0 -351551.5625 -1.93539679469701 -2.8619 -0.9926 2072987 Maybridge1_006758 COc1ccc(C=C2C(=O)OC(C)(C)OC2=O)c(Cl)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L05 compound treatment 833650.0 -137000.0 -0.78 665290.0 -257000.0 -1.28 741620.0 -324291.5625 -1.78532231842885 -2.2254 -0.9529 2072988 Maybridge1_006759 [O-][N+](=O)c1cc(ccc1NCCNS(=O)(=O)c2ccc3ccccc3c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L06 compound treatment 678040.0 -293000.0 -1.67 596080.0 -326000.0 -1.63 711170.0 -354741.5625 -1.95295870149435 -3.0352 -0.9967 1687379 Maybridge1_006760 Cc1ccc2cc(NC(=O)c3cccs3)ccc2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L07 compound treatment 708900.0 -262000.0 -1.5 736490.0 -186000.0 -0.93 934500.0 -131411.5625 -0.72346006668261 -1.8181 -0.9547 2072989 Maybridge1_006761 CCCc1ccc(cc1)C(=O)NNC(=O)c2ccc(cc2)n3c(C)ccc3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L08 compound treatment 544370.0 -427000.0 -2.44 572240.0 -350000.0 -1.75 630200.0 -435711.5625 -2.39872283735028 -3.8023 -0.9899 2072990 Maybridge1_006762 Sc1nnc2nc(c3ccccc3)c(nn12)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L09 compound treatment 767850.0 -203000.0 -1.16 674480.0 -248000.0 -1.24 792000.0 -273911.5625 -1.50796530762952 -2.2557 -0.9935 1360230 Maybridge1_006763 CC(C)(C)c1ccc(Oc2ncccc2NC(=O)c3ccco3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L10 compound treatment 811160.0 -160000.0 -0.91 662560.0 -260000.0 -1.3 924000.0 -141911.5625 -0.78126571601554 -1.7277 -0.9766 2072991 Maybridge1_006764 CC(=O)c1ccc(cc1)C2CC2(Cl)Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L11 compound treatment 817940.0 -153000.0 -0.87 738490.0 -184000.0 -0.92 1028850.0 -37061.5625 -0.204035017676711 -1.1529 -0.8976 1505726 Maybridge1_006765 CC(C)(C)OC(=O)C(C)(C)Sc1nnc(N)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L12 compound treatment 845980.0 -125000.0 -0.71 761360.0 -161000.0 -0.8 868960.0 -196951.5625 -1.08427742451882 -1.5025 -0.9839 1005800 Maybridge1_006766 Cc1ccc2cccc(Cl)c2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L13 compound treatment 1013350.0 42400.0 0.24 899680.0 -22500.0 -0.11 1195550.0 129638.4375 0.713698481732757 0.4869 0.639 2072992 Maybridge1_006767 NC(=O)c1ccccc1NC(=O)c2cccs2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L14 compound treatment 908400.0 -62500.0 -0.36 950980.0 28800.0 0.14 953980.0 -111931.5625 -0.616216823920184 -0.4789 -0.659 1050132 Maybridge1_006768 NCC(=O)NC(Cc1ccccc1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L15 compound treatment 630080.0 -341000.0 -1.95 485140.0 -437000.0 -2.19 557340.0 -508571.5625 -2.79983899072145 -4.0027 -0.9881 1424974 Maybridge1_006769 CCOC(=O)c1ccc2nc(cc(O)c2c1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L16 compound treatment 920200.0 -50700.0 -0.29 731950.0 -190000.0 -0.95 884360.0 -181551.5625 -0.999495805497191 -1.2937 -0.9175 2072993 Maybridge1_006770 OC1=C(C(=O)c2ccccc12)c3ccc(Br)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L17 compound treatment 613890.0 -357000.0 -2.04 527290.0 -395000.0 -1.98 648110.0 -417801.5625 -2.30012291548811 -3.6459 -0.9978 1433410 Maybridge1_006771 Cc1cc(N2CCNCC2)c3ccccc3n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L18 compound treatment 901470.0 -69500.0 -0.4 722800.0 -199000.0 -1.0 880390.0 -185521.5625 -1.02135184624498 -1.3945 -0.9412 2072994 Maybridge1_006772 CC(Nc1ccccc1)C2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L19 compound treatment 875410.0 -95500.0 -0.55 857830.0 -64400.0 -0.32 1191540.0 125628.4375 0.691622228987515 -0.1016 -0.1083 2072995 Maybridge1_006773 COc1cccc(c1)c2nnc(o2)c3ccccc3NC(=O)c4ccc(F)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L20 compound treatment 824800.0 -146000.0 -0.83 675290.0 -247000.0 -1.23 820270.0 -245641.5625 -1.35233047842552 -1.9757 -0.9817 1406897 Maybridge1_006774 CC(C)(C)c1ccc(cc1)C(=O)NC2CC3CCC2(C)C3(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L21 compound treatment 870720.0 -100000.0 -0.57 706610.0 -216000.0 -1.08 973960.0 -91951.5625 -0.506220931189523 -1.2453 -0.9423 2072996 Maybridge1_006775 CC(O)c1sc(nc1C)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L22 compound treatment 736720.0 -234000.0 -1.34 748740.0 -173000.0 -0.87 879700.0 -186211.5625 -1.02515050320114 -1.8652 -0.9839 1614912 Maybridge1_006776 C1Cc2nnc(cc2-c3nonc13)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L23 mock treatment 989120.0 18200.0 0.1 813690.0 -109000.0 -0.54 889820.0 -176091.5625 -0.969436867844068 -0.813 -0.7286 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 L24 mock treatment 974080.0 3150.0 0.02 1036490.0 114000.0 0.57 1107450.0 41538.4375 0.228681557329793 0.4725 0.7671 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M01 compound treatment 1038270.0 67300.0 0.38 955040.0 32800.0 0.16 1031900.0 -34011.5625 -0.187243852870479 0.2088 0.4557 2072997 Maybridge1_006777 COS(=O)(=O)c1ccc2C(=O)CC(C)(C)Oc2c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M02 compound treatment 535300.0 -436000.0 -2.49 639260.0 -283000.0 -1.42 537940.0 -527971.5625 -2.90664180948896 -3.9319 -0.9638 2072998 Maybridge1_006778 FC(F)(F)Oc1ccc(cc1)n2c(S)nnc2CSCc3cccc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M03 compound treatment 872380.0 -98500.0 -0.56 646400.0 -276000.0 -1.38 735890.0 -330021.5625 -1.81686768706482 -2.1704 -0.9237 1048869 Maybridge1_006779 Cc1cc(OCc2ccccc2)ccc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M04 compound treatment 765880.0 -205000.0 -1.17 792220.0 -130000.0 -0.65 838300.0 -227611.5625 -1.25306992057098 -1.7751 -0.9677 2072999 Maybridge1_006780 CC1=NN(C(=O)C1)c2ccc(F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M05 compound treatment 797830.0 -173000.0 -0.99 771810.0 -150000.0 -0.75 785380.0 -280531.5625 -1.54441039320894 -1.8968 -0.957 2073000 Maybridge1_006781 CCOC(CN(Cc1ccc(OC)c(OS(=O)(=O)c2ccc(C)cc2)c1)S(=O)(=O)c3ccc(C)cc3)OCC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M06 compound treatment 554690.0 -416000.0 -2.38 469410.0 -453000.0 -2.26 505370.0 -560541.5625 -3.08594942841977 -4.462 -0.9902 2073001 Maybridge1_006782 Cc1ccc(OCc2nnc(SCC(=O)Nc3cccc(c3)C(F)(F)F)n2c4ccccc4)c5CCCc51 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M07 compound treatment 861010.0 -110000.0 -0.63 755840.0 -166000.0 -0.83 962430.0 -103481.5625 -0.569697039457016 -1.1718 -0.9865 1287839 Maybridge1_006783 CN1C2CCC1CC(=NO)C2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M08 compound treatment 830790.0 -140000.0 -0.8 720040.0 -202000.0 -1.01 845520.0 -220391.5625 -1.21332165502967 -1.7465 -0.9863 2073002 Maybridge1_006784 CSc1nnc(COc2ccc(C)c3CCCc32)n1c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M09 compound treatment 836400.0 -135000.0 -0.77 707060.0 -215000.0 -1.08 883850.0 -182061.5625 -1.00230350846479 -1.6436 -0.9906 1652203 Maybridge1_006785 Fc1ccc(CN2CCC(CC2)NC(=O)c3ccccc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M10 compound treatment 836070.0 -135000.0 -0.77 711710.0 -210000.0 -1.05 830010.0 -235901.5625 -1.29870885704431 -1.8024 -0.9792 2073003 Maybridge1_006786 [O-][N+](=O)c1ccc2oc(cc2c1)C(=O)c3ccc(OC(F)(F)F)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M11 compound treatment 1003050.0 32100.0 0.18 747290.0 -175000.0 -0.87 945970.0 -119941.5625 -0.660314276411304 -0.7804 -0.7022 1134551 Maybridge1_006787 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccc(OC)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M12 compound treatment 847870.0 -123000.0 -0.7 905890.0 -16300.0 -0.08 1019420.0 -46491.5625 -0.255949996077619 -0.6007 -0.7983 2073004 Maybridge1_006788 [O-][N+](=O)c1cccc(c1)C(=O)c2cc3cc(Br)cc(Br)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M13 compound treatment 1107770.0 137000.0 0.78 731060.0 -191000.0 -0.96 862150.0 -203761.5625 -1.12176851708618 -0.7483 -0.4485 2073005 Maybridge1_006789 CC/1(C)C2CC[C@](C)(C2)\C1=N\O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M14 compound treatment 694200.0 -277000.0 -1.58 642240.0 -280000.0 -1.4 729370.0 -336541.5625 -1.8527622426506 -2.7908 -0.9934 1223857 Maybridge1_006790 Clc1ccc(cc1)C(=O)c2cc3cc(Cl)cc(Cl)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M15 compound treatment 745450.0 -225000.0 -1.29 689020.0 -233000.0 -1.17 802140.0 -263771.5625 -1.45214156627371 -2.2554 -0.996 1337456 Maybridge1_006791 CC(C)(C)NC(=O)N1CCN(CC1)c2ncnc3scc(c4ccccc4)c23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M16 compound treatment 965820.0 -5110.0 -0.03 861640.0 -60600.0 -0.3 1178940.0 113028.4375 0.622255449787999 0.1675 0.2419 2073006 Maybridge1_006792 [O-][N+](=O)c1cc(Cl)c(cc1SCc2ccc(Cl)c(Cl)c2)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M17 compound treatment 931720.0 -39200.0 -0.22 754820.0 -167000.0 -0.84 871930.0 -193981.5625 -1.06792668370751 -1.2292 -0.8938 1427039 Maybridge1_006793 COc1ccccc1N2CCN(CC2)C(=O)c3ccc(N)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M18 compound treatment 629180.0 -342000.0 -1.95 594430.0 -328000.0 -1.64 599680.0 -466231.5625 -2.56674459141133 -3.5555 -0.9828 2073007 Maybridge1_006794 CCOC(=O)c1ccc(cc1)n2c(C)ccc2C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M19 compound treatment 872800.0 -98100.0 -0.56 753150.0 -169000.0 -0.85 898740.0 -167171.5625 -0.92032959241076 -1.3431 -0.9806 2073008 Maybridge1_006795 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccc(Oc4c(Cl)cccc4[N+](=O)[O-])cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M20 compound treatment 901980.0 -68900.0 -0.39 728160.0 -194000.0 -0.97 898420.0 -167491.5625 -0.92209128839043 -1.3201 -0.946 1248044 Maybridge1_006796 CC(Nc1ccccn1)C(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M21 compound treatment 839400.0 -132000.0 -0.75 705290.0 -217000.0 -1.08 914440.0 -151471.5625 -0.833896383408188 -1.5416 -0.9875 1364670 Maybridge1_006797 COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c3cccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M22 compound treatment 847450.0 -123000.0 -0.71 785360.0 -137000.0 -0.68 913120.0 -152791.5625 -0.841163379324328 -1.288 -0.9957 1495828 Maybridge1_006798 O=C1N(CCC#N)c2ccccc2C31OCCO3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M23 mock treatment 910180.0 -60700.0 -0.35 837060.0 -85100.0 -0.43 936760.0 -129151.5625 -0.711018088826189 -0.8567 -0.9535 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 M24 mock treatment 981860.0 10900.0 0.06 910200.0 -12000.0 -0.06 1128750.0 62838.4375 0.345944445976594 0.2011 0.564 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N01 compound treatment 984280.0 13400.0 0.08 867390.0 -54800.0 -0.27 750200.0 -315711.5625 -1.73808684497394 -1.1177 -0.6346 2073009 Maybridge1_006799 CC(=O)c1ccc(Nc2ccnc3cc(Cl)ccc23)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N02 compound treatment 893230.0 -77700.0 -0.44 776640.0 -146000.0 -0.73 985480.0 -80431.5625 -0.442799875921394 -0.9322 -0.9703 2073010 Maybridge1_006800 Cc1c(sc2ccc(Cl)cc12)C(=O)COc3nc(cc(c3C#N)C(F)(F)F)c4cccs4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N03 compound treatment 830990.0 -140000.0 -0.8 798960.0 -123000.0 -0.62 966080.0 -99831.5625 -0.549602694688903 -1.1347 -0.9873 2073011 Maybridge1_006801 Cc1ccc(C)n1c2ccc(cc2)c3nnc(S)n3c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N04 compound treatment 820160.0 -151000.0 -0.86 799880.0 -122000.0 -0.61 881600.0 -184311.5625 -1.01469043332185 -1.4363 -0.9805 1218710 Maybridge1_006802 Cc1c(oc2ccc3ccccc3c12)C(=O)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N05 compound treatment 768220.0 -203000.0 -1.16 808330.0 -114000.0 -0.57 905400.0 -160511.5625 -0.883664294833873 -1.5075 -0.9639 2073012 Maybridge1_006803 CC(=O)Nc1ccc(cc1)S(=O)(=O)NCCNc2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N06 compound treatment 841220.0 -130000.0 -0.74 790510.0 -132000.0 -0.66 863630.0 -202281.5625 -1.1136206731802 -1.451 -0.9732 1505499 Maybridge1_006804 OC(=O)c1cc2c(Cl)cc(Cl)cc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N07 compound treatment 982890.0 12000.0 0.07 902680.0 -19500.0 -0.1 1107600.0 41688.4375 0.229507352320263 0.1156 0.447 1384754 Maybridge1_006805 CCCc1ccc(cc1)C(=O)Nc2cccnc2Oc3ccc(Cl)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N08 compound treatment 970270.0 -655.0 0.0 788000.0 -134000.0 -0.67 901280.0 -164631.5625 -0.906346130572127 -0.913 -0.8095 2073013 Maybridge1_006806 CCSC(SCC)[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)CO 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N09 compound treatment 908580.0 -62300.0 -0.36 828730.0 -93500.0 -0.47 923860.0 -142051.5625 -0.782036458006645 -0.927 -0.9476 1138325 Maybridge1_006807 CCCc1ccc(cc1)C(=O)Nc2cccnc2Oc3ccc(OC)cc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N10 compound treatment 627410.0 -344000.0 -1.96 620500.0 -302000.0 -1.51 728000.0 -337911.5625 -1.86030450356356 -3.0782 -0.9941 1187040 Maybridge1_006808 C(c1nc2ccccc2s1)c3nc4ccccc4s3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N11 compound treatment 849600.0 -121000.0 -0.69 691200.0 -231000.0 -1.16 953640.0 -112271.5625 -0.618088625898583 -1.424 -0.9607 1051542 Maybridge1_006809 CC1(CC2CC1C=C2)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N12 compound treatment 803100.0 -168000.0 -0.96 823970.0 -98200.0 -0.49 983840.0 -82071.5625 -0.451828567817204 -1.098 -0.9399 864479 Maybridge1_006810 COc1cc(CC(N)C(=O)O)ccc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N13 compound treatment 925000.0 -45900.0 -0.26 819220.0 -103000.0 -0.52 1090320.0 24408.4375 0.13437576941807 -0.3713 -0.6256 1194173 Maybridge1_006811 CC(C)(C)c1ccc(Oc2ncccc2NC(=O)c3cccc4ccccc34)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N14 compound treatment 918880.0 -52000.0 -0.3 858440.0 -63800.0 -0.32 957600.0 -108311.5625 -0.596287638150164 -0.7 -0.9477 2073014 Maybridge1_006812 NCC(=O)NCC(=O)NCC(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N15 compound treatment 882760.0 -88200.0 -0.5 832560.0 -89600.0 -0.45 981610.0 -84301.5625 -0.464105386675531 -0.8176 -0.9988 2073015 Maybridge1_006813 [O-][N+](=O)c1cc(Cl)c(cc1Sc2nc(c(o2)c3ccccc3)c4ccccc4)n5cccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N16 compound treatment 301550.0 -669000.0 -3.82 252320.0 -670000.0 -3.35 249440.0 -816471.5625 -4.49492084116042 -6.7372 -0.9928 2073016 Maybridge1_006814 OC1=C(C(=O)c2ccccc12)c3ccc(cc3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N17 compound treatment 850490.0 -120000.0 -0.69 699050.0 -223000.0 -1.12 868540.0 -197371.5625 -1.08658965049214 -1.6689 -0.9801 1375532 Maybridge1_006815 Nn1c(cc(c(C#N)c1=O)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N18 compound treatment 877640.0 -93300.0 -0.53 796010.0 -126000.0 -0.63 941050.0 -124861.5625 -0.687400352098735 -1.0689 -0.9947 1477161 Maybridge1_006816 COc1ccccc1N2CCN(CC2)C(=O)C(C)Nc3ccccn3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N19 compound treatment 986190.0 15300.0 0.09 724370.0 -198000.0 -0.99 809510.0 -256401.5625 -1.41156750574193 -1.3359 -0.774 2073017 Maybridge1_006817 Fc1ccc(cc1)C(=O)Nc2ccccc2c3nnc(o3)c4ccc(Cl)cc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N20 compound treatment 820640.0 -150000.0 -0.86 704450.0 -218000.0 -1.09 850760.0 -215151.5625 -1.18447388336257 -1.8083 -0.9915 1368775 Maybridge1_006818 CC1(C)C2CCC1(C)C(C2)NC(=O)C3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N21 compound treatment 816180.0 -155000.0 -0.88 724430.0 -198000.0 -0.99 938400.0 -127511.5625 -0.701989396930379 -1.4867 -0.9906 1177559 Maybridge1_006819 CCN(CC)c1ccc2cc(C(=O)O)c(=O)oc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N22 compound treatment 833310.0 -138000.0 -0.79 739170.0 -183000.0 -0.92 892840.0 -173071.5625 -0.95281086203593 -1.5325 -0.9968 2073018 Maybridge1_006820 Cc1cc(cnn1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N23 mock treatment 887490.0 -83400.0 -0.48 836270.0 -85900.0 -0.43 1172010.0 106098.4375 0.584103721228265 -0.1861 -0.2144 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 N24 mock treatment 905920.0 -65000.0 -0.37 1007600.0 85400.0 0.43 1084980.0 19068.4375 0.104977467757323 0.0928 0.1613 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O01 compound treatment 1195410.0 224000.0 1.28 1038900.0 117000.0 0.58 1029890.0 -36021.5625 -0.198309505742783 0.9629 0.6767 1664938 Maybridge1_006821 Cc1c(OCC(=O)Nc2ccc(Cl)cc2C(=O)c3ccccc3Cl)ccc4C(=O)CC(C)(C)Oc14 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O02 compound treatment 1153650.0 183000.0 1.04 1122830.0 201000.0 1.0 1166110.0 100198.4375 0.551622451603095 1.5005 0.9684 1466695 Maybridge1_006822 O=C(Cc1ccccc1)N2CCNCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O03 compound treatment 867870.0 -103000.0 -0.59 901690.0 -20500.0 -0.1 989070.0 -76841.5625 -0.423035849149468 -0.6433 -0.8787 1641395 Maybridge1_006823 COc1cc(ccc1O)C(=O)c2cc(Cl)ccc2N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O04 compound treatment 845620.0 -125000.0 -0.72 887530.0 -34700.0 -0.17 870880.0 -195031.5625 -1.0737072486408 -1.1333 -0.8704 2073019 Maybridge1_006824 CCc1ccc(NC(=O)/C=C/c2ccc(N3CCC(CC3)c4ccccc4OC)c(c2)[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O05 compound treatment 1019480.0 48600.0 0.28 687200.0 -235000.0 -1.18 836130.0 -229781.5625 -1.26501642143312 -1.2488 -0.7141 2073020 Maybridge1_006825 [O-][N+](=O)c1cc(Cl)ccc1NCNc2ccc(Cl)cc2[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O06 compound treatment 934110.0 -36800.0 -0.21 872380.0 -49800.0 -0.25 1144050.0 78138.4375 0.430175535004577 -0.0169 -0.0313 2073021 Maybridge1_006826 CCOC(=O)CSc1cc(c(Cl)cc1[N+](=O)[O-])n2cccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O07 compound treatment 911160.0 -59800.0 -0.34 941280.0 19100.0 0.1 1175680.0 109768.4375 0.604308171995108 0.2069 0.2953 2073022 Maybridge1_006827 OC(=O)C1=CN(C2CCCCC2)c3ccccc3C1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O08 compound treatment 1084540.0 114000.0 0.65 724260.0 -198000.0 -0.99 832500.0 -233411.5625 -1.2850006602025 -0.9388 -0.5373 2073023 Maybridge1_006828 Cc1ccc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)c3CCCc31 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O09 compound treatment 833820.0 -137000.0 -0.78 640670.0 -282000.0 -1.41 919170.0 -146741.5625 -0.807856314708687 -1.7316 -0.9607 2073024 Maybridge1_006829 COC(=O)C1Cc2c([nH]c3ccccc23)C4(CCN(Cc5ccccc5)CC4)N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O10 compound treatment 1006850.0 35900.0 0.21 776350.0 -146000.0 -0.73 906680.0 -159231.5625 -0.876617510915192 -0.8088 -0.698 2073025 Maybridge1_006830 Cc1ccc(OCc2nnc(SCc3c(F)cccc3Cl)n2c4ccccc4)c5CCCc51 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O11 compound treatment 967100.0 -3830.0 -0.02 822610.0 -99600.0 -0.5 1039080.0 -26831.5625 -0.147715799326628 -0.3855 -0.7413 1454277 Maybridge1_006831 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3cccc(Br)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O12 compound treatment 845520.0 -125000.0 -0.72 820810.0 -101000.0 -0.51 861550.0 -204361.5625 -1.12507169704806 -1.3559 -0.9502 1385820 Maybridge1_006832 Fc1ccc(cc1)C(=O)c2cc3cc(Br)cc(Br)c3o2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O13 compound treatment 902170.0 -68800.0 -0.39 802480.0 -120000.0 -0.6 782090.0 -283821.5625 -1.56252282999993 -1.4746 -0.8579 2073026 Maybridge1_006833 O/N=C/c1ccc2OCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O14 compound treatment 789280.0 -182000.0 -1.04 811110.0 -111000.0 -0.56 943290.0 -122621.5625 -0.675068480241043 -1.3096 -0.9652 1675089 Maybridge1_006834 Cc1cc(Br)c(OCC(=O)NN)c2CCCc21 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O15 compound treatment 910650.0 -60300.0 -0.34 834120.0 -88100.0 -0.44 899100.0 -166811.5625 -0.918347684433631 -0.9833 -0.9146 1565927 Maybridge1_006835 CC(C)(C)c1ccc(cc1)N2C(=O)c3cc(Cl)c(Cl)cc3C2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O16 compound treatment 860800.0 -110000.0 -0.63 774000.0 -148000.0 -0.74 1034240.0 -31671.5625 -0.17436145101914 -0.8918 -0.9029 2073027 Maybridge1_006836 CN(C)/C(=C\1/N=C(OC1=O)c2ccccc2)/C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O17 compound treatment 811530.0 -159000.0 -0.91 745670.0 -177000.0 -0.88 969700.0 -96211.5625 -0.529673508918883 -1.3413 -0.9758 1255675 Maybridge1_006837 O=C(NC1CCN(Cc2c[nH]c3ccccc23)CC1)C4CCCCC4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O18 compound treatment 960530.0 -10400.0 -0.06 810610.0 -112000.0 -0.56 945150.0 -120761.5625 -0.664828622359209 -0.7404 -0.8509 2073028 Maybridge1_006838 Cc1ccc(cc1)S(=O)(=O)Nc2cc(ccc2Oc3ccc(C)c4CCCc43)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O19 compound treatment 917140.0 -53800.0 -0.31 723600.0 -199000.0 -0.99 865880.0 -200031.5625 -1.10123374832315 -1.3867 -0.9156 2073029 Maybridge1_006839 O=C(CSCc1cccc2ccccc12)NNC(=S)Nc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O20 compound treatment 1086430.0 116000.0 0.66 856320.0 -65900.0 -0.33 1029940.0 -35971.5625 -0.198034240745959 0.0764 0.1 1028002 Maybridge1_006840 OCCCN1C(=O)c2ccccc2C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O21 compound treatment 1078370.0 107000.0 0.61 777370.0 -145000.0 -0.72 955630.0 -110281.5625 -0.607133079025009 -0.4144 -0.3677 1259711 Maybridge1_006841 COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)c3cncc(Br)c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O22 compound treatment 1057440.0 86500.0 0.49 764560.0 -158000.0 -0.79 1011600.0 -54311.5625 -0.29900144158081 -0.3425 -0.3504 1036029 Maybridge1_006842 OC(=O)CCC(=O)Nc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O23 mock treatment 1235430.0 265000.0 1.51 891280.0 -30900.0 -0.15 1208480.0 142568.4375 0.784882009911308 1.2362 0.7231 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 O24 mock treatment 1400870.0 430000.0 2.46 1111010.0 189000.0 0.94 1155680.0 89768.4375 0.494202173265718 2.2485 0.8398 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P01 compound treatment 673710.0 -297000.0 -1.7 914670.0 -7530.0 -0.04 1020570.0 -45341.5625 -0.249618901150679 -1.1461 -0.6677 2073030 Maybridge1_006843 Cc1cc(C)c(C(=O)NCCNc2ccc(cc2[N+](=O)[O-])C(F)(F)F)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P02 compound treatment 968770.0 -2160.0 -0.01 881650.0 -40500.0 -0.2 909390.0 -156521.5625 -0.861698148087359 -0.6217 -0.7022 2073031 Maybridge1_006844 O=C(CC(=O)c1ccccn1)c2ccccn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P03 compound treatment 1169760.0 199000.0 1.14 1043970.0 122000.0 0.61 943680.0 -122231.5625 -0.67292141326582 0.6189 0.4257 1673412 Maybridge1_006845 Brc1ccc2OC(=O)C(Cc2c1)C(=O)N3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P04 compound treatment 762530.0 -208000.0 -1.19 629460.0 -293000.0 -1.46 637760.0 -428151.5625 -2.35710276983057 -2.8935 -0.9583 1143576 Maybridge1_006846 Cc1ccc2cc(NC(=O)c3ccccc3)ccc2n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P05 compound treatment 1241310.0 270000.0 1.54 1041950.0 120000.0 0.6 1124960.0 59048.4375 0.325079359217374 1.4252 0.8442 2073032 Maybridge1_006847 COc1ccc(cc1)S(=O)(=O)NNC(=O)c2ccc(cc2)n3c(C)ccc3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P06 compound treatment 1245050.0 274000.0 1.57 1044680.0 122000.0 0.61 1134920.0 69008.4375 0.379912146584611 1.4771 0.8569 1150448 Maybridge1_006848 CCc1ccc(cc1)C(=O)Nc2ccc3nc(C)ccc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P07 compound treatment 1181630.0 211000.0 1.2 825040.0 -97200.0 -0.49 884970.0 -180941.5625 -0.996137572535945 -0.1608 -0.0983 2073033 Maybridge1_006849 COc1ccc(cc1OC)C(=O)NNC(=O)c2ccc(cc2)n3c(C)ccc3C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P08 compound treatment 1043610.0 72700.0 0.42 1123200.0 201000.0 1.01 1126950.0 61038.4375 0.336034906090948 1.0142 0.8908 2073034 Maybridge1_006850 CC(=O)OC[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@H](OC(=O)C)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P09 compound treatment 1178400.0 207000.0 1.19 858110.0 -64100.0 -0.32 984800.0 -81111.5625 -0.446543479878193 0.2414 0.1848 1405837 Maybridge1_006851 COc1ccc(Oc2ncccc2NS(=O)(=O)c3ccc(OC)cc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P10 compound treatment 1118050.0 147000.0 0.84 774110.0 -148000.0 -0.74 1015290.0 -50621.5625 -0.278686884815238 -0.1033 -0.0895 2073035 Maybridge1_006852 CC(=NNC(=N)NC(=S)Nc1ccccc1)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P11 compound treatment 1022080.0 51200.0 0.29 791560.0 -131000.0 -0.65 927710.0 -138201.5625 -0.760841053251238 -0.6478 -0.6201 1637974 Maybridge1_006853 Cc1ccc(C)n1c2ccc(cc2)C(=O)ON3C(=O)CCC3=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P12 compound treatment 1157280.0 186000.0 1.06 1023540.0 101000.0 0.51 1050880.0 -15031.5625 -0.0827532600762876 0.8595 0.7272 2073036 Maybridge1_006854 CCCCCCCc1c(O)c2ccccc2[nH]c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P13 compound treatment 1137190.0 166000.0 0.95 823840.0 -98400.0 -0.49 964660.0 -101251.5625 -0.557420220598689 -0.0575 -0.0477 2073037 Maybridge1_006855 Cc1cc(Oc2ccccc2)ccc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P14 compound treatment 848590.0 -122000.0 -0.7 799630.0 -123000.0 -0.61 1077760.0 11848.4375 0.065229202216013 -0.7198 -0.7723 1050525 Maybridge1_006856 CCCC(NC(=O)C(C)N)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P15 compound treatment 951330.0 -19600.0 -0.11 840100.0 -82100.0 -0.41 1090590.0 24678.4375 0.135862200400917 -0.2233 -0.4997 1044269 Maybridge1_006857 Cc1nc(O)c([N+](=O)[O-])c(O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P16 compound treatment 961130.0 -9800.0 -0.06 810560.0 -112000.0 -0.56 961770.0 -104141.5625 -0.573330537415086 -0.6857 -0.8547 1926183 Maybridge1_006858 O=C1C(C(=O)c2ccccc12)c3cccc4ccccc34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P17 compound treatment 824120.0 -147000.0 -0.84 894790.0 -27400.0 -0.14 1010020.0 -55891.5625 -0.307699815480432 -0.741 -0.8199 2073038 Maybridge1_006859 Cc1cc(c(C#N)c(=O)[nH]1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P18 compound treatment 1218240.0 247000.0 1.41 933550.0 11400.0 0.06 1092090.0 26178.4375 0.144120150305621 0.9316 0.6555 1464027 Maybridge1_006860 OC(=O)c1cn(C2CCCCC2)c3ccccc3c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P19 compound treatment 1242610.0 272000.0 1.55 809190.0 -113000.0 -0.57 1121840.0 55928.4375 0.307902823415589 0.7475 0.4449 2073039 Maybridge1_006861 O=C(CC#N)NNC(=S)NCC1CCCO1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P20 compound treatment 1086670.0 116000.0 0.66 809930.0 -112000.0 -0.56 960530.0 -105381.5625 -0.580157109336308 -0.2774 -0.2658 2073040 Maybridge1_006862 CC/1(C)C2CC[C@](C)(C2)\C1=N\OC(=O)c3cccc(c3)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P21 compound treatment 1006630.0 35700.0 0.2 725830.0 -196000.0 -0.98 987920.0 -77991.5625 -0.429366944076408 -0.6972 -0.639 1165383 Maybridge1_006863 Cc1cc(N2CCN(CC2)c3nc4cc(Cl)ccc4s3)c5ccccc5n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P22 compound treatment 1177000.0 206000.0 1.18 1044320.0 122000.0 0.61 1182080.0 116168.4375 0.639542091588513 1.4015 0.9519 2073041 Maybridge1_006864 NNC(=O)[C@H]1C[C@H]1C(=O)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P23 mock treatment 1270030.0 299000.0 1.71 1133320.0 211000.0 1.06 1109710.0 43798.4375 0.241123535186214 1.7353 0.8578 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.560 P24 mock treatment 1200320.0 229000.0 1.31 983050.0 60900.0 0.3 1088010.0 22098.4375 0.121658526564826 1.0025 0.7422 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A01 compound treatment 844160.0 -5090.0 -0.03 938450.0 -72700.0 -0.36 1232090.0 227305.0 1.2513822020592 0.4957 0.3803 2073042 Maybridge1_006865 Cc1cc(C)nc(SC(=O)OC(C)(C)C)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A02 compound treatment 859120.0 9870.0 0.06 947320.0 -63900.0 -0.32 1150670.0 145885.0 0.803140681231855 0.3119 0.36 2073043 Maybridge1_006866 Cc1nc(SCc2c(F)cccc2Cl)nc(O)c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A03 compound treatment 901700.0 52500.0 0.3 994320.0 -16900.0 -0.08 1208560.0 203775.0 1.12184249455408 0.772 0.6631 1208677 Maybridge1_006867 OC(=O)CNC(=O)c1ccccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A04 compound treatment 267840.0 -581000.0 -3.32 320700.0 -690000.0 -3.45 404000.0 -600785.0 -3.30750162233184 -5.821 -0.9998 2073044 Maybridge1_006868 Clc1cc(Cl)cc(NC(=S)NCc2cccs2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A05 compound treatment 855290.0 6040.0 0.03 1053670.0 42500.0 0.21 1084230.0 79445.0 0.437368553452821 0.3951 0.8106 2073045 Maybridge1_006869 CC(=O)c1c(C)n(O)c2ccc3nonc3c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A06 compound treatment 910110.0 60900.0 0.35 960320.0 -50900.0 -0.25 1125280.0 120495.0 0.663361115844894 0.4369 0.5523 2073046 Maybridge1_006870 COCc1cc(O)nc(S)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A07 compound treatment 830780.0 -18500.0 -0.11 942020.0 -69200.0 -0.35 1074530.0 69745.0 0.383967144069066 -0.0389 -0.0738 1520977 Maybridge1_006871 CC(C)(C)c1ccc(cc1)C(=O)N2CCC(CC2)NC(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A08 compound treatment 892820.0 43600.0 0.25 1008610.0 -2560.0 -0.01 1049760.0 44975.0 0.247600864642716 0.2792 0.7949 2073047 Maybridge1_006872 Cc1cc(Br)ccc1Nc2ncnc(N)n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A09 compound treatment 878360.0 29100.0 0.17 956520.0 -54700.0 -0.27 1082820.0 78035.0 0.429606080542399 0.1862 0.3476 1307029 Maybridge1_006873 COc1ccccc1CC(=O)NC2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A10 compound treatment 897190.0 47900.0 0.27 1054780.0 43600.0 0.22 1172440.0 167655.0 0.922991060848797 0.8169 0.8275 2073048 Maybridge1_006874 Clc1cccc(NC(=S)NNC(=O)C2CC2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A11 compound treatment 779960.0 -69300.0 -0.4 987620.0 -23600.0 -0.12 1046250.0 41465.0 0.228277261865708 -0.1647 -0.3491 2073049 Maybridge1_006875 COc1ccc(CCNS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A12 compound treatment 677720.0 -172000.0 -0.98 975310.0 -35900.0 -0.18 1025170.0 20385.0 0.112225539204931 -0.6045 -0.603 2073050 Maybridge1_006876 COCc1cc(O)nc(NC(=N)Nc2ccc(Cl)c(Cl)c2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A13 compound treatment 762720.0 -86500.0 -0.49 969760.0 -41400.0 -0.21 1074800.0 70015.0 0.385453575051913 -0.1824 -0.2763 1130829 Maybridge1_006877 Clc1cccc(c1Cl)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A14 compound treatment 826920.0 -22300.0 -0.13 1017950.0 6780.0 0.03 1089670.0 84885.0 0.467317385107215 0.2157 0.4442 1698799 Maybridge1_006878 OC(=O)CCNC(=S)Nc1ccc(F)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A15 compound treatment 589530.0 -260000.0 -1.48 904890.0 -106000.0 -0.53 884530.0 -120255.0 -0.662039843860142 -1.5457 -0.9042 1523035 Maybridge1_006879 CC1(C)C2CCC1(C)C(C2)(Nc3ccccc3)C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A16 compound treatment 809760.0 -39500.0 -0.23 985680.0 -25500.0 -0.13 1091400.0 86615.0 0.476841553997307 0.0714 0.1316 1525521 Maybridge1_006880 Cc1nc(N)nc(O)c1Cc2c(F)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A17 compound treatment 809800.0 -39500.0 -0.23 937790.0 -73400.0 -0.37 1024280.0 19495.0 0.107325822261473 -0.2801 -0.6309 2073051 Maybridge1_006881 C/C(=C\c1ccccc1[N+](=O)[O-])/c2cc3ccccc3c4ccccc24 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A18 compound treatment 829560.0 -19700.0 -0.11 1041970.0 30800.0 0.15 1085520.0 80735.0 0.444470390370866 0.2806 0.5802 2073052 Maybridge1_006882 CSc1nc(C)c(CC(=C)C)c(O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A19 compound treatment 782330.0 -66900.0 -0.38 956240.0 -54900.0 -0.27 992640.0 -12145.0 -0.0668618677284223 -0.4179 -0.879 2073053 Maybridge1_006883 N#CCc1nc(cs1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A20 compound treatment 690820.0 -158000.0 -0.91 767160.0 -244000.0 -1.22 899120.0 -105665.0 -0.581717517787051 -1.563 -0.9607 2073054 Maybridge1_006884 CSC(=N)NC(=S)Nc1cccc(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A21 compound treatment 824260.0 -25000.0 -0.14 961330.0 -49800.0 -0.25 1089140.0 84355.0 0.464399576140886 0.0418 0.0765 1067983 Maybridge1_006885 Oc1ccc2c(cc(=O)oc2c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A22 compound treatment 827680.0 -21600.0 -0.12 1049920.0 38700.0 0.19 1073710.0 68925.0 0.379452798121161 0.2598 0.5858 2073055 Maybridge1_006886 CC(C)(C)/N=C(\NN)/NCC1CC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A23 mock treatment 837890.0 -11400.0 -0.06 991450.0 -19700.0 -0.1 1133510.0 128725.0 0.708669734322038 0.3147 0.4381 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 A24 mock treatment 800270.0 -49000.0 -0.28 956420.0 -54800.0 -0.27 1108440.0 103655.0 0.570651864914748 0.0098 0.0142 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B01 compound treatment 884880.0 35600.0 0.2 1049340.0 38200.0 0.19 899680.0 -105105.0 -0.578634549822629 -0.1064 -0.1656 2073056 Maybridge1_006887 CC(C)(C)C(=O)Cn1nnc(n1)c2cc(Cl)cc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B02 compound treatment 632540.0 -217000.0 -1.24 699850.0 -311000.0 -1.56 612730.0 -392055.0 -2.15838036659256 -2.8599 -0.9743 1076487 Maybridge1_006888 COc1ccc(CCN2CSC(=S)N(CCc3ccc(OC)c(OC)c3)C2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B03 compound treatment 794270.0 -55000.0 -0.31 967200.0 -44000.0 -0.22 878470.0 -126315.0 -0.695401961475147 -0.7098 -0.8938 2073057 Maybridge1_006889 NNC(=O)Cn1nnc(n1)c2cccc(c2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B04 compound treatment 745440.0 -104000.0 -0.59 937720.0 -73500.0 -0.37 858100.0 -146685.0 -0.807544921181031 -1.0207 -0.9565 1080223 Maybridge1_006890 CCOC(=O)c1ccc(NC(=S)NC(=O)c2ccccc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B05 compound treatment 810100.0 -39200.0 -0.22 839200.0 -172000.0 -0.86 927300.0 -77485.0 -0.42657816557734 -0.872 -0.8846 1668302 Maybridge1_006891 CCCc1cc(=O)oc2cc(OCC(=O)NN)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B06 compound treatment 834980.0 -14300.0 -0.08 851690.0 -159000.0 -0.8 949560.0 -55225.0 -0.304030188991529 -0.6831 -0.7966 2073058 Maybridge1_006892 Cc1cc(C)c(NC(=O)CC2SC(=N)NC2=O)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B07 compound treatment 797850.0 -51400.0 -0.29 855750.0 -155000.0 -0.78 884320.0 -120465.0 -0.6631959568468 -1.0012 -0.9417 1364298 Maybridge1_006893 COCc1cc(=O)oc2cc(O)c(Cl)cc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B08 compound treatment 792350.0 -56900.0 -0.33 885810.0 -125000.0 -0.63 876820.0 -127965.0 -0.704485706370322 -0.9564 -0.9588 2073059 Maybridge1_006894 CCO/C=C/1\SC(=S)N(CCc2ccccc2)C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B09 compound treatment 936640.0 87400.0 0.5 908410.0 -103000.0 -0.51 1007780.0 2995.0 0.0164883733097262 0.001 0.0014 2073060 Maybridge1_006895 NNC(=S)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B10 compound treatment 58290.0 -791000.0 -4.52 115250.0 -896000.0 -4.48 74330.0 -930455.0 -5.12243385238774 -8.1532 -0.9981 2073061 Maybridge1_006896 [O-][N+](=O)/C=C/c1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B11 compound treatment 769020.0 -80200.0 -0.46 980350.0 -30800.0 -0.15 921780.0 -83005.0 -0.456967421226652 -0.6174 -0.9281 2073062 Maybridge1_006897 Sc1nc2ccccc2[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B12 compound treatment 633020.0 -216000.0 -1.24 756700.0 -254000.0 -1.27 780530.0 -224255.0 -1.23459103725297 -2.1608 -0.9999 1275541 Maybridge1_006898 CC(N1CSC(=S)N(C1)C(C)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B13 compound treatment 978640.0 129000.0 0.74 902830.0 -108000.0 -0.54 986740.0 -18045.0 -0.0993431373535924 0.0565 0.0613 2073063 Maybridge1_006899 Cc1cccc(Cl)c1NC(=S)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B14 compound treatment 793760.0 -55500.0 -0.32 883720.0 -127000.0 -0.64 817140.0 -187645.0 -1.03304200657882 -1.1475 -0.9146 2073064 Maybridge1_006900 Clc1ccc(/N=C\2/NCCS2)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B15 compound treatment 792670.0 -56600.0 -0.32 912960.0 -98200.0 -0.49 858590.0 -146195.0 -0.804847324212161 -0.9349 -0.9379 2073065 Maybridge1_006901 N/C(=N\O)/Cc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B16 compound treatment 876070.0 26800.0 0.15 957140.0 -54000.0 -0.27 924110.0 -80675.0 -0.444140072374678 -0.324 -0.5978 1683503 Maybridge1_006902 CCc1ccccc1Nc2nnc(S)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B17 compound treatment 30400.0 -819000.0 -4.68 34800.0 -976000.0 -4.88 37850.0 -966935.0 -5.32326719407015 -8.5935 -0.9985 2073066 Maybridge1_006903 Cc1ccc(/C=C/[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B18 compound treatment 816640.0 -32600.0 -0.19 832110.0 -179000.0 -0.9 999290.0 -5495.0 -0.0302516231509 -0.6421 -0.7015 1671035 Maybridge1_006904 Cc1cccc(NCN2C(=O)c3ccccc3C2=O)c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B19 compound treatment 921870.0 72600.0 0.41 805220.0 -206000.0 -1.03 923590.0 -81195.0 -0.447002828341642 -0.6133 -0.5123 2073067 Maybridge1_006905 CCN(CC)c1ccc(/C=C/2\N=C(OC2=O)c3ccccc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B20 compound treatment 629920.0 -219000.0 -1.25 736530.0 -275000.0 -1.37 750210.0 -254575.0 -1.40151173132673 -2.3256 -0.9988 2073068 Maybridge1_006906 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc(Cl)cn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B21 compound treatment 731840.0 -117000.0 -0.67 787900.0 -223000.0 -1.12 812200.0 -192585.0 -1.06023818826498 -1.6441 -0.9789 1074249 Maybridge1_006907 CC1CCN(CC1)c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B22 compound treatment 30990.0 -818000.0 -4.67 36130.0 -975000.0 -4.88 35840.0 -968945.0 -5.33433284694245 -8.5941 -0.9985 2073069 Maybridge1_006908 [O-][N+](=O)/C=C/c1ccccc1[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B23 mock treatment 928640.0 79400.0 0.45 1136040.0 125000.0 0.62 1095480.0 90695.0 0.499303177738103 0.9107 0.9907 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 B24 mock treatment 901800.0 52600.0 0.3 1089450.0 78300.0 0.39 1146340.0 141555.0 0.779302732506942 0.8493 0.9208 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C01 compound treatment 566910.0 -282000.0 -1.61 796960.0 -214000.0 -1.07 1256690.0 251905.0 1.38681258049635 -0.7491 -0.3145 1464302 Maybridge1_006909 CC(NCc1ccccc1)C2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C02 compound treatment 512030.0 -337000.0 -1.93 817280.0 -194000.0 -0.97 877200.0 -127585.0 -0.702393692394463 -2.0776 -0.916 2073070 Maybridge1_006910 C1CCN(CC1)c2nn[nH]n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C03 compound treatment 530760.0 -318000.0 -1.82 785790.0 -225000.0 -1.13 852700.0 -152085.0 -0.837273540837966 -2.1846 -0.9506 2073071 Maybridge1_006911 CC(C)(C)c1cc([N+](=O)[O-])c2cc(cc([N+](=O)[O-])c2c1)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C04 compound treatment 419290.0 -430000.0 -2.46 653340.0 -358000.0 -1.79 785010.0 -219775.0 -1.20992729353759 -3.1499 -0.963 1313220 Maybridge1_006912 Cc1cc(Nc2ccc(F)c(Cl)c2)nc(N)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C05 compound treatment 516820.0 -332000.0 -1.9 758930.0 -252000.0 -1.26 834880.0 -169905.0 -0.935377985705853 -2.3648 -0.9596 1497623 Maybridge1_006913 CCOC(=O)c1c(C)n(OC)c2ccc3nonc3c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C06 compound treatment 650200.0 -199000.0 -1.14 837880.0 -173000.0 -0.87 917730.0 -87055.0 -0.479263885969354 -1.4336 -0.9507 2073072 Maybridge1_006914 COCc1cc(O)nc(SC)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C07 compound treatment 573170.0 -276000.0 -1.58 886840.0 -124000.0 -0.62 863620.0 -141165.0 -0.777155665531719 -1.7183 -0.9214 1260724 Maybridge1_006915 Clc1ccc(cc1)C(=O)N2CCC(CC2)NC(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C08 compound treatment 616510.0 -233000.0 -1.33 804240.0 -207000.0 -1.04 895920.0 -108865.0 -0.599334477583754 -1.7112 -0.9569 1030238 Maybridge1_006916 NC(=N)NC(=N)Nc1ccccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C09 compound treatment 632440.0 -217000.0 -1.24 799570.0 -212000.0 -1.06 878650.0 -126135.0 -0.694411007486582 -1.727 -0.9752 1394196 Maybridge1_006917 O=C(NC1CCN(Cc2ccccc2)CC1)c3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C10 compound treatment 602040.0 -247000.0 -1.41 741370.0 -270000.0 -1.35 789830.0 -214955.0 -1.1833917478438 -2.2777 -0.9973 1117027 Maybridge1_006918 NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C11 compound treatment 605380.0 -244000.0 -1.39 795680.0 -215000.0 -1.08 889930.0 -114855.0 -0.632311224203206 -1.7916 -0.9574 1778921 Maybridge1_006919 [O-][N+](=O)c1ccc(cc1)C(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C12 compound treatment 649610.0 -200000.0 -1.14 769380.0 -242000.0 -1.21 906130.0 -98655.0 -0.5431253652324 -1.6702 -0.9551 2073073 Maybridge1_006920 NC(=N)NC(=N)Nc1ccccc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C13 compound treatment 677620.0 -172000.0 -0.98 890090.0 -121000.0 -0.61 957920.0 -46865.0 -0.258005881522644 -1.0647 -0.9016 1216085 Maybridge1_006921 O=C(Cc1ccccc1)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C14 compound treatment 630560.0 -219000.0 -1.25 770140.0 -241000.0 -1.21 894470.0 -110315.0 -0.607317162491635 -1.7679 -0.9612 1324187 Maybridge1_006922 CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccc(F)cc2F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C15 compound treatment 632550.0 -217000.0 -1.24 778520.0 -233000.0 -1.16 897130.0 -107655.0 -0.592673064660626 -1.7287 -0.9607 2073074 Maybridge1_006923 COC(=O)C1C(=O)CC(=O)CC1(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C16 compound treatment 668520.0 -181000.0 -1.03 816070.0 -195000.0 -0.98 887760.0 -117025.0 -0.644257725065345 -1.5314 -0.9818 2073075 Maybridge1_006924 NC(=N)NC(=N)Nc1ccc2OCCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C17 compound treatment 652660.0 -197000.0 -1.12 759760.0 -251000.0 -1.26 844080.0 -160705.0 -0.884729226290334 -1.8852 -0.9901 2073076 Maybridge1_006925 CC(=O)[C@@H]1[C@H]([C@H](C(=O)C)[C@](C)(O)CC1=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C18 compound treatment 687910.0 -161000.0 -0.92 844860.0 -166000.0 -0.83 899770.0 -105015.0 -0.578139072828346 -1.3462 -0.9829 1617897 Maybridge1_006926 CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2cc(C)on2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C19 compound treatment 651300.0 -198000.0 -1.13 809690.0 -201000.0 -1.01 899970.0 -104815.0 -0.577038012841052 -1.5678 -0.9673 1006315 Maybridge1_006927 OC(=O)C(c1ccccc1)(c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C20 compound treatment 691850.0 -157000.0 -0.9 776900.0 -234000.0 -1.17 866950.0 -137835.0 -0.758823016743276 -1.6337 -0.9839 2073077 Maybridge1_006928 FC(F)(F)c1ccccc1c2nnn[nH]2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C21 compound treatment 671920.0 -177000.0 -1.01 796960.0 -214000.0 -1.07 858240.0 -146545.0 -0.806774179189925 -1.6692 -0.9931 2073078 Maybridge1_006929 NC(=N)NC(=N)Nc1ccc(F)cc1F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C22 compound treatment 740740.0 -109000.0 -0.62 790560.0 -221000.0 -1.1 841950.0 -162835.0 -0.896455515155014 -1.5125 -0.9752 2073079 Maybridge1_006930 S=C(NCC1CC1)NCC2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C23 mock treatment 686430.0 -163000.0 -0.93 858760.0 -152000.0 -0.76 948010.0 -56775.0 -0.312563403893057 -1.1576 -0.9316 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 C24 mock treatment 721220.0 -128000.0 -0.73 906090.0 -105000.0 -0.53 942560.0 -62225.0 -0.342567288546816 -0.9235 -0.9584 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D01 compound treatment 988800.0 140000.0 0.8 907680.0 -103000.0 -0.52 1247950.0 243165.0 1.33869625905161 0.9343 0.5691 1361400 Maybridge1_006931 Nc1ncnc(Nc2cccc(C#N)c2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D02 compound treatment 705510.0 -144000.0 -0.82 867330.0 -144000.0 -0.72 832190.0 -172595.0 -0.950187242534956 -1.438 -0.9936 1076055 Maybridge1_006932 CCOc1ccc(C=C(C#N)C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D03 compound treatment 749840.0 -99400.0 -0.57 828360.0 -183000.0 -0.91 804730.0 -200055.0 -1.10136277879041 -1.4916 -0.9686 2073080 Maybridge1_006933 CCCc1cc(O)nc(SCc2c(Cl)cccc2Cl)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D04 compound treatment 705860.0 -143000.0 -0.82 772230.0 -239000.0 -1.2 820000.0 -184785.0 -1.01729684876052 -1.7502 -0.9886 2073081 Maybridge1_006934 COc1ccc(CCN2C(=O)/C(=C/c3c(F)c(F)c(F)c(F)c3F)/SC2=S)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D05 compound treatment 584400.0 -265000.0 -1.51 644020.0 -367000.0 -1.84 622050.0 -382735.0 -2.10707097118466 -3.1502 -0.9912 2073082 Maybridge1_006935 CCCc1cc(O)nc(NC(=N)Nc2cc(Cl)cc(Cl)c2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D06 compound treatment 772320.0 -76900.0 -0.44 799150.0 -212000.0 -1.06 848580.0 -156205.0 -0.859955376576221 -1.3625 -0.9499 1351539 Maybridge1_006936 O=C1Nc2ccccc2C1(C3C(=O)NC(=O)NC3=O)C4C(=O)NC(=O)NC4=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D07 compound treatment 830080.0 -19200.0 -0.11 767780.0 -243000.0 -1.22 839150.0 -165635.0 -0.911870354977128 -1.2925 -0.8476 2073083 Maybridge1_006937 Clc1cccc(c2nnn[nH]2)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D08 compound treatment 712080.0 -137000.0 -0.78 790400.0 -221000.0 -1.1 769280.0 -235505.0 -1.29652566153825 -1.8385 -0.9807 2073084 Maybridge1_006938 Clc1cccc(Cl)c1NC(=S)NC(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D09 compound treatment 601040.0 -248000.0 -1.42 746240.0 -265000.0 -1.33 573140.0 -431645.0 -2.37633519107738 -2.9556 -0.9633 1603314 Maybridge1_006939 Fc1ccc(NC(=S)NC2CCCCCCCCCCC2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D10 compound treatment 796340.0 -52900.0 -0.3 856430.0 -155000.0 -0.77 833850.0 -170935.0 -0.941048444640417 -1.1647 -0.9277 1023877 Maybridge1_006940 CC(C)C(NS(=O)(=O)c1ccc(C)cc1)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D11 compound treatment 796820.0 -52400.0 -0.3 786210.0 -225000.0 -1.13 887360.0 -117425.0 -0.646459845039933 -1.1958 -0.8979 2073085 Maybridge1_006941 Fc1ccccc1Nc2nnc(S)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D12 compound treatment 741200.0 -108000.0 -0.62 888480.0 -123000.0 -0.61 788370.0 -216415.0 -1.19142948575105 -1.3985 -0.9478 2073086 Maybridge1_006942 NNC(=S)NCCCN1CCOCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D13 compound treatment 935240.0 86000.0 0.49 848750.0 -162000.0 -0.81 1015750.0 10965.0 0.0603656138033882 -0.1506 -0.1583 1065962 Maybridge1_006943 NNC(=S)Nc1cccc(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D14 compound treatment 745980.0 -103000.0 -0.59 955520.0 -55700.0 -0.28 789120.0 -215665.0 -1.1873005107987 -1.1868 -0.8761 2073087 Maybridge1_006944 Clc1cccc(NC2=NCCS2)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D15 compound treatment 639280.0 -210000.0 -1.2 666240.0 -345000.0 -1.73 758800.0 -245985.0 -1.35422120487245 -2.4704 -0.9882 1014454 Maybridge1_006945 O=c1oc(nc2ccccc12)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D16 compound treatment 27210.0 -822000.0 -4.7 30090.0 -981000.0 -4.91 33060.0 -971725.0 -5.34963758076584 -8.6328 -0.9985 2073088 Maybridge1_006946 CCOc1ccc(/C=C(\C)/[N+](=O)[O-])cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D17 compound treatment 646980.0 -202000.0 -1.16 731390.0 -280000.0 -1.4 741510.0 -263275.0 -1.44940784077401 -2.3118 -0.9954 1037879 Maybridge1_006947 NC(=N)SCc1ccccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D18 compound treatment 749390.0 -99900.0 -0.57 1032680.0 21500.0 0.11 820690.0 -184095.0 -1.01349819180436 -0.8524 -0.7298 2073089 Maybridge1_006948 CSc1cccc(NC(=S)NCc2cccnc2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D19 compound treatment 853960.0 4710.0 0.03 871950.0 -139000.0 -0.7 971730.0 -33055.0 -0.1819776894 -0.4916 -0.6825 2073090 Maybridge1_006949 CCN(CC)c1ccc(/C=N/N=C/c2ccc(cc2)N(CC)CC)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D20 compound treatment 733890.0 -115000.0 -0.66 845380.0 -166000.0 -0.83 831410.0 -173375.0 -0.954481376485402 -1.4103 -0.9891 2073091 Maybridge1_006950 Oc1ccccc1/C=N/c2ccc(Cl)cn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D21 compound treatment 711690.0 -138000.0 -0.79 818200.0 -193000.0 -0.97 770400.0 -234385.0 -1.29035972560941 -1.7559 -0.9794 1039360 Maybridge1_006951 CN(C)C(=S)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D22 compound treatment 704130.0 -145000.0 -0.83 822250.0 -189000.0 -0.94 883330.0 -121455.0 -0.668646203783905 -1.4102 -0.9905 2073092 Maybridge1_006952 CC(=O)Nc1ccc(cc1)C2=N/C(=C\c3cccs3)/C(=O)O2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D23 mock treatment 785490.0 -63800.0 -0.36 826360.0 -185000.0 -0.92 932390.0 -72395.0 -0.398556188900711 -0.9741 -0.9099 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 D24 mock treatment 791080.0 -58200.0 -0.33 1111610.0 100000.0 0.5 919010.0 -85775.0 -0.472217102050673 -0.1745 -0.2279 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E01 compound treatment 822830.0 -26400.0 -0.15 930530.0 -80600.0 -0.4 1084800.0 80015.0 0.440506574416608 -0.0657 -0.1066 1005170 Maybridge1_006953 OC(=O)C(c1ccc(Cl)cc1)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E02 compound treatment 732220.0 -117000.0 -0.67 882330.0 -129000.0 -0.64 916820.0 -87965.0 -0.484273708911541 -1.0376 -0.9908 1402665 Maybridge1_006954 Clc1ccc(cc1)C(=O)Cn2nnc(n2)N3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E03 compound treatment 726240.0 -123000.0 -0.7 791200.0 -220000.0 -1.1 849210.0 -155575.0 -0.856487037616245 -1.5354 -0.9834 1077391 Maybridge1_006955 COc1cc(CC#N)c(OC)cc1CC#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E04 compound treatment 732410.0 -117000.0 -0.67 806450.0 -205000.0 -1.02 858240.0 -146545.0 -0.806774179189925 -1.4423 -0.9848 1322296 Maybridge1_006956 Cc1cc(Nc2ccc(F)cc2F)nc(N)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E05 compound treatment 735620.0 -114000.0 -0.65 814790.0 -196000.0 -0.98 871330.0 -133455.0 -0.734709803021539 -1.366 -0.9843 2073093 Maybridge1_006957 CCCCCCCCCCCCC/1CCCC\C1=N\O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E06 compound treatment 705540.0 -144000.0 -0.82 785920.0 -225000.0 -1.13 851690.0 -153095.0 -0.842833893773801 -1.611 -0.989 1256576 Maybridge1_006958 Cc1cc(C)c(N=c2oc(cs2)C(C)(C)C)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E07 compound treatment 758100.0 -91200.0 -0.52 908910.0 -102000.0 -0.51 879230.0 -125555.0 -0.69121793352343 -0.995 -0.9898 1456979 Maybridge1_006959 Brc1ccccc1C(=O)N2CCC(CC2)NC(=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E08 compound treatment 792920.0 -56300.0 -0.32 853610.0 -158000.0 -0.79 903610.0 -101175.0 -0.556998721072303 -0.9624 -0.946 2073094 Maybridge1_006960 NC(=N)NC(=N)Nc1ccc(F)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E09 compound treatment 662900.0 -186000.0 -1.06 718180.0 -293000.0 -1.47 697970.0 -306815.0 -1.68910860000789 -2.4359 -0.9835 1736885 Maybridge1_006961 Clc1ccc(cc1)S(=O)(=O)NC2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E10 compound treatment 791360.0 -57900.0 -0.33 814240.0 -197000.0 -0.98 830920.0 -173865.0 -0.957178973454272 -1.3122 -0.9289 2073095 Maybridge1_006962 NC(=N)NC(=N)Nc1ccc(I)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E11 compound treatment 773960.0 -75300.0 -0.43 814460.0 -197000.0 -0.98 817760.0 -187025.0 -1.02962872061821 -1.4108 -0.9483 1670579 Maybridge1_006963 Clc1ccc(cc1)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E12 compound treatment 738240.0 -111000.0 -0.63 1030520.0 19300.0 0.1 836690.0 -168095.0 -0.925413392820843 -0.8445 -0.75 2073096 Maybridge1_006964 COCc1cc(O)nc(N)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E13 compound treatment 797280.0 -52000.0 -0.3 851410.0 -160000.0 -0.8 872010.0 -132775.0 -0.73096619906474 -1.0548 -0.9393 2073097 Maybridge1_006965 CC(C)(C)NS(=O)(=O)NC(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E14 compound treatment 924480.0 75200.0 0.43 851000.0 -160000.0 -0.8 942410.0 -62375.0 -0.343393083537286 -0.4127 -0.4246 2073098 Maybridge1_006966 OC(=O)CCNC(=S)Nc1cccc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E15 compound treatment 750240.0 -99000.0 -0.57 772600.0 -239000.0 -1.19 839740.0 -165045.0 -0.908622228014611 -1.5401 -0.9608 2073099 Maybridge1_006967 S(c1c(nc2sccn12)c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E16 compound treatment 791560.0 -57700.0 -0.33 813690.0 -197000.0 -0.99 867710.0 -137075.0 -0.754638988791559 -1.1962 -0.9302 2073100 Maybridge1_006968 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nn[nH]n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E17 compound treatment 700320.0 -149000.0 -0.85 707200.0 -304000.0 -1.52 716320.0 -288465.0 -1.58808634617368 -2.2858 -0.9697 2073101 Maybridge1_006969 O=C1c2ccccc2-c3ccc4ccccc4c13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E18 compound treatment 799270.0 -50000.0 -0.29 774840.0 -236000.0 -1.18 762470.0 -242315.0 -1.33401675410561 -1.6175 -0.8961 2073102 Maybridge1_006970 Cc1cc(NC(=N)NC(=N)N)no1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E19 compound treatment 968050.0 119000.0 0.68 845790.0 -165000.0 -0.83 995310.0 -9475.0 -0.0521627168980487 -0.1159 -0.1082 2073103 Maybridge1_006971 CC(=O)OC[C@H](OC(=O)C)[C@H](OC(=O)C)[C@@H](CNC(=O)c1ccc(C)c(C)c1)OC(=O)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E20 compound treatment 796970.0 -52300.0 -0.3 745070.0 -266000.0 -1.33 864990.0 -139795.0 -0.769613404618756 -1.3852 -0.8844 2073104 Maybridge1_006972 CCOC(=N)c1ccc(C)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E21 compound treatment 754670.0 -94600.0 -0.54 724190.0 -287000.0 -1.44 775840.0 -228945.0 -1.26041089395501 -1.8683 -0.9412 2073105 Maybridge1_006973 NC(=N)NC(=N)Nc1ccc(F)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E22 compound treatment 756990.0 -92300.0 -0.53 729790.0 -281000.0 -1.41 800090.0 -204695.0 -1.12690737049563 -1.7674 -0.9409 2073106 Maybridge1_006974 Fc1ccc(NC(=S)NCCNC(=S)Nc2ccc(F)cc2F)c(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E23 mock treatment 899970.0 50700.0 0.29 904350.0 -107000.0 -0.53 1003490.0 -1295.0 -0.00712936341772802 -0.1453 -0.2391 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 E24 mock treatment 1196320.0 347000.0 1.98 977550.0 -33600.0 -0.17 1100370.0 95585.0 0.526224094427439 1.3514 0.6566 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F01 compound treatment 812000.0 -37300.0 -0.21 861390.0 -150000.0 -0.75 826620.0 -178165.0 -0.980851763181091 -1.1217 -0.8956 1107832 Maybridge1_006975 CC1(C)CC2(C)OC(=O)c3ccccc3N2C(=S)N1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F02 compound treatment 68390.0 -781000.0 -4.46 75440.0 -936000.0 -4.68 86790.0 -917995.0 -5.05383781517933 -8.1953 -0.9987 1921381 Maybridge1_006976 CCOc1ccc(/C=C/[N+](=O)[O-])cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F03 compound treatment 745530.0 -104000.0 -0.59 797780.0 -213000.0 -1.07 757180.0 -247605.0 -1.36313979076953 -1.7453 -0.9538 1536659 Maybridge1_006977 CCCc1cc(=O)oc2cc(O)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F04 compound treatment 652960.0 -196000.0 -1.12 645770.0 -365000.0 -1.83 666290.0 -338495.0 -1.86351650199525 -2.7784 -0.9781 2073107 Maybridge1_006978 Nc1ccccc1SC(CC(=O)c2ccccc2)c3ccc(cc3)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F05 compound treatment 862630.0 13400.0 0.08 813120.0 -198000.0 -0.99 814120.0 -190665.0 -1.04966801238696 -1.1338 -0.7845 1061990 Maybridge1_006979 Nc1nc(N)nc(n1)c2ccccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F06 compound treatment 676610.0 -173000.0 -0.99 700220.0 -311000.0 -1.56 729410.0 -275375.0 -1.51602197000529 -2.3426 -0.9821 1497584 Maybridge1_006980 CC(C)c1ccc(cc1)N2CSC(=S)N(C2)c3ccc(cc3)C(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F07 compound treatment 1151320.0 302000.0 1.73 912030.0 -99100.0 -0.5 944970.0 -59815.0 -0.329299515699924 0.5198 0.2848 2073108 Maybridge1_006981 Nc1ccc(cc1)S(=O)(=O)Nc2ccccc2C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F08 compound treatment 839570.0 -9680.0 -0.06 813480.0 -198000.0 -0.99 828660.0 -176125.0 -0.969620951310693 -1.1626 -0.8388 2073109 Maybridge1_006982 Cc1cc(C)c(NC(=S)N)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F09 compound treatment 772880.0 -76400.0 -0.44 823890.0 -187000.0 -0.94 820870.0 -183915.0 -1.01250723781579 -1.3773 -0.952 2073110 Maybridge1_006983 COc1cc(/C=N/C2CCCCCCCCCCC2)ccc1OCc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F10 compound treatment 797600.0 -51700.0 -0.3 849940.0 -161000.0 -0.81 814420.0 -190365.0 -1.04801642240602 -1.241 -0.916 1211869 Maybridge1_006984 Cc1cc(NC(=O)CCC(=O)O)no1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F11 compound treatment 1009190.0 160000.0 0.91 806600.0 -205000.0 -1.02 932640.0 -72145.0 -0.397179863916593 -0.2926 -0.2049 2073111 Maybridge1_006985 COc1ccccc1Nc2nnc(S)s2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F12 compound treatment 33380.0 -816000.0 -4.66 39770.0 -971000.0 -4.86 42430.0 -962355.0 -5.29805292036112 -8.5547 -0.9985 2073112 Maybridge1_006986 C/C(=C\c1ccccc1Cl)/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F13 compound treatment 802560.0 -46700.0 -0.27 786960.0 -224000.0 -1.12 797080.0 -207705.0 -1.1434783233044 -1.4616 -0.9002 1119197 Maybridge1_006987 Cc1ccc(Cl)cc1NC(=S)NCCO 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F14 compound treatment 899000.0 49800.0 0.28 687950.0 -323000.0 -1.62 965920.0 -38865.0 -0.213963482030888 -0.8928 -0.5394 2073113 Maybridge1_006988 COc1ccc(CC/N=C/c2cc(Br)ccc2O)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F15 compound treatment 706880.0 -142000.0 -0.81 724580.0 -287000.0 -1.43 736900.0 -267885.0 -1.47478727348114 -2.1486 -0.9715 2073114 Maybridge1_006989 O=C/1OC(=N\C1=C/c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F16 compound treatment 27370.0 -822000.0 -4.69 30560.0 -981000.0 -4.9 29090.0 -975695.0 -5.37149362151362 -8.6436 -0.9984 2073115 Maybridge1_006990 C/C(=C\c1cccc(c1)[N+](=O)[O-])/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F17 compound treatment 786650.0 -62600.0 -0.36 819480.0 -192000.0 -0.96 814880.0 -189905.0 -1.04548398443524 -1.3636 -0.9321 1018868 Maybridge1_006991 NC(=N)SCc1ccc(Cl)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F18 compound treatment 732510.0 -117000.0 -0.67 774770.0 -236000.0 -1.18 796320.0 -208465.0 -1.14766235125612 -1.7303 -0.9734 2073116 Maybridge1_006992 Cc1cc(C)cc(/N=C/c2cc(Br)ccc2O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F19 compound treatment 664480.0 -185000.0 -1.06 689770.0 -321000.0 -1.61 800960.0 -203825.0 -1.1221177595509 -2.1854 -0.9815 2073117 Maybridge1_006993 NC(=N)SCc1cccc(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F20 compound treatment 764400.0 -84900.0 -0.48 786950.0 -224000.0 -1.12 838880.0 -165905.0 -0.913356785959975 -1.4547 -0.9536 2073118 Maybridge1_006994 Oc1ccccc1/C=N/c2ccccc2SCCC#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F21 compound treatment 788900.0 -60400.0 -0.34 753060.0 -258000.0 -1.29 798160.0 -206625.0 -1.13753259937301 -1.6011 -0.9124 1071877 Maybridge1_006995 COc1ccc(NC(=S)Nc2ccccn2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F22 compound treatment 859240.0 9990.0 0.06 819140.0 -192000.0 -0.96 825020.0 -179765.0 -0.989660243079443 -1.093 -0.7918 1111249 Maybridge1_006996 O=C1N(Nc2ccccc2)C(=O)c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F23 mock treatment 943650.0 94400.0 0.54 1056870.0 45700.0 0.23 925680.0 -79105.0 -0.435496751474421 0.1919 0.2629 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 F24 mock treatment 864870.0 15600.0 0.09 928530.0 -82600.0 -0.41 991040.0 -13745.0 -0.0756703476267735 -0.2308 -0.5373 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G01 compound treatment 919300.0 70100.0 0.4 905960.0 -105000.0 -0.53 1053880.0 49095.0 0.270282700380971 0.0833 0.1166 1219183 Maybridge1_006997 O=c1c(C#N)c2[nH]c3ccccc3n2c4ccccc14 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G02 compound treatment 807040.0 -42200.0 -0.24 832480.0 -179000.0 -0.89 877600.0 -127185.0 -0.700191572419875 -1.0595 -0.9128 1370310 Maybridge1_006998 CCOC(=O)Cn1nnc(n1)N2CCCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G03 compound treatment 727260.0 -122000.0 -0.7 756260.0 -255000.0 -1.27 868170.0 -136615.0 -0.752106550820783 -1.5727 -0.9612 1983575 Maybridge1_006999 Nc1oc(c(c1C#N)c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G04 compound treatment 771570.0 -77700.0 -0.44 799330.0 -212000.0 -1.06 877480.0 -127305.0 -0.700852208412252 -1.2726 -0.9457 1449956 Maybridge1_007000 Cc1cc(O)nc(NC(=O)C2CC2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G05 compound treatment 632850.0 -216000.0 -1.24 613670.0 -398000.0 -1.99 718440.0 -286345.0 -1.57641511030836 -2.7717 -0.982 2073119 Maybridge1_007001 CCCCCCCCCCCCCCCCC/1CCCC\C1=N\O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G06 compound treatment 835420.0 -13800.0 -0.08 814750.0 -196000.0 -0.98 873850.0 -130935.0 -0.720836447181636 -1.029 -0.8427 2073120 Maybridge1_007002 NC(=N)NC(=N)Nc1c(F)cccc1F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G07 compound treatment 729860.0 -119000.0 -0.68 883910.0 -127000.0 -0.64 884000.0 -120785.0 -0.66495765282647 -1.1452 -0.9996 1337485 Maybridge1_007003 COc1ccccc1C2CCN(CC2)C(=O)c3ccc(cc3)C(C)(C)C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G08 compound treatment 748660.0 -101000.0 -0.57 853700.0 -157000.0 -0.79 840540.0 -164245.0 -0.904217988065436 -1.3085 -0.9841 1013598 Maybridge1_007004 NC(=N)NC(=N)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G09 compound treatment 688160.0 -161000.0 -0.92 766480.0 -245000.0 -1.22 833600.0 -171185.0 -0.942424769624534 -1.782 -0.9911 1439324 Maybridge1_007005 CCOC(=O)c1ccc(NC(=O)CCCN2CCN(Cc3ccccc3)CC2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G10 compound treatment 743890.0 -105000.0 -0.6 779870.0 -231000.0 -1.16 819920.0 -184865.0 -1.01773727275544 -1.603 -0.969 2073121 Maybridge1_007006 Cc1ccc(NC(=N)NC(=N)N)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G11 compound treatment 744080.0 -105000.0 -0.6 773760.0 -237000.0 -1.19 841350.0 -163435.0 -0.899758695116895 -1.5519 -0.9661 1390951 Maybridge1_007007 Cc1ccc(cc1)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G12 compound treatment 728160.0 -121000.0 -0.69 889830.0 -121000.0 -0.61 818940.0 -185845.0 -1.02313246669318 -1.3405 -0.9741 2073122 Maybridge1_007008 NC(=N)NC(=N)Nc1cccc(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G13 compound treatment 577930.0 -271000.0 -1.55 501190.0 -510000.0 -2.55 615870.0 -388915.0 -2.14109372479204 -3.6037 -0.9811 2073123 Maybridge1_007009 CC1(O)CCCCCCCCCCC1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G14 compound treatment 806750.0 -42500.0 -0.24 782250.0 -229000.0 -1.14 795720.0 -209065.0 -1.150965531218 -1.4657 -0.8929 1600021 Maybridge1_007010 CC(C)(C)c1ccc(NC(=S)NCCC(=O)O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G15 compound treatment 827370.0 -21900.0 -0.12 830180.0 -181000.0 -0.91 825600.0 -179185.0 -0.98646716911629 -1.1644 -0.8659 2073124 Maybridge1_007011 NC(=O)c1c(cccc1C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G16 compound treatment 552070.0 -297000.0 -1.7 638430.0 -373000.0 -1.86 661480.0 -343305.0 -1.88999699468967 -3.1477 -0.9989 1700634 Maybridge1_007012 Clc1cc(Cl)cc(Nc2ncnc(n2)n3cccc3)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G17 compound treatment 554660.0 -295000.0 -1.68 685990.0 -325000.0 -1.63 620840.0 -383945.0 -2.11373238410779 -3.131 -0.9928 2073125 Maybridge1_007013 Cc1ccc(Oc2ccc(C)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G18 compound treatment 838720.0 -10500.0 -0.06 809720.0 -201000.0 -1.01 842950.0 -161835.0 -0.890950215218544 -1.1309 -0.8399 2073126 Maybridge1_007014 COc1ccccc1N/2C(=O)CS\C2=N/N=C/c3ccccc3O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G19 compound treatment 625520.0 -224000.0 -1.28 678810.0 -332000.0 -1.66 728960.0 -275825.0 -1.5184993549767 -2.5743 -0.9944 2073127 Maybridge1_007015 CCOc1c(C)nc(C)c(OCC)c1c2cccc(c2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G20 compound treatment 770050.0 -79200.0 -0.45 769190.0 -242000.0 -1.21 815400.0 -189385.0 -1.04262122846828 -1.5619 -0.9408 2073128 Maybridge1_007016 Cc1ccc(cc1Cl)c2nn[nH]n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G21 compound treatment 678770.0 -170000.0 -0.97 728660.0 -283000.0 -1.41 751470.0 -253315.0 -1.39457505340678 -2.1832 -0.9873 1103787 Maybridge1_007017 Nc1ccc2c(cc(=O)oc2c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G22 compound treatment 582240.0 -267000.0 -1.53 595560.0 -416000.0 -2.08 625700.0 -379085.0 -2.08697662641655 -3.2857 -0.9905 2073129 Maybridge1_007018 Clc1cccc(NC(=S)NCCNC(=S)Nc2cccc(Cl)c2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G23 mock treatment 864130.0 14900.0 0.09 866400.0 -145000.0 -0.72 897280.0 -107505.0 -0.591847269670155 -0.7107 -0.7568 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 G24 mock treatment 978840.0 130000.0 0.74 899810.0 -111000.0 -0.56 1123210.0 118425.0 0.651965144976402 0.4822 0.4257 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H01 compound treatment 847480.0 -1770.0 -0.01 793030.0 -218000.0 -1.09 832030.0 -172755.0 -0.951068090524791 -1.1849 -0.8186 1037188 Maybridge1_007019 CCc1cc(O)nc(S)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H02 compound treatment 27710.0 -822000.0 -4.69 32260.0 -979000.0 -4.9 31650.0 -973135.0 -5.35740005367626 -8.6294 -0.9984 1080220 Maybridge1_007020 CCc1cccc(CC)c1N2C(=O)C=CC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H03 compound treatment 753000.0 -96300.0 -0.55 789450.0 -222000.0 -1.11 733570.0 -271215.0 -1.49311992226958 -1.8198 -0.9383 2073130 Maybridge1_007021 CCCC1=NNC(=O)C1Cc2c(F)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H04 compound treatment 25630.0 -824000.0 -4.7 31960.0 -979000.0 -4.9 29470.0 -975315.0 -5.36940160753777 -8.644 -0.9984 2073131 Maybridge1_007022 Clc1ccc(N2C(=O)C=CC2=O)c(Br)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H05 compound treatment 723040.0 -126000.0 -0.72 706980.0 -304000.0 -1.52 785330.0 -219455.0 -1.20816559755792 -1.9922 -0.9614 1486875 Maybridge1_007023 CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H06 compound treatment 844110.0 -5140.0 -0.03 810690.0 -200000.0 -1.0 825700.0 -179085.0 -0.985916639122643 -1.1651 -0.8283 2073132 Maybridge1_007024 CC(C)c1ccc(NC(=O)/C=C/C(=O)O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H07 compound treatment 775050.0 -74200.0 -0.42 849380.0 -162000.0 -0.81 885280.0 -119505.0 -0.657910868907789 -1.0918 -0.9698 2073133 Maybridge1_007025 Nc1ccc(cc1)S(=O)(=O)Nc2cc(F)ccc2F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H08 compound treatment 846360.0 -2890.0 -0.02 824720.0 -186000.0 -0.93 836040.0 -168745.0 -0.928991837779548 -1.0843 -0.8237 1250169 Maybridge1_007026 COc1ccc(CCn2c(=O)c3cc4c(=O)n(CCc5ccc(OC)c(OC)c5)c(=O)c4cc3c2=O)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H09 compound treatment 990360.0 141000.0 0.81 780530.0 -231000.0 -1.15 932010.0 -72775.0 -0.400648202876569 -0.4319 -0.2952 1033953 Maybridge1_007027 O=C(CN1C(=O)c2ccccc2C1=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H10 compound treatment 509890.0 -339000.0 -1.94 611760.0 -399000.0 -2.0 514080.0 -490705.0 -2.70147820532527 -3.8323 -0.988 2073134 Maybridge1_007028 Clc1cc(NC(=S)NC(=O)c2ccccc2)ccc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H11 compound treatment 767780.0 -81500.0 -0.47 882600.0 -129000.0 -0.64 806120.0 -198665.0 -1.09371041187872 -1.2714 -0.9408 1006142 Maybridge1_007029 NC(=O)c1ccccc1C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H12 compound treatment 29560.0 -820000.0 -4.68 26950.0 -984000.0 -4.92 30120.0 -974665.0 -5.36582316257906 -8.6435 -0.9984 2073135 Maybridge1_007030 C/C(=C/c1cccc2ccccc12)/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H13 compound treatment 838310.0 -10900.0 -0.06 787000.0 -224000.0 -1.12 799900.0 -204885.0 -1.12795337748356 -1.3346 -0.8385 1594746 Maybridge1_007031 OCCNC(=S)NCc1ccccc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H14 compound treatment 1200370.0 351000.0 2.01 692810.0 -318000.0 -1.59 810190.0 -194595.0 -1.07130384113729 -0.3798 -0.1368 2073136 Maybridge1_007032 Sc1nc2cc(Cl)ccc2o1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H15 compound treatment 753730.0 -95500.0 -0.55 855170.0 -156000.0 -0.78 804910.0 -199875.0 -1.10037182480184 -1.4008 -0.9627 1113880 Maybridge1_007033 CCOc1ccc(NCN2C(=O)c3ccccc3C2=O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H16 compound treatment 49650.0 -800000.0 -4.57 97850.0 -913000.0 -4.57 125120.0 -879665.0 -4.84281966861446 -8.0705 -0.9996 2073137 Maybridge1_007034 C/C(=C\c1ccccc1[N+](=O)[O-])/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H17 compound treatment 897280.0 48000.0 0.27 822730.0 -188000.0 -0.94 839000.0 -165785.0 -0.912696149967599 -0.9127 -0.6809 1166307 Maybridge1_007035 Cc1ccc(NC(=S)NCCO)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H18 compound treatment 832880.0 -16400.0 -0.09 873240.0 -138000.0 -0.69 806240.0 -198545.0 -1.09304977588634 -1.0834 -0.836 1606002 Maybridge1_007036 O=C1N(CNc2ccc(cc2)N3CCOCC3)C(=O)c4ccccc14 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H19 compound treatment 850400.0 1150.0 0.01 787080.0 -224000.0 -1.12 847260.0 -157525.0 -0.86722237249236 -1.144 -0.8072 1653424 Maybridge1_007037 O=C1N(CNc2ccc(Oc3ccccc3)cc2)C(=O)c4ccccc14 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H20 compound treatment 790250.0 -59000.0 -0.34 764270.0 -247000.0 -1.23 832930.0 -171855.0 -0.946113320581969 -1.4538 -0.9133 2073138 Maybridge1_007038 Cc1cc(Br)ccc1NC(=S)Nc2ccc3ccccc3c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H21 compound treatment 27610.0 -822000.0 -4.69 31040.0 -980000.0 -4.9 27650.0 -977135.0 -5.37942125342214 -8.646 -0.9984 2073139 Maybridge1_007039 COc1ccc(Br)cc1/C=C/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H22 compound treatment 817080.0 -32200.0 -0.18 859160.0 -152000.0 -0.76 775490.0 -229295.0 -1.26233774893278 -1.2739 -0.8578 2073140 Maybridge1_007040 Cn1nc(O)c2ccccc2c1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H23 mock treatment 837600.0 -11700.0 -0.07 1034370.0 23200.0 0.12 870300.0 -134485.0 -0.740380261956103 -0.3989 -0.5302 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 H24 mock treatment 1130080.0 281000.0 1.6 1188450.0 177000.0 0.89 1010740.0 5955.0 0.032784061121676 1.457 0.7948 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I01 compound treatment 511600.0 -338000.0 -1.93 826720.0 -184000.0 -0.92 1122610.0 117825.0 0.648661965014521 -1.2717 -0.5692 1774525 Maybridge1_007041 OC(CNCc1ccccc1)c2ccc(cc2)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I02 compound treatment 622400.0 -227000.0 -1.3 1109220.0 98000.0 0.49 857010.0 -147775.0 -0.813545698111783 -0.9347 -0.5818 1332598 Maybridge1_007042 O=C(Cn1nnc(n1)N2CCCCC2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I03 compound treatment 660750.0 -189000.0 -1.08 875590.0 -136000.0 -0.68 863210.0 -141575.0 -0.779412838505672 -1.4632 -0.9805 2073141 Maybridge1_007043 OC(=O)c1ccc(o1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I04 compound treatment 631620.0 -218000.0 -1.24 764750.0 -246000.0 -1.23 845320.0 -159465.0 -0.877902654369111 -1.9362 -0.9887 2073142 Maybridge1_007044 Cc1nc(SCC(=O)C(C)(C)C)nc(O)c1CC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I05 compound treatment 580320.0 -269000.0 -1.54 684590.0 -327000.0 -1.63 736640.0 -268145.0 -1.47621865146462 -2.6823 -0.9991 1277061 Maybridge1_007045 COC(=O)c1ccccc1Sc2c(nc3ccccn23)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I06 compound treatment 722170.0 -127000.0 -0.73 791950.0 -219000.0 -1.1 857200.0 -147585.0 -0.812499691123854 -1.5213 -0.9842 2073143 Maybridge1_007046 CSc1ccccc1NC(=N)NC(=N)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I07 compound treatment 730730.0 -119000.0 -0.68 791600.0 -220000.0 -1.1 833120.0 -171665.0 -0.94506731359404 -1.5706 -0.9821 1211026 Maybridge1_007047 O=C(NC1CCN(Cc2ccccc2)CC1)C3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I08 compound treatment 738400.0 -111000.0 -0.63 875360.0 -136000.0 -0.68 894850.0 -109935.0 -0.605225148515776 -1.1072 -0.9989 2073144 Maybridge1_007048 NC(=N)NC(=N)Nc1nc(cs1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I09 compound treatment 725080.0 -124000.0 -0.71 854130.0 -157000.0 -0.79 886370.0 -118415.0 -0.651910091977038 -1.2394 -0.9971 1402258 Maybridge1_007049 COc1ccc(CCNC(=O)c2ccccc2Br)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I10 compound treatment 733760.0 -115000.0 -0.66 803710.0 -207000.0 -1.04 856160.0 -148625.0 -0.818225203057782 -1.4524 -0.9834 1202989 Maybridge1_007050 Nc1ncnc(Nc2ccc(Cl)c(Cl)c2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I11 compound treatment 807260.0 -42000.0 -0.24 847810.0 -163000.0 -0.82 906020.0 -98765.0 -0.543730948225412 -0.9242 -0.9147 2073145 Maybridge1_007051 FC(F)(F)c1cc(cc(c1)S(=O)(=O)N2CCN(Cc3ccccc3)CC2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I12 compound treatment 15780.0 -833000.0 -4.76 20820.0 -990000.0 -4.95 19800.0 -984985.0 -5.42263785792343 -8.7394 -0.9985 2073146 Maybridge1_007052 NC(=N)NC(=N)Nc1ccc(Cl)cc1C(=O)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I13 compound treatment 727780.0 -121000.0 -0.69 784040.0 -227000.0 -1.14 784050.0 -220735.0 -1.2152123814766 -1.7581 -0.9754 2073147 Maybridge1_007053 CC(C)(C)n1nn[nH]c1=S 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I14 compound treatment 739300.0 -110000.0 -0.63 865820.0 -145000.0 -0.73 857480.0 -147305.0 -0.810958207141642 -1.2506 -0.9947 2073148 Maybridge1_007054 OC(=O)CCNC(=S)Nc1ccccc1C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I15 compound treatment 716180.0 -133000.0 -0.76 779700.0 -231000.0 -1.16 858280.0 -146505.0 -0.806553967192466 -1.573 -0.9814 2073149 Maybridge1_007055 CCCCCSc1nnc[nH]1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I16 compound treatment 620480.0 -229000.0 -1.31 706880.0 -304000.0 -1.52 725240.0 -279545.0 -1.53897907074037 -2.5217 -0.9974 2073150 Maybridge1_007056 Clc1ccccc1Nc2ncnc(n2)n3cccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I17 compound treatment 791330.0 -57900.0 -0.33 837440.0 -174000.0 -0.87 870120.0 -134665.0 -0.741371215944667 -1.1207 -0.9424 1071543 Maybridge1_007057 c1cc2cc3ccccc3cc2s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I18 compound treatment 806300.0 -43000.0 -0.25 831360.0 -180000.0 -0.9 894100.0 -110685.0 -0.609354123468128 -1.0127 -0.9093 2073151 Maybridge1_007058 CCCCc1c(O)nc(S)nc1COC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I19 compound treatment 907760.0 58500.0 0.33 784740.0 -226000.0 -1.13 863220.0 -141565.0 -0.779357785506307 -0.9109 -0.6438 2073152 Maybridge1_007059 CCOC(=O)c1c(/N=C/c2cc(Br)c(Br)cc2O)sc3CCCCc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I20 compound treatment 812050.0 -37200.0 -0.21 821500.0 -190000.0 -0.95 843390.0 -161395.0 -0.888527883246498 -1.1834 -0.8985 1181266 Maybridge1_007060 COCc1cc(=O)oc2cc(N)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I21 compound treatment 670990.0 -178000.0 -1.02 728410.0 -283000.0 -1.41 691360.0 -313425.0 -1.72549863258796 -2.4007 -0.9789 2073153 Maybridge1_007061 NC(=N)NC(=N)Nc1cc(Cl)cc(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I22 compound treatment 427520.0 -422000.0 -2.41 377950.0 -633000.0 -3.17 573140.0 -431645.0 -2.37633519107738 -4.5914 -0.9906 2073154 Maybridge1_007062 NC(=N)NC(=N)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I23 mock treatment 847690.0 -1560.0 -0.01 867360.0 -144000.0 -0.72 902760.0 -102025.0 -0.561678226018302 -0.7447 -0.816 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 I24 mock treatment 1068800.0 220000.0 1.25 1169040.0 158000.0 0.79 998400.0 -6385.0 -0.0351513400943579 1.1597 0.7823 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J01 compound treatment 737120.0 -112000.0 -0.64 898240.0 -113000.0 -0.56 808250.0 -196535.0 -1.08198412301404 -1.3206 -0.9581 2073155 Maybridge1_007063 CCc1cc(O)nc(SCc2c(F)cccc2Cl)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J02 compound treatment 587560.0 -262000.0 -1.49 630440.0 -381000.0 -1.9 586100.0 -418685.0 -2.30498650390074 -3.2933 -0.9852 1434301 Maybridge1_007064 CCc1cccc(CC)c1N2C(=O)CC(Sc3ccccc3N)C2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J03 compound treatment 458040.0 -391000.0 -2.23 467420.0 -544000.0 -2.72 563810.0 -440975.0 -2.42769963948464 -4.2621 -0.9967 1237906 Maybridge1_007065 CCCC1=NN(C(=O)c2ccc(Cl)cc2)C(=O)C1Cc3c(F)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J04 compound treatment 733120.0 -116000.0 -0.66 765810.0 -245000.0 -1.23 756980.0 -247805.0 -1.36424085075683 -1.8792 -0.9631 1056222 Maybridge1_007066 Cc1ccc(C=C(C#N)C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J05 compound treatment 787450.0 -61800.0 -0.35 769070.0 -242000.0 -1.21 815040.0 -189745.0 -1.04460313644541 -1.506 -0.9196 2073156 Maybridge1_007067 COCc1cc(O)nc(SCC2CC2)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J06 compound treatment 723000.0 -126000.0 -0.72 750650.0 -261000.0 -1.3 743370.0 -261415.0 -1.43916798289218 -1.9996 -0.9655 1084580 Maybridge1_007068 Nc1ccccc1SC(CC(=O)c2ccccc2)c3ccc4OCOc4c3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J07 compound treatment 784840.0 -64400.0 -0.37 811800.0 -199000.0 -1.0 836690.0 -168095.0 -0.925413392820843 -1.3224 -0.9384 2073157 Maybridge1_007069 FC(F)(F)c1cccc(c1)c2nn[nH]n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J08 compound treatment 730140.0 -119000.0 -0.68 775120.0 -236000.0 -1.18 755650.0 -249135.0 -1.37156289967233 -1.8664 -0.9653 1928 Maybridge1_007070 [O-][N+](=O)c1ccc(C=C(C#N)C#N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J09 compound treatment 751410.0 -97800.0 -0.56 840960.0 -170000.0 -0.85 765030.0 -239755.0 -1.31992318626825 -1.5763 -0.9455 2073158 Maybridge1_007071 Cc1cccc(/N=C/c2cc(I)cc(I)c2O)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J10 compound treatment 263090.0 -586000.0 -3.35 286010.0 -725000.0 -3.63 261670.0 -743115.0 -4.09107096228954 -6.3892 -0.9966 2073159 Maybridge1_007072 COc1cc(NC(=S)NC(=O)c2ccccc2)c(OC)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J11 compound treatment 707080.0 -142000.0 -0.81 782660.0 -229000.0 -1.14 781170.0 -223615.0 -1.23106764529363 -1.8395 -0.9859 1006360 Maybridge1_007073 Oc1nnc(O)c2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J12 compound treatment 21020.0 -828000.0 -4.73 27520.0 -984000.0 -4.92 23100.0 -981685.0 -5.40447036813308 -8.6923 -0.9984 1921383 Maybridge1_007074 C/C(=C\c1ccc(Cl)cc1)/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J13 compound treatment 796730.0 -52500.0 -0.3 1200370.0 189000.0 0.95 876090.0 -128695.0 -0.708504575323944 -0.0359 -0.0295 1042465 Maybridge1_007075 OCCNC(=S)NCC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J14 compound treatment 801290.0 -48000.0 -0.27 826990.0 -184000.0 -0.92 833640.0 -171145.0 -0.942204557627075 -1.234 -0.9169 2073160 Maybridge1_007076 C/C(=N\Cc1ccncc1)/c2ccccc2O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J15 compound treatment 839150.0 -10100.0 -0.06 826940.0 -184000.0 -0.92 851780.0 -153005.0 -0.842338416779518 -1.0516 -0.8415 2073161 Maybridge1_007077 O=C/1OC(=N\C1=C/c2ccc(cc2)c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J16 compound treatment 809760.0 -39500.0 -0.23 804120.0 -207000.0 -1.04 796660.0 -208125.0 -1.14579054927772 -1.3897 -0.8903 2073162 Maybridge1_007078 COc1cc(/C=N/CCC\N=C\c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J17 compound treatment 871200.0 22000.0 0.13 919000.0 -92200.0 -0.46 853890.0 -150895.0 -0.830722233913568 -0.6734 -0.7027 1018228 Maybridge1_007079 Nc1c(C#N)c(CC#N)nn1c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J18 compound treatment 793050.0 -56200.0 -0.32 1058090.0 46900.0 0.23 788710.0 -216075.0 -1.18955768377265 -0.7367 -0.5873 2073163 Maybridge1_007080 Oc1ccc(Br)cc1/C=N/c2ccc(cc2)S(=O)(=O)Nc3nccs3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J19 compound treatment 756500.0 -92800.0 -0.53 823940.0 -187000.0 -0.94 799140.0 -205645.0 -1.13213740543527 -1.5002 -0.9605 1259024 Maybridge1_007081 Clc1ccc(NC(=S)Nc2ccccn2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J20 compound treatment 689370.0 -160000.0 -0.91 710650.0 -301000.0 -1.5 723040.0 -281745.0 -1.5510907306006 -2.2906 -0.9768 2073164 Maybridge1_007082 COC(=O)c1ccccc1N=NNc2cc(OC)cc(c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J21 compound treatment 795520.0 -53700.0 -0.31 807040.0 -204000.0 -1.02 871890.0 -132895.0 -0.731626835057116 -1.1891 -0.9196 2073165 Maybridge1_007083 COc1ccc(Br)cc1/C=N/N=C/c2cc(Br)ccc2OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J22 compound treatment 787880.0 -61400.0 -0.35 845610.0 -166000.0 -0.83 850850.0 -153935.0 -0.847458345720435 -1.1698 -0.9467 1524469 Maybridge1_007084 O=C1N(Nc2ccccc2)C(=O)c3cccc4cccc1c34 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J23 mock treatment 861780.0 12500.0 0.07 906900.0 -104000.0 -0.52 861660.0 -143125.0 -0.787946053407199 -0.7147 -0.7542 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 J24 mock treatment 1178080.0 329000.0 1.88 1145280.0 134000.0 0.67 1044290.0 39505.0 0.217486873990228 1.5973 0.7961 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K01 compound treatment 688760.0 -160000.0 -0.92 910790.0 -100000.0 -0.5 1072240.0 67455.0 0.371360007214551 -0.6048 -0.5452 1050488 Maybridge1_007085 OC(=O)CCCNc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K02 compound treatment 595000.0 -254000.0 -1.45 734680.0 -276000.0 -1.38 927650.0 -77135.0 -0.424651310599576 -1.8821 -0.9181 1267668 Maybridge1_007086 Fc1cccc(Cl)c1Cn2nnc(n2)N3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K03 compound treatment 443840.0 -405000.0 -2.32 661710.0 -349000.0 -1.75 789920.0 -214865.0 -1.18289627084952 -3.0292 -0.9668 2073166 Maybridge1_007087 CC/1(CCCC\C1=N\O)NO 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K04 compound treatment 655520.0 -194000.0 -1.11 766980.0 -244000.0 -1.22 872000.0 -132785.0 -0.731021252064105 -1.7661 -0.9796 2073167 Maybridge1_007088 Cc1cc(O)nc(SCC(=O)C(C)(C)C)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K05 compound treatment 674020.0 -175000.0 -1.0 885470.0 -126000.0 -0.63 884910.0 -119875.0 -0.659947829884283 -1.3219 -0.9765 2073168 Maybridge1_007089 OC(=O)C1(CC2CC3C1)CC(C2)(C3)C(F)(F)C(F)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K06 compound treatment 659070.0 -190000.0 -1.09 1009840.0 -1330.0 -0.01 904350.0 -100435.0 -0.552924799119316 -0.9503 -0.7796 2073169 Maybridge1_007090 Cc1cccc(NC(=N)NC(=N)N)c1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K07 compound treatment 611320.0 -238000.0 -1.36 776400.0 -235000.0 -1.17 805860.0 -198925.0 -1.0951417898622 -2.0949 -0.9958 1627929 Maybridge1_007091 Clc1ccc(cc1)C(=O)NC2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K08 compound treatment 652830.0 -196000.0 -1.12 707520.0 -304000.0 -1.52 825540.0 -179245.0 -0.986797487112478 -2.0944 -0.983 2073170 Maybridge1_007092 NC(=N)NC(=N)Nc1cc(Cl)ccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K09 compound treatment 648530.0 -201000.0 -1.15 759010.0 -252000.0 -1.26 839010.0 -165775.0 -0.912641096968234 -1.9171 -0.9915 1202748 Maybridge1_007093 COc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K10 compound treatment 639680.0 -210000.0 -1.2 761760.0 -249000.0 -1.25 819920.0 -184865.0 -1.01773727275544 -1.999 -0.9964 2073171 Maybridge1_007094 Cc1cc(NC(=N)NC(=N)N)ccc1Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K11 compound treatment 696560.0 -153000.0 -0.87 877840.0 -133000.0 -0.67 865640.0 -139145.0 -0.766034959660051 -1.3309 -0.9941 1729064 Maybridge1_007095 Clc1cc(Cl)c(cc1Cl)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K12 compound treatment 728340.0 -121000.0 -0.69 815640.0 -196000.0 -0.98 837520.0 -167265.0 -0.920843993873574 -1.4951 -0.9898 2073172 Maybridge1_007096 Oc1cc(nc(n1)C2CC2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K13 compound treatment 28160.0 -821000.0 -4.69 37020.0 -974000.0 -4.87 31780.0 -973005.0 -5.35668436468452 -8.6137 -0.9984 2073173 Maybridge1_007097 CC1=CC(=O)C(=CC1=O)Br 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K14 compound treatment 678250.0 -171000.0 -0.98 784960.0 -226000.0 -1.13 887210.0 -117575.0 -0.647285640030403 -1.5909 -0.9767 1137690 Maybridge1_007098 OC(=O)CCNC(=S)Nc1cccc(F)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K15 compound treatment 646590.0 -203000.0 -1.16 729290.0 -282000.0 -1.41 813760.0 -191025.0 -1.05164992036409 -2.0895 -0.9923 2073174 Maybridge1_007099 C1c2ccccc2-c3ncccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K16 compound treatment 639050.0 -210000.0 -1.2 707780.0 -303000.0 -1.52 781760.0 -223025.0 -1.22781951833111 -2.2782 -0.9941 1013598 Maybridge1_007100 NC(=N)NC(=N)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K17 compound treatment 689550.0 -160000.0 -0.91 823320.0 -188000.0 -0.94 856160.0 -148625.0 -0.818225203057782 -1.5416 -0.9983 724 Maybridge1_007101 CCn1cc(C(=O)O)c(=O)c2ccc(C)nc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K18 compound treatment 713510.0 -136000.0 -0.78 854880.0 -156000.0 -0.78 908480.0 -96305.0 -0.530187910381697 -1.2051 -0.9861 2073175 Maybridge1_007102 CCSc1nc(N)c(Br)c(O)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K19 compound treatment 555700.0 -294000.0 -1.68 678670.0 -333000.0 -1.66 745120.0 -259665.0 -1.42953370800336 -2.7537 -0.9975 1037873 Maybridge1_007103 Cc1c(cc2c(c1[N+](=O)[O-])C(C)(C)CC2(C)C)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K20 compound treatment 737370.0 -112000.0 -0.64 850310.0 -161000.0 -0.8 920520.0 -84265.0 -0.463904099146604 -1.1013 -0.9769 1208794 Maybridge1_007104 CC1=CC2N=C(C)C=C(O)N2O1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K21 compound treatment 756170.0 -93100.0 -0.53 811810.0 -199000.0 -1.0 885960.0 -118825.0 -0.65416726495099 -1.2604 -0.9653 2073176 Maybridge1_007105 Cc1nc(S)nc(O)c1Cc2c(F)cccc2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K22 compound treatment 905280.0 56000.0 0.32 829830.0 -181000.0 -0.91 981970.0 -22815.0 -0.125603418050552 -0.4114 -0.4241 1027920 Maybridge1_007106 CC1=CC(C)(C)NC(=S)N1c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K23 mock treatment 787360.0 -61900.0 -0.35 868810.0 -142000.0 -0.71 958280.0 -46505.0 -0.256023973545515 -0.763 -0.9136 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 K24 mock treatment 837770.0 -11500.0 -0.07 1172270.0 161000.0 0.81 1087610.0 82825.0 0.455976467238088 0.6906 0.7441 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L01 compound treatment 992320.0 143000.0 0.82 852030.0 -159000.0 -0.8 923520.0 -81265.0 -0.447388199337195 -0.246 -0.2007 1659710 Maybridge1_007107 COc1ccccc1NC(=S)NCCC(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L02 compound treatment 751460.0 -97800.0 -0.56 1041000.0 29800.0 0.15 789830.0 -214955.0 -1.1833917478438 -0.9196 -0.6982 1080211 Maybridge1_007108 CCc1cccc(CC)c1NC(=S)N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L03 compound treatment 785600.0 -63700.0 -0.36 1052360.0 41200.0 0.21 828610.0 -176175.0 -0.969896216307517 -0.651 -0.6164 2073177 Maybridge1_007109 CCCC1=NNC(=O)C1CC=C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L04 compound treatment 779050.0 -70200.0 -0.4 729600.0 -282000.0 -1.41 827780.0 -177005.0 -0.974465615254787 -1.6072 -0.9138 1002383 Maybridge1_007110 N#CC(=Cc1ccc2OCOc2c1)C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L05 compound treatment 236160.0 -613000.0 -3.5 313870.0 -697000.0 -3.49 335550.0 -669235.0 -3.68433940298318 -6.1628 -0.9997 2073178 Maybridge1_007111 CCCc1nc(nc(O)c1CC2CC2)c3ccccn3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L06 compound treatment 789730.0 -59500.0 -0.34 869120.0 -142000.0 -0.71 885960.0 -118825.0 -0.65416726495099 -0.9842 -0.9612 1604878 Maybridge1_007112 COc1cccc(Nc2nnc(S)s2)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L07 compound treatment 691780.0 -157000.0 -0.9 802580.0 -209000.0 -1.04 725670.0 -279115.0 -1.53661179176769 -2.0089 -0.9734 2073179 Maybridge1_007113 FC(F)(F)c1cccc(c1)c2nnc(o2)c3ccc(Cl)cc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L08 compound treatment 722330.0 -127000.0 -0.73 866090.0 -145000.0 -0.73 802950.0 -201835.0 -1.11116221267732 -1.4791 -0.9781 2073180 Maybridge1_007114 COc1cccc(/C=N/N=C/c2cccc(OC)c2O)c1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L09 compound treatment 685490.0 -164000.0 -0.94 734480.0 -277000.0 -1.38 786050.0 -218735.0 -1.20420178160366 -2.0343 -0.9879 2073181 Maybridge1_007115 Oc1c(Br)cc(Br)cc1/C=N/c2ccc(Oc3ccc(Cl)cc3)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L10 compound treatment 725360.0 -124000.0 -0.71 845550.0 -166000.0 -0.83 791700.0 -213085.0 -1.17309683696261 -1.5642 -0.977 2073182 Maybridge1_007116 C/C(=N\Cc1ccc2OCOc2c1)/c3ccccc3O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L11 compound treatment 684690.0 -165000.0 -0.94 832910.0 -178000.0 -0.89 761920.0 -242865.0 -1.33704466907067 -1.8294 -0.9826 1084579 Maybridge1_007117 Clc1ccc(Oc2ccc(NCN3C(=O)c4ccccc4C3=O)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L12 compound treatment 767210.0 -82000.0 -0.47 873610.0 -138000.0 -0.69 861520.0 -143265.0 -0.788716795398305 -1.1232 -0.9794 1012383 Maybridge1_007118 NC(=O)Nc1ccc(Cl)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L13 compound treatment 823840.0 -25400.0 -0.15 1054450.0 43300.0 0.22 923040.0 -81745.0 -0.450030743306701 -0.2187 -0.4205 1183837 Maybridge1_007119 CCOC(=O)c1ccc(NCN2C(=O)c3ccccc3C2=O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L14 compound treatment 24010.0 -825000.0 -4.71 28220.0 -983000.0 -4.92 26130.0 -978655.0 -5.38778930932557 -8.6708 -0.9984 2073183 Maybridge1_007120 CCOc1ccc(Br)cc1/C=C(\C)/[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L15 compound treatment 19200.0 -830000.0 -4.74 21310.0 -990000.0 -4.95 25160.0 -979625.0 -5.39312945026395 -8.7097 -0.9985 2073184 Maybridge1_007121 [O-][N+](=O)/C=C/c1c(Cl)cccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L16 compound treatment 568360.0 -281000.0 -1.6 611230.0 -400000.0 -2.0 655320.0 -349465.0 -1.92390964229832 -3.1921 -0.9957 2073185 Maybridge1_007122 C/C(=N\NC(=S)N)/c1ccc(Br)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L17 compound treatment 688120.0 -161000.0 -0.92 802100.0 -209000.0 -1.05 786780.0 -218005.0 -1.20018291265004 -1.8281 -0.9942 2073186 Maybridge1_007123 O=C/1OC(=N\C1=C/c2ccco2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L18 compound treatment 814660.0 -34600.0 -0.2 824160.0 -187000.0 -0.94 897400.0 -107385.0 -0.591186633677779 -0.9954 -0.8856 1569211 Maybridge1_007124 COc1ccc(cc1)C(=O)CC2OC(=O)c3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L19 compound treatment 676880.0 -172000.0 -0.98 895240.0 -116000.0 -0.58 814880.0 -189905.0 -1.04548398443524 -1.5069 -0.9729 1045646 Maybridge1_007125 Cc1ccc(CSC(=N)N)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L20 compound treatment 802970.0 -46300.0 -0.26 805220.0 -206000.0 -1.03 876380.0 -128405.0 -0.706908038342368 -1.1555 -0.9049 2073187 Maybridge1_007126 CN(C)c1ccc(cc1)n2nnnc2S 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L21 compound treatment 759220.0 -90000.0 -0.51 892440.0 -119000.0 -0.59 908450.0 -96335.0 -0.530353069379791 -0.946 -0.998 1384061 Maybridge1_007127 Sc1nnc(NC2CCCCC2)s1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L22 compound treatment 722090.0 -127000.0 -0.73 808100.0 -203000.0 -1.02 854310.0 -150475.0 -0.82841000794025 -1.4841 -0.9904 1040878 Maybridge1_007128 CN(C)N1C(=O)c2ccccc2C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L23 mock treatment 772800.0 -76500.0 -0.44 860340.0 -151000.0 -0.75 1014900.0 10115.0 0.0556861088573892 -0.6555 -0.7505 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 L24 mock treatment 709410.0 -140000.0 -0.8 1074140.0 63000.0 0.31 942310.0 -62475.0 -0.343943613530933 -0.478 -0.5167 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M01 compound treatment 719690.0 -130000.0 -0.74 793920.0 -217000.0 -1.09 1003440.0 -1345.0 -0.0074046284145515 -1.0589 -0.8054 1153336 Maybridge1_007129 S(c1c(nc2ccccn12)c3ccccc3)c4ccccc4 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M02 compound treatment 646000.0 -203000.0 -1.16 881330.0 -130000.0 -0.65 1008380.0 3595.0 0.0197915532716079 -1.0339 -0.7771 1304742 Maybridge1_007130 Cc1nc(SCc2c(F)cccc2Cl)nc(O)c1Cc3c(F)cccc3Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M03 compound treatment 644000.0 -205000.0 -1.17 756650.0 -255000.0 -1.27 895840.0 -108945.0 -0.599774901578671 -1.7582 -0.9599 2073188 Maybridge1_007131 Cc1cnnc2ccc3nonc3c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M04 compound treatment 610830.0 -238000.0 -1.36 866920.0 -144000.0 -0.72 839900.0 -164885.0 -0.907741380024776 -1.727 -0.9655 2073189 Maybridge1_007132 CCOC(=N)c1ccc(F)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M05 compound treatment 653540.0 -196000.0 -1.12 746880.0 -264000.0 -1.32 815750.0 -189035.0 -1.04069437349052 -2.0095 -0.9948 1652029 Maybridge1_007133 Clc1ccc(CN2CCC(CC2)NC(=O)c3ccccc3)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M06 compound treatment 768560.0 -80700.0 -0.46 874440.0 -137000.0 -0.68 1051170.0 46385.0 0.255363337553139 -0.5135 -0.5948 2073190 Maybridge1_007134 Nc1ncnc(Nc2cccc(c2)C(F)(F)F)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M07 compound treatment 687430.0 -162000.0 -0.92 834520.0 -177000.0 -0.88 860660.0 -144125.0 -0.793451353343669 -1.5019 -0.998 1684864 Maybridge1_007135 Brc1ccccc1C(=O)NC2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M08 compound treatment 708410.0 -141000.0 -0.8 812340.0 -199000.0 -0.99 864520.0 -140265.0 -0.772200895588897 -1.4845 -0.9935 2073191 Maybridge1_007136 CCOC(=N)c1cccc(c1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M09 compound treatment 675900.0 -173000.0 -0.99 828560.0 -183000.0 -0.91 858520.0 -146265.0 -0.805232695207714 -1.564 -0.9965 1607644 Maybridge1_007137 COc1ccc(CCNS(=O)(=O)c2ccc(Cl)c(Cl)c2Cl)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M10 compound treatment 637930.0 -211000.0 -1.21 673150.0 -338000.0 -1.69 706300.0 -298485.0 -1.6432494515371 -2.6218 -0.9898 2073192 Maybridge1_007138 NC(=N)NC(=N)Nc1ccc(Oc2ccc(Cl)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M11 compound treatment 829980.0 -19300.0 -0.11 851690.0 -159000.0 -0.8 985870.0 -18915.0 -0.104132748298321 -0.5842 -0.7195 1513968 Maybridge1_007139 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M12 compound treatment 660930.0 -188000.0 -1.08 942010.0 -69200.0 -0.35 861810.0 -142975.0 -0.787120258416729 -1.2753 -0.926 1471831 Maybridge1_007140 CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2cc(Cl)cc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M13 compound treatment 738170.0 -111000.0 -0.63 834010.0 -177000.0 -0.89 1000000.0 -4785.0 -0.0263428601960066 -0.8932 -0.8193 686 Maybridge1_007141 C(Nc1ncnc2[nH]cnc12)c3ccco3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M14 compound treatment 719040.0 -130000.0 -0.74 863440.0 -148000.0 -0.74 787220.0 -217565.0 -1.19776058067799 -1.5476 -0.9722 1022398 Maybridge1_007142 Nc1ccc(cc1)S(=O)(=O)Nc2cccc(c2)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M15 compound treatment 618560.0 -231000.0 -1.32 766790.0 -244000.0 -1.22 824600.0 -180185.0 -0.99197246905276 -2.0393 -0.9933 1074320 Maybridge1_007143 O=C1c2ccccc2-c3ncccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M16 compound treatment 743320.0 -106000.0 -0.61 1054570.0 43400.0 0.22 932850.0 -71935.0 -0.396023750929935 -0.4527 -0.5996 2073193 Maybridge1_007144 CC(C)CCc1c(C)nc(SCC(=O)C(C)(C)C)nc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M17 compound treatment 706980.0 -142000.0 -0.81 763170.0 -248000.0 -1.24 890080.0 -114705.0 -0.631485429212736 -1.55 -0.9616 1644993 Maybridge1_007145 Cc1nn(c(N)c1c2ccccc2)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M18 compound treatment 671200.0 -178000.0 -1.02 790880.0 -220000.0 -1.1 820870.0 -183915.0 -1.01250723781579 -1.8079 -0.9992 2073194 Maybridge1_007146 NC(=N)NC(=N)Nc1ccc2OCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M19 compound treatment 745600.0 -104000.0 -0.59 769180.0 -242000.0 -1.21 937410.0 -67375.0 -0.370919583219634 -1.2548 -0.8979 2073195 Maybridge1_007147 Cc1cc(O)n(n1)c2cc(Cl)c(cc2Cl)S(=O)(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M20 compound treatment 710880.0 -138000.0 -0.79 859760.0 -151000.0 -0.76 910200.0 -94585.0 -0.520718794490969 -1.1942 -0.9852 2073196 Maybridge1_007148 Cc1cc(O)nc(n1)c2cccc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M21 compound treatment 739200.0 -110000.0 -0.63 816090.0 -195000.0 -0.98 915520.0 -89265.0 -0.491430598828951 -1.21 -0.96 2073197 Maybridge1_007149 COc1ccc(CCN/2C(=O)CS\C2=N/c3cc(Cl)cc(Cl)c3)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M22 compound treatment 689820.0 -159000.0 -0.91 939380.0 -71800.0 -0.36 871840.0 -132945.0 -0.73190210005394 -1.1557 -0.9455 2073198 Maybridge1_007150 COCc1cc(=O)oc2[nH]nc(C)c12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M23 mock treatment 762310.0 -86900.0 -0.5 891250.0 -120000.0 -0.6 999090.0 -5695.0 -0.0313526831381939 -0.6511 -0.8355 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 M24 mock treatment 801240.0 -48000.0 -0.27 1089530.0 78400.0 0.39 903360.0 -101425.0 -0.558375046056421 -0.2545 -0.3461 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N01 compound treatment 821440.0 -27800.0 -0.16 780090.0 -231000.0 -1.16 867390.0 -137395.0 -0.756400684771229 -1.1957 -0.86 2073199 Maybridge1_007151 [O-][N+](=O)c1cccc(c1)c2nn[nH]n2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N02 compound treatment 886780.0 37500.0 0.21 1002940.0 -8230.0 -0.04 825300.0 -179485.0 -0.988118759097231 -0.4705 -0.4649 2073200 Maybridge1_007152 Sc1nnnn1Cc2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N03 compound treatment 815930.0 -33300.0 -0.19 945230.0 -65900.0 -0.33 829210.0 -175575.0 -0.966593036345635 -0.8584 -0.8262 1205916 Maybridge1_007153 CCCc1cc(=O)oc2cc(OCC(=O)OCC)ccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N04 compound treatment 919590.0 70300.0 0.4 1090570.0 79400.0 0.4 835240.0 -169545.0 -0.933396077728724 -0.0776 -0.0712 2073201 Maybridge1_007154 Cc1cc(C)c(NC(=S)NN)c(C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N05 compound treatment 876000.0 26800.0 0.15 812640.0 -199000.0 -0.99 901370.0 -103415.0 -0.569330592929995 -0.8138 -0.7047 1694603 Maybridge1_007155 CC(C(=O)NN)n1nnc(n1)N2CCOCC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N06 compound treatment 704100.0 -145000.0 -0.83 758770.0 -252000.0 -1.26 785530.0 -219255.0 -1.20706453757062 -1.9045 -0.985 1058453 Maybridge1_007156 N#CC(=Cc1c[nH]c2ccccc12)C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N07 compound treatment 823200.0 -26100.0 -0.15 1038430.0 27300.0 0.14 902320.0 -102465.0 -0.564100557990349 -0.3329 -0.5556 1643270 Maybridge1_007157 NNC(=O)CCn1nnc(n1)c2cccc(Cl)c2Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N08 compound treatment 721510.0 -128000.0 -0.73 767680.0 -243000.0 -1.22 830510.0 -174275.0 -0.959436146428225 -1.6784 -0.9795 2073202 Maybridge1_007158 CCO/C=C/1\SC(=S)NC1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N09 compound treatment 615920.0 -233000.0 -1.33 706430.0 -305000.0 -1.52 715920.0 -288865.0 -1.59028846614827 -2.5677 -0.9973 2073203 Maybridge1_007159 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccccc2C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N10 compound treatment 769120.0 -80100.0 -0.46 845760.0 -165000.0 -0.83 838510.0 -166275.0 -0.915393746936469 -1.2704 -0.9654 2073204 Maybridge1_007160 CCOC(=O)c1ccc(NC(=S)NCCCN2CCOCC2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N11 compound treatment 828480.0 -20800.0 -0.12 933120.0 -78100.0 -0.39 805410.0 -199375.0 -1.09761917483361 -0.9276 -0.7921 1487751 Maybridge1_007161 Cc1ccccc1NC(=S)NCCO 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N12 compound treatment 771630.0 -77600.0 -0.44 1029490.0 18300.0 0.09 831360.0 -173425.0 -0.954756641482226 -0.7543 -0.7139 2073205 Maybridge1_007162 O=C/1OC(=N\C1=C/c2ccc(\C=C\3/N=C(OC3=O)c4ccccc4)cc2)c5ccccc5 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N13 compound treatment 794740.0 -54500.0 -0.31 1082270.0 71100.0 0.36 834650.0 -170135.0 -0.936644204691241 -0.5152 -0.4911 1264587 Maybridge1_007163 Cc1cccc(C)c1NC(=S)NCCO 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N14 compound treatment 753290.0 -96000.0 -0.55 807700.0 -203000.0 -1.02 772210.0 -232575.0 -1.2803951327244 -1.6433 -0.9526 2073206 Maybridge1_007164 COc1ccccc1C=C(C#N)C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N15 compound treatment 800970.0 -48300.0 -0.28 976600.0 -34600.0 -0.17 835590.0 -169195.0 -0.93146922275096 -0.7969 -0.8076 2073207 Maybridge1_007165 Clc1ccc(/C=C/2\N=C(OC2=O)c3ccccc3)c(Cl)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N16 compound treatment 740590.0 -109000.0 -0.62 811800.0 -199000.0 -1.0 809370.0 -195415.0 -1.07581818708519 -1.5552 -0.9764 1056276 Maybridge1_007166 NC1=C(C#N)C2=CCCC2C3(CCCC3)C1(C#N)C#N 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N17 compound treatment 865810.0 16600.0 0.09 857120.0 -154000.0 -0.77 949630.0 -55155.0 -0.303644817995976 -0.5656 -0.6785 2073208 Maybridge1_007167 Cc1cc(CSC(=N)N)c(CSC(=N)N)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N18 compound treatment 745690.0 -104000.0 -0.59 828850.0 -182000.0 -0.91 829600.0 -175185.0 -0.964445969370412 -1.4249 -0.9805 2073209 Maybridge1_007168 CCCCC(C(=O)N/N=C/c1ccc(OCC)c(OC)c1)C(=O)N/N=C/c2ccc(OCC)c(OC)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N19 compound treatment 778320.0 -70900.0 -0.41 810140.0 -201000.0 -1.01 895540.0 -109245.0 -0.601426491559612 -1.1617 -0.9371 1719191 Maybridge1_007169 Cc1ccc(NC(=S)Nc2ccccn2)cc1C 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N20 compound treatment 750590.0 -98700.0 -0.56 993230.0 -17900.0 -0.09 829640.0 -175145.0 -0.964225757372953 -0.9339 -0.8335 1506578 Maybridge1_007170 NNC(=S)Nc1ccc2OCCOc2c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N21 compound treatment 765120.0 -84100.0 -0.48 892910.0 -118000.0 -0.59 828190.0 -176595.0 -0.972208442280834 -1.1803 -0.9554 1239520 Maybridge1_007171 COc1ccc(CCNC(=S)NCCc2ccc(OC)c(OC)c2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N22 compound treatment 753080.0 -96200.0 -0.55 813330.0 -198000.0 -0.99 885760.0 -119025.0 -0.655268324938284 -1.2668 -0.9686 2073210 Maybridge1_007172 COc1ccc(CC/N=C(\C)/c2ccc3ccccc3c2)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N23 mock treatment 842800.0 -6450.0 -0.04 1194980.0 184000.0 0.92 1066280.0 61495.0 0.338548419593193 0.705 0.7191 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 N24 mock treatment 820240.0 -29000.0 -0.17 1097460.0 86300.0 0.43 1033170.0 28385.0 0.156267938696687 0.2437 0.4994 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O01 compound treatment 467460.0 -382000.0 -2.18 882880.0 -128000.0 -0.64 947840.0 -56945.0 -0.313499304882257 -1.8106 -0.789 1278108 Maybridge1_007173 OC(=O)c1nonc1c2nonc2C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O02 compound treatment 590680.0 -259000.0 -1.48 926680.0 -84500.0 -0.42 1069710.0 64925.0 0.357431598375283 -0.8904 -0.5645 2073211 Maybridge1_007174 S=C(NCc1cccs1)NC2CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O03 compound treatment 632440.0 -217000.0 -1.24 959040.0 -52100.0 -0.26 925190.0 -79595.0 -0.438194348443291 -1.1186 -0.8352 1922564 Maybridge1_007175 c1ccc(cc1)c2cc3c4nonc4ccc3nn2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O04 compound treatment 218500.0 -631000.0 -3.6 500010.0 -511000.0 -2.56 582500.0 -422285.0 -2.32480558367203 -4.8986 -0.9812 1679982 Maybridge1_007176 Cc1nc(nc(O)c1CC2CC2)c3ccccn3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O05 compound treatment 570510.0 -279000.0 -1.59 795490.0 -216000.0 -1.08 832910.0 -171875.0 -0.946223426580698 -2.0884 -0.9743 1426502 Maybridge1_007177 Clc1ccc(CN2CCC(CC2)NC(=O)c3ccccc3)cc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O06 compound treatment 603520.0 -246000.0 -1.4 876680.0 -134000.0 -0.67 865710.0 -139075.0 -0.765649588664498 -1.6409 -0.9459 2073212 Maybridge1_007178 NC(=N)NC(=N)Nc1cccc(C#C)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O07 compound treatment 713350.0 -136000.0 -0.78 1048740.0 37600.0 0.19 942510.0 -62275.0 -0.342842553543639 -0.5377 -0.6186 1152846 Maybridge1_007179 Clc1cccc(Cl)c1C(=O)NC2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O08 compound treatment 677120.0 -172000.0 -0.98 734600.0 -277000.0 -1.38 899900.0 -104885.0 -0.577423383836605 -1.6997 -0.9481 1393987 Maybridge1_007180 Nc1ncnc(Nc2nc(cs2)c3ccccc3)n1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O09 compound treatment 769530.0 -79700.0 -0.46 999240.0 -11900.0 -0.06 956320.0 -48465.0 -0.266814361420995 -0.4514 -0.8499 1728517 Maybridge1_007181 COc1ccc(CCNS(=O)(=O)c2cc(C)c(Cl)cc2Cl)cc1OC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O10 compound treatment 730440.0 -119000.0 -0.68 825600.0 -186000.0 -0.93 907560.0 -97225.0 -0.535252786323249 -1.2368 -0.9751 2073213 Maybridge1_007182 COc1cc(NC(=N)NC(=N)N)cc(OC)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O11 compound treatment 779850.0 -69400.0 -0.4 951800.0 -59400.0 -0.3 942280.0 -62505.0 -0.344108772529027 -0.599 -0.9932 1498392 Maybridge1_007183 Brc1ccccc1C(=O)N2CCN(Cc3ccccc3)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O12 compound treatment 751260.0 -98000.0 -0.56 931380.0 -79800.0 -0.4 939610.0 -65175.0 -0.358807923359401 -0.7608 -0.981 1006238 Maybridge1_007184 Nc1ccc(cc1)S(=O)(=O)Nc2cc(Cl)cc(Cl)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O13 compound treatment 697240.0 -152000.0 -0.87 672850.0 -338000.0 -1.69 806440.0 -198345.0 -1.09194871589905 -2.1087 -0.9615 1092526 Maybridge1_007185 c1cn2cc(nc2s1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O14 compound treatment 764480.0 -84800.0 -0.48 855410.0 -156000.0 -0.78 877450.0 -127335.0 -0.701017367410346 -1.1341 -0.9823 2073214 Maybridge1_007186 CC(=O)N(C1=NCCC(=O)S1)c2ccc(Cl)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O15 compound treatment 689870.0 -159000.0 -0.91 749860.0 -261000.0 -1.31 820320.0 -184465.0 -1.01553515278085 -1.8666 -0.9881 2073215 Maybridge1_007187 Cc1ccc(cc1)C(=O)c2c(C)ccc3ccccc23 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O16 compound treatment 843620.0 -5630.0 -0.03 1083530.0 72400.0 0.36 941720.0 -63065.0 -0.34719174049345 -0.0101 -0.0201 2073216 Maybridge1_007188 CC(=C)Cc1c(C)nc(S)nc1O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O17 compound treatment 804480.0 -44800.0 -0.26 876860.0 -134000.0 -0.67 855870.0 -148915.0 -0.819821740039358 -1.0088 -0.9253 1716974 Maybridge1_007189 OC1CC(NC2(CCCC2)C1)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O18 compound treatment 781390.0 -67900.0 -0.39 868920.0 -142000.0 -0.71 969120.0 -35665.0 -0.196346522234185 -0.748 -0.8972 1256 Maybridge1_007190 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O19 compound treatment 891110.0 41900.0 0.24 782430.0 -229000.0 -1.14 956360.0 -48425.0 -0.266594149423536 -0.6764 -0.5642 1176932 Maybridge1_007191 CC1CC(=O)c2c(F)c(F)cc3c(=O)c(cn1c23)C(=O)O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O20 compound treatment 617290.0 -232000.0 -1.33 818080.0 -193000.0 -0.97 754130.0 -250655.0 -1.37993095557577 -2.1193 -0.9889 2073217 Maybridge1_007192 Sc1nc2ccccc2c(=O)n1CC3CC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O21 compound treatment 820480.0 -28800.0 -0.16 1159540.0 148000.0 0.74 942340.0 -62445.0 -0.343778454532839 0.1351 0.1619 1023643 Maybridge1_007193 Nc1nc(O)cc(n1)C(F)(F)F 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O22 compound treatment 702730.0 -147000.0 -0.84 888010.0 -123000.0 -0.62 973880.0 -30905.0 -0.17014129453659 -0.9371 -0.8899 2073218 Maybridge1_007194 NC(=N)NC(=N)Nc1cccc(Cl)c1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O23 mock treatment 884480.0 35200.0 0.2 1110990.0 99800.0 0.5 950250.0 -54535.0 -0.300231532035365 0.2311 0.3749 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 O24 mock treatment 806690.0 -42600.0 -0.24 1135330.0 124000.0 0.62 1172610.0 167825.0 0.923926961837997 0.7516 0.6596 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P01 compound treatment 914130.0 64900.0 0.37 969140.0 -42000.0 -0.21 826030.0 -178755.0 -0.984099890143608 -0.4756 -0.4435 1183103 Maybridge1_007195 CC(C)c1ccc(NC(=S)NCCC(=O)O)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P02 compound treatment 629060.0 -220000.0 -1.26 728590.0 -283000.0 -1.41 716930.0 -287855.0 -1.58472811321243 -2.4572 -0.9956 1080218 Maybridge1_007196 O=C(NC(=S)Nc1ccccn1)c2ccccc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P03 compound treatment 1011570.0 162000.0 0.93 916230.0 -94900.0 -0.47 1090480.0 85695.0 0.471776678055755 0.5336 0.4666 2073219 Maybridge1_007197 CC1=NNC(=O)C1Cc2ccc(F)cc2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P04 compound treatment 771330.0 -77900.0 -0.45 959200.0 -52000.0 -0.26 912640.0 -92145.0 -0.507285862645984 -0.7 -0.9678 2073220 Maybridge1_007198 NC(=S)Nc1cc(Cl)ccc1Cl 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P05 compound treatment 847040.0 -2210.0 -0.01 969030.0 -42100.0 -0.21 874750.0 -130035.0 -0.715881677238813 -0.5423 -0.7266 2073221 Maybridge1_007199 CCCCCCCc1c(O)[nH]nc1COC 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P06 compound treatment 981300.0 132000.0 0.75 837990.0 -173000.0 -0.87 958900.0 -45885.0 -0.252610687584904 -0.2104 -0.1789 1083209 Maybridge1_007200 S=C1SCN(CCc2ccccc2)CN1CCc3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P07 compound treatment 848440.0 -810.0 0.0 828990.0 -182000.0 -0.91 901450.0 -103335.0 -0.568890168935077 -0.8572 -0.798 1430187 Maybridge1_007201 COc1ccccc1NC(=S)NCCc2ccc(OC)c(OC)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P08 compound treatment 808640.0 -40600.0 -0.23 927940.0 -83200.0 -0.42 860180.0 -144605.0 -0.796093897313174 -0.8339 -0.8988 2073222 Maybridge1_007202 S=C(NCCc1ccccc1)N2CCC(CCCC3CCN(CC3)C(=S)NCCc4ccccc4)CC2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P09 compound treatment 961870.0 113000.0 0.64 797600.0 -214000.0 -1.07 921170.0 -83615.0 -0.460325654187899 -0.5111 -0.3845 2073223 Maybridge1_007203 Cc1ccc(Cl)cc1NC(=S)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P10 compound treatment 743160.0 -106000.0 -0.61 786400.0 -225000.0 -1.12 702280.0 -302505.0 -1.66538075728171 -1.9605 -0.9341 2073224 Maybridge1_007204 Oc1ccc(Br)cc1/C=N/c2ccc(F)c(F)c2 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P11 compound treatment 704160.0 -145000.0 -0.83 554480.0 -457000.0 -2.28 620890.0 -383895.0 -2.11345711911097 -3.0175 -0.937 2073225 Maybridge1_007205 Cc1cc(Cl)ccc1NC(=S)NN 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P12 compound treatment 1036200.0 187000.0 1.07 934240.0 -76900.0 -0.38 885360.0 -119425.0 -0.657470444912872 0.0148 0.0113 2073226 Maybridge1_007206 Clc1cccc(/C=C/2\N=C(OC2=O)c3ccccc3)c1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P13 compound treatment 1104570.0 255000.0 1.46 983440.0 -27700.0 -0.14 982500.0 -22285.0 -0.122685609084223 0.6911 0.4701 2073227 Maybridge1_007207 N/C(=N\O)/Cc1ccc(cc1)[N+](=O)[O-] 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P14 compound treatment 883250.0 34000.0 0.19 940040.0 -71100.0 -0.36 899160.0 -105625.0 -0.581497305789593 -0.429 -0.6052 2073228 Maybridge1_007208 COc1ccccc1/C=C/2\N=C(OC2=O)c3ccccc3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P15 compound treatment 984690.0 135000.0 0.77 848420.0 -163000.0 -0.81 1159840.0 155055.0 0.853624281649281 0.4696 0.3329 2073229 Maybridge1_007209 Cc1ccc(/C=C/2\N=C(OC2=O)c3ccccc3)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P16 compound treatment 22500.0 -827000.0 -4.72 25440.0 -986000.0 -4.93 20220.0 -984565.0 -5.42032563195011 -8.7026 -0.9983 2073230 Maybridge1_007210 FC(F)(F)c1cc(cc(c1)C(F)(F)F)N2C(=O)C=CC2=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P17 compound treatment 15680.0 -834000.0 -4.76 18510.0 -993000.0 -4.96 16580.0 -988205.0 -5.44036492371886 -8.7567 -0.9984 2073231 Maybridge1_007211 [O-][N+](=O)/C=C/c1cccc2ccccc12 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P18 compound treatment 811930.0 -37300.0 -0.21 866450.0 -145000.0 -0.72 932050.0 -72735.0 -0.40042799087911 -0.7722 -0.9039 1063067 Maybridge1_007212 COc1ccc(CNc2ccccn2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P19 compound treatment 867140.0 17900.0 0.1 881300.0 -130000.0 -0.65 935760.0 -69025.0 -0.380003328114808 -0.5354 -0.705 1003767 Maybridge1_007213 O=C1N(Cc2ccccc2)C(=O)c3ccccc13 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P20 compound treatment 922500.0 73300.0 0.42 993960.0 -17200.0 -0.09 992640.0 -12145.0 -0.0668618677284223 0.1533 0.3545 1107460 Maybridge1_007214 C=CCCN1C(=O)c2ccccc2C1=O 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P21 compound treatment 872400.0 23200.0 0.13 1022170.0 11000.0 0.05 897510.0 -107275.0 -0.590581050684767 -0.2329 -0.3832 1076485 Maybridge1_007215 S=C1SCN(CN1C2CCCCC2)C3CCCCC3 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P22 compound treatment 868090.0 18800.0 0.11 991360.0 -19800.0 -0.1 1064360.0 59575.0 0.327978243715171 0.1943 0.541 1627643 Maybridge1_007216 Clc1ccc(Oc2ccc(NC(=S)NCc3ccco3)cc2)cc1 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P23 mock treatment 1017170.0 168000.0 0.96 1053390.0 42200.0 0.21 955720.0 -49065.0 -0.270117541382877 0.5198 0.5102 1054.0020 CellTiterGlo(1054.0020) KRasSyntheticLethal 1054.0020.561 P24 mock treatment 965830.0 117000.0 0.67 988000.0 -23200.0 -0.12 1114580.0 109795.0 0.604454406524671 0.6666 0.7351