ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B RAW_VALUE_C BSUB_VALUE_C Z_SCORE_C RAW_VALUE_D BSUB_VALUE_D Z_SCORE_D COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A01 compound treatment 1076400.0 -368000.0 -1.8 1004540.0 -742000.0 -3.29 1491260.0 -28709.375 -0.149642402169727 1613970.0 -204657.09677419 -0.986776811140519 -3.1144 -0.8021 2074793 Maybridge2_000353 Cc1ccc(NC(=O)C2CN(Cc3ccco3)C(=O)C2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A02 compound treatment 1125820.0 -318000.0 -1.56 1150810.0 -596000.0 -2.64 1327720.0 -192249.375 -1.0020649453577 1398000.0 -420627.09677419 -2.02810003550522 -3.616 -0.9485 1173073 Maybridge2_000354 CN(C)CCNc1cc(nc2ccccc12)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A03 compound treatment 1318720.0 -125000.0 -0.61 1401550.0 -345000.0 -1.53 1552670.0 32700.625 0.170446067789752 1664690.0 -153937.09677419 -0.742224725481504 -1.3589 -0.7476 1014318 Maybridge2_000355 OC(=O)CN(Cc1ccccc1)Cc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A04 compound treatment 1214030.0 -230000.0 -1.13 1359680.0 -387000.0 -1.72 1496380.0 -23589.375 -0.122955332210558 1643740.0 -174887.09677419 -0.843237465910454 -1.9051 -0.8567 2074794 Maybridge2_000356 CS/C(=C(/C#N)\S(=O)(=O)c1ccc(Cl)cc1)/N2CCSCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A05 compound treatment 1401010.0 -43200.0 -0.21 1517520.0 -229000.0 -1.02 1667700.0 147730.625 0.770019047751303 1739120.0 -79507.09677419 -0.383352254353733 -0.4211 -0.3122 2074795 Maybridge2_000357 Fc1cn(C2CCCO2)c(=O)n(Cc3cccc4ccccc34)c1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A06 compound treatment 1435200.0 -9010.0 -0.04 1411810.0 -335000.0 -1.49 1638970.0 119000.625 0.620269141515579 1763680.0 -54947.09677419 -0.26493349994156 -0.5876 -0.3598 1411803 Maybridge2_000358 S=C1SC(CC(=C1)N2CCCCC2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A07 compound treatment 1373130.0 -71100.0 -0.35 1373760.0 -373000.0 -1.66 1596770.0 76800.625 0.400309307086495 1658960.0 -159667.09677419 -0.769852553770663 -1.1862 -0.624 2074796 Maybridge2_000359 Cc1cc(C)c(C#N)c(n1)N2CCN(CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A08 compound treatment 1539840.0 95600.0 0.47 1317570.0 -429000.0 -1.9 1767920.0 247950.625 1.29239759292862 1833150.0 14522.90322581 0.0700237829987359 -0.037 -0.0157 1585551 Maybridge2_000360 Cc1ccc(SC2CN(C2)C(c3ccccc3)c4ccccc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A09 compound treatment 1469410.0 25200.0 0.12 1370580.0 -376000.0 -1.67 1667270.0 147300.625 0.767777750860201 1858210.0 39582.90322581 0.190853342671743 -0.2936 -0.1586 1016614 Maybridge2_000361 CN(C)c1ccc(cc1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A10 compound treatment 1390010.0 -54200.0 -0.27 1345860.0 -401000.0 -1.78 1496700.0 -23269.375 -0.12128739033811 1525370.0 -293257.09677419 -1.41397150336033 -1.7897 -0.7812 2074797 Maybridge2_000362 Cc1nc2c(N3CCOCC3)c(Cl)c(Cl)c(Cl)c2[nH]1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A11 compound treatment 1170910.0 -273000.0 -1.34 1330480.0 -416000.0 -1.85 1378050.0 -141919.375 -0.739728962731729 1555110.0 -263517.09677419 -1.27057680644591 -2.5974 -0.9573 2074798 Maybridge2_000363 Clc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)CN5CCOCC5 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A12 compound treatment 1353070.0 -91100.0 -0.45 1708320.0 -38700.0 -0.17 1730720.0 210750.625 1.09849935025654 1731650.0 -86977.09677419 -0.419369684950595 0.0309 0.0243 1360824 Maybridge2_000364 COC(=O)C1CSC(=CC1N(C)C)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A13 compound treatment 1352880.0 -91300.0 -0.45 1478370.0 -269000.0 -1.19 1670300.0 150330.625 0.783571075464943 1758960.0 -59667.09677419 -0.287691501603834 -0.5711 -0.3753 2074799 Maybridge2_000365 C1CCN(C1)c2nnc(c3ccccc3)c(n2)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A14 compound treatment 1497200.0 53000.0 0.26 1519250.0 -228000.0 -1.01 1710810.0 190840.625 0.99472209188016 1605190.0 -213437.09677419 -1.02911055152077 -0.3925 -0.2216 2074800 Maybridge2_000366 O=C/1Nc2ccccc2\C1=N\C3CCN(Cc4ccccc4)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A15 compound treatment 1372650.0 -71600.0 -0.35 1661620.0 -85400.0 -0.38 1611290.0 91320.625 0.475992169548825 1825200.0 6572.90322581003 0.0316919793514731 -0.1105 -0.1573 2074801 Maybridge2_000367 Cc1sc(NC(=O)CN2CCN(CC2)c3ccccc3)c(C#N)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A16 compound treatment 1477390.0 33200.0 0.16 1742560.0 -4420.0 -0.02 1669760.0 149790.625 0.780756423555187 1804760.0 -13867.09677419 -0.0668617397114267 0.4283 0.5351 2074802 Maybridge2_000368 COc1c(Cl)cc(Cl)c(OC)c1C(=O)N2CC(C)OC(C)C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A17 compound treatment 1298750.0 -145000.0 -0.71 1513280.0 -234000.0 -1.04 1495360.0 -24609.375 -0.128271896928986 1627900.0 -190727.09677419 -0.91961177657368 -1.398 -0.8945 2074803 Maybridge2_000369 O=C(Cn1cnc2sc(cc2c1=O)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A18 compound treatment 1333570.0 -111000.0 -0.54 1709290.0 -37700.0 -0.17 1632960.0 112990.625 0.588943108223664 1931930.0 113302.90322581 0.546302470329129 0.2134 0.217 2074804 Maybridge2_000370 CC(=O)Cn1cc(Cl)c(=O)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A19 compound treatment 1058630.0 -386000.0 -1.89 1215290.0 -532000.0 -2.36 1255940.0 -264029.375 -1.37620515662119 1358090.0 -460537.09677419 -2.220530511425 -3.9207 -0.9819 2074805 Maybridge2_000371 CC(=O)c1sc2nsc(SCCN3CCCC3)c2c1N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A20 compound treatment 1558760.0 115000.0 0.56 1655430.0 -91500.0 -0.41 1529140.0 9170.625 0.0478002169813083 1740580.0 -78047.09677419 -0.376312702992097 -0.087 -0.1102 2074806 Maybridge2_000372 COc1cc(c(cn1)C(=O)N(C)Cc2ccccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A21 compound treatment 1218580.0 -226000.0 -1.1 1465680.0 -281000.0 -1.25 1314720.0 -205249.375 -1.0698250839259 1658240.0 -160387.09677419 -0.773324113346264 -2.0974 -0.9868 2074807 Maybridge2_000373 CCOC(=O)c1cc(sc1NC(=O)CN2CCCC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A22 compound treatment 1200850.0 -243000.0 -1.19 1502160.0 -245000.0 -1.09 1410190.0 -109779.375 -0.572205050917731 1673280.0 -145347.09677419 -0.700807091100373 -1.7748 -0.9603 2074808 Maybridge2_000374 CCSc1cc(c(cn1)C(=O)N(C)Cc2c(OC)cccc2OC)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A23 mock treatment 1401560.0 -42600.0 -0.21 1591270.0 -156000.0 -0.69 1567240.0 47270.625 0.246389546169651 1781180.0 -37447.09677419 -0.180555315812365 -0.4167 -0.5319 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 A24 mock treatment 1453880.0 9670.0 0.05 1574530.0 -172000.0 -0.76 1543230.0 23260.625 0.121241782552535 1761880.0 -56747.09677419 -0.273612398880563 -0.4349 -0.5287 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B01 compound treatment 1094880.0 -349000.0 -1.71 1283760.0 -463000.0 -2.05 1448640.0 -71329.375 -0.371791410306398 1579530.0 -239097.09677419 -1.15283307750677 -2.6441 -0.9012 2074809 Maybridge2_000375 CC(C)N(C(C)C)C1N=C(c2ccccc2)c3cc(Cl)ccc3N(C)C1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B02 compound treatment 1060270.0 -384000.0 -1.88 1054640.0 -692000.0 -3.07 1390570.0 -129399.375 -0.6744707369722 1252720.0 -565907.09677419 -2.72858361209319 -4.1761 -0.9144 2074810 Maybridge2_000376 Clc1cccc(NC(=O)OC2CN3CCC2CC3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B03 compound treatment 1436480.0 -7730.0 -0.04 1399600.0 -347000.0 -1.54 1598120.0 78150.625 0.407345936860886 1735740.0 -82887.09677419 -0.399649297916972 -0.7853 -0.4779 1238984 Maybridge2_000377 Clc1ccc(C(=O)N2CCN(Cc3ccccc3)CC2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B04 compound treatment 1320960.0 -123000.0 -0.6 1147970.0 -599000.0 -2.66 1582720.0 62750.625 0.327076234249324 1352090.0 -466537.09677419 -2.24946017455501 -2.591 -0.7303 2074811 Maybridge2_000378 OC(=O)CC1(CC(=O)Nc2ccc(cc2)N3CCCCC3)CCCCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B05 compound treatment 1370110.0 -74100.0 -0.36 1054150.0 -693000.0 -3.07 1413570.0 -106399.375 -0.554587414889999 1480390.0 -338237.09677419 -1.63084754462497 -2.8103 -0.7936 2074812 Maybridge2_000379 CCCc1c(C)nc(SCc2c(F)cccc2Cl)nc1OC(=O)N(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B06 compound treatment 1512560.0 68400.0 0.33 1371200.0 -376000.0 -1.67 1641090.0 121120.625 0.631319256420547 1594130.0 -224497.09677419 -1.08243756389042 -0.8916 -0.4222 2074813 Maybridge2_000380 Fc1ccc(cc1)S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B07 compound treatment 1510560.0 66400.0 0.32 1191790.0 -555000.0 -2.46 1723210.0 203240.625 1.05935483943752 1776680.0 -41947.09677419 -0.202252563159872 -0.6402 -0.2364 2074814 Maybridge2_000381 Clc1ccc(Cn2nnc(n2)N3CCCC3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B08 compound treatment 1416510.0 -27700.0 -0.14 1487040.0 -260000.0 -1.15 1648730.0 128760.625 0.671141368625243 1633600.0 -185027.09677419 -0.892128596600171 -0.7546 -0.4686 2074815 Maybridge2_000382 O=C(N1CCC(=CC1)c2ccccc2)c3csc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B09 compound treatment 1301460.0 -143000.0 -0.7 1284920.0 -462000.0 -2.05 1622420.0 102450.625 0.534005272799907 1695720.0 -122907.09677419 -0.592610150994137 -1.4031 -0.6082 2074816 Maybridge2_000383 CN(C)C(=O)Oc1nc(nc(C)c1C)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B10 compound treatment 1444880.0 672.0 0.0 1258420.0 -489000.0 -2.17 1714100.0 194130.625 1.01187061925627 1743880.0 -74747.09677419 -0.360401388270592 -0.7559 -0.3126 2074817 Maybridge2_000384 O=S(=O)(N1CCC(=CC1)c2ccccc2)c3ccsc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B11 compound treatment 1333660.0 -111000.0 -0.54 1338940.0 -408000.0 -1.81 1775250.0 255280.625 1.33060388644438 1894740.0 76112.90322581 0.366986775028286 -0.3265 -0.1396 2074818 Maybridge2_000385 CC(=O)N1C(CSC1c2cccs2)C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B12 compound treatment 1525180.0 81000.0 0.4 1251080.0 -496000.0 -2.2 1747490.0 227520.625 1.18590992900952 1651520.0 -167107.09677419 -0.805725336051875 -0.7114 -0.2679 2074819 Maybridge2_000386 Cc1ccc(C)n1CCN2CCN(CC2)S(=O)(=O)Cc3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B13 compound treatment 785920.0 -658000.0 -3.22 451430.0 -1300000.0 -5.75 430570.0 -1089399.375 -5.67829635431627 609920.0 -1208707.09677419 -5.82791485542156 -10.2365 -0.9778 2071084 Maybridge2_000387 CN1C/C(=C\c2ccccc2)/C(=O)\C(=C\c3ccccc3)\C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B14 compound treatment 1453450.0 9240.0 0.05 1568430.0 -179000.0 -0.79 1485350.0 -34619.375 -0.180447203626501 1617600.0 -201027.09677419 -0.969274364946863 -0.9482 -0.7493 2074820 Maybridge2_000388 CN1CCN(CC1)c2ccc(NC(=O)c3cccc4CC(C)(C)Oc43)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B15 compound treatment 1319800.0 -124000.0 -0.61 1573370.0 -174000.0 -0.77 1447410.0 -72559.375 -0.37820256187862 1792550.0 -26077.09677419 -0.125733604180996 -0.9413 -0.8886 2074821 Maybridge2_000389 CC1C(N2CCCCC2)C(=O)N(C1=O)c3ccc(C)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B16 compound treatment 1282620.0 -162000.0 -0.79 1636200.0 -111000.0 -0.49 1504720.0 -15249.375 -0.0794845971598815 1803870.0 -14757.09677419 -0.0711529730757115 -0.7163 -0.7645 2074822 Maybridge2_000390 Fc1cc(CN2CCS(=O)(=O)CC2)c3OCOCc3c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B17 compound treatment 1296000.0 -148000.0 -0.73 1526750.0 -220000.0 -0.98 1490820.0 -29149.375 -0.151935822244343 1867600.0 48972.90322581 0.236128265470208 -0.8088 -0.6479 2074823 Maybridge2_000391 CN(C)c1ccncc1C(O)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B18 compound treatment 1238570.0 -206000.0 -1.01 1674010.0 -73000.0 -0.32 1474780.0 -45189.375 -0.2355414086008 1868640.0 50012.90322581 0.241142740412743 -0.6621 -0.5968 2074824 Maybridge2_000392 O=S1(=O)CCN(Cc2ccc(cc2)N3CCOCC3)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B19 compound treatment 1270830.0 -173000.0 -0.85 1634140.0 -113000.0 -0.5 1375470.0 -144499.375 -0.753176744078341 1861940.0 43312.90322581 0.208837949917566 -0.9466 -0.7528 2074825 Maybridge2_000393 Fc1ccc(cc1)C2CCCN2S(=O)(=O)c3cccc4cccnc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B20 compound treatment 1257760.0 -186000.0 -0.91 1594000.0 -153000.0 -0.68 1601700.0 81730.625 0.426006036558898 1987760.0 169132.90322581 0.81549298575387 -0.1746 -0.1194 2074826 Maybridge2_000394 FC(F)(F)c1ccc(cc1)S(=O)(=O)NCCN2CCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B21 compound treatment 1437520.0 -6690.0 -0.03 1594280.0 -153000.0 -0.68 1493510.0 -26459.375 -0.137914685879076 1847520.0 28892.90322581 0.139310326195109 -0.3543 -0.502 2074827 Maybridge2_000395 FC(F)(F)c1cccc(c1)S(=O)(=O)N2CCCC2c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B22 compound treatment 1287900.0 -156000.0 -0.76 1860020.0 113000.0 0.5 1518780.0 -1189.375 -0.00619940113919647 1895420.0 76792.90322581 0.37026547018302 0.0503 0.0509 2074828 Maybridge2_000396 OC(CN1CCC(=CC1)c2ccccc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B23 mock treatment 1321170.0 -123000.0 -0.6 1810830.0 63900.0 0.28 1543560.0 23590.625 0.122961847608497 1834940.0 16312.90322581 0.0786544658325222 -0.0586 -0.0861 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 B24 mock treatment 1427710.0 -16500.0 -0.08 1716710.0 -30300.0 -0.13 1511450.0 -8519.375 -0.044405694654959 1457520.0 -361107.09677419 -1.74111777725552 -1.0002 -0.572 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C01 compound treatment 1200690.0 -244000.0 -1.19 1439210.0 -308000.0 -1.36 1685450.0 165480.625 0.862537698488654 1628870.0 -189757.09677419 -0.914934814367662 -1.3044 -0.5915 2074829 Maybridge2_000397 Fc1ccc(NC(=O)C2CN(Cc3ccco3)C(=O)C2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C02 compound treatment 1389700.0 -54500.0 -0.27 1353090.0 -394000.0 -1.75 1488340.0 -31629.375 -0.164862371755815 1582200.0 -236427.09677419 -1.13995937741392 -1.6592 -0.7866 1122383 Maybridge2_000398 CN1CCN(CC1)c2cc(nc3ccccc23)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C03 compound treatment 1413460.0 -30700.0 -0.15 1154620.0 -592000.0 -2.63 1685160.0 165190.625 0.861026126166748 1489820.0 -328807.09677419 -1.58537975740564 -1.7509 -0.5488 2074830 Maybridge2_000399 Cc1ccccc1Cn2cc(C)c(=O)[nH]c2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C04 compound treatment 1542560.0 98400.0 0.48 1065620.0 -681000.0 -3.02 1669280.0 149310.625 0.778254510746515 1604450.0 -214177.09677419 -1.0326785433068 -1.3974 -0.4207 2074831 Maybridge2_000400 Clc1ccc(CS(=O)(=O)/C(=C/N2CCOCC2)/C#N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C05 compound treatment 1614270.0 170000.0 0.83 1410310.0 -337000.0 -1.49 1877810.0 357840.625 1.86517925656397 1975600.0 156972.90322581 0.756862201810383 0.9806 0.3713 1009314 Maybridge2_000401 CCN(CC)c1ncnc2[nH]cnc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C06 compound treatment 1491160.0 47000.0 0.23 1178620.0 -568000.0 -2.52 1713040.0 193070.625 1.00634556180378 1644110.0 -174517.09677419 -0.841453470017437 -1.0629 -0.3729 2074832 Maybridge2_000402 COc1ccc(cc1)C(=O)/C(=C/N2CCc3ccccc3C2)/C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C07 compound treatment 1389320.0 -54900.0 -0.27 1164160.0 -583000.0 -2.58 1571320.0 51350.625 0.267655805043364 1719900.0 -98727.09677419 -0.476023608580197 -1.5308 -0.5765 2074833 Maybridge2_000403 Cc1cc(C)c2c(n1)sc3c(=O)n(CC=C)cnc32 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C08 compound treatment 1437570.0 -6640.0 -0.03 1300340.0 -447000.0 -1.98 1765120.0 245150.625 1.2778031015447 1805630.0 -12997.09677419 -0.0626669385575753 -0.399 -0.1692 1199989 Maybridge2_000404 C1C(CN1C(c2ccccc2)c3ccccc3)Sc4nc5ccccc5s4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C09 compound treatment 1465620.0 21400.0 0.1 1311010.0 -436000.0 -1.93 1778240.0 258270.625 1.34618871831507 1696160.0 -122467.09677419 -0.590488642364603 -0.5365 -0.2207 2074834 Maybridge2_000405 O=C(Nc1csc2ccccc12)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C10 compound treatment 1492760.0 48600.0 0.24 1548610.0 -198000.0 -0.88 1655710.0 135740.625 0.707523350718016 1763870.0 -54757.09677419 -0.264017393942443 -0.0993 -0.0839 2074835 Maybridge2_000406 CCN(CC)CC(=O)c1sc2ccc(Cl)cc2c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C11 compound treatment 1256180.0 -188000.0 -0.92 1467690.0 -279000.0 -1.24 1664650.0 144680.625 0.754121476779533 1780710.0 -37917.09677419 -0.182821472757549 -0.7937 -0.4596 2074836 Maybridge2_000407 O=C(CN1CCc2ccccc12)N3CCc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C12 compound treatment 1448280.0 4070.0 0.02 1296740.0 -450000.0 -2.0 1651730.0 131760.625 0.686778323679444 1767040.0 -51587.09677419 -0.248732888588754 -0.7694 -0.3618 2074837 Maybridge2_000408 Brc1ccc(cc1)n2nnnc2/C=C/N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C13 compound treatment 1551130.0 107000.0 0.52 1809390.0 62400.0 0.28 1777550.0 257580.625 1.3425922186526 1976130.0 157502.90322581 0.759417655386867 1.451 0.8782 2074838 Maybridge2_000409 O=C(CN1CCCc2ccccc12)N3CCCc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C14 compound treatment 1331840.0 -112000.0 -0.55 1275130.0 -472000.0 -2.09 1717280.0 197310.625 1.02844579161372 1924170.0 105542.90322581 0.508886772680983 -0.5525 -0.2256 1480993 Maybridge2_000410 O=C(N1CCN(Cc2ccccc2)CC1)c3cc4CCc5ccccc5-c4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C15 compound treatment 1190200.0 -254000.0 -1.24 1311540.0 -435000.0 -1.93 1564930.0 44960.625 0.234349090777917 1788590.0 -30037.09677419 -0.144827181846803 -1.5422 -0.6668 2074839 Maybridge2_000411 Cc1sc(NC(=O)CN2CCc3ccccc23)c(C#N)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C16 compound treatment 1203550.0 -241000.0 -1.18 1758300.0 11300.0 0.05 1462400.0 -57569.375 -0.300069909791133 1813600.0 -5027.09677418997 -0.024238702699879 -0.7259 -0.5967 2074840 Maybridge2_000412 Oc1cc(CN2CCCC2)nc(n1)c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C17 compound treatment 1532240.0 88000.0 0.43 1559430.0 -188000.0 -0.83 1434620.0 -85349.375 -0.444868113593027 1857670.0 39042.90322581 0.188249672990042 -0.3288 -0.312 2074841 Maybridge2_000413 CC(=O)Cn1cnc2sc(cc2c1=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C18 compound treatment 1387710.0 -56500.0 -0.28 1651720.0 -95300.0 -0.42 1626370.0 106400.625 0.554593930287938 1817520.0 -1107.09677418997 -0.00533798945493936 -0.0748 -0.0998 2074842 Maybridge2_000414 Clc1ccc(cc1)C(=O)N(Cc2cccnc2)Cc3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C19 compound treatment 1332900.0 -111000.0 -0.54 1842940.0 96000.0 0.43 1526240.0 6270.625 0.0326844937622481 1862950.0 44322.90322581 0.213707776544451 0.0636 0.0879 2074843 Maybridge2_000415 CC(=O)c1sc2nsc(SCCN3CCOCC3)c2c1N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C20 compound treatment 1428840.0 -15400.0 -0.08 1565840.0 -181000.0 -0.8 1508450.0 -11519.375 -0.0600426497091593 1929470.0 110842.90322581 0.534441308445825 -0.202 -0.2084 2074844 Maybridge2_000416 COc1cc(c(cn1)C(=O)N(C)Cc2cccc(Cl)c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C21 compound treatment 1238120.0 -206000.0 -1.01 1908800.0 162000.0 0.72 1314570.0 -205399.375 -1.07060693167861 1902730.0 84102.90322581 0.405511443096415 -0.478 -0.2835 2074845 Maybridge2_000417 Fc1ccc(cc1)N2CCN(CC2)C3=Cc4ccccc4CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C22 compound treatment 1221890.0 -222000.0 -1.09 1645380.0 -102000.0 -0.45 1559700.0 39730.625 0.207088665800095 1885960.0 67332.90322581 0.324653034648038 -0.5034 -0.4063 2074846 Maybridge2_000418 COc1cccc(OC)c1CN(C)C(=O)c2cnccc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C23 mock treatment 1234660.0 -210000.0 -1.03 1859910.0 113000.0 0.5 1365920.0 -154049.375 -0.802954384334212 1906400.0 87772.90322581 0.423206753710938 -0.4522 -0.3101 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 C24 mock treatment 1190980.0 -253000.0 -1.24 1697950.0 -49000.0 -0.22 1399840.0 -120129.375 -0.626152545854722 1800650.0 -17977.09677419 -0.0866785589554833 -1.0847 -0.7704 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D01 compound treatment 1199040.0 -245000.0 -1.2 981280.0 -766000.0 -3.4 1498670.0 -21299.375 -0.111019123185852 1640020.0 -178607.09677419 -0.86117385705106 -2.7838 -0.7514 1687697 Maybridge2_000419 Clc1ccccc1CN2CCN(CC2)c3cccc4[nH]ccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D02 compound treatment 1416320.0 -27900.0 -0.14 1168670.0 -578000.0 -2.56 1300320.0 -219649.375 -1.14488246818606 1408680.0 -409947.09677419 -1.9766052351338 -2.9113 -0.847 2074847 Maybridge2_000420 Clc1ccc(NC(=O)OC2CN3CCC2CC3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D03 compound treatment 1534470.0 90300.0 0.44 1507840.0 -239000.0 -1.06 1446320.0 -73649.375 -0.383883988881646 1782730.0 -35897.09677419 -0.173081819503779 -0.5879 -0.4805 1224648 Maybridge2_000421 O=C(N1CCN(Cc2ccccc2)CC1)c3ccco3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D04 compound treatment 1533140.0 88900.0 0.44 1177690.0 -569000.0 -2.52 1675610.0 155640.625 0.811248485910878 1472870.0 -345757.09677419 -1.66710605574791 -1.4727 -0.4657 2074848 Maybridge2_000422 Cc1noc(c1NC(=O)N2CCSCC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D05 compound treatment 1517460.0 73300.0 0.36 1355520.0 -391000.0 -1.74 1678040.0 158070.625 0.82391441950478 1530690.0 -287937.09677419 -1.38832053538505 -0.971 -0.405 2074849 Maybridge2_000423 Cc1nc(nc(O)c1Cc2c(F)cccc2Cl)N3CCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D06 compound treatment 1543370.0 99200.0 0.49 1792270.0 45300.0 0.2 1707560.0 187590.625 0.97778205723811 1446180.0 -372447.09677419 -1.79579484057124 -0.066 -0.0312 2074850 Maybridge2_000424 Cc1ccc(cc1F)S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D07 compound treatment 1286090.0 -158000.0 -0.77 1188480.0 -558000.0 -2.48 1496370.0 -23599.375 -0.123007455394072 1686240.0 -132387.09677419 -0.638319018739552 -2.0059 -0.7499 2074851 Maybridge2_000425 CN(C)C(=O)Oc1cc(C)nc(n1)c2ccc(F)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D08 compound treatment 1595730.0 152000.0 0.74 1257920.0 -489000.0 -2.17 1792640.0 272670.625 1.42124610257523 1797700.0 -20927.09677419 -0.100902309994405 -0.0535 -0.0198 2074852 Maybridge2_000426 O=C(N1CCC(=CC1)c2ccccc2)c3csc(n3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D09 compound treatment 1295620.0 -149000.0 -0.73 1433920.0 -313000.0 -1.39 1588020.0 68050.625 0.354701521511745 1670720.0 -147907.09677419 -0.713150414035844 -1.2369 -0.7036 2074853 Maybridge2_000427 CCc1cc(OC(=O)N(C)C)nc(n1)c2ccc(F)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D10 compound treatment 1433790.0 -10400.0 -0.05 1250620.0 -496000.0 -2.2 1718040.0 198070.625 1.03240715356078 1619550.0 -199077.09677419 -0.95987222442961 -1.0898 -0.4169 2074854 Maybridge2_000428 O=S(=O)(N1CCC(=CC1)c2ccccc2)c3ccc4OCCCOc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D11 compound treatment 1494610.0 50400.0 0.25 1817500.0 70500.0 0.31 1797330.0 277360.625 1.44569187564329 1829960.0 11332.90322581 0.0546428454346141 1.0299 0.6863 2074855 Maybridge2_000429 CCN(CC)C(=O)Sc1c(Br)cc(Br)cc1Br 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D12 compound treatment 1483040.0 38800.0 0.19 1474930.0 -272000.0 -1.21 1790830.0 270860.625 1.41181180635919 1888900.0 70272.90322581 0.338828569581743 0.3671 0.1935 2074856 Maybridge2_000430 NC(=O)C1CCN(CC1)S(=O)(=O)Cc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D13 compound treatment 1664570.0 220000.0 1.08 1471770.0 -275000.0 -1.22 1654760.0 134790.625 0.702571648284186 1651770.0 -166857.09677419 -0.804519933421458 -0.122 -0.0627 2074637 Maybridge2_000431 CN1C/C(=C\c2cccs2)/C(=O)\C(=C\c3cccs3)\C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D14 compound treatment 1464530.0 20300.0 0.1 1365050.0 -382000.0 -1.69 1699320.0 179350.625 0.934832554022573 1829950.0 11322.90322581 0.0545946293293974 -0.3024 -0.1561 2074857 Maybridge2_000432 CC1(C)Cc2cccc(C(=O)N3CCC(CC3)C(=O)c4ccc(Cl)cc4)c2O1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D15 compound treatment 1389280.0 -54900.0 -0.27 1688600.0 -58400.0 -0.26 1781220.0 261250.625 1.36172142700224 1943080.0 124452.90322581 0.600063427645731 0.7171 0.4674 2074858 Maybridge2_000433 CN1N=C/2C(CN(C)C\C2=C/c3ccc(cc3)C(F)(F)F)C1c4ccc(cc4)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D16 compound treatment 1349530.0 -94700.0 -0.46 1438650.0 -308000.0 -1.37 1797380.0 277410.625 1.44595249156086 1910930.0 92302.90322581 0.445048649374095 0.0302 0.0144 2074859 Maybridge2_000434 O=S1(=O)CCN(Cc2ccc(cc2)n3cccn3)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D17 compound treatment 1292800.0 -151000.0 -0.74 1800670.0 53700.0 0.24 1391420.0 -128549.375 -0.67004026637351 1892410.0 73782.90322581 0.355752422512799 -0.4085 -0.3759 2074860 Maybridge2_000435 CC(=O)N1CCC(CC1)C(=O)Nc2nc3ccc(Cl)cc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D18 compound treatment 1140480.0 -304000.0 -1.49 1657190.0 -89800.0 -0.4 1322150.0 -197819.375 -1.03109755857499 1838400.0 19772.90322581 0.0953372382374945 -1.4101 -0.7603 2074861 Maybridge2_000436 O=S(=O)(N(Cc1ccccn1)Cc2ccccn2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D19 compound treatment 1751640.0 307000.0 1.5 1843970.0 97000.0 0.43 1720680.0 200710.625 1.04616767400848 1828160.0 9532.90322581003 0.0459639464956112 1.5133 0.8038 2074862 Maybridge2_000437 CN1CCOc2cc(ccc12)S(=O)(=O)N3CCCC3c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D20 compound treatment 1359200.0 -85000.0 -0.42 1825400.0 78400.0 0.35 1314620.0 -205349.375 -1.07034631576104 1852130.0 33502.90322581 0.1615379507 -0.4885 -0.4035 2074863 Maybridge2_000438 Cc1cc(nn1C)C(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D21 compound treatment 1205090.0 -239000.0 -1.17 1776200.0 29200.0 0.13 1250330.0 -269639.375 -1.40544626257255 1896800.0 78172.90322581 0.376919292702922 -1.0345 -0.5527 2074864 Maybridge2_000439 Cc1ccc(cc1)S(=O)(=O)N2CCCC2c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D22 compound treatment 1305300.0 -139000.0 -0.68 1712170.0 -34800.0 -0.15 1380330.0 -139639.375 -0.727844876890537 1898130.0 79502.90322581 0.383332034696741 -0.5893 -0.5465 2074865 Maybridge2_000440 OC(CNCc1cc2ccccc2s1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D23 mock treatment 1618170.0 174000.0 0.85 1749030.0 2050.0 0.01 1523860.0 3890.625 0.0202791760859159 1842910.0 24282.90322581 0.117082701690218 0.4989 0.5804 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 D24 mock treatment 1447770.0 3560.0 0.02 1816800.0 69800.0 0.31 1543270.0 23300.625 0.121450275286591 1947860.0 129232.90322581 0.623110725939305 0.5358 0.7584 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E01 compound treatment 1328640.0 -116000.0 -0.57 1418460.0 -329000.0 -1.46 1625290.0 105320.625 0.548964626468426 1639920.0 -178707.09677419 -0.861656018103227 -1.1675 -0.6253 2074866 Maybridge2_000441 FC(F)(F)c1ccc(nc1)N2CCCN(CC2)C(=O)Nc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E02 compound treatment 817170.0 -627000.0 -3.07 524400.0 -1220000.0 -5.42 776500.0 -743469.375 -3.87519906701645 881780.0 -936847.09677419 -4.51711181900082 -8.4412 -0.9797 2074867 Maybridge2_000442 CN(C)C(=O)Oc1ccnc(SCc2c(Cl)cccc2Cl)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E03 compound treatment 1254360.0 -190000.0 -0.93 1094150.0 -653000.0 -2.9 1408520.0 -111449.375 -0.580909622564569 1373240.0 -445387.09677419 -2.14748311202173 -3.2763 -0.8696 1286698 Maybridge2_000443 CN(C)c1ccc(NC(=O)c2ccc(Cl)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E04 compound treatment 1437760.0 -6450.0 -0.03 1054930.0 -692000.0 -3.07 1432880.0 -87089.375 -0.453937547524463 1314470.0 -504157.09677419 -2.43084916238017 -2.9927 -0.7593 2074868 Maybridge2_000444 Cc1nc(ncc1S(=O)(=O)c2ccc(Cl)cc2)N3CCSCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E05 compound treatment 1482720.0 38500.0 0.19 1105320.0 -642000.0 -2.85 1729540.0 209570.625 1.09234881460188 1479680.0 -338947.09677419 -1.63427088809535 -1.5995 -0.4618 1538786 Maybridge2_000445 Clc1ccc(CNCc2cccnc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E06 compound treatment 1662240.0 218000.0 1.07 1176560.0 -570000.0 -2.53 1702210.0 182240.625 0.94989615405812 1593670.0 -224957.09677419 -1.08465550473039 -0.7987 -0.2576 2074869 Maybridge2_000446 CN(C)CC#Cc1ccc(s1)c2ccn(n2)S(=O)(=O)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E07 compound treatment 1275420.0 -169000.0 -0.83 1570880.0 -176000.0 -0.78 1407070.0 -112899.375 -0.588467484174099 1573070.0 -245557.09677419 -1.18398068147675 -1.6897 -0.9691 2074870 Maybridge2_000447 Cc1cc(C)c2c(n1)sc3c(ncnc32)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E08 compound treatment 1370780.0 -73400.0 -0.36 1305570.0 -441000.0 -1.96 1710790.0 190820.625 0.994617845513132 1535520.0 -283107.09677419 -1.3650321565654 -1.3436 -0.5147 2074871 Maybridge2_000448 OC(=O)CCCN1CCC(=CC1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E09 compound treatment 1464700.0 20500.0 0.1 1349380.0 -398000.0 -1.76 1821190.0 301220.625 1.5700577915077 1683630.0 -134997.09677419 -0.650903422201106 -0.3719 -0.1517 2074872 Maybridge2_000449 NC(=O)C1CCN(CC1)C(=O)Nc2csc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E10 compound treatment 1355740.0 -88500.0 -0.43 1203280.0 -544000.0 -2.41 1637520.0 117550.625 0.612711279906049 1478240.0 -340387.09677419 -1.64121400724656 -1.9363 -0.6429 2074873 Maybridge2_000450 CN(C)/C=C(\C#N)/C(=O)c1sc2ccc(Cl)cc2c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E11 compound treatment 1153180.0 -291000.0 -1.42 1261940.0 -485000.0 -2.15 1502520.0 -17449.375 -0.0909516975329617 1667680.0 -150947.09677419 -0.727808110021715 -2.1969 -0.8192 2074874 Maybridge2_000451 O=C(CN1CCCc2ccccc12)N3CCc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E12 compound treatment 1432010.0 -12200.0 -0.06 1904480.0 158000.0 0.7 1730110.0 210140.625 1.09531983606218 1769990.0 -48637.09677419 -0.234509137549833 0.7498 0.5674 2074875 Maybridge2_000452 Brc1ccc(cc1)n2nnnc2/C=C/N3CCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E13 compound treatment 1724230.0 280000.0 1.37 1627200.0 -120000.0 -0.53 1954020.0 434050.625 2.26241003812417 1944320.0 125692.90322581 0.606042224692599 1.8538 0.6704 2074876 Maybridge2_000453 O=C(CN1CCc2ccccc12)N3CCCc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E14 compound treatment 1262620.0 -182000.0 -0.89 1777520.0 30500.0 0.14 1520120.0 150.625 7.85105451679637E-4 1857170.0 38542.90322581 0.185838867729208 -0.2833 -0.3086 2074877 Maybridge2_000454 CN(CCC#N)c1ccc(/C=C\2/N=C(OC2=O)c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E15 compound treatment 1325880.0 -118000.0 -0.58 1533610.0 -213000.0 -0.95 1517960.0 -2009.375 -0.0104735021873445 1821450.0 2822.90322581003 0.013610939895217 -0.7611 -0.686 2074878 Maybridge2_000455 Cc1sc(NC(=O)CN2CCCC2)c(C#N)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E16 compound treatment 1175680.0 -269000.0 -1.31 1437440.0 -310000.0 -1.37 1331240.0 -188729.375 -0.983717584760767 1792220.0 -26407.09677419 -0.127324735653147 -1.8989 -0.8859 2074879 Maybridge2_000456 CC1CN(CC(C)O1)c2nc(cc(c2C#N)C(F)(F)F)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E17 compound treatment 1381120.0 -63100.0 -0.31 1665980.0 -81000.0 -0.36 1502120.0 -17849.375 -0.0930366248735217 1899100.0 80472.90322581 0.388008996902759 -0.1865 -0.3011 1247492 Maybridge2_000457 Clc1ccccc1Cn2cnc3sc(cc3c2=O)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E18 compound treatment 1151050.0 -293000.0 -1.43 1285000.0 -462000.0 -2.05 1614440.0 94470.625 0.492410972355735 1926180.0 107552.90322581 0.518578209829537 -1.2362 -0.4752 2074880 Maybridge2_000458 CC(C)(C)C(=O)N(Cc1ccc(Cl)cc1)Cc2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E19 compound treatment 1332390.0 -112000.0 -0.55 1891000.0 144000.0 0.64 1838130.0 318160.625 1.65835446438042 1857220.0 38592.90322581 0.186079948255292 0.968 0.518 2074881 Maybridge2_000459 Nc1c(sc2nsc(SCCN3CCCCC3)c12)C(=O)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E20 compound treatment 1110260.0 -334000.0 -1.63 1844550.0 97600.0 0.43 1701450.0 181480.625 0.945934792111055 1911400.0 92772.90322581 0.447314806319279 0.0959 0.0482 2074882 Maybridge2_000460 CCN(Cc1cccc(Cl)c1)C(=O)c2cnc(OC)cc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E21 compound treatment 1198640.0 -246000.0 -1.2 1817080.0 70100.0 0.31 1507910.0 -12059.375 -0.0628573016189153 1905370.0 86742.90322581 0.41824049487362 -0.2677 -0.2041 2074883 Maybridge2_000461 C(C1CCN(CC1)C2=Cc3ccccc3CC2)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E22 compound treatment 1169810.0 -274000.0 -1.34 1855010.0 108000.0 0.48 1712720.0 192750.625 1.00467761993133 1879100.0 60472.90322581 0.291576786469394 0.2163 0.1223 1203973 Maybridge2_000462 CN(C)c1ccncc1C(=O)Nc2ccc(F)cc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E23 mock treatment 1263610.0 -181000.0 -0.88 1730090.0 -16900.0 -0.07 1477120.0 -42849.375 -0.223344583658524 1857860.0 39232.90322581 0.189165778989159 -0.4964 -0.5315 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 E24 mock treatment 1692550.0 248000.0 1.22 1783290.0 36300.0 0.16 1679750.0 159780.625 0.832827483885674 1749990.0 -68637.09677419 -0.330941347983199 0.9391 0.6184 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F01 compound treatment 1279840.0 -164000.0 -0.8 931430.0 -816000.0 -3.62 1518930.0 -1039.375 -0.00541755338648645 1560530.0 -258097.09677419 -1.24444367741847 -2.8355 -0.7255 1379513 Maybridge2_000463 Clc1ccc(CN2CCN(CC2)c3cccc4[nH]ccc34)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F02 compound treatment 1484050.0 39800.0 0.19 1115810.0 -631000.0 -2.8 1699490.0 179520.625 0.935718648142311 1535700.0 -282927.09677419 -1.3641642666715 -1.5163 -0.4655 2074884 Maybridge2_000464 Cc1ccccc1NC(=O)OC2CN3CCC2CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F03 compound treatment 1460210.0 16000.0 0.08 1046410.0 -701000.0 -3.11 1564980.0 45010.625 0.234609706695487 1367560.0 -451067.09677419 -2.1748698597848 -2.4844 -0.6537 1240135 Maybridge2_000465 CN1CCN(CC1)c2c3C4CCC(C)(c3nc5ccccc25)C4(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F04 compound treatment 1402180.0 -42000.0 -0.21 1271740.0 -475000.0 -2.11 1627950.0 107980.625 0.56282939328315 1460520.0 -358107.09677419 -1.72665294569052 -1.7385 -0.6232 2074885 Maybridge2_000466 FC(F)(F)c1cccc(CS(=O)(=O)N2CCOCC2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F05 compound treatment 1155250.0 -289000.0 -1.41 980120.0 -767000.0 -3.4 1190290.0 -329679.375 -1.71839385639061 1000090.0 -818537.09677419 -3.94666707818225 -5.2399 -0.9249 2074886 Maybridge2_000467 CN(C)C(=O)Oc1cc(C)nc(SCc2c(Cl)cccc2Cl)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F06 compound treatment 1709240.0 265000.0 1.3 1312430.0 -435000.0 -1.93 1793460.0 273490.625 1.42552020362338 1488160.0 -330467.09677419 -1.59338363087161 -0.399 -0.1264 2074887 Maybridge2_000468 Fc1cccc(c1)C(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F07 compound treatment 1642080.0 198000.0 0.97 1151360.0 -596000.0 -2.64 1697020.0 177050.625 0.922844221814353 1835770.0 17142.90322581 0.0826564025655069 -0.3338 -0.1127 2074888 Maybridge2_000469 CCN(CC)C(=O)Oc1cc(C)nc(n1)c2ccc(F)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F08 compound treatment 1475210.0 31000.0 0.15 1288090.0 -459000.0 -2.04 1673440.0 153470.625 0.799937755088339 1577050.0 -241577.09677419 -1.16479067160051 -1.1241 -0.4529 2074889 Maybridge2_000470 Cc1c(Cl)cc(F)cc1S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F09 compound treatment 1757390.0 313000.0 1.53 1224880.0 -522000.0 -2.32 1780060.0 260090.625 1.35567513771462 1520010.0 -298617.09677419 -1.43981533575647 -0.4335 -0.1272 2074890 Maybridge2_000471 CCCc1cc(=O)oc2cc(OC(=O)N(C)C)ccc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F10 compound treatment 1340840.0 -103000.0 -0.51 1596480.0 -150000.0 -0.67 1634130.0 114160.625 0.595041520694802 1598590.0 -220037.09677419 -1.06093318096378 -0.8196 -0.555 1620449 Maybridge2_000472 Fc1ccccc1S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F11 compound treatment 1265310.0 -179000.0 -0.88 1593050.0 -154000.0 -0.68 1658010.0 138040.625 0.719511682926236 1894150.0 75522.90322581 0.364142024820501 -0.2372 -0.1729 2074891 Maybridge2_000473 CCCN(CCC)S(=O)(=O)c1ccc(cc1)c2nc3ccc(C)cc3o2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F12 compound treatment 1437250.0 -6960.0 -0.03 1481400.0 -266000.0 -1.18 1703650.0 183680.625 0.957401892484136 1926560.0 107932.90322581 0.520410421827771 0.133 0.0829 2074892 Maybridge2_000474 O=S(=O)(N1CCCCC1c2cccnc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F13 compound treatment 1731550.0 287000.0 1.41 1512920.0 -234000.0 -1.04 1638910.0 118940.625 0.619956402414495 1726240.0 -92387.09677419 -0.44545459787282 0.2713 0.1423 2074893 Maybridge2_000475 O=S(=O)(N1CCOCC1)c2csc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F14 compound treatment 1407360.0 -36800.0 -0.18 1790940.0 44000.0 0.19 1556810.0 36840.625 0.192025065764548 1873790.0 55162.90322581 0.265974034599335 0.2363 0.5599 2074894 Maybridge2_000476 CN1CCN(CC1)C(=O)c2cccc3CC(C)(C)Oc32 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F15 compound treatment 1294730.0 -149000.0 -0.73 1592070.0 -155000.0 -0.69 1647210.0 127240.625 0.663218644731115 1783560.0 -35067.09677419 -0.169079882770794 -0.4621 -0.3805 2074895 Maybridge2_000477 Cc1csc2c(=O)n(CCN3CCSCC3)c(=O)[nH]c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F16 compound treatment 1254110.0 -190000.0 -0.93 1847460.0 100000.0 0.45 1515650.0 -4319.375 -0.0225139575790787 1917280.0 98652.90322581 0.475665876186689 -0.0157 -0.0138 2074896 Maybridge2_000478 Cn1cccc1CN2CCS(=O)(=O)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F17 compound treatment 1375060.0 -69100.0 -0.34 1810720.0 63700.0 0.28 1507750.0 -12219.375 -0.0636912725551393 1868840.0 50212.90322581 0.242107062517077 0.0614 0.121 2074897 Maybridge2_000479 CC(=O)N1CCC(CC1)C(=O)Nc2ccc3nc(C)ccc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F18 compound treatment 1510800.0 66600.0 0.33 1708770.0 -38200.0 -0.17 1367360.0 -152609.375 -0.795448645908196 1788730.0 -29897.09677419 -0.144152156373769 -0.3916 -0.441 1398018 Maybridge2_000480 Clc1ccc(cc1)S(=O)(=O)N(Cc2ccccn2)Cc3ccccn3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F19 compound treatment 1257170.0 -187000.0 -0.92 1705230.0 -41700.0 -0.19 1490080.0 -29889.375 -0.155792937824379 1859730.0 41102.90322581 0.198182190664679 -0.529 -0.5469 2074898 Maybridge2_000481 Fc1ccc(cc1)C2CCCN2S(=O)(=O)c3ccc(cc3)c4cnco4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F20 compound treatment 1302720.0 -141000.0 -0.69 1711050.0 -35900.0 -0.16 1308230.0 -211739.375 -1.10365303002648 1846030.0 27402.90322581 0.132126126517823 -0.9116 -0.691 2074899 Maybridge2_000482 Cc1cc(nn1C)C(=O)N2CCN=C(C=C2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F21 compound treatment 1265370.0 -179000.0 -0.88 1599630.0 -147000.0 -0.65 1344850.0 -175119.375 -0.912777931998212 1652560.0 -166067.09677419 -0.80071086110934 -1.621 -0.9926 2074900 Maybridge2_000483 Fc1ccccc1NC(=O)N2CCCC2c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F22 compound treatment 1477850.0 33600.0 0.16 1889140.0 142000.0 0.63 1472670.0 -47299.375 -0.246539400322254 1873440.0 54812.90322581 0.264286470916751 0.4064 0.5454 2074901 Maybridge2_000484 OC(CNCc1ccc(cc1)c2cccs2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F23 mock treatment 1429050.0 -15200.0 -0.07 1835260.0 88300.0 0.39 1634480.0 114510.625 0.596865832117792 1900640.0 82012.90322581 0.395434277106129 0.6548 0.7992 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 F24 mock treatment 1264970.0 -179000.0 -0.88 1867800.0 121000.0 0.54 1366080.0 -153889.375 -0.802120413397988 1923200.0 104572.90322581 0.504209810474965 -0.3196 -0.2286 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G01 compound treatment 1397850.0 -46400.0 -0.23 1657680.0 -89300.0 -0.4 1771140.0 251170.625 1.30918125802013 1530340.0 -288287.09677419 -1.39000809906764 -0.3518 -0.1792 2074902 Maybridge2_000485 CC(C)(C)NC(=O)N1CCCN(CC1)c2ccc(cn2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G02 compound treatment 1359010.0 -85200.0 -0.42 1184830.0 -562000.0 -2.49 1281510.0 -238459.375 -1.24292617637589 1516480.0 -302147.09677419 -1.45683562089796 -2.8048 -0.8845 2074903 Maybridge2_000486 CN(C)C(=O)Oc1ccnc(SCc2ccc(Cl)cc2Cl)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G03 compound treatment 1381400.0 -62800.0 -0.31 1180810.0 -566000.0 -2.51 1645880.0 125910.625 0.656286261323753 1254420.0 -564207.09677419 -2.72038687420635 -2.4411 -0.6471 2074904 Maybridge2_000487 COC(=O)C1Cc2c([nH]c3ccccc23)C(N1)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G04 compound treatment 1556160.0 112000.0 0.55 1321760.0 -425000.0 -1.89 1568420.0 48450.625 0.252540081824303 1457790.0 -360837.09677419 -1.73981594241467 -1.4126 -0.5359 2074905 Maybridge2_000488 O=C1CS(=O)(=O)C(N1CC2CC2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G05 compound treatment 1555410.0 111000.0 0.54 1293070.0 -454000.0 -2.01 1704600.0 184630.625 0.962353594917966 1649540.0 -169087.09677419 -0.815272124884778 -0.6609 -0.2712 1288613 Maybridge2_000489 C(NCc1cccnc1)c2ccco2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G06 compound treatment 1617380.0 173000.0 0.85 1353500.0 -393000.0 -1.74 1788920.0 268950.625 1.40185627830802 1555140.0 -263487.09677419 -1.27043215813026 -0.3831 -0.1414 2074906 Maybridge2_000490 ON=C1CC2CCCC(C1)N2Cc3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G07 compound treatment 1276850.0 -167000.0 -0.82 1090990.0 -656000.0 -2.91 1528590.0 8620.625 0.0449334418880383 1444610.0 -374017.09677419 -1.80336476909026 -2.7433 -0.7794 2074907 Maybridge2_000491 CN1CCN(CC1)c2ncnc3c2sc4nc(C)cc(C)c43 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G08 compound treatment 1612180.0 168000.0 0.82 1472670.0 -274000.0 -1.22 1655910.0 135940.625 0.708565814388296 1675330.0 -143297.09677419 -0.690922789530953 -0.1884 -0.1064 1401140 Maybridge2_000492 Brc1ccc(s1)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G09 compound treatment 1475780.0 31600.0 0.15 1608890.0 -138000.0 -0.61 1762010.0 242040.625 1.26159279147184 1476480.0 -342147.09677419 -1.64970004176469 -0.423 -0.1949 2074908 Maybridge2_000493 CC1CCN(CC1)C(=O)Nc2csc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G10 compound treatment 1470330.0 26100.0 0.13 1425870.0 -321000.0 -1.42 1832230.0 312260.625 1.62760178610716 1685460.0 -133167.09677419 -0.642079874946453 -0.1553 -0.0687 2074909 Maybridge2_000494 Ic1ccc(NC(=O)CN2CCCC2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G11 compound treatment 1489450.0 45200.0 0.22 1681290.0 -65700.0 -0.29 1828030.0 308060.625 1.60571004903128 1559930.0 -258697.09677419 -1.24733664373147 0.1442 0.0698 2074910 Maybridge2_000495 O=C(CN1CCCC1)N2CCc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G12 compound treatment 1387650.0 -56600.0 -0.28 1835840.0 88900.0 0.39 1709240.0 189270.625 0.986538752068462 1898880.0 80252.90322581 0.386948242587992 0.7454 0.6404 1615107 Maybridge2_000496 CN(C)CCC(O)c1ccc2OCCCCOc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G13 compound treatment 1743060.0 299000.0 1.46 1377470.0 -370000.0 -1.64 1734370.0 214400.625 1.11752431223915 1676830.0 -141797.09677419 -0.683690373748451 0.1288 0.0504 2074911 Maybridge2_000497 O=C(CN1CCN(CC1)c2ccccc2)N3CCCc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G14 compound treatment 722410.0 -722000.0 -3.53 814780.0 -932000.0 -4.13 870330.0 -649639.375 -3.38612723610458 893180.0 -925447.09677419 -4.4621454590538 -7.7572 -0.9937 1590454 Maybridge2_000498 CN(C)CCC(=O)Nc1nc(cs1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G15 compound treatment 1076210.0 -368000.0 -1.8 1277690.0 -469000.0 -2.08 1509980.0 -9989.375 -0.0520678026315171 1510480.0 -308147.09677419 -1.48576528402797 -2.7099 -0.8663 1327521 Maybridge2_000499 CCN(CC)c1ncnc2sc(cc12)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G16 compound treatment 1399200.0 -45000.0 -0.22 1674940.0 -72000.0 -0.32 1600540.0 80570.625 0.419959747271274 1635060.0 -183567.09677419 -0.885089045238535 -0.5024 -0.4768 2074912 Maybridge2_000500 CN(C)C(=O)Oc1cc(CSC(C)(C)C)nc(n1)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G17 compound treatment 1291570.0 -153000.0 -0.75 1806340.0 59400.0 0.26 1508380.0 -11589.375 -0.0604075119937573 1884560.0 65932.90322581 0.317902779917703 -0.1131 -0.1322 1511025 Maybridge2_000501 CCOC(=O)Cn1cnc2sc(cc2c1=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G18 compound treatment 1747090.0 303000.0 1.48 1610040.0 -137000.0 -0.61 1482360.0 -37609.375 -0.196032035497187 1771250.0 -47377.09677419 -0.228433908292531 0.2252 0.1382 2074913 Maybridge2_000502 Clc1ccc(CN(Cc2cccnc2)S(=O)(=O)c3ccc(Cl)cc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G19 compound treatment 1173820.0 -270000.0 -1.32 1662290.0 -84700.0 -0.38 1487450.0 -32519.375 -0.169501335088561 1478090.0 -340537.09677419 -1.64193724882481 -1.7551 -0.8168 2074914 Maybridge2_000503 Nc1c(sc2nsc(SCCN3CCOCC3)c12)C(=O)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G20 compound treatment 1746920.0 303000.0 1.48 1888000.0 141000.0 0.63 1535870.0 15900.625 0.0828791194862308 1822400.0 3772.90322581003 0.0181914698908019 1.1039 0.6856 2074915 Maybridge2_000504 CCN(Cc1cccc(Cl)c1Cl)C(=O)c2cnc(OC)cc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G21 compound treatment 1198260.0 -246000.0 -1.2 1466400.0 -281000.0 -1.24 1332890.0 -187079.375 -0.975117259480957 1588550.0 -230077.09677419 -1.10934215060133 -2.2661 -0.9959 2074916 Maybridge2_000505 CC1CCc2c(C#N)c(NC(=O)CN(Cc3ccccc3)Cc4ccccc4)sc2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G22 compound treatment 1283680.0 -161000.0 -0.79 1785640.0 38700.0 0.17 1540430.0 20460.625 0.106647291168615 1819620.0 992.903225810034 0.00478739264056404 -0.2513 -0.3099 2074917 Maybridge2_000506 CN(C)/C=C/C(=O)c1cc(cc(c1O)C(C)(C)C)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G23 mock treatment 1261920.0 -182000.0 -0.89 1762920.0 15900.0 0.07 1337120.0 -182849.375 -0.953069152854534 1927530.0 108902.90322581 0.525087384033789 -0.6246 -0.4434 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 G24 mock treatment 1603610.0 159000.0 0.78 1710010.0 -37000.0 -0.16 1582910.0 62940.625 0.32806657473609 1865630.0 47002.90322581 0.226629692742522 0.5854 0.6568 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H01 compound treatment 1370890.0 -73300.0 -0.36 1208640.0 -538000.0 -2.39 1525250.0 5280.625 0.027524298594362 1407420.0 -411207.09677419 -1.9826804643911 -2.3507 -0.7524 1462187 Maybridge2_000507 Fc1ccccc1CN2CCN(CC2)c3cccc4[nH]ccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H02 compound treatment 1522300.0 78100.0 0.38 1621640.0 -125000.0 -0.56 1662790.0 142820.625 0.744426564645928 1527650.0 -290977.09677419 -1.40297823137093 -0.4161 -0.2412 2074918 Maybridge2_000508 Cc1cccc(NC(=O)OC2CN3CCC2CC3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H03 compound treatment 1503400.0 59200.0 0.29 1116320.0 -631000.0 -2.8 1512800.0 -7169.375 -0.0373690648805689 1457250.0 -361377.09677419 -1.74241961209637 -2.1435 -0.6479 1623409 Maybridge2_000509 CN1CCN(CC1)c2cc(nc3ccccc23)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H04 compound treatment 1530760.0 86600.0 0.42 1308920.0 -438000.0 -1.94 1728120.0 208150.625 1.0849473225429 1547470.0 -271157.09677419 -1.30741391083146 -0.8708 -0.333 2074919 Maybridge2_000510 FC(F)(F)c1cccc(CS(=O)(=O)N2CCCCC2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H05 compound treatment 1348000.0 -96200.0 -0.47 1335460.0 -412000.0 -1.82 1468010.0 -51959.375 -0.270828803839778 1343840.0 -474787.09677419 -2.28923846135877 -2.4279 -0.8154 2074920 Maybridge2_000511 CN(C)C(=O)Oc1cc(C)nc(n1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H06 compound treatment 1530470.0 86300.0 0.42 1330590.0 -416000.0 -1.85 1658980.0 139010.625 0.724567631727094 1358760.0 -459867.09677419 -2.21730003237548 -1.4586 -0.4854 2074921 Maybridge2_000512 O=C(N1CCC(=CC1)c2ccccc2)c3ccsc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H07 compound treatment 1518080.0 73900.0 0.36 1433840.0 -313000.0 -1.39 1455420.0 -64549.375 -0.336451891883905 1664990.0 -153637.09677419 -0.740778242325003 -1.0522 -0.6379 2074922 Maybridge2_000513 CC(C)CCc1c(C)nc(nc1O)N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H08 compound treatment 1611390.0 167000.0 0.82 1244430.0 -503000.0 -2.23 1754030.0 234060.625 1.21999849102767 1384970.0 -433657.09677419 -2.09092562060256 -1.1408 -0.3364 2074923 Maybridge2_000514 Clc1cc(Cl)cc(c1)S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H09 compound treatment 1441450.0 -2760.0 -0.01 1216570.0 -530000.0 -2.35 1724970.0 205000.625 1.06852851973599 1483600.0 -335027.09677419 -1.61537017485041 -1.4563 -0.4779 2074924 Maybridge2_000515 CCCc1cc(OC(=O)N(C)C)nc(n1)c2cccc(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H10 compound treatment 1468320.0 24100.0 0.12 1394890.0 -352000.0 -1.56 1797040.0 277070.625 1.44418030332139 1585200.0 -233427.09677419 -1.12549454584892 -0.5624 -0.2334 2074925 Maybridge2_000516 COc1ccc(c(OC)c1)S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H11 compound treatment 1251270.0 -193000.0 -0.94 1502090.0 -245000.0 -1.09 1611200.0 91230.625 0.475523060897199 1470670.0 -347957.09677419 -1.67771359889558 -1.6162 -0.7148 2074926 Maybridge2_000517 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H12 compound treatment 1547140.0 103000.0 0.5 1652570.0 -94400.0 -0.42 1513820.0 -6149.375 -0.0320525001621408 1836000.0 17372.90322581 0.0837653729854906 0.0684 0.1034 2074927 Maybridge2_000518 Fc1ccc(CN2CCCN(Cc3ccc(F)cc3)C2c4ccco4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H13 compound treatment 1854840.0 411000.0 2.01 1783850.0 36900.0 0.16 1810820.0 290850.625 1.51600605020368 1664270.0 -154357.09677419 -0.744249801900604 1.4723 0.5598 1939214 Maybridge2_000519 COc1ccc(cc1)N2C(=O)CC(N3CCSCC3)C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H14 compound treatment 1364120.0 -80100.0 -0.39 1898760.0 152000.0 0.67 1900270.0 380300.625 1.98224792673642 1849450.0 30822.90322581 0.148616034501929 1.206 0.5649 2074928 Maybridge2_000520 CC1(C)Cc2cccc(C(=O)N3CCC(O)(CC3)c4ccc(Cl)cc4)c2O1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H15 compound treatment 1239930.0 -204000.0 -1.0 1728010.0 -19000.0 -0.08 1557160.0 37190.625 0.193849377187538 1921250.0 102622.90322581 0.494807669957712 -0.1975 -0.174 2074929 Maybridge2_000521 O=C1CC2(CCCc3ccccc32)C(=O)N1CN4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H16 compound treatment 1415520.0 -28700.0 -0.14 1878080.0 131000.0 0.58 1687910.0 167940.625 0.875360001633098 2032810.0 214182.90322581 1.03270653975503 1.1745 0.7936 2074930 Maybridge2_000522 Cc1cc(CN2CCS(=O)(=O)CC2)no1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H17 compound treatment 1231860.0 -212000.0 -1.04 1672260.0 -74700.0 -0.33 1568370.0 48400.625 0.252279465906733 1770080.0 -48547.09677419 -0.234075192602883 -0.6761 -0.5912 2074931 Maybridge2_000523 CC(=O)N1CCC(CC1)C(=O)NCc2ccc(cc2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H18 compound treatment 1232320.0 -212000.0 -1.04 1584590.0 -162000.0 -0.72 1603290.0 83320.625 0.434293622737624 1646960.0 -171667.09677419 -0.827711880030682 -1.0752 -0.6845 2074932 Maybridge2_000524 OC1(CCN(CC1)C(=O)c2cnc3ccccc3n2)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H19 compound treatment 1457880.0 13700.0 0.07 1861730.0 115000.0 0.51 1409030.0 -110939.375 -0.578251340205355 1781250.0 -37377.09677419 -0.180217803075848 -0.0913 -0.115 2074933 Maybridge2_000525 Fc1ccc(cc1)C2CCCN2S(=O)(=O)c3ccc(Oc4ccccc4)nc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H20 compound treatment 1745090.0 301000.0 1.47 1888000.0 141000.0 0.63 1746310.0 226340.625 1.17975939335486 1930340.0 111712.90322581 0.538636109599677 1.9081 0.9265 2074934 Maybridge2_000526 Cc1cc(nn1C)C(=O)Nc2ccccc2N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H21 compound treatment 1243950.0 -200000.0 -0.98 1861600.0 115000.0 0.51 1539550.0 19580.625 0.102060451019383 1898980.0 80352.90322581 0.387430403640159 0.0089 0.0076 2074935 Maybridge2_000527 Cc1cccc(NC(=O)N2CCCC2c3cccnc3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H22 compound treatment 1471620.0 27400.0 0.13 1850840.0 104000.0 0.46 1404640.0 -115329.375 -0.601133417768001 1977640.0 159012.90322581 0.766698287274587 0.3802 0.3501 2074936 Maybridge2_000528 O=C(NCc1ccsc1)C2CCCCN2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H23 mock treatment 1456000.0 11800.0 0.06 1923540.0 177000.0 0.78 1509030.0 -10939.375 -0.0570195050653472 1915960.0 97332.90322581 0.469301350298087 0.6265 0.6836 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 H24 mock treatment 1651220.0 207000.0 1.01 1816070.0 69100.0 0.31 1632000.0 112030.625 0.58393928260632 1871630.0 53002.90322581 0.255559355872532 1.0795 0.8737 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I01 compound treatment 1391130.0 -53100.0 -0.26 1344360.0 -403000.0 -1.79 1637470.0 117500.625 0.612450663988479 1600820.0 -217807.09677419 -1.05018098950046 -1.2415 -0.5706 2074937 Maybridge2_000529 Cc1ccc(F)cc1NC(=O)N2CCCN(CC2)c3ccc(cn3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I02 compound treatment 1444190.0 -18.4 0.0 1708160.0 -38800.0 -0.17 1736410.0 216440.625 1.128157441676 1642970.0 -175657.09677419 -0.846950106012139 0.0545 0.0383 2074938 Maybridge2_000530 COc1cc(/N=C(/SCc2c(C)c(C)c(C)c(C)c2C)\N3CCOCC3)c(OC)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I03 compound treatment 1502590.0 58400.0 0.29 1153470.0 -594000.0 -2.63 1685050.0 165080.625 0.860452771148094 1376830.0 -441797.09677419 -2.13017353024894 -1.808 -0.5158 2074939 Maybridge2_000531 Clc1cccnc1N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I04 compound treatment 1572090.0 128000.0 0.63 1424730.0 -322000.0 -1.43 1612400.0 92430.625 0.481777842918879 1425250.0 -393377.09677419 -1.89671114878976 -1.1091 -0.4432 2074940 Maybridge2_000532 CN(C)C(=O)CS(=O)(=O)c1ccc(Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I05 compound treatment 1614080.0 170000.0 0.83 1527200.0 -220000.0 -0.97 1468890.0 -51079.375 -0.266241963690546 1386480.0 -432147.09677419 -2.08364498871484 -1.2466 -0.5067 2074941 Maybridge2_000533 O=C(NC1CCCCC1)C2N(Cc3ccco3)C(=O)c4ccccc24 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I06 compound treatment 1520800.0 76600.0 0.37 1261040.0 -486000.0 -2.16 1846580.0 326610.625 1.70239855444975 1417520.0 -401107.09677419 -1.93398219812225 -1.0059 -0.2976 1575317 Maybridge2_000534 O=C(Nc1ccccc1)OC2CN(C2)C(c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I07 compound treatment 1319520.0 -125000.0 -0.61 1151200.0 -596000.0 -2.64 1373250.0 -146719.375 -0.76474809081845 1300130.0 -518497.09677419 -2.49999105726089 -3.2585 -0.8651 1985907 Maybridge2_000535 CCN(CC)c1ncnc2c1sc3nc(C)cc(C)c32 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I08 compound treatment 1481080.0 36900.0 0.18 1336440.0 -411000.0 -1.82 1780760.0 260790.625 1.3593237605606 1642330.0 -176297.09677419 -0.850035936746006 -0.5655 -0.2324 1203540 Maybridge2_000536 O=S(=O)(N1CCN(Cc2ccccc2)CC1)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I09 compound treatment 1686120.0 242000.0 1.18 1294080.0 -453000.0 -2.01 1783520.0 263550.625 1.37370975921046 1665060.0 -153567.09677419 -0.740440729588486 -0.0957 -0.0341 2074942 Maybridge2_000537 CN1CCC(CNC(=O)Nc2csc3ccccc23)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I10 compound treatment 1658050.0 214000.0 1.05 1515480.0 -231000.0 -1.03 1856830.0 336860.625 1.7558248175516 1583130.0 -235497.09677419 -1.13547527962877 0.3201 0.1253 1098492 Maybridge2_000538 Ic1ccc(NC(=O)CN2CCCCC2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I11 compound treatment 1809760.0 366000.0 1.79 1425540.0 -321000.0 -1.43 1889550.0 369580.625 1.92637187400941 1648640.0 -169987.09677419 -0.819611574354279 0.735 0.2371 2074943 Maybridge2_000539 O=C(CN1CCN(CC1)c2ccccc2)N3CCc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I12 compound treatment 1488600.0 44400.0 0.22 1983910.0 237000.0 1.05 1860320.0 340350.625 1.77401580859799 2007910.0 189282.90322581 0.912648437765486 1.9773 0.8729 2074944 Maybridge2_000540 O=c1[nH]c2ccccc2c(=O)n1CCN3CCSCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I13 compound treatment 1375140.0 -69100.0 -0.34 1849860.0 103000.0 0.46 1837820.0 317850.625 1.65673864569148 1747650.0 -70977.09677419 -0.342223916603903 0.7164 0.4015 2074945 Maybridge2_000541 CCN(CC)c1ncc(C#N)c(N)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I14 compound treatment 1278920.0 -165000.0 -0.81 1245300.0 -502000.0 -2.22 1197800.0 -322169.375 -1.67924934557159 1494520.0 -324107.09677419 -1.5627181879538 -3.1378 -0.9519 1477602 Maybridge2_000542 Clc1ccc(cc1)c2csc(NC(=O)CCN3CCCC3)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I15 compound treatment 1271550.0 -173000.0 -0.84 1232010.0 -515000.0 -2.28 1266630.0 -253339.375 -1.32048547344473 1540160.0 -278467.09677419 -1.34265988374486 -2.8959 -0.9408 1285881 Maybridge2_000543 C1CCN(C1)c2ncnc3sc(cc23)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I16 compound treatment 1566330.0 122000.0 0.6 1940350.0 193000.0 0.86 1729980.0 210010.625 1.0946422346765 1858500.0 39872.90322581 0.192251609723027 1.371 0.8986 2074946 Maybridge2_000544 CN1CSc2nc(C)cc(C)c2C1=N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I17 compound treatment 1388220.0 -56000.0 -0.27 1666670.0 -80300.0 -0.36 1400000.0 -119969.375 -0.625318574918498 1783540.0 -35087.09677419 -0.169176314981228 -0.7123 -0.9035 2074947 Maybridge2_000545 CCOC(=O)c1cc(sc1NC(=O)CN2CCc3ccccc23)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I18 compound treatment 1484800.0 40600.0 0.2 1902440.0 155000.0 0.69 1585700.0 65730.625 0.342608942936497 1981010.0 162382.90322581 0.782947114732609 1.0068 0.9023 2074948 Maybridge2_000546 CN(C)C(=O)Nc1cnccc1C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I19 compound treatment 1186950.0 -257000.0 -1.26 1594240.0 -153000.0 -0.68 1343840.0 -176129.375 -0.918042373533126 1415780.0 -402847.09677419 -1.94237180042996 -2.3983 -0.9294 2074949 Maybridge2_000547 Nc1c(sc2nsc(SCCN3CCOCC3)c12)C(=O)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I20 compound treatment 1657720.0 214000.0 1.04 1782120.0 35100.0 0.16 1781190.0 261220.625 1.3615650574517 1827610.0 8982.90322581003 0.0433120607086936 1.3028 0.7557 2074950 Maybridge2_000548 COc1cc(c(cn1)C(=O)N(C)Cc2ccc(Cl)c(Cl)c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I21 compound treatment 1365180.0 -79000.0 -0.39 1879440.0 132000.0 0.59 1485780.0 -34189.375 -0.178205906735399 1569570.0 -249057.09677419 -1.20085631830259 -0.5892 -0.4199 1531885 Maybridge2_000549 C1C(CN1C(c2ccccc2)c3ccccc3)Oc4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I22 compound treatment 1380770.0 -63400.0 -0.31 1874720.0 128000.0 0.57 862890.0 -657079.375 -3.42490688463899 1751110.0 -67517.09677419 -0.32554114419893 -1.7472 -0.4991 2074951 Maybridge2_000550 COc1ccc2nccc([C@@H](O)C3CC4CCN3CC4C=C)c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I23 mock treatment 1408760.0 -35400.0 -0.17 1788890.0 41900.0 0.19 1406200.0 -113769.375 -0.593002201139817 1820320.0 1692.90322581003 0.00816252000573184 -0.2862 -0.4436 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 I24 mock treatment 1428010.0 -16200.0 -0.08 1785320.0 38300.0 0.17 1624960.0 104990.625 0.547244561412464 1947650.0 129022.90322581 0.622098187729755 0.6301 0.7417 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J01 compound treatment 1564670.0 120000.0 0.59 1531430.0 -216000.0 -0.96 1662760.0 142790.625 0.744270195095387 1345600.0 -473027.09677419 -2.28075242684064 -0.9515 -0.3592 1277060 Maybridge2_000551 Clc1ccc(CN2CCN(CC2)c3cccc4[nH]ccc34)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J02 compound treatment 1535310.0 91100.0 0.45 1624640.0 -122000.0 -0.54 1588200.0 68230.625 0.355639738814997 1712640.0 -105987.09677419 -0.511028500967509 -0.1261 -0.1343 2074952 Maybridge2_000552 FC(F)(F)c1cccc(NC(=O)OC2CN3CCC2CC3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J03 compound treatment 1461280.0 17100.0 0.08 1085760.0 -661000.0 -2.93 1411680.0 -108289.375 -0.564438696574145 1231300.0 -587327.09677419 -2.83186250946732 -3.1225 -0.7586 1317869 Maybridge2_000553 CN1CCN(CC1)c2c3CCc4ccccc4-c3nc5ccccc25 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J04 compound treatment 1588330.0 144000.0 0.71 1265320.0 -482000.0 -2.14 1581610.0 61640.625 0.32129056087927 1595060.0 -223567.09677419 -1.07795346610527 -1.0937 -0.4349 2074953 Maybridge2_000554 CN1CCN(CC1)S(=O)(=O)Cc2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J05 compound treatment 1677640.0 233000.0 1.14 1264550.0 -482000.0 -2.14 1404060.0 -115909.375 -0.604156562411813 1774590.0 -44037.09677419 -0.212329729150159 -0.9068 -0.3615 2074954 Maybridge2_000555 CC1CN(CC(C)O1)c2nc(O)cc(n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J06 compound treatment 1687530.0 243000.0 1.19 1327040.0 -420000.0 -1.86 1796820.0 276850.625 1.44303359328408 1331910.0 -486717.09677419 -2.34676027488228 -0.7877 -0.223 2074955 Maybridge2_000556 O=C(N1CCC(=CC1)c2ccccc2)c3ccc4OCCc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J07 compound treatment 1419210.0 -25000.0 -0.12 1354300.0 -393000.0 -1.74 1779760.0 259790.625 1.3541114422092 1388590.0 -430037.09677419 -2.07347139051412 -1.2916 -0.4263 2074956 Maybridge2_000557 CC(C)CCc1c(C)nc(nc1O)N2CCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J08 compound treatment 1429870.0 -14300.0 -0.07 1484320.0 -263000.0 -1.16 1779280.0 259310.625 1.35160952940052 1569800.0 -248827.09677419 -1.19974734788261 -0.5416 -0.2517 2074957 Maybridge2_000558 O=S(=O)(N1CCC(=CC1)c2ccccc2)c3ccc4OCCc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J09 compound treatment 1321760.0 -122000.0 -0.6 1694810.0 -52200.0 -0.23 1567390.0 47420.625 0.247171393922361 1849200.0 30572.90322581 0.147410631871512 -0.218 -0.3097 2074958 Maybridge2_000559 Oc1ccccc1/C=N/c2ccc(cc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J10 compound treatment 1532350.0 88100.0 0.43 1446930.0 -300000.0 -1.33 1817180.0 297210.625 1.54915639491859 1528740.0 -289887.09677419 -1.39772267590231 -0.3739 -0.1489 2074959 Maybridge2_000560 Clc1ccc(CS(=O)(=O)N2CCCCCC2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J11 compound treatment 1444500.0 292.0 0.0 1514560.0 -232000.0 -1.03 1859870.0 339900.625 1.77167026533986 1512990.0 -305637.09677419 -1.47366304161858 -0.3656 -0.1448 2074960 Maybridge2_000561 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2cc(ccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J12 compound treatment 1401220.0 -43000.0 -0.21 1729120.0 -17900.0 -0.08 1593510.0 73540.625 0.383317149260931 1753180.0 -65447.09677419 -0.315560410419077 -0.1109 -0.2035 2074961 Maybridge2_000562 Fc1ccc(CN2CCCN(Cc3ccc(F)cc3)C2c4cccnc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J13 compound treatment 1666180.0 222000.0 1.09 1951390.0 204000.0 0.91 1729720.0 209750.625 1.09328703190514 1802360.0 -16267.09677419 -0.0784336049634306 1.5038 0.8402 2074962 Maybridge2_000563 Cc1ccc(N2C(=O)CC(N3CCSCC3)C2=O)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J14 compound treatment 1600360.0 156000.0 0.76 1751680.0 4700.0 0.02 1832610.0 312640.625 1.62958246708069 1571230.0 -247397.09677419 -1.19285244483662 0.6109 0.2829 2074963 Maybridge2_000564 Fc1ccc(cc1)N2CCN(CC2)C(=O)c3cc(F)cc4COCOc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J15 compound treatment 1498760.0 54600.0 0.27 1815100.0 68100.0 0.3 1770610.0 250640.625 1.30641872929388 1614880.0 -203747.09677419 -0.982389145565801 0.4465 0.2652 2074964 Maybridge2_000565 Oc1cc2OCOc2cc1C(N3CCCC3)c4ccc(cc4)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J16 compound treatment 1392000.0 -52200.0 -0.26 1600180.0 -147000.0 -0.65 1435900.0 -84069.375 -0.438196346103235 1470430.0 -348197.09677419 -1.67887078542078 -1.5118 -0.8081 2074965 Maybridge2_000566 O=S1(=O)CCN(Cc2csc(n2)c3cccs3)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J17 compound treatment 1446410.0 2200.0 0.01 1831010.0 84000.0 0.37 1542560.0 22590.625 0.117749529257097 1644340.0 -174287.09677419 -0.840344499597453 -0.1696 -0.183 2074966 Maybridge2_000567 CC(=O)N1CCC(CC1)C(=O)NCc2cc3ccccc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J18 compound treatment 1484210.0 40000.0 0.2 1810970.0 64000.0 0.28 1776740.0 256770.625 1.33837024078797 1856170.0 37542.90322581 0.18101725720754 0.9995 0.717 2074967 Maybridge2_000568 O=C(N(Cc1ccccn1)Cc2ccccn2)c3csc(n3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J19 compound treatment 1293510.0 -151000.0 -0.74 1669370.0 -77600.0 -0.34 1468040.0 -51929.375 -0.270672434289236 1709770.0 -108857.09677419 -0.524866523164697 -0.9386 -0.9334 2074968 Maybridge2_000569 Cc1c(cnn1c2ccccc2)S(=O)(=O)N3CCCC3c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J20 compound treatment 1765080.0 321000.0 1.57 1795300.0 48300.0 0.21 1414120.0 -105849.375 -0.551720639796728 1316010.0 -502617.09677419 -2.4234238821768 -0.5953 -0.202 2074969 Maybridge2_000570 OC(CN1CCCN(CC1)c2nc(ns2)c3ccccc3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J21 compound treatment 1586560.0 142000.0 0.7 1796250.0 49300.0 0.22 1762720.0 242750.625 1.26529353750134 1565330.0 -253297.09677419 -1.22129994691446 0.4795 0.2519 2074970 Maybridge2_000571 FC(F)(F)c1ccccc1NC(=O)N2CCCC2c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J22 compound treatment 1320440.0 -124000.0 -0.61 1797450.0 50500.0 0.22 1427200.0 -92769.375 -0.483543515760415 1908530.0 89902.90322581 0.433476784122091 -0.2159 -0.2358 2074971 Maybridge2_000572 Clc1cccc(c1)N2CCN(CC2)C(=O)c3cnc4ccccc4n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J23 mock treatment 1534960.0 90800.0 0.44 1769720.0 22700.0 0.1 1443100.0 -76869.375 -0.400667653973154 1834720.0 16092.90322581 0.0775937115177552 0.1109 0.1814 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 J24 mock treatment 1633660.0 189000.0 0.93 1783370.0 36400.0 0.16 1569560.0 49590.625 0.258482124744899 1606180.0 -212447.09677419 -1.02433715710431 0.1613 0.114 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K01 compound treatment 1542560.0 98400.0 0.48 1645080.0 -102000.0 -0.45 1742610.0 222640.625 1.16047381545468 1723040.0 -95587.09677419 -0.460883751542159 0.3645 0.2581 2074972 Maybridge2_000573 CN(C)c1ccc(cc1)C(=O)Nc2ccc(Oc3c(Cl)cccc3Cl)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K02 compound treatment 1688130.0 244000.0 1.19 1332320.0 -415000.0 -1.84 1825730.0 305760.625 1.59372171682306 1470560.0 -348067.09677419 -1.67824397605297 -0.3649 -0.1145 2074973 Maybridge2_000574 CC(C)c1ccc(/N=C(/SCc2c(C)c(C)c(C)c(C)c2C)\N3CCOCC3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K03 compound treatment 1563280.0 119000.0 0.58 1373030.0 -374000.0 -1.66 1797090.0 277120.625 1.44444091923896 1493490.0 -325137.09677419 -1.56768444679111 -0.5995 -0.217 2074974 Maybridge2_000575 Cc1nnsc1C(=O)N2CCC(O)(CC2)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K04 compound treatment 1497020.0 52800.0 0.26 1202080.0 -545000.0 -2.42 1697020.0 177050.625 0.922844221814353 1427070.0 -391557.09677419 -1.88793581764032 -1.5616 -0.486 2074975 Maybridge2_000576 Clc1ccc(cc1)S(=O)(=O)/C(=C/NN2CCCCC2)/C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K05 compound treatment 1602980.0 159000.0 0.78 1413020.0 -334000.0 -1.48 1724390.0 204420.625 1.06550537509217 1322440.0 -496187.09677419 -2.39242092652247 -1.0155 -0.3268 2074976 Maybridge2_000577 Cn1cnc2n(ncc2c1=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K06 compound treatment 1434840.0 -9370.0 -0.05 1843360.0 96400.0 0.43 1756570.0 236600.625 1.23323777964023 1850130.0 31502.90322581 0.151894729656663 0.8834 0.6719 1199768 Maybridge2_000578 Clc1ccc(NC(=O)OC2CN(C2)C(c3ccccc3)c4ccccc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K07 compound treatment 1115200.0 -329000.0 -1.61 1094770.0 -652000.0 -2.89 1264490.0 -255479.375 -1.33163983471672 1182560.0 -636067.09677419 -3.06686780629343 -4.4504 -0.9459 2074977 Maybridge2_000579 Cc1cc(C)c2c(n1)sc3c(ncnc32)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K08 compound treatment 1485240.0 41000.0 0.2 1447850.0 -299000.0 -1.33 1832750.0 312780.625 1.63031219164989 1265770.0 -552857.09677419 -2.66566159478542 -1.0806 -0.3178 1679524 Maybridge2_000580 Clc1ccc(s1)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K09 compound treatment 1475220.0 31000.0 0.15 1468960.0 -278000.0 -1.23 1763440.0 243470.625 1.26904640671435 1550900.0 -267727.09677419 -1.29087578674214 -0.5515 -0.2512 2074978 Maybridge2_000581 O=C(Nc1csc2ccccc12)N3CCSCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K10 compound treatment 1546240.0 102000.0 0.5 1626800.0 -120000.0 -0.53 1782370.0 262400.625 1.36771559310635 1572170.0 -246457.09677419 -1.18832013094625 0.0729 0.0373 1024901 Maybridge2_000582 Oc1ccc2ccccc2c1C(N3CCCCC3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K11 compound treatment 1545730.0 102000.0 0.5 1804840.0 57900.0 0.26 1875170.0 355200.625 1.85141873611628 1797730.0 -20897.09677419 -0.100757661678755 1.252 0.6465 2074979 Maybridge2_000583 CN1CCN(CC(=O)N2CCc3ccccc23)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K12 compound treatment 1370640.0 -73600.0 -0.36 1676410.0 -70600.0 -0.31 1755160.0 235190.625 1.22588841076475 1643360.0 -175267.09677419 -0.845069677908688 -0.1461 -0.0934 1117813 Maybridge2_000584 Clc1ccc(cc1)c2nc3cc(CN4CCCCC4)ccc3o2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K13 compound treatment 1824270.0 380000.0 1.86 1661680.0 -85300.0 -0.38 1714140.0 194170.625 1.01207911199032 1730560.0 -88067.09677419 -0.424625240419214 1.0345 0.4719 2074980 Maybridge2_000585 Nc1nc(ncc1C#N)N(Cc2ccccc2)Cc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K14 compound treatment 1520970.0 76800.0 0.38 1631530.0 -115000.0 -0.51 1744840.0 224870.625 1.1720972853783 1868820.0 50192.90322581 0.242010630306644 0.6389 0.4716 2074981 Maybridge2_000586 Cc1cc(Br)ccc1NC(=O)CN2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K15 compound treatment 1315520.0 -129000.0 -0.63 1680710.0 -66300.0 -0.29 1509520.0 -10449.375 -0.0544654690731612 1553660.0 -264967.09677419 -1.27756814170233 -1.1278 -0.7749 1696248 Maybridge2_000587 C1CN(CCO1)c2ncnc3sc(cc23)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K16 compound treatment 1304810.0 -139000.0 -0.68 1586210.0 -161000.0 -0.71 1534080.0 14110.625 0.0735490696372247 1619270.0 -199357.09677419 -0.961222275375677 -1.1414 -0.8274 2074982 Maybridge2_000588 Cc1nc(C)nc(n1)N(Cc2ccccc2)Cc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K17 compound treatment 1291780.0 -152000.0 -0.75 1985660.0 239000.0 1.06 1764230.0 244260.625 1.27316413821195 1808980.0 -9647.09677418997 -0.0465145433099865 0.7696 0.4237 2074983 Maybridge2_000589 CCOC(=O)c1cc(sc1NC(=O)CN2CCCCC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K18 compound treatment 1458310.0 14100.0 0.07 1901170.0 154000.0 0.68 1469060.0 -50909.375 -0.265355869570808 1909390.0 90762.90322581 0.437623369170726 0.4625 0.5398 2074984 Maybridge2_000590 CN(Cc1ccccc1Cl)C(=O)c2cnccc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K19 compound treatment 925630.0 -519000.0 -2.54 1302120.0 -445000.0 -1.97 1209570.0 -310399.375 -1.61790035857561 1038450.0 -780177.09677419 -3.76171009857105 -4.945 -0.9499 2074985 Maybridge2_000591 Nc1c(sc2nsc(SCCN3CCCC3)c12)C(=O)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K20 compound treatment 1332400.0 -112000.0 -0.55 1650760.0 -96200.0 -0.43 1310130.0 -209839.375 -1.09374962515882 1595290.0 -223337.09677419 -1.07684449568528 -1.5722 -0.9334 2074986 Maybridge2_000592 CN(Cc1c(C)cc(Cl)cc1Cl)C(=O)c2cnc(Oc3ccccc3)cc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K21 compound treatment 1184430.0 -260000.0 -1.27 1338190.0 -409000.0 -1.81 1261120.0 -258849.375 -1.34920534756094 1554810.0 -263817.09677419 -1.27202328960241 -2.8526 -0.9877 1684983 Maybridge2_000593 Fc1ccc2[nH]c3CCN(Cc4ccc(Cl)cc4Cl)Cc3c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K22 compound treatment 1481720.0 37500.0 0.18 1645560.0 -101000.0 -0.45 1521310.0 1340.625 0.00698776428984573 1672490.0 -146137.09677419 -0.704616163412491 -0.4819 -0.5631 1305796 Maybridge2_000594 Cc1cc(C)c(OC2CN(C2)C(c3ccccc3)c4ccccc4)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K23 mock treatment 1545050.0 101000.0 0.49 1764530.0 17600.0 0.08 1684050.0 164080.625 0.855240452796694 1879600.0 60972.90322581 0.293987591730228 0.8603 0.8327 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 K24 mock treatment 1299910.0 -144000.0 -0.71 1758400.0 11400.0 0.05 1458690.0 -61279.375 -0.319407610874827 1835060.0 16432.90322581 0.0792330590951224 -0.4478 -0.5736 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L01 compound treatment 1570880.0 127000.0 0.62 1725030.0 -21900.0 -0.1 1768320.0 248350.625 1.29448252026918 1343780.0 -474847.09677419 -2.28952775799007 -0.2363 -0.0874 1614244 Maybridge2_000595 C(N1CCN(CC1)c2cccc3[nH]ccc23)c4ccc5ccccc5c4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L02 compound treatment 1442430.0 -1780.0 -0.01 798490.0 -948000.0 -4.21 1211110.0 -308859.375 -1.60987338831446 1328000.0 -490627.09677419 -2.365612772022 -4.0952 -0.805 2074987 Maybridge2_000596 FC(F)(F)c1ccc(NC(=O)OC2CN3CCC2CC3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L03 compound treatment 1578890.0 135000.0 0.66 1650000.0 -97000.0 -0.43 1555430.0 35460.625 0.184832066439616 1636000.0 -182627.09677419 -0.880556731348167 -0.2334 -0.1952 1550156 Maybridge2_000597 CC1C(N(C)C(CC1(O)c2ccc(F)cc2)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L04 compound treatment 1551520.0 107000.0 0.53 1359110.0 -388000.0 -1.72 1681120.0 161150.625 0.839968360027092 1296800.0 -521827.09677419 -2.51604702029805 -1.4355 -0.4479 2074988 Maybridge2_000598 O=S(=O)(N1CCC(=CC1)c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L05 compound treatment 1517000.0 72800.0 0.36 1442370.0 -305000.0 -1.35 1854290.0 334320.625 1.74258552893904 1513760.0 -304867.09677419 -1.4699504015169 -0.361 -0.135 2074989 Maybridge2_000599 Oc1cc(nc(n1)N2CCCC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L06 compound treatment 1749540.0 305000.0 1.49 1371400.0 -376000.0 -1.67 1669280.0 149310.625 0.778254510746515 1417130.0 -401497.09677419 -1.9358626262257 -0.6645 -0.2172 2074990 Maybridge2_000600 O=C(N1CCC(=CC1)c2ccccc2)c3ccc(s3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L07 compound treatment 1450520.0 6310.0 0.03 1705440.0 -41500.0 -0.18 1623040.0 103070.625 0.537236910177776 1681210.0 -137417.09677419 -0.662571719663543 -0.1393 -0.1596 2074991 Maybridge2_000601 CC(=C)Cc1c(C)nc(nc1O)N2CCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L08 compound treatment 1484110.0 39900.0 0.2 1790240.0 43300.0 0.19 1665770.0 145800.625 0.759959273333101 1738520.0 -80107.09677419 -0.386245220666734 0.3804 0.4249 2074992 Maybridge2_000602 Cc1cc(c(o1)C(F)(F)F)S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L09 compound treatment 1666770.0 223000.0 1.09 1659400.0 -87600.0 -0.39 1725440.0 205470.625 1.07097830936114 1470110.0 -348517.09677419 -1.68041370078772 0.0456 0.0198 2074993 Maybridge2_000603 C1CN=C(Nc2ccc(cc2)N3CCOCC3)S1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L10 compound treatment 1370180.0 -74000.0 -0.36 1528770.0 -218000.0 -0.97 1608410.0 88440.625 0.460980692696792 1669930.0 -148697.09677419 -0.716959486347962 -0.793 -0.592 2074994 Maybridge2_000604 CN1CCN(CC1)S(=O)(=O)Cc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L11 compound treatment 1367290.0 -76900.0 -0.38 1785980.0 39000.0 0.17 1711560.0 191590.625 0.99863133064371 1875200.0 56572.90322581 0.272772505434887 0.534 0.4789 1233213 Maybridge2_000605 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2ccc(F)cc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L12 compound treatment 1680970.0 237000.0 1.16 1746900.0 -75.9 0.0 1763440.0 243470.625 1.26904640671435 1621020.0 -197607.09677419 -0.952784456962758 0.7372 0.3752 2074995 Maybridge2_000606 Fc1ccc(CN2CCCN(Cc3ccc(F)cc3)C2c4cccs4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L13 compound treatment 1717920.0 274000.0 1.34 1887610.0 141000.0 0.62 1884480.0 364510.625 1.89994541996781 1665510.0 -153117.09677419 -0.738271004853736 1.5624 0.6206 2074996 Maybridge2_000607 Cc1cccc(C)c1N2C(=O)CC(N3CCSCC3)C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L14 compound treatment 1382740.0 -61500.0 -0.3 1613850.0 -133000.0 -0.59 1694790.0 174820.625 0.911220751890731 1701310.0 -117317.09677419 -0.565657348178011 -0.2728 -0.2164 2074997 Maybridge2_000608 O=C(N1CCSCC1)c2cccc3OCCCOc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L15 compound treatment 1734320.0 290000.0 1.42 1714900.0 -32100.0 -0.14 1781050.0 261080.625 1.3608353328825 1618490.0 -200137.09677419 -0.964983131582578 0.8366 0.3811 2074998 Maybridge2_000609 CN(C)/C=C/1\C(=O)N(C(=O)\C1=N\c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L16 compound treatment 1281550.0 -163000.0 -0.8 1871520.0 125000.0 0.55 1576810.0 56840.625 0.29627143279255 1610210.0 -208417.09677419 -1.00490606670199 -0.4761 -0.3337 2074999 Maybridge2_000610 O=S1(=O)CCN(Cc2cc3ccccc3s2)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L17 compound treatment 1280820.0 -163000.0 -0.8 1943310.0 196000.0 0.87 1599710.0 79740.625 0.415633523039612 2008060.0 189432.90322581 0.913371679343736 0.7001 0.4515 2075000 Maybridge2_000611 CC(=O)N1CCC(CC1)C(=O)Nc2cc(C)cc(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L18 compound treatment 1684730.0 241000.0 1.18 1833920.0 86900.0 0.39 1553600.0 33630.625 0.175293523856554 1791170.0 -27457.09677419 -0.132387426700899 0.8027 0.6382 2075001 Maybridge2_000612 O=S(=O)(NCCN1CCCC1)c2cc3ccccc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L19 compound treatment 1316320.0 -128000.0 -0.63 1921020.0 174000.0 0.77 1633340.0 113370.625 0.590923789197196 1933790.0 115162.90322581 0.555270665899432 0.6461 0.5038 2075002 Maybridge2_000613 O=S(=O)(N1CCCC1c2cccnc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L20 compound treatment 1744570.0 300000.0 1.47 1759080.0 12100.0 0.05 1630400.0 110430.625 0.57559957324408 1604320.0 -214307.09677419 -1.03330535267462 0.5329 0.2823 2075003 Maybridge2_000614 OC(CN1CCC(O)(CC1)c2ccc(Cl)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L21 compound treatment 1520680.0 76500.0 0.37 1886610.0 140000.0 0.62 1639750.0 119780.625 0.624334749829671 1774730.0 -43897.09677419 -0.211654703677125 0.7031 0.7183 2075004 Maybridge2_000615 Fc1ccccc1NC(=O)OC2CN3CCC2CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L22 compound treatment 1248690.0 -196000.0 -0.96 1540000.0 -207000.0 -0.92 1299010.0 -220959.375 -1.15171060522639 1594560.0 -224067.09677419 -1.0803642713661 -2.0534 -0.9958 2075005 Maybridge2_000616 Clc1ccc(cc1)C(=O)C2CCN(CC2)C(=O)c3cnc4ccccc4n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L23 mock treatment 1595380.0 151000.0 0.74 1857190.0 110000.0 0.49 1686000.0 166030.625 0.865404473581924 1857230.0 38602.90322581 0.186128164360508 1.14 0.9099 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 L24 mock treatment 1229720.0 -214000.0 -1.05 1789990.0 43000.0 0.19 1403570.0 -116399.375 -0.606710598403999 1862430.0 43802.90322581 0.211200539073183 -0.6272 -0.5036 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M01 compound treatment 1622890.0 179000.0 0.87 1688810.0 -58200.0 -0.26 1769380.0 249410.625 1.30000757772166 1599060.0 -219567.09677419 -1.05866702401859 0.4289 0.2247 2075006 Maybridge2_000617 O=C(OCC1CCCN2CCCCC12)/C=C/c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M02 compound treatment 1493480.0 49300.0 0.24 1481030.0 -266000.0 -1.18 1724390.0 204420.625 1.06550537509217 1632820.0 -185807.09677419 -0.895889452807072 -0.3843 -0.2088 1386650 Maybridge2_000618 Cc1c(CN2CCSCC2)c(=O)n(c3ccccc3)n1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M03 compound treatment 1638150.0 194000.0 0.95 1266360.0 -481000.0 -2.13 1711390.0 191420.625 0.997745236523972 1350740.0 -467887.09677419 -2.25596934875926 -1.2203 -0.3594 2075007 Maybridge2_000619 OC1(CCN(CC1)C(=O)c2cc(F)cc3COCOc23)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M04 compound treatment 1326400.0 -118000.0 -0.58 1088650.0 -658000.0 -2.92 1269480.0 -250489.375 -1.30563036614324 1096450.0 -722177.09677419 -3.48205668831429 -4.1418 -0.8696 2075008 Maybridge2_000620 CCOC(=O)c1sc(SC)c2C(=O)/C(=C/N(C)C)/CCc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M05 compound treatment 1529530.0 85300.0 0.42 1638130.0 -109000.0 -0.48 1654630.0 134660.625 0.701894046898504 1476500.0 -342127.09677419 -1.64960360955426 -0.5064 -0.2661 1333727 Maybridge2_000621 CCN(CC)c1ncnc2n(ncc12)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M06 compound treatment 1737940.0 294000.0 1.44 1499700.0 -247000.0 -1.1 1755920.0 235950.625 1.22984977271182 1471730.0 -346897.09677419 -1.67260269174262 -0.051 -0.0185 1395190 Maybridge2_000622 Clc1cc(Cl)cc(NC(=O)OC2CN(C2)C(c3ccccc3)c4ccccc4)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M07 compound treatment 1496520.0 52300.0 0.26 1570840.0 -176000.0 -0.78 1681530.0 161560.625 0.842105410551166 1426880.0 -391747.09677419 -1.88885192363944 -0.7859 -0.3532 2075009 Maybridge2_000623 O=c1[nH]cc(N2CCCCCC2)c(=O)[nH]1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M08 compound treatment 1541860.0 97700.0 0.48 1796560.0 49600.0 0.22 1772580.0 252610.625 1.31668699644614 1496440.0 -322187.09677419 -1.55346069575219 0.2305 0.1096 2075010 Maybridge2_000624 CN1CCN(CC1)c2cc(nc3ccc(F)cc23)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M09 compound treatment 1497500.0 53300.0 0.26 1680070.0 -66900.0 -0.3 1863860.0 343890.625 1.79246741556194 1552350.0 -266277.09677419 -1.28388445148572 0.2363 0.1055 2075011 Maybridge2_000625 Cc1cc(NC(=O)CN2CCCCC2)n(n1)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M10 compound treatment 1315870.0 -128000.0 -0.63 1347360.0 -400000.0 -1.77 1321470.0 -198499.375 -1.03464193505395 1230680.0 -587947.09677419 -2.83485190799076 -3.1349 -0.8817 1150533 Maybridge2_000626 Oc1ccc2ccccc2c1C(N3CCCCC3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M11 compound treatment 1816670.0 372000.0 1.82 1852330.0 105000.0 0.47 1859940.0 339970.625 1.77203512762445 1710720.0 -107907.09677419 -0.520285993169112 1.7708 0.6716 2075012 Maybridge2_000627 O=C(CN1CCOCC1)N2CCc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M12 compound treatment 1427140.0 -17100.0 -0.08 1852650.0 106000.0 0.47 1844180.0 324210.625 1.68988899040639 1833970.0 15342.90322581 0.0739775036265039 1.0745 0.6115 2075013 Maybridge2_000628 FC(F)(F)c1ccc(cc1)C2C3N4CCC(CC4)C3=NN2c5cc(Cl)ccc5Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M13 compound treatment 1521140.0 76900.0 0.38 1579110.0 -168000.0 -0.74 1696380.0 176410.625 0.919508338069457 1345920.0 -472707.09677419 -2.2792095114737 -0.8638 -0.3328 2075014 Maybridge2_000629 CCOC(=O)N1CCc2c(C#N)c(N)sc2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M14 compound treatment 1521950.0 77700.0 0.38 1869780.0 123000.0 0.54 1733310.0 213340.625 1.11199925478666 1634880.0 -183747.09677419 -0.885956935132435 0.5755 0.3667 2075015 Maybridge2_000630 Cc1cc(Br)ccc1NC(=O)CN2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M15 compound treatment 1321330.0 -123000.0 -0.6 1744810.0 -2170.0 -0.01 1406500.0 -113469.375 -0.591438505634397 1619110.0 -199517.09677419 -0.961993733059144 -1.0822 -0.8458 1194772 Maybridge2_000631 Fc1ccc(Cn2cnc3sc(cc3c2=O)c4ccccc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M16 compound treatment 1658720.0 215000.0 1.05 1829120.0 82100.0 0.36 1711010.0 191040.625 0.99576455555044 1805480.0 -13147.09677419 -0.0633901801358255 1.1732 0.7856 2075016 Maybridge2_000632 Cc1nc(C)nc(n1)N(Cc2ccccc2Cl)Cc3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M17 compound treatment 1498160.0 54000.0 0.26 1490120.0 -257000.0 -1.14 1517780.0 -2189.375 -0.0114117194905965 1227110.0 -591517.09677419 -2.85206505755311 -1.8693 -0.6064 2075017 Maybridge2_000633 CC(=O)c1sc2nsc(SCCN3CCCCC3)c2c1N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M18 compound treatment 1403520.0 -40700.0 -0.2 1788480.0 41500.0 0.18 1320670.0 -199299.375 -1.03881178973507 1625870.0 -192757.09677419 -0.929399645932666 -0.9916 -0.6983 2075018 Maybridge2_000634 COc1cc(c(cn1)C(=O)N(C)Cc2ccc(Cl)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M19 compound treatment 1179400.0 -265000.0 -1.3 1120560.0 -626000.0 -2.78 1406760.0 -113209.375 -0.590083302863033 1247330.0 -571297.09677419 -2.75457209280498 -3.7092 -0.891 1488100 Maybridge2_000635 CN1CCN(CC1)c2ncnc3sc(cc23)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M20 compound treatment 1568250.0 124000.0 0.61 1863110.0 116000.0 0.52 1445760.0 -74209.375 -0.38680288715843 1722930.0 -95697.09677419 -0.461414128699543 0.1369 0.1372 2075019 Maybridge2_000636 CN(Cc1c(C)cc(Cl)cc1Cl)C(=O)c2cnc(Oc3ccc(Cl)cc3)cc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M21 compound treatment 1428710.0 -15500.0 -0.08 1649410.0 -97600.0 -0.43 1695540.0 175570.625 0.915129990654281 1661920.0 -156707.09677419 -0.755580586626525 -0.1745 -0.1379 1372843 Maybridge2_000637 CN(C)CCN1C(=O)c2ccccc2Sc3ccccc3S1(=O)=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M22 compound treatment 1245570.0 -199000.0 -0.97 1296660.0 -450000.0 -2.0 1022790.0 -497179.375 -2.59145718025012 1198240.0 -620387.09677419 -2.99126495331368 -4.2759 -0.9422 2075020 Maybridge2_000638 CN(C)/C=C/C(=O)c1sc(nc1C)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M23 mock treatment 1626750.0 183000.0 0.89 1770210.0 23200.0 0.1 1671780.0 151810.625 0.791285306625015 1739040.0 -79587.09677419 -0.383737983195466 0.7019 0.5581 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 M24 mock treatment 1229550.0 -215000.0 -1.05 1563600.0 -183000.0 -0.81 1358180.0 -161789.375 -0.843297728374049 1764710.0 -53917.09677419 -0.259967241104242 -1.4835 -0.9302 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N01 compound treatment 1505990.0 61800.0 0.3 1639040.0 -108000.0 -0.48 1724550.0 204580.625 1.0663393460284 1414200.0 -404427.09677419 -1.94998994505419 -0.53 -0.2311 1578630 Maybridge2_000639 Clc1cccc(Cl)c1C(=O)N2CCN(Cc3ccccc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N02 compound treatment 840930.0 -603000.0 -2.95 860690.0 -886000.0 -3.93 863590.0 -656379.375 -3.42125826179301 842120.0 -976507.09677419 -4.70833689229019 -7.5061 -0.9853 2075021 Maybridge2_000640 O=C(NCc1cc2ccccc2s1)c3ccccc3N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N03 compound treatment 1560320.0 116000.0 0.57 1663570.0 -83400.0 -0.37 1784330.0 264360.625 1.37793173707509 1715550.0 -103077.09677419 -0.496997614349455 0.5396 0.3343 1607897 Maybridge2_000641 CC1C(O)CC(N(C)C1c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N04 compound treatment 1661230.0 217000.0 1.06 1609970.0 -137000.0 -0.61 1768440.0 248470.625 1.29510799847135 1434450.0 -384177.09677419 -1.85235233199041 -0.0514 -0.02 2075022 Maybridge2_000642 O=S(=O)(N1CCC(=CC1)c2ccccc2)c3ccc4ccccc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N05 compound treatment 1573360.0 129000.0 0.63 1630350.0 -117000.0 -0.52 1638370.0 118400.625 0.617141750504739 1761120.0 -57507.09677419 -0.277276822877031 0.2273 0.2144 2075023 Maybridge2_000643 Oc1cc(nc(n1)N2CCSCC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N06 compound treatment 1514940.0 70700.0 0.35 1487530.0 -259000.0 -1.15 1861530.0 341560.625 1.78032271380318 1432760.0 -385867.09677419 -1.86050085377203 -0.4423 -0.1557 2075024 Maybridge2_000644 O=C(N1CCC(=CC1)c2ccccc2)c3cc4ccccc4o3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N07 compound treatment 1598920.0 155000.0 0.76 1646560.0 -100000.0 -0.45 1659520.0 139550.625 0.72738228363685 1535520.0 -283107.09677419 -1.3650321565654 -0.163 -0.0916 2075025 Maybridge2_000645 CN(C)C(=O)Oc1cc(C)nc(n1)c2ccc(C)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N08 compound treatment 1510290.0 66100.0 0.32 1739150.0 -7830.0 -0.03 1811570.0 291600.625 1.51991528896723 1386100.0 -432527.09677419 -2.08547720071307 -0.1385 -0.0532 2075026 Maybridge2_000646 O=S(=O)(N1CCC(=CC1)c2ccccc2)c3ccc4OCCOc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N09 compound treatment 1483360.0 39200.0 0.19 1626170.0 -121000.0 -0.54 1807270.0 287300.625 1.49750232005621 1562480.0 -256147.09677419 -1.23504153690122 -0.0408 -0.0202 2075027 Maybridge2_000647 CC(C)(C)NC(=O)N1CCOCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N10 compound treatment 1607520.0 163000.0 0.8 1576660.0 -170000.0 -0.76 1734140.0 214170.625 1.11632547901832 1379770.0 -438857.09677419 -2.11599799531523 -0.4779 -0.1815 2075028 Maybridge2_000648 Clc1ccc(CS(=O)(=O)N2CCc3ccccc3C2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N11 compound treatment 1395480.0 -48700.0 -0.24 1773330.0 26400.0 0.12 1493240.0 -26729.375 -0.139322011833954 1689640.0 -128987.09677419 -0.62192554296588 -0.4414 -0.6393 2075029 Maybridge2_000649 CN(C)c1ccc(/C=C\2/N=C(OC2=O)c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N12 compound treatment 1338630.0 -106000.0 -0.52 1820060.0 73100.0 0.32 1621960.0 101990.625 0.531607606358263 1631220.0 -187407.09677419 -0.903604029641741 -0.2823 -0.2327 2075030 Maybridge2_000650 Fc1ccc(CN2CCCN(Cc3ccc(F)cc3)C2c4csnn4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N13 compound treatment 1127810.0 -316000.0 -1.55 1221150.0 -526000.0 -2.33 1221760.0 -298209.375 -1.55436219787205 1211440.0 -607187.09677419 -2.92761969442765 -4.1811 -0.9637 2075031 Maybridge2_000651 Cc1ccc(cc1)N2C(=O)C(C(C2=O)c3ccccc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N14 compound treatment 1626420.0 182000.0 0.89 1856920.0 110000.0 0.49 1798770.0 278800.625 1.45319761406931 1636370.0 -182257.09677419 -0.878772735455149 0.9768 0.4936 2075032 Maybridge2_000652 Cc1onc(c1CN2CCS(=O)(=O)CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N15 compound treatment 1630820.0 187000.0 0.91 1675520.0 -71500.0 -0.32 1674080.0 154110.625 0.803273638833235 1718300.0 -100327.09677419 -0.483738185414867 0.4579 0.34 1611256 Maybridge2_000653 O=C(N1CCOCC1)c2ccc3ncsc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N16 compound treatment 1563200.0 119000.0 0.58 1794470.0 47500.0 0.21 1782500.0 262530.625 1.36839319449203 1757020.0 -61607.09677419 -0.297045426015871 0.9321 0.6088 2075033 Maybridge2_000654 O=S1(=O)CCN(Cc2ccc3OCCCOc3c2)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N17 compound treatment 1764960.0 321000.0 1.57 1722780.0 -24200.0 -0.11 1800890.0 280920.625 1.46424772897428 1864320.0 45692.90322581 0.220313382959136 1.5734 0.7283 2075034 Maybridge2_000655 CCOc1ccc(NC(=O)C2CCN(CC2)C(=O)C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N18 compound treatment 1474530.0 30300.0 0.15 1751430.0 4450.0 0.02 1678760.0 158790.625 0.827667288717788 1479400.0 -339227.09677419 -1.63562093904142 -0.3199 -0.1739 2075035 Maybridge2_000656 CC1(C)CCc2cc(ccc2O1)S(=O)(=O)NCCN3CCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N19 compound treatment 1596590.0 152000.0 0.75 1736660.0 -10300.0 -0.05 1720910.0 200940.625 1.0473665072293 1505960.0 -312667.09677419 -1.50755896358591 0.1199 0.0605 2075036 Maybridge2_000657 Fc1ccc(cc1)S(=O)(=O)N2CCCC2c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N20 compound treatment 1541290.0 97100.0 0.48 1682880.0 -64100.0 -0.28 1464160.0 -55809.375 -0.290896229492669 1596160.0 -222467.09677419 -1.07264969453143 -0.5864 -0.4723 2075037 Maybridge2_000658 OC(CN1CCC(CC1)c2c[nH]c3ccccc23)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N21 compound treatment 1460110.0 15900.0 0.08 1858720.0 112000.0 0.5 1301680.0 -218289.375 -1.13779371522815 1813870.0 -4757.09677418997 -0.0229368678590286 -0.2937 -0.2361 2075038 Maybridge2_000659 Fc1ccc(NC(=O)OC2CN3CCC2CC3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N22 compound treatment 1176160.0 -268000.0 -1.31 1314880.0 -432000.0 -1.92 1262790.0 -257179.375 -1.3405007759141 1492430.0 -326197.09677419 -1.57279535394408 -3.0706 -0.9878 1730920 Maybridge2_000660 COc1ccc(CN2CCCN(Cc3ccc(OC)cc3)C2c4ccc(F)cc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N23 mock treatment 1796990.0 353000.0 1.73 1780100.0 33100.0 0.15 1742480.0 222510.625 1.159796214069 1809480.0 -9147.09677418997 -0.0441037380491524 1.4944 0.7166 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 N24 mock treatment 1376870.0 -67300.0 -0.33 1673920.0 -73100.0 -0.32 1377550.0 -142419.375 -0.742335121907429 1700290.0 -118337.09677419 -0.570575390910113 -0.9832 -0.9417 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O01 compound treatment 1513660.0 69500.0 0.34 1685670.0 -61300.0 -0.27 1654810.0 134840.625 0.702832264201756 1508590.0 -310037.09677419 -1.49487812791392 -0.362 -0.2119 2075039 Maybridge2_000661 O=C(OCC1CCCN2CCCCC12)c3cc4ccccc4oc3=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O02 compound treatment 1748870.0 305000.0 1.49 1844380.0 97400.0 0.43 1772910.0 252940.625 1.3184070615021 2064120.0 245492.90322581 1.18367116518846 2.2124 0.9393 2075040 Maybridge2_000662 CCN/C=C(\C#N)/S(=O)(=O)c1ccc(Br)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O03 compound treatment 1622240.0 178000.0 0.87 1733450.0 -13500.0 -0.06 1659770.0 139800.625 0.7286853632247 1805440.0 -13187.09677419 -0.0635830445566923 0.7382 0.648 2075041 Maybridge2_000663 Cc1onc(c1C(=O)N2CCNCC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O04 compound treatment 1464000.0 19800.0 0.1 1572400.0 -175000.0 -0.77 1533160.0 13190.625 0.0687537367539366 1295460.0 -523167.09677419 -2.52250797839708 -1.5656 -0.5927 2075042 Maybridge2_000664 CN(C)/C=C/C(=O)c1ccc(s1)c2cc(n(C)n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O05 compound treatment 1496480.0 52300.0 0.26 1673710.0 -73300.0 -0.32 1727910.0 207940.625 1.0838527356891 1463520.0 -355107.09677419 -1.71218811412551 -0.3487 -0.1686 2075043 Maybridge2_000665 CCN(CC)CC(=O)Nc1cc(C)nn1c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O06 compound treatment 1612650.0 168000.0 0.82 1870010.0 123000.0 0.55 1810630.0 290660.625 1.51501570971692 1578080.0 -240547.09677419 -1.15982441276319 0.8625 0.4014 1620788 Maybridge2_000666 Clc1ccc(SC2CN(C2)C(c3ccccc3)c4ccccc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O07 compound treatment 1668640.0 224000.0 1.1 1603210.0 -144000.0 -0.64 1662650.0 142680.625 0.743696840076733 1700820.0 -117807.09677419 -0.568019937333628 0.3182 0.2017 1257903 Maybridge2_000667 Cc1ccc(cc1)S(=O)(=O)N2CCCCC2c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O08 compound treatment 1472120.0 27900.0 0.14 1548920.0 -198000.0 -0.88 1597090.0 77120.625 0.401977248958943 1368860.0 -449767.09677419 -2.16860176610663 -1.2542 -0.5274 2075044 Maybridge2_000668 CCN(CC)C(=O)c1ccc(s1)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O09 compound treatment 1578100.0 134000.0 0.66 1571290.0 -176000.0 -0.78 1748000.0 228030.625 1.18856821136873 1629050.0 -189577.09677419 -0.914066924473761 0.0753 0.0415 2075045 Maybridge2_000669 Fc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)CN5CCCCC5 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O10 compound treatment 1702030.0 258000.0 1.26 1822130.0 75200.0 0.33 1728230.0 208260.625 1.08552067756155 1783100.0 -35527.09677419 -0.171297823610762 1.2546 0.7354 2075046 Maybridge2_000670 COc1cc2CCN3CC(=O)Nc4ccccc4C3c2cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O11 compound treatment 1556890.0 113000.0 0.55 1666030.0 -80900.0 -0.36 1570370.0 50400.625 0.262704102609533 1599450.0 -219177.09677419 -1.05678659591514 -0.3008 -0.2364 2075047 Maybridge2_000671 CN1CCN(CC1)c2nnc(c3ccccc3)c(n2)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O12 compound treatment 1738590.0 294000.0 1.44 1753130.0 6150.0 0.03 1786880.0 266910.625 1.39122314887116 1900980.0 82352.90322581 0.397073624683496 1.6281 0.7974 1311955 Maybridge2_000672 O=C1N(C2CCN(Cc3ccccc3)CC2)C(=O)c4ccccc14 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O13 compound treatment 1620420.0 176000.0 0.86 1644990.0 -102000.0 -0.45 1603490.0 83520.625 0.435336086407904 1431560.0 -387067.09677419 -1.86628678639803 -0.5105 -0.2375 2075048 Maybridge2_000673 Cc1sc(NC(=O)CN2CCOCC2)c(C#N)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O14 compound treatment 1647700.0 203000.0 1.0 1786970.0 40000.0 0.18 1740680.0 220710.625 1.15041404103648 1654080.0 -164547.09677419 -0.793382013116404 0.7651 0.4435 2075049 Maybridge2_000674 FC(F)(F)c1cc(NC(=O)CN2CCCC2)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O15 compound treatment 1704500.0 260000.0 1.27 1856810.0 110000.0 0.49 1658970.0 139000.625 0.72451550854358 1597920.0 -220707.09677419 -1.06416366001329 0.7106 0.3789 2075050 Maybridge2_000675 O=C(Cn1cnc2sc(cc2c1=O)c3ccccc3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O16 compound treatment 890820.0 -553000.0 -2.71 909390.0 -838000.0 -3.71 857480.0 -662489.375 -3.45310552692007 951070.0 -867557.09677419 -4.18302242595443 -7.0293 -0.9886 2075051 Maybridge2_000676 CN(C)C(=O)Oc1nc(cs1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O17 compound treatment 1350110.0 -94100.0 -0.46 1300860.0 -446000.0 -1.98 1347760.0 -172209.375 -0.897610085595637 1331780.0 -486847.09677419 -2.34738708425009 -2.8419 -0.8795 2075052 Maybridge2_000677 Nc1c(sc2nsc(SCCN3CCCCC3)c12)C(=O)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O18 compound treatment 1682770.0 239000.0 1.17 1928190.0 181000.0 0.8 1606280.0 86310.625 0.44987845460831 1589480.0 -229147.09677419 -1.10485805281618 0.658 0.3552 2075053 Maybridge2_000678 CCOc1cc(c(cn1)C(=O)N(C)Cc2ccc(Cl)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O19 compound treatment 1563520.0 119000.0 0.58 1461170.0 -286000.0 -1.27 1561880.0 41910.625 0.218451519806147 1645530.0 -173097.09677419 -0.834606783076668 -0.6499 -0.3961 1249246 Maybridge2_000679 C=CCn1cnc2sc(cc2c1=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O20 compound treatment 1569380.0 125000.0 0.61 1678490.0 -68500.0 -0.3 1586800.0 66830.625 0.348342493123037 1764600.0 -54027.09677419 -0.260497618261625 0.1983 0.2447 2075054 Maybridge2_000680 COc1cccc(OC)c1CN(C)C(=O)c2cnc(SC)cc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O21 compound treatment 1711390.0 267000.0 1.31 1849390.0 102000.0 0.45 1748200.0 228230.625 1.18961067503901 1861290.0 42662.90322581 0.205703903078482 1.5785 0.8594 1166834 Maybridge2_000681 C=CCN1Cc2ccc3ccccc3c2-c4c(C1)ccc5ccccc45 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O22 compound treatment 1287360.0 -157000.0 -0.77 1470770.0 -276000.0 -1.22 1284960.0 -235009.375 -1.22494367806356 1605680.0 -212947.09677419 -1.02674796236515 -2.1221 -0.9847 1560070 Maybridge2_000682 C(N1CCN(CC1)c2cccc3[nH]ccc23)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O23 mock treatment 1695160.0 251000.0 1.23 1711590.0 -35400.0 -0.16 1698740.0 178770.625 0.931809409378761 1725880.0 -92747.09677419 -0.447190377660621 0.7779 0.4823 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 O24 mock treatment 1566570.0 122000.0 0.6 1657970.0 -89000.0 -0.39 1406110.0 -113859.375 -0.593471309791443 1800800.0 -17827.09677419 -0.0859553173772331 -0.2377 -0.2543 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P01 compound treatment 1433690.0 -10500.0 -0.05 1411100.0 -336000.0 -1.49 1529780.0 9810.625 0.0511361007262044 1282080.0 -536547.09677419 -2.58702112717701 -2.0384 -0.6826 1561821 Maybridge2_000683 Cc1cc(c(C)cc1Cl)S(=O)(=O)N2CCN(Cc3ccccc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P02 compound treatment 1437120.0 -7090.0 -0.03 1658000.0 -89000.0 -0.39 1646080.0 126110.625 0.657328724994033 1464320.0 -354307.09677419 -1.70833082570818 -0.7401 -0.3952 2075055 Maybridge2_000684 O=C(NCc1cccs1)c2ccccc2N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P03 compound treatment 1494610.0 50400.0 0.25 1681440.0 -65500.0 -0.29 1668360.0 148390.625 0.773459177863227 1807100.0 -11527.09677419 -0.0555791710907229 0.3369 0.3899 2075056 Maybridge2_000685 Fc1cccc(NC(=O)CN2CCCCC2)c1C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P04 compound treatment 1521670.0 77500.0 0.38 1766000.0 19000.0 0.08 1550400.0 30430.625 0.158614105132074 1677890.0 -140737.09677419 -0.678579466595482 -0.0283 -0.0354 2075057 Maybridge2_000686 FC(F)(F)c1cccc(c1)S(=O)(=O)N2CCC(=CC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P05 compound treatment 1377710.0 -66500.0 -0.33 1849640.0 103000.0 0.46 1855470.0 335500.625 1.7487360645937 1864670.0 46042.90322581 0.22200094664172 1.0503 0.5679 2075058 Maybridge2_000687 CCN(CC)C(=O)Oc1cc(nc(n1)c2ccc(Cl)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P06 compound treatment 1380860.0 -63300.0 -0.31 1682080.0 -64900.0 -0.29 1777340.0 257370.625 1.34149763179881 1756080.0 -62547.09677419 -0.301577739906239 0.2211 0.1537 2075059 Maybridge2_000688 O=C(N1CCC(=CC1)c2ccccc2)c3ccc4occc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P07 compound treatment 1356370.0 -87800.0 -0.43 1176000.0 -571000.0 -2.53 1234460.0 -285509.375 -1.48816575480927 1479590.0 -339037.09677419 -1.6347048330423 -3.0424 -0.8978 2075060 Maybridge2_000689 CN(C)C(=O)Oc1nc(nc(C)c1CC(=C)C)c2ccc(C)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P08 compound treatment 1745830.0 302000.0 1.48 1734930.0 -12000.0 -0.05 1704660.0 184690.625 0.96266633401905 1609730.0 -208897.09677419 -1.00722043975239 0.689 0.3393 2075061 Maybridge2_000690 O=S(=O)(N1CCC(=CC1)c2ccccc2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P09 compound treatment 1723960.0 280000.0 1.37 1777790.0 30800.0 0.14 1851140.0 331170.625 1.72616672613213 1741410.0 -77217.09677419 -0.372310766259113 1.4297 0.6387 2075062 Maybridge2_000691 CC(=O)N1C(CSC1c2ccc(C)cc2)C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P10 compound treatment 1628580.0 184000.0 0.9 1565080.0 -182000.0 -0.81 1720890.0 200920.625 1.04726226086227 1644040.0 -174587.09677419 -0.841790982753954 0.1505 0.0832 2075063 Maybridge2_000692 FC(F)(F)C1=NCCN(C=C1)S(=O)(=O)Cc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P11 compound treatment 78680.0 -1370000.0 -6.68 83240.0 -1660000.0 -7.38 78820.0 -1441149.375 -7.51172933442125 83420.0 -1735207.09677419 -8.36649279507991 -14.9693 -0.9968 2071191 Maybridge2_000693 CN1C/C(=C\c2ccccc2Cl)/C(=O)\C(=C\c3ccccc3Cl)\C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P12 compound treatment 1705180.0 261000.0 1.28 1775550.0 28600.0 0.13 1769820.0 249850.625 1.30230099779628 1851680.0 33052.90322581 0.159368225965249 1.4327 0.7806 2075064 Maybridge2_000694 CC1(C)Cc2cccc(C(=O)NC3CCN(Cc4ccccc4)CC3)c2O1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P13 compound treatment 1546490.0 102000.0 0.5 1559800.0 -187000.0 -0.83 1410430.0 -109539.375 -0.570954094513395 1483630.0 -334997.09677419 -1.61522552653476 -1.2579 -0.639 2075065 Maybridge2_000695 Cc1ccc(cc1)N2C(=O)C(C(C2=O)c3ccccc3)N4CCSCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P14 compound treatment 1562360.0 118000.0 0.58 1889820.0 143000.0 0.63 1796090.0 276120.625 1.43922860088756 1838640.0 20012.90322581 0.0964944247626948 1.3737 0.8186 2075066 Maybridge2_000696 Cc1cc(CN2CCS(=O)(=O)CC2)c(o1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P15 compound treatment 1532980.0 88800.0 0.43 1605570.0 -141000.0 -0.63 1667200.0 147230.625 0.767412888575603 1680670.0 -137957.09677419 -0.665175389345244 -0.0452 -0.0356 2075067 Maybridge2_000697 Fc1ccc(cc1)C(=O)N2CCN=C(C=C2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P16 compound treatment 1639860.0 196000.0 0.96 1893120.0 146000.0 0.65 1761670.0 241700.625 1.25982060323237 2049970.0 231342.90322581 1.11544537630685 1.9904 0.9749 2075068 Maybridge2_000698 CN1CCN(CC1)c2ccc(CN3CCS(=O)(=O)CC3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P17 compound treatment 1506430.0 62200.0 0.3 1524600.0 -222000.0 -0.99 1520010.0 40.625 2.11750433025628E-4 1697080.0 -121547.09677419 -0.586052760684668 -0.6338 -0.534 2075069 Maybridge2_000699 Fc1ccc(cc1)C2CCCN2S(=O)(=O)c3ccc(s3)c4ccccn4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P18 compound treatment 1811390.0 367000.0 1.8 1785090.0 38100.0 0.17 1752970.0 233000.625 1.21447343357519 1941040.0 122412.90322581 0.590227342181527 1.8852 0.8364 2075070 Maybridge2_000700 Clc1ccc(cc1)S(=O)(=O)NCCN2CCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P19 compound treatment 1603560.0 159000.0 0.78 1528380.0 -219000.0 -0.97 1515310.0 -4659.375 -0.0242861458185547 1819440.0 812.903225810034 0.00391950274666375 -0.105 -0.0844 2075071 Maybridge2_000701 Clc1ccc(cc1)S(=O)(=O)N2CCCC2c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P20 compound treatment 1684000.0 240000.0 1.17 1613560.0 -133000.0 -0.59 1720000.0 200030.625 1.04262329752953 1763410.0 -55217.09677419 -0.26623533478241 0.6791 0.3998 2075072 Maybridge2_000702 Cc1cc(N2CCN(CC(O)C(F)(F)F)CC2)c3ccccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P21 compound treatment 1383450.0 -60800.0 -0.3 1283810.0 -463000.0 -2.05 1406480.0 -113489.375 -0.591542752001425 1597210.0 -221417.09677419 -1.06758700348368 -2.0052 -0.8328 2075073 Maybridge2_000703 Clc1ccccc1NC(=O)OC2CN3CCC2CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P22 compound treatment 507910.0 -936000.0 -4.58 433920.0 -1310000.0 -5.82 959130.0 -560839.375 -2.92327336650025 1179300.0 -639327.09677419 -3.08258625659407 -8.2053 -0.9607 1672764 Maybridge2_000704 COc1ccc(CN2CCCN(Cc3ccc(OC)cc3)C2c4cccc(C)n4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P23 mock treatment 1527090.0 82900.0 0.41 1680090.0 -66900.0 -0.3 1458310.0 -61659.375 -0.321388291848359 1652730.0 -165897.09677419 -0.799891187320656 -0.5062 -0.5073 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1304 P24 mock treatment 1354190.0 -90000.0 -0.44 1522330.0 -225000.0 -1.0 1432880.0 -87089.375 -0.453937547524463 1653060.0 -165567.09677419 -0.798300055848506 -1.3445 -0.9437 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A01 compound treatment 1091450.0 -494000.0 -2.42 1175080.0 -508000.0 -2.25 1347770.0 -378834.375 -1.97460536495368 1205390.0 -293421.875 -1.41476599978764 -4.0309 -0.9826 2125345 Peakdale2_000001 Cc1ccc(cc1)c2cnc(NCCC#N)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A02 compound treatment 1400590.0 -185000.0 -0.91 1356760.0 -327000.0 -1.45 1519790.0 -206814.375 -1.07798236214584 1431840.0 -66971.875 -0.322912297155853 -1.8774 -0.9178 2125346 Peakdale2_000002 Cn1cc(cn1)c2ccccc2NC(=O)Nc3ccc(F)cc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A03 compound treatment 1427580.0 -158000.0 -0.77 1248960.0 -434000.0 -1.93 1378600.0 -348004.375 -1.81390959018001 1489370.0 -9441.875 -0.0455250438442767 -2.2797 -0.8268 2125347 Peakdale2_000003 COCCNc1ncc(cn1)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A04 compound treatment 1443860.0 -142000.0 -0.69 1285890.0 -398000.0 -1.76 1553360.0 -173244.375 -0.903004835089337 1408000.0 -90811.875 -0.437859491992425 -1.8987 -0.8857 2125348 Peakdale2_000004 Fc1ccc(cc1)c2cnc(NCCC#N)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A05 compound treatment 1303310.0 -282000.0 -1.38 1355920.0 -327000.0 -1.45 1399270.0 -327334.375 -1.70617096985657 1241010.0 -257801.875 -1.24302023300581 -2.8914 -0.9933 2125349 Peakdale2_000005 COc1ccc(cc1)c2cnc(NCc3ccncc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A06 compound treatment 1295750.0 -290000.0 -1.42 1328340.0 -355000.0 -1.57 1370340.0 -356264.375 -1.85696333976258 1336200.0 -162611.875 -0.784051127448208 -2.817 -0.9632 2125350 Peakdale2_000006 Fc1ccc(cc1)c2cnc(nc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A07 compound treatment 1442650.0 -143000.0 -0.7 1441850.0 -242000.0 -1.07 1545990.0 -180614.375 -0.941419621339155 1343360.0 -155451.875 -0.749528396113063 -1.7309 -0.9855 2125351 Peakdale2_000007 COc1ccc(cc1)c2cnc(nc2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A08 compound treatment 1550500.0 -35100.0 -0.17 1582400.0 -101000.0 -0.45 1667600.0 -59004.375 -0.307549586625392 1539200.0 40388.125 0.194735808450454 -0.3663 -0.6082 2125352 Peakdale2_000008 Fc1ccc(cc1)c2cnc(NCc3ccco3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A09 compound treatment 1452520.0 -133000.0 -0.65 1435590.0 -248000.0 -1.1 1647840.0 -78764.375 -0.410544997249057 1375560.0 -123251.875 -0.594272537315344 -1.3775 -0.9387 2125353 Peakdale2_000009 Cc1ccc(cc1)c2cnc(NCC=C)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A10 compound treatment 1470950.0 -115000.0 -0.56 1593440.0 -90000.0 -0.4 1632330.0 -94274.375 -0.491388054879273 1420750.0 -78061.875 -0.376383957841155 -0.9139 -0.9872 2125354 Peakdale2_000010 Clc1ccc(CNc2ncc(cn2)c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A11 compound treatment 1470790.0 -115000.0 -0.56 1513410.0 -170000.0 -0.75 1629840.0 -96764.375 -0.504366727574259 1224320.0 -274491.875 -1.32349291261246 -1.5718 -0.9246 2125355 Peakdale2_000011 OC1CCN(CC1)c2ncc(cn2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A12 compound treatment 1481200.0 -104000.0 -0.51 1466560.0 -217000.0 -0.96 1455050.0 -271554.375 -1.41542785221548 1349340.0 -149471.875 -0.720695165193487 -1.8043 -0.9369 2125356 Peakdale2_000012 CCN(CC)c1cc(nc(C)n1)c2cncc(c2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A13 compound treatment 1307720.0 -278000.0 -1.36 1329930.0 -353000.0 -1.57 1360190.0 -366414.375 -1.90986837102929 1080610.0 -418201.875 -2.01640656068141 -3.4268 -0.9884 2125357 Peakdale2_000013 Cc1ccc(cc1)c2cnc(nc2)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A14 compound treatment 1412090.0 -174000.0 -0.85 1487170.0 -196000.0 -0.87 1488350.0 -238254.375 -1.24185765111386 1331630.0 -167181.875 -0.806085887532232 -1.8836 -0.9832 2125358 Peakdale2_000014 Cc1nc(cc(n1)c2cncc(c2)c3ccccc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A15 compound treatment 1607950.0 22300.0 0.11 1620410.0 -63000.0 -0.28 1696270.0 -30334.375 -0.158112419490752 1377360.0 -121451.875 -0.585593638376341 -0.4569 -0.6751 2125359 Peakdale2_000015 CC(Nc1ncc(cn1)c2ccc(Cl)cc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A16 compound treatment 1456370.0 -129000.0 -0.63 1445440.0 -238000.0 -1.06 1540360.0 -186244.375 -0.970764973657538 1350830.0 -147981.875 -0.713510965516201 -1.686 -0.9791 2125360 Peakdale2_000016 CN(Cc1ccccc1)c2cc(nc(C)n2)c3cncc(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A17 compound treatment 1303950.0 -282000.0 -1.38 1514240.0 -169000.0 -0.75 1540320.0 -186284.375 -0.970973466391594 1284800.0 -214011.875 -1.03188190826196 -2.0656 -0.977 2125361 Peakdale2_000017 C1CCC(CC1)Nc2ncc(cn2)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A18 compound treatment 1394460.0 -191000.0 -0.94 1445920.0 -237000.0 -1.05 1420410.0 -306194.375 -1.59598255990798 1074620.0 -424191.875 -2.0452880077062 -2.8149 -0.9535 2125362 Peakdale2_000018 CN1CCN(CC1)c2cc(nc(C)n2)c3cncc(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A19 compound treatment 1540580.0 -45000.0 -0.22 1605410.0 -78000.0 -0.35 1676050.0 -50554.375 -0.263505496556061 1487170.0 -11641.875 -0.056132586991947 -0.4429 -0.9027 2125363 Peakdale2_000019 Cc1ccccc1C(=O)Nc2ccccc2c3cnn(C)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A20 compound treatment 1374750.0 -211000.0 -1.03 1496080.0 -187000.0 -0.83 1630400.0 -96204.375 -0.501447829297475 1276280.0 -222531.875 -1.07296202990657 -1.7185 -0.9671 2125364 Peakdale2_000020 Cc1nc(NCc2ccccc2)cc(n1)c3cncc(c3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A21 compound treatment 1479000.0 -107000.0 -0.52 1598670.0 -84700.0 -0.38 1687320.0 -39284.375 -0.204762668735782 1316990.0 -181821.875 -0.876674265569456 -0.9894 -0.8944 2125365 Peakdale2_000021 Cn1cc(cn1)c2ccccc2NC(=O)Cc3cc(F)cc(F)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A22 compound treatment 1403960.0 -182000.0 -0.89 1462940.0 -220000.0 -0.98 1533780.0 -192824.375 -1.00506202840975 1229920.0 -268891.875 -1.29649189369111 -2.0841 -0.9894 2125366 Peakdale2_000022 CC(Nc1cc(nc(C)n1)c2cncc(c2)c3ccc(F)cc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A23 mock treatment 1595600.0 10000.0 0.05 1646320.0 -37100.0 -0.16 1718560.0 -8044.375 -0.041929843438044 1480750.0 -18061.875 -0.0870873265410574 -0.1223 -0.6209 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 A24 mock treatment 1605650.0 20000.0 0.1 1581600.0 -102000.0 -0.45 1607010.0 -119594.375 -0.623363955536723 1412690.0 -86121.875 -0.415246138645801 -0.696 -0.7909 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B01 compound treatment 1038420.0 -547000.0 -2.68 1036850.0 -647000.0 -2.87 1102560.0 -624044.375 -3.25271794790049 1019520.0 -479291.875 -2.31095874745012 -5.5543 -0.9926 2125367 Peakdale2_000023 Cc1nc(NC2CC2)cc(n1)c3cncc(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B02 compound treatment 1220380.0 -365000.0 -1.79 1168760.0 -515000.0 -2.28 1432440.0 -294164.375 -1.53327837014063 1383680.0 -115131.875 -0.555121059879398 -3.079 -0.9257 2125368 Peakdale2_000024 C1CN(CCO1)c2cc(nc(n2)c3ccccc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B03 compound treatment 1493550.0 -92100.0 -0.45 1416370.0 -267000.0 -1.18 1530080.0 -196524.375 -1.02434760630993 1503580.0 4768.125 0.0229900416686296 -1.318 -0.8089 2125369 Peakdale2_000025 Cc1ccc(cc1)c2cnn(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B04 compound treatment 1231090.0 -355000.0 -1.73 1141370.0 -542000.0 -2.4 1298660.0 -427944.375 -2.23058231919094 1281230.0 -217581.875 -1.04909505782431 -3.7091 -0.9621 2125370 Peakdale2_000026 CC(Nc1cc(nc(n1)c2ccccc2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B05 compound treatment 1667790.0 82200.0 0.4 1295620.0 -388000.0 -1.72 1717120.0 -9484.375 -0.0494355818640601 1511650.0 12838.125 0.0619004385784927 -0.6525 -0.3691 2125371 Peakdale2_000027 C(c1ccccc1)n2cc(cn2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B06 compound treatment 1033980.0 -552000.0 -2.7 1082850.0 -601000.0 -2.66 1302720.0 -423884.375 -2.20942030668425 1257340.0 -241471.875 -1.16428333318697 -4.3682 -0.962 2125372 Peakdale2_000028 Clc1ccc(CNc2cc(nc(n2)c3cccnc3)c4cccnc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B07 compound treatment 629760.0 -956000.0 -4.68 599890.0 -1080000.0 -4.81 680640.0 -1045964.375 -5.45189930672321 576750.0 -922061.875 -4.44582323812919 -9.6901 -0.997 2125373 Peakdale2_000029 O=C(N1CCCC1)c2ccc(nc2)c3cnn(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B08 compound treatment 838560.0 -747000.0 -3.66 688960.0 -994000.0 -4.41 946460.0 -780144.375 -4.06636084255404 1183040.0 -315771.875 -1.52252899494692 -6.8273 -0.9498 2125374 Peakdale2_000030 Clc1ccc(CNc2cc(nc(n2)c3ccncc3)c4cccnc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B09 compound treatment 1697200.0 112000.0 0.55 1395330.0 -288000.0 -1.28 1785150.0 58545.625 0.305158435581687 1480290.0 -18521.875 -0.0893052673810248 -0.2578 -0.1809 2123860 Peakdale2_000031 CCCN1CCC(CC1)N(C2CC2)C(=O)c3ccco3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B10 compound treatment 1486670.0 -98900.0 -0.48 1161190.0 -522000.0 -2.32 1572320.0 -154284.375 -0.804179279146791 1390080.0 -108731.875 -0.524262752540721 -2.0642 -0.8085 2125375 Peakdale2_000032 Cc1nc(NCC=C)cc(n1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B11 compound treatment 1676370.0 90800.0 0.44 1375430.0 -308000.0 -1.37 1661760.0 -64844.375 -0.337989525797568 1459630.0 -39181.875 -0.188919740758692 -0.7243 -0.4869 2125376 Peakdale2_000033 Cc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B12 compound treatment 1341190.0 -244000.0 -1.2 1431530.0 -252000.0 -1.12 1542800.0 -183804.375 -0.958046916880121 1452190.0 -46621.875 -0.224792523039904 -1.7479 -0.9153 2125377 Peakdale2_000034 Cc1nc(NC2CCCCC2)cc(n1)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B13 compound treatment 1063360.0 -522000.0 -2.56 1278480.0 -405000.0 -1.8 1255840.0 -470764.375 -2.45377379099789 1168500.0 -330311.875 -1.59263521193198 -4.1988 -0.9812 2125378 Peakdale2_000035 Brc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B14 compound treatment 156000.0 -1430000.0 -7.0 311280.0 -1370000.0 -6.09 763880.0 -962724.375 -5.01802592715267 757770.0 -741041.875 -3.57301530149679 -10.8358 -0.9734 2125379 Peakdale2_000036 CN1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B15 compound treatment 1481600.0 -104000.0 -0.51 1325840.0 -358000.0 -1.59 1448100.0 -278504.375 -1.45165346475771 936080.0 -562731.875 -2.71327392937812 -3.1298 -0.8945 2125380 Peakdale2_000037 OC1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B16 compound treatment 1144360.0 -441000.0 -2.16 1299270.0 -384000.0 -1.7 1443110.0 -283494.375 -1.4776629333312 1225670.0 -273141.875 -1.3169837384082 -3.3287 -0.9823 2125381 Peakdale2_000038 C=CCNc1cc(nc(n1)c2cccnc2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B17 compound treatment 311290.0 -1270000.0 -6.24 888710.0 -795000.0 -3.52 1178930.0 -547674.375 -2.85465319540407 1022140.0 -476671.875 -2.29832612788335 -7.4565 -0.9267 2125382 Peakdale2_000039 CN1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B18 compound treatment 1663310.0 77700.0 0.38 1691000.0 7600.0 0.03 1806180.0 79575.625 0.414773490511631 1339760.0 -159051.875 -0.766886193991069 0.0309 0.0325 2124445 Peakdale2_000040 FC(F)(F)c1cccc(c1)S(=O)(=O)N2CCN(Cc3cccc(Cl)n3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B19 compound treatment 1596250.0 10600.0 0.05 1736200.0 52800.0 0.23 1700390.0 -26214.375 -0.136637667882983 1407770.0 -91041.875 -0.438968462412409 -0.1447 -0.279 2124194 Peakdale2_000041 Cc1ccc(cc1)S(=O)(=O)N(C2CC2)C3CCN(Cc4ccccc4)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B20 compound treatment 1518780.0 -66800.0 -0.33 1701710.0 18300.0 0.08 1816270.0 89665.625 0.467365782677257 1391690.0 -107121.875 -0.516499959600835 -0.1475 -0.1906 2125383 Peakdale2_000042 Cc1nc(cc(n1)c2ccc(F)cc2)N3CCC4(CC3)OCCO4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B21 compound treatment 1214150.0 -371000.0 -1.82 1532640.0 -151000.0 -0.67 1685050.0 -41554.375 -0.216594631393461 1280250.0 -218561.875 -1.05382023613555 -1.8783 -0.8478 2125384 Peakdale2_000043 Cc1nc(NCc2ccccc2)cc(n1)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B22 compound treatment 1539420.0 -46200.0 -0.23 1769480.0 86100.0 0.38 1820290.0 93685.625 0.488319302449886 1378450.0 -120361.875 -0.580338082907723 0.0319 0.0363 2125385 Peakdale2_000044 CN1CCN(CC1)c2cc(nc(C)n2)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B23 mock treatment 1636840.0 51200.0 0.25 1720960.0 37600.0 0.17 1844800.0 118195.625 0.616073225242702 1346030.0 -152781.875 -0.736654696020209 0.1483 0.1474 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 B24 mock treatment 1624510.0 38900.0 0.19 1728400.0 45000.0 0.2 1707490.0 -19114.375 -0.0996302075880428 1578080.0 79268.125 0.382200025532917 0.3363 0.698 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C01 compound treatment 1454040.0 -132000.0 -0.64 1201300.0 -482000.0 -2.14 1532970.0 -193634.375 -1.00928400627438 1535230.0 36418.125 0.175594014679431 -1.8077 -0.7359 2125386 Peakdale2_000045 Clc1ccc(cc1)c2cnc(NCCC#N)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C02 compound treatment 1608870.0 23300.0 0.11 1296960.0 -386000.0 -1.71 1611290.0 -115314.375 -0.60105523299273 1529520.0 30708.125 0.148062618600705 -1.0265 -0.5622 2125387 Peakdale2_000046 CCNC(=O)Nc1ccccc1c2cnn(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C03 compound treatment 1333150.0 -252000.0 -1.24 1204810.0 -479000.0 -2.12 1239740.0 -486864.375 -2.53769211645543 1238040.0 -260771.875 -1.25734041625517 -3.5764 -0.9541 2125388 Peakdale2_000047 COCCNc1ncc(cn1)c2cc3ccccc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C04 compound treatment 1233980.0 -352000.0 -1.72 1107520.0 -576000.0 -2.55 1379680.0 -346924.375 -1.8082802863605 1270670.0 -228141.875 -1.10001126493313 -3.5914 -0.9611 2125389 Peakdale2_000048 Cc1cnc(CNc2ncc(cn2)c3ccc(F)cc3)cn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C05 compound treatment 1496750.0 -88900.0 -0.43 1239950.0 -443000.0 -1.97 1592760.0 -133844.375 -0.697639492044174 1402000.0 -96811.875 -0.466789155122435 -1.7829 -0.8171 2125390 Peakdale2_000049 C(Nc1ncc(cn1)c2cccs2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C06 compound treatment 1422080.0 -164000.0 -0.8 1140760.0 -543000.0 -2.41 1193770.0 -532834.375 -2.77730239106929 1300830.0 -197981.875 -0.954591491599615 -3.4693 -0.8941 2125391 Peakdale2_000050 Fc1ccc(cc1)c2cnc(nc2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C07 compound treatment 1587450.0 1850.0 0.01 1390480.0 -293000.0 -1.3 1626350.0 -100254.375 -0.522557718620645 1612900.0 114088.125 0.550088503897407 -0.6312 -0.4196 2125392 Peakdale2_000051 Clc1ccc(cc1)c2cnc(nc2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C08 compound treatment 1594130.0 8530.0 0.04 1358410.0 -325000.0 -1.44 1385820.0 -340784.375 -1.77627665168291 1395480.0 -103331.875 -0.498226055723712 -1.837 -0.7846 2125393 Peakdale2_000052 C(Nc1ncc(cn1)c2ccccc2)c3ccco3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C09 compound treatment 1439970.0 -146000.0 -0.71 1087530.0 -596000.0 -2.64 1407540.0 -319064.375 -1.6630650970905 1422850.0 -75961.875 -0.366258575745651 -2.6923 -0.8352 2125394 Peakdale2_000053 COc1ccc(cc1)c2cnc(NCC=C)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C10 compound treatment 1730530.0 145000.0 0.71 1537570.0 -146000.0 -0.65 1755280.0 28675.625 0.149466486425367 1235800.0 -263011.875 -1.2681408238237 -0.5281 -0.3306 2125395 Peakdale2_000054 Fc1ccc(cc1)c2cnc(NC3CCCCC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C11 compound treatment 1712060.0 126000.0 0.62 1667880.0 -15500.0 -0.07 1761060.0 34455.625 0.179593686496459 1214020.0 -284791.875 -1.37315550098564 -0.3218 -0.2119 2125396 Peakdale2_000055 Cc1ccc(cc1)c2cnc(NCc3ccccc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C12 compound treatment 1489400.0 -96200.0 -0.47 1365050.0 -318000.0 -1.41 1509390.0 -217214.375 -1.1321904730004 1407650.0 -91161.875 -0.439547055675009 -1.7272 -0.8991 2125397 Peakdale2_000056 CCN(CC)c1cc(nc(C)n1)c2cncc(c2)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C13 compound treatment 1639860.0 54300.0 0.27 1546620.0 -137000.0 -0.61 1581310.0 -145294.375 -0.757320537167704 1464390.0 -34421.875 -0.165968874675551 -0.6322 -0.6201 2125398 Peakdale2_000057 COc1ccc(cc1)c2cnc(nc2)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C14 compound treatment 1484660.0 -101000.0 -0.49 1482570.0 -201000.0 -0.89 1473490.0 -253114.375 -1.31931270181566 1472000.0 -26811.875 -0.129276418605655 -1.4166 -0.8474 2125399 Peakdale2_000058 Cc1nc(cc(n1)c2cncc(c2)c3ccc(F)cc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C15 compound treatment 1437640.0 -148000.0 -0.72 1652260.0 -31100.0 -0.14 1606920.0 -119684.375 -0.623833064188349 1218940.0 -279871.875 -1.34943317721903 -1.4177 -0.8544 2125400 Peakdale2_000059 CC(Nc1ncc(cn1)c2cccs2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C16 compound treatment 1413290.0 -172000.0 -0.84 1530960.0 -152000.0 -0.68 1520820.0 -205784.375 -1.0726136742439 1283160.0 -215651.875 -1.03978934951749 -1.8158 -0.9848 2125401 Peakdale2_000060 CN(Cc1ccccc1)c2cc(nc(C)n2)c3cncc(c3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C17 compound treatment 1375650.0 -210000.0 -1.03 1341090.0 -342000.0 -1.52 1397780.0 -328824.375 -1.71393732420016 1053690.0 -445121.875 -2.14620431592472 -3.2028 -0.9699 2125402 Peakdale2_000061 Cc1ccc(cc1)c2cnc(NC3CC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C18 compound treatment 1476130.0 -109000.0 -0.54 1492600.0 -191000.0 -0.85 1410670.0 -315934.375 -1.64675054065061 1253340.0 -245471.875 -1.18356977527364 -2.1061 -0.9312 2125403 Peakdale2_000062 CN1CCN(CC1)c2cc(nc(C)n2)c3cncc(c3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C19 compound treatment 1508840.0 -76800.0 -0.38 1645320.0 -38100.0 -0.17 1661350.0 -65254.375 -0.340126576321642 1220930.0 -277881.875 -1.33983817228091 -1.1122 -0.7711 2125404 Peakdale2_000063 Cn1cc(cn1)c2ccccc2NC(=O)c3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C20 compound treatment 1471280.0 -114000.0 -0.56 1452820.0 -231000.0 -1.02 1504400.0 -222204.375 -1.15819994157388 1354880.0 -143931.875 -0.693983442903444 -1.7171 -0.9626 2125405 Peakdale2_000064 Cc1ccc(cc1)c2cncc(c2)c3cc(NCc4ccco4)nc(C)n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C21 compound treatment 1463580.0 -122000.0 -0.6 1722430.0 39000.0 0.17 1816970.0 90365.625 0.471014405523238 1294030.0 -204781.875 -0.98737844314696 -0.4702 -0.3737 2125406 Peakdale2_000065 CC(C)CC(=O)Nc1ccccc1c2cnn(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C22 compound treatment 1342430.0 -243000.0 -1.19 1516870.0 -167000.0 -0.74 1545440.0 -181164.375 -0.944286396432425 1118080.0 -380731.875 -1.83574081443449 -2.3543 -0.9437 2125407 Peakdale2_000066 Cc1ccc(cc1)c2cncc(c2)c3cc(NCc4ccc(Cl)cc4)nc(C)n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C23 mock treatment 1517920.0 -67700.0 -0.33 1763790.0 80400.0 0.36 1704000.0 -22604.375 -0.117821198634429 1368320.0 -130491.875 -0.629180997492223 -0.3609 -0.4488 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 C24 mock treatment 1589370.0 3770.0 0.02 1747740.0 64300.0 0.29 1786320.0 59715.625 0.311256848052825 1297870.0 -200941.875 -0.968863458743754 -0.1769 -0.1674 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D01 compound treatment 1162520.0 -423000.0 -2.07 1166730.0 -517000.0 -2.29 1246650.0 -479954.375 -2.50167499664725 1244050.0 -254761.875 -1.22836253701994 -4.0458 -0.9726 2125408 Peakdale2_000067 Cc1nc(NC2CC2)cc(n1)c3cncc(c3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D02 compound treatment 1287150.0 -298000.0 -1.46 1355360.0 -328000.0 -1.45 1351860.0 -374744.375 -1.95328698289645 1407450.0 -91361.875 -0.440511377779343 -2.6545 -0.9237 2125409 Peakdale2_000068 C1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D03 compound treatment 1595230.0 9630.0 0.05 1270480.0 -413000.0 -1.83 1490620.0 -235984.375 -1.23002568845618 1551620.0 52808.125 0.254620211129574 -1.3798 -0.6212 2125410 Peakdale2_000069 Cc1ccc(cc1)c2cnn(CCO)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D04 compound treatment 1112960.0 -473000.0 -2.31 999010.0 -684000.0 -3.04 1154440.0 -572164.375 -2.98230287182986 1349250.0 -149561.875 -0.721129110140437 -4.5257 -0.9243 2125411 Peakdale2_000070 Clc1ccc(CNc2cc(nc(n2)c3ccccc3)c4cccnc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D05 compound treatment 1551290.0 -34300.0 -0.17 1369280.0 -314000.0 -1.39 1566600.0 -160004.375 -0.8339937401168 1539870.0 41058.125 0.197966287499972 -1.0985 -0.6681 2123519 Peakdale2_000071 COc1cccc(OC)c1CN2CCC(CC2)N(C)C(=O)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D06 compound treatment 1082570.0 -503000.0 -2.46 1013010.0 -670000.0 -2.97 1101230.0 -625374.375 -3.25965033130785 1152270.0 -346541.875 -1.67088995069866 -5.1826 -0.9739 2125412 Peakdale2_000072 C1CC1Nc2cc(nc(n2)c3cccnc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D07 compound treatment 1642170.0 56600.0 0.28 1209600.0 -474000.0 -2.1 1602800.0 -123804.375 -0.645307815796117 1492370.0 -6441.875 -0.0310602122792719 -1.2504 -0.5643 2125413 Peakdale2_000073 O=C(NCc1ccccc1)c2ccc(nc2)c3cnn(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D08 compound treatment 1180100.0 -406000.0 -1.98 1030920.0 -652000.0 -2.89 1283450.0 -443154.375 -2.30986168131573 1199460.0 -299351.875 -1.44335815018113 -4.3156 -0.9716 2125414 Peakdale2_000074 C1CC1Nc2cc(nc(n2)c3ccncc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D09 compound treatment 1689650.0 104000.0 0.51 1403530.0 -280000.0 -1.24 1717540.0 -9064.375 -0.0472464081564721 1446590.0 -52221.875 -0.251793541961246 -0.5155 -0.3775 2125415 Peakdale2_000075 Clc1ccc(CNC(=O)c2ccc(nc2)c3cnn(c3)c4ccc(Cl)cc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D10 compound treatment 1597020.0 11400.0 0.06 1322180.0 -361000.0 -1.6 1678850.0 -47754.375 -0.248911005172141 1483120.0 -15691.875 -0.0756601096047035 -0.9353 -0.576 2125416 Peakdale2_000076 CN1CCN(CC1)c2cc(nc(C)n2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D11 compound treatment 1583520.0 -2080.0 -0.01 1359870.0 -324000.0 -1.43 1597640.0 -128964.375 -0.672203378489341 1554260.0 55448.125 0.267349262906778 -0.9249 -0.5756 2125417 Peakdale2_000077 Cc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D12 compound treatment 1478850.0 -107000.0 -0.52 1436960.0 -246000.0 -1.09 1667970.0 -58634.375 -0.305621028835374 1304640.0 -194171.875 -0.936221155512059 -1.4286 -0.9151 2125418 Peakdale2_000078 Cc1nc(NC2CC2)cc(n1)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D13 compound treatment 1526530.0 -59100.0 -0.29 1480830.0 -203000.0 -0.9 1555480.0 -171124.375 -0.891954720184368 1515780.0 16968.125 0.0818136900329827 -0.9988 -0.7676 2125419 Peakdale2_000079 CC(C)c1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D14 compound treatment 699840.0 -886000.0 -4.33 556800.0 -1130000.0 -5.0 1125800.0 -600804.375 -3.13158366941395 1377140.0 -121671.875 -0.586654392691109 -6.5244 -0.8887 2125420 Peakdale2_000080 C(Nc1cc(nc(n1)c2ccccc2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D15 compound treatment 1721390.0 136000.0 0.66 1697070.0 13700.0 0.06 1771680.0 45075.625 0.234948507388328 1327080.0 -171731.875 -0.828024215405823 0.066 0.0606 2125421 Peakdale2_000081 C(Nc1cc(nc(n1)c2cccnc2)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D16 compound treatment 1590250.0 4650.0 0.02 1630040.0 -53400.0 -0.24 1630530.0 -96074.375 -0.500770227911793 1516240.0 17428.125 0.0840316308729501 -0.3153 -0.5624 2125422 Peakdale2_000082 C(Nc1cc(nc(n1)c2cccnc2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D17 compound treatment 668000.0 -918000.0 -4.49 920180.0 -763000.0 -3.38 1204120.0 -522484.375 -2.7233548961323 1036070.0 -462741.875 -2.23116109331651 -6.4147 -0.9669 2125423 Peakdale2_000083 OC1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D18 compound treatment 657300.0 -928000.0 -4.54 804270.0 -879000.0 -3.9 823140.0 -903464.375 -4.7091439416487 764890.0 -733921.875 -3.53868543458252 -8.3446 -0.9936 2125424 Peakdale2_000084 CC(Nc1cc(nc(n1)c2ccncc2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D19 compound treatment 1389930.0 -196000.0 -0.96 1690140.0 6740.0 0.03 1777860.0 51255.625 0.267160634799981 1599580.0 100768.125 0.485864651748785 -0.0873 -0.0789 2125425 Peakdale2_000085 Cc1nc(cc(n1)c2cccnc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D20 compound treatment 1310640.0 -275000.0 -1.35 1455150.0 -228000.0 -1.01 1436480.0 -290124.375 -1.51222060400098 1114840.0 -383971.875 -1.8513628325247 -2.8607 -0.9784 2125426 Peakdale2_000086 CCN(CC)c1cc(nc(C)n1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D21 compound treatment 1352260.0 -233000.0 -1.14 1689070.0 5670.0 0.03 1666560.0 -60044.375 -0.312970397710848 1324570.0 -174241.875 -0.84012645781521 -1.1349 -0.7816 2125427 Peakdale2_000087 Cc1nc(NCc2ccco2)cc(n1)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D22 compound treatment 1396090.0 -190000.0 -0.93 1606660.0 -76700.0 -0.34 1519360.0 -207244.375 -1.08022365903694 1245300.0 -253511.875 -1.22233552386786 -1.7851 -0.9361 2125428 Peakdale2_000088 Cc1nc(cc(n1)c2ccc(F)cc2)N3CCC(O)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D23 mock treatment 1636990.0 51400.0 0.25 1697850.0 14400.0 0.06 1805690.0 79085.625 0.412219454519445 1330900.0 -167911.875 -0.80960566321305 -0.0409 -0.0433 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 D24 mock treatment 1607870.0 22300.0 0.11 1727840.0 44400.0 0.2 1802890.0 76285.625 0.397624963135524 1561470.0 62658.125 0.302113074768007 0.5029 0.918 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E01 compound treatment 1417340.0 -168000.0 -0.82 1399470.0 -284000.0 -1.26 1447310.0 -279294.375 -1.45577119625531 1415310.0 -83501.875 -0.40261351907903 -1.9705 -0.9243 2125429 Peakdale2_000089 Cc1ccc(cc1)c2cnc(NCc3cnc(C)cn3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E02 compound treatment 1367650.0 -218000.0 -1.07 1392000.0 -291000.0 -1.29 1361440.0 -365164.375 -1.90335297309004 1294400.0 -204411.875 -0.985594447253943 -2.6239 -0.9645 2125430 Peakdale2_000090 Cc1nc(cc(n1)c2cncc(Br)c2)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E03 compound treatment 1562680.0 -22900.0 -0.11 1485960.0 -197000.0 -0.88 1584270.0 -142334.375 -0.74189207484756 1566310.0 67498.125 0.325449669692881 -0.7021 -0.586 2125431 Peakdale2_000091 Cc1ccc(cc1)c2cnc(nc2)N3CCC4(CC3)OCCO4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E04 compound treatment 1044570.0 -541000.0 -2.65 948080.0 -735000.0 -3.26 1057650.0 -668954.375 -3.48680316506187 988320.0 -510491.875 -2.46139299572617 -5.9283 -0.99 2125432 Peakdale2_000092 Cc1cnc(CNc2ncc(cn2)c3ccccc3)cn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E05 compound treatment 1466280.0 -119000.0 -0.58 1120650.0 -563000.0 -2.5 1418630.0 -307974.375 -1.60526048657347 1399860.0 -98951.875 -0.477107401638805 -2.581 -0.843 2125433 Peakdale2_000093 Cc1ccc(cc1)c2cnc(nc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E06 compound treatment 1589190.0 3590.0 0.02 1486600.0 -197000.0 -0.87 1609650.0 -116954.375 -0.609603435089026 1522460.0 23648.125 0.114022048317727 -0.6754 -0.6307 2125434 Peakdale2_000094 CN(Cc1ccccc1)c2ncc(cn2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E07 compound treatment 1544390.0 -41200.0 -0.2 1657180.0 -26200.0 -0.12 1656830.0 -69774.375 -0.363686255269971 1324960.0 -173851.875 -0.83824602971176 -0.76 -0.8059 2125435 Peakdale2_000095 C1CCN(CC1)c2ncc(cn2)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E08 compound treatment 1161140.0 -424000.0 -2.08 1199370.0 -484000.0 -2.15 1477730.0 -248874.375 -1.29721247200572 1255840.0 -242971.875 -1.17151574896947 -3.3462 -0.9669 2125436 Peakdale2_000096 Fc1ccc(cc1)c2cnc(nc2)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E09 compound treatment 1562970.0 -22600.0 -0.11 1464130.0 -219000.0 -0.97 1691160.0 -35444.375 -0.184747366266406 1421520.0 -77291.875 -0.37267131773947 -0.8203 -0.7714 2125437 Peakdale2_000097 Clc1ccc(cc1)c2cnc(NCC=C)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E10 compound treatment 1297250.0 -288000.0 -1.41 1362400.0 -321000.0 -1.42 1617970.0 -108634.375 -0.566236946405378 1548110.0 49298.125 0.237696358198518 -1.5816 -0.7544 2125438 Peakdale2_000098 C1CCC(CC1)Nc2ncc(cn2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E11 compound treatment 1703850.0 118000.0 0.58 1565390.0 -118000.0 -0.52 1758650.0 32045.625 0.167031999269585 1304380.0 -194431.875 -0.937474774247693 -0.3576 -0.2905 2125439 Peakdale2_000099 COc1ccc(cc1)c2cnc(NCc3ccccc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E12 compound treatment 1432080.0 -154000.0 -0.75 1266260.0 -417000.0 -1.85 1453120.0 -273484.375 -1.42548762663368 1141920.0 -356891.875 -1.72079361959792 -2.8737 -0.959 2125440 Peakdale2_000100 Cc1ccc(cc1)c2cncc(c2)c3cc(NCc4ccncc4)nc(C)n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E13 compound treatment 1759840.0 174000.0 0.85 1737120.0 53700.0 0.24 1714030.0 -12574.375 -0.0655416455698863 1569730.0 70918.125 0.341939577676987 0.6836 0.7186 2122582 Peakdale2_000101 COc1cccc(CCN2CCCC2)c1NC(=O)c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E14 compound treatment 1491780.0 -93800.0 -0.46 1602630.0 -80800.0 -0.36 1689120.0 -37484.375 -0.195380495703262 1534930.0 36118.125 0.17414753152293 -0.4193 -0.6567 2125441 Peakdale2_000102 Cc1ccc(cc1)c2cncc(c2)c3cc(nc(C)n3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E15 compound treatment 1679490.0 93900.0 0.46 1708010.0 24600.0 0.11 1752420.0 25815.625 0.134559255940363 1347470.0 -151341.875 -0.729711576869007 -0.0133 -0.0151 2125442 Peakdale2_000103 COc1ccc(cc1)c2cnc(NCc3ccc(Cl)cc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E16 compound treatment 1440170.0 -145000.0 -0.71 1512440.0 -171000.0 -0.76 1320200.0 -406404.375 -2.11830898190178 1125620.0 -373191.875 -1.79938587110112 -2.6938 -0.9077 2125443 Peakdale2_000104 Cc1ccc(cc1)c2cncc(c2)c3cc(NCC=C)nc(C)n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E17 compound treatment 910100.0 -676000.0 -3.31 1089340.0 -594000.0 -2.63 1009920.0 -716684.375 -3.73558711997419 871700.0 -627111.875 -3.02368921476313 -6.3497 -0.9921 2125444 Peakdale2_000105 COc1ccc(cc1)c2cnc(NC3CC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E18 compound treatment 1574490.0 -11100.0 -0.05 1450610.0 -233000.0 -1.03 1567100.0 -159504.375 -0.8313875809411 1387120.0 -111691.875 -0.538534719684859 -1.2283 -0.8579 2125445 Peakdale2_000106 Cc1nc(cc(n1)c2cncc(c2)c3cccs3)N4CCC(O)CC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E19 compound treatment 1697280.0 112000.0 0.55 1728260.0 44900.0 0.2 1795540.0 68935.625 0.359314423252734 1713480.0 214668.125 1.0350460901668 1.0699 0.8625 2125446 Peakdale2_000107 Cn1cc(cn1)c2ccccc2NC(=O)c3ccco3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E20 compound treatment 921200.0 -664000.0 -3.25 897120.0 -786000.0 -3.49 898880.0 -827724.375 -4.31436294971366 669800.0 -829011.875 -3.99717237908795 -7.5249 -0.9939 2125447 Peakdale2_000108 Cc1nc(NCc2ccco2)cc(n1)c3cncc(c3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E21 compound treatment 1454970.0 -131000.0 -0.64 1681620.0 -1780.0 -0.01 1773350.0 46745.625 0.243653079035166 1263170.0 -235641.875 -1.13617334384564 -0.7698 -0.5805 2125448 Peakdale2_000109 Cn1cc(cn1)c2ccccc2NC(=O)Cc3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E22 compound treatment 1160740.0 -425000.0 -2.08 1411590.0 -272000.0 -1.21 1294140.0 -432464.375 -2.25414199813926 1347760.0 -151051.875 -0.728313309817723 -3.1335 -0.9286 2125449 Peakdale2_000110 Cc1nc(NCc2ccc(Cl)cc2)cc(n1)c3cncc(c3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E23 mock treatment 1513280.0 -72300.0 -0.35 1607730.0 -75700.0 -0.34 1742820.0 16215.625 0.0845209997669219 1330450.0 -168361.875 -0.811775387947801 -0.7084 -0.745 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 E24 mock treatment 1501140.0 -84500.0 -0.41 1705540.0 22100.0 0.1 1819740.0 93135.625 0.485452527356616 1690110.0 191298.125 0.922365052275415 0.5463 0.4854 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F01 compound treatment 1565060.0 -20500.0 -0.1 1548100.0 -135000.0 -0.6 1634400.0 -92204.375 -0.480598555891874 1594560.0 95748.125 0.46166016693001 -0.3598 -0.3987 2125450 Peakdale2_000111 Cc1cc(C)cc(NC(=O)N2CCNC(=O)CC2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F02 compound treatment 1461540.0 -124000.0 -0.61 1211010.0 -472000.0 -2.09 1414980.0 -311624.375 -1.62428544855608 1452760.0 -46051.875 -0.222044205042553 -2.2742 -0.8335 2125451 Peakdale2_000112 CN(Cc1ccccc1)c2cc(nc(n2)c3ccccc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F03 compound treatment 1675450.0 89800.0 0.44 1353230.0 -330000.0 -1.46 1568110.0 -158494.375 -0.826123139406185 1573760.0 74948.125 0.36137066807931 -0.7447 -0.4195 2125452 Peakdale2_000113 C(c1ccccc1)n2cc(cn2)c3ccncn3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F04 compound treatment 1096290.0 -489000.0 -2.39 976890.0 -707000.0 -3.13 1189820.0 -536784.375 -2.79789104855732 1111870.0 -386941.875 -1.86568301577405 -5.0956 -0.9832 2125453 Peakdale2_000114 C1CC1Nc2cc(nc(n2)c3ccccc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F05 compound treatment 1687600.0 102000.0 0.5 1317670.0 -366000.0 -1.62 1557600.0 -169004.375 -0.8809046052794 1494600.0 -4211.875 -0.0203080208159516 -1.012 -0.5293 2125454 Peakdale2_000115 CN(Cc1ccccc1)C(=O)c2ccc(nc2)c3cnn(C)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F06 compound treatment 681920.0 -904000.0 -4.42 907200.0 -776000.0 -3.44 926750.0 -799854.375 -4.16909563726014 941540.0 -557271.875 -2.68694793592981 -7.3602 -0.9835 2125455 Peakdale2_000116 CCN(CC)c1cc(nc(n1)c2ccncc2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F07 compound treatment 1537820.0 -47800.0 -0.23 1262400.0 -421000.0 -1.87 1845790.0 119185.625 0.621233420410588 1678760.0 179948.125 0.86763977285448 -0.306 -0.1415 2125456 Peakdale2_000117 Clc1ccc(CNC(=O)c2ccc(nc2)c3cnn(c3)c4ccccc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F08 compound treatment 1342610.0 -243000.0 -1.19 1208290.0 -475000.0 -2.11 1538340.0 -188264.375 -0.981293856727366 1317390.0 -181421.875 -0.874745621360789 -2.5761 -0.9356 2125457 Peakdale2_000118 Cc1nc(NCCC#N)cc(n1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F09 compound treatment 1472540.0 -113000.0 -0.55 1246880.0 -437000.0 -1.94 1553640.0 -172964.375 -0.901545385950945 1308430.0 -190381.875 -0.917947251634936 -2.1543 -0.9016 2125458 Peakdale2_000119 Clc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)NC4CC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F10 compound treatment 1361980.0 -224000.0 -1.09 1463230.0 -220000.0 -0.98 1463000.0 -263604.375 -1.37398992132185 1541030.0 42218.125 0.203559355705107 -1.6206 -0.8023 2125459 Peakdale2_000120 Cc1nc(NCc2ccccc2)cc(n1)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F11 compound treatment 1621410.0 35800.0 0.18 1567330.0 -116000.0 -0.51 1677380.0 -49224.375 -0.256573113148699 1438080.0 -60731.875 -0.292825447500643 -0.4445 -0.6646 2125460 Peakdale2_000121 Cc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)NCC=C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F12 compound treatment 1571920.0 -13700.0 -0.07 1587260.0 -96100.0 -0.43 1539920.0 -186684.375 -0.973058393732154 1384750.0 -114061.875 -0.549961936621213 -1.0082 -0.8414 2125461 Peakdale2_000122 Cc1nc(NCCc2c[nH]c3ccccc23)cc(n1)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F13 compound treatment 1396640.0 -189000.0 -0.92 1324440.0 -359000.0 -1.59 1520400.0 -206204.375 -1.07480284795148 1150080.0 -348731.875 -1.68144927774111 -2.6364 -0.971 2125462 Peakdale2_000123 CCN(CC)c1cc(nc(n1)c2cccnc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F14 compound treatment 786400.0 -799000.0 -3.91 1377960.0 -305000.0 -1.35 1446570.0 -280034.375 -1.45962831183535 1569160.0 70348.125 0.339191259679636 -3.1929 -0.7254 2125463 Peakdale2_000124 CC(Nc1cc(nc(n1)c2ccccc2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F15 compound treatment 1373890.0 -212000.0 -1.04 1421610.0 -262000.0 -1.16 1692290.0 -34314.375 -0.178857446529324 1222570.0 -276241.875 -1.33193073102538 -1.8539 -0.9017 2125464 Peakdale2_000125 C1CC1Nc2cc(nc(n2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F16 compound treatment 1058420.0 -527000.0 -2.58 1197370.0 -486000.0 -2.16 1153960.0 -572644.375 -2.98480478463853 1166660.0 -332151.875 -1.60150697529185 -4.6607 -0.9766 2125465 Peakdale2_000126 CC(Nc1cc(nc(n1)c2cccnc2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F17 compound treatment 1296600.0 -289000.0 -1.41 1563200.0 -120000.0 -0.53 1460270.0 -266334.375 -1.38821955042117 1338650.0 -160161.875 -0.772238181670121 -2.0539 -0.9367 2125466 Peakdale2_000127 C(Nc1cc(nc(n1)c2ccncc2)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F18 compound treatment 1454960.0 -131000.0 -0.64 1647410.0 -36000.0 -0.16 1603790.0 -122814.375 -0.640147620628231 1159490.0 -339321.875 -1.63607792273221 -1.5376 -0.8194 2125467 Peakdale2_000128 Clc1ccc(CNc2cc(nc(n2)c3ccncc3)c4ccncc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F19 compound treatment 1633760.0 48200.0 0.24 1699410.0 16000.0 0.07 1643920.0 -82684.375 -0.430977285186546 1282170.0 -216641.875 -1.04456274393395 -0.5845 -0.5054 2125468 Peakdale2_000129 Cc1nc(cc(n1)c2cccnc2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F20 compound treatment 1391120.0 -194000.0 -0.95 1493240.0 -190000.0 -0.84 1481150.0 -245454.375 -1.27938634324394 1163710.0 -335101.875 -1.61573072633077 -2.3451 -0.9684 2125469 Peakdale2_000130 Cc1nc(NCc2ccncc2)cc(n1)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F21 compound treatment 1345500.0 -240000.0 -1.17 1318740.0 -365000.0 -1.62 1397130.0 -329474.375 -1.71732533112857 984240.0 -514571.875 -2.48106516665458 -3.4953 -0.9657 2125470 Peakdale2_000131 Cc1nc(cc(n1)c2cccnc2)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F22 compound treatment 1621440.0 35800.0 0.18 1638040.0 -45400.0 -0.2 1630970.0 -95634.375 -0.498476807837177 1210940.0 -287871.875 -1.38800606139238 -0.9561 -0.638 2125471 Peakdale2_000132 Cc1nc(NCc2ccccc2)cc(n1)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F23 mock treatment 1588420.0 2820.0 0.01 1720010.0 36600.0 0.16 1650880.0 -75724.375 -0.394699549460801 1597050.0 98238.125 0.473665977128964 0.1275 0.2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 F24 mock treatment 1770970.0 185000.0 0.91 1730000.0 46600.0 0.21 1735210.0 8605.625 0.0448552571127673 1370490.0 -128321.875 -0.618718102660203 0.2699 0.2414 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G01 compound treatment 1407290.0 -178000.0 -0.87 1585030.0 -98400.0 -0.44 1374470.0 -352134.375 -1.8354364649713 1472730.0 -26081.875 -0.125756642924837 -1.635 -0.7852 2125472 Peakdale2_000133 Cc1cnc(CNc2ncc(cn2)c3ccc(Cl)cc3)cn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G02 compound treatment 1422150.0 -163000.0 -0.8 1417630.0 -266000.0 -1.18 1259490.0 -467114.375 -2.43474882901528 1364160.0 -134651.875 -0.649238897262363 -2.5312 -0.8745 2125473 Peakdale2_000134 CC(Nc1cc(nc(C)n1)c2cncc(Br)c2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G03 compound treatment 1246880.0 -339000.0 -1.66 999400.0 -684000.0 -3.03 1210450.0 -516154.375 -2.69036092096794 1374920.0 -123891.875 -0.597358368049212 -3.9893 -0.9024 2125474 Peakdale2_000135 Clc1ccc(cc1)c2cnc(nc2)N3CCC4(CC3)OCCO4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G04 compound treatment 1554450.0 -31200.0 -0.15 1430890.0 -253000.0 -1.12 1303140.0 -423464.375 -2.20723113297666 1507680.0 8868.125 0.0427586448074696 -1.7184 -0.6929 2125475 Peakdale2_000136 COCCNc1ncc(cn1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G05 compound treatment 1465280.0 -120000.0 -0.59 1304550.0 -379000.0 -1.68 1426040.0 -300564.375 -1.56663720758959 1346720.0 -152091.875 -0.733327784760258 -2.2844 -0.9203 2125476 Peakdale2_000137 COc1ccc(cc1)c2cnc(nc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G06 compound treatment 1547520.0 -38100.0 -0.19 1334430.0 -349000.0 -1.55 1491610.0 -234994.375 -1.22486549328829 1407550.0 -91261.875 -0.440029216727176 -1.6994 -0.8369 2125477 Peakdale2_000138 OCCCNc1ncc(cn1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G07 compound treatment 1663060.0 77500.0 0.38 1443680.0 -240000.0 -1.06 1702240.0 -24364.375 -0.126994878932893 1729600.0 230788.125 1.1127704517761 0.1508 0.0949 2125478 Peakdale2_000139 CN(Cc1ccccc1)c2ncc(cn2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G08 compound treatment 1787200.0 202000.0 0.99 1381550.0 -302000.0 -1.34 1695260.0 -31344.375 -0.163376861025666 1624960.0 126148.125 0.608237126788726 0.0464 0.0261 2125479 Peakdale2_000140 Fc1ccc(cc1)c2cnc(NCCc3ccccc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G09 compound treatment 1516440.0 -69200.0 -0.34 1365380.0 -318000.0 -1.41 1429770.0 -296834.375 -1.54719526013887 1304490.0 -194321.875 -0.93694439709031 -2.1165 -0.9129 2125480 Peakdale2_000141 C=CCNc1ncc(cn1)c2cc3ccccc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G10 compound treatment 1259860.0 -326000.0 -1.59 1310680.0 -373000.0 -1.65 1267520.0 -459084.375 -2.39289391265353 1126630.0 -372181.875 -1.79451604447423 -3.7172 -0.9858 2125481 Peakdale2_000142 Fc1ccc(cc1)c2cnc(NC3CC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G11 compound treatment 1560730.0 -24900.0 -0.12 1497170.0 -186000.0 -0.83 1703690.0 -22914.375 -0.119437017323363 1623680.0 124868.125 0.602065465320991 -0.2325 -0.2244 2125482 Peakdale2_000143 Clc1ccc(cc1)c2cnc(NCc3ccccc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G12 compound treatment 1236850.0 -349000.0 -1.71 1347010.0 -336000.0 -1.49 1340720.0 -385884.375 -2.01135220933105 1163150.0 -335661.875 -1.61843082822291 -3.4141 -0.9938 2125483 Peakdale2_000144 Cc1nc(NCc2ccncc2)cc(n1)c3cncc(c3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G13 compound treatment 1684930.0 99300.0 0.49 1647300.0 -36100.0 -0.16 1819360.0 92755.625 0.483471846383084 1585680.0 86868.125 0.418844265497596 0.6141 0.7497 2125484 Peakdale2_000145 Cc1ccc(cc1)c2cnc(NCCc3ccccc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G14 compound treatment 1553060.0 -32500.0 -0.16 1682980.0 -423.0 0.0 1740840.0 14235.625 0.0742006094311497 1638100.0 139288.125 0.671593089043447 0.2923 0.4211 2123560 Peakdale2_000146 CC(=O)N1CCc2ccc(cc12)N(C3CCN(Cc4ccccc4)CC3)C(=O)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G15 compound treatment 1613800.0 28200.0 0.14 1697120.0 13700.0 0.06 1796530.0 69925.625 0.36447461842062 1423120.0 -75691.875 -0.364956740904801 0.0992 0.1845 2125485 Peakdale2_000147 Clc1ccc(CNc2ncc(cn2)c3ccc(Cl)cc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G16 compound treatment 650310.0 -935000.0 -4.58 733500.0 -950000.0 -4.21 723970.0 -1002634.375 -5.22604955255705 642100.0 -856711.875 -4.13073099053817 -9.0731 -0.9955 2125486 Peakdale2_000148 Cc1nc(NCC=C)cc(n1)c2cncc(c2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G17 compound treatment 1412450.0 -173000.0 -0.85 1388930.0 -294000.0 -1.31 1368640.0 -357964.375 -1.86582428095996 1064610.0 -434201.875 -2.0935523290281 -3.0563 -0.9529 2125487 Peakdale2_000149 FC(F)(F)Oc1ccc(cc1)c2cnc(NC3CC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G18 compound treatment 1457600.0 -128000.0 -0.63 1495930.0 -187000.0 -0.83 1510640.0 -215964.375 -1.12567507506115 1386020.0 -112791.875 -0.543838491258694 -1.5636 -0.9612 2125488 Peakdale2_000150 Cc1nc(cc(n1)c2cncc(c2)c3ccccc3)N4CCC(O)CC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G19 compound treatment 1710530.0 125000.0 0.61 1689660.0 6260.0 0.03 1603470.0 -123134.375 -0.641815562500679 1410440.0 -88371.875 -0.426094762319555 -0.2144 -0.2179 2125489 Peakdale2_000151 Cn1cc(cn1)c2ccccc2NC(=O)c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G20 compound treatment 1425920.0 -160000.0 -0.78 1510360.0 -173000.0 -0.77 1377980.0 -348624.375 -1.81714122755788 1422850.0 -75961.875 -0.366258575745651 -1.8661 -0.8667 2125490 Peakdale2_000152 Cc1nc(NCc2ccco2)cc(n1)c3cncc(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G21 compound treatment 1689760.0 104000.0 0.51 1708330.0 24900.0 0.11 1784560.0 57955.625 0.302083167754361 1522970.0 24158.125 0.116481069683778 0.5194 0.8461 2125491 Peakdale2_000153 Cn1cc(cn1)c2ccccc2NC(=O)Cc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G22 compound treatment 920010.0 -666000.0 -3.26 1566900.0 -117000.0 -0.52 1553280.0 -173324.375 -0.903421820557449 1194820.0 -303991.875 -1.46573042300167 -3.0714 -0.8256 2125492 Peakdale2_000154 Cc1nc(NCc2ccc(Cl)cc2)cc(n1)c3cncc(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G23 mock treatment 1522400.0 -63200.0 -0.31 1785850.0 102000.0 0.45 1662300.0 -64304.375 -0.335174873887812 1391580.0 -107231.875 -0.517030336758218 -0.3536 -0.4282 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 G24 mock treatment 1530130.0 -55500.0 -0.27 1703570.0 20200.0 0.09 1801190.0 74585.625 0.388764021938144 1637940.0 139128.125 0.670821631359981 0.4388 0.531 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H01 compound treatment 971550.0 -614000.0 -3.0 813250.0 -870000.0 -3.86 1126260.0 -600344.375 -3.12918600297231 1292900.0 -205911.875 -0.992826863036445 -5.4929 -0.9325 2125493 Peakdale2_000155 Cn1cc(cn1)c2cnc3ccccc3n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H02 compound treatment 1528860.0 -56700.0 -0.28 1495550.0 -188000.0 -0.83 1498770.0 -227834.375 -1.18754529389227 1437500.0 -61311.875 -0.295621981603211 -1.297 -0.8611 2125494 Peakdale2_000156 C=CCNc1cc(nc(n1)c2ccccc2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H03 compound treatment 1590810.0 5210.0 0.03 1354830.0 -329000.0 -1.46 1481120.0 -245484.375 -1.27954271279448 1379090.0 -119721.875 -0.577252252173855 -1.6442 -0.8126 2125495 Peakdale2_000157 Cn1cc(cn1)c2ccncn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H04 compound treatment 880030.0 -706000.0 -3.45 933200.0 -750000.0 -3.33 1014360.0 -712244.375 -3.71244442649398 1091810.0 -407001.875 -1.96240452283872 -6.2272 -0.977 2125496 Peakdale2_000158 CCN(CC)c1cc(nc(n1)c2cccnc2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H05 compound treatment 1643070.0 57500.0 0.28 1559550.0 -124000.0 -0.55 1572910.0 -153694.375 -0.801104011319465 1560450.0 61638.125 0.297195032035905 -0.386 -0.3662 2125497 Peakdale2_000159 Cn1cc(cn1)c2ccc(cn2)C(=O)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H06 compound treatment 1363880.0 -222000.0 -1.08 1233450.0 -450000.0 -2.0 1180570.0 -546034.375 -2.84610499330777 1497650.0 -1161.875 -0.00560210872486334 -2.9661 -0.8146 2125498 Peakdale2_000160 C1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H07 compound treatment 1477960.0 -108000.0 -0.53 1431580.0 -252000.0 -1.12 1405860.0 -320744.375 -1.67182179192085 1434780.0 -64031.875 -0.308736762222148 -1.812 -0.8624 2125499 Peakdale2_000161 O=C(NC1CC1)c2ccc(nc2)c3cnn(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H08 compound treatment 1524610.0 -61000.0 -0.3 1345120.0 -338000.0 -1.5 1434640.0 -291964.375 -1.52181126976755 1465820.0 -32991.875 -0.159073971629565 -1.7398 -0.8041 2125500 Peakdale2_000162 COCCNc1cc(nc(C)n1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H09 compound treatment 1695680.0 110000.0 0.54 1594780.0 -88600.0 -0.39 1576110.0 -150494.375 -0.784424592594985 1668980.0 170168.125 0.820484421952564 0.0908 0.069 2125501 Peakdale2_000163 CN(Cc1ccccc1)C(=O)c2ccc(nc2)c3cnn(c3)c4ccc(F)cc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H10 compound treatment 1531910.0 -53700.0 -0.26 1521950.0 -161000.0 -0.72 1466720.0 -259884.375 -1.35460009705464 1385870.0 -112941.875 -0.544561732836944 -1.439 -0.8736 2125502 Peakdale2_000164 Cc1nc(NCc2ccco2)cc(n1)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H11 compound treatment 1710800.0 125000.0 0.61 1702470.0 19100.0 0.08 1773090.0 46485.625 0.242297876263802 1475380.0 -23431.875 -0.112979375042416 0.4133 0.6134 2125503 Peakdale2_000165 Cc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)NCc4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H12 compound treatment 1336160.0 -249000.0 -1.22 1574760.0 -109000.0 -0.48 1608480.0 -118124.375 -0.615701847560164 1317980.0 -180831.875 -0.871900871153004 -1.595 -0.9429 2125504 Peakdale2_000166 CCN(CC)c1cc(nc(n1)c2ccccc2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H13 compound treatment 1201960.0 -384000.0 -1.88 1201860.0 -482000.0 -2.14 1202780.0 -523824.375 -2.73033940272318 1112510.0 -386301.875 -1.86259718504019 -4.3029 -0.9869 2125505 Peakdale2_000167 C1CN(CCO1)c2cc(nc(n2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H14 compound treatment 1668980.0 83400.0 0.41 1768030.0 84600.0 0.38 1722400.0 -4204.375 -0.0219145409686677 1742530.0 243718.125 1.17511387582127 0.9682 0.7451 2125506 Peakdale2_000168 Clc1ccc(CNc2cc(nc(n2)c3ccccc3)c4ccncc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H15 compound treatment 1554090.0 -31500.0 -0.15 1559150.0 -124000.0 -0.55 1489930.0 -236674.375 -1.23362218811864 1158460.0 -340351.875 -1.64104418156953 -1.79 -0.8399 2125507 Peakdale2_000169 CCN(CC)c1cc(nc(n1)c2ccncc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H16 compound treatment 1196670.0 -389000.0 -1.9 1443790.0 -240000.0 -1.06 1509120.0 -217484.375 -1.13359779895528 1153440.0 -345371.875 -1.6652486663883 -2.8823 -0.9711 2125508 Peakdale2_000170 C1CC1Nc2cc(nc(n2)c3cccnc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H17 compound treatment 1331950.0 -254000.0 -1.24 1413560.0 -270000.0 -1.2 1418250.0 -308354.375 -1.607241167547 1071280.0 -427531.875 -2.06139218684857 -3.0533 -0.9751 2125509 Peakdale2_000171 CC(Nc1cc(nc(n1)c2ccncc2)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H18 compound treatment 1072720.0 -513000.0 -2.51 1275010.0 -408000.0 -1.81 1268250.0 -458354.375 -2.38908892025701 975680.0 -523131.875 -2.52233815272006 -4.6161 -0.9921 2125510 Peakdale2_000172 C1CC1Nc2cc(nc(n2)c3ccncc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H19 compound treatment 1527090.0 -58500.0 -0.29 1622000.0 -61400.0 -0.27 1188190.0 -538414.375 -2.8063871274701 1552850.0 54038.125 0.260550792071226 -1.5522 -0.5454 2125511 Peakdale2_000173 CN(Cc1ccccc1)c2cc(nc(C)n2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H20 compound treatment 1517920.0 -67700.0 -0.33 1517690.0 -166000.0 -0.73 1373000.0 -353604.375 -1.84309857294785 1486400.0 -12411.875 -0.0598452270936316 -1.4845 -0.7376 2125512 Peakdale2_000174 Cc1nc(cc(n1)c2ccc(F)cc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H21 compound treatment 1543360.0 -42200.0 -0.21 1615640.0 -67800.0 -0.3 1610090.0 -116514.375 -0.60731001501441 1282010.0 -216801.875 -1.04533420161741 -1.0799 -0.8552 2125513 Peakdale2_000175 Cc1nc(NCCc2ccccc2)cc(n1)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H22 compound treatment 1383970.0 -202000.0 -0.99 1453370.0 -230000.0 -1.02 1374240.0 -352364.375 -1.83663529819212 1121310.0 -377501.875 -1.82016701244951 -2.8318 -0.96 2125514 Peakdale2_000176 Cc1nc(NCc2ccco2)cc(n1)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H23 mock treatment 1649610.0 64000.0 0.31 1798020.0 115000.0 0.51 1847250.0 120645.625 0.628843405203632 1496920.0 -1891.875 -0.00912188440568119 0.7206 0.831 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 H24 mock treatment 1777180.0 192000.0 0.94 1736250.0 52800.0 0.23 1732320.0 5715.625 0.0297916570772211 1719770.0 220958.125 1.0653740203481 1.1335 0.7879 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I01 compound treatment 858080.0 -728000.0 -3.56 809890.0 -874000.0 -3.87 810840.0 -915764.375 -4.77325545737092 929790.0 -569021.875 -2.74360185955942 -7.4754 -0.9816 2125515 Peakdale2_000177 Cc1cnc(CNc2ncc(cn2)c3cccs3)cn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I02 compound treatment 1558790.0 -26800.0 -0.13 1510430.0 -173000.0 -0.77 1533770.0 -192834.375 -1.00511415159326 1475920.0 -22891.875 -0.110375705360715 -1.0069 -0.7891 2125516 Peakdale2_000178 Cc1nc(NCc2ccc(Cl)cc2)cc(n1)c3cncc(Br)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I03 compound treatment 778530.0 -807000.0 -3.95 640840.0 -1040000.0 -4.62 728420.0 -998184.375 -5.20285473589332 630800.0 -868011.875 -4.18521518943302 -8.9805 -0.9944 2125517 Peakdale2_000179 C1COC2(CCN(CC2)c3ncc(cn3)c4cccs4)O1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I04 compound treatment 381370.0 -1200000.0 -5.89 493050.0 -1190000.0 -5.28 512540.0 -1214064.375 -6.32809002159356 452680.0 -1046131.875 -5.04404045555257 -11.2719 -0.996 2125518 Peakdale2_000180 Fc1ccc(cc1)c2cnc(nc2)N3CCC4(CC3)OCCO4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I05 compound treatment 1550760.0 -34800.0 -0.17 1446410.0 -237000.0 -1.05 1543850.0 -182754.375 -0.952573982611151 1468360.0 -30451.875 -0.146827080904527 -1.1605 -0.808 2125519 Peakdale2_000181 Clc1ccc(cc1)c2cnc(nc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I06 compound treatment 1597330.0 11700.0 0.06 1345600.0 -338000.0 -1.5 1450400.0 -276204.375 -1.43966513254949 1190200.0 -308611.875 -1.48800626361178 -2.1842 -0.8545 2125520 Peakdale2_000182 Fc1ccc(cc1)c2cnc(NCC=C)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I07 compound treatment 1590030.0 4430.0 0.02 1725920.0 42500.0 0.19 1623360.0 -103244.375 -0.538142550491331 1508810.0 9998.125 0.0482070646969547 -0.1399 -0.2442 2125521 Peakdale2_000183 CN(Cc1ccccc1)c2ncc(cn2)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I08 compound treatment 1687130.0 102000.0 0.5 1686910.0 3510.0 0.02 1731610.0 5005.625 0.026090911047727 1571650.0 72838.125 0.35119706987859 0.4448 0.7302 2125522 Peakdale2_000184 C(Cc1ccccc1)Nc2ncc(cn2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I09 compound treatment 1428160.0 -157000.0 -0.77 1422560.0 -261000.0 -1.16 1494460.0 -232144.375 -1.2100103859868 1399460.0 -99351.875 -0.479036045847472 -1.8081 -0.9496 2125523 Peakdale2_000185 CN1CCN(CC1)c2ncc(cn2)c3ccc(C)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I10 compound treatment 1142340.0 -443000.0 -2.17 1276380.0 -407000.0 -1.81 966970.0 -759634.375 -3.95945619316683 1162920.0 -335891.875 -1.61953979864289 -4.7766 -0.9321 2125524 Peakdale2_000186 C1CC1Nc2ncc(cn2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I11 compound treatment 1780170.0 195000.0 0.95 1621120.0 -62300.0 -0.28 1707790.0 -18814.375 -0.0980665120826228 1500120.0 1308.125 0.00630726926365733 0.2921 0.2932 2125525 Peakdale2_000187 Cc1ccc(cc1)c2cnc(NCc3ccco3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I12 compound treatment 1330810.0 -255000.0 -1.25 1384320.0 -299000.0 -1.33 1419970.0 -306634.375 -1.59827597998259 1228640.0 -270171.875 -1.30266355515885 -2.7371 -0.9951 2125526 Peakdale2_000188 Cc1nc(NCc2ccncc2)cc(n1)c3cncc(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I13 compound treatment 1508340.0 -77300.0 -0.38 1397720.0 -286000.0 -1.27 1759620.0 33015.625 0.172087948070443 1400410.0 -98401.875 -0.474455515851888 -0.9737 -0.688 2125527 Peakdale2_000189 C(Cc1ccccc1)Nc2ncc(cn2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I14 compound treatment 1328960.0 -257000.0 -1.26 1613150.0 -70300.0 -0.31 1019520.0 -707084.375 -3.68554886380075 1309870.0 -188941.875 -0.911004132483734 -3.082 -0.7684 2125528 Peakdale2_000190 Cc1nc(cc(n1)c2cncc(c2)c3ccccc3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I15 compound treatment 1426730.0 -159000.0 -0.78 1474740.0 -209000.0 -0.93 1452480.0 -274124.375 -1.42882351037858 1255880.0 -242931.875 -1.1713228845486 -2.1515 -0.9745 2125529 Peakdale2_000191 Clc1ccc(CNc2ncc(cn2)c3cccs3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I16 compound treatment 1324900.0 -261000.0 -1.28 1428110.0 -255000.0 -1.13 1449550.0 -277054.375 -1.44409560314818 890990.0 -607821.875 -2.93068034780015 -3.3913 -0.9202 2125530 Peakdale2_000192 Cc1nc(NCC=C)cc(n1)c2cncc(c2)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I17 compound treatment 1177310.0 -408000.0 -2.0 1278400.0 -405000.0 -1.8 1232690.0 -493914.375 -2.5744389608328 1037300.0 -461511.875 -2.22523051237486 -4.2969 -0.9911 2125531 Peakdale2_000193 Clc1ccc(cc1)c2cnc(NC3CC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I18 compound treatment 1390520.0 -195000.0 -0.95 1552010.0 -131000.0 -0.58 1492160.0 -234444.375 -1.22199871819502 1250360.0 -248451.875 -1.19793817462821 -1.9786 -0.9679 2125532 Peakdale2_000194 Cc1nc(cc(n1)c2cncc(c2)c3ccc(F)cc3)N4CCC(O)CC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I19 compound treatment 1754250.0 169000.0 0.83 1800160.0 117000.0 0.52 1754800.0 28195.625 0.146964573616695 1359860.0 -138951.875 -0.669971822505536 0.41 0.3441 2125533 Peakdale2_000195 Cn1cc(cn1)c2ccccc2NC(=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I20 compound treatment 1477550.0 -108000.0 -0.53 1589280.0 -94100.0 -0.42 1527680.0 -198924.375 -1.03685717035329 1485930.0 -12881.875 -0.0621113840388157 -1.0226 -0.826 2125534 Peakdale2_000196 Cc1nc(NCc2ccco2)cc(n1)c3cncc(c3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I21 compound treatment 1674910.0 89300.0 0.44 1619370.0 -64000.0 -0.28 1587200.0 -139404.375 -0.726619982077958 1305030.0 -193781.875 -0.934340727408609 -0.754 -0.583 2125535 Peakdale2_000197 Cn1cc(cn1)c2ccccc2NC(=O)C(c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I22 compound treatment 1360530.0 -225000.0 -1.1 1500850.0 -183000.0 -0.81 1446110.0 -280494.375 -1.46202597827699 903170.0 -595641.875 -2.87195313164623 -3.1225 -0.892 2125536 Peakdale2_000198 Cc1nc(NCc2ccc(Cl)cc2)cc(n1)c3cncc(c3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I23 mock treatment 1559040.0 -26600.0 -0.13 1687580.0 4180.0 0.02 1702890.0 -23714.375 -0.123606872004483 1340100.0 -158711.875 -0.765246846413702 -0.5002 -0.6362 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 I24 mock treatment 1527920.0 -57700.0 -0.28 1559120.0 -124000.0 -0.55 1767970.0 41365.625 0.215610806304634 1679960.0 181148.125 0.873425705480482 0.1278 0.117 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J01 compound treatment 1410280.0 -175000.0 -0.86 1252740.0 -431000.0 -1.91 1200960.0 -525644.375 -2.73982582212272 1253650.0 -245161.875 -1.18207507601193 -3.3449 -0.9176 2125537 Peakdale2_000199 Cn1cc(cn1)c2ccnc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J02 compound treatment 1303680.0 -282000.0 -1.38 1534370.0 -149000.0 -0.66 1336640.0 -389964.375 -2.03261846820476 1412100.0 -86711.875 -0.418090888853585 -2.2456 -0.871 2125538 Peakdale2_000200 CN1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J03 compound treatment 1694350.0 109000.0 0.53 1362600.0 -321000.0 -1.42 1307410.0 -419194.375 -2.18497453361619 1683610.0 184798.125 0.891024583884571 -1.0922 -0.3892 2125539 Peakdale2_000201 OCCn1cc(cn1)c2ccncn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J04 compound treatment 866480.0 -719000.0 -3.52 1012320.0 -671000.0 -2.98 929220.0 -797384.375 -4.15622121093218 1037040.0 -461771.875 -2.22648413111049 -6.4389 -0.9766 2125540 Peakdale2_000202 C1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J05 compound treatment 1673060.0 87500.0 0.43 1694080.0 10700.0 0.05 1467200.0 -259404.375 -1.35209818424597 1554260.0 55448.125 0.267349262906778 -0.3047 -0.211 2123428 Peakdale2_000203 O=C(NCCc1ccccc1)c2ccc(CCN3CCCC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J06 compound treatment 1355970.0 -230000.0 -1.12 1296130.0 -387000.0 -1.72 1215750.0 -510854.375 -2.66273563370552 1274350.0 -224461.875 -1.08226773821339 -3.2931 -0.9324 2125541 Peakdale2_000204 CN(Cc1ccccc1)c2cc(nc(n2)c3ccncc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J07 compound treatment 1645990.0 60400.0 0.3 1549560.0 -134000.0 -0.59 1524960.0 -201644.375 -1.0510346762691 1549390.0 50578.125 0.243868019666254 -0.5526 -0.4364 2123503 Peakdale2_000205 CCCN1CCC(CC1)N(C(=O)CC)c2ccc3[nH]c(cc3c2)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J08 compound treatment 1450080.0 -136000.0 -0.66 1343740.0 -340000.0 -1.51 1406920.0 -319684.375 -1.66629673446836 1407770.0 -91041.875 -0.438968462412409 -2.1374 -0.897 2125542 Peakdale2_000206 CCN(CC)c1cc(nc(C)n1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J09 compound treatment 1659490.0 73900.0 0.36 1548020.0 -135000.0 -0.6 1604690.0 -121914.375 -0.635456534111971 1445930.0 -52881.875 -0.254975804905547 -0.5646 -0.5763 2125543 Peakdale2_000207 Fc1ccc(c(F)c1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J10 compound treatment 1222720.0 -363000.0 -1.78 1314620.0 -369000.0 -1.64 1314560.0 -412044.375 -2.14770645740367 1339420.0 -159391.875 -0.768525541568436 -3.1637 -0.9525 2125544 Peakdale2_000208 Cc1nc(cc(n1)c2ccncc2)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J11 compound treatment 1709480.0 124000.0 0.61 1626720.0 -56700.0 -0.25 1654270.0 -72334.375 -0.377029790249555 1643360.0 144548.125 0.696954760387423 0.3374 0.3279 2125545 Peakdale2_000209 Cc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)NC4CC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J12 compound treatment 995450.0 -590000.0 -2.89 1209190.0 -474000.0 -2.1 1219370.0 -507234.375 -2.64386704127345 1092920.0 -405891.875 -1.95705253515967 -4.7959 -0.9876 2125546 Peakdale2_000210 C1CN(CCO1)c2cc(nc(n2)c3ccccc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J13 compound treatment 1473020.0 -113000.0 -0.55 1334900.0 -349000.0 -1.55 1619680.0 -106924.375 -0.557323882024484 1175870.0 -322941.875 -1.55709994238728 -2.1054 -0.9038 2125547 Peakdale2_000211 C1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J14 compound treatment 1480960.0 -105000.0 -0.51 1517240.0 -166000.0 -0.74 1478260.0 -248344.375 -1.29444994327948 1508730.0 9918.125 0.0478213358552213 -1.2478 -0.7919 2125548 Peakdale2_000212 C1CC1Nc2cc(nc(n2)c3ccccc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J15 compound treatment 1101160.0 -484000.0 -2.37 1286120.0 -397000.0 -1.76 1326920.0 -399684.375 -2.08328220258037 1036320.0 -462491.875 -2.22995569068609 -4.2228 -0.9943 2125549 Peakdale2_000213 C1CN(CCO1)c2cc(nc(n2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J16 compound treatment 367550.0 -1220000.0 -5.96 478500.0 -1200000.0 -5.34 507770.0 -1218834.375 -6.35295278012974 626000.0 -872811.875 -4.20835891993702 -10.9326 -0.9892 2125550 Peakdale2_000214 CCN(CC)c1cc(nc(n1)c2ccncc2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J17 compound treatment 1328640.0 -257000.0 -1.26 1502280.0 -181000.0 -0.8 1420230.0 -306374.375 -1.59692077721123 1318350.0 -180461.875 -0.870116875259987 -2.2639 -0.9624 2125551 Peakdale2_000215 C1CC1Nc2cc(nc(n2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J18 compound treatment 1502330.0 -83300.0 -0.41 1752930.0 69500.0 0.31 1748640.0 22035.625 0.11485669257207 1392890.0 -105921.875 -0.510714026974833 -0.2475 -0.3383 2125552 Peakdale2_000216 CN(C)CCNc1cc(nc(C)n1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J19 compound treatment 1485550.0 -100000.0 -0.49 1785520.0 102000.0 0.45 1633050.0 -93554.375 -0.487635185666265 1480590.0 -18221.875 -0.0878587842245243 -0.3061 -0.3684 2125553 Peakdale2_000217 Cc1nc(NCCCO)cc(n1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J20 compound treatment 1421060.0 -165000.0 -0.81 1701990.0 18600.0 0.08 1707140.0 -19464.375 -0.101454519011033 1467270.0 -31541.875 -0.152082636373146 -0.4881 -0.5883 2125554 Peakdale2_000218 Cc1nc(cc(n1)c2ccc(F)cc2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J21 compound treatment 1404330.0 -181000.0 -0.89 1625640.0 -57800.0 -0.26 1598530.0 -128074.375 -0.667564415156595 1498170.0 -641.875 -0.00309487125359583 -0.9069 -0.796 2125555 Peakdale2_000219 CC(Nc1cc(nc(C)n1)c2cccnc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J22 compound treatment 1649730.0 64100.0 0.31 1739360.0 56000.0 0.25 1624960.0 -101644.375 -0.529802841129091 1135200.0 -363611.875 -1.75319484230353 -0.8605 -0.459 2125556 Peakdale2_000220 Cc1nc(cc(n1)c2ccc(F)cc2)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J23 mock treatment 1540540.0 -45100.0 -0.22 1776750.0 93300.0 0.41 1840390.0 113785.625 0.593086901313027 1557370.0 58558.125 0.282344471629167 0.5344 0.6621 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 J24 mock treatment 1533520.0 -52100.0 -0.25 1675230.0 -8170.0 -0.04 1616840.0 -109764.375 -0.57212686614246 1487200.0 -11611.875 -0.0559879386762969 -0.4596 -0.7297 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K01 compound treatment 500990.0 -1080000.0 -5.31 460510.0 -1220000.0 -5.42 838740.0 -887864.375 -4.62783177536686 510650.0 -988161.875 -4.76453169361146 -10.0615 -0.9977 2125557 Peakdale2_000221 Cc1cnc(CNc2ncc(cn2)c3cc4ccccc4s3)cn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K02 compound treatment 1598620.0 13000.0 0.06 1330650.0 -353000.0 -1.56 1433920.0 -292684.375 -1.52556413898056 1588260.0 89448.125 0.4312840206435 -1.2975 -0.5823 2125558 Peakdale2_000222 Cc1nc(NC2CCCCC2)cc(n1)c3cncc(Br)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K03 compound treatment 1578080.0 -7520.0 -0.04 1518900.0 -165000.0 -0.73 1381210.0 -345394.375 -1.80030543928286 1600290.0 101478.125 0.48928799521917 -1.0387 -0.5184 2125559 Peakdale2_000223 CCN(CC)c1ncc(cn1)c2ccc(C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K04 compound treatment 1585720.0 116.0 0.0 1445360.0 -238000.0 -1.06 1378650.0 -347954.375 -1.81364897426244 1480190.0 -18621.875 -0.0897874284331916 -1.4793 -0.7043 2125560 Peakdale2_000224 CCN(CC)c1ncc(cn1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K05 compound treatment 1003560.0 -582000.0 -2.85 1175430.0 -508000.0 -2.25 900250.0 -826354.375 -4.30722207357224 1088000.0 -410811.875 -1.98077485892628 -5.6945 -0.9536 2125561 Peakdale2_000225 C1CN(CCO1)c2ncc(cn2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K06 compound treatment 1171110.0 -414000.0 -2.03 1218410.0 -465000.0 -2.06 1201730.0 -524874.375 -2.73581233699215 1192640.0 -306171.875 -1.47624153393891 -4.1512 -0.9776 2125562 Peakdale2_000226 CN1CCN(CC1)c2ncc(cn2)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K07 compound treatment 1634810.0 49200.0 0.24 1637310.0 -46100.0 -0.2 1619240.0 -107364.375 -0.5596173020991 1468000.0 -30811.875 -0.148562860692328 -0.3359 -0.5093 2125563 Peakdale2_000227 OCCCNc1ncc(cn1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K08 compound treatment 1680450.0 94800.0 0.46 1579650.0 -104000.0 -0.46 1508640.0 -217964.375 -1.13609971176395 1613470.0 114658.125 0.552836821894758 -0.2896 -0.2036 2125564 Peakdale2_000228 Fc1ccc(cc1)c2cnc(nc2)N3CCN(CC3)c4ccccn4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K09 compound treatment 1637050.0 51400.0 0.25 1560990.0 -122000.0 -0.54 1680050.0 -46554.375 -0.242656223150461 1533610.0 34798.125 0.167783005634328 -0.183 -0.2743 2125565 Peakdale2_000229 Cc1ccc(cc1)c2cnc(nc2)N3CCC(O)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K10 compound treatment 1677200.0 91600.0 0.45 1715610.0 32200.0 0.14 1525280.0 -201324.375 -1.04936673439665 1683600.0 184788.125 0.890976367779354 0.2163 0.1487 2125566 Peakdale2_000230 Fc1ccc(cc1)c2cnc(NCCc3c[nH]c4ccccc34)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K11 compound treatment 1678850.0 93200.0 0.46 1766560.0 83200.0 0.37 1768930.0 42325.625 0.220614631921978 1670800.0 171988.125 0.829259753102 0.9375 0.9019 2125567 Peakdale2_000231 COc1ccc(cc1)c2cnc(NCc3ccco3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K12 compound treatment 1496750.0 -88900.0 -0.43 1565280.0 -118000.0 -0.52 1463570.0 -263034.375 -1.37101889986155 1308640.0 -190171.875 -0.916934713425386 -1.6233 -0.9097 2125568 Peakdale2_000232 Cc1nc(NCc2ccncc2)cc(n1)c3cncc(c3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K13 compound treatment 1548100.0 -37500.0 -0.18 1637600.0 -45800.0 -0.2 1634240.0 -92364.375 -0.481432526828098 1327880.0 -170931.875 -0.824166926988488 -0.8461 -0.8521 2125569 Peakdale2_000233 C(Cc1ccccc1)Nc2ncc(cn2)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K14 compound treatment 1577840.0 -7760.0 -0.04 1650570.0 -32800.0 -0.15 1604230.0 -122374.375 -0.637854200553615 1531400.0 32588.125 0.157127246381441 -0.3322 -0.4929 2125570 Peakdale2_000234 Cc1nc(cc(n1)c2cncc(c2)c3ccc(F)cc3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K15 compound treatment 1653210.0 67600.0 0.33 1815430.0 132000.0 0.59 1678200.0 -48404.375 -0.252299012100551 1470820.0 -27991.875 -0.134965919021223 0.2645 0.362 2125571 Peakdale2_000235 Cc1ccc(cc1)c2cnc(NC3CCCCC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K16 compound treatment 1095460.0 -490000.0 -2.4 1478600.0 -205000.0 -0.91 1226790.0 -499814.375 -2.60519163910606 1150830.0 -347981.875 -1.67783306984986 -3.7949 -0.9434 2125572 Peakdale2_000236 Cc1nc(NCC=C)cc(n1)c2cncc(c2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K17 compound treatment 1677350.0 91700.0 0.45 1811800.0 128000.0 0.57 1600170.0 -126434.375 -0.659016213060299 1417800.0 -81011.875 -0.390607708880076 -0.0156 -0.0148 2122941 Peakdale2_000237 O=C(NCCN1CCOCC1)c2ccc3cc[nH]c3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K18 compound treatment 1695300.0 110000.0 0.54 1794240.0 111000.0 0.49 1715690.0 -10914.375 -0.0568891971065622 1448610.0 -50201.875 -0.242053888707476 0.3647 0.4742 2125573 Peakdale2_000238 Cc1ccc(cc1)c2cncc(c2)c3cc(NCc4ccccc4)nc(C)n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K19 compound treatment 1655320.0 69700.0 0.34 1836890.0 153000.0 0.68 1830880.0 104275.625 0.543517753791213 1364700.0 -134111.875 -0.646635227580662 0.4594 0.4039 2125574 Peakdale2_000239 CC(=O)Nc1ccccc1c2cnn(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K20 compound treatment 1691200.0 106000.0 0.52 1763840.0 80400.0 0.36 1732370.0 5765.625 0.0300522729947911 1597120.0 98308.125 0.474003489865481 0.6887 0.8748 2125575 Peakdale2_000240 CC(Nc1cc(nc(C)n1)c2cncc(c2)c3ccc(C)cc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K21 compound treatment 1633670.0 48100.0 0.24 1766800.0 83400.0 0.37 1577410.0 -149194.375 -0.777648578738165 1519220.0 20408.125 0.0984000302275216 -0.0371 -0.0413 2125576 Peakdale2_000241 Cn1cc(cn1)c2ccccc2NC(=O)Nc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K22 compound treatment 1379040.0 -207000.0 -1.01 1345970.0 -337000.0 -1.5 1259890.0 -466714.375 -2.43266390167472 1116010.0 -382801.875 -1.84572154821435 -3.3928 -0.9564 2125577 Peakdale2_000242 Cc1ccc(cc1)c2cncc(c2)c3cc(NC4CC4)nc(C)n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K23 mock treatment 1521890.0 -63700.0 -0.31 1809640.0 126000.0 0.56 1813760.0 87155.625 0.454282863615243 1642890.0 144078.125 0.694688603442238 0.6985 0.6661 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 K24 mock treatment 1719200.0 134000.0 0.65 1686450.0 3050.0 0.01 1721920.0 -4684.375 -0.0244164537773397 1524480.0 25668.125 0.123761701571497 0.3833 0.5756 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L01 compound treatment 1678130.0 92500.0 0.45 1548720.0 -135000.0 -0.6 1704640.0 -21964.375 -0.114485314889533 1692160.0 193348.125 0.932249353844835 0.3366 0.2801 2125578 Peakdale2_000243 OCCn1cc(cn1)c2ccnc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L02 compound treatment 1164640.0 -421000.0 -2.06 1292230.0 -391000.0 -1.73 1382730.0 -343874.375 -1.79238271538873 1428080.0 -70731.875 -0.341041552717326 -2.9641 -0.9112 2125579 Peakdale2_000244 OC1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L03 compound treatment 1632440.0 46800.0 0.23 1581300.0 -102000.0 -0.45 1583810.0 -142794.375 -0.744289741289204 1498950.0 138.125 6.65984953305432E-4 -0.4836 -0.5368 2125580 Peakdale2_000245 Clc1ccc(cc1)c2cnn(Cc3ccccc3)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L04 compound treatment 958340.0 -627000.0 -3.07 1193760.0 -490000.0 -2.17 1152160.0 -574444.375 -2.99418695767105 1300500.0 -198311.875 -0.956182623071766 -4.5956 -0.9378 2125581 Peakdale2_000246 CN(Cc1ccccc1)c2cc(nc(n2)c3cccnc3)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L05 compound treatment 1661570.0 76000.0 0.37 1722680.0 39300.0 0.17 1444020.0 -282584.375 -1.47291972363142 1598830.0 100018.125 0.482248443857534 -0.2224 -0.1387 2125582 Peakdale2_000247 Cn1cc(cn1)c2ccc(cn2)C(=O)NCC=C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L06 compound treatment 1242470.0 -343000.0 -1.68 1313280.0 -370000.0 -1.64 1181220.0 -545384.375 -2.84271698637936 1382900.0 -115911.875 -0.558881916086299 -3.361 -0.9013 2125583 Peakdale2_000248 C=CCNc1cc(nc(n1)c2ccncc2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L07 compound treatment 1696160.0 111000.0 0.54 1832610.0 149000.0 0.66 1628720.0 -97884.375 -0.510204524127827 1644770.0 145958.125 0.703753231222975 0.6981 0.5727 2125584 Peakdale2_000249 CN(Cc1ccccc1)C(=O)c2ccc(nc2)c3cnn(c3)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L08 compound treatment 1703460.0 118000.0 0.58 1708960.0 25600.0 0.11 1677920.0 -48684.375 -0.253758461238943 1567680.0 68868.125 0.332055276107567 0.3842 0.5327 2125585 Peakdale2_000250 Cc1nc(cc(n1)c2ccncc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L09 compound treatment 1586990.0 1390.0 0.01 1583370.0 -100000.0 -0.44 1578930.0 -147674.375 -0.769725854844037 1559840.0 61028.125 0.294253849617687 -0.4562 -0.4874 2125586 Peakdale2_000251 Fc1ccc(c(F)c1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L10 compound treatment 1635890.0 50300.0 0.25 1639360.0 -44000.0 -0.2 1651290.0 -75314.375 -0.392562498936727 1438010.0 -60801.875 -0.29316296023716 -0.3175 -0.5455 2125587 Peakdale2_000252 Cc1nc(NCCc2ccccc2)cc(n1)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L11 compound treatment 1750000.0 164000.0 0.8 1800170.0 117000.0 0.52 1731200.0 4595.625 0.023953860523653 1497520.0 -1291.875 -0.00622891809268022 0.67 0.7001 2125588 Peakdale2_000253 CN(Cc1ccccc1)C(=O)c2ccc(nc2)c3cnn(c3)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L12 compound treatment 1219590.0 -366000.0 -1.79 1296020.0 -387000.0 -1.72 1227360.0 -499244.375 -2.60222061764576 1275520.0 -223291.875 -1.07662645390304 -3.5939 -0.9574 2125589 Peakdale2_000254 C1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L13 compound treatment 1692520.0 107000.0 0.52 1791750.0 108000.0 0.48 1797470.0 70865.625 0.369374197670936 1675400.0 176588.125 0.851439161501675 1.1122 0.9517 2125590 Peakdale2_000255 CN(Cc1ccccc1)c2cc(nc(n2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L14 compound treatment 1158690.0 -427000.0 -2.09 1391570.0 -292000.0 -1.29 1296800.0 -429804.375 -2.24027723132454 1490620.0 -8191.875 -0.0394980306921914 -2.8315 -0.8514 2125591 Peakdale2_000256 CCN(CC)c1cc(nc(n1)c2cccnc2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L15 compound treatment 1576650.0 -8950.0 -0.04 1745280.0 61900.0 0.27 1594140.0 -132464.375 -0.690446492719242 1578040.0 79228.125 0.38200716111205 -0.0389 -0.0465 2125592 Peakdale2_000257 C1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L16 compound treatment 1023810.0 -562000.0 -2.75 1114470.0 -569000.0 -2.52 1288720.0 -437884.375 -2.28239276360385 1277850.0 -220961.875 -1.06539210138755 -4.31 -0.9574 2125593 Peakdale2_000258 C1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L17 compound treatment 1685600.0 100000.0 0.49 1818580.0 135000.0 0.6 1550050.0 -176554.375 -0.920257608832471 1326090.0 -172721.875 -0.832797609822274 -0.3321 -0.2271 2125594 Peakdale2_000259 CN(C)CCNc1cc(nc(C)n1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L18 compound treatment 1486450.0 -99200.0 -0.49 1639240.0 -44200.0 -0.2 1710510.0 -16094.375 -0.0838890061668146 1550410.0 51598.125 0.248786062398355 -0.2581 -0.4408 2125595 Peakdale2_000260 Cc1nc(NCCC#N)cc(n1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L19 compound treatment 1696880.0 111000.0 0.54 1556970.0 -126000.0 -0.56 1746020.0 19415.625 0.101200418491402 1303630.0 -195181.875 -0.941090982138944 -0.428 -0.3487 2125596 Peakdale2_000261 Cc1nc(NCC=C)cc(n1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L20 compound treatment 1163390.0 -422000.0 -2.07 1376450.0 -307000.0 -1.36 1440530.0 -286074.375 -1.49111071467781 1222560.0 -276251.875 -1.33197894713059 -3.1252 -0.9824 2125597 Peakdale2_000262 CN(Cc1ccccc1)c2cc(nc(C)n2)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L21 compound treatment 1488110.0 -97500.0 -0.48 1733030.0 49600.0 0.22 1662050.0 -64554.375 -0.336477953475662 1455870.0 -42941.875 -0.207048996320164 -0.4003 -0.6089 2125598 Peakdale2_000263 Cc1nc(NC2CCCCC2)cc(n1)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L22 compound treatment 1408450.0 -177000.0 -0.87 1706970.0 23600.0 0.1 1416590.0 -310014.375 -1.61589361601033 1216110.0 -282701.875 -1.36307833499535 -1.8707 -0.8179 2125599 Peakdale2_000264 Cc1nc(NCCc2ccccc2)cc(n1)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L23 mock treatment 1413280.0 -172000.0 -0.84 1783480.0 100000.0 0.44 1844040.0 117435.625 0.612111863295638 1633010.0 134198.125 0.647051091488156 0.4299 0.3296 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 L24 mock treatment 1710410.0 125000.0 0.61 1639880.0 -43500.0 -0.19 1765170.0 38565.625 0.201016314920714 1406410.0 -92401.875 -0.445525852721878 0.0866 0.1075 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M01 compound treatment 1410500.0 -175000.0 -0.86 1330500.0 -353000.0 -1.57 1387390.0 -339214.375 -1.76809331187121 1379200.0 -119611.875 -0.576721875016472 -2.3834 -0.9248 2125600 Peakdale2_000265 COCCNc1ncc(cn1)c2ccc(C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M02 compound treatment 1414330.0 -171000.0 -0.84 1526360.0 -157000.0 -0.7 1544380.0 -182224.375 -0.949811453884909 1446480.0 -52331.875 -0.25232391911863 -1.3683 -0.9325 2125601 Peakdale2_000266 Cc1nc(NCCc2c[nH]c3ccccc23)cc(n1)c4cncc(Br)c4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M03 compound treatment 1686040.0 100000.0 0.49 1582690.0 -101000.0 -0.45 1252380.0 -474224.375 -2.47180841249373 1544180.0 45368.125 0.218747428848362 -1.1041 -0.4298 2125602 Peakdale2_000267 CCN(CC)c1ncc(cn1)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M04 compound treatment 1573450.0 -12200.0 -0.06 1531530.0 -152000.0 -0.67 1457860.0 -268744.375 -1.40078123764804 1446650.0 -52161.875 -0.251504245329946 -1.1926 -0.7569 2125603 Peakdale2_000268 Fc1ccc(cc1)c2cnc(NCc3ccncc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M05 compound treatment 1543960.0 -41600.0 -0.2 1629860.0 -53500.0 -0.24 1365220.0 -361384.375 -1.88365040972175 1434240.0 -64571.875 -0.311340431903849 -1.3181 -0.6813 2125604 Peakdale2_000269 C1CN(CCO1)c2ncc(cn2)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M06 compound treatment 1723520.0 138000.0 0.67 1572800.0 -111000.0 -0.49 1419840.0 -306764.375 -1.59895358136827 1480660.0 -18151.875 -0.0875212714880075 -0.751 -0.4159 2125605 Peakdale2_000270 Fc1ccc(cc1)c2cnc(NCc3ccccc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M07 compound treatment 1543200.0 -42400.0 -0.21 1641040.0 -42400.0 -0.19 1268960.0 -457644.375 -2.38538817422752 1353390.0 -145421.875 -0.70116764258073 -1.741 -0.6958 2125606 Peakdale2_000271 OCCCNc1ncc(cn1)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M08 compound treatment 1649890.0 64300.0 0.31 1663360.0 -20000.0 -0.09 1545660.0 -180944.375 -0.943139686395117 1610840.0 112028.125 0.54015598622277 -0.0886 -0.0781 2125607 Peakdale2_000272 C1CN(CCN1c2ccccn2)c3ncc(cn3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M09 compound treatment 1652960.0 67400.0 0.33 1722760.0 39400.0 0.17 1605440.0 -121164.375 -0.631547295348421 1575480.0 76668.125 0.369663838176579 0.1211 0.1475 2125608 Peakdale2_000273 COc1ccc(cc1)c2cnc(nc2)N3CCC(O)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M10 compound treatment 1726430.0 141000.0 0.69 1631460.0 -51900.0 -0.23 1482650.0 -243954.375 -1.27156786571684 1415040.0 -83771.875 -0.40391535391988 -0.6084 -0.4004 2125609 Peakdale2_000274 CCN(CC)c1cc(nc(C)n1)c2cncc(c2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M11 compound treatment 1722460.0 137000.0 0.67 1679630.0 -3770.0 -0.02 1543440.0 -183164.375 -0.954711033135225 1661370.0 162558.125 0.783791965882668 0.241 0.1715 2125610 Peakdale2_000275 Clc1ccc(cc1)c2cnc(NCc3ccco3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M12 compound treatment 1652440.0 66800.0 0.33 1679330.0 -4070.0 -0.02 1667680.0 -58924.375 -0.30713260115728 1449030.0 -49781.875 -0.240028812288375 -0.1191 -0.2339 2125611 Peakdale2_000276 Cc1ccc(cc1)c2cncc(c2)c3cc(nc(C)n3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M13 compound treatment 1682920.0 97300.0 0.48 1582580.0 -101000.0 -0.45 1374960.0 -351644.375 -1.83288242897911 1559940.0 61128.125 0.294736010669854 -0.7545 -0.3834 2125612 Peakdale2_000277 Cc1ccc(cc1)c2cnc(nc2)N3CCN(CC3)c4ccccn4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M14 compound treatment 1757640.0 172000.0 0.84 1753310.0 69900.0 0.31 1771840.0 45235.625 0.235782478324552 1548260.0 49448.125 0.238419599776769 0.813 0.8489 2125613 Peakdale2_000278 CN(Cc1ccccc1)c2cc(nc(C)n2)c3cncc(c3)c4ccc(C)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M15 compound treatment 1624110.0 38500.0 0.19 1597060.0 -86300.0 -0.38 1783740.0 57135.625 0.297809066706213 1463680.0 -35131.875 -0.169392218145935 -0.033 -0.0604 2125614 Peakdale2_000279 Clc1ccc(cc1)c2cnc(NC3CCCCC3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M16 compound treatment 1576580.0 -9020.0 -0.04 1598810.0 -84600.0 -0.38 1679210.0 -47394.375 -0.247034570565637 1440990.0 -57821.875 -0.278794560882588 -0.4726 -0.8908 2125615 Peakdale2_000280 CN1CCN(CC1)c2cc(nc(C)n2)c3cncc(c3)c4ccc(C)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M17 compound treatment 1753970.0 168000.0 0.82 1848160.0 165000.0 0.73 1772130.0 45525.625 0.237294050646458 1595480.0 96668.125 0.466096048609945 1.129 0.9261 2125616 Peakdale2_000281 Clc1ccc(cc1)c2cnc(NCCc3c[nH]c4ccccc34)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M18 compound treatment 1322340.0 -263000.0 -1.29 1490030.0 -193000.0 -0.86 1168070.0 -558534.375 -2.91125897270027 1069300.0 -429511.875 -2.07093897568147 -3.564 -0.9154 2125617 Peakdale2_000282 Cc1nc(NCc2ccccc2)cc(n1)c3cncc(c3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M19 compound treatment 1672070.0 86500.0 0.42 1757000.0 73600.0 0.33 1699520.0 -27084.375 -0.141172384848701 1549230.0 50418.125 0.243096561982787 0.4257 0.705 2125618 Peakdale2_000283 Cn1cc(cn1)c2ccccc2NC(=O)/C=C/c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M20 compound treatment 1272740.0 -313000.0 -1.53 1345830.0 -338000.0 -1.5 1535950.0 -190654.375 -0.993751297587212 1431890.0 -66921.875 -0.32267121662977 -2.1722 -0.9117 2125619 Peakdale2_000284 CC(Nc1cc(nc(C)n1)c2cncc(c2)c3cccs3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M21 compound treatment 890100.0 -696000.0 -3.4 1742020.0 58600.0 0.26 1591200.0 -135404.375 -0.705770708672358 1594560.0 95748.125 0.46166016693001 -1.6938 -0.4817 2125620 Peakdale2_000285 Cn1cc(cn1)c2ccccc2NC(=O)Nc3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M22 compound treatment 1335810.0 -250000.0 -1.22 1206130.0 -477000.0 -2.12 1352000.0 -374604.375 -1.95255725832726 1190580.0 -308231.875 -1.48617405161354 -3.3888 -0.9785 2125621 Peakdale2_000286 COc1ccc(cc1)c2cncc(c2)c3cc(NC4CC4)nc(C)n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M23 mock treatment 1513440.0 -72200.0 -0.35 1736350.0 52900.0 0.23 1677600.0 -49004.375 -0.255426403111391 1578160.0 79348.125 0.38258575437465 0.0044 0.0071 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 M24 mock treatment 1600250.0 14600.0 0.07 1482270.0 -201000.0 -0.89 1659840.0 -66764.375 -0.347997177032256 1441670.0 -57141.875 -0.275515865727854 -0.7219 -0.7227 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N01 compound treatment 1442900.0 -143000.0 -0.7 1548320.0 -135000.0 -0.6 1547870.0 -178734.375 -0.931620462838523 1378640.0 -120171.875 -0.579421976908606 -1.4042 -0.9807 2125622 Peakdale2_000287 Cn1cc(cn1)c2cnccn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N02 compound treatment 1385690.0 -200000.0 -0.98 1423570.0 -260000.0 -1.15 1333090.0 -393514.375 -2.05112219835223 1483950.0 -14861.875 -0.0716581728717189 -2.1267 -0.8343 2125623 Peakdale2_000288 C(Nc1cc(nc(n1)c2ccccc2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N03 compound treatment 1424830.0 -161000.0 -0.79 1585700.0 -97700.0 -0.43 1518880.0 -207724.375 -1.08272557184561 1376710.0 -122101.875 -0.588727685215426 -1.4457 -0.948 2125624 Peakdale2_000289 Cn1cc(cn1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N04 compound treatment 1358030.0 -228000.0 -1.11 1371740.0 -312000.0 -1.38 1259200.0 -467404.375 -2.43626040133718 1319360.0 -179451.875 -0.865247048633102 -2.8986 -0.9243 2125625 Peakdale2_000290 C=CCNc1cc(nc(n1)c2cccnc2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N05 compound treatment 1700000.0 114000.0 0.56 1653330.0 -30100.0 -0.13 1671250.0 -55354.375 -0.288524624642782 1656480.0 157668.125 0.760214290431711 0.4491 0.4508 2125626 Peakdale2_000291 Cn1cc(cn1)c2ccc(cn2)C(=O)NCc3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N06 compound treatment 954410.0 -631000.0 -3.09 843110.0 -840000.0 -3.73 818720.0 -907884.375 -4.73218238876189 950100.0 -548711.875 -2.64567494986433 -7.0965 -0.9764 2125627 Peakdale2_000292 C(Nc1cc(nc(n1)c2ccncc2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N07 compound treatment 1566130.0 -19500.0 -0.1 1645990.0 -37400.0 -0.17 1477460.0 -249144.375 -1.2986197979606 1536000.0 37188.125 0.179306654781115 -0.6903 -0.521 2125628 Peakdale2_000293 Clc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N08 compound treatment 1289480.0 -296000.0 -1.45 1298560.0 -385000.0 -1.71 1092760.0 -633844.375 -3.30379866774421 1247040.0 -251771.875 -1.21394592156015 -3.8367 -0.9198 2125629 Peakdale2_000294 Cc1nc(cc(n1)c2ccncc2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N09 compound treatment 1596910.0 11300.0 0.06 1753960.0 70600.0 0.31 1453600.0 -273004.375 -1.42298571382501 1565010.0 66198.125 0.319181576014712 -0.3678 -0.2464 2125630 Peakdale2_000295 Fc1ccc(c(F)c1)n2cc(cn2)c3ccc(cn3)C(=O)NCC=C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N10 compound treatment 1457560.0 -128000.0 -0.63 1611360.0 -72000.0 -0.32 1440640.0 -285964.375 -1.49053735965915 1476350.0 -22461.875 -0.108302412836398 -1.2725 -0.7704 2125631 Peakdale2_000296 CC(Nc1cc(nc(C)n1)c2ccncc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N11 compound treatment 1761760.0 176000.0 0.86 1683370.0 -33.1 0.0 1661280.0 -65324.375 -0.34049143860624 1722480.0 223668.125 1.07844058486182 0.7999 0.5625 2124205 Peakdale2_000297 CCN1Cc2ccccc2-n3cccc3C1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N12 compound treatment 1611060.0 25500.0 0.12 1665300.0 -18100.0 -0.08 1577130.0 -149474.375 -0.779108027876557 1590890.0 92078.125 0.443964856315488 -0.1454 -0.16 2125632 Peakdale2_000298 CN(Cc1ccccc1)c2cc(nc(n2)c3ccccc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N13 compound treatment 1125920.0 -460000.0 -2.25 1330530.0 -353000.0 -1.56 1456590.0 -270014.375 -1.40740088195432 1151400.0 -347411.875 -1.67508475185251 -3.4484 -0.9834 2125633 Peakdale2_000299 C=CCNc1cc(nc(n1)c2cccnc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N14 compound treatment 1268320.0 -317000.0 -1.55 1302960.0 -380000.0 -1.69 1374830.0 -351774.375 -1.83356003036479 1419640.0 -79171.875 -0.381735945520206 -2.7275 -0.9213 2125634 Peakdale2_000300 C1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N15 compound treatment 1408710.0 -177000.0 -0.87 1490900.0 -193000.0 -0.85 1555890.0 -170714.375 -0.889817669660294 1555240.0 56428.125 0.272074441218013 -1.1685 -0.7633 2125635 Peakdale2_000301 CN(Cc1ccccc1)c2cc(nc(n2)c3ccncc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N16 compound treatment 673070.0 -913000.0 -4.47 924030.0 -759000.0 -3.37 1022750.0 -703854.375 -3.66871307552573 924320.0 -574491.875 -2.76997606911294 -7.1359 -0.9857 2125636 Peakdale2_000302 CN(Cc1ccccc1)c2cc(nc(n2)c3ccncc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N17 compound treatment 1708320.0 123000.0 0.6 1824480.0 141000.0 0.63 1730110.0 3505.625 0.0182724335206269 1562720.0 63908.125 0.308140087920092 0.7763 0.8433 2125637 Peakdale2_000303 COCCNc1cc(nc(C)n1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N18 compound treatment 1581400.0 -4200.0 -0.02 1651790.0 -31600.0 -0.14 1389020.0 -337584.375 -1.75959723295843 1413560.0 -85251.875 -0.41105133749195 -1.1657 -0.6431 2125638 Peakdale2_000304 Cc1cnc(CNc2cc(nc(C)n2)c3ccc(F)cc3)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N19 compound treatment 1753880.0 168000.0 0.82 1860220.0 177000.0 0.78 1794530.0 67925.625 0.35404998171782 1660960.0 162148.125 0.781815105568784 1.3717 0.9629 2125639 Peakdale2_000305 CN1CCN(CC1)c2cc(nc(C)n2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N20 compound treatment 1580740.0 -4860.0 -0.02 1712570.0 29200.0 0.13 1678330.0 -48274.375 -0.251621410714869 1562720.0 63908.125 0.308140087920092 0.081 0.1934 2125640 Peakdale2_000306 Cc1nc(NCCCO)cc(n1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N21 compound treatment 1476970.0 -109000.0 -0.53 1615040.0 -68400.0 -0.3 1695620.0 -30984.375 -0.161500426419162 1448870.0 -49941.875 -0.240800269971842 -0.6185 -0.9134 2125641 Peakdale2_000307 Cc1nc(NC2CC2)cc(n1)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N22 compound treatment 1292430.0 -293000.0 -1.43 1401280.0 -282000.0 -1.25 1213440.0 -513164.375 -2.67477608909725 1458880.0 -39931.875 -0.192535948649943 -2.7765 -0.8443 2125642 Peakdale2_000308 Cc1nc(cc(n1)c2ccc(F)cc2)N3CCN(CC3)c4ccccn4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N23 mock treatment 1694030.0 108000.0 0.53 1759920.0 76500.0 0.34 1746460.0 19855.625 0.103493838566018 1666480.0 167668.125 0.808430395648393 0.8909 0.865 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 N24 mock treatment 1560860.0 -24700.0 -0.12 1613530.0 -69900.0 -0.31 1631380.0 -95224.375 -0.496339757313103 1402280.0 -96531.875 -0.465439104176368 -0.6964 -0.9194 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O01 compound treatment 1023540.0 -562000.0 -2.75 1352500.0 -331000.0 -1.47 1359390.0 -367214.375 -1.91403822571041 1406100.0 -92711.875 -0.447020551983595 -3.2895 -0.8926 2125643 Peakdale2_000309 COCCNc1ncc(cn1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O02 compound treatment 1548440.0 -37200.0 -0.18 1647570.0 -35800.0 -0.16 1643360.0 -83244.375 -0.43389618346333 1639390.0 140578.125 0.6778129666164 -0.0484 -0.0576 2123203 Peakdale2_000310 CN1CCN(CC1)C2c3cccn3-c4ccccc24 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O03 compound treatment 1257810.0 -328000.0 -1.6 1227880.0 -456000.0 -2.02 1222650.0 -503954.375 -2.62677063708086 1201070.0 -297741.875 -1.43559535724124 -3.8433 -0.9726 2125644 Peakdale2_000311 Cc1ccc(cc1)c2cnc(NCc3ccncc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O04 compound treatment 1430400.0 -155000.0 -0.76 1335850.0 -348000.0 -1.54 1264690.0 -461914.375 -2.407644773588 1428700.0 -70111.875 -0.338052154193892 -2.5232 -0.8475 2125645 Peakdale2_000312 C(Nc1ncc(cn1)c2ccccc2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O05 compound treatment 1607520.0 21900.0 0.11 1679590.0 -3810.0 -0.02 1593070.0 -133534.375 -0.69602367335524 1609440.0 110628.125 0.533405731492434 -0.0361 -0.0409 2125646 Peakdale2_000313 Cc1ccc(cc1)c2cnc(nc2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O06 compound treatment 1456480.0 -129000.0 -0.63 1573400.0 -110000.0 -0.49 1344320.0 -382284.375 -1.99258786326601 1361630.0 -137181.875 -0.661437571882184 -1.8869 -0.84 2125647 Peakdale2_000314 C(Nc1ncc(cn1)c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O07 compound treatment 1019430.0 -566000.0 -2.77 819620.0 -864000.0 -3.83 910880.0 -815724.375 -4.25181512949686 922780.0 -576031.875 -2.77740134931631 -6.8152 -0.9822 2125648 Peakdale2_000315 OCCCNc1ncc(cn1)c2cc3ccccc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O08 compound treatment 1545570.0 -40000.0 -0.2 1579160.0 -104000.0 -0.46 1351520.0 -375084.375 -1.95505917113593 1592030.0 93218.125 0.44946149231019 -1.0819 -0.5232 2125649 Peakdale2_000316 Fc1ccc(cc1)c2cnc(NCc3ccc(Cl)cc3)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O09 compound treatment 1499780.0 -85800.0 -0.42 1787140.0 104000.0 0.46 1629610.0 -96994.375 -0.505565560795081 1716160.0 217348.125 1.04796800636487 0.2912 0.2207 2125650 Peakdale2_000317 OC1CCN(CC1)c2ncc(cn2)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O10 compound treatment 1702510.0 117000.0 0.57 1714340.0 30900.0 0.14 1629870.0 -96734.375 -0.504210358023717 1622630.0 123818.125 0.597002774273239 0.401 0.41 2125651 Peakdale2_000318 CCN(CC)c1cc(nc(C)n1)c2cncc(c2)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O11 compound treatment 1377500.0 -208000.0 -1.02 1311080.0 -372000.0 -1.65 1223200.0 -503404.375 -2.62390386198759 1683680.0 184868.125 0.891362096621088 -2.201 -0.6507 2125652 Peakdale2_000319 C(Nc1ncc(cn1)c2cccs2)c3ccco3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O12 compound treatment 1519680.0 -65900.0 -0.32 1616640.0 -66800.0 -0.3 1532350.0 -194254.375 -1.01251564365225 1541350.0 42538.125 0.205102271072041 -0.713 -0.6355 2125653 Peakdale2_000320 Cc1nc(cc(n1)c2cncc(c2)c3cccs3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O13 compound treatment 1373960.0 -212000.0 -1.04 1610290.0 -73100.0 -0.32 1356480.0 -370124.375 -1.92920607211298 1541320.0 42508.125 0.204957622756391 -1.5421 -0.6937 2125654 Peakdale2_000321 CC(Nc1ncc(cn1)c2ccc(C)cc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O14 compound treatment 1569920.0 -15700.0 -0.08 1503950.0 -179000.0 -0.8 1440480.0 -286124.375 -1.49137133059538 1569640.0 70828.125 0.341505632730037 -1.0112 -0.5858 2125655 Peakdale2_000322 CN(Cc1ccccc1)c2cc(nc(C)n2)c3cncc(c3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O15 compound treatment 1428340.0 -157000.0 -0.77 1764710.0 81300.0 0.36 1641080.0 -85524.375 -0.445780269304522 1457410.0 -41401.875 -0.199623716116795 -0.5272 -0.5378 2125656 Peakdale2_000323 C1CCC(CC1)Nc2ncc(cn2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O16 compound treatment 1552890.0 -32700.0 -0.16 1680320.0 -3080.0 -0.01 1600710.0 -125894.375 -0.656201561150543 1466310.0 -32501.875 -0.156711382473947 -0.4933 -0.7113 2125657 Peakdale2_000324 CN1CCN(CC1)c2cc(nc(C)n2)c3cncc(c3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O17 compound treatment 1645470.0 59900.0 0.29 1847360.0 164000.0 0.73 1661690.0 -64914.375 -0.338354388082166 1550770.0 51958.125 0.250521842186156 0.4661 0.5238 2125658 Peakdale2_000325 CCNC(=O)Nc1ccccc1c2cnn(c2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O18 compound treatment 1604850.0 19200.0 0.09 1679050.0 -4350.0 -0.02 1604980.0 -121624.375 -0.633944961790065 1484600.0 -14211.875 -0.0685241260326345 -0.3138 -0.4866 2125659 Peakdale2_000326 Cc1nc(NCc2ccccc2)cc(n1)c3cncc(c3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O19 compound treatment 1553790.0 -31800.0 -0.16 1632380.0 -51000.0 -0.23 1649280.0 -77324.375 -0.403039258823041 1491880.0 -6931.875 -0.0334228014348893 -0.4092 -0.837 2125660 Peakdale2_000327 Cn1cc(cn1)c2ccccc2NC(=O)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O20 compound treatment 1519480.0 -66100.0 -0.32 1665120.0 -18300.0 -0.08 1584750.0 -141854.375 -0.739390162038888 1412270.0 -86541.875 -0.417271215064902 -0.7807 -0.8558 2125661 Peakdale2_000328 CC(Nc1cc(nc(C)n1)c2cncc(c2)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O21 compound treatment 1607760.0 22200.0 0.11 1746680.0 63300.0 0.28 1754330.0 27725.625 0.144514783991537 1626000.0 127188.125 0.613251601731261 0.5734 0.8213 2125662 Peakdale2_000329 Cc1cc(C)cc(NC(=O)Nc2ccccc2c3cnn(C)c3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O22 compound treatment 660990.0 -925000.0 -4.52 720690.0 -963000.0 -4.27 676890.0 -1049714.375 -5.47144550054096 680640.0 -818171.875 -3.94490612103307 -9.1051 -0.9923 2125663 Peakdale2_000330 Cc1nc(NC2CC2)cc(n1)c3cncc(c3)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O23 mock treatment 1712560.0 127000.0 0.62 1661280.0 -22100.0 -0.1 1776330.0 49725.625 0.259185787722338 1572930.0 74118.125 0.357368731346325 0.5698 0.7416 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 O24 mock treatment 1517960.0 -67600.0 -0.33 1416250.0 -267000.0 -1.18 1608910.0 -117694.375 -0.613460550669062 1381150.0 -117661.875 -0.567319734499219 -1.3483 -0.9067 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P01 compound treatment 990470.0 -595000.0 -2.91 1278240.0 -405000.0 -1.8 1308210.0 -418394.375 -2.18080467893507 1286400.0 -212411.875 -1.02416733142729 -3.957 -0.9455 2125664 Peakdale2_000331 COc1ccc(cc1)c2cnn(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P02 compound treatment 1326510.0 -259000.0 -1.27 1489200.0 -194000.0 -0.86 1481130.0 -245474.375 -1.27949058961096 1445460.0 -53351.875 -0.257241961850731 -1.8329 -0.9105 2125665 Peakdale2_000332 C(Nc1cc(nc(n1)c2ccccc2)c3cccnc3)c4ccco4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P03 compound treatment 1288710.0 -297000.0 -1.45 1592980.0 -90400.0 -0.4 1558630.0 -167974.375 -0.875535917377458 1497120.0 -1691.875 -0.00815756230134753 -1.3688 -0.7853 2125666 Peakdale2_000333 OCCn1cc(cn1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P04 compound treatment 1005160.0 -580000.0 -2.84 1288210.0 -395000.0 -1.75 1109660.0 -616944.375 -3.21571048760555 1294080.0 -204731.875 -0.987137362620876 -4.3979 -0.9281 2125667 Peakdale2_000334 C(Nc1cc(nc(n1)c2cccnc2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P05 compound treatment 1530650.0 -55000.0 -0.27 1699240.0 15800.0 0.07 1697440.0 -29164.375 -0.152014007019614 1624650.0 125838.125 0.606742427527009 0.128 0.187 2125668 Peakdale2_000335 Cn1cc(cn1)c2ccc(cn2)C(=O)NC3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P06 compound treatment 1014300.0 -571000.0 -2.8 1023490.0 -660000.0 -2.93 1114090.0 -612514.375 -3.19261991730885 1196030.0 -302781.875 -1.45989627427045 -5.1873 -0.9682 2125669 Peakdale2_000336 CC(Nc1cc(nc(n1)c2ccncc2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P07 compound treatment 1702260.0 117000.0 0.57 1623240.0 -60200.0 -0.27 1403610.0 -322994.375 -1.6835495082115 1488320.0 -10491.875 -0.0505877348920284 -0.715 -0.3976 2125670 Peakdale2_000337 Clc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)NCc4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P08 compound treatment 1590990.0 5390.0 0.03 1620120.0 -63300.0 -0.28 1615640.0 -110964.375 -0.57838164816414 1507460.0 8648.125 0.0416978904927025 -0.3955 -0.6134 2125671 Peakdale2_000338 Cc1nc(NCCCO)cc(n1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P09 compound treatment 1476380.0 -109000.0 -0.53 1765340.0 81900.0 0.36 1788760.0 62155.625 0.323974904830241 1710800.0 211988.125 1.02212417396873 0.5875 0.4693 2125672 Peakdale2_000339 CN(Cc1ccccc1)C(=O)c2ccc(nc2)c3cnn(c3)c4ccc(C)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P10 compound treatment 1576050.0 -9550.0 -0.05 1546100.0 -137000.0 -0.61 1638930.0 -87674.375 -0.456986753760032 1565970.0 67158.125 0.323810322115514 -0.3944 -0.476 2125673 Peakdale2_000340 Cc1nc(NCc2ccc(Cl)cc2)cc(n1)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P11 compound treatment 985870.0 -600000.0 -2.93 825630.0 -858000.0 -3.8 821150.0 -905454.375 -4.71951645516799 1057190.0 -441621.875 -2.12932867909888 -6.7938 -0.9618 2125674 Peakdale2_000341 Brc1ccc(cc1)n2cc(cn2)c3ccc(cn3)C(=O)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P12 compound treatment 1133880.0 -452000.0 -2.21 1344010.0 -339000.0 -1.51 1311680.0 -414924.375 -2.16271793425571 1199240.0 -299571.875 -1.4444189044959 -3.6614 -0.9815 2125675 Peakdale2_000342 C=CCNc1cc(nc(n1)c2ccccc2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P13 compound treatment 767640.0 -818000.0 -4.0 830010.0 -853000.0 -3.78 962720.0 -763884.375 -3.98160854616028 991770.0 -507041.875 -2.44475843942642 -7.1068 -0.9839 2125676 Peakdale2_000343 CN1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P14 compound treatment 1445170.0 -140000.0 -0.69 1529810.0 -154000.0 -0.68 1574490.0 -152114.375 -0.792868548324253 1555460.0 56648.125 0.27313519553278 -0.944 -0.7373 2125677 Peakdale2_000344 CN(Cc1ccccc1)c2cc(nc(n2)c3cccnc3)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P15 compound treatment 922510.0 -663000.0 -3.24 1240600.0 -443000.0 -1.96 1206170.0 -520434.375 -2.71266964351193 1013490.0 -485321.875 -2.34003305889578 -5.1306 -0.9834 2125678 Peakdale2_000345 C=CCNc1cc(nc(n1)c2ccncc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P16 compound treatment 491930.0 -1090000.0 -5.35 477870.0 -1210000.0 -5.35 683680.0 -1042924.375 -5.43605385893495 279120.0 -1219691.875 -5.88087917769332 -11.0075 -0.9992 2125679 Peakdale2_000346 C=CCNc1cc(nc(n1)c2ccncc2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P17 compound treatment 1607840.0 22200.0 0.11 1626760.0 -56600.0 -0.25 1610790.0 -115814.375 -0.60366139216843 1641880.0 143068.125 0.689818776815354 -0.0281 -0.0294 2125680 Peakdale2_000347 CCN(CC)c1cc(nc(C)n1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P18 compound treatment 1185470.0 -400000.0 -1.96 1698680.0 15300.0 0.07 1705210.0 -21394.375 -0.111514293429235 1590780.0 91968.125 0.443434479158104 -0.7792 -0.3873 2125681 Peakdale2_000348 COCCNc1cc(nc(C)n1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P19 compound treatment 1670880.0 85300.0 0.42 1811560.0 128000.0 0.57 1844660.0 118055.625 0.615343500673506 1627090.0 128278.125 0.61850715719988 1.1097 0.9893 2125682 Peakdale2_000349 Cc1nc(cc(n1)c2cccnc2)N3CCC(O)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P20 compound treatment 1562510.0 -23100.0 -0.11 1549990.0 -133000.0 -0.59 1629860.0 -96744.375 -0.504262481207231 1570850.0 72038.125 0.347339781461255 -0.4308 -0.5015 2125683 Peakdale2_000350 Cc1nc(NCC=C)cc(n1)c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P21 compound treatment 1455410.0 -130000.0 -0.64 1571940.0 -111000.0 -0.49 1576180.0 -150424.375 -0.784059730310387 1570460.0 71648.125 0.345459353357805 -0.785 -0.6672 2125684 Peakdale2_000351 CCN(CC)c1cc(nc(n1)c2ccccc2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P22 compound treatment 983880.0 -602000.0 -2.94 1142620.0 -541000.0 -2.4 1050440.0 -676164.375 -3.52438398037546 934680.0 -564131.875 -2.72002418410846 -5.7936 -0.9901 2125685 Peakdale2_000352 CC(Nc1cc(nc(C)n1)c2ccc(F)cc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P23 mock treatment 1620260.0 34700.0 0.17 1550150.0 -133000.0 -0.59 1591710.0 -134894.375 -0.703112426313144 1580990.0 82178.125 0.396230912150972 -0.3641 -0.3589 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1305 P24 mock treatment 1326290.0 -259000.0 -1.27 1629550.0 -53900.0 -0.24 1517660.0 -208944.375 -1.08908460023432 1456480.0 -42331.875 -0.204107813901947 -1.4005 -0.8231 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A01 compound treatment 1113620.0 -518000.0 -2.53 1118840.0 -478000.0 -2.12 1202510.0 -336023.01886792 -1.75145894773811 1224410.0 -301528.26923077 -1.45385187550351 -3.9293 -0.9795 2075074 MixCom4_000001 COc1ccc(CN2CCCN(Cc3ccc(OC)cc3)C2c4ccccc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A02 compound treatment 1460260.0 -171000.0 -0.84 1486680.0 -110000.0 -0.49 1410990.0 -127543.01886792 -0.664794817838225 1432530.0 -93408.2692307699 -0.450378293733904 -1.2204 -0.9698 2079852 MixCom4_000002 Cc1nc(NC2CCCCC2)cc(n1)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A03 compound treatment 1408040.0 -223000.0 -1.09 1357120.0 -240000.0 -1.06 1380930.0 -157603.01886792 -0.821477107481311 1429120.0 -96818.2692307699 -0.466819985612793 -1.722 -0.9601 2075075 MixCom4_000003 CN1CCN(CC1)c2ccc(CNC(=O)C3=Cc4ccccc4OC3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A04 compound treatment 1388020.0 -243000.0 -1.19 1463430.0 -134000.0 -0.59 1222890.0 -315643.01886792 -1.64523189973658 1514370.0 -11568.2692307699 -0.0557776886405719 -1.7416 -0.8232 2079853 MixCom4_000004 Fc1ccc(cc1)c2cc(NCc3ccccc3)nc(n2)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A05 compound treatment 1655110.0 24000.0 0.12 1640920.0 43900.0 0.19 1583090.0 44556.9811320801 0.232245170437728 1546440.0 20501.7307692301 0.0988513607893301 0.3215 0.9467 2075076 MixCom4_000005 OC(CN1CCN(CC1)c2c(Cl)cncc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A06 compound treatment 1434720.0 -196000.0 -0.96 1426200.0 -171000.0 -0.76 763840.0 -774693.01886792 -4.03794663894678 1456160.0 -69778.2692307699 -0.336443637106883 -3.0466 -0.7198 2079854 MixCom4_000006 Fc1ccc(cc1)c2cc(NCc3ccccc3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A07 compound treatment 1636450.0 5320.0 0.03 1506810.0 -90300.0 -0.4 1469080.0 -69453.0188679199 -0.362011244805395 1484560.0 -41378.2692307699 -0.199509898291503 -0.4679 -0.8123 2075077 MixCom4_000007 CCc1ccc(cc1)S(=O)(=O)NCc2ccc(cc2)N3CCN(C)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A08 compound treatment 1260860.0 -370000.0 -1.81 1464530.0 -133000.0 -0.59 835890.0 -702643.01886792 -3.66239910172841 1417600.0 -108338.26923077 -0.522364938822412 -3.2922 -0.7912 2079855 MixCom4_000008 Fc1ccc(cc1)c2cc(NCC=C)nc(n2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A09 compound treatment 1628210.0 -2920.0 -0.01 1576660.0 -20400.0 -0.09 1560720.0 22186.9811320801 0.115645608916908 1543760.0 17821.7307692301 0.0859294445912591 0.0484 0.2834 2075078 MixCom4_000009 CC(C)S(=O)(=O)NCc1ccc(cc1)N2CCN(C)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A10 compound treatment 1573670.0 -57500.0 -0.28 1556960.0 -40100.0 -0.18 1531590.0 -6943.01886791992 -0.036189224659376 1332650.0 -193288.26923077 -0.931960752638133 -0.7136 -0.7206 2079856 MixCom4_000010 Cc1cnc(CNc2cc(nc(C)n2)c3ccccc3F)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A11 compound treatment 1609760.0 -21400.0 -0.1 1584230.0 -12800.0 -0.06 1536480.0 -2053.01886791992 -0.0107009879210296 1411250.0 -114688.26923077 -0.552982165635006 -0.3626 -0.6409 2075079 MixCom4_000011 OC(CNCc1csc(n1)c2cccs2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A12 compound treatment 1546950.0 -84200.0 -0.41 1598250.0 1180.0 0.01 1453890.0 -84643.0188679199 -0.441186360563162 1544730.0 18791.7307692301 0.0906064067972773 -0.3786 -0.6203 2079857 MixCom4_000012 Cc1nc(NCCCO)cc(n1)c2ccccc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A13 compound treatment 1651170.0 20000.0 0.1 1597450.0 381.0 0.0 1545450.0 6916.98113208008 0.0360535076910291 1603360.0 77421.7307692301 0.373297431682689 0.2546 0.6567 2075080 MixCom4_000013 O=C(CN1C(=O)c2ccccc2C1=O)N3CCC(=CC3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A14 compound treatment 1576320.0 -54800.0 -0.27 1513980.0 -83100.0 -0.37 1480770.0 -57763.0188679199 -0.301079243277528 1442100.0 -83838.2692307699 -0.404235481041539 -0.671 -0.9874 2079858 MixCom4_000014 Cc1nc(cc(n1)c2ccccc2F)N3CCN(CC3)c4ccccn4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A15 compound treatment 1580840.0 -50300.0 -0.25 1600640.0 3570.0 0.02 1482640.0 -55893.0188679199 -0.29133220796041 1503040.0 -22898.2692307699 -0.110406535851074 -0.316 -0.7953 2075081 MixCom4_000015 COc1cc2CCN(Cc2cc1OC)S(=O)(=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A16 compound treatment 1526110.0 -105000.0 -0.51 1532340.0 -64700.0 -0.29 1570900.0 32366.9811320801 0.168707009734161 1546740.0 20801.7307692301 0.100297843945831 -0.266 -0.4286 2079859 MixCom4_000016 Fc1ccccc1c2cc(nc(n2)c3ccccc3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A17 compound treatment 1584190.0 -46900.0 -0.23 1488510.0 -109000.0 -0.48 1497380.0 -41153.0188679199 -0.214502635460773 1474590.0 -51348.2692307699 -0.247581355192536 -0.5866 -0.9371 2075082 MixCom4_000017 Cc1cc(c(C)s1)S(=O)(=O)Nc2ccc3N4CCCC4COc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A18 compound treatment 905300.0 -726000.0 -3.55 948730.0 -648000.0 -2.88 941040.0 -597493.01886792 -3.11432382707869 1123920.0 -402018.26923077 -1.93837551682595 -5.7398 -0.9795 2079860 MixCom4_000018 Fc1ccccc1c2cc(nc(n2)c3cccnc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A19 compound treatment 1543580.0 -87500.0 -0.43 1425060.0 -172000.0 -0.76 1574360.0 35826.9811320801 0.186741631230005 1502780.0 -23158.2692307699 -0.111660154586707 -0.5581 -0.619 2075083 MixCom4_000019 CN(C)/C=C/C(=O)c1sc(nc1C)c2c(Cl)cc(cc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A20 compound treatment 1399840.0 -231000.0 -1.13 1353250.0 -244000.0 -1.08 1418510.0 -120023.01886792 -0.625598183835697 1101970.0 -423968.26923077 -2.04420986777657 -2.4414 -0.9214 2079861 MixCom4_000020 Fc1ccccc1c2cc(NC3CC3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A21 compound treatment 1580360.0 -50800.0 -0.25 1633710.0 36600.0 0.16 1505160.0 -33373.0188679199 -0.17395079868688 1434290.0 -91648.2692307699 -0.441892259215768 -0.3509 -0.6265 2075084 MixCom4_000021 CN(C)/C(=N\O)/c1c(Cl)cccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A22 compound treatment 1312910.0 -318000.0 -1.56 1283140.0 -314000.0 -1.39 1373380.0 -165153.01886792 -0.860830111034382 1359360.0 -166578.26923077 -0.803175535604373 -2.3067 -0.962 2079862 MixCom4_000022 OC1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A23 mock treatment 1665320.0 34200.0 0.17 1482990.0 -114000.0 -0.51 1537630.0 -903.01886791992 -0.00470682181691952 1493390.0 -32548.2692307699 -0.156935077385173 -0.2501 -0.4502 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 A24 mock treatment 1555680.0 -75400.0 -0.37 1530130.0 -66900.0 -0.3 1493660.0 -44873.0188679199 -0.233892459727981 1468410.0 -57528.2692307699 -0.277378908216446 -0.5887 -0.9865 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B01 compound treatment 1163770.0 -467000.0 -2.29 1283880.0 -313000.0 -1.39 1267010.0 -271523.01886792 -1.41526441407281 1327250.0 -198688.26923077 -0.957997449455142 -3.0246 -0.9526 2079863 MixCom4_000023 Cc1nc(NCc2ccncc2)cc(n1)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B02 compound treatment 1572480.0 -58600.0 -0.29 1563120.0 -33900.0 -0.15 1459680.0 -78853.0188679199 -0.411007037308555 1565460.0 39521.7307692301 0.190558392911461 -0.329 -0.5906 2075085 MixCom4_000024 CN(C)/C=C/C(=O)c1c(C)onc1c2ccc(Cl)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B03 compound treatment 1470880.0 -160000.0 -0.78 1433440.0 -164000.0 -0.73 1282050.0 -256483.01886792 -1.33687114606775 1420420.0 -105518.26923077 -0.508767997151307 -1.6777 -0.9397 2079864 MixCom4_000025 Cc1nc(NCc2ccco2)cc(n1)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B04 compound treatment 1416830.0 -214000.0 -1.05 1465930.0 -131000.0 -0.58 1124010.0 -414523.01886792 -2.16062593832302 1436060.0 -89878.2692307699 -0.433358008592415 -2.1121 -0.8419 2075086 MixCom4_000026 NC(=O)C1=CN(Cc2c(Cl)cccc2Cl)CCC1C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B05 compound treatment 1651880.0 20800.0 0.1 1582640.0 -14400.0 -0.06 1393000.0 -145533.01886792 -0.758564424979913 1542340.0 16401.7307692301 0.0790827576504901 -0.321 -0.4157 2079865 MixCom4_000027 FC(F)(F)Oc1ccc(cc1)c2cnc(nc2)N3CCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B06 compound treatment 1689940.0 58800.0 0.29 1719780.0 123000.0 0.54 1692590.0 154056.98113208 0.802994029916036 1601500.0 75561.7307692301 0.364329236112386 0.9997 0.9296 1233106 MixCom4_000028 CN1CCN(CC1)c2ccc(NS(=O)(=O)c3ccc(Br)cc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B07 compound treatment 1722560.0 91400.0 0.45 1664510.0 67400.0 0.3 1510040.0 -28493.0188679199 -0.148514685132048 1622310.0 96371.7307692301 0.464666951068303 0.5313 0.7315 2079866 MixCom4_000029 CN(C)CCNc1ccc(cc1F)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B08 mock treatment 1639520.0 8390.0 0.04 1627200.0 30100.0 0.13 1434290.0 -104243.01886792 -0.543347800250603 1629370.0 103431.73076923 0.498707521351281 0.065 0.0866 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B09 compound treatment 1689700.0 58600.0 0.29 1596360.0 -709.0 0.0 1441280.0 -97253.0188679199 -0.506913694974317 1547420.0 21481.7307692301 0.103576539100565 -0.0599 -0.1013 2079867 MixCom4_000030 CS(=O)(=O)c1ccc(NCc2ccccc2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B10 mock treatment 1638520.0 7390.0 0.04 1632040.0 35000.0 0.16 1500760.0 -37773.0188679199 -0.19688499943304 1392050.0 -133888.26923077 -0.645557087651037 -0.3256 -0.4695 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B11 compound treatment 1545820.0 -85300.0 -0.42 1665220.0 68200.0 0.3 1399870.0 -138663.01886792 -0.722755797905794 1526150.0 211.730769230053 0.00102088330468054 -0.4185 -0.4714 2079868 MixCom4_000031 CS(=O)(=O)c1ccc(cc1)N2CCC3(CC2)OCCO3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B12 compound treatment 1556860.0 -74300.0 -0.36 1648170.0 51100.0 0.23 1393720.0 -144813.01886792 -0.754811555766905 1574510.0 48571.7307692301 0.234193968132559 -0.3287 -0.3657 2079908 MixCom4_000032 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)c4ccc(cc4)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B13 compound treatment 1735170.0 104000.0 0.51 1597510.0 441.0 0.0 1524870.0 -13663.0188679199 -0.0712160039807845 1628410.0 102471.73076923 0.49407877525048 0.467 0.6549 2079869 MixCom4_000033 CS(=O)(=O)c1ccc(NCCc2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B14 compound treatment 1666240.0 35100.0 0.17 1557220.0 -39800.0 -0.18 1567710.0 29176.9811320801 0.152079714193195 1615390.0 89451.7307692301 0.431301406258358 0.2892 0.5567 2079910 MixCom4_000034 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B15 compound treatment 1670500.0 39400.0 0.19 1571890.0 -25200.0 -0.11 1449220.0 -89313.0188679199 -0.4655278872642 1436640.0 -89298.2692307699 -0.430561474489848 -0.4075 -0.6064 2079870 MixCom4_000035 CS(=O)(=O)c1ccc(N2CCN(CC2)C(=O)c3ccccc3)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B16 compound treatment 1688260.0 57100.0 0.28 1573960.0 -23100.0 -0.1 1588740.0 50206.9811320801 0.261694769123138 1504440.0 -21498.2692307699 -0.103656281120738 0.1676 0.4089 2079915 MixCom4_000036 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B17 compound treatment 1746520.0 115000.0 0.56 1686410.0 89300.0 0.4 1614260.0 75726.9811320801 0.394713133450868 1513600.0 -12338.2692307699 -0.0594903287422564 0.648 0.8131 2079871 MixCom4_000037 CC(=O)N1CCCN(CC1)c2ccc(cc2F)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B18 compound treatment 1628010.0 -3120.0 -0.02 1564970.0 -32100.0 -0.14 1672480.0 133946.98113208 0.698174307869381 1493000.0 -32938.2692307699 -0.158815505488623 0.1909 0.2614 2079917 MixCom4_000038 CCCN1CCC(CC1)N(C(=O)c2cccs2)c3ccc4N(CCc4c3)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B19 compound treatment 1662620.0 31500.0 0.15 1624710.0 27600.0 0.12 1546730.0 8196.98113208008 0.0427252751808212 1604320.0 78381.7307692301 0.37792617778349 0.3487 0.8141 2079872 MixCom4_000039 O=C(C1CCCCC1)N2CCc3nc4ccccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B20 compound treatment 1403370.0 -228000.0 -1.11 1405120.0 -192000.0 -0.85 1413190.0 -125343.01886792 -0.653327717465145 1308990.0 -216948.26923077 -1.0460400575808 -1.8326 -0.9813 2079919 MixCom4_000040 COc1cccc(OC)c1CN2CCC(CC2)N(C(=O)c3cccc(c3)C(F)(F)F)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B21 compound treatment 1617600.0 -13500.0 -0.07 1521330.0 -75700.0 -0.34 1657920.0 119386.98113208 0.622282952672996 1521310.0 -4628.26923076995 -0.022315711620194 0.0989 0.1392 2079873 MixCom4_000041 CCC(=O)N1CCc2nc3ccccn3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B22 compound treatment 1670800.0 39700.0 0.19 1551910.0 -45200.0 -0.2 1691010.0 152476.98113208 0.794758566920824 1512590.0 -13348.2692307699 -0.0643601553691414 0.3621 0.4287 2079921 MixCom4_000042 OC(=O)C1N(Cc2ccccc2-n3cccc13)C4CCNCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B23 mock treatment 1704710.0 73600.0 0.36 1638500.0 41400.0 0.18 1624870.0 86336.9811320801 0.450015831159223 1602650.0 76711.7307692301 0.369874088212304 0.6818 0.9617 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 B24 mock treatment 1637280.0 6150.0 0.03 1593920.0 -3150.0 -0.01 1500600.0 -37933.0188679199 -0.197718970369264 1546100.0 20161.7307692301 0.0972120132119629 -0.0422 -0.1893 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C01 compound treatment 1213630.0 -417000.0 -2.04 1221660.0 -375000.0 -1.66 1151130.0 -387403.01886792 -2.01926786463305 1343480.0 -182458.26923077 -0.879742710688465 -3.3034 -0.9618 2075090 MixCom4_000043 COc1ccc(CN2CCCN(Cc3ccc(OC)cc3)C2c4cccc(Cl)c4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C02 compound treatment 1447550.0 -184000.0 -0.9 1443250.0 -154000.0 -0.68 1156410.0 -382123.01886792 -1.99174682373766 1466420.0 -59518.2692307699 -0.286973913154566 -1.9296 -0.8365 2079874 MixCom4_000044 Cc1nc(NC2CC2)cc(n1)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C03 compound treatment 1585190.0 -45900.0 -0.22 1445350.0 -152000.0 -0.67 1416670.0 -121863.01886792 -0.635188849602273 1574040.0 48101.7307692301 0.231927811187375 -0.6504 -0.6637 2075091 MixCom4_000045 CN1CCN(CC1)c2ccc(CNC(=O)C3CCC3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C04 compound treatment 1281210.0 -350000.0 -1.71 1339360.0 -258000.0 -1.14 1199520.0 -339013.01886792 -1.7670437796088 1200800.0 -325138.26923077 -1.5676900999201 -3.0949 -0.9877 2079875 MixCom4_000046 CCN(CC)c1cc(nc(n1)c2cccnc2)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C05 compound treatment 1557840.0 -73300.0 -0.36 1509490.0 -87600.0 -0.39 1344420.0 -194113.01886792 -1.01177885049093 1538720.0 12781.7307692301 0.0616285275620509 -0.8486 -0.7423 2075092 MixCom4_000047 CN1CCN(CC1)c2ccc(CNCC(O)C(F)(F)F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C06 compound treatment 1311070.0 -320000.0 -1.57 1361670.0 -235000.0 -1.04 1292020.0 -246513.01886792 -1.28490433210429 1351080.0 -174858.26923077 -0.843098470723786 -2.3691 -0.975 2079876 MixCom4_000048 Fc1ccc(cc1)c2cc(NCc3ccco3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C07 compound treatment 1658030.0 26900.0 0.13 1586970.0 -10100.0 -0.04 1575090.0 36556.9811320801 0.190546623626527 1512690.0 -13248.2692307699 -0.0638779943169746 0.1068 0.4369 2075093 MixCom4_000049 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3ccc(Cl)cc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C08 compound treatment 167920.0 -1460000.0 -7.16 334720.0 -1260000.0 -5.6 367400.0 -1171133.01886792 -6.10431812617583 1000050.0 -525888.26923077 -2.535628412145 -10.6991 -0.952 2079877 MixCom4_000050 CN1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C09 compound treatment 1706080.0 75000.0 0.37 1685370.0 88300.0 0.39 1553480.0 14946.9811320801 0.0779084240527717 1558760.0 32821.7307692301 0.158253602416283 0.4973 0.8804 2075094 MixCom4_000051 CN1CCN(CC1)c2ccc(CNS(=O)(=O)C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C10 compound treatment 1660450.0 29300.0 0.14 1452260.0 -145000.0 -0.64 1417370.0 -121163.01886792 -0.631540226756293 1558400.0 32461.7307692301 0.156517822628483 -0.4869 -0.5261 2079878 MixCom4_000052 COCCNc1cc(nc(C)n1)c2ccccc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C11 compound treatment 1670040.0 38900.0 0.19 1613060.0 16000.0 0.07 1572980.0 34446.9811320801 0.179548631905073 1598420.0 72481.7307692301 0.349478675705648 0.3952 0.8934 2075095 MixCom4_000053 Cc1cc(CNCC(O)C(F)(F)F)no1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C12 compound treatment 1573240.0 -57900.0 -0.28 1503110.0 -94000.0 -0.42 1522160.0 -16373.0188679199 -0.0853413867130787 1577440.0 51501.7307692301 0.248321286961047 -0.2685 -0.4725 2079879 MixCom4_000054 Cc1nc(NCC=C)cc(n1)c2ccccc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C13 compound treatment 1780080.0 149000.0 0.73 1705500.0 108000.0 0.48 1673560.0 135026.98113208 0.703803611688893 1590450.0 64511.7307692301 0.311050439847951 1.1123 0.9557 2075096 MixCom4_000055 O=C(C1CCCCN1)N2CCN(Cc3cccnc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C14 compound treatment 1651010.0 19900.0 0.1 1527300.0 -69800.0 -0.31 1348960.0 -189573.01886792 -0.988114925175572 1373440.0 -152498.26923077 -0.735287259459283 -0.9678 -0.7598 2079880 MixCom4_000056 CC(Nc1cc(nc(C)n1)c2ccccc2F)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C15 compound treatment 1662210.0 31100.0 0.15 1535420.0 -61600.0 -0.27 1502010.0 -36523.0188679199 -0.19036960149379 1555790.0 29851.7307692301 0.143933419166929 -0.0839 -0.2131 2075097 MixCom4_000057 COc1cc2CCN(Cc2cc1OC)S(=O)(=O)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C16 compound treatment 1634990.0 3860.0 0.02 1545160.0 -51900.0 -0.23 1560440.0 21906.9811320801 0.114186159778516 1431540.0 -94398.2692307699 -0.455151688150356 -0.2761 -0.528 2079881 MixCom4_000058 CN(Cc1ccccc1)c2cc(nc(n2)c3ccccc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C17 compound treatment 1469650.0 -161000.0 -0.79 1541460.0 -55600.0 -0.25 1492040.0 -46493.0188679199 -0.242336415457249 1348020.0 -177918.26923077 -0.857852598920091 -1.0685 -0.8783 1575275 MixCom4_000059 Fc1ccc(cc1)C2NCCc3c2[nH]c4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C18 compound treatment 1422840.0 -208000.0 -1.02 1582790.0 -14300.0 -0.06 1684130.0 145596.98113208 0.758897816663192 1465650.0 -60288.2692307699 -0.290686553256251 -0.3072 -0.2354 2079882 MixCom4_000060 Clc1ccc(cc1)c2cnc(nc2)N3CCN(Cc4ccccc4)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C19 compound treatment 1555680.0 -75400.0 -0.37 1567790.0 -29300.0 -0.13 1426790.0 -111743.01886792 -0.582440187886104 1451840.0 -74098.2692307699 -0.35727299456049 -0.7194 -0.9136 2075098 MixCom4_000061 CN(C)/C=C/C(=O)c1ccc(o1)c2cc(ccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C20 compound treatment 501730.0 -1130000.0 -5.53 1184210.0 -413000.0 -1.83 897060.0 -641473.01886792 -3.34356158817327 1216320.0 -309618.26923077 -1.4928587046238 -6.097 -0.8865 2079883 MixCom4_000062 CCN(CC)c1cc(nc(n1)c2ccncc2)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C21 compound treatment 1401850.0 -229000.0 -1.12 1276480.0 -321000.0 -1.42 1328980.0 -209553.01886792 -1.09225704583655 1085320.0 -440618.26923077 -2.12448968296235 -2.8802 -0.9608 2075099 MixCom4_000063 CSc1nc(nn1C(=O)N(C)C)c2ccc(cc2)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C22 compound treatment 1506950.0 -124000.0 -0.61 1408800.0 -188000.0 -0.83 1375770.0 -162763.01886792 -0.848372670174536 1284840.0 -241098.26923077 -1.16248195167909 -1.7267 -0.9748 2079884 MixCom4_000064 Fc1ccccc1c2cc(NCc3ccccc3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C23 mock treatment 1682110.0 51000.0 0.25 1534680.0 -62400.0 -0.28 1623400.0 84866.9811320801 0.442353723182665 1377140.0 -148798.26923077 -0.717447300529111 -0.1511 -0.164 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 C24 mock treatment 1679900.0 48800.0 0.24 1456030.0 -141000.0 -0.63 1532820.0 -5713.01886791992 -0.0297780730871539 1405160.0 -120778.26923077 -0.582345773711965 -0.4995 -0.5626 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D01 compound treatment 1385280.0 -246000.0 -1.2 1482480.0 -115000.0 -0.51 1459620.0 -78913.0188679199 -0.411319776409639 1457310.0 -68628.2692307699 -0.330898785006964 -1.2267 -0.8709 2079885 MixCom4_000065 Cc1nc(cc(n1)c2cccc(c2)C(F)(F)F)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D02 compound treatment 1417670.0 -213000.0 -1.04 1448750.0 -148000.0 -0.66 1372220.0 -166313.01886792 -0.866876400322006 1512480.0 -13458.2692307699 -0.0648905325265249 -1.317 -0.8723 2075087 MixCom4_000066 CN(C)/C=C/C(=O)c1cc(no1)c2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D03 compound treatment 1551130.0 -80000.0 -0.39 1515710.0 -81400.0 -0.36 1377280.0 -161253.01886792 -0.840502069463922 1635760.0 109821.73076923 0.529517612584741 -0.5316 -0.4717 2079886 MixCom4_000067 CC(Nc1cc(nc(C)n1)c2cccc(c2)C(F)(F)F)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D04 compound treatment 1385660.0 -245000.0 -1.2 1409720.0 -187000.0 -0.83 1425710.0 -112823.01886792 -0.588069491705616 1524860.0 -1078.26923076995 -0.00519899426827155 -1.3126 -0.8337 1384637 MixCom4_000068 Clc1ccc(cc1)C(=O)N2CCN(Cc3ccc4OCOc4c3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D05 compound treatment 1373250.0 -258000.0 -1.26 1410480.0 -187000.0 -0.83 1192040.0 -346493.01886792 -1.80603192087727 1467160.0 -58778.2692307699 -0.283405921368532 -2.0894 -0.8814 2079887 MixCom4_000069 C1CCN(C1)c2ncc(cn2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D06 compound treatment 1647540.0 16400.0 0.08 1736070.0 139000.0 0.62 1427490.0 -111043.01886792 -0.578791565040124 1610880.0 84941.7307692301 0.409555942805634 0.2638 0.2797 1669460 MixCom4_000070 CN1CCN(CC1)c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D07 compound treatment 1734600.0 103000.0 0.51 1597700.0 631.0 0.0 1508020.0 -30513.0188679199 -0.159043568201876 1423570.0 -102368.26923077 -0.493579924008052 -0.0717 -0.099 2079888 MixCom4_000071 Cc1cnc(CNc2ccc(cc2F)S(=O)(=O)C)cn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D08 mock treatment 1670960.0 39800.0 0.19 1664550.0 67500.0 0.3 1490920.0 -47613.0188679199 -0.248174212010817 1612390.0 86451.7307692301 0.416836574693354 0.3314 0.5502 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D09 compound treatment 1616210.0 -14900.0 -0.07 1588380.0 -8690.0 -0.04 1541330.0 2796.98113208008 0.0145787560832608 1433820.0 -92118.2692307699 -0.444158416160952 -0.2706 -0.5986 2079889 MixCom4_000072 CS(=O)(=O)c1ccc(NCc2ccco2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D10 mock treatment 1629660.0 -1470.0 -0.01 1766750.0 170000.0 0.75 1277890.0 -260643.01886792 -1.35855439040958 1430360.0 -95578.2692307699 -0.460841188565925 -0.537 -0.3315 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D11 compound treatment 1641150.0 10000.0 0.05 1666300.0 69200.0 0.31 1640800.0 102266.98113208 0.533048062497026 1565250.0 39311.7307692301 0.189545854701911 0.5393 0.8355 2079890 MixCom4_000073 CS(=O)(=O)c1ccc(NCc2cccnc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D12 compound treatment 1781190.0 150000.0 0.73 1698930.0 102000.0 0.45 1600540.0 62006.9811320801 0.323200125669659 1655650.0 129711.73076923 0.625419445860724 1.0673 0.9589 2079923 MixCom4_000074 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D13 compound treatment 1673940.0 42800.0 0.21 1768110.0 171000.0 0.76 1788250.0 249716.98113208 1.30160440341097 1564320.0 38381.7307692301 0.185061756916759 1.2273 0.801 2079891 MixCom4_000075 CS(=O)(=O)c1ccc(cc1)N2CCN(CC2)c3ccccn3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D14 compound treatment 1743700.0 113000.0 0.55 1723430.0 126000.0 0.56 1488000.0 -50533.0188679199 -0.263394181596905 1599280.0 73341.7307692301 0.353625260754282 0.6007 0.6667 2079925 MixCom4_000076 CC(=O)N1CCc2nc3cccc(C)n3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D15 compound treatment 1574420.0 -56700.0 -0.28 1567260.0 -29800.0 -0.13 1301040.0 -237493.01886792 -1.23788922057466 1588960.0 63021.7307692301 0.303866240170666 -0.6719 -0.5124 2079892 MixCom4_000077 CS(=O)(=O)c1ccc(N2CCN(CC2)C(=O)c3ccc(Cl)cc3)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D16 compound treatment 1698720.0 67600.0 0.33 1414800.0 -182000.0 -0.81 1654010.0 115476.98113208 0.601902787919021 1520000.0 -5938.26923076995 -0.0286320214035794 0.0479 0.0451 2079938 MixCom4_000078 CCCN(C1CCN(C)CC1)C(=O)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D17 compound treatment 1719120.0 88000.0 0.43 1727360.0 130000.0 0.58 1512330.0 -26203.0188679199 -0.136578476107341 1616230.0 90291.7307692301 0.43535155909656 0.6536 0.7663 2079893 MixCom4_000079 CS(=O)(=O)c1ccc(cc1)N2CCCNCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D18 compound treatment 1540820.0 -90300.0 -0.44 1372360.0 -225000.0 -1.0 1594910.0 56376.9811320801 0.293854773351277 1270240.0 -255698.26923077 -1.23287746529545 -1.1887 -0.7111 2079940 MixCom4_000080 CC(=O)N1CCc2cc(NC3CCN(Cc4ccccc4)CC3)ccc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D19 compound treatment 1671420.0 40300.0 0.2 1628250.0 31200.0 0.14 1624200.0 85666.9811320801 0.446523577863785 1405250.0 -120688.26923077 -0.581911828765015 0.1 0.1296 2079894 MixCom4_000081 Fc1cc(F)cc(CC(=O)N2CCc3nc4ccccn4c(=O)c3C2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D20 compound treatment 1651860.0 20700.0 0.1 1465240.0 -132000.0 -0.58 1578460.0 39926.9811320801 0.208112136470746 1247930.0 -278008.26923077 -1.34044759603387 -0.8078 -0.5456 2079944 MixCom4_000082 FC(F)(F)c1cccc(CNC(=O)c2ccc(CCN3CCCC3)nc2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D21 compound treatment 1703050.0 71900.0 0.35 1487950.0 -109000.0 -0.48 1449440.0 -89093.0188679199 -0.464381177226892 1269120.0 -256818.26923077 -1.23827766907972 -0.9173 -0.632 2079895 MixCom4_000083 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)c4cccc(c4)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D22 compound treatment 1735600.0 104000.0 0.51 1580960.0 -16100.0 -0.07 1600660.0 62126.9811320801 0.323825603871827 1299710.0 -226228.26923077 -1.09078460322189 -0.1636 -0.1309 2079946 MixCom4_000084 OC(=O)C1N(Cc2ccccc2)Cc3ccccc3-n4cccc14 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D23 mock treatment 1607630.0 -23500.0 -0.11 1529920.0 -67100.0 -0.3 1534990.0 -3543.01886791992 -0.0184673422646157 1253710.0 -272228.26923077 -1.31257868721863 -0.8719 -0.6454 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 D24 mock treatment 1657920.0 26800.0 0.13 1438080.0 -159000.0 -0.71 1647410.0 108876.98113208 0.567501486799781 1550360.0 24421.7307692301 0.11775207403427 0.0556 0.0603 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E01 compound treatment 1341820.0 -289000.0 -1.42 1320730.0 -276000.0 -1.23 1315060.0 -223473.01886792 -1.16481251728803 1333990.0 -191948.26923077 -0.925499794539097 -2.3658 -0.9892 2075103 MixCom4_000085 COc1ccc(CN2CCCN(Cc3ccc(OC)cc3)C2c4ccsc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E02 compound treatment 1117920.0 -513000.0 -2.51 1166560.0 -431000.0 -1.91 1077410.0 -461123.01886792 -2.40351997349826 1273560.0 -252378.26923077 -1.21686971836351 -4.0205 -0.9692 2079896 MixCom4_000086 Cc1nc(NCCc2c[nH]c3ccccc23)cc(n1)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E03 compound treatment 1467780.0 -163000.0 -0.8 1447050.0 -150000.0 -0.67 1272960.0 -265573.01886792 -1.38425111988198 1545120.0 19181.7307692301 0.0924868349007279 -1.3782 -0.7949 2075104 MixCom4_000087 CN1CCN(CC1)c2ccc(CNC(=O)C3CCCCC3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E04 compound treatment 1079640.0 -551000.0 -2.7 910760.0 -686000.0 -3.04 847430.0 -691103.01886792 -3.60224894795325 1024960.0 -500978.26923077 -2.41552209405025 -5.88 -0.9889 2079897 MixCom4_000088 Fc1ccc(cc1)c2cc(nc(n2)c3cccnc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E05 compound treatment 1507960.0 -123000.0 -0.6 1676980.0 79900.0 0.35 1329620.0 -208913.01886792 -1.08892116209165 1545490.0 19551.7307692301 0.0942708307937452 -0.6215 -0.479 2075105 MixCom4_000089 OC(CN1CCCN(CC1)c2nccc(n2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E06 compound treatment 1606500.0 -24600.0 -0.12 1516110.0 -81000.0 -0.36 1299840.0 -238693.01886792 -1.24414400259634 1507840.0 -18098.2692307699 -0.0872628053470658 -0.9055 -0.6947 2079898 MixCom4_000090 Fc1ccc(cc1)c2cc(NCc3ccc(Cl)cc3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E07 compound treatment 1658660.0 27500.0 0.13 1473890.0 -123000.0 -0.55 1412230.0 -126303.01886792 -0.658331543082489 1604280.0 78341.7307692301 0.377733313362624 -0.3461 -0.3663 2075106 MixCom4_000091 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3cc(F)ccc3C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E08 compound treatment 1423320.0 -208000.0 -1.02 1474690.0 -122000.0 -0.54 1271110.0 -267423.01886792 -1.39389390883207 1553180.0 27241.7307692301 0.131349015705374 -1.4111 -0.7781 2079899 MixCom4_000092 Fc1ccc(cc1)c2cc(NCc3ccccc3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E09 compound treatment 1670830.0 39700.0 0.19 1801710.0 205000.0 0.91 1543900.0 5366.98113208008 0.027974414246359 1716560.0 190621.73076923 0.919103742735539 1.0244 0.7841 2075107 MixCom4_000093 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3ccsc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E10 compound treatment 1626020.0 -5110.0 -0.02 1531210.0 -65900.0 -0.29 1463700.0 -74833.0188679199 -0.390053517535927 1550730.0 24791.7307692301 0.119536069927287 -0.2938 -0.5848 2079900 MixCom4_000094 Cc1nc(cc(n1)c2ccccc2F)N3CCC4(CC3)OCCO4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E11 compound treatment 1585670.0 -45500.0 -0.22 1709450.0 112000.0 0.5 1420000.0 -118533.01886792 -0.61783182949211 1678360.0 152421.73076923 0.73491822080781 0.1965 0.1779 2075108 MixCom4_000095 OC(CN1CCCN(Cc2ccc(F)cc2)CC1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E12 compound treatment 1720660.0 89500.0 0.44 1548440.0 -48600.0 -0.22 1362240.0 -176293.01886792 -0.918895337468979 1640390.0 114451.73076923 0.551841669300066 -0.0723 -0.0614 2079901 MixCom4_000096 CN1CCN(CC1)c2cc(nc(C)n2)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E13 compound treatment 1713670.0 82500.0 0.4 1575470.0 -21600.0 -0.1 1270750.0 -267783.01886792 -1.39577034343857 1614270.0 88331.7307692301 0.42590120247409 -0.3309 -0.2181 2075109 MixCom4_000097 Clc1c(sc2ccccc12)C(=O)N3CCN(Cc4cccnc4)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E14 compound treatment 1502560.0 -129000.0 -0.63 1675270.0 78200.0 0.35 1288180.0 -250353.01886792 -1.30491963457367 1508110.0 -17828.2692307699 -0.0859609705062153 -0.8366 -0.5607 2079902 MixCom4_000098 Cc1nc(NC2CCCCC2)cc(n1)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E15 compound treatment 1673770.0 42600.0 0.21 1706370.0 109000.0 0.48 1354560.0 -183973.01886792 -0.958925942407731 1602720.0 76781.7307692301 0.370211600948821 0.0523 0.0453 2075110 MixCom4_000099 COc1cc2CCN(Cc2cc1OC)S(=O)(=O)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E16 compound treatment 1338750.0 -292000.0 -1.43 1523200.0 -73900.0 -0.33 1261850.0 -276683.01886792 -1.44215997676603 1485120.0 -40818.2692307699 -0.196809796399369 -1.6986 -0.8218 2079903 MixCom4_000100 CN1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E17 compound treatment 1689090.0 58000.0 0.28 1600560.0 3490.0 0.02 1484600.0 -53933.0188679199 -0.281116063991666 1448890.0 -77048.2692307699 -0.371496745599411 -0.1767 -0.3239 2075111 MixCom4_000101 ClC1=C(CN2CCSCC2)CSc3ccc(Cl)cc13 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E18 compound treatment 1560240.0 -70900.0 -0.35 1680350.0 83300.0 0.37 1185530.0 -353003.01886792 -1.83996411334489 1636960.0 111021.73076923 0.535303545210743 -0.6411 -0.3234 2079904 MixCom4_000102 CN(Cc1ccccc1)c2cc(nc(n2)c3cccnc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E19 compound treatment 1750950.0 120000.0 0.59 1794120.0 197000.0 0.87 1594890.0 56356.9811320801 0.293750526984249 1659320.0 133381.73076923 0.643114756475246 1.1985 0.9454 2075112 MixCom4_000103 CN1CCN(CC1)c2ccccc2/C=C\3/C(=O)Nc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E20 compound treatment 1455750.0 -175000.0 -0.86 1295710.0 -301000.0 -1.34 1315490.0 -223043.01886792 -1.16257122039693 1182470.0 -343468.26923077 -1.65607022078228 -2.5066 -0.9745 2079905 MixCom4_000104 Fc1ccccc1c2cc(NCc3ccncc3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E21 compound treatment 1648370.0 17200.0 0.08 1485090.0 -112000.0 -0.5 1588640.0 50106.9811320801 0.261173537287998 1406340.0 -119598.26923077 -0.576656273296397 -0.3639 -0.4498 2075113 MixCom4_000105 CN(C)/C=C/C(=O)c1nn(ccc1=O)c2ccc(cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E22 compound treatment 1222470.0 -409000.0 -2.0 1014080.0 -583000.0 -2.59 992900.0 -545633.01886792 -2.84401299737508 1145500.0 -380438.26923077 -1.83432516176835 -4.6317 -0.9844 2079906 MixCom4_000106 Fc1ccccc1c2cc(NCc3ccco3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E23 mock treatment 1704350.0 73200.0 0.36 1502290.0 -94800.0 -0.42 1708170.0 169636.98113208 0.884201949830849 1496680.0 -29258.2692307699 -0.141071978768884 0.3406 0.3237 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 E24 mock treatment 1754080.0 123000.0 0.6 1624160.0 27100.0 0.12 1522620.0 -15913.0188679199 -0.0829437202714347 1535010.0 9071.73076923005 0.0437403525266616 0.3413 0.5499 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F01 compound treatment 1617960.0 -13200.0 -0.06 1536700.0 -60400.0 -0.27 1296760.0 -241773.01886792 -1.26019794311866 1449820.0 -76118.2692307699 -0.36701264781426 -0.9797 -0.7305 2079907 MixCom4_000107 Cc1nc(cc(n1)c2cccc(c2)C(F)(F)F)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F02 compound treatment 1621480.0 -9650.0 -0.05 1574430.0 -22600.0 -0.1 1512840.0 -25693.0188679199 -0.133920193748127 1563950.0 38011.7307692301 0.183277761023742 -0.0491 -0.1944 2075088 MixCom4_000108 Fc1ccc(cc1Cl)S(=O)(=O)NN2C3CSC2CS3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F03 compound treatment 1373290.0 -258000.0 -1.26 1379010.0 -218000.0 -0.97 967790.0 -570743.01886792 -2.97489431117874 1261190.0 -264748.26923077 -1.27651304051655 -3.2401 -0.8984 2079909 MixCom4_000109 Cc1nc(NCc2ccc(Cl)cc2)cc(n1)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F04 compound treatment 1606610.0 -24500.0 -0.12 1354290.0 -243000.0 -1.08 1221570.0 -316963.01886792 -1.65211215996043 1564060.0 38121.7307692301 0.183808138181125 -1.3325 -0.6716 1214022 MixCom4_000110 Cc1ccc(cc1)C(=O)N2CCN(Cc3ccc4OCOc4c3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F05 compound treatment 1529390.0 -102000.0 -0.5 1519040.0 -78000.0 -0.35 1316010.0 -222523.01886792 -1.1598608148542 1280290.0 -245648.26923077 -1.18442027955268 -1.5941 -0.9031 2079911 MixCom4_000111 Fc1ccc(cc1)c2cnc(nc2)N3CCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F06 mock treatment 1736210.0 105000.0 0.51 1755790.0 159000.0 0.7 1480740.0 -57793.0188679199 -0.30123561282807 1691870.0 165931.73076923 0.800058178955549 0.8585 0.7031 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F07 compound treatment 1682080.0 51000.0 0.25 1778530.0 181000.0 0.8 1656850.0 118316.98113208 0.616705772036998 1615640.0 89701.7307692301 0.432506808888775 1.0516 0.9306 2079912 MixCom4_000112 CC(C)N(C(C)C)c1ccc(cc1F)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F08 mock treatment 1489760.0 -141000.0 -0.69 1498740.0 -98300.0 -0.44 1417960.0 -120573.01886792 -0.628464958928967 1656160.0 130221.73076923 0.627878467226774 -0.5642 -0.4673 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F09 compound treatment 1678110.0 47000.0 0.23 1347430.0 -250000.0 -1.11 1674170.0 135636.98113208 0.706983125883247 1450830.0 -75108.2692307699 -0.362142821187375 -0.2662 -0.1926 2079913 MixCom4_000113 CS(=O)(=O)c1ccc(N2CCc3ccccc3C2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F10 mock treatment 1712690.0 81600.0 0.4 1543720.0 -53300.0 -0.24 1429560.0 -108973.01886792 -0.568002066052726 1555940.0 30001.7307692301 0.144656660745179 -0.1304 -0.1744 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F11 compound treatment 1728740.0 97600.0 0.48 1650790.0 53700.0 0.24 1302810.0 -235723.01886792 -1.22866341709269 1425190.0 -100748.26923077 -0.48576891496295 -0.4993 -0.3504 2079914 MixCom4_000114 CS(=O)(=O)c1ccc(cc1)N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F12 compound treatment 1696320.0 65200.0 0.32 1509380.0 -87700.0 -0.39 1460070.0 -78463.0188679199 -0.408974233151509 1467200.0 -58738.2692307699 -0.283213056947665 -0.381 -0.5386 2079948 MixCom4_000115 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F13 compound treatment 1645970.0 14800.0 0.07 1399000.0 -198000.0 -0.88 1702330.0 163796.98113208 0.853762010658673 1662610.0 136671.73076923 0.658977855091535 0.3535 0.2538 2079916 MixCom4_000116 CC(Nc1ccc(cc1)S(=O)(=O)C)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F14 compound treatment 1683710.0 52600.0 0.26 1784720.0 188000.0 0.83 1549800.0 11266.9811320801 0.0587270925196194 1555250.0 29311.7307692301 0.141329749485228 0.6448 0.7291 2079950 MixCom4_000117 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)c4ccc(Cl)cc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F15 compound treatment 1665090.0 34000.0 0.17 1628960.0 31900.0 0.14 1401780.0 -136753.01886792 -0.71280026985462 1289650.0 -236288.26923077 -1.13929000506987 -0.7722 -0.5672 2079918 MixCom4_000118 CS(=O)(=O)c1ccc(N2CCN(CC2)C(=O)c3c(F)cccc3F)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F16 compound treatment 1701960.0 70800.0 0.35 1596480.0 -589.0 0.0 1574020.0 35486.9811320801 0.184969442990529 1345450.0 -180488.26923077 -0.870244137960779 -0.1706 -0.1787 2079952 MixCom4_000119 Fc1c(F)c(F)c2c(CC(=O)NCCN3CCOCC3)c[nH]c2c1F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F17 compound treatment 1583620.0 -47500.0 -0.23 1690080.0 93000.0 0.41 1385470.0 -153063.01886792 -0.797813182165955 1415700.0 -110238.26923077 -0.531525998813582 -0.5747 -0.5375 2079920 MixCom4_000120 CS(=O)(=O)c1ccc(cc1)N2CCCC(O)C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F18 compound treatment 1270000.0 -361000.0 -1.77 1682370.0 85300.0 0.38 1543730.0 5196.98113208008 0.0270883201266209 1385250.0 -140688.26923077 -0.678344039198381 -1.0201 -0.5284 2079726 MixCom4_000121 OC(=O)C1CCN(Cc2ccccn2)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F19 compound treatment 1826150.0 195000.0 0.95 1759490.0 162000.0 0.72 1555880.0 17346.9811320801 0.0904179880961319 1293440.0 -232498.26923077 -1.12101610119275 0.322 0.1962 2079922 MixCom4_000122 CC(C)CC(=O)N1CCc2nc3ccccn3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F20 compound treatment 1628160.0 -2970.0 -0.01 1436920.0 -160000.0 -0.71 1493160.0 -45373.0188679199 -0.236498618903681 1290530.0 -235408.26923077 -1.1350469878108 -1.0481 -0.7708 2079966 MixCom4_000123 Clc1ccc(cc1)c2csc(c2)C(=O)NCCN3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F21 compound treatment 1642910.0 11800.0 0.06 1507650.0 -89400.0 -0.4 1465980.0 -72553.0188679199 -0.378169431694735 1220540.0 -305398.26923077 -1.47251150822236 -1.0948 -0.6963 2079924 MixCom4_000124 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F22 compound treatment 1739740.0 109000.0 0.53 1685440.0 88400.0 0.39 1667440.0 128906.98113208 0.671904223378324 1520170.0 -5768.26923076995 -0.0278123476148958 0.7837 0.8316 2079734 MixCom4_000125 OC(=O)C1CCN(Cc2ccncc2)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F23 mock treatment 1612520.0 -18600.0 -0.09 1688710.0 91600.0 0.41 1619930.0 81396.9811320801 0.424266978503307 1376890.0 -149048.26923077 -0.718652703159528 0.0105 0.0112 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 F24 mock treatment 1654880.0 23800.0 0.12 1509050.0 -88000.0 -0.39 1582240.0 43706.9811320801 0.227814699839038 1325120.0 -200818.26923077 -0.968267479866295 -0.5073 -0.472 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G01 compound treatment 1247520.0 -384000.0 -1.88 1311540.0 -286000.0 -1.27 1337920.0 -200613.01886792 -1.04565891977503 1367110.0 -158828.26923077 -0.765808054061444 -2.4774 -0.9496 2075114 MixCom4_000126 COc1ccc(CN2CCCN(Cc3ccc(OC)cc3)C2c4cccnc4)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G02 compound treatment 1228700.0 -402000.0 -1.97 1158360.0 -439000.0 -1.95 1404930.0 -133603.01886792 -0.69638146704771 1149120.0 -376818.26923077 -1.81687093167991 -3.214 -0.9499 2079926 MixCom4_000127 Fc1ccc(cc1)c2cc(nc(n2)c3ccccc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G03 compound treatment 1305840.0 -325000.0 -1.59 1635090.0 38000.0 0.17 1327550.0 -210983.01886792 -1.09971066107905 1567380.0 41441.7307692301 0.199815885113064 -1.1615 -0.595 2075115 MixCom4_000128 CN1CCN(CC1)c2ccc(CNC(=O)c3ccco3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G04 compound treatment 1135640.0 -495000.0 -2.42 1188870.0 -408000.0 -1.81 1001440.0 -537093.01886792 -2.79949979865413 1268980.0 -256958.26923077 -1.23895269455275 -4.1367 -0.961 2079927 MixCom4_000129 Fc1ccc(cc1)c2cc(nc(n2)c3cccnc3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G05 compound treatment 1538740.0 -92400.0 -0.45 1512320.0 -84700.0 -0.38 1219680.0 -318853.01886792 -1.66196344164457 1584680.0 58741.7307692301 0.283229747137925 -1.1033 -0.6179 2075116 MixCom4_000130 OC(CN1CCCc2cc(ccc12)C(=O)O)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G06 compound treatment 1523110.0 -108000.0 -0.53 1485970.0 -111000.0 -0.49 1433610.0 -104923.01886792 -0.546892176729555 1540870.0 14931.7307692301 0.0719949901836377 -0.7481 -0.8229 2079928 MixCom4_000131 Fc1ccc(cc1)c2cc(NC3CC3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G07 compound treatment 1678110.0 47000.0 0.23 1570560.0 -26500.0 -0.12 1436490.0 -102043.01886792 -0.531880699877523 1521360.0 -4578.26923076995 -0.0220746310941105 -0.2208 -0.3732 2075117 MixCom4_000132 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3ccc(F)cc3Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G08 compound treatment 1299140.0 -332000.0 -1.62 1323040.0 -274000.0 -1.22 1356410.0 -182123.01886792 -0.949283153457641 1307380.0 -218558.26923077 -1.05380285052069 -2.4214 -0.9782 2079929 MixCom4_000133 Fc1ccc(cc1)c2cc(NCc3ccco3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G09 compound treatment 1661920.0 30800.0 0.15 1321950.0 -275000.0 -1.22 1526560.0 -11973.0188679199 -0.0624071859669184 1514980.0 -10958.2692307699 -0.0528365062223542 -0.5923 -0.4808 2075118 MixCom4_000134 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3cc(C)sc3C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G10 compound treatment 1625600.0 -5530.0 -0.03 1436520.0 -161000.0 -0.71 1344550.0 -193983.01886792 -1.01110124910525 1594810.0 68871.7307692301 0.332072661722425 -0.709 -0.5536 2079930 MixCom4_000135 CCN(CC)c1cc(nc(C)n1)c2ccccc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G11 compound treatment 1624800.0 -6330.0 -0.03 1565920.0 -31100.0 -0.14 1384160.0 -154373.01886792 -0.804641319206289 1603960.0 78021.7307692301 0.37619039799569 -0.2988 -0.3322 2075119 MixCom4_000136 OC(CN1CCN(Cc2c(F)cccc2Cl)CC1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G12 compound treatment 1716560.0 85400.0 0.42 1719290.0 122000.0 0.54 1440680.0 -97853.0188679199 -0.510041085985157 1572960.0 47021.7307692301 0.226720471823973 0.3384 0.3831 2079931 MixCom4_000137 Cc1nc(cc(n1)c2ccccc2F)N3CCC(O)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G13 compound treatment 1486080.0 -145000.0 -0.71 1557120.0 -39900.0 -0.18 1603110.0 64576.9811320801 0.336595783832757 1508560.0 -17378.2692307699 -0.0837912457714646 -0.3171 -0.3916 2075120 MixCom4_000138 O=C(N1CCSCC1)c2nc3ccccc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G14 compound treatment 1454560.0 -177000.0 -0.86 1510970.0 -86100.0 -0.38 1347790.0 -190743.01886792 -0.99421333764671 1526750.0 811.730769230053 0.00391384961768151 -1.1181 -0.8153 2079932 MixCom4_000139 Cc1nc(NC2CC2)cc(n1)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G15 compound treatment 1659700.0 28600.0 0.14 1676770.0 79700.0 0.35 1493510.0 -45023.0188679199 -0.234674307480691 1489770.0 -36168.2692307699 -0.174389307473612 0.0421 0.0878 1461440 MixCom4_000140 COc1cc2CCN(Cc2cc1OC)S(=O)(=O)c3ccc(F)c(F)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G16 compound treatment 1157780.0 -473000.0 -2.32 1086270.0 -511000.0 -2.27 1247200.0 -291333.01886792 -1.51852044061404 1428560.0 -97378.2692307699 -0.469520087504927 -3.2848 -0.9102 2079933 MixCom4_000141 OC1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G17 compound treatment 1137170.0 -494000.0 -2.42 1252570.0 -344000.0 -1.53 1324370.0 -214163.01886792 -1.1162858334365 799520.0 -726418.26923077 -3.50250597005515 -4.2818 -0.9194 2075121 MixCom4_000142 ClC1=C(CN2CCCCC2)CSc3ccc(Cl)cc13 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G18 compound treatment 1217280.0 -414000.0 -2.03 1343770.0 -253000.0 -1.12 1281130.0 -257403.01886792 -1.34166647895104 1255440.0 -270498.26923077 -1.30423730101614 -2.8972 -0.9731 2079934 MixCom4_000143 Fc1ccccc1c2cc(NCC=C)nc(n2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G19 compound treatment 1621250.0 -9880.0 -0.05 1470780.0 -126000.0 -0.56 1496480.0 -42053.0188679199 -0.219193721977033 1293600.0 -232338.26923077 -1.12024464350928 -0.9739 -0.7654 2075122 MixCom4_000144 CN1CCN(CC1)c2ccccc2/C=N/c3cc(Cl)cc(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G20 compound treatment 891610.0 -740000.0 -3.62 1033780.0 -563000.0 -2.5 1155440.0 -383093.01886792 -1.99680277253851 1210530.0 -315408.26923077 -1.52077582954426 -4.8172 -0.9514 2079935 MixCom4_000145 Fc1ccccc1c2cc(nc(n2)c3ccncc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G21 compound treatment 1696000.0 64900.0 0.32 1281770.0 -315000.0 -1.4 1522820.0 -15713.0188679199 -0.0819012566011546 1330610.0 -195328.26923077 -0.941796838102336 -1.0523 -0.6127 2075123 MixCom4_000146 COCc1cc(nc(n1)c2csc(C)n2)N(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G22 compound treatment 1011720.0 -619000.0 -3.03 1392820.0 -204000.0 -0.91 1392640.0 -145893.01886792 -0.760440859586417 1365640.0 -160298.26923077 -0.772895821528296 -2.7351 -0.8179 2079936 MixCom4_000147 CC(Nc1cc(nc(n1)c2ccncc2)c3ccccc3F)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G23 mock treatment 1674490.0 43400.0 0.21 1544370.0 -52700.0 -0.23 1572770.0 34236.9811320801 0.178454045051279 1366720.0 -159218.26923077 -0.767688482164894 -0.3054 -0.3597 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 G24 mock treatment 1595970.0 -35200.0 -0.17 1606690.0 9620.0 0.04 1587160.0 48626.9811320801 0.253459306127926 1396100.0 -129838.26923077 -0.62602956503828 -0.251 -0.3594 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H01 compound treatment 1503620.0 -128000.0 -0.62 1579360.0 -17700.0 -0.08 1515110.0 -23423.0188679199 -0.122088231090449 1519240.0 -6698.26923076995 -0.0322964454000473 -0.4284 -0.6679 2079937 MixCom4_000148 CN(Cc1ccccc1)c2cc(nc(C)n2)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H02 compound treatment 1554240.0 -76900.0 -0.38 1530440.0 -66600.0 -0.3 1673980.0 135446.98113208 0.705992785396481 1427420.0 -98518.2692307699 -0.475016723499629 -0.2204 -0.2258 2075089 MixCom4_000149 FC(F)(F)C1CCN(CC1)c2ccc(cc2NC(=O)c3cccs3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H03 compound treatment 1416130.0 -215000.0 -1.05 1266120.0 -331000.0 -1.47 1076750.0 -461783.01886792 -2.40696010361019 1259010.0 -266928.26923077 -1.28702415145379 -3.1069 -0.9493 2079939 MixCom4_000150 Cc1nc(NC2CC2)cc(n1)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H04 compound treatment 1489340.0 -142000.0 -0.69 1537650.0 -59400.0 -0.26 1264160.0 -274373.01886792 -1.4301195213743 1488700.0 -37238.2692307699 -0.179548430731797 -1.2835 -0.7917 1510899 MixCom4_000151 O=C(N1CCN(Cc2ccc3OCOc3c2)CC1)c4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H05 compound treatment 1508480.0 -123000.0 -0.6 1567650.0 -29400.0 -0.13 1279470.0 -259063.01886792 -1.35031892741436 1645230.0 119291.73076923 0.57517826422494 -0.7529 -0.4732 1653366 MixCom4_000152 OC(=O)CC1(CC(=O)NC2CC2)CCCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H06 mock treatment 1492430.0 -139000.0 -0.68 1706990.0 110000.0 0.49 1655230.0 116696.98113208 0.608261816307729 1556500.0 30561.7307692301 0.147356762637313 0.2822 0.2703 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H07 compound treatment 1544190.0 -86900.0 -0.43 1556440.0 -40600.0 -0.18 967200.0 -571333.01886792 -2.97796957900607 1375580.0 -150358.26923077 -0.724969012942913 -2.1543 -0.695 2079941 MixCom4_000153 CS(=O)(=O)c1ccc(N2CCC3(CC2)OCCO3)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H08 mock treatment 1551150.0 -80000.0 -0.39 1438560.0 -159000.0 -0.7 1503440.0 -35093.0188679199 -0.182915986251288 1630560.0 104621.73076923 0.504445237872066 -0.3864 -0.3995 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H09 compound treatment 1605350.0 -25800.0 -0.13 1722880.0 126000.0 0.56 1414270.0 -124263.01886792 -0.647698413645633 1681090.0 155151.73076923 0.748081217531965 0.2661 0.2328 2079942 MixCom4_000154 CS(=O)(=O)c1ccc(NCCc2ccccc2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H10 mock treatment 1655650.0 24500.0 0.12 1715790.0 119000.0 0.53 1466290.0 -72243.0188679199 -0.376553613005801 1649440.0 123501.73076923 0.595477244521164 0.4327 0.4875 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H11 compound treatment 1605810.0 -25300.0 -0.12 1339880.0 -257000.0 -1.14 1397120.0 -141413.01886792 -0.737089673372144 1485190.0 -40748.2692307699 -0.196472283662852 -1.099 -0.7977 2079943 MixCom4_000155 CS(=O)(=O)c1ccc(cc1)N2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H12 compound treatment 1642570.0 11400.0 0.06 1593960.0 -3110.0 -0.01 1432930.0 -105603.01886792 -0.550436553208507 1641060.0 115121.73076923 0.555072148349583 0.0234 0.0299 2079972 MixCom4_000156 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)c4c(F)cccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H13 compound treatment 1705350.0 74200.0 0.36 1719330.0 122000.0 0.54 1673760.0 135226.98113208 0.704846075359173 1556800.0 30861.7307692301 0.148803245793814 0.8795 0.9048 2079945 MixCom4_000157 CC1CN(CC(C)O1)c2ccc(cc2)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H14 compound treatment 1635530.0 4400.0 0.02 1691680.0 94600.0 0.42 1358520.0 -180013.01886792 -0.938285161736187 1674640.0 148701.73076923 0.716981829667204 0.1099 0.0877 2079974 MixCom4_000158 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)Cc4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H15 compound treatment 1707890.0 76800.0 0.38 1714900.0 118000.0 0.52 1512960.0 -25573.0188679199 -0.133294715545959 1499280.0 -26658.2692307699 -0.128535791412546 0.3182 0.4751 2079947 MixCom4_000159 CS(=O)(=O)c1ccc(cc1)N2CCC(O)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H16 compound treatment 1664450.0 33300.0 0.16 1662300.0 65200.0 0.29 1676160.0 137626.98113208 0.717355639402533 1687200.0 161261.73076923 0.777541257819358 0.9736 0.8781 2079653 MixCom4_000160 O=C1Cc2ccccc2N1C3CCN(CCC#N)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H17 compound treatment 1653650.0 22500.0 0.11 1660060.0 63000.0 0.28 1540080.0 1546.98113208008 0.00806335814401067 1255860.0 -270078.26923077 -1.30221222459704 -0.4523 -0.3384 2079949 MixCom4_000161 CS(=O)(=O)c1ccc(N2CCCC(O)C2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H18 compound treatment 1709600.0 78500.0 0.38 1642680.0 45600.0 0.2 1427360.0 -111173.01886792 -0.579469166425806 1334930.0 -191008.26923077 -0.920967480648729 -0.4571 -0.3902 2079977 MixCom4_000162 C1CN(CCO1)C2c3cccn3-c4ccccc24 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H19 compound treatment 1155880.0 -475000.0 -2.33 1131160.0 -466000.0 -2.07 1154370.0 -384163.01886792 -2.00237995317451 1006030.0 -519908.26923077 -2.50679518122543 -4.4505 -0.9959 2079951 MixCom4_000163 CC(C)(C)c1ccc(cc1)C(=O)N2CCc3nc4ccccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H20 compound treatment 1617500.0 -13600.0 -0.07 1686490.0 89400.0 0.4 1616800.0 78266.9811320801 0.407952422063425 1579480.0 53541.7307692301 0.25815737242525 0.498 0.7926 2079979 MixCom4_000164 CN1CCN(CC1)C(=O)c2cc(cs2)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H21 compound treatment 1590920.0 -40200.0 -0.2 1728570.0 132000.0 0.58 1698410.0 159876.98113208 0.833329722721185 1300060.0 -225878.26923077 -1.0890970395393 0.0653 0.0435 2079953 MixCom4_000165 CC(=O)N1CCc2nc3c(C)cccn3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H22 compound treatment 1522530.0 -109000.0 -0.53 1546260.0 -50800.0 -0.23 1577690.0 39156.9811320801 0.204098651340168 1407710.0 -118228.26923077 -0.570050666881711 -0.5613 -0.671 2079981 MixCom4_000166 CN1CCC(CC1)N(C(=O)c2ccc(cc2)C(F)(F)F)c3ccc4CCN(C(=O)C)c4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H23 mock treatment 1562720.0 -68400.0 -0.33 1494610.0 -102000.0 -0.45 1704860.0 166326.98113208 0.866949176087715 1289240.0 -236698.26923077 -1.14126686538375 -0.5317 -0.3452 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 H24 mock treatment 1148800.0 -482000.0 -2.36 1721920.0 125000.0 0.55 1552840.0 14306.9811320801 0.0745725403078756 1505440.0 -20498.2692307699 -0.0988346705990697 -0.9154 -0.3771 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I01 compound treatment 1478010.0 -153000.0 -0.75 1574150.0 -22900.0 -0.1 1264210.0 -274323.01886792 -1.42985890545673 1550580.0 24641.7307692301 0.118812828349037 -1.081 -0.6665 2075124 MixCom4_000167 COc1ccc(CC(=O)Nc2ccccc2N3CCCCC3)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I02 compound treatment 1488880.0 -142000.0 -0.7 1566630.0 -30400.0 -0.13 1270000.0 -268533.01886792 -1.39967958220212 1540250.0 14311.7307692301 0.0690055916602034 -1.0809 -0.6882 2079954 MixCom4_000168 Fc1ccc(cc1)c2cc(nc(n2)c3ccccc3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I03 compound treatment 1499310.0 -132000.0 -0.65 1374900.0 -222000.0 -0.99 1142980.0 -395553.01886792 -2.06174825919696 1551410.0 25471.7307692301 0.122814765082021 -1.7846 -0.7506 2075125 MixCom4_000169 CN1CCN(CC1)c2ccc(CNC(=O)c3cc4ccccc4o3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I04 compound treatment 1430420.0 -201000.0 -0.98 1478010.0 -119000.0 -0.53 1295800.0 -242733.01886792 -1.265201768736 1373940.0 -151998.26923077 -0.732876454198449 -1.7541 -0.9539 2079955 MixCom4_000170 CN(Cc1ccccc1)c2cc(nc(n2)c3cccnc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I05 compound treatment 1740930.0 110000.0 0.54 1649980.0 52900.0 0.23 1499710.0 -38823.0188679199 -0.20235793370201 1612640.0 86701.7307692301 0.418041977323771 0.4938 0.6602 2075126 MixCom4_000171 OC(CN1CCN(Cc2ccc3OCOc3c2)CC1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I06 compound treatment 1393760.0 -237000.0 -1.16 1248220.0 -349000.0 -1.55 1346910.0 -191623.01886792 -0.998800177795942 1266130.0 -259808.26923077 -1.25269428453951 -2.48 -0.9873 2079956 MixCom4_000172 CCN(CC)c1cc(nc(n1)c2ccncc2)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I07 compound treatment 1631680.0 553.0 0.0 1684640.0 87600.0 0.39 1447070.0 -91463.0188679199 -0.47673437171971 1523050.0 -2888.26923076995 -0.0139261093124911 -0.0498 -0.081 2075127 MixCom4_000173 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3cccc(F)c3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I08 compound treatment 962500.0 -669000.0 -3.27 955270.0 -642000.0 -2.85 1051850.0 -486683.01886792 -2.53674683056005 1224280.0 -301658.26923077 -1.45447868487132 -5.0547 -0.9664 2079957 MixCom4_000174 Fc1ccc(cc1)c2cc(NCc3ccc(Cl)cc3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I09 compound treatment 1659680.0 28600.0 0.14 1683890.0 86800.0 0.39 1589970.0 51436.9811320801 0.26810592069536 1600570.0 74631.7307692301 0.359845138327234 0.5764 0.9486 2075128 MixCom4_000175 OC(CNC1CCN(Cc2ccccc2)CC1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I10 compound treatment 1589150.0 -42000.0 -0.21 1658890.0 61800.0 0.27 1526880.0 -11653.0188679199 -0.0607392440944703 1471740.0 -54198.2692307699 -0.261322945179291 -0.1267 -0.2911 2079958 MixCom4_000176 CCC(=O)N(C1CCN(CCc2ccccc2)CC1)c3ccc4[nH]c(C)cc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I11 compound treatment 1715800.0 84700.0 0.41 1624730.0 27700.0 0.12 1489310.0 -49223.0188679199 -0.256566044556571 1560990.0 35051.7307692301 0.169005793879604 0.2247 0.4238 2075129 MixCom4_000177 OC(CN1CCN(CC1)c2ccc(F)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I12 compound treatment 1533920.0 -97200.0 -0.48 1643600.0 46500.0 0.21 1464060.0 -74473.0188679199 -0.388177082929423 1500800.0 -25138.2692307699 -0.121206943419611 -0.3894 -0.5909 2079959 MixCom4_000178 Cc1nc(NCc2ccccc2)cc(n1)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I13 compound treatment 1598680.0 -32400.0 -0.16 1458330.0 -139000.0 -0.62 1320980.0 -217553.01886792 -1.13395559264775 1261640.0 -264298.26923077 -1.2743433157818 -1.5912 -0.8741 2075130 MixCom4_000179 O=C(Nc1ccccc1N2CCOCC2)c3nc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I14 compound treatment 1234400.0 -397000.0 -1.94 1246350.0 -351000.0 -1.56 1285520.0 -253013.01886792 -1.31878440138839 1226240.0 -299698.26923077 -1.44502832824886 -3.1303 -0.9891 2079960 MixCom4_000180 Cc1nc(NCCc2c[nH]c3ccccc23)cc(n1)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I15 compound treatment 1679290.0 48200.0 0.24 1766040.0 169000.0 0.75 1285480.0 -253053.01886792 -1.31899289412245 1336640.0 -189298.26923077 -0.912722526656676 -0.6233 -0.349 2075131 MixCom4_000181 O=C1C2CCN(CC2)C31CC3c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I16 compound treatment 808600.0 -823000.0 -4.02 895330.0 -702000.0 -3.11 640990.0 -897543.01886792 -4.67827994841628 810890.0 -715048.26923077 -3.44768425842378 -7.6315 -0.988 2079961 MixCom4_000182 CCCN1CCC(CC1)N(C2CC2)C(=O)c3cccc(NC(=O)c4ccc(cc4)C(C)(C)C)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I17 compound treatment 1684980.0 53900.0 0.26 1661520.0 64500.0 0.29 1571470.0 32936.9811320801 0.171678031194459 1278260.0 -247678.26923077 -1.19420814891167 -0.2366 -0.1866 2075132 MixCom4_000183 CCN(CC)C(=O)c1cc2sccc2s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I18 compound treatment 1272560.0 -359000.0 -1.75 1363330.0 -234000.0 -1.04 1410520.0 -128013.01886792 -0.667244607463383 1393700.0 -132238.26923077 -0.637601430290284 -2.048 -0.9155 2079962 MixCom4_000184 CN1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I19 compound treatment 1672280.0 41200.0 0.2 1643650.0 46600.0 0.21 1702950.0 164416.98113208 0.856993648036541 1613160.0 87221.7307692301 0.420549214795038 0.8427 0.8451 2075133 MixCom4_000185 Cc1c(C)c(C)c(CS/C(=N/c2cc(Cl)ccc2Cl)/N3CCOCC3)c(C)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I20 compound treatment 842300.0 -789000.0 -3.86 1083970.0 -513000.0 -2.28 1321760.0 -216773.01886792 -1.12988998433365 1222970.0 -302968.26923077 -1.46079499465471 -4.3631 -0.9003 2079963 MixCom4_000186 Fc1ccccc1c2cc(nc(n2)c3ccncc3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I21 compound treatment 1481360.0 -150000.0 -0.73 1331380.0 -266000.0 -1.18 1369920.0 -168613.01886792 -0.878864732530226 1108130.0 -417808.26923077 -2.0145087469631 -2.4023 -0.9242 2075134 MixCom4_000187 COC(=O)c1c(/C=C/N(C)C)onc1c2c(Cl)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I22 compound treatment 1324070.0 -307000.0 -1.5 1385920.0 -211000.0 -0.94 1286590.0 -251943.01886792 -1.31320722075239 1178240.0 -347698.26923077 -1.67646563328893 -2.7143 -0.9801 2079964 MixCom4_000188 Fc1ccccc1c2cc(NC3CC3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I23 mock treatment 1696520.0 65400.0 0.32 1552800.0 -44300.0 -0.2 1618720.0 80186.9811320801 0.417960073298113 1385930.0 -140008.26923077 -0.675065344043646 -0.0667 -0.076 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 I24 mock treatment 1604720.0 -26400.0 -0.13 1674110.0 77000.0 0.34 1631920.0 93386.9811320801 0.486762675536594 1481520.0 -44418.2692307699 -0.214167594277375 0.2425 0.3759 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J01 compound treatment 1280820.0 -350000.0 -1.71 1441530.0 -156000.0 -0.69 1463150.0 -75383.0188679199 -0.392920292629197 1353060.0 -172878.26923077 -0.833551681890883 -1.8152 -0.8791 2079965 MixCom4_000189 Cc1nc(NCC=C)cc(n1)c2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J02 compound treatment 862250.0 -769000.0 -3.76 1001620.0 -595000.0 -2.64 957280.0 -581253.01886792 -3.02967577705195 887360.0 -638578.26923077 -3.0789757018318 -6.2559 -0.9918 2075100 MixCom4_000190 COc1ccc(NC(=O)Nc2cc(ccc2N3CCC(CC3)C(F)(F)F)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J03 compound treatment 1424370.0 -207000.0 -1.01 1621850.0 24800.0 0.11 1679580.0 141046.98113208 0.735181768164321 1579910.0 53971.7307692301 0.260230664949568 0.0468 0.0365 2079967 MixCom4_000191 FC(F)(F)c1cccc(c1)c2cc(NC3CC3)nc(n2)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J04 compound treatment 1391610.0 -240000.0 -1.17 1609090.0 12000.0 0.05 1542140.0 3606.98113208008 0.0188007339478948 1537470.0 11531.7307692301 0.0556015144099655 -0.5222 -0.4445 1151412 MixCom4_000192 CC(C)(C)C(=O)N1CCN(Cc2ccc3OCOc3c2)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J05 compound treatment 1514560.0 -117000.0 -0.57 1651240.0 54200.0 0.24 1290330.0 -248203.01886792 -1.29371315011816 1540640.0 14701.7307692301 0.070886019763654 -0.7765 -0.5408 2079968 MixCom4_000193 CNC(=O)CC1(CC(=O)O)CCCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J06 mock treatment 1579060.0 -52100.0 -0.25 1675360.0 78300.0 0.35 1633640.0 95106.9811320801 0.495727863101002 1696340.0 170401.73076923 0.821610777987406 0.7049 0.6702 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J07 compound treatment 1558400.0 -72700.0 -0.36 1581760.0 -15300.0 -0.07 1267080.0 -271453.01886792 -1.41489955178821 1537540.0 11601.7307692301 0.0559390271464823 -0.8914 -0.6098 2079969 MixCom4_000194 CS(=O)(=O)c1ccc(NCc2cccnc2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J08 mock treatment 1655150.0 24000.0 0.12 1589760.0 -7310.0 -0.03 1353300.0 -185233.01886792 -0.965493463530496 1609140.0 83201.7307692301 0.401166340497932 -0.2396 -0.2276 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J09 compound treatment 1635840.0 4710.0 0.02 1646410.0 49300.0 0.22 1387530.0 -151003.01886792 -0.787075806362071 1641440.0 115501.73076923 0.556904360347817 0.0059 0.0059 2079970 MixCom4_000195 CS(=O)(=O)c1ccc(N2CCN(CC2)c3ccccn3)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J10 mock treatment 1612800.0 -18300.0 -0.09 1681860.0 84800.0 0.38 1422330.0 -116203.01886792 -0.605687127733348 1550350.0 24411.7307692301 0.117703857929053 -0.1008 -0.1385 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J11 compound treatment 1715010.0 83900.0 0.41 1673960.0 76900.0 0.34 1534370.0 -4163.01886791992 -0.0216989796424838 1575950.0 50011.7307692301 0.241137087283761 0.4855 0.8284 2079971 MixCom4_000196 CN1CCN(CC1)c2ccc(cc2)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J12 compound treatment 1602250.0 -28900.0 -0.14 1678720.0 81700.0 0.36 1444930.0 -93603.0188679199 -0.487888732991707 1580690.0 54751.7307692301 0.263991521156469 -0.0016 -0.0023 2079994 MixCom4_000197 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J13 compound treatment 1650610.0 19500.0 0.1 1637620.0 40600.0 0.18 1273090.0 -265443.01886792 -1.3835735184963 1497980.0 -27958.2692307699 -0.134803885090715 -0.6216 -0.4424 2079973 MixCom4_000198 CS(=O)(=O)c1ccc(cc1)N2CCN(CC2)C(=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J14 compound treatment 1730640.0 99500.0 0.49 1733310.0 136000.0 0.6 1674980.0 136446.98113208 0.711205103747881 1724160.0 198221.73076923 0.955747982700218 1.3791 0.97 2079996 MixCom4_000199 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)C4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J15 compound treatment 1725060.0 93900.0 0.46 1725170.0 128000.0 0.57 1645440.0 106906.98113208 0.557233219647523 1629800.0 103861.73076923 0.500780813875598 1.0429 0.9965 2079975 MixCom4_000200 CS(=O)(=O)c1ccc(N2CCC(O)CC2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J16 compound treatment 53220.0 -1580000.0 -7.72 82600.0 -1510000.0 -6.72 73040.0 -1465493.01886792 -7.63861615609396 125970.0 -1399968.26923077 -6.75010173692482 -14.4132 -0.9978 2080001 MixCom4_000201 CN(C)CCC(=O)c1ccc(cc1)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J17 compound treatment 1640740.0 9610.0 0.05 1587160.0 -9910.0 -0.04 1604450.0 65916.9811320801 0.343580290423634 1293680.0 -232258.26923077 -1.11985891466755 -0.3866 -0.3295 2079976 MixCom4_000202 FC(F)(F)c1cccc(c1)C(=O)N2CCc3nc4ccccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J18 compound treatment 1602720.0 -28400.0 -0.14 1612760.0 15700.0 0.07 1588910.0 50376.9811320801 0.262580863242876 1303850.0 -222088.26923077 -1.07082313566218 -0.4388 -0.3941 2079730 MixCom4_000203 O=C(C1CCN(Cc2ccccn2)CC1)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J19 compound treatment 1549440.0 -81700.0 -0.4 1683540.0 86500.0 0.38 1505280.0 -33253.0188679199 -0.173325320484712 1245490.0 -280448.26923077 -1.35221232570674 -0.7709 -0.5239 2079978 MixCom4_000204 O=C(N1CCc2nc3ccccn3c(=O)c2C1)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J20 compound treatment 1605230.0 -25900.0 -0.13 1570760.0 -26300.0 -0.12 1592590.0 54056.9811320801 0.281762194776029 1544660.0 18721.7307692301 0.0902688940607605 0.0643 0.1879 2080004 MixCom4_000205 CCCN1CCC(CC1)N(C(=O)C2CC2)c3ccc4[nH]c(cc4c3)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J21 compound treatment 1689770.0 58600.0 0.29 1542620.0 -54400.0 -0.24 1623200.0 84666.9811320801 0.441311259512385 1584110.0 58171.7307692301 0.280481429140574 0.3836 0.5962 2079980 MixCom4_000206 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)c4ccc(Cl)cc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J22 compound treatment 1651220.0 20100.0 0.1 1515060.0 -82000.0 -0.36 1383630.0 -154903.01886792 -0.807403847932531 1334820.0 -191118.26923077 -0.921497857806113 -0.9971 -0.7779 2079773 MixCom4_000207 Cc1ccccc1C(=O)N2CCC(CC2)N3CCN(CC3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J23 mock treatment 1495890.0 -135000.0 -0.66 1524840.0 -72200.0 -0.32 1396610.0 -141923.01886792 -0.739747955731358 1400270.0 -125668.26923077 -0.605923449162923 -1.1639 -0.9649 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 J24 mock treatment 1587360.0 -43800.0 -0.21 1231550.0 -366000.0 -1.62 1581500.0 42966.9811320801 0.223957584259002 1504180.0 -21758.2692307699 -0.104909899856372 -0.8581 -0.5189 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K01 compound treatment 1468960.0 -162000.0 -0.79 1490310.0 -107000.0 -0.47 1391370.0 -147163.01886792 -0.767060503892695 1499750.0 -26188.2692307699 -0.126269634467362 -1.0802 -0.8945 2075135 MixCom4_000208 COc1ccc(CC(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K02 compound treatment 1396000.0 -235000.0 -1.15 1593250.0 -3820.0 -0.02 1612480.0 73946.9811320801 0.385435206785376 1546480.0 20541.7307692301 0.0990442252101968 -0.3415 -0.2805 2079982 MixCom4_000209 CN(Cc1ccccc1)c2cc(nc(n2)c3ccccc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K03 compound treatment 1609130.0 -22000.0 -0.11 1618000.0 20900.0 0.09 1430190.0 -108343.01886792 -0.564718305491344 1285990.0 -239948.26923077 -1.15693709957918 -0.8682 -0.6703 2075136 MixCom4_000210 CN1CCN(CC1)c2ccc(CNC(=O)c3ccsc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K04 compound treatment 1374650.0 -256000.0 -1.26 1508490.0 -88600.0 -0.39 1215560.0 -322973.01886792 -1.68343819325234 1425220.0 -100718.26923077 -0.4856242666473 -1.9085 -0.8712 2079983 MixCom4_000211 Fc1ccc(cc1)c2cc(NCC=C)nc(n2)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K05 compound treatment 1473820.0 -157000.0 -0.77 1599940.0 2870.0 0.01 1497240.0 -41293.0188679199 -0.215232360029969 1576880.0 50941.7307692301 0.245621185068913 -0.3633 -0.4345 2075137 MixCom4_000212 Fc1ccc(cc1)C2CCCN2C(=O)C3CCCCN3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K06 compound treatment 1463380.0 -168000.0 -0.82 1425550.0 -172000.0 -0.76 1028450.0 -510083.01886792 -2.65871507998281 1420750.0 -105188.26923077 -0.507176865679157 -2.3737 -0.8104 2079984 MixCom4_000213 Fc1ccc(cc1)c2cc(nc(n2)c3ccncc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K07 compound treatment 1550570.0 -80600.0 -0.39 1653200.0 56100.0 0.25 1253220.0 -285313.01886792 -1.48714228413862 1593510.0 67571.7307692301 0.325804568044256 -0.6533 -0.4103 2075138 MixCom4_000214 CN1CCN(CC1)c2ccc(CNS(=O)(=O)Cc3ccccc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K08 compound treatment 1022880.0 -608000.0 -2.98 1525240.0 -71800.0 -0.32 1193050.0 -345483.01886792 -1.80076747934236 1484490.0 -41448.2692307699 -0.19984741102802 -2.6478 -0.7567 2079985 MixCom4_000215 Fc1ccc(cc1)c2cc(NC3CC3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K09 compound treatment 1642480.0 11400.0 0.06 1680970.0 83900.0 0.37 1516090.0 -22443.0188679199 -0.116980159106077 1748370.0 222431.73076923 1.07247917342981 0.6916 0.6053 2075139 MixCom4_000216 OC(CNCC1COc2ccccc2O1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K10 compound treatment 1604670.0 -26500.0 -0.13 1638350.0 41300.0 0.18 1330630.0 -207903.01886792 -1.08365672055674 1472800.0 -53138.2692307699 -0.256212038026323 -0.6431 -0.5662 2079986 MixCom4_000217 Cc1nc(cc(n1)c2ccccc2F)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K11 compound treatment 1742910.0 112000.0 0.55 1682590.0 85500.0 0.38 1503260.0 -35273.0188679199 -0.18385420355454 1595150.0 69211.7307692301 0.333712009299792 0.5381 0.7016 2075140 MixCom4_000218 OC(CN1CCN=C(C=C1)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K12 compound treatment 1608000.0 -23100.0 -0.11 1625020.0 28000.0 0.12 1397530.0 -141003.01886792 -0.73495262284807 1286570.0 -239368.26923077 -1.15414056547661 -0.9392 -0.6813 2079987 MixCom4_000219 Cc1nc(NCc2ccco2)cc(n1)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K13 compound treatment 1593950.0 -37200.0 -0.18 1505840.0 -91200.0 -0.4 1576800.0 38266.9811320801 0.199459688007421 1325160.0 -200778.26923077 -0.968074615445428 -0.6776 -0.6254 2075141 MixCom4_000220 COc1cc2CCN(Cc2cc1OC)C(=O)COc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K14 compound treatment 1014130.0 -617000.0 -3.02 1102400.0 -495000.0 -2.19 1032640.0 -505893.01886792 -2.63687546609044 934400.0 -591538.26923077 -2.85216714289253 -5.351 -0.9934 2079988 MixCom4_000221 Cc1cnc(CNc2cc(nc(n2)c3ccccc3)c4ccccc4F)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K15 compound treatment 1290560.0 -341000.0 -1.67 1380280.0 -217000.0 -0.96 1277630.0 -260903.01886792 -1.35990959318094 1277760.0 -248178.26923077 -1.19661895417251 -2.5922 -0.981 2075142 MixCom4_000222 CN1C/2CCC1/C(=C\c3ccc(F)cc3)/C(=O)\C2=C\c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K16 compound treatment 1344180.0 -287000.0 -1.4 1427710.0 -169000.0 -0.75 1355120.0 -183413.01886792 -0.956007044130947 1237300.0 -288638.26923077 -1.3917013158792 -2.2515 -0.9701 2079989 MixCom4_000223 CC(Nc1cc(nc(n1)c2ccccc2)c3ccccc3F)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K17 compound treatment 1286720.0 -344000.0 -1.69 1306510.0 -291000.0 -1.29 1474470.0 -64063.0188679199 -0.333916848891348 1308280.0 -217658.26923077 -1.04946340105119 -2.1786 -0.9114 2075143 MixCom4_000224 OC(CNCc1ccc(cc1)C(F)(F)F)CO/N=C/C2=C(Cl)c3cc(Cl)ccc3OC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K18 compound treatment 1361150.0 -270000.0 -1.32 1412340.0 -185000.0 -0.82 1383310.0 -155223.01886792 -0.809071789804979 1265450.0 -260488.26923077 -1.25597297969424 -2.1027 -0.9753 2079990 MixCom4_000225 OC1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K19 compound treatment 1608570.0 -22600.0 -0.11 1641190.0 44100.0 0.2 1628800.0 90266.9811320801 0.470500242280225 1340890.0 -185048.26923077 -0.892230681939586 -0.1682 -0.1628 2075144 MixCom4_000226 CN(C)c1ccc(CC(C)(C)NC(=O)C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K20 compound treatment 1514400.0 -117000.0 -0.57 1539050.0 -58000.0 -0.26 1197700.0 -340833.01886792 -1.77653019900835 1123720.0 -402218.26923077 -1.93933983893029 -2.2722 -0.8404 2079991 MixCom4_000227 CN(Cc1ccccc1)c2cc(nc(n2)c3ccncc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K21 compound treatment 1699430.0 68300.0 0.33 1448180.0 -149000.0 -0.66 1634350.0 95816.9811320801 0.499428609130496 1265840.0 -260098.26923077 -1.25409255159079 -0.5404 -0.351 2075145 MixCom4_000228 CCOC(=O)c1nc(C)sc1C(=O)/C=C/N(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K22 compound treatment 1636770.0 5640.0 0.03 1569030.0 -28000.0 -0.12 1326750.0 -211783.01886792 -1.10388051576017 1447320.0 -78618.2692307699 -0.37906667411843 -0.7898 -0.6727 2079992 MixCom4_000229 Cc1cnc(CNc2cc(nc(C)n2)c3cccc(c3)C(F)(F)F)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K23 mock treatment 1706100.0 75000.0 0.37 1657760.0 60700.0 0.27 1528860.0 -9673.01886791992 -0.0504188537586982 1625440.0 99501.7307692301 0.479758592001125 0.5327 0.8033 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 K24 mock treatment 1656380.0 25300.0 0.12 1587580.0 -9490.0 -0.04 1584480.0 45946.9811320801 0.239490292946174 1553560.0 27621.7307692301 0.133181227703608 0.2271 0.7481 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L01 compound treatment 1374920.0 -256000.0 -1.25 1212800.0 -384000.0 -1.7 1432200.0 -106333.01886792 -0.55424154560503 1548240.0 22301.7307692301 0.107530259728333 -1.7023 -0.7774 2079993 MixCom4_000230 CN1CCN(CC1)c2cc(nc(C)n2)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L02 compound treatment 1406830.0 -224000.0 -1.1 1646420.0 49400.0 0.22 1472730.0 -65803.0188679199 -0.342986282822784 1501600.0 -24338.2692307699 -0.117349655002276 -0.6695 -0.5691 1676216 MixCom4_000231 O=C(N1CCN(CC1)C2c3ccccc3-c4ccccc24)c5cccs5 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L03 compound treatment 1508890.0 -122000.0 -0.6 1464210.0 -133000.0 -0.59 1484540.0 -53993.0188679199 -0.28142880309275 1346640.0 -179298.26923077 -0.864506421439993 -1.1666 -0.9427 2079995 MixCom4_000232 FC(F)(F)c1cccc(c1)c2cc(NC3CC3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L04 compound treatment 1469540.0 -162000.0 -0.79 1631300.0 34200.0 0.15 1306580.0 -231953.01886792 -1.20901297690791 1664530.0 138591.73076923 0.668235347293138 -0.5898 -0.3689 2075101 MixCom4_000233 CC(C)(C)OC(=O)NC1CCNCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L05 compound treatment 1683790.0 52700.0 0.26 1593940.0 -3130.0 -0.01 1514370.0 -24163.0188679199 -0.125945346670485 1556290.0 30351.7307692301 0.146344224427763 0.1321 0.4099 2079997 MixCom4_000234 OC(=O)CC1(CC(=O)N2CCCC2)CCCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L06 mock treatment 1332480.0 -299000.0 -1.46 1739050.0 142000.0 0.63 1363160.0 -175373.01886792 -0.914100004585691 1647850.0 121911.73076923 0.587810883791711 -0.579 -0.3005 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L07 compound treatment 1573240.0 -57900.0 -0.28 1523680.0 -73400.0 -0.33 1345600.0 -192933.01886792 -1.00562831483628 1653960.0 128021.73076923 0.617270924079104 -0.4985 -0.3968 2079998 MixCom4_000235 CS(=O)(=O)c1ccc(N2CCOCC2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L08 mock treatment 1680320.0 49200.0 0.24 1699110.0 102000.0 0.45 1402690.0 -135843.01886792 -0.708057060154846 1654640.0 128701.73076923 0.620549619233839 0.3029 0.2825 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L09 compound treatment 1613570.0 -17600.0 -0.09 1704860.0 108000.0 0.48 1391910.0 -146623.01886792 -0.764245851982939 1592110.0 66171.7307692301 0.319054313313921 -0.0265 -0.0276 2079999 MixCom4_000236 CS(=O)(=O)c1ccc(NC2CCCCC2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L10 mock treatment 1586800.0 -44300.0 -0.22 1791560.0 194000.0 0.86 1466270.0 -72263.0188679199 -0.376657859372829 1622410.0 96471.7307692301 0.46514911212047 0.367 0.3424 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L11 compound treatment 1687680.0 56600.0 0.28 1736160.0 139000.0 0.62 1414450.0 -124083.01886792 -0.646760196342381 1359040.0 -166898.26923077 -0.804718450971307 -0.279 -0.226 2080000 MixCom4_000237 CS(=O)(=O)c1ccc(NCc2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L12 compound treatment 1656350.0 25200.0 0.12 1735450.0 138000.0 0.61 1641140.0 102606.98113208 0.534820250736502 1615060.0 89121.7307692301 0.429710274786208 0.8508 0.9161 2080007 MixCom4_000238 Cc1ccccc1C(=O)N2CCc3nc4c(C)cccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L13 compound treatment 1660580.0 29500.0 0.14 1602890.0 5820.0 0.03 1612240.0 73706.9811320801 0.38418425038104 1405280.0 -120658.26923077 -0.581767180449365 -0.0138 -0.0194 2080002 MixCom4_000239 CS(=O)(=O)c1ccc(cc1)N2CCN(CC2)C(=O)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L14 compound treatment 1465060.0 -166000.0 -0.81 1724040.0 127000.0 0.56 1627750.0 89216.9811320801 0.465027308011255 1464520.0 -61418.2692307699 -0.296134973145736 -0.0403 -0.0356 2080009 MixCom4_000240 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)Cc4cc(F)cc(F)c4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L15 compound treatment 1701200.0 70100.0 0.34 1788810.0 192000.0 0.85 1577730.0 39196.9811320801 0.204307144074224 1331920.0 -194018.26923077 -0.935480528318951 0.231 0.1743 2080003 MixCom4_000241 CS(=O)(=O)c1ccc(cc1)N2CCNCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L16 compound treatment 1636210.0 5080.0 0.02 1667690.0 70600.0 0.31 1557660.0 19126.9811320801 0.099695914761624 1408000.0 -117938.26923077 -0.568652399830427 -0.0654 -0.0996 2080022 MixCom4_000242 CN1CCC(CC1)Nc2ccc3N(CCc3c2)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L17 compound treatment 1568570.0 -62600.0 -0.31 1637040.0 40000.0 0.18 1578890.0 40356.9811320801 0.210353433361848 1580800.0 54861.7307692301 0.264521898313852 0.173 0.3536 2080005 MixCom4_000243 CC(C)(C)C(=O)N1CCc2nc3ccccn3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L18 compound treatment 1799120.0 168000.0 0.82 1771040.0 174000.0 0.77 1769800.0 231266.98113208 1.20543712982764 1384490.0 -141448.26923077 -0.682008463194849 1.0585 0.5927 2080024 MixCom4_000244 COc1ccc(cc1)S(=O)(=O)N2CCCN(Cc3ccccc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L19 compound treatment 1593550.0 -37600.0 -0.18 1663550.0 66500.0 0.29 1569280.0 30746.9811320801 0.160263054004893 1242300.0 -283638.26923077 -1.36759326327086 -0.5482 -0.386 2080006 MixCom4_000245 Fc1cccc(F)c1C(=O)N2CCc3nc4ccccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L20 compound treatment 1388530.0 -243000.0 -1.19 1441380.0 -156000.0 -0.69 1355650.0 -182883.01886792 -0.953244515404705 1101540.0 -424398.26923077 -2.04628316030089 -2.4385 -0.9229 2080029 MixCom4_000246 CCCN1CCC(CC1)N(C(=O)c2cccc(c2)C(F)(F)F)c3ccc4[nH]c(cc4c3)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L21 compound treatment 1665790.0 34700.0 0.17 1645240.0 48200.0 0.21 1608960.0 70426.9811320801 0.367087846188448 1312270.0 -213668.26923077 -1.03022517506973 -0.1399 -0.1242 2080008 MixCom4_000247 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)Cc4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L22 compound treatment 1660800.0 29700.0 0.15 1364990.0 -232000.0 -1.03 1606460.0 67926.9811320801 0.354057050309948 1380020.0 -145918.26923077 -0.703561062226706 -0.6168 -0.4729 2079746 MixCom4_000248 Clc1cccc(CNC(=O)C2CCN(Cc3cccnc3)CC2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L23 mock treatment 1639680.0 8550.0 0.04 1637370.0 40300.0 0.18 1725390.0 186856.98113208 0.973958071841959 1641120.0 115181.73076923 0.555361444980883 0.8749 0.7701 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 L24 mock treatment 1599060.0 -32100.0 -0.16 1425210.0 -172000.0 -0.76 1609630.0 71096.9811320801 0.370580099483886 1336450.0 -189488.26923077 -0.913638632655793 -0.7311 -0.5821 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M01 compound treatment 1500320.0 -131000.0 -0.64 1504500.0 -92600.0 -0.41 1509600.0 -28933.0188679199 -0.150808105206664 1517890.0 -8048.26923076995 -0.0388056196042995 -0.6201 -0.7989 2075146 MixCom4_000249 COc1ccc(cc1)C(=O)NCc2ccc(cc2)N3CCN(C)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M02 compound treatment 1316110.0 -315000.0 -1.54 1379080.0 -218000.0 -0.97 1194090.0 -344443.01886792 -1.7953466682569 1579600.0 53661.7307692301 0.25873596568785 -2.0224 -0.7872 2080010 MixCom4_000250 CN1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M03 compound treatment 1319000.0 -312000.0 -1.53 1544530.0 -52500.0 -0.23 1517030.0 -21503.0188679199 -0.112080579855761 1602160.0 76221.7307692301 0.367511499056687 -0.7525 -0.4726 2075147 MixCom4_000251 CN1CCN(CC1)c2ccc(CNC(=O)c3ccc(C)c(C)c3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M04 compound treatment 1323770.0 -307000.0 -1.5 1373130.0 -224000.0 -0.99 1080350.0 -458183.01886792 -2.38819575754515 1397040.0 -128898.26923077 -0.621497251147912 -2.7534 -0.901 2080011 MixCom4_000252 CN1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M05 compound treatment 1666510.0 35400.0 0.17 1669140.0 72100.0 0.32 1420800.0 -117733.01886792 -0.61366197481099 1644090.0 118151.73076923 0.569681628230238 0.2244 0.2458 2075148 MixCom4_000253 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3ccccc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M06 compound treatment 1429220.0 -202000.0 -0.99 1521790.0 -75300.0 -0.33 1513520.0 -25013.0188679199 -0.130375817269175 1548800.0 22861.7307692301 0.110230361620467 -0.671 -0.635 2080012 MixCom4_000254 Fc1ccc(cc1)c2cc(nc(n2)c3ccncc3)N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M07 compound treatment 1458340.0 -173000.0 -0.85 1622080.0 25000.0 0.11 1559730.0 21196.9811320801 0.110485413749022 1448920.0 -77018.2692307699 -0.371352097283761 -0.4977 -0.5314 2075149 MixCom4_000255 CN1CCN(CC1)c2ccc(CNS(=O)(=O)Cc3ccc(Cl)cc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M08 compound treatment 1639810.0 8680.0 0.04 1599040.0 1970.0 0.01 1344160.0 -194373.01886792 -1.01313405326229 1609120.0 83181.7307692301 0.401069908287498 -0.2804 -0.2571 2080013 MixCom4_000256 CN(C)CCNc1cc(nc(C)n1)c2ccccc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M09 compound treatment 1626750.0 -4380.0 -0.02 1547160.0 -49900.0 -0.22 1636870.0 98336.9811320801 0.512563651376024 1499300.0 -26638.2692307699 -0.128439359202113 0.0707 0.1233 2075150 MixCom4_000257 OC(CNCc1ccco1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M10 compound treatment 1544570.0 -86600.0 -0.42 1632020.0 35000.0 0.15 1597400.0 58866.9811320801 0.306833446046263 1363750.0 -162188.26923077 -0.782008665414249 -0.3719 -0.39 2080014 MixCom4_000258 Cc1nc(cc(n1)c2ccccc2F)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M11 compound treatment 1702630.0 71500.0 0.35 1711620.0 115000.0 0.51 1710900.0 172366.98113208 0.898431578930172 1676670.0 150731.73076923 0.726769699026191 1.2415 0.9478 1478188 MixCom4_000259 O=C(CN1C(=O)c2ccccc2C1=O)N3CCCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M12 compound treatment 1627300.0 -3830.0 -0.02 1601090.0 4020.0 0.02 1371760.0 -166773.01886792 -0.86927406676365 1498720.0 -27218.2692307699 -0.131235893304681 -0.5007 -0.5693 2080015 MixCom4_000260 Cc1nc(cc(n1)c2ccccc2F)N3CCc4ccccc4C3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M13 compound treatment 1441760.0 -189000.0 -0.93 1221760.0 -375000.0 -1.66 1450360.0 -88173.0188679199 -0.459585844343604 1614670.0 88731.7307692301 0.427829846682757 -1.3114 -0.6538 2075151 MixCom4_000261 COc1cc2CCN(Cc2cc1OC)C(=O)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M14 compound treatment 1666170.0 35000.0 0.17 1637440.0 40400.0 0.18 1474240.0 -64293.0188679199 -0.33511568211217 1238200.0 -287738.26923077 -1.3873618664097 -0.686 -0.4735 2080016 MixCom4_000262 CCN(CC)c1cc(nc(n1)c2ccccc2)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M15 compound treatment 1665520.0 34400.0 0.17 1410080.0 -187000.0 -0.83 1332730.0 -205803.01886792 -1.0727108520188 1372560.0 -153378.26923077 -0.739530276718351 -1.2366 -0.796 2075152 MixCom4_000263 O=C(COc1ccccc1)Nc2ccc3N4CCCC4COc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M16 compound treatment 1496660.0 -134000.0 -0.66 1599580.0 2510.0 0.01 1638740.0 100206.98113208 0.522310686693142 1470920.0 -55018.2692307699 -0.265276665807059 -0.1949 -0.2212 2080017 MixCom4_000264 CCN(CC)c1cc(nc(n1)c2cccnc2)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M17 compound treatment 1415300.0 -216000.0 -1.06 1473820.0 -123000.0 -0.55 1531010.0 -7523.01886791992 -0.039212369303188 1367760.0 -158178.26923077 -0.762674007222359 -1.2023 -0.8507 2075153 MixCom4_000265 OC(CO/N=C/C1=C(Cl)c2cc(Cl)ccc2OC1)CN3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M18 compound treatment 1635360.0 4230.0 0.02 1333040.0 -264000.0 -1.17 1273940.0 -264593.01886792 -1.37914304789761 1190630.0 -335308.26923077 -1.61672587892546 -2.073 -0.8544 2080018 MixCom4_000266 Fc1ccccc1c2cc(NCc3ccccc3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M19 compound treatment 1584830.0 -46300.0 -0.23 1363440.0 -234000.0 -1.04 1548450.0 9916.98113208008 0.0516904627452293 1570440.0 44501.7307692301 0.214570013309369 -0.4982 -0.4599 1173337 MixCom4_000267 Clc1cccc(Cl)c1c2noc(CN3CCOCC3)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M20 compound treatment 1497040.0 -134000.0 -0.66 1060180.0 -537000.0 -2.38 1167230.0 -371303.01886792 -1.93534953917551 1482030.0 -43908.2692307699 -0.211708572911324 -2.5921 -0.8242 2080019 MixCom4_000268 Fc1ccccc1c2cc(NCC=C)nc(n2)c3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M21 compound treatment 1359520.0 -272000.0 -1.33 1131220.0 -466000.0 -2.07 1089500.0 -449033.01886792 -2.34050304462984 1048000.0 -477938.26923077 -2.30443218763101 -4.02 -0.9801 2075154 MixCom4_000269 CN(C)/C=C/C(=O)c1csc(n1)c2ccc(cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M22 compound treatment 1727470.0 96300.0 0.47 1597120.0 51.2 0.0 1633680.0 95146.9811320801 0.495936355835058 1511200.0 -14738.2692307699 -0.0710621939942603 0.4483 0.6516 2080020 MixCom4_000270 Cc1nc(cc(n1)c2cccc(c2)C(F)(F)F)N3CCC4(CC3)OCCO4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M23 mock treatment 1649400.0 18300.0 0.09 1654110.0 57000.0 0.25 1661810.0 123276.98113208 0.642558871059942 1601320.0 75381.7307692301 0.363461346218486 0.6742 0.8583 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 M24 mock treatment 1662930.0 31800.0 0.16 1442270.0 -155000.0 -0.69 1522210.0 -16323.0188679199 -0.0850807707955087 1405440.0 -120498.26923077 -0.580995722765898 -0.5985 -0.6529 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N01 compound treatment 1162880.0 -468000.0 -2.29 1333640.0 -263000.0 -1.17 1217080.0 -321453.01886792 -1.67551546935821 1480960.0 -44978.2692307699 -0.216867696169509 -2.676 -0.8696 2080021 MixCom4_000271 Cc1nc(cc(n1)c2cccc(c2)C(F)(F)F)N3CCC(O)CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N02 compound treatment 1370300.0 -261000.0 -1.28 1579360.0 -17700.0 -0.08 1651110.0 112576.98113208 0.586787064699961 1617600.0 91661.7307692301 0.441957165511245 -0.1631 -0.1106 1188987 MixCom4_000272 CC(C)(C)C(=O)N1CCN(CC1)C2c3ccccc3-c4ccccc24 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N03 compound treatment 1412990.0 -218000.0 -1.07 1102200.0 -495000.0 -2.19 960640.0 -577893.01886792 -3.01216238739125 1080750.0 -445188.26923077 -2.14652444304637 -4.2104 -0.9501 2080023 MixCom4_000273 FC(F)(F)c1cccc(c1)c2cc(NC3CC3)nc(n2)c4ccncc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N04 compound treatment 1534290.0 -96800.0 -0.47 1567540.0 -29500.0 -0.13 1543310.0 4776.98113208008 0.0248991464190329 1414080.0 -111858.26923077 -0.539337007858684 -0.5596 -0.7664 1627910 MixCom4_000274 CN1CCN(CC1)c2ccc(NC(=O)c3ccccc3Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N05 compound treatment 1594720.0 -36400.0 -0.18 1540030.0 -57000.0 -0.25 1347800.0 -190733.01886792 -0.994161214463196 1590810.0 64871.7307692301 0.312786219635752 -0.5562 -0.5116 2080025 MixCom4_000275 OC(=O)CC1(CC(=O)N2CCc3ccccc3C2)CCCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N06 mock treatment 1598510.0 -32600.0 -0.16 1656480.0 59400.0 0.26 1364540.0 -173993.01886792 -0.906907005260759 1673760.0 147821.73076923 0.712738812408136 -0.0452 -0.0378 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N07 compound treatment 1559750.0 -71400.0 -0.35 1516200.0 -80900.0 -0.36 1574520.0 35986.9811320801 0.187575602166229 1585310.0 59371.7307692301 0.286267361766576 -0.117 -0.193 2080026 MixCom4_000276 CS(=O)(=O)c1ccc(N2CCCCC2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N08 mock treatment 1465360.0 -166000.0 -0.81 1664010.0 66900.0 0.3 1468250.0 -70283.0188679199 -0.366337469037057 1553780.0 27841.7307692301 0.134241982018375 -0.3732 -0.3937 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N09 compound treatment 1584070.0 -47100.0 -0.23 1788550.0 191000.0 0.85 1322050.0 -216483.01886792 -1.12837841201175 1470080.0 -55858.2692307699 -0.26932681864526 -0.3894 -0.2675 2080027 MixCom4_000277 CC1CN(CC(C)O1)c2ccc(cc2F)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N10 mock treatment 1644830.0 13700.0 0.07 1677940.0 80900.0 0.36 1374780.0 -163753.01886792 -0.853532865342422 1513460.0 -12478.2692307699 -0.06016535421529 -0.244 -0.2623 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N11 compound treatment 1553050.0 -78100.0 -0.38 1497570.0 -99500.0 -0.44 1680030.0 141496.98113208 0.737527311422451 1550400.0 24461.7307692301 0.117944938455136 0.0161 0.017 2080028 MixCom4_000278 CS(=O)(=O)c1ccc(NCc2ccco2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N12 compound treatment 1732190.0 101000.0 0.49 1534620.0 -62400.0 -0.28 1346750.0 -191783.01886792 -0.999634148732166 1635420.0 109481.73076923 0.527878265007374 -0.1271 -0.1005 2080032 MixCom4_000279 CCC(=O)N1CCc2nc3c(C)cccn3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N13 compound treatment 1533660.0 -97500.0 -0.48 1479440.0 -118000.0 -0.52 1576290.0 37756.9811320801 0.196801405648207 1549860.0 23921.7307692301 0.115341268773436 -0.3432 -0.4621 2080030 MixCom4_000280 CS(=O)(=O)c1ccc(cc1)N2CCN(CC2)C(=O)c3c(F)cccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N14 compound treatment 1752050.0 121000.0 0.59 1752000.0 155000.0 0.69 1476380.0 -62153.0188679199 -0.323961320840174 1663810.0 137871.73076923 0.664763787717537 0.8098 0.6921 2080034 MixCom4_000281 CC(C)CC(=O)N1CCc2nc3cccc(C)n3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N15 compound treatment 1750040.0 119000.0 0.58 1703300.0 106000.0 0.47 1600440.0 61906.9811320801 0.322678893834519 1709330.0 183391.73076923 0.884243498663877 1.13 0.9395 2080031 MixCom4_000282 CS(=O)(=O)c1ccc(N2CCNCC2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N16 compound treatment 1724120.0 93000.0 0.46 1780420.0 183000.0 0.81 1527720.0 -10813.0188679199 -0.0563608966792943 1269090.0 -256848.26923077 -1.23842231739537 -0.0133 -0.0086 2080036 MixCom4_000283 CN1CCC(CC1)N(C(=O)C2CC2)c3ccc4N(CCc4c3)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N17 compound treatment 1694170.0 63000.0 0.31 1646920.0 49900.0 0.22 1440530.0 -98003.0188679199 -0.510822933737867 1405470.0 -120468.26923077 -0.580851074450248 -0.2811 -0.3262 2080033 MixCom4_000284 Clc1ccc(C(=O)N2CCc3nc4ccccn4c(=O)c3C2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N18 compound treatment 1664920.0 33800.0 0.17 1808160.0 211000.0 0.94 1674160.0 135626.98113208 0.706931002699733 1333920.0 -192018.26923077 -0.925837307275614 0.4413 0.2935 2080038 MixCom4_000285 COc1cccc(OC)c1C(=O)N2CCCN(Cc3ccccc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N19 compound treatment 1711840.0 80700.0 0.39 1715530.0 118000.0 0.53 1604880.0 66346.9811320801 0.345821587314736 1660800.0 134861.73076923 0.650250740047315 0.9582 0.9707 2080035 MixCom4_000286 Clc1ccc(cc1)C(=O)N2CCc3nc4ccccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N20 compound treatment 1668360.0 37200.0 0.18 1681170.0 84100.0 0.37 1541650.0 3116.98113208008 0.0162466979557088 1548280.0 22341.7307692301 0.1077231241492 0.3396 0.7913 2080051 MixCom4_000287 CCCN1CCC(CC1)N(C2CC2)C(=O)C(c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N21 compound treatment 1643950.0 12800.0 0.06 1474400.0 -123000.0 -0.54 1636570.0 98036.9811320801 0.510999955870604 1269970.0 -255968.26923077 -1.2341793001363 -0.6022 -0.4171 2080037 MixCom4_000288 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)C4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N22 compound treatment 1576800.0 -54300.0 -0.27 1561940.0 -35100.0 -0.16 1627420.0 88886.9811320801 0.463307242955293 1524280.0 -1658.26923076995 -0.00799552837083915 0.0168 0.0303 2080053 MixCom4_000289 COc1ccc(cc1)c2cnc(NCCN(C)C)nc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N23 mock treatment 1693680.0 62600.0 0.31 1716280.0 119000.0 0.53 1692480.0 153946.98113208 0.802420674897382 1677960.0 152021.73076923 0.732989576599143 1.1851 0.9506 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 N24 mock treatment 1607640.0 -23500.0 -0.11 1350410.0 -247000.0 -1.09 1525980.0 -12553.0188679199 -0.0654303306107304 1385000.0 -140938.26923077 -0.679549441828798 -0.9769 -0.7546 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O01 compound treatment 935580.0 -696000.0 -3.4 1020590.0 -576000.0 -2.56 1034050.0 -504483.01886792 -2.62952609721497 1190260.0 -335678.26923077 -1.61850987481848 -5.1041 -0.9706 2075155 MixCom4_000290 CN1CCN(CC1)c2ccc(CNC(=O)c3csc4ccccc34)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O02 compound treatment 1540160.0 -91000.0 -0.45 1522790.0 -74300.0 -0.33 1658520.0 119986.98113208 0.625410343683836 1684280.0 158341.73076923 0.763462155096087 0.3072 0.2714 2080039 MixCom4_000291 OC1CCN(CC1)c2cc(nc(n2)c3ccccc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O03 compound treatment 1592540.0 -38600.0 -0.19 1579690.0 -17400.0 -0.08 1581760.0 43226.9811320801 0.225312787030366 1566880.0 40941.7307692301 0.19740507985223 0.0784 0.2164 2075156 MixCom4_000292 OC(CN1CCC(CC1)C(=O)c2ccc(F)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O04 compound treatment 724190.0 -907000.0 -4.44 890320.0 -707000.0 -3.13 660260.0 -878273.01886792 -4.5778385737848 1298260.0 -227678.26923077 -1.09777593847831 -6.6239 -0.9214 2080040 MixCom4_000293 OC1CCN(CC1)c2cc(nc(n2)c3cccnc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O05 compound treatment 1639130.0 8000.0 0.04 1542480.0 -54600.0 -0.24 1585710.0 47176.9811320801 0.245901444518396 1657320.0 131381.73076923 0.63347153543191 0.3382 0.4682 2075157 MixCom4_000294 CN1CCN(CC1)c2ccc(CNS(=O)(=O)c3ccccc3C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O06 compound treatment 1364800.0 -266000.0 -1.3 1261410.0 -336000.0 -1.49 1493660.0 -44873.0188679199 -0.233892459727981 1301380.0 -224558.26923077 -1.0827325136507 -2.0542 -0.906 2080041 MixCom4_000295 CN(Cc1ccccc1)c2cc(nc(n2)c3ccncc3)c4ccc(F)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O07 compound treatment 1372700.0 -258000.0 -1.26 1222260.0 -375000.0 -1.66 1228000.0 -310533.01886792 -1.61859695296093 1236100.0 -289838.26923077 -1.39748724850521 -2.9714 -0.9941 2075158 MixCom4_000296 CN1CCN(CC1)c2ccc(CNS(=O)(=O)Cc3cccc(c3)C(F)(F)F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O08 compound treatment 1491730.0 -139000.0 -0.68 1571530.0 -25500.0 -0.11 1476700.0 -61833.0188679199 -0.322293378967726 1458910.0 -67028.2692307699 -0.323184208172295 -0.7204 -0.8695 2080042 MixCom4_000297 Cc1nc(NCCC#N)cc(n1)c2ccccc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O09 compound treatment 1636840.0 5710.0 0.03 1736820.0 140000.0 0.62 1390040.0 -148493.01886792 -0.773992887300057 1545440.0 19501.7307692301 0.0940297502676618 -0.0161 -0.0162 2075159 MixCom4_000298 Cn1cccc1CNCC(O)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O10 compound treatment 1664740.0 33600.0 0.16 1563960.0 -33100.0 -0.15 1587200.0 48666.9811320801 0.253667798861982 1567240.0 41301.7307692301 0.19914085964003 0.2352 0.6021 2080043 MixCom4_000299 CN(Cc1ccccc1)c2cc(nc(C)n2)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O11 compound treatment 1667910.0 36800.0 0.18 1691130.0 94100.0 0.42 1655680.0 117146.98113208 0.610607359565859 1722460.0 196521.73076923 0.947551244813382 1.0776 0.8867 1677557 MixCom4_000300 CC1CCN(CC1)C(=O)CN2C(=O)c3ccccc3C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O12 compound treatment 1750560.0 119000.0 0.58 1654330.0 57300.0 0.25 1697940.0 159406.98113208 0.830879933096027 1598290.0 72351.7307692301 0.348851866337831 1.0091 0.9143 2080044 MixCom4_000301 Cc1nc(NCCc2ccccc2)cc(n1)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O13 compound treatment 1475420.0 -156000.0 -0.76 1555940.0 -41100.0 -0.18 1559760.0 21226.9811320801 0.110641783299564 1376750.0 -149188.26923077 -0.719327728632561 -0.7765 -0.7262 2075160 MixCom4_000302 COc1cc2CCN(Cc2cc1OC)C(=O)C3CCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O14 compound treatment 1629820.0 -1310.0 -0.01 1636450.0 39400.0 0.17 1584110.0 45576.9811320801 0.237561735156156 1644390.0 118451.73076923 0.571128111386739 0.4885 0.7599 2080045 MixCom4_000303 Fc1ccccc1c2cc(nc(n2)c3ccccc3)N4CCOCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O15 compound treatment 1720380.0 89300.0 0.44 1758440.0 161000.0 0.72 1576170.0 37636.9811320801 0.196175927446039 1666530.0 140591.73076923 0.677878568336475 1.0132 0.9246 2075161 MixCom4_000304 Cc1ccc(F)cc1S(=O)(=O)Nc2ccc3N4CCCC4COc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O16 compound treatment 1733890.0 103000.0 0.5 1637170.0 40100.0 0.18 1752770.0 214236.98113208 1.11667134830329 1344440.0 -181498.26923077 -0.875113964587664 0.4611 0.3042 2080046 MixCom4_000305 Fc1ccccc1c2cc(NCc3ccncc3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O17 compound treatment 1732810.0 102000.0 0.5 1595710.0 -1360.0 -0.01 1633090.0 94556.9811320801 0.492861088007732 1677030.0 151091.73076923 0.728505478813992 0.8565 0.8475 2075162 MixCom4_000306 OC(CNCc1ccc(F)cc1)CO/N=C/C2=C(Cl)c3cc(Cl)ccc3OC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O18 compound treatment 1612710.0 -18400.0 -0.09 1569560.0 -27500.0 -0.12 1463580.0 -74953.0188679199 -0.390678995738095 1220240.0 -305698.26923077 -1.47395799137886 -1.0384 -0.6776 2080047 MixCom4_000307 Fc1ccccc1c2cc(NCc3ccco3)nc(n2)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O19 compound treatment 1372830.0 -258000.0 -1.26 1289950.0 -307000.0 -1.36 1135630.0 -402903.01886792 -2.10005879907975 1170240.0 -355698.26923077 -1.71503851746228 -3.2205 -0.9798 1606129 MixCom4_000308 Clc1cccc(Cl)c1c2noc(CN3CCCCC3)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O20 compound treatment 1215690.0 -415000.0 -2.03 1620510.0 23400.0 0.1 1491160.0 -47373.0188679199 -0.246923255606481 1328990.0 -196948.26923077 -0.949607847147439 -1.5627 -0.6916 2080048 MixCom4_000309 CN1CCN(CC1)c2cc(nc(n2)c3ccncc3)c4ccccc4F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O21 compound treatment 1429730.0 -201000.0 -0.99 1513210.0 -83900.0 -0.37 1543790.0 5256.98113208008 0.027401059227705 1535160.0 9221.73076923005 0.0444635941049118 -0.6428 -0.6095 2075163 MixCom4_000310 CN(C)/C=C/C(=O)c1cc(no1)c2ccc(Cl)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O22 compound treatment 1476530.0 -155000.0 -0.76 1160810.0 -436000.0 -1.93 1149330.0 -389203.01886792 -2.02865003766557 1296500.0 -229438.26923077 -1.10626197299644 -2.9131 -0.9375 2080049 MixCom4_000311 CCN(CC)c1cc(nc(C)n1)c2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O23 mock treatment 1672580.0 41500.0 0.2 1620170.0 23100.0 0.1 1708110.0 169576.98113208 0.883889210729765 1687610.0 161671.73076923 0.779518118133242 0.9843 0.8201 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 O24 mock treatment 1537860.0 -93300.0 -0.46 1323680.0 -273000.0 -1.21 1567450.0 28916.9811320801 0.150724511421831 1356180.0 -169758.26923077 -0.818508257063278 -1.1683 -0.7587 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P01 compound treatment 719250.0 -912000.0 -4.46 557490.0 -1040000.0 -4.61 900000.0 -638533.01886792 -3.32823737222015 940750.0 -585188.26923077 -2.82154991607993 -7.6111 -0.9809 2080050 MixCom4_000312 Cc1nc(NCc2ccccc2)cc(n1)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P02 compound treatment 1470460.0 -161000.0 -0.79 1354180.0 -243000.0 -1.08 1351570.0 -186963.01886792 -0.974510774278418 1470420.0 -55518.2692307699 -0.267687471067893 -1.5528 -0.928 2075102 MixCom4_000313 NC(=O)C1=CN(Cc2ccc(Cl)cc2)CCC1C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P03 compound treatment 1023740.0 -607000.0 -2.97 1149690.0 -447000.0 -1.98 1071570.0 -466963.01886792 -2.43395991267044 1105600.0 -420338.26923077 -2.02670742158292 -4.7084 -0.986 2080052 MixCom4_000314 COc1ccc(cc1)c2cnc(nc2)N3CCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P04 compound treatment 1625400.0 -5730.0 -0.03 1524770.0 -72300.0 -0.32 1529880.0 -8653.01886791992 -0.0451022890402701 1553140.0 27201.7307692301 0.131156151284508 -0.1313 -0.3746 1443609 MixCom4_000315 CN1CCN(CC1)c2ccc(NS(=O)(=O)c3ccccc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P05 compound treatment 1690880.0 59800.0 0.29 1714660.0 118000.0 0.52 1576350.0 37816.9811320801 0.197114144749291 1600100.0 74161.7307692301 0.35757898138205 0.6843 0.9452 2080054 MixCom4_000316 Fc1ccc(CC(=O)N2CCNC(=O)CC2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P06 mock treatment 1775960.0 145000.0 0.71 1763550.0 166000.0 0.74 1696450.0 157916.98113208 0.823113578752441 1705980.0 180041.73076923 0.868091103416288 1.5691 0.9967 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P07 compound treatment 1614340.0 -16800.0 -0.08 1572520.0 -24500.0 -0.11 1633280.0 94746.9811320801 0.493851428494498 1496840.0 -29098.2692307699 -0.140300521085417 0.0813 0.153 2080055 MixCom4_000317 CN1CCN(CC1)c2ccc(cc2F)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P08 mock treatment 1584100.0 -47000.0 -0.23 1613120.0 16100.0 0.07 1619040.0 80506.9811320801 0.419628015170561 1577030.0 51091.7307692301 0.246344426647163 0.2535 0.4669 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P09 compound treatment 1524480.0 -107000.0 -0.52 1612450.0 15400.0 0.07 1606240.0 67706.9811320801 0.35291034027264 1490110.0 -35828.2692307699 -0.172749959896244 -0.1367 -0.2082 2080056 MixCom4_000318 CN(C)CCNc1ccc(cc1)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P10 compound treatment 1646690.0 15600.0 0.08 1664530.0 67500.0 0.3 1652540.0 114006.98113208 0.594240679942463 1526600.0 661.730769230053 0.00319060803943127 0.4864 0.7263 2080057 MixCom4_000319 CC(C)CC(=O)N1CCc2nc3c(C)cccn3c(=O)c2C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P11 compound treatment 1008280.0 -623000.0 -3.05 996890.0 -600000.0 -2.66 950880.0 -587653.01886792 -3.06303461450091 1002760.0 -523178.26923077 -2.52256184763128 -5.6475 -0.9965 2080058 MixCom4_000320 CS(=O)(=O)c1ccc(cc1)N2CCc3ccccc3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P12 compound treatment 1682680.0 51600.0 0.25 1655250.0 58200.0 0.26 1629050.0 90516.9811320801 0.471803321868075 1628800.0 102861.73076923 0.49595920335393 0.739 0.955 2080059 MixCom4_000321 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)c4cccc(c4)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P13 compound treatment 1556510.0 -74600.0 -0.37 1596130.0 -939.0 0.0 1622880.0 84346.9811320801 0.439643317639937 1521700.0 -4238.26923076995 -0.0204352835167433 0.025 0.0436 2080060 MixCom4_000322 CS(=O)(=O)c1ccc(cc1)N2CCN(CC2)C(=O)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P14 compound treatment 1257250.0 -374000.0 -1.83 1171380.0 -426000.0 -1.89 1194270.0 -344263.01886792 -1.79440845095365 1088050.0 -437888.26923077 -2.1113266862382 -3.8115 -0.9979 2080061 MixCom4_000323 Cc1cccc2nc3CCN(Cc3c(=O)n12)C(=O)c4ccc(cc4)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P15 compound treatment 1659790.0 28700.0 0.14 1649280.0 52200.0 0.23 1499260.0 -39273.0188679199 -0.20470347696014 1603610.0 77671.7307692301 0.374502834313106 0.2708 0.5358 2080062 MixCom4_000324 CC(=O)N1CCCN(CC1)c2ccc(cc2)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P16 compound treatment 1677180.0 46100.0 0.23 1638150.0 41100.0 0.18 1644890.0 106356.98113208 0.554366444554253 1493320.0 -32618.2692307699 -0.157272590121689 0.4023 0.6237 2080063 MixCom4_000325 CN1CCC(CC1)N(C(=O)c2ccc(cc2)C(F)(F)F)c3ccc4N(CCc4c3)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P17 compound treatment 1612180.0 -18900.0 -0.09 1673920.0 76900.0 0.34 1598610.0 60076.9811320801 0.313140351251457 1663740.0 137801.73076923 0.66442627498102 0.6128 0.7519 2080064 MixCom4_000326 O=C(Cc1ccccc1)N2CCc3nc4ccccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P18 compound treatment 1440710.0 -190000.0 -0.93 1354480.0 -243000.0 -1.08 1018330.0 -520203.01886792 -2.71146374169898 1097070.0 -428868.26923077 -2.06783575933275 -3.3935 -0.9184 2080065 MixCom4_000327 COc1cccc(OC)c1CN2CCC(CC2)NCCc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P19 compound treatment 1656960.0 25800.0 0.13 1331270.0 -266000.0 -1.18 1631360.0 92826.9811320801 0.48384377725981 1439590.0 -86348.2692307699 -0.416337723450926 -0.4924 -0.3657 2080066 MixCom4_000328 Cc1ccccc1C(=O)N2CCc3nc4ccccn4c(=O)c3C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P20 compound treatment 1647440.0 16300.0 0.08 1746990.0 150000.0 0.66 1633990.0 95456.9811320801 0.497552174523992 1659620.0 133681.73076923 0.644561239631747 0.9434 0.8949 2080067 MixCom4_000329 O=C(NCCN1CCOCC1)c2cccc3cc[nH]c23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P21 compound treatment 1744090.0 113000.0 0.55 1684370.0 87300.0 0.39 1706400.0 167866.98113208 0.874976146348871 1551370.0 25431.7307692301 0.122621900661155 0.9688 0.8714 2080068 MixCom4_000330 Cc1cccn2c(=O)c3CN(CCc3nc12)C(=O)Cc4cc(F)cc(F)c4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P22 compound treatment 1565550.0 -65600.0 -0.32 1595800.0 -1270.0 -0.01 1611400.0 72866.9811320801 0.379805902965864 1523210.0 -2728.26923076995 -0.0131546516290242 0.0201 0.0403 2080069 MixCom4_000331 CN1CCN(CC1)c2nc3ccccc3n4ccnc24 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P23 mock treatment 1633090.0 1960.0 0.01 1580800.0 -16300.0 -0.07 1620880.0 82346.9811320801 0.429218680937137 1563410.0 37471.7307692301 0.180674091342041 0.2737 0.5806 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.1306 P24 mock treatment 1595610.0 -35500.0 -0.17 1502210.0 -94900.0 -0.42 1398720.0 -139813.01886792 -0.728749964009904 1399610.0 -126328.26923077 -0.609105712107224 -0.9662 -0.9173 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A01 compound treatment 1456430.0 -195000.0 -0.95 1476710.0 8690.0 0.04 1338280.0 -136278.4375 -0.710326600681378 1085320.0 -530399.03225806 -2.55737755461814 -2.0915 -0.7415 2069431 Maybridge1_000177 OCCN1CCN(CC1)c2ncc(Cl)cc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A02 compound treatment 1404580.0 -247000.0 -1.21 1463770.0 -4250.0 -0.02 1410190.0 -64368.4375 -0.335508788032199 1332660.0 -283059.03225806 -1.36480040818871 -1.4633 -0.7897 1539016 Maybridge1_000178 CCOC(=O)C1CCN(CC1)c2ncnc3scc(c4ccccc4)c23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A03 compound treatment 1160090.0 -491000.0 -2.4 1251610.0 -216000.0 -0.96 1205520.0 -269038.4375 -1.40231398501325 1210110.0 -405609.03225806 -1.95568877761915 -3.3608 -0.9509 2069432 Maybridge1_000179 c1csc(c1)c2cc3ccccc3[nH]2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A04 compound treatment 1373990.0 -277000.0 -1.36 1423690.0 -44300.0 -0.2 1408860.0 -65698.4375 -0.342441171439561 1453660.0 -162059.03225806 -0.781385535066843 -1.3388 -0.829 1705599 Maybridge1_000180 CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A05 compound treatment 1241310.0 -410000.0 -2.01 1440560.0 -27500.0 -0.12 1476560.0 2001.5625 0.0104327809502242 1450920.0 -164799.03225806 -0.794596747896214 -1.4562 -0.6737 2069433 Maybridge1_000181 [O-][N+](=O)c1cccnc1N2CCCNCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A06 compound treatment 1401030.0 -250000.0 -1.22 1401360.0 -66700.0 -0.3 1477920.0 3361.5625 0.0175215339081283 1474050.0 -141669.03225806 -0.683072896530026 -1.093 -0.7626 1502090 Maybridge1_000182 CCc1cccc(C)c1NC(=O)N2CCN(CC2)C(=O)OC(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A07 compound treatment 1402400.0 -249000.0 -1.22 1410100.0 -57900.0 -0.26 1514360.0 39801.5625 0.207458414633147 1482930.0 -132789.03225806 -0.640256995097612 -0.9539 -0.674 2069434 Maybridge1_000183 CC(C)(C)OC(=O)NCCNC(=O)Nc1cccc(Cl)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A08 compound treatment 1298330.0 -353000.0 -1.73 1335620.0 -132000.0 -0.59 1437040.0 -37518.4375 -0.195558040297107 1255840.0 -359879.03225806 -1.73519652846326 -2.1227 -0.8405 2069435 Maybridge1_000184 CC1CCCC(C)N1C(=S)Nc2ccc(C)cc2C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A09 compound treatment 1425070.0 -226000.0 -1.11 1377920.0 -90100.0 -0.4 1431630.0 -42928.4375 -0.223756682578181 1359710.0 -256009.03225806 -1.23437584357758 -1.4825 -0.8618 2069436 Maybridge1_000185 CC(=O)Nc1cc(ccc1n2cc(C)c(n2)C(F)(F)F)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A10 compound treatment 1324170.0 -327000.0 -1.6 1415450.0 -52600.0 -0.23 1456160.0 -18398.4375 -0.0958985134183373 1465760.0 -149959.03225806 -0.723044047754656 -1.3265 -0.7475 1564219 Maybridge1_000186 Cc1ccc(cc1)c2csc3ncnc(N4CCc5ccccc5C4)c23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A11 compound treatment 1330310.0 -321000.0 -1.57 1202530.0 -265000.0 -1.18 1358760.0 -115798.4375 -0.603578320844705 1324640.0 -291079.03225806 -1.40346972457248 -2.3777 -0.9558 2069437 Maybridge1_000187 [O-][N+](=O)c1ccc(nc1)N2CCCN(CC2)C(=S)Nc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A12 compound treatment 1534880.0 -116000.0 -0.57 1325800.0 -142000.0 -0.63 1516360.0 41801.5625 0.217883051335947 1535620.0 -80099.0322580601 -0.38620633671091 -0.6845 -0.7139 1073786 Maybridge1_000188 CCOC(=O)c1c(N)sc2CN(C)CCc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A13 compound treatment 1457390.0 -194000.0 -0.95 1319290.0 -149000.0 -0.66 1444200.0 -30358.4375 -0.158237840901082 1375410.0 -240309.03225806 -1.15867655838739 -1.4628 -0.8897 2069438 Maybridge1_000189 CC(C)(C)c1ccc(cc1)C(=O)NCCNc2nccc(n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A14 compound treatment 1539440.0 -112000.0 -0.55 1390150.0 -77900.0 -0.35 1477490.0 2931.5625 0.0152802370170263 1469650.0 -146069.03225806 -0.704287982825367 -0.791 -0.8267 2069439 Maybridge1_000190 CC(C)(C)OC(=O)NCCCNC(=S)Nc1ccc2OCCOc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A15 compound treatment 1233770.0 -418000.0 -2.04 1332260.0 -136000.0 -0.6 1586950.0 112391.5625 0.585820603761279 1506690.0 -109029.03225806 -0.525695529102773 -1.2926 -0.5692 1122662 Maybridge1_000191 Clc1ccc(cc1)S(=O)(=O)N2CCCN(Cc3ccc(Cl)cc3Cl)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A16 compound treatment 584270.0 -1070000.0 -5.22 535600.0 -932000.0 -4.14 574050.0 -900508.4375 -4.69373665437186 714050.0 -901669.03225806 -4.34749689299792 -9.1989 -0.996 2069440 Maybridge1_000192 CCCCCc1ccc(NC(=O)NNc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A17 compound treatment 1484420.0 -167000.0 -0.82 1286250.0 -182000.0 -0.81 1450730.0 -23828.4375 -0.12420140206644 1495550.0 -120169.03225806 -0.579408270314158 -1.1633 -0.9007 2069441 Maybridge1_000193 CC(=O)c1ccc(OCC(O)CN2CCCN(CC2)C(=O)c3cccs3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A18 compound treatment 1537870.0 -113000.0 -0.56 1279920.0 -188000.0 -0.83 1469140.0 -5418.4375 -0.0282426212171644 1491130.0 -124589.03225806 -0.600719788819932 -1.0092 -0.8635 1083184 Maybridge1_000194 COc1ccccc1NC(=S)NCc2ccco2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A19 compound treatment 1407290.0 -244000.0 -1.19 1168360.0 -300000.0 -1.33 1404580.0 -69978.4375 -0.364749893983553 1187170.0 -428549.03225806 -2.06629652298622 -2.4771 -0.8988 1522108 Maybridge1_000195 COc1ccccc1C2CCN(CC2)C(=S)Nc3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A20 compound treatment 1399900.0 -251000.0 -1.23 1292970.0 -175000.0 -0.78 1385920.0 -88638.4375 -0.462011754420679 1401860.0 -213859.03225806 -1.03114496008926 -1.7499 -0.95 1083188 Maybridge1_000196 CCOC(=O)c1cc(C)nc2ccc(Br)cc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A21 compound treatment 566160.0 -1090000.0 -5.31 726140.0 -742000.0 -3.29 851890.0 -622668.4375 -3.24554612361886 771640.0 -844079.03225806 -4.06982034305505 -7.9578 -0.9787 1170678 Maybridge1_000197 COc1ccc(OCC(O)CNC2CCN(CC2)c3ncnc4scc(c5ccccc5)c34)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A22 compound treatment 1278150.0 -373000.0 -1.83 1156360.0 -312000.0 -1.38 1256160.0 -218398.4375 -1.13836218369835 1338350.0 -277369.03225806 -1.33736544432041 -2.842 -0.9847 1914814 Maybridge1_000198 COc1ccc(/N=C/c2ccccc2O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A23 mock treatment 1505040.0 -146000.0 -0.72 1348540.0 -119000.0 -0.53 1464860.0 -9698.4375 -0.0505513437611567 1614240.0 -1479.03225806006 -0.0071313174973492 -0.6517 -0.7305 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 A24 mock treatment 1538150.0 -113000.0 -0.55 1408740.0 -59300.0 -0.26 1430570.0 -43988.4375 -0.229281740030665 1584890.0 -30829.0322580601 -0.148645586308313 -0.5973 -0.8899 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B01 compound treatment 1423950.0 -227000.0 -1.11 1395160.0 -72900.0 -0.32 1371250.0 -103308.4375 -0.538476464635718 1190080.0 -425639.03225806 -2.05226563636817 -2.0133 -0.8328 1118509 Maybridge1_000199 Clc1c(sc2ccccc12)C(=O)N(CCC#N)Cc3ccncc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B02 compound treatment 1412800.0 -239000.0 -1.17 1534630.0 66600.0 0.3 1449830.0 -24728.4375 -0.1288924885827 1377960.0 -237759.03225806 -1.14638145155713 -1.0736 -0.6438 2069442 Maybridge1_000200 Clc1c(sc2ccccc12)C(=O)NNC(=S)Nc3cc(Cl)ccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B03 compound treatment 1292340.0 -359000.0 -1.76 1403410.0 -64600.0 -0.29 1315200.0 -159358.4375 -0.830626908231692 1368000.0 -247719.03225806 -1.19440469235295 -2.0341 -0.8849 2069443 Maybridge1_000201 O=C(N/N=C/c1cccs1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B04 compound treatment 978880.0 -672000.0 -3.29 1309280.0 -159000.0 -0.7 1233820.0 -240738.4375 -1.25480537566863 1205480.0 -410239.03225806 -1.97801283433448 -3.6137 -0.8814 2069444 Maybridge1_000202 COc1ccc(cc1)C(=O)NNC(=S)Nc2ccc(Cl)cc2C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B05 compound treatment 1290810.0 -361000.0 -1.76 1466250.0 -1770.0 -0.01 1554830.0 80271.5625 0.418400938314308 1411590.0 -204129.03225806 -0.984230689713427 -1.1689 -0.5666 2069445 Maybridge1_000203 COc1cc(cc(OC)c1OC)C2SCc3cc(C)c(C)cc3CS2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B06 compound treatment 1199620.0 -452000.0 -2.21 1386160.0 -81900.0 -0.36 1496230.0 21671.5625 0.112959082922264 1506110.0 -109609.03225806 -0.528492063205341 -1.4945 -0.6486 2069446 Maybridge1_000204 CC(=O)CS(=O)(=O)c1ccc(C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B07 compound treatment 1252530.0 -399000.0 -1.95 1432560.0 -35500.0 -0.16 1633030.0 158471.5625 0.826004233393794 1439440.0 -176279.03225806 -0.849948836684966 -1.0664 -0.4659 2069447 Maybridge1_000205 Cc1cccc(Cl)c1/N=C/2\SC(=C)C3(CCCCC3)N2C(=O)c4sc5ccccc5c4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B08 compound treatment 1188360.0 -463000.0 -2.27 1302310.0 -166000.0 -0.73 1559790.0 85231.5625 0.444254037337253 1472360.0 -143359.03225806 -0.691221418311646 -1.6237 -0.6445 2069448 Maybridge1_000206 CC(C)CC(C)(SCC(=O)O)SCC(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B09 compound treatment 1208240.0 -443000.0 -2.17 1376910.0 -91100.0 -0.4 1562960.0 88401.5625 0.460777086511191 1481050.0 -134669.03225806 -0.649321622878348 -1.3804 -0.5887 1559306 Maybridge1_000207 COc1ccc(NC(=S)Nc2c(C)cccc2C)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B10 compound treatment 1153120.0 -498000.0 -2.44 1258590.0 -209000.0 -0.93 1445460.0 -29098.4375 -0.151670319778318 1386890.0 -228829.03225806 -1.10332446959863 -2.3109 -0.8146 2069449 Maybridge1_000208 Cc1cccc2CCCN(C(=S)Nc3cccc(Cl)c3)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B11 compound treatment 1427680.0 -224000.0 -1.09 1313040.0 -155000.0 -0.69 1594880.0 120321.5625 0.627154288287881 1500020.0 -115699.03225806 -0.557855671282301 -0.8562 -0.5556 1049127 Maybridge1_000209 CC(=O)Nc1ccc(C)c(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B12 compound treatment 1395330.0 -256000.0 -1.25 1393760.0 -74300.0 -0.33 1518690.0 44131.5625 0.230027753094709 1462750.0 -152969.03225806 -0.737557095424878 -1.0448 -0.6927 2069450 Maybridge1_000210 Fc1ccc(NC(=O)c2ccccc2NC(=S)Nc3cccc(c3)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B13 compound treatment 1245600.0 -406000.0 -1.99 1444670.0 -23400.0 -0.1 1448520.0 -26038.4375 -0.135720625623034 1442180.0 -173539.03225806 -0.836737623855594 -1.5307 -0.7082 2069451 Maybridge1_000211 COc1ccc(NC(=O)/C=N/O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B14 compound treatment 1607680.0 -43700.0 -0.21 1265200.0 -203000.0 -0.9 1517600.0 43041.5625 0.224346326091683 1442480.0 -173239.03225806 -0.835291140699094 -0.862 -0.6809 1083091 Maybridge1_000212 CC(=O)c1cc2cc(Br)ccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B15 compound treatment 1589130.0 -62200.0 -0.3 1235430.0 -233000.0 -1.03 1345090.0 -129468.4375 -0.674830712708344 1624500.0 8780.96774193994 0.0423384064549674 -0.9842 -0.7747 2069452 Maybridge1_000213 [O-][N+](=O)c1ccc(SCC(=O)Nc2ccc(F)cc2)c(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B16 compound treatment 1513410.0 -138000.0 -0.67 1231000.0 -237000.0 -1.05 1465400.0 -9158.4375 -0.0477366918514006 1497240.0 -118479.03225806 -0.571259748532539 -1.1725 -0.8531 2069453 Maybridge1_000214 CN(C)c1ccc(/C=N/CCC\N=C\c2ccc(cc2)N(C)C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B17 compound treatment 1328040.0 -323000.0 -1.58 1171950.0 -296000.0 -1.31 1417510.0 -57048.4375 -0.29735461769995 1569130.0 -46589.0322580601 -0.224634168129806 -1.7085 -0.8177 1921422 Maybridge1_000215 COc1ccc(/C=N/Cc2ccccc2)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B18 compound treatment 1487470.0 -164000.0 -0.8 1348060.0 -120000.0 -0.53 1518410.0 43851.5625 0.228568303956317 1607680.0 -8039.03225806006 -0.0387610825194932 -0.572 -0.5779 1017542 Maybridge1_000216 Cc1cc(O)c2ccccc2n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B19 compound treatment 1455490.0 -196000.0 -0.96 1257380.0 -211000.0 -0.93 1489770.0 15211.5625 0.0792875063722192 1546660.0 -69059.0322580601 -0.332975756551692 -1.0731 -0.7768 2069454 Maybridge1_000217 COc1cc(/N=C/c2ccc3OCOc3c2)c(OC)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B20 compound treatment 1495210.0 -156000.0 -0.76 1234310.0 -234000.0 -1.04 1425400.0 -49158.4375 -0.256229425907404 1335200.0 -280519.03225806 -1.35255351746367 -1.7046 -0.9043 2069455 Maybridge1_000218 Cc1ccc(NS(=O)(=O)C)cc1/N=C/c2ccccc2O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B21 compound treatment 1565250.0 -86100.0 -0.42 1237440.0 -231000.0 -1.02 1374620.0 -99938.4375 -0.5209109517915 1565850.0 -49869.0322580601 -0.240449050640878 -1.1026 -0.885 1721646 Maybridge1_000219 Fc1ccc(cc1)N2C(SCC2=O)c3ccc4OCOc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B22 compound treatment 1533160.0 -118000.0 -0.58 1209280.0 -259000.0 -1.15 1467310.0 -7248.4375 -0.0377811638002265 1632060.0 16340.9677419399 0.0787897819987797 -0.8424 -0.6541 2069456 Maybridge1_000220 COCCCNC(=S)Nc1cccc(Cl)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B23 mock treatment 1530880.0 -120000.0 -0.59 1344280.0 -124000.0 -0.55 1503880.0 29321.5625 0.152833318310474 1686090.0 70370.9677419399 0.339301398484517 -0.323 -0.3641 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 B24 mock treatment 1617070.0 -34300.0 -0.17 1417510.0 -50500.0 -0.22 1541330.0 66771.5625 0.348034640570407 1645440.0 29720.9677419399 0.143302930778701 0.0498 0.1062 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C01 compound treatment 1434560.0 -217000.0 -1.06 1518400.0 50400.0 0.22 1504060.0 29501.5625 0.153771535613726 1446320.0 -169399.03225806 -0.816776156295888 -0.7502 -0.5492 2069457 Maybridge1_000221 OCCN1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C02 compound treatment 1117810.0 -534000.0 -2.61 1270250.0 -198000.0 -0.88 1304480.0 -170078.4375 -0.886502960958701 1218010.0 -397709.03225806 -1.91759805449797 -3.146 -0.9063 2069458 Maybridge1_000222 C1CC1Nc2ncnc3scc(c4ccccc4)c23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C03 compound treatment 1284590.0 -367000.0 -1.79 1398880.0 -69100.0 -0.31 1357440.0 -117118.4375 -0.610458581068553 1342500.0 -273219.03225806 -1.31735576065549 -2.0145 -0.8651 2069459 Maybridge1_000223 FC(F)(F)c1ccnc(n1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C04 compound treatment 1134640.0 -517000.0 -2.53 1220010.0 -248000.0 -1.1 1461640.0 -12918.4375 -0.0673350088526649 1508160.0 -107559.03225806 -0.518607761635921 -2.1071 -0.7508 2069460 Maybridge1_000224 FC(F)(F)c1ccnc(n1)N2CCC(CC2)NC(=S)NC3CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C05 compound treatment 994250.0 -657000.0 -3.22 1301720.0 -166000.0 -0.74 1365190.0 -109368.4375 -0.570063113845202 1264370.0 -351349.03225806 -1.69406819071343 -3.1085 -0.8285 2069461 Maybridge1_000225 CC(C)(C)OC(=O)NCCNc1ccc(cc1N)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C06 compound treatment 1317710.0 -334000.0 -1.63 1404030.0 -64000.0 -0.28 1492690.0 18131.5625 0.0945074759583074 1483880.0 -131839.03225806 -0.635676465102027 -1.2288 -0.6914 2069462 Maybridge1_000226 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)Nc2ccc(OC(F)(F)F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C07 compound treatment 1503920.0 -147000.0 -0.72 1503370.0 35300.0 0.16 1389240.0 -85318.4375 -0.44470685749403 1529220.0 -86499.0322580601 -0.417064644049587 -0.7132 -0.7449 2069463 Maybridge1_000227 Cc1nc(ccc1C(=O)Nc2ccccc2F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C08 compound treatment 1205190.0 -446000.0 -2.18 1322530.0 -145000.0 -0.65 1497280.0 22721.5625 0.118432017191234 1334640.0 -281079.03225806 -1.3552536193558 -2.0326 -0.7664 1241428 Maybridge1_000228 Clc1ccc(cc1Cl)C(=O)N2CCN(CC2)c3cccc4scc(c5ccccc5)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C09 compound treatment 1005050.0 -646000.0 -3.16 1358930.0 -109000.0 -0.48 1368550.0 -106008.4375 -0.552549724184498 1265130.0 -350589.03225806 -1.69040376671696 -2.9446 -0.8045 2069464 Maybridge1_000229 FC(F)(F)c1cnc(N2CCCN(CC2)C(=O)Nc3ccc(Cl)cc3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C10 compound treatment 1046880.0 -604000.0 -2.96 999840.0 -468000.0 -2.08 1166360.0 -308198.4375 -1.60642837165408 1107200.0 -508519.03225806 -2.45188071640404 -4.5462 -0.977 2069465 Maybridge1_000230 Cc1ccc(cc1)c2csc3ncnc(NCc4ccco4)c23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C11 compound treatment 1255130.0 -396000.0 -1.94 1260480.0 -208000.0 -0.92 1369770.0 -104788.4375 -0.54619069579579 1500490.0 -115229.03225806 -0.555589514337117 -1.9805 -0.8674 2069466 Maybridge1_000231 [O-][N+](=O)c1ccc(nc1)N2CCCN(CC2)C(=S)Nc3ccc(F)cc3Br 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C12 compound treatment 1252870.0 -398000.0 -1.95 1262470.0 -206000.0 -0.91 1529440.0 54881.5625 0.28606017537226 1546020.0 -69699.0322580601 -0.33606158728556 -1.4557 -0.6625 2069467 Maybridge1_000232 Fc1ccccc1c2nnn[nH]2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C13 compound treatment 1317000.0 -334000.0 -1.64 1057280.0 -411000.0 -1.82 1304120.0 -170438.4375 -0.888379395565205 1319590.0 -296129.03225806 -1.42781885770691 -2.8869 -0.9719 2069468 Maybridge1_000233 Cc1cc(c(C)cc1Cl)S(=O)(=O)NCCNc2nccc(n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C14 compound treatment 1222370.0 -429000.0 -2.1 1003420.0 -465000.0 -2.06 1325120.0 -149438.4375 -0.778920710185803 1420640.0 -195079.03225806 -0.940595114492329 -2.9395 -0.923 2069469 Maybridge1_000234 COc1ccc(NC(=S)NNC(=O)c2ccccc2[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C15 compound treatment 1347150.0 -304000.0 -1.49 1167400.0 -301000.0 -1.33 1390560.0 -83998.4375 -0.437826597270182 1500540.0 -115179.03225806 -0.555348433811033 -1.9074 -0.8999 2069470 Maybridge1_000235 c1csc(c1)c2ccn(n2)c3nc(ns3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C16 compound treatment 701860.0 -949000.0 -4.65 840350.0 -628000.0 -2.78 1007700.0 -466858.4375 -2.43341480128722 601960.0 -1013759.03225806 -4.88795121637172 -7.3756 -0.959 2069471 Maybridge1_000236 CCCCCc1ccc(NC(=O)NNc2ccc(F)c(Cl)c2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C17 compound treatment 1419570.0 -232000.0 -1.13 1267700.0 -200000.0 -0.89 1545540.0 70981.5625 0.369978500829801 1397850.0 -217869.03225806 -1.05047961828115 -1.3515 -0.7422 2069472 Maybridge1_000237 CCCCNC(=O)NCCNc1ccc(cn1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C18 compound treatment 1617760.0 -33600.0 -0.16 1243790.0 -224000.0 -0.99 1315850.0 -158708.4375 -0.827238901303282 1533380.0 -82339.0322580601 -0.397006744279447 -1.1915 -0.8742 2069473 Maybridge1_000238 Cc1cccc(C)c1NC(=S)NCc2ccco2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C19 compound treatment 1627390.0 -23900.0 -0.12 1524080.0 56100.0 0.25 1690960.0 216401.5625 1.1279538354904 1593970.0 -21749.0322580601 -0.104865362771565 0.5773 0.4952 1659799 Maybridge1_000239 CC(C)(C)OC(=O)N1CCCN(CC1)C(=S)Nc2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C20 compound treatment 1583220.0 -68100.0 -0.33 1273220.0 -195000.0 -0.86 1422580.0 -51978.4375 -0.270928163658352 1523910.0 -91809.0322580601 -0.442667395919645 -0.9554 -0.9001 2069474 Maybridge1_000240 NS(=O)(=O)c1ccc(/N=C/c2ccc3OCOc3c2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C21 compound treatment 1553440.0 -97900.0 -0.48 1248980.0 -219000.0 -0.97 1203080.0 -271478.4375 -1.41503204179067 1423770.0 -191949.03225806 -0.925503473559508 -1.8955 -0.944 1545894 Maybridge1_000241 CCOC(=O)c1c(sc(C)c1c2ccccc2)N3C(=O)CC4(CCCC4)C3=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C22 compound treatment 1430400.0 -221000.0 -1.08 1235130.0 -233000.0 -1.03 1438400.0 -36158.4375 -0.188469287339203 1525280.0 -90439.0322580601 -0.43606178950496 -1.3692 -0.8728 1922172 Maybridge1_000242 CCOc1ccc(/N=C/c2ccccc2O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C23 mock treatment 1698850.0 47500.0 0.23 1294160.0 -174000.0 -0.77 1448400.0 -26158.4375 -0.136346103825202 1599950.0 -15769.0322580601 -0.076032131851989 -0.3755 -0.4577 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 C24 mock treatment 1613850.0 -37500.0 -0.18 1238150.0 -230000.0 -1.02 1372510.0 -102048.4375 -0.531908943512954 1614650.0 -1069.03225806006 -0.0051544571834652 -0.87 -0.7471 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D01 compound treatment 1300500.0 -351000.0 -1.72 1533920.0 65900.0 0.29 1451600.0 -22958.4375 -0.119666685100722 1190240.0 -425479.03225806 -2.0514941786847 -1.7979 -0.6674 2069475 Maybridge1_000243 Clc1cccc(NC(=S)NNC(=O)c2cccnc2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D02 compound treatment 1465570.0 -186000.0 -0.91 1501530.0 33500.0 0.15 1449290.0 -25268.4375 -0.131707140492456 1305650.0 -310069.03225806 -1.49503210837897 -1.1936 -0.6778 2069476 Maybridge1_000244 COc1cc(/C=N/c2ccc(C)c(Cl)c2)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D03 compound treatment 1252850.0 -398000.0 -1.95 1379040.0 -89000.0 -0.39 1430120.0 -44438.4375 -0.231627283288795 1359470.0 -256249.03225806 -1.23553303010278 -1.9059 -0.8099 1915764 Maybridge1_000245 O=C(N/N=C/c1cccc2ccccc12)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D04 compound treatment 1115680.0 -536000.0 -2.62 1123460.0 -345000.0 -1.53 1280800.0 -193758.4375 -1.00993065951985 1101920.0 -513799.03225806 -2.47733881995845 -3.8183 -0.9439 2069477 Maybridge1_000246 CCOC(=O)CSC(=O)c1c(C)onc1c2c(Cl)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D05 compound treatment 1062810.0 -589000.0 -2.88 1185240.0 -283000.0 -1.25 1351730.0 -122828.4375 -0.640220918855047 1218880.0 -396839.03225806 -1.91340325334412 -3.3438 -0.8957 2069478 Maybridge1_000247 Cc1cc2CSC(SCc2cc1C)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D06 compound treatment 1260270.0 -391000.0 -1.91 1445770.0 -22300.0 -0.1 1402470.0 -72088.4375 -0.375747885705007 1397610.0 -218109.03225806 -1.05163680480635 -1.7199 -0.7755 2069479 Maybridge1_000248 COc1cc(/C=N/CCCC\N=C\c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D07 compound treatment 1466840.0 -184000.0 -0.9 1226000.0 -242000.0 -1.07 1385780.0 -88778.4375 -0.462741478989875 1428000.0 -187719.03225806 -0.905108061052851 -1.672 -0.9653 2069480 Maybridge1_000249 Clc1c(sc2ccccc12)C(=O)N3/C(=N/c4ccccc4Cl)/SC(=C)C53CCCCC5 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D08 compound treatment 1433030.0 -218000.0 -1.07 1309230.0 -159000.0 -0.7 1488040.0 13481.5625 0.0702701956242971 1324700.0 -291019.03225806 -1.40318042794118 -1.5527 -0.8171 1353182 Maybridge1_000250 Cc1ccc2N(CCCc2c1)C(=S)Nc3c(C)cccc3C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D09 compound treatment 1489630.0 -162000.0 -0.79 1165040.0 -303000.0 -1.34 1402820.0 -71738.4375 -0.373923574282017 1361400.0 -254319.03225806 -1.22622732179596 -1.8675 -0.9251 1404608 Maybridge1_000251 COc1ccc(NC(=S)Nc2ccccc2Cl)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D10 compound treatment 1188510.0 -463000.0 -2.26 1177600.0 -290000.0 -1.29 1396210.0 -78348.4375 -0.408376998584772 1306530.0 -309189.03225806 -1.4907890911199 -2.726 -0.8998 1705422 Maybridge1_000252 Clc1cccc(NC(=S)N2CCCc3ccccc23)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D11 compound treatment 1276960.0 -374000.0 -1.83 1257120.0 -211000.0 -0.94 1345150.0 -129408.4375 -0.67451797360726 1367840.0 -247879.03225806 -1.19517615003641 -2.3185 -0.9376 2069481 Maybridge1_000253 CC(=O)Nc1ccc(C)c(/N=C/c2ccc(Cl)c(Cl)c2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D12 compound treatment 1396160.0 -255000.0 -1.25 1399150.0 -68900.0 -0.31 1399280.0 -75278.4375 -0.392375181245974 1536710.0 -79009.0322580601 -0.380950781242291 -1.1637 -0.833 1653449 Maybridge1_000254 Fc1ccc(NC(=O)c2ccccc2NC(=S)Nc3ccccc3Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D13 compound treatment 1304800.0 -347000.0 -1.7 1136120.0 -332000.0 -1.47 1655110.0 180551.5625 0.941092222592708 1533410.0 -82309.0322580601 -0.396862095963797 -1.3117 -0.5317 2069482 Maybridge1_000255 OC(=O)CSC(SCC(=O)O)c1cccs1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D14 compound treatment 1374350.0 -277000.0 -1.36 1418660.0 -49400.0 -0.22 1526570.0 52011.5625 0.271100821703742 1457010.0 -158709.03225806 -0.765233139819254 -1.0342 -0.6484 1541673 Maybridge1_000256 CS(=O)(=O)N(Cc1ccccc1)Cc2ccc3OCOc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D15 compound treatment 1100880.0 -550000.0 -2.69 945920.0 -522000.0 -2.32 1174330.0 -300228.4375 -1.56488619439342 1136250.0 -479469.03225806 -2.31181293074957 -4.4428 -0.9834 2069483 Maybridge1_000257 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc(CC#N)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D16 compound treatment 1393120.0 -258000.0 -1.26 1456050.0 -12000.0 -0.05 1351730.0 -122828.4375 -0.640220918855047 1430140.0 -185579.03225806 -0.894789814536481 -1.4258 -0.8506 1040327 Maybridge1_000258 CC(=O)Nc1cc2ccccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D17 compound treatment 1473650.0 -178000.0 -0.87 1198420.0 -270000.0 -1.2 1319360.0 -155198.4375 -0.808943663889868 1446530.0 -169189.03225806 -0.815763618086337 -1.8449 -0.9854 2069484 Maybridge1_000259 Cc1ccc(cc1Cl)n2c(C)nc3cc(Cl)ccc3c2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D18 compound treatment 1723070.0 71700.0 0.35 1264080.0 -204000.0 -0.9 1376930.0 -97628.4375 -0.508870496399765 1604160.0 -11559.0322580601 -0.0557331515557655 -0.559 -0.5096 1578175 Maybridge1_000260 Cc1cc(O)c2cc(F)ccc2n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D19 compound treatment 1564830.0 -86500.0 -0.42 1316900.0 -151000.0 -0.67 1584870.0 110311.5625 0.574978981590366 1413970.0 -201749.03225806 -0.972755256671857 -0.7456 -0.5402 2069485 Maybridge1_000261 CC(=O)Nc1ccc(cc1[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D20 compound treatment 1552340.0 -99000.0 -0.48 1197060.0 -271000.0 -1.2 1322370.0 -152188.4375 -0.793254585652154 1226560.0 -389159.03225806 -1.87637328453771 -2.1779 -0.9021 2069486 Maybridge1_000262 Cc1ccc(NS(=O)(=O)C)cc1/N=C/c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D21 compound treatment 1496910.0 -154000.0 -0.76 1115040.0 -353000.0 -1.57 1081700.0 -392858.4375 -2.04770324328361 1326100.0 -289619.03225806 -1.39643017321085 -2.8826 -0.9522 2069487 Maybridge1_000263 COc1ccc(/N=C/c2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D22 compound treatment 1376600.0 -275000.0 -1.34 1122760.0 -345000.0 -1.53 1223920.0 -250638.4375 -1.30640732734749 1406530.0 -209189.03225806 -1.00862803895307 -2.5953 -0.9897 2069488 Maybridge1_000264 COCCCn1c(=O)c2ccccc2[nH]c1=S 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D23 mock treatment 1591780.0 -59600.0 -0.29 1243080.0 -225000.0 -1.0 1343750.0 -130808.4375 -0.68181521929922 1688160.0 72440.9677419399 0.34928213226437 -0.8108 -0.628 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 D24 mock treatment 1692250.0 40900.0 0.2 1461600.0 -6420.0 -0.03 1320550.0 -154008.4375 -0.802741005051702 1566740.0 -48979.0322580601 -0.236157817276593 -0.4336 -0.5037 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E01 compound treatment 1499200.0 -152000.0 -0.74 1619380.0 151000.0 0.67 1538080.0 63521.5625 0.331094605928357 1333600.0 -282119.03225806 -1.36026809429834 -0.5512 -0.3201 1245819 Maybridge1_000265 OCCN1CCN(Cc2ccc(F)cc2)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E02 compound treatment 1597150.0 -54200.0 -0.27 1608000.0 140000.0 0.62 1565660.0 91101.5625 0.474850346059971 1618660.0 2940.96774193994 0.0141802010084246 0.4223 0.5116 1738877 Maybridge1_000266 CN(C)CCNc1ncnc2scc(c3ccccc3)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E03 compound treatment 1156060.0 -495000.0 -2.42 1413940.0 -54100.0 -0.24 1519360.0 44801.5625 0.233520006390147 1296360.0 -319359.03225806 -1.53982487012526 -1.9849 -0.6866 2069489 Maybridge1_000267 CC(=O)Nc1cc(ccc1Sc2ccccc2N)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E04 compound treatment 1270880.0 -380000.0 -1.86 1395100.0 -72900.0 -0.32 1243160.0 -231398.4375 -1.20612232226655 1339110.0 -276609.03225806 -1.33370102032394 -2.3625 -0.9057 1611827 Maybridge1_000268 CC(C)(C)OC(=O)NC1CCN(Cc2c(F)cccc2Cl)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E05 compound treatment 1210290.0 -441000.0 -2.16 1230400.0 -238000.0 -1.05 1500020.0 25461.5625 0.13271376947407 1401050.0 -214669.03225806 -1.03505046461181 -2.0572 -0.7856 2069490 Maybridge1_000269 FC(F)(F)c1ccnc(n1)N2CCCNCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E06 compound treatment 1225810.0 -426000.0 -2.08 1117280.0 -351000.0 -1.56 1353120.0 -121438.4375 -0.632975796346601 1348230.0 -267489.03225806 -1.28972793236633 -2.7802 -0.9362 2069491 Maybridge1_000270 FC(F)(F)c1ccc(NC(=O)N2CCCN(CC2)c3ncc(cc3Cl)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E07 compound treatment 1524040.0 -127000.0 -0.62 1420030.0 -48000.0 -0.21 1442880.0 -31678.4375 -0.16511810112493 1435690.0 -180029.03225806 -0.868029876141222 -0.9344 -0.8481 2069492 Maybridge1_000271 CC(N1CCCCC1)C(=O)Nc2c(C)cccc2C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E08 compound treatment 1225860.0 -425000.0 -2.08 1425530.0 -42500.0 -0.19 1658120.0 183561.5625 0.956781300830422 1481460.0 -134259.03225806 -0.647344762564464 -0.9805 -0.4105 1434180 Maybridge1_000272 Cc1nc(cs1)c2ccc(s2)S(=O)(=O)N3CCN(CC3)c4ncnc5scc(c6ccccc6)c45 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E09 compound treatment 1169770.0 -482000.0 -2.36 1211520.0 -257000.0 -1.14 1251750.0 -222808.4375 -1.16134850762803 1130240.0 -485479.03225806 -2.3407908099848 -3.4981 -0.9459 2069493 Maybridge1_000273 OC(CNCCNc1nccc(n1)C(F)(F)F)Cn2ccc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E10 compound treatment 820640.0 -831000.0 -4.06 937280.0 -531000.0 -2.35 1014450.0 -460108.4375 -2.39823165241526 979200.0 -636519.03225806 -3.06904686317758 -5.943 -0.9739 2069494 Maybridge1_000274 Cc1onc(c1C(=O)N2CCN(CC2)c3ncnc4scc(c5ccccc5)c34)c6c(Cl)cccc6Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E11 compound treatment 1314760.0 -337000.0 -1.65 1310240.0 -158000.0 -0.7 1489400.0 14841.5625 0.0773589485822012 1565930.0 -49789.0322580601 -0.240063321799144 -1.2547 -0.6943 1286913 Maybridge1_000275 CC(=O)Nc1ccc(cc1Cl)S(=O)(=O)N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E12 compound treatment 1363800.0 -288000.0 -1.41 1412290.0 -55700.0 -0.25 1434150.0 -40408.4375 -0.210621640332653 1368360.0 -247359.03225806 -1.19266891256515 -1.5287 -0.8163 1722412 Maybridge1_000276 OC(COc1ccc(Cl)c(Cl)c1)CN2CCN(CC2)c3ncnc4scc(c5ccccc5)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E13 compound treatment 1479450.0 -172000.0 -0.84 1203710.0 -264000.0 -1.17 1364400.0 -110158.4375 -0.574180845342808 1583470.0 -32249.0322580601 -0.155492273249082 -1.3715 -0.8788 2069495 Maybridge1_000277 FC(F)(F)c1ccnc(NC2CCN(Cc3ccccc3)CC2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E14 compound treatment 1580380.0 -71000.0 -0.35 1592170.0 124000.0 0.55 1373640.0 -100918.4375 -0.526019023775872 1501000.0 -114719.03225806 -0.553130492971066 -0.4379 -0.4365 2069496 Maybridge1_000278 Nc1ccccc1Sc2ccc(cc2[N+](=O)[O-])c3cnc4ccccc4n3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E15 compound treatment 1171730.0 -480000.0 -2.35 1013560.0 -454000.0 -2.02 1241760.0 -232798.4375 -1.21341956795851 1145760.0 -469959.03225806 -2.26595941468851 -3.9209 -0.9748 2069497 Maybridge1_000279 OC(COc1ccc(cc1)[N+](=O)[O-])CN2CCCN(CC2)c3nc4ccc(Cl)cc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E16 compound treatment 1320120.0 -331000.0 -1.62 1223420.0 -245000.0 -1.08 1282330.0 -192228.4375 -1.00195581244221 1493190.0 -122529.03225806 -0.590787271145295 -2.1491 -0.9464 2069498 Maybridge1_000280 CC(Oc1ccc(Cl)cc1Cl)C(=O)NC2=NCCS2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E17 compound treatment 1648730.0 -2600.0 -0.01 1235920.0 -232000.0 -1.03 1452360.0 -22198.4375 -0.115705323153658 1629200.0 13480.9677419399 0.0649999759068084 -0.5464 -0.5264 2069499 Maybridge1_000281 FC(F)(F)c1ccnc(NCC=C)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E18 compound treatment 1708170.0 56800.0 0.28 1244590.0 -223000.0 -0.99 1404210.0 -70348.4375 -0.366678451773571 1609450.0 -6269.03225806006 -0.0302268318961403 -0.5548 -0.5076 2069500 Maybridge1_000282 CC(C)c1ccc(/C=C/2\CCC/C(=C\c3ccc(cc3)C(C)C)/C2=O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E19 compound treatment 1626040.0 -25300.0 -0.12 1191040.0 -277000.0 -1.23 1564070.0 89511.5625 0.466562759881245 1580560.0 -35159.0322580601 -0.169523159867137 -0.5275 -0.3965 2069501 Maybridge1_000283 FC(F)(F)c1cnc(NCCCNC(=S)Nc2cccnc2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E20 compound treatment 1585920.0 -65400.0 -0.32 1063310.0 -405000.0 -1.79 1323630.0 -150928.4375 -0.786687064529389 1305630.0 -310089.03225806 -1.4951285405894 -2.1984 -0.8844 2069502 Maybridge1_000284 Cc1cc(C)nc(NS(=O)(=O)c2ccc(/N=C/c3ccccc3O)cc2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E21 compound treatment 1639680.0 -11700.0 -0.06 1203960.0 -264000.0 -1.17 1419840.0 -54718.4375 -0.285209915941188 1433600.0 -182119.03225806 -0.878107042131508 -1.1957 -0.8012 1322088 Maybridge1_000285 Cc1nc(cs1)c2ccc(s2)S(=O)(=O)N3CCCN(CC3)c4nc5ccc(Cl)cc5s4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E22 compound treatment 1623740.0 -27600.0 -0.14 1396390.0 -71600.0 -0.32 1531240.0 56681.5625 0.29544234840478 1441650.0 -174069.03225806 -0.839293077432079 -0.4983 -0.5221 2069503 Maybridge1_000286 Cc1ccc(/N=C/c2ccccc2O)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E23 mock treatment 1657090.0 5760.0 0.03 1418010.0 -50000.0 -0.22 1565760.0 91201.5625 0.475371577895111 1668800.0 53080.9677419399 0.255935752564873 0.2688 0.4601 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 E24 mock treatment 1699880.0 48500.0 0.24 1473070.0 5050.0 0.02 1599450.0 124891.5625 0.65097458315378 1582360.0 -33359.0322580601 -0.160844260928134 0.375 0.5269 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F01 compound treatment 1234010.0 -417000.0 -2.04 1446740.0 -21300.0 -0.09 1461190.0 -13368.4375 -0.069680552110795 1304120.0 -311599.03225806 -1.50240917247712 -1.8543 -0.7306 2069504 Maybridge1_000287 Cc1cccc(C)c1NC(=S)NNC(=O)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F02 compound treatment 1241320.0 -410000.0 -2.01 1533610.0 65600.0 0.29 1601440.0 126881.5625 0.661347096673066 1343850.0 -271869.03225806 -1.31084658645124 -1.1825 -0.4724 2069505 Maybridge1_000288 Fc1ccc(/N=C/c2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F03 compound treatment 1226750.0 -425000.0 -2.08 1422880.0 -45100.0 -0.2 1375040.0 -99518.4375 -0.518721778083912 1296440.0 -319279.03225806 -1.53943914128353 -2.168 -0.8197 2069506 Maybridge1_000289 Clc1ccccc1/C=N/NC(=O)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F04 compound treatment 1003810.0 -648000.0 -3.17 1187360.0 -281000.0 -1.24 1113460.0 -361098.4375 -1.88216001244314 1187040.0 -428679.03225806 -2.06692333235404 -4.1812 -0.9492 2069507 Maybridge1_000290 COC(=O)c1cccc(/N=C/c2cc(Cl)cc(Cl)c2O)c1C(=O)OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F05 compound treatment 1229770.0 -422000.0 -2.06 1326900.0 -141000.0 -0.63 1452510.0 -22048.4375 -0.114923475400948 1440070.0 -175649.03225806 -0.846911222056315 -1.8253 -0.7871 2069508 Maybridge1_000291 Cc1cc2CSC(C)(SCc2cc1C)c3ccc(cc3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F06 compound treatment 1114400.0 -537000.0 -2.63 1353660.0 -114000.0 -0.51 1311930.0 -162628.4375 -0.84767118924077 1133980.0 -481739.03225806 -2.32275798663376 -3.1525 -0.8653 1461154 Maybridge1_000292 CC(N(Cc1ccccc1)C(=S)Nc2ccc(Cl)c(Cl)c2)c3ccccc3O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F07 compound treatment 1227760.0 -424000.0 -2.07 1138730.0 -329000.0 -1.46 1340850.0 -133708.4375 -0.69693094251828 1250020.0 -365699.03225806 -1.76325830169937 -2.9966 -0.9465 2069509 Maybridge1_000293 Cc1cccc(Cl)c1/N=C/2\NC3(CCCCC3)C(=C)S2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F08 compound treatment 1212180.0 -439000.0 -2.15 1395680.0 -72300.0 -0.32 1530630.0 56071.5625 0.292262834210426 1204510.0 -411209.03225806 -1.9826897965405 -2.0801 -0.7037 1680637 Maybridge1_000294 Cc1cccc(C)c1NC(=S)N2CCCc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F09 compound treatment 1296280.0 -355000.0 -1.74 1291740.0 -176000.0 -0.78 1514670.0 40111.5625 0.209074233322081 1429920.0 -185799.03225806 -0.895850568851248 -1.603 -0.7577 1024118 Maybridge1_000295 CC(=O)Nc1cc(ccc1C)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F10 compound treatment 1370570.0 -281000.0 -1.37 1280370.0 -188000.0 -0.83 1395210.0 -79348.4375 -0.413589316936172 1204190.0 -411529.03225806 -1.98423271190743 -2.302 -0.8901 1253012 Maybridge1_000296 Cc1ccc(NC(=S)N2CCCc3cccc(C)c23)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F11 compound treatment 1277230.0 -374000.0 -1.83 1330960.0 -137000.0 -0.61 1449920.0 -24638.4375 -0.128423379931074 1381840.0 -233879.03225806 -1.12767360273306 -1.8473 -0.8254 1011159 Maybridge1_000297 CC(=O)Nc1ccc(C)cc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F12 compound treatment 1405470.0 -246000.0 -1.2 1033040.0 -435000.0 -1.93 1133360.0 -341198.4375 -1.77843487725028 1377240.0 -238479.03225806 -1.14985301113273 -3.0302 -0.9753 1486966 Maybridge1_000298 Cc1ccc(NC(=S)Nc2ccccc2C(=O)Nc3ccc(F)cc3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F13 compound treatment 1387950.0 -263000.0 -1.29 1326580.0 -141000.0 -0.63 1420710.0 -53848.4375 -0.28067519897547 1530630.0 -85089.0322580601 -0.410266173214035 -1.3035 -0.8592 2069510 Maybridge1_000299 COc1cc(cc(OC)c1OC)C(SCC(=O)O)SCC(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F14 compound treatment 1474980.0 -176000.0 -0.86 1587630.0 120000.0 0.53 1390910.0 -83648.4375 -0.436002285847192 1518160.0 -97559.0322580601 -0.470391656419238 -0.6195 -0.5167 2069511 Maybridge1_000300 CC(C)N(Cc1ccc(cc1)N(C)C)C(=S)Nc2ccc(Cl)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F15 compound treatment 989400.0 -662000.0 -3.24 925700.0 -542000.0 -2.41 1130110.0 -344448.4375 -1.79537491189233 877800.0 -737919.03225806 -3.55795817007474 -5.4988 -0.9697 2069512 Maybridge1_000301 Oc1ccc(Br)cc1/C=N/c2ccc(CC#N)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F16 compound treatment 1601920.0 -49400.0 -0.24 1394880.0 -73100.0 -0.32 1529210.0 54651.5625 0.284861342151438 1216050.0 -399669.03225806 -1.92704841112044 -1.1042 -0.555 1177391 Maybridge1_000302 Oc1ccc(CCc2nnc(S)n2c3ccc(F)cc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F17 compound treatment 1514680.0 -137000.0 -0.67 1317200.0 -151000.0 -0.67 1470720.0 -3838.4375 -0.0200071582219522 1542730.0 -72989.0322580601 -0.351924685901848 -0.8548 -0.8468 2069513 Maybridge1_000303 Cc1nc2cc(Cl)ccc2c(=O)n1c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F18 compound treatment 1495200.0 -156000.0 -0.76 1255890.0 -212000.0 -0.94 1575120.0 100561.5625 0.524158877664216 1703770.0 88050.9677419399 0.424547472507612 -0.378 -0.2726 1393574 Maybridge1_000304 Cc1cc(O)c2c(Cl)ccc(C)c2n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F19 compound treatment 1342300.0 -309000.0 -1.51 1188340.0 -280000.0 -1.24 1367680.0 -106878.4375 -0.557084441150216 1378650.0 -237069.03225806 -1.14305454029718 -2.2263 -0.9543 1113094 Maybridge1_000305 COC(=O)c1ccccc1NC(=O)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F20 compound treatment 1498570.0 -153000.0 -0.75 1135860.0 -332000.0 -1.47 1324340.0 -150218.4375 -0.782986318499895 1419760.0 -195959.03225806 -0.944838131751397 -1.9742 -0.9594 2069514 Maybridge1_000306 Cc1ccc(NS(=O)(=O)C)cc1/N=C/c2ccc(Cl)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F21 compound treatment 1593150.0 -58200.0 -0.28 1225190.0 -243000.0 -1.08 1450920.0 -23638.4375 -0.123211061579674 1578140.0 -37579.0322580601 -0.181191457329574 -0.833 -0.7338 2069515 Maybridge1_000307 C(/N=C/c1ccc2OCOc2c1)c3ccco3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F22 compound treatment 1693280.0 41900.0 0.21 1247160.0 -221000.0 -0.98 1346560.0 -127998.4375 -0.667168604731786 1656920.0 41200.9677419399 0.198655019567453 -0.6214 -0.5097 2069516 Maybridge1_000308 COCCCNC(=S)Nc1ccc(C)cc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F23 mock treatment 1699040.0 47700.0 0.23 1310840.0 -157000.0 -0.7 1359580.0 -114978.4375 -0.599304219796557 1636720.0 21000.9677419399 0.101258487029754 -0.4808 -0.5041 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 F24 mock treatment 1644920.0 -6410.0 -0.03 1299200.0 -169000.0 -0.75 1358400.0 -116158.4375 -0.605454755451209 1690240.0 74520.9677419399 0.359311082149441 -0.5131 -0.499 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G01 compound treatment 1351040.0 -300000.0 -1.47 1388160.0 -79900.0 -0.35 1244540.0 -230018.4375 -1.19892932294162 1364240.0 -251479.03225806 -1.21253394791442 -2.1176 -0.9293 2069517 Maybridge1_000309 On1nnc2ccc(cc12)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G02 compound treatment 1412290.0 -239000.0 -1.17 1539750.0 71700.0 0.32 1482240.0 7681.5625 0.0400387491861766 1322080.0 -293639.03225806 -1.41581304750796 -1.1137 -0.5974 2069518 Maybridge1_000310 CCOC(=O)c1cc(C(=S)N)c(C)nc1C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G03 compound treatment 1288570.0 -363000.0 -1.78 1410910.0 -57100.0 -0.25 1301510.0 -173048.4375 -0.901983546462359 1254410.0 -361309.03225806 -1.74209143150925 -2.3363 -0.879 1521295 Maybridge1_000311 CCOC(=O)C1CCN(CC1)c2nc3ccc(Cl)cc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G04 compound treatment 1228800.0 -423000.0 -2.07 1377650.0 -90400.0 -0.4 1367570.0 -106988.4375 -0.55765779616887 1225810.0 -389909.03225806 -1.87998949242896 -2.453 -0.8524 2069519 Maybridge1_000312 CC(C)(C)OC(=O)NC1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G05 compound treatment 1177970.0 -473000.0 -2.32 1058570.0 -409000.0 -1.82 1095360.0 -379198.4375 -1.97650297460348 1268360.0 -347359.03225806 -1.67482996473198 -3.8918 -0.9925 2069520 Maybridge1_000313 Fc1cccc(Cl)c1CN2CCN(CC2)c3nccc(n3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G06 compound treatment 964050.0 -687000.0 -3.36 979320.0 -489000.0 -2.17 1179250.0 -295308.4375 -1.53924158810453 1108660.0 -507059.03225806 -2.4448411650424 -4.7573 -0.964 2069521 Maybridge1_000314 COc1ccccc1NC(=O)NC2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G07 compound treatment 1497970.0 -153000.0 -0.75 1179950.0 -288000.0 -1.28 1477760.0 3201.5625 0.0166875629719043 1297180.0 -318539.03225806 -1.5358711494975 -1.7736 -0.8311 1674114 Maybridge1_000315 CCc1ccccc1n2c(S)nc3ccccc3c2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G08 compound treatment 1169550.0 -482000.0 -2.36 1341990.0 -126000.0 -0.56 1438620.0 -35938.4375 -0.187322577301895 1317730.0 -297989.03225806 -1.43678705327721 -2.2703 -0.8042 2069522 Maybridge1_000316 CCCCCc1ccc(cc1)S(=O)(=O)N2CCN(CC2)C(=O)OC(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G09 compound treatment 1430240.0 -221000.0 -1.08 1336450.0 -132000.0 -0.58 1531200.0 56641.5625 0.295233855670724 1465380.0 -150339.03225806 -0.72487625975289 -1.0475 -0.7188 2069523 Maybridge1_000317 OC1CCCCC1NCCNc2nccc(n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G10 compound treatment 1328320.0 -323000.0 -1.58 1242590.0 -225000.0 -1.0 1390120.0 -84438.4375 -0.440120017344798 1347160.0 -268559.03225806 -1.29488705562452 -2.1577 -0.9313 2069524 Maybridge1_000318 FC(F)(F)c1ccnc(n1)N2CCCN(CC2)c3ncnc4scc(c5ccccc5)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G11 compound treatment 1142310.0 -509000.0 -2.49 1358920.0 -109000.0 -0.48 1332650.0 -141908.4375 -0.739671952999761 1347010.0 -268709.03225806 -1.29561029720277 -2.505 -0.851 2069525 Maybridge1_000319 CC(C)(C)c1ccc(NC(=O)N2CCCN(CC2)c3ccc(cn3)[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G12 compound treatment 1555930.0 -95400.0 -0.47 1378740.0 -89300.0 -0.4 1396210.0 -78348.4375 -0.408376998584772 1448800.0 -166919.03225806 -0.80481856220215 -1.038 -0.9518 2069526 Maybridge1_000320 CC(=O)Nc1ccc(cc1Cl)S(=O)(=O)NCCCN2CCN(Cc3ccccc3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G13 compound treatment 1458660.0 -193000.0 -0.94 1636410.0 168000.0 0.75 1615690.0 141131.5625 0.735622633180517 1511850.0 -103869.03225806 -0.500816018810965 0.0194 0.0129 1664341 Maybridge1_000321 S=C(NCC1CC1)Nc2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G14 compound treatment 1521760.0 -130000.0 -0.63 1615730.0 148000.0 0.66 1550890.0 76331.5625 0.397864404009792 1167770.0 -447949.03225806 -2.15983576710659 -0.8705 -0.3661 1019841 Maybridge1_000322 Cc1ccccc1C(=O)c2ccccc2C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G15 compound treatment 774490.0 -877000.0 -4.29 672580.0 -795000.0 -3.53 789640.0 -684918.4375 -3.57001294099352 738530.0 -877189.03225806 -4.22946386742748 -7.8089 -0.9959 2069527 Maybridge1_000323 FC(F)(F)c1ccnc(n1)n2ccc(n2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G16 compound treatment 210170.0 -1440000.0 -7.05 269860.0 -1200000.0 -5.31 295400.0 -1179158.4375 -6.14614916298949 263720.0 -1351999.03225806 -6.5188127592208 -12.5154 -0.9949 1780339 Maybridge1_000324 [O-][N+](=O)c1ccc(o1)C(=O)Nc2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G17 compound treatment 1607420.0 -43900.0 -0.21 1185840.0 -282000.0 -1.25 1333830.0 -140728.4375 -0.733521417345109 1448830.0 -166889.03225806 -0.8046739138865 -1.5023 -0.8981 2069528 Maybridge1_000325 FC(F)(F)c1ccnc(NCCN2C(=O)CC3(CCCC3)C2=O)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G18 compound treatment 1623700.0 -27600.0 -0.14 1234580.0 -233000.0 -1.04 1542190.0 67631.5625 0.352517234352611 1518100.0 -97619.0322580601 -0.470680953050538 -0.6443 -0.5377 2069529 Maybridge1_000326 CC/1CC(C)(C)C\C1=N/Nc2ccc(cc2[N+](=O)[O-])[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G19 compound treatment 1499140.0 -152000.0 -0.74 1547230.0 79200.0 0.35 1589680.0 115121.5625 0.600050232860601 1364760.0 -250959.03225806 -1.21002671044315 -0.5017 -0.3172 2069530 Maybridge1_000327 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc2ccc(nc2C)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G20 compound treatment 1662500.0 11200.0 0.05 1411230.0 -56800.0 -0.25 1516640.0 42081.5625 0.219342500474339 1510290.0 -105429.03225806 -0.508337731224768 -0.2431 -0.3981 2069531 Maybridge1_000328 C/C(=N\N=C(/C)\c1ccc(C)cc1)/c2ccc(C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G21 compound treatment 1574490.0 -76800.0 -0.38 1277520.0 -191000.0 -0.84 1421810.0 -52748.4375 -0.27494164878893 1558580.0 -57139.0322580601 -0.275502159133406 -0.8857 -0.8827 2069532 Maybridge1_000329 CC(C)(C)OC(=O)NCCNc1ccc(cc1N2C(=O)CC3(CCCC3)C2=O)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G22 compound treatment 1230270.0 -421000.0 -2.06 1090680.0 -377000.0 -1.67 1210880.0 -263678.4375 -1.37437595864975 1176640.0 -439079.03225806 -2.11706808177939 -3.6127 -0.9863 2069533 Maybridge1_000330 CC(=O)Nc1ccc(Br)cc1C(=O)C(=O)Nc2ccc3OCOc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G23 mock treatment 1653070.0 1740.0 0.01 1371450.0 -96600.0 -0.43 1469470.0 -5088.4375 -0.0265225561612023 1534880.0 -80839.0322580601 -0.389774328496944 -0.418 -0.7211 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 G24 mock treatment 1602320.0 -49000.0 -0.24 1528290.0 60300.0 0.27 1549040.0 74481.5625 0.388221615059702 1599890.0 -15829.0322580601 -0.0763214284832891 0.1697 0.3175 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H01 compound treatment 1315920.0 -335000.0 -1.64 1479810.0 11800.0 0.05 1270720.0 -203838.4375 -1.06247082850197 1267960.0 -347759.03225806 -1.67675860894064 -2.1641 -0.84 1944160 Maybridge1_000331 O=C(NNC(=S)Nc1ccccc1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H02 compound treatment 1184050.0 -467000.0 -2.29 1330670.0 -137000.0 -0.61 1250200.0 -224358.4375 -1.1694276010727 1241510.0 -374209.03225806 -1.80429020723877 -2.9347 -0.9179 2069534 Maybridge1_000332 Fc1ccc(cc1)N2C(SCC2=O)c3ccc(Cl)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H03 compound treatment 1359530.0 -292000.0 -1.43 1373700.0 -94300.0 -0.42 1245990.0 -228568.4375 -1.19137146133209 1225120.0 -390599.03225806 -1.88331640368891 -2.4605 -0.9182 2069535 Maybridge1_000333 CC(=O)N1N=C(OC1c2ccccc2Cl)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H04 compound treatment 1517600.0 -134000.0 -0.65 1555330.0 87300.0 0.39 1471360.0 -3198.4375 -0.0166712744770562 1437400.0 -178319.03225806 -0.859784922149169 -0.5718 -0.4982 2069536 Maybridge1_000334 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)SCC(=O)OCC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H05 compound treatment 1357360.0 -294000.0 -1.44 1435540.0 -32500.0 -0.14 1476690.0 2131.5625 0.0111103823359062 1441300.0 -174419.03225806 -0.840980641114663 -1.2062 -0.7212 2069537 Maybridge1_000335 Cc1cc2CSC(C)(SCc2cc1C)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H06 compound treatment 1227690.0 -424000.0 -2.07 1515360.0 47300.0 0.21 1572550.0 97991.5625 0.510763219501118 1352920.0 -262799.03225806 -1.26711457901971 -1.3097 -0.5257 2069538 Maybridge1_000336 NNS(=O)(=O)c1ccc(F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H07 compound treatment 1427230.0 -224000.0 -1.1 1295950.0 -172000.0 -0.76 1595870.0 121311.5625 0.632314483455767 1471410.0 -144309.03225806 -0.695801948307231 -0.9616 -0.5886 1917064 Maybridge1_000337 S=c1nc2[nH]c3ccccc3c2n[nH]1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H08 compound treatment 1282720.0 -369000.0 -1.8 1329790.0 -138000.0 -0.61 1459760.0 -14798.4375 -0.0771341673532971 1138480.0 -477239.03225806 -2.30106073928625 -2.3975 -0.8023 2069539 Maybridge1_000338 FC(F)(F)c1cccc(NC(=S)N2CCc3ccccc3C2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H09 compound treatment 1233130.0 -418000.0 -2.05 1187360.0 -281000.0 -1.24 1241970.0 -232588.4375 -1.21232498110472 1139290.0 -476429.03225806 -2.2971552347637 -3.4003 -0.9624 1048074 Maybridge1_000339 CN(C)c1ccc(cc1)C2Nc3cccc4cccc(N2)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H10 compound treatment 1267760.0 -384000.0 -1.88 1325890.0 -142000.0 -0.63 1323200.0 -151358.4375 -0.788928361420492 1427200.0 -188519.03225806 -0.908965349470185 -2.1026 -0.9074 1205163 Maybridge1_000340 Cc1ccc(NC(=S)N2CCCc3ccccc23)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H11 compound treatment 1313820.0 -338000.0 -1.65 1182770.0 -285000.0 -1.27 1346440.0 -128118.4375 -0.667794082933954 1467930.0 -147789.03225806 -0.712581152922636 -2.1485 -0.9349 2069540 Maybridge1_000341 COc1nc(Nc2cccc(c2)C(F)(F)F)nc(OC)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H12 compound treatment 1174750.0 -477000.0 -2.33 1220430.0 -248000.0 -1.1 1242350.0 -232208.4375 -1.21034430013119 1242720.0 -372999.03225806 -1.79845605850755 -3.2195 -0.9559 1127694 Maybridge1_000342 Fc1ccc(NC(=O)c2ccccc2NC(=S)Nc3ccc(Cl)c(Cl)c3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H13 compound treatment 1515120.0 -136000.0 -0.67 1300490.0 -168000.0 -0.74 1588120.0 113561.5625 0.591919016232417 1527480.0 -88239.0322580601 -0.42545424635729 -0.6215 -0.5029 2069541 Maybridge1_000343 OC(=O)CSC(SCC(=O)O)c1ccc2OCOc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H14 compound treatment 1516410.0 -135000.0 -0.66 1454900.0 -13100.0 -0.06 1523590.0 49031.5625 0.25556811301657 1442610.0 -173109.03225806 -0.834664331331277 -0.6488 -0.5919 2069542 Maybridge1_000344 CC(C)N(Cc1ccc(cc1)N(C)C)C(=S)Nc2ccc(C)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H15 compound treatment 1591870.0 -59500.0 -0.29 1313790.0 -154000.0 -0.68 1463200.0 -11358.4375 -0.0592037922244808 1372960.0 -242759.03225806 -1.17048950416547 -1.1023 -0.7943 1367412 Maybridge1_000345 CCOC(=O)c1ccc(cc1)N2C(=O)CC(SCC(=O)Nc3ccc(F)cc3)C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H16 compound treatment 1349570.0 -302000.0 -1.48 1361390.0 -107000.0 -0.47 1538480.0 63921.5625 0.333179533268917 1421050.0 -194669.03225806 -0.938618254178445 -1.2775 -0.6932 1578868 Maybridge1_000346 Cc1c(Cl)cccc1n2c(S)nnc2CCc3ccc(O)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H17 compound treatment 1503450.0 -148000.0 -0.72 1277730.0 -190000.0 -0.84 1464800.0 -9758.4375 -0.0508640828622407 1406770.0 -208949.03225806 -1.00747085242787 -1.313 -0.8746 1141423 Maybridge1_000347 Cc1nc2cc(Cl)ccc2c(=O)n1c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H18 compound treatment 1364520.0 -287000.0 -1.4 952580.0 -515000.0 -2.29 1233240.0 -241318.4375 -1.25782852031244 1321240.0 -294479.03225806 -1.41986320034616 -3.1835 -0.969 1562593 Maybridge1_000348 Cc1cc(O)c2cc(Cl)ccc2n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H19 compound treatment 1494400.0 -157000.0 -0.77 1162950.0 -305000.0 -1.35 1464710.0 -9848.4375 -0.0513331915138667 1319720.0 -295999.03225806 -1.42719204833909 -1.7997 -0.8522 1160657 Maybridge1_000349 COC(=O)c1ccccc1NC(=O)c2cc(OC)c(OC)c(OC)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H20 compound treatment 1106420.0 -545000.0 -2.67 1013840.0 -454000.0 -2.01 1100100.0 -374458.4375 -1.95179658561785 1059790.0 -555929.03225806 -2.68047327123633 -4.6565 -0.9891 2069543 Maybridge1_000350 Cc1ccc(NS(=O)(=O)C)cc1/N=C/c2cc(Cl)cc(Cl)c2O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H21 compound treatment 1024440.0 -627000.0 -3.07 1000960.0 -467000.0 -2.07 906620.0 -567938.4375 -2.96027594024674 1187260.0 -428459.03225806 -2.06586257803927 -5.0826 -0.983 1285265 Maybridge1_000351 CCOC(=O)C1CCN(CC1)c2nc(OC)nc(OC)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H22 compound treatment 1642490.0 -8840.0 -0.04 1191050.0 -277000.0 -1.23 1357030.0 -117528.4375 -0.612595631592627 1514180.0 -101539.03225806 -0.489581666295478 -1.1869 -0.8141 2069544 Maybridge1_000352 CN(C)c1ccc(/C=N/c2ccc(cc2)N3N=C(C)CC3=O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H23 mock treatment 1719300.0 68000.0 0.33 1272840.0 -195000.0 -0.87 1296370.0 -178188.4375 -0.928774862788555 1654560.0 38840.9677419399 0.187276018736316 -0.6373 -0.4807 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 H24 mock treatment 1667540.0 16200.0 0.08 1633860.0 166000.0 0.74 1597870.0 123311.5625 0.642739120158567 1677650.0 61930.9677419399 0.298607005681637 0.878 0.8571 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I01 compound treatment 1205660.0 -446000.0 -2.18 1388370.0 -79700.0 -0.35 1394400.0 -80158.4375 -0.417811294800806 1307480.0 -308239.03225806 -1.48620856112431 -2.2191 -0.8233 1454622 Maybridge1_000353 OCCN1CCN(CC1)c2nc3ccc(Cl)cc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I02 compound treatment 1277800.0 -374000.0 -1.83 1484110.0 16100.0 0.07 1399710.0 -74848.4375 -0.390133884354872 1295040.0 -320679.03225806 -1.54618939601387 -1.8464 -0.7609 2069545 Maybridge1_000354 NC1CCN(CC1)c2nccc(n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I03 compound treatment 851810.0 -800000.0 -3.91 1006080.0 -462000.0 -2.05 892530.0 -582028.4375 -3.03371750581796 854210.0 -761509.03225806 -3.6716999622809 -6.3332 -0.9751 1575257 Maybridge1_000355 Clc1ccc2nc(sc2c1)N3CCCNCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I04 compound treatment 1257700.0 -394000.0 -1.93 1380160.0 -87900.0 -0.39 1369440.0 -105118.4375 -0.547910760851752 1209600.0 -406119.03225806 -1.9581477989852 -2.411 -0.8526 1654743 Maybridge1_000356 CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I05 compound treatment 1088250.0 -563000.0 -2.76 1254450.0 -214000.0 -0.95 1289790.0 -184768.4375 -0.963071917540768 1131200.0 -484519.03225806 -2.336162063884 -3.5009 -0.9077 1266004 Maybridge1_000357 CCOC(=O)c1c(N)scc1C(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I06 compound treatment 759010.0 -892000.0 -4.37 610560.0 -857000.0 -3.8 544130.0 -930428.4375 -4.84968921944575 880710.0 -735009.03225806 -3.54392728345669 -8.2814 -0.9926 2069546 Maybridge1_000358 FC(F)(F)c1ccc(NC(=O)NC2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I07 compound treatment 1331750.0 -320000.0 -1.56 1537670.0 69600.0 0.31 1541140.0 66581.5625 0.347044300083641 1143610.0 -472109.03225806 -2.27632587731009 -1.5921 -0.5685 2069547 Maybridge1_000359 Cc1nc(ccc1C#N)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I08 compound treatment 1412520.0 -239000.0 -1.17 1553600.0 85600.0 0.38 1620770.0 146211.5625 0.762101210405629 1209560.0 -406159.03225806 -1.95834066340607 -0.9927 -0.4078 2069548 Maybridge1_000360 Cc1nc(nc(N2CCCN(CC2)c3ncc(cc3Cl)C(F)(F)F)c1Cl)c4cccnc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I09 compound treatment 1313250.0 -338000.0 -1.65 1371390.0 -96600.0 -0.43 1500030.0 25471.5625 0.132765892657584 1310720.0 -304999.03225806 -1.47058654303411 -1.7104 -0.7573 2069549 Maybridge1_000361 CC(C)(C)OC(=O)N/N=C\c1cccc2ccccc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I10 compound treatment 1154160.0 -497000.0 -2.43 1260800.0 -207000.0 -0.92 1280710.0 -193848.4375 -1.01039976817148 1201870.0 -413849.03225806 -1.9954188483177 -3.1788 -0.9267 2069550 Maybridge1_000362 Cc1c(sc2ncnc(O)c12)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I11 compound treatment 1133840.0 -517000.0 -2.53 1475520.0 7500.0 0.03 1426180.0 -48378.4375 -0.252163817593312 1187120.0 -428599.03225806 -2.06653760351231 -2.4089 -0.7348 1256094 Maybridge1_000363 OC(CNC1CCN(Cc2ccccc2)CC1)COc3ccc4OCOc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I12 compound treatment 1503010.0 -148000.0 -0.73 1257760.0 -210000.0 -0.93 1448800.0 -25758.4375 -0.134261176484642 1435390.0 -180329.03225806 -0.869476359297722 -1.331 -0.9035 2069551 Maybridge1_000364 FC(F)(F)c1ccnc(n1)N2CCN(CCCNC(=O)c3cccs3)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I13 compound treatment 1503320.0 -148000.0 -0.72 1271060.0 -197000.0 -0.87 1558170.0 83611.5625 0.435810081607984 1436320.0 -179399.03225806 -0.864992261512571 -1.0135 -0.6793 1454379 Maybridge1_000365 S=C(NCc1ccco1)Nc2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I14 compound treatment 1337130.0 -314000.0 -1.54 1156420.0 -312000.0 -1.38 1292890.0 -181668.4375 -0.946913730651428 1388800.0 -226919.03225806 -1.09411519350225 -2.4802 -0.9829 1651773 Maybridge1_000366 COC(=O)c1ccc(CSc2ccccc2NC(=S)Nc3cccc(SC)c3)o1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I15 compound treatment 1579700.0 -71600.0 -0.35 1195380.0 -273000.0 -1.21 1498840.0 24281.5625 0.126563233819418 1391000.0 -224719.03225806 -1.08350765035458 -1.2583 -0.7554 2069552 Maybridge1_000367 [O-][N+](=O)c1cc(ccc1n2ccc(n2)c3cccs3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I16 compound treatment 144220.0 -1510000.0 -7.37 100960.0 -1370000.0 -6.06 153570.0 -1320988.4375 -6.88541227476856 170250.0 -1445469.03225806 -6.96948869468114 -13.6462 -0.9976 2069553 Maybridge1_000368 CCOC(=O)c1ccc(NC(=O)c2ccc(o2)[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I17 compound treatment 1564120.0 -87200.0 -0.43 1287290.0 -181000.0 -0.8 1379210.0 -95348.4375 -0.496986410558573 1315480.0 -300239.03225806 -1.44763567695097 -1.5865 -0.8914 2069554 Maybridge1_000369 FC(F)(F)c1cccnc1NCCN2C(=O)CC3(CCCC3)C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I18 compound treatment 1338210.0 -313000.0 -1.53 1140560.0 -327000.0 -1.45 1271390.0 -203168.4375 -1.05897857520653 1344250.0 -271469.03225806 -1.30891794224257 -2.6762 -0.9911 1352465 Maybridge1_000370 CC(C)c1ccc(NC2(CCCCC2)C(=O)N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I19 compound treatment 1480920.0 -170000.0 -0.83 1250440.0 -218000.0 -0.96 1234880.0 -239678.4375 -1.24928031821615 1472160.0 -143559.03225806 -0.692185740415979 -1.8702 -0.9767 2069555 Maybridge1_000371 COc1ccc(OCC(O)CNCCNc2ncccc2C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I20 compound treatment 1443240.0 -208000.0 -1.02 1142640.0 -325000.0 -1.44 1390370.0 -84188.4375 -0.438816937756948 1497680.0 -118039.03225806 -0.569138239903005 -1.7346 -0.9097 2069556 Maybridge1_000372 C/C(=N\N=C(/C)\c1ccc(C)cc1C)/c2ccc(C)cc2C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I21 compound treatment 1400990.0 -250000.0 -1.23 1147380.0 -321000.0 -1.42 1269280.0 -205278.4375 -1.06997656692798 1443230.0 -172489.03225806 -0.831674932807843 -2.2743 -0.9824 1262020 Maybridge1_000373 OC(CN1CCC(CC1)NC2CCCCC2O)Cn3ccc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I22 compound treatment 1615680.0 -35700.0 -0.17 1231900.0 -236000.0 -1.05 1594580.0 120021.5625 0.625590592782461 1449040.0 -166679.03225806 -0.80366137567695 -0.6998 -0.4757 2069557 Maybridge1_000374 COc1ccc(cc1)/C(=N/N=C/c2cc(OC)c(OC)c(OC)c2)/C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I23 mock treatment 1695170.0 43800.0 0.21 1699520.0 231000.0 1.03 1378650.0 -95908.4375 -0.499905308835357 1593330.0 -22389.0322580601 -0.107951193505433 0.3166 0.2714 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 I24 mock treatment 1321170.0 -330000.0 -1.62 1483580.0 15600.0 0.07 1561210.0 86651.5625 0.451655529396241 1488280.0 -127439.03225806 -0.614461378806687 -0.8547 -0.4781 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J01 compound treatment 1192850.0 -458000.0 -2.24 1442990.0 -25000.0 -0.11 1453820.0 -20738.4375 -0.108095338360614 1049400.0 -566319.03225806 -2.73056980455646 -2.5966 -0.734 2069558 Maybridge1_000375 COc1cc(cc(OC)c1OC)C(=O)NNC(=O)c2sc3ccccc3c2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J02 compound treatment 1487160.0 -164000.0 -0.8 1342720.0 -125000.0 -0.56 1506090.0 31531.5625 0.164352541867068 1302080.0 -313639.03225806 -1.51224525794132 -1.3535 -0.7487 2069559 Maybridge1_000376 COc1cc(NS(=O)(=O)c2cc(ccc2C)[N+](=O)[O-])c(OC)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J03 compound treatment 1093980.0 -557000.0 -2.73 1463950.0 -4070.0 -0.02 1526260.0 51701.5625 0.269485003014808 1255910.0 -359809.03225806 -1.73485901572675 -2.1054 -0.6491 2069560 Maybridge1_000377 COc1ccc(/C=N/NC(=O)c2ccncc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J04 compound treatment 1225970.0 -425000.0 -2.08 1368280.0 -99700.0 -0.44 1475110.0 551.5625 0.0028749193406941 1216770.0 -398949.03225806 -1.92357685154484 -2.2223 -0.7747 2069561 Maybridge1_000378 COc1ccc(cc1)c2nnc(S)n2c3cccc(OC)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J05 compound treatment 705760.0 -946000.0 -4.63 963840.0 -504000.0 -2.24 1086250.0 -388308.4375 -2.02398719478474 780160.0 -835559.03225806 -4.02874022141043 -6.4579 -0.9446 2069562 Maybridge1_000379 COc1cc(ccc1O)C2(C)SCc3cc(C)c(C)cc3CS2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J06 compound treatment 1235910.0 -415000.0 -2.03 1462420.0 -5600.0 -0.02 1576240.0 101681.5625 0.529996674217784 1185320.0 -430399.03225806 -2.07521650245131 -1.8015 -0.61 2069563 Maybridge1_000380 CC(SCC(=O)O)(SCC(=O)O)c1cccc(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J07 compound treatment 1393470.0 -258000.0 -1.26 1392070.0 -76000.0 -0.34 1481500.0 6941.5625 0.0361816336061406 1156070.0 -459649.03225806 -2.21624861021011 -1.8894 -0.7344 1140994 Maybridge1_000381 Cc1onc(c1C(=O)N2CCc3ccccc3C2)c4ccccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J08 compound treatment 1126400.0 -525000.0 -2.57 1188700.0 -279000.0 -1.24 1260130.0 -214428.4375 -1.11766927984329 969700.0 -646019.03225806 -3.11485216313343 -4.02 -0.9202 2069564 Maybridge1_000382 Cc1cccc2CCCN(C(=S)Nc3cccc(c3)C(F)(F)F)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J09 compound treatment 1352570.0 -299000.0 -1.46 1138600.0 -329000.0 -1.46 1443060.0 -31498.4375 -0.164179883821678 1238560.0 -377159.03225806 -1.81851395827769 -2.4528 -0.8894 1048961 Maybridge1_000383 COc1cc(cc(OC)c1OC)C2Nc3cccc4cccc(N2)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J10 compound treatment 1274740.0 -377000.0 -1.84 1389610.0 -78400.0 -0.35 1403730.0 -70828.4375 -0.369180364582243 1311840.0 -303879.03225806 -1.46518633924984 -2.0125 -0.8356 2069565 Maybridge1_000384 Oc1ccc(CCC(=O)N/N=C/c2ccc(Cl)c(Cl)c2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J11 compound treatment 1156490.0 -495000.0 -2.42 1233850.0 -234000.0 -1.04 1378080.0 -96478.4375 -0.502876330295655 1210770.0 -404949.03225806 -1.95250651467485 -2.9577 -0.8915 2069566 Maybridge1_000385 Cc1ccc(Nc2nc3ccccc3s2)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J12 compound treatment 1556900.0 -94400.0 -0.46 1224000.0 -244000.0 -1.08 1390110.0 -84448.4375 -0.440172140528312 1486990.0 -128729.03225806 -0.620681256379639 -1.3026 -0.9295 2069567 Maybridge1_000386 Oc1ccc(CCC(=O)NNC(=S)Nc2cccc(c2)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J13 compound treatment 1485920.0 -165000.0 -0.81 1157790.0 -310000.0 -1.38 1522880.0 48321.5625 0.251867366987076 1455750.0 -159969.03225806 -0.771308369076556 -1.3523 -0.7552 1383075 Maybridge1_000387 CC1CC(=O)Nc2ccccc2N1C(=O)c3c(C)onc3c4ccccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J14 compound treatment 1509010.0 -142000.0 -0.7 1493870.0 25800.0 0.11 1478750.0 4191.5625 0.0218477581397904 1519200.0 -96519.0322580601 -0.465377181476703 -0.5127 -0.6062 2069568 Maybridge1_000388 CC(C)N(Cc1ccc(cc1)N(C)C)C(=S)Nc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J15 compound treatment 1623290.0 -28000.0 -0.14 1478920.0 10900.0 0.05 1503330.0 28771.5625 0.149966543217204 1518620.0 -97099.0322580601 -0.468173715579271 -0.2036 -0.397 1030886 Maybridge1_000389 CC(=O)Nc1cc(Cl)ccc1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J16 compound treatment 1503900.0 -147000.0 -0.72 1245920.0 -222000.0 -0.98 1531470.0 56911.5625 0.296641181625602 1471800.0 -143919.03225806 -0.69392152020378 -1.0519 -0.7328 1516286 Maybridge1_000390 Cc1ccc(c(C)c1)n2c(S)nnc2CCc3ccc(O)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J17 compound treatment 1451970.0 -199000.0 -0.98 1216970.0 -251000.0 -1.11 1313120.0 -161438.4375 -0.841468530402604 1226690.0 -389029.03225806 -1.87574647516989 -2.4031 -0.9486 2069569 Maybridge1_000391 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccccc2C(=O)Nc3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J18 compound treatment 1565880.0 -85500.0 -0.42 1241530.0 -226000.0 -1.0 1383200.0 -91358.4375 -0.476189260336487 1423080.0 -192639.03225806 -0.928830384819459 -1.4138 -0.9377 2069570 Maybridge1_000392 Cc1ccc(NS(=O)(=O)C)cc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J19 compound treatment 1342530.0 -309000.0 -1.51 1319620.0 -148000.0 -0.66 1453690.0 -20868.4375 -0.108772939746296 1587150.0 -28569.0322580601 -0.137748746529343 -1.2079 -0.7287 1040131 Maybridge1_000393 CC1CC(=O)Nc2cc(C)c(C)cc2N1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J20 compound treatment 1204060.0 -447000.0 -2.19 1022360.0 -446000.0 -1.98 1204760.0 -269798.4375 -1.40627534696032 1202950.0 -412769.03225806 -1.9902115089543 -3.7808 -0.9883 2069571 Maybridge1_000394 Cc1ccc(NS(=O)(=O)C)cc1/N=C/c2cc(Br)ccc2O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J21 compound treatment 1214560.0 -437000.0 -2.14 1202850.0 -265000.0 -1.18 1212450.0 -262108.4375 -1.36619261883805 1189540.0 -426179.03225806 -2.05486930604987 -3.3672 -0.9704 1635307 Maybridge1_000395 Clc1c(sc2ccccc12)C(=O)N3CCCc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J22 compound treatment 1569710.0 -81600.0 -0.4 1197640.0 -270000.0 -1.2 1399280.0 -75278.4375 -0.392375181245974 1448760.0 -166959.03225806 -0.805011426623017 -1.3979 -0.9025 2069572 Maybridge1_000396 CC(C)CCCC(C)C1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OC(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J23 mock treatment 1639640.0 -11700.0 -0.06 1570660.0 103000.0 0.46 1530080.0 55521.5625 0.289396059117156 1607520.0 -8199.03225806006 -0.0395325402029601 0.3239 0.5956 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 J24 mock treatment 1692180.0 40800.0 0.2 1543760.0 75700.0 0.34 1558970.0 84411.5625 0.439979936289104 1542560.0 -73159.0322580601 -0.352744359690532 0.3115 0.454 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K01 compound treatment 1376730.0 -275000.0 -1.34 1472890.0 4870.0 0.02 1538430.0 63871.5625 0.332918917351347 1457240.0 -158479.03225806 -0.76412416939927 -0.8767 -0.5544 2069573 Maybridge1_000397 OCCN1CCN(CC1)c2ncccc2[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K02 compound treatment 1343460.0 -308000.0 -1.51 1483720.0 15700.0 0.07 1560480.0 85921.5625 0.447850536999719 1192980.0 -422739.03225806 -2.03828296585533 -1.5137 -0.5879 1587186 Maybridge1_000398 OC(CNCc1ccc2OCOc2c1)COc3ccc(Cl)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K03 compound treatment 1368970.0 -282000.0 -1.38 1546140.0 78100.0 0.35 1579060.0 104501.5625 0.544695411968732 1263920.0 -351799.03225806 -1.69623791544818 -1.0934 -0.4794 1185686 Maybridge1_000399 OCCN1CCN(Cc2ccccc2F)CC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K04 compound treatment 1301060.0 -350000.0 -1.71 1452130.0 -15900.0 -0.07 1553850.0 79291.5625 0.413292866329936 1149600.0 -466119.03225806 -2.2474444302853 -1.8093 -0.6332 1632887 Maybridge1_000400 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K05 compound treatment 1280740.0 -371000.0 -1.81 1496750.0 28700.0 0.13 1545540.0 70981.5625 0.369978500829801 1201340.0 -414379.03225806 -1.99797430189418 -1.657 -0.6078 2069574 Maybridge1_000401 OC1CCN(CC1)c2nccc(n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K06 compound treatment 1511240.0 -140000.0 -0.69 1333390.0 -135000.0 -0.6 1557790.0 83231.5625 0.433829400634452 1445770.0 -169949.03225806 -0.819428042082805 -0.8341 -0.6424 2069575 Maybridge1_000402 CCc1cccc(C)c1NC(=O)NC2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K07 compound treatment 1604640.0 -46700.0 -0.23 1348430.0 -120000.0 -0.53 1491200.0 16641.5625 0.0867411216147213 1272170.0 -343549.03225806 -1.65645962864442 -1.1643 -0.6629 2069576 Maybridge1_000403 Cc1nc(ccc1C(=O)NN)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K08 compound treatment 1313710.0 -338000.0 -1.65 1340510.0 -128000.0 -0.57 1452000.0 -22558.4375 -0.117581757760162 1288050.0 -327669.03225806 -1.57989245356033 -1.9576 -0.8302 1289970 Maybridge1_000404 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCCN(CC2)c3ncnc4scc(c5ccccc5)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K09 compound treatment 1363890.0 -287000.0 -1.41 1330270.0 -138000.0 -0.61 1541170.0 66611.5625 0.347200669634183 1304800.0 -310919.03225806 -1.49913047732238 -1.5847 -0.7295 2069577 Maybridge1_000405 CCOC(=O)c1cc(c2nc(cs2)C(=O)NN)c(C)nc1C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K10 compound treatment 1377030.0 -274000.0 -1.34 1431580.0 -36400.0 -0.16 1505570.0 31011.5625 0.16164213632434 1376430.0 -239289.03225806 -1.15375851565528 -1.248 -0.6993 2069578 Maybridge1_000406 Cc1ccc(cc1)S(=O)(=O)NC(=O)NCCNc2ncc(cc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K11 compound treatment 1416730.0 -235000.0 -1.15 1428410.0 -39600.0 -0.18 1540440.0 65881.5625 0.343395677237661 1357600.0 -258119.03225806 -1.2445494417783 -1.1124 -0.6406 2069579 Maybridge1_000407 FC(F)(F)c1ccnc(NCCNC(=O)c2cccs2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K12 compound treatment 1526080.0 -125000.0 -0.61 1352560.0 -115000.0 -0.51 1371840.0 -102718.4375 -0.535401196808392 1516610.0 -99109.0322580601 -0.477865152727824 -1.0691 -0.9957 1651621 Maybridge1_000408 CCCc1cnc(nc1)N2CCCN(CC2)C(=O)OC(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K13 compound treatment 1483530.0 -168000.0 -0.82 1299520.0 -169000.0 -0.75 1584060.0 109501.5625 0.570757003725732 1345020.0 -270699.03225806 -1.30520530214089 -1.1514 -0.6375 2069580 Maybridge1_000409 FC(F)(F)c1ccnc(NCCNC(=S)Nc2cccnc2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K14 compound treatment 1543890.0 -107000.0 -0.53 1343580.0 -124000.0 -0.55 1524000.0 49441.5625 0.257705163540644 1511000.0 -104719.03225806 -0.504914387754383 -0.6624 -0.6973 2069581 Maybridge1_000410 CC(=O)c1cc(Cl)cc(Cl)c1OC(=O)c2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K15 compound treatment 1602950.0 -48400.0 -0.24 1306980.0 -161000.0 -0.71 1513350.0 38791.5625 0.202193973098233 1394650.0 -221069.03225806 -1.06590877195049 -0.9073 -0.6872 1570851 Maybridge1_000411 CCCc1cnc(nc1)N2CCCNCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K16 compound treatment 1647530.0 -3800.0 -0.02 1120650.0 -347000.0 -1.54 1282080.0 -192478.4375 -1.00325889203006 1451230.0 -164489.03225806 -0.793102048634497 -1.6777 -0.8379 2069582 Maybridge1_000412 FC(F)(F)c1cccc(NC(=S)NCc2ccco2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K17 compound treatment 1630750.0 -20600.0 -0.1 1526840.0 58800.0 0.26 1455380.0 -19178.4375 -0.0999641217324294 1365620.0 -250099.03225806 -1.20588012539452 -0.5729 -0.4613 2069583 Maybridge1_000413 Cc1nc(ccc1NC(=O)NCCNc2nccc(n2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K18 compound treatment 1666940.0 15600.0 0.08 1395330.0 -72700.0 -0.32 1556810.0 82251.5625 0.42872132865008 1583550.0 -32169.0322580601 -0.155106544407349 0.0138 0.0245 2069584 Maybridge1_000414 NC(=O)C1(CCCCC1)NC2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K19 compound treatment 1677360.0 26000.0 0.13 1207840.0 -260000.0 -1.15 1485730.0 11171.5625 0.0582297402325629 1481990.0 -133729.03225806 -0.64478930898798 -0.8065 -0.6068 1388914 Maybridge1_000415 CCCc1cnc(nc1)N2CCCN(CC2)C(=S)Nc3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K20 compound treatment 1667680.0 16300.0 0.08 1423720.0 -44300.0 -0.2 1367290.0 -107268.4375 -0.559117245307262 1351850.0 -263869.03225806 -1.27227370227789 -0.9739 -0.6928 1913698 Maybridge1_000416 COc1ccc(cc1)/C(=N/N=C(\C)/c2ccc(OC)cc2)/C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K21 compound treatment 1634190.0 -17100.0 -0.08 1368350.0 -99700.0 -0.44 1476670.0 2111.5625 0.0110061359688782 1623270.0 7550.96774193994 0.0364078255133154 -0.2393 -0.5299 1018970 Maybridge1_000417 OC(CNCc1ccccc1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K22 compound treatment 1518100.0 -133000.0 -0.65 1153920.0 -314000.0 -1.39 1446050.0 -28508.4375 -0.148595051950992 1480640.0 -135079.03225806 -0.651298483192232 -1.4224 -0.8483 2069585 Maybridge1_000418 COc1cc(/C=N/Nc2ccccc2)ccc1OC(=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K23 mock treatment 1695170.0 43800.0 0.21 1533070.0 65000.0 0.29 1412660.0 -61898.4375 -0.322634361704241 1536700.0 -79019.0322580601 -0.380998997347508 -0.1003 -0.1631 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 K24 mock treatment 1651790.0 455.0 0.0 1620420.0 152000.0 0.68 1573180.0 98621.5625 0.5140469800625 1566680.0 -49039.0322580601 -0.236447113907893 0.4778 0.5421 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L01 compound treatment 1418690.0 -233000.0 -1.14 1584890.0 117000.0 0.52 1522320.0 47761.5625 0.248948468710292 1381300.0 -234419.03225806 -1.13027727241476 -0.7507 -0.4405 1429726 Maybridge1_000419 CC(=O)N1N=C(OC1(C)C)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L02 compound treatment 1221320.0 -430000.0 -2.1 1406480.0 -61500.0 -0.27 1363560.0 -110998.4375 -0.578559192757984 1233280.0 -382439.03225806 -1.8439720618321 -2.3999 -0.8362 2069586 Maybridge1_000420 Cc1cc(C)c(NS(=O)(=O)c2cc(ccc2C)[N+](=O)[O-])c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L03 compound treatment 1581890.0 -69400.0 -0.34 1448720.0 -19300.0 -0.09 1537180.0 62621.5625 0.326403519412097 1524000.0 -91719.0322580601 -0.442233450972695 -0.2706 -0.4152 2069587 Maybridge1_000421 COc1cc(/C=N/CC\N=C\c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L04 compound treatment 1282880.0 -368000.0 -1.8 1353630.0 -114000.0 -0.51 1382630.0 -91928.4375 -0.479160281796785 1168490.0 -447229.03225806 -2.15636420753099 -2.4729 -0.8539 2069588 Maybridge1_000422 COc1ccc(cc1)c2nnc(S)n2c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L05 compound treatment 1434560.0 -217000.0 -1.06 1531470.0 63400.0 0.28 1543610.0 69051.5625 0.359918726411599 1135780.0 -479939.03225806 -2.31407908769476 -1.3668 -0.5285 2069589 Maybridge1_000423 CC1CCCCC21SCc3cc(C)c(C)cc3CS2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L06 compound treatment 1378080.0 -273000.0 -1.34 1545160.0 77100.0 0.34 1567360.0 92801.5625 0.483711287257351 1228270.0 -387449.03225806 -1.86812833054566 -1.1897 -0.5015 2069590 Maybridge1_000424 CCCC(C)(SCC(=O)O)SCC(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L07 compound treatment 1641440.0 -9890.0 -0.05 1294470.0 -174000.0 -0.77 1459940.0 -14618.4375 -0.0761959500500451 1501800.0 -113919.03225806 -0.549273204553731 -0.7218 -0.7599 1367544 Maybridge1_000425 COc1ccc(NC(=O)C)c(NC(=O)c2c(C)onc2c3ccccc3Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L08 compound treatment 1269280.0 -382000.0 -1.87 1410560.0 -57500.0 -0.25 1417150.0 -57408.4375 -0.299231052306454 1136650.0 -479069.03225806 -2.30988428654091 -2.3668 -0.7896 2069591 Maybridge1_000426 FC(F)(F)c1cccc(NC(=S)N2CCCc3ccccc23)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L09 compound treatment 1428210.0 -223000.0 -1.09 1509280.0 41300.0 0.18 1306000.0 -168558.4375 -0.878580237064573 1148650.0 -467069.03225806 -2.25202496028089 -2.0197 -0.7597 1178859 Maybridge1_000427 C1Oc2ccc(cc2O1)C3Nc4cccc5cccc(N3)c45 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L10 compound treatment 1533360.0 -118000.0 -0.58 1473870.0 5850.0 0.03 1458590.0 -15968.4375 -0.0832325798244352 1232880.0 -382839.03225806 -1.84590070604077 -1.2403 -0.6406 2069592 Maybridge1_000428 COc1cc(/C=N/NC(=O)CCc2ccc(O)cc2)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L11 compound treatment 1104010.0 -547000.0 -2.68 1314300.0 -154000.0 -0.68 1246980.0 -227578.4375 -1.18621126616421 1036340.0 -579379.03225806 -2.79354003796945 -3.6699 -0.8941 1177022 Maybridge1_000429 COc1cccc(Nc2nc3ccccc3s2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L12 compound treatment 1458570.0 -193000.0 -0.94 1601220.0 133000.0 0.59 1467930.0 -6628.4375 -0.0345495264223584 1393470.0 -222249.03225806 -1.07159827236606 -0.7294 -0.472 2069593 Maybridge1_000430 Cc1ccccc1NC(=S)NNC(=O)CCc2ccc(O)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L13 compound treatment 1571050.0 -80300.0 -0.39 1416050.0 -52000.0 -0.23 1536350.0 61791.5625 0.322077295180435 1677080.0 61360.9677419399 0.295858687684286 -0.0027 -0.0043 1242977 Maybridge1_000431 CC1CC(=O)Nc2ccccc2N1C(=O)c3cccc(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L14 compound treatment 1572030.0 -79300.0 -0.39 1316640.0 -151000.0 -0.67 1382620.0 -91938.4375 -0.479212404980299 1275200.0 -340519.03225806 -1.64185014876376 -1.5902 -0.8468 2069594 Maybridge1_000432 Clc1ccc(CNC(=O)c2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L15 compound treatment 1723640.0 72300.0 0.35 1492640.0 24600.0 0.11 1549770.0 75211.5625 0.392026607456224 1481510.0 -134209.03225806 -0.647103682038381 0.104 0.1234 2069595 Maybridge1_000433 C(/N=C/c1ccc2OCOc2c1)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L16 compound treatment 1513080.0 -138000.0 -0.68 1495530.0 27500.0 0.12 1534240.0 59681.5625 0.311079303458981 1475100.0 -140619.03225806 -0.678010205482275 -0.4607 -0.4542 1485674 Maybridge1_000434 Oc1ccc(CCc2nnc(S)n2c3ccc(Cl)cc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L17 compound treatment 1559240.0 -92100.0 -0.45 1505800.0 37800.0 0.17 1299360.0 -175198.4375 -0.913190030917869 1527600.0 -88119.0322580601 -0.42487565309469 -0.8106 -0.7263 2069596 Maybridge1_000435 Cc1ccc(SCC(=O)c2cccc(c2)[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L18 compound treatment 1194340.0 -457000.0 -2.24 1077140.0 -391000.0 -1.73 1078080.0 -396478.4375 -2.06657183571568 1239040.0 -376679.03225806 -1.81619958522729 -3.9263 -0.9949 2069597 Maybridge1_000436 Cc1ccc(/N=C/c2cc(Cl)cc(Cl)c2O)cc1NS(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L19 compound treatment 1699840.0 48500.0 0.24 1322790.0 -145000.0 -0.64 1484960.0 10401.5625 0.0542162551019849 1692160.0 76440.9677419399 0.368568574351044 0.008 0.0103 2069598 Maybridge1_000437 Cc1ccc2nc(C)oc(=O)c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L20 compound treatment 1665720.0 14400.0 0.07 1247890.0 -220000.0 -0.98 1308280.0 -166278.4375 -0.866696151223381 1386940.0 -228779.03225806 -1.10308338907255 -1.4378 -0.8406 2069599 Maybridge1_000438 CN(C)c1ccc(/C=N/c2cc(NS(=O)(=O)C)ccc2C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L21 compound treatment 1334200.0 -317000.0 -1.55 1216080.0 -252000.0 -1.12 1242600.0 -231958.4375 -1.20904122054334 1239090.0 -376629.03225806 -1.81595850470121 -2.8471 -0.9814 1294233 Maybridge1_000439 Cc1ccc2N(CCCc2c1)C(=O)c3sc4ccccc4c3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L22 compound treatment 1621230.0 -30100.0 -0.15 1291520.0 -177000.0 -0.78 1396850.0 -77708.4375 -0.405041114839876 1458890.0 -156829.03225806 -0.756168512038517 -1.0456 -0.8933 2069600 Maybridge1_000440 COc1cc(/C=N/c2ccc(cc2)N3N=C(C)CC3=O)ccc1O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L23 mock treatment 1684500.0 33200.0 0.16 1655550.0 188000.0 0.83 1582560.0 108001.5625 0.562938526198632 1200800.0 -414919.03225806 -2.00057797157589 -0.2219 -0.0989 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 L24 mock treatment 1675530.0 24200.0 0.12 1413560.0 -54500.0 -0.24 1413250.0 -61308.4375 -0.319559093876915 1628390.0 12670.9677419399 0.061094471384257 -0.1908 -0.452 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M01 compound treatment 1503680.0 -148000.0 -0.72 1526240.0 58200.0 0.26 1510470.0 35911.5625 0.187182496246201 1457460.0 -158259.03225806 -0.763063415084503 -0.5201 -0.4736 1610519 Maybridge1_000441 Cc1nc(nc(N2CCN(CCO)CC2)c1Cl)c3ccccn3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M02 compound treatment 1650500.0 -835.0 0.0 1356260.0 -112000.0 -0.5 1577180.0 102621.5625 0.5348962534681 1551210.0 -64509.0322580601 -0.311037428678101 -0.1379 -0.174 2069601 Maybridge1_000442 COc1ccccc1NC(=O)NC2CCN(CC2)c3nccc(n3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M03 compound treatment 1291110.0 -360000.0 -1.76 1500340.0 32300.0 0.14 1488680.0 14121.5625 0.0736060793691931 1209990.0 -405729.03225806 -1.95626737088175 -1.751 -0.6637 1254354 Maybridge1_000443 C1CNCCN(C1)c2nc(ns2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M04 compound treatment 1440870.0 -210000.0 -1.03 1487210.0 19200.0 0.09 1413700.0 -60858.4375 -0.317213550618785 1375060.0 -240659.03225806 -1.16036412206997 -1.2112 -0.7637 1391909 Maybridge1_000444 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCN(CC2)C(=O)OC(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M05 compound treatment 1597280.0 -54100.0 -0.26 1515720.0 47700.0 0.21 1520880.0 46321.5625 0.241442730284276 1430460.0 -185259.03225806 -0.893246899169547 -0.3524 -0.3576 2069602 Maybridge1_000445 [O-][N+](=O)c1ccc(nc1)N2CCCNCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M06 compound treatment 1469680.0 -182000.0 -0.89 1619040.0 151000.0 0.67 1604640.0 130081.5625 0.678026515397546 1311570.0 -304149.03225806 -1.46648817409069 -0.5038 -0.2568 1581293 Maybridge1_000446 C1CN(CCN1)c2ncnc3scc(c4ccccc4)c23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M07 compound treatment 1325120.0 -326000.0 -1.6 1261450.0 -207000.0 -0.92 1412110.0 -62448.4375 -0.325501136797511 1159390.0 -456329.03225806 -2.20024086327817 -2.5191 -0.8726 1364451 Maybridge1_000447 Clc1ccc(CN2CCCN(CC2)C(=O)Nc3cccc(Cl)c3Cl)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M08 compound treatment 1462280.0 -189000.0 -0.93 1358320.0 -110000.0 -0.49 1522450.0 47891.5625 0.249626070095974 1393790.0 -221929.03225806 -1.07005535699912 -1.116 -0.7359 1658768 Maybridge1_000448 Cc1nc(nc(N2CCN(CC2)c3ncnc4scc(c5ccccc5)c34)c1Cl)c6ccccn6 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M09 compound treatment 1345370.0 -306000.0 -1.5 1234720.0 -233000.0 -1.03 1446560.0 -27998.4375 -0.145936769591778 1418400.0 -197319.03225806 -0.951395522060866 -1.8146 -0.8814 2069603 Maybridge1_000449 OC(CNCCNc1ncccc1C(F)(F)F)COc2ccc(Cl)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M10 compound treatment 1335040.0 -316000.0 -1.55 1297630.0 -170000.0 -0.76 1433440.0 -41118.4375 -0.214322386362147 1191080.0 -424639.03225806 -2.0474440258465 -2.2826 -0.8504 2069604 Maybridge1_000450 CC(=O)c1ccc(OCc2c(F)cccc2Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M11 compound treatment 1449990.0 -201000.0 -0.99 1460260.0 -7760.0 -0.03 1601190.0 126631.5625 0.660044017085216 1536110.0 -79609.0322580601 -0.383843747555292 -0.3717 -0.2981 2069605 Maybridge1_000451 FC(F)(F)c1ccnc(NCCNC(=O)c2ccco2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M12 compound treatment 1182800.0 -469000.0 -2.29 952480.0 -516000.0 -2.29 895730.0 -578828.4375 -3.01703808709348 1258830.0 -356889.03225806 -1.72077991300347 -4.6584 -0.981 1301777 Maybridge1_000452 Nc1oc(cc1C#N)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M13 compound treatment 1606570.0 -44800.0 -0.22 1667680.0 200000.0 0.89 1365920.0 -108638.4375 -0.56625812144868 1456490.0 -159229.03225806 -0.767740377290521 -0.3338 -0.2529 1198042 Maybridge1_000453 S=C(NC1CCN(Cc2ccccc2)CC1)Nc3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M14 compound treatment 1608010.0 -43300.0 -0.21 1333290.0 -135000.0 -0.6 1574400.0 99841.5625 0.520406008451208 1428450.0 -187269.03225806 -0.9029383363181 -0.596 -0.4886 2069606 Maybridge1_000454 CCCCCc1ccc(cc1)C(=O)O/N=C/c2c(Cl)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M15 compound treatment 1382690.0 -269000.0 -1.31 1076290.0 -392000.0 -1.74 1304660.0 -169898.4375 -0.885564743655449 1290620.0 -325099.03225806 -1.56750091451964 -2.7524 -0.9739 1500883 Maybridge1_000455 CCCc1cnc(nc1)N2CCCN(CC2)C(=S)Nc3ccc(C)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M16 compound treatment 1599260.0 -52100.0 -0.25 1553070.0 85000.0 0.38 1601120.0 126561.5625 0.659679154800618 1489120.0 -126599.03225806 -0.610411225968485 0.0858 0.0852 1229893 Maybridge1_000456 COc1cccc(NC(=S)NCc2ccco2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M17 compound treatment 1685640.0 34300.0 0.17 1432830.0 -35200.0 -0.16 1550940.0 76381.5625 0.398125019927362 1540840.0 -74879.0322580601 -0.361037529787801 0.0244 0.0418 2069607 Maybridge1_000457 FC(F)(F)c1cnc(NCCCN2C(=O)CC3(CCCC3)C2=O)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M18 compound treatment 1481390.0 -170000.0 -0.83 1480320.0 12300.0 0.05 1341050.0 -133508.4375 -0.695888478848 1405760.0 -209959.03225806 -1.01234067905475 -1.2427 -0.8371 1497535 Maybridge1_000458 OC1(CC(=O)c2ccc3ccccc3c2)C(=O)Nc4ccc(Br)cc41 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M19 compound treatment 1544320.0 -107000.0 -0.52 1561290.0 93300.0 0.41 1647270.0 172711.5625 0.900227646717731 1506570.0 -109149.03225806 -0.526274122365374 0.1319 0.1066 2069608 Maybridge1_000459 Cc1nc(ccc1NC(=O)N2CCCN(Cc3c(F)cccc3Cl)CC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M20 compound treatment 1546400.0 -105000.0 -0.51 1394050.0 -74000.0 -0.33 1576660.0 102101.5625 0.532185847925372 1473010.0 -142709.03225806 -0.688087371472561 -0.4987 -0.4696 1920853 Maybridge1_000460 C/C(=N\N=C(/C)\c1ccc(F)cc1)/c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M21 compound treatment 1595860.0 -55500.0 -0.27 1439260.0 -28800.0 -0.13 1394880.0 -79678.4375 -0.415309381992134 1481440.0 -134279.03225806 -0.647441194774898 -0.7309 -0.8853 1742985 Maybridge1_000461 COc1ccccc1C2CCN(CC2)c3ncnc4scc(c5ccccc5)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M22 compound treatment 1624320.0 -27000.0 -0.13 1504550.0 36500.0 0.16 1439800.0 -34758.4375 -0.181172041647243 1541950.0 -73769.0322580601 -0.35568554210875 -0.2535 -0.5626 2069609 Maybridge1_000462 COC(=O)c1sc2ccccc2c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M23 mock treatment 1692770.0 41400.0 0.2 1633920.0 166000.0 0.74 1526430.0 51871.5625 0.270371097134546 1694350.0 78630.9677419399 0.379127901393497 0.794 0.8881 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 M24 mock treatment 1675150.0 23800.0 0.12 1406900.0 -61100.0 -0.27 1378640.0 -95918.4375 -0.499957432018871 1624180.0 8460.96774193994 0.0407954910880336 -0.3068 -0.5273 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N01 compound treatment 1512160.0 -139000.0 -0.68 1530560.0 62500.0 0.28 1503410.0 28851.5625 0.150383528685316 1234580.0 -381139.03225806 -1.83770396815393 -1.0455 -0.5267 1061248 Maybridge1_000463 CC(=NNC(=O)c1cccnc1)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N02 compound treatment 1572640.0 -78700.0 -0.39 1558800.0 90800.0 0.4 1604880.0 130321.5625 0.679277471801882 1470050.0 -145669.03225806 -0.702359338616699 -0.0028 -0.0025 2069610 Maybridge1_000464 Fc1ccc(NC(=O)CSC(=O)c2sc3ccccc3c2Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N03 compound treatment 1498580.0 -153000.0 -0.75 1495860.0 27800.0 0.12 1521120.0 46561.5625 0.242693686688612 1406940.0 -208779.03225806 -1.00665117863919 -0.694 -0.5409 1918851 Maybridge1_000465 C(C/N=C/c1ccc2OCOc2c1)/N=C/c3ccc4OCOc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N04 compound treatment 1233150.0 -418000.0 -2.05 1180600.0 -287000.0 -1.27 1206440.0 -268118.4375 -1.39751865212996 1192720.0 -422999.03225806 -2.03953658459097 -3.379 -0.9785 2069611 Maybridge1_000466 COc1ccc(cc1)c2nnc(S)n2c3ccc(Cl)cc3C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N05 compound treatment 1473000.0 -178000.0 -0.87 1497760.0 29700.0 0.13 1607410.0 132851.5625 0.692464637230924 1418720.0 -196999.03225806 -0.949852606693932 -0.4991 -0.3395 1155620 Maybridge1_000467 Cc1ccc2nc(oc(=O)c2c1)c3sc4ccccc4c3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N06 compound treatment 1357620.0 -294000.0 -1.44 1284550.0 -183000.0 -0.81 1379220.0 -95338.4375 -0.496934287375059 1277010.0 -338709.03225806 -1.63312303371955 -2.1905 -0.9222 1731343 Maybridge1_000468 COc1ccc(CC2N(CCc3cc(OC)c(OC)cc23)C(=S)Nc4ccc(Cl)cc4C)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N07 compound treatment 1561950.0 -89400.0 -0.44 1371650.0 -96400.0 -0.43 1606880.0 132321.5625 0.689702108504682 1297500.0 -318219.03225806 -1.53432823413056 -0.8547 -0.4775 1680835 Maybridge1_000469 COc1cccc(NC(=S)Nc2ccc(OC)c(OC)c2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N08 compound treatment 1384820.0 -267000.0 -1.3 1316710.0 -151000.0 -0.67 1545970.0 71411.5625 0.372219797720904 1162240.0 -453479.03225806 -2.18649927329141 -1.8947 -0.7126 1443259 Maybridge1_000470 Cc1cccc2CCCN(C(=S)Nc3ccccc3Cl)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N09 compound treatment 1461600.0 -190000.0 -0.93 1314200.0 -154000.0 -0.68 1491430.0 16871.5625 0.0879399548355433 1180750.0 -434969.03225806 -2.09725126253533 -1.81 -0.7559 1532986 Maybridge1_000471 CCOC(=O)C1CCN(CC1)C(=S)Nc2cccc(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N10 compound treatment 1483480.0 -168000.0 -0.82 1462580.0 -5440.0 -0.02 1500880.0 26321.5625 0.137196363256274 1170770.0 -444949.03225806 -2.14537093554158 -1.4268 -0.62 2069612 Maybridge1_000472 Oc1ccc(CCC(=O)N/N=C/C=C/c2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N11 compound treatment 1658110.0 6780.0 0.03 1390560.0 -77500.0 -0.34 1581300.0 106741.5625 0.556371005075868 1444610.0 -171109.03225806 -0.825021110287941 -0.2895 -0.2749 1025368 Maybridge1_000473 CC1CC(=O)Nc2ccccc2N1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N12 compound treatment 1475040.0 -176000.0 -0.86 1443360.0 -24700.0 -0.11 1332320.0 -142238.4375 -0.741392018055723 1462560.0 -153159.03225806 -0.738473201423995 -1.226 -0.9011 2069613 Maybridge1_000474 Fc1ccc(cc1)N(Cc2ccc3OCOc3c2)C(=S)Nc4ccc(Cl)c(Cl)c4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N13 compound treatment 1587360.0 -64000.0 -0.31 1542130.0 74100.0 0.33 1516770.0 42211.5625 0.220020101860021 1503360.0 -112359.03225806 -0.541751492139929 -0.1531 -0.2068 1356457 Maybridge1_000475 CC1CC(=O)Nc2ccccc2N1C(=O)c3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N14 compound treatment 1363610.0 -288000.0 -1.41 1346560.0 -121000.0 -0.54 1407690.0 -66868.4375 -0.348539583910699 1310180.0 -305539.03225806 -1.47319021271581 -1.8842 -0.8819 2069614 Maybridge1_000476 Oc1c(Cl)cc(Cl)cc1/C=N/Cc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N15 compound treatment 1050980.0 -600000.0 -2.94 986630.0 -481000.0 -2.13 964100.0 -510458.4375 -2.66067188140826 969690.0 -646029.03225806 -3.11490037923864 -5.4241 -0.9908 2069615 Maybridge1_000477 Clc1cc(Cl)cc(/C=N/Cc2ccccc2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N16 compound treatment 1708080.0 56700.0 0.28 1398760.0 -69300.0 -0.31 1619240.0 144681.5625 0.754126363327987 1637170.0 21450.9677419399 0.103428211764505 0.414 0.4778 2069616 Maybridge1_000478 Oc1ccc(CCc2nnc(S)n2c3cccc(c3)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N17 compound treatment 1509130.0 -142000.0 -0.7 1190080.0 -278000.0 -1.23 1139810.0 -334748.4375 -1.74481542388375 1282250.0 -333469.03225806 -1.607857794586 -2.6406 -0.9558 1635176 Maybridge1_000479 COc1ccc(CN(Cc2ccccc2)C(=S)Nc3c(C)cccc3C)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N18 compound treatment 1663200.0 11900.0 0.06 1352020.0 -116000.0 -0.51 1513860.0 39301.5625 0.204852255457447 1456380.0 -159339.03225806 -0.768270754447905 -0.5099 -0.5374 2069617 Maybridge1_000480 Cc1ccc(NS(=O)(=O)C)cc1NC(=S)Nc2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N19 compound treatment 1587360.0 -64000.0 -0.31 1612000.0 144000.0 0.64 1693880.0 219321.5625 1.14317380507649 1577400.0 -38319.0322580601 -0.184759449115609 0.6419 0.4724 1041825 Maybridge1_000481 COC(=O)c1cccc([N+](=O)[O-])c1C(=O)OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N20 compound treatment 1586250.0 -65100.0 -0.32 1418330.0 -49700.0 -0.22 1429020.0 -45538.4375 -0.237360833475335 1444290.0 -171429.03225806 -0.826564025654874 -0.8014 -0.8497 1733240 Maybridge1_000482 Cc1ccc(NS(=O)(=O)C)cc1NC(=S)Nc2cccc(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N21 compound treatment 1122500.0 -529000.0 -2.59 924580.0 -543000.0 -2.41 945710.0 -528848.4375 -2.75652641589051 1064290.0 -551429.03225806 -2.65877602388882 -5.2066 -0.9988 1669077 Maybridge1_000483 Cc1onc(c1C(=O)N2CCCc3cc(C)ccc23)c4c(Cl)cccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N22 compound treatment 1707680.0 56300.0 0.28 1527850.0 59800.0 0.27 1520480.0 45921.5625 0.239357802943716 1535090.0 -80629.0322580601 -0.388761790287394 0.1958 0.3287 2069618 Maybridge1_000484 CC1=NN(C(=O)C1)c2ccc(/N=C/c3ccc(Cl)c(Cl)c3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N23 mock treatment 1688080.0 36700.0 0.18 1651200.0 183000.0 0.81 1611860.0 137301.5625 0.715659453894655 1704060.0 88340.9677419399 0.425945739558896 1.0669 0.9063 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 N24 mock treatment 1722090.0 70800.0 0.35 1465130.0 -2890.0 -0.01 1347910.0 -126648.4375 -0.660131974957396 1603470.0 -12249.0322580601 -0.0590600628157166 -0.1929 -0.2579 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O01 compound treatment 1214130.0 -437000.0 -2.14 1133280.0 -335000.0 -1.48 1385600.0 -88958.4375 -0.463679696293127 1266990.0 -348729.03225806 -1.68143557114666 -2.8845 -0.9203 1915043 Maybridge1_000485 CCOC(=O)c1c(N)scc1c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O02 compound treatment 1638170.0 -13200.0 -0.06 1533850.0 65800.0 0.29 1525320.0 50761.5625 0.264585423764492 1562110.0 -53609.0322580601 -0.258481873991917 0.1168 0.2456 1150030 Maybridge1_000486 COc1ccccc1NC(=O)N2CCCN(CC2)C(=O)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O03 compound treatment 1469700.0 -182000.0 -0.89 1340810.0 -127000.0 -0.56 1464000.0 -10558.4375 -0.0550339375433607 1394980.0 -220739.03225806 -1.06431764047834 -1.2862 -0.8586 2069619 Maybridge1_000487 c1csc(c1)c2csc(n2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O04 compound treatment 1572960.0 -78400.0 -0.38 1604260.0 136000.0 0.6 1519910.0 45351.5625 0.236386781483418 1353400.0 -262319.03225806 -1.2648002059693 -0.4039 -0.2743 1324207 Maybridge1_000488 COc1ccccc1NC(=O)N2CCN(CC2)C(=O)OC(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O05 compound treatment 1488530.0 -163000.0 -0.8 1523420.0 55400.0 0.25 1637330.0 162771.5625 0.848417202304814 1342690.0 -273029.03225806 -1.31643965465637 -0.5095 -0.2872 1231382 Maybridge1_000489 OC1CCN(CC1)C(=S)NCCc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O06 compound treatment 1595650.0 -55700.0 -0.27 1411410.0 -56600.0 -0.25 1674030.0 199471.5625 1.0397092858012 1313820.0 -301899.03225806 -1.45563955041694 -0.4697 -0.2571 1249375 Maybridge1_000490 Fc1cccc(Cl)c1CN2CCN(CC2)c3ncnc4scc(c5ccccc5)c34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O07 compound treatment 1643370.0 -7960.0 -0.04 1369860.0 -98200.0 -0.44 1604160.0 129601.5625 0.675524602588874 1609690.0 -6029.03225806006 -0.0290696453709399 0.0861 0.1069 2069620 Maybridge1_000491 OC(=O)CSCC(=O)NCCNc1nccc(n1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O08 compound treatment 1161620.0 -490000.0 -2.4 1306900.0 -161000.0 -0.71 1329950.0 -144608.4375 -0.753745212548541 1022570.0 -593149.03225806 -2.85993361485282 -3.3623 -0.8681 2069621 Maybridge1_000492 Brc1ccc(NC(=O)CN2CCN(CC2)c3ncnc4scc(c5ccccc5)c34)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O09 compound treatment 1583960.0 -67400.0 -0.33 1656160.0 188000.0 0.83 1608070.0 133511.5625 0.695904767342848 1208800.0 -406919.03225806 -1.96200508740254 -0.3807 -0.168 2069622 Maybridge1_000493 OCCN1CCN(CC1)c2nccc(n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O10 compound treatment 1342050.0 -309000.0 -1.51 1325240.0 -143000.0 -0.63 1406810.0 -67748.4375 -0.353126424059931 1292390.0 -323329.03225806 -1.55896666389629 -2.0294 -0.886 1549615 Maybridge1_000494 COc1ccc(CCNc2ncnc3scc(c4ccc(C)cc4)c23)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O11 compound treatment 1564610.0 -86700.0 -0.42 1617930.0 150000.0 0.66 1638720.0 164161.5625 0.855662324813261 1601280.0 -14439.0322580601 -0.0696193898581702 0.5132 0.4402 2069623 Maybridge1_000495 FC(F)(F)c1ccnc(NCCNC(=O)c2ccccc2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O12 compound treatment 1683040.0 31700.0 0.16 1577160.0 109000.0 0.48 1668700.0 194141.5625 1.01192762898823 1522450.0 -93269.0322580601 -0.449706947281281 0.6007 0.493 2069624 Maybridge1_000496 FC(F)(F)c1cnc(NCCNC(=O)C2=Cc3cc(Cl)ccc3OC2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O13 compound treatment 1580160.0 -71200.0 -0.35 1520670.0 52600.0 0.23 1612390.0 137831.5625 0.718421982620897 1285280.0 -330439.03225806 -1.59324831470535 -0.4948 -0.2753 1702834 Maybridge1_000497 Cc1cc(c(C)cc1Cl)S(=O)(=O)N2CCCN(Cc3ccc(Cl)cc3Cl)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O14 compound treatment 1667570.0 16200.0 0.08 1616530.0 149000.0 0.66 1552290.0 77731.5625 0.405161649701752 1510670.0 -105049.03225806 -0.506505519226534 0.3183 0.3431 2069625 Maybridge1_000498 CCCCCCCc1ccc(NC(=O)Nc2ccc(F)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O15 compound treatment 1615430.0 -35900.0 -0.18 1468220.0 196.0 0.0 1461520.0 -13038.4375 -0.0679604870548329 1268930.0 -346789.03225806 -1.67208164673463 -0.9574 -0.569 1280161 Maybridge1_000499 CCCc1cnc(nc1)N2CCCN(CC2)C(=S)Nc3ccc(C)cc3C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O16 compound treatment 1690400.0 39100.0 0.19 1586080.0 118000.0 0.52 1564330.0 89771.5625 0.467917962652609 1583680.0 -32039.0322580601 -0.154479735039532 0.5141 0.691 2069626 Maybridge1_000500 Cc1ccccc1NC(=S)NCc2ccco2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O17 compound treatment 1658850.0 7520.0 0.04 1492640.0 24600.0 0.11 1644110.0 169551.5625 0.883756720727307 1505680.0 -110039.03225806 -0.530565355729658 0.2496 0.2406 2069627 Maybridge1_000501 OC(=O)c1ccccc1C(=O)NCCNc2ccc(cn2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O18 compound treatment 1250590.0 -401000.0 -1.96 1074980.0 -393000.0 -1.74 1083700.0 -390858.4375 -2.03727860658081 1204730.0 -410989.03225806 -1.98162904222573 -3.8615 -0.9983 1569206 Maybridge1_000502 CCc1cc2c(cc1C(=O)CC3(O)C(=O)Nc4ccc(Br)cc43)C(C)(C)CCC2(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O19 compound treatment 1247120.0 -404000.0 -1.98 1409190.0 -58800.0 -0.26 1270080.0 -204478.4375 -1.06580671224686 1126910.0 -488809.03225806 -2.35684677302195 -2.8308 -0.8666 2069628 Maybridge1_000503 CCOC(=O)c1c(N)sc(C)c1c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O20 compound treatment 1561620.0 -89700.0 -0.44 1423200.0 -44800.0 -0.2 1398890.0 -75668.4375 -0.39440798540302 1203680.0 -412039.03225806 -1.98669173327348 -1.5094 -0.725 2069629 Maybridge1_000504 Oc1ccccc1/C=N/c2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O21 compound treatment 1647200.0 -4130.0 -0.02 1500890.0 32900.0 0.15 1627740.0 153181.5625 0.798431069314888 1489380.0 -126339.03225806 -0.609157607232851 0.1574 0.1551 1609990 Maybridge1_000505 Clc1ccc(CN2CCCN(CC2)c3ncnc4scc(c5ccccc5)c34)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O22 compound treatment 1120800.0 -531000.0 -2.6 983740.0 -484000.0 -2.15 983300.0 -491258.4375 -2.56059536906138 1036040.0 -579679.03225806 -2.79498652112595 -5.0497 -0.9957 2069630 Maybridge1_000506 NNC(=O)c1sc2ccccc2c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O23 mock treatment 1527150.0 -124000.0 -0.61 1574630.0 107000.0 0.47 1618000.0 143441.5625 0.747663088572251 1666630.0 50910.9677419399 0.245472857732852 0.4291 0.3898 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 O24 mock treatment 1699470.0 48100.0 0.24 1577930.0 110000.0 0.49 1358240.0 -116318.4375 -0.606288726387433 1499170.0 -116549.03225806 -0.561954040225719 -0.2226 -0.2253 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P01 compound treatment 1382170.0 -269000.0 -1.32 1527240.0 59200.0 0.26 1399170.0 -75388.4375 -0.392948536264628 1288440.0 -327279.03225806 -1.57801202545688 -1.5127 -0.7172 2069631 Maybridge1_000507 O=C(N/N=C/c1ccco1)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P02 compound treatment 1643690.0 -7640.0 -0.04 1587270.0 119000.0 0.53 1516370.0 41811.5625 0.217935174519461 1461280.0 -154439.03225806 -0.74464486289173 -0.0176 -0.0188 2069632 Maybridge1_000508 Clc1c(sc2ccccc12)C(=O)SCC(=O)Nc3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P03 compound treatment 1674270.0 22900.0 0.11 1582040.0 114000.0 0.51 1509200.0 34641.5625 0.180562851939923 1488420.0 -127299.03225806 -0.613786353333653 0.0923 0.1122 1982147 Maybridge1_000509 Cc1cc2CSC(SCc2cc1C)c3cc(Cl)cc(Cl)c3O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P04 compound treatment 1569620.0 -81700.0 -0.4 1535850.0 67800.0 0.3 1512160.0 37601.5625 0.195991314260067 1466150.0 -149569.03225806 -0.721163619651206 -0.3121 -0.347 2069633 Maybridge1_000510 COc1ccc(cc1)c2nnc(S)n2c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P05 compound treatment 1653190.0 1860.0 0.01 1501410.0 33400.0 0.15 1564400.0 89841.5625 0.468282824937207 1526150.0 -89569.0322580601 -0.431866988351109 0.0968 0.148 2069634 Maybridge1_000511 Cc1cc(C)c(/N=C/2\SC(=C)C3(CCCCC3)N2C(=O)c4c(Cl)sc5ccccc45)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P06 compound treatment 1623900.0 -27400.0 -0.13 1506460.0 38400.0 0.17 1572110.0 97551.5625 0.508469799426502 1314880.0 -300839.03225806 -1.45052864326397 -0.4529 -0.2918 2069635 Maybridge1_000512 CCCCCCC(C)(SCC(=O)O)SCC(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P07 compound treatment 1497350.0 -154000.0 -0.75 1468340.0 316.0 0.0 1503370.0 28811.5625 0.15017503595126 1486510.0 -129209.03225806 -0.622995629430039 -0.6125 -0.6192 1444113 Maybridge1_000513 COc1ccccc1NC(=S)Nc2ccc(OC)c(OC)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P08 compound treatment 1595150.0 -56200.0 -0.27 1483630.0 15600.0 0.07 1306000.0 -168558.4375 -0.878580237064573 1507630.0 -108089.03225806 -0.521163215212405 -0.8027 -0.7572 2069636 Maybridge1_000514 Cc1ccc2N(CCCc2c1)C(=S)Nc3cccc(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P09 compound treatment 1545450.0 -106000.0 -0.52 1576000.0 108000.0 0.48 1536830.0 62271.5625 0.324579207989107 1344030.0 -271689.03225806 -1.30997869655734 -0.5123 -0.3364 1715015 Maybridge1_000515 CCOC(=O)C1CCN(CC1)C(=S)Nc2cccc(OC)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P10 compound treatment 1093650.0 -558000.0 -2.73 1099330.0 -369000.0 -1.64 1100390.0 -374168.4375 -1.95028501329594 1161280.0 -454439.03225806 -2.19112801939222 -4.2527 -0.9828 2069637 Maybridge1_000516 CN(C)c1ccc(/C=N/NC(=O)CCc2ccc(O)cc2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P11 compound treatment 1616480.0 -34900.0 -0.17 1612160.0 144000.0 0.64 1586270.0 111711.5625 0.582276227282327 1624100.0 8380.96774193994 0.0404097622463001 0.5457 0.6185 2069638 Maybridge1_000517 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc3[nH]cnc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P12 compound treatment 1620430.0 -30900.0 -0.15 1498810.0 30800.0 0.14 1579720.0 105161.5625 0.548135542080656 1583840.0 -31879.0322580601 -0.153708277356065 0.1899 0.314 2069639 Maybridge1_000518 CS(=O)(=O)N1CCCc2ccccc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P13 compound treatment 1543750.0 -108000.0 -0.53 1516610.0 48600.0 0.22 1527400.0 52841.5625 0.275427045935404 1561120.0 -54599.0322580601 -0.263255268408369 -0.1494 -0.2182 2069640 Maybridge1_000519 CC1CC(=O)Nc2ccccc2N1C(=O)c3ccc(cc3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P14 compound treatment 1692210.0 40900.0 0.2 1585390.0 117000.0 0.52 1414100.0 -60458.4375 -0.315128623278225 1474780.0 -140939.03225806 -0.679553120849208 -0.1371 -0.1468 1083099 Maybridge1_000520 CC(=O)c1cc2cc(Cl)cc(Cl)c2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P15 compound treatment 968640.0 -683000.0 -3.34 1053840.0 -414000.0 -1.84 1143840.0 -330718.4375 -1.72380978092761 1084450.0 -531269.03225806 -2.56157235577199 -4.7314 -0.9645 2069641 Maybridge1_000521 Brc1cccc(/C=N/Cc2ccccc2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P16 compound treatment 1687840.0 36500.0 0.18 1546110.0 78100.0 0.35 1626260.0 151701.5625 0.790716838154816 1358900.0 -256819.03225806 -1.23828134810013 0.0387 0.0254 2069642 Maybridge1_000522 Cc1onc(c1NC(=O)NNC(=O)c2c(C)onc2c3ccccc3)c4ccccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P17 compound treatment 1495240.0 -156000.0 -0.76 1538040.0 70000.0 0.31 1548530.0 73971.5625 0.385563332700488 1468830.0 -146889.03225806 -0.708241703453135 -0.388 -0.3364 1164239 Maybridge1_000523 COc1cc(CN(Cc2ccccc2)C(=S)Nc3c(C)cccc3C)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P18 compound treatment 1598240.0 -53100.0 -0.26 1520050.0 52000.0 0.23 1544390.0 69831.5625 0.363984334725691 1440960.0 -174759.03225806 -0.84261998869203 -0.2539 -0.2587 1478744 Maybridge1_000524 Cc1ccc(NS(=O)(=O)C)cc1NC(=S)Nc2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P19 compound treatment 1577290.0 -74000.0 -0.36 1456000.0 -12000.0 -0.05 1472960.0 -1598.4375 -0.00833156511481606 1449600.0 -166119.03225806 -0.800961273784816 -0.6125 -0.6954 2069643 Maybridge1_000525 Fc1ccc(/N=C/c2ccc3OCOc3c2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P20 compound treatment 1545810.0 -106000.0 -0.52 1600700.0 133000.0 0.59 1555120.0 80561.5625 0.419912510636214 1451210.0 -164509.03225806 -0.79319848084493 -0.1506 -0.1265 2069644 Maybridge1_000526 COCCCNC(=S)Nc1ccc(Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P21 compound treatment 1617820.0 -33500.0 -0.16 1520340.0 52300.0 0.23 1566160.0 91601.5625 0.477456505235671 1592260.0 -23459.0322580601 -0.113110316763618 0.2162 0.3813 2069645 Maybridge1_000527 Cc1ccc(cc1Cl)N2C(SCC2=O)c3ccc(Cl)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P22 compound treatment 1465210.0 -186000.0 -0.91 1566240.0 98200.0 0.44 1558560.0 84001.5625 0.43784288576503 1553730.0 -61989.0322580601 -0.298886970163497 -0.1681 -0.1474 2069646 Maybridge1_000528 COCCCNC(=S)Nc1ccc(F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P23 mock treatment 1675950.0 24600.0 0.12 1542350.0 74300.0 0.33 1588440.0 113881.5625 0.593586958104865 1670670.0 54950.9677419399 0.264952164240392 0.6543 0.8857 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.542 P24 mock treatment 1645700.0 -5630.0 -0.03 1540970.0 72900.0 0.32 1524000.0 49441.5625 0.257705163540644 1616040.0 320.967741939938 0.00154758144165371 0.2776 0.6697 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A01 compound treatment 1205790.0 -273000.0 -1.34 1259810.0 -275000.0 -1.22 1297820.0 -334351.33333333 -1.7427455905484 1631440.0 -125970.0 -0.607378277414554 -2.4538 -0.9492 1349488 Maybridge1_000529 CCOC(=O)C1=C(C)N(C(=O)C1CC(=O)Nc2ccc(F)cc2)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A02 compound treatment 1359840.0 -119000.0 -0.58 1346170.0 -189000.0 -0.84 1463520.0 -168651.33333333 -0.879064439721407 1712050.0 -45360.0 -0.218708253262873 -1.2592 -0.9227 2069647 Maybridge1_000530 FC(F)(F)c1cccc(NC(=S)N2CCCCC2CCN3CCOCC3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A03 compound treatment 1288000.0 -191000.0 -0.93 1432560.0 -103000.0 -0.46 1350900.0 -281271.33333333 -1.46607573245608 1772980.0 15570.0 0.0750724758223752 -1.39 -0.7729 1364330 Maybridge1_000531 OC(=O)c1cc2cc(Cl)cc(Cl)c2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A04 compound treatment 1270110.0 -209000.0 -1.02 1288980.0 -246000.0 -1.09 1201280.0 -430891.33333333 -2.24594280419256 1567640.0 -189770.0 -0.914997028696991 -2.6372 -0.9256 2069648 Maybridge1_000532 [O-][N+](=O)c1ccc2NC(NC(=O)c2c1)c3ccc4OCOc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A05 compound treatment 1421410.0 -57400.0 -0.28 1420420.0 -115000.0 -0.51 1495810.0 -136361.33333333 -0.710758680154699 1828590.0 71180.0 0.343202236932349 -0.5788 -0.5904 2069649 Maybridge1_000533 Clc1ccc(/C=N/N=C(\C(=O)c2ccccc2)/c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A06 compound treatment 1409610.0 -69200.0 -0.34 1350830.0 -184000.0 -0.82 1363080.0 -269091.33333333 -1.40258969493603 1756830.0 -580.0 -0.00279653410256761 -1.2809 -0.7723 1933703 Maybridge1_000534 COc1ccc(CCNC(=O)c2ccc(cc2)[N+](=O)[O-])cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A07 compound treatment 1481600.0 2780.0 0.01 1436710.0 -98500.0 -0.44 1482030.0 -150141.33333333 -0.782584427036992 1638200.0 -119210.0 -0.574784190288076 -0.8903 -0.8361 1547043 Maybridge1_000535 Clc1c(sc2ccccc12)C(=O)Nc3ccc4[nH]nnc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A08 compound treatment 1487290.0 8470.0 0.04 1429310.0 -106000.0 -0.47 1488690.0 -143481.33333333 -0.747870386816667 1743780.0 -13630.0 -0.0657185514103387 -0.6209 -0.7004 2069650 Maybridge1_000536 FC(F)(F)c1ccc(N2CCCCC2)c(NC=C(C#N)C#N)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A09 compound treatment 1438880.0 -39900.0 -0.2 1471250.0 -64000.0 -0.28 1384760.0 -247411.33333333 -1.28958663307768 1753670.0 -3740.0 -0.0180328233510394 -0.8934 -0.6692 1471479 Maybridge1_000537 CCOC(=O)c1ccc(cc1)N2CC3CCCCN3C2c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A10 compound treatment 1210120.0 -269000.0 -1.31 1155460.0 -380000.0 -1.68 1236570.0 -395601.33333333 -2.06200008957165 1500230.0 -257180.0 -1.24002179396265 -3.1505 -0.9791 1441228 Maybridge1_000538 COc1cc(CNc2cccc(F)c2)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A11 compound treatment 944400.0 -534000.0 -2.62 880030.0 -655000.0 -2.91 241730.0 -1390441.33333333 -7.24742287827851 931930.0 -825480.0 -3.98014305342674 -8.3742 -0.9156 1248791 Maybridge1_000539 Fc1ccc(NC(=S)Nc2ccc(Cl)cc2C(=O)c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A12 compound treatment 1420080.0 -58700.0 -0.29 1396250.0 -139000.0 -0.62 1381350.0 -250821.33333333 -1.30736063865595 1669360.0 -88050.0 -0.424542806432893 -1.3178 -0.8593 1664786 Maybridge1_000540 CCOC(=O)c1c[nH]c2c(F)cccc2c1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A13 compound treatment 1449710.0 -29100.0 -0.14 1460490.0 -74700.0 -0.33 1552960.0 -79211.33333333 -0.412874686372185 1744490.0 -12920.0 -0.0622952079399543 -0.4745 -0.86 2069651 Maybridge1_000541 COc1cccc(C2SCc3cc(C)c(C)cc3CS2)c1O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A14 compound treatment 1420640.0 -58200.0 -0.28 1329450.0 -206000.0 -0.91 1315840.0 -316331.33333333 -1.64881961385617 1444070.0 -313340.0 -1.51080344085954 -2.1785 -0.8957 2069652 Maybridge1_000542 COc1c(/N=C/c2cc(Br)ccc2O)c(C)c(/N=C/c3cc(Br)ccc3O)cc1C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A15 compound treatment 1282920.0 -196000.0 -0.96 1361120.0 -174000.0 -0.77 1285120.0 -347051.33333333 -1.80894203361118 1503480.0 -253930.0 -1.22435155976723 -2.382 -0.95 2069653 Maybridge1_000543 COc1ccccc1/N=C\2/NC(C)(C)C(=C)S2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A16 compound treatment 1321680.0 -157000.0 -0.77 1372980.0 -162000.0 -0.72 1272320.0 -359851.33333333 -1.8756597085091 1482480.0 -274930.0 -1.32560538072226 -2.3449 -0.928 1304585 Maybridge1_000544 Clc1ccc(Cl)c(NC(=S)N(CCc2ccccc2)CCc3ccccn3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A17 compound treatment 1332280.0 -147000.0 -0.72 1377780.0 -157000.0 -0.7 1341570.0 -290601.33333333 -1.51470666267465 1675910.0 -81500.0 -0.392961257515965 -1.6615 -0.8945 2069654 Maybridge1_000545 FC(F)(F)c1cc(NC(=O)c2cc3ccccc3oc2=O)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A18 compound treatment 331250.0 -1150000.0 -5.62 397690.0 -1140000.0 -5.04 45820.0 -1586351.33333333 -8.26856816650129 412030.0 -1345380.0 -6.48689836364208 -12.7079 -0.9821 2069655 Maybridge1_000546 [O-][N+](=O)c1ccc(C=C2C(=O)NC(=S)NC2=O)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A19 compound treatment 1355130.0 -124000.0 -0.61 1441120.0 -94100.0 -0.42 1515840.0 -116331.33333333 -0.606355943576155 1607690.0 -149720.0 -0.721891527304176 -1.1754 -0.9832 1673765 Maybridge1_000547 CC(=O)Nc1ccc(C)c(NC(=S)Nc2ccc(Cl)cc2C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A20 compound treatment 1420410.0 -58400.0 -0.29 1436200.0 -99000.0 -0.44 1496060.0 -136111.33333333 -0.709455600566849 1522880.0 -234530.0 -1.13081231564686 -1.2826 -0.8944 1676755 Maybridge1_000548 Cc1ncc(CSCC(=O)Nc2ccccc2F)c(CO)c1O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A21 compound treatment 1113120.0 -366000.0 -1.79 1179250.0 -356000.0 -1.58 1275430.0 -356741.33333333 -1.85944939843625 1328840.0 -428570.0 -2.06639762127138 -3.647 -0.9955 1714954 Maybridge1_000549 CC(C)c1ccc(cc1)N(CCc2ccccn2)C(=O)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A22 compound treatment 954720.0 -524000.0 -2.56 1283680.0 -252000.0 -1.12 1412160.0 -220011.33333333 -1.14676911024932 1205540.0 -551870.0 -2.66090219859308 -3.7439 -0.9297 2069656 Maybridge1_000550 Cc1ccc(cc1)S(=O)(=O)N/N=C/c2ccc(Cl)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A23 mock treatment 1453180.0 -25600.0 -0.13 1513350.0 -21900.0 -0.1 1594820.0 -37351.33333333 -0.194687040182577 1579870.0 -177540.0 -0.856028732016987 -0.6366 -0.7136 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 A24 mock treatment 1440330.0 -38500.0 -0.19 1406650.0 -129000.0 -0.57 1571950.0 -60221.33333333 -0.313892760879097 1599410.0 -158000.0 -0.761814462423589 -0.9171 -0.8995 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B01 compound treatment 1529790.0 51000.0 0.25 1355520.0 -180000.0 -0.8 1490080.0 -142091.33333333 -0.740625264308221 1820990.0 63580.0 0.30655799696767 -0.4908 -0.424 1706179 Maybridge1_000551 Clc1ccc(cc1Cl)C2N(Cc3ccccc3)CCC4CCCCN24 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B02 compound treatment 1461500.0 -17300.0 -0.08 1456720.0 -78500.0 -0.35 1608330.0 -23841.33333333 -0.124268619255162 1905330.0 147920.0 0.713212628365173 0.078 0.0966 2069657 Maybridge1_000552 [O-][N+](=O)c1cc(Cl)c(cc1N2CCCCC2)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B03 compound treatment 1461080.0 -17700.0 -0.09 1396810.0 -138000.0 -0.61 1570300.0 -61871.33333333 -0.322493086158907 1747150.0 -10260.0 -0.0494697239523166 -0.5363 -0.7655 2069658 Maybridge1_000553 CCC(C(=O)NNC(=O)c1ccccc1N)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B04 compound treatment 1031690.0 -447000.0 -2.19 1133030.0 -402000.0 -1.78 1116680.0 -515491.33333333 -2.68690493672101 1413690.0 -343720.0 -1.65728396850782 -4.1579 -0.9818 1375753 Maybridge1_000554 Clc1cc(Cl)c(cc1Cl)S(=O)(=O)Nc2cccc3cccnc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B05 compound treatment 1227680.0 -251000.0 -1.23 1270240.0 -265000.0 -1.18 1206840.0 -425331.33333333 -2.21696231415878 1590260.0 -167150.0 -0.805932198696854 -2.7135 -0.9332 2069659 Maybridge1_000555 [O-][N+](=O)c1ccccc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B06 compound treatment 1438490.0 -40300.0 -0.2 1435360.0 -99900.0 -0.44 1378590.0 -253581.33333333 -1.32174663730582 1749600.0 -7810.0 -0.0376567781742293 -0.9998 -0.7099 2069660 Maybridge1_000556 CC1(C)CCC(C)(C)N=C(N1)SCC(=O)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B07 compound treatment 1323740.0 -155000.0 -0.76 1408580.0 -127000.0 -0.56 1230330.0 -401841.33333333 -2.09452495608439 1673820.0 -83590.0 -0.403038423506252 -1.9091 -0.8184 2069661 Maybridge1_000557 COc1cc([N+](=O)[O-])c(OC)cc1SCC(=O)NNC(=S)Nc2cccc(Cl)c2C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B08 compound treatment 1410400.0 -68400.0 -0.33 1541850.0 6620.0 0.03 1329360.0 -302811.33333333 -1.57834906974524 1379520.0 -377890.0 -1.82203840003323 -1.8529 -0.7613 2069662 Maybridge1_000558 Clc1ccc(cc1)S(=O)(=O)Nc2cccc(C#N)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B09 compound treatment 1485460.0 6640.0 0.03 1515570.0 -19700.0 -0.09 1416610.0 -215561.33333333 -1.12357429358558 1836850.0 79440.0 0.383028739841329 -0.3976 -0.3339 2069663 Maybridge1_000559 COc1cc([N+](=O)[O-])c(OC)cc1SCc2nnc(S)n2c3cccc(Cl)c3C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B10 compound treatment 1494530.0 15700.0 0.08 1516720.0 -18500.0 -0.08 1550500.0 -81671.33333333 -0.425696989516629 1785620.0 28210.0 0.136017632816262 -0.1475 -0.32 2069664 Maybridge1_000560 Cc1cccc(C)c1NC(=O)CSC(=O)c2ccc(cc2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B11 compound treatment 1490670.0 11900.0 0.06 1359790.0 -175000.0 -0.78 1330980.0 -301191.33333333 -1.56990511401597 1688070.0 -69340.0 -0.334330473572479 -1.3121 -0.7352 2069665 Maybridge1_000561 OCc1ccc(N2CCOCC2)c(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B12 compound treatment 1448710.0 -30100.0 -0.15 1529320.0 -5910.0 -0.03 1515200.0 -116971.33333333 -0.609691827321051 1810500.0 53090.0 0.255979302595369 -0.2636 -0.3889 2069666 Maybridge1_000562 [O-][N+](=O)c1cccc(c1)c2noc(n2)c3c(F)cccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B13 compound treatment 1302370.0 -176000.0 -0.86 1481200.0 -54000.0 -0.24 1486560.0 -145611.33333333 -0.75897262490515 1542520.0 -214890.0 -1.0361158850013 -1.4491 -0.9253 2069667 Maybridge1_000563 Cc1ccc(cc1)S(=O)(=O)NNC(=O)CCc2nc(no2)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B14 compound treatment 1457280.0 -21500.0 -0.11 1470760.0 -64500.0 -0.29 1444360.0 -187811.33333333 -0.978932459334233 1432640.0 -324770.0 -1.56591444912221 -1.4681 -0.7844 2069668 Maybridge1_000564 Cc1cc(Oc2ccc(cc2)[N+](=O)[O-])c(Cl)c(C)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B15 compound treatment 1452870.0 -25900.0 -0.13 1538690.0 3460.0 0.02 1439850.0 -192321.33333333 -1.00244001509905 1668240.0 -89170.0 -0.429943010217161 -0.772 -0.703 2069669 Maybridge1_000565 COC(=O)c1cc(ccc1n2cccc2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B16 compound treatment 1510400.0 31600.0 0.15 1490940.0 -44300.0 -0.2 1524420.0 -107751.33333333 -0.561634252121143 1700020.0 -57390.0 -0.276712227838543 -0.4401 -0.6529 1590064 Maybridge1_000566 CC(C)(C#C)N1CNC(=S)NC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B17 compound treatment 1391880.0 -86900.0 -0.43 1409550.0 -126000.0 -0.56 1479630.0 -152541.33333333 -0.795093991080352 1588000.0 -169410.0 -0.816829038475824 -1.2974 -0.9694 2069670 Maybridge1_000567 Sc1nc2cc(Cl)c(Cl)cc2[nH]1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B18 compound treatment 1515580.0 36800.0 0.18 1460210.0 -75000.0 -0.33 1553120.0 -79051.33333333 -0.41204071543596 1565440.0 -191970.0 -0.925604571844661 -0.7452 -0.6891 2069671 Maybridge1_000568 [O-][N+](=O)c1ccc(cc1)C(=O)Oc2ccc(Cl)cc2Sc3cc(Cl)ccc3OC(=O)c4ccc(cc4)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B19 compound treatment 1441670.0 -37100.0 -0.18 1342140.0 -193000.0 -0.86 1602040.0 -30131.33333333 -0.157054101685469 1386830.0 -370580.0 -1.78679242711983 -1.491 -0.747 2069672 Maybridge1_000569 C/C(=N\NC1=NCCN1Cc2ccccc2)/c3ccc(C)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B20 compound treatment 1460050.0 -18800.0 -0.09 1531850.0 -3380.0 -0.02 1615300.0 -16871.33333333 -0.0879387603459038 1700690.0 -56720.0 -0.273481748789025 -0.2341 -0.7754 2069673 Maybridge1_000570 NC(=O)c1ccc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B21 compound treatment 1528870.0 50100.0 0.24 1583410.0 48200.0 0.21 1675000.0 42828.66666667 0.223236645232681 1482740.0 -274670.0 -1.32435176198663 -0.3213 -0.2325 2069674 Maybridge1_000571 Cc1ccc2cc(F)ccc2n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B22 compound treatment 1476680.0 -2140.0 -0.01 1470450.0 -64800.0 -0.29 1516490.0 -115681.33333333 -0.602967936647745 1486240.0 -271170.0 -1.30747612516079 -1.1041 -0.752 2069675 Maybridge1_000572 [O-][N+](=O)c1ccc(OC(=O)c2cccnc2Oc3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B23 mock treatment 1537530.0 58700.0 0.29 1519330.0 -15900.0 -0.07 1639110.0 6938.66666667 0.0361665396009321 1676600.0 -80810.0 -0.389634346256014 -0.0683 -0.1393 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 B24 mock treatment 1497460.0 18600.0 0.09 1601990.0 66800.0 0.3 1585540.0 -46631.33333333 -0.24305735448357 1666270.0 -91140.0 -0.439441582944848 -0.1476 -0.2502 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C01 compound treatment 1366670.0 -112000.0 -0.55 1419100.0 -116000.0 -0.52 1451600.0 -180571.33333333 -0.941195274470096 1828640.0 71230.0 0.343443317458432 -0.8308 -0.663 1663724 Maybridge1_000573 CCOC(=O)C1=C(CC(=O)Nc2ccc(OC)cc2)C(=O)N(C1C)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C02 compound treatment 1404000.0 -74800.0 -0.37 1336160.0 -199000.0 -0.88 1333600.0 -298571.33333333 -1.55624883993531 1699850.0 -57560.0 -0.277531901627227 -1.5414 -0.8344 1566478 Maybridge1_000574 CSc1cccc(NC(=S)N2CCCCC2CCN3CCOCC3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C03 compound treatment 1368220.0 -111000.0 -0.54 1460800.0 -74400.0 -0.33 1434240.0 -197931.33333333 -1.0316811210504 1789800.0 32390.0 0.156171964796836 -0.8734 -0.7154 1208608 Maybridge1_000575 Cc1cc(Cl)ccc1Nc2nnc(s2)c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C04 compound treatment 1348480.0 -130000.0 -0.64 1374080.0 -161000.0 -0.71 1400290.0 -231881.33333333 -1.20863932908043 1668980.0 -88430.0 -0.426375018431127 -1.4937 -0.9336 2069676 Maybridge1_000576 Cc1ccccc1C(=O)N(c2nc3ccccc3s2)c4cc(cc(c4)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C05 compound treatment 1480590.0 1770.0 0.01 1483310.0 -51900.0 -0.23 1417230.0 -214941.33333333 -1.12034265620772 1745200.0 -12210.0 -0.0588718644695698 -0.7004 -0.6115 2069677 Maybridge1_000577 Cc1cc(OCc2c(C)c(C)c(C)c(C)c2C)c3c(Cl)ccc(C)c3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C06 compound treatment 1505780.0 27000.0 0.13 1495390.0 -39800.0 -0.18 1361020.0 -271151.33333333 -1.41332707073992 1725320.0 -32090.0 -0.154725481640335 -0.8064 -0.5605 1323864 Maybridge1_000578 COc1ccc(CCNC(=O)c2c(Cl)cccc2Cl)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C07 compound treatment 816100.0 -663000.0 -3.24 713010.0 -822000.0 -3.65 268220.0 -1363951.33333333 -7.10934856514992 1004320.0 -753090.0 -3.63110666776317 -8.8149 -0.9421 1488891 Maybridge1_000579 CC(C)N(Cc1ccc(cc1)N(C)C)C(=O)c2c(C)onc2c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C08 compound treatment 1428080.0 -50700.0 -0.25 1417930.0 -117000.0 -0.52 1354600.0 -277571.33333333 -1.4467901545559 1446880.0 -310530.0 -1.49725471529365 -1.8563 -0.8592 1292706 Maybridge1_000580 COc1cc2CCNC(c3ccc(N)cc3)c2cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C09 compound treatment 1398950.0 -79900.0 -0.39 1483040.0 -52200.0 -0.23 1572180.0 -59991.33333333 -0.312693927658275 1563850.0 -193560.0 -0.933270932574113 -0.9341 -0.8617 2069678 Maybridge1_000581 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc(cc2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C10 compound treatment 1345160.0 -134000.0 -0.65 1413610.0 -122000.0 -0.54 1331090.0 -301081.33333333 -1.56933175899732 1326530.0 -430880.0 -2.07753554157643 -2.4201 -0.8838 2069679 Maybridge1_000582 COc1ccc(CCNc2ccc(cc2N)C(F)(F)F)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C11 compound treatment 1478900.0 80.9 0.0 1485780.0 -49500.0 -0.22 1456430.0 -175741.33333333 -0.916019776832834 1566970.0 -190440.0 -0.918227507746508 -1.0266 -0.7804 2069680 Maybridge1_000583 Cc1ccc(cc1[N+](=O)[O-])C2=N/C(=C\c3cccs3)/C(=O)O2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C12 compound treatment 1209570.0 -269000.0 -1.32 1345730.0 -190000.0 -0.84 1335610.0 -296561.33333333 -1.54577208004899 1258080.0 -499330.0 -2.40757478178463 -3.0556 -0.9373 2069681 Maybridge1_000584 Fc1ccc(cc1)c2cn3Cc4ccccc4Cc3n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C13 compound treatment 1206880.0 -272000.0 -1.33 1330680.0 -205000.0 -0.91 1362460.0 -269711.33333333 -1.4058213323139 1734610.0 -22800.0 -0.109932719894037 -1.8768 -0.8768 1396404 Maybridge1_000585 CC(=O)Nc1ccc(NC(=O)c2c(C)onc2c3c(Cl)cccc3Cl)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C14 compound treatment 1261390.0 -217000.0 -1.06 1144610.0 -391000.0 -1.73 1011150.0 -621021.33333333 -3.23696089234426 1571080.0 -186330.0 -0.898410688502452 -3.4658 -0.8827 2069682 Maybridge1_000586 CCC(C(=O)Nc1ccc(cc1)C(F)(F)F)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C15 compound treatment 1380130.0 -98700.0 -0.48 1380320.0 -155000.0 -0.69 1341970.0 -290201.33333333 -1.51262173533409 1388000.0 -369410.0 -1.78115114280948 -2.2318 -0.8988 2069683 Maybridge1_000587 Cc1ccc(cc1)S(=O)(=O)Nc2ccc(C)c(c2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C16 compound treatment 1550780.0 72000.0 0.35 1444330.0 -90900.0 -0.4 1551100.0 -81071.33333333 -0.422569598505789 1487040.0 -270370.0 -1.30361883674345 -0.8886 -0.604 2069684 Maybridge1_000588 FC(F)(F)c1cccc(NC(=S)N(CCc2ccccc2)CCc3ccccn3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C17 compound treatment 1284760.0 -194000.0 -0.95 1467520.0 -67700.0 -0.3 1614900.0 -17271.33333333 -0.0900236876864638 1516450.0 -240960.0 -1.16181527130119 -1.2509 -0.816 2069685 Maybridge1_000589 CCOC(=O)C1CCN(CC1)c2ccc(cc2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C18 compound treatment 1471950.0 -6870.0 -0.03 1496100.0 -39100.0 -0.17 1627870.0 -4301.33333333 -0.0224199186688048 1601450.0 -155960.0 -0.751978376959386 -0.4908 -0.6351 2069686 Maybridge1_000590 Cc1c(NNc2cc3c(c([N+](=O)[O-])c2C)C(C)(C)CC3(C)C)cc4c(c1[N+](=O)[O-])C(C)(C)CC4(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C19 compound treatment 1367080.0 -112000.0 -0.55 1443290.0 -91900.0 -0.41 1485030.0 -147141.33333333 -0.766947471982792 1481730.0 -275680.0 -1.32922158861351 -1.5253 -0.9083 1235622 Maybridge1_000591 CC(=O)Nc1ccc(C)c(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C20 compound treatment 1295700.0 -183000.0 -0.9 1301200.0 -234000.0 -1.04 1239470.0 -392701.33333333 -2.04688436635259 1412860.0 -344550.0 -1.66128590524081 -2.8211 -0.9494 2069687 Maybridge1_000592 [O-][N+](=O)c1ccc(/C=N/c2cc(ccc2N3CCOCC3)C(F)(F)F)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C21 compound treatment 1341370.0 -137000.0 -0.67 1421070.0 -114000.0 -0.51 1443410.0 -188761.33333333 -0.983884161768063 1530880.0 -226530.0 -1.09223943147352 -1.6275 -0.9607 2069688 Maybridge1_000593 Cc1ccc([N+](=O)[O-])c(c1)C(=O)N(CCc2ccccn2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C22 compound treatment 1263600.0 -215000.0 -1.05 1280180.0 -255000.0 -1.13 1337040.0 -295131.33333333 -1.53831846480649 1473340.0 -284070.0 -1.36967490089031 -2.5461 -0.9888 1931746 Maybridge1_000594 Cc1ccc(cc1)S(=O)(=O)N/N=C/c2ccc(cc2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C23 mock treatment 1548660.0 69800.0 0.34 1426690.0 -109000.0 -0.48 1731970.0 99798.66666667 0.520182421711943 1655130.0 -102280.0 -0.493154324156232 -0.0563 -0.0606 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 C24 mock treatment 1447700.0 -31100.0 -0.15 1571740.0 36500.0 0.16 1668730.0 36558.66666667 0.190555409169402 1616360.0 -141050.0 -0.680088164081312 -0.24 -0.3241 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D01 compound treatment 1176610.0 -302000.0 -1.48 1334970.0 -200000.0 -0.89 1471100.0 -161071.33333333 -0.839555066617795 1776280.0 18870.0 0.0909837905438806 -1.5578 -0.8111 1042344 Maybridge1_000595 [O-][N+](=O)c1ccccc1N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D02 compound treatment 1335000.0 -144000.0 -0.7 1320370.0 -215000.0 -0.95 1257130.0 -375041.33333333 -1.95483482426687 1892920.0 135510.0 0.653376441791269 -1.479 -0.6222 2069689 Maybridge1_000596 [O-][N+](=O)c1cc(Cl)c(cc1N2CCOCC2)N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D03 compound treatment 1391040.0 -87800.0 -0.43 1313770.0 -221000.0 -0.98 1281870.0 -350301.33333333 -1.82588206825323 1720710.0 -36700.0 -0.176953106145226 -1.7073 -0.8035 1508813 Maybridge1_000597 CN1C(NC(=O)c2cc(Cl)ccc12)C3CCC=CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D04 compound treatment 1293530.0 -185000.0 -0.91 1264970.0 -270000.0 -1.2 1204350.0 -427821.33333333 -2.22994098685377 1531200.0 -226210.0 -1.09069651610658 -2.7129 -0.9349 2069690 Maybridge1_000598 CC(C)(C)NNC(=S)Nc1cc(Cl)ccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D05 compound treatment 1368280.0 -111000.0 -0.54 1368490.0 -167000.0 -0.74 1287560.0 -344611.33333333 -1.79622397683376 1615280.0 -142130.0 -0.685295503444713 -1.8809 -0.8832 2069691 Maybridge1_000599 N#Cc1cnn(c1n2cccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D06 compound treatment 1175330.0 -303000.0 -1.49 1386030.0 -149000.0 -0.66 1402150.0 -230021.33333333 -1.19894441694683 1569880.0 -187530.0 -0.904196621128454 -2.125 -0.9601 1154273 Maybridge1_000600 Cc1ccc(NC(=O)c2c(F)cccc2Cl)c(c1)C(=O)Nc3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D07 compound treatment 1381490.0 -97300.0 -0.48 1244390.0 -291000.0 -1.29 1313070.0 -319101.33333333 -1.66325773568955 1825990.0 68580.0 0.330666049576011 -1.5493 -0.7097 2069692 Maybridge1_000601 COc1cc([N+](=O)[O-])c(OC)cc1SCC(=O)NNC(=S)Nc2cc(ccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D08 compound treatment 1113280.0 -366000.0 -1.79 1034650.0 -501000.0 -2.22 1071680.0 -560491.33333333 -2.92145926253401 1334140.0 -423270.0 -2.04084308550654 -4.4855 -0.9829 2069693 Maybridge1_000602 [O-][N+](=O)c1cc(ccc1N2CCCCC2)c3n[nH]c(=O)c4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D09 compound treatment 1372900.0 -106000.0 -0.52 1294800.0 -240000.0 -1.07 1345230.0 -286941.33333333 -1.49562957750852 1659310.0 -98100.0 -0.472999992175659 -1.7766 -0.9035 2069694 Maybridge1_000603 COc1cc([N+](=O)[O-])c(OC)cc1SCc2nnc(S)n2c3cccc(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D10 compound treatment 1531890.0 53100.0 0.26 1511400.0 -23800.0 -0.11 1323160.0 -309011.33333333 -1.61066544352392 1666240.0 -91170.0 -0.439586231260498 -0.9481 -0.56 2069695 Maybridge1_000604 COC(=O)C(C)SCC(=O)Nc1c(C)cccc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D11 compound treatment 1481340.0 2520.0 0.01 1543200.0 7970.0 0.04 1441370.0 -190801.33333333 -0.994517291204919 1642970.0 -114440.0 -0.551785108099719 -0.7493 -0.6585 2069696 Maybridge1_000605 Sc1nc2ccccc2c(=O)n1NC(=O)c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D12 compound treatment 1638240.0 159000.0 0.78 1485390.0 -49800.0 -0.22 1463360.0 -168811.33333333 -0.879898410657631 1807150.0 49740.0 0.239826907347781 -0.0405 -0.0332 2069697 Maybridge1_000606 [O-][N+](=O)c1ccc(cc1)c2nc(no2)c3cccc(c3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D13 compound treatment 1338680.0 -140000.0 -0.69 1398180.0 -137000.0 -0.61 1552730.0 -79441.33333333 -0.414073519593007 1678890.0 -78520.0 -0.378592858161394 -1.0431 -0.9708 2069698 Maybridge1_000607 Clc1ccc(cc1)c2noc(CCC(=O)NNS(=O)(=O)c3ccc(Cl)cc3)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D14 compound treatment 1512690.0 33900.0 0.17 1518240.0 -17000.0 -0.08 1541360.0 -90811.33333333 -0.473337579248425 1668020.0 -89390.0 -0.431003764531928 -0.407 -0.6115 2069699 Maybridge1_000608 CC1CCC(C)(C)CN(C1)c2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D15 compound treatment 1534720.0 55900.0 0.27 1425320.0 -110000.0 -0.49 1578100.0 -54071.33333333 -0.281837003017987 1580570.0 -176840.0 -0.85265360465182 -0.6742 -0.6374 2069700 Maybridge1_000609 N#Cc1cccc(c1)n2cccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D16 compound treatment 1516990.0 38200.0 0.19 1429930.0 -105000.0 -0.47 1481920.0 -150251.33333333 -0.783157782055646 1638400.0 -119010.0 -0.573819868183743 -0.8186 -0.7487 2069701 Maybridge1_000610 [O-][N+](=O)c1ccc(c(C#N)c1)n2cccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D17 compound treatment 1473560.0 -5260.0 -0.03 1494240.0 -41000.0 -0.18 1437700.0 -194471.33333333 -1.01364649955456 1816540.0 59130.0 0.285101830146246 -0.468 -0.4379 1031325 Maybridge1_000611 COc1ccccc1CCC(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D18 compound treatment 1517620.0 38800.0 0.19 1441680.0 -93600.0 -0.41 1662400.0 30228.66666667 0.15756143400504 1888840.0 131430.0 0.633704270862863 0.2831 0.3554 1622063 Maybridge1_000612 Clc1ccc(OC(=O)c2cccs2)c(Sc3cc(Cl)ccc3OC(=O)c4cccs4)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D19 compound treatment 1339550.0 -139000.0 -0.68 1448960.0 -86300.0 -0.38 1424680.0 -207491.33333333 -1.08151088448979 1524640.0 -232770.0 -1.12232628112873 -1.634 -0.9371 2069702 Maybridge1_000613 C/C(=N\NC1=NCCN1Cc2ccccc2)/c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D20 compound treatment 1284930.0 -194000.0 -0.95 1378720.0 -157000.0 -0.69 1342580.0 -289591.33333333 -1.50944222113973 1483200.0 -274210.0 -1.32213382114666 -2.2372 -0.962 1152323 Maybridge1_000614 Cc1cc(ccc1Cl)c2csc(N)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D21 compound treatment 1509610.0 30800.0 0.15 1457010.0 -78200.0 -0.35 1680120.0 47948.66666667 0.249923715191849 1455650.0 -301760.0 -1.45496919101862 -0.7006 -0.4597 1111385 Maybridge1_000615 CCOC(=O)CNC(=O)c1ccc(cc1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D22 compound treatment 1191760.0 -287000.0 -1.4 1454260.0 -81000.0 -0.36 1459610.0 -172561.33333333 -0.899444604475382 1402770.0 -354640.0 -1.70993595540444 -2.1866 -0.9052 1353468 Maybridge1_000616 COc1ccc(OC(=O)c2cccnc2Oc3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D23 mock treatment 1448330.0 -30500.0 -0.15 1566240.0 31000.0 0.14 1645560.0 13388.66666667 0.0697859929674625 1577350.0 -180060.0 -0.868179190531592 -0.405 -0.4529 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 D24 mock treatment 1408420.0 -70400.0 -0.34 1057360.0 -478000.0 -2.12 1740710.0 108538.66666667 0.56573808410318 1793880.0 36470.0 0.175844135725242 -0.8611 -0.3866 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E01 compound treatment 1442820.0 -36000.0 -0.18 1448480.0 -86800.0 -0.38 1459250.0 -172921.33333333 -0.901321039081886 1842310.0 84900.0 0.409354733289638 -0.5264 -0.489 1374907 Maybridge1_000617 CCOC(=O)C1=C(C)N(C(=O)C1CC(=O)Nc2ccc(cc2)C(=O)OCC)c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E02 compound treatment 1220330.0 -258000.0 -1.26 1282290.0 -253000.0 -1.12 1180050.0 -452121.33333333 -2.35660032279279 1706600.0 -50810.0 -0.244986030605966 -2.4941 -0.8569 2069703 Maybridge1_000618 Oc1c(Cl)cc(Cl)cc1/C=C/2\SC(=S)NC2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E03 compound treatment 1255200.0 -224000.0 -1.09 1147710.0 -388000.0 -1.72 1010340.0 -621831.33333333 -3.24118287020889 1094320.0 -663090.0 -3.19716172081302 -4.6256 -0.9274 2069704 Maybridge1_000619 Fc1ccc(Nc2nnc(s2)c3ccccc3Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E04 compound treatment 1433570.0 -45200.0 -0.22 1389040.0 -146000.0 -0.65 1422520.0 -209651.33333333 -1.09276949212881 1911240.0 153830.0 0.741708346548232 -0.6104 -0.4103 1921741 Maybridge1_000620 [O-][N+](=O)c1cc(ccc1N2CCCCC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E05 compound treatment 1386780.0 -92000.0 -0.45 1392170.0 -143000.0 -0.63 1268280.0 -363891.33333333 -1.89671747464876 1712730.0 -44680.0 -0.215429558108139 -1.5985 -0.7754 1147994 Maybridge1_000621 Cc1cc(OCc2c(C)c(C)c(C)c(C)c2C)c3cc(F)ccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E06 compound treatment 1221530.0 -257000.0 -1.26 1343860.0 -191000.0 -0.85 1217460.0 -414711.33333333 -2.16160749326691 1762950.0 5540.0 0.0267117222900423 -2.1213 -0.803 2069705 Maybridge1_000622 [O-][N+](=O)c1cc(ccc1N2CCCC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E07 compound treatment 1499410.0 20600.0 0.1 1245170.0 -290000.0 -1.29 1264970.0 -367201.33333333 -1.91397024839189 1731200.0 -26210.0 -0.126374411772926 -1.613 -0.6977 1265948 Maybridge1_000623 Clc1cccc(NC(=S)Nc2ccc(Cl)cc2C(=O)c3ccccc3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E08 compound treatment 1474690.0 -4130.0 -0.02 1457870.0 -77400.0 -0.34 1271640.0 -360531.33333333 -1.87920408498805 1572090.0 -185320.0 -0.893540861875567 -1.568 -0.7435 1407219 Maybridge1_000624 COc1cc2CCN(C(c3cccc(C)c3)c2cc1OC)C(=O)c4sc5ccccc5c4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E09 compound treatment 1531040.0 52200.0 0.26 1329160.0 -206000.0 -0.91 1387700.0 -244471.33333333 -1.27426241712456 1770720.0 13310.0 0.0641756360434049 -0.9342 -0.5875 1372571 Maybridge1_000625 Cc1cccc(NC(=S)Nc2ccc(C)c(NS(=O)(=O)C)c2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E10 compound treatment 1477920.0 -899.0 0.0 1216960.0 -318000.0 -1.41 1425470.0 -206701.33333333 -1.07739315299218 1485710.0 -271700.0 -1.31003157873727 -1.9016 -0.8618 2069706 Maybridge1_000626 [O-][N+](=O)c1cc(ccc1NCCc2ccccc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E11 compound treatment 1568590.0 89800.0 0.44 1513130.0 -22100.0 -0.1 1635520.0 3348.66666667 0.0174543167194058 1706400.0 -51010.0 -0.245950352710299 0.0564 0.1099 2069707 Maybridge1_000627 CN(C)c1ccc(/C=C/2\N=C(OC2=O)c3ccc(C)c(c3)[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E12 compound treatment 1573710.0 94900.0 0.46 1342720.0 -193000.0 -0.85 1610130.0 -22041.33333333 -0.114886446222642 1684480.0 -72930.0 -0.351640055345268 -0.428 -0.4116 1239898 Maybridge1_000628 COc1ccc(cc1)C(=O)CC2(O)C(=O)N(CN3CCCCC3)c4ccc(Br)cc42 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E13 compound treatment 1456360.0 -22500.0 -0.11 1391780.0 -143000.0 -0.64 1554360.0 -77811.33333333 -0.405577440680224 1683200.0 -74210.0 -0.357811716813004 -0.7547 -0.8961 2069708 Maybridge1_000629 Cc1onc(c1C(=O)Nc2ccc(C)c(c2)[N+](=O)[O-])c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E14 compound treatment 1162920.0 -316000.0 -1.55 882250.0 -653000.0 -2.9 921500.0 -710671.33333333 -3.70424523254728 1273920.0 -483490.0 -2.3312004711214 -5.2385 -0.9575 2069709 Maybridge1_000630 CCC(C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E15 compound treatment 1371840.0 -107000.0 -0.52 1387610.0 -148000.0 -0.65 1463230.0 -168941.33333333 -0.880576012043313 1597670.0 -159740.0 -0.770204064731292 -1.4145 -0.9828 2069710 Maybridge1_000631 Cc1onc(c1C(=O)N(c2nc3ccccc3s2)c4cccc(Cl)c4)c5c(Cl)cccc5Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E16 compound treatment 1348660.0 -130000.0 -0.64 1328320.0 -207000.0 -0.92 1218740.0 -413431.33333333 -2.15493572577712 1361280.0 -396130.0 -1.90998457594846 -2.8097 -0.9097 1278441 Maybridge1_000632 Cc1ccc(C)c(NC(=S)N(CCc2ccccc2)CCc3ccccn3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E17 compound treatment 959200.0 -520000.0 -2.54 872640.0 -663000.0 -2.94 944710.0 -687461.33333333 -3.58326732361128 1062170.0 -695240.0 -3.35217649908466 -6.2083 -0.9919 2069711 Maybridge1_000633 COc1cc(/C=C\2/SC(=S)NC2=O)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E18 compound treatment 1329570.0 -149000.0 -0.73 1155910.0 -379000.0 -1.68 1350820.0 -281351.33333333 -1.4664927179242 1393850.0 -363560.0 -1.75294472125772 -2.816 -0.961 2069712 Maybridge1_000634 [O-][N+](=O)c1ccc(s1)C2NC(=O)c3ccccc3N2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E19 compound treatment 1531360.0 52500.0 0.26 1483230.0 -52000.0 -0.23 1560270.0 -71901.33333333 -0.37477263922345 1569200.0 -188210.0 -0.907475316283188 -0.6279 -0.6033 1046617 Maybridge1_000635 CC(=O)Nc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E20 compound treatment 1150620.0 -328000.0 -1.61 1030400.0 -505000.0 -2.24 1328830.0 -303341.33333333 -1.58111159847148 1240480.0 -516930.0 -2.49243512696599 -3.9592 -0.9805 1935254 Maybridge1_000636 Cc1ccc(/C=N/NS(=O)(=O)c2ccc(C)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E21 compound treatment 1399520.0 -79300.0 -0.39 1299050.0 -236000.0 -1.05 1612480.0 -19691.33333333 -0.102637498096852 1246130.0 -511280.0 -2.46519302751856 -2.0016 -0.7391 2069713 Maybridge1_000637 CN(CCC#N)c1ccc(/C=N/CCC\N=C/c2ccc(cc2)N(C)CCC#N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E22 compound treatment 1290800.0 -188000.0 -0.92 1498370.0 -36900.0 -0.16 1687840.0 55668.66666667 0.290162812864658 1408170.0 -349240.0 -1.68389925858743 -1.2386 -0.636 1699144 Maybridge1_000638 CN(C)c1ccc(CC(C#N)c2ccc(N)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E23 mock treatment 1435140.0 -43700.0 -0.21 1588520.0 53300.0 0.24 1740650.0 108478.66666667 0.565425345002096 1596750.0 -160660.0 -0.774639946411227 -0.0933 -0.0923 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 E24 mock treatment 1350050.0 -129000.0 -0.63 1600010.0 64800.0 0.29 1684880.0 52708.66666667 0.274734350544514 1432190.0 -325220.0 -1.56808417385696 -0.8181 -0.4712 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F01 compound treatment 1462190.0 -16600.0 -0.08 1221200.0 -314000.0 -1.39 1370030.0 -262141.33333333 -1.3663640823938 1759930.0 2520.0 0.0121504585146041 -1.4141 -0.7242 1013657 Maybridge1_000639 [O-][N+](=O)c1ccccc1N2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F02 compound treatment 1511840.0 33000.0 0.16 1491200.0 -44000.0 -0.2 1612690.0 -19481.33333333 -0.101542911243058 1769210.0 11800.0 0.0568950041556858 -0.0392 -0.1404 1060533 Maybridge1_000640 COc1ccc(CCNC(=O)c2ccccc2)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F03 compound treatment 1207130.0 -272000.0 -1.33 1195090.0 -340000.0 -1.51 1164480.0 -467691.33333333 -2.43775611952409 1532960.0 -224450.0 -1.08221048158845 -3.179 -0.9517 1243303 Maybridge1_000641 Nc1ccccc1C(=O)Nc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F04 compound treatment 1503600.0 24800.0 0.12 1254690.0 -281000.0 -1.24 1287870.0 -344301.33333333 -1.79460815814483 1706880.0 -50530.0 -0.243635979659899 -1.5806 -0.7182 2069714 Maybridge1_000642 NC(=O)C(C1CCCC1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F05 compound treatment 1431400.0 -47400.0 -0.23 1457350.0 -77900.0 -0.35 1297470.0 -334701.33333333 -1.74456990197139 1595860.0 -161550.0 -0.778931179775512 -1.5505 -0.7929 2069715 Maybridge1_000643 N#CCc1nn(c(c1C#N)n2cccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F06 compound treatment 1485210.0 6390.0 0.03 1275960.0 -259000.0 -1.15 1543610.0 -88561.33333333 -0.461609862957775 1660390.0 -97020.0 -0.467792652812257 -1.024 -0.773 2069716 Maybridge1_000644 FC(F)(F)c1cc(Br)ccc1NC(=O)C(Cl)Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F07 compound treatment 1403100.0 -75700.0 -0.37 1186890.0 -348000.0 -1.54 1560100.0 -72071.33333333 -0.375658733343188 1375480.0 -381930.0 -1.84151770654077 -2.0663 -0.8396 2069717 Maybridge1_000645 FC(F)(F)c1cc(cc(c1)C(F)(F)F)n2c(S)nnc2CCc3nc(no3)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F08 compound treatment 1365090.0 -114000.0 -0.56 1410840.0 -124000.0 -0.55 1453480.0 -178691.33333333 -0.931396115969464 1563330.0 -194080.0 -0.935778170045381 -1.4877 -0.969 2069718 Maybridge1_000646 CN(C)c1ccc(cc1[N+](=O)[O-])c2n[nH]c(=O)c3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F09 compound treatment 1420480.0 -58300.0 -0.29 1444090.0 -91100.0 -0.4 1340270.0 -291901.33333333 -1.52148267653147 1494690.0 -262720.0 -1.26673351625269 -1.7389 -0.8521 1003095 Maybridge1_000647 Oc1nc(O)c2ccccc2n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F10 compound treatment 1450000.0 -28800.0 -0.14 1365150.0 -170000.0 -0.75 1513760.0 -118411.33333333 -0.617197565747068 1605080.0 -152330.0 -0.73447593076573 -1.1235 -0.9145 2069719 Maybridge1_000648 [O-][N+](=O)c1cccc(c1)c2ncon2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F11 compound treatment 634000.0 -845000.0 -4.13 550770.0 -984000.0 -4.37 494370.0 -1137801.33333333 -5.93058276998079 701120.0 -1056290.0 -5.09301897793299 -9.7617 -0.9898 2069720 Maybridge1_000649 N#C/C(=C\c1ccc[nH]1)/c2nn(c(c2C#N)n3cccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F12 compound treatment 1510450.0 31600.0 0.15 1251620.0 -284000.0 -1.26 1373660.0 -258511.33333333 -1.34744336677822 1937440.0 180030.0 0.868034542215942 -0.7912 -0.3872 1572812 Maybridge1_000650 Cc1cc(Cl)cc2c(O)c(cnc12)C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F13 compound treatment 1502330.0 23500.0 0.12 1490910.0 -44300.0 -0.2 1646970.0 14798.66666667 0.0771353618429367 1620010.0 -137400.0 -0.662489285677223 -0.3334 -0.4731 2069721 Maybridge1_000651 FC(F)(F)c1cc(cc(c1)S(=O)(=O)NNC(=O)CCc2nc(no2)c3ccc(Cl)cc3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F14 compound treatment 1380660.0 -98200.0 -0.48 1406430.0 -129000.0 -0.57 1451910.0 -180261.33333333 -0.939579455781162 1520430.0 -236980.0 -1.14262526142495 -1.5669 -0.9457 2069722 Maybridge1_000652 CC1(CC2CC(C)(C)C1)CN2c3ccc(cc3[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F15 compound treatment 1471440.0 -7380.0 -0.04 1370190.0 -165000.0 -0.73 1595280.0 -36891.33333333 -0.192289373740933 1658080.0 -99330.0 -0.478930573117311 -0.7196 -0.8029 2069723 Maybridge1_000653 Cn1c(S)nnc1c2ccc(o2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F16 compound treatment 1353030.0 -126000.0 -0.62 1555870.0 20600.0 0.09 1553780.0 -78391.33333333 -0.408600585324036 1586880.0 -170530.0 -0.822229242260093 -0.8774 -0.7911 2069724 Maybridge1_000654 N/C(=N\OC(=O)c1ccc(cc1)[N+](=O)[O-])/c2cccc(c2)n3cccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F17 compound treatment 1403110.0 -75700.0 -0.37 1538900.0 3670.0 0.02 1737370.0 105198.66666667 0.548328940809504 1872880.0 115470.0 0.556751366937037 0.3754 0.434 2069725 Maybridge1_000655 Cc1nc2c(Br)cc(Br)cc2c(=O)o1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F18 compound treatment 1458400.0 -20400.0 -0.1 1567200.0 32000.0 0.14 1584490.0 -47681.33333333 -0.24853028875254 1594760.0 -162650.0 -0.784234951349347 -0.4955 -0.5893 2069726 Maybridge1_000656 [O-][N+](=O)c1cc(ccc1Oc2ccc(C#N)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F19 compound treatment 1604760.0 126000.0 0.62 1525870.0 -9360.0 -0.04 1120830.0 -511341.33333333 -2.6652738155627 1477320.0 -280090.0 -1.35048489101407 -1.7205 -0.5639 2069727 Maybridge1_000657 Cc1cc(C)c(NC(=O)CSc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F20 compound treatment 1461030.0 -17800.0 -0.09 1293840.0 -241000.0 -1.07 1514400.0 -117771.33333333 -0.613861682002172 1439620.0 -317790.0 -1.53225960768096 -1.6518 -0.8388 2069728 Maybridge1_000658 COc1cc(/C=C(\C#N)/c2nn(c(c2C#N)n3cccc3)c4ccccc4)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F21 compound treatment 1451930.0 -26900.0 -0.13 1522720.0 -12500.0 -0.06 1615940.0 -16231.33333333 -0.0846028766010077 1770250.0 12840.0 0.0619094790982208 -0.1049 -0.592 2069729 Maybridge1_000659 CCOC(=O)CNC(=O)c1c(OC)cccc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F22 compound treatment 1598880.0 120000.0 0.59 1593600.0 58400.0 0.26 1655630.0 23458.66666667 0.122274038766061 1625530.0 -131880.0 -0.635873995597614 0.1664 0.1825 1547053 Maybridge1_000660 CCOC(=O)c1ccc(OC(=O)c2cccnc2Oc3ccccc3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F23 mock treatment 1549390.0 70600.0 0.35 1549200.0 14000.0 0.06 1690720.0 58548.66666667 0.30517428971669 1859520.0 102110.0 0.492334650367549 0.6024 0.8895 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 F24 mock treatment 1534780.0 56000.0 0.27 1603680.0 68400.0 0.3 1735620.0 103448.66666667 0.539207383694553 1905650.0 148240.0 0.714755543732107 0.9157 0.9303 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G01 compound treatment 1291460.0 -187000.0 -0.92 1195150.0 -340000.0 -1.51 1339380.0 -292791.33333333 -1.52612163986421 1632610.0 -124800.0 -0.601736993104202 -2.2764 -0.9447 2069730 Maybridge1_000661 Fc1ccc(NC(=S)NNC(=O)c2ccccc2Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G02 compound treatment 1364990.0 -114000.0 -0.56 1323070.0 -212000.0 -0.94 1334080.0 -298091.33333333 -1.55374692712663 1809720.0 52310.0 0.252218446388468 -1.3997 -0.7303 2069731 Maybridge1_000662 Fc1cccc(/N=C/c2ccc(Cl)c(Cl)c2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G03 compound treatment 1015070.0 -464000.0 -2.27 1116560.0 -419000.0 -1.86 868080.0 -764091.33333333 -3.98268727887907 1377790.0 -379620.0 -1.83037978623571 -4.9695 -0.9424 2069732 Maybridge1_000663 CCOC(=O)CCc1cc(/N=C/c2cc(Br)ccc2O)c(O)c(/N=C/c3cc(Br)ccc3O)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G04 compound treatment 1499940.0 21100.0 0.1 1426670.0 -109000.0 -0.48 1319860.0 -312311.33333333 -1.62786609408354 1790840.0 33430.0 0.161186439739371 -0.9224 -0.5399 2069733 Maybridge1_000664 [O-][N+](=O)c1cc(ccc1N2CCOCC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G05 compound treatment 1099200.0 -380000.0 -1.86 994630.0 -541000.0 -2.4 888000.0 -744171.33333333 -3.87885789731918 1336480.0 -420930.0 -2.02956051688583 -5.0817 -0.9542 2069734 Maybridge1_000665 Cc1cc(OC(=O)c2c(C)onc2c3c(Cl)cccc3Cl)n(n1)c4ccc(NC(=O)c5c(C)onc5c6c(Cl)cccc6Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G06 compound treatment 1329500.0 -149000.0 -0.73 1261450.0 -274000.0 -1.21 1205170.0 -427001.33333333 -2.22566688580562 1477990.0 -279420.0 -1.34725441196455 -2.7589 -0.9312 2069735 Maybridge1_000666 COc1cc2CCN=C(c3ccc(cc3)[N+](=O)[O-])c2cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G07 compound treatment 1376410.0 -102000.0 -0.5 1409120.0 -126000.0 -0.56 1277230.0 -354941.33333333 -1.85006722540373 1632530.0 -124880.0 -0.602122721945936 -1.7563 -0.8422 1681606 Maybridge1_000667 Cc1nc2cc(Cl)ccc2c(=O)n1c3cccnc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G08 compound treatment 1424480.0 -54300.0 -0.27 1325250.0 -210000.0 -0.93 1208170.0 -424001.33333333 -2.21002993075142 1679040.0 -78370.0 -0.377869616583144 -1.8925 -0.7749 1649904 Maybridge1_000668 Fc1ccc(NC(=O)c2ccncc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G09 compound treatment 1441230.0 -37600.0 -0.18 1460590.0 -74600.0 -0.33 1348160.0 -284011.33333333 -1.48035748473892 1720100.0 -37310.0 -0.179894288563444 -1.0876 -0.7069 1446338 Maybridge1_000669 Cc1ccc(NC(=S)Nc2cccc(Cl)c2)cc1NS(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G10 compound treatment 1383560.0 -95300.0 -0.47 1395580.0 -140000.0 -0.62 1057140.0 -575031.33333333 -2.99724637136337 1798260.0 40850.0 0.196962789810149 -1.9429 -0.6263 2069736 Maybridge1_000670 CC(Nc1ccc(cc1[N+](=O)[O-])C(F)(F)F)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G11 compound treatment 1458260.0 -20600.0 -0.1 1395910.0 -139000.0 -0.62 1100360.0 -531811.33333333 -2.77196997221586 1500700.0 -256710.0 -1.23775563701747 -2.3641 -0.7627 2069737 Maybridge1_000671 CC1(C)N/C(=N/c2ccccc2Cl)/SC1=C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G12 compound treatment 1303520.0 -175000.0 -0.86 1342740.0 -192000.0 -0.85 1120960.0 -511211.33333333 -2.66459621417702 1807360.0 49950.0 0.240839445557331 -2.0676 -0.7041 1649200 Maybridge1_000672 Cc1ccc(cc1)C(=O)CC2(O)C(=O)N(CN3CCCCC3)c4ccc(Br)cc42 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G13 compound treatment 1496890.0 18100.0 0.09 1351400.0 -184000.0 -0.82 1333650.0 -298521.33333333 -1.55598822401774 1817830.0 60420.0 0.291321707719198 -0.9957 -0.5585 1671135 Maybridge1_000673 CC(=O)Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G14 compound treatment 1152250.0 -327000.0 -1.6 1419610.0 -116000.0 -0.51 1270800.0 -361371.33333333 -1.88358243240323 1565480.0 -191930.0 -0.925411707423794 -2.4599 -0.9154 2069738 Maybridge1_000674 COc1cc(CN(C(=O)c2cccc(c2)[N+](=O)[O-])c3cccc(F)c3)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G15 compound treatment 1359480.0 -119000.0 -0.58 1320640.0 -215000.0 -0.95 1177400.0 -454771.33333333 -2.370412966424 1428170.0 -329240.0 -1.58746704815407 -2.7468 -0.8966 2069739 Maybridge1_000675 Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(N)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G16 compound treatment 1423310.0 -55500.0 -0.27 1481230.0 -54000.0 -0.24 1433760.0 -198411.33333333 -1.03418303385907 1601120.0 -156290.0 -0.753569508431536 -1.1494 -0.8643 2069740 Maybridge1_000676 Fc1cccc(Cl)c1/C=C/2\SC(=S)NC2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G17 compound treatment 1431360.0 -47500.0 -0.23 1532600.0 -2630.0 -0.01 1493990.0 -138181.33333333 -0.720245099554247 1833500.0 76090.0 0.36687634459374 -0.2986 -0.3551 1057803 Maybridge1_000677 Nc1nc2ccc(Cl)cc2c(c1C#N)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G18 compound treatment 1534080.0 55300.0 0.27 1604880.0 69600.0 0.31 1513850.0 -118321.33333333 -0.616728457095441 1995140.0 237730.0 1.1462414693162 0.5544 0.4062 2069741 Maybridge1_000678 Cc1ccc(cc1[N+](=O)[O-])N2C(=O)CC(SCC(=O)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G19 compound treatment 1438990.0 -39800.0 -0.19 1373040.0 -162000.0 -0.72 1447230.0 -184941.33333333 -0.963973105665715 1512010.0 -245400.0 -1.1832232220174 -1.5307 -0.9012 2069742 Maybridge1_000679 COc1cccc(/N=C/2\SC(=C)C(C)(C)N2C(=O)C(C3CCCC3)c4ccccc4)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G20 compound treatment 99890.0 -1380000.0 -6.75 97680.0 -1440000.0 -6.38 51880.0 -1580291.33333333 -8.23698151729181 112160.0 -1645250.0 -7.93275471077475 -14.6463 -0.9944 2069743 Maybridge1_000680 [O-][N+](=O)c1ccc(s1)C2Nc3ccccc3O2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G21 compound treatment 1206170.0 -273000.0 -1.33 1220020.0 -315000.0 -1.4 1279860.0 -352311.33333333 -1.83635882813955 1442460.0 -314950.0 -1.51856623379943 -3.0435 -0.992 2069744 Maybridge1_000681 COc1cc(CN2CCCN(Cc3cc(OC)c(OC)c(OC)c3)C2c4cc(Br)ccc4O)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G22 compound treatment 1304960.0 -174000.0 -0.85 1355290.0 -180000.0 -0.8 1475800.0 -156371.33333333 -0.815057170366214 1354130.0 -403280.0 -1.94445909117839 -2.2041 -0.9148 1014047 Maybridge1_000682 [O-][N+](=O)c1ccc(cc1)N2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G23 mock treatment 1439880.0 -38900.0 -0.19 1570910.0 35700.0 0.16 1603960.0 -28211.33333333 -0.147046450450781 1422460.0 -334950.0 -1.61499844423279 -0.8972 -0.5469 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 G24 mock treatment 1579960.0 101000.0 0.49 1508550.0 -26700.0 -0.12 1612360.0 -19811.33333333 -0.10326297629902 1782520.0 25110.0 0.121070640199091 0.1972 0.3699 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H01 compound treatment 1336380.0 -142000.0 -0.7 1482620.0 -52600.0 -0.23 1487480.0 -144691.33333333 -0.754177292021861 1982530.0 225120.0 1.08544096063796 -0.2995 -0.1981 2069745 Maybridge1_000683 Cc1onc(c1C(=O)SCC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H02 compound treatment 1379520.0 -99300.0 -0.49 1278240.0 -257000.0 -1.14 1399490.0 -232681.33333333 -1.21280918376155 1742250.0 -15160.0 -0.0730956155084912 -1.4558 -0.8389 2069746 Maybridge1_000684 COc1cc2CCN(Cc2cc1OC)c3c(cc(cc3[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H03 compound treatment 1473060.0 -5760.0 -0.03 1431050.0 -104000.0 -0.46 1334560.0 -297611.33333333 -1.55124501431796 1807680.0 50270.0 0.242382360924265 -0.8995 -0.5495 1364884 Maybridge1_000685 COc1ccc(CCNC(=O)c2ccccc2N)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H04 compound treatment 1454820.0 -24000.0 -0.12 1271490.0 -264000.0 -1.17 1301810.0 -330361.33333333 -1.72194844032631 1874680.0 117270.0 0.56543026587604 -1.2218 -0.5656 2069747 Maybridge1_000686 [O-][N+](=O)c1ccc(cc1)c2cn3nc(sc3n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H05 compound treatment 1181640.0 -297000.0 -1.45 1326040.0 -209000.0 -0.93 1107200.0 -524971.33333333 -2.73631771469228 1544260.0 -213150.0 -1.0277262826936 -3.073 -0.9054 2069748 Maybridge1_000687 OC(C(=O)NNC(=S)Nc1cc(Cl)ccc1Cl)(c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H06 compound treatment 1549770.0 71000.0 0.35 1442940.0 -92300.0 -0.41 1566170.0 -66001.33333333 -0.34401996095019 1927890.0 170480.0 0.821988161734009 0.2079 0.1999 2069749 Maybridge1_000688 [O-][N+](=O)c1cc(ccc1Oc2ccc(Cl)cc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H07 compound treatment 1443040.0 -35800.0 -0.18 1505600.0 -29600.0 -0.13 1385560.0 -246611.33333333 -1.28541677839656 1761540.0 4130.0 0.01991325145449 -0.786 -0.6027 2069750 Maybridge1_000689 Fc1ccccc1n2c(S)nnc2CCc3nc(no3)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H08 compound treatment 1138270.0 -341000.0 -1.67 1493930.0 -41300.0 -0.18 1473960.0 -158211.33333333 -0.824647836132791 1527600.0 -229810.0 -1.10805431398459 -1.8912 -0.8706 2069751 Maybridge1_000690 N/C(=N\O)/c1cccc(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H09 compound treatment 1430150.0 -48700.0 -0.24 1516110.0 -19100.0 -0.08 1266590.0 -365581.33333333 -1.90552629266262 1450940.0 -306470.0 -1.47767897657568 -1.8531 -0.7643 2069752 Maybridge1_000691 COc1cc(cc(OC)c1OC)C(=O)NNC(=O)CSc2cc(OC)c(cc2OC)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H10 compound treatment 925520.0 -553000.0 -2.71 917290.0 -618000.0 -2.74 1036510.0 -595661.33333333 -3.10477649895275 1134670.0 -622740.0 -3.00260973626371 -5.7777 -0.9983 2069753 Maybridge1_000692 N/C(=N\OC(=O)c1c(Cl)cccc1Cl)/c2cccc(c2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H11 compound treatment 1372110.0 -107000.0 -0.52 1238720.0 -297000.0 -1.31 1575640.0 -56531.33333333 -0.294659306162431 1879280.0 121870.0 0.587609674275714 -0.7721 -0.4949 2069754 Maybridge1_000693 [O-][N+](=O)c1cc(c(cc1N2CCCCC2)N3CCCCC3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H12 compound treatment 1501250.0 22400.0 0.11 1507920.0 -27300.0 -0.12 1531560.0 -100611.33333333 -0.524418299092146 1842850.0 85440.0 0.411958402971338 -0.0619 -0.0902 2069755 Maybridge1_000694 CN(NC(=O)C)c1ccc(cc1[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H13 compound treatment 1608720.0 130000.0 0.64 1485340.0 -49900.0 -0.22 1538930.0 -93241.33333333 -0.486003512842328 1753560.0 -3850.0 -0.0185632005084229 -0.0451 -0.0543 2069756 Maybridge1_000695 Clc1ccc(cc1)c2noc(CCC(=O)NNS(=O)(=O)c3cc(Cl)c(Cl)cc3Cl)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H14 compound treatment 1445800.0 -33000.0 -0.16 1531050.0 -4180.0 -0.02 1527920.0 -104251.33333333 -0.543391137891242 1761460.0 4050.0 0.0195275226127566 -0.352 -0.6202 2069757 Maybridge1_000696 [O-][N+](=O)c1cc(Cl)ccc1Sc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H15 compound treatment 1412760.0 -66100.0 -0.32 1521240.0 -14000.0 -0.06 1384480.0 -247691.33333333 -1.29104608221607 1810560.0 53150.0 0.256268599226669 -0.71 -0.5233 1295661 Maybridge1_000697 Cc1cccnc1N2C(=O)C3C4CC(C=C4)C3C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H16 compound treatment 1395420.0 -83400.0 -0.41 1463520.0 -71700.0 -0.32 1504540.0 -127631.33333333 -0.665255140946976 1552420.0 -204990.0 -0.988381940836782 -1.1899 -0.9161 2069758 Maybridge1_000698 CC(C)(C)c1ccc(OS(=O)(=O)c2ccc(Oc3c(Cl)cccc3[N+](=O)[O-])cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H17 compound treatment 1253980.0 -225000.0 -1.1 1499420.0 -35800.0 -0.16 1601200.0 -30971.33333333 -0.161432449100645 1738610.0 -18800.0 -0.0906462778073638 -0.7556 -0.6705 2069759 Maybridge1_000699 Cc1nc2c(Br)cc(Br)cc2c(=O)n1c3ccc(Cl)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H18 compound treatment 1305550.0 -173000.0 -0.85 1409060.0 -126000.0 -0.56 1372760.0 -259411.33333333 -1.35213445329448 1371370.0 -386040.0 -1.86133452578483 -2.3104 -0.9187 2069760 Maybridge1_000700 Nc1cc(ccc1Oc2ccc(C#N)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H19 compound treatment 1333280.0 -146000.0 -0.71 1232160.0 -303000.0 -1.34 1424450.0 -207721.33333333 -1.08270971771061 1359840.0 -397570.0 -1.91692769509966 -2.5279 -0.9447 2069761 Maybridge1_000701 [O-][N+](=O)c1ccc(cc1)/C(=C/c2c(F)cccc2Cl)/C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H20 compound treatment 1471520.0 -7300.0 -0.04 1274560.0 -261000.0 -1.16 1575100.0 -57071.33333333 -0.297473958072187 1805320.0 47910.0 0.231003360093128 -0.6291 -0.5172 2069762 Maybridge1_000702 Clc1ccc(/C=C(\C#N)/c2nn(c(c2C#N)n3cccc3)c4ccccc4)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H21 compound treatment 1469290.0 -9530.0 -0.05 1260320.0 -275000.0 -1.22 1663620.0 31448.66666667 0.163920462393748 1678800.0 -78610.0 -0.379026803108344 -0.7405 -0.5749 2069763 Maybridge1_000703 O=C1CCC(=O)N(N1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H22 compound treatment 1434420.0 -44400.0 -0.22 1485280.0 -50000.0 -0.22 1638610.0 6438.66666667 0.033560380425232 1740770.0 -16640.0 -0.0802315990805603 -0.2427 -0.7533 2069764 Maybridge1_000704 O=C(NNC(=O)c1cccnc1Oc2ccccc2)c3cccnc3Oc4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H23 mock treatment 1510880.0 32100.0 0.16 1587970.0 52700.0 0.23 1703070.0 70898.66666667 0.369546421356481 1860590.0 103180.0 0.497493773625734 0.6289 0.9239 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 H24 mock treatment 1487840.0 9020.0 0.04 1530880.0 -4350.0 -0.02 1678460.0 46288.66666667 0.241271266728525 1888800.0 131390.0 0.633511406441996 0.4498 0.6619 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I01 compound treatment 1308900.0 -170000.0 -0.83 1205140.0 -330000.0 -1.46 949800.0 -682371.33333333 -3.55673662320265 1657410.0 -100000.0 -0.482161052166829 -3.1671 -0.7989 2069765 Maybridge1_000705 COc1cccc(NC(=S)NNC(=O)c2ccccc2Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I02 compound treatment 1403740.0 -75100.0 -0.37 1195410.0 -340000.0 -1.51 755860.0 -876311.33333333 -4.56761364427319 1500000.0 -257410.0 -1.24113076438263 -3.8416 -0.7713 1339133 Maybridge1_000706 Cc1ccc(cc1)S(=O)(=O)N2CN3CCN(C3)C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I03 compound treatment 1158640.0 -320000.0 -1.57 956000.0 -579000.0 -2.57 604580.0 -1027591.33333333 -5.35613316447299 1386110.0 -371300.0 -1.79026398669543 -5.641 -0.8815 2069766 Maybridge1_000707 CCOC(=O)CCc1cc(/N=C/c2cc(Cl)cc(Cl)c2O)c(O)c(/N=C/c3cc(Cl)cc(Cl)c3O)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I04 compound treatment 1038880.0 -440000.0 -2.15 937040.0 -598000.0 -2.65 563160.0 -1069011.33333333 -5.57202739058798 1330670.0 -426740.0 -2.05757407401672 -6.2176 -0.9074 2069767 Maybridge1_000708 Oc1c(Cl)cc(Cl)cc1/C=N/c2cc(ccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I05 compound treatment 1361280.0 -118000.0 -0.58 1372770.0 -162000.0 -0.72 923870.0 -708301.33333333 -3.69189203805446 1573220.0 -184190.0 -0.888092441986082 -2.9378 -0.7518 2069768 Maybridge1_000709 CC(C)N(Cc1ccc(cc1)N(C)C)S(=O)(=O)c2ccccc2[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I06 compound treatment 1466730.0 -12100.0 -0.06 1271560.0 -264000.0 -1.17 1034180.0 -597991.33333333 -3.11692120071152 1787870.0 30460.0 0.146866256490016 -2.0993 -0.6299 1491155 Maybridge1_000710 COc1ccc(CCNC(=O)c2c(C)onc2c3ccccc3Cl)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I07 compound treatment 1049010.0 -430000.0 -2.1 1009920.0 -525000.0 -2.33 836080.0 -796091.33333333 -4.14948146612387 1371570.0 -385840.0 -1.86037020368049 -5.2214 -0.945 2069769 Maybridge1_000711 COc1cc(/C=N/N=C/c2cc(Br)ccc2O)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I08 compound treatment 1493470.0 14700.0 0.07 1436390.0 -98800.0 -0.44 1018890.0 -613281.33333333 -3.19661754830442 1773390.0 15980.0 0.0770493361362592 -1.7431 -0.54 2069770 Maybridge1_000712 C/C=C(\C)/c1nc2c(Br)cc(Br)cc2c(=O)o1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I09 compound treatment 1571750.0 92900.0 0.45 1522660.0 -12600.0 -0.06 1071490.0 -560681.33333333 -2.92244960302078 1804480.0 47070.0 0.226953207254926 -1.1483 -0.387 1127116 Maybridge1_000713 Cc1ccc(NC(=S)Nc2ccccc2Cl)cc1NS(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I10 compound treatment 1082510.0 -396000.0 -1.94 1064490.0 -471000.0 -2.09 747760.0 -884411.33333333 -4.60983342291953 1261600.0 -495810.0 -2.39060271274835 -5.5137 -0.9309 2069771 Maybridge1_000714 Nc1cc(ccc1NCCc2ccccn2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I11 compound treatment 1012770.0 -466000.0 -2.28 1085450.0 -450000.0 -1.99 541980.0 -1090191.33333333 -5.68242429327063 1233190.0 -524220.0 -2.52758466766895 -6.2426 -0.9024 2069772 Maybridge1_000715 Cc1cc(C)c(/N=C\2/NC(C)(C)C(=C)S2)cc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I12 compound treatment 1201950.0 -277000.0 -1.35 1198080.0 -337000.0 -1.5 750140.0 -882031.33333333 -4.59742810524319 1516000.0 -241410.0 -1.16398499603594 -4.3057 -0.8354 2069773 Maybridge1_000716 Oc1ccc(Br)cc1/C=N/c2cc(ccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I13 compound treatment 1337290.0 -142000.0 -0.69 1394360.0 -141000.0 -0.62 990340.0 -641831.33333333 -3.3454292372369 1440210.0 -317200.0 -1.52941485747318 -3.0961 -0.8159 2069774 Maybridge1_000717 COc1ccc(NC(=S)NC(=O)c2ccccc2)c(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I14 compound treatment 1067740.0 -411000.0 -2.01 971840.0 -563000.0 -2.5 644050.0 -988121.33333333 -5.15040295914323 1329440.0 -427970.0 -2.06350465495838 -5.862 -0.9147 1116212 Maybridge1_000718 C(Cc1ccncc1)c2c[nH]c3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I15 compound treatment 1331860.0 -147000.0 -0.72 1318490.0 -217000.0 -0.96 852340.0 -779831.33333333 -4.06472916973011 1699130.0 -58280.0 -0.281003461202828 -3.013 -0.7094 2069775 Maybridge1_000719 CCOC(=O)c1ccc(NC(=O)CSc2ccc(cc2[N+](=O)[O-])C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I16 compound treatment 1398600.0 -80200.0 -0.39 1340220.0 -195000.0 -0.86 993410.0 -638761.33333333 -3.3294274198981 1407880.0 -349530.0 -1.68529752563872 -3.1361 -0.8144 2069776 Maybridge1_000720 Fc1cccc(Cl)c1C=C2C(=O)NC(=S)NC2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I17 compound treatment 1337760.0 -141000.0 -0.69 1211770.0 -323000.0 -1.43 962940.0 -669231.33333333 -3.48824676006526 1479400.0 -278010.0 -1.340455941129 -3.4767 -0.8559 1949968 Maybridge1_000721 Fc1cccc(F)c1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I18 compound treatment 1250930.0 -228000.0 -1.12 1305620.0 -230000.0 -1.02 930360.0 -701811.33333333 -3.65806409195387 1339260.0 -418150.0 -2.01615643963559 -3.9038 -0.8789 2069777 Maybridge1_000722 CN1C(NC(=O)c2ccccc12)c3ccc(s3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I19 compound treatment 1318930.0 -160000.0 -0.78 1237640.0 -298000.0 -1.32 852690.0 -779481.33333333 -4.06290485830712 1220640.0 -536770.0 -2.58809587971589 -4.3766 -0.8657 2069778 Maybridge1_000723 Cc1ccc(NC(=O)c2ccccc2[N+](=O)[O-])c(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I20 compound treatment 540320.0 -938000.0 -4.59 623480.0 -912000.0 -4.04 356810.0 -1275361.33333333 -6.64758928239939 710400.0 -1047010.0 -5.04827443229191 -10.1659 -0.9822 2069779 Maybridge1_000724 [O-][N+](=O)c1csc(c1)C2Nc3ccccc3N2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I21 compound treatment 1046680.0 -432000.0 -2.11 1068800.0 -466000.0 -2.07 865210.0 -766961.33333333 -3.99764663254759 1114080.0 -643330.0 -3.10188669690486 -5.6413 -0.9625 2069780 Maybridge1_000725 COc1cc(cc(OC)c1OC)C2OC(=NN2C(=O)C)c3cc(C)ccc3[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I22 compound treatment 1319000.0 -160000.0 -0.78 1433320.0 -102000.0 -0.45 1262960.0 -369211.33333333 -1.92444700827821 1377030.0 -380380.0 -1.83404421023218 -2.4963 -0.8891 2069781 Maybridge1_000726 Fc1cccc(F)c1C(=O)Nc2nnc(s2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I23 mock treatment 1412050.0 -66800.0 -0.33 1659860.0 125000.0 0.55 1343040.0 -289131.33333333 -1.50704455469809 1758950.0 1540.0 0.00742528020336916 -0.6368 -0.3888 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 I24 mock treatment 1465820.0 -13000.0 -0.06 1574610.0 39400.0 0.17 1287930.0 -344241.33333333 -1.79429541904375 1942790.0 185380.0 0.893830158506867 -0.3947 -0.1961 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J01 compound treatment 1372320.0 -106000.0 -0.52 1309000.0 -226000.0 -1.0 1082440.0 -549731.33333333 -2.86537471707295 1667000.0 -90410.0 -0.43592180726403 -2.4129 -0.7756 2069782 Maybridge1_000727 FC(F)(F)c1cc(NC(=O)CSC(=O)c2c(Cl)cccc2Cl)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J02 compound treatment 1454510.0 -24300.0 -0.12 1268800.0 -266000.0 -1.18 1341340.0 -290831.33333333 -1.51590549589547 877630.0 -879780.0 -4.24195650475332 -3.5292 -0.7576 1367065 Maybridge1_000728 Cc1ccc2nc(NC(=O)C(C)(C)C)nc(O)c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J03 compound treatment 1442160.0 -36700.0 -0.18 1309770.0 -225000.0 -1.0 1641230.0 9058.66666667 0.0472166545059002 1471230.0 -286180.0 -1.37984849909103 -1.2559 -0.7327 2069783 Maybridge1_000729 Nc1nn(cc1C#N)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J04 compound treatment 1422350.0 -56500.0 -0.28 1354090.0 -181000.0 -0.8 1539970.0 -92201.33333333 -0.480582701756872 1753640.0 -3770.0 -0.0181774716666894 -0.7892 -0.8084 2069784 Maybridge1_000730 CC(C)(C)NNC(=O)c1ccccc1N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J05 compound treatment 1302050.0 -177000.0 -0.87 1113680.0 -422000.0 -1.87 1174640.0 -457531.33333333 -2.38479896507386 1469000.0 -288410.0 -1.39060069055435 -3.2549 -0.945 2069785 Maybridge1_000731 OC(C(=O)NNC(=S)Nc1ccc(F)cc1)(c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J06 compound treatment 1540800.0 62000.0 0.3 1513120.0 -22100.0 -0.1 1572570.0 -59601.33333333 -0.310661123501229 1745850.0 -11560.0 -0.0557378176304854 -0.0806 -0.1796 2069786 Maybridge1_000732 ClC(Cl)C(=O)Nc1cccc(C#N)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J07 compound treatment 1258560.0 -220000.0 -1.08 1488690.0 -46500.0 -0.21 1357060.0 -275111.33333333 -1.43396785141146 1555960.0 -201450.0 -0.971313439590076 -1.8448 -0.8997 2069787 Maybridge1_000733 COc1cc([N+](=O)[O-])c(OC)cc1SCC(=O)NNC(=O)c2cccc(C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J08 compound treatment 1473460.0 -5360.0 -0.03 1247040.0 -288000.0 -1.28 1406490.0 -225681.33333333 -1.17632295530175 1671580.0 -85830.0 -0.413838831074789 -1.4472 -0.8104 1550932 Maybridge1_000734 Clc1ccc(SCC(=O)Nc2cccc(C#N)c2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J09 compound treatment 1463320.0 -15500.0 -0.08 1462760.0 -72500.0 -0.32 1448420.0 -183751.33333333 -0.957770446827549 1890750.0 133340.0 0.642913546959249 -0.3561 -0.2967 2069788 Maybridge1_000735 COc1cc([N+](=O)[O-])c(OC)cc1SCC(=O)NNS(=O)(=O)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J10 compound treatment 1091110.0 -388000.0 -1.9 1051160.0 -484000.0 -2.15 986420.0 -645751.33333333 -3.36586152517438 1411430.0 -345980.0 -1.66818080828679 -4.539 -0.9608 2069789 Maybridge1_000736 N/C(=N\OC(=O)c1sc2ccccc2c1Cl)/c3cccc(c3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J11 compound treatment 1470280.0 -8540.0 -0.04 1466150.0 -69100.0 -0.31 1508110.0 -124061.33333333 -0.646647164432478 1786160.0 28750.0 0.138621302497963 -0.4281 -0.5864 2069790 Maybridge1_000737 CSC1=NC(C)(C)CCC(C)(C)N1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J12 compound treatment 1281730.0 -197000.0 -0.96 1409850.0 -125000.0 -0.56 1445470.0 -186701.33333333 -0.973146785964179 1488710.0 -268700.0 -1.29556674717227 -1.8946 -0.9637 2069791 Maybridge1_000738 CN(NC(=O)C)c1ccc(cc1NC(=O)c2sc3ccccc3c2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J13 compound treatment 1469840.0 -8980.0 -0.04 1537050.0 1820.0 0.01 1467360.0 -164811.33333333 -0.859049137252031 1873920.0 116510.0 0.561765841879572 -0.1666 -0.1621 2069792 Maybridge1_000739 Cc1ccc(cc1)S(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J14 compound treatment 1102580.0 -376000.0 -1.84 1165850.0 -369000.0 -1.64 1201140.0 -431031.33333333 -2.24667252876176 1442300.0 -315110.0 -1.51933769148289 -3.6226 -0.9886 1073582 Maybridge1_000740 [O-][N+](=O)c1cc(Cl)ccc1S(=O)(=O)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J15 compound treatment 1493600.0 14800.0 0.07 1558190.0 23000.0 0.1 1535130.0 -97041.33333333 -0.505810322577648 1678660.0 -78750.0 -0.379701828581378 -0.3557 -0.5517 1272417 Maybridge1_000741 Cc1cccc(n1)N2C(=O)C3C4CC(C=C4)C3C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J16 compound treatment 1248210.0 -231000.0 -1.13 1397770.0 -137000.0 -0.61 1283140.0 -349031.33333333 -1.81926242394695 1452180.0 -305230.0 -1.47170017952881 -2.5145 -0.9423 1535750 Maybridge1_000742 Nc1cccc(Cl)c1Oc2ccc(cc2)S(=O)(=O)Nc3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J17 compound treatment 935270.0 -544000.0 -2.66 1014640.0 -521000.0 -2.31 968080.0 -664091.33333333 -3.46145544373906 1162900.0 -594510.0 -2.86649567123701 -5.6482 -0.9892 2069793 Maybridge1_000743 C/C(=N\N=C1NCCN1)/c2ccc(Br)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J18 compound treatment 1363770.0 -115000.0 -0.56 1426900.0 -108000.0 -0.48 1570340.0 -61831.33333333 -0.322284593424851 1794800.0 37390.0 0.180280017405177 -0.5927 -0.7166 1727927 Maybridge1_000744 OC(=O)c1cccnc1Oc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J19 compound treatment 1249390.0 -229000.0 -1.12 1354100.0 -181000.0 -0.8 1330020.0 -302151.33333333 -1.57490893963332 1517920.0 -239490.0 -1.15472750383434 -2.3278 -0.9734 2069794 Maybridge1_000745 Cc1ccc(cc1)/C(=C/c2cccs2)/C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J20 compound treatment 1371850.0 -107000.0 -0.52 1459060.0 -76200.0 -0.34 1207270.0 -424901.33333333 -2.21472101726768 1483480.0 -273930.0 -1.32078377020059 -2.1984 -0.8287 2069795 Maybridge1_000746 [O-][N+](=O)c1cc(ccc1Sc2nnc(c3cccs3)n2c4cc(cc(c4)C(F)(F)F)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J21 compound treatment 1293800.0 -185000.0 -0.91 1366440.0 -169000.0 -0.75 1092910.0 -539261.33333333 -2.81080174393379 1469230.0 -288180.0 -1.38949172013437 -2.9271 -0.8742 2069796 Maybridge1_000747 CCN(CC)C(=S)Oc1c(Br)cc(Br)cc1Br 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J22 compound treatment 1527540.0 48700.0 0.24 1352560.0 -183000.0 -0.81 1475470.0 -156701.33333333 -0.816777235422176 1833440.0 76030.0 0.36658704796244 -0.5109 -0.4152 2069797 Maybridge1_000748 CSC1=NCN(CN1)C(C)(C)C#C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J23 mock treatment 1363590.0 -115000.0 -0.56 1578250.0 43000.0 0.19 1466300.0 -165871.33333333 -0.864574194704515 1536590.0 -220820.0 -1.06470803539479 -1.1512 -0.77 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 J24 mock treatment 1578790.0 100000.0 0.49 1435550.0 -99700.0 -0.44 1390560.0 -241611.33333333 -1.25935518663956 1956200.0 198790.0 0.958487955602439 -0.1269 -0.074 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K01 compound treatment 1282850.0 -196000.0 -0.96 1277010.0 -258000.0 -1.15 1381410.0 -250761.33333333 -1.30704789955487 1352760.0 -404650.0 -1.95106469759307 -2.6811 -0.9633 1285576 Maybridge1_000749 O=c1oc2ccccc2cc1C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K02 compound treatment 826090.0 -653000.0 -3.19 802850.0 -732000.0 -3.25 714240.0 -917931.33333333 -4.78455033405846 953120.0 -804290.0 -3.87797312647259 -7.5523 -0.9859 2069798 Maybridge1_000750 FC(F)(F)c1cc(NC(=O)C(C2CCCC2)c3ccccc3)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K03 compound treatment 1472320.0 -6500.0 -0.03 1436960.0 -98300.0 -0.44 1475930.0 -156241.33333333 -0.814379568980532 1720590.0 -36820.0 -0.177531699407826 -0.7298 -0.7754 1505255 Maybridge1_000751 CCN(Cc1cc(OC)c(OC)c(OC)c1)S(=O)(=O)c2cc(Cl)c(Cl)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K04 compound treatment 1311730.0 -167000.0 -0.82 1403210.0 -132000.0 -0.59 1455140.0 -177031.33333333 -0.92274366750614 1624810.0 -132600.0 -0.639345555173215 -1.4826 -0.9837 2069799 Maybridge1_000752 Nc1cc(ccc1N2CCCCC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K05 compound treatment 1555680.0 76900.0 0.38 1461250.0 -74000.0 -0.33 1536800.0 -95371.33333333 -0.49710575093081 1778680.0 21270.0 0.102555655795884 -0.1733 -0.2434 1366214 Maybridge1_000753 CC(C)N(Cc1ccc(cc1)N(C)C)S(=O)(=O)c2cc(Cl)c(Cl)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K06 compound treatment 1547750.0 68900.0 0.34 1336680.0 -199000.0 -0.88 1416320.0 -215851.33333333 -1.12508586590749 1884890.0 127480.0 0.614658909302273 -0.5268 -0.331 1452426 Maybridge1_000754 COc1ccc(CCNC(=O)c2c(C)onc2c3ccccc3)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K07 compound treatment 1552250.0 73400.0 0.36 1430880.0 -104000.0 -0.46 1518850.0 -113321.33333333 -0.590666865338441 1917650.0 160240.0 0.772614869992126 0.0392 0.0346 2069800 Maybridge1_000755 CCOC(=O)c1ccc(/N=C/c2cc(Cl)cc(Cl)c2O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K08 compound treatment 1512320.0 33500.0 0.16 1364810.0 -170000.0 -0.76 1486740.0 -145431.33333333 -0.758034407601898 1672760.0 -84650.0 -0.40814933065922 -0.879 -0.7596 1462342 Maybridge1_000756 Cc1onc(c1C(=O)Nc2ccc3OCOCc3c2)c4ccccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K09 compound treatment 1448250.0 -30600.0 -0.15 1448230.0 -87000.0 -0.39 1502880.0 -129291.33333333 -0.6739075894103 1812570.0 55160.0 0.265960036375223 -0.4717 -0.5653 1525441 Maybridge1_000757 COc1ccc(NC(=S)Nc2ccc(C)c(NS(=O)(=O)C)c2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K10 compound treatment 1511580.0 32800.0 0.16 1293770.0 -241000.0 -1.07 1536130.0 -96041.33333333 -0.500598004226248 1737780.0 -19630.0 -0.0946482145403485 -0.7529 -0.6292 1633514 Maybridge1_000758 CCOC(=O)c1cnc2c(Cl)cc(Br)cc2c1O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K11 compound treatment 1444260.0 -34600.0 -0.17 1309240.0 -226000.0 -1.0 1473710.0 -158461.33333333 -0.825950915720641 1739850.0 -17560.0 -0.0846674807604951 -1.041 -0.7932 2069801 Maybridge1_000759 Cc1cc2CSC(SCc2cc1C)c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K12 compound treatment 1398410.0 -80400.0 -0.39 1353860.0 -181000.0 -0.8 1479590.0 -152581.33333333 -0.795302483814408 1340680.0 -416730.0 -2.00930975269482 -2.0012 -0.8555 2069802 Maybridge1_000760 CCC(C(=O)NNC(=O)c1ccc(cc1)N(C)C)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K13 compound treatment 1231690.0 -247000.0 -1.21 1139790.0 -395000.0 -1.75 1069870.0 -562301.33333333 -2.93089355875005 1575470.0 -181940.0 -0.877243818312328 -3.3856 -0.9082 2069803 Maybridge1_000761 Clc1cccc(Nc2nc3ccccc3s2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K14 compound treatment 1487790.0 8970.0 0.04 1560760.0 25500.0 0.11 1566830.0 -65341.33333333 -0.340579830838265 1817280.0 59870.0 0.28866982193228 0.0526 0.1137 1035571 Maybridge1_000762 OC(=O)CCc1ccc2OCOc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K15 compound treatment 1521440.0 42600.0 0.21 1510240.0 -25000.0 -0.11 1571520.0 -60651.33333333 -0.316134057770199 1556730.0 -200680.0 -0.967600799488392 -0.593 -0.5675 1004900 Maybridge1_000763 CC(=O)Nc1ccccc1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K16 compound treatment 1540410.0 61600.0 0.3 1532160.0 -3070.0 -0.01 1454080.0 -178091.33333333 -0.928268724958624 1657300.0 -100110.0 -0.482691429324212 -0.5616 -0.5158 2069804 Maybridge1_000764 Cc1nc2ccc(Br)cc2c(=O)o1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K17 compound treatment 1530930.0 52100.0 0.26 1527710.0 -7520.0 -0.03 1650730.0 18558.66666667 0.0967336788442009 1870080.0 112670.0 0.543250857476366 0.4308 0.7077 2069805 Maybridge1_000765 Fc1cccc(F)c1C(=O)Nc2cccc(c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K18 compound treatment 568480.0 -910000.0 -4.45 781830.0 -753000.0 -3.34 486530.0 -1145641.33333333 -5.97144734585577 945490.0 -811920.0 -3.91476201475292 -8.841 -0.9764 2069806 Maybridge1_000766 [O-][N+](=O)c1cc(ccc1SCC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K19 compound treatment 465500.0 -1010000.0 -4.96 607790.0 -927000.0 -4.11 730650.0 -901521.33333333 -4.69901618991198 783780.0 -973630.0 -4.69446465221189 -9.2325 -0.9978 2069807 Maybridge1_000767 FC(F)(F)c1cc(Nc2nc3ccccc3s2)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K20 compound treatment 83890.0 -1390000.0 -6.83 81600.0 -1450000.0 -6.45 45530.0 -1586641.33333333 -8.2700797388232 87970.0 -1669440.0 -8.0493894692939 -14.796 -0.9945 2069808 Maybridge1_000768 [O-][N+](=O)c1ccc(s1)C2Nc3cc(ccc3O2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K21 compound treatment 1384890.0 -93900.0 -0.46 1092000.0 -443000.0 -1.97 1585320.0 -46851.33333333 -0.244204064520878 1518150.0 -239260.0 -1.15361853341435 -1.9115 -0.8177 2069809 Maybridge1_000769 Cc1ccc(cc1)S(=O)(=O)NNC(=S)NCc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K22 compound treatment 1336220.0 -143000.0 -0.7 1352500.0 -183000.0 -0.81 1465890.0 -166281.33333333 -0.866711245228589 1484100.0 -273310.0 -1.31779437167716 -1.8463 -0.9689 2069810 Maybridge1_000770 Cc1ccc(NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(N)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K23 mock treatment 1467360.0 -11500.0 -0.06 1600720.0 65500.0 0.29 1668850.0 36678.66666667 0.19118088737157 1545600.0 -211810.0 -1.02126532459456 -0.2979 -0.2757 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 K24 mock treatment 1578520.0 99700.0 0.49 1545470.0 10200.0 0.05 1660070.0 27898.66666667 0.145416732246278 1747400.0 -10010.0 -0.0482643213218995 0.3152 0.614 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L01 compound treatment 1510040.0 31200.0 0.15 1460530.0 -74700.0 -0.33 1698120.0 65948.66666667 0.343745445517051 1754880.0 -2530.0 -0.0121986746198208 0.0765 0.1526 1379387 Maybridge1_000771 Cc1nc2ccc(Br)cc2c(=O)n1c3ccccc3N4CCCCC4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L02 compound treatment 1562080.0 83300.0 0.41 1360610.0 -175000.0 -0.77 1697470.0 65298.66666667 0.34035743858864 1901180.0 143770.0 0.693202944700249 0.3333 0.2856 2069811 Maybridge1_000772 FC(F)(F)c1ccc(Cl)c(c1)C(=O)NNS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L03 compound treatment 1485120.0 6300.0 0.03 1211370.0 -324000.0 -1.44 1467810.0 -164361.33333333 -0.856703593993901 1878690.0 121280.0 0.58476492406793 -0.8387 -0.4733 2069812 Maybridge1_000773 CCOC(=O)CCc1nc(no1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L04 compound treatment 1368800.0 -110000.0 -0.54 1132970.0 -402000.0 -1.78 1344760.0 -287411.33333333 -1.49807936713368 1608710.0 -148700.0 -0.716973484572074 -2.2687 -0.9089 2069813 Maybridge1_000774 Fc1cccc(Cl)c1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L05 compound treatment 1467950.0 -10900.0 -0.05 1312910.0 -222000.0 -0.99 1432330.0 -199841.33333333 -1.04163664910158 1667200.0 -90210.0 -0.434957485159696 -1.2579 -0.8387 2069814 Maybridge1_000775 Clc1cccc(c1)n2ncc(C#N)c2n3cccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L06 compound treatment 1501090.0 22300.0 0.11 1362810.0 -172000.0 -0.76 1607840.0 -24331.33333333 -0.126822655247348 1977730.0 220320.0 1.06229723013396 0.1399 0.106 2069815 Maybridge1_000776 Clc1cccc(Cl)c1C(=O)Nc2ccc(C#N)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L07 compound treatment 1523400.0 44600.0 0.22 1332040.0 -203000.0 -0.9 1468610.0 -163561.33333333 -0.852533739312781 2051940.0 294530.0 1.42010894694696 -0.0577 -0.0304 2069816 Maybridge1_000777 COc1cc([N+](=O)[O-])c(OC)cc1SCC(=O)NNC(=O)c2cccc(c2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L08 compound treatment 1509860.0 31000.0 0.15 1311520.0 -224000.0 -0.99 1468440.0 -163731.33333333 -0.853419833432519 1861570.0 104160.0 0.502218951936969 -0.5957 -0.4225 1037133 Maybridge1_000778 [O-][N+](=O)c1cc(ccc1Oc2ccccc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L09 compound treatment 1458320.0 -20500.0 -0.1 1341310.0 -194000.0 -0.86 1559810.0 -72361.33333333 -0.377170305665094 1441870.0 -315540.0 -1.52141098400721 -1.4294 -0.7983 2069817 Maybridge1_000779 Oc1ccc(CCC(=O)NNC(=S)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L10 compound treatment 1607140.0 128000.0 0.63 1432870.0 -102000.0 -0.45 1504600.0 -127571.33333333 -0.664942401845892 1575090.0 -182320.0 -0.879076030310562 -0.685 -0.5084 2069818 Maybridge1_000780 N/C(=N\OC(=O)c1ccc(cc1)[N+](=O)[O-])/c2cccc(c2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L11 compound treatment 1500550.0 21700.0 0.11 1382440.0 -153000.0 -0.68 1434020.0 -198151.33333333 -1.03282783108771 1760050.0 2640.0 0.0127290517772043 -0.7957 -0.6417 2069819 Maybridge1_000781 CCOC(=O)C1CCN(CC1)c2ccc(cc2[N+](=O)[O-])C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L12 compound treatment 1302810.0 -176000.0 -0.86 1296730.0 -239000.0 -1.06 1473780.0 -158391.33333333 -0.825586053436043 1450500.0 -306910.0 -1.47980048520521 -2.1122 -0.971 2069820 Maybridge1_000782 Cc1cc(OC(=O)c2cccs2)c(Cl)c(C)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L13 compound treatment 1439400.0 -39400.0 -0.19 1403880.0 -131000.0 -0.58 1573940.0 -58231.33333333 -0.303520247359811 1894620.0 137210.0 0.661573179678105 -0.2087 -0.2192 2069821 Maybridge1_000783 Cc1ccc(cc1)S(=O)(=O)c2ccccc2C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L14 compound treatment 1427710.0 -51100.0 -0.25 1526240.0 -8990.0 -0.04 1645620.0 13448.66666667 0.0700987320685466 1652160.0 -105250.0 -0.507474507405587 -0.3637 -0.6364 2069822 Maybridge1_000784 OC(=O)c1ccccc1C(=O)c2ccc(Sc3ccc(Cl)cc3)c(c2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L15 compound treatment 1520320.0 41500.0 0.2 1507940.0 -27300.0 -0.12 1616880.0 -15291.33333333 -0.0797032973506916 1654720.0 -102690.0 -0.495131184470116 -0.2464 -0.4444 1632645 Maybridge1_000785 Cc1cc(C)nc(NS(=O)(=O)c2ccc(cc2)N3C(=O)C4C5CC(C=C5)C4C3=O)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L16 compound treatment 763840.0 -715000.0 -3.5 727370.0 -808000.0 -3.58 718760.0 -913411.33333333 -4.76099065511013 1192000.0 -565410.0 -2.72618680505647 -7.2843 -0.9806 2090 Maybridge1_000786 CCOC(=O)C(C#N)C1C(=C(N)Oc2ccc(Br)cc12)C(=O)OCC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L17 compound treatment 1438750.0 -40100.0 -0.2 1460900.0 -74300.0 -0.33 1456840.0 -175331.33333333 -0.91388272630876 1558560.0 -198850.0 -0.958777252233739 -1.1992 -0.8696 2069823 Maybridge1_000787 C/C(=N\N=C1NCCN1)/c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L18 compound treatment 1427870.0 -50900.0 -0.25 1505940.0 -29300.0 -0.13 1674490.0 42318.66666667 0.220578362873467 1835290.0 77880.0 0.375507027427526 0.1084 0.2092 2069824 Maybridge1_000788 Cc1ccc(cc1)S(=O)(=O)Oc2ccc(Cl)cc2Sc3cc(Cl)ccc3OS(=O)(=O)c4ccc(C)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L19 compound treatment 1540510.0 61700.0 0.3 1437130.0 -98100.0 -0.44 1631290.0 -881.333333329996 -0.00459378990701654 1795560.0 38150.0 0.183944441401645 0.0231 0.0412 2069825 Maybridge1_000789 COc1cc(CCC(=O)NNC(=S)Nc2ccc(F)cc2)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L20 compound treatment 1189070.0 -290000.0 -1.42 1374740.0 -160000.0 -0.71 1503940.0 -128231.33333333 -0.668382531957816 1469950.0 -287460.0 -1.38602016055877 -2.092 -0.9466 1250861 Maybridge1_000790 Fc1ccc(NC(=O)c2cccnc2Oc3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L21 compound treatment 1523710.0 44900.0 0.22 1223610.0 -312000.0 -1.38 1463080.0 -169091.33333333 -0.881357859796023 1981070.0 223660.0 1.07840140927633 -0.4826 -0.2445 2069826 Maybridge1_000791 CCN(CC)C(=S)Oc1c(C)cc(C)cc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L22 compound treatment 1510720.0 31900.0 0.16 1511390.0 -23800.0 -0.11 1550160.0 -82011.33333333 -0.427469177756105 1792710.0 35300.0 0.170202851414891 -0.1035 -0.208 1032648 Maybridge1_000792 CC(=O)COc1ccc(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L23 mock treatment 1405500.0 -73300.0 -0.36 1609720.0 74500.0 0.33 1641780.0 9608.66666667 0.0500834295991703 1599900.0 -157510.0 -0.759451873267972 -0.3689 -0.4081 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 L24 mock treatment 1618120.0 139000.0 0.68 1471380.0 -63900.0 -0.28 1639730.0 7558.66666667 0.0393981769788001 1937680.0 180270.0 0.869191728741142 0.6535 0.5728 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M01 compound treatment 1284640.0 -194000.0 -0.95 1269990.0 -265000.0 -1.18 1193490.0 -438681.33333333 -2.28654676414997 1576850.0 -180560.0 -0.870589995792426 -2.6418 -0.9185 1921024 Maybridge1_000793 FC(F)(F)c1cccc(NC(=O)c2ccc(Cl)cc2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M02 compound treatment 1561550.0 82700.0 0.4 1153030.0 -382000.0 -1.69 1387590.0 -244581.33333333 -1.27483577214322 1812360.0 54950.0 0.264947498165672 -1.15 -0.5287 2069827 Maybridge1_000794 [O-][N+](=O)c1ccc(cc1)C(=O)N(c2nc3ccccc3s2)c4cc(cc(c4)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M03 compound treatment 862020.0 -617000.0 -3.02 802480.0 -733000.0 -3.25 639380.0 -992791.33333333 -5.17474448584427 994770.0 -762640.0 -3.6771530482451 -7.5599 -0.9762 2069828 Maybridge1_000795 CN(C)c1ccc(/C=N/N=C(\C(=O)c2ccccc2)/c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M04 compound treatment 1472190.0 -6630.0 -0.03 1255360.0 -280000.0 -1.24 1351360.0 -280811.33333333 -1.46367806601444 1716830.0 -40580.0 -0.195660954969299 -1.4665 -0.7601 2069829 Maybridge1_000796 Oc1c(Cl)cc(Cl)cc1/C=N/c2cc(ccc2N3CCOCC3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M05 compound treatment 1240240.0 -239000.0 -1.17 1161860.0 -373000.0 -1.66 1042620.0 -589551.33333333 -3.0729292338257 1340330.0 -417080.0 -2.01099731637741 -3.9536 -0.9426 1365502 Maybridge1_000797 Cc1onc(c1C(=O)Oc2cc(C)nc3ccc(F)cc23)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M06 compound treatment 1558020.0 79200.0 0.39 1287620.0 -248000.0 -1.1 1564020.0 -68151.33333333 -0.3552264454057 1880160.0 122750.0 0.591852691534782 -0.237 -0.175 2069830 Maybridge1_000798 FC(F)(F)c1ccc(N2CCCCC2)c(NC(=O)c3sc4ccccc4c3Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M07 compound treatment 1553540.0 74700.0 0.37 1278580.0 -257000.0 -1.14 1416420.0 -215751.33333333 -1.12456463407235 1722300.0 -35110.0 -0.169286745415774 -1.0332 -0.6262 1668985 Maybridge1_000799 CCOC(=O)c1ccc(cc1)N2CC3CCCCN3C2c4ccc(Cl)c(Cl)c4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M08 compound treatment 1498010.0 19200.0 0.09 1340190.0 -195000.0 -0.86 1367050.0 -265121.33333333 -1.38189679108097 1773310.0 15900.0 0.0766636072945257 -1.0381 -0.635 2069831 Maybridge1_000800 [O-][N+](=O)c1cc(ccc1NCc2ccccc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M09 compound treatment 1530970.0 52200.0 0.26 1383430.0 -152000.0 -0.67 1622880.0 -9291.33333333 -0.0484293872422912 1743010.0 -14400.0 -0.0694311915120233 -0.2679 -0.3696 1516323 Maybridge1_000801 COc1ccccc1NC(=S)Nc2ccc(C)c(NS(=O)(=O)C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M10 compound treatment 1548130.0 69300.0 0.34 1397020.0 -138000.0 -0.61 1498210.0 -133961.33333333 -0.698249116111339 1687390.0 -70020.0 -0.337609168727213 -0.6548 -0.6266 2069832 Maybridge1_000802 FC(F)(F)c1cc(NC=C2C(=O)NC(=O)NC2=O)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M11 compound treatment 1551710.0 72900.0 0.36 1411960.0 -123000.0 -0.55 1600330.0 -31841.33333333 -0.165967166066363 1765220.0 7810.0 0.0376567781742293 -0.1592 -0.2359 2069833 Maybridge1_000803 Cc1cc2CSC(SCc2cc1C)c3ccc(Cl)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M12 compound treatment 1245010.0 -234000.0 -1.14 1290770.0 -244000.0 -1.08 1146460.0 -485711.33333333 -2.53168209621632 1578880.0 -178530.0 -0.860802126433439 -2.8104 -0.9054 2069834 Maybridge1_000804 Cc1c(Cl)cccc1NC(=S)Nc2cc3c(c([N+](=O)[O-])c2C)C(C)(C)CC3(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M13 compound treatment 1589440.0 111000.0 0.54 1519970.0 -15300.0 -0.07 1627620.0 -4551.33333333 -0.0237229982566548 1975220.0 217810.0 1.05019498772457 0.75 0.6337 2069835 Maybridge1_000805 Cc1ccc(cc1)S(=O)(=O)Nc2ccc(C)cc2[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M14 compound treatment 1555840.0 77000.0 0.38 1449210.0 -86000.0 -0.38 1612830.0 -19341.33333333 -0.100813186673862 1694190.0 -63220.0 -0.304822217179869 -0.2051 -0.3282 2069836 Maybridge1_000806 CCOC(=O)c1ccc(cc1)S(=O)(=O)NNC(=O)c2ccccc2N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M15 compound treatment 1279040.0 -200000.0 -0.98 1147680.0 -388000.0 -1.72 1175890.0 -456281.33333333 -2.37828356713461 1494290.0 -263120.0 -1.26866216046136 -3.1716 -0.9487 2069837 Maybridge1_000807 Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(/N=C/c3cc(Cl)cc(Cl)c3O)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M16 compound treatment 1560990.0 82200.0 0.4 1470430.0 -64800.0 -0.29 1609720.0 -22451.33333333 -0.117023496746716 1804350.0 46940.0 0.226326397887109 0.112 0.2014 1716824 Maybridge1_000808 COc1ccc(OC)c(CCC(=O)O)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M17 compound treatment 1504800.0 26000.0 0.13 1461480.0 -73800.0 -0.33 1517670.0 -114501.33333333 -0.596817400993093 1588890.0 -168520.0 -0.81253780511154 -0.8046 -0.7538 2069838 Maybridge1_000809 Cc1cc(/N=C/2\SC(=C)C(C)(C)N2C(=O)c3c(F)cccc3F)cc(C)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M18 compound treatment 1530450.0 51600.0 0.25 1471760.0 -63500.0 -0.28 1520590.0 -111581.33333333 -0.581597431407005 1731960.0 -25450.0 -0.122709987776458 -0.3666 -0.5203 2069839 Maybridge1_000810 COc1cc(/C=C(\C#N)/c2ccc(cc2)[N+](=O)[O-])cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M19 compound treatment 1298420.0 -180000.0 -0.88 1431530.0 -104000.0 -0.46 1429960.0 -202211.33333333 -1.05398984359439 1543150.0 -214260.0 -1.03307827037265 -1.7149 -0.9633 2069840 Maybridge1_000811 Cc1ccc(NC(=O)c2ccccc2/N=C/c3cc(Cl)cc(Cl)c3O)c(/N=C/c4cc(Cl)cc(Cl)c4O)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M20 compound treatment 1542400.0 63600.0 0.31 1533800.0 -1430.0 -0.01 1658840.0 26668.66666667 0.139005580674056 1723530.0 -33880.0 -0.163356164474122 0.1402 0.371 2069841 Maybridge1_000812 Cc1ccc(cc1)S(=O)(=O)N/N=C/c2ccc3OCOc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M21 compound treatment 1402080.0 -76700.0 -0.38 1464700.0 -70500.0 -0.31 1611380.0 -20791.33333333 -0.108371048283392 1619960.0 -137450.0 -0.662730366203306 -0.7297 -0.8786 2069842 Maybridge1_000813 COCCCNC(=S)NNS(=O)(=O)c1ccc(C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M22 compound treatment 1338170.0 -141000.0 -0.69 1512450.0 -22800.0 -0.1 1716000.0 83828.66666667 0.436941697640084 1545730.0 -211680.0 -1.02063851522674 -0.6865 -0.524 2069843 Maybridge1_000814 [O-][N+](=O)c1ccc(cc1)C2N(Cc3ccccc3)CCC4CCCCN24 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M23 mock treatment 1426430.0 -52400.0 -0.26 1484090.0 -51100.0 -0.23 1783530.0 151358.66666667 0.788929555910131 1602910.0 -154500.0 -0.74493882559775 -0.2196 -0.193 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 M24 mock treatment 1534850.0 56000.0 0.27 1358350.0 -177000.0 -0.78 1637700.0 5528.66666667 0.028817170725458 1947480.0 190070.0 0.916443511853491 0.2175 0.1758 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N01 compound treatment 1427260.0 -51600.0 -0.25 1315840.0 -219000.0 -0.97 1516100.0 -116071.33333333 -0.605000740804791 1809460.0 52050.0 0.250964827652834 -0.7896 -0.6582 2069844 Maybridge1_000815 COc1ccc(cc1)N2C(=O)CC(SCC(=O)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N02 compound treatment 1391430.0 -87400.0 -0.43 1320100.0 -215000.0 -0.95 1381720.0 -250451.33333333 -1.30543208086593 1660380.0 -97030.0 -0.467840868917474 -1.5775 -0.9083 1531991 Maybridge1_000816 COc1cc2CCN=C(c3ccccc3)c2cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N03 compound treatment 1590400.0 112000.0 0.55 1283160.0 -252000.0 -1.12 1574920.0 -57251.33333333 -0.298412175375439 1753840.0 -3570.0 -0.0172131495623558 -0.4437 -0.3468 1510864 Maybridge1_000817 CC(NC(=O)c1ccccc1N)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N04 compound treatment 1376770.0 -102000.0 -0.5 1329240.0 -206000.0 -0.91 1483720.0 -148451.33333333 -0.773775609023126 1668840.0 -88570.0 -0.42705004390416 -1.3069 -0.957 1610286 Maybridge1_000818 Cc1ccc2nc(oc(=O)c2c1)c3c(F)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N05 compound treatment 1543590.0 64800.0 0.32 1459870.0 -75400.0 -0.33 1544110.0 -88061.33333333 -0.459003703782075 1714940.0 -42470.0 -0.204773798855252 -0.3405 -0.4995 2069845 Maybridge1_000819 Cc1cccc(c1)C(=O)NNC(=O)CCc2nc(no2)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N06 compound treatment 1556880.0 78100.0 0.38 1306610.0 -229000.0 -1.01 1541150.0 -91021.33333333 -0.474432166102219 1907640.0 150230.0 0.724350548670227 -0.191 -0.1377 1684490 Maybridge1_000820 Fc1cccc(F)c1C(=O)Nc2cccc(C#N)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N07 compound treatment 1526830.0 48000.0 0.23 1429980.0 -105000.0 -0.47 1636500.0 4328.66666667 0.0225623887037779 1890400.0 132990.0 0.641225983276665 0.216 0.261 2069846 Maybridge1_000821 [O-][N+](=O)c1cc(ccc1NNc2ccc(cc2[N+](=O)[O-])C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N08 compound treatment 1386420.0 -92400.0 -0.45 1164450.0 -371000.0 -1.64 1379620.0 -252551.33333333 -1.31637794940387 1664000.0 -93410.0 -0.450386638829035 -1.9316 -0.8777 1471855 Maybridge1_000822 CN(C)c1ccc(cc1N)c2n[nH]c(=O)c3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N09 compound treatment 1589380.0 111000.0 0.54 1464020.0 -71200.0 -0.32 1740480.0 108308.66666667 0.564539250882358 1823250.0 65840.0 0.31745483674664 0.5536 0.6144 2069847 Maybridge1_000823 CNC(=S)NNC(=O)c1ccco1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N10 compound treatment 1370650.0 -108000.0 -0.53 1184370.0 -351000.0 -1.56 1382020.0 -250151.33333333 -1.30386838536051 1588330.0 -169080.0 -0.815237907003674 -2.1022 -0.934 1933421 Maybridge1_000824 N/C(=N\OC(=O)c1cccs1)/c2cccc(c2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N11 compound treatment 1168080.0 -311000.0 -1.52 1052170.0 -483000.0 -2.14 1243360.0 -388811.33333333 -2.02660844796565 1391200.0 -366210.0 -1.76572198914014 -3.7276 -0.9918 1430952 Maybridge1_000825 Clc1ccc(cc1)c2noc(CCC(=O)Nc3cccc(Cl)c3Cl)n2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N12 compound treatment 1526080.0 47300.0 0.23 1493850.0 -41400.0 -0.18 1645210.0 13038.66666667 0.0679616815444725 1905790.0 148380.0 0.71543056920514 0.4156 0.5349 2069848 Maybridge1_000826 Cc1cc(OC(=O)C(C2CCCC2)c3ccccc3)c(Cl)c(C)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N13 compound treatment 1296290.0 -183000.0 -0.89 1443130.0 -92100.0 -0.41 1600010.0 -32161.33333333 -0.167635107938811 1723780.0 -33630.0 -0.162150761843704 -0.8157 -0.8081 2069849 Maybridge1_000827 FC(F)(F)c1ccccc1S(=O)(=O)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N14 compound treatment 1445490.0 -33300.0 -0.16 1566920.0 31700.0 0.14 1585600.0 -46571.33333333 -0.242744615382486 1775490.0 18080.0 0.0871747182317626 -0.0891 -0.2651 2069850 Maybridge1_000828 Nc1ccccc1Sc2ccc(cc2[N+](=O)[O-])C(=O)c3ccccc3C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N15 compound treatment 1473600.0 -5220.0 -0.03 1461730.0 -73500.0 -0.33 1539290.0 -92881.33333333 -0.484127078235824 1684350.0 -73060.0 -0.352266864713085 -0.594 -0.8707 2069851 Maybridge1_000829 FC(F)(F)c1cc(cc(c1)S(=O)(=O)c2ccc(Br)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N16 compound treatment 1558050.0 79200.0 0.39 1436240.0 -99000.0 -0.44 1569440.0 -62731.33333333 -0.326975679941111 1685180.0 -72230.0 -0.3482649279801 -0.3633 -0.4806 2069852 Maybridge1_000830 C/C(=N\O)/c1ccc(Cl)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N17 compound treatment 1442080.0 -36700.0 -0.18 1463080.0 -72200.0 -0.32 1564810.0 -67361.33333333 -0.351108713908094 1629120.0 -128290.0 -0.618564413824824 -0.7347 -0.918 2069853 Maybridge1_000831 C/C(=N\NC1=NCCN1Cc2ccccc2)/c3ccc(F)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N18 compound treatment 1412920.0 -65900.0 -0.32 1538600.0 3370.0 0.01 1617570.0 -14601.33333333 -0.0761067976882256 1733550.0 -23860.0 -0.115043627047005 -0.2493 -0.7103 2069854 Maybridge1_000832 Cc1cc(ccc1Cl)C2=CSC3=NCCN23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N19 compound treatment 1463460.0 -15400.0 -0.08 1484220.0 -51000.0 -0.23 1724000.0 91828.66666667 0.478640244451285 1847530.0 90120.0 0.434523540212746 0.3059 0.444 1241971 Maybridge1_000833 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NCC(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N20 compound treatment 1214240.0 -265000.0 -1.29 1469920.0 -65300.0 -0.29 1401850.0 -230321.33333333 -1.20050811245225 1520760.0 -236650.0 -1.1410341299528 -1.9629 -0.925 2069855 Maybridge1_000834 FC(F)(F)c1ccc(N2CCOCC2)c(NC(=O)c3cccnc3Oc4ccccc4)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N21 compound treatment 1486170.0 7350.0 0.04 1445200.0 -90000.0 -0.4 1587390.0 -44781.33333333 -0.23341456553348 1661600.0 -95810.0 -0.461958504081039 -0.5293 -0.8085 1314785 Maybridge1_000835 O=C(Nc1ccccc1N2CCOCC2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N22 compound treatment 1288750.0 -190000.0 -0.93 1471710.0 -63500.0 -0.28 1614520.0 -17651.33333333 -0.0920043686599958 1526400.0 -231010.0 -1.11384024661059 -1.2088 -0.8162 2069856 Maybridge1_000836 COc1cc(/C=N/NS(=O)(=O)c2ccc(C)cc2)cc(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N23 mock treatment 1575210.0 96400.0 0.47 1558780.0 23500.0 0.1 1763470.0 131298.66666667 0.684370449781046 1994720.0 237310.0 1.1442163928971 1.2023 0.8479 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 N24 mock treatment 1481720.0 2900.0 0.01 1535070.0 -163.0 0.0 1716880.0 84708.66666667 0.441528537789316 1952730.0 195320.0 0.94175696709225 0.6984 0.6714 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O01 compound treatment 1451680.0 -27100.0 -0.13 1418010.0 -117000.0 -0.52 1376450.0 -255721.33333333 -1.33290099857781 1673440.0 -83970.0 -0.404870635504486 -1.1952 -0.8007 1345387 Maybridge1_000837 OC(=O)c1cc2cc(Br)ccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O02 compound treatment 1471230.0 -7590.0 -0.04 1359490.0 -176000.0 -0.78 1374010.0 -258161.33333333 -1.34561905535523 1780670.0 23260.0 0.112150660734004 -1.025 -0.6573 2069857 Maybridge1_000838 COc1cc(cc(OC)c1OC)C2NC(=O)c3cc(ccc3N2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O03 compound treatment 1474100.0 -4720.0 -0.02 1228900.0 -306000.0 -1.36 1372870.0 -259301.33333333 -1.35156109827582 1740730.0 -16680.0 -0.080424463501427 -1.4068 -0.7334 2069858 Maybridge1_000839 O=C(/C(=N\N=C\c1cccs1)/c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O04 compound treatment 1592200.0 113000.0 0.55 1357120.0 -178000.0 -0.79 1463290.0 -168881.33333333 -0.880263272942229 1719310.0 -38100.0 -0.183703360875562 -0.6495 -0.4923 1315297 Maybridge1_000840 COc1ccc(CCNC(=O)c2ccccc2Cl)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O05 compound treatment 1084610.0 -394000.0 -1.93 1022040.0 -513000.0 -2.28 904450.0 -727721.33333333 -3.79311526043865 1154150.0 -603260.0 -2.90868476330161 -5.4534 -0.9678 2069859 Maybridge1_000841 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc3OCOCc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O06 compound treatment 1249070.0 -230000.0 -1.12 1019110.0 -516000.0 -2.29 1053280.0 -578891.33333333 -3.01736592019977 1469490.0 -287920.0 -1.38823810139873 -3.9094 -0.9336 2069860 Maybridge1_000842 FC(F)(F)c1ccc(N2CCCC2)c(NC=C(C#N)C#N)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O07 compound treatment 1602940.0 124000.0 0.61 1396770.0 -138000.0 -0.61 1210250.0 -421921.33333333 -2.1991883085805 1727490.0 -29920.0 -0.144262586808315 -1.1751 -0.4964 1573890 Maybridge1_000843 CCOC(=O)c1ccc(cc1)N2CC3CCCCN3C2c4cccc(OC)c4O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O08 compound treatment 1307860.0 -171000.0 -0.84 1328960.0 -206000.0 -0.91 1013840.0 -618331.33333333 -3.22293975597899 1437870.0 -319540.0 -1.54069742609388 -3.2575 -0.8615 1949137 Maybridge1_000844 CCOC(=O)C(=CNc1ccccc1F)C(=O)OCC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O09 compound treatment 1461310.0 -17500.0 -0.09 1543170.0 7940.0 0.04 1114570.0 -517601.33333333 -2.69790292844246 1689360.0 -68050.0 -0.328110595999527 -1.5382 -0.5657 1130032 Maybridge1_000845 Cc1c(Cl)cccc1NC(=S)Nc2ccc(Cl)cc2C(=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O10 compound treatment 816320.0 -662000.0 -3.24 811520.0 -724000.0 -3.21 448640.0 -1183531.33333333 -6.16894208819032 1014430.0 -742980.0 -3.5823601853891 -8.1013 -0.9567 2069861 Maybridge1_000846 FC(F)(F)c1cc(NC=C(C#N)C#N)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O11 compound treatment 1448640.0 -30200.0 -0.15 1217290.0 -318000.0 -1.41 993040.0 -639131.33333333 -3.33135597768812 1592690.0 -164720.0 -0.7942156851292 -2.8416 -0.7666 2069862 Maybridge1_000847 CN(C)c1ccc(cc1)C2SCc3cc(C)c(C)cc3CS2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O12 compound treatment 1406570.0 -72200.0 -0.35 1335200.0 -200000.0 -0.89 1259250.0 -372921.33333333 -1.9437847093619 1658080.0 -99330.0 -0.478930573117311 -1.8317 -0.8258 2069863 Maybridge1_000848 Clc1ccc(cc1)C2CN3C(=N2)C=Cc4ccccc34 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O13 compound treatment 1184520.0 -294000.0 -1.44 1042900.0 -492000.0 -2.18 734170.0 -898001.33333333 -4.68066882931505 1441620.0 -315790.0 -1.52261638663763 -4.9134 -0.8815 2069864 Maybridge1_000849 CC1(C)N/C(=N\c2cccc(c2)C(F)(F)F)/SC1=C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O14 compound treatment 1572850.0 94000.0 0.46 1501050.0 -34200.0 -0.15 1157650.0 -474521.33333333 -2.47335625386415 1764520.0 7110.0 0.0342816508090615 -1.0653 -0.4226 1186960 Maybridge1_000850 Cc1ccc(cc1)S(=O)(=O)NN2C(Nc3ccccc3C2=O)c4cc(Cl)cc(Cl)c4O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O15 compound treatment 1508450.0 29600.0 0.14 1550800.0 15600.0 0.07 1196890.0 -435281.33333333 -2.26882488175521 1771850.0 14440.0 0.06962405593289 -0.9926 -0.4362 1932406 Maybridge1_000851 FC(F)(F)c1ccccc1NC(=O)c2cc3ccccc3oc2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O16 compound treatment 1268280.0 -211000.0 -1.03 1403910.0 -131000.0 -0.58 1229990.0 -402181.33333333 -2.09629714432387 1855810.0 98400.0 0.474446475332159 -1.6172 -0.6591 2069865 Maybridge1_000852 [O-][N+](=O)c1ccc(C=C2C(=O)NC(=O)NC2=O)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O17 compound treatment 1566560.0 87700.0 0.43 1531400.0 -3830.0 -0.02 1306350.0 -325821.33333333 -1.69828451501096 1773510.0 16100.0 0.0776279293988594 -0.6042 -0.3445 1041620 Maybridge1_000853 OC(=O)C(C1CCCC1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O18 compound treatment 1498930.0 20100.0 0.1 1494560.0 -40700.0 -0.18 1382560.0 -249611.33333333 -1.30105373345076 1735360.0 -22050.0 -0.106316512002786 -0.7447 -0.5635 2069866 Maybridge1_000854 CN(C)c1ccc(/C=C(\C#N)/c2ccc(cc2)[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O19 compound treatment 171530.0 -1310000.0 -6.4 176680.0 -1360000.0 -6.02 152340.0 -1479831.33333333 -7.71335201571016 338910.0 -1418500.0 -6.83945452498646 -13.4874 -0.9957 2069867 Maybridge1_000855 FC(F)(F)c1cc(NCCC2CCCCN2)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O20 compound treatment 1306000.0 -173000.0 -0.85 1326670.0 -209000.0 -0.92 1173440.0 -458731.33333333 -2.39105374709554 1551750.0 -205660.0 -0.9916124198863 -2.5766 -0.8959 2069868 Maybridge1_000856 Cc1ccc(cc1)S(=O)(=O)N/N=C/c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O21 compound treatment 1500320.0 21500.0 0.11 1519310.0 -15900.0 -0.07 1423270.0 -208901.33333333 -1.08886025336526 1850680.0 93270.0 0.449711613356001 -0.3023 -0.2551 2069869 Maybridge1_000857 FC(F)(F)c1cc(NC(=S)N2CCCCC2CCN3CCOCC3)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O22 compound treatment 1511630.0 32800.0 0.16 1593210.0 58000.0 0.26 1577170.0 -55001.33333333 -0.286684459084789 1878810.0 121400.0 0.58534351733053 0.3582 0.4983 2069870 Maybridge1_000858 CC(=O)Nc1ccc(Br)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O23 mock treatment 1335160.0 -144000.0 -0.7 1585970.0 50700.0 0.23 1595140.0 -37031.33333333 -0.193019098310129 1663380.0 -94030.0 -0.453376037352469 -0.5622 -0.6335 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 O24 mock treatment 1558490.0 79700.0 0.39 1586880.0 51600.0 0.23 1492320.0 -139851.33333333 -0.728949671201085 1870260.0 112850.0 0.544118747370266 0.217 0.2137 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P01 compound treatment 1401980.0 -76800.0 -0.38 1323960.0 -211000.0 -0.94 1467040.0 -165131.33333333 -0.860717079124479 1663710.0 -93700.0 -0.451784905880318 -1.3127 -0.9367 2069871 Maybridge1_000859 CCOC(=O)C(=CNNS(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)OCC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P02 compound treatment 1432320.0 -46500.0 -0.23 1452650.0 -82600.0 -0.37 1560450.0 -71721.33333333 -0.373834421920198 1765760.0 8350.0 0.0402604478559302 -0.4637 -0.8105 1214041 Maybridge1_000860 Cc1onc(c1C(=O)Nc2cccc3cccnc23)c4ccccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P03 compound treatment 1520500.0 41700.0 0.2 1473510.0 -61700.0 -0.27 1509680.0 -122491.33333333 -0.63846382462078 1679120.0 -78290.0 -0.37748388774141 -0.5429 -0.6649 809283 Maybridge1_000861 NC(=O)c1cnn(c1N)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P04 compound treatment 1495420.0 16600.0 0.08 1494090.0 -41100.0 -0.18 1515010.0 -117161.33333333 -0.610682167807817 1733550.0 -23860.0 -0.115043627047005 -0.4135 -0.6335 2069872 Maybridge1_000862 ClC(Cl)(Cl)C(=O)Nc1cccc2cccnc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P05 compound treatment 1538000.0 59200.0 0.29 1553120.0 17900.0 0.08 1537030.0 -95141.33333333 -0.495906917709988 1758430.0 1020.0 0.00491804273210165 -0.061 -0.1053 2069873 Maybridge1_000863 OC(c1nnc(S)n1c2ccc(F)cc2)(c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P06 compound treatment 1518750.0 39900.0 0.2 1399400.0 -136000.0 -0.6 1468970.0 -163201.33333333 -0.850657304706277 1689440.0 -67970.0 -0.327724867157793 -0.7927 -0.7141 2069874 Maybridge1_000864 Cc1onc(c1C(=O)Nc2cccc(C#N)c2)c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P07 compound treatment 1413180.0 -65600.0 -0.32 1221330.0 -314000.0 -1.39 1352250.0 -279921.33333333 -1.45903910268169 1479090.0 -278320.0 -1.34195064039072 -2.2571 -0.9237 2069875 Maybridge1_000865 CC(=O)c1c(O)nc2ccc(Cl)cc2c1c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P08 compound treatment 1537280.0 58500.0 0.29 1441540.0 -93700.0 -0.42 1531270.0 -100901.33333333 -0.525929871414052 1647570.0 -109840.0 -0.529605699700045 -0.5925 -0.6577 2069876 Maybridge1_000866 Cc1cccc(C)c1NC(=O)CSc2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P09 compound treatment 1464640.0 -14200.0 -0.07 1327150.0 -208000.0 -0.92 1576670.0 -55501.33333333 -0.289290618260489 1715750.0 -41660.0 -0.200868294332701 -0.7412 -0.7485 2069877 Maybridge1_000867 COc1cc([N+](=O)[O-])c(OC)cc1SCc2nnc(o2)c3ccccc3C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P10 compound treatment 1367520.0 -111000.0 -0.54 1439310.0 -95900.0 -0.43 1311740.0 -320431.33333333 -1.67019011909691 1727000.0 -30410.0 -0.146625175963933 -1.3934 -0.7684 2069878 Maybridge1_000868 [O-][N+](=O)c1ccc(N2CCCCC2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P11 compound treatment 1514050.0 35200.0 0.17 1491750.0 -43500.0 -0.19 1566040.0 -66131.33333333 -0.344697562335872 1742690.0 -14720.0 -0.0709741068789572 -0.2181 -0.4993 2069879 Maybridge1_000869 CCOC(=O)C1CCN(CC1)c2ccc(cc2N)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P12 compound treatment 1523050.0 44200.0 0.22 1385200.0 -150000.0 -0.67 1485550.0 -146621.33333333 -0.764237066440064 1583460.0 -173950.0 -0.838719150244198 -1.0259 -0.7696 2069880 Maybridge1_000870 CN(NC(=O)c1ccncc1)c2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P13 compound treatment 1534050.0 55200.0 0.27 1455840.0 -79400.0 -0.35 1503630.0 -128541.33333333 -0.66999835064675 1642130.0 -115280.0 -0.55583526093792 -0.6538 -0.6691 2069881 Maybridge1_000871 FC(F)(F)c1ccccc1S(=O)(=O)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P14 compound treatment 1658280.0 179000.0 0.88 1596980.0 61700.0 0.27 1587170.0 -45001.33333333 -0.234561275570788 1816640.0 59230.0 0.285583991198413 0.6015 0.6068 2069882 Maybridge1_000872 Clc1ccc(SC(C(=O)c2ccc(Cl)cc2)c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P15 compound treatment 1461850.0 -17000.0 -0.08 1533630.0 -1600.0 -0.01 1452250.0 -179921.33333333 -0.937807267541686 1710880.0 -46530.0 -0.224349537573225 -0.6262 -0.6469 2069883 Maybridge1_000873 Fc1ccccc1NC(=O)CSc2cc(cc(c2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P16 compound treatment 1572320.0 93500.0 0.46 1527550.0 -7680.0 -0.03 1519710.0 -112461.33333333 -0.586184271556237 1864550.0 107140.0 0.51658735129154 0.1769 0.1953 2069884 Maybridge1_000874 COc1ccc(NC(=S)NCCSc2ccc(Cl)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P17 compound treatment 1376870.0 -102000.0 -0.5 1455850.0 -79400.0 -0.35 1413410.0 -218761.33333333 -1.14025371231007 1690480.0 -66930.0 -0.322710392215258 -1.1569 -0.8679 2069885 Maybridge1_000875 C/C(=N\NC1=NCCN1Cc2ccccc2)/c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P18 compound treatment 1178840.0 -300000.0 -1.47 1122480.0 -413000.0 -1.83 1027950.0 -604221.33333333 -3.14939394404074 1407720.0 -349690.0 -1.68606898332218 -4.0669 -0.9516 2069886 Maybridge1_000876 N/C(=N\O)/c1ccc(OCc2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P19 compound treatment 1520590.0 41800.0 0.2 1421730.0 -114000.0 -0.5 1471940.0 -160231.33333333 -0.835176719202619 1773500.0 16090.0 0.0775797132936427 -0.5283 -0.5286 2069887 Maybridge1_000877 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NNC(=O)CCc2cc(OC)c(OC)c(OC)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P20 compound treatment 1302840.0 -176000.0 -0.86 1320400.0 -215000.0 -0.95 1419640.0 -212531.33333333 -1.10778096898084 1717410.0 -40000.0 -0.192864420866731 -1.5573 -0.9123 2069888 Maybridge1_000878 Cc1ccc(SC(=O)c2cccnc2Oc3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P21 compound treatment 1458820.0 -20000.0 -0.1 1501370.0 -33900.0 -0.15 1515210.0 -116961.33333333 -0.609639704137537 1813790.0 56380.0 0.271842401211658 -0.2929 -0.4238 1389928 Maybridge1_000879 S=C1NCN(CCN2CCCC2)CN1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P22 compound treatment 1446170.0 -32600.0 -0.16 1415240.0 -120000.0 -0.53 1364250.0 -267921.33333333 -1.39649128246489 1792800.0 35390.0 0.170636796361841 -0.9589 -0.6339 2069889 Maybridge1_000880 C/C(=N\O)/COc1ccc(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P23 mock treatment 1377050.0 -102000.0 -0.5 1496320.0 -38900.0 -0.17 1464750.0 -167421.33333333 -0.872653288149185 1829890.0 72480.0 0.349470330610517 -0.5969 -0.5538 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.543 P24 mock treatment 1474020.0 -4800.0 -0.02 1365500.0 -170000.0 -0.75 1415950.0 -216221.33333333 -1.12701442369751 1777120.0 19710.0 0.0950339433820819 -0.9041 -0.6654 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A01 compound treatment 1539200.0 -205000.0 -1.0 1603480.0 -178000.0 -0.79 1605280.0 -268690.37037037 -1.40049974832596 1496240.0 -319059.375 -1.53838003953691 -2.3651 -0.9691 2069890 Maybridge1_000881 Clc1cc(Cl)cc(Br)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A02 compound treatment 1534880.0 -209000.0 -1.02 1611040.0 -170000.0 -0.75 1643550.0 -230420.37037037 -1.20102432501788 1457640.0 -357659.375 -1.7244942056733 -2.3522 -0.9575 2069891 Maybridge1_000882 Fc1cc2[nH]c(S)nc2cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A03 compound treatment 1514930.0 -229000.0 -1.12 1666660.0 -114000.0 -0.51 1711590.0 -162380.37037037 -0.846378184388621 1473010.0 -342289.375 -1.65038605195526 -2.0633 -0.9267 1488119 Maybridge1_000883 Clc1ccc(cc1)C(=O)CNc2cccc(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A04 compound treatment 1615360.0 -129000.0 -0.63 1641240.0 -140000.0 -0.62 1625890.0 -248080.37037037 -1.29307386710361 1446080.0 -369219.375 -1.78023202330379 -2.1622 -0.9118 1497445 Maybridge1_000884 CCOC(=O)c1cnc2cc(Cl)c(F)cc2c1N3CCOCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A05 compound treatment 1715520.0 -28800.0 -0.14 1760030.0 -21100.0 -0.09 1676480.0 -197490.37037037 -1.02938268170628 1488960.0 -326339.375 -1.57348136413465 -1.4186 -0.7514 1022907 Maybridge1_000885 CC(=O)c1cc2ccccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A06 compound treatment 1706330.0 -38000.0 -0.19 1591940.0 -189000.0 -0.84 1727540.0 -146430.37037037 -0.76324170668379 1538580.0 -276719.375 -1.33423305004947 -1.5611 -0.8865 2069892 Maybridge1_000886 [O-][N+](=O)c1ccc(Oc2ccccc2F)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A07 compound treatment 1472030.0 -272000.0 -1.33 1529620.0 -251000.0 -1.12 1542940.0 -331030.37037037 -1.72543567435224 1316810.0 -498489.375 -2.40352161543985 -3.2883 -0.9584 1472485 Maybridge1_000887 Cc1onc(c1C(=O)Nc2ccc(Br)cn2)c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A08 compound treatment 1653530.0 -90800.0 -0.44 1684060.0 -97000.0 -0.43 1688820.0 -185150.37037037 -0.965062673250001 1541960.0 -273339.375 -1.31793600648623 -1.5788 -0.9039 2069893 Maybridge1_000888 [O-][N+](=O)c1cc(Cl)ccc1Oc2c(Cl)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A09 compound treatment 1691210.0 -53100.0 -0.26 1523200.0 -258000.0 -1.14 1701660.0 -172310.37037037 -0.898136505618024 1515520.0 -299779.375 -1.44541938867914 -1.8735 -0.9065 1619653 Maybridge1_000889 CC(=O)Nc1ccc(CC(C#N)C#N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A10 compound treatment 1786140.0 41800.0 0.2 1553200.0 -228000.0 -1.01 1785850.0 -88120.3703703701 -0.459311423613652 1628040.0 -187259.375 -0.902891772781027 -1.0841 -0.7499 1480482 Maybridge1_000890 CC(=O)Nc1c(F)cc(F)cc1C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A11 compound treatment 1853760.0 109000.0 0.54 1734280.0 -46800.0 -0.21 1823400.0 -50570.3703703701 -0.263588869518579 1656160.0 -159139.375 -0.767308084911715 -0.3514 -0.3535 1657436 Maybridge1_000891 Clc1ccc(Cl)c(NC(=S)NCCc2ccncc2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A12 compound treatment 1802460.0 58200.0 0.28 1725120.0 -56000.0 -0.25 1755440.0 -118530.37037037 -0.617818024679728 1566760.0 -248539.375 -1.19836006554886 -0.8899 -0.6356 2069894 Maybridge1_000892 [O-][N+](=O)c1cccnc1Sc2cc(Cl)ccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A13 compound treatment 1776080.0 31800.0 0.16 1619590.0 -162000.0 -0.72 1723260.0 -150710.37037037 -0.785550429227782 1581990.0 -233309.375 -1.12492693730385 -1.2356 -0.7943 1208589 Maybridge1_000893 Cc1onc(c1C(=O)NCCc2ccncc2)c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A14 compound treatment 1254880.0 -489000.0 -2.39 1156020.0 -625000.0 -2.77 1160070.0 -713900.37037037 -3.72107600155279 1118280.0 -697019.375 -3.36075595230665 -6.1244 -0.9863 2069895 Maybridge1_000894 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)Nc3ccc(F)cc3F)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A15 compound treatment 1433470.0 -311000.0 -1.52 1334970.0 -446000.0 -1.98 1427840.0 -446130.37037037 -2.32537351659839 1276320.0 -538979.375 -2.5987486254622 -4.2118 -0.9822 2069896 Maybridge1_000895 Clc1ccc2OC(=O)N(C(OC(=O)Nc3ccccc3)c2c1)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A16 compound treatment 1797500.0 53200.0 0.26 1575330.0 -206000.0 -0.91 1786030.0 -87940.3703703701 -0.4583732063104 1596750.0 -218549.375 -1.05375996600403 -1.0822 -0.7261 2069897 Maybridge1_000896 Cc1ccccc1C(=O)NCC(=O)c2ccc(Br)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A17 compound treatment 1774910.0 30600.0 0.15 1725790.0 -55300.0 -0.25 1787310.0 -86660.3703703701 -0.451701438820608 1626140.0 -189159.375 -0.912052832772197 -0.7296 -0.6899 2069898 Maybridge1_000897 Clc1ccc(SCc2ccc(cc2)c3nc4ccccc4s3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A18 compound treatment 1776080.0 31800.0 0.16 1782680.0 1580.0 0.01 1764450.0 -109520.37037037 -0.570855036333613 1664250.0 -151049.375 -0.728301255791419 -0.5683 -0.6056 1045890 Maybridge1_000898 COc1ccccc1Oc2ccccc2[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A19 compound treatment 1709890.0 -34400.0 -0.17 1616440.0 -165000.0 -0.73 1618910.0 -255060.37037037 -1.32945584919638 1608410.0 -206889.375 -0.997539987321376 -1.6128 -0.8846 2069899 Maybridge1_000899 CSC1=NCCN1C(=O)c2c(C)onc2c3c(F)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A20 compound treatment 1729550.0 -14700.0 -0.07 1598430.0 -183000.0 -0.81 1750880.0 -123090.37037037 -0.641586196362112 1590940.0 -224359.375 -1.08177352313492 -1.3028 -0.8698 2069900 Maybridge1_000900 CC(C)(C)C(=O)Nc1ccc(F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A21 compound treatment 1764570.0 20300.0 0.1 1570750.0 -210000.0 -0.93 1694020.0 -179950.37037037 -0.937958617822721 1612270.0 -203029.375 -0.978928570707736 -1.3753 -0.8342 1250979 Maybridge1_000901 O=C(Nc1nccs1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A22 compound treatment 1051130.0 -693000.0 -3.39 1006610.0 -774000.0 -3.43 947520.0 -926450.37037037 -4.82895426714288 975680.0 -839619.375 -4.04831761269655 -7.8519 -0.9892 1244212 Maybridge1_000902 Cn1sc(=O)c2cc(ccc12)S(=O)(=O)NC3CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A23 mock treatment 1858980.0 115000.0 0.56 1673050.0 -108000.0 -0.48 1783730.0 -90240.3703703701 -0.47036153851862 1654240.0 -161059.375 -0.776565577113318 -0.5825 -0.4978 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 A24 mock treatment 1777130.0 32800.0 0.16 1786300.0 5200.0 0.02 1768320.0 -105650.37037037 -0.550683364313695 1749700.0 -65599.375 -0.316294636714864 -0.3416 -0.5212 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B01 compound treatment 1647870.0 -96400.0 -0.47 1705690.0 -75400.0 -0.33 1653970.0 -220000.37037037 -1.14671196779629 1335590.0 -479709.375 -2.31297176984292 -2.133 -0.8062 1364313 Maybridge1_000903 COc1cc2CCN(C(C)c2cc1OC)C(=O)c3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B02 compound treatment 1731600.0 -12700.0 -0.06 1684340.0 -96800.0 -0.43 1760170.0 -113800.37037037 -0.593163758877606 1267360.0 -547939.375 -2.64195025573634 -1.8632 -0.6794 2069901 Maybridge1_000904 Cc1cc(NC(=O)c2cccs2)c(cc1C)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B03 compound treatment 1578120.0 -166000.0 -0.81 1619360.0 -162000.0 -0.72 1633980.0 -239990.37037037 -1.25090621164078 1334930.0 -480369.375 -2.31615403278722 -2.5488 -0.8953 2069902 Maybridge1_000905 CSC1=NCCN1CC(=O)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B04 compound treatment 1711880.0 -32400.0 -0.16 1519540.0 -262000.0 -1.16 1729140.0 -144830.37037037 -0.75490199732155 1264990.0 -550309.375 -2.6533774726727 -2.3634 -0.7886 1571188 Maybridge1_000906 Clc1ccc(Oc2ccccc2NC(=O)c3cccs3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B05 compound treatment 1647780.0 -96500.0 -0.47 1766880.0 -14200.0 -0.06 1723080.0 -150890.37037037 -0.786488646531034 1377320.0 -437979.375 -2.1117659627737 -1.7168 -0.7454 2069903 Maybridge1_000907 COc1ccc(OC)c(c1)S(=O)(=O)N2CCC(CCCC3CCN(CC3)S(=O)(=O)c4cc(OC)ccc4OC)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B06 compound treatment 1775530.0 31200.0 0.15 1803520.0 22400.0 0.1 1806120.0 -67850.3703703701 -0.353657730630772 1379160.0 -436139.375 -2.10289419941383 -1.1021 -0.515 1632115 Maybridge1_000908 Clc1ccc(Oc2ccccc2NC(=O)NC(=O)c3c(Cl)cccc3Cl)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B07 compound treatment 1608160.0 -136000.0 -0.67 1577280.0 -204000.0 -0.9 1659930.0 -214040.37037037 -1.11564655042195 1261380.0 -553919.375 -2.67078348665592 -2.6782 -0.8627 2069904 Maybridge1_000909 CN(NC(=O)NC(=O)c1c(Cl)cccc1Cl)c2cccc(F)c2C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B08 compound treatment 1531520.0 -213000.0 -1.04 1447840.0 -333000.0 -1.48 1731140.0 -142830.37037037 -0.74447736061875 1256600.0 -558699.375 -2.6938307849495 -2.9787 -0.8949 2069905 Maybridge1_000910 C/C(=N\Nc1c(Cl)cc(Cl)cc1Cl)/c2cc(Br)ccc2O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B09 compound treatment 1732930.0 -11400.0 -0.06 1725760.0 -55300.0 -0.25 1813770.0 -60200.3703703701 -0.313783495242561 1525150.0 -290149.375 -1.39898727935548 -1.0069 -0.6917 2069906 Maybridge1_000911 CSC1=NCCN1CC(=O)c2ccc(C)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B10 compound treatment 1651100.0 -93200.0 -0.46 1473120.0 -308000.0 -1.37 1706210.0 -167760.37037037 -0.874420457119154 1305660.0 -509639.375 -2.45728257275645 -2.5768 -0.8649 2069907 Maybridge1_000912 COc1ccc(/C=C/2\SC(=S)NC2=O)cc1Br 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B11 compound treatment 1799000.0 54700.0 0.27 1550490.0 -231000.0 -1.02 1748810.0 -125160.37037037 -0.65237569534951 1389890.0 -425409.375 -2.05115831851633 -1.7293 -0.7211 1295895 Maybridge1_000913 NNC(=O)CNC(=O)c1c(F)cccc1F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B12 compound treatment 1739520.0 -4780.0 -0.02 1705140.0 -76000.0 -0.34 1880060.0 6089.6296296299 0.0317410882717496 1479850.0 -335449.375 -1.61740623598705 -0.973 -0.5887 2069908 Maybridge1_000914 CN(C)/C=N/c1nnc(s1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B13 compound treatment 1290660.0 -454000.0 -2.22 1472920.0 -308000.0 -1.37 1446240.0 -427730.37037037 -2.22946685893263 1351970.0 -463329.375 -2.23399378949799 -4.025 -0.9833 2069909 Maybridge1_000915 Brc1cc(cc(Br)c1n2cccc2)C3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B14 compound treatment 1559840.0 -184000.0 -0.9 1604760.0 -176000.0 -0.78 1700920.0 -173050.37037037 -0.90199362119806 1553060.0 -262239.375 -1.26441612969572 -1.9255 -0.9828 1625161 Maybridge1_000916 Cc1ncc(COn2c(nc3ccccc3c2=O)c4ccccc4)c(CO)c1O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B15 compound treatment 1426280.0 -318000.0 -1.56 1477010.0 -304000.0 -1.35 1607960.0 -266010.37037037 -1.38653073514421 1437560.0 -377739.375 -1.8213121449484 -3.0563 -0.9926 2069910 Maybridge1_000917 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)NC(=N)c3cccnc3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B16 compound treatment 1365520.0 -379000.0 -1.85 1262180.0 -519000.0 -2.3 1420590.0 -453380.37037037 -2.36316282464604 1269450.0 -545849.375 -2.63187308974606 -4.5749 -0.9926 2069911 Maybridge1_000918 CC(C)(C)c1csc(Cc2ccc(Cl)cc2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B17 compound treatment 1740740.0 -3560.0 -0.02 1426600.0 -354000.0 -1.57 1809130.0 -64840.3703703701 -0.337968652393058 1609770.0 -205529.375 -0.990982597011907 -1.4592 -0.7725 2069912 Maybridge1_000919 COc1ccc(cc1OC)S(=O)(=O)NNc2c(Cl)cc(Cl)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B18 compound treatment 1779290.0 35000.0 0.17 1402100.0 -379000.0 -1.68 1757440.0 -116530.37037037 -0.607393387976928 1518790.0 -296509.375 -1.42965272227329 -1.7733 -0.7727 1708614 Maybridge1_000920 Clc1cccc(Cl)c1C(=O)NC(=O)N2CCc3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B19 compound treatment 1741880.0 -2420.0 -0.01 1367520.0 -414000.0 -1.83 1774370.0 -99600.3703703701 -0.519148838287725 1613440.0 -201859.375 -0.973287286397384 -1.6692 -0.7799 2069913 Maybridge1_000921 Cc1ccc(NC(=S)Nc2ccc(C)c(C)c2)cc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B20 compound treatment 1313600.0 -431000.0 -2.11 1094960.0 -686000.0 -3.04 1376500.0 -497470.37037037 -2.59297394075927 1234240.0 -581059.375 -2.801641996214 -5.2725 -0.9916 2069914 Maybridge1_000922 Clc1cccc(NC(=S)NN=C2CCCCCC2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B21 compound treatment 1610100.0 -134000.0 -0.66 1236480.0 -545000.0 -2.42 1570730.0 -303240.37037037 -1.58058534736684 1516200.0 -299099.375 -1.44214069352441 -3.0473 -0.9254 1545633 Maybridge1_000923 CC(=O)Nc1cc2cc(NC(=O)c3c(C)onc3c4c(Cl)cccc4Cl)ccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B22 compound treatment 1089530.0 -655000.0 -3.2 977670.0 -803000.0 -3.56 1044360.0 -829610.37037037 -4.32419335799329 1071840.0 -743459.375 -3.58467154493293 -7.338 -0.9939 2069915 Maybridge1_000924 C/C(=N\NC(=S)N)/c1cc2cc(Cl)ccc2o1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B23 mock treatment 1859060.0 115000.0 0.56 1857170.0 76100.0 0.34 1577920.0 -296050.37037037 -1.54310877842027 1847840.0 32540.625 0.156898219881662 -0.2436 -0.1447 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 B24 mock treatment 1985890.0 242000.0 1.18 1664000.0 -117000.0 -0.52 1821120.0 -52850.3703703701 -0.275472955359771 1784960.0 -30339.375 -0.14628464972084 0.1206 0.0908 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C01 compound treatment 1299840.0 -444000.0 -2.17 1696970.0 -84100.0 -0.37 1754520.0 -119450.37037037 -0.622613357563016 1534180.0 -281119.375 -1.35544813634481 -2.263 -0.8496 2069916 Maybridge1_000925 Cc1ccc(cc1)n2nnc(n2)c3ccc(Cl)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C02 compound treatment 1099680.0 -645000.0 -3.15 1181070.0 -600000.0 -2.66 1187450.0 -686520.37037037 -3.57836272509146 1034880.0 -780419.375 -3.76287826981379 -6.5783 -0.9918 1116479 Maybridge1_000926 On1c(nc2ccccc2c1=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C03 compound treatment 1754320.0 10000.0 0.05 1776990.0 -4110.0 -0.02 1691440.0 -182530.37037037 -0.951406399169333 1318630.0 -496669.375 -2.39474628429041 -1.6577 -0.6432 2069917 Maybridge1_000927 COc1ccc(cc1)c2c(C#N)c([nH]c(=O)c2C#N)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C04 compound treatment 929700.0 -815000.0 -3.99 899680.0 -881000.0 -3.91 925530.0 -948440.37037037 -4.94357314769017 784080.0 -1031219.375 -4.97213818864819 -8.9054 -0.9936 2069918 Maybridge1_000928 CC(C)(C)c1ccc(cc1)C(=O)N/N=C/c2cc(Cl)cc(Cl)c2O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C05 compound treatment 1621820.0 -122000.0 -0.6 1828640.0 47500.0 0.21 1711460.0 -162510.37037037 -0.847055785774303 1325120.0 -490179.375 -2.36345403200478 -1.7995 -0.6948 1781213 Maybridge1_000929 CC(=O)Nc1cc2cc(ccc2oc1=O)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C06 compound treatment 1744640.0 340.0 0.0 1784850.0 3750.0 0.02 1798880.0 -75090.3703703701 -0.391394915494909 1438010.0 -377289.375 -1.81914242021365 -1.0961 -0.589 2069919 Maybridge1_000930 N#Cc1ccccc1N2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C07 compound treatment 1757920.0 13600.0 0.07 1847280.0 66200.0 0.29 1840900.0 -33070.3703703701 -0.172373298369077 1464430.0 -350869.375 -1.69175547023118 -0.752 -0.4354 1019504 Maybridge1_000931 CCC(=O)c1ccc(cc1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C08 compound treatment 1336960.0 -407000.0 -1.99 1726250.0 -54800.0 -0.24 1802970.0 -71000.3703703701 -0.370076533437682 1512890.0 -302409.375 -1.45810022435113 -2.0323 -0.81 2069920 Maybridge1_000932 [O-][N+](=O)c1cc(ccc1Oc2c(Cl)cccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C09 compound treatment 1875880.0 132000.0 0.64 1741070.0 -40000.0 -0.18 1980320.0 106349.62962963 0.554328126183121 1462240.0 -353059.375 -1.70231479727363 -0.3408 -0.1784 2069921 Maybridge1_000933 [O-][N+](=O)c1ccc2oc(=O)c(NC(=O)c3c(F)cccc3F)cc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C10 compound treatment 1607090.0 -137000.0 -0.67 1671840.0 -109000.0 -0.48 1663600.0 -210370.37037037 -1.09651734207231 1311940.0 -503359.375 -2.42700285868037 -2.3397 -0.8389 2069922 Maybridge1_000934 CC(C)(C)NC(=S)N/N=C/c1ccccc1SC(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C11 compound treatment 1749200.0 4900.0 0.02 1653050.0 -128000.0 -0.57 1790300.0 -83670.3703703701 -0.436116606949921 1553520.0 -261779.375 -1.26219818885575 -1.1211 -0.7725 1708697 Maybridge1_000935 Cc1ccc(cc1)S(=O)(=O)NCCc2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C12 compound treatment 1730620.0 -13700.0 -0.07 1657230.0 -124000.0 -0.55 1815680.0 -58290.3703703701 -0.303827967191387 1579160.0 -236139.375 -1.13857209508017 -1.0293 -0.7906 2069923 Maybridge1_000936 Cc1ccc(Sc2ncccc2[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C13 compound treatment 1691700.0 -52600.0 -0.26 1626370.0 -155000.0 -0.69 1791100.0 -82870.3703703701 -0.431946752268801 1654320.0 -160979.375 -0.776179848271585 -1.0758 -0.9342 2069924 Maybridge1_000937 CCOC(=O)CNC(=O)c1c(C)onc1c2c(Cl)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C14 compound treatment 1679530.0 -64800.0 -0.32 1620160.0 -161000.0 -0.71 1740770.0 -133200.37037037 -0.694282734894767 1540070.0 -275229.375 -1.32704885037219 -1.526 -0.9035 1019893 Maybridge1_000938 NCC(=O)c1ccc(Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C15 compound treatment 1937200.0 193000.0 0.94 1759200.0 -21900.0 -0.1 1893770.0 19799.6296296299 0.103201972869445 1715810.0 -99489.375 -0.479699017294202 0.2352 0.2201 2069925 Maybridge1_000939 Cc1nn(c(C)c1N=Nc2cc(Cl)cc(Cl)c2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C16 compound treatment 520580.0 -1220000.0 -5.99 551680.0 -1230000.0 -5.45 476000.0 -1397970.37037037 -7.28666661619504 444600.0 -1370699.375 -6.60897852854414 -12.668 -0.9942 2069926 Maybridge1_000940 C/C(=N\NC(=S)NC(C)(C)C)/c1cc(F)ccc1O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C17 compound treatment 1382320.0 -362000.0 -1.77 1347910.0 -433000.0 -1.92 1382330.0 -491640.37037037 -2.56258612477061 1279130.0 -536169.375 -2.58519989989631 -4.4201 -0.9864 1556471 Maybridge1_000941 Clc1cccc(N2CCCCC2)c1C(C#N)N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C18 compound treatment 1709450.0 -34800.0 -0.17 1605010.0 -176000.0 -0.78 1838080.0 -35890.3703703701 -0.187072036120026 1601070.0 -214229.375 -1.03293060855042 -1.0857 -0.8229 2069927 Maybridge1_000942 NC(=S)NNC(=O)c1ccccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C19 compound treatment 1805790.0 61500.0 0.3 1702080.0 -79000.0 -0.35 1840430.0 -33540.3703703701 -0.174823087994235 1571250.0 -244049.375 -1.17671103430657 -0.7005 -0.5489 2069928 Maybridge1_000943 CSC1=NCCN1C(=O)c2c(C)onc2c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C20 compound treatment 1821500.0 77200.0 0.38 1499930.0 -281000.0 -1.25 1852160.0 -21810.3703703701 -0.113682593732313 1447240.0 -368059.375 -1.77463895509865 -1.3787 -0.6254 2069929 Maybridge1_000944 CC(C)(C)C(=O)Nc1ccc(F)cc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C21 compound treatment 1530240.0 -214000.0 -1.05 1372870.0 -408000.0 -1.81 1636390.0 -237580.37037037 -1.23834452441391 1574570.0 -240729.375 -1.16070328737463 -2.6285 -0.9758 2069930 Maybridge1_000945 Cc1onc(c1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-])c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C22 compound treatment 1173990.0 -570000.0 -2.79 1201080.0 -580000.0 -2.57 1269410.0 -604560.37037037 -3.15116111301071 1275060.0 -540239.375 -2.6048238547195 -5.5595 -0.9966 2069931 Maybridge1_000946 Fc1cccc(Cl)c1CSC2=NCN(CN2)C3CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C23 mock treatment 1802330.0 58000.0 0.28 1552480.0 -229000.0 -1.01 1564800.0 -309170.37037037 -1.61149439519064 1795320.0 -19979.375 -0.0963327647163563 -1.2189 -0.6324 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 C24 mock treatment 1533120.0 -211000.0 -1.03 1589040.0 -192000.0 -0.85 1541840.0 -332130.37037037 -1.73116922453878 1854970.0 39670.625 0.191276302901157 -1.7125 -0.7795 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D01 compound treatment 1047710.0 -697000.0 -3.41 1118150.0 -663000.0 -2.94 1178880.0 -695090.37037037 -3.62303229336296 962080.0 -853219.375 -4.11389151579124 -7.0428 -0.9929 2069932 Maybridge1_000947 COc1cc2CCN(C(C)c2cc1OC)C(=O)Nc3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D02 compound treatment 1684800.0 -59500.0 -0.29 1621230.0 -160000.0 -0.71 1654560.0 -219410.37037037 -1.14363669996897 1402590.0 -412709.375 -1.98992386489114 -2.0668 -0.8542 2069933 Maybridge1_000948 COC(OC)C(C)NC(=O)NC(=O)c1ccccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D03 compound treatment 1789220.0 44900.0 0.22 1539840.0 -241000.0 -1.07 1639370.0 -234600.37037037 -1.22281181572673 1401300.0 -413999.375 -1.99614374246409 -2.0345 -0.7876 2069934 Maybridge1_000949 COC(=O)/C=C/1\Nc2ccccc2C(=O)NC1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D04 compound treatment 1747530.0 3230.0 0.02 1642750.0 -138000.0 -0.61 1715840.0 -158130.37037037 -0.824225831395171 1522560.0 -292739.375 -1.4114752506066 -1.4167 -0.8114 1544141 Maybridge1_000950 Fc1cccc(F)c1C(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D05 compound treatment 1586570.0 -158000.0 -0.77 1460770.0 -320000.0 -1.42 1572060.0 -301910.37037037 -1.57365296395947 1085230.0 -730069.375 -3.52011018004779 -3.6431 -0.8713 2069935 Maybridge1_000951 Clc1ccccc1C(=O)NC(=O)Nc2cccc(C#C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D06 compound treatment 1766770.0 22500.0 0.11 1567730.0 -213000.0 -0.95 1825040.0 -48930.3703703701 -0.255040667422283 1373920.0 -441379.375 -2.12815943854737 -1.6097 -0.6863 1494826 Maybridge1_000952 Fc1cccc(F)c1C(=O)NC(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D07 compound treatment 1476820.0 -267000.0 -1.31 1261800.0 -519000.0 -2.3 1432120.0 -441850.37037037 -2.3030647940544 1069450.0 -745849.375 -3.59619519407972 -4.7555 -0.9463 2069936 Maybridge1_000953 CN(NC(=O)NC(=O)c1c(Cl)cccc1Cl)c2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D08 compound treatment 1736740.0 -7560.0 -0.04 1625860.0 -155000.0 -0.69 1760900.0 -113070.37037037 -0.589358766481084 1368960.0 -446339.375 -2.15207462673485 -1.7334 -0.7422 2069937 Maybridge1_000954 CC(=O)c1cc(Cl)ccc1OC(=O)c2c(C)onc2c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D09 compound treatment 1603840.0 -140000.0 -0.69 1445870.0 -335000.0 -1.49 1698850.0 -175120.37037037 -0.912783120185458 1186140.0 -629159.375 -3.03356146230624 -3.0602 -0.8581 1666692 Maybridge1_000955 Fc1ccc(NC(=O)c2c(F)cccc2NC(=O)c3cccs3)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D10 compound treatment 1787520.0 43200.0 0.21 1534580.0 -247000.0 -1.09 1692590.0 -181380.37037037 -0.945412233065223 1580670.0 -234629.375 -1.13129146319245 -1.4792 -0.8006 2069938 Maybridge1_000956 [O-][N+](=O)c1ccc2oc3ncccc3c(=O)c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D11 compound treatment 1773350.0 29100.0 0.14 1539580.0 -242000.0 -1.07 1767520.0 -106450.37037037 -0.554853218994815 1562080.0 -253219.375 -1.22092520279027 -1.3523 -0.7853 2069939 Maybridge1_000957 CCC(C)(OC(=O)NC(=O)c1c(F)cccc1Cl)C#C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D12 compound treatment 1831120.0 86800.0 0.42 1733600.0 -47500.0 -0.21 1739910.0 -134060.37037037 -0.698765328676971 1735360.0 -79939.375 -0.385436531595587 -0.435 -0.4686 1099054 Maybridge1_000958 OC(=O)C1CSC(N1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D13 compound treatment 1375910.0 -368000.0 -1.8 1495850.0 -285000.0 -1.26 1509300.0 -364670.37037037 -1.90077806369334 1466180.0 -349119.375 -1.68331765181826 -3.3259 -0.9895 2069940 Maybridge1_000959 Clc1cc(Br)cc(Cl)c1n2cccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D14 compound treatment 1205670.0 -539000.0 -2.64 1280320.0 -501000.0 -2.22 1352120.0 -521850.37037037 -2.72005026216641 1299920.0 -515379.375 -2.48495861715083 -5.0308 -0.9972 1230634 Maybridge1_000960 Clc1ccccc1C(=O)On2c(nc3ccccc3c2=O)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D15 compound treatment 1573510.0 -171000.0 -0.84 1373140.0 -408000.0 -1.81 1661800.0 -212170.37037037 -1.10589951510483 1507720.0 -307579.375 -1.48302795074816 -2.6169 -0.9624 2069941 Maybridge1_000961 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)NC(=N)c3ccccn3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D16 compound treatment 1260580.0 -484000.0 -2.37 1176340.0 -605000.0 -2.68 1357160.0 -516810.37037037 -2.69378017767535 1290260.0 -525039.375 -2.53153537479014 -5.1371 -0.9987 1172112 Maybridge1_000962 Cc1onc(c1C(=O)On2c(nc3ccccc3c2=O)c4ccccc4)c5ccccc5 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D17 compound treatment 1472030.0 -272000.0 -1.33 1458490.0 -323000.0 -1.43 1632250.0 -241720.37037037 -1.2599235223887 1318080.0 -497219.375 -2.39739817007733 -3.2102 -0.9611 2069942 Maybridge1_000963 COc1ccc(cc1OC)S(=O)(=O)N2CCN(CC2)c3ccc(cc3[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D18 compound treatment 1202000.0 -542000.0 -2.65 1317440.0 -464000.0 -2.06 1502120.0 -371850.37037037 -1.9382025094564 1316250.0 -499049.375 -2.40622171733198 -4.5272 -0.9922 2069943 Maybridge1_000964 NNC(=S)Nc1cccc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D19 compound treatment 1803870.0 59600.0 0.29 1687790.0 -93300.0 -0.41 1730680.0 -143290.37037037 -0.746875027060394 1682720.0 -132579.375 -0.639246109456205 -0.7542 -0.6821 1615615 Maybridge1_000965 Clc1ccc(NC(=S)NCCn2ccnc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D20 compound treatment 1037880.0 -706000.0 -3.46 884370.0 -897000.0 -3.98 1073970.0 -800000.37037037 -4.16985661160834 966600.0 -848699.375 -4.0920978362333 -7.8478 -0.9975 2069944 Maybridge1_000966 Cc1ccc(CSc2nc(C(=O)C(F)(F)F)c3ccccn23)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D21 compound treatment 1623090.0 -121000.0 -0.59 1205300.0 -576000.0 -2.55 1544000.0 -329970.37037037 -1.71991061689976 1499280.0 -316019.375 -1.52372234355104 -3.1951 -0.9166 2069945 Maybridge1_000967 CN(C)/C=N/C(=S)Nc1cccc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D22 compound treatment 1508210.0 -236000.0 -1.16 1395290.0 -386000.0 -1.71 1554260.0 -319710.37037037 -1.6664322306144 1490340.0 -324959.375 -1.56682754161475 -3.0497 -0.9898 2069946 Maybridge1_000968 N/C(=N\O)/CC(=O)Nc1ccc(F)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D23 mock treatment 1576510.0 -168000.0 -0.82 1403610.0 -377000.0 -1.67 1611840.0 -262130.37037037 -1.36630693994078 1840240.0 24940.625 0.120253979916983 -1.8706 -0.8081 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 D24 mock treatment 1872320.0 128000.0 0.63 1780700.0 -397.0 0.0 1909690.0 35719.6296296299 0.186182081023734 1876060.0 60760.625 0.292964068803141 0.5519 0.7706 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E01 compound treatment 1344020.0 -400000.0 -1.96 1377440.0 -404000.0 -1.79 1351060.0 -522910.37037037 -2.72557531961889 1260230.0 -555069.375 -2.67632833875584 -4.5754 -0.9837 2069947 Maybridge1_000969 CC(C)(C)SCC(=O)Nc1cc(ccc1Oc2ccc(C#N)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E02 compound treatment 1524500.0 -220000.0 -1.08 1538560.0 -243000.0 -1.08 1586910.0 -287060.37037037 -1.49625003644118 1362400.0 -452899.375 -2.18370439175699 -2.9156 -0.955 2069948 Maybridge1_000970 Fc1ccc(/N=C/c2c(F)cccc2Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E03 compound treatment 1779600.0 35300.0 0.17 1706240.0 -74900.0 -0.33 1608260.0 -265710.37037037 -1.38496703963879 1445810.0 -369489.375 -1.78153385814464 -1.6629 -0.727 2069949 Maybridge1_000971 FC(F)(F)c1cc(NCC(=O)c2ccc(Cl)cc2)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E04 compound treatment 1515050.0 -229000.0 -1.12 1681080.0 -100000.0 -0.44 1678780.0 -195190.37037037 -1.01739434949806 1274240.0 -541059.375 -2.60877757534727 -2.5958 -0.8514 2069950 Maybridge1_000972 [O-][N+](=O)c1ccc(Oc2ccc(cc2)c3ccccc3)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E05 compound treatment 1804860.0 60600.0 0.3 1602410.0 -179000.0 -0.79 1813120.0 -60850.3703703701 -0.317171502170972 1453660.0 -361639.375 -1.74368421554954 -1.2785 -0.651 1104647 Maybridge1_000973 Nc1c(C#N)cnn1CCC#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E06 compound treatment 1775680.0 31400.0 0.15 1773230.0 -7870.0 -0.03 1829000.0 -44970.3703703701 -0.234399886750738 1523390.0 -291909.375 -1.40747331387361 -0.7616 -0.5305 1104603 Maybridge1_000974 NC(=O)c1ccccc1N2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E07 compound treatment 1825040.0 80700.0 0.4 1859260.0 78200.0 0.35 1868050.0 -5920.3703703701 -0.0308588551285654 1511200.0 -304099.375 -1.46624874613275 -0.3777 -0.2424 1106751 Maybridge1_000975 Nc1cc2cc(ccc2oc1=O)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E08 compound treatment 1510730.0 -234000.0 -1.14 1536260.0 -245000.0 -1.09 1409600.0 -464370.37037037 -2.42044620332793 1394760.0 -420539.375 -2.0276770752758 -3.3384 -0.9459 2069951 Maybridge1_000976 [O-][N+](=O)c1ccc(Oc2c(Cl)cccc2Cl)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E09 compound treatment 1806350.0 62100.0 0.3 1752910.0 -28200.0 -0.13 1796160.0 -77810.3703703701 -0.405572421410717 1522360.0 -292939.375 -1.41243957271093 -0.8197 -0.5444 1516140 Maybridge1_000977 CNc1ccccc1C(=O)NCCc2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E10 compound treatment 1775140.0 30800.0 0.15 1701660.0 -79400.0 -0.35 1922920.0 48949.6296296299 0.255141052812757 1710110.0 -105189.375 -0.507182197267711 -0.2267 -0.331 1122977 Maybridge1_000978 Cn1[nH]c(=O)c2cnc3c(F)cc(F)cc3c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E11 compound treatment 1803530.0 59200.0 0.29 1733790.0 -47300.0 -0.21 1808500.0 -65470.3703703701 -0.34125241295444 1587120.0 -228179.375 -1.10019207532769 -0.6807 -0.5643 1967118 Maybridge1_000979 FC(F)(F)c1cc(cc(c1)S(=O)(=O)NCCc2ccncc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E12 compound treatment 1530480.0 -214000.0 -1.05 1753780.0 -27300.0 -0.12 1696560.0 -177410.37037037 -0.924719329210164 1572640.0 -242659.375 -1.17000899568145 -1.6311 -0.8934 2069952 Maybridge1_000980 [O-][N+](=O)c1cccnc1Sc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E13 compound treatment 1848000.0 104000.0 0.51 1617540.0 -164000.0 -0.73 1880980.0 7009.6296296299 0.0365364211550376 1604090.0 -211209.375 -1.01836934477498 -0.5999 -0.4444 1352645 Maybridge1_000981 N#CC(N1CCOCC1)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E14 compound treatment 1790940.0 46600.0 0.23 1676580.0 -105000.0 -0.46 1715970.0 -158000.37037037 -0.823548230009489 1487400.0 -327899.375 -1.58100307654845 -1.3199 -0.7112 2069953 Maybridge1_000982 CC1CCN(CC1)S(=O)(=O)c2cc(Cl)c(Oc3ccc(cc3Cl)[N+](=O)[O-])c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E15 compound treatment 1637290.0 -107000.0 -0.52 1567280.0 -214000.0 -0.95 1914950.0 40979.6296296299 0.213598875552098 1588480.0 -226819.375 -1.09363468501822 -1.176 -0.7567 1411187 Maybridge1_000983 CC(C)(C)NC(=O)NC(=O)c1c(F)cccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E16 compound treatment 1576210.0 -168000.0 -0.82 1451630.0 -329000.0 -1.46 1723230.0 -150740.37037037 -0.785706798778324 1403840.0 -411459.375 -1.98389685173906 -2.5266 -0.931 1134663 Maybridge1_000984 Cc1onc(c1C(=O)NCC(=O)c2ccc(Br)cc2)c3c(F)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E17 compound treatment 1547840.0 -196000.0 -0.96 1393810.0 -387000.0 -1.72 1728270.0 -145700.37037037 -0.759436714287268 1531790.0 -283509.375 -1.3669717854916 -2.4026 -0.9558 2069954 Maybridge1_000985 COC(=O)c1nn(nc1C)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E18 compound treatment 672850.0 -1070000.0 -5.24 963010.0 -818000.0 -3.63 1008160.0 -865810.37037037 -4.51287928231398 1064740.0 -750559.375 -3.61890497963677 -8.5014 -0.9875 2069955 Maybridge1_000986 Fc1ccc(NC(=O)CS(=O)(=O)Cc2ccc(Cl)c(Cl)c2)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E19 compound treatment 1656800.0 -87500.0 -0.43 1517530.0 -264000.0 -1.17 1775010.0 -98960.3703703701 -0.515812954542828 1697120.0 -118179.375 -0.569814917944182 -1.3413 -0.9168 2069956 Maybridge1_000987 CSC1=NCCN1C(=O)c2c(C)onc2c3ccccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E20 compound treatment 1386960.0 -357000.0 -1.75 1283560.0 -498000.0 -2.21 1499950.0 -374020.37037037 -1.94951324027893 1188840.0 -626459.375 -3.02054311389774 -4.4626 -0.9773 2069957 Maybridge1_000988 C/C(=N\O)/c1cc2ccccc2o1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E21 compound treatment 1124610.0 -620000.0 -3.03 1118300.0 -663000.0 -2.94 1258040.0 -615930.37037037 -3.21042517266613 1092450.0 -722849.375 -3.48529815208134 -6.3337 -0.9978 2069958 Maybridge1_000989 CC(=O)Nc1cc(Sc2ccc(Cl)cc2)c(F)cc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E22 compound treatment 1390320.0 -354000.0 -1.73 1239360.0 -542000.0 -2.4 1478290.0 -395680.37037037 -2.06241205577026 1468030.0 -347269.375 -1.67439767235317 -3.9357 -0.9892 2069959 Maybridge1_000990 N#Cc1cccc(CSC2=NCN(CN2)C3CC3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E23 mock treatment 1541800.0 -202000.0 -0.99 1456090.0 -325000.0 -1.44 1688160.0 -185810.37037037 -0.968502803361925 1821760.0 6460.625 0.0311506174765532 -1.6848 -0.8426 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 E24 mock treatment 1869190.0 125000.0 0.61 1469480.0 -312000.0 -1.38 1906200.0 32229.6296296299 0.167991089977348 1739900.0 -75399.375 -0.363546419827213 -0.4832 -0.3091 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F01 compound treatment 1633710.0 -111000.0 -0.54 1663150.0 -118000.0 -0.52 1707930.0 -166040.37037037 -0.865455269554746 1259600.0 -555699.375 -2.67936595338449 -2.3045 -0.7907 1593780 Maybridge1_000991 COc1cc2CCN(C(C)c2cc1OC)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F02 compound treatment 1602950.0 -141000.0 -0.69 1619450.0 -162000.0 -0.72 1754880.0 -119090.37037037 -0.620736922956512 1436480.0 -378819.375 -1.8265194843118 -1.9279 -0.888 2069960 Maybridge1_000992 Cc1cc(NC(=O)c2ccc(F)cc2)c(cc1C)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F03 compound treatment 1657370.0 -86900.0 -0.43 1671780.0 -109000.0 -0.48 1644520.0 -229450.37037037 -1.19596837621702 1189500.0 -625799.375 -3.01736085095344 -2.5618 -0.7741 2069961 Maybridge1_000993 COc1ccccc1Oc2ccc(cc2NC(=O)c3ccc(Cl)cc3Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F04 compound treatment 1813490.0 69200.0 0.34 1840740.0 59600.0 0.26 1792850.0 -81120.3703703701 -0.422825195153851 1410720.0 -404579.375 -1.95072417134998 -0.8852 -0.4336 2069962 Maybridge1_000994 FC(F)(F)c1cccc(c1)C(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F05 compound treatment 1719580.0 -24700.0 -0.12 1598790.0 -182000.0 -0.81 1814880.0 -59090.3703703701 -0.307997821872507 1632080.0 -183219.375 -0.883412466273487 -1.0604 -0.8535 2069963 Maybridge1_000995 Fc1cccc(F)c1C(=O)NC(=O)Nc2cccc(C#C)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F06 compound treatment 1578580.0 -166000.0 -0.81 1658900.0 -122000.0 -0.54 1740380.0 -133590.37037037 -0.696315539051813 1619520.0 -195779.375 -0.943971894425641 -1.4966 -0.981 1339372 Maybridge1_000996 Fc1cccc(Cl)c1C(=O)NC(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F07 compound treatment 1676390.0 -67900.0 -0.33 1819490.0 38400.0 0.17 1704370.0 -169600.37037037 -0.88401112288573 1582270.0 -233029.375 -1.12357688635778 -1.0848 -0.7342 2069964 Maybridge1_000997 CN(NC(=O)NC(=O)c1c(Cl)cccc1Cl)c2ccc(Cl)cc2[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F08 compound treatment 1749380.0 5080.0 0.02 1743040.0 -38100.0 -0.17 1783210.0 -90760.3703703701 -0.473071944061348 1488210.0 -327089.375 -1.5770975720259 -1.097 -0.6627 2069965 Maybridge1_000998 CC(=O)c1cc(F)cc(Cl)c1OC(=O)c2c(C)onc2c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F09 compound treatment 1680040.0 -64300.0 -0.31 1511310.0 -270000.0 -1.2 1689620.0 -184350.37037037 -0.960892818568881 1475780.0 -339519.375 -1.63703019081024 -2.0544 -0.9067 2069966 Maybridge1_000999 Fc1ccc(NC(=O)c2c(F)cccc2NC(=O)c3cccc(c3)C(F)(F)F)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F10 compound treatment 1623840.0 -120000.0 -0.59 1624450.0 -157000.0 -0.69 1652910.0 -221060.37037037 -1.15223702524878 1543170.0 -272129.375 -1.31210185775501 -1.8742 -0.9516 2069967 Maybridge1_001000 CCOc1ccc(Br)cc1/C=C/2\SC(=S)NC2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F11 compound treatment 1780810.0 36500.0 0.18 1622520.0 -159000.0 -0.7 1543060.0 -330910.37037037 -1.72481019615008 1616080.0 -199219.375 -0.96055823462018 -1.605 -0.7631 2069968 Maybridge1_001001 CCCc1ccc(NC(=O)C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F12 compound treatment 1598640.0 -146000.0 -0.71 1773120.0 -7980.0 -0.04 1744550.0 -129420.37037037 -0.674580171526475 1402950.0 -412349.375 -1.98818808510334 -1.7055 -0.7691 2069969 Maybridge1_001002 COc1cccc2sc(/N=C/N(C)C)nc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F13 compound treatment 1536060.0 -208000.0 -1.02 1520080.0 -261000.0 -1.16 1568030.0 -305940.37037037 -1.59465860691562 1254270.0 -561029.375 -2.70506513746498 -3.2381 -0.9256 2069970 Maybridge1_001003 Brc1ccc(NC(=O)CSc2ccccn2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F14 compound treatment 857670.0 -887000.0 -4.34 816000.0 -965000.0 -4.28 814740.0 -1059230.37037037 -5.52104589784178 828130.0 -987169.375 -4.75974624516871 -9.4497 -0.9945 1281600 Maybridge1_001004 COC(=O)c1ccc(Cl)cc1NC(=O)c2ccccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F15 compound treatment 1412350.0 -332000.0 -1.62 1292760.0 -488000.0 -2.17 1537510.0 -336460.37037037 -1.75373856300035 1307920.0 -507379.375 -2.44638573297748 -3.9951 -0.9868 2069971 Maybridge1_001005 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)NC(=N)c3ccncc3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F16 compound treatment 1948410.0 204000.0 1.0 1711840.0 -69300.0 -0.31 1873610.0 -360.370370370103 -0.00187836509478093 1730210.0 -85089.375 -0.410267825782178 0.1398 0.1245 2069972 Maybridge1_001006 Brc1ccc(COc2ccc(cc2)S(=O)(=O)c3ccc(OCc4ccc(Br)cc4)cc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F17 compound treatment 1678440.0 -65900.0 -0.32 1734210.0 -46900.0 -0.21 1864670.0 -9300.3703703701 -0.0484764911562976 1613540.0 -201759.375 -0.972805125345217 -0.7757 -0.7411 2069973 Maybridge1_001007 CN(C)/C=N/C(=S)c1ccc(Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F18 compound treatment 1380320.0 -364000.0 -1.78 1320420.0 -461000.0 -2.04 1729560.0 -144410.37037037 -0.752712823613962 1509080.0 -306219.375 -1.47647056043869 -3.0266 -0.9527 2069974 Maybridge1_001008 NNC(=S)Nc1cc(ccc1Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F19 compound treatment 1532190.0 -212000.0 -1.04 1599780.0 -181000.0 -0.8 1499720.0 -374250.37037037 -1.95071207349976 1772730.0 -42569.375 -0.205252946400843 -1.999 -0.8469 2069975 Maybridge1_001009 Clc1ccc(Cl)c(NC(=S)NCCCn2ccnc2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F20 compound treatment 759930.0 -984000.0 -4.82 897820.0 -883000.0 -3.92 1133830.0 -740140.37037037 -3.85784723509353 1198960.0 -616339.375 -2.97174841541846 -7.7818 -0.9862 2069976 Maybridge1_001010 FC(F)(F)c1ccc(Cl)c(NC(=S)NN=C2CCCCCC2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F21 compound treatment 1238560.0 -506000.0 -2.47 1426580.0 -355000.0 -1.57 1341720.0 -532250.37037037 -2.77425837302097 1355750.0 -459549.375 -2.21576810172608 -4.5185 -0.9813 2069977 Maybridge1_001011 CSc1cccc(NC(=S)/N=C/N(C)C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F22 compound treatment 1624770.0 -120000.0 -0.58 1766620.0 -14500.0 -0.06 1728890.0 -145080.37037037 -0.7562050769094 1735380.0 -79919.375 -0.385340099385153 -0.8953 -0.8669 2069978 Maybridge1_001012 Clc1ccc(OCOc2ccc(Cl)cc2Cl)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F23 mock treatment 1566300.0 -178000.0 -0.87 1869920.0 88800.0 0.39 1890010.0 16039.6296296299 0.0836036558681803 1829950.0 14650.625 0.0706396076490164 -0.1614 -0.1678 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 F24 mock treatment 1483390.0 -261000.0 -1.28 1921860.0 141000.0 0.62 1499620.0 -374350.37037037 -1.9512333053349 1710370.0 -104929.375 -0.505928578532077 -1.5548 -0.6304 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G01 compound treatment 1352610.0 -392000.0 -1.92 1449610.0 -331000.0 -1.47 1462930.0 -411040.37037037 -2.14247326564776 1299780.0 -515519.375 -2.48563364262386 -4.0074 -0.9835 2069979 Maybridge1_001013 O=c1s[nH]c2ccccc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G02 compound treatment 1554040.0 -190000.0 -0.93 1505870.0 -275000.0 -1.22 1669280.0 -204690.37037037 -1.06691137383636 1469310.0 -345989.375 -1.66822601088543 -2.4434 -0.9752 1483646 Maybridge1_001014 Fc1cccc2nc(oc(=O)c12)C(C3CCCC3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G03 compound treatment 1479080.0 -265000.0 -1.3 1745140.0 -36000.0 -0.16 1690590.0 -183380.37037037 -0.955836869768023 1646190.0 -169109.375 -0.815379541812748 -1.6143 -0.8902 1722347 Maybridge1_001015 COc1cc(cc(OC)c1OC)c2c(C#N)c(OC)[nH]c(=O)c2C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G04 compound treatment 1545320.0 -199000.0 -0.97 1645410.0 -136000.0 -0.6 1606310.0 -267660.37037037 -1.39513106042402 1507840.0 -307459.375 -1.48244935748556 -2.2265 -0.9534 1136768 Maybridge1_001016 Nc1ccc(Oc2ccc(Cl)cc2Cl)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G05 compound treatment 1617120.0 -127000.0 -0.62 1778370.0 -2730.0 -0.01 1751130.0 -122840.37037037 -0.640283116774262 1639360.0 -175939.375 -0.848311141675742 -1.0615 -0.8618 2069980 Maybridge1_001017 CC(C)NC(=O)N1CCN(CC1)c2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G06 compound treatment 1870790.0 126000.0 0.62 1796510.0 15400.0 0.07 1854350.0 -19620.3703703701 -0.102267616542746 1632450.0 -182849.375 -0.88162847038047 -0.1483 -0.1368 2069981 Maybridge1_001018 Cc1ccc(cc1)C(=O)CSC(=S)SC(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G07 compound treatment 1676800.0 -67500.0 -0.33 1606780.0 -174000.0 -0.77 1482750.0 -391220.37037037 -2.03916511592301 1561600.0 -253699.375 -1.22323957584067 -2.1829 -0.8655 2069982 Maybridge1_001019 FC(F)(F)c1cc(NC(=O)NC(=O)c2c(Cl)cccc2Cl)cc(c1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G08 compound treatment 1726130.0 -18200.0 -0.09 1761520.0 -19600.0 -0.09 1771040.0 -102930.37037037 -0.536505858397887 1446400.0 -368899.375 -1.77868910793685 -1.2455 -0.6689 2069983 Maybridge1_001020 [O-][N+](=O)c1ccc(Oc2c(Cl)cccc2Cl)c(Cl)c1Oc3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G09 compound treatment 1832960.0 88700.0 0.43 1697780.0 -83300.0 -0.37 1785340.0 -88630.3703703701 -0.461969705972866 1620120.0 -195179.375 -0.94107892811264 -0.6693 -0.561 1698854 Maybridge1_001021 Fc1cccc(F)c1C(=O)NC(=O)NCCc2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G10 compound treatment 1622600.0 -122000.0 -0.6 1702960.0 -78100.0 -0.35 1684160.0 -189810.37037037 -0.989352076767525 1564250.0 -251049.375 -1.21046230795825 -1.5709 -0.9195 2069984 Maybridge1_001022 FC(F)(F)c1ccc(OCc2ccccc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G11 compound treatment 1854880.0 111000.0 0.54 1738490.0 -42600.0 -0.19 1874310.0 339.629629629897 0.00177025775119912 1655890.0 -159409.375 -0.768609919752565 -0.2073 -0.2163 1033716 Maybridge1_001023 CC(=O)Nc1ccc(F)cc1F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G12 compound treatment 1654310.0 -90000.0 -0.44 1825390.0 44300.0 0.2 1807800.0 -66170.3703703701 -0.34490103580042 1628640.0 -186659.375 -0.899998806468026 -0.7444 -0.6907 2069985 Maybridge1_001024 [O-][N+](=O)c1cccnc1Sc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G13 compound treatment 1770990.0 26700.0 0.13 1780250.0 -847.0 0.0 1684160.0 -189810.37037037 -0.989352076767525 1612240.0 -203059.375 -0.979073219023386 -0.9208 -0.6586 2069986 Maybridge1_001025 CCOC(=O)CCC(C#N)(N1CCOCC1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G14 compound treatment 1727080.0 -17200.0 -0.08 1530720.0 -250000.0 -1.11 1737230.0 -136740.37037037 -0.712734341858723 1619360.0 -195939.375 -0.944743352109108 -1.426 -0.8776 2069987 Maybridge1_001026 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)N3CCCCC3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G15 compound treatment 1504400.0 -240000.0 -1.17 1450660.0 -330000.0 -1.47 1639890.0 -234080.37037037 -1.22010141018401 1496960.0 -318339.375 -1.53490847996131 -2.6972 -0.9935 1716717 Maybridge1_001027 Fc1cccc(Cl)c1C(=O)NC(=O)Nc2ccccc2N3CCCCC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G16 compound treatment 1710400.0 -33900.0 -0.17 1460480.0 -321000.0 -1.42 1849350.0 -24620.3703703701 -0.128329208299747 1733600.0 -81699.375 -0.393922566113723 -1.055 -0.7079 2069988 Maybridge1_001028 COc1ccccc1Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G17 compound treatment 1537760.0 -207000.0 -1.01 1660640.0 -120000.0 -0.53 1773030.0 -100940.37037037 -0.526133344878601 1627490.0 -187809.375 -0.905543658567945 -1.4883 -0.9599 2069989 Maybridge1_001029 Cc1nn(nc1C(=O)N)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G18 compound treatment 1660110.0 -84200.0 -0.41 1510780.0 -270000.0 -1.2 1801980.0 -71990.3703703701 -0.375236728605568 1579590.0 -235709.375 -1.13649880255586 -1.5612 -0.8955 2069990 Maybridge1_001030 N/C(=N\O)/c1ccc(cc1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G19 compound treatment 1439840.0 -304000.0 -1.49 1384840.0 -396000.0 -1.76 1487800.0 -386170.37037037 -2.01284290824844 1475330.0 -339969.375 -1.63919991554499 -3.4496 -0.9939 2069991 Maybridge1_001031 CSC1=NCCCN1C(=O)c2c(C)onc2c3c(F)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G20 compound treatment 1434910.0 -309000.0 -1.51 1723370.0 -57700.0 -0.26 1914610.0 40639.6296296299 0.211826687312622 1640270.0 -175029.375 -0.843923476101024 -1.201 -0.6805 1190516 Maybridge1_001032 COc1ccc(c2c(C)n[nH]c2C)c(c1)C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G21 compound treatment 1667290.0 -77000.0 -0.38 1701360.0 -79700.0 -0.35 1766440.0 -107530.37037037 -0.560482522814327 1680970.0 -134329.375 -0.647683927869125 -0.9693 -0.969 1072508 Maybridge1_001033 Brc1ccc(cc1)C(=O)CSCC(=O)c2ccc(Br)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G22 compound treatment 335870.0 -1410000.0 -6.89 387390.0 -1390000.0 -6.18 573220.0 -1300750.37037037 -6.77992502607193 546150.0 -1269149.375 -6.11934398006873 -12.986 -0.9986 2069992 Maybridge1_001034 CCC1(CC)N/C(=N/c2cc(Cl)cc(Cl)c2)/SC1=C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G23 mock treatment 1680750.0 -63500.0 -0.31 1497300.0 -284000.0 -1.26 1588570.0 -285400.37037037 -1.48759758797786 1824080.0 8780.625 0.0423367538868236 -1.5074 -0.7637 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 G24 mock treatment 1773610.0 29300.0 0.14 1754030.0 -27100.0 -0.12 1902470.0 28499.6296296299 0.148549142526625 1819090.0 3790.625 0.0182769173836988 0.0951 0.397 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H01 compound treatment 1436640.0 -308000.0 -1.51 1524480.0 -257000.0 -1.14 1585020.0 -288950.37037037 -1.50610131812533 1320800.0 -494499.375 -2.38428338945839 -3.267 -0.9628 1541940 Maybridge1_001035 COc1ccc(OC)c(c1)S(=O)(=O)N2CCc3cc(OC)c(OC)cc3C2C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H02 compound treatment 1585360.0 -159000.0 -0.78 1611360.0 -170000.0 -0.75 1776850.0 -97120.3703703701 -0.506222288776252 1502480.0 -312819.375 -1.5082931898817 -1.7725 -0.9211 2069993 Maybridge1_001036 Cc1onc(c1C(=O)Nc2cc(C)c(C)cc2[N+](=O)[O-])c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H03 compound treatment 900540.0 -844000.0 -4.13 1150930.0 -630000.0 -2.79 1198030.0 -675940.37037037 -3.52321639693364 977320.0 -837979.375 -4.04041017144101 -7.2436 -0.9894 2069994 Maybridge1_001037 COc1ccccc1Oc2ccc(cc2NC(=O)NC(=O)c3ccccc3F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H04 compound treatment 1468280.0 -276000.0 -1.35 1582420.0 -199000.0 -0.88 1615390.0 -258580.37037037 -1.34780320979331 1464580.0 -350719.375 -1.69103222865293 -2.6353 -0.9769 1249841 Maybridge1_001038 Cc1ccc(cc1)S(=O)(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H05 compound treatment 1586160.0 -158000.0 -0.77 1626400.0 -155000.0 -0.69 1820970.0 -53000.3703703701 -0.276254803112481 1634040.0 -181259.375 -0.873962109651018 -1.3051 -0.9444 1681763 Maybridge1_001039 Clc1ccccc1C(=O)NC(=O)N2CCSCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H06 compound treatment 1509820.0 -234000.0 -1.15 1405860.0 -375000.0 -1.66 1629170.0 -244800.37037037 -1.27597746291102 1505030.0 -310269.375 -1.49599808305144 -2.7917 -0.99 2069995 Maybridge1_001040 COc1cc(OC)cc(/N=C\2/NC(C)(C)C(=C)S2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H07 compound treatment 1594080.0 -150000.0 -0.74 1834720.0 53600.0 0.24 1852330.0 -21640.3703703701 -0.112796499612575 1560800.0 -254499.375 -1.227096864258 -0.9186 -0.6316 1713948 Maybridge1_001041 Cc1cc(ccc1Cl)C(=O)CN2C(=O)c3ccccc3C2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H08 compound treatment 1660510.0 -83800.0 -0.41 1538980.0 -242000.0 -1.07 1732070.0 -141900.37037037 -0.739629904551948 1508130.0 -307169.375 -1.48105109043427 -1.8522 -0.9191 2069996 Maybridge1_001042 CC(=O)c1cc(Br)ccc1OC(=O)c2c(C)onc2c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H09 compound treatment 1654080.0 -90200.0 -0.44 1569230.0 -212000.0 -0.94 1707140.0 -166830.37037037 -0.869573001052352 1435600.0 -379699.375 -1.83076250157087 -2.0407 -0.8962 2069997 Maybridge1_001043 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1Sc2nc(n[nH]2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H10 compound treatment 1594580.0 -150000.0 -0.73 1621920.0 -159000.0 -0.71 1628800.0 -245170.37037037 -1.27790602070103 1500490.0 -314809.375 -1.51788819481982 -2.1172 -0.9495 2069998 Maybridge1_001044 Cc1ccc(cc1)S(=O)(=O)Nc2ccc(F)cc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H11 compound treatment 1512720.0 -232000.0 -1.13 1366470.0 -415000.0 -1.84 1612010.0 -261960.37037037 -1.36542084582104 1410560.0 -404739.375 -1.95149562903345 -3.1444 -0.978 1107935 Maybridge1_001045 CC(=O)Nc1ccc(cc1)C2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H12 compound treatment 973120.0 -771000.0 -3.77 944040.0 -837000.0 -3.71 966030.0 -907940.37037037 -4.73247425445846 1037200.0 -778099.375 -3.75169213340352 -7.985 -0.9943 1300335 Maybridge1_001046 Cc1cc(Oc2cc(C)c(Cl)c(C)c2)c3ccccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H13 compound treatment 1695060.0 -49200.0 -0.24 1352050.0 -429000.0 -1.9 1708180.0 -165790.37037037 -0.864152189966896 1604510.0 -210789.375 -1.01634426835588 -2.0121 -0.8612 2069999 Maybridge1_001047 Clc1ccc(SCC(=O)Nc2ccc(Br)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H14 compound treatment 1370290.0 -374000.0 -1.83 1089700.0 -691000.0 -3.07 1087760.0 -786210.37037037 -4.09797874154253 1378370.0 -436929.375 -2.10670327172595 -5.5505 -0.9521 1404813 Maybridge1_001048 Fc1ccc(cc1)C(=O)On2c(nc3ccccc3c2=O)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H15 compound treatment 1187220.0 -557000.0 -2.73 1339420.0 -442000.0 -1.96 1384990.0 -488980.37037037 -2.54872135795589 1220550.0 -594749.375 -2.86764984425564 -5.0506 -0.9907 2070000 Maybridge1_001049 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)NC(=N)c3ccncc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H16 compound treatment 1331630.0 -413000.0 -2.02 1466880.0 -314000.0 -1.39 1407410.0 -466560.37037037 -2.4318611805175 1301280.0 -514019.375 -2.47840122684136 -4.1615 -0.9788 1719758 Maybridge1_001050 Clc1cccc(Cl)c1CSc2ncc3ccccn23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H17 compound treatment 1545610.0 -199000.0 -0.97 1525020.0 -256000.0 -1.14 1824960.0 -49010.3703703701 -0.255457652890395 1637870.0 -177429.375 -0.855495341353028 -1.6094 -0.9243 2070001 Maybridge1_001051 [O-][N+](=O)c1cc(ccc1N2CCN(CC2)C(=O)NC(=O)c3ccccc3Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H18 compound treatment 1243520.0 -501000.0 -2.45 1239950.0 -541000.0 -2.4 1116120.0 -757850.37037037 -3.95015739309682 1112520.0 -702779.375 -3.38852842891146 -6.0945 -0.9778 2070002 Maybridge1_001052 FC(F)(F)C(=O)c1nc(SCc2ccc(Cl)cc2)n3ccccc13 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H19 compound treatment 1684350.0 -59900.0 -0.29 1371580.0 -410000.0 -1.82 1646180.0 -227790.37037037 -1.1873159277537 1572320.0 -242979.375 -1.17155191104838 -2.2342 -0.8997 2070003 Maybridge1_001053 FC(F)(F)c1cccc(NC(=S)Nc2ccccn2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H20 compound treatment 1307430.0 -437000.0 -2.14 1368750.0 -412000.0 -1.83 1643560.0 -230410.37037037 -1.20097220183437 1546150.0 -269149.375 -1.29773345840044 -3.2326 -0.9729 2070004 Maybridge1_001054 Cc1ccc(NC(=S)NN=C2CCCCCC2)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H21 compound treatment 1551410.0 -193000.0 -0.94 1445240.0 -336000.0 -1.49 1771970.0 -102000.37037037 -0.531658402331085 1731620.0 -83679.375 -0.403469354946626 -1.6842 -0.8933 1593023 Maybridge1_001055 CC(=O)Nc1cc(=O)oc2ccc(NC(=O)c3ccc(F)cc3)cc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H22 compound treatment 1292520.0 -452000.0 -2.21 1685550.0 -95500.0 -0.42 1561250.0 -312720.37037037 -1.62999812533811 1535520.0 -279779.375 -1.34898717824578 -2.8067 -0.9085 2070005 Maybridge1_001056 Cc1cc(OCOc2ccc(Cl)c(C)c2)ccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H23 mock treatment 1549480.0 -195000.0 -0.95 1767960.0 -13100.0 -0.06 1918690.0 44719.6296296299 0.233092946186335 1815010.0 -289.375 -0.00139525354470776 -0.3899 -0.3966 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 H24 mock treatment 1664280.0 -80000.0 -0.39 1920370.0 139000.0 0.62 1870790.0 -3180.3703703701 -0.0165771028457291 1862210.0 46910.625 0.226184763078035 0.2178 0.2845 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I01 compound treatment 1447800.0 -296000.0 -1.45 1477780.0 -303000.0 -1.35 1517180.0 -356790.37037037 -1.85970499508431 1417720.0 -397579.375 -1.9169728976983 -3.2864 -0.9887 1094153 Maybridge1_001057 NNC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I02 compound treatment 1695800.0 -48500.0 -0.24 1717780.0 -63300.0 -0.28 1754240.0 -119730.37037037 -0.624072806701408 1505950.0 -309349.375 -1.49156220137151 -1.3169 -0.7942 2070006 Maybridge1_001058 Cc1onc(c1c2nc3cccc(F)c3c(=O)o2)c4c(Cl)cccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I03 compound treatment 1780160.0 35900.0 0.18 1746990.0 -34100.0 -0.15 1480340.0 -393630.37037037 -2.05172680314989 1396010.0 -419289.375 -2.02165006212372 -2.0246 -0.7006 2070007 Maybridge1_001059 Cc1cc(=O)cc(C)n1NC(=O)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I04 compound treatment 1721280.0 -23000.0 -0.11 1659650.0 -121000.0 -0.54 1719230.0 -154740.37037037 -0.806556072183925 1529980.0 -285319.375 -1.37569890053582 -1.4167 -0.8398 1492347 Maybridge1_001060 Nc1ccc(Oc2c(Cl)cccc2Cl)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I05 compound treatment 1357170.0 -387000.0 -1.89 1700860.0 -80200.0 -0.36 1800070.0 -73900.3703703701 -0.385192256656743 1619680.0 -195619.375 -0.943200436742174 -1.7893 -0.8207 2070008 Maybridge1_001061 Clc1ccc(cc1)C(C#N)N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I06 compound treatment 1473540.0 -271000.0 -1.32 1543970.0 -237000.0 -1.05 1597370.0 -276600.37037037 -1.44172918648554 1437760.0 -377539.375 -1.82034782284407 -2.8193 -0.9813 2070009 Maybridge1_001062 CC(C)(C)SC(=S)SCC(=O)c1ccc(cc1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I07 compound treatment 1660120.0 -84200.0 -0.41 1775000.0 -6100.0 -0.03 1711520.0 -162450.37037037 -0.846743046673219 1584380.0 -230919.375 -1.11340328815706 -1.1996 -0.8225 2070010 Maybridge1_001063 Clc1cccc(Cl)c1C(=O)NC(=O)NCc2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I08 compound treatment 1804170.0 59900.0 0.29 1721640.0 -59500.0 -0.26 1763410.0 -110560.37037037 -0.576275847419069 1629300.0 -185999.375 -0.896816543523725 -0.7219 -0.6352 2070011 Maybridge1_001064 CC(C=C)N1C(=O)c2ccccc2C1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I09 compound treatment 1662050.0 -82200.0 -0.4 1655960.0 -125000.0 -0.55 1719840.0 -154130.37037037 -0.803376557989571 1709540.0 -105759.375 -0.509930515265062 -1.1354 -0.9681 2070012 Maybridge1_001065 [O-][N+](=O)c1ccc(cc1)C(=O)NCCc2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I10 compound treatment 1205660.0 -539000.0 -2.64 1136610.0 -644000.0 -2.86 1101460.0 -772510.37037037 -4.02656998012835 1125380.0 -689919.375 -3.32652251760281 -6.4235 -0.9865 1648615 Maybridge1_001066 CC1CN(Cc2cc(C)c(O)c(C)c2)CC(C)O1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I11 compound treatment 1716880.0 -27400.0 -0.13 1613250.0 -168000.0 -0.74 1711790.0 -162180.37037037 -0.845335720718341 1619000.0 -196299.375 -0.946479131896908 -1.3352 -0.9038 2070013 Maybridge1_001067 Clc1ccc(SCc2ccc(cc2)c3nc4ccccc4[nH]3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I12 compound treatment 1702520.0 -41800.0 -0.2 1908740.0 128000.0 0.57 1847450.0 -26520.3703703701 -0.138232613167407 1571360.0 -243939.375 -1.17618065714919 -0.4764 -0.3586 1024512 Maybridge1_001068 COc1cc2CCN=C(C)c2cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I13 compound treatment 1582880.0 -161000.0 -0.79 1747160.0 -33900.0 -0.15 1854660.0 -19310.3703703701 -0.100651797853812 1589210.0 -226089.375 -1.09011490933741 -1.0656 -0.7845 1715965 Maybridge1_001069 Cc1onc(c1C(=O)NCCS(=O)(=O)c2ccc(C)cc2)c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I14 compound treatment 1742620.0 -1680.0 -0.01 1545670.0 -235000.0 -1.04 1737940.0 -136030.37037037 -0.709033595829229 1696480.0 -118819.375 -0.57290074867805 -1.1671 -0.8421 2070014 Maybridge1_001070 NCC(=O)c1cccc(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I15 compound treatment 1583440.0 -161000.0 -0.79 1545190.0 -236000.0 -1.05 1760330.0 -113640.37037037 -0.592329787941382 1493760.0 -321539.375 -1.55033763363064 -1.988 -0.9404 1230300 Maybridge1_001071 Nc1c(Cl)cc(cc1Cl)C(=O)Nc2cc(Cl)cc(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I16 compound treatment 1553870.0 -190000.0 -0.93 1444410.0 -337000.0 -1.49 1725240.0 -148730.37037037 -0.77523003889201 1529450.0 -285849.375 -1.3782543541123 -2.2892 -0.9675 2070015 Maybridge1_001072 Clc1ccc(COC(=O)c2cccs2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I17 compound treatment 1331780.0 -413000.0 -2.02 1334290.0 -447000.0 -1.98 1676320.0 -197650.37037037 -1.0302166526425 1611520.0 -203779.375 -0.982544778598987 -3.0064 -0.9494 2070016 Maybridge1_001073 Cc1nn(nc1C(=O)NNC(=S)Nc2ccc(C)c(C)c2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I18 compound treatment 1485480.0 -259000.0 -1.27 1800160.0 19100.0 0.08 1744160.0 -129810.37037037 -0.676612975683521 1736530.0 -78769.375 -0.379795247285235 -1.1192 -0.7523 2070017 Maybridge1_001074 Fc1ccc(NC(=O)CS(=O)(=O)Cc2c(F)cccc2Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I19 compound treatment 1337920.0 -406000.0 -1.99 1772380.0 -8720.0 -0.04 1846470.0 -27500.3703703701 -0.143340685151779 1594080.0 -221219.375 -1.06663366609688 -1.6186 -0.7157 2070018 Maybridge1_001075 CSC1=NCCCN1C(=O)c2c(C)onc2c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I20 compound treatment 1705810.0 -38500.0 -0.19 1407460.0 -374000.0 -1.66 1836550.0 -37420.3703703701 -0.195046883197668 1676990.0 -138309.375 -0.666873937745365 -1.3536 -0.7493 1565983 Maybridge1_001076 COc1ccc(c2c(C)nn(C)c2C)c(c1)C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I21 compound treatment 1346740.0 -398000.0 -1.95 1403380.0 -378000.0 -1.68 1793140.0 -80830.3703703701 -0.421313622831945 1625170.0 -190129.375 -0.916729794978215 -2.4793 -0.8988 1063570 Maybridge1_001077 [O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I22 compound treatment 1783520.0 39200.0 0.19 1551010.0 -230000.0 -1.02 1874100.0 129.629629629897 6.75670897405107E-4 1736650.0 -78649.375 -0.379216654022635 -0.6035 -0.546 2070019 Maybridge1_001078 Nc1ccccc1C(=O)NCCCn2ccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I23 mock treatment 1505920.0 -238000.0 -1.17 1581840.0 -199000.0 -0.88 1955790.0 81819.6296296299 0.426469957023277 1799200.0 -16099.375 -0.0776249158922834 -0.8506 -0.5573 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 I24 mock treatment 1793760.0 49500.0 0.24 1858960.0 77900.0 0.35 1802190.0 -71780.3703703701 -0.374142141751774 1876080.0 60780.625 0.293060501013574 0.2531 0.3984 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J01 compound treatment 1689550.0 -54700.0 -0.27 1734130.0 -47000.0 -0.21 1798240.0 -75730.3703703701 -0.394730799239805 1545990.0 -269309.375 -1.29850491608391 -1.0847 -0.7754 2070020 Maybridge1_001079 CC1CN(CC(C)O1)C2=NCCN2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J02 compound treatment 1503170.0 -241000.0 -1.18 1724870.0 -56200.0 -0.25 1768090.0 -105880.37037037 -0.551882197534517 1513230.0 -302069.375 -1.45646087677376 -1.7188 -0.8726 2070021 Maybridge1_001080 Fc1ccc(OC(=O)NC(=O)c2c(Cl)cccc2Cl)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J03 compound treatment 1711780.0 -32500.0 -0.16 1657310.0 -124000.0 -0.55 1635360.0 -238610.37037037 -1.24371321231585 1549080.0 -266219.375 -1.28360613957196 -1.6177 -0.8621 2070022 Maybridge1_001081 COc1ccccc1Oc2ccc(cc2NC(=O)NC(=O)c3c(F)cccc3Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J04 compound treatment 1362750.0 -382000.0 -1.87 1458940.0 -322000.0 -1.43 1399090.0 -474880.37037037 -2.47522766920115 1315580.0 -499719.375 -2.4094521963815 -4.0902 -0.9789 1481239 Maybridge1_001082 COc1ccc(cc1OC)S(=O)(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J05 compound treatment 583320.0 -1160000.0 -5.68 491680.0 -1290000.0 -5.72 839650.0 -1034320.37037037 -5.3912070477084 820280.0 -995019.375 -4.7975958877638 -10.7941 -0.9977 2070023 Maybridge1_001083 Cc1cc(Oc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])c3c(Cl)ccc(C)c3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J06 compound treatment 1717600.0 -26700.0 -0.13 1723680.0 -57400.0 -0.25 1764960.0 -109010.37037037 -0.568196753974399 1502370.0 -312929.375 -1.50882356703908 -1.2312 -0.7519 1920653 Maybridge1_001084 Clc1ccc(/C=C\2/N=C(OC2=O)c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J07 compound treatment 1789360.0 45100.0 0.22 1664820.0 -116000.0 -0.52 1808610.0 -65360.3703703701 -0.340679057935786 1539840.0 -275459.375 -1.32815782079217 -0.982 -0.6629 1043741 Maybridge1_001085 CSc1ccc(Br)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J08 compound treatment 1626140.0 -118000.0 -0.58 1656330.0 -125000.0 -0.55 1655840.0 -218130.37037037 -1.13696493247918 1393570.0 -421729.375 -2.03341479179659 -2.1509 -0.8732 2070024 Maybridge1_001086 CC(=O)c1cc(Cl)cc(Cl)c1OC(=O)c2c(C)onc2c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J09 compound treatment 1098880.0 -645000.0 -3.16 1090650.0 -690000.0 -3.06 990900.0 -883070.37037037 -4.60284389705914 962910.0 -852389.375 -4.10988957905825 -7.4665 -0.9853 2070025 Maybridge1_001087 Clc1c(sc2ccccc12)C(=O)N/N=C/c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J10 compound treatment 1598480.0 -146000.0 -0.71 1501600.0 -279000.0 -1.24 1456430.0 -417540.37037037 -2.17635333493186 1194400.0 -620899.375 -2.99373495939726 -3.5616 -0.8976 1296994 Maybridge1_001088 Cc1cc(Oc2ccnc3cc(Cl)ccc23)cc(C)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J11 compound treatment 1661920.0 -82400.0 -0.4 1709940.0 -71200.0 -0.32 1732000.0 -141970.37037037 -0.739994766836546 1459040.0 -356259.375 -1.71774395094297 -1.5882 -0.819 2070026 Maybridge1_001089 Cc1cc(ccc1Cl)C(=O)CC(Sc2ccccc2N)c3c(F)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J12 compound treatment 744640.0 -1000000.0 -4.89 1061130.0 -720000.0 -3.19 990920.0 -883050.37037037 -4.60273965069211 832280.0 -983019.375 -4.73973656150378 -8.7135 -0.988 1724700 Maybridge1_001090 Cc1cc(Oc2ccc(Cl)c(C)c2)c3ccccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J13 compound treatment 1410450.0 -334000.0 -1.63 1463110.0 -318000.0 -1.41 1783900.0 -90070.3703703701 -0.469475444398882 1538760.0 -276539.375 -1.33336516015557 -2.4233 -0.9393 2070027 Maybridge1_001091 Cc1ccc(SCC(=O)Nc2ccc(Br)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J14 compound treatment 1382120.0 -362000.0 -1.77 1433180.0 -348000.0 -1.54 1472830.0 -401140.37037037 -2.0908713139689 1506000.0 -309299.375 -1.49132112084542 -3.4487 -0.9907 2070028 Maybridge1_001092 COC(=O)c1sc2cc(Cl)ccc2c1O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J15 compound treatment 1531620.0 -213000.0 -1.04 1446350.0 -335000.0 -1.48 1598530.0 -275440.37037037 -1.43568289719791 1548530.0 -266769.375 -1.28625802535887 -2.6236 -0.9914 2070029 Maybridge1_001093 CC(=N)NS(=O)(=O)c1cc(Cl)c(Oc2ccc(cc2)[N+](=O)[O-])c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J16 compound treatment 1511040.0 -233000.0 -1.14 1403240.0 -378000.0 -1.68 1802470.0 -71500.3703703701 -0.372682692613382 1708070.0 -107229.375 -0.517018282731914 -1.8534 -0.8721 1006327 Maybridge1_001094 CCOC(=O)c1cc2ccccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J17 compound treatment 1703520.0 -40800.0 -0.2 1517880.0 -263000.0 -1.17 1848740.0 -25230.3703703701 -0.131508722494101 1741480.0 -73819.375 -0.355928275202977 -0.9271 -0.7456 2070030 Maybridge1_001095 Cc1ccc(SCC(=O)N2CCN(CC2)c3ccc(cc3[N+](=O)[O-])C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J18 compound treatment 1114480.0 -630000.0 -3.08 1285700.0 -495000.0 -2.2 1377520.0 -496450.37037037 -2.58765737604084 1371150.0 -444149.375 -2.14151529969239 -5.004 -0.9889 2070031 Maybridge1_001096 CC(=NNC(=S)Nc1ccc(C)cc1C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J19 compound treatment 1610950.0 -133000.0 -0.65 1606600.0 -174000.0 -0.77 1833970.0 -40000.3703703701 -0.20849466454428 1681440.0 -133859.375 -0.645417770923941 -1.1401 -0.9357 2070032 Maybridge1_001097 C/C(=N\Nc1c(Cl)cc(Cl)cc1Cl)/C=N/OCc2c(F)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J20 compound treatment 1474050.0 -270000.0 -1.32 1358410.0 -423000.0 -1.87 1795060.0 -78910.3703703701 -0.411305971597257 1687540.0 -127759.375 -0.616005946741764 -2.1121 -0.8762 2070033 Maybridge1_001098 Cc1cc(C)c(NC(=S)NN=C2CCCCCC2)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J21 compound treatment 1649650.0 -94600.0 -0.46 1284100.0 -497000.0 -2.2 1624450.0 -249520.37037037 -1.30057960552962 1667430.0 -147869.375 -0.712968534332513 -2.3404 -0.8679 1504079 Maybridge1_001099 COc1ccc(cc1OC)S(=O)(=O)Nc2ccc3oc(=O)c(NC(=O)C)cc3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J22 compound treatment 1451410.0 -293000.0 -1.43 1611480.0 -170000.0 -0.75 1556510.0 -317460.37037037 -1.65470451432375 1483040.0 -332259.375 -1.60202529842293 -2.7211 -0.9666 2070034 Maybridge1_001100 CS/C(=N/N=C/c1c(Cl)cccc1Cl)/N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J23 mock treatment 1704640.0 -39700.0 -0.19 1835880.0 54800.0 0.24 1918920.0 44949.6296296299 0.234291779407157 1683380.0 -131919.375 -0.636063846511904 -0.1764 -0.2366 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 J24 mock treatment 1728480.0 -15800.0 -0.08 1879430.0 98300.0 0.44 1783070.0 -90900.3703703701 -0.473801668630544 1809600.0 -5699.375 -0.0274801664669332 -0.0713 -0.1098 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K01 compound treatment 785210.0 -959000.0 -4.69 828290.0 -953000.0 -4.23 842330.0 -1031640.37037037 -5.37723803452665 770290.0 -1045009.375 -5.038628197742 -9.6673 -0.9961 2070035 Maybridge1_001101 Cc1cc(cc([N+](=O)[O-])c1Sc2ccc(Cl)cc2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K02 compound treatment 1749520.0 5220.0 0.03 1726110.0 -55000.0 -0.24 1673560.0 -200410.37037037 -1.04460265129237 1599520.0 -215779.375 -1.04040410485901 -1.1517 -0.7706 2070036 Maybridge1_001102 Fc1cccc2nc(oc(=O)c12)c3cccc(c3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K03 compound treatment 1737760.0 -6540.0 -0.03 1768840.0 -12300.0 -0.05 1619140.0 -254830.37037037 -1.32825701597556 1494470.0 -320829.375 -1.54691429016026 -1.4808 -0.7259 2070037 Maybridge1_001103 CC(=O)c1cc2cc(ccc2o1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K04 compound treatment 1195750.0 -549000.0 -2.68 1496910.0 -284000.0 -1.26 1518360.0 -355610.37037037 -1.85355445942966 1023040.0 -792259.375 -3.81996613839034 -4.809 -0.9286 1359192 Maybridge1_001104 Cc1cc(Oc2ccc(N)cn2)cc(C)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K05 compound treatment 1732030.0 -12300.0 -0.06 1750400.0 -30700.0 -0.14 1860670.0 -13300.3703703701 -0.0693257645618979 1575880.0 -239419.375 -1.15438697759125 -0.7099 -0.6089 1364082 Maybridge1_001105 COc1cc(cc(OC)c1OC)C(C#N)N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K06 compound treatment 1808160.0 63900.0 0.31 1922290.0 141000.0 0.63 1802580.0 -71390.3703703701 -0.372109337594728 1610890.0 -204409.375 -0.985582393227638 -0.2095 -0.1657 2070038 Maybridge1_001106 CC(C)(C)SC(=S)SCC(=O)c1ccc(Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K07 compound treatment 1656200.0 -88100.0 -0.43 1781460.0 363.0 0.0 1780320.0 -93650.3703703701 -0.488135544096894 1640480.0 -174819.375 -0.842910937891474 -0.8803 -0.8264 1127157 Maybridge1_001107 Nc1ccc(Cl)cc1C(=O)NCc2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K08 compound treatment 1580160.0 -164000.0 -0.8 1675080.0 -106000.0 -0.47 1809070.0 -64900.3703703701 -0.338281391494142 1643620.0 -171679.375 -0.827771080853435 -1.2197 -0.945 2070039 Maybridge1_001108 CN(C)c1cc(N2CCCC2)c(F)cc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K09 compound treatment 1854050.0 110000.0 0.54 1685730.0 -95400.0 -0.42 1870400.0 -3570.3703703701 -0.0186099070027752 1685380.0 -129919.375 -0.626420625468568 -0.2655 -0.2862 1208334 Maybridge1_001109 Clc1ccc(cc1Cl)C(=O)NCCc2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K10 compound treatment 1198750.0 -546000.0 -2.67 1234560.0 -547000.0 -2.42 1277920.0 -596050.37037037 -3.10680428384029 1196000.0 -619299.375 -2.98602038256259 -5.5931 -0.9954 1428930 Maybridge1_001110 CC1CC(C)CN(Cc2cc(C)c(O)c(C)c2)C1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K11 compound treatment 1709480.0 -34800.0 -0.17 1928170.0 147000.0 0.65 1753460.0 -120510.37037037 -0.6281384150155 1621470.0 -193829.375 -0.934569753908388 -0.5404 -0.4118 2070040 Maybridge1_001111 COc1ccc(C(C(=O)C)C(=O)C)c(c1)C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K12 compound treatment 1436100.0 -308000.0 -1.51 1614240.0 -167000.0 -0.74 1824890.0 -49080.3703703701 -0.255822515174993 1663160.0 -152139.375 -0.733556811260037 -1.6187 -0.8746 2070041 Maybridge1_001112 Nc1cccc(NC=C(C#N)C#N)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K13 compound treatment 1861780.0 117000.0 0.57 1739640.0 -41500.0 -0.18 1775680.0 -98290.3703703701 -0.51232070124739 1740590.0 -74709.375 -0.360219508567262 -0.2408 -0.2768 1667067 Maybridge1_001113 Cc1onc(c1C(=O)NCC(=O)NN)c2c(Cl)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K14 compound treatment 1483090.0 -261000.0 -1.28 1590240.0 -191000.0 -0.85 1786020.0 -87950.3703703701 -0.458425329493914 1681870.0 -133429.375 -0.643344478399623 -1.6132 -0.9354 1019894 Maybridge1_001114 NCC(=O)c1ccc(Br)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K15 compound treatment 1265940.0 -478000.0 -2.34 1414940.0 -366000.0 -1.62 1516360.0 -357610.37037037 -1.86397909613246 1365810.0 -449489.375 -2.1672626998781 -3.9979 -0.9906 2070042 Maybridge1_001115 Cc1nn(nc1C(=O)Nc2nnc(s2)C(F)(F)F)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K16 compound treatment 1228260.0 -516000.0 -2.53 1330720.0 -450000.0 -2.0 1621240.0 -252730.37037037 -1.31731114743762 1487420.0 -327879.375 -1.58090664433802 -3.7104 -0.971 2070043 Maybridge1_001116 Fc1ccc(NC(=O)CSCc2ccc(Cl)c(Cl)c2)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K17 compound treatment 1165120.0 -579000.0 -2.83 1277830.0 -503000.0 -2.23 1240680.0 -633290.37037037 -3.30091101924643 1260990.0 -554309.375 -2.67266391475937 -5.5198 -0.9905 2070044 Maybridge1_001117 Cc1nn(nc1C(=O)NNC(=S)Nc2ccc(Cl)cc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K18 compound treatment 1246950.0 -497000.0 -2.43 1634320.0 -147000.0 -0.65 1639800.0 -234170.37037037 -1.22057051883563 1546420.0 -268879.375 -1.29643162355959 -2.8008 -0.9079 2070045 Maybridge1_001118 N/C(=N\OC(=O)c1cccs1)/c2ccc(cc2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K19 compound treatment 1329510.0 -415000.0 -2.03 1520800.0 -260000.0 -1.15 1563540.0 -310430.37037037 -1.6180619163134 1524040.0 -291259.375 -1.40433926703453 -3.1032 -0.9792 1104645 Maybridge1_001119 Nc1ccccc1C(=O)NCCc2c[nH]c3ccccc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K20 compound treatment 1503090.0 -241000.0 -1.18 1747040.0 -34100.0 -0.15 1760400.0 -113570.37037037 -0.591964925656784 1618680.0 -196619.375 -0.948022047263842 -1.4357 -0.8794 1573183 Maybridge1_001120 Cc1onc(c1C(=O)Oc2ccc(F)cc2Cl)c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K21 compound treatment 1234800.0 -509000.0 -2.49 1405510.0 -376000.0 -1.67 1438410.0 -435560.37037037 -2.27027931162409 1497120.0 -318179.375 -1.53413702227784 -3.9816 -0.9803 2070046 Maybridge1_001121 [O-][N+](=O)c1ccc(Oc2c(Cl)cccc2Cl)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K22 compound treatment 1855680.0 111000.0 0.55 1595410.0 -186000.0 -0.82 1858510.0 -15460.3703703701 -0.0805843722009221 1715080.0 -100219.375 -0.48321879297502 -0.4211 -0.382 1010836 Maybridge1_001122 CCOC(=O)c1cnc(S)nc1N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K23 mock treatment 1574320.0 -170000.0 -0.83 1748500.0 -32600.0 -0.14 1836800.0 -37170.3703703701 -0.193743803609818 1835540.0 20240.625 0.0975924104651422 -0.5362 -0.6152 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 K24 mock treatment 1806560.0 62300.0 0.3 1891390.0 110000.0 0.49 1905650.0 31679.6296296299 0.165124314884078 1858660.0 43360.625 0.209068045726113 0.584 0.9199 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L01 compound treatment 1773670.0 29400.0 0.14 1740100.0 -41000.0 -0.18 2126520.0 252549.62962963 1.31636906915781 1555750.0 -259549.375 -1.25144599739243 0.0134 0.0073 1703714 Maybridge1_001123 Cc1cccc(c1)c2nc3cccc(F)c3c(=O)o2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L02 compound treatment 1761620.0 17300.0 0.08 1688770.0 -92300.0 -0.41 1501780.0 -372190.37037037 -1.93997469769587 1591450.0 -223849.375 -1.07931450176887 -1.672 -0.7401 2070047 Maybridge1_001124 COc1ccc([N+](=O)[O-])c(OC)c1C(=O)Nc2ccc(F)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L03 compound treatment 1532410.0 -212000.0 -1.04 1735520.0 -45600.0 -0.2 1363360.0 -510610.37037037 -2.66146380389667 1528370.0 -286929.375 -1.38346169347571 -2.642 -0.8308 2070048 Maybridge1_001125 [O-][N+](=O)c1cccnc1Sc2ncc3ccccn23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L04 compound treatment 1303270.0 -441000.0 -2.16 1642400.0 -139000.0 -0.62 1586580.0 -287390.37037037 -1.49797010149714 1553990.0 -261309.375 -1.25993203191056 -2.7656 -0.9287 1355972 Maybridge1_001126 Clc1ccc(cc1)S(=O)(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L05 compound treatment 1508190.0 -236000.0 -1.16 1486560.0 -295000.0 -1.31 1584560.0 -289410.37037037 -1.50849898456697 1394370.0 -420929.375 -2.02955750337926 -2.9998 -0.9766 2070049 Maybridge1_001127 Cc1cc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)c3cc(F)ccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L06 compound treatment 1691840.0 -52500.0 -0.26 1639270.0 -142000.0 -0.63 1707940.0 -166030.37037037 -0.865403146371232 1568000.0 -247299.375 -1.19238126850199 -1.4717 -0.9071 1558904 Maybridge1_001128 Nc1ccccc1C(=O)NCCc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L07 compound treatment 1717250.0 -27000.0 -0.13 1721370.0 -59700.0 -0.26 1768490.0 -105480.37037037 -0.549797270193957 1632800.0 -182499.375 -0.879940906697886 -0.9135 -0.8466 1540934 Maybridge1_001129 COc1ccc2N(CCCc2c1)C(=O)NC(=O)c3c(F)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L08 compound treatment 1695320.0 -49000.0 -0.24 1715450.0 -65600.0 -0.29 1640850.0 -233120.37037037 -1.21509758456666 1459950.0 -355349.375 -1.71335628536825 -1.7296 -0.8105 2070050 Maybridge1_001130 CC(=O)c1cc(F)ccc1OC(=O)c2c(C)onc2c3c(Cl)cccc3Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L09 compound treatment 1833120.0 88800.0 0.43 1738560.0 -42500.0 -0.19 1828380.0 -45590.3703703701 -0.237631524128606 1632210.0 -183089.375 -0.88278565690567 -0.4372 -0.4246 2070051 Maybridge1_001131 CCOC(=O)CNC(=O)c1c(F)cccc1F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L10 compound treatment 1554690.0 -190000.0 -0.93 1596000.0 -185000.0 -0.82 1588130.0 -285840.37037037 -1.48989100805247 1527060.0 -288239.375 -1.38977800325909 -2.3142 -0.9705 2070052 Maybridge1_001132 COc1ccc(cc1CSc2nc3cc(ccc3[nH]2)C(F)(F)F)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L11 compound treatment 1756340.0 12000.0 0.06 1923770.0 143000.0 0.63 1818290.0 -55680.3703703701 -0.290223816294233 1659060.0 -156239.375 -0.753325414398877 -0.176 -0.1713 2070053 Maybridge1_001133 Cc1cc(ccc1Cl)C2=Nc3ccccc3SC(C2)c4c(F)cccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L12 compound treatment 1255620.0 -489000.0 -2.39 1166670.0 -614000.0 -2.72 1212660.0 -661310.37037037 -3.44696017945266 1118010.0 -697289.375 -3.3620577871475 -5.9626 -0.9893 1583726 Maybridge1_001134 Cc1cc(Oc2ccc(Cl)cc2)c3ccccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L13 compound treatment 1642720.0 -102000.0 -0.5 1663520.0 -118000.0 -0.52 1523810.0 -350160.37037037 -1.82514732441453 1455780.0 -359519.375 -1.73346240124361 -2.2886 -0.8741 2070054 Maybridge1_001135 Brc1ccc(NC(=O)CSc2ncccn2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L14 compound treatment 1649440.0 -94900.0 -0.46 1405600.0 -375000.0 -1.67 1465720.0 -408250.37037037 -2.12793089744736 1452700.0 -362599.375 -1.74831296165034 -3.0028 -0.9235 2070055 Maybridge1_001136 COc1ccc(Cc2nc(cs2)C(C)(C)C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L15 compound treatment 1690400.0 -53900.0 -0.26 1630300.0 -151000.0 -0.67 1685460.0 -188510.37037037 -0.982576062910705 1598970.0 -216329.375 -1.04305599064592 -1.4791 -0.9226 2070056 Maybridge1_001137 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)NC(=N)c3ccc(Cl)cc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L16 compound treatment 1646400.0 -97900.0 -0.48 1599710.0 -181000.0 -0.8 1841760.0 -32210.3703703701 -0.167890704586873 1738890.0 -76409.375 -0.368416246454098 -0.9099 -0.892 2070057 Maybridge1_001138 Clc1cc(COc2ccc(cc2)S(=O)(=O)c3ccc(OCc4cc(Cl)cc5COCOc45)cc3)c6OCOCc6c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L17 compound treatment 1559740.0 -185000.0 -0.9 1750530.0 -30600.0 -0.14 1784170.0 -89800.3703703701 -0.468068118444004 1711790.0 -103509.375 -0.499081891591308 -1.0029 -0.8789 2070058 Maybridge1_001139 CC(=O)N1CCN(CC1)c2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L18 compound treatment 1875900.0 132000.0 0.64 1737170.0 -43900.0 -0.19 1794680.0 -79290.3703703701 -0.413286652570789 1702290.0 -113009.375 -0.544887191547157 -0.2545 -0.2653 2070059 Maybridge1_001140 Fc1ccc(NC(=O)CC#N)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L19 compound treatment 1560390.0 -184000.0 -0.9 1652810.0 -128000.0 -0.57 1718100.0 -155870.37037037 -0.812445991921007 1610800.0 -204499.375 -0.986016338174588 -1.6337 -0.9823 2070060 Maybridge1_001141 Nc1nc2c(F)cc(F)cc2s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L20 compound treatment 1309650.0 -435000.0 -2.13 1143710.0 -637000.0 -2.83 1426930.0 -447040.37037037 -2.33011672629817 1325330.0 -489969.375 -2.36244149379523 -4.8231 -0.9944 2070061 Maybridge1_001142 C/C(=N\NC(=S)N)/c1ccc(Cl)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L21 compound treatment 1565150.0 -179000.0 -0.88 1635060.0 -146000.0 -0.65 1651370.0 -222600.37037037 -1.16026399550993 1564870.0 -250429.375 -1.20747290943481 -1.946 -0.974 2070062 Maybridge1_001143 Cc1ccc2nc(N)sc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L22 compound treatment 1253030.0 -491000.0 -2.4 1266720.0 -514000.0 -2.28 1615150.0 -258820.37037037 -1.34905416619764 1580380.0 -234919.375 -1.13268973024374 -3.5834 -0.9548 1919994 Maybridge1_001144 CN(C)c1ccc(/C=N/NC(=S)N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L23 mock treatment 1962640.0 218000.0 1.07 1643520.0 -138000.0 -0.61 1985760.0 111789.62962963 0.582683138014738 1908980.0 93680.625 0.451691487176461 0.7463 0.5203 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 L24 mock treatment 1630240.0 -114000.0 -0.56 1883680.0 103000.0 0.45 1890880.0 16909.6296296299 0.0881383728338984 1876320.0 61020.625 0.294217687538775 0.1396 0.1783 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M01 compound treatment 1729620.0 -14700.0 -0.07 1568330.0 -213000.0 -0.94 1872290.0 -1680.3703703701 -0.00875862531862903 1653480.0 -161819.375 -0.780230001109786 -0.9022 -0.7356 1469999 Maybridge1_001145 NC(=O)c1cccnc1Oc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M02 compound treatment 1614460.0 -130000.0 -0.64 1830170.0 49100.0 0.22 1768240.0 -105730.37037037 -0.551100349781807 1475630.0 -339669.375 -1.63775343238849 -1.3033 -0.703 1365534 Maybridge1_001146 CC(C)(C)C(=O)Nc1cccc(F)c1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M03 compound treatment 1744490.0 190.0 0.0 1766150.0 -14900.0 -0.07 1821300.0 -52670.3703703701 -0.274534738056519 1619170.0 -196129.375 -0.945659458108225 -0.6428 -0.6513 1075845 Maybridge1_001147 OC(=O)c1ccccc1C(=O)Nc2cc(ccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M04 compound treatment 1117960.0 -626000.0 -3.06 1096510.0 -685000.0 -3.04 1199000.0 -674970.37037037 -3.51816044813279 1087360.0 -727939.375 -3.50984014963664 -6.5645 -0.9975 1223037 Maybridge1_001148 CC(C)(C)c1ccc(Oc2ccc(N)cn2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M05 compound treatment 1657130.0 -87200.0 -0.43 1779520.0 -1580.0 -0.01 1734990.0 -138980.37037037 -0.724409934965859 1663550.0 -151749.375 -0.731676383156586 -0.9448 -0.8477 1020373 Maybridge1_001149 Nc1ccc(Br)cn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M06 compound treatment 1608530.0 -136000.0 -0.66 1674330.0 -107000.0 -0.47 1699370.0 -174600.37037037 -0.91007271464273 1614150.0 -201149.375 -0.969863942927 -1.5089 -0.9671 2070063 Maybridge1_001150 CC(C)(C)SC(=S)SCC(=O)c1ccc(F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M07 compound treatment 1763840.0 19500.0 0.1 1763050.0 -18000.0 -0.08 1709710.0 -164260.37037037 -0.856177342889253 1576230.0 -239069.375 -1.15269941390866 -0.9966 -0.6915 1571162 Maybridge1_001151 CNc1ccccc1C(=O)NCc2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M08 compound treatment 1515260.0 -229000.0 -1.12 1426400.0 -355000.0 -1.57 1441040.0 -432930.37037037 -2.25657091435991 1476360.0 -338939.375 -1.63423365670767 -3.2923 -0.9711 2070064 Maybridge1_001152 CC1CCCN(C1)c2cc(N(C)C)c(cc2F)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M09 compound treatment 1720200.0 -24100.0 -0.12 1662950.0 -118000.0 -0.52 1802360.0 -71610.3703703701 -0.373256047632036 1643300.0 -171999.375 -0.829313996220369 -0.9222 -0.8732 1632631 Maybridge1_001153 O=C(NCCc1ccncc1)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M10 compound treatment 1733220.0 -11100.0 -0.05 1705240.0 -75900.0 -0.34 1843300.0 -30670.3703703701 -0.159863734325717 1624270.0 -191029.375 -0.921069244447717 -0.7358 -0.7395 1432647 Maybridge1_001154 COc1cc2CCN(Cc3cc(C)c(O)c(C)c3)C(C)c2cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M11 compound treatment 1866080.0 122000.0 0.6 1734720.0 -46400.0 -0.21 1770320.0 -103650.37037037 -0.540258727610895 1653240.0 -162059.375 -0.781387187634986 -0.4657 -0.4085 2070065 Maybridge1_001155 Clc1ccc(SCC(=O)NCc2cccs2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M12 compound treatment 1695100.0 -49200.0 -0.24 1799370.0 18300.0 0.08 1795450.0 -78520.3703703701 -0.409273167440211 1621350.0 -193949.375 -0.935148347170988 -0.7521 -0.7149 2070066 Maybridge1_001156 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)N3CCCCC3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M13 compound treatment 1793640.0 49300.0 0.24 1709350.0 -71700.0 -0.32 1814840.0 -59130.3703703701 -0.308206314606563 1658410.0 -156889.375 -0.756459461237961 -0.5707 -0.6277 2070067 Maybridge1_001157 COc1cc(cc(OC)c1OC)C2=NNC(=O)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M14 compound treatment 1676220.0 -68100.0 -0.33 1737570.0 -43500.0 -0.19 1503290.0 -370680.37037037 -1.93210409698526 1384160.0 -431139.375 -2.07878614680549 -2.2685 -0.7921 2070068 Maybridge1_001158 Fc1ccc(OC(=O)c2cccs2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M15 compound treatment 1299160.0 -445000.0 -2.18 1530740.0 -250000.0 -1.11 1613280.0 -260690.37037037 -1.35880120151476 1494080.0 -321219.375 -1.54879471826371 -3.0981 -0.969 1504770 Maybridge1_001159 Cc1nn(nc1C(=O)Nc2ccc3[nH]ncc3c2)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M16 compound treatment 1791110.0 46800.0 0.23 1743840.0 -37300.0 -0.17 1707200.0 -166770.37037037 -0.869260261951268 1684960.0 -130339.375 -0.628445701887668 -0.7169 -0.6464 2070069 Maybridge1_001160 Fc1ccc(NC(=O)CSCc2c(Cl)cccc2Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M17 compound treatment 1917810.0 174000.0 0.85 1746420.0 -34700.0 -0.15 1895540.0 21569.6296296299 0.112427776351423 1787890.0 -27409.375 -0.132157330892352 0.3378 0.3838 1236643 Maybridge1_001161 Fc1cccc(F)c1C(=O)NC(=O)N2CCSC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M18 compound treatment 1465440.0 -279000.0 -1.36 1613710.0 -167000.0 -0.74 1522880.0 -351090.37037037 -1.82999478048133 1516240.0 -299059.375 -1.44194782910354 -2.6894 -0.9604 1108196 Maybridge1_001162 [O-][N+](=O)c1ccc(cc1)c2noc(n2)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M19 compound treatment 1678720.0 -65600.0 -0.32 1767240.0 -13900.0 -0.06 1856250.0 -17720.3703703701 -0.0923642116750863 1736000.0 -79299.375 -0.382350700861719 -0.4285 -0.838 1093772 Maybridge1_001163 O=C(Nc1nncs1)c2ccncc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M20 compound treatment 1648030.0 -96300.0 -0.47 1682180.0 -98900.0 -0.44 1854530.0 -19440.3703703701 -0.101329399239494 1745140.0 -70159.375 -0.338281180693671 -0.6747 -0.9189 1737692 Maybridge1_001164 CC(=O)Nc1cccc(F)c1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M21 compound treatment 1748420.0 4120.0 0.02 1517860.0 -263000.0 -1.17 1751240.0 -122730.37037037 -0.639709761755608 1629070.0 -186229.375 -0.897925513943709 -1.3424 -0.836 2070070 Maybridge1_001165 Cc1cc(Oc2ccc(cn2)[N+](=O)[O-])cc(C)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M22 compound treatment 1787960.0 43700.0 0.21 1807710.0 26600.0 0.12 1789960.0 -84010.3703703701 -0.437888795189397 1784800.0 -30499.375 -0.147056107404307 -0.1266 -0.2424 2070071 Maybridge1_001166 CC(C)(C)c1cc([N+](=O)[O-])c(OC(=O)c2ccc(Cl)cc2Cl)c(c1)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M23 mock treatment 2005530.0 261000.0 1.28 1725120.0 -56000.0 -0.25 1957240.0 83269.6296296299 0.434027818632807 1879780.0 64480.625 0.310900459943747 0.8875 0.6306 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 M24 mock treatment 1652380.0 -91900.0 -0.45 1913070.0 132000.0 0.59 1924340.0 50369.6296296299 0.262542544871745 1785120.0 -30179.375 -0.145513192037373 0.1262 0.1584 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N01 compound treatment 1602960.0 -141000.0 -0.69 1832210.0 51100.0 0.23 1820520.0 -53450.3703703701 -0.278600346370611 1648060.0 -167239.375 -0.806363130137228 -0.775 -0.6911 1602236 Maybridge1_001167 S=C(NCc1ccccn1)Nc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N02 compound treatment 1672610.0 -71700.0 -0.35 1838720.0 57600.0 0.26 1916130.0 42159.6296296299 0.21974941120675 1634210.0 -181089.375 -0.873142435862334 -0.3743 -0.3745 1628081 Maybridge1_001168 Cc1onc(c1C(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N03 compound treatment 1616260.0 -128000.0 -0.63 1638580.0 -143000.0 -0.63 1581390.0 -292580.37037037 -1.52502203374091 1578430.0 -236869.375 -1.14209187076099 -1.9628 -0.9334 2070072 Maybridge1_001169 [O-][N+](=O)c1ccc(Sc2ncc3ccccn23)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N04 compound treatment 1746330.0 2030.0 0.01 1773320.0 -7780.0 -0.03 1778190.0 -95780.3703703701 -0.499237782185376 1688420.0 -126879.375 -0.611762929482696 -0.5678 -0.7183 1468368 Maybridge1_001170 Clc1ccc(Oc2ccccc2NS(=O)(=O)c3ccc(Cl)c(Cl)c3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N05 compound treatment 1526790.0 -218000.0 -1.06 1782800.0 1700.0 0.01 1657500.0 -216470.37037037 -1.12831248401585 1564490.0 -250809.375 -1.20930512143305 -1.6972 -0.8629 2070073 Maybridge1_001171 Cc1cc(Oc2ncccc2[N+](=O)[O-])c3cc(Cl)ccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N06 compound treatment 487210.0 -1260000.0 -6.15 635050.0 -1150000.0 -5.08 670090.0 -1203880.37037037 -6.2750077473718 648440.0 -1166859.375 -5.62614143980728 -11.5675 -0.9967 1602444 Maybridge1_001172 Cc1c(Cl)cccc1Nc2nc(cs2)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N07 compound treatment 1707080.0 -37200.0 -0.18 1704960.0 -76100.0 -0.34 1707400.0 -166570.37037037 -0.868217798280988 1597250.0 -218049.375 -1.05134916074319 -1.2197 -0.8611 2070074 Maybridge1_001173 Clc1ccc(cc1)C2=NNC(=O)CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N08 compound treatment 1746190.0 1890.0 0.01 1788250.0 7150.0 0.03 1878310.0 4339.6296296299 0.0226195311567994 1761690.0 -53609.375 -0.258483526560061 -0.0974 -0.3725 2070075 Maybridge1_001174 C/C(=N\Nc1c(Cl)cc(Cl)cc1Cl)/c2cc(F)ccc2OC(=O)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N09 compound treatment 1670020.0 -74300.0 -0.36 1748520.0 -32600.0 -0.14 1659550.0 -214420.37037037 -1.11762723139548 1574820.0 -240479.375 -1.15949788474421 -1.3925 -0.8403 2070076 Maybridge1_001175 C/C(=N\Nc1ccccc1)/C=N/O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N10 compound treatment 1455370.0 -289000.0 -1.41 1558090.0 -223000.0 -0.99 1590440.0 -283530.37037037 -1.47785055266074 1436170.0 -379129.375 -1.82801418357352 -2.8543 -0.9789 1595657 Maybridge1_001176 Cc1ccc(cc1C)n2c(csc2=Nc3ccccn3)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N11 compound treatment 1821360.0 77100.0 0.38 1804800.0 23700.0 0.11 1874430.0 459.629629629897 0.00239573595336713 1722430.0 -92869.375 -0.447779955640758 0.0184 0.031 2070077 Maybridge1_001177 Cc1cc(ccc1Cl)C2=Nc3ccccc3SC(C2)c4c(Cl)cccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N12 compound treatment 942150.0 -802000.0 -3.93 1050800.0 -730000.0 -3.24 1095920.0 -778050.37037037 -4.05544622379511 917000.0 -898299.375 -4.33124971810805 -7.7753 -0.9947 1257335 Maybridge1_001178 Fc1ccc(Oc2ccnc3cc(Cl)ccc23)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N13 compound treatment 1183890.0 -560000.0 -2.74 1471380.0 -310000.0 -1.37 1763080.0 -110890.37037037 -0.577995912475031 1441150.0 -374149.375 -1.80400256317561 -3.2489 -0.9012 2070078 Maybridge1_001179 Fc1cc(Br)c(c(Br)c1Cl)n2cccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N14 compound treatment 1567560.0 -177000.0 -0.86 1495840.0 -285000.0 -1.27 1582460.0 -291510.37037037 -1.51944485310491 1376740.0 -438559.375 -2.11456249687627 -2.882 -0.9539 2070079 Maybridge1_001180 Cc1ccc(Cc2nc(cs2)C(C)(C)C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N15 compound treatment 1739240.0 -5060.0 -0.02 1750560.0 -30500.0 -0.14 1828590.0 -45380.3703703701 -0.236536937274812 1659260.0 -156039.375 -0.752361092294543 -0.5745 -0.7176 2070080 Maybridge1_001181 CS(=O)(=O)NNc1c(Cl)cc(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N16 compound treatment 1265050.0 -479000.0 -2.35 1536050.0 -245000.0 -1.09 1575040.0 -298930.37037037 -1.5581202552723 1479200.0 -336099.375 -1.62054028282613 -3.3053 -0.9649 1633692 Maybridge1_001182 Cc1onc(c1C(=O)Nc2nnc(s2)C3CC3)c4c(Cl)cccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N17 compound treatment 1826660.0 82400.0 0.4 1726920.0 -54200.0 -0.24 1805920.0 -68050.3703703701 -0.354700194301052 1695420.0 -119879.375 -0.578011655831018 -0.385 -0.4668 1014750 Maybridge1_001183 COc1ccc(NC(=O)CC(=O)C)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N18 compound treatment 1399890.0 -344000.0 -1.69 1319800.0 -461000.0 -2.05 1711800.0 -162170.37037037 -0.845283597534827 1573080.0 -242219.375 -1.16788748705192 -2.8721 -0.9519 2070081 Maybridge1_001184 Fc1ccc(OCOc2ccc(F)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N19 compound treatment 1895250.0 151000.0 0.74 1827370.0 46300.0 0.21 1867900.0 -6070.3703703701 -0.0316407028812754 1743060.0 -72239.375 -0.348310130578741 0.282 0.3346 2070082 Maybridge1_001185 Oc1ccnc(SCc2c(Cl)cccc2Cl)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N20 compound treatment 1167960.0 -576000.0 -2.82 1237620.0 -543000.0 -2.41 1221700.0 -652270.37037037 -3.399840821556 1224020.0 -591279.375 -2.85091885574545 -5.7406 -0.9926 2070083 Maybridge1_001186 CS/C(=N/N=C(\C)/c1ccc(Cl)c(Cl)c1)/N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N21 compound treatment 1598990.0 -145000.0 -0.71 1568960.0 -212000.0 -0.94 1681770.0 -192200.37037037 -1.00180951762737 1629820.0 -185479.375 -0.894309306052458 -1.774 -0.9926 2070084 Maybridge1_001187 Nc1nc2ccc(Cl)cc2s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N22 compound treatment 1225610.0 -519000.0 -2.54 1255530.0 -526000.0 -2.33 1377280.0 -496690.37037037 -2.58890833244518 1439380.0 -375919.375 -1.81253681379897 -4.6352 -0.9913 2070085 Maybridge1_001188 NC(=S)N/N=C/c1ccc2OCOc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N23 mock treatment 2013490.0 269000.0 1.32 1889890.0 109000.0 0.48 1997870.0 123899.62962963 0.645804313250193 1874920.0 59620.625 0.287467432808439 1.3665 0.8699 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 N24 mock treatment 1692440.0 -51900.0 -0.25 1814990.0 33900.0 0.15 1880860.0 6889.6296296299 0.0359109429528696 1796090.0 -19209.375 -0.0926201246146717 -0.0801 -0.2573 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O01 compound treatment 1423330.0 -321000.0 -1.57 1794110.0 13000.0 0.06 1835440.0 -38530.3703703701 -0.200832556567722 1721990.0 -93309.375 -0.449901464270292 -1.0818 -0.6568 1177922 Maybridge1_001189 O=c1c2ccccc2oc3ncccc13 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O02 compound treatment 1683550.0 -60700.0 -0.3 1897310.0 116000.0 0.52 1839420.0 -34550.3703703701 -0.18008752952915 1771160.0 -44139.375 -0.212822874919862 -0.0874 -0.133 1120165 Maybridge1_001190 Fc1cccc(NC(=O)C(C2CCCC2)c3ccccc3)c1C(=O)NCc4cccs4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O03 compound treatment 1711220.0 -33100.0 -0.16 1711150.0 -69900.0 -0.31 1843050.0 -30920.3703703701 -0.161166813913567 1679910.0 -135389.375 -0.652794835022093 -0.643 -0.8483 2070086 Maybridge1_001191 COC(=O)c1c(OC)ccc([N+](=O)[O-])c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O04 compound treatment 1770180.0 25900.0 0.13 1613780.0 -167000.0 -0.74 1788000.0 -85970.3703703701 -0.448104939158141 1638740.0 -176559.375 -0.851300540199177 -0.9574 -0.7838 2070087 Maybridge1_001192 Cc1cc(Oc2ccc(cn2)[N+](=O)[O-])ccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O05 compound treatment 1819930.0 75600.0 0.37 1754440.0 -26700.0 -0.12 1888390.0 14419.6296296299 0.0751597001389122 1751950.0 -63349.375 -0.30544601304111 0.0108 0.0216 1033922 Maybridge1_001193 Nc1ncc(Br)cc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O06 compound treatment 1613480.0 -131000.0 -0.64 1693370.0 -87700.0 -0.39 1706440.0 -167530.37037037 -0.873221623898332 1517760.0 -297539.375 -1.43461898111061 -1.6685 -0.9073 1034245 Maybridge1_001194 [O-][N+](=O)c1ccc(Oc2c(Cl)cccc2Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O07 compound treatment 1556610.0 -188000.0 -0.92 1740800.0 -40300.0 -0.18 1678630.0 -195340.37037037 -1.01817619725077 1586310.0 -228989.375 -1.10409757985024 -1.6097 -0.9097 1249559 Maybridge1_001195 OC(=O)c1ccccc1NCC(=O)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O08 compound treatment 1725070.0 -19200.0 -0.09 1718100.0 -63000.0 -0.28 1879900.0 5929.6296296299 0.0309071173355256 1777350.0 -37949.375 -0.182977105790735 -0.2628 -0.7544 1221542 Maybridge1_001196 Clc1ccc(NC(=O)NC(=O)c2ccccc2N3CCCCC3)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O09 compound treatment 1710120.0 -34200.0 -0.17 1861830.0 80700.0 0.36 1977630.0 103659.62962963 0.540306989817855 1683570.0 -131729.375 -0.635147740512787 0.048 0.052 1284064 Maybridge1_001197 CC(C)NC(=S)NCCc1ccncc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O10 compound treatment 1755390.0 11100.0 0.05 1815220.0 34100.0 0.15 1806880.0 -67090.3703703701 -0.349696368683708 1797500.0 -17799.375 -0.0858216537791194 -0.115 -0.2915 2070088 Maybridge1_001198 [O-][N+](=O)c1cccnc1Sc2ccccn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O11 compound treatment 1862140.0 118000.0 0.58 1855930.0 74800.0 0.33 1879070.0 5099.6296296299 0.0265808931038635 1734560.0 -80739.375 -0.389293820012921 0.2729 0.3538 2070089 Maybridge1_001199 SC1=NCN(CCc2ccncc2)CN1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O12 compound treatment 1811000.0 66700.0 0.33 1771440.0 -9660.0 -0.04 1831100.0 -42870.3703703701 -0.223454018212798 1681360.0 -133939.375 -0.645803499765674 -0.2928 -0.3861 2070090 Maybridge1_001200 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)N3CCOCC3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O13 compound treatment 1805470.0 61200.0 0.3 1634890.0 -146000.0 -0.65 1839270.0 -34700.3703703701 -0.18086937728186 1766910.0 -48389.375 -0.233314719636952 -0.3816 -0.4938 2070091 Maybridge1_001201 CC(=O)C(=NNc1ccc(F)cc1F)C(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O14 compound treatment 1751460.0 7160.0 0.04 1813550.0 32500.0 0.14 1741090.0 -132880.37037037 -0.692614793022319 1669990.0 -145309.375 -0.700625211397043 -0.6071 -0.6094 2070092 Maybridge1_001202 Fc1ccc(OC(=O)c2ccccc2Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O15 compound treatment 1663940.0 -80400.0 -0.39 1736280.0 -44800.0 -0.2 1715550.0 -158420.37037037 -0.825737403717077 1670920.0 -144379.375 -0.696141113611891 -1.0569 -0.9061 2070093 Maybridge1_001203 Cc1nn(nc1C(=O)NN)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O16 compound treatment 1568000.0 -176000.0 -0.86 1786270.0 5170.0 0.02 1600800.0 -273170.37037037 -1.42385093454024 1606160.0 -209139.375 -1.00838861099513 -1.636 -0.8405 2070094 Maybridge1_001204 Fc1ccc(NC(=O)CSCc2c(F)cccc2Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O17 compound treatment 1469830.0 -274000.0 -1.34 1614470.0 -167000.0 -0.74 1763320.0 -110650.37037037 -0.576744956070695 1595400.0 -219899.375 -1.06026914020828 -1.8595 -0.9531 1542709 Maybridge1_001205 Cc1ccc(SCc2ccc(cc2)C(=O)Nc3ccc(C)cc3O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O18 compound treatment 1855410.0 111000.0 0.54 1737350.0 -43700.0 -0.19 1848240.0 -25730.3703703701 -0.134114881669801 1772960.0 -42339.375 -0.204143975980859 0.0057 0.0091 2070095 Maybridge1_001206 CC1CN(CC(C)O1)c2ccc(cc2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O19 compound treatment 1880520.0 136000.0 0.67 1587070.0 -194000.0 -0.86 1758520.0 -115450.37037037 -0.601764084157416 1512400.0 -302899.375 -1.46046281350675 -1.1281 -0.5881 1582082 Maybridge1_001207 CCc1nnc(NC(=O)c2ccncc2)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O20 compound treatment 1821030.0 76700.0 0.38 1849010.0 67900.0 0.3 1746320.0 -127650.37037037 -0.665354368044497 1715850.0 -99449.375 -0.479506152873335 -0.2341 -0.2462 1207012 Maybridge1_001208 S=C1NCN(CN1)C2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O21 compound treatment 1810950.0 66700.0 0.33 1683060.0 -98000.0 -0.43 1789760.0 -84210.3703703701 -0.438931258859677 1651200.0 -164099.375 -0.79122327309919 -0.6694 -0.6342 2070096 Maybridge1_001209 Fc1cc2nn[nH]c2cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O22 compound treatment 1522000.0 -222000.0 -1.09 1656180.0 -125000.0 -0.55 1833730.0 -40240.3703703701 -0.209745620948616 1800890.0 -14409.375 -0.069476394110664 -0.9605 -0.7742 2070097 Maybridge1_001210 CCOC(=O)c1cnc(Sc2ccc(cc2[N+](=O)[O-])C(F)(F)F)nc1N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O23 mock treatment 2056230.0 312000.0 1.53 1963530.0 182000.0 0.81 1942080.0 68109.6296296299 0.355009072425582 1679550.0 -135749.375 -0.654530614809894 1.018 0.5411 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 O24 mock treatment 1645450.0 -98800.0 -0.48 1772010.0 -9090.0 -0.04 1877830.0 3859.6296296299 0.0201176183481274 1849350.0 34050.625 0.164178851769381 -0.1699 -0.3312 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P01 compound treatment 1723400.0 -20900.0 -0.1 1782740.0 1640.0 0.01 1840110.0 -33860.3703703701 -0.176491029866684 1551960.0 -263339.375 -1.26971990126955 -0.7706 -0.5992 1307492 Maybridge1_001211 Clc1ccc(cc1)S(=O)(=O)NC2CCS(=O)(=O)C2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P02 compound treatment 1593640.0 -151000.0 -0.74 1809780.0 28700.0 0.13 1841360.0 -32610.3703703701 -0.169975631927433 1659630.0 -155669.375 -0.750577096401526 -0.7653 -0.713 1494020 Maybridge1_001212 Cc1onc(c1C(=O)Nc2ccccc2Oc3ccc(Cl)cc3Cl)c4c(Cl)cccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P03 compound treatment 1767360.0 23100.0 0.11 1818420.0 37300.0 0.17 1874730.0 759.629629629897 0.00395943145878716 1783650.0 -31649.375 -0.152600959504225 0.0649 0.2575 2070098 Maybridge1_001213 Cc1cc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)c3c(Cl)ccc(C)c3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P04 compound treatment 1694340.0 -50000.0 -0.24 1919060.0 138000.0 0.61 1851050.0 -22920.3703703701 -0.119468267102367 1772650.0 -42649.375 -0.205638675242576 0.0211 0.0302 2070099 Maybridge1_001214 Clc1ccc(Oc2ccccc2NC(=O)C(Cl)(Cl)Cl)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P05 compound treatment 917150.0 -827000.0 -4.05 1040480.0 -741000.0 -3.28 1024920.0 -849050.37037037 -4.42552082674451 932550.0 -882749.375 -4.2562736744961 -8.0069 -0.9941 2070100 Maybridge1_001215 Cc1cc(Oc2ncccc2[N+](=O)[O-])c3ccccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P06 compound treatment 640970.0 -1100000.0 -5.4 989120.0 -792000.0 -3.51 1060760.0 -813210.37037037 -4.23871133703033 961810.0 -853489.375 -4.11519335063209 -8.6326 -0.9877 1419346 Maybridge1_001216 Cc1ccc(Nc2nc(cs2)C(C)(C)C)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P07 compound treatment 1197770.0 -547000.0 -2.67 1256890.0 -524000.0 -2.32 1296990.0 -576980.37037037 -3.00740537287909 1194300.0 -620999.375 -2.99421712044943 -5.5004 -0.9949 1133002 Maybridge1_001217 COc1cc(cc(OC)c1OC)C(=O)c2ccccc2C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P08 compound treatment 1844350.0 100000.0 0.49 1821150.0 40100.0 0.18 1827170.0 -46800.3703703701 -0.2439384293338 1753550.0 -61749.375 -0.297731436206441 0.0628 0.0969 2070101 Maybridge1_001218 CCOc1c(Br)cc(Br)cc1/C=C\2/SC(=S)NC2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P09 compound treatment 1787550.0 43300.0 0.21 1809300.0 28200.0 0.13 1829860.0 -44110.3703703701 -0.229917292968534 1684820.0 -130479.375 -0.629120727360702 -0.2612 -0.366 1920882 Maybridge1_001219 Clc1cccc(Cl)c1/C=N/NC(=O)c2cccnc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P10 compound treatment 1374050.0 -370000.0 -1.81 1349570.0 -432000.0 -1.91 1406460.0 -467510.37037037 -2.43681288295133 1263840.0 -551459.375 -2.65892232477262 -4.4106 -0.9874 2070102 Maybridge1_001220 OC1(CSc2nc3cc(ccc3n21)C(F)(F)F)c4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P11 compound treatment 1634440.0 -110000.0 -0.54 1621280.0 -160000.0 -0.71 1665500.0 -208470.37037037 -1.08661393720465 1512370.0 -302929.375 -1.4606074618224 -1.8968 -0.9361 2070103 Maybridge1_001221 CCCc1cc(Br)c(c(Br)c1)n2cccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P12 compound treatment 1431150.0 -313000.0 -1.53 1260610.0 -520000.0 -2.31 1300120.0 -573850.37037037 -2.99109081643921 1181080.0 -634219.375 -3.05795881154588 -4.9448 -0.9702 1410530 Maybridge1_001222 Clc1ccc(Oc2ccnc3cc(Cl)ccc23)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P13 compound treatment 1683040.0 -61300.0 -0.3 1784030.0 2930.0 0.01 1854920.0 -19050.3703703701 -0.0992965950824484 1776030.0 -39269.375 -0.189341631679338 -0.2877 -0.7809 2070104 Maybridge1_001223 [O-][N+](=O)c1ccc(Oc2c(Cl)cc(cc2Cl)S(=O)(=O)NC(=N)c3ccc(Cl)cc3)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P14 compound treatment 1388730.0 -356000.0 -1.74 1546940.0 -234000.0 -1.04 1352640.0 -521330.37037037 -2.71733985662368 1594270.0 -221029.375 -1.06571756009777 -3.2807 -0.9233 2070105 Maybridge1_001224 CC(C)(C)c1csc(Cc2ccc(cc2)[N+](=O)[O-])n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P15 compound treatment 1140330.0 -604000.0 -2.96 1309920.0 -471000.0 -2.09 1223450.0 -650520.37037037 -3.39071926444105 1452000.0 -363299.375 -1.75168808901551 -5.0937 -0.9684 2070106 Maybridge1_001225 Clc1cc(Cl)c(NNS(=O)(=O)c2ccc(Cl)c(Cl)c2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P16 compound treatment 1784830.0 40500.0 0.2 1786880.0 5780.0 0.03 1786990.0 -86980.3703703701 -0.453369380693056 1705140.0 -110159.375 -0.531145601560402 -0.3803 -0.5235 2070107 Maybridge1_001226 COC(=O)/C=C/1\SC(=NC1=O)Cc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P17 compound treatment 1062960.0 -681000.0 -3.33 1036160.0 -745000.0 -3.3 1086640.0 -787330.37037037 -4.1038165380961 1092830.0 -722469.375 -3.48346594008311 -7.1125 -0.9959 1036063 Maybridge1_001227 Clc1ccc(NC(=S)Nc2ccc(Cl)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P18 compound treatment 1341710.0 -403000.0 -1.97 1276600.0 -504000.0 -2.24 1329120.0 -544850.37037037 -2.83993358424861 1285440.0 -529859.375 -2.55477553750458 -4.801 -0.9908 2070108 Maybridge1_001228 Fc1cccc(NC(=S)NN=C2CCCCCC2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P19 compound treatment 1933050.0 189000.0 0.92 1794890.0 13800.0 0.06 1782720.0 -91250.3703703701 -0.475625980053534 1756960.0 -58339.375 -0.281289744327552 0.1139 0.1057 2070109 Maybridge1_001229 CC(=O)Nc1cc2cc(NC(=O)c3ccc(cc3)[N+](=O)[O-])ccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P20 compound treatment 1384990.0 -359000.0 -1.76 1513680.0 -267000.0 -1.19 1519750.0 -354220.37037037 -1.84630933692121 1544830.0 -270469.375 -1.30409798428905 -3.0473 -0.9831 2070110 Maybridge1_001230 C/C(=N\Nc1nc(cs1)C(C)(C)C)/c2ccc(Cl)c(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P21 compound treatment 1605850.0 -138000.0 -0.68 1538160.0 -243000.0 -1.08 1564020.0 -309950.37037037 -1.61556000350473 1706880.0 -108419.375 -0.5227559992527 -1.9466 -0.9173 1723356 Maybridge1_001231 Clc1ccc2sc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)nc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P22 compound treatment 627560.0 -1120000.0 -5.46 757600.0 -1020000.0 -4.54 881690.0 -992280.37037037 -5.17208118421554 834790.0 -980509.375 -4.7276343190944 -9.9517 -0.9973 2070111 Maybridge1_001232 CC(C)(C)c1csc(N/N=C/c2ccc(Cl)cc2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P23 mock treatment 2007580.0 263000.0 1.29 1951630.0 171000.0 0.76 1952500.0 78529.6296296299 0.409321429647171 1878730.0 63430.625 0.305837768895995 1.3799 0.874 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.544 P24 mock treatment 1955720.0 211000.0 1.03 1975810.0 195000.0 0.86 1914400.0 40429.6296296299 0.210732100458828 1872580.0 57280.625 0.276184864187735 1.1925 0.8569 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A01 compound treatment 1485160.0 -335000.0 -1.64 1513880.0 -118000.0 -0.52 1526530.0 -286345.3125 -1.49252292718114 1396650.0 -231392.5 -1.11568451263513 -2.3851 -0.9402 2070112 Maybridge1_001233 CS/C(=N\N=C(/C)\c1ccc(Br)cc1)/N=C/N(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A02 compound treatment 1518370.0 -302000.0 -1.48 1559280.0 -72300.0 -0.32 1582270.0 -230605.3125 -1.2019883022741 1445200.0 -182842.5 -0.881595321808134 -1.9409 -0.9141 2070113 Maybridge1_001234 CC(C)c1ccc(cc1)S(=O)(=O)NC(=N)CSc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A03 compound treatment 1603550.0 -217000.0 -1.06 1534330.0 -97200.0 -0.43 1595780.0 -217095.3125 -1.13156988134668 1470240.0 -157802.5 -0.76086219434556 -1.6922 -0.9504 2070114 Maybridge1_001235 Cc1onc(c1C(=O)Oc2ccc(cc2)c3ccc(OC(=O)c4c(C)onc4c5c(Cl)cccc5Cl)cc3)c6c(Cl)cccc6Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A04 compound treatment 1586480.0 -234000.0 -1.14 1615230.0 -16300.0 -0.07 1670250.0 -142625.3125 -0.743408533717921 1454630.0 -173412.5 -0.836127534588802 -1.3981 -0.8727 2070115 Maybridge1_001236 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1OC(=O)c2c(F)cccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A05 compound treatment 1549500.0 -271000.0 -1.33 1486240.0 -145000.0 -0.64 1676640.0 -136235.3125 -0.710101819452474 1493760.0 -134282.5 -0.647457914875922 -1.6636 -0.9456 2070116 Maybridge1_001237 Fc1ccc(NC(=O)CC#N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A06 compound treatment 1409050.0 -411000.0 -2.01 1459370.0 -172000.0 -0.76 1675050.0 -137825.3125 -0.7183894056312 1512750.0 -115292.5 -0.555895531069441 -2.0252 -0.8668 2070117 Maybridge1_001238 OCCCc1nc2cc(ccc2[nH]1)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A07 compound treatment 1577250.0 -243000.0 -1.19 1549920.0 -81600.0 -0.36 1594500.0 -218375.3125 -1.13824164883648 1553170.0 -74872.5 -0.361006033783609 -1.5254 -0.8848 1705513 Maybridge1_001239 COC(=O)c1sc2ccccc2c1OC(=O)c3cccnc3Oc4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A08 compound treatment 1578560.0 -242000.0 -1.18 1474720.0 -157000.0 -0.7 1620480.0 -192395.3125 -1.0028256180671 1372110.0 -255932.5 -1.23400683483687 -2.0577 -0.9797 2070118 Maybridge1_001240 CCOC(=O)c1cc(CC)sc1NC(=O)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A09 compound treatment 1347850.0 -472000.0 -2.31 1309630.0 -322000.0 -1.43 1401120.0 -411755.3125 -2.14619977163022 1348820.0 -279222.5 -1.34630214388652 -3.6161 -0.9733 2070119 Maybridge1_001241 CSC1=NC=C(C#N)C2=NC(NN21)c3ccc4OCOc4c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A10 compound treatment 1644480.0 -176000.0 -0.86 1482400.0 -149000.0 -0.66 1616830.0 -196045.3125 -1.02185058004971 1561060.0 -66982.5 -0.322963526767646 -1.4334 -0.9398 1020861 Maybridge1_001242 [O-][N+](=O)c1ccc(cc1)N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A11 compound treatment 1534500.0 -286000.0 -1.4 1498020.0 -134000.0 -0.59 1678580.0 -134295.3125 -0.699989921850758 1519800.0 -108242.5 -0.521903176891679 -1.6064 -0.9169 1214080 Maybridge1_001243 Clc1ccc(cc1Cl)S(=O)(=O)Nc2ccc3oc4ncccc4c(=O)c3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A12 compound treatment 1421380.0 -399000.0 -1.95 1334010.0 -298000.0 -1.32 1323700.0 -489175.3125 -2.54973745839562 1323630.0 -304412.5 -1.46775851292735 -3.6446 -0.9669 2070120 Maybridge1_001244 Cc1cc(OC(=O)c2c(C)onc2c3ccccc3)n(n1)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A13 compound treatment 1571150.0 -249000.0 -1.22 1398420.0 -233000.0 -1.03 1606040.0 -206835.3125 -1.07809149506132 1474450.0 -153592.5 -0.740563214049336 -2.0359 -0.9857 2070121 Maybridge1_001245 [O-][N+](=O)c1cc(ccc1OC(=O)c2c(F)cccc2F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A14 compound treatment 1653060.0 -167000.0 -0.82 1379950.0 -252000.0 -1.12 1620720.0 -192155.3125 -1.00157466166277 1573920.0 -54122.5 -0.260957615458992 -1.5984 -0.925 2070122 Maybridge1_001246 Nc1cc(ccc1N2CCCC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A15 compound treatment 895600.0 -925000.0 -4.53 835840.0 -796000.0 -3.53 1122290.0 -690585.3125 -3.59955049755111 926030.0 -702012.5 -3.38483085634266 -7.5191 -0.993 2070123 Maybridge1_001247 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1Oc2ccc(Cl)c(Cl)c2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A16 compound treatment 1464320.0 -356000.0 -1.74 1360870.0 -271000.0 -1.2 1512160.0 -300715.3125 -1.56742394189076 1437620.0 -190422.5 -0.918143129562379 -2.714 -0.9733 2070124 Maybridge1_001248 Cc1cc(OC(=O)c2cccc(F)c2)n(n1)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A17 compound treatment 1659570.0 -161000.0 -0.79 1480240.0 -151000.0 -0.67 1615950.0 -196925.3125 -1.02643742019894 1533210.0 -94832.5 -0.457245379796108 -1.4707 -0.9631 2070125 Maybridge1_001249 Fc1ccc(cc1)c2cnc3c(Cl)cc(cc3n2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A18 compound treatment 1688760.0 -132000.0 -0.64 1523200.0 -108000.0 -0.48 1717600.0 -95275.3125 -0.496605259779127 1559470.0 -68572.5 -0.330629887497099 -0.9758 -0.9751 2070126 Maybridge1_001250 COc1ccc([N+](=O)[O-])c(OC)c1C(=O)NCC2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A19 compound treatment 1541200.0 -279000.0 -1.37 1491680.0 -140000.0 -0.62 1722450.0 -90425.3125 -0.471325515774837 1502080.0 -125962.5 -0.607342115335642 -1.5324 -0.9091 2070127 Maybridge1_001251 CC(C)(COC(=O)c1ccc(o1)[N+](=O)[O-])Nc2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A20 compound treatment 1714990.0 -105000.0 -0.52 1256480.0 -375000.0 -1.66 1693160.0 -119715.3125 -0.623994320287345 1613280.0 -14762.5 -0.0711790253261281 -1.437 -0.7763 2070128 Maybridge1_001252 Oc1cc(ccc1[N+](=O)[O-])N2CCSCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A21 compound treatment 1438900.0 -381000.0 -1.87 1334560.0 -297000.0 -1.32 1607650.0 -205225.3125 -1.06969966251557 1496800.0 -131242.5 -0.63280021889005 -2.443 -0.9394 2070129 Maybridge1_001253 O=C/1NC(=S)S\C1=C/c2ccc(C#N)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A22 compound treatment 1617600.0 -203000.0 -0.99 1431850.0 -200000.0 -0.89 1698530.0 -114345.3125 -0.596004170740327 1459580.0 -168462.5 -0.812260562506544 -1.643 -0.9848 2070130 Maybridge1_001254 CCC(CC)(NC(=O)NC(=O)c1ccc(F)c(Cl)c1)C#C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A23 mock treatment 1742200.0 -78100.0 -0.38 1583040.0 -48500.0 -0.22 1746660.0 -66215.3125 -0.345135288487441 1589760.0 -38282.5 -0.184583304795766 -0.5636 -0.9586 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 A24 mock treatment 1698360.0 -122000.0 -0.6 1567800.0 -63800.0 -0.28 1660380.0 -152495.3125 -0.794854115846239 1618400.0 -9642.5 -0.0464923794551865 -0.8605 -0.8318 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B01 compound treatment 1544040.0 -276000.0 -1.35 1613230.0 -18300.0 -0.08 1621710.0 -191165.3125 -0.99641446649488 1035970.0 -592072.5 -2.85474299559045 -2.6422 -0.7975 1223843 Maybridge1_001255 COC(=O)c1sccc1OC(=O)c2c(F)cccc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B02 compound treatment 1351040.0 -469000.0 -2.3 1580440.0 -51100.0 -0.23 1671430.0 -141445.3125 -0.737257998063269 1299390.0 -328652.5 -1.58463435197259 -2.4225 -0.8369 1150918 Maybridge1_001256 CCCc1cc(=O)oc2n(nc(C)c12)c3cccc(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B03 compound treatment 1355930.0 -464000.0 -2.27 1471570.0 -160000.0 -0.71 1531720.0 -281155.3125 -1.46547099493737 1382830.0 -245212.5 -1.18231917004458 -2.8149 -0.9274 2070131 Maybridge1_001257 [O-][N+](=O)c1cc(ccc1NCCCn2ccnc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B04 compound treatment 1337480.0 -483000.0 -2.36 1579720.0 -51800.0 -0.23 1645120.0 -167755.3125 -0.874394093888605 1356930.0 -271112.5 -1.30719888255579 -2.3871 -0.8383 2070132 Maybridge1_001258 Oc1cc(ccc1[N+](=O)[O-])S(=O)(=O)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B05 compound treatment 1390280.0 -430000.0 -2.1 1590570.0 -41000.0 -0.18 1579640.0 -233235.3125 -1.21569669953828 1417340.0 -210702.5 -1.01592539094181 -2.2589 -0.8555 2070133 Maybridge1_001259 CN(C)/C=N/c1nnc(Sc2nc3cc(Cl)ccc3s2)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B06 compound treatment 1374010.0 -446000.0 -2.18 1576320.0 -55200.0 -0.24 1620640.0 -192235.3125 -1.00199164713088 1528640.0 -99402.5 -0.479280139880132 -1.9551 -0.794 2070134 Maybridge1_001260 Cc1ccc(cc1)S(=O)(=O)Oc2ccc(OCc3ccccc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B07 compound treatment 1550640.0 -270000.0 -1.32 1491610.0 -140000.0 -0.62 1631110.0 -181765.3125 -0.94741867399172 1487200.0 -140842.5 -0.679087679898066 -1.7834 -0.9553 1257406 Maybridge1_001261 Clc1ccc2sc3nc4ccccc4c(=O)n3c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B08 compound treatment 1547470.0 -273000.0 -1.34 1523300.0 -108000.0 -0.48 1723720.0 -89155.3125 -0.464705871468559 1575080.0 -52962.5 -0.255364547253857 -1.2677 -0.8369 2070135 Maybridge1_001262 O=C1NCCCCC1N2CNC(=S)NC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B09 compound treatment 1733210.0 -87100.0 -0.43 1617180.0 -14400.0 -0.06 1774210.0 -38665.3125 -0.201535917906369 1573720.0 -54322.5 -0.261921937563325 -0.4768 -0.8777 2070136 Maybridge1_001263 CN1N=C(C)/C(=C\c2c(C)nn(C)c2O)/C1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B10 compound treatment 1730720.0 -89600.0 -0.44 1552010.0 -79500.0 -0.35 1769980.0 -42895.3125 -0.223584024532791 1524960.0 -103082.5 -0.497023666599871 -0.7559 -0.9649 2070137 Maybridge1_001264 Clc1ccc(cc1Cl)C(=O)NNC(=O)c2cnn(n2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B11 compound treatment 1536160.0 -284000.0 -1.39 1539580.0 -92000.0 -0.41 1697520.0 -115355.3125 -0.601268612275241 1553060.0 -74982.5 -0.361536410940992 -1.3806 -0.8575 2070138 Maybridge1_001265 Cc1nn(C)c2oc(=O)c(Cl)c(C)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B12 compound treatment 1076080.0 -744000.0 -3.64 1158910.0 -473000.0 -2.1 1284020.0 -528855.3125 -2.75656225057917 941090.0 -686952.5 -3.31221740188633 -5.9034 -0.9808 2070139 Maybridge1_001266 Cc1ccc(cc1)S(=O)(=O)Oc2cc(ccc2[N+](=O)[O-])S(=O)(=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B13 compound treatment 1696560.0 -124000.0 -0.61 1306120.0 -325000.0 -1.44 1732860.0 -80015.3125 -0.417065281736762 1608870.0 -19172.5 -0.0924423277266852 -1.2792 -0.7885 2070140 Maybridge1_001267 Clc1ccc(cc1)c2nnnn2c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B14 compound treatment 1754080.0 -66200.0 -0.32 1342690.0 -289000.0 -1.28 1770950.0 -41925.3125 -0.218528075731933 1588320.0 -39722.5 -0.191526423946969 -1.0076 -0.7447 1063878 Maybridge1_001268 Cc1ccc(C)c(c1)C(O)C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B15 compound treatment 1657280.0 -163000.0 -0.8 1366720.0 -265000.0 -1.17 1655700.0 -157175.3125 -0.819247765730792 1436510.0 -191532.5 -0.923495117241431 -1.8575 -0.9873 2070141 Maybridge1_001269 Cc1cc(SCC#N)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B16 compound treatment 1732560.0 -87800.0 -0.43 1583580.0 -48000.0 -0.21 1799130.0 -13745.3125 -0.0716449445894789 1552800.0 -75242.5 -0.362790029676626 -0.5383 -0.8893 2070142 Maybridge1_001270 CC(C)(C)c1cc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)ccc1Oc3ccc(cc3[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B17 compound treatment 1529570.0 -291000.0 -1.42 1331060.0 -300000.0 -1.33 1699850.0 -113025.3125 -0.589123910516478 1540330.0 -87712.5 -0.42291551288183 -1.8837 -0.9057 1085663 Maybridge1_001271 Cc1cc(ccc1S(=O)(=O)N)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B18 compound treatment 1698880.0 -121000.0 -0.59 1365280.0 -266000.0 -1.18 1662240.0 -150635.3125 -0.785159203712635 1644360.0 16317.5 0.0786766296873223 -1.2408 -0.806 2070143 Maybridge1_001272 Cc1cc(c(C)cc1Cl)S(=O)(=O)c2ccc(cc2[N+](=O)[O-])C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B19 compound treatment 1494080.0 -326000.0 -1.6 1574980.0 -56600.0 -0.25 1692320.0 -120555.3125 -0.628372667702521 1549290.0 -78752.5 -0.379713882607682 -1.4277 -0.8043 2070144 Maybridge1_001273 CCCCCSc1ncccc1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B20 compound treatment 1632740.0 -188000.0 -0.92 1376160.0 -255000.0 -1.13 1786560.0 -26315.3125 -0.137163786266578 1568390.0 -59652.5 -0.287621121643817 -1.2377 -0.8294 1382605 Maybridge1_001274 COC(=O)c1ccccc1NS(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B21 compound treatment 1571700.0 -249000.0 -1.22 1263700.0 -368000.0 -1.63 1709440.0 -103435.3125 -0.539137777526552 1518680.0 -109362.5 -0.527303380675948 -1.9572 -0.9018 1166413 Maybridge1_001275 CCCSc1ncccc1C(=O)N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B22 compound treatment 1736910.0 -83400.0 -0.41 1412750.0 -219000.0 -0.97 1701330.0 -111545.3125 -0.581409679356406 1576730.0 -51312.5 -0.247408889893104 -1.1037 -0.8989 1543350 Maybridge1_001276 COc1cccc(c1)C(=O)NN 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B23 mock treatment 1724500.0 -95800.0 -0.47 1692800.0 61200.0 0.27 1858810.0 45934.6875 0.239426214622078 1666440.0 38397.5 0.185137790005758 0.1136 0.1831 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 B24 mock treatment 1596320.0 -224000.0 -1.1 1603010.0 -28500.0 -0.13 1762130.0 -50745.3125 -0.264500723591282 1673600.0 45557.5 0.219660521340903 -0.6338 -0.5484 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C01 compound treatment 1111460.0 -709000.0 -3.47 1213480.0 -418000.0 -1.85 1246480.0 -566395.3125 -2.95223268149073 1205780.0 -422262.5 -2.03598531290595 -5.1555 -0.9686 2070145 Maybridge1_001277 CSC1=NC=C(C#N)C2=NC(C)(NN21)c3ccc(Br)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C02 compound treatment 1544810.0 -276000.0 -1.35 1555520.0 -76000.0 -0.34 1568110.0 -244765.3125 -1.27579473012992 1572090.0 -55952.5 -0.269781162713645 -1.6155 -0.8477 2070146 Maybridge1_001278 Brc1csc(/C=C/2\N=C(OC2=O)c3ccccc3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C03 compound treatment 1052680.0 -768000.0 -3.76 1280070.0 -351000.0 -1.56 1338250.0 -474625.3125 -2.47389822638275 1269080.0 -358962.5 -1.73077736688435 -4.7599 -0.9397 2070147 Maybridge1_001279 CS/C(=N/N=C/c1ccc2OCOc2c1)/N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C04 compound treatment 793010.0 -1030000.0 -5.03 737550.0 -894000.0 -3.96 961180.0 -851695.3125 -4.43930710714517 901690.0 -726352.5 -3.50218885644006 -8.4666 -0.9912 2070148 Maybridge1_001280 COC(OC)/C(=N/NC(=S)N)/C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C05 compound treatment 1305700.0 -515000.0 -2.52 1578400.0 -53200.0 -0.24 1505410.0 -307465.3125 -1.60260709076271 1557080.0 -70962.5 -0.342153536643886 -2.3494 -0.7796 2070149 Maybridge1_001281 CCCc1nc2cc(Cl)c(Cl)cc2nc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C06 compound treatment 1401310.0 -419000.0 -2.05 1568640.0 -62900.0 -0.28 1671970.0 -140905.3125 -0.734443346153513 1558770.0 -69272.5 -0.334005014862266 -1.6989 -0.7649 2070150 Maybridge1_001282 OCCCc1nc2cc(Cl)ccc2[nH]1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C07 compound treatment 1677650.0 -143000.0 -0.7 1585160.0 -46400.0 -0.21 1706120.0 -106755.3125 -0.5564426744532 1576440.0 -51602.5 -0.248807156944388 -0.8546 -0.9002 2070151 Maybridge1_001283 N/C(=N\O)/CC(=O)Nc1cc(Cl)cc(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C08 compound treatment 706600.0 -1110000.0 -5.45 675360.0 -956000.0 -4.24 815860.0 -997015.3125 -5.19676120997063 812210.0 -815832.5 -3.93362656591894 -9.4104 -0.991 2070152 Maybridge1_001284 CCOC(=O)c1cc(CC)sc1NC(=O)C(Cl)Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C09 compound treatment 279360.0 -1540000.0 -7.54 452090.0 -1180000.0 -5.23 582340.0 -1230535.3125 -6.41394179138958 523680.0 -1104362.5 -5.32480584973589 -12.255 -0.9885 2070153 Maybridge1_001285 Cc1cc(Oc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])ccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C10 compound treatment 950600.0 -870000.0 -4.26 1031570.0 -600000.0 -2.66 974680.0 -838195.3125 -4.36894080940127 1012440.0 -615602.5 -2.9681954911653 -7.1269 -0.9781 2070154 Maybridge1_001286 [O-][N+](=O)c1cnc(s1)n2cccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C11 compound treatment 1616870.0 -203000.0 -1.0 1311640.0 -320000.0 -1.42 1682590.0 -130285.3125 -0.679088525261644 1562400.0 -65642.5 -0.31650256866861 -1.705 -0.9029 1249008 Maybridge1_001287 COc1ccc(cc1OC)S(=O)(=O)Nc2ccc3oc4ncccc4c(=O)c3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C12 compound treatment 1338760.0 -482000.0 -2.36 1407650.0 -224000.0 -0.99 1595610.0 -217265.3125 -1.13245597546642 1514560.0 -113482.5 -0.547168416025221 -2.5145 -0.8824 2070155 Maybridge1_001288 CCc1nnc(N/C=N/O)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C13 compound treatment 1547930.0 -272000.0 -1.33 1449040.0 -183000.0 -0.81 1446900.0 -365975.3125 -1.90757983750313 1284560.0 -343482.5 -1.65613883600893 -2.853 -0.961 2070156 Maybridge1_001289 CN(C)/C=N/S(=O)(=O)c1cc(Cl)c(Oc2ccc(cc2)[N+](=O)[O-])c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C14 compound treatment 1772420.0 -47900.0 -0.23 1613300.0 -18300.0 -0.08 1749220.0 -63655.3125 -0.331791753507857 1498600.0 -129442.5 -0.624121319951047 -0.6357 -0.8486 2070157 Maybridge1_001290 Cc1cc(NC(=O)NC(=O)c2c(Cl)cccc2Cl)no1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C15 compound treatment 1675770.0 -145000.0 -0.71 1461120.0 -170000.0 -0.76 1860200.0 47324.6875 0.246671337130524 1552710.0 -75332.5 -0.363223974623576 -0.7899 -0.7024 2070158 Maybridge1_001291 [O-][N+](=O)c1cc(cc(Br)c1OC(=O)c2ccccc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C16 compound treatment 1626610.0 -194000.0 -0.95 1406080.0 -225000.0 -1.0 1690690.0 -122185.3125 -0.636868746615303 1556520.0 -71522.5 -0.34485363853602 -1.4648 -0.941 2070159 Maybridge1_001292 Cc1cc(OS(=O)(=O)c2ccc(F)c(Cl)c2)n(n1)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C17 compound treatment 1670470.0 -150000.0 -0.73 1502170.0 -129000.0 -0.57 1794820.0 -18055.3125 -0.0941100366840132 1529300.0 -98742.5 -0.476097876935831 -0.9387 -0.894 2070160 Maybridge1_001293 FC(F)(F)c1cc(Br)c2ncc(nc2c1)c3ccc(Br)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C18 compound treatment 1817950.0 -2380.0 -0.01 1513630.0 -118000.0 -0.52 1829980.0 17104.6875 0.0891550765512135 1543260.0 -84782.5 -0.408788194053341 -0.4271 -0.6376 2070161 Maybridge1_001294 Fc1cccc(Cl)c1C(=O)NC(=O)NCC2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C19 compound treatment 1694410.0 -126000.0 -0.62 1310180.0 -321000.0 -1.43 1617790.0 -195085.3125 -1.01684675443237 1484170.0 -143872.5 -0.69369715977872 -1.876 -0.9468 2070162 Maybridge1_001295 COCCCNC(=S)NNC(=O)c1cc(OC)c(OC)c(OC)c1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C20 compound treatment 1753360.0 -67000.0 -0.33 1349440.0 -282000.0 -1.25 1708740.0 -104135.3125 -0.542786400372532 1523730.0 -104312.5 -0.502954247541523 -1.3123 -0.8807 2070163 Maybridge1_001296 Oc1cc(ccc1[N+](=O)[O-])N2CCOCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C21 compound treatment 1634500.0 -186000.0 -0.91 1280510.0 -351000.0 -1.56 1579090.0 -233785.3125 -1.21856347463155 1413540.0 -214502.5 -1.03424751092415 -2.3595 -0.9793 2070164 Maybridge1_001297 Brc1csc(/C=C\2/SC(=S)NC2=O)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C22 compound treatment 1652850.0 -167000.0 -0.82 1328100.0 -303000.0 -1.35 1683270.0 -129605.3125 -0.675544148782692 1507130.0 -120912.5 -0.582992982201217 -1.7119 -0.9454 2070165 Maybridge1_001298 [O-][N+](=O)c1ccc(nc1)N2CCN(CC2)C(=O)c3c(F)cccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C23 mock treatment 1752540.0 -67800.0 -0.33 1396590.0 -235000.0 -1.04 1801560.0 -11315.3125 -0.0589790109955767 1679290.0 51247.5 0.247095485209196 -0.5928 -0.528 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 C24 mock treatment 1763970.0 -56400.0 -0.28 1430450.0 -201000.0 -0.89 1842290.0 29414.6875 0.153318715456948 1603210.0 -24832.5 -0.119732643279328 -0.567 -0.5946 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D01 compound treatment 1316160.0 -504000.0 -2.47 1531930.0 -99600.0 -0.44 1477510.0 -335365.3125 -1.74803077276677 998730.0 -629312.5 -3.03429977141737 -3.8456 -0.893 1295753 Maybridge1_001299 Cc1cc(c(C)cc1Cl)S(=O)(=O)NN 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D02 compound treatment 1590620.0 -230000.0 -1.12 1514400.0 -117000.0 -0.52 1572930.0 -239945.3125 -1.25067135567618 1281970.0 -346072.5 -1.66862680726005 -2.2815 -0.9407 2070166 Maybridge1_001300 CCCC1=NN(C(=O)C1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D03 compound treatment 1449830.0 -370000.0 -1.81 1497770.0 -134000.0 -0.59 1468000.0 -344875.3125 -1.79759992028859 1373090.0 -254952.5 -1.22928165652563 -2.7166 -0.9383 2070167 Maybridge1_001301 [O-][N+](=O)c1cc(ccc1NCC2CC2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D04 compound treatment 1457280.0 -363000.0 -1.78 1550980.0 -80600.0 -0.36 1434320.0 -378555.3125 -1.97315080236374 1445190.0 -182852.5 -0.88164353791335 -2.4943 -0.8844 2070168 Maybridge1_001302 CSc1ncccc1C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D05 compound treatment 749400.0 -1070000.0 -5.24 803440.0 -828000.0 -3.67 796190.0 -1016685.3125 -5.29928751194267 697680.0 -930362.5 -4.48584561896561 -9.3491 -0.9901 2070169 Maybridge1_001303 CN(C)/C=N/c1nnc(Sc2nc3c(Cl)cc(Cl)cc3s2)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D06 compound treatment 1587730.0 -233000.0 -1.14 1650130.0 18600.0 0.08 1669120.0 -143755.3125 -0.749298453455003 1586670.0 -41372.5 -0.199482081307721 -1.0023 -0.7265 2070170 Maybridge1_001304 Clc1cc(Cl)cc(c1)S(=O)(=O)Oc2ccc(OCc3ccccc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D07 compound treatment 1513820.0 -307000.0 -1.5 1731840.0 100000.0 0.44 1551520.0 -261355.3125 -1.36226709157965 1548380.0 -79662.5 -0.3841015481824 -1.4008 -0.664 2070171 Maybridge1_001305 Clc1cc(Cl)cc(OS(=O)(=O)c2cccc(c2)S(=O)(=O)Oc3cc(Cl)cc(Cl)c3)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D08 compound treatment 1646140.0 -174000.0 -0.85 1364080.0 -267000.0 -1.19 1583680.0 -229195.3125 -1.19463893339863 1561570.0 -66472.5 -0.320504505401595 -1.7769 -0.9283 2070172 Maybridge1_001306 CCCc1cc(O)nc(SCC(=O)Nc2ccc(F)c(Cl)c2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D09 compound treatment 1592580.0 -228000.0 -1.11 1374010.0 -258000.0 -1.14 1474520.0 -338355.3125 -1.76361560463746 1326320.0 -301722.5 -1.45478838062406 -2.7375 -0.9819 1009028 Maybridge1_001307 Clc1ccc(NC(=O)c2ccccc2Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D10 compound treatment 1353810.0 -467000.0 -2.28 1498950.0 -133000.0 -0.59 1498530.0 -314345.3125 -1.63846784102034 1468330.0 -159712.5 -0.770071470441946 -2.6397 -0.8881 2070173 Maybridge1_001308 Cc1cc(OC(=O)c2nn(nc2C)c3ccccc3)n(n1)c4cccc(Cl)c4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D11 compound treatment 1318430.0 -502000.0 -2.46 1593720.0 -37800.0 -0.17 1709770.0 -103105.3125 -0.53741771247059 1432840.0 -195202.5 -0.941190427855954 -2.0512 -0.7626 1258378 Maybridge1_001309 CCOC(=O)Cc1csc(NS(=O)(=O)c2ccc(Cl)cc2)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D12 compound treatment 1779370.0 -41000.0 -0.2 1521980.0 -110000.0 -0.49 1641410.0 -171465.3125 -0.893731794972299 1414660.0 -213382.5 -1.02884730713988 -1.3045 -0.8931 2070174 Maybridge1_001310 FC(F)(F)c1cccc(Sc2ncccc2C(=O)Nc3ccc(Cl)cc3Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D13 compound treatment 1421520.0 -399000.0 -1.95 1425250.0 -206000.0 -0.91 1651570.0 -161305.3125 -0.840774640522074 1469190.0 -158852.5 -0.765924885393311 -2.2366 -0.9177 2070175 Maybridge1_001311 Cc1cc(SCc2c(Cl)cccc2Cl)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D14 compound treatment 1601180.0 -219000.0 -1.07 1522130.0 -109000.0 -0.49 1724520.0 -88355.3125 -0.460536016787439 1592280.0 -35762.5 -0.172432846281162 -1.0953 -0.8586 2070176 Maybridge1_001312 CN(C(=O)CSc1ccc(Cl)cc1)c2ccc(F)cc2F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D15 compound treatment 1652020.0 -168000.0 -0.82 1601240.0 -30300.0 -0.13 1809790.0 -3085.3125 -0.016081630963554 1663370.0 35327.5 0.170335445704236 -0.4019 -0.4718 2070177 Maybridge1_001313 CC(=O)NCCSc1cc(C)c(Cl)cc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D16 compound treatment 1685180.0 -135000.0 -0.66 1384710.0 -247000.0 -1.09 1638350.0 -174525.3125 -0.909681489127583 1563130.0 -64912.5 -0.312982792987793 -1.4893 -0.9306 2070178 Maybridge1_001314 Cc1ccc([N+](=O)[O-])c(NC(=O)NC(=O)c2c(Cl)cccc2Cl)c1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D17 compound treatment 1692090.0 -128000.0 -0.63 1708540.0 77000.0 0.34 1649440.0 -163435.3125 -0.851876878610556 1568270.0 -59772.5 -0.288199714906418 -0.7131 -0.6209 2070179 Maybridge1_001315 COc1cc(cc(Br)c1O)C2SCCS2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D18 compound treatment 1758880.0 -61400.0 -0.3 1690880.0 59300.0 0.26 1608510.0 -204365.3125 -1.06521706873336 1588960.0 -39082.5 -0.188440593213101 -0.6456 -0.5599 2070180 Maybridge1_001316 OC(=O)c1ccc(c(c1)[N+](=O)[O-])S(=O)(=O)c2cc(Cl)ccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D19 compound treatment 1569710.0 -251000.0 -1.23 1546400.0 -85200.0 -0.38 1792800.0 -20075.3125 -0.104638919753841 1562020.0 -66022.5 -0.318334780666844 -1.0135 -0.7642 1469626 Maybridge1_001317 OC(=O)c1cccnc1SCC=C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D20 compound treatment 1609240.0 -211000.0 -1.03 1333960.0 -298000.0 -1.32 1670240.0 -142635.3125 -0.743460656901435 1382170.0 -245872.5 -1.18550143298889 -2.1408 -0.9805 2070181 Maybridge1_001318 CSC(=NS(=O)(=O)c1ccc(cc1)n2nc(cc2c3cccs3)C(F)(F)F)SC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D21 compound treatment 1749820.0 -70500.0 -0.35 1371520.0 -260000.0 -1.15 1673630.0 -139245.3125 -0.725790897690188 1458950.0 -169092.5 -0.815298177135195 -1.5197 -0.9352 1678057 Maybridge1_001319 CCSc1ncccc1C(=O)N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D22 compound treatment 1260680.0 -560000.0 -2.74 1176480.0 -455000.0 -2.02 1514300.0 -298575.3125 -1.55626958061876 1309500.0 -318542.5 -1.53588786959852 -3.9244 -0.9704 2070182 Maybridge1_001320 Nc1ccccc1C(=O)NNC(=O)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D23 mock treatment 1726940.0 -93400.0 -0.46 1516000.0 -116000.0 -0.51 1690170.0 -122705.3125 -0.639579152158031 1514030.0 -114012.5 -0.549723869601705 -1.0794 -0.9925 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 D24 mock treatment 1831370.0 11000.0 0.05 1699140.0 67600.0 0.3 1848770.0 35894.6875 0.187094538374021 1711580.0 83537.5 0.402785288953864 0.4718 0.8762 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E01 compound treatment 1224890.0 -595000.0 -2.91 1087570.0 -544000.0 -2.41 1253470.0 -559405.3125 -2.91579857621444 1243430.0 -384612.5 -1.85445167676514 -5.0482 -0.9853 2070183 Maybridge1_001321 C/C(=N\Nc1nc(cs1)C(C)(C)C)/c2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E02 compound treatment 1651480.0 -169000.0 -0.83 1467810.0 -164000.0 -0.73 1463400.0 -349475.3125 -1.82157658470503 1568440.0 -59602.5 -0.287380041117734 -1.8307 -0.8526 2070184 Maybridge1_001322 Nc1ccccc1C(=O)NCCCN2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E03 compound treatment 1169560.0 -651000.0 -3.18 1279880.0 -352000.0 -1.56 1349440.0 -463435.3125 -2.41557238403058 1322030.0 -306012.5 -1.47547308976202 -4.3176 -0.9516 2070185 Maybridge1_001323 CS/C(=N/N=C/c1cccs1)/N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E04 compound treatment 1551360.0 -269000.0 -1.32 1595040.0 -36500.0 -0.16 1444930.0 -367945.3125 -1.91784810465539 1579260.0 -48782.5 -0.235210215273283 -1.8156 -0.7747 1582393 Maybridge1_001324 COC(=O)c1cc(OC)c(OC)c(OC)c1NS(=O)(=O)c2cc(Cl)cc(Cl)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E05 compound treatment 1210130.0 -610000.0 -2.99 1345610.0 -286000.0 -1.27 1408640.0 -404235.3125 -2.10700313762769 1299360.0 -328682.5 -1.58477900028824 -3.9729 -0.9504 2070186 Maybridge1_001325 CCCc1nc2cc(C)c(C)cc2nc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E06 compound treatment 1508640.0 -312000.0 -1.53 1702350.0 70800.0 0.31 1677040.0 -135835.3125 -0.708016892111914 1525040.0 -103002.5 -0.496637937758138 -1.208 -0.6782 1004703 Maybridge1_001326 OC(=O)c1ccccc1I 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E07 compound treatment 1644960.0 -175000.0 -0.86 1597150.0 -34400.0 -0.15 1547970.0 -264905.3125 -1.38077082172712 1503600.0 -124442.5 -0.600013267342706 -1.4958 -0.8598 2070187 Maybridge1_001327 Cc1ccc(NC(=O)C/C(=N/O)/N)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E08 compound treatment 1201010.0 -619000.0 -3.03 1177480.0 -454000.0 -2.01 1273800.0 -539075.3125 -2.80983214413048 1388320.0 -239722.5 -1.15584852828063 -4.505 -0.9504 2070188 Maybridge1_001328 CCOC(=O)c1cc(CC)sc1NC(=O)C(Cl)(Cl)Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E09 compound treatment 1432380.0 -388000.0 -1.9 1577040.0 -54500.0 -0.24 1457940.0 -354935.3125 -1.85003584290367 1514630.0 -113412.5 -0.546830903288705 -2.2685 -0.8348 1222255 Maybridge1_001329 Fc1ccc(NC(=O)Cc2ncon2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E10 compound treatment 1242600.0 -578000.0 -2.83 1461790.0 -170000.0 -0.75 1646950.0 -165925.3125 -0.864855551305542 1600320.0 -27722.5 -0.133667097686949 -2.2892 -0.7497 1363938 Maybridge1_001330 CCOC(=O)c1c(O)c2ccccc2n(C)c1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E11 compound treatment 1455260.0 -365000.0 -1.79 1579610.0 -51900.0 -0.23 1616000.0 -196875.3125 -1.02617680428137 1592870.0 -35172.5 -0.169588096073378 -1.6063 -0.7723 2070189 Maybridge1_001331 NS(=O)(=O)c1ccc(Oc2c(Cl)cccc2[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E12 compound treatment 1633090.0 -187000.0 -0.92 1686620.0 55100.0 0.24 1736320.0 -76555.3125 -0.399030660240918 1664110.0 36067.5 0.173903437490271 -0.4486 -0.4299 2070190 Maybridge1_001332 CN(C)/C=N/c1nnc(s1)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E13 compound treatment 1796870.0 -23500.0 -0.11 1622460.0 -9100.0 -0.04 1812000.0 -875.3125 -0.00456240740695988 1516560.0 -111482.5 -0.537525194981885 -0.3486 -0.6325 2070191 Maybridge1_001333 FC(F)(F)c1ccc2nc(cnc2c1)c3ccc(Cl)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E14 compound treatment 1723450.0 -96900.0 -0.47 1507080.0 -124000.0 -0.55 1716510.0 -96365.3125 -0.502286686782153 1562780.0 -65262.5 -0.314670356670377 -0.9215 -0.9819 2070192 Maybridge1_001334 Cc1cc(NC(=O)NC(=O)c2c(F)cccc2Cl)no1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E15 compound treatment 1775110.0 -45200.0 -0.22 1441600.0 -190000.0 -0.84 1639220.0 -173655.3125 -0.905146772161865 1541790.0 -86252.5 -0.415875961520194 -1.1923 -0.9011 2070193 Maybridge1_001335 CC(=O)OCc1csc(n1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E16 compound treatment 1778490.0 -41800.0 -0.2 1505510.0 -126000.0 -0.56 1766180.0 -46695.3125 -0.243390834268111 1538170.0 -89872.5 -0.433330191608633 -0.7202 -0.9287 2070194 Maybridge1_001336 CN(C)/C=N/c1nnc(Sc2ccc(cc2[N+](=O)[O-])C(F)(F)F)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E17 compound treatment 1802280.0 -18000.0 -0.09 1351460.0 -280000.0 -1.24 1695880.0 -116995.3125 -0.609816814371537 1592880.0 -35162.5 -0.169539879968161 -1.0549 -0.7552 2070195 Maybridge1_001337 CC(O)CNc1ccc(cc1[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E18 compound treatment 1762880.0 -57400.0 -0.28 1400650.0 -231000.0 -1.02 1555940.0 -256935.3125 -1.33922864446646 1335410.0 -292632.5 -1.41095994098209 -2.0277 -0.9149 1525564 Maybridge1_001338 Clc1cc(Cl)cc(c1)S(=O)(=O)NCC2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E19 compound treatment 1784340.0 -36000.0 -0.18 1441850.0 -190000.0 -0.84 1768360.0 -44515.3125 -0.232027980262059 1604350.0 -23692.5 -0.114236007284626 -0.6818 -0.7596 1055254 Maybridge1_001339 OCCNc1ccc(cn1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E20 compound treatment 1775680.0 -44600.0 -0.22 1351130.0 -280000.0 -1.24 1690170.0 -122705.3125 -0.639579152158031 1441990.0 -186052.5 -0.897072691582689 -1.4994 -0.8948 2070196 Maybridge1_001340 CC1CN(CC(C)O1)c2ccc([N+](=O)[O-])c(O)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E21 compound treatment 1391450.0 -429000.0 -2.1 1166210.0 -465000.0 -2.06 1605060.0 -207815.3125 -1.08319956704569 1233600.0 -394442.5 -1.90184810819314 -3.5737 -0.9743 2070197 Maybridge1_001341 C/C(=N\Nc1c(Cl)cc(Cl)cc1Cl)/C(=N\O)/C(=O)Nc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E22 compound treatment 1620210.0 -200000.0 -0.98 1141300.0 -490000.0 -2.17 1621610.0 -191265.3125 -0.99693569833002 1392160.0 -235882.5 -1.13733354387742 -2.6438 -0.9363 2070198 Maybridge1_001342 [O-][N+](=O)c1ccc(nc1)N2CCN(CC2)C(=O)c3ccccc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E23 mock treatment 1787100.0 -33200.0 -0.16 1286490.0 -345000.0 -1.53 1755360.0 -57515.3125 -0.29978811883026 1492870.0 -135172.5 -0.651749148240206 -1.3222 -0.7787 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 E24 mock treatment 1811400.0 -8930.0 -0.04 1377280.0 -254000.0 -1.13 1902490.0 89614.6875 0.467100280211233 1514730.0 -113312.5 -0.546348742236538 -0.6253 -0.4673 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F01 compound treatment 1530400.0 -290000.0 -1.42 1623130.0 -8430.0 -0.04 1558050.0 -254825.3125 -1.32823065274501 1066300.0 -561742.5 -2.70850354846825 -2.7464 -0.8238 2070199 Maybridge1_001343 N/C(=N\O)/CS(=O)(=O)c1ccccc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F02 compound treatment 1285340.0 -535000.0 -2.62 1531970.0 -99600.0 -0.44 1527840.0 -285035.3125 -1.48569479014081 1187290.0 -440752.5 -2.1251368914516 -3.3352 -0.8987 1573123 Maybridge1_001344 Clc1ccc(cc1)C(=O)N2CCN(CC2)C(=O)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F03 compound treatment 1361250.0 -459000.0 -2.25 1642360.0 10800.0 0.05 1479270.0 -333605.3125 -1.73885709246831 1453920.0 -174122.5 -0.839550878059186 -2.3885 -0.8062 1428169 Maybridge1_001345 Cc1cc(O)c2cc(F)cc(F)c2n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F04 compound treatment 1382800.0 -438000.0 -2.14 1559140.0 -72400.0 -0.32 1275530.0 -537345.3125 -2.80081483338256 1470840.0 -157202.5 -0.757969228032559 -3.0105 -0.8316 1002355 Maybridge1_001346 CC(=O)Nc1ccc(cc1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F05 compound treatment 75520.0 -1740000.0 -8.54 80840.0 -1550000.0 -6.88 86840.0 -1726035.3125 -8.99664553450832 88800.0 -1539242.5 -7.421627833399 -15.9167 -0.9944 1357459 Maybridge1_001347 Cc1cc(Sc2nnc(N)s2)c3ccccc3n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F06 compound treatment 1185140.0 -635000.0 -3.11 1329630.0 -302000.0 -1.34 1346330.0 -466545.3125 -2.43178269410343 1324740.0 -303302.5 -1.4624065252483 -4.1707 -0.9443 2070200 Maybridge1_001348 [O-][N+](=O)c1cccnc1Oc2ccc(OCc3ccccc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F07 compound treatment 1795550.0 -24800.0 -0.12 1691310.0 59800.0 0.26 1515770.0 -297105.3125 -1.5486074726422 1678600.0 50557.5 0.243768573949244 -0.5805 -0.3641 1567712 Maybridge1_001349 Cc1cc(C)c2nc(C)cc(O)c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F08 compound treatment 1530890.0 -289000.0 -1.42 1475730.0 -156000.0 -0.69 1428650.0 -384225.3125 -2.00270464741618 1560640.0 -67402.5 -0.324988603186747 -2.2175 -0.8632 1275354 Maybridge1_001350 O=C(Nc1ccccc1C(=O)NC2CCCCNC2=O)c3cccs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F09 compound treatment 1587690.0 -233000.0 -1.14 1176580.0 -455000.0 -2.02 1461490.0 -351385.3125 -1.8315321127562 1296810.0 -331232.5 -1.59707410711849 -3.2924 -0.9806 2070201 Maybridge1_001351 Clc1ccc(/C=C/2\C(=O)ON=C2c3ccccc3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F10 compound treatment 1562800.0 -258000.0 -1.26 1407480.0 -224000.0 -0.99 1717350.0 -95525.3125 -0.497908339366977 1481790.0 -146252.5 -0.705172592820291 -1.7285 -0.9485 1686372 Maybridge1_001352 O=C(CC#N)NC1CCCCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F11 compound treatment 1353170.0 -467000.0 -2.29 1384810.0 -247000.0 -1.09 1572110.0 -240765.3125 -1.25494545672432 1500800.0 -127242.5 -0.613513776803377 -2.6244 -0.9069 1741154 Maybridge1_001353 CCOC(=O)Cc1csc(NS(=O)(=O)c2ccc(F)cc2F)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F12 compound treatment 1835690.0 15400.0 0.08 1662050.0 30500.0 0.14 1620410.0 -192465.3125 -1.0031904803517 1589480.0 -38562.5 -0.185933355741833 -0.4894 -0.4742 2070202 Maybridge1_001354 [O-][N+](=O)c1ccc(cc1OC(=O)c2ccc(Cl)c(Cl)c2)S(=O)(=O)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F13 compound treatment 1624900.0 -195000.0 -0.96 1515490.0 -116000.0 -0.51 1710140.0 -102735.3125 -0.535489154680572 1521130.0 -106912.5 -0.515490434897861 -1.261 -0.9582 2070203 Maybridge1_001355 Cc1cc(SCc2cccc(F)c2)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F14 compound treatment 1649530.0 -171000.0 -0.84 1498340.0 -133000.0 -0.59 1457960.0 -354915.3125 -1.84993159653664 1495460.0 -132582.5 -0.639261176989086 -1.9579 -0.8864 2070204 Maybridge1_001356 Clc1ccc(cc1)C(=O)Nc2ncccn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F15 compound treatment 79200.0 -1740000.0 -8.52 79730.0 -1550000.0 -6.88 73920.0 -1738955.3125 -9.0639886876084 72730.0 -1555312.5 -7.49911111448221 -15.9826 -0.9944 2070205 Maybridge1_001357 Clc1cn[nH]c(=O)c1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F16 compound treatment 1530240.0 -290000.0 -1.42 1323220.0 -308000.0 -1.37 1609490.0 -203385.3125 -1.06010899674899 1404170.0 -223872.5 -1.07942600151218 -2.4632 -0.9914 2070206 Maybridge1_001358 OC(=O)c1ccc(Sc2ccc(Cl)cc2)c(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F17 compound treatment 1859520.0 39200.0 0.19 1599840.0 -31700.0 -0.14 1762820.0 -50055.3125 -0.260904223928816 1649870.0 21827.5 0.105243703661715 -0.0523 -0.1419 2070207 Maybridge1_001359 CCOC(=O)CC(=O)CSc1cc(C)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F18 compound treatment 1826920.0 6590.0 0.03 1527310.0 -104000.0 -0.46 1796890.0 -15985.3125 -0.083320537696615 1491280.0 -136762.5 -0.659415508969659 -0.5864 -0.7237 1863471 Maybridge1_001360 OC(=O)c1ccc(Sc2ccccn2)c(c1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F19 compound treatment 1732350.0 -88000.0 -0.43 1427950.0 -204000.0 -0.9 1690180.0 -122695.3125 -0.639527028974517 1651440.0 23397.5 0.112813632180734 -0.9301 -0.7799 2070208 Maybridge1_001361 CN(C)/C=C\1/C(=O)NN=C1CSc2cc(C)c(Cl)cc2C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F20 compound treatment 1696980.0 -123000.0 -0.6 1318400.0 -313000.0 -1.39 1581160.0 -231715.3125 -1.20777397564415 1533620.0 -94422.5 -0.455268519482224 -1.8277 -0.9186 2070209 Maybridge1_001362 FC(F)(F)c1cc(c2cccs2)n(n1)c3ccc(cc3)S(=O)(=O)NC(=S)Nc4ccc(Cl)cc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F21 compound treatment 1684170.0 -136000.0 -0.67 1351420.0 -280000.0 -1.24 1621180.0 -191695.3125 -0.999176995221122 1587210.0 -40832.5 -0.19687841162602 -1.5523 -0.8926 1783937 Maybridge1_001363 [O-][N+](=O)c1ccc(cc1)C(=O)N2CCNCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F22 compound treatment 1616090.0 -204000.0 -1.0 1482280.0 -149000.0 -0.66 1744800.0 -68075.3125 -0.354830200621045 1656180.0 28137.5 0.135668066053441 -0.9403 -0.7477 2070210 Maybridge1_001364 COc1ccc(Br)c(c1)C(=O)NNC(=O)c2ccccc2N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F23 mock treatment 1741320.0 -79000.0 -0.39 1599200.0 -32400.0 -0.14 1821690.0 8814.6875 0.0459449574181069 1674080.0 46037.5 0.221974894391304 -0.1311 -0.2786 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 F24 mock treatment 1923520.0 103000.0 0.5 1749970.0 118000.0 0.53 1775070.0 -37805.3125 -0.197053324124165 1677280.0 49237.5 0.237404048060642 0.5352 0.6765 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G01 compound treatment 1324360.0 -496000.0 -2.43 1329720.0 -302000.0 -1.34 1333080.0 -479795.3125 -2.50084591225948 1317790.0 -310252.5 -1.49591671837389 -3.8812 -0.9651 2070211 Maybridge1_001365 CS/C(=N/N=C/c1ccc(Cl)cc1)/N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G02 compound treatment 1535620.0 -285000.0 -1.39 1629860.0 -1700.0 -0.01 1603400.0 -209475.3125 -1.09185201550902 1578570.0 -49472.5 -0.238537126533234 -1.3656 -0.7646 2070212 Maybridge1_001366 NS(=O)(=O)c1cc(Cl)cc(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G03 compound treatment 1461760.0 -359000.0 -1.75 1379930.0 -252000.0 -1.12 1350150.0 -462725.3125 -2.41187163800108 1497920.0 -130122.5 -0.627400015105782 -2.9549 -0.9104 2070213 Maybridge1_001367 [O-][N+](=O)c1ccc(Oc2ccc(cc2)c3ccc(Oc4ccc(cn4)[N+](=O)[O-])cc3)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G04 compound treatment 1350210.0 -470000.0 -2.3 1513450.0 -118000.0 -0.52 1414560.0 -398315.3125 -2.07614621298741 1377600.0 -250442.5 -1.20753619307291 -3.054 -0.9071 1737783 Maybridge1_001368 COC(=O)c1cc(OC)c(OC)c(OC)c1NC(=O)c2cc3ccccc3oc2=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G05 compound treatment 1467370.0 -353000.0 -1.73 1649950.0 18400.0 0.08 1558110.0 -254765.3125 -1.32791791364393 1450240.0 -177802.5 -0.857294404778925 -1.9154 -0.8176 2070214 Maybridge1_001369 [O-][N+](=O)c1cc(ccc1Oc2ccc(F)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G06 compound treatment 1433950.0 -386000.0 -1.89 1603170.0 -28400.0 -0.13 1607710.0 -205165.3125 -1.06938692341448 1561440.0 -66602.5 -0.321131314769412 -1.7036 -0.7746 2070215 Maybridge1_001370 CN(C)/C=N/c1cc(C)on1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G07 compound treatment 1681460.0 -139000.0 -0.68 1723550.0 92000.0 0.41 1646910.0 -165965.3125 -0.865064044039598 1627430.0 -612.5 -0.00295323644452183 -0.5698 -0.4856 2070216 Maybridge1_001371 CSc1ccc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G08 compound treatment 1455840.0 -364000.0 -1.78 1592050.0 -39500.0 -0.18 1622890.0 -189985.3125 -0.990263930840228 1437610.0 -190432.5 -0.918191345667596 -1.9336 -0.8617 1380289 Maybridge1_001372 Cc1nn(nc1C(=O)Nc2nnc(s2)C3CC3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G09 compound treatment 453290.0 -1370000.0 -6.69 539060.0 -1090000.0 -4.84 994270.0 -818605.3125 -4.26683149289734 780590.0 -847452.5 -4.08608589061409 -9.9437 -0.9792 2070217 Maybridge1_001373 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1Oc2ccc(Cl)cc2Cl)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G10 compound treatment 1455380.0 -365000.0 -1.79 1462640.0 -169000.0 -0.75 1499640.0 -313235.3125 -1.63268216765029 1362080.0 -265962.5 -1.2823675883692 -2.725 -0.9598 2070218 Maybridge1_001374 CSC(=S)Nc1ccc(F)cc1F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G11 compound treatment 873970.0 -946000.0 -4.63 905570.0 -726000.0 -3.22 927100.0 -885775.3125 -4.61694291656089 932750.0 -695292.5 -3.35242963363705 -7.9099 -0.9859 2070219 Maybridge1_001375 FC(F)(F)c1ccc2nc3C(=O)c4ccccc4-c3nc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G12 compound treatment 1893050.0 72700.0 0.36 1679570.0 48000.0 0.21 1680040.0 -132835.3125 -0.692379937057714 1561670.0 -66372.5 -0.320022344349428 -0.2218 -0.2555 2070220 Maybridge1_001376 CN(C)/C=N/c1nnc(C)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G13 compound treatment 1649760.0 -171000.0 -0.83 1586800.0 -44800.0 -0.2 1597570.0 -215305.3125 -1.12223983149768 1594910.0 -33132.5 -0.159752010609174 -1.1576 -0.8143 1052629 Maybridge1_001377 COc1cc(C(=O)O)c([N+](=O)[O-])c(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G14 compound treatment 1698520.0 -122000.0 -0.6 1462880.0 -169000.0 -0.75 1741720.0 -71155.3125 -0.370884141143357 1537640.0 -90402.5 -0.435885645185117 -1.0754 -0.9648 2070221 Maybridge1_001378 Cc1onc(NC(=O)NC(=O)c2c(F)cccc2Cl)c1Br 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G15 compound treatment 443040.0 -1380000.0 -6.74 571610.0 -1060000.0 -4.7 721060.0 -1091815.3125 -5.69088898968336 484870.0 -1143172.5 -5.51193255408184 -11.3215 -0.9919 2070222 Maybridge1_001379 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1Oc2ccc(cc2)C(F)(F)F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G16 compound treatment 593030.0 -1230000.0 -6.01 527680.0 -1100000.0 -4.9 578310.0 -1234565.3125 -6.43494743434572 571640.0 -1056402.5 -5.09356140911668 -11.2148 -0.9936 2070223 Maybridge1_001380 CN(C)/C=N/c1nnc(Sc2ccc(cn2)[N+](=O)[O-])s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G17 compound treatment 1587710.0 -233000.0 -1.14 1322570.0 -309000.0 -1.37 1592710.0 -220165.3125 -1.14757169868548 1120640.0 -507402.5 -2.44649723272079 -3.0513 -0.9428 1500459 Maybridge1_001381 COc1cc2c(=O)n(CC=C)c(=S)[nH]c2c(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G18 compound treatment 1448680.0 -372000.0 -1.82 1237920.0 -394000.0 -1.75 1457490.0 -355385.3125 -1.8523813861618 1237290.0 -390752.5 -1.88405636536819 -3.6504 -0.9996 1441622 Maybridge1_001382 Cc1cc(c(C)cc1Cl)S(=O)(=O)NCC2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G19 compound treatment 1435320.0 -385000.0 -1.88 1249000.0 -383000.0 -1.7 1469120.0 -343755.3125 -1.79176212373502 1313050.0 -314992.5 -1.5187711522466 -3.4455 -0.9969 2070224 Maybridge1_001383 [O-][N+](=O)c1ccc(o1)C(=O)OCCNc2ccc(cn2)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G20 compound treatment 1667800.0 -153000.0 -0.75 1447740.0 -184000.0 -0.82 1619610.0 -193265.3125 -1.00736033503282 1550670.0 -77372.5 -0.373060060087779 -1.471 -0.9544 2070225 Maybridge1_001384 Oc1cc(ccc1[N+](=O)[O-])N2CCCCC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G21 compound treatment 1640000.0 -180000.0 -0.88 1447590.0 -184000.0 -0.82 1421030.0 -391845.3125 -2.04242251325385 1575060.0 -52982.5 -0.25546097946429 -1.9981 -0.8383 2070226 Maybridge1_001385 CC(C)c1ccc(cc1)S(=O)(=O)Oc2cccc3ccc(C)nc23 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G22 compound treatment 1564420.0 -256000.0 -1.25 1239300.0 -392000.0 -1.74 1572030.0 -240845.3125 -1.25536244219244 1404700.0 -223342.5 -1.0768705479357 -2.662 -0.9833 2070227 Maybridge1_001386 [O-][N+](=O)c1ccc(nc1)N2CCN(CC2)S(=O)(=O)c3ccc(F)cc3F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G23 mock treatment 1830460.0 10100.0 0.05 1379210.0 -252000.0 -1.12 1871360.0 58484.6875 0.304840809932149 1451770.0 -176272.5 -0.849917340680773 -0.8073 -0.5611 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 G24 mock treatment 1810180.0 -10100.0 -0.05 1655070.0 23500.0 0.1 1763330.0 -49545.3125 -0.258245941569602 1599840.0 -28202.5 -0.13598147073735 -0.1698 -0.541 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H01 compound treatment 1370590.0 -450000.0 -2.2 1646450.0 14900.0 0.07 1607460.0 -205415.3125 -1.07069000300233 1005020.0 -623022.5 -3.00397184123608 -3.1047 -0.8011 2070228 Maybridge1_001387 Cc1cc(C)n(n1)c2ccc(Sc3ccc(Cl)cc3)nn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H02 compound treatment 1497250.0 -323000.0 -1.58 1473250.0 -158000.0 -0.7 1340060.0 -472815.3125 -2.46446393016671 1131800.0 -496242.5 -2.39268805929897 -3.5701 -0.9283 2070229 Maybridge1_001388 CC/1=NN(C(=O)\C1=C/c2cc(Br)cs2)c3cccc(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H03 compound treatment 1220900.0 -599000.0 -2.93 1553150.0 -78400.0 -0.35 1313920.0 -498955.3125 -2.60071393187231 1291740.0 -336302.5 -1.62151967246335 -3.7516 -0.8814 2070230 Maybridge1_001389 Cc1nn(c2ccccc2)c3oc(=O)cc(C)c13 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H04 compound treatment 1346930.0 -473000.0 -2.32 1369760.0 -262000.0 -1.16 1272840.0 -540035.3125 -2.81483596974783 1280410.0 -347632.5 -1.67614851967385 -3.9843 -0.9539 2070231 Maybridge1_001390 [O-][N+](=O)c1ccc(Oc2ccc(cc2)C3SCCS3)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H05 compound treatment 1745080.0 -75200.0 -0.37 1679420.0 47900.0 0.21 1486460.0 -326415.3125 -1.70138052352174 1640530.0 12487.5 0.0602098613893327 -0.8986 -0.5121 2070232 Maybridge1_001391 Cc1n[nH]c2oc(=O)cc(C)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H06 compound treatment 1278880.0 -541000.0 -2.65 1502680.0 -129000.0 -0.57 1300700.0 -512175.3125 -2.66962078047782 1467610.0 -160432.5 -0.773543030017547 -3.3321 -0.8583 2070233 Maybridge1_001392 [O-][N+](=O)c1ccc(Oc2ccc(OCc3ccccc3)cc2)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H07 compound treatment 1462520.0 -358000.0 -1.75 1652190.0 20600.0 0.09 1441220.0 -371655.3125 -1.93718580573908 1590360.0 -37682.5 -0.181690338482765 -1.8891 -0.7213 1033256 Maybridge1_001393 CC1=NN(C(=O)CC1)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H08 compound treatment 990730.0 -830000.0 -4.06 1110920.0 -521000.0 -2.31 1311210.0 -501665.3125 -2.6148393146046 1186480.0 -441562.5 -2.12904239597415 -5.5562 -0.9646 1408705 Maybridge1_001394 O=C(Nc1ccccc1C(=O)NC2CCCCNC2=O)c3cc4ccccc4s3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H09 compound treatment 1247600.0 -573000.0 -2.8 982950.0 -649000.0 -2.88 1399630.0 -413245.3125 -2.15396612597381 1013450.0 -614592.5 -2.96332566453842 -5.3981 -0.9931 2070234 Maybridge1_001395 CC/1=NN(C(=O)\C1=C/c2ccc(Cl)cc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H10 compound treatment 1473480.0 -347000.0 -1.7 1581620.0 -49900.0 -0.22 1644690.0 -168185.3125 -0.876635390779707 1354720.0 -273322.5 -1.31785464180868 -2.0566 -0.8822 2070235 Maybridge1_001396 Cc1nn(nc1c2nnc(o2)c3ccc(Cl)cc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H11 compound treatment 1797150.0 -23200.0 -0.11 1645550.0 14000.0 0.06 1594150.0 -218725.3125 -1.14006596025947 1448000.0 -180042.5 -0.868094812347462 -1.0298 -0.7157 2070236 Maybridge1_001397 CCOC(=O)Cc1csc(N/C=N/O)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H12 compound treatment 95390.0 -1720000.0 -8.44 83910.0 -1550000.0 -6.86 98000.0 -1714875.3125 -8.93847606170669 84560.0 -1543482.5 -7.44207146201087 -15.8424 -0.9948 2070237 Maybridge1_001398 [O-][N+](=O)c1cc2ccccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H13 compound treatment 1595170.0 -225000.0 -1.1 1289040.0 -343000.0 -1.52 1586090.0 -226785.3125 -1.18207724617175 1305610.0 -322432.5 -1.55464393452781 -2.6787 -0.989 2070238 Maybridge1_001399 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)Cc2c(Cl)cccc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H14 compound treatment 1640820.0 -180000.0 -0.88 1532700.0 -98900.0 -0.44 1701400.0 -111475.3125 -0.581044817071808 1334480.0 -293562.5 -1.41544403876725 -1.6566 -0.9113 1441513 Maybridge1_001400 COC(=O)c1ccc(Cl)cc1NS(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H15 compound treatment 1637710.0 -183000.0 -0.89 1401770.0 -230000.0 -1.02 1531330.0 -281545.3125 -1.46750379909442 1655630.0 27587.5 0.133016180266524 -1.6236 -0.811 2070239 Maybridge1_001401 Cc1cc(SCC#N)c(C)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H16 compound treatment 1526670.0 -294000.0 -1.44 1397210.0 -234000.0 -1.04 1532800.0 -280075.3125 -1.45984169111786 1466470.0 -161572.5 -0.779039666012249 -2.3576 -0.972 2070240 Maybridge1_001402 Clc1ccc(cc1)C(=O)Nc2cnccn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H17 compound treatment 1582240.0 -238000.0 -1.17 1366780.0 -265000.0 -1.17 1496640.0 -316235.3125 -1.64831912270449 1138480.0 -489562.5 -2.36047970101423 -3.174 -0.9559 2070241 Maybridge1_001403 Cc1cc(SCC2=NNC(=O)C2)c(C)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H18 compound treatment 1200710.0 -620000.0 -3.03 1219800.0 -412000.0 -1.83 1345680.0 -467195.3125 -2.43517070103184 1276190.0 -351852.5 -1.69649571607529 -4.4949 -0.9731 2070242 Maybridge1_001404 Cc1nn(c2cccc(Cl)c2)c3oc(=O)cc(c13)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H19 compound treatment 1584960.0 -235000.0 -1.15 1493990.0 -138000.0 -0.61 1734400.0 -78475.3125 -0.409038311475606 1564240.0 -63802.5 -0.307630805308741 -1.2392 -0.885 1030549 Maybridge1_001405 O=C1N(CC#N)S(=O)(=O)c2ccccc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H20 compound treatment 1624340.0 -196000.0 -0.96 1529980.0 -102000.0 -0.45 1715360.0 -97515.3125 -0.508280852886263 1579790.0 -48252.5 -0.232654761696799 -1.0752 -0.8975 2070243 Maybridge1_001406 NS(=O)(=O)c1cc(Cl)sc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H21 compound treatment 1710350.0 -110000.0 -0.54 1431240.0 -200000.0 -0.89 1636030.0 -176845.3125 -0.921774067702831 1583890.0 -44152.5 -0.212886158557959 -1.2806 -0.9115 2070244 Maybridge1_001407 CCCC(=O)c1cc2cc(ccc2oc1=O)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H22 compound treatment 1759580.0 -60700.0 -0.3 1502960.0 -129000.0 -0.57 1640230.0 -172645.3125 -0.899882330626951 1560320.0 -67722.5 -0.326531518553681 -1.047 -0.9078 2070245 Maybridge1_001408 COc1cccc(c1)C(=O)NNC(=O)c2ccccc2N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H23 mock treatment 1897060.0 76700.0 0.38 1719200.0 87600.0 0.39 1800740.0 -12135.3125 -0.0632531120437247 1629390.0 1347.5 0.00649712017794802 0.3537 0.65 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 H24 mock treatment 1833870.0 13500.0 0.07 1722050.0 90500.0 0.4 1797310.0 -15565.3125 -0.081131363989027 1685040.0 56997.5 0.274819745708788 0.3306 0.6645 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I01 compound treatment 1506620.0 -314000.0 -1.54 1581360.0 -50200.0 -0.22 1571400.0 -241475.3125 -1.25864620275382 1486250.0 -141792.5 -0.68366820989365 -1.85 -0.8762 2070246 Maybridge1_001409 CS/C(=N/N=C/c1c(F)cccc1Cl)/N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I02 compound treatment 1360710.0 -460000.0 -2.25 1644100.0 12500.0 0.06 1508730.0 -304145.3125 -1.58530219383606 1565170.0 -62872.5 -0.303146707523589 -2.041 -0.7371 2070247 Maybridge1_001410 CC(=O)C(C)(C)OC(=O)N1CCOCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I03 compound treatment 1358080.0 -462000.0 -2.26 1630880.0 -675.0 0.0 1547000.0 -265875.3125 -1.38582677052798 1623680.0 -4362.5 -0.0210342759007779 -1.8359 -0.6921 1019766 Maybridge1_001411 CC(=O)Nc1ccc(C)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I04 compound treatment 1594080.0 -226000.0 -1.11 1638480.0 6920.0 0.03 1560550.0 -252325.3125 -1.31519985686651 1548590.0 -79452.5 -0.38308900997285 -1.3874 -0.7876 1658637 Maybridge1_001412 CC1CN(CC(C)O1)C(=O)CC#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I05 compound treatment 1290940.0 -529000.0 -2.59 1450190.0 -181000.0 -0.8 1417480.0 -395395.3125 -2.06092624340132 1421630.0 -206412.5 -0.995240681803855 -3.2255 -0.9088 2070248 Maybridge1_001413 Cc1cccc(Cl)c1Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I06 compound treatment 884500.0 -936000.0 -4.58 1022890.0 -609000.0 -2.7 1042680.0 -770195.3125 -4.01450316150607 946240.0 -681802.5 -3.28738610769974 -7.2903 -0.9814 1442310 Maybridge1_001414 Clc1ccc(cc1Cl)C(=O)CSC#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I07 compound treatment 937440.0 -883000.0 -4.32 1056960.0 -575000.0 -2.55 1106560.0 -706315.3125 -3.68154026521863 1022600.0 -605442.5 -2.91920792826515 -6.7346 -0.9799 2070249 Maybridge1_001415 COC(=O)c1sc2ccccc2c1OS(=O)(=O)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I08 compound treatment 1236390.0 -584000.0 -2.86 1364580.0 -267000.0 -1.18 1277520.0 -535355.3125 -2.79044231986327 1281600.0 -346442.5 -1.67041080315307 -4.2511 -0.9472 2070250 Maybridge1_001416 Cc1nnc(NC(=O)c2nn(nc2C)c3ccccc3)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I09 compound treatment 1479680.0 -341000.0 -1.67 1524590.0 -107000.0 -0.47 1507780.0 -305095.3125 -1.59025389626989 1630750.0 2707.5 0.0130545104874169 -1.8592 -0.7904 2070251 Maybridge1_001417 Cc1cccc(C)c1Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I10 compound treatment 1543750.0 -277000.0 -1.35 1680000.0 48400.0 0.21 1639630.0 -173245.3125 -0.903009721637791 1592640.0 -35402.5 -0.170697066493362 -1.1061 -0.6704 1165063 Maybridge1_001418 Nc1nc(=O)c2ccccc2[nH]1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I11 compound treatment 1385650.0 -435000.0 -2.13 1419320.0 -212000.0 -0.94 1526530.0 -286345.3125 -1.49252292718114 1416750.0 -211292.5 -1.0187701411496 -2.7898 -0.9471 2070252 Maybridge1_001419 N/C(=N\OC(=O)c1cccs1)/CC(=O)Nc2ccc(F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I12 compound treatment 1645310.0 -175000.0 -0.86 1685240.0 53700.0 0.24 1307620.0 -505255.3125 -2.63355153748613 1531630.0 -96412.5 -0.464863524420344 -1.8584 -0.6594 2070253 Maybridge1_001420 Cc1nnc(N/C=N/O)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I13 compound treatment 1787240.0 -33100.0 -0.16 1664560.0 33000.0 0.15 1642120.0 -170755.3125 -0.890031048942805 1186910.0 -441132.5 -2.12696910344984 -1.5163 -0.6547 2070254 Maybridge1_001421 NC(=O)NCc1cccs1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I14 compound treatment 1652430.0 -168000.0 -0.82 1393920.0 -238000.0 -1.05 1634950.0 -177925.3125 -0.927403371522343 1586290.0 -41752.5 -0.201314293305955 -1.5021 -0.9165 2070255 Maybridge1_001422 Cc1onc(NC(=O)NC(=O)c2c(Cl)cccc2Cl)c1Br 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I15 compound treatment 1022030.0 -798000.0 -3.91 961300.0 -670000.0 -2.97 1171200.0 -641675.3125 -3.34461600698413 1024700.0 -603342.5 -2.90908254616965 -6.5663 -0.9928 2070256 Maybridge1_001423 CC(C)(C)c1ccc(Oc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I16 compound treatment 1130500.0 -690000.0 -3.38 963950.0 -668000.0 -2.96 754600.0 -1058275.3125 -5.5160678321774 735680.0 -892362.5 -4.30262441914222 -8.0775 -0.9717 2070257 Maybridge1_001424 CN(C)/C=N/c1nnc(Sc2ncccc2[N+](=O)[O-])s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I17 compound treatment 1643840.0 -176000.0 -0.86 1258590.0 -373000.0 -1.65 1669710.0 -143165.3125 -0.746223185627677 1523440.0 -104602.5 -0.504352514592807 -1.8841 -0.9094 2070258 Maybridge1_001425 OCCNc1ccc(cc1[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I18 compound treatment 1744700.0 -75600.0 -0.37 1748480.0 117000.0 0.52 1711370.0 -101505.3125 -0.52907800310835 1501520.0 -126522.5 -0.610042217227776 -0.4953 -0.4816 1236124 Maybridge1_001426 S=C1NCN(CC2CC2)CN1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I19 compound treatment 1691250.0 -129000.0 -0.63 1617190.0 -14400.0 -0.06 1705450.0 -107425.3125 -0.559934927748638 1636090.0 8047.5 0.0388019106731255 -0.6082 -0.7178 1158168 Maybridge1_001427 COC(=O)c1cc(OC)c(OC)c(OC)c1NC(=O)c2cccs2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I20 compound treatment 1666490.0 -154000.0 -0.75 1428270.0 -203000.0 -0.9 1654820.0 -158055.3125 -0.823834605880024 1420800.0 -207242.5 -0.99924261853684 -1.7387 -0.9945 1229472 Maybridge1_001428 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)Nc2ccccc2C(=O)NCC3CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I21 compound treatment 1585520.0 -235000.0 -1.15 1471720.0 -160000.0 -0.71 1534620.0 -278255.3125 -1.45035527171831 1485280.0 -142762.5 -0.688345172099669 -1.9983 -0.9526 1694034 Maybridge1_001429 CN1C(NC(=O)c2ccccc12)c3cc(Br)cs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I22 compound treatment 1680720.0 -140000.0 -0.68 1471430.0 -160000.0 -0.71 1655210.0 -157665.3125 -0.821801801722978 1434180.0 -193862.5 -0.934729469756918 -1.5749 -0.9921 2070259 Maybridge1_001430 [O-][N+](=O)c1ccc(nc1)N2CCN(CC2)S(=O)(=O)c3ccc(F)c(Cl)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I23 mock treatment 1747300.0 -73000.0 -0.36 1427900.0 -204000.0 -0.9 1773550.0 -39325.3125 -0.204976048018293 1530730.0 -97312.5 -0.469202973889845 -0.9673 -0.881 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 I24 mock treatment 1836700.0 16400.0 0.08 1695440.0 63900.0 0.28 1832240.0 19364.6875 0.100934916025378 1727280.0 99237.5 0.478484574144057 0.4714 0.8259 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J01 compound treatment 1282280.0 -538000.0 -2.63 1412450.0 -219000.0 -0.97 1283420.0 -529455.3125 -2.75968964159001 915840.0 -712202.5 -3.43396306755846 -4.8991 -0.9379 2070260 Maybridge1_001431 Nc1ccc(Cl)cc1C(=O)N2CCN(CC2)c3ccc(cn3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J02 compound treatment 1673690.0 -147000.0 -0.72 1661990.0 30400.0 0.13 1350260.0 -462615.3125 -2.41129828298243 1220170.0 -407872.5 -1.96660233749915 -2.4802 -0.776 2070261 Maybridge1_001432 Oc1cc(Sc2ccccc2)ccc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J03 compound treatment 1302630.0 -518000.0 -2.53 1350080.0 -281000.0 -1.25 1706770.0 -106105.3125 -0.55305466752479 1490240.0 -137802.5 -0.664429983912194 -2.4995 -0.8463 2070262 Maybridge1_001433 Cc1nn(C)c2oc(=O)cc(c12)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J04 compound treatment 1666020.0 -154000.0 -0.76 1645060.0 13500.0 0.06 1626560.0 -186315.3125 -0.97113472249059 1423290.0 -204752.5 -0.987236808337886 -1.3268 -0.8406 1021654 Maybridge1_001434 CC(=O)Nc1ccc(cc1C)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J05 compound treatment 1295920.0 -524000.0 -2.57 1526880.0 -105000.0 -0.46 1405640.0 -407235.3125 -2.12264009268189 1388260.0 -239782.5 -1.15613782491193 -3.1546 -0.8872 2070263 Maybridge1_001435 CC1CCN(CC1)c2ccc([N+](=O)[O-])c(Oc3nc4c(Cl)cc(Cl)cc4s3)c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J06 compound treatment 1569620.0 -251000.0 -1.23 1455930.0 -176000.0 -0.78 1705680.0 -107195.3125 -0.558736094527816 1495240.0 -132802.5 -0.640321931303853 -1.6024 -0.9519 2070264 Maybridge1_001436 [O-][N+](=O)c1ccc(Oc2ccc(OCc3ccccc3)cc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J07 compound treatment 1451610.0 -369000.0 -1.8 1502600.0 -129000.0 -0.57 1607150.0 -205725.3125 -1.07230582169127 1536540.0 -91502.5 -0.441189416758952 -1.9448 -0.8762 2070265 Maybridge1_001437 Clc1ccc(I)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J08 compound treatment 1629880.0 -190000.0 -0.93 1580960.0 -50600.0 -0.22 1495150.0 -317725.3125 -1.65608547704807 1569170.0 -58872.5 -0.283860265436916 -1.5481 -0.8003 1424245 Maybridge1_001438 Clc1ccc(cc1)C(=O)Nc2ccccc2C(=O)NC3CCCCNC3=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J09 compound treatment 1450270.0 -370000.0 -1.81 1414560.0 -217000.0 -0.96 1405570.0 -407305.3125 -2.12300495496649 1484100.0 -143942.5 -0.694034672515237 -2.7951 -0.9218 2070266 Maybridge1_001439 Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J10 compound treatment 1635910.0 -184000.0 -0.9 1414910.0 -217000.0 -0.96 1656730.0 -156145.3125 -0.81387907782885 1437230.0 -190812.5 -0.92002355766583 -1.7986 -0.9982 2070267 Maybridge1_001440 Cc1nn(nc1c2nnc(o2)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J11 compound treatment 1420230.0 -400000.0 -1.96 1528480.0 -103000.0 -0.46 1590880.0 -221995.3125 -1.15711024126854 1388240.0 -239802.5 -1.15623425712236 -2.3642 -0.9121 2070268 Maybridge1_001441 Cc1ccc2cc(ccc2n1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J12 compound treatment 1577640.0 -243000.0 -1.19 1677960.0 46400.0 0.21 1693980.0 -118895.3125 -0.619720219239197 1470780.0 -157262.5 -0.758258524663859 -1.1799 -0.7598 2070269 Maybridge1_001442 Clc1ccc(NC(=O)CC#N)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J13 compound treatment 1894210.0 73900.0 0.36 1624960.0 -6600.0 -0.03 1695360.0 -117515.3125 -0.612527219914265 1551000.0 -77042.5 -0.371468928615629 -0.3259 -0.4058 1013980 Maybridge1_001443 OS(=O)(=O)c1cccc2cccc(Cl)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J14 compound treatment 1777320.0 -43000.0 -0.21 1573300.0 -58300.0 -0.26 1782290.0 -30585.3125 -0.159420385627056 1597600.0 -30442.5 -0.146781878305887 -0.3875 -0.9749 2070270 Maybridge1_001444 O=C(CC#N)Nc1ccccn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J15 compound treatment 1863460.0 43100.0 0.21 1592640.0 -38900.0 -0.17 1339720.0 -473155.3125 -2.46623611840619 1489240.0 -138802.5 -0.669251594433862 -1.5485 -0.6025 2070271 Maybridge1_001445 CSc1ncccc1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J16 compound treatment 1428020.0 -392000.0 -1.92 1306670.0 -325000.0 -1.44 1286650.0 -526225.3125 -2.74285385331499 1359220.0 -268822.5 -1.29615739446117 -3.6998 -0.9564 1160934 Maybridge1_001446 Clc1ccc(NC(=O)c2cnccn2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J17 compound treatment 1783590.0 -36700.0 -0.18 1420250.0 -211000.0 -0.94 1596850.0 -216025.3125 -1.12599270071069 1608520.0 -19522.5 -0.0941298914092691 -1.1685 -0.7901 2070272 Maybridge1_001447 O=C1CC(=NN1)CSc2ccccn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J18 compound treatment 1746930.0 -73400.0 -0.36 1565070.0 -66500.0 -0.29 1686980.0 -125895.3125 -0.656206447698997 1718530.0 90487.5 0.436295482079459 -0.437 -0.4776 2070273 Maybridge1_001448 Cc1nn(c2ccccc2)c3oc(=O)cc(c13)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J19 compound treatment 1712720.0 -108000.0 -0.53 1535540.0 -96000.0 -0.43 1663720.0 -149155.3125 -0.777444972552563 1635320.0 7277.5 0.0350892705714409 -0.8474 -0.8214 1234815 Maybridge1_001449 CCSc1ncccc1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J20 compound treatment 1734190.0 -86100.0 -0.42 1416160.0 -215000.0 -0.96 1676500.0 -136375.3125 -0.71083154402167 1245920.0 -382122.5 -1.84244586656619 -1.965 -0.8797 1422595 Maybridge1_001450 Fc1cccc(Cl)c1CN2c3ccccc3C(=O)CS2(=O)=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J21 compound treatment 1813620.0 -6710.0 -0.03 1305340.0 -326000.0 -1.45 1778830.0 -34045.3125 -0.1774550071229 1470560.0 -157482.5 -0.759319278978626 -1.2081 -0.735 1531298 Maybridge1_001451 CCCC(=O)c1cc2cc(Br)cc(Br)c2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J22 compound treatment 1611300.0 -209000.0 -1.02 1606010.0 -25500.0 -0.11 1608800.0 -204075.3125 -1.06370549641146 1417540.0 -210502.5 -1.01496106883748 -1.6074 -0.8957 1487398 Maybridge1_001452 Fc1ccc(cc1F)C(=O)c2cc3ccccc3o2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J23 mock treatment 1882170.0 61800.0 0.3 1780090.0 149000.0 0.66 1815560.0 2684.6875 0.0139934459240244 1627440.0 -602.5 -0.00290502033930514 0.4862 0.6706 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 J24 mock treatment 1828860.0 8530.0 0.04 1546490.0 -85100.0 -0.38 1777730.0 -35145.3125 -0.183188557309441 1685410.0 57367.5 0.276603741601805 -0.121 -0.2401 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K01 compound treatment 1516000.0 -304000.0 -1.49 1482790.0 -149000.0 -0.66 1557760.0 -255115.3125 -1.32974222506692 1496840.0 -131202.5 -0.632607354469183 -2.0556 -0.9362 2070274 Maybridge1_001453 CS/C(=N/N=C/c1ccc(cc1)N(C)C)/N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K02 compound treatment 1434720.0 -386000.0 -1.89 1600850.0 -30700.0 -0.14 1621460.0 -191415.3125 -0.99771754608273 1565970.0 -62072.5 -0.299289419106255 -1.6601 -0.7687 2070275 Maybridge1_001454 Clc1ccc2[nH]c(nc(=O)c2c1)c3cc(Br)cs3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K03 compound treatment 1555280.0 -265000.0 -1.3 1614400.0 -17200.0 -0.08 1506560.0 -306315.3125 -1.5966129246586 1204490.0 -423552.5 -2.04220519047891 -2.5059 -0.8642 1143063 Maybridge1_001455 COc1ccc(Oc2cc(C)nc3ccccc23)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K04 compound treatment 1415930.0 -404000.0 -1.98 1607750.0 -23800.0 -0.11 1530620.0 -282255.3125 -1.47120454512391 1536440.0 -91602.5 -0.441671577811119 -1.9987 -0.7971 2070276 Maybridge1_001456 O=C(CC#N)N1CCSCC1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K05 compound treatment 1618820.0 -202000.0 -0.99 1770580.0 139000.0 0.62 1589720.0 -223155.3125 -1.16315653055617 1621550.0 -6492.5 -0.0313043063119313 -0.782 -0.4753 1037135 Maybridge1_001457 Cc1cc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)ccc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K06 compound treatment 1073600.0 -747000.0 -3.65 1164390.0 -467000.0 -2.07 1032480.0 -780395.3125 -4.06766880869035 1062750.0 -565292.5 -2.72562026582017 -6.2595 -0.9703 2070277 Maybridge1_001458 Cc1onc(NC(=O)c2ccc(o2)[N+](=O)[O-])c1Br 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K07 compound treatment 785040.0 -1040000.0 -5.07 858120.0 -773000.0 -3.43 780170.0 -1032705.3125 -5.3827888519321 843630.0 -784412.5 -3.78213156332812 -8.8305 -0.9829 2070278 Maybridge1_001459 COC(=O)c1sc2ccccc2c1OS(=O)(=O)c3ccc(OC)c(OC)c3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K08 compound treatment 1404360.0 -416000.0 -2.04 1543080.0 -88500.0 -0.39 1480160.0 -332715.3125 -1.73421812913556 1551520.0 -76522.5 -0.368961691144361 -2.2655 -0.8305 1403130 Maybridge1_001460 CCc1nnc(NC(=O)c2nn(nc2C)c3ccccc3)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K09 compound treatment 810360.0 -1010000.0 -4.94 985310.0 -646000.0 -2.87 963390.0 -849485.3125 -4.42778788358858 1106720.0 -521322.5 -2.51361405118242 -7.3748 -0.9637 2070279 Maybridge1_001461 CSc1ccc(Oc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K10 compound treatment 1609620.0 -211000.0 -1.03 1579400.0 -52200.0 -0.23 1717250.0 -95625.3125 -0.498429571202117 1647410.0 19367.5 0.0933825417784105 -0.8337 -0.7113 2070280 Maybridge1_001462 CC(=O)c1cc2cc(Br)ccc2o1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K11 compound treatment 1516760.0 -304000.0 -1.49 1461290.0 -170000.0 -0.76 1446260.0 -366615.3125 -1.91091572124802 1340380.0 -287662.5 -1.3869965366894 -2.7692 -0.9582 2070281 Maybridge1_001463 COc1ccc(OC)c2nc3-c4ccccc4C(=O)c3nc12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K12 compound treatment 1772240.0 -48100.0 -0.24 1611890.0 -19700.0 -0.09 1676010.0 -136865.3125 -0.713385580013856 1610580.0 -17462.5 -0.0841973737346324 -0.5601 -0.736 1537115 Maybridge1_001464 Fc1ccc(NC(=O)Cc2nn[nH]n2)c(F)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K13 compound treatment 1452210.0 -368000.0 -1.8 1370050.0 -262000.0 -1.16 1301820.0 -511055.3125 -2.66378298392425 1358980.0 -269062.5 -1.29731458098637 -3.4611 -0.9466 2070282 Maybridge1_001465 CC(=O)C1=CN=C(SC1)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K14 compound treatment 1776800.0 -43500.0 -0.21 1697550.0 66000.0 0.29 1678760.0 -134115.3125 -0.699051704547506 1574020.0 -54022.5 -0.260475454406825 -0.4399 -0.5306 2070283 Maybridge1_001466 COC(=O)CS(=O)(=O)c1cc(C)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K15 compound treatment 1645920.0 -174000.0 -0.85 1392480.0 -239000.0 -1.06 1747330.0 -65545.3125 -0.341643035192003 1544230.0 -83812.5 -0.404111231847323 -1.3297 -0.9106 1046920 Maybridge1_001467 COC(=O)c1cc(OC)c(OC)c(OC)c1N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K16 compound treatment 1586670.0 -234000.0 -1.14 1361980.0 -270000.0 -1.2 1430010.0 -382865.3125 -1.99561589445827 1453440.0 -174602.5 -0.841865251109587 -2.5882 -0.9497 2070284 Maybridge1_001468 CCc1ccc(cc1)c2ccc(OC(=O)c3c(Br)cc(cc3[N+](=O)[O-])C(F)(F)F)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K17 compound treatment 1558460.0 -262000.0 -1.28 1279050.0 -353000.0 -1.56 1412760.0 -400115.3125 -2.08552838601993 1321940.0 -306102.5 -1.47590703470897 -3.2031 -0.9832 2070285 Maybridge1_001469 CC(C)(CO)Nc1ccc(cc1[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K18 compound treatment 1809400.0 -10900.0 -0.05 1626360.0 -5200.0 -0.02 1607680.0 -205195.3125 -1.06954329296502 1599750.0 -28292.5 -0.1364154156843 -0.6412 -0.5939 1162688 Maybridge1_001470 Fc1ccc(cc1Cl)S(=O)(=O)NCC2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K19 compound treatment 1764280.0 -56000.0 -0.27 1485710.0 -146000.0 -0.65 1655520.0 -157355.3125 -0.820185983034044 1259890.0 -368152.5 -1.77508796757848 -1.7582 -0.8462 2070286 Maybridge1_001471 OC(=O)CSc1ccccn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K20 compound treatment 1660760.0 -160000.0 -0.78 1504990.0 -127000.0 -0.56 1748960.0 -63915.3125 -0.333146956279221 1606920.0 -21122.5 -0.101844468243938 -0.8886 -0.8688 2070287 Maybridge1_001472 COc1ccc([N+](=O)[O-])c(OC)c1C(=O)Nc2ccccc2C(=O)NCC3CC3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K21 compound treatment 1198090.0 -622000.0 -3.04 1111680.0 -520000.0 -2.31 1123390.0 -689485.3125 -3.59381694736457 1156970.0 -471072.5 -2.27132812246858 -5.6078 -0.9812 1227697 Maybridge1_001473 Brc1csc(c1)C2NC(=O)c3ccccc3N2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K22 compound treatment 1765390.0 -54900.0 -0.27 1551010.0 -80500.0 -0.36 1614720.0 -198155.3125 -1.03284857177117 1589520.0 -38522.5 -0.185740491320967 -0.9223 -0.8086 2070288 Maybridge1_001474 [O-][N+](=O)c1ccc(nc1)N2CCN(CC2)S(=O)(=O)c3ccc(Cl)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K23 mock treatment 1858400.0 38100.0 0.19 1504420.0 -127000.0 -0.56 1858240.0 45364.6875 0.23645519316178 1542640.0 -85402.5 -0.411777592576776 -0.2764 -0.3636 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 K24 mock treatment 1916490.0 96200.0 0.47 1680960.0 49400.0 0.22 1849010.0 36134.6875 0.188345494778357 1743200.0 115157.5 0.555244613649016 0.7166 0.9151 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L01 compound treatment 1324480.0 -496000.0 -2.43 1612640.0 -18900.0 -0.08 1595400.0 -217475.3125 -1.13355056232022 1112430.0 -515612.5 -2.48608265510369 -3.065 -0.8385 2070289 Maybridge1_001475 Nc1ccccc1C(=O)N2CCN(CC2)c3ccc(cn3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L02 compound treatment 1660840.0 -159000.0 -0.78 1613120.0 -18400.0 -0.08 1356900.0 -455975.3125 -2.37668848912913 1411960.0 -216082.5 -1.04186565554839 -2.1404 -0.7895 2070290 Maybridge1_001476 Cc1cc(Sc2ccc([N+](=O)[O-])c(O)c2)c(C)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L03 compound treatment 1675040.0 -145000.0 -0.71 1656330.0 24800.0 0.11 1359410.0 -453465.3125 -2.36360557006712 1453450.0 -174592.5 -0.84181703500437 -1.9033 -0.7292 1174018 Maybridge1_001477 Cc1nc2ccc(Cl)cc2c(O)c1I 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L04 compound treatment 1522570.0 -298000.0 -1.46 1705760.0 74200.0 0.33 1592800.0 -220075.3125 -1.14710259003386 1599090.0 -28952.5 -0.139597678628601 -1.2073 -0.6393 2070291 Maybridge1_001478 N#Cc1cccnc1Sc2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L05 compound treatment 1635520.0 -185000.0 -0.9 1731850.0 100000.0 0.44 1508490.0 -304385.3125 -1.5865531502404 1511150.0 -116892.5 -0.56361010790411 -1.3049 -0.665 2070292 Maybridge1_001479 Cc1cc(C)n(n1)c2ccc(Sc3ccccn3)nn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L06 compound treatment 1445440.0 -375000.0 -1.83 1494500.0 -137000.0 -0.61 1364380.0 -448495.3125 -2.33770034786066 1516640.0 -111402.5 -0.537139466140151 -2.6586 -0.8631 2070293 Maybridge1_001480 COc1cc(cc(Br)c1OS(=O)(=O)c2ccc(C)cc2)C3SCCS3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L07 compound treatment 1370950.0 -449000.0 -2.2 1484750.0 -147000.0 -0.65 1349520.0 -463355.3125 -2.41515539856247 1363690.0 -264352.5 -1.27460479542932 -3.2699 -0.9169 2070294 Maybridge1_001481 CN(C)/C=C/1\C(=NN(C1=O)c2ccccc2)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L08 compound treatment 1717030.0 -103000.0 -0.51 1698770.0 67200.0 0.3 1575650.0 -237225.3125 -1.23649384976037 1573760.0 -54282.5 -0.261729073142459 -0.8528 -0.612 2070295 Maybridge1_001482 COc1cc(Sc2ccc(Cl)cc2)ccc1[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L09 compound treatment 1591750.0 -229000.0 -1.12 1608540.0 -23000.0 -0.1 1472070.0 -340805.3125 -1.77638578459839 1504490.0 -123552.5 -0.595722033978421 -1.7964 -0.8223 2070296 Maybridge1_001483 Fc1cccc(NC(=O)c2cccc(Cl)c2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L10 compound treatment 1660420.0 -160000.0 -0.78 1590090.0 -41500.0 -0.18 1640190.0 -172685.3125 -0.900090823361007 1553640.0 -74402.5 -0.358739876838425 -1.1126 -0.8838 1412717 Maybridge1_001484 Fc1ccccc1NC(=O)CC#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L11 compound treatment 1636830.0 -183000.0 -0.9 1560400.0 -71200.0 -0.32 1520220.0 -292655.3125 -1.52541265597847 1414560.0 -213482.5 -1.02932946819205 -1.8841 -0.9094 2070297 Maybridge1_001485 Cc1cc(Sc2ncccc2[N+](=O)[O-])c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L12 compound treatment 472170.0 -1350000.0 -6.6 898110.0 -733000.0 -3.25 891960.0 -920915.3125 -4.80010378342909 394350.0 -1233692.5 -5.94838473850325 -10.2991 -0.9709 2070298 Maybridge1_001486 [O-][N+](=O)c1ccc(Oc2cc(ccc2[N+](=O)[O-])S(=O)(=O)c3ccccc3)nc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L13 compound treatment 81390.0 -1740000.0 -8.51 75570.0 -1560000.0 -6.9 76640.0 -1736235.3125 -9.0498111816926 75170.0 -1552872.5 -7.48734638480934 -15.9734 -0.9945 2070299 Maybridge1_001487 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)c2ccc(cc2[N+](=O)[O-])C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L14 compound treatment 1645760.0 -175000.0 -0.85 1597460.0 -34100.0 -0.15 1693390.0 -119485.3125 -0.622795487066523 1578650.0 -49392.5 -0.238151397691501 -0.9332 -0.8529 1076266 Maybridge1_001488 Clc1ccc(NC(=O)c2cccnc2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L15 compound treatment 1836640.0 16300.0 0.08 1682800.0 51200.0 0.23 1840530.0 27654.6875 0.144145035158484 1666720.0 38677.5 0.186487840951825 0.3189 0.9461 2070300 Maybridge1_001489 Cc1cc(c(C)cc1Cl)S(=O)(=O)CC#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L16 compound treatment 1709780.0 -111000.0 -0.54 1461620.0 -170000.0 -0.75 1667370.0 -145505.3125 -0.758420010569953 1604160.0 -23882.5 -0.115152113283743 -1.0841 -0.9006 2070301 Maybridge1_001490 Cc1ccc(Sc2ccc(cc2[N+](=O)[O-])C(=O)O)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L17 compound treatment 1579680.0 -241000.0 -1.18 1463840.0 -168000.0 -0.74 1462370.0 -350505.3125 -1.82694527260697 1488040.0 -140002.5 -0.675037527059864 -2.2117 -0.9237 2070302 Maybridge1_001491 Clc1ccc(SCC2=NNC(=O)C2)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L18 compound treatment 1698180.0 -122000.0 -0.6 1612000.0 -19600.0 -0.09 1624810.0 -188065.3125 -0.98025627960554 1558760.0 -69282.5 -0.334053230967483 -0.9994 -0.8336 1046560 Maybridge1_001492 COc1ccc(NC(=S)N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L19 compound treatment 1845530.0 25200.0 0.12 1755880.0 124000.0 0.55 1763520.0 -49355.3125 -0.257255601082836 1633530.0 5487.5 0.0264585877376547 0.2219 0.3572 2070303 Maybridge1_001493 CC(=O)CN1C(=O)c2ccccc2S1(=O)=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L20 compound treatment 1688800.0 -132000.0 -0.64 1424050.0 -208000.0 -0.92 1690020.0 -122855.3125 -0.640360999910741 1541920.0 -86122.5 -0.415249152152377 -1.3097 -0.9646 1450792 Maybridge1_001494 COC(=O)c1ccc(Cl)cc1N(Cc2ccccc2)S(=O)(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L21 compound treatment 1702810.0 -118000.0 -0.58 1715890.0 84300.0 0.37 1635420.0 -177455.3125 -0.924953581897185 1639220.0 11177.5 0.0538935516059473 -0.5361 -0.465 1377255 Maybridge1_001495 CCCC(=O)c1cc2cc(Br)ccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L22 compound treatment 1665600.0 -155000.0 -0.76 1533760.0 -97800.0 -0.43 1650950.0 -161925.3125 -0.844006277899942 1564440.0 -63602.5 -0.306666483204407 -1.1708 -0.935 1230653 Maybridge1_001496 Clc1ccc2C(=O)CS(=O)(=O)N(Cc3ccccc3)c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L23 mock treatment 1824800.0 4470.0 0.02 1502990.0 -129000.0 -0.57 1870880.0 58004.6875 0.302338897123477 1428500.0 -199542.5 -0.962116217519994 -0.604 -0.5213 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 L24 mock treatment 1852320.0 32000.0 0.16 1747960.0 116000.0 0.52 1795420.0 -17455.3125 -0.0909826456731731 1816180.0 188137.5 0.907125749520367 0.7445 0.7028 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M01 compound treatment 1668320.0 -152000.0 -0.74 1649600.0 18000.0 0.08 1755580.0 -57295.3125 -0.298641408792952 1630660.0 2617.5 0.0126205655404667 -0.4749 -0.5895 2070304 Maybridge1_001497 CSC1=NC=C(C#N)C2=NC(NN21)c3ccc(cc3)N(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M02 compound treatment 1750290.0 -70000.0 -0.34 1726500.0 94900.0 0.42 1320420.0 -492455.3125 -2.56683386258821 1601760.0 -26282.5 -0.126723978535747 -1.3076 -0.4978 2070305 Maybridge1_001498 CC(=O)C(C)(C)OC(=O)NCCc1ccccn1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M03 compound treatment 1530780.0 -290000.0 -1.42 1459680.0 -172000.0 -0.76 1634100.0 -178775.3125 -0.931833842121033 1662150.0 34107.5 0.164453080867801 -1.4732 -0.7893 2070306 Maybridge1_001499 [O-][N+](=O)c1cccc(Cl)c1Oc2ccc(cc2)c3ccc(Oc4c(Cl)cccc4[N+](=O)[O-])cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M04 compound treatment 1641150.0 -179000.0 -0.88 1651680.0 20100.0 0.09 1391920.0 -420955.3125 -2.1941531004631 1528610.0 -99432.5 -0.479424788195782 -1.7306 -0.7173 2070307 Maybridge1_001500 COC(=O)c1cc(OC)c(OC)c(OC)c1NS(=O)(=O)c2cc(OC)ccc2OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M05 compound treatment 1692320.0 -128000.0 -0.63 1752000.0 120000.0 0.53 1607210.0 -205665.3125 -1.07199308259018 1694260.0 66217.5 0.31927499471857 -0.4225 -0.3042 2070308 Maybridge1_001501 COc1ccc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M06 compound treatment 1665490.0 -155000.0 -0.76 1637570.0 6010.0 0.03 1672720.0 -140155.3125 -0.730534107389962 1595540.0 -32502.5 -0.156714395980523 -0.8091 -0.7601 2070309 Maybridge1_001502 COc1ccccc1NC(=O)/C=N/O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M07 compound treatment 1798590.0 -21700.0 -0.11 1759150.0 128000.0 0.57 1474140.0 -338735.3125 -1.76559628561099 1705960.0 77917.5 0.375687837822089 -0.4652 -0.2455 2070310 Maybridge1_001503 [O-][N+](=O)c1cc(ccc1Oc2ccc(F)cc2F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M08 compound treatment 1455840.0 -364000.0 -1.78 1467840.0 -164000.0 -0.73 1336840.0 -476035.3125 -2.48124759525822 1399290.0 -228752.5 -1.10295546085792 -3.0469 -0.9153 2070311 Maybridge1_001504 CSC1=NCCN1C(=O)c2nn(nc2C)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M09 compound treatment 1814890.0 -5440.0 -0.03 1893660.0 262000.0 1.16 1467450.0 -345425.3125 -1.80046669538186 1765870.0 137827.5 0.664550524175236 -1.0E-4 0.0 2070312 Maybridge1_001505 [O-][N+](=O)c1cc(ccc1Oc2ccc(cc2)c3ccccc3)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M10 compound treatment 1564370.0 -256000.0 -1.25 1506940.0 -125000.0 -0.55 1583850.0 -229025.3125 -1.19375283927889 1559050.0 -68992.5 -0.332654963916199 -1.6658 -0.9021 2070313 Maybridge1_001506 CN(C)/C=C(\C#N)/C(=O)Nc1ccc(C)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M11 compound treatment 1007960.0 -812000.0 -3.98 903420.0 -728000.0 -3.23 1011160.0 -801715.3125 -4.1787954359422 1068510.0 -559532.5 -2.69784778921536 -7.0405 -0.9862 1452789 Maybridge1_001507 Cc1ccc2nc3C(=O)c4ccccc4-c3nc2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M12 compound treatment 1795600.0 -24700.0 -0.12 1761550.0 130000.0 0.58 1662560.0 -150315.3125 -0.783491261840187 1642460.0 14417.5 0.0695155696961525 -0.1292 -0.1315 1172166 Maybridge1_001508 Clc1cc(Cl)cc(NC(=O)Cc2nn[nH]n2)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M13 compound treatment 1808960.0 -11400.0 -0.06 1667100.0 35500.0 0.16 1725550.0 -87325.3125 -0.455167328885496 1593880.0 -34162.5 -0.164718269446493 -0.2589 -0.5056 2070314 Maybridge1_001509 Nc1ccccc1C(=O)NNc2c(Cl)cc(Cl)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M14 compound treatment 1783130.0 -37200.0 -0.18 1785500.0 154000.0 0.68 1709880.0 -102995.3125 -0.536844357451936 1622720.0 -5322.5 -0.0256630220015795 -0.0309 -0.0348 2070315 Maybridge1_001510 COC(=O)CS(=O)(=O)c1cc(C)c(Cl)cc1C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M15 compound treatment 1629600.0 -191000.0 -0.93 1440130.0 -191000.0 -0.85 1594130.0 -218745.3125 -1.14017020662649 1562560.0 -65482.5 -0.315731110985144 -1.6191 -0.9361 2070316 Maybridge1_001511 Cc1onc(c1C(=O)Nc2ccccc2C(=O)NNc3c(Cl)cc(Cl)cc3Cl)c4c(Cl)cccc4Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M16 compound treatment 1614160.0 -206000.0 -1.01 1649790.0 18200.0 0.08 1554940.0 -257935.3125 -1.34444096281786 1493150.0 -134892.5 -0.650399097294139 -1.4614 -0.81 1284149 Maybridge1_001512 O=C(NCC1CC1)c2cccnc2Oc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M17 compound treatment 1833660.0 13300.0 0.07 1711370.0 79800.0 0.35 1771380.0 -41495.3125 -0.216286778840831 1491130.0 -136912.5 -0.660138750547909 -0.2286 -0.2922 1482069 Maybridge1_001513 COc1cc(C(=O)O)c(NC(=O)C)c(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M18 compound treatment 1691060.0 -129000.0 -0.63 1423450.0 -208000.0 -0.92 1295490.0 -517385.3125 -2.69677695908861 1488350.0 -139692.5 -0.673542827798147 -2.4629 -0.822 1148165 Maybridge1_001514 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)NCC2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M19 compound treatment 1709820.0 -111000.0 -0.54 1534350.0 -97200.0 -0.43 1693820.0 -119055.3125 -0.620554190175421 1521220.0 -106822.5 -0.51505648995091 -1.0537 -0.9919 2070317 Maybridge1_001515 COc1ccc(cc1)/C(=C/c2cc(Br)cs2)/C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M20 compound treatment 1799880.0 -20400.0 -0.1 1582880.0 -48700.0 -0.22 1746940.0 -65935.3125 -0.343675839349049 1562350.0 -65692.5 -0.316743649194694 -0.4882 -0.9308 2070318 Maybridge1_001516 CN(C)/C=N/S(=O)(=O)c1cc(C)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M21 compound treatment 1732920.0 -87400.0 -0.43 1526290.0 -105000.0 -0.47 1693600.0 -119275.3125 -0.621700900212729 1607940.0 -20102.5 -0.0969264255118367 -0.8066 -0.9036 2070319 Maybridge1_001517 CCCCCC(=O)c1cc(C)c(C)cc1NC(=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M22 compound treatment 1743640.0 -76700.0 -0.38 1709890.0 78300.0 0.35 1654320.0 -158555.3125 -0.826440765055724 1664370.0 36327.5 0.175157056225905 -0.3396 -0.3439 2070320 Maybridge1_001518 Cc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccc(cn3)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M23 mock treatment 1958000.0 138000.0 0.67 1581880.0 -49700.0 -0.22 1826720.0 13844.6875 0.0721629187256492 1562930.0 -65112.5 -0.313947115092126 0.1058 0.1359 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 M24 mock treatment 1892090.0 71800.0 0.35 1847150.0 216000.0 0.96 1792270.0 -20605.3125 -0.107401448480083 1779570.0 151527.5 0.730606588322091 0.9652 0.7672 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N01 compound treatment 1643690.0 -177000.0 -0.86 1705710.0 74200.0 0.33 1732320.0 -80555.3125 -0.419879933646518 1117240.0 -510802.5 -2.46289070849446 -1.7091 -0.6415 2070321 Maybridge1_001519 Fc1cccc(Cl)c1CN(NC(=O)NC(=O)c2c(F)cccc2Cl)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N02 compound treatment 1808230.0 -12100.0 -0.06 1735460.0 104000.0 0.46 1672340.0 -140535.3125 -0.732514788363494 1385200.0 -242842.5 -1.17089195310823 -0.7509 -0.5153 2070322 Maybridge1_001520 Oc1cc(ccc1[N+](=O)[O-])S(=O)(=O)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N03 compound treatment 1661730.0 -159000.0 -0.78 1642880.0 11300.0 0.05 1404610.0 -408265.3125 -2.12800878058384 1475840.0 -152202.5 -0.733861175424217 -1.7939 -0.7532 2070323 Maybridge1_001521 Nc1nnc(Sc2ccc(cc2[N+](=O)[O-])C(F)(F)F)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N04 compound treatment 1662280.0 -158000.0 -0.77 1688000.0 56400.0 0.25 1532730.0 -280145.3125 -1.46020655340246 1330610.0 -297432.5 -1.4341036714861 -1.7087 -0.7759 2070324 Maybridge1_001522 Clc1ccc(cc1Cl)C(=O)CN2CCSC2=N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N05 compound treatment 1779910.0 -40400.0 -0.2 1741290.0 110000.0 0.49 1476770.0 -336105.3125 -1.75188788834681 1655720.0 27677.5 0.133450125213474 -0.6648 -0.3625 2070325 Maybridge1_001523 N/C(=N\O)/CS(=O)(=O)c1ccc(Cl)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N06 compound treatment 1717860.0 -102000.0 -0.5 1628090.0 -3470.0 -0.02 1527240.0 -285635.3125 -1.48882218115165 1639390.0 11347.5 0.0547132253946309 -0.9754 -0.6205 2070326 Maybridge1_001524 CCc1nn2cc(nc2s1)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N07 compound treatment 1755200.0 -65100.0 -0.32 1785140.0 154000.0 0.68 1682200.0 -130675.3125 -0.68112132941869 1693760.0 65717.5 0.316864189457736 -9.0E-4 -9.0E-4 2070327 Maybridge1_001525 CC/1=NN(C(=O)\C1=C\c2c(C)nn(c2O)c3ccccc3)c4ccccc4 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N08 compound treatment 1499760.0 -321000.0 -1.57 1700560.0 69000.0 0.31 1435360.0 -377515.3125 -1.96772999127828 1556030.0 -72012.5 -0.347216227691637 -1.7888 -0.6991 2070328 Maybridge1_001526 [O-][N+](=O)c1ccc(Sc2ccccc2)cc1OCC#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N09 compound treatment 1641980.0 -178000.0 -0.87 1645280.0 13700.0 0.06 1376980.0 -435895.3125 -2.27202513663302 1592360.0 -35682.5 -0.172047117439429 -1.628 -0.667 1037692 Maybridge1_001527 O=C1CC(=NN1c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N10 compound treatment 1662200.0 -158000.0 -0.77 1610730.0 -20800.0 -0.09 1482160.0 -330715.3125 -1.72379349243276 1583690.0 -44352.5 -0.213850480662293 -1.4019 -0.7364 2070329 Maybridge1_001528 CCCc1nn(C)c(O)c1C(=O)c2cc3ccccc3s2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N11 compound treatment 824000.0 -996000.0 -4.88 279970.0 -1350000.0 -5.99 481530.0 -1331345.3125 -6.93939560439422 444830.0 -1183212.5 -5.70498983936944 -11.7569 -0.9922 2070330 Maybridge1_001529 Cc1cc(Sc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N12 compound treatment 1813600.0 -6730.0 -0.03 1781340.0 150000.0 0.66 1577180.0 -235695.3125 -1.22851900268273 1578000.0 -50042.5 -0.241285444530585 -0.4192 -0.2957 2070331 Maybridge1_001530 CCOC(=O)C(NC(=O)c1nn(nc1C)c2ccccc2)C(=O)OCC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N13 compound treatment 1727150.0 -93200.0 -0.46 1686340.0 54800.0 0.24 1504960.0 -307915.3125 -1.60495263402084 1532210.0 -95832.5 -0.462066990317776 -1.14 -0.6521 2070332 Maybridge1_001531 Clc1ccc(NC(=O)CC#N)cc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N14 compound treatment 1586450.0 -234000.0 -1.14 1434880.0 -197000.0 -0.87 1334350.0 -478525.3125 -2.49422626795321 1375690.0 -252352.5 -1.2167454691693 -2.8638 -0.9161 1633510 Maybridge1_001532 Clc1ccc(NC(=O)c2cccnc2)c(Cl)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N15 compound treatment 1625920.0 -194000.0 -0.95 1458450.0 -173000.0 -0.77 1590030.0 -222845.3125 -1.16154071186723 1589160.0 -38882.5 -0.187476271108767 -1.534 -0.9041 2070333 Maybridge1_001533 N/C(=N\OS(=O)(=O)c1ccc(Cl)cc1)/c2ccc(cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N16 compound treatment 1725250.0 -95100.0 -0.47 1654910.0 23400.0 0.1 1696480.0 -116395.3125 -0.606689423360697 1603090.0 -24952.5 -0.120311236541928 -0.5443 -0.6971 2070334 Maybridge1_001534 Cc1cc(Sc2ccc(cc2[N+](=O)[O-])C(=O)O)c(C)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N17 compound treatment 1812590.0 -7740.0 -0.04 1626750.0 -4810.0 -0.02 1780260.0 -32615.3125 -0.170001391880398 1564510.0 -63532.5 -0.30632897046789 -0.2678 -0.7585 2070335 Maybridge1_001535 CN(C)/C=C\1/C(=O)NN=C1CSc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N18 compound treatment 1658660.0 -162000.0 -0.79 1580870.0 -50700.0 -0.22 1617730.0 -195145.3125 -1.01715949353345 1582590.0 -45452.5 -0.219154252236128 -1.1261 -0.8491 2070336 Maybridge1_001536 Clc1ccc(cc1)c2nnnn2c3cnccn3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N19 compound treatment 1719000.0 -101000.0 -0.5 1569770.0 -61800.0 -0.27 1772320.0 -40555.3125 -0.211387199590515 1687360.0 59317.5 0.286005882119059 -0.3476 -0.5197 2070337 Maybridge1_001537 CN(C)/C=C\1/C(=O)NN=C1CSc2ccccn2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N20 compound treatment 1787780.0 -32500.0 -0.16 1665600.0 34000.0 0.15 1794000.0 -18875.3125 -0.0983841377321612 1605780.0 -22262.5 -0.10734110423864 -0.107 -0.4063 2070338 Maybridge1_001538 COc1ccc(Br)c(c1)C(=O)NN 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N21 compound treatment 1634130.0 -186000.0 -0.91 1531100.0 -100000.0 -0.45 1647010.0 -165865.3125 -0.864542812204459 1525540.0 -102502.5 -0.494227132497303 -1.3577 -0.9552 2070339 Maybridge1_001539 CCCC(=O)c1cc2ccccc2oc1=O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N22 compound treatment 1661640.0 -159000.0 -0.78 1478820.0 -153000.0 -0.68 1518880.0 -293995.3125 -1.53239716256935 1627110.0 -932.5 -0.00449615181145568 -1.4954 -0.8098 2070340 Maybridge1_001540 [O-][N+](=O)c1ccccc1C(=O)NNC(=O)c2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N23 mock treatment 1837390.0 17100.0 0.08 1827700.0 196000.0 0.87 1855330.0 42454.6875 0.221287346759205 1607490.0 -20552.5 -0.0990961502465875 0.5378 0.593 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 N24 mock treatment 1846630.0 26300.0 0.13 1876430.0 245000.0 1.09 1884640.0 71764.6875 0.374060397638742 1556390.0 -71652.5 -0.345480447903837 0.6216 0.5153 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O01 compound treatment 1703610.0 -117000.0 -0.57 1847070.0 216000.0 0.96 1706430.0 -106445.3125 -0.554826855764266 1648980.0 20937.5 0.10095247029743 -0.0346 -0.0278 2070341 Maybridge1_001541 CS/C(=N/N=C/c1c(F)cccc1Cl)/N=C/N(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O02 compound treatment 1778320.0 -42000.0 -0.21 1784640.0 153000.0 0.68 1692590.0 -120285.3125 -0.626965341747643 1677020.0 48977.5 0.236150429325008 0.0413 0.0423 2070342 Maybridge1_001542 COc1ccc(CCNC(=O)OC(C)(C)C(=O)C)cc1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O03 compound treatment 1199260.0 -621000.0 -3.04 1554410.0 -77100.0 -0.34 1362140.0 -450735.3125 -2.3493759409678 1510520.0 -117522.5 -0.566647722532761 -3.1486 -0.8078 2070343 Maybridge1_001543 Cc1ccc(N(CC=C)C2=NC(C)(C)C(=C)S2)c(C)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O04 compound treatment 1741970.0 -78400.0 -0.38 1692980.0 61400.0 0.27 1669670.0 -143205.3125 -0.746431678361733 1561400.0 -66642.5 -0.321324179190279 -0.5894 -0.6277 2070344 Maybridge1_001544 CC(C)(C)SCCNc1nc(Oc2ccc(Cl)cc2)nc(Oc3ccc(Cl)cc3)n1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O05 compound treatment 1454840.0 -365000.0 -1.79 1436010.0 -196000.0 -0.87 1218500.0 -594375.3125 -3.09807334896291 1157360.0 -470682.5 -2.26944769436513 -4.0116 -0.9277 2070345 Maybridge1_001545 COC(=O)c1sc2ccccc2c1OS(=O)(=O)c3ccc(C)cc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O06 compound treatment 1770150.0 -50200.0 -0.25 1675740.0 44200.0 0.2 1471520.0 -341355.3125 -1.77925255969166 1574820.0 -53222.5 -0.25661816598949 -1.0427 -0.5714 2070346 Maybridge1_001546 OCCCCCNc1ccc(cn1)[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O07 compound treatment 1788860.0 -31500.0 -0.15 1741940.0 110000.0 0.49 1495760.0 -317115.3125 -1.65290596285372 1656490.0 28447.5 0.137162765315159 -0.5901 -0.3399 2070347 Maybridge1_001547 CSc1ncc(C#N)c2nc(nn12)c3ccc(cc3)N(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O08 compound treatment 1732660.0 -87700.0 -0.43 1590330.0 -41200.0 -0.18 1671380.0 -141495.3125 -0.737518613980839 1573440.0 -54602.5 -0.263271988509393 -0.8063 -0.8847 2070348 Maybridge1_001548 CSC1=NCCCN1C(=O)c2nn(nc2C)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O09 compound treatment 1711910.0 -108000.0 -0.53 1838750.0 207000.0 0.92 1822880.0 10004.6875 0.0521476162562729 1659630.0 31587.5 0.152302622353197 0.2964 0.2762 1555636 Maybridge1_001549 Clc1ccc(cc1)S(=O)(=O)Nc2ccc3oc4ncccc4c(=O)c3c2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O10 compound treatment 1638410.0 -182000.0 -0.89 1494930.0 -137000.0 -0.61 1550250.0 -262625.3125 -1.36888673588593 1499870.0 -128172.5 -0.617997874588528 -1.7415 -0.9423 2070349 Maybridge1_001550 Cc1cc(Oc2ccc(cc2[N+](=O)[O-])C(F)(F)F)n(n1)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O11 compound treatment 1767170.0 -53200.0 -0.26 1725940.0 94400.0 0.42 1800960.0 -11915.3125 -0.0621064020064167 1667680.0 39637.5 0.191116587052627 0.1437 0.2701 2070350 Maybridge1_001551 CCOC(=O)/C(=C/Nc1ccc2oc3ncccc3c(=O)c2c1)/C#N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O12 compound treatment 1682370.0 -138000.0 -0.68 1438200.0 -193000.0 -0.86 1591740.0 -221135.3125 -1.15262764748634 1573300.0 -54742.5 -0.263947013982426 -1.4746 -0.9164 2070351 Maybridge1_001552 COC(=O)CSc1cc(C)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O13 compound treatment 669980.0 -1150000.0 -5.63 741650.0 -890000.0 -3.95 677860.0 -1135015.3125 -5.91606114246384 718920.0 -909122.5 -4.38343461148538 -9.9376 -0.9865 2070352 Maybridge1_001553 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1Oc2ccc(F)cc2F)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O14 compound treatment 1482370.0 -338000.0 -1.65 1604640.0 -26900.0 -0.12 1586620.0 -226255.3125 -1.17931471744551 1565370.0 -62672.5 -0.302182385419256 -1.6273 -0.7911 2070353 Maybridge1_001554 [O-][N+](=O)c1cc(ccc1SCC(=O)Nc2ccc(F)cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O15 compound treatment 1836240.0 15900.0 0.08 1704180.0 72600.0 0.32 1696890.0 -115985.3125 -0.604552372836623 1662580.0 34537.5 0.166526373392118 -0.019 -0.0269 1047215 Maybridge1_001555 COc1cc(C(=O)O)c(N)c(OC)c1OC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O16 compound treatment 1796070.0 -24300.0 -0.12 1742440.0 111000.0 0.49 1682130.0 -130745.3125 -0.681486191703288 1599460.0 -28582.5 -0.137813682735584 -0.2231 -0.2595 1739779 Maybridge1_001556 Fc1ccccc1C(=O)NC(=O)NCC2CC2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O17 compound treatment 1744690.0 -75600.0 -0.37 1650040.0 18500.0 0.08 1661190.0 -151685.3125 -0.790632137981605 1493980.0 -134062.5 -0.646397160561155 -0.8626 -0.7919 2070354 Maybridge1_001557 [O-][N+](=O)c1ccc(o1)c2nc3ccccc3c(=O)o2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O18 compound treatment 1860320.0 40000.0 0.2 1751530.0 120000.0 0.53 1792200.0 -20675.3125 -0.107766310764681 1573820.0 -54222.5 -0.261439776511159 0.1793 0.283 1274234 Maybridge1_001558 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O19 compound treatment 1723150.0 -97200.0 -0.48 1668480.0 36900.0 0.16 1753340.0 -59535.3125 -0.310317001900088 1587040.0 -41002.5 -0.197698085414704 -0.4099 -0.6578 2070355 Maybridge1_001559 Fc1ccc(NC(=O)/C(=C/c2cc(Br)cs2)/C#N)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O20 compound treatment 1792400.0 -27900.0 -0.14 1738920.0 107000.0 0.48 1779000.0 -33875.3125 -0.176568913003162 1611400.0 -16642.5 -0.0802436531068644 0.0413 0.0777 1128554 Maybridge1_001560 Cc1nn(nc1C(=O)NC(=O)N2CCCC2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O21 compound treatment 1748350.0 -72000.0 -0.35 1704110.0 72600.0 0.32 1713460.0 -99415.3125 -0.518184257753923 1591790.0 -36252.5 -0.17479543543678 -0.3617 -0.4984 2070356 Maybridge1_001561 Fc1ccc(cc1Cl)S(=O)(=O)NC(=N)CSc2ccc(Cl)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O22 compound treatment 1662430.0 -158000.0 -0.77 1418850.0 -213000.0 -0.94 1835100.0 22224.6875 0.115842146510382 1677140.0 49097.5 0.236729022587609 -0.6817 -0.5464 2070357 Maybridge1_001562 COC(=O)c1sccc1OC(=O)c2cccnc2Oc3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O23 mock treatment 1951750.0 131000.0 0.64 1725560.0 94000.0 0.42 1854890.0 42014.6875 0.218993926684589 1700090.0 72047.5 0.347384984059896 0.8132 0.9352 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 O24 mock treatment 1918310.0 98000.0 0.48 1822890.0 191000.0 0.85 1897760.0 84884.6875 0.442446014409111 1683230.0 55187.5 0.266092630664569 1.0183 0.9232 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P01 compound treatment 1701800.0 -119000.0 -0.58 1771780.0 140000.0 0.62 1654090.0 -158785.3125 -0.827639598276546 1111200.0 -516842.5 -2.49201323604534 -1.6389 -0.5938 2070358 Maybridge1_001563 Fc1cccc(Cl)c1CN(NC(=O)C(Cl)(Cl)Cl)c2ccccc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P02 compound treatment 1790360.0 -30000.0 -0.15 1729330.0 97800.0 0.43 1728000.0 -84875.3125 -0.442397148924566 1453160.0 -174882.5 -0.843215302055654 -0.4993 -0.4726 1489801 Maybridge1_001564 CSc1ncccc1C(=O)N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P03 compound treatment 1784920.0 -35400.0 -0.17 1730290.0 98700.0 0.44 1790560.0 -22315.3125 -0.116314512860978 1503600.0 -124442.5 -0.600013267342706 -0.2259 -0.2927 2070359 Maybridge1_001565 Nc1nnc(Sc2nc3c(Cl)cc(Cl)cc3s2)s1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P04 compound treatment 1839860.0 19500.0 0.1 1776340.0 145000.0 0.64 1442940.0 -369935.3125 -1.92822061817467 1525560.0 -102482.5 -0.49413070028687 -0.8423 -0.4023 2070360 Maybridge1_001566 Cc1cc(c(C)cc1Cl)S(=O)(=O)Oc2ccc(OCc3ccccc3)cc2 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P05 compound treatment 1768070.0 -52300.0 -0.26 1715330.0 83800.0 0.37 1491040.0 -321835.3125 -1.67750810547233 1587690.0 -40352.5 -0.19456403857562 -0.8781 -0.5024 1602461 Maybridge1_001567 Cc1ccc2nc3sc4ccc(Cl)cc4n3c(=O)c2c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P06 compound treatment 1764860.0 -55500.0 -0.27 1786400.0 155000.0 0.69 1635210.0 -177665.3125 -0.926048168750979 1696910.0 68867.5 0.332052262600991 -0.0894 -0.0727 2070361 Maybridge1_001568 CC(C)(C)c1cn2nc(sc2n1)C(C)(C)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P07 compound treatment 1805460.0 -14900.0 -0.07 1819420.0 188000.0 0.83 1696510.0 -116365.3125 -0.606533053810155 1648260.0 20217.5 0.0974809107218286 0.1257 0.1211 2070362 Maybridge1_001569 CN(C)/C=C/1\C(=NN(C)C1=O)C 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P08 compound treatment 1482830.0 -337000.0 -1.65 1689470.0 57900.0 0.26 1565150.0 -247725.3125 -1.29122319245007 1521660.0 -106382.5 -0.512934981321376 -1.5994 -0.7359 2070363 Maybridge1_001570 Cc1nn(nc1C(=O)NNC(=O)c2ccccc2)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P09 compound treatment 1737780.0 -82500.0 -0.4 1655920.0 24400.0 0.11 1717570.0 -95305.3125 -0.496761629329669 1596680.0 -31362.5 -0.151217759985822 -0.4719 -0.7079 2070364 Maybridge1_001571 Cc1n[nH]c2oc(=O)c([N+](=O)[O-])c(C)c12 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P10 compound treatment 1626280.0 -194000.0 -0.95 1477300.0 -154000.0 -0.68 1680810.0 -132065.3125 -0.688366451927136 1506240.0 -121802.5 -0.587284215565501 -1.4546 -0.9833 2070365 Maybridge1_001572 Clc1cccc(NC(=O)CC#N)c1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P11 compound treatment 1837760.0 17400.0 0.09 1685640.0 54100.0 0.24 1831300.0 18424.6875 0.0960353367750616 1698590.0 70547.5 0.340152568277393 0.3807 0.8739 2070366 Maybridge1_001573 Cc1cc(Sc2ccc(cc2[N+](=O)[O-])C(F)(F)F)c(Cl)cc1Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P12 compound treatment 1617950.0 -202000.0 -0.99 1615870.0 -15700.0 -0.07 1853290.0 40414.6875 0.210654217322349 1615650.0 -12392.5 -0.0597518083897742 -0.4545 -0.4471 2070367 Maybridge1_001574 CCOC(=O)C(NC(=O)c1cc2ccccc2s1)C(=O)OCC 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P13 compound treatment 1633120.0 -187000.0 -0.92 1753500.0 122000.0 0.54 1725960.0 -86915.3125 -0.453030278361422 1739420.0 111377.5 0.53701892587711 -0.1457 -0.1142 1008534 Maybridge1_001575 O=C(CC#N)Nc1ccccc1 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P14 compound treatment 1795140.0 -25200.0 -0.12 1761930.0 130000.0 0.58 1748530.0 -64345.3125 -0.335388253170323 1628680.0 637.5 0.00307377670756353 0.0613 0.0902 1518071 Maybridge1_001576 CCCC1=NN(C(=O)C1)c2ccc(cc2)S(=O)(=O)N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P15 compound treatment 1731940.0 -88400.0 -0.43 1687040.0 55500.0 0.25 1700960.0 -111915.3125 -0.583338237146424 1600260.0 -27782.5 -0.133956394318249 -0.4519 -0.5805 2070368 Maybridge1_001577 Cc1ccc(cc1)S(=O)(=O)O/N=C(\N)/c2ccc(cc2)C(F)(F)F 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P16 compound treatment 1846030.0 25700.0 0.13 1843580.0 212000.0 0.94 1785530.0 -27345.3125 -0.14253247416852 1741890.0 113847.5 0.54892830386563 0.7362 0.6661 2070369 Maybridge1_001578 Cc1ccc(cc1)S(=O)(=O)c2ccc(cc2[N+](=O)[O-])C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P17 compound treatment 1799960.0 -20400.0 -0.1 1774670.0 143000.0 0.63 1716670.0 -96205.3125 -0.501452715845929 1647810.0 19767.5 0.0953111859870778 0.0644 0.0785 1484466 Maybridge1_001579 CCCSc1ncccc1C(=O)O 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P18 compound treatment 1808870.0 -11500.0 -0.06 1757660.0 126000.0 0.56 1740720.0 -72155.3125 -0.376096459494757 1417770.0 -210272.5 -1.01385209841749 -0.4434 -0.3638 2070370 Maybridge1_001580 Cc1cc(=O)oc2n(nc(c12)C(F)(F)F)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P19 compound treatment 1806400.0 -13900.0 -0.07 1758650.0 127000.0 0.56 1747300.0 -65575.3125 -0.341799404742545 1810410.0 182367.5 0.879305056810341 0.5165 0.4691 2070371 Maybridge1_001581 CN(C)/C=C\1/C(=O)NN=C1CSc2cc(C)c(Cl)cc2Cl 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P20 compound treatment 1419750.0 -401000.0 -1.96 1528200.0 -103000.0 -0.46 1473120.0 -339755.3125 -1.77091285032942 1475440.0 -152602.5 -0.735789819632885 -2.4626 -0.8857 2070372 Maybridge1_001582 CC(C)(C)c1ccc(cc1)C(=O)NNC(=O)c2ccccc2N 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P21 compound treatment 1726580.0 -93700.0 -0.46 1681700.0 50100.0 0.22 1717280.0 -95595.3125 -0.498273201651575 1666010.0 37967.5 0.183064497481441 -0.2758 -0.3747 1740892 Maybridge1_001583 CCCc1cc(=O)oc2n(nc(C)c12)c3ccccc3 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P22 compound treatment 1304570.0 -516000.0 -2.52 1396670.0 -235000.0 -1.04 1606050.0 -206825.3125 -1.07803937187781 1374820.0 -253222.5 -1.22094027032315 -2.9322 -0.9223 2070373 Maybridge1_001584 CC(C)(C)c1ccc(cc1)C(=O)NNC(=O)c2ccccc2[N+](=O)[O-] 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P23 mock treatment 1818750.0 -1580.0 -0.01 1549300.0 -82300.0 -0.36 1835370.0 22494.6875 0.11724947246526 1512420.0 -115622.5 -0.557486662541591 -0.4064 -0.6007 1054.0018 CellTiterGlo(1054.0018) KRasSyntheticLethal 1054.0018.545 P24 mock treatment 1809440.0 -10900.0 -0.05 1770240.0 139000.0 0.62 1794280.0 -18595.3125 -0.0969246885937692 1812550.0 184507.5 0.889623303326711 0.6772 0.6229