ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B RAW_VALUE_C BSUB_VALUE_C Z_SCORE_C COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A01 compound treatment 9021280.0 -2050000.0 -1.15 9751280.0 -2350000.0 -1.32 9011880.0 -2307000.0 -1.35461240167643 -2.2113 -0.9976 2077234 Maybridge3_003873 N/C(=N/O)/c1nccnc1Sc2ccc(Cl)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A02 compound treatment 1.021244E7 -862000.0 -0.48 1.122204E7 -878000.0 -0.49 1.091932E7 -399560.0 -0.234611587002095 -0.7004 -0.9586 2077235 Maybridge3_003874 CSC(C)c1ccn(n1)S(=O)(=O)c2ccc(Cl)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A03 compound treatment 1.111916E7 44800.0 0.03 1.163572E7 -464000.0 -0.26 1.086184E7 -457040.0 -0.268362397946334 -0.2914 -0.7759 1138417 Maybridge3_003875 Cc1onc(c1C(=O)Nc2cccc3nsnc23)c4ccccc4Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A04 compound treatment 1.126564E7 191000.0 0.11 1.209956E7 -619.0 0.0 1.142428E7 105400.0 0.0618882302283031 0.0976 0.7868 2077236 Maybridge3_003876 N/C(=N\O)/c1nccnc1Oc2cccc(c2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A05 compound treatment 1.118164E7 107000.0 0.06 1.157868E7 -521000.0 -0.29 1.089284E7 -426040.0 -0.250159977290951 -0.2791 -0.715 1656884 Maybridge3_003877 Cn1nc(cc1NC(=O)C2COc3ccccc3O2)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A06 compound treatment 1.163124E7 557000.0 0.31 1.304788E7 948000.0 0.53 1.18922E7 573320.0 0.336639090649817 0.6829 0.97 2077237 Maybridge3_003878 COC(=O)CSc1cc(nc2cc(nn12)C(C)(C)C)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A07 compound treatment 1.14332E7 359000.0 0.2 1.27304E7 630000.0 0.35 1.127452E7 -44360.0 -0.0260470767829936 0.3061 0.7488 2077238 Maybridge3_003879 Cn1cnc(c1)S(=O)(=O)N=S(=O)(C)c2ccc(Cl)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A08 compound treatment 1.128052E7 206000.0 0.12 1.21778E7 77600.0 0.04 1.102216E7 -296720.0 -0.17422652441501 -0.0085 -0.0398 1063968 Maybridge3_003880 C(c1ccccc1)n2ccnc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A09 compound treatment 1.098948E7 -84900.0 -0.05 1.24036E7 303000.0 0.17 1.16058E7 286920.0 0.16847221078847 0.1684 0.6883 1573915 Maybridge3_003881 O=C(Oc1ccccc1)c2csc(n2)C3COc4ccccc4O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A10 compound treatment 8438840.0 -2640000.0 -1.48 6688160.0 -5410000.0 -3.05 6700880.0 -4618000.0 -2.71157350279226 -4.1791 -0.9632 2077239 Maybridge3_003882 O=S(=O)(C1CS(=O)(=O)c2ccccc12)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A11 compound treatment 1.216532E7 1090000.0 0.61 1.18422E7 -258000.0 -0.15 1.106064E7 -258240.0 -0.151632035807941 0.1824 0.2816 1240503 Maybridge3_003883 O=C(Oc1ccccc1)c2ccc3OCCc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A12 compound treatment 1.105236E7 -22000.0 -0.01 1.130332E7 -797000.0 -0.45 1.067496E7 -643920.0 -0.378093635755303 -0.4844 -0.8255 2077240 Maybridge3_003884 COc1cc(nc2ccc(C)c(N)c12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A13 compound treatment 1.169264E7 618000.0 0.35 1.267908E7 579000.0 0.33 1.093056E7 -388320.0 -0.228011741577369 0.257 0.4867 2077241 Maybridge3_003885 Cn1c(SCc2ccc(Br)cc2F)nnc1C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A14 compound treatment 1.149268E7 418000.0 0.23 1.191028E7 -190000.0 -0.11 1.087276E7 -446120.0 -0.261950448476761 -0.0773 -0.2102 2077242 Maybridge3_003886 COc1cc(nc2ccc(C)c(NC(=O)c3ccccc3)c12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A15 compound treatment 1.100044E7 -73900.0 -0.04 1.197564E7 -125000.0 -0.07 1.079888E7 -520000.0 -0.305330927122558 -0.2407 -0.7618 1654432 Maybridge3_003887 Brc1cc2CCOc2c(c1)C(=O)N3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A16 compound treatment 1.144428E7 370000.0 0.21 1.283448E7 734000.0 0.41 1.100044E7 -318440.0 -0.186979962370976 0.2507 0.5023 2077243 Maybridge3_003888 C/S(=N\S(=O)(=O)c1cccc2nsnc12)/c3ncccc3C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A17 compound treatment 1.155536E7 481000.0 0.27 1.238824E7 288000.0 0.16 1.096128E7 -357600.0 -0.209973729882744 0.1284 0.339 1415267 Maybridge3_003889 N#CCOc1ccc2nonc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A18 compound treatment 1.079376E7 -281000.0 -0.16 1.137448E7 -726000.0 -0.41 1.026452E7 -1054360.0 -0.619093685232577 -0.6843 -0.9024 2077244 Maybridge3_003890 O=S(=O)(/C(=C/NC1CCN(Cc2ccccc2)CC1)/C#N)c3ccccn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A19 compound treatment 1.159756E7 523000.0 0.29 1.21332E7 33000.0 0.02 1.103096E7 -287920.0 -0.169059385648321 0.0828 0.2438 1645474 Maybridge3_003891 Clc1ccc(C(=O)Oc2ccc3c(=O)ccoc3c2)c(Cl)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A20 compound treatment 1.102672E7 -47600.0 -0.03 1.150728E7 -593000.0 -0.33 1.146444E7 145560.0 0.0854691725999222 -0.1588 -0.4595 1580603 Maybridge3_003892 O=S(=O)(CCN1CCC(CC1)n2cccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A21 compound treatment 1.047956E7 -595000.0 -0.33 1.154972E7 -550000.0 -0.31 1.079852E7 -520360.0 -0.305542310072104 -0.5482 -0.9992 2077245 Maybridge3_003893 COC(=O)c1scc2c(OC)cc(nc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A22 compound treatment 1.050796E7 -566000.0 -0.32 1.107164E7 -1030000.0 -0.58 1.019288E7 -1126000.0 -0.661158892192308 -0.8997 -0.9626 1330270 Maybridge3_003894 O=C(Nc1ccc(cc1)N2CCC(CC2)n3cccc3)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A23 mock treatment 9600880.0 -1470000.0 -0.83 1.07224E7 -1380000.0 -0.78 1.019468E7 -1124200.0 -0.660101977444576 -1.3067 -0.9957 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 A24 mock treatment 8665480.0 -2410000.0 -1.35 9635240.0 -2460000.0 -1.39 8447960.0 -2870920.0 -1.68573204864364 -2.5555 -0.9949 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B01 compound treatment 1.094628E7 -128000.0 -0.07 1.18932E7 -207000.0 -0.12 1.14024E7 83520.0 0.0490408442947616 -0.0805 -0.5534 2077246 Maybridge3_003895 CSc1nn(cc1C(=O)Sc2cccs2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B02 compound treatment 1.23466E7 1270000.0 0.71 1.298388E7 884000.0 0.5 1.17468E7 427920.0 0.251263866027471 0.8448 0.9323 1229384 Maybridge3_003896 COc1c(I)cc(Cl)c2cccnc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B03 compound treatment 1.070152E7 -373000.0 -0.21 1.194708E7 -153000.0 -0.09 1.134808E7 29200.0 0.0171455059076513 -0.1608 -0.7079 1462132 Maybridge3_003897 CCOC(=O)c1c(SC)nc2c(Cl)cccc2c1N(C)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B04 compound treatment 1.236344E7 1290000.0 0.72 1.265328E7 553000.0 0.31 1.262624E7 1307360.0 0.767648924774899 1.041 0.9462 2077247 Maybridge3_003898 FC(F)(F)c1cccc(NC(=O)c2ccc3ncccc3c2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B05 compound treatment 1.251684E7 1440000.0 0.81 1.310996E7 1010000.0 0.57 1.23548E7 1035920.0 0.608266180816924 1.1471 0.9875 2077248 Maybridge3_003899 Cc1ccc2nc(cc(N3CCN(CCS(=O)(=O)c4ccc(Cl)cc4)CC3)c2c1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B06 compound treatment 1.254328E7 1470000.0 0.83 1.401656E7 1920000.0 1.08 1.234432E7 1025440.0 0.602112588285684 1.4468 0.9739 2077249 Maybridge3_003900 FC(F)(F)c1c2CCCc2nc3cc(nn13)c4ccco4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B07 compound treatment 1.318652E7 2110000.0 1.19 1.315124E7 1050000.0 0.59 1.253164E7 1212760.0 0.712102183032987 1.4377 0.9554 1557957 Maybridge3_003901 O=C(Oc1ccccc1)c2c(nnc3ccccc23)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B08 compound treatment 1.334016E7 2270000.0 1.27 1.309896E7 999000.0 0.56 1.264036E7 1321480.0 0.775939833795996 1.5074 0.9462 2077250 Maybridge3_003902 CCOC(=O)N1CCN(CC1)c2cc(nc3ccccc23)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B09 compound treatment 1.31522E7 2080000.0 1.17 1.339104E7 1290000.0 0.73 1.251668E7 1197800.0 0.703318047129615 1.4994 0.971 2077251 Maybridge3_003903 COc1ccc(cc1OC)S(=O)(=O)N(CCC#N)Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B10 compound treatment 1.307516E7 2000000.0 1.12 1.373832E7 1640000.0 0.92 1.324516E7 1926280.0 1.13106318903392 1.8342 0.9958 2077252 Maybridge3_003904 FC(F)(F)c1cc(N2CCN(CCOC(=O)C3CC3)CC2)c4cccc(Cl)c4n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B11 compound treatment 1.377516E7 2700000.0 1.52 1.370872E7 1610000.0 0.91 1.280172E7 1482840.0 0.870686369181565 1.9013 0.9653 2077253 Maybridge3_003905 Oc1ccnc2ccc(OC(F)(F)F)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B12 compound treatment 1.374276E7 2670000.0 1.5 1.299988E7 900000.0 0.51 1.313212E7 1813240.0 1.06468894287636 1.7724 0.9295 1672604 Maybridge3_003906 O=C(N1CCOCC1)c2ccc3snnc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B13 compound treatment 1.395836E7 2880000.0 1.62 1.365556E7 1560000.0 0.88 1.257892E7 1260040.0 0.739863810406746 1.8679 0.9413 2077254 Maybridge3_003907 OC1(CC(=NO1)c2cccs2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B14 compound treatment 1.322068E7 2150000.0 1.21 1.432248E7 2220000.0 1.25 1.265172E7 1332840.0 0.782610140203904 1.8701 0.9815 2077255 Maybridge3_003908 Cc1ccc2nc(cc(N3CCC(CC3)C(=O)O)c2c1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B15 compound treatment 1.256296E7 1490000.0 0.84 1.191968E7 -180000.0 -0.1 1.16806E7 361720.0 0.21239289030533 0.5467 0.6294 2077256 Maybridge3_003909 COc1ccc(cc1OC2CCCC2)/C(=N/O)/N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B16 compound treatment 1.343728E7 2360000.0 1.33 1.340952E7 1310000.0 0.74 1.279156E7 1472680.0 0.864720672605478 1.691 0.9679 1012681 Maybridge3_003910 OC(=O)CSc1ccnc2cc(Cl)ccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B17 compound treatment 1.290272E7 1830000.0 1.03 1.329536E7 1200000.0 0.67 1.213156E7 812680.0 0.47718526510377 1.2568 0.9542 2077257 Maybridge3_003911 Fc1cccc(OC(=O)c2ccc3nonc3c2)c1F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B18 compound treatment 1.257928E7 1500000.0 0.85 1.342808E7 1330000.0 0.75 1.223488E7 916000.0 0.537852171623583 1.2301 0.9841 2077258 Maybridge3_003912 CN(C(=O)c1cc2c(C)cc(C)cc2[nH]1)c3ccc(F)cc3F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B19 compound treatment 1.279608E7 1720000.0 0.97 1.311096E7 1010000.0 0.57 1.26652E7 1346320.0 0.790525257314697 1.3432 0.9787 2077259 Maybridge3_003913 CN(C)S(=O)(=O)c1ccc(s1)c2cc(on2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B20 compound treatment 1.204264E7 968000.0 0.54 1.276644E7 666000.0 0.38 1.188748E7 568600.0 0.33386762531132 0.7233 0.9771 1360569 Maybridge3_003914 CS(=O)(=O)N1CCN(CC1)c2ccnc3cc(Cl)ccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B21 compound treatment 1.327356E7 2200000.0 1.24 1.286884E7 769000.0 0.43 1.19778E7 658920.0 0.386901258653069 1.1864 0.8692 1729595 Maybridge3_003915 O=S(=O)(N1CCN(CC1)c2ccccc2)c3cccc4nsnc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B22 compound treatment 1.121376E7 139000.0 0.08 1.141088E7 -689000.0 -0.39 1.037392E7 -944960.0 -0.55485675556487 -0.4992 -0.7324 2077260 Maybridge3_003916 C/C=C/C(=O)N1CCN(CC1)c2ccnc3cc(Cl)ccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B23 mock treatment 1.161744E7 543000.0 0.31 1.211928E7 19100.0 0.01 1.11932E7 -125680.0 -0.0737961363860829 0.1397 0.4449 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 B24 mock treatment 9975520.0 -1100000.0 -0.62 1.142144E7 -679000.0 -0.38 1.009452E7 -1224360.0 -0.71891341140726 -0.992 -0.971 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C01 compound treatment 1.019568E7 -879000.0 -0.49 1.216204E7 61900.0 0.03 1.182464E7 505760.0 0.296969557118279 -0.0934 -0.1618 1646562 Maybridge3_003917 CS(=O)(=NS(=O)(=O)c1cccc2nsnc12)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C02 compound treatment 1.163548E7 561000.0 0.32 1.235376E7 254000.0 0.14 1.199908E7 680200.0 0.3993963396707 0.495 0.9367 2077261 Maybridge3_003918 COC(=O)c1csc(c1OC)S(=O)(=O)Nc2ccc(Cl)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C03 compound treatment 1.163512E7 561000.0 0.31 1.303084E7 931000.0 0.52 1.277848E7 1459600.0 0.857040425438626 0.9791 0.9301 2077262 Maybridge3_003919 FC(F)(F)c1ccc(SCC(=O)Nc2cccc3nsnc23)nc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C04 compound treatment 1.351428E7 2440000.0 1.37 1.40836E7 1980000.0 1.12 1.252164E7 1202760.0 0.706230434434477 1.8436 0.9685 1615428 Maybridge3_003920 COC(=O)c1csc(c1OC)S(=O)(=O)N2CCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C05 compound treatment 1.231972E7 1250000.0 0.7 1.28386E7 738000.0 0.42 1.2293E7 974120.0 0.571978774478127 0.9741 0.9794 2077263 Maybridge3_003921 N/C(=N\O)/c1ccc2nonc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C06 compound treatment 1.323576E7 2160000.0 1.21 1.370144E7 1600000.0 0.9 1.35082E7 2189320.0 1.28551366416915 1.9635 0.9893 2077264 Maybridge3_003922 COC(=O)c1scc2c(Oc3ccccc3)cc(nc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C07 compound treatment 1.33802E7 2310000.0 1.3 1.385352E7 1750000.0 0.99 1.288144E7 1562560.0 0.917495949008893 1.8473 0.9884 1678019 Maybridge3_003923 O=C(Sc1ccccn1)c2csc(n2)C3COc4ccccc4O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C08 compound treatment 1.419444E7 3120000.0 1.75 1.371096E7 1610000.0 0.91 1.280444E7 1485560.0 0.87228348480036 2.0389 0.9451 2077265 Maybridge3_003924 Cn1c(SCc2nccn2Cc3ccc(Cl)cc3)nnc1C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C09 compound treatment 1.273068E7 1660000.0 0.93 1.122272E7 -877000.0 -0.49 1.102272E7 -296160.0 -0.173897706493494 0.1516 0.142 1626824 Maybridge3_003925 CCOC(=O)c1sc(nc1C)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C10 compound treatment 1.365584E7 2580000.0 1.45 1.4308E7 2210000.0 1.24 1.27614E7 1442520.0 0.84701147883237 2.0437 0.9783 1922402 Maybridge3_003926 COC(=O)c1ccc(C#CC(C)(C)O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C11 compound treatment 1.281892E7 1740000.0 0.98 1.363716E7 1540000.0 0.87 1.205336E7 734480.0 0.431268191063416 1.3142 0.9548 2077266 Maybridge3_003927 C(Sc1cccs1)c2ccc3nonc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C12 compound treatment 1.300968E7 1940000.0 1.09 1.317588E7 1080000.0 0.61 1.179264E7 473760.0 0.278179961603044 1.1378 0.8924 2077267 Maybridge3_003928 Clc1ccc(CSc2nccnc2C#N)c(Cl)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C13 compound treatment 1.409112E7 3020000.0 1.69 1.477748E7 2680000.0 1.51 1.371208E7 2393200.0 1.40522687459559 2.6597 0.997 2077268 Maybridge3_003929 Fc1cc(Br)ccc1CS(=O)(=O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C14 compound treatment 1.32896E7 2220000.0 1.24 1.383592E7 1740000.0 0.98 1.252432E7 1205440.0 0.707804063058877 1.6911 0.9758 2077269 Maybridge3_003930 CCOC(=O)c1cncc(C#CCOC(=O)c2ccc(Cl)cc2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C15 compound treatment 1.304812E7 1970000.0 1.11 1.319864E7 1100000.0 0.62 1.135552E7 36640.0 0.0215140868649433 1.0095 0.7951 1249394 Maybridge3_003931 NC(=O)c1cc(Br)cc2CCOc21 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C16 compound treatment 1.301528E7 1940000.0 1.09 1.362508E7 1520000.0 0.86 1.255684E7 1237960.0 0.726898989501234 1.5447 0.9861 2077270 Maybridge3_003932 NC(=O)C1CCN(CC1)c2cc(ccn2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C17 compound treatment 1.297088E7 1900000.0 1.07 1.299672E7 897000.0 0.5 1.200816E7 689280.0 0.404727887398148 1.1401 0.9148 2077271 Maybridge3_003933 CC(C)(C)c1csc(n1)c2ccc3nonc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C18 compound treatment 1.320468E7 2130000.0 1.2 1.323072E7 1130000.0 0.64 1.196296E7 644080.0 0.378187583732879 1.2766 0.9073 1266206 Maybridge3_003934 OCc1sccc1Oc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C19 compound treatment 1.305876E7 1980000.0 1.11 1.37772E7 1680000.0 0.94 1.248656E7 1167680.0 0.685632340350901 1.5844 0.9819 2077272 Maybridge3_003935 CSc1nn2c(cc(nc2c1C(=O)O)C(F)(F)F)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C20 compound treatment 1.290724E7 1830000.0 1.03 1.34126E7 1310000.0 0.74 1.17598E7 440920.0 0.258897139205535 1.1704 0.9049 2077273 Maybridge3_003936 FC(F)(F)c1nnc(SC(=O)c2ccc(C#Cc3ccccc3)o2)[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C21 compound treatment 1.258188E7 1510000.0 0.85 1.31418E7 1040000.0 0.59 1.206184E7 742960.0 0.436247433874953 1.0793 0.9649 2077274 Maybridge3_003937 FC(F)(F)c1cc(Oc2ccccc2)c3cccc(C#N)c3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C22 compound treatment 1.161692E7 543000.0 0.3 1.334876E7 1250000.0 0.7 1.145936E7 140480.0 0.0824863243118787 0.6294 0.8168 1735700 Maybridge3_003938 CCOC(=O)c1c(O)c2cc(Cl)ccc2nc1SC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C23 mock treatment 1.179288E7 719000.0 0.4 1.233036E7 230000.0 0.13 1.169104E7 372160.0 0.218522995842175 0.434 0.91 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 C24 mock treatment 1.081136E7 -263000.0 -0.15 1.138896E7 -711000.0 -0.4 1.04662E7 -852680.0 -0.500672259497813 -0.6055 -0.9204 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D01 compound treatment 1.225752E7 1180000.0 0.66 1.321448E7 1110000.0 0.63 1.181324E7 494360.0 0.290275763715976 0.9134 0.9526 2077275 Maybridge3_003939 CSc1nn(cc1C(=O)Sc2ccccn2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D02 compound treatment 1.284284E7 1770000.0 0.99 1.390152E7 1800000.0 1.01 1.257616E7 1257280.0 0.738243207793557 1.5852 0.9907 1585459 Maybridge3_003940 Cc1occc1c2cc(N)n(n2)c3cccc(Cl)c3Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D03 compound treatment 1.298932E7 1910000.0 1.08 1.288044E7 780000.0 0.44 1.217072E7 851840.0 0.500179032615538 1.1634 0.9197 1370289 Maybridge3_003941 OC(=O)c1cncc(C#CCC2CCCCC2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D04 compound treatment 1.3315E7 2240000.0 1.26 1.339116E7 1290000.0 0.73 1.248364E7 1164760.0 0.683917789760136 1.541 0.9595 1614929 Maybridge3_003942 O=C(NCCc1ccccc1)c2ccc3ncccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D05 compound treatment 1.25796E7 1510000.0 0.85 1.340452E7 1300000.0 0.73 1.224696E7 928080.0 0.544945243930584 1.2267 0.985 2077276 Maybridge3_003943 O=C(Nc1ccccc1)OCC#Cc2ccc(C#N)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D06 compound treatment 1.4504E7 3430000.0 1.93 1.391464E7 1810000.0 1.02 1.323948E7 1920600.0 1.12772803582997 2.353 0.9585 2077277 Maybridge3_003944 Nc1nc(cc(n1)C(F)(F)F)c2nccs2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D07 compound treatment 1.33554E7 2280000.0 1.28 1.471768E7 2620000.0 1.47 1.276148E7 1442600.0 0.847058452821158 2.0794 0.977 1671972 Maybridge3_003945 COc1cc(NC(=O)c2c(nnc3ccccc23)c4ccccc4)cc(OC)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D08 compound treatment 1.3314E7 2240000.0 1.26 1.364932E7 1550000.0 0.87 1.216676E7 847880.0 0.497853820170528 1.5172 0.9426 2077278 Maybridge3_003946 FC(F)(F)c1cc(nc2ccnn12)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D09 compound treatment 1.362992E7 2560000.0 1.44 1.397968E7 1880000.0 1.06 1.315512E7 1836240.0 1.07819396465293 2.0621 0.9896 1510085 Maybridge3_003947 COc1ccc(cc1OC)S(=O)(=O)NC2CCc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D10 compound treatment 1.340752E7 2330000.0 1.31 1.26254E7 525000.0 0.3 1.240712E7 1088240.0 0.638987169484332 1.2962 0.8713 1241394 Maybridge3_003948 COC(=O)c1ccc2n(nnc2c1)C3CCN(Cc4ccccc4)CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D11 compound treatment 1.357872E7 2500000.0 1.41 1.421316E7 2110000.0 1.19 1.24256E7 1106720.0 0.64983816089438 1.874 0.9594 1127976 Maybridge3_003949 O=S(=O)(N(CCC#N)Cc1cccs1)c2cccc3nsnc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D12 compound treatment 1.366348E7 2590000.0 1.45 1.49484E7 2850000.0 1.6 1.318152E7 1862640.0 1.093695380953 2.3967 0.9883 2077279 Maybridge3_003950 C=CCn1c(SCC(=O)NCc2ccccc2)nnc1c3ccc4ncccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D13 compound treatment 1.39398E7 2870000.0 1.61 1.39842E7 1880000.0 1.06 1.104504E7 -273840.0 -0.160791963621618 1.4487 0.749 1480094 Maybridge3_003951 Clc1cccc2c(ccnc12)N3CCC(CC3)n4cccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D14 compound treatment 1.33592E7 2280000.0 1.28 1.369088E7 1590000.0 0.9 1.298636E7 1667480.0 0.979102335304467 1.8232 0.9877 2077280 Maybridge3_003952 Cn1c(CNC(=O)c2ccccc2)nnc1SCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D15 compound treatment 1.317508E7 2100000.0 1.18 1.402E7 1920000.0 1.08 1.210556E7 786680.0 0.461918718747642 1.5719 0.9438 1558253 Maybridge3_003953 Fc1ccc(NC(=O)c2ccc3nonc3c2)c(F)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D16 compound treatment 1.275932E7 1680000.0 0.95 1.36104E7 1510000.0 0.85 1.238636E7 1067480.0 0.626797419393823 1.3991 0.9865 1120418 Maybridge3_003954 CSc1nc2ccc(NC(=O)c3ccc4snnc4c3)cc2s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D17 compound treatment 1.296388E7 1890000.0 1.06 1.464632E7 2550000.0 1.43 1.24992E7 1180320.0 0.693054230579419 1.8404 0.9619 1459416 Maybridge3_003955 O=C(N1CCN(CC1)c2ccccc2)c3ccc4nonc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D18 compound treatment 1.30432E7 1970000.0 1.11 1.367472E7 1570000.0 0.89 1.193648E7 617600.0 0.362639193444023 1.3596 0.9294 1585700 Maybridge3_003956 COCC(C)NC(=O)c1cc2c(C)cc(C)cc2[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D19 compound treatment 1.284248E7 1770000.0 0.99 1.331184E7 1210000.0 0.68 1.320668E7 1887800.0 1.10846870042686 1.6071 0.9817 1708839 Maybridge3_003957 N#Cc1nccnc1N2CCN(Cc3ccccc3)CC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D20 compound treatment 1.277912E7 1700000.0 0.96 1.304404E7 944000.0 0.53 1.2429E7 1110120.0 0.651834555417873 1.2359 0.9698 1732100 Maybridge3_003958 Clc1ccc2c(ccnc2c1)N3CCN(CC3)C(=O)C4CCCCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D21 compound treatment 1.263356E7 1560000.0 0.88 1.270184E7 602000.0 0.34 1.175872E7 439840.0 0.258262990356896 0.8503 0.8731 1392947 Maybridge3_003959 O=S(=O)(NCCc1c[nH]c2ccccc12)c3cccc4nsnc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D22 compound treatment 1.36496E7 2580000.0 1.45 1.29982E7 898000.0 0.51 1.172944E7 410560.0 0.241070510460457 1.2662 0.8163 1736799 Maybridge3_003960 CN(C)c1ccc(cc1)C(=O)N2CCN(CC2)c3ccnc4cc(Cl)ccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D23 mock treatment 1.197192E7 898000.0 0.5 1.332884E7 1230000.0 0.69 1.189568E7 576800.0 0.338682459162099 0.8859 0.9625 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 D24 mock treatment 1.084808E7 -226000.0 -0.13 1.283052E7 730000.0 0.41 1.165272E7 333840.0 0.196022455212682 0.2772 0.5861 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E01 compound treatment 1.092016E7 -154000.0 -0.09 1.139572E7 -704000.0 -0.4 1.19444E7 625520.0 0.367289618334043 -0.0669 -0.1222 2077281 Maybridge3_003961 Clc1ccc(cc1)C(=O)N2CCSC2=S 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E02 compound treatment 1.270284E7 1630000.0 0.91 1.348912E7 1390000.0 0.78 1.27572E7 1438320.0 0.844545344420995 1.4671 0.998 2077282 Maybridge3_003962 CSc1nn(cc1c2noc(n2)c3ccc(Cl)cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E03 compound treatment 1.184284E7 768000.0 0.43 1.278272E7 683000.0 0.38 1.126388E7 -55000.0 -0.032294617291809 0.4524 0.7816 2077283 Maybridge3_003963 Clc1ccc(NS(=O)(=O)c2cccc3nonc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E04 compound treatment 1.279832E7 1720000.0 0.97 1.365224E7 1550000.0 0.87 1.323884E7 1919960.0 1.12735224391967 1.7144 0.9945 2077284 Maybridge3_003964 FC(F)(F)c1cccc(Oc2nccnc2c3noc(n3)c4cccs4)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E05 compound treatment 1.250144E7 1430000.0 0.8 1.277488E7 675000.0 0.38 9204720.0 -2114160.0 -1.24138160170274 -0.0347 -0.0227 1319212 Maybridge3_003965 CC(C)C1Oc2c(cccc2NC1=O)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E06 compound treatment 1.234472E7 1270000.0 0.71 1.398584E7 1890000.0 1.06 1.396872E7 2649840.0 1.55591943062777 1.9231 0.9548 2077285 Maybridge3_003966 COc1cc(nc2ccc(C#CCO)cc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E07 compound treatment 1.252636E7 1450000.0 0.82 1.420256E7 2100000.0 1.18 1.278372E7 1464840.0 0.860117221704246 1.6507 0.9855 2077286 Maybridge3_003967 Oc1cc(nc2[nH]nc(c3cccs3)c12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E08 compound treatment 1.30418E7 1970000.0 1.11 1.32732E7 1170000.0 0.66 1.205612E7 737240.0 0.432888793676605 1.2692 0.9345 2077287 Maybridge3_003968 C(#Cc1ccccc1)c2ccc(s2)c3cc[nH]n3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E09 compound treatment 1.289232E7 1820000.0 1.02 1.330968E7 1210000.0 0.68 1.292748E7 1608600.0 0.944529479556436 1.5279 0.9866 2077288 Maybridge3_003969 CSc1nn2c(cc(nc2c1C#N)C(F)(F)F)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E10 compound treatment 1.32498E7 2180000.0 1.22 1.35862E7 1490000.0 0.84 1.218136E7 862480.0 0.506426573124353 1.4808 0.9462 2077289 Maybridge3_003970 FC(F)(F)c1ccc(nc1)N2CCC(CC2)C(=O)Nc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E11 compound treatment 1.281936E7 1750000.0 0.98 1.291924E7 819000.0 0.46 1.244056E7 1121680.0 0.658622296797752 1.2123 0.9563 2077290 Maybridge3_003971 FC(F)(F)c1ccc(SCc2ccc3nonc3c2)nc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E12 compound treatment 1.309328E7 2020000.0 1.13 1.232696E7 227000.0 0.13 1.174888E7 430000.0 0.252485189735961 0.8742 0.748 2077291 Maybridge3_003972 FC(F)(F)c1ccc2SCC(=O)N(Cc3ccccc3)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E13 compound treatment 8461720.0 -2610000.0 -1.47 821360.0 -1.13E7 -6.35 689400.0 -1.062948E7 -6.24136342928978 -8.1163 -0.8995 1332456 Maybridge3_003973 Cc1csc(n1)c2sc3ccccc3c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E14 compound treatment 1.256444E7 1490000.0 0.84 1.320436E7 1100000.0 0.62 1.38444E7 2525520.0 1.48292185205108 1.6982 0.9369 1258662 Maybridge3_003974 CN(C)CC#Cc1ccc(s1)c2cc[nH]n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E15 compound treatment 1.295416E7 1880000.0 1.06 1.390812E7 1810000.0 1.02 1.24644E7 1145520.0 0.672620545456601 1.5855 0.9827 2077292 Maybridge3_003975 COc1c(C)cnc(CO)c1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E16 compound treatment 1.336184E7 2290000.0 1.28 1.274956E7 649000.0 0.37 1.194184E7 622960.0 0.365786450692824 1.164 0.8405 2077293 Maybridge3_003976 O=C(Nc1ccc2COC(=O)c2c1)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E17 compound treatment 1.278988E7 1720000.0 0.96 1.251712E7 417000.0 0.23 1.227164E7 952760.0 0.559436719471708 1.0148 0.8912 1718090 Maybridge3_003977 N#Cc1ccc(cc1)c2csc(COc3ccc4nonc4c3)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E18 compound treatment 1.229292E7 1220000.0 0.68 1.24176E7 317000.0 0.18 1.169748E7 378600.0 0.222304401939616 0.6267 0.8452 2077294 Maybridge3_003978 Brc1ccc(s1)c2ccn(n2)S(=O)(=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E19 compound treatment 1.301336E7 1940000.0 1.09 1.472144E7 2620000.0 1.48 1.233668E7 1017800.0 0.597626572356422 1.8257 0.9465 2077295 Maybridge3_003979 CC(C)(C)c1cc2nc(cc(C#N)n2n1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E20 compound treatment 1.226796E7 1190000.0 0.67 1.232176E7 222000.0 0.12 1.151908E7 200200.0 0.117552406942185 0.527 0.7615 1507720 Maybridge3_003980 O=C(Nc1ccccc1)c2ccc(C#Cc3ccccc3)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E21 compound treatment 1.233292E7 1260000.0 0.71 1.280816E7 708000.0 0.4 1.155848E7 239600.0 0.140687096420317 0.7195 0.8735 1264652 Maybridge3_003981 Cc1ccc(cc1)C(=O)Nc2ccc3CS(=O)(=O)Cc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E22 compound treatment 1.25214E7 1450000.0 0.81 1.30248E7 925000.0 0.52 1.192644E7 607560.0 0.356743957851118 0.9757 0.9483 1101325 Maybridge3_003982 OC1CN(C1)C(c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E23 mock treatment 1.14216E7 347000.0 0.2 1.262636E7 526000.0 0.3 1.158336E7 264480.0 0.155296006933412 0.3733 0.9641 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 E24 mock treatment 1.01648E7 -910000.0 -0.51 1.182936E7 -271000.0 -0.15 1.11462E7 -172680.0 -0.101393354799083 -0.4415 -0.8136 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F01 compound treatment 1.29718E7 1900000.0 1.07 1.23316E7 231000.0 0.13 1.221024E7 891360.0 0.523384183076852 0.9927 0.8311 2077296 Maybridge3_003983 CSc1nn(cc1C(=O)Oc2ccc(Cl)cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F02 compound treatment 1.3263E7 2190000.0 1.23 1.338116E7 1280000.0 0.72 1.223956E7 920680.0 0.540600149967686 1.4382 0.9435 2077297 Maybridge3_003984 CC(=O)Nc1c(nn2c(C)cc(nc12)C(F)(F)F)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F03 compound treatment 1.27536E7 1680000.0 0.94 1.359672E7 1500000.0 0.84 1.251124E7 1192360.0 0.700123815892025 1.4351 0.9928 2077298 Maybridge3_003985 FC(F)(F)c1cc(N2CCN(CC2)S(=O)(=O)c3ccccc3)c4ccccc4n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F04 compound treatment 1.176568E7 691000.0 0.39 1.252504E7 425000.0 0.24 1.077612E7 -542760.0 -0.318695026932768 0.1783 0.3204 1662303 Maybridge3_003986 COc1ccc(OC(=O)c2ccc3ncccc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F05 compound treatment 1.300896E7 1930000.0 1.09 1.35928E7 1490000.0 0.84 1.216576E7 846880.0 0.497266645310677 1.3996 0.9581 1634093 Maybridge3_003987 O=C(CSc1ccccc1)N2CCC(CC2)n3cccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F06 compound treatment 1.258784E7 1510000.0 0.85 1.398868E7 1890000.0 1.06 1.284088E7 1522000.0 0.893680136693333 1.6205 0.9952 2077299 Maybridge3_003988 Nc1nc(cc(n1)C(F)(F)F)c2ccc(Cl)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F07 compound treatment 1.372568E7 2650000.0 1.49 1.351492E7 1410000.0 0.8 1.272872E7 1409840.0 0.827822604412437 1.7975 0.9557 1420243 Maybridge3_003989 Cc1ccc(NC(=O)c2c(nnc3ccccc23)c4ccccc4)cc1F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F08 compound treatment 1.37242E7 2650000.0 1.49 1.263176E7 532000.0 0.3 1.357568E7 2256800.0 1.3251362237119 1.7971 0.8918 2077300 Maybridge3_003990 FC(F)(F)c1ccn(n1)c2cc(=O)c3ccccc3o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F09 compound treatment 1.333796E7 2260000.0 1.27 1.352524E7 1430000.0 0.8 1.288616E7 1567280.0 0.92026741434739 1.7285 0.9806 2077301 Maybridge3_003991 CSc1scc(NC(=O)c2ccc(C)cc2)c1S(=O)(=O)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F10 compound treatment 1.361288E7 2540000.0 1.43 1.389768E7 1800000.0 1.01 1.31204E7 1801520.0 1.05780725351891 2.0181 0.9876 2077302 Maybridge3_003992 Cn1c(CNC(=O)OC(C)(C)C)nnc1SCc2c(F)cccc2Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F11 compound treatment 1.3249E7 2170000.0 1.22 1.268888E7 589000.0 0.33 1.347952E7 2160640.0 1.26867348918862 1.629 0.909 2077303 Maybridge3_003993 CCOC(=O)c1sc(SC)c(c1N)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F12 compound treatment 1.348912E7 2410000.0 1.36 1.412888E7 2030000.0 1.14 1.300424E7 1685360.0 0.989601021798604 2.0137 0.9917 2077304 Maybridge3_003994 CC(C)NC(=O)CSc1nnc(c2ccc3ncccc3c2)n1CC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F13 compound treatment 1.31664E7 2090000.0 1.18 1.365792E7 1560000.0 0.88 1.260924E7 1290360.0 0.757666952157431 1.6221 0.9829 2077305 Maybridge3_003995 CCOC(=O)Cc1cc(=O)n2nc(cc2[nH]1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F14 compound treatment 1.376484E7 2690000.0 1.51 1.358728E7 1490000.0 0.84 1.293384E7 1614960.0 0.948263911665089 1.9033 0.9658 1423418 Maybridge3_003996 COC(=O)CSc1ccnc2cc(Cl)ccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F15 compound treatment 1.270056E7 1630000.0 0.91 1.270136E7 601000.0 0.34 1.229864E7 979760.0 0.575290440687687 1.0549 0.9325 2077306 Maybridge3_003997 FC(F)(F)c1cccc(NC(=O)c2ccc3nonc3c2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F16 compound treatment 1.327428E7 2200000.0 1.24 1.389144E7 1790000.0 1.01 1.216E7 841120.0 0.493884518117935 1.5807 0.9468 2077307 Maybridge3_003998 O=C(Nc1ccc2CS(=O)(=O)Cc2c1)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F17 compound treatment 1.357956E7 2510000.0 1.41 1.379336E7 1690000.0 0.95 1.233988E7 1021000.0 0.599505531907946 1.7088 0.9482 2077308 Maybridge3_003999 FC(F)(F)c1cc(n[nH]1)c2cccnc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F18 compound treatment 1.349608E7 2420000.0 1.36 1.338488E7 1280000.0 0.72 1.202116E7 702280.0 0.412361160576212 1.4409 0.9035 2077309 Maybridge3_004000 Cc1cc(C)c2cc([nH]c2c1)C(=O)NCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F19 compound treatment 1.263636E7 1560000.0 0.88 1.284932E7 749000.0 0.42 1.220204E7 883160.0 0.518569349226074 1.0494 0.9515 1523206 Maybridge3_004001 N#Cc1nccnc1N2CCN(CC2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F20 compound treatment 1.174176E7 667000.0 0.37 1.218964E7 89500.0 0.05 1.168776E7 368880.0 0.216597062301864 0.3706 0.8502 1149229 Maybridge3_004002 CCS(=O)(=O)N1CCN(CC1)c2ccnc3cc(Cl)ccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F21 compound treatment 1.139636E7 322000.0 0.18 1.297412E7 874000.0 0.49 1.220624E7 887360.0 0.521035483637448 0.6893 0.9326 2077310 Maybridge3_004003 CN(C)S(=O)(=O)Nc1ccc(C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F22 compound treatment 1.188008E7 806000.0 0.45 1.126776E7 -832000.0 -0.47 1.037508E7 -943800.0 -0.554175632727443 -0.3292 -0.3849 1200296 Maybridge3_004004 Clc1ccc2c(ccnc2c1)N3CCN(CC3)C(=O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F23 mock treatment 7825800.0 -3250000.0 -1.82 8718240.0 -3380000.0 -1.9 8674880.0 -2644000.0 -1.55249032944624 -3.0489 -0.9964 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 F24 mock treatment 1.079536E7 -279000.0 -0.16 1.1702E7 -398000.0 -0.22 1.09276E7 -391280.0 -0.229749779162528 -0.3525 -0.987 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G01 compound treatment 1.08294E7 -245000.0 -0.14 1.25264E7 426000.0 0.24 1.122E7 -98880.0 -0.0580598501420741 0.0256 0.0905 2077311 Maybridge3_004005 CSc1nnc(SCCS(=O)(=O)c2ccc(Cl)cc2)s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G02 compound treatment 1.258524E7 1510000.0 0.85 1.344752E7 1350000.0 0.76 1.239328E7 1074400.0 0.630860669423993 1.2921 0.9929 1162460 Maybridge3_004006 OCC#Cc1ccc(s1)c2cccnc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G03 compound treatment 1.21924E7 1120000.0 0.63 1.249856E7 398000.0 0.22 1.206996E7 751080.0 0.441015293736944 0.7467 0.9339 1636969 Maybridge3_004007 CS(=N)(=O)c1ccc(Oc2cccc(F)c2C#N)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G04 compound treatment 1.266544E7 1590000.0 0.89 1.364532E7 1550000.0 0.87 1.230844E7 989560.0 0.581044754314228 1.3536 0.9839 2077312 Maybridge3_004008 COC(=O)CSc1cc(nc2c(scc12)C(=O)OC)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G05 compound treatment 1.262272E7 1550000.0 0.87 1.177008E7 -330000.0 -0.19 1.096432E7 -354560.0 -0.208188718308796 0.2746 0.3007 1130330 Maybridge3_004009 CCOC(=O)CN1C(=O)C(Oc2c(cccc12)C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G06 compound treatment 1.28148E7 1740000.0 0.98 1.345384E7 1350000.0 0.76 1.281844E7 1499560.0 0.880503932838275 1.5127 0.9949 1729930 Maybridge3_004010 CCOC(=O)c1cn(Cc2ccccc2)c3cc(C)nn3c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G07 compound treatment 1.314448E7 2070000.0 1.16 1.372696E7 1630000.0 0.92 1.311144E7 1792560.0 1.05254616677464 1.8077 0.9953 2077313 Maybridge3_004011 CCOC(=O)c1csc(n1)c2ccc3nonc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G08 compound treatment 1.312072E7 2050000.0 1.15 1.355092E7 1450000.0 0.82 1.313844E7 1819560.0 1.06839988799062 1.7519 0.9903 2077314 Maybridge3_004012 FC(F)(F)C1CCN(CCS(=O)(=O)c2ccccc2)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G09 compound treatment 1.227864E7 1200000.0 0.68 1.203736E7 -62800.0 -0.04 1.102112E7 -297760.0 -0.174837186269256 0.2692 0.3848 1726778 Maybridge3_004013 Cc1nc(sc1C(=O)O)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G10 compound treatment 1.358528E7 2510000.0 1.41 1.424356E7 2140000.0 1.21 1.29282E7 1609320.0 0.944952245455529 2.0564 0.9874 2077315 Maybridge3_004014 CSc1ncc2c(O)ncnc2n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G11 compound treatment 1.354644E7 2470000.0 1.39 1.329012E7 1190000.0 0.67 1.484432E7 3525440.0 2.07004973791337 2.3835 0.9235 2077316 Maybridge3_004015 O=S(Cc1ccc2nonc2c1)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G12 compound treatment 1.332096E7 2250000.0 1.26 1.355888E7 1460000.0 0.82 1.272968E7 1410800.0 0.828386292277894 1.6809 0.9782 1382187 Maybridge3_004016 CCOC(=O)c1cncc(C#CC(C)(C)O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G13 compound treatment 1.39236E7 2850000.0 1.6 1.354276E7 1440000.0 0.81 1.26494E7 1330520.0 0.78124789452905 1.8439 0.9421 1638255 Maybridge3_004017 Cc1ccc(cc1)C(=O)NCC2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G14 compound treatment 1.411708E7 3040000.0 1.71 1.448224E7 2380000.0 1.34 1.278688E7 1468000.0 0.861972694261375 2.2585 0.9664 1146518 Maybridge3_004018 NC(=O)CCOC1CCN(CC1)C(c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G15 compound treatment 1.17124E7 638000.0 0.36 1.178412E7 -316000.0 -0.18 1.032472E7 -994160.0 -0.583745758669543 -0.2328 -0.329 1131426 Maybridge3_004019 CC(C)(C)NC(=O)c1cc(Br)cc2CCOc21 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G16 compound treatment 1.362132E7 2550000.0 1.43 1.356476E7 1460000.0 0.82 1.169652E7 377640.0 0.221740714074159 1.43 0.8583 1374712 Maybridge3_004020 O=C(Nc1ccc2COC(=O)c2c1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G17 compound treatment 1.281468E7 1740000.0 0.98 1.394304E7 1840000.0 1.04 1.245668E7 1137800.0 0.668087555538551 1.549 0.984 2077317 Maybridge3_004021 Cc1cc(nc2c(Cl)c(nn12)C3CC3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G18 compound treatment 1.345036E7 2380000.0 1.33 1.39396E7 1840000.0 1.04 1.240544E7 1086560.0 0.638000715719782 1.7367 0.9618 1374157 Maybridge3_004022 O=C(N1CCC(CC1)n2cccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G19 compound treatment 1.49134E7 3840000.0 2.16 1.31028E7 1000000.0 0.56 1.146916E7 150280.0 0.0882406379384193 1.6217 0.727 2077318 Maybridge3_004023 Oc1cc(nc2c(OC(F)(F)F)cccc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G20 compound treatment 1.311248E7 2040000.0 1.14 1.316692E7 1070000.0 0.6 1.15292E7 210320.0 0.123494616523878 1.0789 0.8308 1689779 Maybridge3_004024 O=C(N1CCOCC1)c2ccc(C#Cc3ccccc3)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G21 compound treatment 1.36558E7 2580000.0 1.45 1.320784E7 1110000.0 0.62 1.2223E7 904120.0 0.530876534288552 1.5036 0.903 1702398 Maybridge3_004025 COc1ccc(cc1)S(=O)(=O)Nc2ccc3CS(=O)(=O)Cc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G22 compound treatment 1.225732E7 1180000.0 0.66 1.276204E7 662000.0 0.37 1.168E7 361120.0 0.21204058538942 0.7211 0.912 1391261 Maybridge3_004026 CCOC(=O)c1c(O)c2cccc(Cl)c2nc1SC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G23 mock treatment 1.257336E7 1500000.0 0.84 1.267084E7 571000.0 0.32 1.186116E7 542280.0 0.31841318300004 0.8554 0.895 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 G24 mock treatment 1.143688E7 363000.0 0.2 1.242408E7 324000.0 0.18 1.175884E7 439960.0 0.258333451340078 0.372 0.9891 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H01 compound treatment 1.3153E7 2080000.0 1.17 1.32634E7 1160000.0 0.65 1.175584E7 436960.0 0.256571926760525 1.2003 0.8806 2077319 Maybridge3_004027 COc1ccc(OC(=O)c2cn(nc2SC)c3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H02 compound treatment 1.215468E7 1080000.0 0.61 1.413552E7 2040000.0 1.15 1.212788E7 809000.0 0.475024461619518 1.2861 0.9314 1405433 Maybridge3_004028 CC(C)N1CCC(CC1)n2nnc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H03 compound treatment 1.281112E7 1740000.0 0.98 1.305512E7 955000.0 0.54 1.260832E7 1289440.0 0.757126751286368 1.3107 0.9732 2077320 Maybridge3_004029 FC(F)(F)c1cc(N2CCN(CC2)C(=O)c3ccccc3)c4ccccc4n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H04 compound treatment 1.242024E7 1350000.0 0.76 1.316516E7 1060000.0 0.6 1.245784E7 1138960.0 0.668768678375978 1.1687 0.9955 1181065 Maybridge3_004030 O=C(N1CCN(CC1)c2ccccc2)c3ccc4ncccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H05 compound treatment 1.22278E7 1150000.0 0.65 1.290268E7 803000.0 0.45 1.21178E7 798920.0 0.469105739032219 0.9057 0.9859 2077321 Maybridge3_004031 O=C(OCC#Cc1ccc(C#N)cc1)c2cccs2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H06 compound treatment 1.373232E7 2660000.0 1.49 1.307236E7 972000.0 0.55 1.209572E7 776840.0 0.456140918126708 1.4413 0.8713 2077322 Maybridge3_004032 Nc1nc(c2CCc3ccccc3-c2n1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H07 compound treatment 1.337196E7 2300000.0 1.29 1.3858E7 1760000.0 0.99 1.294036E7 1621480.0 0.952092291751318 1.8661 0.9903 2077323 Maybridge3_004033 Cn1c(CSCC(=O)Nc2ccccc2)nnc1SCC(=O)c3ccc(F)c(F)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H08 compound treatment 1.378732E7 2710000.0 1.52 1.431176E7 2210000.0 1.24 1.241516E7 1096280.0 0.643708055357534 1.9702 0.9516 2077324 Maybridge3_004034 FC(F)(F)c1cc(nc2cc(nn12)c3cccs3)c4nccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H09 compound treatment 1.257292E7 1500000.0 0.84 1.291068E7 811000.0 0.46 1.208508E7 766200.0 0.449893377617892 1.0091 0.9539 1237588 Maybridge3_004035 CSc1scc(NS(=O)(=O)c2ccc(Cl)cc2)c1S(=O)(=O)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H10 compound treatment 1.29244E7 1850000.0 1.04 1.285676E7 757000.0 0.43 1.24764E7 1157520.0 0.679666643774814 1.2382 0.9433 1211183 Maybridge3_004036 COc1cc(NC(=O)c2ccc3snnc3c2)cc(OC)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H11 compound treatment 1.338004E7 2310000.0 1.3 1.293232E7 832000.0 0.47 1.260772E7 1288840.0 0.756774446370457 1.4551 0.926 2077325 Maybridge3_004037 Clc1ccc(cc1)S(=O)(=O)n2ncc(C#N)c2C3CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H12 compound treatment 1.36006E7 2530000.0 1.42 1.357676E7 1480000.0 0.83 1.328916E7 1970280.0 1.15689888286737 1.967 0.9783 1725990 Maybridge3_004038 O=C(NCc1ccco1)c2ccc3snnc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H13 compound treatment 1.410416E7 3030000.0 1.7 1.505848E7 2960000.0 1.67 1.217852E7 859640.0 0.504758996522376 2.2354 0.9184 1261573 Maybridge3_004039 Clc1ccc(cc1)S(=O)(=O)N(CCC(=O)Nc2ccccc2)Cc3ccco3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H14 compound treatment 1.523296E7 4160000.0 2.34 1.389096E7 1790000.0 1.01 1.267736E7 1358480.0 0.797665303610486 2.3911 0.8968 2077326 Maybridge3_004040 COC(=O)c1ccc(Cn2cnc3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H15 compound treatment 1.243604E7 1360000.0 0.76 1.29688E7 869000.0 0.49 1.244208E7 1123200.0 0.659514802584725 1.1046 0.9845 2077327 Maybridge3_004041 COc1ccc(NC(=O)c2ccc3nonc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H16 compound treatment 1.334824E7 2270000.0 1.28 1.365568E7 1560000.0 0.88 1.152556E7 206680.0 0.12135730003402 1.313 0.8453 2077328 Maybridge3_004042 CC(=O)N1CCC(CC1)c2nc(no2)c3ccc(cc3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H17 compound treatment 1.26042E7 1530000.0 0.86 1.281328E7 713000.0 0.4 1.181536E7 496480.0 0.291520574418861 0.8962 0.9032 2077329 Maybridge3_004043 COc1ccc(cc1OC2CCCC2)c3noc(n3)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H18 compound treatment 1.292236E7 1850000.0 1.04 1.14048E7 -695000.0 -0.39 1.272432E7 1405440.0 0.825239035029092 0.8497 0.6146 1331976 Maybridge3_004044 CCc1ccc2[nH]c(cc2c1)C(=O)N(C)c3ccc(F)cc3F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H19 compound treatment 1.436652E7 3290000.0 1.85 1.372836E7 1630000.0 0.92 1.222136E7 902480.0 0.529913567518396 1.9027 0.893 1661316 Maybridge3_004045 Fc1ccc(cc1)S(=O)(=O)CCN2CCN(CC2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H20 compound treatment 1.293196E7 1860000.0 1.04 1.308312E7 983000.0 0.55 1.12418E7 -77080.0 -0.0452594381973207 0.8957 0.7579 1700688 Maybridge3_004046 CC(C)S(=O)(=O)N1CCN(CC1)c2ccnc3cc(Cl)ccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H21 compound treatment 1.236572E7 1290000.0 0.73 1.24774E7 377000.0 0.21 1.172604E7 407160.0 0.239074115936963 0.6794 0.8571 1535026 Maybridge3_004047 CCOC(=O)Nc1cncc(Br)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H22 compound treatment 1.22222E7 1150000.0 0.64 1.1068E7 -1030000.0 -0.58 1.001488E7 -1304000.0 -0.765676017245799 -0.4053 -0.3502 1199932 Maybridge3_004048 Cc1cc(Nc2ccccc2)c3ccccc3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H23 mock treatment 1.203512E7 961000.0 0.54 1.282796E7 728000.0 0.41 1.280672E7 1487840.0 0.873622243480821 1.0525 0.952 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 H24 mock treatment 1.100424E7 -70100.0 -0.04 1.154268E7 -557000.0 -0.31 1.153272E7 213840.0 0.125561472030553 -0.1314 -0.3862 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I01 compound treatment 8602160.0 -2470000.0 -1.39 8782920.0 -3320000.0 -1.87 8428240.0 -2890640.0 -1.69731113687991 -2.8597 -0.9929 2077330 Maybridge3_004049 O/N=C/c1ccc2OCCc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I02 compound treatment 1.2718E7 1640000.0 0.92 1.285924E7 759000.0 0.43 1.21684E7 849520.0 0.498816786940684 1.0677 0.9424 2077331 Maybridge3_004050 CSc1nn(cc1c2noc(n2)c3cccs3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I03 compound treatment 1.1984E7 910000.0 0.51 1.238392E7 284000.0 0.16 1.21416E7 822720.0 0.483080500696675 0.6661 0.9238 2077332 Maybridge3_004051 Cc1occc1C(=O)C(=C2SCCCCS2)C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I04 compound treatment 1.212608E7 1050000.0 0.59 1.373608E7 1640000.0 0.92 1.115216E7 -166720.0 -0.0978937926343709 0.8162 0.7431 2077333 Maybridge3_004052 O/N=C/C(=O)Nc1ccccc1F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I05 compound treatment 1.215644E7 1080000.0 0.61 1.268396E7 584000.0 0.33 1.16538E7 334920.0 0.196656604061321 0.6542 0.9106 2077334 Maybridge3_004053 CCOC(=O)c1csc(n1)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I06 compound treatment 3070320.0 -8000000.0 -4.5 3724040.0 -8380000.0 -4.72 1609600.0 -9709280.0 -5.70104512325483 -8.6093 -0.9945 2077335 Maybridge3_004054 COC(=O)c1sccc1Oc2cc(nc3c(scc23)C(=O)OC)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I07 compound treatment 1.292264E7 1850000.0 1.04 1.344004E7 1340000.0 0.75 1.41462E7 2827320.0 1.66013122475414 1.9933 0.95 1167446 Maybridge3_004055 O=C(Nc1ccccc1)c2csc(n2)C3COc4ccccc4O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I08 compound treatment 1.26984E7 1620000.0 0.91 1.45834E7 2480000.0 1.4 1.2835E7 1516120.0 0.890227548517409 1.8477 0.9767 2077336 Maybridge3_004056 CC(C)(C)c1cc2nc(cc(SCCO)n2n1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I09 compound treatment 1.317476E7 2100000.0 1.18 1.398488E7 1880000.0 1.06 1.189632E7 577440.0 0.339058251072404 1.4894 0.918 2077337 Maybridge3_004057 CC1(C)Oc2ccc(cc2C=C1)/C(=N/O)/N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I10 compound treatment 1.501904E7 3940000.0 2.22 1.353624E7 1440000.0 0.81 1.268764E7 1368760.0 0.803701461169755 2.2099 0.8869 2077338 Maybridge3_004058 FC(F)(F)c1ccc(nc1)N2CCC(CC2)C(=O)Oc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I11 compound treatment 1.38084E7 2730000.0 1.54 1.264584E7 546000.0 0.31 1.180144E7 482560.0 0.283347100369734 1.2275 0.7713 2077339 Maybridge3_004059 C(SCc1ccc2nonc2c1)c3ccco3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I12 compound treatment 1.380872E7 2730000.0 1.54 1.40062E7 1910000.0 1.07 1.411204E7 2793160.0 1.64007333154162 2.4531 0.9852 2077340 Maybridge3_004060 O=S(=O)(/C(=C/c1c[nH]cn1)/C#N)c2cccs2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I13 compound treatment 1.322484E7 2150000.0 1.21 1.47498E7 2650000.0 1.49 1.261904E7 1300160.0 0.763421265783971 1.9993 0.9679 1742782 Maybridge3_004061 CC(C)(C)C(=O)NCC1COc2ccccc2O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I14 compound treatment 1.345788E7 2380000.0 1.34 1.199692E7 -103000.0 -0.06 1.114352E7 -175360.0 -0.102966983423484 0.6799 0.5059 1581992 Maybridge3_004062 COc1ccc(OC(=O)c2cncc(C#Cc3ccccc3)c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I15 compound treatment 1.285428E7 1780000.0 1.0 1.308708E7 987000.0 0.56 1.19694E7 650520.0 0.38196898983032 1.1185 0.9276 2077341 Maybridge3_004063 Clc1ccc(CSc2nc3CSCc3c(=O)[nH]2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I16 compound treatment 1.331992E7 2250000.0 1.26 1.369608E7 1600000.0 0.9 1.24912E7 1172320.0 0.68835683170061 1.6443 0.9703 2077342 Maybridge3_004064 O=C1OCc2ccc(NS(=O)(=O)c3ccccc3)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I17 compound treatment 1.24276E7 1350000.0 0.76 9201400.0 -2900000.0 -1.63 8708400.0 -2610480.0 -1.53280822814403 -1.3882 -0.5872 2077343 Maybridge3_004065 Oc1cc(nc2ccc(Br)cc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I18 compound treatment 1.317968E7 2110000.0 1.18 1.279124E7 691000.0 0.39 1.15824E7 263520.0 0.154732319067955 0.9967 0.7945 2077344 Maybridge3_004066 Cn1c(SCCS(=O)(=O)c2ccc(F)cc2)nnc1C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I19 compound treatment 1.387696E7 2800000.0 1.57 1.391592E7 1820000.0 1.02 1.280836E7 1489480.0 0.874585210250976 2.0039 0.9678 2077345 Maybridge3_004067 CC(C)Oc1cc(nc2ccc(C)cc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I20 compound treatment 1.301504E7 1940000.0 1.09 1.222028E7 120000.0 0.07 1.060932E7 -709560.0 -0.416635793555927 0.4278 0.366 1522065 Maybridge3_004068 O=C(N1CCCCC1)c2ccc(C#Cc3ccccc3)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I21 compound treatment 1.231936E7 1250000.0 0.7 1.257768E7 478000.0 0.27 1.121476E7 -104120.0 -0.0611366464076937 0.5236 0.6966 1485285 Maybridge3_004069 NC(=O)C1CCN(CCS(=O)(=O)c2ccccc2)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I22 compound treatment 1.200832E7 934000.0 0.52 1.19222E7 -178000.0 -0.1 1.114296E7 -175920.0 -0.103295801345001 0.1854 0.3408 2077346 Maybridge3_004070 O=C(Nc1ccccc1)c2ncc[nH]2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I23 mock treatment 1.203816E7 964000.0 0.54 1.0952E7 -1150000.0 -0.65 1.19908E7 671920.0 0.394534531831133 0.1672 0.1796 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 I24 mock treatment 1.06616E7 -413000.0 -0.23 1.221052E7 110000.0 0.06 1.182632E7 507440.0 0.297956010882829 0.074 0.1935 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J01 compound treatment 1.255804E7 1480000.0 0.83 1.27562E7 656000.0 0.37 1.175932E7 440440.0 0.258615295272807 0.8437 0.8904 1583673 Maybridge3_004071 CSc1nn(cc1C(=O)N2CCCC2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J02 compound treatment 1.201168E7 937000.0 0.53 1.243512E7 335000.0 0.19 1.246188E7 1143000.0 0.671140864809777 0.8003 0.9161 1456490 Maybridge3_004072 OC(=O)C1CN(C1)C(c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J03 compound treatment 1.028344E7 -791000.0 -0.44 1.0902E7 -1200000.0 -0.67 1.015688E7 -1162000.0 -0.682297187146947 -1.0398 -0.9835 2077347 Maybridge3_004073 C(#Cc1ccc(cc1)c2ccn[nH]2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J04 compound treatment 1.219716E7 1120000.0 0.63 1.322948E7 1130000.0 0.64 1.22998E7 980920.0 0.575971563525115 1.0637 0.999 1541332 Maybridge3_004074 O=C(N1CCOCC1)c2ccc3ncccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J05 compound treatment 1.264564E7 1570000.0 0.88 1.432536E7 2230000.0 1.25 1.204532E7 726440.0 0.426547305190214 1.479 0.9299 2077348 Maybridge3_004075 CCOC(=O)Cc1c(C(=O)OCC)c(C)cn1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J06 compound treatment 1.319892E7 2120000.0 1.19 1.481036E7 2710000.0 1.53 1.209288E7 774000.0 0.454473341524731 1.8322 0.9209 1477926 Maybridge3_004076 Cn1c(SCC(=O)NCc2ccccc2)nnc1c3ccc4ncccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J07 compound treatment 1.23426E7 1270000.0 0.71 1.385724E7 1760000.0 0.99 1.254668E7 1227800.0 0.720933292925148 1.3985 0.9876 2077349 Maybridge3_004077 C/C(=N\O)/c1ccccc1Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J08 compound treatment 1.266768E7 1590000.0 0.89 1.287156E7 771000.0 0.43 1.245872E7 1139840.0 0.669285392252647 1.1538 0.9624 2077350 Maybridge3_004078 OCCN1CCN(CC1)c2cc(nc3ccccc23)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J09 compound treatment 1.198484E7 910000.0 0.51 1.263364E7 533000.0 0.3 1.225564E7 936760.0 0.550041921714091 0.7862 0.972 2077351 Maybridge3_004079 COc1ccc(/C=N/O)cc1OC2CCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J10 compound treatment 1.338484E7 2310000.0 1.3 1.381768E7 1720000.0 0.97 1.240924E7 1090360.0 0.640231980187216 1.6771 0.9637 2077352 Maybridge3_004080 COC(=O)c1ccc(CSc2nnc(c3ccc4ncccc4c3)n2C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J11 compound treatment 1.35184E7 2440000.0 1.37 1.503828E7 2940000.0 1.65 1.22386E7 919720.0 0.540036462102229 2.0592 0.9292 1118471 Maybridge3_004081 Clc1ccc(cc1)C(=O)n2ncc(C#N)c2C3CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J12 compound treatment 1.399332E7 2920000.0 1.64 1.25584E7 458000.0 0.26 1.360172E7 2282840.0 1.34042625706242 1.8694 0.8763 2077353 Maybridge3_004082 OC1CCN(CC1)c2cc(nc3cc(Cl)cc(Cl)c23)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J13 compound treatment 1.380212E7 2730000.0 1.53 1.447784E7 2380000.0 1.34 1.456012E7 3241240.0 1.90317464274369 2.7561 0.9893 1435746 Maybridge3_004083 CCOC(=O)Cc1cc(=O)n2nc(C)cc2[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J14 compound treatment 1.2878E7 1800000.0 1.01 1.60844E7 3980000.0 2.24 1.333928E7 2020400.0 1.18632808684311 2.5647 0.9388 2077354 Maybridge3_004084 CC(C)n1c(nc2cc(ccc12)C(=O)NCc3ccncc3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J15 compound treatment 1.373408E7 2660000.0 1.49 1.295972E7 860000.0 0.48 1.132032E7 1440.0 8.45531798185545E-4 1.1423 0.7275 1545156 Maybridge3_004085 Clc1ccc(NC(=O)c2ccc3nonc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J16 compound treatment 1.35176E7 2440000.0 1.37 1.237412E7 274000.0 0.15 1.11972E7 -121680.0 -0.0714474369466786 0.8401 0.6075 2077355 Maybridge3_004086 C1CCN(CC1)c2noc(n2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J17 compound treatment 6198400.0 -4880000.0 -2.74 8897080.0 -3200000.0 -1.8 8694360.0 -2624520.0 -1.54105216317634 -3.5119 -0.9693 2077356 Maybridge3_004087 Cn1c(SCc2ccccc2)nnc1c3ccc4nonc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J18 compound treatment 1.221412E7 1140000.0 0.64 9762400.0 -2340000.0 -1.32 1.021704E7 -1101840.0 -0.646972747578306 -0.7637 -0.4773 2077357 Maybridge3_004088 CN(C(=O)c1cc2c(C)cc(C)cc2[nH]1)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J19 compound treatment 1.295804E7 1880000.0 1.06 1.395016E7 1850000.0 1.04 1.308672E7 1767840.0 1.03803120423912 1.8114 1.0 2077358 Maybridge3_004089 FC(F)(F)c1cc(N2CCCC2)c3cccc(Cl)c3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J20 compound treatment 1.261552E7 1540000.0 0.87 1.14286E7 -672000.0 -0.38 1.007524E7 -1243640.0 -0.730234142705188 -0.1401 -0.1173 1547868 Maybridge3_004090 Clc1ccc2c(Nc3ccc4OCOc4c3)ccnc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J21 compound treatment 1.23964E7 1320000.0 0.74 1.29104E7 810000.0 0.46 1.080684E7 -512040.0 -0.300657015238143 0.5185 0.5624 1436487 Maybridge3_004091 O=S(=O)(N1CCc2ccccc12)c3cccc4nsnc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J22 compound treatment 1.167156E7 597000.0 0.34 9112040.0 -2990000.0 -1.68 7883160.0 -3435720.0 -2.01736840948753 -1.9422 -0.7335 1712208 Maybridge3_004092 Cc1cc(Nc2ccc(C)c(F)c2)c3ccccc3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J23 mock treatment 1.298096E7 1910000.0 1.07 1.330456E7 1200000.0 0.68 1.153416E7 215280.0 0.126407003828739 1.0827 0.85 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 J24 mock treatment 1.179488E7 721000.0 0.4 1.233636E7 236000.0 0.13 1.069988E7 -619000.0 -0.363461238247814 0.1006 0.1796 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K01 compound treatment 1.138972E7 315000.0 0.18 1.230556E7 205000.0 0.12 1.160432E7 285440.0 0.16760319199589 0.2658 0.9848 2077359 Maybridge3_004093 N/C(=N/O)/C1COc2ccccc2O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K02 compound treatment 1.123192E7 158000.0 0.09 1.188216E7 -218000.0 -0.12 1.172824E7 409360.0 0.240365900628635 0.119 0.419 2077360 Maybridge3_004094 CS(=O)(=O)NCCSc1cc(nc2ccccc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K03 compound treatment 9211160.0 -1860000.0 -1.05 9862800.0 -2240000.0 -1.26 9721240.0 -1597640.0 -0.938094043092468 -1.873 -0.9925 1286819 Maybridge3_004095 O=C(Sc1cccs1)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K04 compound treatment 8818480.0 -2260000.0 -1.27 1.127624E7 -824000.0 -0.46 1.063236E7 -686520.0 -0.403107284784959 -1.2321 -0.8749 2077361 Maybridge3_004096 COC(=O)c1scc2c(Sc3nccn3C)cc(nc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K05 compound treatment 1.22348E7 1160000.0 0.65 1.280576E7 706000.0 0.4 1.13204E7 1520.0 8.92505786973631E-4 0.6061 0.7941 1368806 Maybridge3_004097 Clc1ccccc1c2nc(no2)c3ccc4nonc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K06 compound treatment 1.198724E7 913000.0 0.51 1.254372E7 444000.0 0.25 1.185476E7 535880.0 0.314655263896993 0.6219 0.9547 1522513 Maybridge3_004098 Cc1[nH]c2ccccc2c1SCc3nnc(SCC(=O)Nc4ccccc4)n3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K07 compound treatment 1.251232E7 1440000.0 0.81 1.288904E7 789000.0 0.44 1.19064E7 587520.0 0.344976973659702 0.9219 0.9367 1339013 Maybridge3_004099 CN(C)C(=O)c1csc(n1)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K08 compound treatment 1.280372E7 1730000.0 0.97 1.290688E7 807000.0 0.45 1.232456E7 1005680.0 0.590510013055027 1.1639 0.9508 2077362 Maybridge3_004100 CCOC(=O)c1ccc(OCC#Cc2ccc(cn2)C(F)(F)F)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K09 compound treatment 7640560.0 -3430000.0 -1.93 8331800.0 -3770000.0 -2.12 7962240.0 -3356640.0 -1.97093462157051 -3.4762 -0.9992 1146145 Maybridge3_004101 O=C(Nc1ccccc1)c2ccc3OCCc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K10 compound treatment 1.26888E7 1610000.0 0.91 1.263864E7 538000.0 0.3 1.132512E7 6240.0 0.0036639711254707 0.7007 0.7328 1555938 Maybridge3_004102 O=S1(=O)CC(N2CCCCC2)c3ccccc31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K11 compound treatment 1.2746E7 1670000.0 0.94 1.280576E7 706000.0 0.4 1.226428E7 945400.0 0.555115112503204 1.0919 0.9406 2077363 Maybridge3_004103 CN(C(=O)c1ccc2OCCc2c1)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K12 compound treatment 1.341504E7 2340000.0 1.31 1.35084E7 1410000.0 0.79 1.22032E7 884320.0 0.519250472063501 1.5165 0.9357 2077364 Maybridge3_004104 CC(C)S(=O)(=O)/C(=C/c1c[nH]cn1)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K13 compound treatment 1.292296E7 1850000.0 1.04 1.293896E7 839000.0 0.47 1.185448E7 535600.0 0.314490854936235 1.0537 0.8905 2077365 Maybridge3_004105 Nc1ccccc1SCc2ccc3nonc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K14 compound treatment 1.289876E7 1820000.0 1.02 1.359504E7 1490000.0 0.84 1.306048E7 1741600.0 1.02262373591663 1.6679 0.996 1460370 Maybridge3_004106 C(#Cc1cncc(c1)c2nc(no2)c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K15 compound treatment 1.309296E7 2020000.0 1.13 1.259724E7 497000.0 0.28 1.142524E7 106360.0 0.0624519180937601 0.8522 0.7287 2077366 Maybridge3_004107 Cn1cc(cc1/C=C(\C#N)/S(=O)(=O)c2cccs2)C(=O)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K16 compound treatment 1.28334E7 1760000.0 0.99 1.286712E7 767000.0 0.43 1.173508E7 416200.0 0.244382176670017 0.9608 0.869 2077367 Maybridge3_004108 Cn1c(SCC(=O)Nc2ccccc2)nnc1c3cncc(C#Cc4ccccc4)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K17 compound treatment 1.22416E7 1170000.0 0.66 1.338172E7 1280000.0 0.72 1.170748E7 388600.0 0.228176150538127 0.9268 0.9257 2077368 Maybridge3_004109 Cc1cc(C)n2nc(c(Cl)c2n1)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K18 compound treatment 1.204716E7 973000.0 0.55 1.204436E7 -55800.0 -0.03 1.072556E7 -593320.0 -0.348382587846839 0.0962 0.1483 2077369 Maybridge3_004110 FC(F)(F)c1ccc(nc1)N2CCC(CC2)n3cccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K19 compound treatment 1.205396E7 980000.0 0.55 1.249396E7 394000.0 0.22 1.130072E7 -18160.0 -0.0106630954548955 0.4395 0.7408 2077370 Maybridge3_004111 Cn1c(Sc2cccs2)nc(C#N)c1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K20 compound treatment 1.16308E7 556000.0 0.31 1.102324E7 -1080000.0 -0.61 1.03504E7 -968480.0 -0.568667108268567 -0.4979 -0.5607 1197251 Maybridge3_004112 O=C(N1CCCC1)c2ccc(C#Cc3ccccc3)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K21 compound treatment 1.199868E7 924000.0 0.52 1.222E7 120000.0 0.07 1.234712E7 1028240.0 0.603756677893267 0.6873 0.86 2077371 Maybridge3_004113 OC(=O)CSc1cc(nc2ccccc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K22 compound treatment 1.153324E7 459000.0 0.26 1.207176E7 -28400.0 -0.02 1.172824E7 409360.0 0.240365900628635 0.2783 0.789 1060162 Maybridge3_004114 O=C1CC2CCCC(C1)N2Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K23 mock treatment 1.16464E7 572000.0 0.32 1.31606E7 1060000.0 0.6 1.147176E7 152880.0 0.089767292574032 0.582 0.8511 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 K24 mock treatment 1.085128E7 -223000.0 -0.13 1.1381E7 -719000.0 -0.4 1.107676E7 -242120.0 -0.142166777067142 -0.3882 -0.8684 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L01 compound treatment 1.194492E7 871000.0 0.49 1.258812E7 488000.0 0.27 1.176744E7 448560.0 0.263383155134797 0.593 0.957 2077372 Maybridge3_004115 COC(=O)c1c(C)[nH]c(C)c1/C=C(\C#N)/S(=O)(=O)c2ccc(C)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L02 compound treatment 1.270904E7 1630000.0 0.92 1.324328E7 1140000.0 0.64 1.179204E7 473160.0 0.277827656687134 1.062 0.9194 2077373 Maybridge3_004116 COC(=O)c1ccccc1NC(=O)/C=N/O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L03 compound treatment 9869240.0 -1210000.0 -0.68 1.240748E7 307000.0 0.17 1.170388E7 385000.0 0.226062321042663 -0.1604 -0.2185 1421413 Maybridge3_004117 COC(=O)C(Cc1csc2ccc(Cl)cc12)NC(=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L04 compound treatment 1.25326E7 1460000.0 0.82 1.279404E7 694000.0 0.39 1.225896E7 940080.0 0.551991342248797 1.0171 0.9576 1389033 Maybridge3_004118 COC(=O)c1sccc1NC(=O)c2ccc3ncccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L05 compound treatment 1.27444E7 1670000.0 0.94 1.315608E7 1060000.0 0.59 1.197792E7 659040.0 0.386971719636251 1.1082 0.9423 2077374 Maybridge3_004119 Cn1c(CSCC(=O)Nc2ccccc2)nnc1SCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L06 compound treatment 1.426964E7 3200000.0 1.79 1.317268E7 1070000.0 0.6 1.2164E7 845120.0 0.496233217557339 1.6712 0.8538 2077375 Maybridge3_004120 COC(=O)c1ccc2n(nnc2c1)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L07 compound treatment 1.236488E7 1290000.0 0.72 1.271356E7 613000.0 0.35 1.25646E7 1245720.0 0.731455466413679 1.0402 0.9577 2077376 Maybridge3_004121 Nc1cc(n[nH]1)c2cccc(c2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L08 compound treatment 1.287112E7 1800000.0 1.01 1.41102E7 2010000.0 1.13 1.29528E7 1633920.0 0.959396747007865 1.7898 0.9976 1207721 Maybridge3_004122 Cn1nnnc1SCC(=O)NC2Cc3ccccc3C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L09 compound treatment 1.15094E7 435000.0 0.24 1.193112E7 -169000.0 -0.1 1.154556E7 226680.0 0.133100797231041 0.163 0.5542 2077377 Maybridge3_004123 C/C(=N\O)/c1ccc(C#Cc2ccccc2)s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L10 compound treatment 1.342888E7 2350000.0 1.32 1.360212E7 1500000.0 0.85 1.271184E7 1392960.0 0.817911092778151 1.7239 0.974 2077378 Maybridge3_004124 CSc1nnc(c2ccc3ncccc3c2)n1CC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L11 compound treatment 1.26846E7 1610000.0 0.9 1.357416E7 1470000.0 0.83 1.246996E7 1151080.0 0.675885237677373 1.3914 0.9931 2077379 Maybridge3_004125 O=C(c1cccs1)n2ncc(C#N)c2C3CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L12 compound treatment 1.322964E7 2160000.0 1.21 1.346872E7 1370000.0 0.77 1.208092E7 762040.0 0.447450730200912 1.402 0.9328 2077380 Maybridge3_004126 FC(F)(F)c1cc(N2CCC(=O)CC2)c3c(Cl)cc(Cl)cc3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L13 compound treatment 1.312092E7 2050000.0 1.15 1.366452E7 1560000.0 0.88 1.399968E7 2680800.0 1.57409836428876 2.0809 0.9729 1174104 Maybridge3_004127 CCOC(=O)Cc1cc(=O)n2nc(cc2[nH]1)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L14 compound treatment 1.306388E7 1990000.0 1.12 1.349148E7 1390000.0 0.78 1.245612E7 1137240.0 0.667758737617034 1.4829 0.9761 2077381 Maybridge3_004128 CC(C)n1c(nc2cc(ccc12)C(=O)N3CCCCC3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L15 compound treatment 1.304212E7 1970000.0 1.11 1.31114E7 1010000.0 0.57 1.21638E7 844920.0 0.496115782585369 1.2532 0.9362 1556737 Maybridge3_004129 Clc1ccc(OC(=O)c2ccc3nonc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L16 compound treatment 1.27174E7 1640000.0 0.92 1.355136E7 1450000.0 0.82 1.236E7 1041120.0 0.611319490088149 1.3574 0.9867 1225885 Maybridge3_004130 COc1ccc2c(CC(=O)O)coc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L17 compound treatment 1.255076E7 1480000.0 0.83 1.279956E7 699000.0 0.39 1.247004E7 1151160.0 0.675932211666161 1.0963 0.9617 1128713 Maybridge3_004131 CSc1nc(N)nc(n1)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L18 compound treatment 1.353436E7 2460000.0 1.38 1.3714E7 1610000.0 0.91 1.259044E7 1271560.0 0.74662806479223 1.7533 0.9663 1364620 Maybridge3_004132 O=C(NCc1ccc(s1)S(=O)(=O)NCCc2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L19 compound treatment 1.22668E7 1190000.0 0.67 1.182552E7 -275000.0 -0.15 1.123712E7 -81760.0 -0.0480074165414237 0.2697 0.3914 1329219 Maybridge3_004133 Clc1ccc(cc1)S(=O)(=O)CCN2CCN(Cc3ccccc3)CC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L20 compound treatment 7533240.0 -3540000.0 -1.99 8381560.0 -3720000.0 -2.09 7119400.0 -4199480.0 -2.46582908044738 -3.7805 -0.9956 1549522 Maybridge3_004134 Cc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L21 compound treatment 1.231468E7 1240000.0 0.7 1.274056E7 640000.0 0.36 1.087368E7 -445200.0 -0.261410247605698 0.4594 0.5556 1288040 Maybridge3_004135 N#CC1(CCN(Cc2ccccc2)CC1)NCCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L22 compound treatment 1.236036E7 1290000.0 0.72 1.211948E7 19300.0 0.01 1.089052E7 -428360.0 -0.251522222965806 0.2781 0.3635 1682067 Maybridge3_004136 O=C(NCc1ccc(s1)S(=O)(=O)NC2CCCCC2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L23 mock treatment 1.189416E7 820000.0 0.46 1.259944E7 499000.0 0.28 1.125584E7 -63040.0 -0.0370155031650116 0.4067 0.7522 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 L24 mock treatment 1.069556E7 -379000.0 -0.21 1.14818E7 -618000.0 -0.35 1.199972E7 680840.0 0.399772131581005 -0.093 -0.1628 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M01 compound treatment 620560.0 -1.05E7 -5.87 556040.0 -1.15E7 -6.5 876280.0 -1.04426E7 -6.13163219148082 -10.6819 -0.9991 2077382 Maybridge3_004137 CSC(=C(C#N)C(=O)c1ccoc1C)SC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M02 compound treatment 1.090332E7 -171000.0 -0.1 1.181064E7 -290000.0 -0.16 1.19398E7 620920.0 0.364588613978728 0.0609 0.1483 2077383 Maybridge3_004138 O=C(OCC#Cc1ccc(s1)c2ccccn2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M03 compound treatment 1.18E7 726000.0 0.41 1.243404E7 334000.0 0.19 1.15314E7 212520.0 0.12478640121555 0.4159 0.8927 1134608 Maybridge3_004139 O=C(Nc1cc(n[nH]1)c2ccccc2)C3COc4ccccc4O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M04 compound treatment 1.16634E7 589000.0 0.33 1.230276E7 203000.0 0.11 1.171736E7 398480.0 0.233977438153456 0.3919 0.9311 2077384 Maybridge3_004140 FC(F)(F)c1ccc(Oc2ccc(Br)cc2)nc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M05 compound treatment 1.244772E7 1370000.0 0.77 1.217792E7 77700.0 0.04 1.233036E7 1011480.0 0.593915627242163 0.8135 0.8348 1601097 Maybridge3_004141 COc1ccc(NS(=O)(=O)c2cn(C)cn2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M06 compound treatment 1.229228E7 1220000.0 0.68 1.283016E7 730000.0 0.41 1.221556E7 896680.0 0.52650795333126 0.9362 0.9792 1644493 Maybridge3_004142 Clc1ccc(Cn2ccnc2COC(=O)c3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M07 compound treatment 1.231212E7 1240000.0 0.7 1.285604E7 756000.0 0.43 1.181396E7 495080.0 0.290698529615069 0.8149 0.9416 1286518 Maybridge3_004143 O=C(NCc1ccco1)c2csc(n2)C3COc4ccccc4O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M08 compound treatment 1.269916E7 1620000.0 0.91 1.380488E7 1700000.0 0.96 1.28266E7 1507720.0 0.88529527969466 1.592 0.9994 2077385 Maybridge3_004144 CC(C)(O)C#Cc1ccc(CO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M09 compound treatment 1.322676E7 2150000.0 1.21 1.328104E7 1180000.0 0.66 1.24266E7 1107720.0 0.650425335754231 1.4573 0.9554 2077386 Maybridge3_004145 CNC(=O)c1ccc2OCCc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M10 compound treatment 1.325812E7 2180000.0 1.23 1.35798E7 1480000.0 0.83 1.272944E7 1410560.0 0.82824537031153 1.6672 0.9817 1677679 Maybridge3_004146 Clc1ccc(s1)S(=O)(=O)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M11 compound treatment 375680.0 -1.07E7 -6.01 485360.0 -1.16E7 -6.54 445160.0 -1.087372E7 -6.38477501705981 -10.9305 -0.9994 1430746 Maybridge3_004147 CN(C)CC1COc2ccccc2C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M12 compound treatment 1.382068E7 2750000.0 1.54 1.346904E7 1370000.0 0.77 1.266508E7 1346200.0 0.790454796331515 1.7918 0.9446 2077387 Maybridge3_004148 Clc1ccc(cc1)S(=O)(=O)/C(=C/c2c[nH]cn2)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M13 compound treatment 1.25518E7 1480000.0 0.83 1.302576E7 926000.0 0.52 1.281036E7 1491480.0 0.875759559970678 1.2855 0.9782 1167106 Maybridge3_004149 Brc1cc2CCOc2c(c1)C(=O)Nc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M14 compound treatment 1.221792E7 1140000.0 0.64 1.326316E7 1160000.0 0.65 1.222924E7 910360.0 0.534540505414023 1.0574 0.9961 2077388 Maybridge3_004150 CN(C)CC#Cc1cncc(C#N)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M15 compound treatment 1.28702E7 1800000.0 1.01 1.296996E7 870000.0 0.49 1.19916E7 672720.0 0.395004271719014 1.0931 0.9195 1276171 Maybridge3_004151 N#Cc1ccc(OCc2ccc3nonc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M16 compound treatment 1.206788E7 994000.0 0.56 1.073096E7 -1370000.0 -0.77 1.062192E7 -696960.0 -0.409237390321804 -0.3591 -0.3467 2077389 Maybridge3_004152 O=C(Sc1cccs1)c2cncc(C#Cc3ccccc3)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M17 compound treatment 1.2606E7 1530000.0 0.86 9686680.0 -2410000.0 -1.36 8062480.0 -3256400.0 -1.91207621361903 -1.3916 -0.557 2077390 Maybridge3_004153 O=C(Sc1ccccc1)c2ccc3ncsc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M18 compound treatment 1.237036E7 1300000.0 0.73 1.206088E7 -39300.0 -0.02 1.112984E7 -189040.0 -0.110999535506247 0.3434 0.4662 2077391 Maybridge3_004154 Fc1ccc(cc1)S(=O)(=O)CCSc2cccs2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M19 compound treatment 1.275572E7 1680000.0 0.94 1.3018E7 918000.0 0.52 1.184116E7 522280.0 0.306669685803018 1.0206 0.9118 2077392 Maybridge3_004155 Cn1c(CC2Sc3ccccc3NC2=O)nnc1SCC(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M20 compound treatment 1.293864E7 1860000.0 1.05 1.346936E7 1370000.0 0.77 1.208044E7 761560.0 0.447168886268183 1.3077 0.9511 2077393 Maybridge3_004156 COC(=O)CSCC1=CS(=O)(=O)c2ccc(Cl)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M21 compound treatment 1.187832E7 804000.0 0.45 1.204E7 -60200.0 -0.03 1.058304E7 -735840.0 -0.432066748872814 -0.0083 -0.0133 1387055 Maybridge3_004157 Cc1ncn2cc([nH]c(=O)c12)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M22 compound treatment 1.208152E7 1010000.0 0.57 1.237124E7 271000.0 0.15 1.158548E7 266600.0 0.156540817636296 0.5051 0.8328 1682804 Maybridge3_004158 ON=C1CC2CCCC(C1)N2Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M23 mock treatment 1.1311E7 237000.0 0.13 1.248112E7 381000.0 0.21 1.1271E7 -47880.0 -0.0281139322896694 0.1843 0.7261 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 M24 mock treatment 1.031408E7 -760000.0 -0.43 1.179656E7 -304000.0 -0.17 1.076448E7 -554400.0 -0.325529742301435 -0.5332 -0.9462 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N01 compound treatment 1.589016E7 4820000.0 2.7 1.313096E7 1030000.0 0.58 1.31204E7 1801520.0 1.05780725351891 2.5074 0.8466 2077394 Maybridge3_004159 CS(=O)(=O)N1CCN(CC1)c2cc(nc3ccccc23)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N02 compound treatment 1.163724E7 563000.0 0.32 1.3327E7 1230000.0 0.69 1.378636E7 2467480.0 1.44884222318533 1.4177 0.8667 1276474 Maybridge3_004160 O=C(Nc1ccccc1)c2ccc3ncccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N03 compound treatment 1.270604E7 1630000.0 0.92 1.424404E7 2140000.0 1.21 1.339984E7 2080960.0 1.22188739635569 1.9313 0.9921 2077395 Maybridge3_004161 CC(=O)n1ccc(n1)c2ccc(C#Cc3ccccc3)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N04 compound treatment 1.2928E7 1850000.0 1.04 1.469132E7 2590000.0 1.46 1.496584E7 3646960.0 2.14140322688247 2.6796 0.9596 1515408 Maybridge3_004162 Clc1ccc(cc1)C(=O)N2CCC(CC2)n3nnc4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N05 compound treatment 1.173288E7 659000.0 0.37 1.273216E7 632000.0 0.36 1.219064E7 871760.0 0.511875555823771 0.7145 0.9857 2077396 Maybridge3_004163 c1ccc(cc1)c2cc3ccccc3nn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N06 compound treatment 1.318392E7 2110000.0 1.18 1.378488E7 1680000.0 0.95 1.740516E7 6086280.0 3.57371060601439 3.2949 0.8486 1203539 Maybridge3_004164 COc1ccc(cc1OC)C(=O)NC2Cc3ccccc3C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N07 compound treatment 1.356948E7 2500000.0 1.4 1.367128E7 1570000.0 0.88 1.350016E7 2181280.0 1.28079277829595 2.0592 0.9832 1329343 Maybridge3_004165 CC(=O)NC(=O)c1cnn(c1N)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N08 compound treatment 1.356468E7 2490000.0 1.4 1.409312E7 1990000.0 1.12 1.309348E7 1774600.0 1.04200050629171 2.0569 0.9918 1485969 Maybridge3_004166 Cn1ccnc1SCC(=O)NC2Cc3ccccc3C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N09 compound treatment 1.314148E7 2070000.0 1.16 1.40876E7 1990000.0 1.12 1.450264E7 3183760.0 1.86942383179945 2.3956 0.9704 2077397 Maybridge3_004167 COc1ccc(cc1OC)S(=O)(=O)N(CCC#N)C2CCc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N10 compound treatment 1.571024E7 4640000.0 2.6 1.4439E7 2340000.0 1.32 1.33306E7 2011720.0 1.1812314090596 2.9454 0.9357 2077398 Maybridge3_004168 Cn1c(SCC#N)nnc1c2ccc3ncccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N11 compound treatment 1.593124E7 4860000.0 2.73 1.426568E7 2170000.0 1.22 1.30812E7 1762320.0 1.03478999901274 2.8762 0.9096 1461212 Maybridge3_004169 CSc1sc(C(=O)O)c(C)c1C(C)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N12 compound treatment 1.58766E7 4800000.0 2.7 1.713544E7 5040000.0 2.83 1.410432E7 2785440.0 1.63554034162357 4.138 0.9758 2077399 Maybridge3_004170 Fc1ccc2nc(cc(N3CCOCC3)c2c1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N13 compound treatment 1.552628E7 4450000.0 2.5 1.583608E7 3740000.0 2.1 1.364756E7 2328680.0 1.367342352638 3.4473 0.9733 2077400 Maybridge3_004171 FC(F)(F)c1cc(nc2cc(nn12)c3ccccc3)c4ccccn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N14 compound treatment 1.345072E7 2380000.0 1.33 1.487276E7 2770000.0 1.56 1.321608E7 1897200.0 1.11398814410946 2.3149 0.9908 2077401 Maybridge3_004172 CC(C)n1c(nc2cc(ccc12)C(=O)N3CCC(O)CC3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N15 compound treatment 1.456312E7 3490000.0 1.96 1.308632E7 986000.0 0.56 1.280848E7 1489600.0 0.874655671234158 1.9568 0.8828 1710980 Maybridge3_004173 COc1ccc(OC(=O)c2ccc3nonc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N16 compound treatment 1.465764E7 3580000.0 2.01 1.371956E7 1620000.0 0.91 1.271E7 1391120.0 0.816830691036025 2.1599 0.9169 2077402 Maybridge3_004174 CCc1ccc2[nH]c(cc2c1)C(=O)NCCN3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N17 compound treatment 1.368904E7 2610000.0 1.47 1.293644E7 836000.0 0.47 1.210404E7 785160.0 0.461026212960668 1.3859 0.861 1579669 Maybridge3_004175 Nc1nc(ncc1C#N)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N18 compound treatment 1.353812E7 2460000.0 1.38 1.012636E7 -1970000.0 -1.11 1.031684E7 -1002040.0 -0.588372696565169 -0.1822 -0.0975 1418287 Maybridge3_004176 Clc1ccc2c(Nc3ccccc3)ccnc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N19 compound treatment 1.35638E7 2490000.0 1.4 1.411508E7 2010000.0 1.13 1.214664E7 827760.0 0.486039861990324 1.7427 0.9345 1622980 Maybridge3_004177 Brc1ccc(s1)S(=O)(=O)N2CCN(CC2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N20 compound treatment 1.262468E7 1550000.0 0.87 1.21654E7 65200.0 0.04 1.107108E7 -247800.0 -0.145501930271096 0.4399 0.4979 1739946 Maybridge3_004178 Clc1ccc2c(ccnc2c1)N3CCN(CC3)C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N21 compound treatment 1.453464E7 3460000.0 1.94 1.08714E7 -1230000.0 -0.69 1.167492E7 356040.0 0.209057737101376 0.8435 0.4068 2077403 Maybridge3_004179 Cc1cc(Nc2cc(nc3c(Cl)cccc23)C(F)(F)F)on1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N22 compound treatment 1.263144E7 1560000.0 0.87 1.070192E7 -1400000.0 -0.79 1.055132E7 -767560.0 -0.45069193542729 -0.2097 -0.1664 1374568 Maybridge3_004180 CCC(=O)N1CCN(CC1)c2ccnc3cc(Cl)ccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N23 mock treatment 1.539448E7 4320000.0 2.43 1.354044E7 1440000.0 0.81 1.169648E7 377600.0 0.221717227079765 1.997 0.7777 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 N24 mock treatment 1.125008E7 176000.0 0.1 1.446972E7 2370000.0 1.33 1.404744E7 2728560.0 1.60214183559524 1.7521 0.8395 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O01 compound treatment 1.12212E7 147000.0 0.08 1.244788E7 348000.0 0.2 1.065192E7 -666960.0 -0.391622144526272 -0.0655 -0.147 2077404 Maybridge3_004181 O=S(=O)(Nc1cccc2nsnc12)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O02 compound treatment 1.446728E7 3390000.0 1.91 1.555672E7 3460000.0 1.95 1.678684E7 5467960.0 3.21064864667127 4.0773 0.9684 2077405 Maybridge3_004182 Clc1cccc(NC(=O)OCC#Cc2ccc(s2)c3ccccn3)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O03 compound treatment 1.542388E7 4350000.0 2.44 1.501008E7 2910000.0 1.64 1.367776E7 2358880.0 1.3850750334055 3.1559 0.9707 1586200 Maybridge3_004183 CC(C)(C)c1cc(NC(=O)C2COc3ccccc3O2)[nH]n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O04 compound treatment 1.31506E7 2080000.0 1.17 1.313872E7 1040000.0 0.58 1.235428E7 1035400.0 0.607960849889801 1.3618 0.9462 2077406 Maybridge3_004184 COC(=O)c1scc2c(cc(nc12)C(F)(F)F)N3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O05 compound treatment 1.092944E7 -145000.0 -0.08 1.260576E7 506000.0 0.28 1.174736E7 428480.0 0.251592683948988 0.2626 0.6759 1200852 Maybridge3_004185 OC(=O)c1csc(n1)C2COc3ccccc3O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O06 compound treatment 1.246268E7 1390000.0 0.78 1.296536E7 865000.0 0.49 1.233252E7 1013640.0 0.595183924939442 1.075 0.9816 1252194 Maybridge3_004186 Clc1ccc(Cn2ccnc2COC(=O)Nc3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O07 compound treatment 1.355052E7 2480000.0 1.39 1.457668E7 2480000.0 1.39 1.457884E7 3259960.0 1.9141665561201 2.713 0.9879 1603073 Maybridge3_004187 O=C(SCc1ccco1)c2csc(n2)C3COc4ccccc4O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O08 compound treatment 1.3829E7 2750000.0 1.55 1.471792E7 2620000.0 1.47 1.113428E7 -184600.0 -0.108392479128508 1.6815 0.786 1365631 Maybridge3_004188 O=S1(=O)CC(Sc2ccccc2)c3ccccc31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O09 compound treatment 1.360092E7 2530000.0 1.42 1.382952E7 1730000.0 0.97 1.309888E7 1780000.0 1.04517125053491 1.9848 0.9858 1337081 Maybridge3_004189 CC(C)(C)NC(=O)c1ccc2OCCc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O10 compound treatment 1.27726E7 1700000.0 0.95 1.531432E7 3210000.0 1.81 1.346304E7 2144160.0 1.25899684749828 2.3222 0.9669 1676570 Maybridge3_004190 CC(C)(C)OC(=O)N1CCN(CCNC(=O)c2ccccc2)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O11 compound treatment 1.36686E7 2590000.0 1.46 1.412916E7 2030000.0 1.14 1.299476E7 1675880.0 0.984034604127216 2.0688 0.9867 2077407 Maybridge3_004191 CSc1ncc(c2nnc(SCc3ccccc3)n2C)n1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O12 compound treatment 1.59548E7 4880000.0 2.74 1.353468E7 1430000.0 0.81 1.285428E7 1535400.0 0.901548279815338 2.5694 0.8574 2077408 Maybridge3_004192 CCOC(=O)c1cncc(C#CCOC(=O)Nc2ccccc2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O13 compound treatment 1.438268E7 3310000.0 1.86 1.974888E7 7650000.0 4.31 1.209488E7 776000.0 0.455647691244433 3.8217 0.8111 2077409 Maybridge3_004193 CN(C)C(=O)c1cc(Br)cc2CCOc21 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O14 compound treatment 1.358724E7 2510000.0 1.41 1.361692E7 1520000.0 0.85 1.165892E7 340040.0 0.199662939343759 1.4231 0.8565 2077410 Maybridge3_004194 C/S(=N\S(=O)(=O)c1cccc2nsnc12)/c3ccc(cn3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O15 compound treatment 1.155792E7 484000.0 0.27 1.10404E7 -1060000.0 -0.6 1.123824E7 -80640.0 -0.0473497806983905 -0.2149 -0.3271 1347374 Maybridge3_004195 Cc1c(ncn1Cc2ccc(Cl)cc2)C(=O)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O16 compound treatment 1.2481E7 1410000.0 0.79 1.3627E7 1530000.0 0.86 1.346564E7 2146760.0 1.26052350213389 1.6801 0.9779 2077411 Maybridge3_004196 Clc1ccc(cc1)S(=O)(=O)/C(=C/NC2CCN(Cc3ccccc3)CC2)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O17 compound treatment 1.235308E7 1280000.0 0.72 1.283096E7 731000.0 0.41 1.22376E7 918720.0 0.539449287242378 0.9636 0.9754 2077412 Maybridge3_004197 CN(C)C(=O)c1ccc2ncsc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O18 compound treatment 1.30974E7 2020000.0 1.14 1.33002E7 1200000.0 0.68 1.184124E7 522360.0 0.306716659791807 1.2231 0.9013 1389063 Maybridge3_004198 NC(=O)C1CCN(CCO)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O19 compound treatment 1.2677E7 1600000.0 0.9 1.268004E7 580000.0 0.33 1.100308E7 -315800.0 -0.185429820740969 0.6011 0.6163 2077413 Maybridge3_004199 CN(C)CCOc1cc(nc2ccc(C)cc12)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O20 compound treatment 1.28954E7 1820000.0 1.02 1.216376E7 63600.0 0.04 1.602664E7 4707760.0 2.76427831821249 2.2072 0.7488 2077414 Maybridge3_004200 Clc1ccc2c(c1)C(=CS2(=O)=O)CSc3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O21 compound treatment 1.320208E7 2130000.0 1.2 1.236444E7 264000.0 0.15 1.163392E7 315040.0 0.184983567847482 0.8827 0.7244 2077415 Maybridge3_004201 CC(C)NC(=O)CSc1nnc(CSc2cc(nc3ccccc23)C(F)(F)F)n1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O22 compound treatment 1.12272E7 153000.0 0.09 1.134492E7 -755000.0 -0.43 1.104836E7 -270520.0 -0.158842543086912 -0.2876 -0.6226 2077416 Maybridge3_004202 CSc1nn(cc1C(=O)Nc2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O23 mock treatment 1.16506E7 576000.0 0.32 1.268072E7 581000.0 0.33 1.170444E7 385560.0 0.22639113896418 0.5062 0.9875 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 O24 mock treatment 9120040.0 -1950000.0 -1.1 1.022312E7 -1880000.0 -1.06 1.052348E7 -795400.0 -0.467038883525544 -1.5134 -0.9497 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P01 compound treatment 7959640.0 -3110000.0 -1.75 8857480.0 -3240000.0 -1.83 7686440.0 -3632440.0 -2.13287744791743 -3.2953 -0.9962 1584127 Maybridge3_004203 CCOC(=O)C1=C(NC2CCN(Cc3ccccc3)CC2)C(=O)N(C1)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P02 compound treatment 1.061276E7 -462000.0 -0.26 1.186612E7 -234000.0 -0.13 1.138932E7 70440.0 0.0413605971279096 -0.2019 -0.6872 1515716 Maybridge3_004204 COc1ccc(NC(=O)c2ccc3ncccc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P03 compound treatment 1.21868E7 1110000.0 0.62 1.23102E7 210000.0 0.12 1.100872E7 -310160.0 -0.182118154531409 0.3239 0.4896 2077417 Maybridge3_004205 FC(F)(F)Oc1ccc(CC2SC(=N)NC2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P04 compound treatment 1.17092E7 635000.0 0.36 1.231616E7 216000.0 0.12 1.192272E7 603840.0 0.354559667372472 0.4808 0.9293 2077418 Maybridge3_004206 COc1ccc(cc1)c2cc(n3nccc3n2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P05 compound treatment 1.178884E7 714000.0 0.4 1.183708E7 -263000.0 -0.15 1.158816E7 269280.0 0.158114446260697 0.2375 0.5207 1126864 Maybridge3_004207 OC(=O)c1c(nnc2ccccc12)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P06 compound treatment 1.204436E7 970000.0 0.54 1.1849E7 -251000.0 -0.14 1.195044E7 631560.0 0.370836154487544 0.447 0.6632 1447911 Maybridge3_004208 O=C(NC1Cc2ccccc2C1)c3ccc4nonc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P07 compound treatment 1.189268E7 818000.0 0.46 1.201888E7 -81300.0 -0.05 1.199048E7 671600.0 0.394346635875981 0.4666 0.7683 2077419 Maybridge3_004209 CCCN(Cc1ccco1)S(=O)(=O)c2ccc(OC)c(OC)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P08 compound treatment 1.074496E7 -329000.0 -0.19 1.08986E7 -1200000.0 -0.68 1.17504E7 431520.0 0.253377695522935 -0.351 -0.4708 1328406 Maybridge3_004210 O=C(CSC1=NCCS1)NC2Cc3ccccc3C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P09 compound treatment 1.177072E7 696000.0 0.39 1.11664E7 -934000.0 -0.53 1.073068E7 -588200.0 -0.345376252564401 -0.2771 -0.3741 2077420 Maybridge3_004211 COc1ccc(cc1OC2CCCC2)S(=O)(=O)NCc3ccco3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P10 compound treatment 1.24442E7 1370000.0 0.77 1.276824E7 668000.0 0.38 1.19194E7 600520.0 0.352610246837766 0.8649 0.9339 2077421 Maybridge3_004212 C=CCn1c(SCC#N)nnc1c2ccc3ncccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P11 compound treatment 1.26654E7 1590000.0 0.89 1.325084E7 1150000.0 0.65 1.231688E7 998000.0 0.586000510131371 1.2282 0.9829 1510724 Maybridge3_004213 OC(=O)CCN(Cc1ccco1)S(=O)(=O)c2ccc(Cl)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P12 compound treatment 1.172528E7 651000.0 0.37 1.291984E7 820000.0 0.46 1.17154E7 396520.0 0.232826575428147 0.6119 0.9666 2077422 Maybridge3_004214 CCOC(=O)c1ccc2nc(cc(N3CCN(C)CC3)c2c1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P13 compound treatment 1.282336E7 1750000.0 0.98 1.3663E7 1560000.0 0.88 1.258412E7 1265240.0 0.742917119677972 1.504 0.9937 2077423 Maybridge3_004215 FC(F)(F)c1cc(nc2cc(nn12)C3CC3)c4ccccn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P14 compound treatment 1.19366E7 862000.0 0.48 1.28422E7 742000.0 0.42 1.183536E7 516480.0 0.303264071615882 0.6959 0.9831 1372489 Maybridge3_004216 CN1CCN(CC1)S(=O)(=O)c2ccc(CNC(=O)c3ccccc3)s2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P15 compound treatment 1.219452E7 1120000.0 0.63 1.38678E7 1770000.0 1.0 1.154224E7 223360.0 0.131151376696336 1.0134 0.8556 2077424 Maybridge3_004217 FC(F)(F)c1cccc(OC(=O)c2ccc3nonc3c2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P16 compound treatment 1.151708E7 443000.0 0.25 1.2281E7 181000.0 0.1 1.161912E7 300240.0 0.176293379921686 0.3041 0.9463 1348162 Maybridge3_004218 Cc1cc(C)c2cc([nH]c2c1)C(=O)NCCN3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P17 compound treatment 1.160676E7 532000.0 0.3 1.22748E7 175000.0 0.1 1.12374E7 -81480.0 -0.0478430075806654 0.2018 0.6337 2077425 Maybridge3_004219 FC(F)(F)c1cc(no1)c2ccc(s2)S(=O)(=O)N3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P18 compound treatment 1.105116E7 -23200.0 -0.01 1.184448E7 -256000.0 -0.14 1.113672E7 -182160.0 -0.106959772470471 -0.1524 -0.8475 1553305 Maybridge3_004220 Clc1ccc2c(ccnc2c1)N3CCN(CC3)S(=O)(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P19 compound treatment 1.078388E7 -290000.0 -0.16 1.16766E7 -424000.0 -0.24 1.119112E7 -127760.0 -0.0750174600945731 -0.2752 -0.9219 2077426 Maybridge3_004221 CCOC(=O)C1CCN(CC1)c2cc(nc3ccccc23)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P20 compound treatment 1.01148E7 -960000.0 -0.54 1.018528E7 -1910000.0 -1.08 1.015364E7 -1165240.0 -0.684199633692864 -1.3285 -0.9587 1155426 Maybridge3_004222 CC(=O)N1CCN(CC1)c2ccnc3cc(Cl)ccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P21 compound treatment 1.188324E7 809000.0 0.45 1.227764E7 177000.0 0.1 1.129168E7 -27200.0 -0.0159711561879492 0.3108 0.6676 1324782 Maybridge3_004223 COc1ccc(cc1OC(C)C)C(=O)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P22 compound treatment 1.08944E7 -180000.0 -0.1 1.18906E7 -210000.0 -0.12 1.08586E7 -460280.0 -0.270264844492252 -0.2825 -0.9062 2077427 Maybridge3_004224 FC(F)(F)c1cc(N2CCN(CC2)C(=O)Cc3ccccc3)c4ccccc4n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P23 mock treatment 1.02326E7 -842000.0 -0.47 1.098708E7 -1110000.0 -0.63 1.022432E7 -1094560.0 -0.642698114598591 -1.0058 -0.9914 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1442 P24 mock treatment 6182360.0 -4890000.0 -2.75 9150280.0 -2950000.0 -1.66 7998240.0 -3320640.0 -1.94979632661587 -3.6708 -0.9773 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A01 compound treatment 8784960.0 -2570000.0 -1.44 9331640.0 -1550000.0 -0.87 8403840.0 -1896206.5306122 -1.11340480386091 -1.9795 -0.9795 1965040 CMLD1_000001 CCCC=C(CCC)[C@@H](NC(=O)c1ccccc1)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A02 compound treatment 9918400.0 -1440000.0 -0.81 1.041168E7 -467000.0 -0.26 1.025712E7 -42926.5306122005 -0.0252053795961116 -0.6326 -0.7445 1965041 CMLD1_000002 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(O)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A03 compound treatment 1.055068E7 -805000.0 -0.45 1.102328E7 144000.0 0.08 1.07562E7 456153.4693878 0.267841849458362 -0.0596 -0.1121 1965042 CMLD1_000003 CCCC=C(CCC)[C@@H](NC(=O)c1cccs1)c2ccc(cc2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A04 compound treatment 1.108976E7 -266000.0 -0.15 1.053252E7 -346000.0 -0.19 1.060576E7 305713.4693878 0.179507263542366 -0.0953 -0.3131 1965043 CMLD1_000004 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@H]3[C@H](CC(=O)C(=O)N4CCCC4)C(=O)C=C3CN1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A05 compound treatment 1.039168E7 -964000.0 -0.54 1.110688E7 228000.0 0.13 8429520.0 -1870526.5306122 -1.09832615345993 -0.8728 -0.7088 1965044 CMLD1_000005 CCCC=C(CCC)[C@@H](NC(=O)c1ccc(cc1)C(F)(F)F)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A06 compound treatment 1.184272E7 487000.0 0.27 1.130444E7 426000.0 0.24 1.089672E7 596673.4693878 0.350351660764635 0.4984 0.9873 1965045 CMLD1_000006 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7c[nH]c8ccc(OC)cc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A07 compound treatment 1.12624E7 -93800.0 -0.05 1.160324E7 724000.0 0.41 1.106452E7 764473.4693878 0.448879602247645 0.4642 0.7626 1965046 CMLD1_000007 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1ccc(cc1)c2ccccc2)c3ccc(cc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A08 compound treatment 240440.0 -1.11E7 -6.24 363560.0 -1.05E7 -5.92 375200.0 -9924846.5306122 -5.82762037065563 -10.3867 -0.9996 1965047 CMLD1_000008 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cc(F)c(F)c(F)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A09 compound treatment 1.109808E7 -258000.0 -0.14 1.099104E7 112000.0 0.06 1.051576E7 215713.4693878 0.12666152615577 0.0259 0.1279 1965048 CMLD1_000009 CCCCC=C[C@@H](NC(=O)Oc1cccc(c1)C(F)(F)F)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A10 compound treatment 1.13818E7 25600.0 0.01 1.226092E7 1380000.0 0.78 1.174508E7 1445033.4693878 0.848487324867891 0.9474 0.8229 1965049 CMLD1_000010 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6c[nH]c7ccc(OC)cc67 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A11 compound treatment 1.085468E7 -501000.0 -0.28 1.092424E7 45400.0 0.03 1.023628E7 -63766.5306122005 -0.037442103675408 -0.1695 -0.594 1965050 CMLD1_000011 C[C@]1(C[C@H]1C2CCCCC2)[C@@H](NC(=O)c3cccs3)c4ccc(cc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A12 compound treatment 8501680.0 -2850000.0 -1.6 8298480.0 -2580000.0 -1.45 8387960.0 -1912086.5306122 -1.12272914063534 -2.4125 -0.9898 1965051 CMLD1_000012 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(C)o6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A13 compound treatment 1.07898E7 -566000.0 -0.32 1.109272E7 214000.0 0.12 1.004328E7 -256766.530612201 -0.150766851626665 -0.2012 -0.5407 1965052 CMLD1_000013 CCCC=C(CCC)[C@@H](NC(=O)OCC(C)C)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A14 compound treatment 1.133016E7 -26000.0 -0.01 1.143692E7 558000.0 0.31 1.105268E7 752633.4693878 0.441927451907008 0.4281 0.7892 1965053 CMLD1_000014 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6ccc(OC)c(Br)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A15 compound treatment 1.068016E7 -676000.0 -0.38 1.157604E7 697000.0 0.39 1.133092E7 1030873.4693878 0.605302984911971 0.3569 0.4377 1965054 CMLD1_000015 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccco2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A16 compound treatment 1.161724E7 261000.0 0.15 1.13706E7 492000.0 0.28 1.10978E7 797753.4693878 0.468420781583488 0.5149 0.9138 1965055 CMLD1_000016 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cccc7ccccc67 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A17 compound treatment 1.108908E7 -267000.0 -0.15 1.109484E7 216000.0 0.12 1.036296E7 62913.4693877995 0.0369412075705259 0.0049 0.0251 1965056 CMLD1_000017 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)C(C)(C)C)c2ccc(cc2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A18 compound treatment 1.146996E7 114000.0 0.06 1.150752E7 629000.0 0.35 1.138236E7 1082313.4693878 0.63550725970271 0.6081 0.8328 1965057 CMLD1_000018 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(C)c(F)c6F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A19 compound treatment 9693000.0 -1660000.0 -0.93 1.031052E7 -568000.0 -0.32 9408600.0 -891446.530612201 -0.523434991676944 -1.0262 -0.9183 1965058 CMLD1_000019 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2cccs2)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A20 compound treatment 9283680.0 -2070000.0 -1.16 9490440.0 -1390000.0 -0.78 9318800.0 -981246.530612201 -0.576163294091571 -1.4559 -0.9605 1965059 CMLD1_000020 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(OC)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A21 compound treatment 9894160.0 -1460000.0 -0.82 9937320.0 -941000.0 -0.53 9423880.0 -876166.530612201 -0.51446295981842 -1.0771 -0.9752 1965060 CMLD1_000021 C[C@]1(C[C@H]1C2CCCCC2)[C@@H](NC(=O)Cc3ccccc3)c4ccc(cc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A22 mock treatment 9825920.0 -1530000.0 -0.86 9847800.0 -1030000.0 -0.58 8714080.0 -1585966.5306122 -0.931239675340711 -1.369 -0.9822 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A23 mock treatment 9488680.0 -1870000.0 -1.05 1.039688E7 -482000.0 -0.27 9434320.0 -865726.530612201 -0.508332854281574 -1.0557 -0.8821 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 A24 mock treatment 8062000.0 -3290000.0 -1.85 8955240.0 -1920000.0 -1.08 8104080.0 -2195966.5306122 -1.28941633984987 -2.4378 -0.9745 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B01 compound treatment 1.126712E7 -89000.0 -0.05 1.136764E7 489000.0 0.28 1.1146E7 845953.4693878 0.49672260982831 0.4168 0.7311 1965061 CMLD1_000022 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(O)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B02 compound treatment 1.173396E7 378000.0 0.21 1.2016E7 1140000.0 0.64 1.180372E7 1503673.4693878 0.882919258649558 1.0019 0.9017 1965062 CMLD1_000023 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCN7CNCC7=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B03 compound treatment 1.246436E7 1110000.0 0.62 1.241756E7 1540000.0 0.87 1.237772E7 2077673.4693878 1.21995762820407 1.5638 0.965 1965063 CMLD1_000024 COCCn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccccc5)C(=O)OC)Cc21)C(=O)N6CCCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B04 compound treatment 1.203744E7 681000.0 0.38 1.231092E7 1430000.0 0.81 1.194512E7 1645073.4693878 0.9659457838325 1.2441 0.946 1965064 CMLD1_000025 CCOC(=O)N(CC[C@H]1C[C@@H]1[C@H](NP(=O)(c2ccccc2)c3ccccc3)C4(CC(=C)c5ccccc5)CC4)S(=O)(=O)c6ccc(C)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B05 compound treatment 1.089588E7 -460000.0 -0.26 1.063452E7 -244000.0 -0.14 9242640.0 -1057406.5306122 -0.620882531417828 -0.5871 -0.8553 1965065 CMLD1_000026 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccccn7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B06 compound treatment 1.359756E7 2240000.0 1.26 1.347572E7 2600000.0 1.46 1.322944E7 2929393.4693878 1.72006619983643 2.5639 0.992 1965066 CMLD1_000027 CC(NP(=O)(c1ccccc1)c2ccccc2)C3(CC(=C)c4ccccc4)CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B07 compound treatment 1.24854E7 1130000.0 0.63 1.246668E7 1590000.0 0.89 1.210828E7 1808233.4693878 1.0617492339658 1.4953 0.9799 1965067 CMLD1_000028 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccccn7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B08 compound treatment 1.274192E7 1390000.0 0.78 1.30544E7 2180000.0 1.22 1.232836E7 2028313.4693878 1.19097467712182 1.8441 0.9823 1965068 CMLD1_000029 COC(=O)C1(C)NCC2=C(C)C(=O)C(C)C2=C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B09 compound treatment 1.269236E7 1340000.0 0.75 1.228972E7 1410000.0 0.79 1.207744E7 1777393.4693878 1.04364076128799 1.4944 0.989 1965069 CMLD1_000030 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCF 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B10 compound treatment 1.276348E7 1410000.0 0.79 1.358552E7 2710000.0 1.52 1.28966E7 2596553.4693878 1.5246309194836 2.2163 0.9654 1965070 CMLD1_000031 COC(=O)C1(Cc2ccccc2)NCC3=C(C(C)C)C(=O)C(C)C3=C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B11 compound treatment 6831320.0 -4520000.0 -2.54 7739120.0 -3140000.0 -1.77 7865800.0 -2434246.5306122 -1.42932836545518 -3.313 -0.9716 1965071 CMLD1_000032 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(cc6)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B12 compound treatment 1.356788E7 2210000.0 1.24 1.378644E7 2910000.0 1.64 1.26926E7 2392553.4693878 1.40484724807398 2.4733 0.9936 1965072 CMLD1_000033 CCCc1cc2C3C(CN(C(=O)c4ccccc4)C3(C)C(=O)OC)C(C)c2n1CCc5ccc(Cl)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B13 compound treatment 1.27628E7 1410000.0 0.79 1.248824E7 1610000.0 0.91 1.082888E7 528833.4693878 0.310517718272338 1.1585 0.9331 1965073 CMLD1_000034 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CC7CC7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B14 compound treatment 1.329236E7 1940000.0 1.09 1.308032E7 2200000.0 1.24 1.206012E7 1760073.4693878 1.03347089271537 1.94 0.997 1965074 CMLD1_000035 COc1ccc(COC2OC[C@]3(C)[C@@H]4[C@H]2CCC5C(CO)C(CO)[C@@H](C)C(=C54)CN3C(=O)OC(C)(C)C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B15 compound treatment 1.182292E7 467000.0 0.26 1.261976E7 1740000.0 0.98 1.188832E7 1588273.4693878 0.932594251792959 1.2556 0.9112 1965075 CMLD1_000036 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cc(C)n(C)n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B16 compound treatment 1.282612E7 1470000.0 0.83 1.344284E7 2560000.0 1.44 1.288892E7 2588873.4693878 1.52012141655994 2.1876 0.971 1965076 CMLD1_000037 CC1(C)C(=O)C(=C2CN3C(=O)N(CCc4ccccc4)C(=O)C3(Cc5ccc(F)cc5)C=C21)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B17 compound treatment 1.198696E7 631000.0 0.35 1.111196E7 233000.0 0.13 1.106756E7 767513.4693878 0.450664613821592 0.5405 0.9191 1965077 CMLD1_000038 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B18 compound treatment 1.353032E7 2170000.0 1.22 1.306924E7 2190000.0 1.23 1.234836E7 2048313.4693878 1.20271817431885 2.1113 0.9999 1965078 CMLD1_000039 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccccn7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B19 compound treatment 1.210556E7 749000.0 0.42 1.253052E7 1650000.0 0.93 1.190412E7 1604073.4693878 0.941871614578606 1.3236 0.9531 1965079 CMLD1_000040 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5C[C@H](O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B20 compound treatment 4858920.0 -6500000.0 -3.65 3970800.0 -6910000.0 -3.89 5341880.0 -4958166.5306122 -2.9113107377305 -6.0329 -0.9929 1965080 CMLD1_000041 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6c(O)c(C)cnc6CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B21 compound treatment 1.14222E7 66000.0 0.04 1.217316E7 1290000.0 0.73 1.151776E7 1217713.4693878 0.715010735726545 0.8549 0.8369 1965081 CMLD1_000042 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCN7CNCC7=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B22 mock treatment 1.245868E7 1100000.0 0.62 1.214464E7 1270000.0 0.71 1.123548E7 935433.4693878 0.549263016287784 1.086 0.9944 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B23 mock treatment 1.022436E7 -1130000.0 -0.64 1.11536E7 275000.0 0.15 1.016756E7 -132486.530612201 -0.0777927600443737 -0.3226 -0.4897 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 B24 mock treatment 1.03486E7 -1010000.0 -0.57 1.028208E7 -597000.0 -0.34 9738440.0 -561606.530612201 -0.329761235903666 -0.7111 -0.966 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C01 compound treatment 1.136156E7 5400.0 0.0 1.170776E7 829000.0 0.47 1.09282E7 628153.4693878 0.368835925352746 0.4841 0.8139 1965082 CMLD1_000043 CCCC=C(CCC)[C@@H](NS(=O)(=O)CC1(CCC2CC1=O)C2(C)C)c3ccc(cc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C02 compound treatment 1.20196E7 663000.0 0.37 1.280156E7 1920000.0 1.08 1.140356E7 1103513.4693878 0.647955366731553 1.2141 0.923 1965083 CMLD1_000044 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(C)o7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C03 compound treatment 1.264084E7 1280000.0 0.72 1.290268E7 2020000.0 1.14 1.194356E7 1643513.4693878 0.965029791051132 1.6315 0.9839 1965084 CMLD1_000045 CCCC=C(CCC)[C@@H](NC(=O)CCc1ccccc1)c2ccc(cc2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C04 compound treatment 1.305884E7 1700000.0 0.96 1.26578E7 1780000.0 1.0 1.219676E7 1896713.4693878 1.11370246556542 1.7733 0.9979 1965085 CMLD1_000046 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C05 compound treatment 1.293776E7 1580000.0 0.89 1.344012E7 2560000.0 1.44 1.230868E7 2008633.4693878 1.17941907587996 2.0262 0.9818 1965086 CMLD1_000047 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C06 compound treatment 1.36884E7 2330000.0 1.31 1.326568E7 2390000.0 1.34 1.248456E7 2184513.4693878 1.28269139023056 2.2726 0.9998 1965087 CMLD1_000048 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]3[C@H](CC(=O)C(=O)N(C)C)C(=O)C=C3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C07 compound treatment 1.367644E7 2320000.0 1.3 1.38794E7 3000000.0 1.69 1.409548E7 3795433.4693878 2.22858311546185 3.0143 0.977 1965088 CMLD1_000049 CCCCC=C[C@@H](NC(=O)CCc1ccccc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C08 compound treatment 1.336152E7 2010000.0 1.13 1.351396E7 2640000.0 1.48 1.285932E7 2559273.4693878 1.50274104070835 2.3743 0.9921 1965089 CMLD1_000050 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6c(C)onc6c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C09 compound treatment 1.31268E7 1770000.0 0.99 1.285972E7 1980000.0 1.12 1.245728E7 2157233.4693878 1.26667326005383 1.9493 0.9951 1965090 CMLD1_000051 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NC(=O)c2ccc(cc2)c3ccccc3)c4cccc(Cl)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C10 compound treatment 1.363756E7 2280000.0 1.28 1.308108E7 2200000.0 1.24 1.305752E7 2757473.4693878 1.61911909793083 2.3904 0.9925 1965091 CMLD1_000052 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccsc6Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C11 compound treatment 1.373536E7 2380000.0 1.34 1.314408E7 2270000.0 1.28 1.27596E7 2459553.4693878 1.444187963684 2.3416 0.9987 1965092 CMLD1_000053 C[C@]1(C[C@H]1C2CCCCC2)[C@@H](NC(=O)c3ccccc3)c4ccc(cc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C12 compound treatment 1.40608E7 2700000.0 1.52 1.340988E7 2530000.0 1.42 1.304088E7 2740833.4693878 1.60934850826291 2.6288 0.9988 1965093 CMLD1_000054 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5C[C@H](O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C13 compound treatment 1.2925E7 1570000.0 0.88 1.348052E7 2600000.0 1.46 1.220048E7 1900433.4693878 1.11588675604407 1.9986 0.9791 1965094 CMLD1_000055 CCCCC=C[C@@H](NC(=O)c1ccccc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C14 compound treatment 1.344392E7 2090000.0 1.17 1.257056E7 1690000.0 0.95 1.240836E7 2108313.4693878 1.23794866590991 1.9416 0.9941 1965095 CMLD1_000056 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cc(F)cc8COCOc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C15 compound treatment 1.28546E7 1500000.0 0.84 1.25468E7 1670000.0 0.94 1.16808E7 1380753.4693878 0.810743724876664 1.4961 0.998 1965096 CMLD1_000057 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccc(cc2)c3ccccc3)c4ccc(cc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C16 compound treatment 1.29646E7 1610000.0 0.9 1.330556E7 2430000.0 1.37 1.286988E7 2569833.4693878 1.50894160722838 2.1815 0.9796 1965097 CMLD1_000058 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cccc8ccccc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C17 compound treatment 1.269468E7 1340000.0 0.75 1.267248E7 1790000.0 1.01 1.208736E7 1787313.4693878 1.04946553589772 1.6229 0.9902 1965098 CMLD1_000059 C[C@]1(C[C@H]1C2CCCCC2)[C@@H](NS(=O)(=O)c3cccc4cccnc34)c5ccc(cc5)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C18 compound treatment 1.294488E7 1590000.0 0.89 1.314772E7 2270000.0 1.28 1.22982E7 1998153.4693878 1.17326548334872 1.93 0.9895 1965099 CMLD1_000060 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccc(O)c(OC)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C19 compound treatment 1.355744E7 2200000.0 1.24 1.30912E7 2210000.0 1.25 1.256248E7 2262433.4693878 1.32844405531016 2.1998 0.9995 1965100 CMLD1_000061 CC(C)(C)C(=O)N[C@@H](c1ccc(Cl)cc1)[C@]2(C)C[C@H]2C3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C20 compound treatment 1.23932E7 1040000.0 0.58 1.196716E7 1090000.0 0.61 1.161E7 1309953.4693878 0.769171744799208 1.1341 0.9923 1965101 CMLD1_000062 CCCCC=C[C@@H](NC(=O)OCC#C)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C21 compound treatment 1.229776E7 942000.0 0.53 1.190596E7 1030000.0 0.58 1.117144E7 871393.4693878 0.511660338262921 0.9346 0.9986 1965060 CMLD1_000063 C[C@]1(C[C@H]1C2CCCCC2)[C@@H](NC(=O)Cc3ccccc3)c4ccc(cc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C22 mock treatment 9124160.0 -2230000.0 -1.25 8275440.0 -2600000.0 -1.47 7913840.0 -2386206.5306122 -1.40112048518793 -2.3788 -0.9979 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C23 mock treatment 1.16574E7 301000.0 0.17 1.160332E7 725000.0 0.41 1.111324E7 813193.4693878 0.477486761419589 0.6088 0.9362 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 C24 mock treatment 1.049436E7 -862000.0 -0.48 1.09032E7 24400.0 0.01 1.047716E7 177113.4693878 0.103996576565518 -0.2115 -0.427 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D01 compound treatment 1.160092E7 245000.0 0.14 1.145564E7 577000.0 0.32 1.181644E7 1516393.4693878 0.890388122866864 0.7809 0.8154 1965102 CMLD1_000064 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6ccccn6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D02 compound treatment 1.299172E7 1640000.0 0.92 1.219768E7 1320000.0 0.74 1.196116E7 1661113.4693878 0.975364068584511 1.5221 0.9937 1965103 CMLD1_000065 COCCn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(F)cc5)C(=O)OC)Cc21)C(=O)N6CCCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D03 compound treatment 1.311168E7 1760000.0 0.99 1.320388E7 2330000.0 1.31 1.25226E7 2222553.4693878 1.3050275218993 2.0784 0.9921 1965104 CMLD1_000066 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(OC)c(OC)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D04 compound treatment 1.357788E7 2220000.0 1.25 1.308964E7 2210000.0 1.24 1.28764E7 2576353.4693878 1.51276998731461 2.3124 0.9956 1965105 CMLD1_000067 CCCC[C@H]1C[C@@H]1[C@H](NP(=O)(c2ccccc2)c3ccccc3)C4(CC(=C)c5ccccc5)CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D05 compound treatment 1.245644E7 1100000.0 0.62 1.267E7 1790000.0 1.01 1.244948E7 2149433.4693878 1.26209329614699 1.6676 0.9642 1965106 CMLD1_000068 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7nc8ccccc8[nH]7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D06 compound treatment 1.272496E7 1370000.0 0.77 1.268448E7 1810000.0 1.02 1.283656E7 2536513.4693878 1.48937694089814 1.8906 0.9645 1965107 CMLD1_000069 CC(=O)N1CC2(CC2)CC1c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D07 compound treatment 1.317748E7 1820000.0 1.02 1.390028E7 3020000.0 1.7 1.30386E7 2738553.4693878 1.60800974958245 2.501 0.9791 1965108 CMLD1_000070 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccc(O)c(O)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D08 compound treatment 1.349824E7 2140000.0 1.2 1.263948E7 1760000.0 0.99 1.287864E7 2578593.4693878 1.51408525900067 2.141 0.9852 1965109 CMLD1_000071 COC(=O)C1(C)NCC2=C(C(=O)C(C)C2=C1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D09 compound treatment 1.274804E7 1390000.0 0.78 1.278216E7 1900000.0 1.07 1.24298E7 2129753.4693878 1.25053769490512 1.7919 0.983 1965110 CMLD1_000072 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCn7cc(nc7C)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D10 compound treatment 1.264852E7 1290000.0 0.73 1.23686E7 1490000.0 0.84 1.22086E7 1908553.4693878 1.12065461590606 1.5503 0.9832 1965111 CMLD1_000073 COC(=O)C1(Cc2ccccc2)NCC3=C(C(=O)C(C)C3=C1)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D11 compound treatment 1.316988E7 1810000.0 1.02 1.289748E7 2020000.0 1.14 1.1943E7 1642953.4693878 0.964700973129615 1.8012 0.9976 1965112 CMLD1_000074 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccccn6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D12 compound treatment 1.469152E7 3340000.0 1.87 1.482764E7 3950000.0 2.22 1.408484E7 3784793.4693878 2.22233557495304 3.648 0.997 1965113 CMLD1_000075 CCCc1cc2C3C(CN(C(=O)c4ccccc4)C3(C)C(=O)OC)C(C)c2n1Cc5ccco5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D13 compound treatment 1.31912E7 1840000.0 1.03 1.281932E7 1940000.0 1.09 1.284468E7 2544633.4693878 1.49414480076013 2.0884 0.9858 1965057 CMLD1_000076 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(C)c(F)c6F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D14 compound treatment 1.43628E7 3010000.0 1.69 1.3995E7 3120000.0 1.75 1.318296E7 2882913.4693878 1.69277431235055 2.9651 0.9998 1965114 CMLD1_000077 C[C@@H]1C(CO)C(CO)C2CC[C@H]3C(OCc4ccc(F)cc4C(F)(F)F)OC[C@]5(C)[C@H]3C2=C1CN5C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D15 compound treatment 1.331216E7 1960000.0 1.1 1.275888E7 1880000.0 1.06 1.357508E7 3275033.4693878 1.92301731839535 2.3556 0.9597 1965115 CMLD1_000078 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cc(C)n(C)n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D16 compound treatment 1.271276E7 1360000.0 0.76 1.30746E7 2200000.0 1.24 1.257004E7 2269993.4693878 1.33288309725063 1.9231 0.9757 1965116 CMLD1_000079 CC(=C1[C@H]2C(=C(C1=O)c3ccccc3)CN4C(=O)N(CCc5ccccc5)C(=O)[C@]24Cc6ccc(F)cc6)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D17 compound treatment 1.121924E7 -137000.0 -0.08 1.111352E7 235000.0 0.13 1.130812E7 1008073.4693878 0.591915398107366 0.3736 0.6112 1965117 CMLD1_000080 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCSCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D18 compound treatment 1.349536E7 2140000.0 1.2 1.369936E7 2820000.0 1.59 1.314444E7 2844393.4693878 1.67015633674909 2.5746 0.9907 1965118 CMLD1_000081 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(cc7)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D19 compound treatment 1.341548E7 2060000.0 1.16 1.255472E7 1680000.0 0.94 1.15462E7 1246153.4693878 0.73170998874071 1.6349 0.9835 1965119 CMLD1_000082 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cc(C)n(C)n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D20 compound treatment 1.269516E7 1340000.0 0.75 1.294108E7 2060000.0 1.16 1.239908E7 2099033.4693878 1.23249968321049 1.816 0.9802 1965120 CMLD1_000083 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cc(C)n(C)n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D21 compound treatment 1.1993E7 637000.0 0.36 1.13008E7 422000.0 0.24 1.098336E7 683313.4693878 0.401224490622132 0.5753 0.979 1965121 CMLD1_000084 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCF 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D22 mock treatment 1.31322E7 1780000.0 1.0 1.269424E7 1820000.0 1.02 1.008564E7 -214406.530612201 -0.125894124563374 1.0933 0.7626 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D23 mock treatment 1.179672E7 441000.0 0.25 1.14202E7 541000.0 0.3 1.060832E7 308273.4693878 0.181010431183585 0.4233 0.9793 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 D24 mock treatment 1.202252E7 666000.0 0.37 1.17496E7 871000.0 0.49 1.105952E7 759473.4693878 0.445943727948389 0.7566 0.9941 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E01 compound treatment 1.20756E7 719000.0 0.4 1.23518E7 1470000.0 0.83 1.170476E7 1404713.4693878 0.824812434518696 1.1882 0.9603 1965122 CMLD1_000085 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1cccc2cccnc12)c3ccc(cc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E02 compound treatment 1.263784E7 1280000.0 0.72 1.25842E7 1710000.0 0.96 1.264332E7 2343273.4693878 1.37591127098052 1.7643 0.9664 1965123 CMLD1_000086 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(C)c(F)c6F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E03 compound treatment 1.22274E7 871000.0 0.49 1.25582E7 1680000.0 0.95 1.17924E7 1492353.4693878 0.876272439236044 1.3342 0.9677 1965124 CMLD1_000087 CCCC=C(CCC)[C@@H](NC(=O)c1ccc(cc1)C(F)(F)F)c2ccc(cc2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E04 compound treatment 1.257552E7 1220000.0 0.68 1.318356E7 2300000.0 1.3 1.234968E7 2049633.4693878 1.20349324513385 1.8393 0.9693 1965125 CMLD1_000088 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E05 compound treatment 1.302116E7 1670000.0 0.94 1.231652E7 1440000.0 0.81 1.197776E7 1677713.4693878 0.985111171258039 1.5759 0.9967 1965126 CMLD1_000089 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1ccc(cc1)C(F)(F)F)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E06 compound treatment 1.284616E7 1490000.0 0.84 1.275756E7 1880000.0 1.06 1.218096E7 1880913.4693878 1.10442510277978 1.7314 0.9933 1965127 CMLD1_000090 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(OC)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E07 compound treatment 1.343508E7 2080000.0 1.17 1.299012E7 2110000.0 1.19 1.309652E7 2796473.4693878 1.64201891746503 2.3084 0.9868 1965128 CMLD1_000091 CCCCC=C[C@@H](NC(=O)C(C)(C)C)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E08 compound treatment 1.340144E7 2050000.0 1.15 1.336488E7 2490000.0 1.4 1.293548E7 2635433.4693878 1.54746027803461 2.3646 0.9928 1965129 CMLD1_000092 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCCNc7ncc(cc7Cl)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E09 compound treatment 1.3303E7 1950000.0 1.09 1.355892E7 2680000.0 1.51 1.289748E7 2597433.4693878 1.52514763336027 2.3829 0.9896 1965130 CMLD1_000093 CCCC=C(CCC)[C@@H](NC(=O)c1ccc(cc1)C(=O)OC)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E10 compound treatment 1.3117E7 1760000.0 0.99 1.350832E7 2630000.0 1.48 1.299944E7 2699393.4693878 1.58501598207068 2.3407 0.982 1965131 CMLD1_000094 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(OC(F)(F)F)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E11 compound treatment 1.290584E7 1550000.0 0.87 1.243288E7 1550000.0 0.87 1.243472E7 2134673.4693878 1.25342659521559 1.7313 0.9843 1965060 CMLD1_000095 C[C@]1(C[C@H]1C2CCCCC2)[C@@H](NC(=O)Cc3ccccc3)c4ccc(cc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E12 compound treatment 1.414328E7 2790000.0 1.57 1.31608E7 2280000.0 1.28 1.36074E7 3307353.4693878 1.94199480986574 2.7667 0.9861 1965132 CMLD1_000096 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6ccccn6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E13 compound treatment 1.500952E7 3650000.0 2.05 1.377652E7 2900000.0 1.63 1.226696E7 1966913.4693878 1.15492214072697 2.7933 0.9751 1965133 CMLD1_000097 CCCCC=C[C@@H](NC(=O)OCc1ccccc1Cl)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E14 compound treatment 1.315556E7 1800000.0 1.01 1.359908E7 2720000.0 1.53 1.097932E7 679273.4693878 0.398852304188333 1.6979 0.9043 1965134 CMLD1_000098 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E15 compound treatment 1.344216E7 2090000.0 1.17 1.323004E7 2350000.0 1.32 1.193212E7 1632073.4693878 0.958312510654436 1.9939 0.9916 1965135 CMLD1_000099 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2cccs2)c3ccc(cc3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E16 compound treatment 1.283188E7 1480000.0 0.83 1.212564E7 1250000.0 0.7 1.161204E7 1311993.4693878 0.770369581513304 1.3285 0.9977 1965136 CMLD1_000100 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cccc7ccccc67 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E17 compound treatment 1.26172E7 1260000.0 0.71 1.210004E7 1220000.0 0.69 1.167044E7 1370393.4693878 0.804660593328607 1.2704 0.9976 1965137 CMLD1_000101 CC(=CC1CCCCC1)[C@@H](NC(=O)c2cccnc2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E18 compound treatment 1.28474E7 1490000.0 0.84 1.227612E7 1400000.0 0.79 1.203816E7 1738113.4693878 1.02057653279304 1.5269 0.9936 1965138 CMLD1_000102 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(OC(F)(F)F)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E19 compound treatment 1.2329E7 973000.0 0.55 1.249048E7 1610000.0 0.91 1.338104E7 3080993.4693878 1.80908190858985 1.8837 0.8986 1965139 CMLD1_000103 C[C@]1(C[C@H]1C2CCCCC2)[C@@H](NC(=O)c3ccc(cc3)c4ccccc4)c5ccc(Cl)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E20 compound treatment 1.197308E7 617000.0 0.35 1.170108E7 822000.0 0.46 1.119776E7 897713.4693878 0.527114780574202 0.7716 0.9862 1965140 CMLD1_000104 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccsc6Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E21 compound treatment 1.275992E7 1400000.0 0.79 1.172128E7 842000.0 0.47 1.159824E7 1298193.4693878 0.762266568447359 1.1691 0.9785 1965141 CMLD1_000105 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NC(=O)c2ccccc2)c3cccc(Cl)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E22 mock treatment 1.227036E7 914000.0 0.51 1.17498E7 871000.0 0.49 1.102E7 719953.4693878 0.422738577487075 0.8236 0.9967 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E23 mock treatment 1.205632E7 700000.0 0.39 1.231904E7 1440000.0 0.81 1.138296E7 1082913.4693878 0.63585956461862 1.0622 0.9632 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 E24 mock treatment 1.106808E7 -288000.0 -0.16 1.12654E7 387000.0 0.22 1.02624E7 -37646.5306122005 -0.022105096336098 0.0195 0.0715 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F01 compound treatment 1.226868E7 913000.0 0.51 1.236468E7 1490000.0 0.84 1.134144E7 1041393.4693878 0.611480064437604 1.1319 0.9792 1965142 CMLD1_000106 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCN6CCOCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F02 compound treatment 1.277584E7 1420000.0 0.8 1.33734E7 2490000.0 1.4 1.215424E7 1854193.4693878 1.08873579052456 1.8997 0.9754 1965143 CMLD1_000107 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cc(F)cc8COCOc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F03 compound treatment 1.28264E7 1470000.0 0.83 1.26834E7 1800000.0 1.02 1.17914E7 1491353.4693878 0.875685264376193 1.5688 0.9961 1965144 CMLD1_000108 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(OC)c(OC)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F04 compound treatment 1.258756E7 1230000.0 0.69 1.287328E7 1990000.0 1.12 1.24104E7 2110353.4693878 1.23914650262401 1.7629 0.9743 1965145 CMLD1_000109 CCCC[C@H]1C[C@@H]1[C@H](NP(=O)(c2ccccc2)c3ccccc3)C4(CC(=C)c5cccc(OC)c5)CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F05 compound treatment 1.275508E7 1400000.0 0.79 1.184712E7 968000.0 0.55 1.15756E7 1275553.4693878 0.748972929620331 1.2008 0.9885 1965146 CMLD1_000110 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccccn7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F06 compound treatment 1.270032E7 1340000.0 0.75 1.359964E7 2720000.0 1.53 1.291476E7 2614713.4693878 1.53529401493849 2.2066 0.9609 1965147 CMLD1_000111 CC1N(CC(O)(CC21CC2)c3ccccc3)P(=O)(c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F07 compound treatment 1.365704E7 2300000.0 1.29 1.326344E7 2380000.0 1.34 1.34194E7 3119353.4693878 1.83160593621374 2.5786 0.9869 1965148 CMLD1_000112 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(nc6)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F08 compound treatment 1.332292E7 1970000.0 1.1 1.327536E7 2400000.0 1.35 1.308952E7 2789473.4693878 1.63790869344607 2.3623 0.9875 1965149 CMLD1_000113 CCCCCC1=C2CNC(C)(C=C2C(C)C1=O)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F09 compound treatment 1.327424E7 1920000.0 1.08 1.314776E7 2270000.0 1.28 1.240244E7 2102393.4693878 1.23447259073959 2.0721 0.9974 1965150 CMLD1_000114 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7c(O)c(C)cnc7CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F10 compound treatment 1.351744E7 2160000.0 1.21 1.354356E7 2660000.0 1.5 1.288904E7 2588993.4693878 1.52019187754312 2.4446 0.9951 1965151 CMLD1_000115 CCCCCC1=C2CNC(Cc3ccccc3)(C=C2C(C)C1=O)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F11 compound treatment 1.272272E7 1370000.0 0.77 1.20754E7 1200000.0 0.67 1.2509E7 2208953.4693878 1.29704194380532 1.5809 0.9576 1965152 CMLD1_000116 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccccn6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F12 compound treatment 1.39566E7 2600000.0 1.46 1.342684E7 2550000.0 1.43 1.281108E7 2511033.4693878 1.47441572546913 2.5226 0.9999 1965153 CMLD1_000117 CCCc1cc2C3C(CN(C(=O)c4ccccc4)C3(C)C(=O)OC)C(C)c2n1Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F13 compound treatment 1.279856E7 1440000.0 0.81 1.206728E7 1190000.0 0.67 1.169852E7 1398473.4693878 0.821148463393225 1.3281 0.9959 1965154 CMLD1_000118 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(Cl)c(c6)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F14 compound treatment 1.353504E7 2180000.0 1.22 1.365716E7 2780000.0 1.56 1.248508E7 2185033.4693878 1.28299672115769 2.3503 0.9941 1965155 CMLD1_000119 C[C@@H]1C(COC(=O)C)C(COC(=O)C)C2CC[C@H]3C(OCc4ccc(F)cc4C(F)(F)F)OC[C@]5(C)[C@H]3C2=C1CN5C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F15 compound treatment 1.277648E7 1420000.0 0.8 1.20726E7 1190000.0 0.67 1.185892E7 1558873.4693878 0.915331310913337 1.377 0.9923 1965156 CMLD1_000120 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(O)c(OC)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F16 compound treatment 1.367168E7 2320000.0 1.3 1.329764E7 2420000.0 1.36 1.320076E7 2900713.4693878 1.7032260248559 2.5204 0.9927 1965157 CMLD1_000121 CC1(C)C(=O)C(=C2CN3C(=O)N(CCc4ccccc4)C(=O)C3(Cc5ccc(cc5)C(F)(F)F)C=C21)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F17 compound treatment 1.303592E7 1680000.0 0.94 1.155884E7 680000.0 0.38 1.113768E7 837633.4693878 0.491837314994349 1.0497 0.9283 1965158 CMLD1_000122 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCSCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F18 compound treatment 1.2541E7 1180000.0 0.67 1.264916E7 1770000.0 1.0 1.20816E7 1781553.4693878 1.04608340870497 1.5635 0.9829 1965150 CMLD1_000123 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7c(O)c(C)cnc7CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F19 compound treatment 1.283536E7 1480000.0 0.83 1.215E7 1270000.0 0.72 1.094484E7 644793.4693878 0.378606515020668 1.1114 0.9581 1965159 CMLD1_000124 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCSCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F20 compound treatment 1.075388E7 -602000.0 -0.34 1.013248E7 -746000.0 -0.42 1.10428E7 742753.4693878 0.436126164291679 -0.1861 -0.2682 1965160 CMLD1_000125 COC(=O)Cn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(F)cc5)C(=O)OC)Cc21)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F21 compound treatment 1.241024E7 1050000.0 0.59 1.18328E7 954000.0 0.54 1.108032E7 780273.4693878 0.458156965033292 0.9164 0.9946 1965161 CMLD1_000126 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccc(O)c(O)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F22 mock treatment 1.30842E7 1730000.0 0.97 1.28546E7 1980000.0 1.11 1.15972E7 1297153.4693878 0.761655906593114 1.6422 0.9887 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F23 mock treatment 1.096612E7 -390000.0 -0.22 1.06384E7 -240000.0 -0.14 1.049844E7 198393.4693878 0.116491657583149 -0.1374 -0.486 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 F24 mock treatment 1.12514E7 -105000.0 -0.06 1.143396E7 555000.0 0.31 1.052748E7 227433.4693878 0.133543215513224 0.2236 0.6482 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G01 compound treatment 1.23442E7 988000.0 0.55 1.231468E7 1440000.0 0.81 1.12776E7 977553.4693878 0.573994821384711 1.1185 0.9845 1965162 CMLD1_000127 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G02 compound treatment 1.250924E7 1150000.0 0.65 1.251008E7 1630000.0 0.92 1.234364E7 2043593.4693878 1.19994670898035 1.5969 0.9714 1965163 CMLD1_000128 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCCNc7ncc(cc7Cl)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G03 compound treatment 1.163732E7 281000.0 0.16 1.28644E7 1990000.0 1.12 1.231228E7 2012233.4693878 1.18153290537542 1.4186 0.8682 1965164 CMLD1_000129 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1ccccc1)c2ccc(cc2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G04 compound treatment 1.25116E7 1160000.0 0.65 1.169916E7 820000.0 0.46 1.199492E7 1694873.4693878 0.995187091853083 1.2159 0.9539 1965165 CMLD1_000130 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]3C(=C)C(=O)C=C3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G05 compound treatment 1.285608E7 1500000.0 0.84 1.22666E7 1390000.0 0.78 1.341984E7 3119793.4693878 1.83186429315207 1.9951 0.9226 1965166 CMLD1_000131 CCCC=C(CCC)[C@@H](NS(=O)(=O)CC)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G06 compound treatment 1.483172E7 3480000.0 1.95 1.299432E7 2120000.0 1.19 1.26172E7 2317153.4693878 1.36057426364121 2.6001 0.9772 1965167 CMLD1_000132 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@H]3[C@H](CC(=O)C(=O)N4CCCC4)C(=O)C[C@H]3CN1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G07 compound treatment 1.36428E7 2290000.0 1.28 1.394932E7 3070000.0 1.73 1.44128E7 4112753.4693878 2.4149054419898 3.1337 0.9685 1965168 CMLD1_000133 CCCCC=C[C@@H](NC(=O)c1ccc(cc1)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G08 compound treatment 1.346984E7 2110000.0 1.19 1.371124E7 2830000.0 1.59 1.301728E7 2717233.4693878 1.59549118157043 2.5271 0.9914 1965169 CMLD1_000134 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7c[nH]c8ccccc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G09 compound treatment 1.297676E7 1620000.0 0.91 1.263676E7 1760000.0 0.99 1.200884E7 1708793.4693878 1.00336056590221 1.6762 0.9991 1965170 CMLD1_000135 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccco2)c3ccccc3C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G10 compound treatment 1.276796E7 1410000.0 0.79 1.28636E7 1980000.0 1.12 1.277076E7 2470713.4693878 1.45074083511994 1.9405 0.9725 1965171 CMLD1_000136 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cc(F)c(F)c(F)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G11 compound treatment 1.214756E7 791000.0 0.44 1.192416E7 1050000.0 0.59 1.108052E7 780473.4693878 0.458274400005262 0.861 0.9916 1965172 CMLD1_000137 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccccc2)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G12 compound treatment 1.317028E7 1810000.0 1.02 1.40424E7 3160000.0 1.78 1.25452E7 2245153.4693878 1.31829767373193 2.3776 0.9749 1965173 CMLD1_000138 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(Cl)c(c6)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G13 compound treatment 1.220404E7 848000.0 0.48 1.235644E7 1480000.0 0.83 1.238548E7 2085433.4693878 1.22451410511652 1.4622 0.9403 1965174 CMLD1_000139 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccco2)c3ccc(cc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G14 compound treatment 1.406536E7 2710000.0 1.52 1.30402E7 2160000.0 1.22 1.262064E7 2320593.4693878 1.3625941451591 2.3677 0.9959 1965175 CMLD1_000140 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6c(O)c(C)cnc6CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G15 compound treatment 1.344084E7 2080000.0 1.17 1.275864E7 1880000.0 1.06 1.27114E7 2411353.4693878 1.41588613543918 2.1044 0.9925 1965176 CMLD1_000141 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccccc2)c3ccc(cc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G16 compound treatment 1.288636E7 1530000.0 0.86 1.245912E7 1580000.0 0.89 1.220716E7 1907113.4693878 1.11980908410787 1.6563 0.9927 1965177 CMLD1_000142 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(nc7)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G17 compound treatment 1.316968E7 1810000.0 1.02 1.287612E7 2000000.0 1.12 1.238192E7 2081873.4693878 1.22242376261545 1.943 0.9973 1965178 CMLD1_000143 CC(=CC1CCCCC1)[C@@H](NC(=O)c2ccc(cc2)C(F)(F)F)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G18 compound treatment 1.499204E7 3640000.0 2.04 1.296024E7 2080000.0 1.17 1.238428E7 2084233.4693878 1.2238094952847 2.5621 0.9655 1965179 CMLD1_000144 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(OC(F)(F)F)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G19 compound treatment 1.4018E7 2660000.0 1.5 1.211352E7 1230000.0 0.7 1.129556E7 995513.4693878 0.584540481867637 1.602 0.9158 1965180 CMLD1_000145 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccccc2)c3ccccc3C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G20 compound treatment 1.309576E7 1740000.0 0.98 1.15882E7 709000.0 0.4 1.140696E7 1106913.4693878 0.649951761255046 1.1699 0.9438 1965181 CMLD1_000146 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccc(OC)c(Br)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G21 compound treatment 1.264952E7 1290000.0 0.73 1.067432E7 -204000.0 -0.12 1.025172E7 -48326.5306122005 -0.0283761238393074 0.3366 0.4573 1965182 CMLD1_000147 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]3[C@H](CC(=O)C(=O)N4CCCC4)C(=O)C[C@H]3CN1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G22 mock treatment 1.235192E7 996000.0 0.56 1.111016E7 231000.0 0.13 1.121672E7 916673.4693878 0.538247615916978 0.7089 0.9006 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G23 mock treatment 1.138076E7 24600.0 0.01 9254280.0 -1620000.0 -0.91 6793880.0 -3506166.5306122 -2.05873284122674 -1.7086 -0.7585 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 G24 mock treatment 1.18356E7 479000.0 0.27 1.193928E7 1060000.0 0.6 1.117972E7 879673.4693878 0.516522146102488 0.7983 0.9572 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H01 compound treatment 1.145696E7 101000.0 0.06 1.221168E7 1330000.0 0.75 1.21414E7 1841353.4693878 1.08119646532407 1.0901 0.8276 1965183 CMLD1_000148 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccccn6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H02 compound treatment 1.233084E7 975000.0 0.55 1.300524E7 2130000.0 1.2 1.203512E7 1735073.4693878 1.0187915212191 1.5954 0.9585 1965184 CMLD1_000149 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(nc7)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H03 compound treatment 1.246296E7 1110000.0 0.62 1.284568E7 1970000.0 1.11 1.185788E7 1557833.4693878 0.914720649059092 1.5263 0.9753 1965185 CMLD1_000150 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccccn7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H04 compound treatment 1.132892E7 -27200.0 -0.02 1.189496E7 1020000.0 0.57 1.051152E7 211473.4693878 0.124171904750001 0.3931 0.6714 1965186 CMLD1_000151 CCCC[C@H]1C[C@@H]1[C@@H]2N(C[C@](O)(CC32CC3)c4ccccc4)P(=O)(c5ccccc5)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H05 compound treatment 1.252316E7 1170000.0 0.66 1.303464E7 2160000.0 1.21 1.135912E7 1059073.4693878 0.621861315959771 1.4381 0.9505 1965187 CMLD1_000152 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7nc8ccccc8[nH]7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H06 compound treatment 1.419432E7 2840000.0 1.59 1.447184E7 3590000.0 2.02 1.175352E7 1453473.4693878 0.853443080685034 2.5808 0.9513 1965147 CMLD1_000153 CC1N(CC(O)(CC21CC2)c3ccccc3)P(=O)(c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H07 compound treatment 1.437784E7 3020000.0 1.7 1.336004E7 2480000.0 1.4 1.28924E7 2592353.4693878 1.52216478507222 2.6651 0.9968 1965188 CMLD1_000154 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7c(O)c(C)cnc7CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H08 compound treatment 1.363272E7 2280000.0 1.28 1.512108E7 4240000.0 2.39 1.281504E7 2514993.4693878 1.47674093791415 2.9696 0.9625 1965189 CMLD1_000155 CCCC1(NCC2=C(C)C(=O)C(C)C2=C1)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H09 compound treatment 1.369208E7 2340000.0 1.31 1.305104E7 2170000.0 1.22 1.238264E7 2082593.4693878 1.22284652851454 2.1695 0.9994 1965190 CMLD1_000156 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5C[C@H](O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H10 compound treatment 1.31838E7 1830000.0 1.03 1.378936E7 2910000.0 1.64 1.305128E7 2751233.4693878 1.61545512680536 2.4713 0.9809 1965191 CMLD1_000157 COC(=O)C1(CC(C)C)NCC2=C(C)C(=O)C(C)C2=C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H11 compound treatment 1.292636E7 1570000.0 0.88 1.281632E7 1940000.0 1.09 1.151252E7 1212473.4693878 0.711933939460925 1.5499 0.9854 1965192 CMLD1_000158 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H12 compound treatment 1.338936E7 2030000.0 1.14 1.407752E7 3200000.0 1.8 1.235136E7 2051313.4693878 1.2044796988984 2.3943 0.9777 1965193 CMLD1_000159 CCCc1cc2C3C(CN(C(=O)c4ccccc4)C3(C)C(=O)OC)C(C)c2n1CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H13 compound treatment 1.298512E7 1630000.0 0.91 1.221648E7 1340000.0 0.75 1.099772E7 697673.4693878 0.409656321609593 1.1995 0.9567 1965194 CMLD1_000160 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(cc7)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H14 compound treatment 1.463244E7 3280000.0 1.84 1.367204E7 2790000.0 1.57 1.288924E7 2589193.4693878 1.52030931251509 2.848 0.9964 1965195 CMLD1_000161 C[C@@H]1C2COC(=O)OCC2C3CC[C@H]4C(OCc5ccc(F)cc5C(F)(F)F)OC[C@]6(C)[C@H]4C3=C1CN6C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H15 compound treatment 1.164724E7 291000.0 0.16 1.109148E7 213000.0 0.12 1.106772E7 767673.4693878 0.450758561799168 0.4238 0.8574 1965196 CMLD1_000162 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(C)o7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H16 compound treatment 1.34708E7 2110000.0 1.19 1.309796E7 2220000.0 1.25 1.20816E7 1781553.4693878 1.04608340870497 2.0109 0.9973 1965197 CMLD1_000163 CC(=C1[C@H]2C(=C(C1=O)c3ccccc3)CN4C(=O)N(CCc5ccccc5)C(=O)[C@]24Cc6ccc(cc6)C(F)(F)F)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H17 compound treatment 1.262796E7 1270000.0 0.71 1.098472E7 106000.0 0.06 1.09798E7 679753.4693878 0.399134148121062 0.6773 0.8255 1965198 CMLD1_000164 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5[nH]c(cc35)C(=O)N6CCCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H18 compound treatment 1.29012E7 1550000.0 0.87 1.298072E7 2100000.0 1.18 1.26142E7 2314153.4693878 1.35881273906166 1.9687 0.9844 1965199 CMLD1_000165 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CC7CC7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H19 compound treatment 1.35456E7 2190000.0 1.23 1.264116E7 1760000.0 0.99 1.149332E7 1193273.4693878 0.700660182151785 1.6873 0.9762 1965200 CMLD1_000166 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H20 compound treatment 1.472792E7 3370000.0 1.89 1.12848E7 406000.0 0.23 1.170036E7 1400313.4693878 0.822228865135351 1.7001 0.8184 1965201 CMLD1_000167 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCSCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H21 compound treatment 1.234988E7 994000.0 0.56 1.061296E7 -266000.0 -0.15 1.009052E7 -209526.530612201 -0.1230287112473 0.1648 0.279 1965202 CMLD1_000168 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6ccc(O)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H22 mock treatment 1.248416E7 1130000.0 0.63 1.24346E7 1560000.0 0.88 1.132884E7 1028793.4693878 0.60408166120348 1.2202 0.9854 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H23 mock treatment 1.191156E7 555000.0 0.31 9932560.0 -946000.0 -0.53 1.035504E7 54993.4693877995 0.0322907826805054 -0.1088 -0.176 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 H24 mock treatment 1.12578E7 -98400.0 -0.06 1.230624E7 1430000.0 0.8 1.107788E7 777833.4693878 0.456724258375255 0.6957 0.7514 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I01 compound treatment 1.146256E7 106000.0 0.06 1.184872E7 970000.0 0.55 1.088784E7 587793.4693878 0.345137548009157 0.549 0.8463 1965203 CMLD1_000169 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1cccc(c1)C(F)(F)F)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I02 compound treatment 1.2367E7 1010000.0 0.57 1.239188E7 1510000.0 0.85 1.209696E7 1796913.4693878 1.05510241455229 1.4287 0.9719 1965204 CMLD1_000170 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6nc7ccccc7[nH]6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I03 compound treatment 1.246128E7 1110000.0 0.62 1.252676E7 1650000.0 0.93 1.169076E7 1390713.4693878 0.816591986480781 1.3654 0.9873 1965205 CMLD1_000171 CCCC=C(CCC)[C@@H](NP(=O)(c1ccccc1)c2ccccc2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I04 compound treatment 1.246324E7 1110000.0 0.62 1.238336E7 1500000.0 0.85 1.17702E7 1470153.4693878 0.86323715734735 1.3464 0.9901 1965206 CMLD1_000172 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(OC(F)(F)F)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I05 compound treatment 1.26804E7 1320000.0 0.74 1.244884E7 1570000.0 0.88 1.219208E7 1892033.4693878 1.11095448722132 1.5811 0.9865 1965207 CMLD1_000173 CCCC=C(CCC)[C@@H](NC(=O)c1ccco1)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I06 compound treatment 1.281952E7 1460000.0 0.82 1.385392E7 2980000.0 1.67 1.009132E7 -208726.530612201 -0.12255897135942 1.3707 0.7332 1965208 CMLD1_000174 COCCn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(OC)cc5)C(=O)OC)Cc21)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I07 compound treatment 1.323484E7 1880000.0 1.06 1.303288E7 2150000.0 1.21 1.262624E7 2326193.4693878 1.36588232437426 2.0979 0.9946 1965209 CMLD1_000175 CCCCC=C[C@@H](NC(=O)c1ccc(cc1)C(F)(F)F)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I08 compound treatment 1.3455E7 2100000.0 1.18 1.330648E7 2430000.0 1.37 1.112712E7 827073.4693878 0.485636748474322 1.75 0.9363 1965210 CMLD1_000176 COC(=O)Cn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(OC)cc5)C(=O)OC)Cc21)C(=O)N6CCCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I09 compound treatment 1.338652E7 2030000.0 1.14 1.29806E7 2100000.0 1.18 1.193424E7 1634193.4693878 0.95955732135732 1.8955 0.9961 1965211 CMLD1_000177 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NP(=O)(c2ccccc2)c3ccccc3)c4ccc(Cl)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I10 compound treatment 1.28678E7 1510000.0 0.85 1.250588E7 1630000.0 0.92 1.20946E7 1794553.4693878 1.05371668188304 1.6274 0.9959 1965212 CMLD1_000178 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(Cl)c(c6)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I11 compound treatment 1.264092E7 1280000.0 0.72 1.258772E7 1710000.0 0.96 9791480.0 -508566.530612201 -0.298617481337165 0.7996 0.6453 1965213 CMLD1_000179 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)Cc2ccccc2)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I12 compound treatment 1.287856E7 1520000.0 0.86 1.384192E7 2960000.0 1.67 1.314564E7 2845593.4693878 1.67086094658091 2.4214 0.9643 1965214 CMLD1_000180 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cccc8ccccc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I13 compound treatment 1.313368E7 1780000.0 1.0 1.284172E7 1960000.0 1.1 1.268624E7 2386193.4693878 1.40111281596533 2.0233 0.9895 1965215 CMLD1_000181 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I14 compound treatment 1.353248E7 2180000.0 1.22 1.27238E7 1840000.0 1.04 1.204828E7 1748233.4693878 1.02651874237474 1.898 0.9967 1965216 CMLD1_000182 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@H]3[C@H](CC(=O)C(=O)N(C)C)C(=O)C[C@H]3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I15 compound treatment 1.320464E7 1850000.0 1.04 1.337132E7 2490000.0 1.4 1.265072E7 2350673.4693878 1.38025636494342 2.2064 0.9915 1965217 CMLD1_000183 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2cccs2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I16 compound treatment 1.304276E7 1690000.0 0.95 1.397948E7 3100000.0 1.75 1.268476E7 2384713.4693878 1.40024379717275 2.3631 0.9725 1965218 CMLD1_000184 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(OC)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I17 compound treatment 1.27918E7 1440000.0 0.81 1.392528E7 3050000.0 1.71 1.26E7 2299953.4693878 1.35047485605177 2.2353 0.9606 1965219 CMLD1_000185 COC(=O)c1ccc(cc1)[C@H](NC(=O)c2ccccc2)[C@]3(C)C[C@H]3C4CCCCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I18 compound treatment 1.339504E7 2040000.0 1.15 1.279876E7 1920000.0 1.08 1.268872E7 2388673.4693878 1.40256900961776 2.0949 0.9935 1965220 CMLD1_000186 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(OC(F)(F)F)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I19 compound treatment 1.228892E7 933000.0 0.52 1.278548E7 1910000.0 1.07 1.144496E7 1144913.4693878 0.672264405929387 1.3103 0.956 1965221 CMLD1_000187 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2cccs2)c3ccccc3C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I20 compound treatment 1.387108E7 2510000.0 1.41 1.186008E7 981000.0 0.55 1.134216E7 1042113.4693878 0.611902830336697 1.4877 0.9096 1965222 CMLD1_000188 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(nc6)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I21 compound treatment 1.232144E7 965000.0 0.54 8048160.0 -2830000.0 -1.59 7904240.0 -2395806.5306122 -1.4067573638425 -1.4191 -0.6469 1965223 CMLD1_000189 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CC6CC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I22 mock treatment 1.233996E7 984000.0 0.55 1.22896E7 1410000.0 0.79 1.085508E7 555033.4693878 0.325901699600436 0.9657 0.9459 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I23 mock treatment 1.14598E7 104000.0 0.06 1.028396E7 -595000.0 -0.33 1.031248E7 12433.4693877995 0.00730062064524378 -0.1555 -0.4574 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 I24 mock treatment 1.135796E7 1800.0 0.0 1.132916E7 450000.0 0.25 1.060524E7 305193.4693878 0.179201932615244 0.2504 0.8066 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J01 compound treatment 1.250952E7 1150000.0 0.65 1.172724E7 848000.0 0.48 1.066192E7 361873.4693878 0.212483003671603 0.7724 0.9279 1965224 CMLD1_000190 COC(=O)Cn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccccc5)C(=O)OC)Cc21)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J02 compound treatment 1.206968E7 714000.0 0.4 1.206672E7 1190000.0 0.67 1.149732E7 1197273.4693878 0.703008881591189 1.0233 0.9748 1965225 CMLD1_000191 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(C)o7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J03 compound treatment 1.279652E7 1440000.0 0.81 1.237856E7 1500000.0 0.84 1.147516E7 1175113.4693878 0.689997086696889 1.3529 0.9965 1965226 CMLD1_000192 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(nc7)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J04 compound treatment 1.18822E7 526000.0 0.3 1.199176E7 1110000.0 0.63 1.143196E7 1131913.4693878 0.664631132751323 0.916 0.9542 1965227 CMLD1_000193 CCCC[C@H]1C[C@@H]1[C@@H]2N([C@@](CO)(CC32CC3)c4ccccc4)P(=O)(c5ccccc5)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J05 compound treatment 1.18572E7 501000.0 0.28 1.299448E7 2120000.0 1.19 1.186444E7 1564393.4693878 0.918572516139715 1.3804 0.9021 1965228 CMLD1_000194 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccsc7Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J06 compound treatment 1.338708E7 2030000.0 1.14 1.288908E7 2010000.0 1.13 1.117608E7 876033.4693878 0.51438482961263 1.6089 0.9536 1965229 CMLD1_000195 OC1(CN(CC2(CC2)C1)P(=O)(c3ccccc3)c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J07 compound treatment 1.29014E7 1550000.0 0.87 1.313644E7 2260000.0 1.27 1.198688E7 1686833.4693878 0.99046620597988 1.8067 0.9872 1965230 CMLD1_000196 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5[nH]c(cc35)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J08 compound treatment 1.270484E7 1350000.0 0.76 1.362692E7 2750000.0 1.55 1.186968E7 1569633.4693878 0.921649312405335 1.8626 0.9534 1965231 CMLD1_000197 CCCC1(NCC2=C(C(C)C)C(=O)C(C)C2=C1)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J09 compound treatment 1.272416E7 1370000.0 0.77 1.293988E7 2060000.0 1.16 1.208728E7 1787233.4693878 1.04941856190893 1.7193 0.9865 1965232 CMLD1_000198 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J10 compound treatment 1.3023E7 1670000.0 0.94 1.359436E7 2720000.0 1.53 1.209232E7 1792273.4693878 1.05237792320258 2.0307 0.9769 1965233 CMLD1_000199 COC(=O)C1(CC(C)C)NCC2=C(C(C)C)C(=O)C(C)C2=C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J11 compound treatment 1.298172E7 1630000.0 0.91 1.2936E7 2060000.0 1.16 1.205524E7 1755193.4693878 1.0306054793993 1.7907 0.9954 1965234 CMLD1_000200 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J12 compound treatment 1.543052E7 4070000.0 2.29 1.318844E7 2310000.0 1.3 1.1824E7 1523953.4693878 0.894827164807338 2.5885 0.9311 1965235 CMLD1_000201 CCCc1cc2C3C(CN(C(=O)c4ccccc4)C3(C)C(=O)OC)C(C)c2n1Cc5cccc(Cl)c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J13 compound treatment 1.454292E7 3190000.0 1.79 1.461552E7 3740000.0 2.1 1.356464E7 3264593.4693878 1.91688721285851 3.3546 0.9978 1965236 CMLD1_000202 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(cc7)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J14 compound treatment 1.35638E7 2210000.0 1.24 1.340988E7 2530000.0 1.42 1.263284E7 2332793.4693878 1.36975767844928 2.3293 0.9983 1965237 CMLD1_000203 CC[C@@H]1C(COC(=O)C)C(COC(=O)C)C2CC[C@H]3C(OCc4ccc(F)cc4C(F)(F)F)OC[C@]5(C)[C@H]3C2=C1CN5C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J15 compound treatment 1.254172E7 1190000.0 0.67 9161640.0 -1720000.0 -0.97 1.058408E7 284033.4693878 0.166777312580795 -0.0773 -0.0652 1965238 CMLD1_000204 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J16 compound treatment 1.336036E7 2000000.0 1.13 1.2993E7 2110000.0 1.19 1.153892E7 1238873.4693878 0.727435355760994 1.757 0.9803 1965239 CMLD1_000205 CC(=C1[C@H]2C(=C(C1=O)c3ccccc3)CN4C(=O)N(CCc5ccccc5)C(=O)[C@]24C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J17 compound treatment 1.288208E7 1530000.0 0.86 1.10962E7 217000.0 0.12 9840800.0 -459246.530612201 -0.26965801724931 0.4098 0.4519 1965240 CMLD1_000206 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCSCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J18 compound treatment 1.28196E7 1460000.0 0.82 1.099944E7 121000.0 0.07 1.340548E7 3105433.4693878 1.82343246216461 1.5665 0.7828 1965241 CMLD1_000207 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCn6cc(nc6C)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J19 compound treatment 1.227528E7 919000.0 0.52 8658280.0 -2220000.0 -1.25 1.001904E7 -281006.530612201 -0.164999970229455 -0.5189 -0.3808 1965242 CMLD1_000208 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccccn7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J20 compound treatment 1.277192E7 1420000.0 0.8 1.196992E7 1090000.0 0.61 1.124688E7 946833.4693878 0.555956809690086 1.1347 0.9881 1965243 CMLD1_000209 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J21 compound treatment 1.28134E7 1460000.0 0.82 8459720.0 -2420000.0 -1.36 8110480.0 -2189566.5306122 -1.28565842074682 -1.0559 -0.5166 1965244 CMLD1_000210 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6ccc(O)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J22 mock treatment 1.32566E7 1900000.0 1.07 1.238916E7 1510000.0 0.85 1.166108E7 1361033.4693878 0.799164636640401 1.5685 0.9919 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J23 mock treatment 1.245284E7 1100000.0 0.62 8708320.0 -2170000.0 -1.22 8737720.0 -1562326.5306122 -0.917358861653832 -0.8794 -0.5338 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 J24 mock treatment 1.199728E7 641000.0 0.36 1.114136E7 263000.0 0.15 1.060928E7 309233.4693878 0.181574119049042 0.3981 0.9268 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K01 compound treatment 1.126376E7 -92400.0 -0.05 1.165152E7 773000.0 0.43 1.067832E7 378273.4693878 0.22211267137316 0.3494 0.7114 1965245 CMLD1_000211 CCCC=C(CCC)[C@@H](NP(=O)(c1ccccc1)c2ccccc2)c3ccc(cc3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K02 compound treatment 1.161632E7 260000.0 0.15 1.206816E7 1190000.0 0.67 1.240172E7 2101673.4693878 1.2340498248405 1.1834 0.8384 1965246 CMLD1_000212 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7c[nH]c8cc(F)ccc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K03 compound treatment 1.029836E7 -1060000.0 -0.59 1.202056E7 1140000.0 0.64 9260600.0 -1039446.5306122 -0.610336870934903 -0.3243 -0.304 1965247 CMLD1_000213 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1cccc2cccnc12)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K04 compound treatment 9970360.0 -1390000.0 -0.78 1.052392E7 -355000.0 -0.2 9397520.0 -902526.530612201 -0.529940889124094 -0.8707 -0.9045 1965248 CMLD1_000214 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cc(F)c(F)c(F)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K05 compound treatment 1.205084E7 695000.0 0.39 1.198556E7 1110000.0 0.62 1.1123E7 822953.4693878 0.483217588051735 0.864 0.9821 1965249 CMLD1_000215 CCCC=C(CCC)[C@@H](NC(=O)C(C)(C)C)c1ccc(cc1)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K06 compound treatment 1.286668E7 1510000.0 0.85 1.236476E7 1490000.0 0.84 1.146696E7 1166913.4693878 0.685182252846111 1.3684 0.9956 1965250 CMLD1_000216 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cc(F)c(F)c(F)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K07 compound treatment 1.249204E7 1140000.0 0.64 1.216752E7 1290000.0 0.73 1.231028E7 2010233.4693878 1.18035855565572 1.4687 0.9629 1965251 CMLD1_000217 CCCCC=C[C@@H](NC(=O)c1ccc(cc1)C(=O)OC)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K08 compound treatment 1.267808E7 1320000.0 0.74 1.237732E7 1500000.0 0.84 1.205412E7 1754073.4693878 1.02994784355627 1.5103 0.9908 1965252 CMLD1_000218 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6c[nH]c7ccc(O)cc67 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K09 compound treatment 1.21238E7 768000.0 0.43 1.24212E7 1540000.0 0.87 1.15606E7 1260553.4693878 0.740165306722565 1.1775 0.9655 1965253 CMLD1_000219 CCCC=C(CCC)[C@@H](NC(=O)Cc1ccccc1)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K10 compound treatment 1.260572E7 1250000.0 0.7 1.227088E7 1390000.0 0.78 1.168144E7 1381393.4693878 0.811119516786969 1.3259 0.9982 1965254 CMLD1_000220 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(Cl)c(c7)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K11 compound treatment 1.03584E7 -998000.0 -0.56 1.04726E7 -406000.0 -0.23 1.011812E7 -181926.530612201 -0.106822685115411 -0.5173 -0.8416 1965255 CMLD1_000221 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccco2)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K12 compound treatment 1.290488E7 1550000.0 0.87 1.245396E7 1580000.0 0.89 1.23882E7 2088153.4693878 1.22611122073531 1.722 0.9866 1965256 CMLD1_000222 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7c[nH]c8ccc(OC)cc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K13 compound treatment 1.318048E7 1820000.0 1.02 1.21804E7 1300000.0 0.73 1.162448E7 1324433.4693878 0.777674036769852 1.4636 0.9887 1965257 CMLD1_000223 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccco2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K14 compound treatment 1.294676E7 1590000.0 0.89 1.321676E7 2340000.0 1.32 1.230588E7 2005833.4693878 1.17777498627237 1.9556 0.9881 1965258 CMLD1_000224 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(nc6)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K15 compound treatment 1.220492E7 849000.0 0.48 1.175084E7 872000.0 0.49 1.148584E7 1185793.4693878 0.696268114200099 0.9606 0.984 1965259 CMLD1_000225 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2cccnc2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K16 compound treatment 1.32126E7 1860000.0 1.04 1.280372E7 1920000.0 1.08 1.095788E7 657833.4693878 0.386263275193126 1.4506 0.9343 1965260 CMLD1_000226 COC(=O)Cn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(OC)cc5)C(=O)OC)Cc21)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K17 compound treatment 1.322164E7 1870000.0 1.05 1.239404E7 1520000.0 0.85 1.194828E7 1648233.4693878 0.967801256389629 1.6562 0.9965 1965261 CMLD1_000227 COC(=O)c1ccc(cc1)[C@H](NC(=O)c2ccco2)[C@]3(C)C[C@H]3C4CCCCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K18 compound treatment 1.245932E7 1100000.0 0.62 1.232392E7 1450000.0 0.81 1.123024E7 930193.4693878 0.546186220022165 1.1427 0.9857 1965262 CMLD1_000228 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cc(F)cc8COCOc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K19 compound treatment 1.243412E7 1080000.0 0.61 1.21638E7 1280000.0 0.72 1.160192E7 1301873.4693878 0.764427371931611 1.2085 0.9954 1965263 CMLD1_000229 CCCC[C@@H]1C[C@H]1[C@@H](NP(=O)(c2ccccc2)c3ccccc3)c4ccc(Cl)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K20 compound treatment 1.200028E7 644000.0 0.36 1.169996E7 821000.0 0.46 1.093288E7 632833.4693878 0.371583903696849 0.6903 0.9936 1965264 CMLD1_000230 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(C)c(F)c7F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K21 compound treatment 1.199984E7 644000.0 0.36 9861720.0 -1020000.0 -0.57 1.078416E7 484113.4693878 0.284259258539798 0.0423 0.0576 1965265 CMLD1_000231 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(C)o6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K22 mock treatment 1.131012E7 -46000.0 -0.03 1.079076E7 -88000.0 -0.05 1.005484E7 -245206.530612201 -0.143979110246787 -0.1267 -0.8201 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K23 mock treatment 1.118348E7 -173000.0 -0.1 1.029836E7 -580000.0 -0.33 9481200.0 -818846.530612201 -0.480806096851756 -0.5222 -0.8861 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 K24 mock treatment 1.07556E7 -601000.0 -0.34 1.083724E7 -41600.0 -0.02 1.018896E7 -111086.530612201 -0.0652272180435608 -0.2459 -0.7141 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L01 compound treatment 1.171816E7 362000.0 0.2 1.201536E7 1140000.0 0.64 1.170412E7 1404073.4693878 0.824436642608391 0.9628 0.9055 1965266 CMLD1_000232 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCN7CNCC7=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L02 compound treatment 1.170648E7 350000.0 0.2 1.21224E7 1240000.0 0.7 1.206536E7 1765313.4693878 1.03654768898099 1.1162 0.8816 1965267 CMLD1_000233 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L03 compound treatment 1.242952E7 1070000.0 0.6 1.2493E7 1610000.0 0.91 1.158224E7 1282193.4693878 0.752871770689742 1.3074 0.9866 1965268 CMLD1_000234 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(O)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L04 compound treatment 1.308632E7 1730000.0 0.97 1.272404E7 1850000.0 1.04 1.203548E7 1735433.4693878 1.01900290416864 1.7491 0.9996 1965269 CMLD1_000235 CCCC[C@H]1C[C@@H]1[C@@H]2N([C@@H](CC32CC3)c4cccc(OC)c4)C(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L05 compound treatment 1.263484E7 1280000.0 0.72 1.2867E7 1990000.0 1.12 1.189092E7 1590873.4693878 0.934120906428571 1.6001 0.9846 1965270 CMLD1_000236 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7cc8ccccc8[nH]7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L06 compound treatment 1.44822E7 3130000.0 1.76 1.29124E7 2030000.0 1.14 1.209416E7 1794113.4693878 1.0534583249447 2.2829 0.9731 1965271 CMLD1_000237 C=C(CC1(CNP(=O)(c2ccccc2)c3ccccc3)CC1)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L07 compound treatment 9591560.0 -1760000.0 -0.99 1.033032E7 -548000.0 -0.31 9756640.0 -543406.530612201 -0.319074653454377 -0.9347 -0.8607 1965272 CMLD1_000238 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L08 compound treatment 1.332464E7 1970000.0 1.11 1.33828E7 2500000.0 1.41 1.24494E7 2149353.4693878 1.2620463221582 2.1808 0.9952 1965273 CMLD1_000239 CCCC1(NCC2=C(C(=O)C(C)C2=C1)c3ccccc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L09 compound treatment 1.307216E7 1720000.0 0.96 1.328924E7 2410000.0 1.36 1.272268E7 2422633.4693878 1.4225094678583 2.1611 0.9871 1965274 CMLD1_000240 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(O)c(OC)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L10 compound treatment 1.408648E7 2730000.0 1.53 1.387916E7 3000000.0 1.69 1.326396E7 2963913.4693878 1.74033547599849 2.8653 0.9986 1965275 CMLD1_000241 COC(=O)C1(CC(C)C)NCC2=C(C(=O)C(C)C2=C1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L11 compound treatment 1.292576E7 1570000.0 0.88 1.347408E7 2600000.0 1.46 1.307232E7 2772273.4693878 1.62780928585663 2.2923 0.972 1965276 CMLD1_000242 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCF 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L12 compound treatment 1.360196E7 2250000.0 1.26 1.306012E7 2180000.0 1.23 1.259804E7 2297993.4693878 1.34932399332646 2.2162 0.9992 1965277 CMLD1_000243 CCCc1cc2C3C(CN(C(=O)c4ccccc4)C3(C)C(=O)OC)C(C)c2n1Cc5cc(F)cc(F)c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L13 compound treatment 1.308584E7 1730000.0 0.97 1.317144E7 2290000.0 1.29 1.278472E7 2484673.4693878 1.45893779616346 2.1483 0.987 1965278 CMLD1_000244 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L14 compound treatment 1.330728E7 1950000.0 1.1 1.313496E7 2260000.0 1.27 1.175932E7 1459273.4693878 0.85684869487217 1.8607 0.9878 1965279 CMLD1_000245 CC[C@@H]1C2COC(=O)OCC2C3CC[C@H]4C(OCc5ccc(F)cc5C(F)(F)F)OC[C@]6(C)[C@H]4C3=C1CN6C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L15 compound treatment 1.33736E7 2020000.0 1.13 1.290444E7 2030000.0 1.14 1.224764E7 1947593.4693878 1.14357792243465 1.9728 1.0 1965280 CMLD1_000246 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5C[C@H](O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L16 compound treatment 1.32916E7 1940000.0 1.09 1.33056E7 2430000.0 1.37 1.240736E7 2107313.4693878 1.23736149105006 2.1307 0.9957 1965281 CMLD1_000247 CC(=C1[C@H]2C(=C(C1=O)c3ccccc3)CN4C(=O)N(CCc5ccccc5)C(=O)[C@]24Cc6ccccc6)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L17 compound treatment 1.267028E7 1310000.0 0.74 1.237968E7 1500000.0 0.84 1.163532E7 1335273.4693878 0.784039012250637 1.3666 0.9985 1965282 CMLD1_000248 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCSC(=N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L18 compound treatment 1.3912E7 2560000.0 1.44 1.299548E7 2120000.0 1.19 1.219056E7 1890513.4693878 1.11006198143435 2.1576 0.9939 1965079 CMLD1_000249 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5C[C@H](O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L19 compound treatment 1.235872E7 1000000.0 0.56 1.066448E7 -214000.0 -0.12 1.008332E7 -216726.530612201 -0.127256370238228 0.182 0.3086 1965283 CMLD1_000250 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7c[nH]c8cc(F)ccc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L20 compound treatment 1.172948E7 373000.0 0.21 1.341356E7 2530000.0 1.43 1.181604E7 1515993.4693878 0.890153252922923 1.4588 0.8608 1965284 CMLD1_000251 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(cc6)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L21 compound treatment 1.156324E7 207000.0 0.12 1.097644E7 97600.0 0.05 1.02878E7 -12246.5306122005 -0.0071908548958807 0.0947 0.7352 1965285 CMLD1_000252 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCN6CNCC6=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L22 mock treatment 1.219936E7 843000.0 0.47 1.163332E7 755000.0 0.42 1.060956E7 309513.4693878 0.181738528009801 0.6236 0.9425 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L23 mock treatment 1.1549E7 193000.0 0.11 1.144976E7 571000.0 0.32 1.053964E7 239593.4693878 0.140683261809014 0.3293 0.8969 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 L24 mock treatment 1.07282E7 -628000.0 -0.35 1.182012E7 941000.0 0.53 1.079964E7 499593.4693878 0.293348725370293 0.2716 0.3876 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M01 compound treatment 1.217824E7 822000.0 0.46 1.134132E7 463000.0 0.26 1.094108E7 641033.4693878 0.376398737547628 0.6342 0.9755 1965286 CMLD1_000253 CCCC=C(CCC)[C@@H](NC(=O)c1cccs1)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M02 compound treatment 1.131052E7 -45600.0 -0.03 1.213492E7 1260000.0 0.71 1.14738E7 1173753.4693878 0.689198528887492 0.7913 0.8012 1965287 CMLD1_000254 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]3[C@H](CC(=O)C(=O)N4CCCC4)C(=O)C=C3CN1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M03 compound treatment 1.183416E7 478000.0 0.27 1.23738E7 1490000.0 0.84 1.130008E7 1000033.4693878 0.587194512234164 0.9799 0.9238 1965288 CMLD1_000255 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1ccc(cc1)C(F)(F)F)c2ccc(cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M04 compound treatment 1.169524E7 339000.0 0.19 1.268648E7 1810000.0 1.02 1.160928E7 1309233.4693878 0.768748978900115 1.1413 0.8851 1965289 CMLD1_000256 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7c(C)onc7c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M05 compound treatment 1.25204E7 1160000.0 0.65 1.257456E7 1700000.0 0.95 1.15106E7 1210553.4693878 0.710806563730011 1.339 0.9861 1965290 CMLD1_000257 CCCC=C(CCC)[C@@H](NC(=O)c1ccc(cc1)c2ccccc2)c3ccc(cc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M06 compound treatment 1.250908E7 1150000.0 0.65 1.233188E7 1450000.0 0.82 1.140616E7 1106113.4693878 0.649482021367165 1.2211 0.9936 1965090 CMLD1_000258 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NC(=O)c2ccc(cc2)c3ccccc3)c4cccc(Cl)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M07 compound treatment 1.201152E7 655000.0 0.37 1.274688E7 1870000.0 1.05 1.212256E7 1822513.4693878 1.07013409096447 1.4375 0.9305 1965291 CMLD1_000259 CCCCC=C[C@@H](NC(=O)c1ccco1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M08 compound treatment 1.318544E7 1830000.0 1.03 1.29874E7 2110000.0 1.19 1.247504E7 2174993.4693878 1.27710148556478 2.0158 0.9961 1965292 CMLD1_000260 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@H]3[C@H](CC(=O)C(=O)N(C)C)C(=O)C=C3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M09 compound treatment 1.319412E7 1840000.0 1.03 1.290716E7 2030000.0 1.14 1.145352E7 1153473.4693878 0.677290622729712 1.6463 0.9789 1965293 CMLD1_000261 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NC(=O)OCc2ccccc2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M10 compound treatment 1.351684E7 2160000.0 1.21 1.269216E7 1810000.0 1.02 1.181556E7 1515513.4693878 0.889871408990195 1.8038 0.9919 1965294 CMLD1_000262 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCCNc6ccc(cc6Cl)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M11 compound treatment 1.259856E7 1240000.0 0.7 1.18994E7 1020000.0 0.57 1.1399E7 1098953.4693878 0.645277849370632 1.1071 0.9969 1965295 CMLD1_000263 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2cccnc2)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M12 compound treatment 1.207088E7 715000.0 0.4 1.014688E7 -732000.0 -0.41 1.09476E7 647553.4693878 0.380227117633857 0.2134 0.3095 1965296 CMLD1_000264 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6ccc(OC)c(Br)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M13 compound treatment 1.32788E7 1920000.0 1.08 1.34032E7 2520000.0 1.42 1.282868E7 2528633.4693878 1.48475000300251 2.3011 0.9912 1965297 CMLD1_000265 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccccc2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M14 compound treatment 1.286748E7 1510000.0 0.85 1.318356E7 2300000.0 1.3 1.184596E7 1545913.4693878 0.907721524729667 1.7632 0.9814 1965298 CMLD1_000266 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccsc6Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M15 compound treatment 1.309396E7 1740000.0 0.98 1.310476E7 2230000.0 1.25 1.238676E7 2086713.4693878 1.22526568893713 1.9944 0.9942 1965299 CMLD1_000267 CCCC[C@@H]1C[C@H]1[C@@H](NS(=O)(=O)c2cccc3cccnc23)c4ccc(cc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M16 compound treatment 1.31864E7 1830000.0 1.03 1.314308E7 2260000.0 1.27 1.239276E7 2092713.4693878 1.22878873809623 2.0388 0.9959 1965300 CMLD1_000268 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6ccc(O)c(O)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M17 compound treatment 1.317088E7 1810000.0 1.02 1.329728E7 2420000.0 1.36 1.228912E7 1989073.4693878 1.16793393562127 2.0488 0.9931 1965301 CMLD1_000269 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NS(=O)(=O)c2cccc3cccnc23)c4ccc(Cl)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M18 compound treatment 1.293132E7 1580000.0 0.88 1.04348E7 -444000.0 -0.25 1.04116E7 111553.4693878 0.0655013927536821 0.4043 0.4387 1965302 CMLD1_000270 COC(=O)[C@@]1(Cc2ccccc2)[C@H]3[C@H](CC(=O)C(=O)N(C)C)C(=O)C[C@H]3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M19 compound treatment 1.319788E7 1840000.0 1.03 1.226236E7 1380000.0 0.78 1.154484E7 1244793.4693878 0.730911430931312 1.4689 0.9879 1965303 CMLD1_000271 CCCC=C(CCC)[C@@H](NC(=O)Oc1ccc(F)cc1)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M20 compound treatment 1.231016E7 954000.0 0.54 1.195392E7 1080000.0 0.61 1.1122E7 821953.4693878 0.482630413191884 0.9374 0.9957 1965304 CMLD1_000272 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(C)c(F)c6F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M21 mock treatment 1.25374E7 1180000.0 0.66 1.17614E7 883000.0 0.5 1.132012E7 1020073.4693878 0.598961496425579 1.0157 0.9932 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M22 mock treatment 1.11422E7 -214000.0 -0.12 9991520.0 -887000.0 -0.5 9451840.0 -848206.530612201 -0.498045550736984 -0.6453 -0.9019 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M23 mock treatment 1.159792E7 242000.0 0.14 1.076116E7 -118000.0 -0.07 1.00298E7 -270246.530612201 -0.158681968737458 -0.0515 -0.2348 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 M24 mock treatment 1.139808E7 41900.0 0.02 1.058408E7 -295000.0 -0.17 9929240.0 -370806.530612201 -0.217728272644081 -0.2079 -0.7567 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N01 compound treatment 1.509692E7 3740000.0 2.1 1.306568E7 2190000.0 1.23 1.193812E7 1638073.4693878 0.961835559813542 2.4791 0.9469 1965305 CMLD1_000273 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCN6CNCC6=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N02 compound treatment 1.290288E7 1550000.0 0.87 1.320272E7 2320000.0 1.31 1.12886E7 988553.4693878 0.580453744843073 1.592 0.9509 1965306 CMLD1_000274 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N03 compound treatment 1.31544E7 1800000.0 1.01 1.683096E7 5950000.0 3.35 1.66526E7 6352553.4693878 3.73005969308423 4.6711 0.9133 1965307 CMLD1_000275 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(C)o6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N04 compound treatment 1.289084E7 1530000.0 0.86 1.743832E7 6560000.0 3.69 1.459892E7 4298873.4693878 2.52419042690528 4.0868 0.8972 1965308 CMLD1_000276 COC(=O)c1ccc(C#CC(NP(=O)(c2ccccc2)c3ccccc3)c4ccccc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N05 compound treatment 1.261888E7 1260000.0 0.71 1.587888E7 5000000.0 2.81 1.333792E7 3037873.4693878 1.78376292863307 3.0643 0.8995 1965309 CMLD1_000277 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(C)c(F)c7F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N06 compound treatment 1.2835E7 1480000.0 0.83 1.686588E7 5990000.0 3.37 1.46754E7 4375353.4693878 2.56909756018669 3.9086 0.9051 1965310 CMLD1_000278 O=P(NCC1(CC2(CO2)c3ccccc3)CC1)(c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N07 compound treatment 1.301528E7 1660000.0 0.93 1.585716E7 4980000.0 2.8 1.572688E7 5426833.4693878 3.18650018182289 3.9957 0.9197 1965311 CMLD1_000279 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5C[C@H](O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N08 compound treatment 1.074344E7 -613000.0 -0.34 1.050608E7 -373000.0 -0.21 1.124404E7 943993.4693878 0.554289233088109 2.0E-4 3.0E-4 1965312 CMLD1_000280 CCCCCC1=C2CNC(CCC)(C=C2C(C)C1=O)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N09 compound treatment 1.288E7 1520000.0 0.86 1.262872E7 1750000.0 0.99 1.234076E7 2040713.4693878 1.19825564538398 1.7547 0.9904 1965313 CMLD1_000281 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCN7CCOCC7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N10 compound treatment 1.292372E7 1570000.0 0.88 1.191252E7 1030000.0 0.58 1.141432E7 1114273.4693878 0.65427336822355 1.222 0.9841 1965314 CMLD1_000282 CCCCCC1=C2CNC(CC(C)C)(C=C2C(C)C1=O)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N11 compound treatment 6675120.0 -4680000.0 -2.63 6986120.0 -3890000.0 -2.19 6833840.0 -3466206.5306122 -2.03526933382709 -3.9582 -0.994 1965315 CMLD1_000283 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cc(C)n(C)n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N12 compound treatment 1.359716E7 2240000.0 1.26 1.54246E7 4550000.0 2.56 1.476632E7 4466273.4693878 2.62248349844435 3.7182 0.9597 1965316 CMLD1_000284 COC1OC[C@]2(C)[C@@H]3[C@H]1CCC4C(CO)C(CO)[C@@H](C)C(=C43)CN2C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N13 compound treatment 1.511484E7 3760000.0 2.11 1.448184E7 3600000.0 2.03 1.231916E7 2019113.4693878 1.18557266841119 3.0744 0.9734 1965317 CMLD1_000285 COC(=O)Cn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccccc5)C(=O)OC)Cc21)C(=O)N6CCCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N14 compound treatment 1.376256E7 2410000.0 1.35 1.83828E7 7500000.0 4.22 1.353304E7 3232993.4693878 1.89833248728722 4.3151 0.8945 1965318 CMLD1_000286 CC[C@@H]1C(COC)C(COC)C2CC[C@H]3C(OCc4ccc(F)cc4C(F)(F)F)OC[C@]5(C)[C@H]3C2=C1CN5C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N15 compound treatment 1.301284E7 1660000.0 0.93 1.36146E7 2740000.0 1.54 1.223632E7 1936273.4693878 1.13693110302113 2.0828 0.9786 1965319 CMLD1_000287 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6c(O)c(C)cnc6CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N16 compound treatment 1.380136E7 2450000.0 1.37 1.299636E7 2120000.0 1.19 1.246196E7 2161913.4693878 1.26942123839793 2.214 0.9983 1965320 CMLD1_000288 CC1(C)C(=O)C(=C2CN3C(=O)N(CCc4ccccc4)C(=O)C3(Cc5ccccc5)C=C21)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N17 compound treatment 1.28836E7 1530000.0 0.86 1.09398E7 61000.0 0.03 1.082584E7 525793.4693878 0.308732706698391 0.6934 0.7599 1965321 CMLD1_000289 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5[nH]c(cc35)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N18 compound treatment 1.371332E7 2360000.0 1.32 1.253948E7 1660000.0 0.93 1.226568E7 1965633.4693878 1.15417055690636 1.9705 0.9903 1965322 CMLD1_000290 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5[nH]c(cc35)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N19 compound treatment 1.32054E7 1850000.0 1.04 1.06134E7 -265000.0 -0.15 1.093536E7 635313.4693878 0.37304009734928 0.7288 0.6544 1965323 CMLD1_000291 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7c[nH]c8ccc(O)cc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N20 compound treatment 1.29274E7 1570000.0 0.88 1.252952E7 1650000.0 0.93 1.131936E7 1019313.4693878 0.598515243532092 1.3916 0.9839 1965324 CMLD1_000292 COCCn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(F)cc5)C(=O)OC)Cc21)C(=O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N21 mock treatment 1.4701E7 3340000.0 1.88 1.530908E7 4430000.0 2.49 1.19076E7 1607553.4693878 0.943914983090887 3.0695 0.941 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N22 mock treatment 1.261344E7 1260000.0 0.71 1.191844E7 1040000.0 0.59 1.14274E7 1127353.4693878 0.661953615390402 1.1278 0.9971 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N23 mock treatment 364360.0 -1.1E7 -6.17 468200.0 -1.04E7 -5.86 517120.0 -9782926.5306122 -5.74428851454556 -10.2644 -0.9995 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 N24 mock treatment 1.307932E7 1720000.0 0.97 1.184084E7 962000.0 0.54 1.066592E7 365873.4693878 0.214831703111007 0.9955 0.8812 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O01 compound treatment 1.438148E7 3030000.0 1.7 1.361224E7 2730000.0 1.54 1.090996E7 609913.4693878 0.358125855909063 2.0762 0.8948 1965325 CMLD1_000293 CCCC=C(CCC)[C@@H](NC(=O)OCC(C)C)c1ccc(cc1)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O02 compound treatment 1.1785E7 429000.0 0.24 1.349104E7 2610000.0 1.47 1.60028E7 5702753.4693878 3.348513469153 2.9213 0.7971 1965326 CMLD1_000294 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O03 compound treatment 1.304344E7 1690000.0 0.95 1.345528E7 2580000.0 1.45 1.522028E7 4920233.4693878 2.88903739782234 3.0525 0.9061 1965327 CMLD1_000295 CCCC=C(CCC)[C@@H](NP(=O)(c1ccccc1)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O04 compound treatment 1.269032E7 1330000.0 0.75 1.214452E7 1270000.0 0.71 1.170952E7 1409473.4693878 0.827607386851587 1.3218 0.998 1965268 CMLD1_000296 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(O)c(OC)c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O05 compound treatment 1.221832E7 862000.0 0.48 1.224708E7 1370000.0 0.77 1.175004E7 1449993.4693878 0.851399712172752 1.2158 0.9758 1965328 CMLD1_000297 CCCC=C(CCC)[C@@H](NS(=O)(=O)c1cccs1)c2ccc(cc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O06 compound treatment 1.212072E7 765000.0 0.43 1.319252E7 2310000.0 1.3 1.206396E7 1763913.4693878 1.0357256441772 1.5979 0.9298 1965329 CMLD1_000298 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7cccc8ccccc78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O07 compound treatment 1.172772E7 372000.0 0.21 1.239248E7 1510000.0 0.85 1.257756E7 2277513.4693878 1.33729865219671 1.3845 0.8657 1965330 CMLD1_000299 CCCCC=C[C@@H](NC(=O)c1cccs1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O08 compound treatment 1.3136E7 1780000.0 1.0 1.253024E7 1650000.0 0.93 1.210956E7 1809513.4693878 1.06250081778641 1.7273 0.9985 1965331 CMLD1_000300 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCF 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O09 compound treatment 1.294244E7 1590000.0 0.89 1.502744E7 4150000.0 2.34 1.17668E7 1466753.4693878 0.861240762823856 2.3599 0.8927 1965332 CMLD1_000301 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccc(cc2)C(F)(F)F)c3ccc(cc3)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O10 compound treatment 1.297056E7 1610000.0 0.91 1.469988E7 3820000.0 2.15 1.271344E7 2413393.4693878 1.41708397215328 2.5835 0.9461 1965333 CMLD1_000302 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]3[C@H](CC(=O)C(=O)N(C)C)C(=O)C[C@H]3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O11 compound treatment 1.302116E7 1670000.0 0.94 1.282324E7 1940000.0 1.09 1.201256E7 1712513.4693878 1.00554485638086 1.7524 0.9979 1965334 CMLD1_000303 CCCC=C(CCC)[C@@H](NC(=O)c1ccccc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O12 compound treatment 1.362556E7 2270000.0 1.27 1.29328E7 2050000.0 1.16 1.277852E7 2478473.4693878 1.45529731203238 2.2437 0.9955 1965335 CMLD1_000304 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCc7ccc(OC)c(Br)c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O13 compound treatment 1.138872E7 32600.0 0.02 1.038076E7 -498000.0 -0.28 1.026244E7 -37606.5306122005 -0.0220816093417039 -0.1641 -0.5821 1965336 CMLD1_000305 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)Cc2ccccc2)c3ccc(cc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O14 compound treatment 1.169276E7 337000.0 0.19 1.218712E7 1310000.0 0.74 1.168704E7 1386993.4693878 0.814407696002135 1.0046 0.9016 1965337 CMLD1_000306 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccsc7Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O15 compound treatment 1.23952E7 1040000.0 0.58 1.274504E7 1870000.0 1.05 1.194012E7 1640073.4693878 0.963009909533244 1.4995 0.9737 1965338 CMLD1_000307 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c2ccccc2)c3ccc(cc3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O16 compound treatment 1.242792E7 1070000.0 0.6 1.306084E7 2180000.0 1.23 1.243112E7 2131073.4693878 1.25131276572012 1.7792 0.9597 1965339 CMLD1_000308 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6nc7ccccc7[nH]6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O17 compound treatment 1.242424E7 1070000.0 0.6 1.31476E7 2270000.0 1.28 1.22028E7 1902753.4693878 1.11724900171892 1.7288 0.9605 1965340 CMLD1_000309 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NC(=O)c2ccco2)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O18 compound treatment 1.29632E7 1610000.0 0.9 1.229996E7 1420000.0 0.8 1.232192E7 2021873.4693878 1.18719327102438 1.6684 0.9859 1965341 CMLD1_000310 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCSCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O19 compound treatment 1.277592E7 1420000.0 0.8 1.196236E7 1080000.0 0.61 1.09952E7 695153.4693878 0.408176640962768 1.0482 0.9672 1965342 CMLD1_000311 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NC(=O)c2cccs2)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O20 compound treatment 1.198896E7 633000.0 0.36 1.22698E7 1390000.0 0.78 1.151548E7 1215433.4693878 0.713671977046085 1.0693 0.9569 1965343 CMLD1_000312 COC(=O)[C@@]1(Cc2ccccc2)[C@H]3[C@H](CC(=O)C(=O)N(C)C)C(=O)C=C3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O21 mock treatment 1.064852E7 -708000.0 -0.4 8569640.0 -2310000.0 -1.3 9860920.0 -439126.530612201 -0.257844059069107 -1.1288 -0.8159 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O22 mock treatment 1.123244E7 -124000.0 -0.07 1.098856E7 110000.0 0.06 1.0715E7 414953.4693878 0.243650245232498 0.1362 0.5223 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O23 mock treatment 1.06142E7 -742000.0 -0.42 1.054576E7 -333000.0 -0.19 1.00358E7 -264246.530612201 -0.155158919578351 -0.4384 -0.9085 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 O24 mock treatment 8947400.0 -2410000.0 -1.35 9146640.0 -1730000.0 -0.98 8529560.0 -1770486.5306122 -1.03958518048043 -1.9443 -0.9894 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P01 compound treatment 9874760.0 -1480000.0 -0.83 1.028884E7 -590000.0 -0.33 9813760.0 -486286.530612201 -0.285535225459683 -0.837 -0.8901 1965344 CMLD1_000313 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6ccc(cc6)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P02 compound treatment 1.11116E7 -245000.0 -0.14 1.22254E7 1350000.0 0.76 1.066456E7 364513.4693878 0.21403314530161 0.4819 0.6027 1965345 CMLD1_000314 COC(=O)Cn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(F)cc5)C(=O)OC)Cc21)C(=O)N6CCCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P03 compound treatment 1.157336E7 217000.0 0.12 1.201284E7 1130000.0 0.64 1.113728E7 837233.4693878 0.491602445050409 0.7228 0.887 1965346 CMLD1_000315 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCc6c[nH]c7ccc(O)cc67 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P04 compound treatment 1.088796E7 -468000.0 -0.26 1.189836E7 1020000.0 0.57 1.124716E7 947113.4693878 0.556121218650845 0.5006 0.595 1965347 CMLD1_000316 COC(=O)c1ccc(cc1)C23CC3(C2)C(NP(=O)(c4ccccc4)c5ccccc5)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P05 compound treatment 1.199484E7 639000.0 0.36 1.277596E7 1900000.0 1.07 1.197656E7 1676513.4693878 0.984406561426217 1.392 0.9305 1965348 CMLD1_000317 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7ccc(Cl)c(c7)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P06 compound treatment 1.204872E7 693000.0 0.39 1.201308E7 1130000.0 0.64 1.134812E7 1048073.4693878 0.615402392501409 0.9485 0.9795 1965349 CMLD1_000318 COCC1[C@@H](C)C2=C3C(CC[C@H]4C(OCc5ccc(F)cc5C(F)(F)F)OC[C@](C)([C@H]43)N(C2)C(=O)OC(C)(C)C)C1COC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P07 compound treatment 251520.0 -1.11E7 -6.24 372560.0 -1.05E7 -5.91 441120.0 -9858926.5306122 -5.78891380389424 -10.3578 -0.9995 1965350 CMLD1_000319 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5Cc7c(O)c(C)cnc7CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P08 compound treatment 1.070128E7 -655000.0 -0.37 1.232696E7 1450000.0 0.82 1.217128E7 1871233.4693878 1.09874125013642 0.8926 0.6301 1965351 CMLD1_000320 COC(=O)C1(Cc2ccccc2)NCC3=C(C)C(=O)C(C)C3=C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P09 compound treatment 1.422996E7 2870000.0 1.61 1.241084E7 1530000.0 0.86 1.205428E7 1754233.4693878 1.03004179153384 2.0245 0.964 1965352 CMLD1_000321 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N6CCCC6)n5CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P10 compound treatment 1.237848E7 1020000.0 0.57 1.215992E7 1280000.0 0.72 1.216488E7 1864833.4693878 1.09498333103337 1.3801 0.9642 1965353 CMLD1_000322 CCCc1cc2C3C(CN(C(=O)c4ccccc4)C3(C)C(=O)OC)C(C)c2n1Cc5ccc(C)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P11 compound treatment 330160.0 -1.1E7 -6.19 648720.0 -1.02E7 -5.76 532520.0 -9767526.5306122 -5.73524602170386 -10.2116 -0.9994 1965354 CMLD1_000323 COCCn1c(cc2[C@H]3[C@H](CN(C(=O)c4ccccc4)[C@@]3(Cc5ccc(OC)cc5)C(=O)OC)Cc21)C(=O)N6CCCC6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P12 compound treatment 1.249788E7 1140000.0 0.64 1.292772E7 2050000.0 1.15 1.104948E7 749433.4693878 0.440048492355485 1.2902 0.9275 1965355 CMLD1_000324 CC[C@@H]1C(CO)C(CO)C2CC[C@H]3C(OC)OC[C@]4(C)[C@H]3C2=C1CN4C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P13 compound treatment 1.236648E7 1010000.0 0.57 1.190216E7 1020000.0 0.58 1.191112E7 1611073.4693878 0.945981838597563 1.2064 0.9694 1965356 CMLD1_000325 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6c(O)c(C)cnc6OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P14 compound treatment 1.190912E7 553000.0 0.31 1.234548E7 1470000.0 0.83 1.208592E7 1785873.4693878 1.04862000409953 1.2614 0.9205 1965357 CMLD1_000326 COCC1[C@@H](C)C2=C3C(CC[C@H]4C(OCc5ccc(OC)cc5)OC[C@](C)([C@H]43)N(C2)C(=O)OC(C)(C)C)C1COC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P15 compound treatment 1.234284E7 987000.0 0.55 1.165108E7 772000.0 0.43 1.169292E7 1392873.4693878 0.817860284178059 1.0431 0.9664 1965358 CMLD1_000327 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCn6cc(nc6C)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P16 compound treatment 1.21766E7 820000.0 0.46 1.26784E7 1800000.0 1.01 1.198712E7 1687073.4693878 0.990607127946245 1.4228 0.955 1965359 CMLD1_000328 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6cc(F)cc7COCOc67 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P17 compound treatment 1.143156E7 75400.0 0.04 1.164076E7 762000.0 0.43 1.063752E7 337473.4693878 0.198155937091237 0.3865 0.8147 1965360 CMLD1_000329 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@H]3C(=C)C(=O)C=C3CN1C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P18 compound treatment 1.21286E7 772000.0 0.43 1.186864E7 990000.0 0.56 1.117132E7 871273.4693878 0.511589877279739 0.8676 0.9949 1965361 CMLD1_000330 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P19 compound treatment 1.124968E7 -106000.0 -0.06 1.0529E7 -350000.0 -0.2 1.014628E7 -153766.530612201 -0.0902878410620046 -0.2003 -0.8915 1965362 CMLD1_000331 COC(=O)[C@@]1(Cc2ccccc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5Cc6nc7ccccc7[nH]6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P20 compound treatment 1.101904E7 -337000.0 -0.19 7611720.0 -3270000.0 -1.84 6992720.0 -3307326.5306122 -1.94197899209395 -2.2923 -0.8549 1965363 CMLD1_000332 COC(=O)[C@@]1(Cc2ccc(F)cc2)[C@@H]3[C@H](CN1C(=O)c4ccccc4)Cc5c3cc(C(=O)N(C)C)n5CCF 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P21 mock treatment 1.023284E7 -1120000.0 -0.63 9080360.0 -1800000.0 -1.01 8488280.0 -1811766.5306122 -1.06382375869508 -1.563 -0.9779 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P22 mock treatment 1.04784E7 -878000.0 -0.49 1.079404E7 -84800.0 -0.05 9988480.0 -311566.530612201 -0.182944033946504 -0.4178 -0.7913 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P23 mock treatment 9885840.0 -1470000.0 -0.83 9673280.0 -1210000.0 -0.68 8799240.0 -1500806.5306122 -0.881235864275794 -1.3774 -0.9943 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1462 P24 mock treatment 8961720.0 -2390000.0 -1.34 8649000.0 -2230000.0 -1.26 7614880.0 -2685166.5306122 -1.57666228128901 -2.4115 -0.9953 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A01 compound treatment 7610560.0 -3350000.0 -1.88 8415520.0 -3620000.0 -2.04 9195400.0 -2984849.0322581 -1.75262831219276 -3.2763 -0.9981 2065621 ICCB6_000001 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccccc4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A02 compound treatment 1.003864E7 -925000.0 -0.52 1.117272E7 -865000.0 -0.49 9493320.0 -2686929.0322581 -1.57769717794593 -1.4918 -0.8619 2065622 ICCB6_000002 OCCCCCCCCCc1ccc(C=O)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A03 compound treatment 1.07112E7 -252000.0 -0.14 1.071088E7 -1330000.0 -0.75 1.176592E7 -414329.032258101 -0.243283591448381 -0.6534 -0.8188 2065623 ICCB6_000003 CC1(C)OC(=O)C=C(CC(O)c2ccccc2)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A04 compound treatment 1.115364E7 190000.0 0.11 1.173832E7 -299000.0 -0.17 1.206696E7 -113289.032258101 -0.066520471638814 -0.074 -0.3519 2065624 ICCB6_000004 CO[C@H]1O[C@H](CO)[C@@H](OCc2ccccc2)[C@H](OCc3ccccc3)[C@@H]1OCCCc4ccc(C=O)o4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A05 compound treatment 1.15026E7 539000.0 0.3 1.229408E7 257000.0 0.14 1.227552E7 95270.9677418992 0.0559407171317258 0.2905 0.8542 2065625 ICCB6_000005 Clc1ccccc1C(CC(=O)c2ccccc2)C(=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A06 compound treatment 1.16602E7 697000.0 0.39 1.26158E7 578000.0 0.33 1.304736E7 867110.967741899 0.509145760959178 0.7078 0.9832 2065626 ICCB6_000006 OCCCCCCCCCCc1ccc(C=O)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A07 compound treatment 1.081712E7 -146000.0 -0.08 1.159704E7 -440000.0 -0.25 1.185832E7 -321929.032258101 -0.189028634398142 -0.2997 -0.9297 2065627 ICCB6_000007 CCOC(=O)CC1[C@@H]2[C@@H](NCc3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C)N1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A08 compound treatment 1.153788E7 574000.0 0.32 1.205808E7 20700.0 0.01 1.22906E7 110350.967741899 0.0647953140182799 0.2304 0.6997 2065628 ICCB6_000008 OC[C@H](COCCCc1ccc(C=O)o1)OCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A09 compound treatment 1.074924E7 -214000.0 -0.12 1.194396E7 -93400.0 -0.05 1.166648E7 -513769.032258101 -0.301672259511972 -0.274 -0.8329 2065629 ICCB6_000009 CCOC(=O)CC1[C@@H]2[C@@H](NCc3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C(C)C)N1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A10 compound treatment 1.165252E7 689000.0 0.39 1.263132E7 594000.0 0.33 1.304128E7 861030.967741899 0.505575737811283 0.7083 0.985 2065630 ICCB6_000010 OCCOCCCc1ccc(C=O)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A11 compound treatment 1.08862E7 -77300.0 -0.04 1.212752E7 90100.0 0.05 1.21438E7 -36449.0322581008 -0.0214019554078576 -0.0082 -0.1162 2065631 ICCB6_000011 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](Cc5ccccc5)N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A12 compound treatment 1.138732E7 424000.0 0.24 1.182236E7 -215000.0 -0.12 1.232432E7 144070.967741899 0.0845948502924581 0.1164 0.4155 2065632 ICCB6_000012 OCc1ccc(CCc2ccc(C=O)o2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A13 compound treatment 1.137588E7 412000.0 0.23 1.246164E7 424000.0 0.24 1.265324E7 472990.967741899 0.277728405194673 0.4319 0.9967 2065633 ICCB6_000013 CCOC(=O)CC(C#N)(C(=O)OCC)c1nsc2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A14 compound treatment 9844120.0 -1120000.0 -0.63 1.225336E7 216000.0 0.12 1.243768E7 257430.967741899 0.151156992405176 -0.2056 -0.3124 2065634 ICCB6_000014 OCCOCCOCCCc1ccc(C=O)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A15 compound treatment 1.1106E7 142000.0 0.08 1.19728E7 -64600.0 -0.04 1.232492E7 144670.967741899 0.0849471552083688 0.0742 0.6074 ICCB6_000015 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A16 compound treatment 1.133152E7 368000.0 0.21 1.236596E7 329000.0 0.18 1.334376E7 1163510.9677419 0.683184389419036 0.6205 0.8416 2065635 ICCB6_000016 OCC1CC2CCN1CC2CCc3ccc(C=O)o3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A17 compound treatment 1.091972E7 -43800.0 -0.02 1.212976E7 92400.0 0.05 1.246164E7 281390.967741899 0.165225702047207 0.1112 0.6356 1952805 ICCB6_000017 CC(C)(C)[Si](C)(C)OCCNC(=O)c1cc(cc2c(coc12)C(O)(c3ccccc3)c4ccccc4)c5cc(I)cc(I)c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A18 compound treatment 1.127036E7 307000.0 0.17 1.201932E7 -18100.0 -0.01 1.224644E7 66190.9677418992 0.0388656722072566 0.1161 0.6559 2065636 ICCB6_000018 OCCCCNC(=O)OCCCc1ccc(C=O)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A19 compound treatment 1.070892E7 -255000.0 -0.14 1.197648E7 -60900.0 -0.03 1.236212E7 181870.967741899 0.106790059994829 -0.0407 -0.224 1952839 ICCB6_000019 Oc1ccccc1C#CC#Cc2ccccc2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A20 compound treatment 8304440.0 -2660000.0 -1.49 1.144716E7 -590000.0 -0.33 1.186044E7 -319809.032258101 -0.187783823695258 -1.1626 -0.7541 2065637 ICCB6_000020 OCCCCc1ccc(C=O)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A21 compound treatment 2146600.0 -8820000.0 -4.95 1957840.0 -1.01E7 -5.67 6626400.0 -5553849.0322581 -3.26108052715017 -8.0178 -0.977 1952635 ICCB6_000021 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCC(c3ccccc3)c4ccccc4)O2)O1)OC(=O)NCc5ccc6OCOc6c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A22 compound treatment 8951600.0 -2010000.0 -1.13 9911120.0 -2130000.0 -1.2 1.108544E7 -1094809.0322581 -0.642844340079839 -1.7146 -0.9703 2065638 ICCB6_000022 OCCCCCCc1ccc(/C=C/COC(=O)Nc2ccccc2)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A23 mock treatment 9572360.0 -1390000.0 -0.78 1.042368E7 -1610000.0 -0.91 1.040712E7 -1773129.0322581 -1.04113679101402 -1.5767 -0.9933 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 A24 mock treatment 8293040.0 -2670000.0 -1.5 8739000.0 -3300000.0 -1.86 1.001292E7 -2167329.0322581 -1.27260112076731 -2.6727 -0.9881 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B01 compound treatment 1.06636E7 -300000.0 -0.17 1.093264E7 -1100000.0 -0.62 1.151668E7 -663569.032258101 -0.389631053517662 -0.6813 -0.9048 2065621 ICCB6_000023 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccccc4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B02 compound treatment 1.138288E7 419000.0 0.24 1.150092E7 -536000.0 -0.3 1.234364E7 163390.967741899 0.0959390685847809 0.017 0.0431 2065639 ICCB6_000024 OB1OC(COCc2ccccc2)CC=C1C(=C)CCCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B03 compound treatment 1.23004E7 1340000.0 0.75 1.337592E7 1340000.0 0.75 1.258264E7 402390.967741899 0.236273860089187 1.0049 0.9223 2065640 ICCB6_000025 CC1(C)OC(=O)C=C(CC(O)C2CCCCC2)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B04 compound treatment 1.167572E7 712000.0 0.4 1.273136E7 694000.0 0.39 1.2983E7 802750.967741899 0.471355186979163 0.7286 0.9963 2065641 ICCB6_000026 CC(C)C(=C)C1=CCC(COCc2ccccc2)OB1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B05 compound treatment 1.152096E7 557000.0 0.31 1.244976E7 412000.0 0.23 1.24168E7 236550.967741899 0.138896781331485 0.395 0.9546 2065642 ICCB6_000027 C[Si](C)(C(NP(=O)(c1ccccc1)c2ccccc2)c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B06 compound treatment 1.23144E7 1350000.0 0.76 1.331452E7 1280000.0 0.72 1.298848E7 808230.967741899 0.474572905211147 1.1271 0.9819 2065643 ICCB6_000028 CCCC(=C)C1=CCC(COCc2ccccc2)OB1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B07 compound treatment 1.187228E7 909000.0 0.51 1.367992E7 1640000.0 0.92 1.27768E7 596550.967741899 0.350279730877872 1.0307 0.9263 2065644 ICCB6_000029 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C)N1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B08 compound treatment 1.2776E7 1810000.0 1.02 1.445872E7 2420000.0 1.36 1.33714E7 1191150.9677419 0.69941390254532 1.7785 0.9669 2065645 ICCB6_000030 O[C@@H]([C@H](Oc1ccccc1)C=C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B09 compound treatment 1.200976E7 1050000.0 0.59 1.360056E7 1560000.0 0.88 1.303796E7 857710.967741899 0.503626317276578 1.1381 0.9712 2065646 ICCB6_000031 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](C(C)C)N1C(=O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B10 compound treatment 1.278264E7 1820000.0 1.02 1.390644E7 1870000.0 1.05 1.353688E7 1356630.9677419 0.796579598353475 1.6572 0.993 2065647 ICCB6_000032 O[C@H](COCc1ccccc1)[C@H](Oc2ccccc2)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B11 compound treatment 1.045468E7 -509000.0 -0.29 1.271064E7 673000.0 0.38 1.245216E7 271910.967741899 0.159659284375819 0.146 0.2915 2065648 ICCB6_000033 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](Cc4ccccc4)N1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B12 compound treatment 1.179532E7 832000.0 0.47 1.22526E7 215000.0 0.12 1.179476E7 -385489.032258101 -0.226349468490276 0.209 0.392 2065649 ICCB6_000034 CC(C)C(=C)C(=O)CCC(COCc1ccccc1)OC(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B13 compound treatment 1.283224E7 1870000.0 1.05 1.462496E7 2590000.0 1.46 1.381488E7 1634630.9677419 0.959814209392074 2.0011 0.9829 2065650 ICCB6_000035 [O-][N+](=O)c1ccc(OS(=O)(=O)C(F)(F)F)c(I)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B14 compound treatment 1.215836E7 1190000.0 0.67 8415760.0 -3620000.0 -2.04 8949400.0 -3230849.0322581 -1.89707332771613 -1.8848 -0.658 2065651 ICCB6_000036 CCCC(=C=CC[C@@H](OC(=O)Nc1ccc(Br)cc1)c2ccccc2)CCOC(=O)Nc3ccc(Br)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B15 compound treatment 1.251948E7 1560000.0 0.87 1.401612E7 1980000.0 1.11 1.33944E7 1214150.9677419 0.712918924321894 1.5592 0.9837 1952458 ICCB6_000037 Fc1ccc(cc1Br)[C@@H]2C3=C(C[C@@H]4C2=CCn5n4c(=O)n(c6ccccc6)c5=O)C(=O)OC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B16 compound treatment 1.182396E7 860000.0 0.48 1.39302E7 1890000.0 1.07 1.305384E7 873590.967741899 0.512950654051013 1.1903 0.9318 2065652 ICCB6_000038 CC(C)C(=C=CC[C@H](COCc1ccccc1)OC(=O)c2ccc(Br)cc2)CCOC(=O)c3ccc(Br)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B17 compound treatment 1.189996E7 936000.0 0.53 1.3425E7 1390000.0 0.78 1.346564E7 1285390.9677419 0.754749261337685 1.1904 0.9864 1952808 ICCB6_000039 CCCCCc1cc2ccccc2o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B18 compound treatment 1.24852E7 1520000.0 0.85 1.372308E7 1690000.0 0.95 1.359544E7 1415190.9677419 0.830964558146354 1.521 0.9983 2065653 ICCB6_000040 CC1(C)OC[C@@H](C=C)[C@H](CCc2ccccc2)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B19 compound treatment 9459560.0 -1500000.0 -0.84 1.092396E7 -1110000.0 -0.63 1.062588E7 -1554369.0322581 -0.912686418672998 -1.3765 -0.9884 1952842 ICCB6_000041 COC(=O)Cc1cc(cc(I)c1O)c2cc(F)cc(I)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B20 compound treatment 1.144636E7 483000.0 0.27 1.347356E7 1440000.0 0.81 1.36076E7 1427350.9677419 0.838104604442143 1.1072 0.926 2065654 ICCB6_000042 CCC[C@@]1(CCO[Si](c2ccccc2)(c3ccccc3)C(C)(C)C)O[C@@H](Cc4ccccc4)CC=C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B21 compound treatment 350720.0 -1.06E7 -5.96 444840.0 -1.16E7 -6.53 3151040.0 -9029209.0322581 -5.30172454808219 -10.2701 -0.9965 1952636 ICCB6_000043 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCCc3ccc(Cl)cc3)O2)O1)OC(=O)NCc4ccc5OCOc5c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B22 compound treatment 1.03472E7 -616000.0 -0.35 1.151372E7 -524000.0 -0.29 1.19552E7 -225049.032258101 -0.13214313397577 -0.4464 -0.9427 3056822 ICCB6_000044 CC(C)[Si](OC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)c4ccccc4C3=O)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B23 mock treatment 1.074316E7 -220000.0 -0.12 1.184872E7 -189000.0 -0.11 1.256076E7 380510.967741899 0.223426474155646 -0.0038 -0.0137 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 B24 mock treatment 9986520.0 -977000.0 -0.55 1.06892E7 -1350000.0 -0.76 1.130164E7 -878609.032258101 -0.515897135380037 -1.0529 -0.9847 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C01 compound treatment 1.094044E7 -23100.0 -0.01 1.207176E7 34400.0 0.02 1.123744E7 -942809.032258101 -0.553593761382476 -0.3159 -0.5702 2065655 ICCB6_000045 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccc(C)cc4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C02 compound treatment 1.0767E7 -197000.0 -0.11 1.254192E7 505000.0 0.28 1.233276E7 152510.967741899 0.0895506061096012 0.1519 0.4784 2065656 ICCB6_000046 C[C@@H]([C@H](O)c1ccc(CCCCCCO)o1)C(=O)N2[C@@H](C)[C@H](OC2=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C03 compound treatment 1.203892E7 1080000.0 0.6 1.332616E7 1290000.0 0.73 1.276124E7 580990.967741899 0.341143290058589 0.9645 0.9609 2065657 ICCB6_000047 COC(=O)c1cn2c(c1C(=O)OC)c(=O)n(C)c3ccccc32 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C04 compound treatment 1.21056E7 1140000.0 0.64 1.349384E7 1460000.0 0.82 1.291916E7 738910.967741899 0.43386994392627 1.0942 0.9702 2065658 ICCB6_000048 C[C@@H]([C@H](O)c1ccc(CCCCCCO)o1)C(=O)N2[C@H](COC2=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C05 compound treatment 1.046004E7 -504000.0 -0.28 1.107744E7 -960000.0 -0.54 1.171848E7 -461769.032258101 -0.271139166799716 -0.6318 -0.9466 2065659 ICCB6_000049 C[Si](C)(C(NP(=O)(c1ccccc1)c2ccccc2)c3ccccc3Cl)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C06 compound treatment 1.182568E7 862000.0 0.48 1.255416E7 517000.0 0.29 1.335736E7 1177110.9677419 0.691169967513011 0.8466 0.9484 2065660 ICCB6_000050 CC(C)[C@H]1COC(=O)N1C(=O)[C@@H](C)[C@H](O)c2ccc(CCCCCCO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C07 compound treatment 1.312752E7 2160000.0 1.22 1.309568E7 1060000.0 0.6 1.281752E7 637270.967741899 0.374189491171007 1.2617 0.8984 2065661 ICCB6_000051 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](C)N1C(=O)CCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C08 compound treatment 1.164908E7 686000.0 0.39 1.251308E7 476000.0 0.27 1.156664E7 -613609.032258101 -0.360295797519503 0.1689 0.2856 2065662 ICCB6_000052 CC(C)[C@@H]1N(C(=O)[C@@H](C)[C@H](O)c2ccc(CCCCCCO)o2)C(=O)OC1(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C09 compound treatment 1.221452E7 1250000.0 0.7 1.340692E7 1370000.0 0.77 1.313612E7 955870.967741899 0.561263401519559 1.1748 0.9918 2065663 ICCB6_000053 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](CC(C)C)N1C(=O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C10 compound treatment 1.157724E7 614000.0 0.34 1.232772E7 290000.0 0.16 1.188944E7 -290809.032258101 -0.170755752759577 0.1948 0.466 2065664 ICCB6_000054 COC(=O)[C@H](Cc1ccccc1)NC(=O)OC/C=C/c2ccc(CCCCCCO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C11 compound treatment 1.123556E7 272000.0 0.15 1.30048E7 967000.0 0.54 1.255992E7 379670.967741899 0.222933247273371 0.5313 0.874 2065665 ICCB6_000055 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](Cc4ccccc4)N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C12 compound treatment 1.238772E7 1420000.0 0.8 1.208144E7 44000.0 0.02 1.203388E7 -146369.032258101 -0.0859442160026875 0.4265 0.5299 2065666 ICCB6_000056 CCc1cccc(NC(=O)OC/C=C/c2ccc(CCCCCCO)o2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C13 compound treatment 8935160.0 -2030000.0 -1.14 1.018456E7 -1850000.0 -1.04 9287160.0 -2893089.0322581 -1.69874914705283 -2.2407 -0.9759 1065064 ICCB6_000057 [O-][N+](=O)c1ccc(CBr)c(I)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C14 compound treatment 1.17074E7 744000.0 0.42 1.307428E7 1040000.0 0.58 1.290896E7 728710.967741899 0.427880760355789 0.8252 0.9875 2065667 ICCB6_000058 OCCCCCCc1ccc(/C=C/COC(=O)Nc2ccc(Oc3ccccc3)cc2)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C15 compound treatment 1.202604E7 1060000.0 0.6 1.301584E7 978000.0 0.55 1.311128E7 931030.967741899 0.546677978000859 0.9782 0.9992 1952482 ICCB6_000059 Fc1ccc(cc1Br)[C@H]2C3=CC[C@H]4[C@@H]([C@@H]3C[C@@]5(C#N)C(=O)C(=C(Cl)C(=O)[C@@]25C#N)Cl)C(=O)N(C4=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C16 compound treatment 1.127312E7 310000.0 0.17 1.240912E7 372000.0 0.21 1.23428E7 162550.967741899 0.0954458417025059 0.2763 0.9583 2065668 ICCB6_000060 COc1cccc(C)c1NC(=O)OC/C=C/c2ccc(CCCCCCO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C17 compound treatment 1.237244E7 1410000.0 0.79 1.429508E7 2260000.0 1.27 1.37086E7 1528350.9677419 0.897409265287102 1.7087 0.979 1952809 ICCB6_000061 CC(=O)Oc1ccccc1C#Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C18 compound treatment 1.220604E7 1240000.0 0.7 1.305524E7 1020000.0 0.57 1.28902E7 709950.967741899 0.416865359984983 0.9744 0.9798 2065669 ICCB6_000062 OCCCCCCc1ccc(/C=C/COC(=O)Nc2ccc(C#N)cc2)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C19 compound treatment 1.218588E7 1220000.0 0.69 1.382472E7 1790000.0 1.01 1.414028E7 1960030.9677419 1.15088090878761 1.6417 0.9797 1952773 ICCB6_000063 CCCNC(=O)c1cc(cc2c3C(=O)OC4(CCCC4)c3oc12)c5cc(F)cc(F)c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C20 compound treatment 1.129344E7 330000.0 0.19 1.291204E7 875000.0 0.49 1.280528E7 625030.967741899 0.36700247088643 0.6031 0.9403 2065670 ICCB6_000064 CCOC(=O)CNC(=O)OC/C=C/c1ccc(CCCCCCO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C21 compound treatment 759920.0 -1.02E7 -5.73 1621880.0 -1.04E7 -5.86 905160.0 -1.12750890322581E7 -6.62044882232452 -10.5162 -0.9979 1952585 ICCB6_000065 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)CC[C@@H]2C[C@H](C[C@@]3(CCC[C@H](COC(=O)NCCCN4CCCC4=O)O3)O2)OC(=O)NCc5cccc6ccccc56 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C22 compound treatment 1.056664E7 -397000.0 -0.22 1.177352E7 -264000.0 -0.15 1.143156E7 -748689.032258101 -0.439611377588186 -0.4683 -0.9096 2065671 ICCB6_000066 OCCCCCCc1ccc(/C=C/COC(=O)Nc2ccccc2F)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C23 mock treatment 1.096944E7 5900.0 0.0 1.2483E7 446000.0 0.25 1.245292E7 272670.967741899 0.160105537269306 0.2392 0.8037 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 C24 mock treatment 1.007812E7 -885000.0 -0.5 1.116312E7 -874000.0 -0.49 1.134428E7 -835969.032258101 -0.490859999355988 -0.8547 -1.0 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D01 compound treatment 1.0905E7 -58500.0 -0.03 1.216508E7 128000.0 0.07 1.265572E7 475470.967741899 0.279184598847104 0.1837 0.6331 2065672 ICCB6_000067 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccc(Cl)cc4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D02 compound treatment 1.210808E7 1140000.0 0.64 1.336276E7 1330000.0 0.75 1.36252E7 1444950.9677419 0.848438881975522 1.2917 0.9937 2065673 ICCB6_000068 CC(C)[Si](OC[C@@H]1CC=C(C)B(O)O1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D03 compound treatment 9388240.0 -1580000.0 -0.88 9546360.0 -2490000.0 -1.4 1.128304E7 -897209.032258101 -0.526818587773267 -1.6246 -0.9338 2065674 ICCB6_000069 CCOC(=O)C1[C@H](CCc2ccccc2)O[C@H](CCc3ccccc3)CC1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D04 compound treatment 1.274616E7 1780000.0 1.0 1.36336E7 1600000.0 0.9 1.498076E7 2800510.9677419 1.64438963499524 2.0462 0.9631 2065675 ICCB6_000070 CC(C)[Si](OC[C@H]1OB(O)CC=C1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D05 compound treatment 1.239628E7 1430000.0 0.8 1.3362E7 1320000.0 0.75 1.321264E7 1032390.9677419 0.606194021795363 1.2451 0.9934 2065676 ICCB6_000071 C[Si](C)(C(N[Si](=O)(=O)c1ccccc1)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D06 compound treatment 1.064912E7 -314000.0 -0.18 1.26638E7 626000.0 0.35 1.20472E7 -133049.032258101 -0.0781230468694712 0.0565 0.1406 2065677 ICCB6_000072 CC(C)[Si](OCC(O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D07 compound treatment 1.200928E7 1050000.0 0.59 1.417828E7 2140000.0 1.21 1.337312E7 1192870.9677419 0.700423843304264 1.4393 0.9515 2065678 ICCB6_000073 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C)N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D08 compound treatment 1.320684E7 2240000.0 1.26 1.410932E7 2070000.0 1.17 1.41502E7 1969950.9677419 1.15670568339734 2.0687 0.9992 2065679 ICCB6_000074 CC1=C2[C@H](OB(O)C[C@@H]2[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D09 compound treatment 1.25788E7 1620000.0 0.91 1.416308E7 2130000.0 1.2 1.314996E7 969710.967741899 0.569389901579898 1.5434 0.961 2065680 ICCB6_000075 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](CC(C)C)N1C(=O)CCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D10 compound treatment 1.30442E7 2080000.0 1.17 1.482348E7 2790000.0 1.57 1.382644E7 1646190.9677419 0.966601950771952 2.1383 0.9801 2065681 ICCB6_000076 CC1=C2[C@H](OB(O)C[C@@H]2[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D11 compound treatment 1.184892E7 885000.0 0.5 1.289888E7 861000.0 0.48 1.325828E7 1078030.9677419 0.632992682398966 0.9326 0.9923 2065682 ICCB6_000077 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](Cc5ccccc5)N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D12 compound treatment 1.379332E7 2830000.0 1.59 1.461912E7 2580000.0 1.45 1.462208E7 2441830.9677419 1.43378175626386 2.5845 0.9989 2065683 ICCB6_000078 CC(C)[Si](OCC(O)/C(=C\CO)/C)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D13 compound treatment 1.18054E7 842000.0 0.47 1.378388E7 1750000.0 0.98 1.350072E7 1320470.9677419 0.77534735542126 1.2882 0.9625 1952278 ICCB6_000079 COC(=O)c1nc(oc1C)C(NC(=O)CCc2cn(CC=C)c3ccccc23)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D14 compound treatment 1.321456E7 2250000.0 1.26 1.41784E7 2140000.0 1.21 1.401452E7 1834270.9677419 1.07703779841274 2.0476 0.9978 2065684 ICCB6_000080 CC(C)[Si](OCC(O)/C=C\CO)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D15 compound treatment 9381520.0 -1580000.0 -0.89 1.034948E7 -1690000.0 -0.95 9898000.0 -2282249.0322581 -1.3400792556614 -1.8353 -0.9827 2065685 ICCB6_000081 CCOCOc1cc(O)c(C(=O)/C=C/c2ccccc2)c(OCOCC)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D16 compound treatment 1.30092E7 2050000.0 1.15 1.489228E7 2850000.0 1.61 1.40074E7 1827150.9677419 1.0728571134106 2.2106 0.9833 2065686 ICCB6_000082 CC(C)[Si](OC[C@@H](O)[C@@]1(C)OC(C)(C)OC1CO)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D17 compound treatment 1.210616E7 1140000.0 0.64 1.408392E7 2050000.0 1.15 1.323524E7 1054990.9677419 0.619464173627998 1.3933 0.9563 1952811 ICCB6_000083 CC(C)(C)[Si](C)(C)Oc1ccc(C#C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D18 compound treatment 1.2781E7 1820000.0 1.02 1.4781E7 2740000.0 1.54 1.36936E7 1513350.9677419 0.888601642389335 1.9941 0.9711 2065687 ICCB6_000084 CC(C)[Si](OC[C@@H](O)[C@H]1OC(C)(C)OC1CO)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D19 compound treatment 9536640.0 -1430000.0 -0.8 9981000.0 -2060000.0 -1.16 1.073124E7 -1449009.0322581 -0.850821675439089 -1.6223 -0.9861 1952780 ICCB6_000085 COc1cccc(c1)c2c(oc3ccccc23)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D20 compound treatment 1.222048E7 1260000.0 0.71 1.370644E7 1670000.0 0.94 1.32472E7 1066950.9677419 0.626486784951816 1.3117 0.985 2065688 ICCB6_000086 CC1(C)OC(CO)[C@H](O1)[C@H](O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D21 compound treatment 1.1583E7 619000.0 0.35 1.332372E7 1290000.0 0.72 1.299256E7 812310.967741899 0.476968578639339 0.8943 0.9572 1952670 ICCB6_000087 COCCNC(=O)OC[C@H]1CCC[C@@]2(C[C@@H](C[C@@H](CCC(=O)N[C@@H](C)C(=O)OC)O2)OC(=O)NCCc3ccc(F)cc3)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D22 compound treatment 1.16364E7 673000.0 0.38 1.316784E7 1130000.0 0.64 1.316464E7 984390.967741899 0.578009628522512 0.9193 0.979 2065689 ICCB6_000088 C/C(=C/CO)/[C@H](O)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D23 mock treatment 1.150404E7 540000.0 0.3 1.305496E7 1020000.0 0.57 1.299344E7 813190.967741899 0.477485292516008 0.7817 0.9708 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 D24 mock treatment 1.136124E7 398000.0 0.22 1.21748E7 137000.0 0.08 1.227488E7 94630.9677418992 0.0555649252214211 0.2057 0.8471 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E01 compound treatment 1.156708E7 604000.0 0.34 1.308736E7 1050000.0 0.59 1.258612E7 405870.967741899 0.238317228601469 0.6745 0.9345 2065690 ICCB6_000089 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccc(Cl)c(Cl)c4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E02 compound treatment 8429120.0 -2530000.0 -1.42 8920200.0 -3120000.0 -1.75 9089880.0 -3090369.0322581 -1.81458700340425 -2.8826 -0.9947 2065691 ICCB6_000090 COc1ccc(NC(=O)OC/C=C/c2ccc(CCCCCCO)o2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E03 compound treatment 4939080.0 -6020000.0 -3.38 6159040.0 -5880000.0 -3.31 7272200.0 -4908049.0322581 -2.88188300265834 -5.528 -0.9976 2065692 ICCB6_000091 CCOC(=O)C1[C@@H](O[C@@H](CC1=O)c2ccccc2)C3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E04 compound treatment 1.301096E7 2050000.0 1.15 1.39542E7 1920000.0 1.08 1.319652E7 1016270.9677419 0.596728763054564 1.6314 0.9676 2065693 ICCB6_000092 COc1cccc(c1)c2cc(oc2CCCCCCO)[C@@H](O)[C@H](C)C(=O)N3[C@@H](Cc4ccccc4)COC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E05 compound treatment 1.15648E7 601000.0 0.34 1.247596E7 439000.0 0.25 1.220044E7 20190.9677418992 0.0118556286541072 0.3444 0.8228 2065694 ICCB6_000093 COc1ccc(cc1)C(NP(=O)(c2ccccc2)c3ccccc3)[Si](C)(C)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E06 compound treatment 1.365504E7 2690000.0 1.51 1.40624E7 2020000.0 1.14 1.335864E7 1178390.9677419 0.69192155133362 1.9304 0.9576 2065695 ICCB6_000094 CC(=O)OC/C=C/c1ccc(CCCCCCO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E07 compound treatment 1.305292E7 2090000.0 1.17 1.357636E7 1540000.0 0.87 1.307692E7 896670.967741899 0.526502649816376 1.4817 0.9554 2065696 ICCB6_000095 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](C)N1C(=O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E08 compound treatment 1.235668E7 1390000.0 0.78 1.288368E7 846000.0 0.48 1.386812E7 1687870.9677419 0.991075398930545 1.299 0.9625 2065697 ICCB6_000096 CCOC(=O)c1cccc(NC(=O)OC/C=C/c2ccc(CCCCCCO)o2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E09 compound treatment 1.272424E7 1760000.0 0.99 1.430272E7 2270000.0 1.28 1.33134E7 1133150.9677419 0.665357760673957 1.6913 0.969 2065698 ICCB6_000097 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](CC(C)C)N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E10 compound treatment 1.183744E7 874000.0 0.49 1.254E7 503000.0 0.28 1.305756E7 877310.967741899 0.515134944529659 0.7441 0.9718 2065699 ICCB6_000098 CCCCOC(=O)c1ccc(NC(=O)OC/C=C/c2ccc(CCCCCCO)o2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E11 compound treatment 1.204244E7 1080000.0 0.61 1.384512E7 1810000.0 1.02 1.347244E7 1292190.9677419 0.758742050384672 1.3754 0.9779 1952474 ICCB6_000099 OCCCCCNC(CCO)Cc1ccc2ccccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E12 compound treatment 1.178936E7 826000.0 0.46 1.244892E7 412000.0 0.23 1.247388E7 293630.967741899 0.172412722331785 0.5011 0.9171 2065700 ICCB6_000100 COC(=O)[C@@H](NC(=O)OC/C=C/c1ccc(CCCCCCO)o1)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E13 compound treatment 1.21338E7 1170000.0 0.66 1.420984E7 2170000.0 1.22 1.47646E7 2584350.9677419 1.51746591728983 1.9616 0.9538 1952280 ICCB6_000101 COC(=O)c1nc2oc1CC/C=C/Cn3cc(C[C@H](NC(=O)OC(C)(C)C)C(=O)NC2C(C)C)c4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E14 compound treatment 9950760.0 -1010000.0 -0.57 1.214748E7 110000.0 0.06 1.12406E7 -939649.032258101 -0.551738288825347 -0.6112 -0.7689 2065701 ICCB6_000102 COc1cccc(Cl)c1NC(=O)OC/C=C/c2ccc(CCCCCCO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E15 compound treatment 1.213644E7 1170000.0 0.66 1.366068E7 1620000.0 0.91 1.396652E7 1786270.9677419 1.04885340513989 1.5135 0.9833 1952487 ICCB6_000103 Fc1ccc(cc1Br)[C@H]2C3=CCn4n(C3C[C@@]5(C#N)C(=O)C(=C(Cl)C(=O)[C@@]25C#N)Cl)c(=O)n(c6ccccc6)c4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E16 compound treatment 1.15704E7 607000.0 0.34 1.390216E7 1860000.0 1.05 1.31924E7 1012150.9677419 0.594309602631978 1.146 0.9142 2065702 ICCB6_000104 C[C@@H]([C@H](O)c1cc(c(CCCCCCO)o1)c2ccccc2)C(=O)N3[C@@H](Cc4ccccc4)COC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E17 compound treatment 1.223404E7 1270000.0 0.71 1.31482E7 1110000.0 0.63 1.399508E7 1814830.9677419 1.06562311913724 1.3882 0.973 1952813 ICCB6_000105 OCCCC#Cc1cc(O)cc(Cl)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E18 compound treatment 1.18554E7 892000.0 0.5 1.303316E7 996000.0 0.56 1.275488E7 574630.967741899 0.337408857949936 0.8076 0.9801 2065703 ICCB6_000106 COc1cccc(c1)c2cc(oc2CCCCCCO)[C@@H](OC(=O)C)[C@H](C)C(=O)N3[C@@H](Cc4ccccc4)COC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E19 compound treatment 1.154512E7 582000.0 0.33 1.299352E7 956000.0 0.54 1.424656E7 2066310.9677419 1.21328585289258 1.1998 0.8778 3107406 ICCB6_000107 COC(=O)/C=C/c1cc(OC)c2oc(c(C)c2c1)c3ccccc3.c1ccsc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E20 compound treatment 1.171056E7 747000.0 0.42 1.293392E7 897000.0 0.5 1.35306E7 1350350.9677419 0.792892140233611 0.9914 0.9632 2065704 ICCB6_000108 C[C@@H]([C@H](OC(=O)C)c1cc(c(CCCCCCO)o1)c2ccccc2)C(=O)N3[C@@H](Cc4ccccc4)COC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E21 compound treatment 1.076156E7 -202000.0 -0.11 1.183508E7 -202000.0 -0.11 1.22424E7 62150.9677418992 0.0364934857734582 -0.1102 -0.6684 ICCB6_000109 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E22 compound treatment 1.125284E7 289000.0 0.16 1.233944E7 302000.0 0.17 1.258248E7 402230.967741899 0.236179912111611 0.3283 0.9851 2065705 ICCB6_000110 C[C@@H]([C@H](O)c1cc(c(CCCCCCO)o1)c2cccc(C)c2)C(=O)N3[C@@H](Cc4ccccc4)COC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E23 mock treatment 1.13408E7 377000.0 0.21 1.291924E7 882000.0 0.5 1.304388E7 863630.967741899 0.507102392446896 0.7017 0.9475 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 E24 mock treatment 1.089508E7 -68500.0 -0.04 1.176956E7 -268000.0 -0.15 1.219172E7 11470.9677418992 0.00673546387620584 -0.1054 -0.6765 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F01 compound treatment 1.08868E7 -76700.0 -0.04 1.236364E7 326000.0 0.18 1.219116E7 10910.9677418992 0.00640664595468924 0.0848 0.4495 2065706 ICCB6_000111 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccc(OC)cc4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F02 compound treatment 1.104812E7 84600.0 0.05 1.170144E7 -336000.0 -0.19 1.220596E7 25710.9677418992 0.0150968338804851 -0.073 -0.3735 2065707 ICCB6_000112 CC(C)[Si](OC[C@@H](O)C(C=C)C(O)c1ccccc1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F03 compound treatment 1.17404E7 777000.0 0.44 1.316912E7 1130000.0 0.64 1.3173E7 992750.967741899 0.582918410350867 0.9563 0.9884 1009686 ICCB6_000113 O=C(CC(C(=O)c1ccccc1)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F04 compound treatment 1.266192E7 1700000.0 0.95 1.478648E7 2750000.0 1.55 1.324216E7 1061910.9677419 0.623527423658167 1.8042 0.9388 2065708 ICCB6_000114 OC/C=C\C(O)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F05 compound treatment 1.247544E7 1510000.0 0.85 1.363024E7 1590000.0 0.9 1.377624E7 1595990.9677419 0.937125772807428 1.549 0.9992 2065709 ICCB6_000115 CCCCCCCCNC(=O)CC[C@H]1O[C@H](O[C@H]2O[C@H](CCC(=O)NCCCCCCCC)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F06 compound treatment 1.363376E7 2670000.0 1.5 1.429188E7 2250000.0 1.27 1.448056E7 2300310.9677419 1.35068477009774 2.3784 0.9976 2065710 ICCB6_000116 CC1=C([C@H](O)C(C)(C)C)[C@H](CO)[C@H]2[C@@H](C1)C(=O)N(Cc3ccccc3)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F07 compound treatment 1.24376E7 1470000.0 0.83 1.447012E7 2430000.0 1.37 1.36624E7 1482150.9677419 0.870281786761982 1.7711 0.9723 2065711 ICCB6_000117 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C)N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F08 compound treatment 1.36336E7 2670000.0 1.5 1.457104E7 2530000.0 1.43 1.444496E7 2264710.9677419 1.32978134508704 2.457 0.9988 2065712 ICCB6_000118 CC1=C([C@H](O)c2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F09 compound treatment 1.18338E7 870000.0 0.49 1.311084E7 1070000.0 0.6 1.30928E7 912550.967741899 0.535826986590811 0.9404 0.9962 2065713 ICCB6_000119 CCOC(=O)CC1[C@@H]2[C@@H](NCc3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](CC(C)C)N1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F10 compound treatment 1.36488E7 2690000.0 1.51 1.464988E7 2610000.0 1.47 1.479436E7 2614110.9677419 1.534940241119 2.606 0.9998 2065714 ICCB6_000120 C[C@@H](O)C1=CC[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F11 compound treatment 1.27722E7 1810000.0 1.02 1.359616E7 1560000.0 0.88 1.366984E7 1489590.9677419 0.874650367719274 1.5981 0.9975 1952476 ICCB6_000121 OCCCCCN(Cc1ccccc1Br)[C@@H](COCc2c(Br)sc3ccc(Cl)cc23)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F12 compound treatment 1.383124E7 2870000.0 1.61 1.436736E7 2330000.0 1.31 1.488204E7 2701790.9677419 1.58642373283074 2.6031 0.996 2065715 ICCB6_000122 OC[C@@H]1[C@H]2[C@@H](CC=C1CO)C(=O)N(Cc3ccccc3)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F13 compound treatment 1.298872E7 2030000.0 1.14 1.632044E7 4280000.0 2.41 1.469468E7 2514430.9677419 1.47641065108905 2.9011 0.952 1952282 ICCB6_000123 COC(=O)c1nc2oc1CC/C=C/CNC(=O)O[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NC2C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F14 compound treatment 1.317312E7 2210000.0 1.24 1.453284E7 2500000.0 1.4 1.451164E7 2331390.9677419 1.36893416474191 2.3179 0.9986 2065716 ICCB6_000124 CC1=C(CO)[C@H](CO)[C@H]2[C@@H](C1)C(=O)N(Cc3ccccc3)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F15 compound treatment 9819320.0 -1140000.0 -0.64 1.076344E7 -1270000.0 -0.72 1.051132E7 -1668929.0322581 -0.979953170617537 -1.3509 -0.9832 1952488 ICCB6_000125 Fc1ccc(cc1Br)[C@H]2C3=CCC4=C(C3CC5=C2C(=O)C(=CC5=O)I)C(=O)C(=CC4=O)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F16 compound treatment 1.33044E7 2340000.0 1.31 1.434336E7 2310000.0 1.3 1.453848E7 2358230.9677419 1.38469393798031 2.308 0.9996 2065717 ICCB6_000126 C/C(=C/CO)/C(O)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F17 compound treatment 1.211328E7 1150000.0 0.65 1.350072E7 1460000.0 0.82 1.363796E7 1457710.9677419 0.855931233187222 1.3426 0.993 1952814 ICCB6_000127 CC(=O)Cc1c(Cl)cc(cc1I)C(=O)NCCO[Si](C)(C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F18 compound treatment 1.237956E7 1420000.0 0.8 1.404516E7 2010000.0 1.13 1.429752E7 2117270.9677419 1.2432082837506 1.8295 0.9842 2065718 ICCB6_000128 CC(C)[Si](OCC1OB(O)CC=C1C)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F19 compound treatment 1.007284E7 -891000.0 -0.5 1.033336E7 -1700000.0 -0.96 1.058996E7 -1590289.0322581 -0.933777739638849 -1.3818 -0.9669 1952785 ICCB6_000129 CCc1cc(OC)c2oc(c(C(=O)c3ccccc3)c2c1)c4ccc(Oc5ccccc5)c(OC)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F20 compound treatment 1.131852E7 355000.0 0.2 1.309832E7 1060000.0 0.6 1.251256E7 332310.967741899 0.195124645910824 0.5726 0.8686 2065719 ICCB6_000130 OB1CC=C(C(O1)c2ccccc2)C(=C)COCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F21 compound treatment 1.229952E7 1340000.0 0.75 1.342724E7 1390000.0 0.78 1.343392E7 1253670.9677419 0.736124074783209 1.3099 0.9997 3107360 ICCB6_000131 Cc1ccc(cc1)S(=O)(=O)O.Cc1cc(=O)oc2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F22 compound treatment 1.118172E7 218000.0 0.12 1.18522E7 -185000.0 -0.1 1.254492E7 364670.967741899 0.214125624375605 0.1342 0.501 2065720 ICCB6_000132 OC/C=C(\C(O)c1ccccc1)/C(=C)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F23 mock treatment 1.239376E7 1430000.0 0.8 1.252576E7 488000.0 0.27 1.311308E7 932830.967741899 0.54773489274859 0.9387 0.9291 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 F24 mock treatment 1.08492E7 -114000.0 -0.06 1.130532E7 -732000.0 -0.41 1.249464E7 314390.967741899 0.184602472422293 -0.1684 -0.3693 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G01 compound treatment 1.148176E7 518000.0 0.29 1.262704E7 590000.0 0.33 1.141332E7 -766929.032258101 -0.450321447031869 0.0997 0.1581 2065721 ICCB6_000133 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4cccs4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G02 compound treatment 1.223968E7 1280000.0 0.72 1.388604E7 1850000.0 1.04 1.326392E7 1083670.9677419 0.636304348608526 1.382 0.9768 3057351 ICCB6_000134 CC(C)C[C@H](CI)C(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G03 compound treatment 1.176596E7 802000.0 0.45 1.2809E7 772000.0 0.43 1.302932E7 849070.967741899 0.498553126487465 0.7988 0.9983 2065722 ICCB6_000135 Clc1ccc(cc1)C(NP(=O)(c2ccccc2)c3ccccc3)C(=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G04 compound treatment 1.268948E7 1730000.0 0.97 1.413552E7 2100000.0 1.18 1.358852E7 1408270.9677419 0.826901308116185 1.719 0.9894 3057353 ICCB6_000136 CC(C)(C)OC[C@@H](O)[C@H]1O[C@H](NO)C2OC(C)(C)OC12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G05 compound treatment 1.27068E7 1740000.0 0.98 1.477356E7 2740000.0 1.54 1.428432E7 2104070.9677419 1.23545757560056 2.1678 0.9836 2065723 ICCB6_000137 CCCCCCCNCC(=O)NC[C@H]1O[C@H](O[C@H]2O[C@H](CNC(=O)CCNCCCCCC)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G06 compound treatment 1.32792E7 2320000.0 1.3 1.4904E7 2870000.0 1.61 1.598164E7 3801390.9677419 2.23208120872298 2.9713 0.9755 2065724 ICCB6_000138 CC(C)[Si](C)(C)Oc1cccc2C(C=C)N(C=Cc12)C(=O)c3ccccc3Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G07 compound treatment 1.2315E7 1350000.0 0.76 1.599776E7 3960000.0 2.23 1.46232E7 2442950.9677419 1.43443939210689 2.5535 0.926 2065725 ICCB6_000139 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C)N1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G08 compound treatment 1.37676E7 2800000.0 1.57 1.451404E7 2480000.0 1.39 1.490788E7 2727630.9677419 1.6015963312093 2.6389 0.9982 2065726 ICCB6_000140 CC(C)(C)[Si](C)(C)OCC1=CC(C#C)N(C=C1)C(=O)c2ccccc2Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G09 compound treatment 1.060448E7 -359000.0 -0.2 1.386084E7 1820000.0 1.03 1.401208E7 1831830.9677419 1.07560509175471 1.0972 0.7313 2065727 ICCB6_000141 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](CC(C)C)N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G10 compound treatment 1.310044E7 2140000.0 1.2 1.543032E7 3390000.0 1.91 1.491076E7 2730510.9677419 1.60328739480567 2.7213 0.9833 3057357 ICCB6_000142 OC(=O)c1[se]c2ccccc2c1Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G11 compound treatment 1.259792E7 1630000.0 0.92 1.415504E7 2120000.0 1.19 1.447784E7 2297590.9677419 1.34908765447894 1.9971 0.9883 1952478 ICCB6_000143 OCCCCCN(Cc1ccccc1Br)[C@@H](COCc2ccc3ccccc3c2Br)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G12 compound treatment 1.2116E7 1150000.0 0.65 1.308484E7 1050000.0 0.59 1.21302E7 -50049.0322581008 -0.0293875335018322 0.6972 0.7958 3057359 ICCB6_000144 CC(C)(C)[Si](C)(C)OCC1=CC(C=C)N(C=C1)C(=O)c2[se]c3ccccc3c2Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G13 compound treatment 1.302864E7 2070000.0 1.16 1.43582E7 2320000.0 1.31 1.416872E7 1988470.9677419 1.16758016180178 2.098 0.9985 1952284 ICCB6_000145 COC(=O)c1nc2oc1CC/C=C/CNC(=O)O[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H]2C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G14 compound treatment 1.272276E7 1760000.0 0.99 1.441944E7 2380000.0 1.34 1.419916E7 2018910.9677419 1.18545376453564 2.0291 0.9925 2065728 ICCB6_000146 CCCCCC1C=C(CO[Si](C)(C)C(C)(C)C)C=CN1C(=O)c2ccccc2Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G15 compound treatment 1.04714E7 -492000.0 -0.28 1.14984E7 -539000.0 -0.3 1.233052E7 150270.967741899 0.0882353344235348 -0.2838 -0.6761 2065729 ICCB6_000147 CCOCOc1cc(OCOCC)c2C(=O)CC(Oc2c1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G16 compound treatment 1.282272E7 1860000.0 1.04 1.405812E7 2020000.0 1.14 1.500576E7 2825510.9677419 1.65906900649152 2.2175 0.9784 2065730 ICCB6_000148 CC(C)(C)[Si](C)(C)Oc1cccc2C(C=C)N(C=Cc12)C(=O)c3ccccc3Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G17 compound treatment 1.206056E7 1100000.0 0.62 1.360692E7 1570000.0 0.88 1.362996E7 1449710.9677419 0.851233834308413 1.3573 0.9886 1952760 ICCB6_000149 CC(C)(C)[Si](C)(C)OCCNC(=O)c1cc(c2cc(F)cc(F)c2)c3oc4c(C(=O)OC4(c5ccccc5)c6ccccc6)c3c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G18 compound treatment 1.237392E7 1410000.0 0.79 1.385224E7 1810000.0 1.02 1.433128E7 2151030.9677419 1.26303130701917 1.7764 0.9829 2065731 ICCB6_000150 CC(=O)N[C@@H](CI)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G19 compound treatment 1.107956E7 116000.0 0.07 1.265532E7 618000.0 0.35 1.310376E7 923510.967741899 0.542262423054778 0.5515 0.8517 1952788 ICCB6_000151 CCc1cc(OC)c2oc(c(C(=O)c3ccc(OC)cc3)c2c1)c4ccc(Oc5ccccc5)c(OC)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G20 compound treatment 1.27408E7 1780000.0 1.0 1.365644E7 1620000.0 0.91 1.318956E7 1009310.9677419 0.592642026030001 1.4447 0.9788 2065732 ICCB6_000152 COc1cc2CCN(Cc3ccccc3Br)C(C=C)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G21 compound treatment 1.209176E7 1130000.0 0.63 1.390036E7 1860000.0 1.05 1.383256E7 1652310.9677419 0.97019546091424 1.5315 0.9799 1952728 ICCB6_000153 Cc1ccc2oc(=O)cc(c3cccs3)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G22 compound treatment 1.193244E7 969000.0 0.54 1.399428E7 1960000.0 1.1 1.2831E7 650750.967741899 0.3821046082818 1.1708 0.9099 2065733 ICCB6_000154 CN1C(=O)C2C(C1=O)C3(C4C(C5C=C(CCCO[Si](C)(C)C(C)(C)C)CC2N53)C(=O)N(C)C4=O)C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G23 mock treatment 1.150648E7 543000.0 0.3 1.32202E7 1180000.0 0.67 1.292156E7 741310.967741899 0.435279163589913 0.8118 0.9529 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 G24 mock treatment 1.182616E7 863000.0 0.48 1.268168E7 644000.0 0.36 1.30738E7 893550.967741899 0.52467066425364 0.792 0.9888 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H01 compound treatment 1.21808E7 1220000.0 0.68 1.346032E7 1420000.0 0.8 1.376368E7 1583430.9677419 0.929750856567699 1.394 0.9923 2065734 ICCB6_000155 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccccc4Cl)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H02 compound treatment 1.27276E7 1760000.0 0.99 1.397476E7 1940000.0 1.09 1.404896E7 1868710.9677419 1.09726010058601 1.8352 0.9989 2065735 ICCB6_000156 CC(=C)C1=CCB(O)OC1c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H03 compound treatment 1.256412E7 1600000.0 0.9 1.380896E7 1770000.0 1.0 1.367576E7 1495510.9677419 0.878126442889592 1.6018 0.9984 2065736 ICCB6_000157 CC(C(NP(=O)(c1ccccc1)c2ccccc2)c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H04 compound treatment 1.255668E7 1590000.0 0.89 1.40156E7 1980000.0 1.11 1.38896E7 1709350.9677419 1.00368791492015 1.739 0.9961 2065737 ICCB6_000158 CN1C(=O)[C@@H]2CC(=C([C@H](O)c3ccccc3)[C@H](CO)[C@@H]2C1=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H05 compound treatment 1.2494E7 1530000.0 0.86 1.35382E7 1500000.0 0.84 1.35376E7 1357350.9677419 0.797002364252568 1.4442 0.9995 2065738 ICCB6_000159 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)CN1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H06 compound treatment 1.237184E7 1410000.0 0.79 1.352552E7 1490000.0 0.84 1.371176E7 1531510.9677419 0.899264737844231 1.4595 0.9986 2065739 ICCB6_000160 CC(=C)/C(=C/CO)/C(O)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H07 compound treatment 1.210196E7 1140000.0 0.64 1.325092E7 1210000.0 0.68 1.406176E7 1881510.9677419 1.10477593879211 1.4014 0.968 2065740 ICCB6_000161 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](C)N1C(=O)Cc4ccc(OC)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H08 compound treatment 1.264512E7 1680000.0 0.94 1.400324E7 1970000.0 1.11 1.485212E7 2671870.9677419 1.568855461024 2.09 0.9768 2065741 ICCB6_000162 CC1=NC(C)(C)[C@@H]2CCC(=C)C1C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H09 compound treatment 1.195572E7 992000.0 0.56 1.31144E7 1080000.0 0.61 1.372624E7 1545990.9677419 0.907767029814874 1.1959 0.9757 2065742 ICCB6_000163 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](CC(C)C)N1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H10 compound treatment 1.324972E7 2290000.0 1.28 1.450928E7 2470000.0 1.39 1.483556E7 2655310.9677419 1.55913184534487 2.4449 0.9968 2065743 ICCB6_000164 C[C@H]1NC(C)(C)C2CCC(=C)[C@H]1C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H11 compound treatment 1.27972E7 1830000.0 1.03 1.469932E7 2660000.0 1.5 1.505048E7 2870230.9677419 1.68532746622406 2.4328 0.9813 1952534 ICCB6_000165 C[C@H](N)C(Oc1ccccc1Br)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H12 compound treatment 1.37818E7 2820000.0 1.58 1.57612E7 3720000.0 2.1 1.463564E7 2455390.9677419 1.44174384736344 2.9565 0.9867 2065744 ICCB6_000166 C[C@@H]1[C@@H]2CC(CCC2=C)C(C)(C)N1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H13 compound treatment 1.228632E7 1320000.0 0.74 1.341176E7 1370000.0 0.77 1.311608E7 935830.967741899 0.549496417328144 1.1929 0.9898 1952286 ICCB6_000167 COC(=O)c1nc(oc1CCC=C)C(NC(=O)[C@H](Cc2cn(CC=C)cn2)NC(=O)OCc3ccccc3)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H14 compound treatment 1.304028E7 2080000.0 1.17 1.495568E7 2920000.0 1.64 1.380832E7 1628070.9677419 0.955962342311451 2.1738 0.9748 2065745 ICCB6_000168 CC(C)C[C@H]1NC(C)(C)C2CCC(=C)[C@H]1C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H15 compound treatment 1.018884E7 -775000.0 -0.44 1.166788E7 -370000.0 -0.21 1.228076E7 100510.967741899 0.0590175133973454 -0.3372 -0.6941 1952677 ICCB6_000169 CCCCCCC#Cc1c(C(CC(=O)C)c2ccccc2)c(=O)oc3ccccc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H16 compound treatment 1.292648E7 1960000.0 1.1 1.439952E7 2360000.0 1.33 1.454996E7 2369710.9677419 1.3914347053714 2.2076 0.9953 2065746 ICCB6_000170 CC(C)C[C@@H]1[C@@H]2CC(CCC2=C)C(C)(C)N1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H17 compound treatment 1.15444E7 581000.0 0.33 1.372272E7 1690000.0 0.95 1.421736E7 2037110.9677419 1.19614034698493 1.4267 0.9139 1952821 ICCB6_000171 CC(C)(C)[Si](C)(C)COCNC(=O)C1CC2C3C(OC2C(Cl)C1)C4(CCCC4)OC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H18 compound treatment 1.219112E7 1230000.0 0.69 1.541004E7 3370000.0 1.9 1.315236E7 972110.967741899 0.570799121243541 1.8237 0.8689 2065747 ICCB6_000172 COc1cc(C[C@H]2NC(C)(C)C3CCC(=C)[C@H]2C3)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H19 compound treatment 1.256532E7 1600000.0 0.9 1.406004E7 2020000.0 1.14 1.362056E7 1440310.9677419 0.845714390625813 1.6651 0.9914 1952600 ICCB6_000173 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCc3ccccc3)O2)O1)OC(=O)NCc4cccc5ccccc45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H20 compound treatment 1.123336E7 270000.0 0.15 1.176044E7 -277000.0 -0.16 1.251172E7 331470.967741899 0.194631419028549 0.1099 0.3765 2065748 ICCB6_000174 COc1cc(C[C@@H]2[C@@H]3CC(CCC3=C)C(C)(C)N2C)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H21 compound treatment 1.30812E7 2120000.0 1.19 1.342972E7 1390000.0 0.78 1.289276E7 712510.967741899 0.418368527626202 1.3808 0.9301 1952730 ICCB6_000175 O=c1cc(Cc2ccccc2)c3ccccc3o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H22 compound treatment 1.15364E7 573000.0 0.32 1.287152E7 834000.0 0.47 1.287476E7 694510.967741899 0.407799380148883 0.6923 0.9887 2065749 ICCB6_000176 CC1(C)N=C(/C=C/2\C(=O)Nc3ccccc23)[C@@H]4CC1CCC4=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H23 mock treatment 1.200116E7 1040000.0 0.58 1.363756E7 1600000.0 0.9 1.31392E7 958950.967741899 0.563071900087901 1.1816 0.9752 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 H24 mock treatment 1.151372E7 550000.0 0.31 1.191436E7 -123000.0 -0.07 1.25104E7 330150.967741899 0.193856348213546 0.2503 0.6742 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I01 compound treatment 1.115672E7 193000.0 0.11 1.263596E7 599000.0 0.34 1.194624E7 -234009.032258101 -0.137404220720036 0.1778 0.4684 2065750 ICCB6_000177 COC(=O)[C@@H]1[C@H](N([C@H](c2ccccc2)[C@@]13C(=O)N(Cc4ccccc4)c5ccccc53)c6ccccc6)C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I02 compound treatment 6714960.0 -4250000.0 -2.39 7329840.0 -4710000.0 -2.65 7608200.0 -4572049.0322581 -2.68459224974838 -4.4577 -0.9987 2065751 ICCB6_000178 CC(C)(C)[Si](C)(C)OCCCC1=CC2C3C(C(=O)N(Cc4ccccc4)C3=O)C5(C6C(C(C1)N25)C(=O)N(Cc7ccccc7)C6=O)C(=O)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I03 compound treatment 1.11226E7 159000.0 0.09 1.27754E7 738000.0 0.42 1.284904E7 668790.967741899 0.392697242753513 0.5181 0.8955 2065752 ICCB6_000179 CCOC(=O)[C@H]1N(C(C(=C1C(=O)OC)C(=O)OC)c2ccc(Cl)cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I04 compound treatment 1.156384E7 600000.0 0.34 1.287032E7 833000.0 0.47 1.314828E7 968030.967741899 0.568403447815348 0.7935 0.9793 2065753 ICCB6_000180 COc1cc(CN[C@@H](C)[C@H](Oc2ccccc2Br)c3ccccc3)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I05 compound treatment 1.09186E7 -44900.0 -0.03 1.306396E7 1030000.0 0.58 1.304668E7 866430.967741899 0.508746482054479 0.6128 0.7955 2065754 ICCB6_000181 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)CN1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I06 compound treatment 1.13656E7 402000.0 0.23 1.350604E7 1470000.0 0.83 1.277504E7 594790.967741899 0.349246303124534 0.8093 0.8745 2065755 ICCB6_000182 COc1cc(CN[C@H]([C@H](O)c2ccccc2)c3ccccc3)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I07 compound treatment 1.212152E7 1160000.0 0.65 1.333984E7 1300000.0 0.73 1.36968E7 1516550.9677419 0.890480601940859 1.3129 0.9915 2065756 ICCB6_000183 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C)N1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I08 compound treatment 1.077604E7 -188000.0 -0.11 9975320.0 -2060000.0 -1.16 1.177224E7 -408009.032258101 -0.239572646334122 -0.8693 -0.7306 2065757 ICCB6_000184 COc1cc(CN(Cc2ccccc2Br)[C@H]([C@H](O)c3ccccc3)c4ccccc4)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I09 compound treatment 1.161368E7 650000.0 0.37 1.386388E7 1830000.0 1.03 1.400396E7 1823710.9677419 1.07083723189271 1.4227 0.9306 2065758 ICCB6_000185 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](CC(C)C)N1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I10 compound treatment 1.235584E7 1390000.0 0.78 1.409696E7 2060000.0 1.16 1.414516E7 1964910.9677419 1.15374632210369 1.787 0.9857 2065759 ICCB6_000186 COc1cc(CN(Cc2ccccc2Br)[C@H](C)C(Oc3ccccc3Br)c4ccccc4)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I11 compound treatment 1.333796E7 2370000.0 1.33 1.479724E7 2760000.0 1.55 1.397088E7 1790630.9677419 1.05141348752884 2.274 0.988 1952544 ICCB6_000187 O=C1Nc2ccccc2[C@@]31[C@@H](C#N)C4N([C@H]3c5ccccc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I12 compound treatment 1.43998E7 3440000.0 1.93 1.585432E7 3820000.0 2.15 1.444908E7 2268830.9677419 1.33220050550962 3.124 0.9822 2065760 ICCB6_000188 COc1cc(CN(Cc2ccccc2Br)[C@H](C(Oc3ccccc3Br)c4ccccc4)c5ccccc5)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I13 compound treatment 1.168776E7 724000.0 0.41 1.224908E7 212000.0 0.12 1.328924E7 1108990.9677419 0.651171616059956 0.6796 0.8747 1952288 ICCB6_000189 COC(=O)c1nc2oc1CC/C=C/Cn3cnc(C[C@H](NC(=O)OCc4ccccc4)C(=O)NC2C(C)C)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I14 compound treatment 1.148676E7 523000.0 0.29 1.37696E7 1730000.0 0.98 1.316076E7 980510.967741899 0.57573139006629 1.065 0.9104 2065761 ICCB6_000190 C[C@@H](C(Oc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-])c2ccccc2)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I15 compound treatment 1.237308E7 1410000.0 0.79 1.406316E7 2030000.0 1.14 1.388488E7 1704630.9677419 1.00091644958165 1.6933 0.9894 1952679 ICCB6_000191 Clc1ccc2oc(=O)cc(Sc3ccccc3)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I16 compound treatment 1.275888E7 1800000.0 1.01 1.347052E7 1430000.0 0.81 1.351904E7 1338790.9677419 0.786104398853732 1.5018 0.9934 2065762 ICCB6_000192 C[C@H](C(Oc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-])c2ccccc2)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I17 compound treatment 1.078344E7 -180000.0 -0.1 1.122664E7 -811000.0 -0.46 1.09212E7 -1259049.0322581 -0.739281939061779 -0.7487 -0.856 1952823 ICCB6_000193 C#Cc1ccccc1Oc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I18 compound treatment 1.230608E7 1340000.0 0.75 1.275996E7 723000.0 0.41 1.31526E7 972350.967741899 0.570940043209905 0.9998 0.9711 2065763 ICCB6_000194 C[C@H](C(Oc1ccc(cc1)[N+](=O)[O-])c2ccccc2)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I19 compound treatment 379480.0 -1.06E7 -5.94 467920.0 -1.16E7 -6.51 279600.0 -1.19006490322581E7 -6.98776192765296 -11.2267 -0.9978 1952601 ICCB6_000195 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCCOc3ccccc3)O2)O1)OC(=O)NCc4cccc5ccccc45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I20 compound treatment 1.158228E7 619000.0 0.35 1.297848E7 941000.0 0.53 1.326432E7 1084070.9677419 0.636539218552467 0.874 0.9732 2065764 ICCB6_000196 C[C@H]([C@@H](Oc1ccccc1Br)c2ccccc2)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I21 compound treatment 8830320.0 -2130000.0 -1.2 9940640.0 -2100000.0 -1.18 1.084668E7 -1333569.0322581 -0.783038209617881 -1.8253 -0.9839 1952746 ICCB6_000197 Cc1ccc(cc1)c2cc(=O)oc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I22 compound treatment 1.204568E7 1080000.0 0.61 1.287592E7 839000.0 0.47 1.27048E7 524550.967741899 0.308003140968594 0.8013 0.9666 2065765 ICCB6_000198 C[C@@H]([C@@H](Oc1ccccc1Br)c2ccccc2)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I23 mock treatment 1.150244E7 539000.0 0.3 1.250656E7 469000.0 0.26 1.248188E7 301630.967741899 0.177110121210593 0.4295 0.9783 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 I24 mock treatment 1.057752E7 -386000.0 -0.22 1.253256E7 495000.0 0.28 1.200396E7 -176289.032258101 -0.103512487809432 -0.024 -0.0653 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J01 compound treatment 322120.0 -1.06E7 -5.98 403160.0 -1.16E7 -6.55 216240.0 -1.19640090322581E7 -7.02496532677312 -11.2878 -0.9978 2065766 ICCB6_000199 COC(=O)C1=CN([C@H](c2ccccc2)[C@]31C(=O)N(Cc4ccccc4)c5ccccc53)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J02 compound treatment 1.018252E7 -781000.0 -0.44 1.127056E7 -767000.0 -0.43 1.137104E7 -809209.032258101 -0.475147200106373 -0.7768 -0.9991 2065767 ICCB6_000200 CC1(C)N[C@H](CC2C(=O)Nc3ccccc23)[C@@H]4CC1CCC4=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J03 compound treatment 1.158936E7 626000.0 0.35 1.288088E7 843000.0 0.47 1.28676E7 687350.967741899 0.403595208152349 0.7101 0.9925 2065768 ICCB6_000201 CCOC(=O)[C@H]1N(C(C(=C1C(=O)OC)C(=O)OC)c2ccc(Br)cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J04 compound treatment 1.136744E7 404000.0 0.23 1.31026E7 1070000.0 0.6 1.289408E7 713830.967741899 0.419143598441205 0.7192 0.9389 2065769 ICCB6_000202 CN1[C@H](CC2C(=O)Nc3ccccc23)[C@@H]4CC(CCC4=C)C1(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J05 compound treatment 1.075384E7 -210000.0 -0.12 1.271772E7 680000.0 0.38 1.285224E7 671990.967741899 0.394576202305037 0.3809 0.6774 2065770 ICCB6_000203 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)CN1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J06 compound treatment 1.117236E7 209000.0 0.12 1.265376E7 616000.0 0.35 1.250704E7 326790.967741899 0.191883440684446 0.3788 0.9162 2065771 ICCB6_000204 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)OCC=C)[C@@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J07 compound treatment 1.289428E7 1930000.0 1.08 1.36076E7 1570000.0 0.88 1.2907E7 726750.967741899 0.426729897630481 1.3828 0.9454 2065772 ICCB6_000205 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C(C)C)N1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J08 compound treatment 1.201772E7 1050000.0 0.59 1.390392E7 1870000.0 1.05 1.336272E7 1182470.9677419 0.694317224761812 1.3493 0.9696 2065773 ICCB6_000206 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)OCC=C)[C@@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J09 compound treatment 1.298764E7 2020000.0 1.14 1.481956E7 2780000.0 1.57 1.314772E7 967470.967741899 0.568074629893832 1.8886 0.9364 2065774 ICCB6_000207 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](CC(C)C)N1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J10 compound treatment 1.041932E7 -544000.0 -0.31 1.260504E7 568000.0 0.32 1.315504E7 974790.967741899 0.572372749867942 0.3385 0.4679 2065775 ICCB6_000208 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)OCC=C)[C@@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J11 compound treatment 1.056676E7 -397000.0 -0.22 1.113516E7 -902000.0 -0.51 1.101436E7 -1165889.0322581 -0.684580729118053 -0.8171 -0.9275 2065776 ICCB6_000209 Cc1ccc(SC2(CC(=O)N(Cc3ccccc3)C2c4ccccc4I)C(=O)NCc5ccccc5)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J12 compound treatment 1.31506E7 2190000.0 1.23 1.368188E7 1640000.0 0.93 1.54762E7 3295950.9677419 1.93529954755986 2.361 0.9551 2065777 ICCB6_000210 OCCOc1cccc(c1)[C@@H]2N3[C@H]([C@H](C(=O)OCC=C)[C@@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J13 compound treatment 8501240.0 -2460000.0 -1.38 7985360.0 -4050000.0 -2.28 9666280.0 -2513969.0322581 -1.47613941418609 -2.9676 -0.9734 1952295 ICCB6_000211 COC(=O)c1nc(oc1CC(=O)CCl)C(NC(=O)NC(=O)OC(C)(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J14 compound treatment 1.22772E7 1310000.0 0.74 1.329824E7 1260000.0 0.71 1.416016E7 1979910.9677419 1.16255394500145 1.507 0.9728 2065778 ICCB6_000212 OCc1ccc(o1)[C@@H]2N3[C@H]([C@H](C(=O)OCC=C)[C@@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J15 compound treatment 1.266484E7 1700000.0 0.96 1.422632E7 2190000.0 1.23 1.420072E7 2020470.9677419 1.18636975731701 1.948 0.9943 1952690 ICCB6_000213 COC(=O)CC(C(=O)OC)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J16 compound treatment 1.1894E7 930000.0 0.52 1.361492E7 1580000.0 0.89 1.464268E7 2462430.9677419 1.44587755837679 1.6492 0.9289 2065779 ICCB6_000214 CON(C)C(=O)[C@H]1C2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCC(C(=O)OC)C(=O)OC)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J17 compound treatment 1.193648E7 973000.0 0.55 1.360648E7 1570000.0 0.88 1.471832E7 2538070.9677419 1.49029146477593 1.6859 0.9281 1952825 ICCB6_000215 CCCC(C)(O)C#Cc1cc(cc(C(=O)NCCO[Si](C)(C)C(C)(C)C)c1OC(=O)C)c2cc(F)cc(F)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J18 compound treatment 1.225504E7 1290000.0 0.73 1.272916E7 692000.0 0.39 1.248056E7 300310.967741899 0.17633505039559 0.7454 0.8853 2065780 ICCB6_000216 CON(C)C(=O)[C@H]1C2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J19 compound treatment 372840.0 -1.06E7 -5.95 496680.0 -1.15E7 -6.5 287320.0 -1.18929290322581E7 -6.98322893773491 -11.2169 -0.9979 1952605 ICCB6_000217 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCCC(C)C)O2)O1)OC(=O)NCc3cccc4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J20 compound treatment 1.185604E7 892000.0 0.5 1.379952E7 1760000.0 0.99 1.402148E7 1841230.9677419 1.08112453543731 1.4863 0.9586 2065781 ICCB6_000218 CON(C)C(=O)[C@H]1C2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J21 compound treatment 1.159784E7 634000.0 0.36 1.293244E7 895000.0 0.5 1.40258E7 1845550.9677419 1.08366113083186 1.1222 0.8999 3005760 ICCB6_000219 CCOP(=O)(O)OCC.Cc1cc(=O)oc2ccc(Cl)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J22 compound treatment 1.19268E7 963000.0 0.54 1.346472E7 1430000.0 0.8 1.3819E7 1638750.9677419 0.96223336981466 1.3318 0.9754 2065782 ICCB6_000220 CON(C)C(=O)[C@H]1C2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCNC(=O)N)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J23 mock treatment 1.129884E7 335000.0 0.19 1.24756E7 438000.0 0.25 1.312928E7 949030.967741899 0.557247125478178 0.5729 0.8981 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 J24 mock treatment 1.05554E7 -408000.0 -0.23 1.13744E7 -663000.0 -0.37 1.25248E7 344550.967741899 0.202311666195401 -0.231 -0.4788 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K01 compound treatment 9133720.0 -1830000.0 -1.03 9817320.0 -2220000.0 -1.25 1.069028E7 -1489969.0322581 -0.874872357698589 -1.82 -0.9894 2065783 ICCB6_000221 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccccc4)C(=O)N(C)c5ccccc52 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K02 compound treatment 1.162552E7 662000.0 0.37 1.246756E7 430000.0 0.24 1.288324E7 702990.967741899 0.41277862296042 0.5928 0.9782 2065784 ICCB6_000222 CC(Oc1ccccc1Br)[C@H](N(C)C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K03 compound treatment 1.196416E7 1000000.0 0.56 1.24162E7 379000.0 0.21 1.173984E7 -440409.032258101 -0.258597111793297 0.2983 0.4558 2065785 ICCB6_000223 COC(=O)C(C(c1ccc(OC)cc1)[Si](C)(C)c2ccccc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K04 compound treatment 1.076356E7 -200000.0 -0.11 1.201384E7 -23600.0 -0.01 1.202932E7 -150929.032258101 -0.0886217333636084 -0.1237 -0.8607 2065786 ICCB6_000224 C[C@H](C(Oc1ccccc1[N+](=O)[O-])c2ccccc2)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K05 compound treatment 1.10004E7 36900.0 0.02 1.215524E7 118000.0 0.07 1.245208E7 271830.967741899 0.159612310387031 0.1424 0.818 2065787 ICCB6_000225 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)CN1C(=O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K06 compound treatment 1.146328E7 500000.0 0.28 1.276336E7 726000.0 0.41 1.191364E7 -266609.032258101 -0.156546121151181 0.3076 0.5917 2065788 ICCB6_000226 COc1cc(/C=C/C=O)ccc1O[Si](C(C)C)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K07 compound treatment 1.082864E7 -135000.0 -0.08 1.256408E7 527000.0 0.3 1.237848E7 198230.967741899 0.116396240701992 0.1946 0.5945 2065789 ICCB6_000227 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](C(C)C)N1C(=O)CCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K08 compound treatment 1.20126E7 1050000.0 0.59 1.351592E7 1480000.0 0.83 1.486296E7 2682710.9677419 1.57522043650479 1.7302 0.922 2065790 ICCB6_000228 COc1cc(/C=C/CN[C@H](C)[C@@H](O)c2ccccc2)ccc1O[Si](C(C)C)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K09 compound treatment 1.148984E7 526000.0 0.3 1.280248E7 765000.0 0.43 1.286976E7 689510.967741899 0.404863505849627 0.6531 0.9882 2065791 ICCB6_000229 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](CC(C)C)N1C(=O)Cc4ccc(OC)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K10 compound treatment 1.234016E7 1380000.0 0.77 1.359416E7 1560000.0 0.88 1.487308E7 2692830.9677419 1.58116264608648 1.8652 0.9487 2065792 ICCB6_000230 CC(C)[Si](OCC1CCC=CC1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K11 compound treatment 8121280.0 -2840000.0 -1.6 9211760.0 -2830000.0 -1.59 8926840.0 -3253409.0322581 -1.91031999255437 -2.943 -0.9962 1034979 ICCB6_000231 c1c(cn2ccccc12)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K12 compound treatment 1.1625E7 661000.0 0.37 1.36636E7 1630000.0 0.92 1.42592E7 2078950.9677419 1.2207077431211 1.4478 0.9219 2065793 ICCB6_000232 CC1(C)COC(=O)C1OC(=O)C2CC3CCC2C=C3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K13 compound treatment 7855880.0 -3110000.0 -1.75 1.081932E7 -1220000.0 -0.69 1.050688E7 -1673369.0322581 -0.982560226995276 -1.9709 -0.9309 1952379 ICCB6_000233 CC(C)[Si](OCc1ccc(C=O)o1)(C(C)C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K14 compound treatment 1.26974E7 1730000.0 0.97 1.434336E7 2310000.0 1.3 1.408788E7 1907630.9677419 1.12011294613142 1.9584 0.9932 2065794 ICCB6_000234 OCC1CC2CCC1C=C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K15 compound treatment 1.162292E7 659000.0 0.37 1.263208E7 595000.0 0.33 1.324352E7 1063270.9677419 0.624325981467564 0.7675 0.9602 1952707 ICCB6_000235 CCCCSc1cc(=O)oc2cc(OC)ccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K16 compound treatment 432040.0 -1.05E7 -5.92 564320.0 -1.15E7 -6.46 302360.0 -1.18778890322581E7 -6.97439782784275 -11.1706 -0.9978 2065795 ICCB6_000236 Ic1ccc2NC(=O)/C(=C/C(=O)OCC=C)/c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K17 compound treatment 6447000.0 -4520000.0 -2.54 9459280.0 -2580000.0 -1.45 9007280.0 -3172969.0322581 -1.86308764682795 -3.3782 -0.9747 1952828 ICCB6_000237 CCc1cc(OC)c(O)c(C#CC(O)c2ccccc2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K18 compound treatment 1.216664E7 1200000.0 0.68 1.377844E7 1740000.0 0.98 1.289144E7 711190.967741899 0.417593456811199 1.1971 0.9489 2065796 ICCB6_000238 C=CCOC(=O)[C@H]1[C@H]2N([C@@H](c3cccnc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K19 compound treatment 1.133576E7 372000.0 0.21 1.317376E7 1140000.0 0.64 1.286224E7 681990.967741899 0.400447950903547 0.7212 0.921 1952608 ICCB6_000239 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCCc3ccccc3OC)O2)O1)OC(=O)NCc4cccc5ccccc45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K20 compound treatment 1.078704E7 -177000.0 -0.1 1.242548E7 388000.0 0.22 1.216876E7 -11489.0322581008 -0.0067460709059748 0.065 0.2708 2065797 ICCB6_000240 C=CCOC(=O)[C@H]1[C@H]2N([C@@H](c3ccco3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K21 compound treatment 1.05546E7 -409000.0 -0.23 1.178264E7 -255000.0 -0.14 1.235864E7 178390.967741899 0.104746691482547 -0.1549 -0.5336 3005761 ICCB6_000241 Cc1ccc(cc1)S(=O)(=O)O.Cc1cc(=O)oc2ccc(Cl)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K22 compound treatment 5893520.0 -5070000.0 -2.85 6015200.0 -6020000.0 -3.39 5114280.0 -7065969.0322581 -4.14895937622817 -5.9967 -0.9883 2065798 ICCB6_000242 Ic1ccc2NC(=O)/C(=C/C#N)/c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K23 mock treatment 1.10856E7 122000.0 0.07 1.277248E7 735000.0 0.41 1.284828E7 668030.967741899 0.392250989860026 0.5049 0.8793 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 K24 mock treatment 1.086932E7 -94200.0 -0.05 1.17202E7 -317000.0 -0.18 1.179004E7 -390209.032258101 -0.229120933828773 -0.2659 -0.9006 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L01 compound treatment 9851000.0 -1110000.0 -0.62 1.119712E7 -840000.0 -0.47 1.105972E7 -1120529.0322581 -0.657946477475209 -1.0137 -0.9907 2065799 ICCB6_000243 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccccc4)C(=O)N(C(=O)C)c5ccccc52 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L02 compound treatment 1.187152E7 908000.0 0.51 1.335316E7 1320000.0 0.74 1.433536E7 2155110.9677419 1.26542698044736 1.4527 0.9357 2065800 ICCB6_000244 CON(C)C(=O)[C@H]1C2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#Cc6ccccc6F)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L03 compound treatment 1.188272E7 919000.0 0.52 1.299112E7 954000.0 0.54 1.302432E7 844070.967741899 0.495617252188209 0.8942 0.9995 2065801 ICCB6_000245 COC(=O)C(C(c1ccco1)[Si](C)(C)c2ccccc2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L04 compound treatment 1.12148E7 251000.0 0.14 1.280376E7 766000.0 0.43 1.238648E7 206230.967741899 0.121093639580801 0.4005 0.8525 2065802 ICCB6_000246 CCCCC[C@H](O)C#Cc1ccc2NC(=O)[C@@]3([C@H](C4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N(C)OC)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L05 compound treatment 1.177008E7 807000.0 0.45 1.328532E7 1250000.0 0.7 1.27056E7 525350.967741899 0.308472880856475 0.8452 0.9486 2065803 ICCB6_000247 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)CN1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L06 compound treatment 1.220536E7 1240000.0 0.7 1.347688E7 1440000.0 0.81 1.310356E7 923310.967741899 0.542144988082808 1.1835 0.9873 2065804 ICCB6_000248 CON(C)C(=O)[C@H]1C2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCN(C)[C@H](C)Cc6ccccc6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L07 compound treatment 1.258568E7 1620000.0 0.91 1.277108E7 734000.0 0.41 1.229668E7 116430.967741899 0.0683653371661745 0.8039 0.8018 2065805 ICCB6_000249 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C(C)C)N1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L08 compound treatment 1.167496E7 711000.0 0.4 1.320828E7 1170000.0 0.66 1.316408E7 983830.967741899 0.577680810600995 0.9448 0.9808 2065806 ICCB6_000250 OCCOc1ccc(cc1)C2N3[C@@H]([C@@H](C(=O)OCC=C)[C@]24C(=O)Nc5ccc(Br)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L09 compound treatment 1.136484E7 401000.0 0.23 1.341912E7 1380000.0 0.78 1.355468E7 1374430.9677419 0.807031310858824 1.0451 0.9142 2065807 ICCB6_000251 CCOC(=O)CC1[C@@H]2[C@@H](NCc3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](Cc5ccccc5)N1C(=O)CCc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L10 compound treatment 1.227608E7 1310000.0 0.74 1.441624E7 2380000.0 1.34 1.39038E7 1723550.9677419 1.01202579793003 1.783 0.9726 2065808 ICCB6_000252 CON(C)C(=O)[C@H]1[C@H]2N(C(c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(I)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L11 compound treatment 1.304056E7 2080000.0 1.17 1.436036E7 2320000.0 1.31 1.371168E7 1531430.9677419 0.899217763855443 1.9477 0.9888 2065809 ICCB6_000253 COC(=O)Cc1cn[nH]c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L12 compound treatment 1.203092E7 1070000.0 0.6 1.281764E7 780000.0 0.44 1.380264E7 1622390.9677419 0.952627189107496 1.1497 0.9516 2065810 ICCB6_000254 CCOC(=O)[C@H]1[C@H]2N(C(c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(Br)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L13 compound treatment 1.345572E7 2490000.0 1.4 1.48274E7 2790000.0 1.57 1.398368E7 1803430.9677419 1.05892932573493 2.3263 0.9877 1952411 ICCB6_000255 CC(C)[Si](OCc1ccc(o1)[C@@H](O)[C@H](C)C(=O)N2[C@@H](C)[C@H](OC2=O)c3ccccc3)(C(C)C)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L14 compound treatment 1.192888E7 965000.0 0.54 1.338704E7 1350000.0 0.76 1.279184E7 611590.967741899 0.359110840770032 0.959 0.9589 2065811 ICCB6_000256 OCCOc1ccc(cc1)C2N3[C@H]([C@H](C(=O)OCC=C)[C@@]24C(=O)Nc5ccc(Br)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L15 compound treatment 1.170952E7 746000.0 0.42 1.323768E7 1200000.0 0.68 1.358784E7 1407590.9677419 0.826502029211486 1.1092 0.9672 1952793 ICCB6_000257 FC(F)(F)c1ccc(cc1)C(=O)Oc2ccccc2C#Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L16 compound treatment 1.166304E7 699000.0 0.39 1.273E7 693000.0 0.39 1.291156E7 731310.967741899 0.429407414991402 0.6998 0.999 2065812 ICCB6_000258 CON(C)C(=O)[C@H]1C2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L17 compound treatment 1.192E7 956000.0 0.54 1.41278E7 2090000.0 1.18 1.3996E7 1815750.9677419 1.0661633200083 1.6051 0.9575 1952829 ICCB6_000259 O=C(/C(=C\c1ccccc1)/c2cccc(c2)S(=O)=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L18 compound treatment 1.097808E7 14500.0 0.01 1.166808E7 -369000.0 -0.21 1.284212E7 661870.967741899 0.388633992723344 0.1091 0.2474 2065813 ICCB6_000260 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)OCC=C)[C@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L19 compound treatment 1.251096E7 1550000.0 0.87 1.374388E7 1710000.0 0.96 1.358928E7 1409030.9677419 0.827347561009671 1.5341 0.998 1952582 ICCB6_000261 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)CC[C@@H]2C[C@H](C[C@@]3(CCC[C@H](COC(=O)NCCOC)O3)O2)OC(=O)NCc4cccc5ccccc45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L20 compound treatment 1.083396E7 -130000.0 -0.07 1.20948E7 57400.0 0.03 1.213008E7 -50169.0322581008 -0.0294579944850143 -0.0404 -0.4756 2065814 ICCB6_000262 CON(C)C(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(Br)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L21 compound treatment 1.180048E7 837000.0 0.47 1.228896E7 252000.0 0.14 1.318836E7 1008110.9677419 0.591937416198179 0.6949 0.9036 1952748 ICCB6_000263 O=Cc1cccc(c1)c2cc(=O)oc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L22 compound treatment 1.026164E7 -702000.0 -0.39 1.055308E7 -1480000.0 -0.84 1.129204E7 -888209.032258101 -0.521534014034608 -1.0111 -0.9531 2065815 ICCB6_000264 CON(C)C(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCC6CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L23 mock treatment 1.115828E7 195000.0 0.11 1.24816E7 444000.0 0.25 1.248156E7 301310.967741899 0.176922225255441 0.3097 0.9521 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 L24 mock treatment 1.141432E7 451000.0 0.25 1.22052E7 168000.0 0.09 1.165416E7 -526089.032258101 -0.308906253785337 0.0224 0.0545 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M01 compound treatment 6465520.0 -4500000.0 -2.53 7024120.0 -5010000.0 -2.82 8651600.0 -3528649.0322581 -2.07193400097977 -4.2842 -0.9923 2065816 ICCB6_000265 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccccc3)c4ccccc4)C(=O)N(C(=O)C)c5ccc(Cl)cc52 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M02 compound treatment 1.11482E7 185000.0 0.1 1.250448E7 467000.0 0.26 1.205148E7 -128769.032258101 -0.0756099384693086 0.168 0.5743 2065817 ICCB6_000266 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C#N)[C@@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M03 compound treatment 1.166264E7 699000.0 0.39 1.304004E7 1000000.0 0.56 1.26796E7 499350.967741899 0.293206334500347 0.7218 0.9657 2065818 ICCB6_000267 COc1ccc(cc1)C(CC(=O)c2ccccc2)[Si](C)(C)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M04 compound treatment 1.1945E7 981000.0 0.55 1.285516E7 818000.0 0.46 1.259536E7 415110.967741899 0.243742724306493 0.7248 0.9556 2065819 ICCB6_000268 OCc1ccc(o1)[C@@H]2N3[C@H]([C@H](C#N)[C@@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M05 compound treatment 1.122212E7 259000.0 0.15 1.22664E7 229000.0 0.13 1.283464E7 654390.967741899 0.384241924771658 0.3801 0.8829 2065820 ICCB6_000269 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)CN1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M06 compound treatment 1.07858E7 -178000.0 -0.1 1.222116E7 184000.0 0.1 1.244384E7 263590.967741899 0.154773989541858 0.0914 0.4329 2065821 ICCB6_000270 COC(=O)/C=C\1/C(=O)Nc2ccc(I)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M07 compound treatment 1.180396E7 840000.0 0.47 1.37996E7 1760000.0 0.99 1.28774E7 697150.967741899 0.40934952177889 1.0816 0.9226 2065822 ICCB6_000271 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C(C)C)N1C(=O)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M08 compound treatment 1.179824E7 835000.0 0.47 1.315372E7 1120000.0 0.63 1.21894E7 9150.96774189919 0.00537321820135135 0.6366 0.8119 2065823 ICCB6_000272 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCC4)[C@]25C(=O)Nc6ccc(I)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M09 compound treatment 1.153644E7 573000.0 0.32 1.251164E7 474000.0 0.27 1.32116E7 1031350.9677419 0.605583359941118 0.6895 0.937 2065824 ICCB6_000273 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](Cc4ccccc4)N1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M10 compound treatment 1.159872E7 635000.0 0.36 1.220096E7 164000.0 0.09 1.275568E7 575430.967741899 0.337878597837817 0.4542 0.9086 2065825 ICCB6_000274 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCc4ccccc4)[C@]25C(=O)Nc6ccc(I)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M11 compound treatment 1.293472E7 1970000.0 1.11 1.444312E7 2410000.0 1.35 1.38646E7 1684350.9677419 0.989008543423869 1.9921 0.9914 2065826 ICCB6_000275 CC(C(=O)O)c1ccccc1C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M12 compound treatment 1.211244E7 1150000.0 0.65 1.358344E7 1550000.0 0.87 1.332524E7 1144990.9677419 0.672309911014594 1.2632 0.9907 2065827 ICCB6_000276 OCCNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(I)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M13 compound treatment 1.363716E7 2670000.0 1.5 1.483804E7 2800000.0 1.58 1.38686E7 1688350.9677419 0.991357242863273 2.3496 0.9821 1952416 ICCB6_000277 Clc1c(Cl)c(Cl)c(OCc2ccccc2)c(Cl)c1Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M14 compound treatment 1.192524E7 962000.0 0.54 1.303504E7 998000.0 0.56 1.350724E7 1326990.9677419 0.779175735507489 1.086 0.9855 2065828 ICCB6_000278 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M15 compound treatment 1.294296E7 1980000.0 1.11 1.458704E7 2550000.0 1.44 1.325352E7 1073270.9677419 0.630197730066075 1.8344 0.9545 1952795 ICCB6_000279 COC(=O)/C=C/c1cc(OC)cc(C#Cc2ccc(Oc3ccccc3)c(OC)c2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M16 compound treatment 1.157344E7 610000.0 0.34 1.377668E7 1740000.0 0.98 1.322448E7 1044230.9677419 0.613146172136 1.117 0.9271 2065829 ICCB6_000280 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)C(C(OC3=O)c5ccccc5)c6ccccc6)C(=O)N(C)OC)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M17 compound treatment 1.220388E7 1240000.0 0.7 1.384644E7 1810000.0 1.02 1.37094E7 1529150.9677419 0.897879005174982 1.5085 0.9886 1952832 ICCB6_000281 CCc1cc(OC)c(O)c(C#CC(C)(O)C=C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M18 compound treatment 1.167732E7 714000.0 0.4 1.26074E7 570000.0 0.32 1.299712E7 816870.967741899 0.47964609600026 0.6936 0.9871 3176523 ICCB6_000282 CON(C)C(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)N(C(=O)OCC(C)C)c5ccc(C#CC6(O)CCCCCC6)cc54)C(C(OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M19 compound treatment 1.11384E7 175000.0 0.1 1.195892E7 -78500.0 -0.04 1.215252E7 -27729.0322581008 -0.0162817906299562 0.0218 0.2001 1952627 ICCB6_000283 CCOC(=O)[C@H](CC(C)C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCCC(C)C)O2)O1)OC(=O)NCc3ccc4OCOc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M20 compound treatment 1.202216E7 1060000.0 0.59 1.305716E7 1020000.0 0.57 1.315704E7 976790.967741899 0.573547099587644 1.0058 0.9999 3056713 ICCB6_000284 CON(C)C(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)N(C(=O)N[C@@H](C(C)C)C(=O)OC)c5ccc(C#CC6(O)CCCCCC6)cc54)C(C(OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M21 compound treatment 1.055344E7 -410000.0 -0.23 1.102608E7 -1010000.0 -0.57 1.124E7 -940249.032258101 -0.552090593741257 -0.7804 -0.945 1107217 ICCB6_000285 Cc1cccnc1I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M22 compound treatment 1.074916E7 -214000.0 -0.12 1.157912E7 -458000.0 -0.26 1.1747E7 -433249.032258101 -0.254392939796763 -0.3653 -0.9569 3176524 ICCB6_000286 CON(C)C(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)N(C(=O)N[C@H](C)c5ccccc5)c6ccc(C#CC7(O)CCCCCC7)cc64)C(C(OC2=O)c8ccccc8)c9ccccc9 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M23 mock treatment 1.11586E7 195000.0 0.11 1.22024E7 165000.0 0.09 1.250856E7 328310.967741899 0.19277594647142 0.2282 0.9492 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 M24 mock treatment 1.0305E7 -659000.0 -0.37 1.140572E7 -632000.0 -0.36 1.186004E7 -320209.032258101 -0.188018693639198 -0.5274 -0.9651 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N01 compound treatment 1.1784E7 820000.0 0.46 1.292976E7 892000.0 0.5 1.671552E7 4535270.9677419 2.66299709487049 2.0936 0.7616 2065830 ICCB6_000287 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3ccc(Cl)cc3)c4ccccc4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N02 compound treatment 1.449084E7 3530000.0 1.98 1.398956E7 1950000.0 1.1 1.421604E7 2035790.9677419 1.19536527616993 2.4684 0.9636 2065831 ICCB6_000288 CON(C)C(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCN(C)Cc6ccccc6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N03 compound treatment 1.122836E7 265000.0 0.15 1.349568E7 1460000.0 0.82 1.376532E7 1585070.9677419 0.930713823337854 1.0972 0.8778 2065832 ICCB6_000289 C[Si](C)(F)C(CC(=O)c1ccccc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N04 compound treatment 1.5284E7 4320000.0 2.43 1.452848E7 2490000.0 1.4 1.419532E7 2015070.9677419 1.18319901307382 2.8938 0.9512 2065833 ICCB6_000290 CCCCOc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N(C)OC)c3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N05 compound treatment 1.231836E7 1350000.0 0.76 1.447384E7 2440000.0 1.37 1.308056E7 900310.967741899 0.528639966306234 1.5364 0.9282 2065834 ICCB6_000291 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)CN1C(=O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N06 compound treatment 1.611892E7 5160000.0 2.9 1.84324E7 6390000.0 3.6 1.415404E7 1973790.9677419 1.15896043485916 4.4193 0.9278 2065835 ICCB6_000292 CC1(C)N[C@H](Cc2c[nH]c3ccccc23)[C@@H]4CC1CCC4=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N07 compound treatment 1.57502E7 4790000.0 2.69 1.752028E7 5480000.0 3.09 1.34594E7 1279150.9677419 0.751085290212214 3.7678 0.9054 2065836 ICCB6_000293 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)[C@H](C(C)C)N1C(=O)Cc4ccc(OC)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N08 compound treatment 1.19514E7 988000.0 0.55 1.33534E7 1320000.0 0.74 1.308024E7 899990.967741899 0.528452070351081 1.0531 0.9881 2065837 ICCB6_000294 CN1[C@H](Cc2c[nH]c3ccccc23)[C@@H]4CC(CCC4=C)C1(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N09 compound treatment 1.271952E7 1760000.0 0.99 1.309808E7 1060000.0 0.6 1.388712E7 1706870.9677419 1.00223172126772 1.4928 0.9772 2065838 ICCB6_000295 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](Cc5ccccc5)N1C(=O)CCc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N10 compound treatment 1.365032E7 2690000.0 1.51 1.477964E7 2740000.0 1.54 1.436676E7 2186510.9677419 1.28386427104668 2.5037 0.9968 2065839 ICCB6_000296 Cc1ccc(cc1)S(=O)(=O)N[C@H]2CC3CCC2(C)C3(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N11 compound treatment 1.430776E7 3340000.0 1.88 1.523412E7 3200000.0 1.8 1.400304E7 1822790.9677419 1.07029703102165 2.7413 0.9746 2065840 ICCB6_000297 CCOC(=O)CC(CC(=O)OCC)(C(=O)OCC)c1cccnc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N12 compound treatment 1.832312E7 7360000.0 4.13 1.689888E7 4860000.0 2.74 1.451876E7 2338510.9677419 1.37311484974405 4.7593 0.9252 2065841 ICCB6_000298 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCC6CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N13 compound treatment 1.446424E7 3500000.0 1.97 1.451824E7 2480000.0 1.4 1.350356E7 1323310.9677419 0.777014932023237 2.3901 0.9433 1952445 ICCB6_000299 Clc1ccc2oc(nc2c1)c3ccc(NC(=O)c4ccc(CNC(=O)OCc5ccccc5)cc4)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N14 compound treatment 1.2698E7 1730000.0 0.97 1.698596E7 4950000.0 2.79 1.485896E7 2678710.9677419 1.57287173706538 3.0788 0.9207 2065842 ICCB6_000300 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N15 compound treatment 1.299324E7 2030000.0 1.14 1.39656E7 1930000.0 1.09 1.403348E7 1853230.9677419 1.08817063375552 1.9131 0.9997 1952801 ICCB6_000301 Oc1ccccc1C#Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N16 compound treatment 1.294712E7 1980000.0 1.11 1.375964E7 1720000.0 0.97 1.336872E7 1188470.9677419 0.697840273920919 1.6059 0.9831 2065843 ICCB6_000302 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N17 compound treatment 7974160.0 -2990000.0 -1.68 8367880.0 -3670000.0 -2.07 7074320.0 -5105929.0322581 -2.99807316392568 -3.8929 -0.971 1952836 ICCB6_000303 CC(=O)c1ccc2oc(cc2c1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N18 compound treatment 1.1912E7 948000.0 0.53 1.347736E7 1440000.0 0.81 1.383228E7 1652030.9677419 0.970031051953482 1.3356 0.9736 2065844 ICCB6_000304 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N19 compound treatment 1.247024E7 1510000.0 0.85 1.397116E7 1930000.0 1.09 1.376772E7 1587470.9677419 0.932123043001497 1.6552 0.9945 1952631 ICCB6_000305 CCOC(=O)[C@H](CC(C)C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCc3cccc(c3)C(F)(F)F)O2)O1)OC(=O)NCc4ccc5OCOc5c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N20 compound treatment 1.317616E7 2210000.0 1.24 1.51766E7 3140000.0 1.77 1.333832E7 1158070.9677419 0.679990158181446 2.1303 0.9406 2065845 ICCB6_000306 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N21 compound treatment 1.298132E7 2020000.0 1.13 1.506548E7 3030000.0 1.7 1.32192E7 1038950.9677419 0.610045888875986 1.9907 0.932 3005761 ICCB6_000307 Cc1ccc(cc1)S(=O)(=O)O.Cc1cc(=O)oc2ccc(Cl)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N22 compound treatment 1.181028E7 847000.0 0.48 1.292128E7 884000.0 0.5 1.266028E7 480030.967741899 0.281862116208025 0.7246 0.9742 2065846 ICCB6_000308 CN(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)Cc8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N23 mock treatment 1.24518E7 1490000.0 0.84 1.33728E7 1340000.0 0.75 1.30458E7 865550.967741899 0.50822976817781 1.21 0.9808 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 N24 mock treatment 1.20816E7 1120000.0 0.63 1.138164E7 -656000.0 -0.37 1.139436E7 -785889.032258101 -0.461454282374646 -0.117 -0.1356 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O01 compound treatment 1.068276E7 -281000.0 -0.16 1.147252E7 -565000.0 -0.32 1.386396E7 1683710.9677419 0.988632751513564 0.2961 0.2819 2065847 ICCB6_000309 CCOC(=O)[C@@H]1[C@@H](C(=O)OC)[C@@]2([C@H](N1c3cccc(F)c3)c4ccccc4)C(=O)N(Cc5ccccc5)c6ccccc62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O02 compound treatment 1.51178E7 4150000.0 2.33 1.701192E7 4970000.0 2.8 1.318556E7 1005310.9677419 0.590293326590596 3.3047 0.895 3176588 ICCB6_000310 CON(C)C(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)N(C(=O)NCc5ccc(Cl)c(Cl)c5)c6ccc(C#CC7(O)CCCCCC7)cc64)C(C(OC2=O)c8ccccc8)c9ccccc9 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O03 compound treatment 1.268304E7 1720000.0 0.97 1.498584E7 2950000.0 1.66 1.3207E7 1026750.9677419 0.602882355585803 1.8639 0.9261 2065848 ICCB6_000311 Cc1ccc(cc1)c2c(cc(c3ccccc3)n2c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O04 compound treatment 1.16168E7 653000.0 0.37 1.284944E7 812000.0 0.46 1.295892E7 778670.967741899 0.457216016353949 0.7397 0.9951 3176589 ICCB6_000312 CON(C)C(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)N(C(=O)OCc5ccc(cc5)[N+](=O)[O-])c6ccc(C#CC7(O)CCCCCC7)cc64)C(C(OC2=O)c8ccccc8)c9ccccc9 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O05 compound treatment 1.084204E7 -122000.0 -0.07 1.213048E7 93100.0 0.05 1.214792E7 -32329.0322581008 -0.0189827949852712 -0.0201 -0.2283 2065849 ICCB6_000313 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)CN1C(=O)CCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O06 compound treatment 1.292192E7 1960000.0 1.1 1.39274E7 1890000.0 1.06 1.306484E7 884590.967741899 0.519409577509375 1.5492 0.9586 2065850 ICCB6_000314 COc1cc(C[C@@H]2[C@@H]3CC(CCC3=C)C(C)(C)N2N=Nc4ccc(Br)cc4)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O07 compound treatment 1.392824E7 2960000.0 1.67 1.59522E7 3910000.0 2.2 1.258544E7 405190.967741899 0.23791794969677 2.3711 0.8553 2065851 ICCB6_000315 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C(C)C)N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O08 compound treatment 1.17392E7 776000.0 0.44 1.337364E7 1340000.0 0.75 1.385944E7 1679190.9677419 0.985978721147037 1.2551 0.9548 2065852 ICCB6_000316 COc1cc(C[C@@H]2[C@@H]3CC(CCC3=C)C(C)(C)N2N=Nc4ccc(cc4)[N+](=O)[O-])cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O09 compound treatment 1.557516E7 4610000.0 2.59 1.334256E7 1310000.0 0.73 1.337884E7 1198590.9677419 0.703782483502612 2.326 0.8358 2065853 ICCB6_000317 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccc(OC)c(OC)c3)c4cc(OCCCO)ccc4N2C(=O)[C@H](Cc5ccccc5)N1C(=O)Cc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O10 compound treatment 1.653604E7 5570000.0 3.13 1.39078E7 1870000.0 1.05 1.40336E7 1853350.9677419 1.0882410947387 3.0433 0.8753 2065854 ICCB6_000318 CC(C)C[C@@H]1[C@@H]2CC(CCC2=C)C(C)(C)N1N=Nc3ccc(Br)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O11 compound treatment 1.264104E7 1680000.0 0.94 1.379552E7 1760000.0 0.99 1.380164E7 1621390.9677419 0.952040014247645 1.665 0.9998 2065855 ICCB6_000319 CCOC(=O)CC(C(=O)OCC)c1cccnc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O12 compound treatment 1.50868E7 4120000.0 2.32 1.400576E7 1970000.0 1.11 1.354628E7 1366030.9677419 0.802099042036075 2.4399 0.9071 2065856 ICCB6_000320 CC(C)C[C@@H]1[C@@H]2CC(CCC2=C)C(C)(C)N1N=Nc3ccc(cc3)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O13 compound treatment 1.552984E7 4570000.0 2.56 1.310192E7 1060000.0 0.6 1.433156E7 2151310.9677419 1.26319571597993 2.5561 0.875 1952450 ICCB6_000321 CCOC(=O)C(O)C(O)c1ccc(CO[Si](C(C)C)(C(C)C)c2ccccc2)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O14 compound treatment 1.169856E7 735000.0 0.41 1.44568E7 2420000.0 1.36 1.43188E7 2138550.9677419 1.25570336476823 1.7496 0.9219 2065857 ICCB6_000322 C[C@@H]1[C@@H]2CC(CCC2=C)C(C)(C)N1N=Nc3ccc(Br)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O15 compound treatment 1.236768E7 1400000.0 0.79 1.356924E7 1530000.0 0.86 1.354804E7 1367790.9677419 0.803132469789413 1.4169 0.9992 1952761 ICCB6_000323 COc1ccc(cc1)C(=C2C(=O)Oc3ccccc23)c4ccc(OC)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O16 compound treatment 1.30364E7 2070000.0 1.16 1.407988E7 2040000.0 1.15 1.361264E7 1432390.9677419 0.841063965735793 1.8216 0.9901 2065858 ICCB6_000324 C[C@@H]1[C@@H]2CC(CCC2=C)C(C)(C)N1N=Nc3ccc(cc3)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O17 compound treatment 1.568184E7 4720000.0 2.65 1.296444E7 927000.0 0.52 1.277428E7 594030.967741899 0.348800050231047 2.0327 0.7464 1952837 ICCB6_000325 COCCNC(=O)c1ccc(c(C#CC(C)(O)CC(C)C)c1O)c2cc(F)cc(F)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O18 compound treatment 1.081172E7 -152000.0 -0.09 1.108E7 -957000.0 -0.54 1.106268E7 -1117569.0322581 -0.65620843989005 -0.7392 -0.8662 2065859 ICCB6_000326 CO[C@H]1O[C@@H]2COC(O[C@H]2[C@H](OC(=O)/C=C/C=C/C)[C@H]1OC(=O)/C=C/C=C/C)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O19 compound treatment 1.20594E7 1100000.0 0.62 1.370904E7 1670000.0 0.94 1.376288E7 1582630.9677419 0.929281116679818 1.4352 0.9839 1952633 ICCB6_000327 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCc3ccccc3)O2)O1)OC(=O)NCc4ccc5OCOc5c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O20 compound treatment 1.202972E7 1070000.0 0.6 1.35016E7 1460000.0 0.82 1.288572E7 705470.967741899 0.414234816612851 1.0608 0.9645 2065860 ICCB6_000328 CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](COC(c2ccccc2)(c3ccccc3)c4ccccc4)O[C@H](CC=C)[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1N=[N+]=[N-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O21 compound treatment 1.157552E7 612000.0 0.34 1.255576E7 518000.0 0.29 1.235464E7 174390.967741899 0.102397992043143 0.426 0.9214 1952755 ICCB6_000329 C=C(c1ccccc1)c2cc(=O)oc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O22 compound treatment 1.138136E7 418000.0 0.23 1.21114E7 74000.0 0.04 1.202964E7 -150609.032258101 -0.0884338374084561 0.1085 0.4267 2065861 ICCB6_000330 C[C@H]1[C@H](OC(=O)N1C(=O)[C@@H](CC=C)C(C)(C)C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O23 mock treatment 1.134332E7 380000.0 0.21 1.180976E7 -228000.0 -0.13 1.197868E7 -201569.032258101 -0.118356268266467 -0.0192 -0.0695 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 O24 mock treatment 1.069408E7 -269000.0 -0.15 1.051792E7 -1520000.0 -0.86 1.087084E7 -1309409.0322581 -0.768852065003879 -1.0251 -0.8837 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P01 compound treatment 9513800.0 -1450000.0 -0.81 1.009532E7 -1940000.0 -1.09 1.03932E7 -1787049.0322581 -1.04931026506315 -1.7071 -0.9924 2065862 ICCB6_000331 CC1(C)OCC2=C(CC(CCc3ccccc3)OC2CCc4ccccc4)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P02 compound treatment 1.166448E7 701000.0 0.39 1.229988E7 262000.0 0.15 1.206672E7 -113529.032258101 -0.0666613936051783 0.2741 0.6438 2065863 ICCB6_000332 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(I)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P03 compound treatment 1.178624E7 823000.0 0.46 1.185164E7 -186000.0 -0.1 1.305264E7 872390.967741899 0.512246044219192 0.5022 0.7197 2065864 ICCB6_000333 C1CCC(CC1)c2c(cc(c3ccccc3)n2c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P04 compound treatment 1.216736E7 1200000.0 0.68 1.285932E7 822000.0 0.46 1.232024E7 139990.967741899 0.0821991768642657 0.705 0.8561 2065865 ICCB6_000334 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P05 compound treatment 1.166792E7 704000.0 0.4 1.302604E7 989000.0 0.56 1.19276E7 -252649.032258101 -0.14834916010766 0.4641 0.6642 2065866 ICCB6_000335 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)C(C)C)c3cc(OCCCO)ccc3N2C(=O)CN1C(=O)Cc4ccc(OC)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P06 compound treatment 1.205444E7 1090000.0 0.61 1.325864E7 1220000.0 0.69 1.271632E7 536070.967741899 0.314767395354079 0.9324 0.9581 2065867 ICCB6_000336 CCCCOc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P07 compound treatment 1.123752E7 274000.0 0.15 1.234116E7 304000.0 0.17 1.255556E7 375310.967741899 0.22037316488442 0.3148 0.9882 2065868 ICCB6_000337 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](C(C)C)N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P08 compound treatment 1.2122E7 1160000.0 0.65 1.333608E7 1300000.0 0.73 1.224588E7 65630.9677418992 0.03853685428574 0.82 0.8372 2065869 ICCB6_000338 C[C@H](Cc1ccccc1)N(C)CC#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P09 compound treatment 1.177572E7 812000.0 0.46 1.289448E7 857000.0 0.48 1.271352E7 533270.967741899 0.313123305746496 0.7227 0.9845 2065870 ICCB6_000339 CCOC(=O)CC1[C@@H]2[C@@H](NC(=O)c3ccccc3)c4cc(OCCCO)ccc4N2C(=O)[C@H](Cc5ccccc5)N1C(=O)Cc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P10 compound treatment 1.179748E7 834000.0 0.47 1.042852E7 -1610000.0 -0.91 1.293256E7 752310.967741899 0.441738087048275 0.0026 0.0023 2065871 ICCB6_000340 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P11 compound treatment 404680.0 -1.06E7 -5.93 4100400.0 -7940000.0 -4.47 4439760.0 -7740489.0322581 -4.54502056269492 -8.6277 -0.991 2065872 ICCB6_000341 CCOC(=O)/C(=C/1\NSc2ccccc12)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P12 compound treatment 1.204884E7 1090000.0 0.61 1.290476E7 867000.0 0.49 1.257344E7 393190.967741899 0.230871851378557 0.7671 0.9419 2065873 ICCB6_000342 CCOC(OCC)C#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P13 compound treatment 9528360.0 -1440000.0 -0.81 1.1233E7 -804000.0 -0.45 1.02938E7 -1886449.0322581 -1.10767544613234 -1.3664 -0.947 2065874 ICCB6_000343 COC(=O)C(C(=O)OC)c1ccc(cc1I)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P14 compound treatment 982400.0 -9980000.0 -5.61 459080.0 -1.16E7 -6.52 240680.0 -1.19395690322581E7 -7.01061477319836 -11.0472 -0.9959 2065875 ICCB6_000344 Brc1ccc2NC(=O)/C(=C/C(=O)OCC=C)/c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P15 compound treatment 1.162844E7 665000.0 0.37 1.294732E7 910000.0 0.51 1.307392E7 893670.967741899 0.524741125236822 0.8143 0.9895 1952804 ICCB6_000345 COc1cc(CO[Si](C)(C)C(C)(C)C)cc(C#CC2(O)CCCCC2)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P16 compound treatment 972960.0 -9990000.0 -5.61 8546200.0 -3490000.0 -1.97 2429280.0 -9750969.0322581 -5.7255238749283 -7.6801 -0.9304 2065876 ICCB6_000346 CCOC(=O)/C=C\1/C(=O)Nc2ccc(Br)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P17 compound treatment 1.130888E7 345000.0 0.19 1.2863E7 826000.0 0.46 1.142632E7 -753929.032258101 -0.442688173853805 0.1247 0.186 1952838 ICCB6_000347 COc1cc(CO[Si](C)(C)C(C)(C)C)cc(C#CC2(O)CCC3C2CC4Cc5cc(O)ccc5C43)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P18 compound treatment 502720.0 -1.05E7 -5.88 526840.0 -1.15E7 -6.48 410120.0 -1.17701290322581E7 -6.9111238649452 -11.1233 -0.9978 2065877 ICCB6_000348 O=C(/C=C\1/C(=O)Nc2ccccc12)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P19 compound treatment 1.069388E7 -270000.0 -0.15 1.175488E7 -283000.0 -0.16 1.14686E7 -711649.032258101 -0.417862420779302 -0.4205 -0.8908 1952634 ICCB6_000349 COC(=O)[C@H](C)NC(=O)CC[C@@H]1C[C@H](C[C@@]2(CCC[C@H](COC(=O)NCCOc3ccccc3)O2)O1)OC(=O)NCc4ccc5OCOc5c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P20 compound treatment 3864840.0 -7100000.0 -3.99 6155240.0 -5880000.0 -3.31 5972480.0 -6207769.0322581 -3.64504591150398 -6.3182 -0.9971 2065878 ICCB6_000350 CON(C)C(=O)/C=C\1/C(=O)Nc2ccc(Br)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P21 compound treatment 1.170196E7 738000.0 0.41 1.253892E7 502000.0 0.28 1.22098E7 29550.9677418992 0.0173515853423132 0.4125 0.8216 1952770 ICCB6_000351 O=C/1Oc2ccccc2C\C1=C(/c3ccccc3)\c4ccc5ccccc5c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P22 compound treatment 423640.0 -1.05E7 -5.92 512080.0 -1.15E7 -6.49 1643880.0 -1.05363690322581E7 -6.18669100985534 -10.7355 -0.9993 2065879 ICCB6_000352 CON(C)C(=O)/C=C\1/C(=O)Nc2ccc(I)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P23 mock treatment 1.044936E7 -514000.0 -0.29 1.055224E7 -1490000.0 -0.84 1.117924E7 -1001009.0322581 -0.587767338225809 -0.9888 -0.9311 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.1463 P24 mock treatment 9053560.0 -1910000.0 -1.07 8727960.0 -3310000.0 -1.86 9415720.0 -2764529.0322581 -1.62326194707037 -2.6321 -0.9771 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A01 compound treatment 8696960.0 -2070000.0 -1.16 9729000.0 -1480000.0 -0.84 9354200.0 -2487052.9032258 -1.46033493989381 -1.9953 -0.9763 3085008 TimTec1_004225 CC(=C)CS(=O)(=O)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A02 compound treatment 1.000568E7 -758000.0 -0.43 1.027936E7 -933000.0 -0.53 9852720.0 -1988532.9032258 -1.16761652876086 -1.2231 -0.9065 1397478 TimTec1_004226 COc1ccc(NC(=O)C2C(=C2c3ccccc3)c4ccccc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A03 compound treatment 8964200.0 -1800000.0 -1.01 9794560.0 -1420000.0 -0.8 8862360.0 -2978892.9032258 -1.74913102296297 -2.0541 -0.9457 1295145 TimTec1_004227 CCOC(=O)C1(C(CC(=O)CC1c2ccccc2)c3ccccc3)C(=O)OCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A04 compound treatment 9807000.0 -956000.0 -0.54 1.001228E7 -1200000.0 -0.68 1.013192E7 -1709332.9032258 -1.00367730789044 -1.2796 -0.9667 1717498 TimTec1_004228 CC(C)(C)C(=O)NCCc1c[nH]c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A05 compound treatment 1.108864E7 325000.0 0.18 1.130788E7 95400.0 0.05 1.132276E7 -518492.9032258 -0.304445997785385 -0.0393 -0.1093 3212224 TimTec1_004229 CC(C)(COC(=O)c1ccccc1)NC2=NS(=O)(=O)c3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A06 compound treatment 1.068744E7 -75900.0 -0.04 1.205512E7 843000.0 0.47 1.196628E7 125027.0967742 0.0734127680259774 0.2916 0.6052 1324852 TimTec1_004230 CC1CC(O)(Cc2ccc(C)cc2)C(C)CN1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A07 compound treatment 1.095744E7 194000.0 0.11 1.164784E7 435000.0 0.25 1.137444E7 -466812.9032258 -0.274100801028282 0.0462 0.1205 1528736 TimTec1_004231 COc1cccc(CC(C)C(=O)N)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A08 compound treatment 1.095612E7 193000.0 0.11 1.179544E7 583000.0 0.33 1.223848E7 397227.0967742 0.23324176487744 0.3867 0.9274 3212225 TimTec1_004232 COc1c(ccc2ccccc12)C(=O)NCCOc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A09 compound treatment 1.058344E7 -180000.0 -0.1 1.210808E7 896000.0 0.5 1.23724E7 531147.0967742 0.311876222108695 0.4128 0.6864 3212226 TimTec1_004233 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4CC(=O)CCC4(C)C3CCC21C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A10 compound treatment 8718360.0 -2040000.0 -1.15 7982880.0 -3230000.0 -1.82 9227280.0 -2613972.9032258 -1.53485917310611 -2.5989 -0.9837 1391256 TimTec1_004234 O=C(COc1cccc(OCC(=O)Nc2ccccn2)c1)Nc3ccccn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A11 compound treatment 1.140448E7 641000.0 0.36 1.174188E7 529000.0 0.3 1.20332E7 191947.0967742 0.112706509647211 0.4451 0.9256 3085079 TimTec1_004235 CN(CP(=O)(O)CN1CCCC1=O)C(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A12 compound treatment 1.067156E7 -91800.0 -0.05 1.16204E7 408000.0 0.23 1.191848E7 77227.0967742 0.0453458097250961 0.129 0.5382 1155490 TimTec1_004236 OC(=O)CN(CC(=O)O)c1ccc(Cl)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A13 compound treatment 1.110596E7 343000.0 0.19 1.209156E7 879000.0 0.49 1.225964E7 418387.0967742 0.245666384911888 0.5387 0.9207 3085081 TimTec1_004237 O/N=C/C(=O)Nc1ccccc1C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A14 compound treatment 1.009856E7 -665000.0 -0.37 1.098328E7 -229000.0 -0.13 1.146332E7 -377932.9032258 -0.221912699484718 -0.4182 -0.9229 1152383 TimTec1_004238 COc1ccc(NC(=O)C2C3C2C4CCC3C4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A15 compound treatment 1.017056E7 -593000.0 -0.33 1.094772E7 -265000.0 -0.15 1.100968E7 -831572.9032258 -0.488278702907559 -0.5602 -0.9191 1199333 TimTec1_004239 O=C(NCc1ccccc1)C2CC2(c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A16 compound treatment 312480.0 -1.05E7 -5.87 264760.0 -1.09E7 -6.16 496360.0 -1.13448929032258E7 -6.66143590047704 -10.793 -0.9986 3212227 TimTec1_004240 Cc1ccc(cc1)C(=O)CC(C(C#N)C#N)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A17 compound treatment 1.07446E7 -18700.0 -0.01 1.132684E7 114000.0 0.06 1.129596E7 -545292.9032258 -0.320182284029394 -0.1538 -0.4705 3085083 TimTec1_004241 O=c1[nH][nH]c(=O)c2c(/N=C/c3cccc4ccccc34)cccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A18 compound treatment 1.003784E7 -725000.0 -0.41 1.029412E7 -918000.0 -0.52 1.067228E7 -1168972.9032258 -0.686391500621311 -0.93 -0.9779 3212228 TimTec1_004242 COc1ccc(OC)c(NC(=O)C2C3CC/C=C/CC\C=C/CCC23)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A19 compound treatment 9232480.0 -1530000.0 -0.86 9704880.0 -1510000.0 -0.85 9568920.0 -2272332.9032258 -1.33425675398659 -1.7567 -0.976 3085086 TimTec1_004243 Brc1ccccc1NC(=O)CSc2nc3ccccc3[nH]2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A20 compound treatment 8174320.0 -2590000.0 -1.45 8643960.0 -2570000.0 -1.45 9058960.0 -2782292.9032258 -1.63369244551624 -2.6175 -0.9984 3212229 TimTec1_004244 COc1ccc(cc1)N2C(=O)C(=CC2(OC)c3ccccc3)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A21 compound treatment 9462120.0 -1300000.0 -0.73 9493640.0 -1720000.0 -0.97 9972560.0 -1868692.9032258 -1.0972494935563 -1.6141 -0.987 3085088 TimTec1_004245 CN(C)/N=C/c1ccc(OC(=O)c2ccc(Br)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A22 compound treatment 9864520.0 -899000.0 -0.5 1.011136E7 -1100000.0 -0.62 1.094784E7 -893412.9032258 -0.524589596240749 -0.9522 -0.9959 3212230 TimTec1_004246 O=C(CSc1ccccn1)N2CCCc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A23 mock treatment 9902840.0 -860000.0 -0.48 9982840.0 -1230000.0 -0.69 1.02374E7 -1603852.9032258 -0.941742103673346 -1.2224 -0.9665 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 A24 mock treatment 8520120.0 -2240000.0 -1.26 9651040.0 -1560000.0 -0.88 9828000.0 -2013252.9032258 -1.18213149129638 -1.9174 -0.9892 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B01 compound treatment 1.041724E7 -346000.0 -0.19 1.088072E7 -332000.0 -0.19 9995760.0 -1845492.9032258 -1.08362703680776 -0.8457 -0.7573 1674437 TimTec1_004247 CCN1N=C(C)C=C(C)n2c1nc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B02 compound treatment 9692320.0 -1070000.0 -0.6 1.066452E7 -548000.0 -0.31 9834000.0 -2007252.9032258 -1.17860844213727 -1.2059 -0.8875 1696382 TimTec1_004248 Cc1ccc(NC(=O)C2C3CCCCC=CC23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B03 compound treatment 1.199052E7 1230000.0 0.69 1.22278E7 1020000.0 0.57 1.218504E7 343787.0967742 0.201863140366998 0.8445 0.92 3212231 TimTec1_004249 CCC1SC(=NC1=O)Nc2ccc(C)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B04 compound treatment 1.13604E7 597000.0 0.34 1.22382E7 1030000.0 0.58 1.236076E7 519507.0967742 0.305041506740029 0.7031 0.9578 1427335 TimTec1_004250 C=CCN(CC=C)S(=O)(=O)c1ncn[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B05 compound treatment 1.124848E7 485000.0 0.27 1.229496E7 1080000.0 0.61 1.220516E7 363907.0967742 0.213677098547202 0.6325 0.9025 3085092 TimTec1_004251 Nc1cc(ccc1OCc2ccccc2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B06 compound treatment 8380080.0 -2380000.0 -1.34 1.066876E7 -544000.0 -0.31 9247200.0 -2594052.9032258 -1.52316264989788 -1.829 -0.8918 3212232 TimTec1_004252 CN(C)c1c(C(=C(C#N)C#N)C#N)c2ccccc2n1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B07 compound treatment 1.102724E7 264000.0 0.15 1.26122E7 1400000.0 0.79 1.271808E7 876827.0967742 0.514850827662014 0.8377 0.8792 3085094 TimTec1_004253 OC(=O)c1ccc(CSc2ccccn2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B08 compound treatment 1.085124E7 87900.0 0.05 1.114492E7 -67500.0 -0.04 1.180072E7 -40532.9032258 -0.0237999017709662 -0.0072 -0.1076 1347619 TimTec1_004254 CCC1NC(=S)NC(=C1C(=O)c2ccccc2)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B09 compound treatment 1.185764E7 1090000.0 0.61 1.260996E7 1400000.0 0.79 1.297856E7 1137307.0967742 0.667798135156022 1.1946 0.9946 3085159 TimTec1_004255 CCOc1ccc(cc1NC(=O)C)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B10 compound treatment 1.208288E7 1320000.0 0.74 1.2582E7 1370000.0 0.77 1.30644E7 1223147.0967742 0.718201225125638 1.2877 0.9996 1518737 TimTec1_004256 CCC(=O)N1N=C2CC(C)(C)OCC2C1c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B11 compound treatment 1.164992E7 887000.0 0.5 1.288664E7 1670000.0 0.94 1.324968E7 1408427.0967742 0.826992983158845 1.3091 0.9703 1335526 TimTec1_004257 CCOC(=O)c1nnn(c1CN2CCSCC2)c3nonc3N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B12 compound treatment 1.107944E7 316000.0 0.18 1.249028E7 1280000.0 0.72 1.227144E7 430187.0967742 0.252595048258131 0.6636 0.8478 1291333 TimTec1_004258 CC1(C)NN(C(=S)N1)c2nc3ccccc3s2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B13 compound treatment 1.242588E7 1660000.0 0.93 1.273112E7 1520000.0 0.85 1.314632E7 1305067.0967742 0.766302589644638 1.4751 0.9968 1385793 TimTec1_004259 Cc1nn(c(O)c1C2CC(=O)N(C2=O)c3ccccc3)c4cccc(Cl)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B14 compound treatment 1.173944E7 976000.0 0.55 1.165032E7 438000.0 0.25 1.309276E7 1251507.0967742 0.734853504151014 0.8831 0.9302 1213104 TimTec1_004260 CC(CC(=O)C1C(C)C=CCC1(C)C)Nc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B15 compound treatment 1.234996E7 1590000.0 0.89 1.243176E7 1220000.0 0.69 1.319236E7 1351107.0967742 0.793336120192181 1.3688 0.9944 3212233 TimTec1_004261 CN/C(=N\C)/SC1CC(=O)N(C1=O)c2ccccc2F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B16 compound treatment 1.114352E7 380000.0 0.21 1.190608E7 694000.0 0.39 1.200864E7 167387.0967742 0.0982854950892689 0.4055 0.8897 1345990 TimTec1_004262 CCC(=O)Nc1ccccc1C(=O)OCC(=O)Nc2nc3ccc(cc3s2)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B17 compound treatment 1.15528E7 789000.0 0.44 1.297244E7 1760000.0 0.99 1.303184E7 1190587.0967742 0.699082811688887 1.2316 0.954 1326177 TimTec1_004263 COc1cccc2c(CCN)c[nH]c12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B18 compound treatment 299360.0 -1.05E7 -5.88 247880.0 -1.1E7 -6.17 418200.0 -1.14230529032258E7 -6.707329487523 -10.8292 -0.9985 3085165 TimTec1_004264 CCC1=C(C)/C(=C\c2[nH]c(C)c(CC)c2C)/N=C1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B19 compound treatment 8045000.0 -2720000.0 -1.53 8276200.0 -2940000.0 -1.65 9643400.0 -2197852.9032258 -1.29052397042488 -2.5809 -0.995 3212234 TimTec1_004265 CCOc1cc(/C=C/2\OC(=O)c3c2cc(C)[nH]c3=S)ccc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B20 compound treatment 1.075224E7 -11100.0 -0.01 1.095812E7 -254000.0 -0.14 1.169224E7 -149012.9032258 -0.0874966305676106 -0.1368 -0.8145 1379087 TimTec1_004266 Cc1ccc(OCc2nn(CN3CCC4(CC3)OCCO4)c(=S)n2C)cc1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B21 compound treatment 1.128164E7 518000.0 0.29 1.218668E7 974000.0 0.55 1.250252E7 661267.0967742 0.388279414872517 0.7089 0.968 1413553 TimTec1_004267 CCC(Sc1nnc(C)c(=O)[nH]1)C(=O)Nc2ccccc2C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B22 compound treatment 1.13044E7 541000.0 0.3 1.221748E7 1010000.0 0.57 1.21908E7 349547.0967742 0.20524526755974 0.6206 0.9205 3212308 TimTec1_004268 COc1ccc(Br)cc1S(=O)(=O)NCCCN2CCOCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B23 mock treatment 1.097348E7 210000.0 0.12 1.181104E7 599000.0 0.34 1.200376E7 162507.0967742 0.0954200817731956 0.3178 0.8599 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 B24 mock treatment 1.022224E7 -541000.0 -0.3 1.03612E7 -851000.0 -0.48 1.034384E7 -1497412.9032258 -0.879243211590798 -0.9598 -0.9172 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C01 compound treatment 1.028132E7 -482000.0 -0.27 1.158264E7 370000.0 0.21 1.162328E7 -217972.9032258 -0.127988208902941 -0.1099 -0.3012 1539639 TimTec1_004269 COc1ccc(cc1)C(N)CC(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C02 compound treatment 9435440.0 -1330000.0 -0.75 9707240.0 -1510000.0 -0.85 9867120.0 -1974132.9032258 -1.159161210779 -1.589 -0.9821 1192605 TimTec1_004270 O=C(NCCc1ccccc1)c2ccc(o2)C(=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C03 compound treatment 1.054028E7 -223000.0 -0.13 1.136644E7 154000.0 0.09 1.19E7 58747.0967742 0.0344948183150483 -0.0024 -0.0152 3085169 TimTec1_004271 NC/1=C(C#N)C(=N)S\C1=C\c2ccc(Cl)c(Cl)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C04 compound treatment 1.03946E7 -369000.0 -0.21 1.153156E7 319000.0 0.18 1.183204E7 -9212.90322580002 -0.00540958516043063 -0.019 -0.0692 3212309 TimTec1_004272 CCCCC(CC)CNC1=NS(=O)(=O)c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C05 compound treatment 1.179976E7 1040000.0 0.58 1.206708E7 855000.0 0.48 1.339012E7 1548867.0967742 0.909455820476329 1.1389 0.9635 1436367 TimTec1_004273 CSc1nc2nc(N)nc(N)c2s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C06 compound treatment 1.198344E7 1220000.0 0.69 1.338384E7 2170000.0 1.22 1.302184E7 1180587.0967742 0.693211063090376 1.5016 0.9605 3212310 TimTec1_004274 COc1ccc(Cc2nnc(S)s2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C07 compound treatment 1.109976E7 336000.0 0.19 1.268288E7 1470000.0 0.83 1.259624E7 754987.0967742 0.443309442737759 0.8429 0.8801 3085173 TimTec1_004275 OC(=O)CSC1=CC(=O)N(C1=O)c2cccc(Cl)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C08 compound treatment 1.221276E7 1450000.0 0.81 1.280944E7 1600000.0 0.9 1.365176E7 1810507.0967742 1.06308425080776 1.6028 0.9938 1438726 TimTec1_004276 Cc1ccnc(c1)N2C(=O)OC(C)(C)C2(C)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C09 compound treatment 1.188888E7 1130000.0 0.63 1.269292E7 1480000.0 0.83 1.341444E7 1573187.0967742 0.923735913067907 1.3795 0.9885 1517107 TimTec1_004277 CC(=O)N1CCN2C(=O)C1CCCC(=O)c3cc(ccc23)C4CCCCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C10 compound treatment 1.182124E7 1060000.0 0.59 1.279204E7 1580000.0 0.89 1.330024E7 1458987.0967742 0.856680544072915 1.351 0.986 1430711 TimTec1_004278 COC(=O)c1cccc(NC(=O)COC(=O)c2cc3ccccc3o2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C11 compound treatment 1.207368E7 1310000.0 0.74 1.276664E7 1550000.0 0.87 1.312892E7 1287667.0967742 0.756085747083229 1.3666 0.997 1141099 TimTec1_004279 OC(=O)CCS(=O)(=O)c1ccc2ccccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C12 compound treatment 1.335148E7 2590000.0 1.45 1.308844E7 1880000.0 1.06 1.388692E7 2045667.0967742 1.20116429085034 2.1425 0.9913 3085175 TimTec1_004280 Cc1cccc(c1)n2nn[nH]c2=S 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C13 compound treatment 1.104136E7 278000.0 0.16 1.293372E7 1720000.0 0.97 1.226728E7 426027.0967742 0.25015240084115 0.794 0.784 3212311 TimTec1_004281 Brc1ccc(/C=C/2\C(=O)NN(C2=O)c3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C14 compound treatment 1.21476E7 1380000.0 0.78 1.260864E7 1400000.0 0.79 1.383472E7 1993467.0967742 1.17051376316612 1.5785 0.9804 1600116 TimTec1_004282 NS(=O)(=O)c1ncn(Cc2ccccc2)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C15 compound treatment 1.052004E7 -243000.0 -0.14 1.105564E7 -157000.0 -0.09 1.210128E7 260027.0967742 0.152681374105872 -0.0417 -0.1869 1916017 TimTec1_004283 Nc1ccc(cc1)c2cnc(nc2)c3ccc(N)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C16 compound treatment 9955040.0 -808000.0 -0.45 1.202556E7 813000.0 0.46 1.281664E7 975387.0967742 0.572722781848936 0.3328 0.3859 1129774 TimTec1_004284 CCOC(=O)c1oc2ccccc2c1NC(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C17 compound treatment 1.03438E7 -420000.0 -0.24 9652040.0 -1560000.0 -0.88 1.035228E7 -1488972.9032258 -0.874287455773654 -1.1479 -0.91 1248984 TimTec1_004285 COc1ccc(NC(=O)c2ccc3ccccc3c2OC)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C18 compound treatment 1.205144E7 1290000.0 0.72 1.229892E7 1090000.0 0.61 1.302608E7 1184827.0967742 0.695700684496145 1.1725 0.9975 3085247 TimTec1_004286 CC(NC(=O)Nc1ccccc1Br)(C(F)(F)F)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C19 compound treatment 1.1692E7 929000.0 0.52 1.262328E7 1410000.0 0.79 1.313924E7 1297987.0967742 0.762145391636892 1.1997 0.9849 1510374 TimTec1_004287 COc1ccc(NC(=O)C2CCC(=O)N2C(=O)OCc3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C20 compound treatment 1.147436E7 711000.0 0.4 1.258916E7 1380000.0 0.77 1.32976E7 1456347.0967742 0.855130402442908 1.1717 0.9595 3085249 TimTec1_004288 CC1(C)Cc2ccccc2C(=N1)N3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C21 compound treatment 1.142128E7 658000.0 0.37 1.175124E7 539000.0 0.3 1.265344E7 812187.0967742 0.476895844721241 0.6638 0.983 1404871 TimTec1_004289 O=C(N1CCSC1c2ccccc2)c3cc4ccccc4oc3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C22 compound treatment 1.13478E7 584000.0 0.33 1.201804E7 806000.0 0.45 1.273936E7 898107.0967742 0.527345908679645 0.7558 0.9827 1143185 TimTec1_004290 CC(C)(C)C(=O)N1CCCC1C(=O)Nc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C23 mock treatment 1.106964E7 306000.0 0.17 1.165012E7 438000.0 0.25 1.232848E7 487227.0967742 0.286087502264036 0.4067 0.9803 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 C24 mock treatment 1.050936E7 -254000.0 -0.14 1.064328E7 -569000.0 -0.32 1.0901E7 -940252.9032258 -0.552092866676174 -0.5861 -0.8961 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D01 compound treatment 1.1249E7 486000.0 0.27 1.176652E7 554000.0 0.31 1.192156E7 80307.0967742 0.0471543082934374 0.3648 0.8747 3212312 TimTec1_004291 CCC(SC1=NC(=O)C(C(=O)N1)c2ccccc2)C(=O)Nc3sc4CCCCc4c3C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D02 compound treatment 1.133096E7 568000.0 0.32 1.254628E7 1330000.0 0.75 1.232316E7 481907.0967742 0.282963732009628 0.7809 0.9045 1681507 TimTec1_004292 S=C(SCc1ccc(CSC(=S)N2CCOCC2)cc1)N3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D03 compound treatment 1.173408E7 971000.0 0.55 1.24248E7 1210000.0 0.68 1.300172E7 1160467.0967742 0.681397104910172 1.1022 0.9949 1369855 TimTec1_004293 CCC(=O)N1CCC(CC1)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D04 compound treatment 1.216376E7 1400000.0 0.79 1.242436E7 1210000.0 0.68 1.22494E7 408147.0967742 0.239653714347013 0.9864 0.9232 1327254 TimTec1_004294 O=C1C(C(=O)c2ccccc12)C3=Nc4ccccc4NC(C3)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D05 compound treatment 1.186876E7 1110000.0 0.62 1.200508E7 793000.0 0.45 1.270172E7 860467.0967742 0.505244646954851 0.9078 0.9905 1670837 TimTec1_004295 OC(C#CCN1CCCC1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D06 compound treatment 1.12804E7 517000.0 0.29 1.250748E7 1300000.0 0.73 1.201336E7 172107.0967742 0.101056960427766 0.6469 0.8176 3085254 TimTec1_004296 Nc1ccc2nc(SCC(=O)c3ccc(F)cc3)sc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D07 compound treatment 1.15402E7 777000.0 0.44 1.304008E7 1830000.0 1.03 1.318852E7 1347267.0967742 0.791081368730353 1.3026 0.9514 1149209 TimTec1_004297 Cn1ccnc1SCC(=O)Nc2ccccc2Oc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D08 compound treatment 6288560.0 -4470000.0 -2.51 6818640.0 -4390000.0 -2.47 7363960.0 -4477292.9032258 -2.62895383296381 -4.3969 -0.9997 1583796 TimTec1_004298 OC(=O)c1ccc(cc1)c2cnc3ccccc3n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D09 compound treatment 1.219816E7 1430000.0 0.81 1.238452E7 1170000.0 0.66 1.240732E7 566067.0967742 0.332380368214695 1.0381 0.9495 1479857 TimTec1_004299 Nc1ccc(OCC(=O)N2CCOCC2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D10 compound treatment 1.145928E7 696000.0 0.39 1.175216E7 540000.0 0.3 1.217044E7 329187.0967742 0.193290387413172 0.5127 0.9646 1457410 TimTec1_004300 C(Nc1ccc2oc(nc2c1)c3ccccc3)c4cccnc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D11 compound treatment 3231320.0 -7530000.0 -4.23 327560.0 -1.09E7 -6.13 1871600.0 -9969652.9032258 -5.85392954621545 -9.3598 -0.9882 3085258 TimTec1_004301 CC(=O)OC1(CN2CCC1CC2)C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D12 compound treatment 1.276308E7 2000000.0 1.12 1.205332E7 841000.0 0.47 1.418028E7 2339027.0967742 1.37341790773625 1.7147 0.9338 1325596 TimTec1_004302 CC(=O)N1C(O)C(O)N(C(=O)C)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D13 compound treatment 1.218424E7 1420000.0 0.8 1.2976E7 1760000.0 0.99 1.558628E7 3745027.0967742 2.19898576068686 2.3035 0.9064 3085259 TimTec1_004303 CNC(=N)NC(=O)Nc1c(C)cccc1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D14 compound treatment 1.227412E7 1510000.0 0.85 1.290672E7 1690000.0 0.95 1.382756E7 1986307.0967742 1.16630959116958 1.7139 0.9912 1635468 TimTec1_004304 COc1ccc2n(c(C)c(C(=O)N3CCN(C)CC3)c2c1)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D15 compound treatment 1.227872E7 1520000.0 0.85 1.289832E7 1690000.0 0.95 1.354536E7 1704107.0967742 1.00060884571961 1.617 0.9978 1665310 TimTec1_004305 CC1(C)CC(=O)CC(=C1)NCC2CCCO2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D16 compound treatment 1.166752E7 904000.0 0.51 1.249928E7 1290000.0 0.72 1.29336E7 1092347.0967742 0.641398753457117 1.0817 0.99 1262068 TimTec1_004306 Cc1cc(=O)oc2c3c(OC(=O)c4ccccc4)coc3c(NC(=O)c5ccccc5)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D17 compound treatment 1.221244E7 1450000.0 0.81 1.243708E7 1220000.0 0.69 1.330336E7 1462107.0967742 0.85851252963565 1.3636 0.9959 1639736 TimTec1_004307 CC(C)OC(=O)C1C(C2CC1C=C2)C(=O)NCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D18 compound treatment 1.216224E7 1400000.0 0.79 1.11804E7 -32100.0 -0.02 1.324928E7 1408027.0967742 0.826758113214904 0.9206 0.807 3212313 TimTec1_004308 O=C(CSc1nnc[nH]1)C2CC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D19 compound treatment 1.20196E7 1260000.0 0.71 1.248364E7 1270000.0 0.72 1.331928E7 1478027.0967742 0.867860353404479 1.3216 0.9953 1018938 TimTec1_004309 O=C(N1CCN(CC1)C(=O)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D20 compound treatment 1.202128E7 1260000.0 0.71 1.118988E7 -22600.0 -0.01 1.267388E7 832627.0967742 0.488897698856597 0.6829 0.7947 1028190 TimTec1_004310 COc1ccc(CC(O)CN2CCOCC2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D21 compound treatment 1.193484E7 1170000.0 0.66 1.20578E7 845000.0 0.48 1.226056E7 419307.0967742 0.246206585782951 0.7968 0.939 1610412 TimTec1_004311 CC(C)(C)OC(=O)N1CC(O)CC1C(=O)N2CCOCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D22 compound treatment 1.127072E7 507000.0 0.28 1.19166E7 704000.0 0.4 1.209596E7 254707.0967742 0.149557603851465 0.4797 0.9396 1636298 TimTec1_004312 Cn1ccnc1SCC(=O)N2c3ccccc3CCc4ccccc24 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D23 mock treatment 1.152504E7 762000.0 0.43 1.138304E7 171000.0 0.1 1.223812E7 396867.0967742 0.233030381927893 0.437 0.88 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 D24 mock treatment 1.108532E7 322000.0 0.18 1.136864E7 156000.0 0.09 1.168736E7 -153892.9032258 -0.0903620438836839 0.103 0.4672 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E01 compound treatment 1.088764E7 124000.0 0.07 1.140608E7 194000.0 0.11 1.143416E7 -407092.9032258 -0.239034718397976 -0.0348 -0.1279 3212314 TimTec1_004313 CC(=O)NCC(c1ccccc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E02 compound treatment 1.127336E7 510000.0 0.29 1.26182E7 1410000.0 0.79 1.231332E7 472067.0967742 0.277185931388694 0.7823 0.8829 1202468 TimTec1_004314 O=C(NCN1CCN(Cc2ccccc2)CC1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E03 compound treatment 8351920.0 -2410000.0 -1.35 9045800.0 -2170000.0 -1.22 9525920.0 -2315332.9032258 -1.35950527296019 -2.2711 -0.9988 3085337 TimTec1_004315 COc1ccc(/N=C/c2ccc(Sc3ccccn3)o2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E04 compound treatment 1.146296E7 700000.0 0.39 1.162904E7 417000.0 0.23 1.223248E7 391227.0967742 0.229718715718333 0.4949 0.9665 1420647 TimTec1_004316 O=C(COC(=O)c1ccco1)N2c3ccccc3Sc4ccccc24 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E05 compound treatment 1.132692E7 564000.0 0.32 1.209764E7 885000.0 0.5 1.25284E7 687147.0967742 0.403475500245463 0.7034 0.9837 1547103 TimTec1_004317 CC(N1C(=O)CCC1=O)C(=O)Oc2ccc3c(C)cc(=O)oc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E06 compound treatment 1.311248E7 2350000.0 1.32 1.329296E7 2080000.0 1.17 1.34626E7 1621347.0967742 0.952014254318335 1.9876 0.9915 1714581 TimTec1_004318 Cc1ccc(CCP(=O)(O)CN2CCCCC2)cn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E07 compound treatment 1.028696E7 -476000.0 -0.27 1.186936E7 657000.0 0.37 1.205148E7 210227.0967742 0.123440066085289 0.1303 0.2755 3085340 TimTec1_004319 Cc1ccc(NC(=O)CC2CCC2)cc1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E08 compound treatment 1.253256E7 1770000.0 0.99 1.239732E7 1180000.0 0.67 1.317604E7 1334787.0967742 0.783753426479411 1.4113 0.9865 3212315 TimTec1_004320 Cc1cc(C)nc(n1)N2C(=C)C(C)(C)OC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E09 compound treatment 1.20006E7 1240000.0 0.69 1.315564E7 1940000.0 1.09 1.322688E7 1385627.0967742 0.81360539635424 1.5025 0.9819 3085343 TimTec1_004321 Cc1sc(/N=C/c2ccc(Cl)c(Cl)c2)c(C#N)c1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E10 compound treatment 1.085348E7 90200.0 0.05 9228720.0 -1980000.0 -1.12 1.075556E7 -1085692.9032258 -0.637491578292914 -0.9835 -0.7643 1671390 TimTec1_004322 Ic1ccc(Nc2nc3nonc3n4nnnc24)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E11 compound treatment 1.265648E7 1890000.0 1.06 1.286704E7 1650000.0 0.93 1.31204E7 1279147.0967742 0.751083017277298 1.5853 0.9904 1687107 TimTec1_004323 CN1CCC(O)(CC1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E12 compound treatment 1.351712E7 2750000.0 1.55 1.214556E7 933000.0 0.53 1.344304E7 1601787.0967742 0.940529114059648 1.7393 0.9227 1215551 TimTec1_004324 COC(=O)C1=C(N)N(C2=C(C1c3ccc(OC)cc3)C(=O)CCC2)c4ccc(cc4)S(=O)(=O)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E13 compound treatment 1.223244E7 1470000.0 0.83 1.459052E7 3380000.0 1.9 1.358808E7 1746827.0967742 1.02569295573245 2.1665 0.9367 1516816 TimTec1_004325 Clc1cccc(OCCN2CCN(CC2)c3ccccc3)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E14 compound treatment 1.215928E7 1400000.0 0.78 1.24536E7 1240000.0 0.7 1.325484E7 1413587.0967742 0.830022805435676 1.3353 0.9975 3212316 TimTec1_004326 O=C(CCCc1ccccc1)NC2CC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E15 compound treatment 1.198764E7 1220000.0 0.69 1.294184E7 1730000.0 0.97 1.383448E7 1993227.0967742 1.17037284119975 1.6348 0.9787 1919871 TimTec1_004327 CCS(=O)(=O)C(=C1Nc2ccccc2N1)S(=O)(=O)CC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E16 compound treatment 1.186592E7 1100000.0 0.62 1.197704E7 765000.0 0.43 1.211312E7 271867.0967742 0.159633524446509 0.6982 0.9057 1212477 TimTec1_004328 CCOC(=O)C1=C(C)OC(=C(C#N)C21C(=O)Nc3ccc(C)cc32)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E17 compound treatment 1.160472E7 841000.0 0.47 1.26144E7 1400000.0 0.79 1.42714E7 2430147.0967742 1.42692128096588 1.5523 0.9144 3212317 TimTec1_004329 Nc1ccnc(c1C(=O)c2ccccc2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E18 compound treatment 1.11084E7 345000.0 0.19 8456400.0 -2760000.0 -1.55 1.124696E7 -594292.9032258 -0.348953852162096 -0.9853 -0.615 1147665 TimTec1_004330 Fc1ccccc1C(=O)Nc2ccc3nc(SCC(=O)NC4CC4)sc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E19 compound treatment 1.175908E7 996000.0 0.56 1.109024E7 -122000.0 -0.07 1.358368E7 1742427.0967742 1.0231093863491 0.8739 0.7482 1323101 TimTec1_004331 COC(=O)c1c(CC=C(C)C)c(C)nc2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E20 compound treatment 1.19658E7 1200000.0 0.68 1.194584E7 733000.0 0.41 1.284792E7 1006667.0967742 0.591089611465077 0.9696 0.9814 3212392 TimTec1_004332 CC1CN=C(S1)N(Cc2ccccc2Cl)C(=O)Nc3cccc(Cl)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E21 compound treatment 1.150616E7 743000.0 0.42 1.214036E7 928000.0 0.52 1.350236E7 1661107.0967742 0.975360326746014 1.1056 0.935 3085349 TimTec1_004333 S=c1[nH]nc(Cc2ccccc2)[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E22 compound treatment 1.123616E7 473000.0 0.27 1.122464E7 12200.0 0.01 1.222692E7 385667.0967742 0.226454023497561 0.288 0.8251 1488335 TimTec1_004334 O=C(CSc1ncnc2[nH]cnc12)c3ccc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E23 mock treatment 1.161928E7 856000.0 0.48 1.19574E7 745000.0 0.42 1.232632E7 485067.0967742 0.284819204566758 0.6841 0.9792 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 E24 mock treatment 1.095684E7 194000.0 0.11 1.110868E7 -104000.0 -0.06 1.126292E7 -578332.9032258 -0.339582541398873 -0.167 -0.4623 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F01 compound treatment 7433120.0 -3330000.0 -1.87 8205400.0 -3010000.0 -1.69 8050120.0 -3791132.9032258 -2.2260579311284 -3.3424 -0.9935 3085351 TimTec1_004335 Cc1ccnc(NC(=O)c2cccs2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F02 compound treatment 1.17462E7 983000.0 0.55 1.268212E7 1470000.0 0.83 1.236596E7 524707.0967742 0.308094816011254 0.9742 0.9357 3085353 TimTec1_004336 CSc1ncc(F)c(n1)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F03 compound treatment 9894480.0 -869000.0 -0.49 1.102028E7 -192000.0 -0.11 1.0588E7 -1253252.9032258 -0.73587859780956 -0.7691 -0.8645 3212393 TimTec1_004337 CCC(Sc1ccccn1)C(=O)Nc2cccc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F04 compound treatment 1.144972E7 686000.0 0.39 1.202216E7 810000.0 0.46 1.244116E7 599907.0967742 0.352250365472055 0.6891 0.9942 3084406 TimTec1_004338 Nc1ccc(OCCOc2ccc(N)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F05 compound treatment 1.143976E7 676000.0 0.38 1.261088E7 1400000.0 0.79 1.344048E7 1599227.0967742 0.939025946418429 1.216 0.9479 1262298 TimTec1_004339 Fc1ccc(CNC(=O)C2CN(C(=O)C2)c3ccc(F)cc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F06 compound treatment 1.197692E7 1210000.0 0.68 1.296508E7 1750000.0 0.99 1.20754E7 234147.0967742 0.137485288732927 1.0425 0.8637 3212394 TimTec1_004340 CN(CC(COc1ccccc1)OC(=O)c2ccc(Cl)cc2)C3=NS(=O)(=O)c4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F07 compound treatment 1.1985E7 1220000.0 0.69 1.18072E7 595000.0 0.33 1.270532E7 864067.0967742 0.507358476450314 0.8824 0.9626 1118159 TimTec1_004341 Cc1ccc(OCCN)c(Br)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F08 compound treatment 1.207524E7 1310000.0 0.74 1.313744E7 1920000.0 1.08 1.269296E7 851707.0967742 0.500100995182555 1.3398 0.9552 1694465 TimTec1_004342 COc1ccc(cc1)c2nn(CO)c(=S)n2c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F09 compound treatment 1.220992E7 1450000.0 0.81 1.280956E7 1600000.0 0.9 1.3177E7 1335747.0967742 0.784317114344869 1.441 0.9983 3084411 TimTec1_004343 O=S1(=O)N=C(N2CCNCC2)c3ccccc31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F10 compound treatment 1.210512E7 1340000.0 0.75 1.258588E7 1370000.0 0.77 1.372076E7 1879507.0967742 1.10359931613749 1.5186 0.9836 1406499 TimTec1_004344 Cc1cc(C)c(COC(=O)c2nonc2N)c(C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F11 compound treatment 1.229852E7 1540000.0 0.86 1.346148E7 2250000.0 1.27 1.361884E7 1777587.0967742 1.04375445442147 1.8314 0.988 1497656 TimTec1_004345 CC1(C)CC(=O)C(C(O)c2ccccc2)C(C)(C)N1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F12 compound treatment 1.324784E7 2480000.0 1.4 1.3164E7 1950000.0 1.1 1.384668E7 2005427.0967742 1.17753637448994 2.1198 0.9948 3084413 TimTec1_004346 O=C(CSc1nnc(o1)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F13 compound treatment 1.268056E7 1920000.0 1.08 1.23206E7 1110000.0 0.62 1.374796E7 1906707.0967742 1.11957047232544 1.6283 0.9727 1560213 TimTec1_004347 Clc1cccc(NC(=O)NC2CCN(C2)C3CCCCC3)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F14 compound treatment 1.210516E7 1340000.0 0.75 1.235184E7 1140000.0 0.64 1.387316E7 2031907.0967742 1.19308476477879 1.4943 0.964 3084415 TimTec1_004348 Cc1cn(C(=O)c2ccc(Cl)cc2Cl)c(C)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F15 compound treatment 1.176308E7 1000000.0 0.56 1.144628E7 234000.0 0.13 1.362496E7 1783707.0967742 1.04734796456376 1.0049 0.8404 1406332 TimTec1_004349 O=C(CSc1nc2ccc(NC(=O)C3CCCCC3)cc2s1)NCC4CCCO4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F16 compound treatment 1.20896E7 1330000.0 0.74 1.152532E7 313000.0 0.18 1.33498E7 1508547.0967742 0.885780930127134 1.0432 0.8911 3212395 TimTec1_004350 O=C1C2C(C3=C(CCCC3=O)N=C2c4ccccc14)c5cccs5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F17 compound treatment 1.18546E7 1090000.0 0.61 1.161364E7 401000.0 0.23 1.137076E7 -470492.9032258 -0.276261604512534 0.3248 0.4579 1570773 TimTec1_004351 CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)N2CCNCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F18 compound treatment 1.181964E7 1060000.0 0.59 1.227452E7 1060000.0 0.6 1.315496E7 1313707.0967742 0.771375780433751 1.1331 0.9921 1621338 TimTec1_004352 O=C(CSc1nc2ccccc2[nH]1)C3CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F19 compound treatment 1.202416E7 1260000.0 0.71 1.285332E7 1640000.0 0.92 1.376448E7 1923227.0967742 1.12927060101018 1.5941 0.983 1630047 TimTec1_004353 O=S1(=O)CCC(C1)N2CCOCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F20 compound treatment 1.108092E7 318000.0 0.18 1.205976E7 847000.0 0.48 1.295844E7 1117187.0967742 0.655984176975818 0.7571 0.9117 1536902 TimTec1_004354 Cc1ccc(cc1)C(=O)C2C(=O)OC(=CC2=O)c3ccc(C)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F21 compound treatment 1.169692E7 934000.0 0.52 1.229928E7 1090000.0 0.61 1.30674E7 1226147.0967742 0.719962749705191 1.0716 0.9917 1248516 TimTec1_004355 Nc1nnc(SCC(=O)N2CCCCC2)s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F22 compound treatment 1.106268E7 299000.0 0.17 1.142708E7 215000.0 0.12 1.232836E7 487107.0967742 0.286017041280854 0.332 0.9402 3084420 TimTec1_004356 O=c1/c(=C\c2ccncc2)/sc3nc4ccccc4n13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F23 mock treatment 9810600.0 -953000.0 -0.54 1.008304E7 -1130000.0 -0.64 1.155868E7 -282572.9032258 -0.16591970484932 -0.7718 -0.9108 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 F24 mock treatment 1.074672E7 -16600.0 -0.01 1.167368E7 461000.0 0.26 1.188484E7 43587.0967742 0.025593247439706 0.1593 0.6102 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G01 compound treatment 1.112796E7 365000.0 0.2 1.219896E7 986000.0 0.56 1.197068E7 129427.0967742 0.0759963374093221 0.4827 0.809 1052156 TimTec1_004357 O=S(=O)(Nc1ccccn1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G02 compound treatment 1.05288E7 -235000.0 -0.13 1.169748E7 485000.0 0.27 1.181972E7 -21532.9032258 -0.0126435794337958 0.0743 0.2448 1455699 TimTec1_004358 CC1(C)CC(CC(C)(C)N1)NC(=O)c2ccc(o2)C(=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G03 compound treatment 1.0411E7 -352000.0 -0.2 1.203364E7 821000.0 0.46 1.260172E7 760467.0967742 0.446527160969743 0.4104 0.6103 3084422 TimTec1_004359 CCc1ccc2oc(nc2c1)c3cc(/N=C\c4ccccc4O)ccc3O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G04 compound treatment 9307040.0 -1460000.0 -0.82 9950800.0 -1260000.0 -0.71 1.024588E7 -1595372.9032258 -0.936762860861809 -1.4231 -0.9937 3212396 TimTec1_004360 CSc1nsc(SC)c1NC(=O)Nc2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G05 compound treatment 1.287568E7 2110000.0 1.19 1.274516E7 1530000.0 0.86 1.324444E7 1403187.0967742 0.823916186893225 1.6588 0.9859 3084424 TimTec1_004361 O=C(CCCCN1CCCCC1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G06 compound treatment 1.168496E7 922000.0 0.52 1.239448E7 1180000.0 0.67 1.258976E7 748507.0967742 0.439504549645924 0.9368 0.9853 3212397 TimTec1_004362 FC(F)(F)C(NC(=O)c1ccccc1)(N2CCOCC2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G07 compound treatment 1.287484E7 2110000.0 1.19 1.220764E7 995000.0 0.56 1.159584E7 -245412.9032258 -0.144100287057254 0.925 0.701 1644204 TimTec1_004363 CC(C)Nc1nc(Cl)nc(NC(C)(C)CO)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G08 compound treatment 1.257756E7 1810000.0 1.02 1.276128E7 1550000.0 0.87 1.04522E7 -1389052.9032258 -0.815616943777335 0.6208 0.3955 1320611 TimTec1_004364 O=C(Nc1ccccn1)c2cccc(c2)N3C(=O)CCC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G09 compound treatment 1.168872E7 925000.0 0.52 1.201976E7 807000.0 0.45 1.290864E7 1067387.0967742 0.626742868955235 0.9243 0.9913 1019380 TimTec1_004365 C(N1CCCCC1)c2c[nH]c3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G10 compound treatment 1.24866E7 1720000.0 0.97 1.353172E7 2320000.0 1.31 1.34902E7 1648947.0967742 0.968220280450225 1.8716 0.9893 1557179 TimTec1_004366 OC(=O)CCn1c2ccccc2c3ccccc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G11 compound treatment 1.22684E7 1510000.0 0.85 1.230472E7 1090000.0 0.61 1.420416E7 2362907.0967742 1.3874396433895 1.6441 0.9464 1693338 TimTec1_004367 COc1ccc(cc1)c2ncccc2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G12 compound treatment 1.36896E7 2930000.0 1.64 1.26272E7 1410000.0 0.8 1.359404E7 1752787.0967742 1.02919251789716 2.0029 0.9554 1612647 TimTec1_004368 NNC(=O)c1ccc(OCC(O)CO)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G13 compound treatment 1.24668E7 1700000.0 0.96 1.317608E7 1960000.0 1.11 1.419676E7 2355507.0967742 1.3830945494266 1.9891 0.9884 1723169 TimTec1_004369 CCN(CC)c1ccc(Nc2cc(C)c(C#N)c3nc4ccccc4n23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G14 compound treatment 1.215076E7 1390000.0 0.78 1.327456E7 2060000.0 1.16 1.370876E7 1867507.0967742 1.09655321781928 1.7532 0.9867 3084439 TimTec1_004370 N/C(=N\O)/c1cccc(n1)\C(=N\O)\N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G15 compound treatment 1.234208E7 1580000.0 0.89 1.21492E7 937000.0 0.53 1.351036E7 1669107.0967742 0.980057725624822 1.3822 0.9714 3212398 TimTec1_004371 Cn1c2N(CC(=O)c2c(=O)n(C)c1=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G16 compound treatment 1.231084E7 1550000.0 0.87 1.278364E7 1570000.0 0.88 1.33528E7 1511547.0967742 0.887542454706687 1.5249 1.0 3084441 TimTec1_004372 C(Sc1nnc(SCc2ccccn2)s1)c3ccccn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G17 compound treatment 1.200628E7 1240000.0 0.7 1.223636E7 1020000.0 0.58 1.186824E7 26987.0967742 0.0158461447661782 0.745 0.8228 3212399 TimTec1_004373 Fc1ccc(cc1)c2cc(nc(SCC(=O)Oc3ccccc3)c2C#N)c4ccco4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G18 compound treatment 1.260816E7 1840000.0 1.04 1.259284E7 1380000.0 0.78 1.364592E7 1804667.0967742 1.05965514962623 1.6587 0.9912 1717375 TimTec1_004374 O=C(CCSc1nccn1Cc2ccccc2)NC3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G19 compound treatment 1.179596E7 1030000.0 0.58 1.191892E7 706000.0 0.4 1.318616E7 1344907.0967742 0.789695636061104 1.0204 0.965 3084443 TimTec1_004375 Cc1cc(C)nc(SCC(=O)c2c(N)no[n+]2[O-])n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G20 compound treatment 1.151688E7 754000.0 0.42 1.181104E7 599000.0 0.34 1.275272E7 911467.0967742 0.535190564807255 0.7479 0.9828 3212400 TimTec1_004376 CC1CN=C(S1)N(C(=O)Nc2ccc(Cl)cc2)c3cccc(C)n3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G21 compound treatment 1.197148E7 1210000.0 0.68 1.224376E7 1030000.0 0.58 1.332956E7 1488307.0967742 0.873896510963748 1.2315 0.9856 3084445 TimTec1_004377 CC(C)C(=O)NC1=NC2C(N=CN2C3CC(O)C(CO)O3)C(=N1)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G22 compound treatment 1.151544E7 752000.0 0.42 1.240532E7 1190000.0 0.67 1.27984E7 957147.0967742 0.562012712405252 0.9561 0.9834 3212401 TimTec1_004378 O=C1CN(C=NN1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G23 mock treatment 1.07326E7 -30700.0 -0.02 1.20978E7 885000.0 0.5 1.257548E7 734227.0967742 0.431119692647251 0.5267 0.799 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 G24 mock treatment 1.058616E7 -177000.0 -0.1 1.183228E7 620000.0 0.35 1.24984E7 657147.0967742 0.38586025444993 0.3668 0.6925 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H01 compound treatment 1.0687E7 -76300.0 -0.04 1.171096E7 498000.0 0.28 1.14714E7 -369852.9032258 -0.217168326617122 0.0119 0.0332 1333222 TimTec1_004379 COc1ccccc1NCn2c(=O)sc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H02 compound treatment 1.173396E7 971000.0 0.55 1.30966E7 1880000.0 1.06 1.284368E7 1002427.0967742 0.588599990059309 1.2669 0.9527 1378323 TimTec1_004380 CSc1ncc(F)c(n1)N(CCO)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H03 compound treatment 1.15286E7 765000.0 0.43 1.257944E7 1370000.0 0.77 1.271176E7 870507.0967742 0.511139882547755 0.9875 0.9692 1426454 TimTec1_004381 O=C(CNC(=O)C(c1ccccc1)c2ccccc2)NC3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H04 compound treatment 1.145512E7 692000.0 0.39 1.219476E7 982000.0 0.55 1.232432E7 483067.0967742 0.283644854847056 0.7073 0.9651 3084448 TimTec1_004382 Cc1ccc(cc1)P(=O)(C)c2ccc(C)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H05 compound treatment 1.172108E7 958000.0 0.54 1.224552E7 1030000.0 0.58 1.256244E7 721187.0967742 0.423462932474793 0.8908 0.9917 1325975 TimTec1_004383 O=c1n(CCc2ccccn2)nc(c3ccccc3)c4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H06 compound treatment 1.177236E7 1010000.0 0.57 1.274108E7 1530000.0 0.86 1.338212E7 1540867.0967742 0.904758421597521 1.3464 0.9819 1363120 TimTec1_004384 OC(COc1ccccc1)CS(=O)(=O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H07 compound treatment 1.1511E7 748000.0 0.42 1.274424E7 1530000.0 0.86 1.022068E7 -1620572.9032258 -0.951559667330056 0.1909 0.1413 1512838 TimTec1_004385 CSCCC1NC(=S)N(Cc2ccccc2)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H08 compound treatment 1.127844E7 515000.0 0.29 1.268976E7 1480000.0 0.83 1.309816E7 1256907.0967742 0.73802424839421 1.0733 0.9342 1461248 TimTec1_004386 Fc1ccc(cc1)C(=O)Nc2ccc3C(=O)OCc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H09 compound treatment 1.127636E7 513000.0 0.29 1.201748E7 805000.0 0.45 1.348092E7 1639667.0967742 0.962771297750807 0.9839 0.8925 1264638 TimTec1_004387 Oc1ccc2occ(C(=O)c3cccs3)c2c1CN4CCOCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H10 compound treatment 1.200204E7 1240000.0 0.7 1.37994E7 2590000.0 1.46 1.376784E7 1926587.0967742 1.13124350853928 1.8956 0.9618 1248397 TimTec1_004388 CCSc1nc2ccccc2n1CC(=O)N3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H11 compound treatment 1.197372E7 1210000.0 0.68 1.261016E7 1400000.0 0.79 1.34074E7 1566147.0967742 0.919602202054556 1.3777 0.9925 3084452 TimTec1_004389 O=C(OC[C@@H]1CCCN2CCCCC12)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H12 compound treatment 1.161372E7 850000.0 0.48 1.080092E7 -412000.0 -0.23 1.293536E7 1094107.0967742 0.642432181210455 0.5129 0.6155 3212402 TimTec1_004390 CCOC(=O)c1[nH]c(COC(=O)C)cc1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H13 compound treatment 1.18816E7 1120000.0 0.63 1.493292E7 3720000.0 2.09 1.490652E7 3065267.0967742 1.7998477779545 2.6109 0.9219 1294077 TimTec1_004391 COc1ccc(cc1)C(=O)c2coc3ccc(OC)cc3c2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H14 compound treatment 1.231308E7 1550000.0 0.87 1.278056E7 1570000.0 0.88 1.394376E7 2102507.0967742 1.23453930988428 1.725 0.9859 1370478 TimTec1_004392 Fc1cc2c(=O)cc[nH]c2cc1N3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H15 compound treatment 1.243808E7 1670000.0 0.94 1.244012E7 1230000.0 0.69 1.193984E7 98587.0967742 0.057887864731515 0.9755 0.8347 1351428 TimTec1_004393 Cc1ccc(cc1)S(=O)(=O)N2CC(=O)N(O)C2c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H16 compound treatment 1.2293E7 1530000.0 0.86 1.22336E7 1020000.0 0.57 1.323184E7 1390587.0967742 0.816517783659101 1.2993 0.9864 3084456 TimTec1_004394 FC(F)(F)c1ccc2sc(S)nc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H17 compound treatment 1.111612E7 353000.0 0.2 1.162084E7 408000.0 0.23 1.119052E7 -650732.9032258 -0.382094001252091 0.0265 0.0544 1715297 TimTec1_004395 N#CC(CCN1CCNCC1)(c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H18 compound treatment 1.270284E7 1940000.0 1.09 1.1671E7 459000.0 0.26 1.257768E7 736427.0967742 0.432411477338923 1.0276 0.8563 1355787 TimTec1_004396 OCCN(CCO)C(=O)CCc1[nH]c2ccccc2c1Sc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H19 compound treatment 1.175264E7 989000.0 0.56 1.239004E7 1180000.0 0.66 1.3038E7 1196747.0967742 0.702699808825569 1.1092 0.9953 3212474 TimTec1_004397 Clc1ccc(NC(=O)CSC2=NC(=O)C(C(=O)N2)c3ccccc3)nc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H20 compound treatment 1.167136E7 908000.0 0.51 1.242992E7 1220000.0 0.69 1.376508E7 1923827.0967742 1.12962290592609 1.3423 0.9478 3084461 TimTec1_004398 CC1CNc2ccccc2N=C1N3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H21 compound treatment 4889200.0 -5870000.0 -3.3 5169800.0 -6040000.0 -3.4 5317480.0 -6523772.9032258 -3.83059544015184 -6.0803 -0.9979 3212475 TimTec1_004399 S=c1[nH]cnc2n(CN3CCCCC3)cnc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H22 compound treatment 1.10326E7 269000.0 0.15 1.081064E7 -402000.0 -0.23 1.173884E7 -102412.9032258 -0.0601342820985506 -0.078 -0.2798 1451020 TimTec1_004400 OC1=C(C(=O)c2ccccc2)C3(O)N(C1=O)c4ccccc4OC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H23 mock treatment 1.235408E7 1590000.0 0.89 1.215E7 938000.0 0.53 1.272188E7 880627.0967742 0.517082092129448 1.1191 0.9652 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 H24 mock treatment 1.128752E7 524000.0 0.29 1.192124E7 709000.0 0.4 1.200216E7 160907.0967742 0.0944806019974339 0.4549 0.9012 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I01 compound treatment 1.152048E7 757000.0 0.43 1.139512E7 183000.0 0.1 1.141076E7 -430492.9032258 -0.252774610118491 0.159 0.3146 3084463 TimTec1_004401 C/C(=N\N)/c1nnn(c1C)c2nonc2N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I02 compound treatment 1.113876E7 375000.0 0.21 1.22974E7 1080000.0 0.61 1.227208E7 430827.0967742 0.252970840168436 0.6204 0.8941 1525911 TimTec1_004402 OP(=O)(CCc1ccccn1)CN2CCOCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I03 compound treatment 9395120.0 -1370000.0 -0.77 8936560.0 -2280000.0 -1.28 9218720.0 -2622532.9032258 -1.53988538990644 -2.0724 -0.9659 1170438 TimTec1_004403 CCN(CC)S(=O)(=O)c1ccc(cc1)c2csc(Nc3cccc(OC)c3)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I04 compound treatment 1.140956E7 646000.0 0.36 1.285468E7 1640000.0 0.92 1.337796E7 1536707.0967742 0.90231577418054 1.2642 0.9422 1584075 TimTec1_004404 O=C(C1C2C1C(=O)C3OCC2O3)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I05 compound treatment 1.077008E7 6770.0 0.0 1.203648E7 824000.0 0.46 1.266208E7 820827.0967742 0.481969035510354 0.5483 0.8196 1217640 TimTec1_004405 CN(C)Cc1cc2ccccc2[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I06 compound treatment 1.115296E7 390000.0 0.22 1.196556E7 753000.0 0.42 1.24258E7 584547.0967742 0.343231359624742 0.5693 0.9686 1227632 TimTec1_004406 N#CCCn1c(nc2ccccc12)C3CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I07 compound treatment 1.195512E7 1190000.0 0.67 1.254756E7 1340000.0 0.75 1.323124E7 1389987.0967742 0.816165478743191 1.2916 0.9968 1733675 TimTec1_004407 Cc1ccc(cc1C)N2NC(=O)CC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I08 compound treatment 1.174092E7 978000.0 0.55 1.256776E7 1360000.0 0.76 1.191212E7 70867.0967742 0.0416113776164433 0.7815 0.8306 1603161 TimTec1_004408 COC(=O)c1ccc(NC(=O)COC(=O)c2cc3ccccc3o2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I09 compound treatment 1.06332E7 -130000.0 -0.07 1.33922E7 2180000.0 1.23 1.275872E7 917467.0967742 0.538713613966362 0.9772 0.7282 1037174 TimTec1_004409 CCOC(=O)c1cc(C(=O)OCC)c(C)nc1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I10 compound treatment 1.154632E7 783000.0 0.44 1.222812E7 1020000.0 0.57 1.295344E7 1112187.0967742 0.653048302676563 0.961 0.9877 1467402 TimTec1_004410 COc1ccc(NC(=O)CSc2ccc3ccccc3n2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I11 compound treatment 1.05716E7 -192000.0 -0.11 1.155836E7 346000.0 0.19 1.182932E7 -11932.9032258 -0.00700670077922555 0.0462 0.2075 1668645 TimTec1_004411 O=C(Nc1cccc2ccccc12)OC3CCS(=O)(=O)C3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I12 compound treatment 1.38694E7 3110000.0 1.74 1.268736E7 1470000.0 0.83 1.381432E7 1973067.0967742 1.15853539602515 2.1555 0.9568 3212476 TimTec1_004412 Cc1cc2/C(=C\c3ccc(Cl)c(Cl)c3)/OC(=O)c2c(=S)[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I13 compound treatment 1.127732E7 514000.0 0.29 1.251588E7 1300000.0 0.73 1.44432E7 2601947.0967742 1.5277979218883 1.4724 0.8564 1917148 TimTec1_004413 O=c1[nH]c2ccc(/N=C/c3ccc(C#Cc4ccccc4)cc3)cc2o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I14 compound treatment 1.20816E7 1320000.0 0.74 1.261292E7 1400000.0 0.79 1.32826E7 1441347.0967742 0.846322779545142 1.3713 0.9985 1236087 TimTec1_004414 O=C(C1CN2CCC1CC2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I15 compound treatment 1.176664E7 1000000.0 0.56 1.263936E7 1430000.0 0.8 1.31022E7 1260947.0967742 0.740396434828008 1.2166 0.9897 1912326 TimTec1_004415 CCOC(=O)C(C#N)C(=O)c1ccc(N)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I16 compound treatment 1.310252E7 2340000.0 1.31 1.198472E7 772000.0 0.43 1.358184E7 1740587.0967742 1.02202898460698 1.5996 0.9298 1609648 TimTec1_004416 CCCC(OC(=O)C)C#CCN1CCCCC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I17 compound treatment 1.24838E7 1720000.0 0.97 1.218164E7 969000.0 0.55 1.249836E7 657107.0967742 0.385836767455536 1.0957 0.9326 3084472 TimTec1_004417 COC(=O)CSc1nsc(SCC(=O)OC)c1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I18 compound treatment 1.107776E7 314000.0 0.18 1.091684E7 -296000.0 -0.17 1.17784E7 -62852.9032258 -0.0369056446428422 -0.0154 -0.0628 3212477 TimTec1_004418 CCC(Sc1nc(C)cc(C)n1)C(=O)Nc2sc3CCCCc3c2C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I19 compound treatment 1.305344E7 2290000.0 1.29 1.244492E7 1230000.0 0.69 1.288904E7 1047787.0967742 0.615234241702154 1.4984 0.945 1539203 TimTec1_004419 CCC1CCCCN1C(=O)c2cc3ccccc3oc2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I20 compound treatment 1.14862E7 723000.0 0.41 1.212468E7 912000.0 0.51 1.337052E7 1529267.0967742 0.897947193223248 1.0493 0.9443 1728922 TimTec1_004420 Nc1nonc1C(=O)OCC(=O)N2CCOCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I21 compound treatment 1.124472E7 481000.0 0.27 1.113888E7 -73600.0 -0.04 1.233232E7 491067.0967742 0.288342253725864 0.2987 0.7515 1427907 TimTec1_004421 CCOc1ccc(OCC)c(c1)C(=O)C2CCCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I22 compound treatment 1.163132E7 868000.0 0.49 1.198872E7 776000.0 0.44 1.25802E7 738947.0967742 0.433891157985748 0.7843 0.9985 1647970 TimTec1_004422 CCC(OC(=O)C)C#CCN1CCOCC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I23 mock treatment 1.13604E7 597000.0 0.34 1.139164E7 179000.0 0.1 1.32804E7 1439147.0967742 0.84503099485347 0.7397 0.8087 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 I24 mock treatment 1.14988E7 735000.0 0.41 1.151236E7 300000.0 0.17 1.171432E7 -126932.9032258 -0.074531809662099 0.2929 0.6475 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J01 compound treatment 1.091768E7 154000.0 0.09 1.152816E7 316000.0 0.18 1.196228E7 121027.0967742 0.0710640685865731 0.1937 0.9218 3084477 TimTec1_004423 Cn1nnnc1SCC(=O)NC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J02 compound treatment 1.03954E7 -368000.0 -0.21 1.199484E7 782000.0 0.44 1.179732E7 -43932.9032258 -0.0257962962944599 0.1201 0.2465 3084491 TimTec1_004424 Cn1c(=O)nc2n(c3cccc(c3)C(F)(F)F)c4ccccc4cc2c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J03 compound treatment 6769560.0 -3990000.0 -2.24 7334960.0 -3880000.0 -2.18 7309000.0 -4532252.9032258 -2.66122496326123 -4.0918 -0.996 3084494 TimTec1_004425 Oc1ccccc1C(=O)N2N=C(CC2(O)C(F)(F)F)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J04 compound treatment 1.10412E7 278000.0 0.16 1.222836E7 1020000.0 0.57 1.168004E7 -161212.9032258 -0.0946601638577937 0.3656 0.6091 1706033 TimTec1_004426 OC(=O)c1cccc(NC(=O)CC(=O)c2ccccc2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J05 compound treatment 1.111508E7 352000.0 0.2 1.273856E7 1530000.0 0.86 1.309376E7 1252507.0967742 0.735440679010865 1.0347 0.9013 1279425 TimTec1_004427 CCCC(=O)Nc1nnc(Cc2ccc(Cl)cc2)s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J06 compound treatment 1.039396E7 -369000.0 -0.21 1.209268E7 880000.0 0.5 1.224212E7 400867.0967742 0.235379081367297 0.3022 0.5153 1425542 TimTec1_004428 Fc1ccc(NC(=O)C2C3C2C4CCC3C4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J07 compound treatment 1.1551E7 788000.0 0.44 1.222736E7 1010000.0 0.57 1.381624E7 1974987.0967742 1.15966277175607 1.2548 0.9184 1301943 TimTec1_004429 Cc1[nH]c(=S)c(C#N)c(C)c1CC(=O)c2ccc(Br)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J08 compound treatment 1.219988E7 1440000.0 0.81 1.257048E7 1360000.0 0.76 1.302908E7 1187827.0967742 0.697462209075698 1.3099 0.9982 1313319 TimTec1_004430 COc1ccc(NC(=O)CC2SCCNC2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J09 compound treatment 1.181492E7 1050000.0 0.59 1.083084E7 -382000.0 -0.21 1.276088E7 919627.0967742 0.53998191166364 0.5288 0.6381 1169823 TimTec1_004431 CCN(CC)c1nc(Nc2ccccc2OC)nc(Nc3cc(C)ccc3C)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J10 compound treatment 1.202164E7 1260000.0 0.71 1.278364E7 1570000.0 0.88 1.364932E7 1808067.0967742 1.06165154414973 1.5316 0.9868 3084499 TimTec1_004432 Cc1ccc(cc1)n2c(SCC=C)nc3sc4CCCc4c3c2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J11 compound treatment 1.034372E7 -420000.0 -0.24 1.14224E7 210000.0 0.12 1.280148E7 960227.0967742 0.563821210973594 0.2577 0.414 1249197 TimTec1_004433 CCOC(=O)N1CCc2[nH]c3ccccc3c2C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J12 compound treatment 1.186384E7 1100000.0 0.62 1.154216E7 330000.0 0.19 1.338116E7 1539907.0967742 0.904194733732064 0.9861 0.8876 1223335 TimTec1_004434 COc1ccc(Cl)cc1NC(=O)CCN2CCN(CC2)c3ccccc3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J13 compound treatment 1.278436E7 2020000.0 1.14 1.300092E7 1790000.0 1.01 1.42158E7 2374547.0967742 1.39427435875816 2.0416 0.9908 1680037 TimTec1_004435 O=c1cc(Nc2ccc(cc2)N3CCCCC3)[nH]c(=O)[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J14 compound treatment 1.21376E7 1370000.0 0.77 1.27732E7 1560000.0 0.88 1.321356E7 1372307.0967742 0.805784227221024 1.4181 0.9985 1142790 TimTec1_004436 Cc1ccc(cc1C)N(Cc2ccc(cc2)C(=O)N3CCOCC3)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J15 compound treatment 1.110556E7 342000.0 0.19 1.202036E7 808000.0 0.45 1.187828E7 37027.0967742 0.021741380359083 0.3861 0.7812 1406310 TimTec1_004437 CCCNc1nc(NC2CCCCC2)nc(OC(C)C)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J16 compound treatment 1.121856E7 455000.0 0.26 1.219672E7 984000.0 0.55 1.300504E7 1163787.0967742 0.683346525444878 0.862 0.9409 3212719 TimTec1_004438 CCC(=O)NC(Nc1sc2CCCCc2c1C(=O)N)(C(F)(F)F)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J17 compound treatment 1.17696E7 1010000.0 0.57 1.2385E7 1170000.0 0.66 1.464372E7 2802467.0967742 1.64553822478563 1.6574 0.8907 1448396 TimTec1_004439 CC(C)C(NC(=O)C(c1ccccc1)c2ccccc2)C(=O)N3CCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J18 compound treatment 1.153408E7 771000.0 0.43 1.3436E7 2220000.0 1.25 1.288908E7 1047827.0967742 0.615257728696548 1.3278 0.9092 1655510 TimTec1_004440 Cc1ccccc1Nc2nc(Nc3ccccc3C)nc(Sc4nccn4C)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J19 compound treatment 1.193728E7 1170000.0 0.66 1.313184E7 1920000.0 1.08 1.512544E7 3284187.0967742 1.92839209827309 2.1179 0.9181 1576794 TimTec1_004441 CC(=O)N(Cc1ccc(cc1)S(=O)(=O)N)C2CC(=O)N(C2=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J20 compound treatment 1.229728E7 1530000.0 0.86 1.288668E7 1670000.0 0.94 1.286288E7 1021627.0967742 0.599873747368449 1.3879 0.9838 1667869 TimTec1_004442 Cc1ccccc1OCc2nnc(SCCC(=O)O)n2Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J21 compound treatment 1.139404E7 631000.0 0.35 1.276436E7 1550000.0 0.87 1.332872E7 1487467.0967742 0.873403284081473 1.2132 0.944 3212720 TimTec1_004443 OCCCc1nnc(S)n1CC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J22 compound treatment 1.093344E7 170000.0 0.1 1.171856E7 506000.0 0.28 1.21104E7 269147.0967742 0.158036408827714 0.3109 0.9157 3212721 TimTec1_004444 COc1ccc(/C=N/c2ccc3[nH]c(=O)[nH]c3c2)cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J23 mock treatment 1.117548E7 412000.0 0.23 1.20326E7 820000.0 0.46 1.244356E7 602307.0967742 0.353659585135698 0.6044 0.9656 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 J24 mock treatment 1.079008E7 26800.0 0.02 1.15498E7 337000.0 0.19 1.24942E7 652947.0967742 0.383394120038556 0.3397 0.7934 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K01 compound treatment 4227880.0 -6540000.0 -3.67 5516200.0 -5700000.0 -3.21 6433640.0 -5407612.9032258 -3.17521434858046 -5.8038 -0.9977 3084505 TimTec1_004445 O=C(OCCSC1=NS(=O)(=O)c2ccccc12)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K02 compound treatment 1.128844E7 525000.0 0.29 1.1163E7 -49500.0 -0.03 1.07682E7 -1073052.9032258 -0.630069688064396 -0.2096 -0.301 3084507 TimTec1_004446 Cc1cc(C)c(C#N)c(SCC(=O)OC=C)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K03 compound treatment 1.112172E7 358000.0 0.2 1.181564E7 603000.0 0.34 1.181388E7 -27372.9032258 -0.0160726806153261 0.303 0.7669 1649077 TimTec1_004447 O=C1OC2(CCCCC2)C(=C1)NCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K04 compound treatment 1.075788E7 -5440.0 0.0 1.178184E7 569000.0 0.32 1.1762E7 -79252.9032258 -0.0465353123443998 0.1564 0.4829 3212722 TimTec1_004448 CC1=NN(C(=O)c2ccc(Cl)cc2)C(C)(O)C1CC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K05 compound treatment 8968640.0 -1790000.0 -1.01 1.027692E7 -936000.0 -0.53 1.05264E7 -1314852.9032258 -0.772048569176386 -1.3318 -0.9688 3212723 TimTec1_004449 COc1ccc(/C=N/C2(CC3CC4CC(C3)C2)C4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K06 compound treatment 1.1409E7 646000.0 0.36 1.1849E7 637000.0 0.36 1.245884E7 617587.0967742 0.362631616994222 0.6256 1.0 1472188 TimTec1_004450 CCC(C)(N1CCC1=O)C(=O)Nc2cccc(C)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K07 compound treatment 1.122168E7 458000.0 0.26 1.129496E7 82500.0 0.05 1.122172E7 -619532.9032258 -0.363774145624738 -0.0346 -0.0772 3212724 TimTec1_004451 Cc1cccc2oc(nc12)c3ccc(/N=C/c4cc(ccc4O)C(=O)O)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K08 compound treatment 1.133612E7 573000.0 0.32 1.228956E7 1080000.0 0.61 1.240436E7 563107.0967742 0.330642330629535 0.7267 0.9538 1385208 TimTec1_004452 Cc1ccc(C)c(c1)S(=O)(=O)n2ccnc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K09 compound treatment 1.238696E7 1620000.0 0.91 1.20682E7 856000.0 0.48 1.267888E7 837627.0967742 0.491833573155852 1.0886 0.9527 1562045 TimTec1_004453 CN(c1c(C)n(C)n(c2ccccc2)c1=O)S(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K10 compound treatment 1.104424E7 281000.0 0.16 1.172588E7 513000.0 0.29 1.30192E7 1177947.0967742 0.691660921460369 0.6573 0.858 3084514 TimTec1_004454 Cc1cccc(NC(=O)c2cc(ccc2Cl)N3C(=O)C=CC3=O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K11 compound treatment 1.149496E7 732000.0 0.41 1.202724E7 815000.0 0.46 1.252232E7 681067.0967742 0.399905477097568 0.7329 0.9982 3212887 TimTec1_004455 CC(C)CN(C(=O)Nc1ccccc1)C2=NCC(C)S2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K12 compound treatment 1.1348E7 585000.0 0.33 1.230064E7 1090000.0 0.61 1.467228E7 2831027.0967742 1.66230793878298 1.503 0.8342 1735032 TimTec1_004456 COc1ccccc1Nc2nc3CCCCc3s2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K13 compound treatment 1.2534E7 1770000.0 0.99 1.289464E7 1680000.0 0.95 1.348964E7 1648387.0967742 0.967891462528708 1.6797 0.9998 1256975 TimTec1_004457 CCCCS(=O)C1CCCCC1OC(=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K14 compound treatment 1.186044E7 1100000.0 0.62 1.260836E7 1400000.0 0.79 1.286392E7 1022667.0967742 0.600484409222695 1.1561 0.9922 1277459 TimTec1_004458 COC(=O)CNc1nc(Cl)nc(n1)N2CCC(C)CC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K15 compound treatment 1.12644E7 501000.0 0.28 1.205296E7 840000.0 0.47 1.270232E7 861067.0967742 0.505596951870761 0.7276 0.9734 1916082 TimTec1_004459 CC(=O)NC1=NN(C(S1)c2ccccc2)C(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K16 compound treatment 1.151788E7 755000.0 0.42 1.195584E7 743000.0 0.42 1.230468E7 463427.0967742 0.272112740599581 0.6434 0.9826 1664793 TimTec1_004460 Cc1ccc(cc1)N2C(=C(C(C3=C2CC(C)(C)CC3)c4ccc(Cl)cc4)C(=O)N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K17 compound treatment 1.217596E7 1410000.0 0.79 1.194516E7 733000.0 0.41 1.272428E7 883027.0967742 0.518491311793091 0.9956 0.9631 1554613 TimTec1_004461 CSc1nsc(SC)c1NC(=O)N2CCCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K18 compound treatment 1.182924E7 1070000.0 0.6 1.181704E7 605000.0 0.34 1.288776E7 1046507.0967742 0.614482657881544 0.8969 0.9718 1119521 TimTec1_004462 O=C1NC(Nc2c1sc(=S)n2c3ccccc3)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K19 compound treatment 9935960.0 -827000.0 -0.46 9648120.0 -1560000.0 -0.88 9935480.0 -1905772.9032258 -1.11902193735958 -1.4228 -0.9499 1275123 TimTec1_004463 Nc1cc(nn1CC2CCCCC2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K20 compound treatment 1.06078E7 -156000.0 -0.09 1.076516E7 -447000.0 -0.25 1.106684E7 -774412.9032258 -0.454715787918472 -0.4583 -0.8696 1161548 TimTec1_004464 Cc1ccc(NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(c4ccccc4)c5ccccc5)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K21 compound treatment 1.12916E7 528000.0 0.3 1.202776E7 815000.0 0.46 1.233836E7 497107.0967742 0.291888789879365 0.6048 0.9762 1635937 TimTec1_004465 O=C(CSn1nnnc1c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K22 compound treatment 1.136912E7 606000.0 0.34 1.049284E7 -720000.0 -0.41 1.200116E7 159907.0967742 0.0938934271375828 0.0168 0.0312 3212796 TimTec1_004466 FC(F)(F)c1c2CCc3ccccc3-c2nc4cc(nn14)C(=O)N5CCCC5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K23 mock treatment 1.140392E7 641000.0 0.36 1.182972E7 617000.0 0.35 1.225516E7 413907.0967742 0.243035841539755 0.5487 0.9866 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 K24 mock treatment 1.071664E7 -46700.0 -0.03 1.103808E7 -174000.0 -0.1 1.147828E7 -362972.9032258 -0.213128563581346 -0.1949 -0.8253 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L01 compound treatment 1.045044E7 -313000.0 -0.18 1.076316E7 -449000.0 -0.25 1.070816E7 -1133092.9032258 -0.665323666649855 -0.6316 -0.8615 1434454 TimTec1_004467 CC(=O)Nc1ccc(Nc2cc(C)c3ccccc3n2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L02 compound treatment 1.0311E7 -452000.0 -0.25 1.087484E7 -338000.0 -0.19 1.105604E7 -785212.9032258 -0.461057276404863 -0.5226 -0.9337 1330869 TimTec1_004468 CN1CC[C@@H]2[C@@H](C1)c3cc(C)ccc3N2C(=O)c4ccc(C)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L03 compound treatment 1.067684E7 -86500.0 -0.05 1.132704E7 115000.0 0.06 1.177736E7 -63892.9032258 -0.0375163064970873 -0.0125 -0.14 3084523 TimTec1_004469 Cc1cc(=O)oc2cc(OC(=O)CSC(=N)N)ccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L04 compound treatment 1.137664E7 613000.0 0.34 1.277708E7 1560000.0 0.88 1.291436E7 1073107.0967742 0.630101509153583 1.0712 0.9426 1640717 TimTec1_004470 CCC(C(O)c1ccccc1)c2nc3ccccc3n2C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L05 compound treatment 1.097924E7 216000.0 0.12 1.231948E7 1110000.0 0.62 1.198364E7 142387.0967742 0.083606123592992 0.4781 0.7466 3084525 TimTec1_004471 Clc1cccc(c1)C(=O)OCC(=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L06 compound treatment 1.041244E7 -351000.0 -0.2 1.148868E7 276000.0 0.16 1.1503E7 -338252.9032258 -0.198613601045828 -0.1387 -0.4333 3212798 TimTec1_004472 CCSc1nc(c(C#N)c(=O)n1CC)c2ccc(Cl)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L07 compound treatment 1.302852E7 2270000.0 1.27 1.229636E7 1080000.0 0.61 1.248236E7 641107.0967742 0.376441969697919 1.3042 0.893 1227993 TimTec1_004473 CC1(C)C2CCC3(C)OC(=O)N(N1c4ccccc4)C23C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L08 compound treatment 1.131432E7 551000.0 0.31 1.24032E7 1190000.0 0.67 1.202768E7 186427.0967742 0.109465304420833 0.6289 0.8426 1742964 TimTec1_004474 CCOC(=O)N1CCN(CC1)C(=S)NC(=O)c2ccc(F)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L09 compound treatment 1.20724E7 1310000.0 0.74 1.287336E7 1660000.0 0.93 1.30982E7 1256947.0967742 0.738047735388604 1.3904 0.9933 1439010 TimTec1_004475 COc1ccc(CCNC(=O)C2C(C3CC2C=C3)C(=O)O)cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L10 compound treatment 1.242728E7 1660000.0 0.93 1.18966E7 684000.0 0.39 1.253092E7 689667.0967742 0.404955180892287 0.9957 0.9144 3084528 TimTec1_004476 CC1(C)CC(NC(=O)C(F)(F)F)C(NC(=O)C(F)(F)F)C(C)(C)N1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L11 compound treatment 1.17078E7 944000.0 0.53 1.257344E7 1360000.0 0.77 1.283188E7 990627.0967742 0.581671326713066 1.0844 0.9872 3212799 TimTec1_004477 NC(=O)/C(=N/O)/C1=NC2(CCCCC2)Cc3ccccc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L12 compound treatment 1.175784E7 995000.0 0.56 1.28052E7 1590000.0 0.9 1.380432E7 1963067.0967742 1.15266364742664 1.5056 0.963 1441377 TimTec1_004478 Clc1ccc(cc1)c2ccc(o2)C(=S)N3CCN(CC3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L13 compound treatment 1.40316E7 3270000.0 1.84 1.440092E7 3190000.0 1.79 1.381512E7 1973867.0967742 1.15900513591304 2.7653 0.9817 1208093 TimTec1_004479 CN(C)CCOC(=O)C1(CC2c3ccccc3C1c4ccccc24)C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L14 compound treatment 1.23674E7 1600000.0 0.9 1.301984E7 1810000.0 1.02 1.31446E7 1303347.0967742 0.765292648885694 1.5494 0.9934 3084551 TimTec1_004480 CCOC(=O)c1c(O)c(Cl)c(C)[nH]c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L15 compound treatment 1.191076E7 1150000.0 0.64 1.27838E7 1570000.0 0.88 1.407088E7 2229627.0967742 1.30918097806855 1.6386 0.9603 1150863 TimTec1_004481 CCOC(=O)c1c(C)c([nH]c1CN2CCOCC2)C(=O)OCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L16 compound treatment 1.244996E7 1690000.0 0.95 1.306228E7 1850000.0 1.04 1.265344E7 812187.0967742 0.476895844721241 1.4235 0.9577 3212800 TimTec1_004482 CC(=O)N1N=C(CC1c2ccc(F)cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L17 compound treatment 1.270712E7 1940000.0 1.09 1.285076E7 1640000.0 0.92 1.358324E7 1741987.0967742 1.02285102941077 1.7533 0.9976 1417256 TimTec1_004483 OCCNC(=O)c1c2CCCCc2nc3ccccc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L18 compound treatment 1.1622E7 859000.0 0.48 1.316364E7 1950000.0 1.1 1.323492E7 1393667.0967742 0.818326282227443 1.385 0.9538 1332505 TimTec1_004484 NNc1nnc2c3ccccc3[nH]c2n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L19 compound treatment 1.200164E7 1240000.0 0.7 1.284452E7 1630000.0 0.92 1.328044E7 1439187.0967742 0.845054481847864 1.4199 0.9936 1647319 TimTec1_004485 COc1ccc(cc1)C2OC(=O)Cc3cc(OC)c(OC)cc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L20 compound treatment 1.150868E7 745000.0 0.42 1.200744E7 795000.0 0.45 1.235868E7 517427.0967742 0.303820183031538 0.6755 0.9876 3084552 TimTec1_004486 O=c1nc(SCCOc2ccccc2)[nH]c3ccccc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L21 compound treatment 1.12458E7 482000.0 0.27 1.16942E7 482000.0 0.27 1.261792E7 776667.0967742 0.456039393699331 0.5763 0.9673 3212801 TimTec1_004487 CC(=O)Nc1ccc2nc(C)sc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L22 compound treatment 1.064988E7 -113000.0 -0.06 1.149536E7 283000.0 0.16 1.224156E7 400307.0967742 0.235050263445781 0.1909 0.6559 1262531 TimTec1_004488 Nc1nonc1c2noc(n2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L23 mock treatment 1.10066E7 243000.0 0.14 1.092996E7 -283000.0 -0.16 1.271656E7 875307.0967742 0.513958321875041 0.2838 0.5113 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 L24 mock treatment 1.091644E7 153000.0 0.09 1.070144E7 -511000.0 -0.29 1.17464E7 -94852.9032258 -0.0556952401580765 -0.1486 -0.4866 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M01 compound treatment 9716520.0 -1050000.0 -0.59 1.103232E7 -180000.0 -0.1 1.114908E7 -692172.9032258 -0.406426527444319 -0.6327 -0.8764 3212802 TimTec1_004489 CCCc1c(C#N)c(N)[nH]c(=S)c1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M02 compound treatment 7224200.0 -3540000.0 -1.99 7436120.0 -3780000.0 -2.13 7902640.0 -3938612.9032258 -2.31265447945924 -3.7102 -0.9981 3084553 TimTec1_004490 N#Cc1ccc(nc1SCc2ccncc2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M03 compound treatment 1.071344E7 -49900.0 -0.03 1.15588E7 346000.0 0.19 1.178464E7 -56612.9032258 -0.0332416735173715 0.0772 0.3865 1912735 TimTec1_004491 CCSc1nc(C)cc(COC)c1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M04 compound treatment 9001200.0 -1760000.0 -0.99 1.004284E7 -1170000.0 -0.66 1.072216E7 -1119092.9032258 -0.65710321861194 -1.3309 -0.9799 1677912 TimTec1_004492 OC(C1CCCN1Cc2ccccc2)(c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M05 compound treatment 1.12698E7 506000.0 0.28 1.198756E7 775000.0 0.44 1.247268E7 631427.0967742 0.370758117054561 0.6302 0.9857 1303390 TimTec1_004493 CNC(=O)C(NS(=O)(=O)c1ccc(C)cc1)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M06 compound treatment 1.159828E7 835000.0 0.47 1.219204E7 980000.0 0.55 1.276856E7 927307.0967742 0.544491414587296 0.9035 0.9974 1611737 TimTec1_004494 CC1CN(C)CC(C1)(OC(=O)C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M07 compound treatment 1.13058E7 542000.0 0.3 1.278736E7 1570000.0 0.89 1.280324E7 961987.0967742 0.564854638726932 1.0139 0.9264 1011962 TimTec1_004495 OC(=O)CCC(=O)Nc1ccc2ccccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M08 compound treatment 1.055232E7 -211000.0 -0.12 1.117064E7 -41800.0 -0.02 1.248312E7 641867.0967742 0.376888222591406 0.1356 0.3426 1708192 TimTec1_004496 CCOC(=O)c1[nH]c(C)c(C(=O)C(C)C)c1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M09 compound treatment 1.142776E7 664000.0 0.37 1.284392E7 1630000.0 0.92 1.301584E7 1174587.0967742 0.68968801393127 1.1439 0.9472 1647225 TimTec1_004497 CC1CCN(CC1)c2nc(nc(n2)N3CCC(C)CC3)N4CCC(C)CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M10 compound treatment 1.075256E7 -10800.0 -0.01 1.206344E7 851000.0 0.48 1.187892E7 37667.0967742 0.0221171722693877 0.2858 0.596 3212803 TimTec1_004498 COc1cccc(OCCNC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M11 compound treatment 1.187852E7 1120000.0 0.63 1.282228E7 1610000.0 0.91 1.336616E7 1524907.0967742 0.895387110834298 1.4018 0.9875 3084554 TimTec1_004499 Oc1ccccc1/C=N/c2nc[nH]n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M12 compound treatment 1.194536E7 1180000.0 0.66 1.270208E7 1490000.0 0.84 1.311316E7 1271907.0967742 0.746831871291976 1.2986 0.9955 3212804 TimTec1_004500 CCSc1nsc(SCC)c1C(=O)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M13 compound treatment 1.286952E7 2110000.0 1.18 1.458944E7 3380000.0 1.9 1.392312E7 2081867.0967742 1.22242002077695 2.4863 0.9746 3212805 TimTec1_004501 CSc1nnc2n(/N=C/c3cc4OCOc4cc3Br)cnn12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M14 compound treatment 1.200096E7 1240000.0 0.7 1.289096E7 1680000.0 0.94 1.3876E7 2034747.0967742 1.19475234138077 1.6366 0.9775 1631850 TimTec1_004502 O=c1[nH]cc(COCc2ccccc2)c(=O)[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M15 compound treatment 1.197776E7 1210000.0 0.68 1.29222E7 1710000.0 0.96 1.310792E7 1266667.0967742 0.743755075026356 1.3789 0.9888 1119024 TimTec1_004503 CC(C)(C)NC1=CC(=O)OC21CCCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M16 compound treatment 1.237972E7 1620000.0 0.91 1.260868E7 1400000.0 0.79 1.306956E7 1228307.0967742 0.721231047402469 1.3943 0.9954 3212806 TimTec1_004504 COC(=O)c1cccc(NC(=O)COC(=O)CSc2nc(C)cc(C)n2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M17 compound treatment 1.089232E7 129000.0 0.07 1.248948E7 1280000.0 0.72 1.226792E7 426667.0967742 0.250528192751455 0.6015 0.7866 3212807 TimTec1_004505 NC(=O)CSc1nsc(SCc2ccc(Cl)cc2)c1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M18 compound treatment 1.151004E7 747000.0 0.42 1.249692E7 1280000.0 0.72 1.267284E7 831587.0967742 0.488287037002352 0.9415 0.9726 1558723 TimTec1_004506 CC(=O)NC(Cc1ccc(F)cc1)C(=O)OCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M19 compound treatment 1.033524E7 -428000.0 -0.24 1.207084E7 858000.0 0.48 1.0976E7 -865252.9032258 -0.508054752187343 -0.1532 -0.2067 1121754 TimTec1_004507 CCOC(=O)c1cnn(CC2CCCCC2)c1N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M20 compound treatment 1.129172E7 528000.0 0.3 1.21834E7 971000.0 0.55 1.239732E7 556067.0967742 0.326508619616184 0.6754 0.9615 1392807 TimTec1_004508 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC3CCCCC3)C(c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M21 compound treatment 1.064688E7 -116000.0 -0.07 1.080472E7 -408000.0 -0.23 1.16842E7 -157052.9032258 -0.0922175164408133 -0.2235 -0.8736 3084555 TimTec1_004509 CSc1nc2ccc(/N=C/c3ccc(Sc4nnnn4c5ccccc5)o3)cc2s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M22 compound treatment 1.028064E7 -483000.0 -0.27 1.06362E7 -576000.0 -0.32 7618640.0 -4222612.9032258 -2.47941213965694 -1.7753 -0.7058 1691433 TimTec1_004510 Clc1ccc(NC(=O)C2C3CCC=CCCC23)cc1Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M23 mock treatment 1.117676E7 413000.0 0.23 1.171364E7 501000.0 0.28 1.199536E7 154107.0967742 0.0904878129504466 0.3492 0.9276 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 M24 mock treatment 1.053148E7 -232000.0 -0.13 1.046588E7 -747000.0 -0.42 1.162712E7 -214132.9032258 -0.125733457441113 -0.3904 -0.8532 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N01 compound treatment 1.13246E7 561000.0 0.32 1.145512E7 243000.0 0.14 1.181616E7 -25092.9032258 -0.0147339219348657 0.2524 0.7339 3084556 TimTec1_004511 FC(F)(F)c1ccccc1/C=C\2/SC(=N)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N02 compound treatment 1.717684E7 6410000.0 3.6 1.260368E7 1390000.0 0.78 1.360384E7 1762587.0967742 1.0349468315237 3.1295 0.8173 1558366 TimTec1_004512 O=C(N1CCCCCC1)c2cc3ccccc3c(=O)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N03 compound treatment 1.251612E7 1750000.0 0.98 1.305564E7 1840000.0 1.04 1.340492E7 1563667.0967742 0.918146008402125 1.6975 0.9988 1395140 TimTec1_004513 Cc1ccc2[nH]c(SCC(=O)O)nc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N04 compound treatment 1.643576E7 5670000.0 3.19 1.432988E7 3120000.0 1.75 1.455184E7 2710587.0967742 1.59158859866252 3.7716 0.9499 3212808 TimTec1_004514 Clc1c(sc2ccccc12)C(=O)n3cccn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N05 compound treatment 1.498392E7 4220000.0 2.37 1.333256E7 2120000.0 1.19 1.388648E7 2045227.0967742 1.20090593391201 2.7511 0.9444 3084561 TimTec1_004515 Cc1nn(C(=O)Cc2ccc(Cl)cc2)c(C)c1Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N06 compound treatment 1.688404E7 6120000.0 3.44 1.296368E7 1750000.0 0.99 1.31524E7 1311147.0967742 0.769872612792532 2.9985 0.8196 1622238 TimTec1_004516 Nc1ccc(cc1F)c2nnn[nH]2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N07 compound treatment 1.704064E7 6280000.0 3.53 1.359396E7 2380000.0 1.34 1.325516E7 1413907.0967742 0.830210701390828 3.289 0.8515 3084563 TimTec1_004517 CCNc1nnc(CSc2nc3ccccc3s2)s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N08 compound treatment 1.218472E7 1420000.0 0.8 1.546064E7 4250000.0 2.39 1.373372E7 1892467.0967742 1.11120910232116 2.4831 0.9013 1261617 TimTec1_004518 CC(=C)CSC1=C(C#N)C(C)(C)C(C#N)C(=O)N1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N09 compound treatment 1.153996E7 777000.0 0.44 1.3984E7 2770000.0 1.56 1.446792E7 2626667.0967742 1.54231288442382 2.0431 0.9134 3212888 TimTec1_004519 COc1cccc(c1)C2C(=C(N)Oc3c2c(C)nn3c4ccccc4)C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N10 compound treatment 1.4504E7 3740000.0 2.1 1.383256E7 2620000.0 1.47 1.376664E7 1925387.0967742 1.13053889870746 2.7173 0.9687 1151574 TimTec1_004520 COc1cccc(c1)N2C(=O)NC(=O)C(CCc3ccncc3)(CCc4ccncc4)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N11 compound treatment 1.483112E7 4070000.0 2.28 1.31776E7 1970000.0 1.11 1.53856E7 3544347.0967742 2.08115150981195 3.1594 0.9625 3212889 TimTec1_004521 CCOC1CC(C)(C)NC(=S)N1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N12 compound treatment 1.436556E7 3600000.0 2.02 1.764152E7 6430000.0 3.62 1.606336E7 4222107.0967742 2.47911514282461 4.6889 0.9706 1367122 TimTec1_004522 OC1CCN(C2CCCCC12)S(=O)(=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N13 compound treatment 1.338736E7 2620000.0 1.47 1.733984E7 6130000.0 3.45 1.72E7 5358747.0967742 3.14652157552574 4.659 0.9516 1402632 TimTec1_004523 CCCn1c(nc2ccccc12)c3nonc3N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N14 compound treatment 1.237772E7 1610000.0 0.91 1.41846E7 2970000.0 1.67 1.815148E7 6310227.0967742 3.70520671117683 3.6287 0.8712 1157736 TimTec1_004524 CCOC(=O)c1cc(C(=O)NC(C)c2ccccc2)c(C)[nH]c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N15 compound treatment 1.268536E7 1920000.0 1.08 1.381688E7 2600000.0 1.47 1.4061E7 2219747.0967742 1.30337969045322 2.2222 0.9925 1611714 TimTec1_004525 COC(=O)C(C(=O)OC)c1ccc(C#N)c(C#N)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N16 compound treatment 9961680.0 -802000.0 -0.45 1.221728E7 1000000.0 0.57 1.15942E7 -247052.9032258 -0.14506325382741 -0.0171 -0.0233 3212890 TimTec1_004526 COc1ccc(cc1)N(/N=C/2\Oc3ccc4c(C)cc(=O)oc4c3C2=O)C(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N17 compound treatment 6419800.0 -4340000.0 -2.44 7348200.0 -3860000.0 -2.18 6997800.0 -4843452.9032258 -2.84395377964688 -4.3064 -0.9939 1271644 TimTec1_004527 OC1(CSC2=C(C#N)C(CC(=O)N21)c3cccs3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N18 compound treatment 1.152856E7 765000.0 0.43 1.175008E7 538000.0 0.3 1.311936E7 1278107.0967742 0.750472355423053 0.8562 0.9344 1486726 TimTec1_004528 CCCS(=O)(=O)c1c(C(=O)c2ccc(C)cc2)n3cccc(N)c3c1S(=O)(=O)CCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N19 compound treatment 1.172728E7 964000.0 0.54 1.323516E7 2020000.0 1.14 1.317968E7 1338427.0967742 0.785890742969269 1.4237 0.9583 3084570 TimTec1_004529 Cc1nnnn1CC(=O)Nc2ccc(F)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N20 compound treatment 1.120896E7 446000.0 0.25 1.27478E7 1540000.0 0.86 1.5159E7 3317747.0967742 1.9480976865697 1.7682 0.824 1252602 TimTec1_004530 COc1ccc(Br)cc1S(=O)(=O)NCc2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N21 compound treatment 1.206564E7 1300000.0 0.73 8952360.0 -2260000.0 -1.27 1.421232E7 2371067.0967742 1.39223099024588 0.4916 0.243 3212891 TimTec1_004531 CCOC(=O)C1=C(OC(=C(C#N)C1c2ccc(F)cc2)N)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N22 compound treatment 1.1141E7 378000.0 0.21 1.255684E7 1340000.0 0.76 1.33674E7 1526147.0967742 0.896115207660513 1.0768 0.9034 1565486 TimTec1_004532 COc1cc(Oc2ccccc2CC=C)nc(N)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N23 mock treatment 1.098156E7 218000.0 0.12 1.24916E7 1280000.0 0.72 1.323184E7 1390587.0967742 0.816517783659101 0.9579 0.8744 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 N24 mock treatment 1.09268E7 163000.0 0.09 1.183992E7 627000.0 0.35 1.240912E7 567867.0967742 0.333437282962427 0.4494 0.9092 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O01 compound treatment 8878280.0 -1890000.0 -1.06 9443440.0 -1770000.0 -1.0 1.123996E7 -601292.9032258 -0.353064076181054 -1.3901 -0.9293 1618653 TimTec1_004533 Cc1ccc(cc1C)C(=O)c2cccc(N)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O02 compound treatment 8777320.0 -1990000.0 -1.12 8282360.0 -2930000.0 -1.65 8285440.0 -3555812.9032258 -2.08788394310825 -2.8017 -0.9711 3212892 TimTec1_004534 COC(=O)c1c(C)[nH]c(C)c1c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O03 compound treatment 1.553104E7 4770000.0 2.68 1.2533E7 1320000.0 0.74 1.372096E7 1879707.0967742 1.10371675110946 2.6125 0.8737 3084586 TimTec1_004535 CSc1nnc2n(/N=C/c3c[nH]c4ccccc34)cnn12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O04 compound treatment 1.082912E7 65800.0 0.04 1.261788E7 1410000.0 0.79 1.609456E7 4253307.0967742 2.49743499845197 1.92 0.7328 3212893 TimTec1_004536 NC(=O)[C@@H]1[C@@H](c2ccc(Cl)cc2)C1(C#N)C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O05 compound treatment 1.201904E7 1260000.0 0.71 1.429588E7 3080000.0 1.74 1.338816E7 1546907.0967742 0.908304957751021 1.9337 0.9287 1780136 TimTec1_004537 CCOC(=O)c1c(C)cc(C)[nH]c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O06 compound treatment 1.180072E7 1040000.0 0.58 1.224072E7 1030000.0 0.58 1.271728E7 876027.0967742 0.514381087774133 0.9676 0.9984 1363495 TimTec1_004538 CN(Cn1nc(O)ccc1=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O07 compound treatment 7659760.0 -3100000.0 -1.74 7908520.0 -3300000.0 -1.86 7894680.0 -3946572.9032258 -2.31732839134365 -3.4181 -0.9922 3084613 TimTec1_004539 NC1=NN(CC1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O08 compound treatment 1.0234E7 -529000.0 -0.3 1.257552E7 1360000.0 0.77 1.30714E7 1230147.0967742 0.722311449144595 0.6884 0.6287 1493858 TimTec1_004540 COc1ccc(cc1OC)C2=C(N)C(=O)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O09 compound treatment 1.15204E7 757000.0 0.43 1.28166E7 1600000.0 0.9 1.289676E7 1055507.0967742 0.619767231620204 1.1247 0.9573 3212894 TimTec1_004541 Cc1ccccc1/C=N/N2C(=O)c3ccc4CCc5ccc(C2=O)c3c45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O10 compound treatment 6804440.0 -3960000.0 -2.22 7305360.0 -3910000.0 -2.2 7668720.0 -4172532.9032258 -2.4500064226756 -3.9681 -0.9988 1029950 TimTec1_004542 CN(C)c1ccc(cc1)C(=NO)c2ccc(cc2)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O11 compound treatment 1.213056E7 1370000.0 0.77 1.300252E7 1790000.0 1.01 1.344696E7 1605707.0967742 0.942830839510264 1.5695 0.9938 1641866 TimTec1_004543 Cc1cc(C)c(cc1S(=O)(=O)N)S(=O)(=O)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O12 compound treatment 1.079332E7 30000.0 0.02 1.084332E7 -369000.0 -0.21 9988160.0 -1853092.9032258 -1.08808956574263 -0.7384 -0.6665 3212895 TimTec1_004544 O=C(CSc1ccccn1)Nc2sc3CCCCc3c2C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O13 compound treatment 1.144208E7 679000.0 0.38 1.334512E7 2130000.0 1.2 1.445724E7 2615987.0967742 1.53604185692061 1.8001 0.9062 3084617 TimTec1_004545 O=C(CSc1ncn[nH]1)Nc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O14 compound treatment 1.449736E7 3730000.0 2.1 1.734712E7 6130000.0 3.45 1.393792E7 2096667.0967742 1.23111020870275 3.9154 0.927 1421449 TimTec1_004546 NC(=O)Cc1ccc(NC(=O)CCC(=O)O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O15 compound treatment 1.185336E7 1090000.0 0.61 1.282816E7 1620000.0 0.91 1.292636E7 1085107.0967742 0.637147607471796 1.2464 0.9829 1919218 TimTec1_004547 OC(=O)CCCC(=O)Nc1cccc(c1)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O16 compound treatment 9719720.0 -1040000.0 -0.59 1.035392E7 -859000.0 -0.48 1.001952E7 -1821732.9032258 -1.0696757621377 -1.235 -0.9413 3084620 TimTec1_004548 FC(F)(F)c1cccc(c1)N2CCN(CC2)C(=S)Nc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O17 compound treatment 1.14494E7 686000.0 0.39 1.176108E7 549000.0 0.31 1.185044E7 9187.09677419998 0.00539443226082912 0.4039 0.8178 1239543 TimTec1_004549 O=C(CSc1nc2ccccc2o1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O18 compound treatment 1.142228E7 659000.0 0.37 1.239264E7 1180000.0 0.66 1.278004E7 938787.0967742 0.551232181978387 0.9155 0.9747 1529100 TimTec1_004550 CCn1cc(c(C#N)c1NC(=O)C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O19 compound treatment 1.071968E7 -43600.0 -0.02 1.27502E7 1540000.0 0.87 1.218724E7 345987.0967742 0.203154925058671 0.6029 0.6778 3084622 TimTec1_004551 Clc1ccc(OCCNC(=O)c2cccs2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O20 compound treatment 1.148984E7 727000.0 0.41 1.210372E7 891000.0 0.5 1.226476E7 423507.0967742 0.248672720194326 0.6688 0.9653 1322941 TimTec1_004552 Cc1cc(C)n(NC2=CC(=O)CC(C)(C)C2)c(=O)c1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O21 compound treatment 1.129892E7 536000.0 0.3 1.176952E7 557000.0 0.31 1.210684E7 265587.0967742 0.155946066326644 0.4448 0.9634 3212896 TimTec1_004553 CCN/C(=N/CC)/SC1CC(=O)N(C1=O)c2ccc(OCC)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O22 compound treatment 1.110512E7 342000.0 0.19 1.1585E7 373000.0 0.21 1.182728E7 -13972.9032258 -0.00820453749332173 0.2272 0.7987 3084625 TimTec1_004554 Nc1nc(nc2c3ccccc3oc(=O)c12)c4cccnc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O23 mock treatment 1.104952E7 286000.0 0.16 1.217264E7 960000.0 0.54 1.247092E7 629667.0967742 0.369724689301223 0.6183 0.917 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 O24 mock treatment 1.030684E7 -456000.0 -0.26 1.032828E7 -884000.0 -0.5 1.075452E7 -1086732.9032258 -0.638102240147159 -0.8038 -0.9469 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P01 compound treatment 9135160.0 -1630000.0 -0.91 9847280.0 -1370000.0 -0.77 9314400.0 -2526852.9032258 -1.48370449931589 -1.8283 -0.9598 1465751 TimTec1_004555 O=C(Cc1ccccc1)Nc2ccc3oc(nc3c2)c4ccncc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P02 compound treatment 9648440.0 -1110000.0 -0.63 9646800.0 -1570000.0 -0.88 1.00068E7 -1834452.9032258 -1.077144626355 -1.4923 -0.9778 1350858 TimTec1_004556 Cc1cccc(C)c1N2CCc3cn[nH]c23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P03 compound treatment 1.10386E7 275000.0 0.15 1.234596E7 1130000.0 0.64 1.158596E7 -255292.9032258 -0.149901574672583 0.3711 0.5511 1593678 TimTec1_004557 COc1ccc(CCC(O)C2(O)CCCCC2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P04 compound treatment 1.008188E7 -681000.0 -0.38 1.040752E7 -805000.0 -0.45 1.07292E7 -1112052.9032258 -0.652969507598588 -0.8596 -0.9744 1664967 TimTec1_004558 Clc1ccc(NC(=O)CC2SCCNC2=O)cc1Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P05 compound treatment 1.159436E7 831000.0 0.47 1.19594E7 747000.0 0.42 1.173224E7 -109012.9032258 -0.0640096361735677 0.4753 0.7527 1438867 TimTec1_004559 O=C1N(CC2CCCO2)C(=O)c3cc(ccc13)c4nc5ccccc5c(=O)o4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P06 compound treatment 1.03548E7 -409000.0 -0.23 1.096236E7 -250000.0 -0.14 1.155288E7 -288372.9032258 -0.169325319036456 -0.3115 -0.9795 1740022 TimTec1_004560 CC1CN(Cn2nc(c3ccccc3)n(CC=C)c2=S)CC(C)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P07 compound treatment 1.141292E7 650000.0 0.36 1.185244E7 640000.0 0.36 1.215412E7 312867.0967742 0.183707693700403 0.5247 0.9634 1430817 TimTec1_004561 O=C(CSCc1ccccc1)Nc2nnc(Cc3ccccc3)s2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P08 compound treatment 1.028744E7 -476000.0 -0.27 1.0103E7 -1110000.0 -0.62 1.083692E7 -1004332.9032258 -0.58971903169543 -0.8554 -0.9508 1573254 TimTec1_004562 CC(CN1CCNCC1)(NS(=O)(=O)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P09 compound treatment 1.123592E7 473000.0 0.27 1.199648E7 784000.0 0.44 1.2493E7 651747.0967742 0.382689510206735 0.629 0.9803 1431707 TimTec1_004563 COc1cc2C(CC(=O)Nc3ccccc3)C(=O)N(N=C(C)c2cc1OC)C(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P10 compound treatment 1.117636E7 413000.0 0.23 1.180852E7 596000.0 0.34 1.24358E7 594547.0967742 0.349103108223253 0.5292 0.9857 1386480 TimTec1_004564 CC(C)CNC(=O)c1cccc(NC(=O)CC(C)C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P11 compound treatment 9922600.0 -841000.0 -0.47 1.052572E7 -687000.0 -0.39 1.049252E7 -1348732.9032258 -0.79194205342814 -0.953 -0.9532 3212897 TimTec1_004565 C=CC/N=C(\SCc1ccccc1)/N2CCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P12 compound treatment 1.07646E7 1290.0 0.0 1.126256E7 50100.0 0.03 1.13708E7 -470452.9032258 -0.27623811751814 -0.1428 -0.5142 1213970 TimTec1_004566 CC(=O)Oc1coc2ccc3c(C)cc(=O)oc3c12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P13 compound treatment 1.106744E7 304000.0 0.17 1.211648E7 904000.0 0.51 1.233728E7 496027.0967742 0.291254641030726 0.5606 0.9179 1578888 TimTec1_004567 Clc1ccc(cc1)C(NC(=O)c2ccccc2Cl)C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P14 compound treatment 1.082648E7 63200.0 0.04 1.154008E7 328000.0 0.18 1.138116E7 -460092.9032258 -0.270154985970082 -0.029 -0.0882 1291706 TimTec1_004568 COC(=O)C1=C(C)NC(=C(C#N)C1c2cccnc2)S 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P15 compound treatment 7944320.0 -2820000.0 -1.58 8480560.0 -2730000.0 -1.54 8786680.0 -3054572.9032258 -1.79356841635649 -2.8375 -0.9977 3212898 TimTec1_004569 CCSc1cccc2cccnc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P16 compound treatment 1.11414E7 378000.0 0.21 1.145168E7 239000.0 0.13 1.189952E7 58267.0967742 0.0342129743823198 0.2201 0.8673 1230586 TimTec1_004570 CC(=O)Nc1cc2c(C)cc(=O)oc2c3C(=O)COc31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P17 compound treatment 1.10314E7 268000.0 0.15 1.012784E7 -1080000.0 -0.61 1.213548E7 294227.0967742 0.172762754312779 -0.1658 -0.2543 3085776 TimTec1_004571 CCc1nnc(NC(=O)COC(=O)CSc2nc(cc(n2)c3ccccc3)c4ccccc4)s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P18 compound treatment 1.051812E7 -245000.0 -0.14 1.129164E7 79200.0 0.04 1.148084E7 -360412.9032258 -0.211625395940127 -0.176 -0.6863 1673944 TimTec1_004572 Cc1nn2cc(nc2s1)c3ccc(N)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P19 compound treatment 1.134172E7 578000.0 0.32 1.092288E7 -290000.0 -0.16 1.181784E7 -23412.9032258 -0.0137474681703159 0.0855 0.2351 3212899 TimTec1_004573 O=C(CSC1=NC(=O)C(Cc2ccccc2)C(=O)N1)NCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P20 compound treatment 1.052616E7 -237000.0 -0.13 1.102596E7 -187000.0 -0.1 1.183232E7 -8932.90322580002 -0.00524517619967233 -0.1405 -0.8283 3085777 TimTec1_004574 CCOC(=O)C1NCCc2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P21 compound treatment 1.129424E7 531000.0 0.3 1.182756E7 615000.0 0.35 1.18272E7 -14052.9032258 -0.00825151148210982 0.3673 0.8037 1311348 TimTec1_004575 CCC(=O)Oc1ccc2c3CCCc3c(=O)oc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P22 compound treatment 5879480.0 -4880000.0 -2.74 6317440.0 -4900000.0 -2.76 6728800.0 -5112452.9032258 -3.00190381694682 -4.9078 -0.9991 1265079 TimTec1_004576 COc1ccc2nc(C)c3CC(C)Oc3c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P23 mock treatment 1.06692E7 -94100.0 -0.05 1.037732E7 -835000.0 -0.47 1.006244E7 -1778812.9032258 -1.04447421715289 -0.905 -0.7893 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2075 P24 mock treatment 8013720.0 -2750000.0 -1.54 8748560.0 -2460000.0 -1.39 9164840.0 -2676412.9032258 -1.57152237135521 -2.5997 -0.9985 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A01 compound treatment 7642400.0 -5880000.0 -3.31 6632240.0 -4750000.0 -2.67 6904760.0 -5099286.25 -2.99417268918425 -5.1801 -0.9963 3070297 PK04_103001 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A02 compound treatment 8095160.0 -5430000.0 -3.05 7433360.0 -3950000.0 -2.22 7620640.0 -4383406.25 -2.57382595051407 -4.5303 -0.9917 3189402 PK04_103002 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A03 compound treatment 1.0453E7 -3070000.0 -1.73 9357080.0 -2020000.0 -1.14 9310160.0 -2693886.25 -1.58178228129848 -2.5677 -0.9861 3070298 PK04_103003 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A04 compound treatment 1.147476E7 -2050000.0 -1.15 9888280.0 -1490000.0 -0.84 1.011468E7 -1889366.25 -1.1093883630511 -1.791 -0.9912 3189403 PK04_103004 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A05 compound treatment 1.1005E7 -2520000.0 -1.42 9981520.0 -1400000.0 -0.79 9750360.0 -2253686.25 -1.32330790799204 -2.0365 -0.9733 3070299 PK04_103005 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A06 compound treatment 1.216784E7 -1360000.0 -0.76 1.05086E7 -872000.0 -0.49 1.120936E7 -794686.25 -0.466619787469325 -0.9935 -0.9736 3189404 PK04_103006 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccc(OCCO)cc3)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A07 compound treatment 1.121376E7 -2310000.0 -1.3 1.024088E7 -1140000.0 -0.64 1.061164E7 -1392406.25 -0.817585944699508 -1.5925 -0.9572 3070300 PK04_103007 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A08 compound treatment 1.230676E7 -1220000.0 -0.69 1.04234E7 -957000.0 -0.54 1.095072E7 -1053326.25 -0.618486693221206 -1.0638 -0.9953 3189405 PK04_103008 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A09 compound treatment 1.129852E7 -2230000.0 -1.25 9967520.0 -1410000.0 -0.8 1.078332E7 -1220726.25 -0.716779764760276 -1.5957 -0.9688 3189406 PK04_103009 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A10 compound treatment 1.205936E7 -1470000.0 -0.82 1.038428E7 -996000.0 -0.56 1.130756E7 -696486.25 -0.408959216231949 -1.0358 -0.9612 3070355 PK04_103010 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A11 compound treatment 1.143388E7 -2090000.0 -1.18 9525800.0 -1850000.0 -1.04 9934760.0 -2069286.25 -1.2150328638355 -1.983 -0.998 3189407 PK04_103011 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A12 compound treatment 1.139192E7 -2140000.0 -1.2 9921280.0 -1460000.0 -0.82 1.037392E7 -1630126.25 -0.957169152383305 -1.7192 -0.9878 3189408 PK04_103012 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccc(CO)o2)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A13 mock treatment 1.29732E7 -554000.0 -0.31 1.15192E7 139000.0 0.08 1.176216E7 -241886.25 -0.142029524943652 -0.2165 -0.6172 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A14 mock treatment 1.283872E7 -688000.0 -0.39 1.093608E7 -444000.0 -0.25 1.172392E7 -280126.25 -0.164483091584357 -0.4626 -0.9461 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A15 compound treatment 1.032328E7 -3200000.0 -1.8 8216120.0 -3160000.0 -1.78 8159800.0 -3844246.25 -2.25724475307676 -3.3705 -0.9937 3070356 PK04_103013 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A16 compound treatment 1.189792E7 -1630000.0 -0.92 1.069644E7 -684000.0 -0.39 1.093548E7 -1068566.25 -0.627435238085337 -1.1128 -0.9476 3189409 PK04_103014 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A17 compound treatment 1.1033E7 -2490000.0 -1.4 9800120.0 -1580000.0 -0.89 1.01136E7 -1890446.25 -1.11002251189974 -1.9632 -0.9834 3070357 PK04_103015 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A18 compound treatment 1.058436E7 -2940000.0 -1.65 9219720.0 -2160000.0 -1.22 9701200.0 -2302846.25 -1.35217342410232 -2.4372 -0.9917 3189410 PK04_103016 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A19 compound treatment 7983040.0 -5540000.0 -3.11 7121440.0 -4260000.0 -2.4 7310040.0 -4694006.25 -2.75620246198381 -4.7733 -0.9944 3070358 PK04_103017 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A20 compound treatment 1.103908E7 -2490000.0 -1.4 9737560.0 -1640000.0 -0.92 1.00756E7 -1928446.25 -1.13233515657408 -1.9945 -0.9862 3189411 PK04_103018 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccccc2OCCO)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A21 compound treatment 1.10502E7 -2480000.0 -1.39 9745960.0 -1630000.0 -0.92 1.05394E7 -1464646.25 -0.86000345657515 -1.8309 -0.9757 3070359 PK04_103019 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A22 compound treatment 9757560.0 -3770000.0 -2.12 8258120.0 -3120000.0 -1.76 8874760.0 -3129286.25 -1.83743821527764 -3.298 -0.9967 3189412 PK04_103020 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A23 compound treatment 1.071268E7 -2810000.0 -1.58 9506320.0 -1870000.0 -1.05 9859120.0 -2144926.25 -1.25944677023464 -2.2489 -0.9864 3070360 PK04_103021 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 A24 compound treatment 9925840.0 -3600000.0 -2.02 9367200.0 -2010000.0 -1.13 1.12118E7 -792246.25 -0.465187080811288 -2.0907 -0.8841 3189413 PK04_103022 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B01 compound treatment 1.090376E7 -2620000.0 -1.47 9936200.0 -1440000.0 -0.81 9882760.0 -2121286.25 -1.24556595654776 -2.0392 -0.974 3189525 PK04_103023 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B02 compound treatment 9997600.0 -3530000.0 -1.98 8786240.0 -2590000.0 -1.46 9624040.0 -2380006.25 -1.39747983628843 -2.7945 -0.9871 3070361 PK04_103024 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B03 compound treatment 1.14676E7 -2060000.0 -1.16 1.03364E7 -1040000.0 -0.59 9840120.0 -2163926.25 -1.27060309257181 -1.7407 -0.9586 3189526 PK04_103025 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B04 compound treatment 1.21578E7 -1370000.0 -0.77 1.08414E7 -539000.0 -0.3 1.029316E7 -1710886.25 -1.00458939406488 -1.1992 -0.9217 3189527 PK04_103026 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B05 compound treatment 1.228908E7 -1240000.0 -0.7 1.054548E7 -835000.0 -0.47 1.05608E7 -1443246.25 -0.847437914574337 -1.1621 -0.9743 3070362 PK04_103027 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B06 compound treatment 1.291296E7 -614000.0 -0.34 1.14758E7 95300.0 0.05 1.147908E7 -524966.25 -0.308246984270293 -0.3461 -0.7432 3189528 PK04_103028 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B07 compound treatment 1.260568E7 -921000.0 -0.52 1.095728E7 -423000.0 -0.24 1.171724E7 -286806.25 -0.168405419648162 -0.5335 -0.8981 3070363 PK04_103029 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B08 compound treatment 1.323448E7 -293000.0 -0.16 1.167412E7 294000.0 0.17 1.180684E7 -197206.25 -0.115794552205506 -0.0663 -0.2546 3189529 PK04_103030 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3c5ccc(CO)cc5)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B09 compound treatment 1.207056E7 -1460000.0 -0.82 1.04006E7 -980000.0 -0.55 1.088716E7 -1116886.25 -0.65580752731334 -1.1694 -0.9871 3189530 PK04_103031 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B10 compound treatment 1.350452E7 -22500.0 -0.01 1.19632E7 583000.0 0.33 1.099472E7 -1009326.25 -0.592650999387759 -0.1601 -0.2363 3070364 PK04_103032 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4ccc(CN5CCCC5)cc4)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B11 compound treatment 1.245896E7 -1070000.0 -0.6 1.054068E7 -840000.0 -0.47 1.104352E7 -960526.25 -0.563996866227027 -0.9449 -0.9952 3189531 PK04_103033 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B12 compound treatment 1.355716E7 30200.0 0.02 1.165272E7 272000.0 0.15 1.254272E7 538673.75 0.316295683661702 0.2809 0.7982 3189532 PK04_103034 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B13 mock treatment 1.416084E7 634000.0 0.36 1.15806E7 200000.0 0.11 1.27318E7 727753.75 0.427318706162343 0.5173 0.9116 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B14 mock treatment 1.376024E7 233000.0 0.13 1.197568E7 595000.0 0.34 1.187432E7 -129726.25 -0.0761719926627553 0.2251 0.6121 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B15 compound treatment 1.243784E7 -1090000.0 -0.61 1.049236E7 -888000.0 -0.5 1.054272E7 -1461326.25 -0.858054036040444 -1.1372 -0.975 3070365 PK04_103035 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B16 compound treatment 1.339672E7 -130000.0 -0.07 1.1342E7 -38500.0 -0.02 1.130204E7 -702006.25 -0.412200421458327 -0.2927 -0.6983 3189533 PK04_103036 CC1C=C(CCCO)C/C(=N/P(=O)(Oc2ccccc2)Oc3ccccc3)/N1Cc4cccc(OC(F)(F)F)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B17 compound treatment 1.294296E7 -584000.0 -0.33 1.129596E7 -84500.0 -0.05 1.130128E7 -702766.25 -0.412646674351814 -0.4551 -0.8598 3070366 PK04_103037 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B18 compound treatment 1.300008E7 -527000.0 -0.3 1.060928E7 -771000.0 -0.43 1.099596E7 -1008086.25 -0.591922902561544 -0.7632 -0.9644 3189534 PK04_103038 CN1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B19 compound treatment 1.278168E7 -745000.0 -0.42 1.04532E7 -927000.0 -0.52 1.110924E7 -894806.25 -0.525407734437614 -0.8464 -0.9949 3189535 PK04_103039 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B20 compound treatment 1.249844E7 -1030000.0 -0.58 1.042568E7 -955000.0 -0.54 1.135812E7 -645926.25 -0.379271655317879 -0.8628 -0.9855 3070367 PK04_103040 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B21 compound treatment 1.293804E7 -589000.0 -0.33 1.084156E7 -539000.0 -0.3 1.124576E7 -758286.25 -0.445246622570746 -0.6232 -0.9857 3189536 PK04_103041 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B22 compound treatment 1.155436E7 -1970000.0 -1.11 1.009296E7 -1290000.0 -0.72 1.079648E7 -1207566.25 -0.709052543604636 -1.4675 -0.9771 3189537 PK04_103042 CN1C(=O)C2C(C3C(N(C)C2C=C3c4ccc(CO)cc4)c5cccs5)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B23 compound treatment 1.1633E7 -1890000.0 -1.06 1.019856E7 -1180000.0 -0.67 1.049888E7 -1505166.25 -0.883795781896315 -1.5086 -0.9829 3070368 PK04_103043 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 B24 compound treatment 1.048048E7 -3050000.0 -1.71 9333360.0 -2050000.0 -1.15 9464640.0 -2539406.25 -1.49107550894869 -2.5141 -0.9877 3189538 PK04_103044 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C01 compound treatment 1.169564E7 -1830000.0 -1.03 1.020008E7 -1180000.0 -0.66 1.091368E7 -1090366.25 -0.64023565003009 -1.3471 -0.9749 3070369 PK04_103045 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C02 compound treatment 1.182452E7 -1700000.0 -0.96 1.0324E7 -1060000.0 -0.59 1.050876E7 -1495286.25 -0.877994494280987 -1.4023 -0.9821 3189539 PK04_103046 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C03 compound treatment 1.213928E7 -1390000.0 -0.78 1.086196E7 -518000.0 -0.29 1.088172E7 -1122326.25 -0.65900175855093 -0.999 -0.941 3189540 PK04_103047 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C04 compound treatment 1.340668E7 -120000.0 -0.07 1.083344E7 -547000.0 -0.31 1.09764E7 -1027646.25 -0.603408042820231 -0.5652 -0.8302 3070370 PK04_103048 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C05 compound treatment 1.361332E7 86300.0 0.05 1.148448E7 104000.0 0.06 1.121492E7 -789126.25 -0.463355095248553 -0.2057 -0.4381 3189541 PK04_103049 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C06 compound treatment 1.34652E7 -61800.0 -0.03 1.128212E7 -98300.0 -0.06 1.154696E7 -457086.25 -0.268389554783603 -0.207 -0.7492 3189542 PK04_103050 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C07 compound treatment 1.43392E7 812000.0 0.46 1.153976E7 159000.0 0.09 1.17534E7 -250646.25 -0.147173176715947 0.2302 0.472 3070371 PK04_103051 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C08 compound treatment 1.374564E7 219000.0 0.12 1.135256E7 -27900.0 -0.02 1.196888E7 -35166.25 -0.0206487379152378 0.0499 0.3977 3189543 PK04_103052 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccc(CO)o3)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C09 compound treatment 1.380952E7 283000.0 0.16 1.113436E7 -246000.0 -0.14 1.219772E7 193673.75 0.113720357013082 0.0773 0.3229 3070372 PK04_103053 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C10 compound treatment 1.318664E7 -340000.0 -0.19 1.069544E7 -685000.0 -0.39 1.149096E7 -513086.25 -0.301271346935263 -0.5069 -0.9649 3189544 PK04_103054 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C11 mock treatment 1.349064E7 -36300.0 -0.02 1.15724E7 192000.0 0.11 1.25092E7 505153.75 0.296613582359494 0.2218 0.7013 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C12 mock treatment 1.386928E7 342000.0 0.19 1.141812E7 37700.0 0.02 1.277804E7 773993.75 0.454469671681856 0.3856 0.7808 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C13 compound treatment 1.36022E7 75200.0 0.04 1.199352E7 613000.0 0.35 1.264776E7 643713.75 0.377972530940459 0.4419 0.8604 3189545 PK04_103055 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C14 compound treatment 1.271308E7 -814000.0 -0.46 1.0226E7 -1150000.0 -0.65 1.05726E7 -1431446.25 -0.840509251228094 -1.1244 -0.9721 3189546 PK04_103056 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C15 mock treatment 1.328008E7 -247000.0 -0.14 1.101704E7 -363000.0 -0.2 1.187056E7 -133486.25 -0.0783797701357953 -0.2434 -0.9389 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C16 mock treatment 1.333552E7 -191000.0 -0.11 1.103968E7 -341000.0 -0.19 1.174396E7 -260086.25 -0.152716107392941 -0.261 -0.9749 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C17 compound treatment 1.317616E7 -351000.0 -0.2 1.095032E7 -430000.0 -0.24 1.161256E7 -391486.25 -0.229870883977372 -0.3863 -0.9964 3070427 PK04_103057 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C18 compound treatment 1.194136E7 -1590000.0 -0.89 1.047832E7 -902000.0 -0.51 1.070856E7 -1295486.25 -0.760676957282742 -1.2466 -0.9765 3189660 PK04_103058 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccccc3OCCO)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C19 compound treatment 1.302856E7 -498000.0 -0.28 1.081376E7 -567000.0 -0.32 1.17666E7 -237446.25 -0.139422468565913 -0.4263 -0.9543 3070428 PK04_103059 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C20 compound treatment 1.18142E7 -1710000.0 -0.96 9460040.0 -1920000.0 -1.08 1.0015E7 -1989046.25 -1.16791795308105 -1.8539 -0.9969 3189661 PK04_103060 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C21 compound treatment 1.244364E7 -1080000.0 -0.61 1.040264E7 -978000.0 -0.55 1.053984E7 -1464206.25 -0.859745099636815 -1.1655 -0.9807 3189662 PK04_103061 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C22 compound treatment 1.16296E7 -1900000.0 -1.07 1.014444E7 -1240000.0 -0.7 1.007812E7 -1925926.25 -1.13085547592725 -1.6699 -0.9808 3070429 PK04_103062 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C23 compound treatment 1.178628E7 -1740000.0 -0.98 1.071752E7 -663000.0 -0.37 1.070228E7 -1301766.25 -0.764364415402607 -1.2212 -0.9424 3189663 PK04_103063 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 C24 compound treatment 1.064292E7 -2880000.0 -1.62 9849360.0 -1530000.0 -0.86 9666800.0 -2337246.25 -1.3723722392812 -2.2252 -0.9711 3189664 PK04_103064 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3cccc(OCCO)c3)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D01 compound treatment 1.198632E7 -1540000.0 -0.87 1.043828E7 -942000.0 -0.53 1.106504E7 -939006.25 -0.551360863243032 -1.1242 -0.9732 3070430 PK04_103065 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D02 compound treatment 686560.0 -1.28E7 -7.21 5877160.0 -5500000.0 -3.1 7095560.0 -4908486.25 -2.88213972592467 -7.6165 -0.9109 3189665 PK04_103066 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5ccc(CN6CCCC6)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D03 compound treatment 1.234652E7 -1180000.0 -0.66 1.096344E7 -417000.0 -0.23 1.15052E7 -498846.25 -0.292909976930983 -0.6875 -0.9023 3070431 PK04_103067 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D04 compound treatment 1.26366E7 -890000.0 -0.5 1.053684E7 -844000.0 -0.47 1.034124E7 -1662806.25 -0.976358026803238 -1.1266 -0.9425 3189666 PK04_103068 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D05 compound treatment 1.23204E7 -1210000.0 -0.68 1.090504E7 -475000.0 -0.27 1.132704E7 -677006.25 -0.397521049962051 -0.7753 -0.9341 3189667 PK04_103069 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D06 compound treatment 1.267624E7 -851000.0 -0.48 1.068632E7 -694000.0 -0.39 1.073952E7 -1264526.25 -0.742498023621753 -0.9302 -0.9633 3189668 PK04_103070 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D07 compound treatment 1.280336E7 -724000.0 -0.41 1.156732E7 187000.0 0.11 1.138364E7 -620406.25 -0.36428695289448 -0.3843 -0.6913 3070432 PK04_103071 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D08 compound treatment 1.344752E7 -79500.0 -0.04 1.12562E7 -124000.0 -0.07 1.223732E7 233273.75 0.136972481463184 0.0129 0.0807 3189669 PK04_103072 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D09 compound treatment 1.325008E7 -277000.0 -0.16 1.176676E7 386000.0 0.22 1.1981E7 -23046.25 -0.0135321786138428 0.0279 0.1044 3070433 PK04_103073 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D10 compound treatment 1.373492E7 208000.0 0.12 1.20464E7 666000.0 0.37 1.204764E7 43593.75 0.0255971540466327 0.2986 0.759 3189670 PK04_103074 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D11 mock treatment 1.45592E7 1030000.0 0.58 1.135092E7 -29500.0 -0.02 1.235696E7 352913.75 0.207222081695767 0.4448 0.7221 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D12 mock treatment 1.448244E7 955000.0 0.54 1.233692E7 956000.0 0.54 1.235444E7 350393.75 0.205742401048942 0.7395 0.939 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D13 compound treatment 1.448808E7 961000.0 0.54 1.187916E7 499000.0 0.28 1.230964E7 305593.75 0.179436967327614 0.5773 0.9101 3189671 PK04_103075 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D14 compound treatment 1.351796E7 -9030.0 -0.01 1.221608E7 836000.0 0.47 1.181616E7 -187886.25 -0.110322082511694 0.205 0.4242 3070434 PK04_103076 NC(=O)N1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D15 mock treatment 1.349396E7 -33000.0 -0.02 1.140044E7 20000.0 0.01 1.239888E7 394833.75 0.231836451820724 0.1296 0.5567 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D16 mock treatment 1.356744E7 40500.0 0.02 1.16528E7 272000.0 0.15 1.155584E7 -448206.25 -0.263175442028125 -0.0503 -0.1647 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D17 compound treatment 1.270004E7 -827000.0 -0.46 1.121156E7 -169000.0 -0.1 1.168268E7 -321366.25 -0.188698182804615 -0.432 -0.8466 3189672 PK04_103077 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D18 compound treatment 1.228536E7 -1240000.0 -0.7 1.163192E7 251000.0 0.14 1.102716E7 -976886.25 -0.57360304693419 -0.6521 -0.7134 3189673 PK04_103078 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D19 compound treatment 1.250568E7 -1020000.0 -0.57 1.097748E7 -403000.0 -0.23 1.151908E7 -484966.25 -0.28475998987625 -0.6266 -0.9222 3070435 PK04_103079 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D20 compound treatment 1.210212E7 -1420000.0 -0.8 1.054836E7 -832000.0 -0.47 1.0905E7 -1099046.25 -0.645332327813597 -1.1051 -0.9781 3189674 PK04_103080 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)CC2)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D21 compound treatment 1.246432E7 -1060000.0 -0.6 1.062908E7 -751000.0 -0.42 1.143152E7 -572526.25 -0.33617302060481 -0.7829 -0.9724 3189675 PK04_103081 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D22 compound treatment 1.221456E7 -1310000.0 -0.74 1.029672E7 -1080000.0 -0.61 1.14604E7 -543646.25 -0.319215410652311 -0.9621 -0.9538 3070436 PK04_103082 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D23 compound treatment 1.19644E7 -1560000.0 -0.88 1.06896E7 -691000.0 -0.39 1.08628E7 -1141246.25 -0.670111106899313 -1.1181 -0.9551 3189676 PK04_103083 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 D24 compound treatment 1.232568E7 -1200000.0 -0.67 1.055664E7 -824000.0 -0.46 1.118848E7 -815566.25 -0.478879998543015 -0.9338 -0.9845 3070437 PK04_103084 CN1CCC(=CC1C2CC2)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E01 mock treatment 1.23258E7 -1200000.0 -0.67 1.13804E7 -56.5 0.0 1.09692E7 -1034846.25 -0.607635701811158 -0.7404 -0.8154 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E02 mock treatment 1.366404E7 137000.0 0.08 1.160588E7 225000.0 0.13 1.183708E7 -166966.25 -0.0980383844436092 0.0611 0.3435 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E03 compound treatment 1.31338E7 -393000.0 -0.22 1.059792E7 -783000.0 -0.44 1.119884E7 -805206.25 -0.472796866994958 -0.6548 -0.9589 3189677 PK04_103085 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E04 compound treatment 1.270056E7 -826000.0 -0.46 1.14484E7 67900.0 0.04 1.121024E7 -793806.25 -0.466103073592656 -0.515 -0.7816 3070438 PK04_103086 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E05 compound treatment 1.379972E7 273000.0 0.15 1.120324E7 -177000.0 -0.1 1.142704E7 -577006.25 -0.338803563976943 -0.1648 -0.428 3189678 PK04_103087 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E06 compound treatment 1.293284E7 -594000.0 -0.33 1.12364E7 -144000.0 -0.08 1.22514E7 247353.75 0.145239903489887 -0.1556 -0.4174 3189679 PK04_103088 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E07 compound treatment 1.381468E7 288000.0 0.16 1.14404E7 59900.0 0.03 1.276496E7 760913.75 0.446789424515004 0.3707 0.7783 3189680 PK04_103089 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E08 compound treatment 1.30348E7 -492000.0 -0.28 1.124212E7 -138000.0 -0.08 1.249292E7 488873.75 0.287054375641119 -0.0388 -0.0956 3070490 PK04_103090 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E09 mock treatment 1.352408E7 -2910.0 0.0 1.201068E7 630000.0 0.35 1.223776E7 233713.75 0.137230838401519 0.2831 0.7443 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E10 mock treatment 1.378396E7 257000.0 0.14 1.172928E7 349000.0 0.2 1.260008E7 596033.75 0.349976033622759 0.3988 0.935 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E11 compound treatment 1.055516E7 -2970000.0 -1.67 8291280.0 -3090000.0 -1.74 9082760.0 -2921286.25 -1.71530584442862 -2.958 -0.9999 3187704 PK04_103091 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E12 compound treatment 1.268696E7 -840000.0 -0.47 1.047004E7 -910000.0 -0.51 1.166492E7 -339126.25 -0.19912640831557 -0.6833 -0.9431 3070491 PK04_103092 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E13 compound treatment 1.1634E7 -1890000.0 -1.06 8669440.0 -2710000.0 -1.53 9461480.0 -2542566.25 -1.49293098150582 -2.3569 -0.9882 3187705 PK04_103093 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E14 compound treatment 1.214536E7 -1380000.0 -0.78 1.059592E7 -785000.0 -0.44 1.132948E7 -674566.25 -0.396088343304014 -0.9317 -0.9538 3187706 PK04_103094 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E15 compound treatment 1.256576E7 -961000.0 -0.54 1.091844E7 -462000.0 -0.26 1.182452E7 -179526.25 -0.105413300683339 -0.5227 -0.8591 3070492 PK04_103095 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E16 compound treatment 1.27674E7 -760000.0 -0.43 1.08666E7 -514000.0 -0.29 1.189432E7 -109726.25 -0.0644284954657338 -0.4505 -0.8673 3187707 PK04_103096 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E17 mock treatment 1.393448E7 407000.0 0.23 1.084476E7 -536000.0 -0.3 1.166128E7 -342766.25 -0.201263724805428 -0.1582 -0.3689 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E18 mock treatment 1.366496E7 138000.0 0.08 1.103132E7 -349000.0 -0.2 1.142404E7 -580006.25 -0.340565088556496 -0.2654 -0.6621 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E19 compound treatment 1.0655E7 -2870000.0 -1.61 8915080.0 -2470000.0 -1.39 1.17112E7 -292846.25 -0.171951955801662 -1.8319 -0.8581 3070493 PK04_103097 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E20 compound treatment 1.188968E7 -1640000.0 -0.92 1.048036E7 -900000.0 -0.51 1.126272E7 -741326.25 -0.435288136947672 -1.0748 -0.9456 3187708 PK04_103098 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E21 compound treatment 1.201784E7 -1510000.0 -0.85 8685760.0 -2690000.0 -1.52 1.025604E7 -1748006.25 -1.02638532486255 -1.9577 -0.9701 3187709 PK04_103099 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E22 compound treatment 1.2344E7 -1180000.0 -0.66 1.032304E7 -1060000.0 -0.6 1.102452E7 -979526.25 -0.575153188564197 -1.0593 -0.998 3070494 PK04_103100 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E23 compound treatment 1.12154E7 -2310000.0 -1.3 9924040.0 -1460000.0 -0.82 1.063176E7 -1372286.25 -0.805771986519305 -1.6882 -0.9735 3187710 PK04_103101 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 E24 compound treatment 1.147168E7 -2060000.0 -1.15 1.017068E7 -1210000.0 -0.68 1.071492E7 -1289126.25 -0.756942525174089 -1.4967 -0.9723 3187711 PK04_103102 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F01 mock treatment 1.220744E7 -1320000.0 -0.74 1.13346E7 -45900.0 -0.03 1.143184E7 -572206.25 -0.335985124649658 -0.6368 -0.7821 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F02 mock treatment 1.314908E7 -378000.0 -0.21 1.138084E7 383.0 0.0 1.212624E7 122193.75 0.0717490980309271 -0.081 -0.3615 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F03 compound treatment 1.328768E7 -239000.0 -0.13 1.135416E7 -26300.0 -0.01 1.162376E7 -380286.25 -0.22329452554704 -0.2151 -0.8239 3070495 PK04_103103 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F04 compound treatment 1.3489E7 -38000.0 -0.02 1.196016E7 580000.0 0.33 1.11044E7 -899646.25 -0.528249660759293 -0.1289 -0.2075 3187712 PK04_103104 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4ccc(CN5CCCC5)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F05 compound treatment 1.241996E7 -1110000.0 -0.62 1.01662E7 -1210000.0 -0.68 9032840.0 -2971206.25 -1.74461761343238 -1.7609 -0.8919 3070496 PK04_103105 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F06 compound treatment 1.369596E7 169000.0 0.09 1.260748E7 1230000.0 0.69 1.176812E7 -235926.25 -0.138529962778939 0.3736 0.5256 3187713 PK04_103106 CN1C(C2CC2)C3C4C(C1C=C3c5ccc(CO)cc5)C(=O)N(C(=O)N)C4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F07 compound treatment 1.257544E7 -952000.0 -0.53 1.021628E7 -1160000.0 -0.66 9926120.0 -2077926.25 -1.22010605462462 -1.3914 -0.9373 3070497 PK04_103107 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F08 compound treatment 1.386788E7 341000.0 0.19 1.179588E7 415000.0 0.23 1.209348E7 89433.75 0.0525132496222059 0.2759 0.8993 3187714 PK04_103108 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F09 mock treatment 1.374848E7 221000.0 0.12 1.166288E7 282000.0 0.16 1.200088E7 -3166.25 -0.00185914240000346 0.1625 0.8051 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F10 mock treatment 1.42656E7 739000.0 0.41 1.208712E7 707000.0 0.4 1.224132E7 237273.75 0.139321180902589 0.5496 0.9294 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F11 compound treatment 1.237064E7 -1160000.0 -0.65 1.098056E7 -400000.0 -0.23 1.102088E7 -983166.25 -0.577290505054055 -0.8383 -0.9338 3187715 PK04_103109 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F12 compound treatment 1.42786E7 752000.0 0.42 1.154468E7 164000.0 0.09 1.18152E7 -188846.25 -0.110885770377151 0.2331 0.5224 3070498 PK04_103110 CC1C=C(CCCO)CCN1Cc2cccc(OC(F)(F)F)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F13 compound treatment 1.188188E7 -1650000.0 -0.92 1.097064E7 -410000.0 -0.23 1.104236E7 -961686.25 -0.564677989064454 -0.9927 -0.8966 3187716 PK04_103111 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F14 compound treatment 1.336468E7 -162000.0 -0.09 1.109936E7 -281000.0 -0.16 1.195216E7 -51886.25 -0.0304663015719477 -0.1616 -0.8727 3070499 PK04_103112 CN1CCC(=CC1c2cccs2)c3ccc(CO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F15 compound treatment 1.279072E7 -736000.0 -0.41 1.063216E7 -748000.0 -0.42 1.149024E7 -513806.25 -0.301694112834355 -0.6561 -0.9898 3187717 PK04_103113 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F16 compound treatment 1.393724E7 410000.0 0.23 1.163764E7 257000.0 0.14 1.219184E7 187793.75 0.110267768837157 0.2803 0.9546 3187718 PK04_103114 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F17 mock treatment 1.372892E7 202000.0 0.11 1.155432E7 174000.0 0.1 1.213636E7 132313.75 0.0776913076126199 0.1668 0.9887 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F18 mock treatment 1.404812E7 521000.0 0.29 1.143104E7 50600.0 0.03 1.177224E7 -231806.25 -0.136110802356353 0.1069 0.3297 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F19 compound treatment 1.132732E7 -2200000.0 -1.24 9902440.0 -1480000.0 -0.83 1.035856E7 -1645486.25 -0.966188158230618 -1.7515 -0.9865 3070500 PK04_103115 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F20 compound treatment 1.262304E7 -904000.0 -0.51 1.100832E7 -372000.0 -0.21 1.192264E7 -81406.25 -0.0477997034347514 -0.4417 -0.8011 3187719 PK04_103116 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)CC1)c4ccc(CN5CCCC5)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F21 compound treatment 1.119208E7 -2330000.0 -1.31 1.0496E7 -884000.0 -0.5 1.096272E7 -1041326.25 -0.611440594902993 -1.3976 -0.9133 3070501 PK04_103117 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F22 compound treatment 1.209912E7 -1430000.0 -0.8 1.047504E7 -905000.0 -0.51 1.098196E7 -1022086.25 -0.600143350599459 -1.1038 -0.9821 3187720 PK04_103118 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)CC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F23 compound treatment 1.137832E7 -2150000.0 -1.21 1.07002E7 -680000.0 -0.38 1.063372E7 -1370326.25 -0.804621123793996 -1.3824 -0.9215 3187721 PK04_103119 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 F24 compound treatment 1.12608E7 -2270000.0 -1.27 8698920.0 -2680000.0 -1.51 1.040264E7 -1601406.25 -0.940305490408382 -2.1493 -0.9828 3070502 PK04_103120 CN1C(C2C3C(C1C=C2c4ccc(CO)cc4)C(=O)N(C(=O)N)C3=O)c5cccs5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G01 compound treatment 8517840.0 -5010000.0 -2.81 7581840.0 -3800000.0 -2.14 7323760.0 -4680286.25 -2.74814642290665 -4.4456 -0.9931 3187722 PK04_103121 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G02 compound treatment 1.206888E7 -1460000.0 -0.82 1.12178E7 -163000.0 -0.09 1.098124E7 -1022806.25 -0.600566116498552 -0.8724 -0.8556 3187723 PK04_103122 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G03 mock treatment 1.304504E7 -482000.0 -0.27 1.146696E7 86500.0 0.05 1.201512E7 11073.75 0.00650222760427582 -0.1244 -0.4522 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G04 mock treatment 1.3882E7 355000.0 0.2 1.145956E7 79100.0 0.04 1.215724E7 153193.75 0.0899515186863103 0.1928 0.8635 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G05 compound treatment 1.183524E7 -1690000.0 -0.95 1.003616E7 -1340000.0 -0.76 8454280.0 -3549766.25 -2.08433350034782 -2.1889 -0.9073 3070503 PK04_103123 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G06 compound treatment 1.279584E7 -731000.0 -0.41 1.162768E7 247000.0 0.14 1.16204E7 -383646.25 -0.22526743307614 -0.2868 -0.587 3187724 PK04_103124 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G07 compound treatment 1.071824E7 -2810000.0 -1.58 7689720.0 -3690000.0 -2.08 8531400.0 -3472646.25 -2.0390505751561 -3.2876 -0.9929 3070504 PK04_103125 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G08 compound treatment 1.244468E7 -1080000.0 -0.61 1.031684E7 -1060000.0 -0.6 1.081076E7 -1193286.25 -0.700667686605962 -1.1012 -0.9974 3187725 PK04_103126 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G09 compound treatment 1.342096E7 -106000.0 -0.06 1.18914E7 511000.0 0.29 1.20608E7 56753.75 0.0333243752022728 0.1509 0.5105 3187726 PK04_103127 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G10 compound treatment 1.133164E7 -2200000.0 -1.23 1.076736E7 -613000.0 -0.35 1.173344E7 -270606.25 -0.158893186918574 -1.0029 -0.7773 3070543 PK04_103128 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G11 compound treatment 1.405208E7 525000.0 0.29 1.175848E7 378000.0 0.21 1.081368E7 -1190366.25 -0.698953136015197 -0.1104 -0.1401 3187727 PK04_103129 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G12 compound treatment 1.377756E7 251000.0 0.14 1.27066E7 1330000.0 0.75 1.210216E7 98113.75 0.0576099274057132 0.5455 0.716 3187844 PK04_103130 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G13 compound treatment 1.429996E7 773000.0 0.43 1.177212E7 392000.0 0.22 1.261264E7 608593.75 0.357350949862489 0.5843 0.9673 3070544 PK04_103131 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G14 compound treatment 1.287824E7 -649000.0 -0.36 1.084612E7 -534000.0 -0.3 1.193868E7 -65366.25 -0.0383814186827402 -0.4062 -0.8569 3187845 PK04_103132 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G15 compound treatment 9445560.0 -4080000.0 -2.29 1.151804E7 138000.0 0.08 1.244736E7 443313.75 0.260302689026304 -1.1286 -0.4889 3070545 PK04_103133 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G16 compound treatment 1.347212E7 -54900.0 -0.03 1.148904E7 109000.0 0.06 1.27048E7 700753.75 0.411464984946364 0.2551 0.6115 3187846 PK04_103134 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G17 compound treatment 1.268784E7 -839000.0 -0.47 1.111764E7 -263000.0 -0.15 1.203692E7 32873.75 0.0193026395490292 -0.3464 -0.7007 3070546 PK04_103135 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G18 compound treatment 1.30754E7 -452000.0 -0.25 1.094348E7 -437000.0 -0.25 1.211392E7 109873.75 0.0645151037575618 -0.2512 -0.6994 3187847 PK04_103136 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G19 mock treatment 1.385344E7 326000.0 0.18 1.149324E7 113000.0 0.06 1.209708E7 93033.75 0.0546270791176698 0.1741 0.8634 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G20 mock treatment 1.348516E7 -41800.0 -0.02 1.147272E7 92300.0 0.05 1.317332E7 1169273.75 0.686568150283789 0.4128 0.5992 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G21 compound treatment 1.276404E7 -763000.0 -0.43 1.110604E7 -274000.0 -0.15 1.25078E7 503753.75 0.295791537555702 -0.1658 -0.3053 3070547 PK04_103137 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G22 compound treatment 1.282648E7 -701000.0 -0.39 1.045888E7 -922000.0 -0.52 1.144456E7 -559486.25 -0.328516260432352 -0.7163 -0.9823 3187848 PK04_103138 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G23 compound treatment 1.235836E7 -1170000.0 -0.66 1.021348E7 -1170000.0 -0.66 1.131124E7 -692806.25 -0.406798412747697 -0.9931 -0.9795 3070548 PK04_103139 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 G24 compound treatment 1.14766E7 -2050000.0 -1.15 9229040.0 -2150000.0 -1.21 1.103876E7 -965286.25 -0.566791818559918 -1.6914 -0.9584 3187849 PK04_103140 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H01 compound treatment 1021600.0 -1.25E7 -7.02 719800.0 -1.07E7 -6.0 842600.0 -1.116144625E7 -6.55372063757903 -11.3038 -0.998 3070549 PK04_103141 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H02 compound treatment 1.264748E7 -880000.0 -0.49 1.094792E7 -433000.0 -0.24 1.143892E7 -565126.25 -0.331827926641912 -0.6174 -0.9602 3187850 PK04_103142 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H03 mock treatment 1.323792E7 -289000.0 -0.16 1.114408E7 -236000.0 -0.13 1.172504E7 -279006.25 -0.163825455741323 -0.2651 -0.9957 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H04 mock treatment 1.323904E7 -288000.0 -0.16 1.194304E7 563000.0 0.32 1.167336E7 -330686.25 -0.194170652498427 -0.0226 -0.0559 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H05 compound treatment 1.344964E7 -77300.0 -0.04 1.138344E7 2980.0 0.0 1.194416E7 -59886.25 -0.0351637004507563 -0.0444 -0.7943 3187851 PK04_103143 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H06 compound treatment 1.479312E7 1270000.0 0.71 1.151892E7 138000.0 0.08 1.145896E7 -545086.25 -0.320060942450497 0.2708 0.3455 3187852 PK04_103144 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4ccc(CN5CCCC5)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H07 compound treatment 1.368684E7 160000.0 0.09 1.221852E7 838000.0 0.47 1.198484E7 -19206.25 -0.0112774271520147 0.3177 0.6614 3070550 PK04_103145 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H08 compound treatment 1.36418E7 115000.0 0.06 1.108952E7 -291000.0 -0.16 1.234284E7 338793.75 0.198931172674669 0.0575 0.2166 3187853 PK04_103146 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C(=O)N)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H09 compound treatment 1.381504E7 288000.0 0.16 1.112268E7 -258000.0 -0.15 1.191872E7 -85326.25 -0.0501014288853676 -0.0193 -0.0865 3070551 PK04_103147 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H10 compound treatment 1.388484E7 358000.0 0.2 1.203908E7 659000.0 0.37 1.237084E7 366793.75 0.2153720687505 0.4544 0.9597 3070552 PK04_103148 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H11 compound treatment 1.342864E7 -98300.0 -0.06 1.133832E7 -42100.0 -0.02 1.245092E7 446873.75 0.262393031527373 0.1059 0.3934 3187854 PK04_103149 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H12 compound treatment 1.346888E7 -58100.0 -0.03 1.280724E7 1430000.0 0.8 1.298552E7 981473.75 0.576296711603757 0.7776 0.7862 3070553 PK04_103150 CN1CCC(=CC1c2cccs2)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H13 compound treatment 1.460612E7 1080000.0 0.61 1.12068E7 -174000.0 -0.1 1.241072E7 406673.75 0.23878860216136 0.4314 0.6548 3187855 PK04_103151 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H14 compound treatment 1.74582E7 3930000.0 2.21 1.106096E7 -319000.0 -0.18 1.260652E7 602473.75 0.3537574397202 1.3752 0.613 3187856 PK04_103152 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H15 compound treatment 1.328496E7 -242000.0 -0.14 1.184972E7 469000.0 0.26 1.206576E7 61713.75 0.0362367625071342 0.0949 0.3172 3070554 PK04_103153 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H16 compound treatment 1.37476E7 221000.0 0.12 1.129624E7 -84200.0 -0.05 1.241308E7 409033.75 0.240174334830609 0.1828 0.6664 3187857 PK04_103154 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H17 compound treatment 1.37446E7 218000.0 0.12 1.166332E7 283000.0 0.16 1.202208E7 18033.75 0.0105889646288393 0.1686 0.8388 3187858 PK04_103155 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H18 compound treatment 1.208632E7 -1440000.0 -0.81 1.127076E7 -110000.0 -0.06 1.10684E7 -935646.25 -0.549387955713932 -0.82 -0.8367 3070555 PK04_103156 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)CC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H19 mock treatment 1.3443E7 -84000.0 -0.05 1.043E7 -950000.0 -0.54 1.155416E7 -449886.25 -0.264161895792675 -0.4886 -0.8164 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H20 mock treatment 1.380996E7 283000.0 0.16 1.105112E7 -329000.0 -0.19 1.243712E7 433073.75 0.254290018461429 0.1315 0.3731 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H21 compound treatment 1.274112E7 -786000.0 -0.44 1.1031E7 -349000.0 -0.2 1.159304E7 -411006.25 -0.241332537241665 -0.5078 -0.94 3187859 PK04_103157 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H22 compound treatment 1.271844E7 -809000.0 -0.45 1.077232E7 -608000.0 -0.34 1.115312E7 -850926.25 -0.499642501587349 -0.7483 -0.9885 3070556 PK04_103158 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H23 compound treatment 1.285248E7 -675000.0 -0.38 1.110032E7 -280000.0 -0.16 1.11492E7 -854846.25 -0.501944227037965 -0.5996 -0.9248 3187860 PK04_103159 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 H24 compound treatment 1.129928E7 -2230000.0 -1.25 9586600.0 -1790000.0 -1.01 1.060156E7 -1402486.25 -0.823504667286807 -1.7809 -0.9858 3070597 PK04_103160 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I01 compound treatment 1.173648E7 -1790000.0 -1.01 1.0535E7 -845000.0 -0.48 1.111436E7 -889686.25 -0.522401399155177 -1.157 -0.9413 3187861 PK04_103161 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I02 compound treatment 1.250184E7 -1030000.0 -0.58 1.061776E7 -763000.0 -0.43 1.107636E7 -927686.25 -0.544714043829517 -0.8948 -0.9926 3187862 PK04_103162 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I03 compound treatment 1.277616E7 -751000.0 -0.42 1.069036E7 -690000.0 -0.39 1.149812E7 -505926.25 -0.297067174938729 -0.6393 -0.99 3070598 PK04_103163 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I04 compound treatment 1.377932E7 252000.0 0.14 1.076088E7 -620000.0 -0.35 1.233368E7 329633.75 0.193552650958434 -0.0078 -0.0184 3187863 PK04_103164 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I05 mock treatment 1.263772E7 -889000.0 -0.5 1.08008E7 -580000.0 -0.33 1.2255E7 250953.75 0.147353732985351 -0.3917 -0.6374 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I06 mock treatment 1.564184E7 2110000.0 1.19 1.148892E7 108000.0 0.06 1.193496E7 -69086.25 -0.0405657091613862 0.6976 0.5862 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I07 compound treatment 1.297552E7 -551000.0 -0.31 1.234612E7 966000.0 0.54 1.125416E7 -749886.25 -0.440314353747997 -0.1192 -0.1558 3070599 PK04_103165 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I08 compound treatment 1.380592E7 279000.0 0.16 1.238556E7 1010000.0 0.57 1.182508E7 -178966.25 -0.105084482761822 0.3564 0.5976 3187864 PK04_103166 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I09 compound treatment 1.323008E7 -297000.0 -0.17 1.177512E7 395000.0 0.22 1.186048E7 -143566.25 -0.0842984927230941 -0.0167 -0.0575 3187865 PK04_103167 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I10 compound treatment 1.362692E7 99900.0 0.06 1.087904E7 -501000.0 -0.28 1.207352E7 69473.75 0.0407932394195785 -0.107 -0.3681 3070600 PK04_103168 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I11 compound treatment 1.303368E7 -493000.0 -0.28 1.132868E7 -51800.0 -0.03 1.19188E7 -85246.25 -0.0500544548965795 -0.2057 -0.7267 3187866 PK04_103169 COCC(=C=CC[C@H](O)c1ccccc1OCCO)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I12 compound treatment 1.357304E7 46100.0 0.03 1.221944E7 839000.0 0.47 1.192816E7 -75886.25 -0.0445584982083735 0.2619 0.5512 3187978 PK04_103170 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I13 compound treatment 1.392432E7 397000.0 0.22 1.092912E7 -451000.0 -0.25 1.263888E7 634833.75 0.372758418184981 0.1974 0.3922 3070601 PK04_103171 CCCCC(=C=CC[C@H](O)c1ccc(CO)o1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I14 compound treatment 1.299836E7 -529000.0 -0.3 1.087432E7 -506000.0 -0.28 1.122896E7 -775086.25 -0.455111160216244 -0.5987 -0.9757 3187979 PK04_103172 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I15 compound treatment 1.357392E7 46900.0 0.03 1.138504E7 4580.0 0.0 1.172592E7 -278126.25 -0.163308741864654 -0.0776 -0.4689 3070602 PK04_103173 CC(C)C(=C=CC[C@H](O)c1ccc(CO)o1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I16 compound treatment 1.348852E7 -38500.0 -0.02 1.090288E7 -478000.0 -0.27 1.15458E7 -458246.25 -0.26907067762103 -0.323 -0.8479 3187980 PK04_103174 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I17 compound treatment 1.327984E7 -247000.0 -0.14 1.250848E7 1130000.0 0.63 1.21748E7 170753.75 0.100262309225295 0.3443 0.5236 3070603 PK04_103175 COCC(=C=CC[C@H](O)c1ccc(CO)o1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I18 compound treatment 1.321544E7 -312000.0 -0.17 1.15188E7 138000.0 0.08 1.202176E7 17713.75 0.0104010686736869 -0.0501 -0.261 3187981 PK04_103176 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I19 compound treatment 1.257856E7 -948000.0 -0.53 1.163844E7 258000.0 0.15 1.151884E7 -485206.25 -0.284900911842615 -0.3882 -0.6248 3070604 PK04_103177 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I20 compound treatment 1.085156E7 -2680000.0 -1.5 1.081452E7 -566000.0 -0.32 1.154632E7 -457726.25 -0.268765346693907 -1.2067 -0.7738 3187982 PK04_103178 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I21 mock treatment 1.29338E7 -593000.0 -0.33 1.117688E7 -204000.0 -0.11 1.152752E7 -476526.25 -0.279804234059107 -0.4201 -0.9336 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I22 mock treatment 1.238288E7 -1140000.0 -0.64 1.062032E7 -760000.0 -0.43 1.126476E7 -739286.25 -0.434090300233575 -0.8687 -0.9808 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I23 compound treatment 1.213956E7 -1390000.0 -0.78 9864680.0 -1520000.0 -0.85 1.063664E7 -1367406.25 -0.802906573203231 -1.4061 -0.9993 3187983 PK04_103179 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 I24 compound treatment 1.12866E7 -2240000.0 -1.26 1.110452E7 -276000.0 -0.16 1.048996E7 -1514086.25 -0.889033381646187 -1.3295 -0.8585 3070605 PK04_103180 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J01 compound treatment 1.170204E7 -1820000.0 -1.03 1.03624E7 -1020000.0 -0.57 1.093104E7 -1073006.25 -0.630042294463075 -1.2864 -0.9653 3187984 PK04_103181 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J02 compound treatment 1.183116E7 -1700000.0 -0.95 1.004632E7 -1330000.0 -0.75 1.035952E7 -1644526.25 -0.965624470365161 -1.541 -0.994 3187985 PK04_103182 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J03 compound treatment 1.288176E7 -645000.0 -0.36 1.061468E7 -766000.0 -0.43 1.081528E7 -1188766.25 -0.698013656239436 -0.8611 -0.9601 3070606 PK04_103183 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J04 compound treatment 1.182764E7 -1700000.0 -0.95 9843040.0 -1540000.0 -0.87 1.016856E7 -1835486.25 -1.07775138160232 -1.673 -0.996 3187986 PK04_103184 CN1CCC(=CC1c2ccc(CN3CCCC3)cc2)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J05 mock treatment 1.319892E7 -328000.0 -0.18 1.144952E7 69100.0 0.04 1.162892E7 -375126.25 -0.220264703270209 -0.2111 -0.7285 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J06 mock treatment 1.38698E7 343000.0 0.19 1.10284E7 -352000.0 -0.2 1.218448E7 180433.75 0.105946161868654 0.0579 0.1957 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J07 compound treatment 1.274508E7 -782000.0 -0.44 1.016332E7 -1220000.0 -0.69 9667240.0 -2336806.25 -1.37211388234286 -1.4413 -0.9035 3187987 PK04_103185 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J08 compound treatment 1.290184E7 -625000.0 -0.35 1.074488E7 -636000.0 -0.36 1.119928E7 -804766.25 -0.472538510056624 -0.6821 -0.9901 3070607 PK04_103186 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3ccc(CN4CCCC4)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J09 compound treatment 1.328512E7 -242000.0 -0.14 1.149964E7 119000.0 0.07 1.174788E7 -256166.25 -0.150414381942325 -0.1265 -0.5927 3187988 PK04_103187 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J10 compound treatment 1.592108E7 2390000.0 1.34 1.077652E7 -604000.0 -0.34 1.152468E7 -479366.25 -0.281471810661084 0.4176 0.2951 3070608 PK04_103188 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J11 compound treatment 1.418728E7 660000.0 0.37 1.13984E7 17900.0 0.01 1.191776E7 -86286.25 -0.0506651167508246 0.1907 0.5093 3187989 PK04_103189 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J12 compound treatment 1.346076E7 -66200.0 -0.04 1.1866E7 486000.0 0.27 1.34368E7 1432753.75 0.841276982357349 0.622 0.7026 3070609 PK04_103190 CN1CCC(=CC1C2CC2)c3ccc(CO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J13 compound treatment 1.345808E7 -68900.0 -0.04 1.280956E7 1430000.0 0.8 1.337476E7 1370713.75 0.804848654052189 0.9068 0.7964 3187990 PK04_103191 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J14 compound treatment 1.336512E7 -162000.0 -0.09 1.15006E7 120000.0 0.07 1.30462E7 1042153.75 0.61192648209952 0.3399 0.5461 3187991 PK04_103192 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J15 compound treatment 1.101716E7 -2510000.0 -1.41 8887960.0 -2490000.0 -1.4 8746280.0 -3257766.25 -1.91287844127131 -2.7284 -0.9887 3070610 PK04_103193 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J16 compound treatment 1.425524E7 728000.0 0.41 1.089952E7 -481000.0 -0.27 1.199696E7 -7086.25 -0.00416086785061967 0.0775 0.1579 3187992 PK04_103194 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J17 compound treatment 1.09698E7 -2560000.0 -1.44 1.028676E7 -1090000.0 -0.62 9230240.0 -2773806.25 -1.62870929609778 -2.125 -0.9415 3070654 PK04_103195 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J18 compound treatment 1.329496E7 -232000.0 -0.13 1.116496E7 -215000.0 -0.12 1.133428E7 -669766.25 -0.393269903976729 -0.3723 -0.8625 3187993 PK04_103196 CN1C(C2CC2)C3C4C(C1C=C3CCCO)C(=O)N(C(=O)N)C4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J19 compound treatment 1.359268E7 65700.0 0.04 1.080948E7 -571000.0 -0.32 1.112524E7 -878806.25 -0.516012936679997 -0.4622 -0.7589 3070655 PK04_103197 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J20 compound treatment 1.290068E7 -626000.0 -0.35 1.064332E7 -737000.0 -0.41 1.073468E7 -1269366.25 -0.745339949943432 -0.873 -0.9461 3187994 PK04_103198 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C3CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J21 mock treatment 1.328732E7 -240000.0 -0.13 1.07654E7 -615000.0 -0.35 1.190144E7 -102606.25 -0.0602478104635942 -0.3124 -0.8301 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J22 mock treatment 1.330536E7 -222000.0 -0.12 1.08378E7 -543000.0 -0.31 1.178004E7 -224006.25 -0.131530838449514 -0.3242 -0.9129 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J23 compound treatment 9168320.0 -4360000.0 -2.45 9628040.0 -1750000.0 -0.99 7668440.0 -4335606.25 -2.54575899221319 -3.4528 -0.9416 3187995 PK04_103199 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 J24 compound treatment 1.178892E7 -1740000.0 -0.98 9502960.0 -1880000.0 -1.06 1.071204E7 -1292006.25 -0.75863358877046 -1.6118 -0.991 3070656 PK04_103200 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)CCCO)C(=O)OCCS(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K01 compound treatment 1.059892E7 -2930000.0 -1.64 1.021092E7 -1170000.0 -0.66 1.035788E7 -1646166.25 -0.966587437135316 -1.8877 -0.9354 3187996 PK04_103201 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K02 compound treatment 1.103824E7 -2490000.0 -1.4 9157720.0 -2220000.0 -1.25 9512800.0 -2491246.25 -1.46279716769826 -2.374 -0.9979 3187997 PK04_103202 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2cccc(OCCO)c2)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K03 compound treatment 1.175308E7 -1770000.0 -1.0 1.098832E7 -392000.0 -0.22 1.057668E7 -1427366.25 -0.838113577799902 -1.1866 -0.8985 3070657 PK04_103203 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K04 compound treatment 1.102456E7 -2500000.0 -1.41 9841160.0 -1540000.0 -0.87 1.02272E7 -1776846.25 -1.04331944782065 -1.9141 -0.98 3187998 PK04_103204 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K05 compound treatment 1.214196E7 -1390000.0 -0.78 1.066296E7 -717000.0 -0.4 1.0837E7 -1167046.25 -0.68526021828347 -1.078 -0.9689 3070658 PK04_103205 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K06 compound treatment 1.203264E7 -1490000.0 -0.84 1.059652E7 -784000.0 -0.44 1.090332E7 -1100726.25 -0.646318781578147 -1.1125 -0.9694 3187999 PK04_103206 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K07 mock treatment 1.3286E7 -241000.0 -0.14 1.088408E7 -496000.0 -0.28 1.119956E7 -804486.25 -0.472374101095865 -0.5122 -0.9061 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K08 mock treatment 1.302928E7 -498000.0 -0.28 1.07508E7 -630000.0 -0.35 1.241692E7 412873.75 0.242429086292437 -0.2261 -0.4412 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K09 compound treatment 1.23834E7 -1140000.0 -0.64 1.047196E7 -908000.0 -0.51 1.165832E7 -345726.25 -0.203001762390587 -0.7833 -0.9261 3188000 PK04_103207 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K10 compound treatment 1.276988E7 -757000.0 -0.43 1.06268E7 -754000.0 -0.42 1.145348E7 -550566.25 -0.323278660682481 -0.6771 -0.9926 3070659 PK04_103208 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccc(OCCO)cc2)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K11 compound treatment 1.255468E7 -972000.0 -0.55 9624720.0 -1760000.0 -0.99 1.112248E7 -881566.25 -0.517633539293186 -1.1848 -0.9538 3188108 PK04_103209 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K12 compound treatment 1.293584E7 -591000.0 -0.33 1.015528E7 -1230000.0 -0.69 1.0715E7 -1289046.25 -0.756895551185301 -1.0269 -0.9539 3188109 PK04_103210 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K13 compound treatment 1.227976E7 -1250000.0 -0.7 1.13996E7 19100.0 0.01 1.098792E7 -1016126.25 -0.596643788434746 -0.7427 -0.8071 3070660 PK04_103211 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K14 compound treatment 1.322504E7 -302000.0 -0.17 1.155332E7 173000.0 0.1 1.15888E7 -415246.25 -0.243822158647434 -0.1825 -0.584 3188110 PK04_103212 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K15 mock treatment 1.233076E7 -1200000.0 -0.67 1.139416E7 13700.0 0.01 1.27244E7 720353.75 0.422973612199445 -0.1393 -0.1754 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K16 mock treatment 1.326888E7 -258000.0 -0.14 1.089464E7 -486000.0 -0.27 1.258096E7 576913.75 0.338749250302407 -0.046 -0.1003 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K17 compound treatment 1.179328E7 -1730000.0 -0.97 1.01942E7 -1190000.0 -0.67 1.087736E7 -1126686.25 -0.661561840939881 -1.3297 -0.9825 3070661 PK04_103213 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K18 compound treatment 1.248928E7 -1040000.0 -0.58 1.10322E7 -348000.0 -0.2 1.097112E7 -1032926.25 -0.606508326080244 -0.7999 -0.9261 3188111 PK04_103214 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K19 compound treatment 1.26054E7 -922000.0 -0.52 1.08732E7 -507000.0 -0.29 1.196444E7 -39606.25 -0.0232557942929766 -0.4771 -0.8065 3188112 PK04_103215 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K20 compound treatment 1.1741E7 -1790000.0 -1.0 1.000868E7 -1370000.0 -0.77 1.045652E7 -1547526.25 -0.908668508959607 -1.5496 -0.9944 3070662 PK04_103216 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K21 compound treatment 1.182896E7 -1700000.0 -0.95 1.00938E7 -1290000.0 -0.72 1.042512E7 -1578926.25 -0.92710579955893 -1.5041 -0.9931 3188113 PK04_103217 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K22 compound treatment 1.179828E7 -1730000.0 -0.97 1.049648E7 -884000.0 -0.5 1.042756E7 -1576486.25 -0.925673092900894 -1.3823 -0.9661 3188114 PK04_103218 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K23 mock treatment 1.274004E7 -787000.0 -0.44 1.070752E7 -673000.0 -0.38 1.182552E7 -178526.25 -0.104826125823488 -0.5344 -0.9035 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 K24 mock treatment 1.122672E7 -2300000.0 -1.29 1.040916E7 -971000.0 -0.55 1.020216E7 -1801886.25 -1.05802230631133 -1.6725 -0.9518 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L01 compound treatment 8096560.0 -5430000.0 -3.05 7416400.0 -3960000.0 -2.23 6902640.0 -5101406.25 -2.99541749988714 -4.7787 -0.9909 3070663 PK04_103219 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L02 compound treatment 9424560.0 -4100000.0 -2.3 8469840.0 -2910000.0 -1.64 9195360.0 -2808686.25 -1.64918995520939 -3.2285 -0.9863 3188115 PK04_103220 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L03 compound treatment 8227400.0 -5300000.0 -2.98 6590080.0 -4790000.0 -2.7 7324200.0 -4679846.25 -2.74788806596832 -4.8619 -0.9991 3070664 PK04_103221 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L04 compound treatment 1.255136E7 -976000.0 -0.55 1.030072E7 -1080000.0 -0.61 1.084864E7 -1155406.25 -0.678425502914804 -1.059 -0.9962 3188116 PK04_103222 CC1C=C(CCCO)C=C(C(=O)OCCS(=O)(=O)C)C(=CN1Cc2cccc(OC(F)(F)F)c2)C(=O)OCCS(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L05 compound treatment 1.012576E7 -3400000.0 -1.91 8510080.0 -2870000.0 -1.62 7550280.0 -4453766.25 -2.61513957365319 -3.5457 -0.9797 3070665 PK04_103223 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L06 compound treatment 1.294268E7 -584000.0 -0.33 9513840.0 -1870000.0 -1.05 1.190952E7 -94526.25 -0.0555034375959975 -0.8282 -0.7514 3188117 PK04_103224 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L07 mock treatment 1.327136E7 -256000.0 -0.14 1.125724E7 -123000.0 -0.07 1.151192E7 -492126.25 -0.288964161872784 -0.2898 -0.878 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L08 mock treatment 1.354468E7 17700.0 0.01 1.141816E7 37700.0 0.02 1.18904E7 -113646.25 -0.06673022091635 -0.0205 -0.2904 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L09 compound treatment 1.049704E7 -3030000.0 -1.7 8481800.0 -2900000.0 -1.63 9533960.0 -2470086.25 -1.45037254766381 -2.762 -0.9978 3188118 PK04_103225 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L10 compound treatment 1.289336E7 -634000.0 -0.36 1.146164E7 81200.0 0.05 1.19294E7 -74646.25 -0.0438304013821582 -0.2044 -0.5654 3188119 PK04_103226 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L11 compound treatment 9242160.0 -4280000.0 -2.41 2300200.0 -9080000.0 -5.11 2730440.0 -9273606.25 -5.44522845015779 -7.4844 -0.9538 3070666 PK04_103227 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L12 compound treatment 1.272456E7 -802000.0 -0.45 9620960.0 -1760000.0 -0.99 1.138764E7 -616406.25 -0.361938253455075 -1.041 -0.9078 3188120 PK04_103228 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L13 compound treatment 1.31436E7 -383000.0 -0.22 1.251344E7 1130000.0 0.64 1.122024E7 -783806.25 -0.460231324994145 -0.0218 -0.0268 3188121 PK04_103229 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L14 compound treatment 1.36256E7 98600.0 0.06 9878000.0 -1500000.0 -0.85 1.0765E7 -1239046.25 -0.727536808192748 -0.8764 -0.7846 3188122 PK04_103230 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CO)cc3)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L15 mock treatment 1.325888E7 -268000.0 -0.15 1.141808E7 37600.0 0.02 1.220216E7 198113.75 0.116327413390821 -0.0076 -0.0395 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L16 mock treatment 1.37982E7 271000.0 0.15 1.11766E7 -204000.0 -0.11 1.222192E7 217873.75 0.127929988621478 0.0956 0.4161 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L17 compound treatment 1.338188E7 -145000.0 -0.08 1.153676E7 156000.0 0.09 1.106848E7 -935566.25 -0.549340981725144 -0.3134 -0.5574 3070709 PK04_103231 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L18 compound treatment 1.293668E7 -590000.0 -0.33 1.023644E7 -1140000.0 -0.64 1.198532E7 -18726.25 -0.0109955832192862 -0.5696 -0.7863 3188123 PK04_103232 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L19 compound treatment 1.3423E7 -104000.0 -0.06 1.10368E7 -344000.0 -0.19 1.151524E7 -488806.25 -0.287014741338079 -0.3111 -0.8863 3070710 PK04_103233 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L20 compound treatment 1.228856E7 -1240000.0 -0.7 1.007696E7 -1300000.0 -0.73 1.098116E7 -1022886.25 -0.60061309048734 -1.172 -0.9966 3188124 PK04_103234 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L21 compound treatment 1.156896E7 -1960000.0 -1.1 1.048484E7 -896000.0 -0.5 1.079676E7 -1207286.25 -0.708888134643878 -1.3353 -0.9523 3070711 PK04_103235 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L22 compound treatment 1.2309E7 -1220000.0 -0.68 1.019624E7 -1180000.0 -0.67 1.091528E7 -1088766.25 -0.639296170254328 -1.1489 -0.9996 3188125 PK04_103236 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L23 mock treatment 1.231472E7 -1210000.0 -0.68 1.055524E7 -825000.0 -0.46 1.09192E7 -1084846.25 -0.636994444803712 -1.0291 -0.9879 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 L24 mock treatment 1.10672E7 -2460000.0 -1.38 1.131584E7 -64600.0 -0.04 1.01666E7 -1837446.25 -1.07890224432763 -1.4416 -0.8222 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M01 compound treatment 1.16794E7 -1850000.0 -1.04 1.002372E7 -1360000.0 -0.76 1.089936E7 -1104686.25 -0.648643994023157 -1.4146 -0.9806 3070712 PK04_103237 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M02 compound treatment 1.148328E7 -2040000.0 -1.15 1.019408E7 -1190000.0 -0.67 1.051084E7 -1493206.25 -0.876773170572496 -1.5545 -0.9769 3188126 PK04_103238 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccc(OCCO)cc3)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M03 compound treatment 1.172812E7 -1800000.0 -1.01 1.046728E7 -913000.0 -0.51 1.088012E7 -1123926.25 -0.659941238326692 -1.2611 -0.9614 3070713 PK04_103239 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M04 compound treatment 1.165072E7 -1880000.0 -1.05 1.023416E7 -1150000.0 -0.65 1.080144E7 -1202606.25 -0.706140156299774 -1.3887 -0.9757 3188127 PK04_103240 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M05 compound treatment 1.275296E7 -774000.0 -0.43 1.105248E7 -328000.0 -0.18 1.121524E7 -788806.25 -0.463167199293401 -0.625 -0.9448 3188128 PK04_103241 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M06 compound treatment 1.251E7 -1020000.0 -0.57 1.013536E7 -1250000.0 -0.7 1.10846E7 -919446.25 -0.539875722984345 -1.0461 -0.9934 3070714 PK04_103242 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M07 compound treatment 1.312652E7 -400000.0 -0.22 1.06952E7 -685000.0 -0.39 1.126136E7 -742686.25 -0.436086694757069 -0.6043 -0.9683 3188237 PK04_103243 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M08 compound treatment 1.217408E7 -1350000.0 -0.76 1.020844E7 -1170000.0 -0.66 1.0554E7 -1450046.25 -0.851430703621324 -1.3112 -0.9947 3070715 PK04_103244 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccc(CO)o2)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M09 mock treatment 1.366944E7 142000.0 0.08 1.119628E7 -184000.0 -0.1 1.180312E7 -200926.25 -0.117978842684152 -0.0818 -0.4639 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M10 mock treatment 1.405304E7 526000.0 0.3 1.15962E7 216000.0 0.12 1.206676E7 62713.75 0.0368239373669852 0.262 0.8146 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M11 compound treatment 1.404E7 513000.0 0.29 1.091016E7 -470000.0 -0.26 1.250344E7 499393.75 0.293231455166752 0.1828 0.3739 3188238 PK04_103245 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M12 compound treatment 1.35724E7 45400.0 0.03 9792840.0 -1590000.0 -0.89 9906280.0 -2097766.25 -1.23175560384406 -1.2124 -0.7966 3188239 PK04_103246 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M13 mock treatment 1.574608E7 2220000.0 1.25 1.236328E7 983000.0 0.55 1.150752E7 -496526.25 -0.291547731256129 0.8707 0.6244 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M14 mock treatment 1.454616E7 1020000.0 0.57 1.164544E7 265000.0 0.15 1.25442E7 540153.75 0.317164702454282 0.5997 0.8935 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M15 compound treatment 1.330412E7 -223000.0 -0.13 1.091972E7 -461000.0 -0.26 1.163792E7 -366126.25 -0.214980129531549 -0.3461 -0.9631 3070716 PK04_103247 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M16 compound treatment 1.332356E7 -203000.0 -0.11 1.128676E7 -93700.0 -0.05 1.169056E7 -313486.25 -0.184071244908988 -0.2027 -0.909 3188240 PK04_103248 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M17 compound treatment 1.355032E7 23300.0 0.01 1.134052E7 -39900.0 -0.02 1.191812E7 -85926.25 -0.0504537338012783 -0.0345 -0.6085 3070717 PK04_103249 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M18 compound treatment 1.283908E7 -688000.0 -0.39 1.148532E7 105000.0 0.06 1.069088E7 -1313166.25 -0.771058208804909 -0.6342 -0.7336 3188241 PK04_103250 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M19 compound treatment 1.217372E7 -1350000.0 -0.76 1.101968E7 -361000.0 -0.2 1.099816E7 -1005886.25 -0.590631117869871 -0.8971 -0.9119 3188242 PK04_103251 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M20 compound treatment 1.276796E7 -759000.0 -0.43 1.050544E7 -875000.0 -0.49 1.11254E7 -878646.25 -0.515918988702421 -0.8284 -0.9969 3070718 PK04_103252 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccccc2OCCO)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M21 compound treatment 1.20534E7 -1470000.0 -0.83 1.015936E7 -1220000.0 -0.69 1.145536E7 -548686.25 -0.322174771945961 -1.0607 -0.9445 3188243 PK04_103253 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M22 compound treatment 1.129944E7 -2230000.0 -1.25 9512440.0 -1870000.0 -1.05 9943680.0 -2060366.25 -1.20979526408563 -2.0279 -0.9973 3188244 PK04_103254 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M23 compound treatment 1.181548E7 -1710000.0 -0.96 1.03992E7 -981000.0 -0.55 1.08146E7 -1189446.25 -0.698412935144134 -1.2772 -0.9747 3188245 PK04_103255 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 M24 compound treatment 1.097452E7 -2550000.0 -1.43 9630800.0 -1750000.0 -0.98 1.00822E7 -1921846.25 -1.12845980249906 -2.0479 -0.9877 3070768 PK04_103256 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N01 compound treatment 1.287124E7 -656000.0 -0.37 1.101864E7 -362000.0 -0.2 1.101452E7 -989526.25 -0.581024937162708 -0.6657 -0.9279 3188246 PK04_103257 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N02 compound treatment 1.3164E7 -363000.0 -0.2 1.164556E7 265000.0 0.15 1.193896E7 -65086.25 -0.0382170097219819 -0.0536 -0.2098 3188247 PK04_103258 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)CCCO)C(=O)OCCS(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N03 compound treatment 1.309416E7 -433000.0 -0.24 1.169464E7 314000.0 0.18 1.263204E7 627993.75 0.3687421421436 0.1746 0.3671 3070772 PK04_103259 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N04 compound treatment 1.353136E7 4370.0 0.0 1.18302E7 450000.0 0.25 1.20188E7 14753.75 0.00866303108852777 0.1526 0.6023 3188248 PK04_103260 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N05 compound treatment 1.362668E7 99700.0 0.06 1.242756E7 1050000.0 0.59 1.187332E7 -130726.25 -0.0767591675226063 0.3283 0.5499 3188249 PK04_103261 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N06 compound treatment 1.131624E7 -2210000.0 -1.24 1.15784E7 198000.0 0.11 1.057728E7 -1426766.25 -0.837761272883991 -1.1363 -0.7565 3188250 PK04_103262 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N07 compound treatment 1.429952E7 773000.0 0.43 1.429336E7 2910000.0 1.64 1.422792E7 2223873.75 1.30580275748273 1.9511 0.9115 3070060 PK04_103263 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N08 compound treatment 1.329736E7 -230000.0 -0.13 1.083772E7 -543000.0 -0.31 1.139652E7 -607526.25 -0.356724140699598 -0.4568 -0.9379 3188251 PK04_103264 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CN4CCCC4)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N09 mock treatment 1.626224E7 2740000.0 1.54 1.153424E7 154000.0 0.09 1.236132E7 357273.75 0.209782164084717 1.0581 0.6813 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N10 mock treatment 1.688884E7 3360000.0 1.89 1.156656E7 186000.0 0.1 1.400704E7 2002993.75 1.17610757443883 1.8297 0.8216 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N11 compound treatment 1.352012E7 -6870.0 0.0 1.150984E7 129000.0 0.07 1.204384E7 39793.75 0.0233658895791986 0.0533 0.6961 3070061 PK04_103265 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N12 compound treatment 1.583264E7 2310000.0 1.3 1.458588E7 3210000.0 1.8 1.425936E7 2255313.75 1.32426353507645 2.554 0.9877 3188252 PK04_103266 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N13 mock treatment 1.4073E7 546000.0 0.31 1.463652E7 3260000.0 1.83 1.271096E7 706913.75 0.415081982083046 1.4749 0.7746 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N14 mock treatment 1.407508E7 548000.0 0.31 1.198964E7 609000.0 0.34 1.31906E7 1186553.75 0.696714531862015 0.778 0.9313 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N15 compound treatment 1.360744E7 80500.0 0.05 1.121656E7 -164000.0 -0.09 1.198676E7 -17286.25 -0.0101500514211006 -0.033 -0.32 3070062 PK04_103267 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N16 compound treatment 1.302912E7 -498000.0 -0.28 1.102932E7 -351000.0 -0.2 1.156812E7 -435926.25 -0.255964934749154 -0.4234 -0.9902 3188253 PK04_103268 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)c3ccc(CO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N17 compound treatment 1.34144E7 -113000.0 -0.06 1.074752E7 -633000.0 -0.36 1.161504E7 -389006.25 -0.228414690324941 -0.3741 -0.8742 3070063 PK04_103269 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N18 compound treatment 1.376016E7 233000.0 0.13 1.089236E7 -488000.0 -0.27 1.231496E7 310913.75 0.182560737582022 0.0224 0.0631 3188254 PK04_103270 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2ccc(CN3CCCC3)cc2)CCCO)C(=O)OCCS(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N19 compound treatment 1.346228E7 -64700.0 -0.04 1.139892E7 18500.0 0.01 1.243512E7 431073.75 0.253115668741726 0.1312 0.5125 3070064 PK04_103271 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N20 compound treatment 1.363984E7 113000.0 0.06 1.099112E7 -389000.0 -0.22 1.181584E7 -188206.25 -0.110509978466846 -0.1537 -0.6065 3188255 PK04_103272 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N21 compound treatment 1.309244E7 -435000.0 -0.24 1.170784E7 327000.0 0.18 1.268748E7 683433.75 0.401295116373743 0.1972 0.3908 3070065 PK04_103273 CCCCC(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N22 compound treatment 1.23474E7 -1180000.0 -0.66 1.029572E7 -1080000.0 -0.61 1.111308E7 -890966.25 -0.523152982975786 -1.0371 -0.9954 3188256 PK04_103274 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2sc3ccccc3c2Cl)c4ccc(CN5CCCC5)cc4)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N23 compound treatment 1.3301E7 -226000.0 -0.13 1.145492E7 74500.0 0.04 1.156996E7 -434086.25 -0.254884533007028 -0.1962 -0.6818 3070066 PK04_103275 CC(C)C(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 N24 compound treatment 1.313004E7 -397000.0 -0.22 1.199868E7 618000.0 0.35 1.0719E7 -1285046.25 -0.754546851745897 -0.3634 -0.4224 3188257 PK04_103276 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O01 compound treatment 1.127864E7 -2250000.0 -1.26 1.003776E7 -1340000.0 -0.76 1.27058E7 701753.75 0.412052159806215 -0.9276 -0.6069 3188258 PK04_103277 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O02 compound treatment 1.15754E7 -1950000.0 -1.1 1.032264E7 -1060000.0 -0.6 1.027676E7 -1727286.25 -1.01421906176644 -1.5622 -0.9717 3070067 PK04_103278 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O03 compound treatment 1.20934E7 -1430000.0 -0.81 1.423436E7 2850000.0 1.61 1.307648E7 1072433.75 0.629706136855811 0.8262 0.4339 3188259 PK04_103279 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O04 compound treatment 1.327408E7 -253000.0 -0.14 1.0877E7 -503000.0 -0.28 1.232028E7 316233.75 0.185684507836429 -0.1384 -0.3768 3188369 PK04_103280 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O05 compound treatment 1.253172E7 -995000.0 -0.56 1.214272E7 762000.0 0.43 1.213048E7 126433.75 0.0742387194366956 -0.0322 -0.0454 3070068 PK04_103281 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O06 compound treatment 1.244136E7 -1090000.0 -0.61 1.256916E7 1190000.0 0.67 1.179092E7 -213126.25 -0.125142375974335 -0.038 -0.0416 3188370 PK04_103282 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O07 compound treatment 1.32246E7 -302000.0 -0.17 1.32072E7 1830000.0 1.03 1.2337E7 332953.75 0.195502071493139 0.6085 0.5738 3070069 PK04_103283 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O08 compound treatment 1.343076E7 -96200.0 -0.05 1.043684E7 -944000.0 -0.53 1.108676E7 -917286.25 -0.538607425287066 -0.6488 -0.8555 3188371 PK04_103284 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccc(CO)o3)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O09 compound treatment 1.567992E7 2150000.0 1.21 1.111256E7 -268000.0 -0.15 1.232416E7 320113.75 0.187962746292651 0.7196 0.5836 3188372 PK04_103285 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O10 compound treatment 1.358488E7 57900.0 0.03 1.198244E7 602000.0 0.34 1.395336E7 1949313.75 1.14458802796202 0.8752 0.733 3070070 PK04_103286 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O11 mock treatment 1.44078E7 881000.0 0.49 1.17962E7 416000.0 0.23 1.211456E7 110513.75 0.0648908956678665 0.4582 0.8314 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O12 mock treatment 1.455404E7 1030000.0 0.58 1.3169E7 1790000.0 1.01 1.267468E7 670633.75 0.39377927816765 1.1417 0.9317 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O13 compound treatment 1.421128E7 684000.0 0.38 1.056692E7 -814000.0 -0.46 1.214972E7 145673.75 0.0855359637402302 0.0069 0.0114 3188373 PK04_103287 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O14 compound treatment 1.121708E7 -2310000.0 -1.3 1.002836E7 -1350000.0 -0.76 9932760.0 -2071286.25 -1.2162072135552 -1.8907 -0.9774 3188374 PK04_103288 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccccc3OCCO)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O15 compound treatment 1.209156E7 -1440000.0 -0.81 1.077644E7 -604000.0 -0.34 1.138208E7 -621966.25 -0.365202945675847 -0.8726 -0.9203 3070071 PK04_103289 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O16 compound treatment 1.0707E7 -2820000.0 -1.58 9321080.0 -2060000.0 -1.16 9313040.0 -2691006.25 -1.58009121770211 -2.496 -0.9906 3188375 PK04_103290 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O17 compound treatment 1.123056E7 -2300000.0 -1.29 9773760.0 -1610000.0 -0.9 1.037848E7 -1625566.25 -0.954491635022384 -1.8179 -0.987 3070072 PK04_103291 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccc(OCCO)cc2)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O18 compound treatment 1.28088E7 -718000.0 -0.4 1.063668E7 -744000.0 -0.42 1.15118E7 -492246.25 -0.289034622855966 -0.6415 -0.988 3188376 PK04_103292 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O19 compound treatment 1.205772E7 -1470000.0 -0.83 1.040684E7 -974000.0 -0.55 1.033984E7 -1664206.25 -0.97718007160703 -1.3571 -0.9752 3188377 PK04_103293 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O20 compound treatment 1.11364E7 -2390000.0 -1.34 1.078092E7 -600000.0 -0.34 1.024664E7 -1757406.25 -1.03190476854515 -1.5659 -0.9068 3070073 PK04_103294 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3cccc(OCCO)c3)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O21 compound treatment 1.138912E7 -2140000.0 -1.2 9622800.0 -1760000.0 -0.99 1.091104E7 -1093006.25 -0.641785791660097 -1.635 -0.9715 3188378 PK04_103295 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O22 compound treatment 1.03914E7 -3140000.0 -1.76 9089200.0 -2290000.0 -1.29 8951320.0 -3052726.25 -1.79248410800744 -2.7964 -0.99 3188379 PK04_103296 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O23 compound treatment 1.146588E7 -2060000.0 -1.16 1.006472E7 -1320000.0 -0.74 1.057476E7 -1429286.25 -0.839240953530816 -1.5805 -0.9815 3070074 PK04_103297 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2cccc(OCCO)c2)/C(=C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 O24 compound treatment 9407480.0 -4120000.0 -2.31 9398800.0 -1980000.0 -1.12 8807040.0 -3197006.25 -1.87720169678675 -3.0637 -0.963 3188380 PK04_103298 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P01 compound treatment 1.022316E7 -3300000.0 -1.86 9463640.0 -1920000.0 -1.08 9582400.0 -2421646.25 -1.42192979745263 -2.5153 -0.9769 3070075 PK04_103299 COCC(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P02 compound treatment 1.179188E7 -1740000.0 -0.97 1.104776E7 -333000.0 -0.19 1.071996E7 -1284086.25 -0.75398316388044 -1.1061 -0.8875 3188381 PK04_103300 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)c3ccc(CO)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P03 compound treatment 1.0612E7 -2910000.0 -1.64 9325760.0 -2050000.0 -1.16 9855320.0 -2148726.25 -1.26167803470207 -2.3415 -0.9886 3188382 PK04_103301 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P04 compound treatment 1.137728E7 -2150000.0 -1.21 1.059952E7 -781000.0 -0.44 1.084772E7 -1156326.25 -0.678965703785867 -1.3429 -0.924 3070118 PK04_103302 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P05 compound treatment 1.145692E7 -2070000.0 -1.16 1.094916E7 -431000.0 -0.24 9695560.0 -2308486.25 -1.35548509031188 -1.5941 -0.8845 3188383 PK04_103303 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P06 compound treatment 1.179444E7 -1730000.0 -0.97 1.078268E7 -598000.0 -0.34 1.099172E7 -1012326.25 -0.594412523967312 -1.0993 -0.9246 3070119 PK04_103304 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cccc(OC(F)(F)F)c3)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P07 compound treatment 1.151492E7 -2010000.0 -1.13 1.056208E7 -818000.0 -0.46 1.11988E7 -805246.25 -0.472820353989352 -1.1914 -0.9103 3188384 PK04_103305 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P08 compound treatment 1.153836E7 -1990000.0 -1.12 1.086608E7 -514000.0 -0.29 1.063272E7 -1371326.25 -0.805208298653848 -1.2769 -0.9075 3188385 PK04_103306 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3ccc(CN4CCCC4)cc3)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P09 compound treatment 1.233344E7 -1190000.0 -0.67 1.061992E7 -761000.0 -0.43 1.0515E7 -1489046.25 -0.874330523155516 -1.139 -0.9636 3070120 PK04_103307 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P10 compound treatment 1.105804E7 -2470000.0 -1.39 1.062228E7 -758000.0 -0.43 9826160.0 -2177886.25 -1.27880005361533 -1.7854 -0.9231 3188386 PK04_103308 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P11 mock treatment 1.335432E7 -173000.0 -0.1 1.196328E7 583000.0 0.33 1.203972E7 35673.75 0.0209467291566122 0.1455 0.4245 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P12 mock treatment 1.32126E7 -314000.0 -0.18 1.148536E7 105000.0 0.06 1.19688E7 -35246.25 -0.0206957119040259 -0.0798 -0.426 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P13 compound treatment 9562400.0 -3960000.0 -2.23 9460400.0 -1920000.0 -1.08 8875560.0 -3128486.25 -1.83696847538976 -2.9702 -0.9636 3070121 PK04_103309 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P14 compound treatment 1.252028E7 -1010000.0 -0.57 1.139084E7 10400.0 0.01 1.155196E7 -452086.25 -0.265453680484347 -0.4763 -0.7625 3188387 PK04_103310 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P15 compound treatment 1.289512E7 -632000.0 -0.35 1.096348E7 -417000.0 -0.23 1.190676E7 -97286.25 -0.0571240402091865 -0.3734 -0.8698 3188388 PK04_103311 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P16 compound treatment 1.258128E7 -946000.0 -0.53 1.067796E7 -702000.0 -0.4 1.130032E7 -703726.25 -0.413210362217271 -0.7736 -0.991 3070122 PK04_103312 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2ccc(CN3CCCC3)cc2)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P17 compound treatment 1.098288E7 -2540000.0 -1.43 1.060692E7 -774000.0 -0.44 1.013248E7 -1871566.25 -1.09893665054575 -1.7109 -0.9226 3188389 PK04_103313 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P18 compound treatment 1.128124E7 -2250000.0 -1.26 1.103664E7 -344000.0 -0.19 1.163216E7 -371886.25 -0.218362256724291 -0.9661 -0.7462 3188390 PK04_103314 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)c5ccc(CO)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P19 compound treatment 1.089196E7 -2640000.0 -1.48 1.000188E7 -1380000.0 -0.78 9971320.0 -2032726.25 -1.19356575095935 -1.9916 -0.9698 3070123 PK04_103315 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P20 compound treatment 1.1636E7 -1890000.0 -1.06 1.012348E7 -1260000.0 -0.71 1.152292E7 -481126.25 -0.282505238414422 -1.1848 -0.9064 3188503 PK04_103316 COP(=O)(OC)/N=C\1/CC(=CC(C)N1Cc2cccc(OC(F)(F)F)c2)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P21 compound treatment 1.142456E7 -2100000.0 -1.18 1.015748E7 -1220000.0 -0.69 9883560.0 -2120486.25 -1.24509621665988 -1.7981 -0.9725 3188504 PK04_103317 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P22 compound treatment 1.179232E7 -1730000.0 -0.97 1.044836E7 -932000.0 -0.52 1.11074E7 -896646.25 -0.52648813617974 -1.1694 -0.9543 3070124 PK04_103318 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cc3OCOc3cc2Br)c4ccc(CN5CCCC5)cc4)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P23 compound treatment 9383360.0 -4140000.0 -2.33 8729720.0 -2650000.0 -1.49 9948480.0 -2055566.25 -1.20697682475835 -2.9021 -0.962 3188505 PK04_103319 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2103 P24 compound treatment 7082720.0 -6440000.0 -3.62 7209040.0 -4170000.0 -2.35 7481960.0 -4522086.25 -2.65525536007821 -4.9785 -0.9827 3188506 PK04_103320 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)c5ccc(CO)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A01 mock treatment 9108680.0 -2170000.0 -1.22 8941320.0 -2070000.0 -1.16 8582880.0 -3414874.0331492 -2.00512818182345 -2.5327 -0.9671 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A02 mock treatment 9939520.0 -1340000.0 -0.75 9583600.0 -1420000.0 -0.8 9924560.0 -2073194.0331492 -1.21732741585846 -1.5997 -0.9754 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A03 mock treatment 1.02508E7 -1030000.0 -0.58 1.0059E7 -949000.0 -0.53 1.037488E7 -1622874.0331492 -0.952910832970327 -1.1916 -0.9646 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A04 mock treatment 1.05538E7 -724000.0 -0.41 1.04926E7 -516000.0 -0.29 1.062116E7 -1376594.0331492 -0.808301408486205 -0.869 -0.9145 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A05 mock treatment 1.052112E7 -756000.0 -0.42 9942640.0 -1070000.0 -0.6 1.104848E7 -949274.0331492 -0.557389847374644 -0.9134 -0.9902 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A06 mock treatment 1.077584E7 -502000.0 -0.28 1.086536E7 -143000.0 -0.08 1.115368E7 -844074.0331492 -0.495619052118311 -0.4953 -0.8602 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A07 mock treatment 1.083684E7 -441000.0 -0.25 1.032788E7 -680000.0 -0.38 1.1256E7 -741754.0331492 -0.435539320458349 -0.6155 -0.976 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A08 mock treatment 1.066856E7 -609000.0 -0.34 1.04266E7 -582000.0 -0.33 1.114228E7 -855474.0331492 -0.502312845520614 -0.6765 -0.98 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A09 mock treatment 9841360.0 -1440000.0 -0.81 1.043904E7 -569000.0 -0.32 1.116176E7 -835994.0331492 -0.490874679250715 -0.9341 -0.9368 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A10 mock treatment 1.041628E7 -861000.0 -0.48 1.054524E7 -463000.0 -0.26 1.169052E7 -307234.0331492 -0.180400100355861 -0.5339 -0.9232 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A11 mock treatment 1.1307E7 29500.0 0.02 1.03254E7 -683000.0 -0.38 1.142168E7 -576074.0331492 -0.338256189678224 -0.4077 -0.7958 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A12 mock treatment 8016200.0 -3260000.0 -1.83 8033800.0 -2970000.0 -1.67 8627640.0 -3370114.0331492 -1.97884623509652 -3.1668 -0.9977 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A13 mock treatment 1.110536E7 -172000.0 -0.1 1.047252E7 -536000.0 -0.3 1.122644E7 -771314.0331492 -0.452896209315547 -0.4914 -0.8892 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A14 mock treatment 1.042424E7 -853000.0 -0.48 1.10338E7 25600.0 0.01 1.146648E7 -531274.0331492 -0.311950755956896 -0.4485 -0.7841 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A15 mock treatment 1.058024E7 -697000.0 -0.39 1.07634E7 -245000.0 -0.14 1.127336E7 -724394.0331492 -0.425345964891335 -0.5513 -0.9274 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A16 mock treatment 1.073236E7 -545000.0 -0.31 1.06814E7 -327000.0 -0.18 1.090192E7 -1095834.0331492 -0.643446194834417 -0.6545 -0.8893 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A17 mock treatment 9813160.0 -1460000.0 -0.82 1.075528E7 -253000.0 -0.14 1.127268E7 -725074.0331492 -0.425745243796034 -0.8029 -0.8568 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A18 mock treatment 1.059368E7 -684000.0 -0.38 1.003284E7 -975000.0 -0.55 1.168576E7 -311994.0331492 -0.183195052688752 -0.6445 -0.9278 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A19 mock treatment 1.057152E7 -706000.0 -0.4 1.002752E7 -981000.0 -0.55 1.108092E7 -916834.0331492 -0.538341894921075 -0.8585 -0.9901 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A20 mock treatment 1.001448E7 -1260000.0 -0.71 9962080.0 -1050000.0 -0.59 1.078816E7 -1209594.0331492 -0.710243206891075 -1.1597 -0.9964 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A21 mock treatment 9950280.0 -1330000.0 -0.75 1.020016E7 -808000.0 -0.45 1.039232E7 -1605434.0331492 -0.942670503414524 -1.2373 -0.9628 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A22 mock treatment 9916120.0 -1360000.0 -0.76 9319920.0 -1690000.0 -0.95 1.028884E7 -1708914.0331492 -1.00343135791191 -1.5695 -0.9937 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A23 mock treatment 9081040.0 -2200000.0 -1.23 8691120.0 -2320000.0 -1.3 9786480.0 -2211274.0331492 -1.2984045205067 -2.215 -0.9997 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 A24 mock treatment 9369400.0 -1910000.0 -1.07 8773840.0 -2230000.0 -1.26 1.024504E7 -1752714.0331492 -1.02914961677339 -1.9391 -0.9961 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B01 mock treatment 9043080.0 -2230000.0 -1.26 1.067056E7 -338000.0 -0.19 1.082908E7 -1168674.0331492 -0.68621601162597 -1.2305 -0.8528 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B02 mock treatment 1.070468E7 -573000.0 -0.32 1.124732E7 239000.0 0.13 1.07726E7 -1225154.0331492 -0.719379647710358 -0.5234 -0.6547 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B03 compound treatment 8654880.0 -2620000.0 -1.47 8070920.0 -2940000.0 -1.65 8541640.0 -3456114.0331492 -2.02934327304371 -2.9768 -0.991 2277 HSCI1_000001 CCc1nc([nH]c1c2ccncc2)c3ccc(OC)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B04 compound treatment 4602320.0 -6680000.0 -3.75 3997920.0 -7010000.0 -3.95 4069320.0 -7928434.0331492 -4.65537714225286 -7.1308 -0.9956 656 HSCI1_000002 Oc1c(Br)cc(/C=C/2\C(=O)Nc3ccc(I)cc23)cc1Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B05 compound treatment 8990640.0 -2290000.0 -1.28 7913560.0 -3090000.0 -1.74 8422920.0 -3574834.0331492 -2.09905267240523 -2.9593 -0.9815 2114187 HSCI1_000003 CCOC(=O)c1cccc(NC(=O)CBr)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B06 compound treatment 1.141352E7 136000.0 0.08 1.16232E7 615000.0 0.35 1.216876E7 171005.9668508 0.100410404619316 0.3019 0.8195 1362420 HSCI1_000004 Oc1c(I)cc(Cl)cc1C(=O)Nc2cc(ccc2Cl)S(=O)(=O)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B07 compound treatment 1.134916E7 71600.0 0.04 1.082848E7 -180000.0 -0.1 1.127892E7 -718834.0331492 -0.422081272670563 -0.2789 -0.6398 3175973 HSCI1_000005 COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B08 compound treatment 1.066932E7 -608000.0 -0.34 1.055624E7 -452000.0 -0.25 1.089284E7 -1104914.0331492 -0.648777742561865 -0.7187 -0.926 3175974 HSCI1_000006 CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1CCC(O)C(O)C1O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B09 compound treatment 1.160572E7 328000.0 0.18 1.152428E7 516000.0 0.29 1.23442E7 346445.9668508 0.203424362031588 0.3916 0.9798 9 HSCI1_000007 [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc34)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B10 compound treatment 8879360.0 -2400000.0 -1.35 6629040.0 -4380000.0 -2.47 4941480.0 -7056274.0331492 -4.14326671648515 -4.593 -0.9175 571 HSCI1_000008 CCCCCCCCCCCCCCCCCCOC[C@H](COC(=O)OC1C(O)C(O)C(O)C(CO)C1O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B11 mock treatment 1.23964E7 1120000.0 0.63 1.118452E7 176000.0 0.1 1.241532E7 417565.9668508 0.245184238064197 0.5617 0.8238 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B12 mock treatment 1.222048E7 943000.0 0.53 1.180216E7 794000.0 0.45 1.297188E7 974125.9668508 0.57198227806291 0.894 0.995 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B13 mock treatment 1.214604E7 869000.0 0.49 1.217332E7 1170000.0 0.66 1.257212E7 574365.9668508 0.337253256088845 0.855 0.967 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B14 mock treatment 1.185352E7 576000.0 0.32 1.159872E7 590000.0 0.33 1.274404E7 746285.9668508 0.438200357994441 0.6317 0.99 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B15 compound treatment 1.10604E7 -217000.0 -0.12 9567280.0 -1440000.0 -0.81 1.003032E7 -1967434.0331492 -1.15522780268061 -1.2057 -0.851 3055039 HSCI1_000009 Cn1cnc2nc(NCCO)nc(NCc3ccccc3)c12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B16 compound treatment 9030360.0 -2250000.0 -1.26 9801960.0 -1210000.0 -0.68 1.0083E7 -1914754.0331492 -1.12429543106366 -1.7699 -0.9716 3175975 HSCI1_000010 CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1C(O)C(O)C(O)CC1OC)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B17 compound treatment 1.084104E7 -436000.0 -0.25 1.151056E7 502000.0 0.28 1.206996E7 72205.9668508004 0.04239752846603 0.0462 0.1226 3055043 HSCI1_000011 CCCCCCCCCCCCCCC[C@@H](O)[C@H](N)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B18 compound treatment 7506920.0 -3770000.0 -2.12 7188760.0 -3820000.0 -2.15 7410960.0 -4586794.0331492 -2.69325014358012 -4.019 -0.9936 2326 HSCI1_000012 CCCCCC(=O)O[C@@H]1[C@@H](OC(=O)/C(=C\C)/C)C(=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(=O)C)[C@@H]12)OC(=O)CCC)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B19 compound treatment 1.134728E7 69800.0 0.04 1.11378E7 130000.0 0.07 1.193768E7 -60074.0331491996 -0.03527396199507 0.0444 0.4929 2026 HSCI1_000013 CCCCCCCCCCNc1cc(CO)c2cc[nH]c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B20 compound treatment 334960.0 -1.09E7 -6.15 742680.0 -1.03E7 -5.78 501240.0 -1.14965140331492E7 -6.75046401619028 -10.7822 -0.9979 193 HSCI1_000014 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B21 compound treatment 7791080.0 -3490000.0 -1.96 6806520.0 -4200000.0 -2.37 7785000.0 -4212754.0331492 -2.47362325900142 -3.9243 -0.9952 3055048 HSCI1_000015 Nc1nc(Cl)nc2n(cnc12)C3OC(CO)[C@H](O)[C@H]3F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B22 compound treatment 5790800.0 -5490000.0 -3.08 5567160.0 -5440000.0 -3.06 6023480.0 -5974274.0331492 -3.50794351812629 -5.5729 -0.998 3175977 HSCI1_000016 CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@]41OC(=O)CCCCCCCCC)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B23 mock treatment 1.009548E7 -1180000.0 -0.66 9928520.0 -1080000.0 -0.61 1.06658E7 -1331954.0331492 -0.782089922742453 -1.1858 -0.9944 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 B24 mock treatment 8682440.0 -2600000.0 -1.46 9199080.0 -1810000.0 -1.02 9755560.0 -2242194.0331492 -1.31655996717329 -2.1896 -0.9897 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C01 mock treatment 1.078004E7 -497000.0 -0.28 1.087548E7 -133000.0 -0.07 1.080784E7 -1189914.0331492 -0.698687605649206 -0.6079 -0.8038 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C02 mock treatment 1.116236E7 -115000.0 -0.06 1.107676E7 68500.0 0.04 1.153112E7 -466634.0331492 -0.273995773016122 -0.1733 -0.6098 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C03 compound treatment 9557760.0 -1720000.0 -0.97 9177520.0 -1830000.0 -1.03 1.064156E7 -1356194.0331492 -0.796323041345243 -1.6124 -0.9944 2257 HSCI1_000017 COc1ccc(cc1)C(=O)CBr 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C04 compound treatment 7732600.0 -3540000.0 -1.99 1065520.0 -9940000.0 -5.6 8160800.0 -3836954.0331492 -2.25296294666939 -5.6817 -0.8943 561 HSCI1_000018 C[C@@H](NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C05 compound treatment 269120.0 -1.1E7 -6.18 3234040.0 -7770000.0 -4.38 1017280.0 -1.09804740331492E7 -6.44745830151273 -9.8189 -0.9871 2256 HSCI1_000019 Oc1ccc(cc1)C(=O)CBr 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C06 compound treatment 1.190936E7 632000.0 0.35 1.184732E7 839000.0 0.47 1.274796E7 750205.9668508 0.440502083445057 0.7319 0.9932 1000099 HSCI1_000020 C[C@H](NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C07 compound treatment 1.494224E7 3660000.0 2.06 1.027728E7 -731000.0 -0.41 1.4323E7 2325245.9668508 1.36532597470489 1.7391 0.6945 2258 HSCI1_000021 OC(=O)COc1ccc(cc1)C(=O)CBr 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C08 compound treatment 1.14952E7 218000.0 0.12 1.178352E7 775000.0 0.44 1.242304E7 425285.9668508 0.249717227982247 0.4667 0.902 2227 HSCI1_000022 CCCCCCCCCCCCCCCC(=O)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C09 compound treatment 1.223904E7 962000.0 0.54 1.168624E7 678000.0 0.38 1.250412E7 506365.9668508 0.297325365618972 0.7038 0.9707 2147 HSCI1_000023 CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(F)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C10 compound treatment 4627240.0 -6650000.0 -3.74 4153480.0 -6850000.0 -3.86 4558040.0 -7439714.0331492 -4.36841304474644 -6.9065 -0.9976 617 HSCI1_000024 COc1cc(OC)c(/C=C\2/C(=O)Nc3ccccc23)c(OC)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C11 mock treatment 1.20682E7 791000.0 0.44 1.160856E7 600000.0 0.34 1.245104E7 453285.9668508 0.266158124058077 0.6052 0.9788 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C12 mock treatment 1.208132E7 804000.0 0.45 1.223556E7 1230000.0 0.69 1.35194E7 1521645.9668508 0.893472257328569 1.1754 0.9663 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C13 mock treatment 1.242688E7 1150000.0 0.65 1.270336E7 1700000.0 0.95 1.28402E7 842445.9668508 0.49466309251772 1.2092 0.9645 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C14 mock treatment 1.164508E7 368000.0 0.21 1.217172E7 1160000.0 0.65 1.320416E7 1206405.9668508 0.708371254509117 0.9063 0.9186 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C15 mock treatment 1.176392E7 486000.0 0.27 1.182388E7 816000.0 0.46 1.27734E7 775645.9668508 0.455439811879669 0.6858 0.9768 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C16 mock treatment 1.181208E7 535000.0 0.3 1.152432E7 516000.0 0.29 1.251488E7 517125.9668508 0.303643367110969 0.5164 0.9998 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C17 compound treatment 1.10356E7 -242000.0 -0.14 1.062064E7 -388000.0 -0.22 1.177068E7 -227074.0331492 -0.133332163590199 -0.2814 -0.9718 3055108 HSCI1_000025 CSCC1OC([C@@H](O)[C@H]1O)n2ccc3c(N)ncnc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C18 compound treatment 1.26192E7 1340000.0 0.75 1.167612E7 668000.0 0.38 1.21006E7 102845.9668508 0.0603885661718669 0.687 0.8137 3055110 HSCI1_000026 ClCC(=O)c1cc(Br)c(Br)s1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C19 compound treatment 6425120.0 -4850000.0 -2.73 550320.0 -1.05E7 -5.89 322760.0 -1.16749940331492E7 -6.85526298517649 -8.9302 -0.9462 2121 HSCI1_000027 Oc1ccc(cc1)c2oc3cc(O)cc(O)c3c(=O)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C20 compound treatment 314960.0 -1.1E7 -6.16 181960.0 -1.08E7 -6.09 181280.0 -1.18164740331492E7 -6.93833648434823 -11.0794 -0.9982 1916983 HSCI1_000028 CC(C)C(N1C(=O)/C(=C/c2ccccc2)/SC1=S)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C21 compound treatment 1.090868E7 -369000.0 -0.21 1.080604E7 -202000.0 -0.11 1.205648E7 58725.9668508004 0.0344824113552375 -0.1654 -0.6925 2188 HSCI1_000029 Oc1ccc(O)c2C(=O)C(=C(Cl)C(=O)c12)Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C22 compound treatment 1.094776E7 -330000.0 -0.19 1.006584E7 -942000.0 -0.53 1.090184E7 -1095914.0331492 -0.643493168823206 -0.7847 -0.9186 563 HSCI1_000030 Oc1ccc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C23 compound treatment 1.115728E7 -120000.0 -0.07 1.020872E7 -800000.0 -0.45 1.1617E7 -380754.0331492 -0.223569196052112 -0.4279 -0.8439 1031143 HSCI1_000031 CS(=O)(=O)SCCN 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 C24 mock treatment 1.049316E7 -784000.0 -0.44 9724080.0 -1280000.0 -0.72 1.078276E7 -1214994.0331492 -0.713413951134271 -1.0836 -0.9788 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D01 mock treatment 1.016568E7 -1110000.0 -0.62 1.141752E7 409000.0 0.23 1.201528E7 17525.9668508004 0.0102908071293733 -0.2216 -0.3329 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D02 mock treatment 1.055148E7 -726000.0 -0.41 1.153596E7 528000.0 0.3 1.195784E7 -39914.0331491996 -0.0234365168204723 -0.0775 -0.1534 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D03 compound treatment 1.205624E7 779000.0 0.44 1.133968E7 331000.0 0.19 1.352128E7 1523525.9668508 0.894576146065089 0.8767 0.8654 551 HSCI1_000032 CC(C)(C)c1cc(C=C(C#N)C#N)cc(Br)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D04 compound treatment 5953680.0 -5320000.0 -2.99 5944400.0 -5060000.0 -2.85 7486240.0 -4511514.0331492 -2.64904762013053 -4.9016 -0.9988 3479696 HSCI1_000033 OC(=O)C(CCCCNC(=O)CNC(=O)c1cccc(c1)C(=O)NCC(=O)NCCCCC(NC(=O)OCc2ccc(cc2)C(F)(F)F)C(=O)O)NC(=O)OCc3ccc(cc3)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D05 compound treatment 9601400.0 -1680000.0 -0.94 7899720.0 -3110000.0 -1.75 9733920.0 -2263834.0331492 -1.32926643114047 -2.3213 -0.971 674 HSCI1_000034 CCOC(=O)c1c(C)[nH]c(/C=C/2\C(=O)Nc3ccccc23)c1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D06 compound treatment 1.142972E7 152000.0 0.09 1.034916E7 -659000.0 -0.37 1.20152E7 17445.9668508004 0.0102438331405852 -0.1589 -0.4173 146 HSCI1_000035 CCCCCC#CCC#CCC#CCC#CCCCC(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D07 compound treatment 1.178396E7 506000.0 0.28 1.081716E7 -191000.0 -0.11 1.163932E7 -358434.0331492 -0.210463453180236 -0.0194 -0.0524 3175981 HSCI1_000036 O=c1sn(Cc2ccccc2)c(=S)n1Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D08 compound treatment 7694320.0 -3580000.0 -2.01 6369040.0 -4640000.0 -2.61 1218680.0 -1.07790740331492E7 -6.32920128473872 -6.3239 -0.8861 1000097 HSCI1_000037 Cc1c(C)c2OC(C)(COc3ccc(CC4SC(=O)NC4=O)cc3)CCc2c(C)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D09 compound treatment 9837720.0 -1440000.0 -0.81 9090440.0 -1920000.0 -1.08 7540080.0 -4457674.0331492 -2.61743412567615 -2.6014 -0.8834 628 HSCI1_000038 Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc34)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D10 compound treatment 8733280.0 -2540000.0 -1.43 7585000.0 -3420000.0 -1.93 8417440.0 -3580314.0331492 -2.10227039063721 -3.1514 -0.9879 3175982 HSCI1_000039 COc1ccc(Nc2nccc(NCCO)n2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D11 mock treatment 1.186856E7 591000.0 0.33 1.23652E7 1360000.0 0.76 1.285804E7 860285.9668508 0.505138292017464 0.9243 0.9489 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D12 mock treatment 1.261752E7 1340000.0 0.75 1.205944E7 1050000.0 0.59 1.374376E7 1746005.9668508 1.02521080888476 1.3681 0.9753 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D13 mock treatment 1.302692E7 1750000.0 0.98 1.203396E7 1030000.0 0.58 1.318812E7 1190365.9668508 0.698952969757106 1.3042 0.9755 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D14 mock treatment 1.404072E7 2760000.0 1.55 1.184552E7 837000.0 0.47 1.30054E7 1007645.9668508 0.591664379365118 1.5098 0.8744 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D15 mock treatment 1.17E7 422000.0 0.24 1.182592E7 818000.0 0.46 1.252908E7 531325.9668508 0.311981250120855 0.5829 0.9641 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D16 mock treatment 1.168456E7 407000.0 0.23 1.140672E7 398000.0 0.22 1.258336E7 585605.9668508 0.343853101513571 0.46 0.979 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D17 compound treatment 1.18456E7 568000.0 0.32 1.154184E7 534000.0 0.3 1.268808E7 690325.9668508 0.405342052837175 0.5917 0.9912 584 HSCI1_000040 Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D18 compound treatment 1.127224E7 -5290.0 0.0 9579240.0 -1430000.0 -0.8 1.042536E7 -1572394.0331492 -0.923270246045045 -0.9992 -0.816 2180 HSCI1_000041 COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c4ncn(C(C)C)c4n2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D19 compound treatment 1.265164E7 1370000.0 0.77 1.17528E7 745000.0 0.42 1.271132E7 713565.9668508 0.418987996580114 0.9295 0.9552 3055161 HSCI1_000042 COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D20 compound treatment 1.135452E7 77000.0 0.04 1.066172E7 -347000.0 -0.2 1.110848E7 -889274.0331492 -0.52215935578358 -0.3891 -0.696 2067 HSCI1_000043 CC(C)C(C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1)c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D21 compound treatment 1.076812E7 -509000.0 -0.29 9996840.0 -1010000.0 -0.57 1.051336E7 -1484394.0331492 -0.87159885837815 -0.9971 -0.9235 3055164 HSCI1_000044 N/C(=C(/C#N)\c1ccccc1C(F)(F)F)/Sc2ccc(N)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D22 compound treatment 9625200.0 -1650000.0 -0.93 1.123392E7 226000.0 0.13 1.160908E7 -388674.0331492 -0.228219620942133 -0.5942 -0.6164 2407 HSCI1_000045 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ncc(C)s3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D23 compound treatment 4230920.0 -7050000.0 -3.96 1800040.0 -9210000.0 -5.18 1843280.0 -1.01544740331492E7 -5.96245186727574 -8.7202 -0.9868 550 HSCI1_000046 COC1=C(Br)[C@H](O)[C@](O)(CC#N)C=C1Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 D24 mock treatment 1.030168E7 -976000.0 -0.55 1.000908E7 -999000.0 -0.56 1.064904E7 -1348714.0331492 -0.791930973393557 -1.0984 -0.9848 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E01 mock treatment 1.087388E7 -404000.0 -0.23 1.04622E7 -546000.0 -0.31 1.120576E7 -791994.0331492 -0.465038985417267 -0.5769 -0.9586 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E02 mock treatment 1.130716E7 29600.0 0.02 1.173308E7 725000.0 0.41 1.15752E7 -422554.0331492 -0.248113105193887 0.1019 0.2133 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E03 mock treatment 1.10916E7 -186000.0 -0.1 1.145896E7 451000.0 0.25 1.220312E7 205365.9668508 0.120585732803799 0.1558 0.5199 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E04 mock treatment 1.18166E7 539000.0 0.3 1.138936E7 381000.0 0.21 1.255804E7 560285.9668508 0.328985834062142 0.4886 0.9853 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E05 compound treatment 7993760.0 -3280000.0 -1.84 8106920.0 -2900000.0 -1.63 1.095752E7 -1040234.0331492 -0.610799272626698 -2.3604 -0.93 2294 HSCI1_000047 CC(=O)NC(C(=O)O)C(C)(C)SN=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E06 compound treatment 1.118516E7 -92400.0 -0.05 1.085512E7 -153000.0 -0.09 1.234412E7 346365.9668508 0.2033773880428 0.0377 0.1662 3175983 HSCI1_000048 CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCC/C=C/C/C=C/C\C=C\C\C=C\CCCCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E07 compound treatment 1.154252E7 265000.0 0.15 1.118684E7 179000.0 0.1 1.24106E7 412845.9668508 0.2424127727257 0.2839 0.9411 640 HSCI1_000049 O=C/1Nc2ccccc2\C1=C\c3ccc[nH]3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E08 compound treatment 1.229696E7 1020000.0 0.57 1.185652E7 848000.0 0.48 1.299724E7 999485.9668508 0.586873032508733 0.9451 0.9961 1907779 HSCI1_000050 CC(C)n1cnc2c(NCc3ccccc3)nc(NCCO)nc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E09 mock treatment 1.18268E7 549000.0 0.31 1.162564E7 617000.0 0.35 1.317648E7 1178725.9668508 0.692118254388439 0.7784 0.9337 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E10 mock treatment 1.19302E7 653000.0 0.37 1.150164E7 493000.0 0.28 1.268396E7 686205.9668508 0.402922892414589 0.6046 0.9888 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E11 compound treatment 1.213916E7 862000.0 0.48 1.09692E7 -39000.0 -0.02 1.244412E7 446365.9668508 0.262094874027907 0.418 0.759 627 HSCI1_000051 C=CC(=O)c1ccc2ccccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E12 compound treatment 6577160.0 -4700000.0 -2.64 7304280.0 -3700000.0 -2.09 7743160.0 -4254594.0331492 -2.49819065513759 -4.1704 -0.9953 536 HSCI1_000052 ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E13 compound treatment 1.237844E7 1100000.0 0.62 1.296772E7 1960000.0 1.1 1.320644E7 1208685.9668508 0.709710013189577 1.4036 0.9679 593 HSCI1_000053 Oc1ccc2ccc(=O)oc2c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E14 compound treatment 7716400.0 -3560000.0 -2.0 6757080.0 -4250000.0 -2.39 7527320.0 -4470434.0331492 -2.62492647688785 -4.0519 -0.994 3055208 HSCI1_000054 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E15 mock treatment 1.212536E7 848000.0 0.48 1.16472E7 639000.0 0.36 1.25392E7 541445.9668508 0.317923459702547 0.6662 0.9852 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E16 mock treatment 1.184716E7 570000.0 0.32 1.207844E7 1070000.0 0.6 1.252216E7 524405.9668508 0.307918000090685 0.7103 0.9491 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E17 mock treatment 1.14414E7 164000.0 0.09 1.112912E7 121000.0 0.07 1.187044E7 -127314.0331492 -0.0747555995714561 0.0493 0.3604 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E18 mock treatment 1.153452E7 257000.0 0.14 1.1192E7 184000.0 0.1 1.229996E7 302205.9668508 0.177447746231777 0.2455 0.9779 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E19 compound treatment 1.138232E7 105000.0 0.06 1.140692E7 399000.0 0.22 1.180052E7 -197234.0331492 -0.115810865772243 0.0967 0.3729 1912 HSCI1_000055 [O-][N+](=O)c1cccc2cn[nH]c12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E20 compound treatment 1.176068E7 483000.0 0.27 1.165828E7 650000.0 0.37 1.29386E7 940845.9668508 0.552441098727066 0.6869 0.9593 3175984 HSCI1_000056 CCCC(=O)OCSC(=S)OC1CC2CC1C3CCCC23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E21 compound treatment 1.090404E7 -373000.0 -0.21 9493120.0 -1520000.0 -0.85 1.097416E7 -1023594.0331492 -0.601028682958776 -0.9605 -0.9025 596 HSCI1_000057 CN(C)c1ccc(/C=C\2/C(=O)Nc3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E22 compound treatment 2377400.0 -8900000.0 -5.0 2613640.0 -8390000.0 -4.73 2159600.0 -9838154.0331492 -5.77671671560765 -8.9496 -0.9963 564 HSCI1_000058 Oc1ccc(/C=C(\C#N)/C(=O)NCCCCc2ccccc2)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E23 compound treatment 1.140764E7 130000.0 0.07 1.030504E7 -703000.0 -0.4 1.130412E7 -693634.0331492 -0.407284466202316 -0.4215 -0.7361 2175 HSCI1_000059 CCCCCCCCN1C(=O)C(=C(C)C1(C)O)C(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 E24 mock treatment 1.0659E7 -619000.0 -0.35 1.010996E7 -898000.0 -0.51 1.139516E7 -602594.0331492 -0.353828066961474 -0.6968 -0.9839 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F01 mock treatment 1.040968E7 -868000.0 -0.49 1.096384E7 -44400.0 -0.02 1.12686E7 -729154.0331492 -0.428140917224226 -0.5431 -0.8364 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F02 mock treatment 1.027424E7 -1000000.0 -0.56 1.126616E7 258000.0 0.15 1.200948E7 11725.9668508004 0.00688519294223708 -0.2376 -0.4082 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F03 mock treatment 1.059096E7 -687000.0 -0.39 1.136348E7 355000.0 0.2 1.20348E7 37045.9668508004 0.0217524603936662 -0.0946 -0.2176 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F04 mock treatment 1.120584E7 -71700.0 -0.04 1.046904E7 -539000.0 -0.3 1.227732E7 279565.9668508 0.164154107404748 -0.1037 -0.2985 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F05 compound treatment 1.044728E7 -830000.0 -0.47 1.119284E7 185000.0 0.1 1.172904E7 -268714.0331492 -0.157782124754398 -0.3003 -0.5969 2108 HSCI1_000060 COc1cc2C/C(=C\c3cc(C)c(O)c(C)c3)/C(=O)c2c(N)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F06 compound treatment 1.101024E7 -267000.0 -0.15 9390000.0 -1620000.0 -0.91 1.185852E7 -139234.0331492 -0.0817547239008809 -0.6598 -0.7119 2303 HSCI1_000061 COc1cc2CCN3Cc4c(OC)c(O)ccc4CC3c2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F07 compound treatment 7244680.0 -4030000.0 -2.27 6864440.0 -4140000.0 -2.33 6777320.0 -5220434.0331492 -3.06530762177615 -4.4243 -0.9901 1967 HSCI1_000062 Brc1cccc(Nc2ncnc3cc4[nH]cnc4cc23)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F08 compound treatment 1.175528E7 478000.0 0.27 1.154288E7 535000.0 0.3 1.257604E7 578285.9668508 0.339554981539461 0.5247 0.9954 1918768 HSCI1_000063 Clc1ccc(C(=O)n2nnc3ccccc23)c(Cl)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F09 mock treatment 1.13118E7 34300.0 0.02 1.147652E7 468000.0 0.26 1.247136E7 473605.9668508 0.278089517210251 0.3239 0.8441 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F10 mock treatment 1.29896E7 1710000.0 0.96 1.179072E7 782000.0 0.44 1.31734E7 1175645.9668508 0.690309755820098 1.2081 0.9565 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F11 compound treatment 1.004288E7 -1230000.0 -0.69 8109800.0 -2900000.0 -1.63 8304120.0 -3693634.0331492 -2.16880904575553 -2.5945 -0.9262 583 HSCI1_000064 CC(C)n1cnc2c(NCc3ccccc3)nc(NCCCO)nc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F12 compound treatment 1.181624E7 539000.0 0.3 1.078304E7 -225000.0 -0.13 1.146688E7 -530874.0331492 -0.311715886012955 -0.0785 -0.1734 1085933 HSCI1_000065 COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F13 compound treatment 9194200.0 -2080000.0 -1.17 8058160.0 -2950000.0 -1.66 8241680.0 -3756074.0331492 -2.20547224400464 -2.9077 -0.9697 675 HSCI1_000066 Brc1ccc2NC(=O)/C(=C\c3cc4CCCCc4[nH]3)/c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F14 compound treatment 1.197624E7 699000.0 0.39 1.052136E7 -487000.0 -0.27 1.09772E7 -1020554.0331492 -0.599243671384829 -0.2776 -0.362 2144 HSCI1_000067 O=C(Nc1ccccc1)C2C(=O)NC(=S)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F15 mock treatment 1.19844E7 707000.0 0.4 1.132708E7 319000.0 0.18 1.24668E7 469045.9668508 0.27541199984933 0.4919 0.9542 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F16 mock treatment 1.227736E7 1000000.0 0.56 1.162736E7 619000.0 0.35 1.290412E7 906365.9668508 0.532195309559401 0.8327 0.9813 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F17 mock treatment 1.221044E7 933000.0 0.52 1.12738E7 266000.0 0.15 1.256556E7 567805.9668508 0.333401389008222 0.5813 0.91 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F18 mock treatment 1.197848E7 701000.0 0.39 1.150204E7 494000.0 0.28 1.267476E7 677005.9668508 0.397520883703959 0.6173 0.9881 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F19 compound treatment 1.147616E7 199000.0 0.11 1.01492E7 -859000.0 -0.48 1.149172E7 -506034.0331492 -0.297130462494255 -0.3863 -0.6679 643 HSCI1_000068 CNc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F20 compound treatment 1.081496E7 -463000.0 -0.26 1.014536E7 -863000.0 -0.49 1.113532E7 -862434.0331492 -0.506399582545177 -0.7228 -0.966 122 HSCI1_000069 C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F21 compound treatment 1.03752E7 -902000.0 -0.51 9122600.0 -1890000.0 -1.06 9990400.0 -2007354.0331492 -1.17866782308587 -1.5859 -0.9524 590 HSCI1_000070 CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F22 compound treatment 9957760.0 -1320000.0 -0.74 7175840.0 -3830000.0 -2.16 7621240.0 -4376514.0331492 -2.56977901405064 -3.1572 -0.9188 2060831 HSCI1_000071 O=C1CCCC(=O)C1CC2C(=O)CCCC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F23 compound treatment 1.078212E7 -495000.0 -0.28 9736360.0 -1270000.0 -0.72 1.022952E7 -1768234.0331492 -1.03826257059828 -1.1735 -0.9086 3176054 HSCI1_000072 N/C(=C(/C#N)\C(=C(/N)\Sc1ccccc1)\[N+]#[C-])/Sc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 F24 mock treatment 9567400.0 -1710000.0 -0.96 9928200.0 -1080000.0 -0.61 1.047008E7 -1527674.0331492 -0.897011786312505 -1.4235 -0.983 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G01 mock treatment 1.09848E7 -293000.0 -0.16 1.126504E7 257000.0 0.14 1.132772E7 -670034.0331492 -0.39342713950983 -0.2386 -0.53 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G02 compound treatment 7727840.0 -3550000.0 -1.99 7384160.0 -3620000.0 -2.04 7849200.0 -4148554.0331492 -2.43592663299899 -3.7353 -0.9958 305 HSCI1_000073 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G03 mock treatment 1.080068E7 -477000.0 -0.27 1.15686E7 560000.0 0.32 1.175128E7 -246474.0331492 -0.14472335587131 -0.0561 -0.1279 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G04 mock treatment 1.169208E7 415000.0 0.23 1.14008E7 393000.0 0.22 1.262484E7 627085.9668508 0.368209114700193 0.4746 0.9716 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G05 mock treatment 1.060912E7 -668000.0 -0.38 1.16724E7 664000.0 0.37 1.210828E7 110525.9668508 0.0648980690955231 0.0366 0.0685 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G06 mock treatment 1.27202E7 1440000.0 0.81 1.146276E7 455000.0 0.26 1.347048E7 1472725.9668508 0.864747663184655 1.1148 0.9195 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G07 compound treatment 1.348808E7 2210000.0 1.24 1.176316E7 755000.0 0.42 1.419524E7 2197485.9668508 1.29030851461032 1.7072 0.9276 2073 HSCI1_000074 CC(=CCC/C(=C/CC/C(=C/CSc1nc[nH]n1)/C)/C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G08 compound treatment 7002120.0 -4280000.0 -2.4 7191000.0 -3820000.0 -2.15 7355760.0 -4641994.0331492 -2.7256621958439 -4.2007 -0.9953 3176055 HSCI1_000075 CCOc1cc(/C=C(/C#N)\C(=O)N)cc(CSc2ccccc2)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G09 compound treatment 1.068124E7 -596000.0 -0.33 1.092388E7 -84400.0 -0.05 1.138576E7 -611994.0331492 -0.359347510644074 -0.4283 -0.8678 2335 HSCI1_000076 COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G10 compound treatment 1.13522E7 74700.0 0.04 9613200.0 -1400000.0 -0.79 9160280.0 -2837474.0331492 -1.66609341774544 -1.3911 -0.7551 3055275 HSCI1_000077 CC(C)(C)OC(=O)NC(CC(=O)CCl)C(=O)Cc1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G11 compound treatment 9663640.0 -1610000.0 -0.91 9226360.0 -1780000.0 -1.0 1.081296E7 -1184794.0331492 -0.695681270366769 -1.5041 -0.9893 2134 HSCI1_000078 COc1cc(O)c(cc1/C=C/C(=O)c2ccc(O)cc2)C(C)(C)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G12 compound treatment 1.147316E7 196000.0 0.11 1.097112E7 -37100.0 -0.02 1.259256E7 594805.9668508 0.349255110224201 0.253 0.6899 3055277 HSCI1_000079 COc1cc(cc(CN(C)CCc2ccc(cc2)[N+](=O)[O-])c1O)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G13 compound treatment 4285120.0 -6990000.0 -3.93 4829760.0 -6180000.0 -3.48 5427640.0 -6570114.0331492 -3.85780578661995 -6.5028 -0.9986 1002387 HSCI1_000080 Oc1ccc(C=C(C#N)C#N)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G14 compound treatment 1.10772E7 -200000.0 -0.11 7974000.0 -3030000.0 -1.71 8035520.0 -3962234.0331492 -2.32652421311153 -2.3943 -0.8289 3176058 HSCI1_000081 C[C@@H]1[C@@H](O)[C@@]2(O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@]13O)C2(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G15 compound treatment 369520.0 -1.09E7 -6.13 298040.0 -1.07E7 -6.03 342400.0 -1.16553540331492E7 -6.84373087092902 -10.9693 -0.9984 672 HSCI1_000082 Oc1ccc(CC(C#N)C#N)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G16 compound treatment 1.20702E7 793000.0 0.45 1.118E7 172000.0 0.1 1.287236E7 874605.9668508 0.513546636010531 0.6094 0.8876 3176059 HSCI1_000083 OCc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G17 mock treatment 1.239956E7 1120000.0 0.63 1.114228E7 134000.0 0.08 1.354212E7 1544365.9668508 0.906812870144386 0.931 0.8411 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G18 mock treatment 1.195708E7 680000.0 0.38 1.119548E7 187000.0 0.11 1.264964E7 651885.9668508 0.3827710512245 0.5022 0.9119 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G19 mock treatment 1.229004E7 1010000.0 0.57 1.101332E7 5070.0 0.0 1.2476E7 478245.9668508 0.28081400855996 0.4921 0.7759 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G20 mock treatment 1.218084E7 903000.0 0.51 1.117292E7 165000.0 0.09 1.271348E7 715725.9668508 0.420256294277392 0.5891 0.8854 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G21 compound treatment 1.19898E7 712000.0 0.4 1.10474E7 39200.0 0.02 1.211004E7 112285.9668508 0.065931496848861 0.2818 0.6939 3415700 HSCI1_000084 CCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G22 compound treatment 1.254492E7 1270000.0 0.71 1.079484E7 -213000.0 -0.12 1.074652E7 -1251234.0331492 -0.734693168055274 -0.0825 -0.0801 3176060 HSCI1_000085 CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]4CCCC[C@@H]4N)nc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G23 compound treatment 1.017172E7 -1110000.0 -0.62 8912960.0 -2100000.0 -1.18 1.0024E7 -1973754.0331492 -1.15893874779487 -1.7087 -0.9673 3055326 HSCI1_000086 Cc1ccc(cc1)c2cn3c4CCCCc4sc3n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 G24 mock treatment 1.153936E7 262000.0 0.15 1.031608E7 -692000.0 -0.39 1.177352E7 -224234.0331492 -0.131664586988222 -0.2161 -0.4947 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H01 mock treatment 1.113428E7 -143000.0 -0.08 1.14606E7 452000.0 0.25 1.140208E7 -595674.0331492 -0.349764816931305 -0.1014 -0.2304 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H02 compound treatment 8957320.0 -2320000.0 -1.3 8576640.0 -2430000.0 -1.37 9245960.0 -2751794.0331492 -1.6157842757534 -2.4756 -0.9956 1886 HSCI1_000087 NCCOB(c1ccccc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H03 mock treatment 1.152692E7 249000.0 0.14 1.122588E7 218000.0 0.12 1.202656E7 28805.9668508004 0.0169141395484934 0.1614 0.8636 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H04 mock treatment 1.203744E7 760000.0 0.43 1.085016E7 -158000.0 -0.09 1.259564E7 597885.9668508 0.351063608792542 0.3977 0.7105 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H05 mock treatment 1.148776E7 210000.0 0.12 1.156168E7 553000.0 0.31 1.245688E7 459125.9668508 0.269587225239607 0.4037 0.9419 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H06 mock treatment 1.152936E7 252000.0 0.14 1.2056E7 1050000.0 0.59 1.216688E7 169125.9668508 0.099306515882796 0.4795 0.7802 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H07 compound treatment 1.165828E7 381000.0 0.21 1.216268E7 1150000.0 0.65 1.23028E7 305045.9668508 0.179115322833754 0.6021 0.8514 2278 HSCI1_000088 Oc1cc(ccc1NC(=O)Nc2ccccc2Br)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H08 compound treatment 6888080.0 -4390000.0 -2.47 8151080.0 -2860000.0 -1.61 9458400.0 -2539354.0331492 -1.49104484852664 -3.2129 -0.9737 1891 HSCI1_000089 Clc1oc(=O)c2ccccc2c1Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H09 compound treatment 1.186284E7 585000.0 0.33 1.135728E7 349000.0 0.2 1.25348E7 537045.9668508 0.315339890319203 0.4853 0.9782 1966 HSCI1_000090 Cn1cnc2cc3c(Nc4cccc(Br)c4)ncnc3cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H10 compound treatment 1.257628E7 1300000.0 0.73 1.159368E7 585000.0 0.33 1.292416E7 926405.9668508 0.543962293750817 0.9255 0.9563 3176061 HSCI1_000091 CC1(CCC2(C)O1)C(C2C(=O)O)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H11 compound treatment 8217360.0 -3060000.0 -1.72 9455840.0 -1550000.0 -0.87 8092480.0 -3905274.0331492 -2.29307873309442 -2.8208 -0.9415 291 HSCI1_000092 CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H12 compound treatment 1.012024E7 -1160000.0 -0.65 8364080.0 -2640000.0 -1.49 8624640.0 -3373114.0331492 -1.98060775967607 -2.3781 -0.9285 3055333 HSCI1_000093 O=C/1Nc2ccccc2\C1=C/c3c[nH]cn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H13 compound treatment 1.24906E7 1210000.0 0.68 1.046584E7 -542000.0 -0.31 1.198176E7 -15994.0331491996 -0.00939129417283467 0.2117 0.2835 3176062 HSCI1_000094 CC[C@@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H14 compound treatment 1.177636E7 499000.0 0.28 1.259632E7 1590000.0 0.89 1.152632E7 -471434.0331492 -0.276814212343407 0.5181 0.5303 1040138 HSCI1_000095 COc1cc(C=O)c(cc1OC)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H15 compound treatment 1.324412E7 1970000.0 1.1 1.219052E7 1180000.0 0.67 1.370432E7 1706565.9668508 1.00205263241223 1.6005 0.98 3176063 HSCI1_000096 CC(C)n1cnc2c(NCc3ccccc3O)nc(NCCCO)nc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H16 compound treatment 1.092308E7 -354000.0 -0.2 4923920.0 -6080000.0 -3.42 2821920.0 -9175834.0331492 -5.38781906243109 -5.203 -0.8146 2109 HSCI1_000097 OCc1c[nH]c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H17 mock treatment 1.195092E7 673000.0 0.38 1.130608E7 298000.0 0.17 1.220164E7 203885.9668508 0.119716714011219 0.3843 0.8922 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H18 mock treatment 1.223744E7 960000.0 0.54 1.189756E7 889000.0 0.5 1.30854E7 1087645.9668508 0.638638368153204 0.969 0.9946 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H19 mock treatment 1.173896E7 461000.0 0.26 1.081772E7 -191000.0 -0.11 1.31384E7 1140645.9668508 0.66975863572531 0.4744 0.6533 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H20 mock treatment 1.30096E7 1730000.0 0.97 1.102536E7 17100.0 0.01 1.32506E7 1252845.9668508 0.735639655000601 0.992 0.8133 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H21 compound treatment 5131480.0 -6150000.0 -3.45 330920.0 -1.07E7 -6.01 423440.0 -1.15743140331492E7 -6.79614622028669 -9.3869 -0.967 3176064 HSCI1_000098 O/N=C\1/C(=C\2/C(=O)Nc3ccc(cc23)S(=O)(=O)O)/Nc4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H22 compound treatment 1.071252E7 -565000.0 -0.32 9660480.0 -1350000.0 -0.76 1.075388E7 -1243874.0331492 -0.73037156108677 -1.0429 -0.9482 2069332 HSCI1_000099 CC(=O)/C(=N/O)/C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H23 compound treatment 1.110696E7 -171000.0 -0.1 9873680.0 -1130000.0 -0.64 1.099656E7 -1001194.0331492 -0.587875966098112 -0.7635 -0.8742 642 HSCI1_000100 COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 H24 mock treatment 1.14212E7 144000.0 0.08 1.011892E7 -889000.0 -0.5 1.137384E7 -623914.0331492 -0.366346634973499 -0.4539 -0.7257 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I01 mock treatment 9726440.0 -1550000.0 -0.87 1.051036E7 -498000.0 -0.28 1.167092E7 -326834.0331492 -0.191908727608942 -0.7756 -0.8294 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I02 compound treatment 1.021536E7 -1060000.0 -0.6 1.06164E7 -392000.0 -0.22 1.119648E7 -801274.0331492 -0.470487968116685 -0.7434 -0.9397 666 HSCI1_000101 CC(C)c1cc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc(C(C)C)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I03 compound treatment 1.080024E7 -477000.0 -0.27 1.036524E7 -643000.0 -0.36 1.170504E7 -292714.0331492 -0.171874321390824 -0.463 -0.9603 3176066 HSCI1_000102 CCCCC/C=C/C/C=C/C\C=C\C\C=C\CCCC(=O)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I04 compound treatment 9972160.0 -1310000.0 -0.73 9664600.0 -1340000.0 -0.76 9866800.0 -2130954.0331492 -1.25124263576346 -1.5824 -0.9675 2104844 HSCI1_000103 Oc1ccc(O)c(CNc2ccc(cc2)C(=O)OC3(CC4CC5CC(C4)C3)C5)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I05 mock treatment 9972680.0 -1300000.0 -0.73 1.097284E7 -35400.0 -0.02 1.16906E7 -307154.0331492 -0.180353126367073 -0.5388 -0.7136 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I06 mock treatment 1.169208E7 415000.0 0.23 1.302712E7 2020000.0 1.14 1.239632E7 398565.9668508 0.234027915727026 0.9257 0.7822 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I07 mock treatment 1.194944E7 672000.0 0.38 1.14222E7 414000.0 0.23 1.237184E7 374085.9668508 0.219653875157872 0.4792 0.9683 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I08 mock treatment 1.164116E7 364000.0 0.2 1.161028E7 602000.0 0.34 1.275328E7 755525.9668508 0.443625853699465 0.5697 0.9584 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I09 compound treatment 1.183684E7 559000.0 0.31 1.166024E7 652000.0 0.37 1.233812E7 340365.9668508 0.199854338883694 0.5087 0.9729 626 HSCI1_000104 CC(C)N(CCC(=O)c1ccc2ccccc2c1)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I10 compound treatment 1.18214E7 544000.0 0.31 1.210112E7 1090000.0 0.62 1.259124E7 593485.9668508 0.348480039409197 0.7327 0.9514 3055340 HSCI1_000105 Cc1ccc(N/N=C/2\C(=O)Nc3ccc(Br)cc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I11 compound treatment 1.121488E7 -62600.0 -0.04 1.192588E7 918000.0 0.52 1.212172E7 123965.9668508 0.0727896992119215 0.3199 0.6119 568 HSCI1_000106 COc1ccc(C=C(C#N)C#N)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I12 compound treatment 1.040032E7 -877000.0 -0.49 1.052344E7 -485000.0 -0.27 1.105856E7 -939194.0331492 -0.551471124787345 -0.7604 -0.9647 3176067 HSCI1_000107 Ic1cccc(CSc2nnc(o2)c3ccncc3)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I13 compound treatment 1.39514E7 2670000.0 1.5 1.31274E7 2120000.0 1.19 1.305904E7 1061285.9668508 0.623160438847529 1.9156 0.9499 558 HSCI1_000108 Oc1ccc(C=C(C#N)C#N)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I14 compound treatment 1.056504E7 -712000.0 -0.4 1.094096E7 -67300.0 -0.04 1.12882E7 -709554.0331492 -0.416632289971145 -0.4935 -0.8524 3176068 HSCI1_000109 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)CCCCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I15 compound treatment 1.202708E7 750000.0 0.42 1.103192E7 23700.0 0.01 1.281168E7 813925.9668508 0.477916865514768 0.5267 0.8268 1975 HSCI1_000110 C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)CC[C@@H]1c5ccc(=O)oc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I16 compound treatment 1.134604E7 68500.0 0.04 1.057736E7 -431000.0 -0.24 1.028944E7 -1708314.0331492 -1.003079052996 -0.6969 -0.6749 1001980 HSCI1_000111 CCCCCCCC/C=C/CCCCCCCC(=O)OCC(CO)OC(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I17 compound treatment 9471440.0 -1810000.0 -1.01 2765040.0 -8240000.0 -4.64 2087360.0 -9910394.0331492 -5.81913422748329 -6.6244 -0.8819 130 HSCI1_000112 C/C(=C\C=C\C(=C\C(=O)Nc1ccc(O)cc1)\C)/C=C/C2=C(C)CCCC2(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I18 compound treatment 6808840.0 -4470000.0 -2.51 5571480.0 -5440000.0 -3.06 6279960.0 -5717794.0331492 -3.35734491007168 -5.1544 -0.9931 1922639 HSCI1_000113 CC(C)C(N1C(=O)/C(=C/c2ccc(Br)cc2)/SC1=S)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I19 mock treatment 1.167672E7 399000.0 0.22 1.124528E7 237000.0 0.13 1.240056E7 402805.9668508 0.236517537132795 0.343 0.9741 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I20 mock treatment 1.152484E7 247000.0 0.14 1.230052E7 1290000.0 0.73 1.216608E7 168325.9668508 0.0988367759949151 0.5572 0.7458 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I21 mock treatment 1.119456E7 -83000.0 -0.05 1.046356E7 -545000.0 -0.31 1.189788E7 -99874.0331491996 -0.0586435214171427 -0.2378 -0.7534 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I22 mock treatment 1.111952E7 -158000.0 -0.09 1.029416E7 -714000.0 -0.4 1.230084E7 303085.9668508 0.177964460108446 -0.1806 -0.4026 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I23 compound treatment 1.09796E7 -298000.0 -0.17 1.017556E7 -833000.0 -0.47 1.089836E7 -1099394.0331492 -0.645536537335487 -0.7399 -0.9078 565 HSCI1_000114 Oc1cc(C=C(C#N)C#N)cc(O)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 I24 mock treatment 1.081608E7 -461000.0 -0.26 9804640.0 -1200000.0 -0.68 1.055752E7 -1440234.0331492 -0.845669216567127 -1.0291 -0.9236 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J01 mock treatment 1.033092E7 -947000.0 -0.53 1.14202E7 412000.0 0.23 1.039848E7 -1599274.0331492 -0.939053506277842 -0.7153 -0.648 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J02 compound treatment 8606120.0 -2670000.0 -1.5 8893760.0 -2110000.0 -1.19 9266200.0 -2731554.0331492 -1.60389985659001 -2.4795 -0.9925 3176070 HSCI1_000115 OC(=O)c1c(Br)c(Br)c(Br)c(Br)c1c2c3ccc(O)cc3oc4cc(=O)ccc24 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J03 compound treatment 443240.0 -1.08E7 -6.09 433160.0 -1.06E7 -5.95 684600.0 -1.13131540331492E7 -6.64279963388798 -10.7855 -0.9988 294 HSCI1_000116 [O-][N+](=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J04 compound treatment 1.108968E7 -188000.0 -0.11 1.029376E7 -714000.0 -0.4 1.170952E7 -288234.0331492 -0.169243778018691 -0.3908 -0.8706 3055387 HSCI1_000117 C[C@@]12CCC3C(CCC4=C[C@H](O)CCC34)C2CC[C@@H]1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J05 mock treatment 1.170224E7 425000.0 0.24 1.083464E7 -174000.0 -0.1 1.192768E7 -70074.0331491996 -0.0411457105935807 0.0576 0.2205 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J06 mock treatment 1.166848E7 391000.0 0.22 1.132304E7 315000.0 0.18 1.280228E7 804525.9668508 0.472397421832168 0.5018 0.912 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J07 mock treatment 1.174108E7 464000.0 0.26 1.102716E7 18900.0 0.01 1.211048E7 112725.9668508 0.0661898537871955 0.1947 0.7241 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J08 mock treatment 1.18172E7 540000.0 0.3 1.124784E7 240000.0 0.13 1.221324E7 215485.9668508 0.126527942385492 0.3259 0.9179 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J09 compound treatment 1.115524E7 -122000.0 -0.07 1.053044E7 -478000.0 -0.27 1.055668E7 -1441074.0331492 -0.846162443449402 -0.6835 -0.7675 633 HSCI1_000118 OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3ccccc3O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J10 compound treatment 1.218752E7 910000.0 0.51 1.121564E7 207000.0 0.12 1.26358E7 638045.9668508 0.374644551164161 0.5788 0.8982 2251 HSCI1_000119 O=C(NC1=CC(=O)c2ccccc2C1=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J11 compound treatment 1.225112E7 974000.0 0.55 1.125408E7 246000.0 0.14 1.285932E7 861565.9668508 0.505889875838073 0.6877 0.9076 645 HSCI1_000120 Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J12 compound treatment 1.172468E7 447000.0 0.25 1.190752E7 899000.0 0.51 1.188548E7 -112274.0331492 -0.065924489679296 0.3992 0.7017 3176071 HSCI1_000121 Nc1nc(Cl)nc2n(cnc12)C3C[C@@H](O)C(CO)O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J13 compound treatment 1.350704E7 2230000.0 1.25 1.13816E7 373000.0 0.21 1.290496E7 907205.9668508 0.532688536441676 1.1519 0.8365 646 HSCI1_000122 CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J14 compound treatment 1.123408E7 -43400.0 -0.02 1.003728E7 -971000.0 -0.55 1.04698E7 -1527954.0331492 -0.897176195273263 -0.8476 -0.8066 854065 HSCI1_000123 CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J15 compound treatment 9409080.0 -1870000.0 -1.05 7528640.0 -3480000.0 -1.96 7262720.0 -4735034.0331492 -2.78029294480444 -3.342 -0.939 670 HSCI1_000124 CN(C)S(=O)(=O)c1ccc2NC(=O)/C(=C\c3cc4CCCCc4[nH]3)/c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J16 compound treatment 1.18572E7 580000.0 0.33 1.163448E7 626000.0 0.35 1.18088E7 -188954.0331492 -0.110949057932676 0.3274 0.6648 3176072 HSCI1_000125 CN(C)c1ccc(/C=C/2\C(=O)Nc3ccccc23)c4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J17 compound treatment 1.168772E7 410000.0 0.23 1.03346E7 -674000.0 -0.38 1.137904E7 -618714.0331492 -0.363293325702273 -0.2957 -0.5156 1996 HSCI1_000126 CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J18 compound treatment 1.223676E7 959000.0 0.54 1.023804E7 -770000.0 -0.43 1.192856E7 -69194.0331491996 -0.0406289967169118 0.0373 0.0538 2268 HSCI1_000127 CC(=CC1C(C(=O)OCc2coc(Cc3ccccc3)c2)C1(C)C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J19 mock treatment 1.243776E7 1160000.0 0.65 1.173492E7 727000.0 0.41 1.28782E7 880445.9668508 0.516975737192061 0.9109 0.9827 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J20 mock treatment 1.149932E7 222000.0 0.12 1.085792E7 -150000.0 -0.08 1.208148E7 83725.9668508004 0.0491617828515143 0.0515 0.3248 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J21 mock treatment 1.125072E7 -26800.0 -0.02 1.01278E7 -880000.0 -0.5 1.051676E7 -1480994.0331492 -0.869602463854657 -0.7969 -0.7961 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J22 mock treatment 1.093192E7 -346000.0 -0.19 1.13622E7 354000.0 0.2 1.17582E7 -239554.0331492 -0.140660105841141 -0.0783 -0.251 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J23 compound treatment 1.031432E7 -963000.0 -0.54 1.0862E7 -146000.0 -0.08 1.07898E7 -1207954.0331492 -0.70928024012092 -0.7694 -0.8588 654 HSCI1_000128 CC(C)C(CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 J24 mock treatment 9924320.0 -1350000.0 -0.76 1.043064E7 -578000.0 -0.33 1.029116E7 -1706594.0331492 -1.00206911223706 -1.2051 -0.9277 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K01 mock treatment 9612600.0 -1660000.0 -0.94 1.054824E7 -460000.0 -0.26 1.037908E7 -1618674.0331492 -0.950444698558952 -1.2382 -0.9116 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K02 compound treatment 1.112016E7 -157000.0 -0.09 1.010396E7 -904000.0 -0.51 1.240608E7 408325.9668508 0.239758742359173 -0.2065 -0.3625 3055432 HSCI1_000129 CCOC(=O)c1cc(OC)c(OC)cc1NC(=O)c2cc(OC)c(OC)c(OC)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K03 compound treatment 1.0728E7 -550000.0 -0.31 1.008572E7 -923000.0 -0.52 1.154984E7 -447914.0331492 -0.26300385963971 -0.6299 -0.956 570 HSCI1_000130 NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K04 compound treatment 9271240.0 -2010000.0 -1.13 8198320.0 -2810000.0 -1.58 9523160.0 -2474594.0331492 -1.45301940460268 -2.4027 -0.9906 1005921 HSCI1_000131 OCC1OC(Oc2cc(O)c3c(=O)c(coc3c2)c4ccc(O)cc4)C(O)C(O)C1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K05 compound treatment 9308400.0 -1970000.0 -1.11 9220240.0 -1790000.0 -1.01 9936720.0 -2061034.0331492 -1.21018736956267 -1.9184 -0.9972 559 HSCI1_000132 OC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K06 compound treatment 1.164368E7 366000.0 0.21 1.0262E7 -746000.0 -0.42 1.192116E7 -76594.0331491996 -0.0449740906798097 -0.1498 -0.3187 620 HSCI1_000133 COc1cc(/C=C(\C#N)/C(=O)c2ccc(O)c(O)c2)cc(I)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K07 mock treatment 1.07718E7 -506000.0 -0.28 1.085476E7 -153000.0 -0.09 1.247888E7 481125.9668508 0.282505072156331 -0.0508 -0.1239 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K08 mock treatment 1.136E7 82500.0 0.05 1.0774E7 -234000.0 -0.13 1.280776E7 810005.9668508 0.475615140064152 0.2252 0.4543 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K09 mock treatment 1.144084E7 163000.0 0.09 1.055212E7 -456000.0 -0.26 1.295968E7 961925.9668508 0.564818744772727 0.2308 0.368 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K10 mock treatment 1.246692E7 1190000.0 0.67 1.11762E7 168000.0 0.09 1.225656E7 258805.9668508 0.15196435731424 0.528 0.7635 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K11 compound treatment 1.06972E7 -580000.0 -0.33 1.034804E7 -660000.0 -0.37 1.18736E7 -124154.0331492 -0.0729001270143267 -0.4448 -0.8903 553 HSCI1_000134 Oc1cc(C=C(C#N)C#N)ccc1[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K12 compound treatment 1.13112E7 33700.0 0.02 1.005336E7 -955000.0 -0.54 1.082584E7 -1171914.0331492 -0.688118458171887 -0.6967 -0.7977 3176129 HSCI1_000135 Oc1cc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc(I)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K13 compound treatment 1.180484E7 527000.0 0.3 1.092856E7 -79700.0 -0.04 1.234988E7 352125.9668508 0.206759515235542 0.2645 0.7266 1000035 HSCI1_000136 O=C1c2ccccc2-c3n[nH]c4cccc1c34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K14 compound treatment 1.0585E7 -693000.0 -0.39 9923760.0 -1080000.0 -0.61 1.103892E7 -958834.0331492 -0.56300323903482 -0.9021 -0.9837 1 HSCI1_000137 Oc1ccc(/C=C(\C#N)/C(=O)NCCCNC(=O)\C(=C\c2ccc(O)c(O)c2)\C#N)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K15 mock treatment 1.15814E7 304000.0 0.17 1.108076E7 72500.0 0.04 1.24034E7 405645.9668508 0.238185113734772 0.2596 0.8775 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K16 mock treatment 1.16826E7 405000.0 0.23 1.074996E7 -258000.0 -0.15 1.243396E7 436205.9668508 0.256129177451821 0.1953 0.5247 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K17 compound treatment 1.12326E7 -44900.0 -0.03 9713400.0 -1290000.0 -0.73 1.040284E7 -1594914.0331492 -0.936493423888891 -0.9761 -0.8223 554 HSCI1_000138 Oc1cc(C=C(C#N)C#N)cc([N+](=O)[O-])c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K18 compound treatment 1.2261E7 983000.0 0.55 1.04106E7 -598000.0 -0.34 1.25604E7 562645.9668508 0.33037156673139 0.3154 0.4343 3176130 HSCI1_000139 CN(C)c1ccc2c(c3ccccc3C(=O)O)c4ccc(=[N+](C)C)cc4oc2c1.CC(=O)NCCSS(=O)(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K19 compound treatment 1.11304E7 -147000.0 -0.08 1.009036E7 -918000.0 -0.52 1.096636E7 -1031394.0331492 -0.605608646865614 -0.6957 -0.8692 555 HSCI1_000140 Cc1cc2ncc(nc2cc1C)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K20 compound treatment 5302280.0 -5980000.0 -3.36 3388040.0 -7620000.0 -4.29 4051520.0 -7946234.0331492 -4.66582885475821 -7.1081 -0.9911 2311 HSCI1_000141 COC(=O)c1c(c2cc(OC)c(OC)c(OC)c2)c3ccnc(OCc4ncccn4)c3c(=O)n1Cc5ccnc(C)c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K21 mock treatment 1.01394E7 -1140000.0 -0.64 1.016796E7 -840000.0 -0.47 1.190492E7 -92834.0331491996 -0.0545098104037911 -0.6736 -0.8451 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K22 mock treatment 1.08018E7 -476000.0 -0.27 1.0123E7 -885000.0 -0.5 1.187908E7 -118674.0331492 -0.0696824087823428 -0.4822 -0.8464 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K23 mock treatment 1.083056E7 -447000.0 -0.25 1.016528E7 -843000.0 -0.47 1.177972E7 -218034.0331492 -0.128024102857145 -0.4928 -0.893 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 K24 mock treatment 1.071408E7 -563000.0 -0.32 9775720.0 -1230000.0 -0.69 1.131684E7 -680914.0331492 -0.39981560198501 -0.8141 -0.9455 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L01 mock treatment 1.10304E7 -247000.0 -0.14 1.060584E7 -402000.0 -0.23 1.191036E7 -87394.0331491996 -0.0513155791662013 -0.2405 -0.889 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L02 compound treatment 9088880.0 -2190000.0 -1.23 9906240.0 -1100000.0 -0.62 9753400.0 -2244354.0331492 -1.31782826487057 -1.8287 -0.9595 1995 HSCI1_000142 CN(C1CCCCC1)C(=O)CCCOc2ccc3[nH]c(=O)ccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L03 compound treatment 4873520.0 -6400000.0 -3.6 4354640.0 -6650000.0 -3.75 4324600.0 -7673154.0331492 -4.50548314403008 -6.8404 -0.995 3176131 HSCI1_000143 Nc1ncnc2n(cc(I)c12)C3OC(CO)[C@H](O)[C@@H]3O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L04 compound treatment 8595400.0 -2680000.0 -1.51 8492840.0 -2520000.0 -1.42 9287480.0 -2710274.0331492 -1.59140477557238 -2.6061 -0.9989 3055484 HSCI1_000144 COc1cc(SC)ccc1c2nc3ccncc3[nH]2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L05 compound treatment 1.14428E7 165000.0 0.09 1.109588E7 87600.0 0.05 1.22882E7 290445.9668508 0.170542569879928 0.1805 0.9012 1907775 HSCI1_000145 CS(=O)(=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L06 compound treatment 1.20298E7 752000.0 0.42 1.219988E7 1190000.0 0.67 1.31756E7 1177845.9668508 0.69160154051177 1.0305 0.9795 3176132 HSCI1_000146 COc1ccc(cc1)C(=C2C(=O)Nc3ccccc23)c4ccc(OC)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L07 mock treatment 1.179992E7 522000.0 0.29 1.071716E7 -291000.0 -0.16 1.259572E7 597965.9668508 0.35111058278133 0.2775 0.571 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L08 mock treatment 1.081016E7 -467000.0 -0.26 1.110664E7 98400.0 0.06 1.290148E7 903725.9668508 0.530645167929394 0.1868 0.3141 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L09 mock treatment 1.197004E7 693000.0 0.39 1.090716E7 -101000.0 -0.06 1.243836E7 440605.9668508 0.258712746835165 0.3411 0.7248 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L10 mock treatment 1.290116E7 1620000.0 0.91 1.15432E7 535000.0 0.3 1.336452E7 1366765.9668508 0.802530615034835 1.1637 0.9298 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L11 compound treatment 466440.0 -1.08E7 -6.07 302880.0 -1.07E7 -6.03 352440.0 -1.16453140331492E7 -6.83783563533612 -10.9329 -0.9983 3055486 HSCI1_000147 O=C1NC(=O)c2c1c3c4ccccc4n5C6CCC(O6)n7c8ccccc8c2c7c53 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L12 compound treatment 1.059616E7 -681000.0 -0.38 9758760.0 -1250000.0 -0.7 9969400.0 -2028354.0331492 -1.19099849514274 -1.3147 -0.916 3176133 HSCI1_000148 OC(=O)c1ccc(Cl)cc1NC(=O)Nc2cccc(c2)C(F)(F)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L13 compound treatment 4943600.0 -6330000.0 -3.56 3839440.0 -7170000.0 -4.04 3378280.0 -8619474.0331492 -5.06113845740434 -7.3059 -0.9891 3176134 HSCI1_000149 O/N=C\1/C(=C\2/C(=O)Nc3ccc(I)cc23)/Nc4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L14 compound treatment 3331920.0 -7950000.0 -4.46 1516880.0 -9490000.0 -5.34 800480.0 -1.11972740331492E7 -6.57475781112844 -9.4573 -0.9877 3055490 HSCI1_000150 COc1cc(ccc1c2nc3ccncc3[nH]2)S(=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L15 mock treatment 1.22416E7 964000.0 0.54 1.123008E7 222000.0 0.12 1.270788E7 710125.9668508 0.416968115062226 0.6255 0.9003 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L16 mock treatment 1.177612E7 499000.0 0.28 1.147556E7 467000.0 0.26 1.243992E7 442165.9668508 0.259628739616533 0.4635 0.9994 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L17 compound treatment 1.164984E7 372000.0 0.21 1.033008E7 -678000.0 -0.38 1.183332E7 -164434.0331492 -0.0965515303691279 -0.1554 -0.3486 3176135 HSCI1_000151 C[S+](O)c1ccc(CSc2nc(c([nH]2)c3ccc(F)cc3)c4ccncc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L18 compound treatment 1.25388E7 1260000.0 0.71 1.121248E7 204000.0 0.11 1.292596E7 928205.9668508 0.545019208498548 0.7901 0.8767 2109556 HSCI1_000152 Nc1n[nH]c2nc3ccccc3nc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L19 compound treatment 1.205572E7 778000.0 0.44 1.116596E7 158000.0 0.09 1.240328E7 405525.9668508 0.23811465275159 0.4411 0.8724 3176136 HSCI1_000153 C[C@@H]1C2NCC(C)C[C@H]2O[C@@]31CCC4C5CC=C6CC(O)CCC6(C)C5C(=O)C4=C3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L20 compound treatment 1.152012E7 243000.0 0.14 1.102784E7 19600.0 0.01 1.194736E7 -50394.0331491996 -0.0295901093517116 0.068 0.4858 3055494 HSCI1_000154 OB(O)c1ccc(cc1)C(=O)/C=C/c2ccc(I)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L21 mock treatment 1.046276E7 -815000.0 -0.46 1.095984E7 -48400.0 -0.03 1.174156E7 -256194.0331492 -0.150430695509062 -0.3668 -0.7602 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L22 mock treatment 1.110304E7 -174000.0 -0.1 1.068728E7 -321000.0 -0.18 1.171296E7 -284794.0331492 -0.167223896500803 -0.2574 -0.9716 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L23 mock treatment 1.104008E7 -237000.0 -0.13 1.078764E7 -221000.0 -0.12 1.122776E7 -769994.0331492 -0.452121138500544 -0.4097 -0.8405 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 L24 mock treatment 1.104676E7 -231000.0 -0.13 9695400.0 -1310000.0 -0.74 1.155124E7 -446514.0331492 -0.262181814835919 -0.6529 -0.8215 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M01 mock treatment 1.079664E7 -481000.0 -0.27 1.06304E7 -378000.0 -0.21 1.08404E7 -1157354.0331492 -0.679569192212455 -0.6711 -0.8812 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M02 compound treatment 502480.0 -1.08E7 -6.05 476280.0 -1.05E7 -5.93 553280.0 -1.14444740331492E7 -6.71990743648363 -10.7968 -0.9984 2095175 HSCI1_000155 Oc1ccc(/C=C(\C#N)/C(=O)NC2CCC(CC3CCC(CC3)NC(=O)\C(=C\c4ccc(O)c(O)c4)\C#N)CC2)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M03 compound treatment 1.02908E7 -987000.0 -0.55 9849000.0 -1160000.0 -0.65 1.084168E7 -1156074.0331492 -0.678817608391846 -1.0887 -0.9964 552 HSCI1_000156 NC(=C(C#N)C#N)/C(=C/c1ccc(O)cc1)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M04 compound treatment 1.028472E7 -993000.0 -0.56 1.011952E7 -889000.0 -0.5 1.1112E7 -885754.0331492 -0.520092500276904 -0.9111 -0.999 613 HSCI1_000157 Oc1cc(/C=C/c2ccc(O)c(O)c2)oc(=O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M05 compound treatment 1.020172E7 -1080000.0 -0.6 1.051352E7 -495000.0 -0.28 1.186256E7 -135194.0331492 -0.0793825374670826 -0.5555 -0.829 657 HSCI1_000158 COc1ccc(/C=C(\C#N)/c2cccnc2)cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M06 compound treatment 8942680.0 -2330000.0 -1.31 8125000.0 -2880000.0 -1.62 9427640.0 -2570114.0331492 -1.50910634721566 -2.5655 -0.9962 3176139 HSCI1_000159 CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)CCCCCCCCC)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M07 compound treatment 6802560.0 -4470000.0 -2.51 6255640.0 -4750000.0 -2.68 7968040.0 -4029714.0331492 -2.36614677265428 -4.3618 -0.9987 671 HSCI1_000160 NC(=C(C#N)C#N)/C(=C/c1cc(O)c(O)c(O)c1)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M08 compound treatment 1.07238E7 -554000.0 -0.31 1.007428E7 -934000.0 -0.53 1.131128E7 -686474.0331492 -0.403080294205782 -0.7158 -0.9781 3176140 HSCI1_000161 Nc1ncnc2n(cnc12)C3OC(CO)[C@H](O)[C@@H]3S 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M09 mock treatment 1.19548E7 677000.0 0.38 1.194132E7 933000.0 0.53 1.22734E7 275645.9668508 0.161852381954132 0.6163 0.9221 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M10 mock treatment 1.140476E7 127000.0 0.07 1.180528E7 797000.0 0.45 1.277252E7 774765.9668508 0.454923098003 0.5629 0.8756 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M11 mock treatment 1.141248E7 135000.0 0.08 1.17656E7 757000.0 0.43 1.289308E7 895325.9668508 0.525712899106645 0.5934 0.8713 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M12 mock treatment 1.214304E7 866000.0 0.49 1.15706E7 562000.0 0.32 1.272744E7 729685.9668508 0.428453255320914 0.7108 0.9856 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M13 mock treatment 1.344936E7 2170000.0 1.22 1.19944E7 986000.0 0.56 1.39976E7 1999845.9668508 1.17425927530935 1.7028 0.9556 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M14 mock treatment 1.21012E7 824000.0 0.46 1.152956E7 521000.0 0.29 1.333976E7 1342005.9668508 0.787992165504922 0.8915 0.9289 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M15 compound treatment 1.19378E7 660000.0 0.37 1.118172E7 173000.0 0.1 1.26372E7 639445.9668508 0.375466595967953 0.4873 0.9079 585 HSCI1_000162 Oc1ccc(C(=O)/C=C/c2ccc(O)c(O)c2)c(O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M16 compound treatment 1.301004E7 1730000.0 0.97 1.187028E7 862000.0 0.49 1.311776E7 1120005.9668508 0.657639346617984 1.2217 0.9613 2024 HSCI1_000163 CN(N=O)c1cc(O)ccc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M17 compound treatment 1.130924E7 31700.0 0.02 1.170728E7 699000.0 0.39 1.23406E7 342845.9668508 0.201310532536124 0.3537 0.7996 569 HSCI1_000164 COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M18 compound treatment 1.10514E7 -226000.0 -0.13 1.090656E7 -102000.0 -0.06 1.177916E7 -218594.0331492 -0.128352920778662 -0.1805 -0.9528 1890 HSCI1_000165 CN(N=O)c1ccc(O)c(O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M19 compound treatment 6922640.0 -4350000.0 -2.45 5470880.0 -5540000.0 -3.12 4729760.0 -7267994.0331492 -4.26758337781282 -5.6757 -0.9747 1008455 HSCI1_000166 BrCC(=O)c1ccc(Br)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M20 compound treatment 5957160.0 -5320000.0 -2.99 5119280.0 -5890000.0 -3.31 5842160.0 -6155594.0331492 -3.61441006371448 -5.726 -0.997 3176141 HSCI1_000167 CCN(N=O)c1ccc(O)c(O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M21 compound treatment 1.084472E7 -433000.0 -0.24 1.06232E7 -385000.0 -0.22 1.172044E7 -277314.0331492 -0.162831828549117 -0.3595 -0.9873 560 HSCI1_000168 Oc1ccc(/C=C(\C#N)/C(=O)Nc2ccccc2)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M22 compound treatment 1.036484E7 -913000.0 -0.51 9825600.0 -1180000.0 -0.67 1.08682E7 -1129554.0331492 -0.663245731108596 -1.0633 -0.9933 566 HSCI1_000169 COc1cc(/C=C(\C#N)/C(=O)N)cc(CSc2nc3ccccc3s2)c1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M23 mock treatment 1.0993E7 -285000.0 -0.16 1.018904E7 -819000.0 -0.46 1.125528E7 -742474.0331492 -0.435962086357442 -0.6102 -0.9325 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 M24 mock treatment 9957040.0 -1320000.0 -0.74 1.04946E7 -514000.0 -0.29 1.04724E7 -1525354.0331492 -0.89564954063765 -1.1123 -0.9282 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N01 mock treatment 1.115228E7 -125000.0 -0.07 1.418412E7 3180000.0 1.79 1.414532E7 2147565.9668508 1.26099674560655 1.7196 0.7856 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N02 compound treatment 1.18474E7 570000.0 0.32 1.158428E7 576000.0 0.32 1.227512E7 277365.9668508 0.162862322713076 0.466 0.9632 837968 HSCI1_000170 Nc1ncnc2n(cnc12)C3CCCO3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N03 compound treatment 5138120.0 -6140000.0 -3.45 4190000.0 -6820000.0 -3.84 4701800.0 -7295954.0331492 -4.28400078689425 -6.6802 -0.9961 3176143 HSCI1_000171 CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](OC(=O)CCC(=O)O)[C@@]3(C)O[C@](C)(CC(=O)[C@@]32O)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N04 compound treatment 192720.0 -1.11E7 -6.23 185520.0 -1.08E7 -6.09 238720.0 -1.17590340331492E7 -6.90460916039838 -11.0984 -0.9985 831810 HSCI1_000172 Brc1c(Br)c(Br)c2[nH]nnc2c1Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N05 compound treatment 1.054084E7 -737000.0 -0.41 1.090552E7 -103000.0 -0.06 1.68986E7 4900845.9668508 2.87765354373732 1.3891 0.4777 3054768 HSCI1_000173 C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@@]42OC(=O)/C=C\[C@H](O)CCC[C@@H](C)C/C=C\[C@H]4C(=O)C1=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N06 compound treatment 1.026628E7 -1010000.0 -0.57 9184840.0 -1820000.0 -1.03 1.029072E7 -1707034.0331492 -1.00232746917539 -1.4992 -0.9716 3054769 HSCI1_000174 Cn1sc(=O)n(Cc2ccccc2)c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N07 compound treatment 700560.0 -1.06E7 -5.94 183200.0 -1.08E7 -6.09 268640.0 -1.17291140331492E7 -6.88704088859163 -10.9243 -0.9978 621 HSCI1_000175 CS(=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4cccc(I)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N08 compound treatment 1.202416E7 747000.0 0.42 1.154904E7 541000.0 0.3 1.233228E7 334525.9668508 0.196425237702163 0.5313 0.9587 3054770 HSCI1_000176 c1ccc(cc1)c2n[nH]c3c2oc4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N09 mock treatment 1.213668E7 859000.0 0.48 1.218772E7 1180000.0 0.66 1.329924E7 1301485.9668508 0.764199840183757 1.1031 0.9837 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N10 mock treatment 1.27764E7 1500000.0 0.84 1.210068E7 1090000.0 0.61 1.303236E7 1034605.9668508 0.607494613586703 1.1918 0.9877 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N11 mock treatment 1.26942E7 1420000.0 0.8 1.209972E7 1090000.0 0.61 1.30936E7 1095845.9668508 0.643453202003982 1.1856 0.9933 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N12 mock treatment 1.376812E7 2490000.0 1.4 1.231284E7 1300000.0 0.73 1.44756E7 2477845.9668508 1.45492885831817 2.0717 0.9645 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N13 mock treatment 1.320708E7 1930000.0 1.08 1.231728E7 1310000.0 0.74 1.34262E7 1428445.9668508 0.838747560390449 1.5354 0.9868 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N14 mock treatment 1.269768E7 1420000.0 0.8 1.191648E7 908000.0 0.51 1.360648E7 1608725.9668508 0.944603444124401 1.3011 0.9725 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N15 compound treatment 7334480.0 -3940000.0 -2.21 6358880.0 -4650000.0 -2.62 7157960.0 -4839794.0331492 -2.84180538312244 -4.4304 -0.9949 3176144 HSCI1_000177 CC1C2C(Cc3ccccc3)NC(=O)C42OC(=O)O/C=C\C(C)(O)C(=O)C(C)C/C=C\C4C5OC51C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N16 compound treatment 1.112464E7 -153000.0 -0.09 1.074732E7 -261000.0 -0.15 1.177824E7 -219514.0331492 -0.128893121649725 -0.2088 -0.9782 1056418 HSCI1_000178 Nc1ncnc2n(cnc12)C3CCC(CO)O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N17 compound treatment 1.1057E7 -221000.0 -0.12 1.196268E7 954000.0 0.54 1.280052E7 802765.9668508 0.47136399407883 0.5108 0.7042 2177 HSCI1_000179 CC(C)CC[C@@H](O)[C@](C)(O)C1CC[C@@]2(O)C3=CC(=O)[C@]4(O)C[C@@H](O)[C@@H](O)C[C@]4(C)C3[C@H](O)C[C@]12C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N18 compound treatment 1.136716E7 89600.0 0.05 1.129772E7 289000.0 0.16 1.250916E7 511405.9668508 0.300284726912621 0.2965 0.8586 3054771 HSCI1_000180 COc1ccc2NC(=O)/C(=C\c3c[nH]cn3)/c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N19 compound treatment 7721480.0 -3560000.0 -2.0 7360400.0 -3650000.0 -2.05 7713360.0 -4284394.0331492 -2.51568846596115 -3.7912 -0.9944 3176146 HSCI1_000181 CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)CCC)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N20 compound treatment 1.044872E7 -829000.0 -0.47 1.076048E7 -248000.0 -0.14 1.0975E7 -1022754.0331492 -0.600535456076501 -0.696 -0.9009 2127 HSCI1_000182 CC1(C)CCC2=C(O1)c3ccccc3C(=O)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N21 compound treatment 7912880.0 -3360000.0 -1.89 7371840.0 -3640000.0 -2.05 8288400.0 -3709354.0331492 -2.17803943455239 -3.5304 -0.9983 3054772 HSCI1_000183 CC(C)(O)/C=C/C(=O)[C@](C)(O)C1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4C(C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@@]12C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N22 compound treatment 1.102904E7 -248000.0 -0.14 1.071984E7 -288000.0 -0.16 1.14682E7 -529554.0331492 -0.310940815197952 -0.3538 -0.9373 1937872 HSCI1_000184 [O-][N+](=O)c1ccccc1c2ccc(C=C3C(=O)N(C(=S)N(C3=O)c4ccccc4)c5ccccc5)o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N23 mock treatment 1.178752E7 510000.0 0.29 1.10836E7 75400.0 0.04 1.185916E7 -138594.0331492 -0.0813789319905762 0.1429 0.475 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 N24 mock treatment 1.065532E7 -622000.0 -0.35 1.012536E7 -883000.0 -0.5 1.112116E7 -876594.0331492 -0.514713978560668 -0.7859 -0.9869 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O01 mock treatment 1.05414E7 -736000.0 -0.41 1.043884E7 -569000.0 -0.32 9967520.0 -2030234.0331492 -1.19210238387926 -1.112 -0.8542 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O02 mock treatment 1.164716E7 370000.0 0.21 1.051304E7 -495000.0 -0.28 1.179432E7 -203434.0331492 -0.11945134990332 -0.11 -0.2994 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O03 compound treatment 1.085816E7 -419000.0 -0.24 1.028964E7 -719000.0 -0.4 8622480.0 -3375274.0331492 -1.98187605737335 -1.5138 -0.7434 5 HSCI1_000185 CC(C)(C)c1cc(C=C(C#N)C#N)cc(c1O)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O04 compound treatment 3091320.0 -8190000.0 -4.6 3577160.0 -7430000.0 -4.18 3924000.0 -8073754.0331492 -4.74070539288642 -7.8068 -0.9986 2090 HSCI1_000186 CCOC(=O)C(C#N)C1C(=C(N)Oc2ccc(Br)cc12)C(=O)OCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O05 compound treatment 1435800.0 -9840000.0 -5.53 993680.0 -1.0E7 -5.64 1044720.0 -1.09530340331492E7 -6.43134622335841 -10.1594 -0.9977 2107241 HSCI1_000187 ClC1=C(N2C(=O)CCC2=O)C(=O)c3ccccc3C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O06 compound treatment 9784880.0 -1490000.0 -0.84 9364680.0 -1640000.0 -0.93 9203480.0 -2794274.0331492 -1.64072746379987 -1.9655 -0.9533 651 HSCI1_000188 Nc1ncnc2n(ncc12)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O07 compound treatment 418360.0 -1.09E7 -6.1 571640.0 -1.04E7 -5.87 715440.0 -1.12823140331492E7 -6.62469116121018 -10.7381 -0.9987 562 HSCI1_000189 Oc1ccc(/C=C(\C#N)/C(=O)c2ccc(O)c(O)c2)cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O08 compound treatment 7976720.0 -3300000.0 -1.85 243160.0 -1.08E7 -6.06 6898840.0 -5098914.0331492 -2.99395413280705 -6.2976 -0.8985 3176147 HSCI1_000190 CS/C(=C(\C#N)/C(=C(\N)/SC)/[N+]#[C-])/N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O09 compound treatment 9269640.0 -2010000.0 -1.13 9441800.0 -1570000.0 -0.88 9011280.0 -2986474.0331492 -1.75358247186325 -2.1727 -0.9598 3176148 HSCI1_000191 OCc1cc2ncnc(Nc3ccc(O)cc3)c2cc1CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O10 compound treatment 1.216572E7 888000.0 0.5 1.137392E7 366000.0 0.21 1.247404E7 476285.9668508 0.279663145834652 0.5683 0.935 3054774 HSCI1_000192 Nc1ccc(cc1)c2cc(=O)c3cc(O)ccc3o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O11 mock treatment 1.169224E7 415000.0 0.23 1.172692E7 719000.0 0.4 1.227972E7 281965.9668508 0.165563327068391 0.4636 0.9361 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O12 mock treatment 1.245836E7 1180000.0 0.66 1.199708E7 989000.0 0.56 1.31706E7 1172845.9668508 0.688665666212515 1.1019 0.996 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O13 mock treatment 1.190444E7 627000.0 0.35 1.240136E7 1390000.0 0.78 1.227948E7 281725.9668508 0.165422405102027 0.7516 0.8585 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O14 mock treatment 1.296916E7 1690000.0 0.95 1.159524E7 587000.0 0.33 1.307636E7 1078605.9668508 0.63333030742015 1.105 0.9296 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O15 compound treatment 1.124196E7 -35600.0 -0.02 1.10726E7 64400.0 0.04 1.192512E7 -72634.0331491996 -0.0426488782347994 -0.0152 -0.2566 3176208 HSCI1_000193 COc1ccc(N=O)c(CCc2cc(OC)ccc2N=O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O16 compound treatment 4641960.0 -6640000.0 -3.73 4627400.0 -6380000.0 -3.59 5762600.0 -6235154.0331492 -3.66112569556423 -6.3393 -0.9999 3054775 HSCI1_000194 CC(C)(C)OC(=O)NC(CC(=O)O)C(=O)OCCF 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O17 compound treatment 9300680.0 -1980000.0 -1.11 8905080.0 -2100000.0 -1.18 9643400.0 -2354354.0331492 -1.38241749945419 -2.1227 -0.9956 1860 HSCI1_000195 CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O18 compound treatment 1660720.0 -9620000.0 -5.4 569680.0 -1.04E7 -5.88 738280.0 -1.12594740331492E7 -6.61128008741118 -10.3281 -0.9965 634 HSCI1_000196 OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O19 compound treatment 1.06512E7 -626000.0 -0.35 1.105188E7 43600.0 0.02 1.114204E7 -855714.0331492 -0.502453767486978 -0.479 -0.7803 589 HSCI1_000197 Nc1cc(Nc2ccc(cc2)S(=O)(=O)N)ncn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O20 compound treatment 671720.0 -1.06E7 -5.96 310520.0 -1.07E7 -6.02 366120.0 -1.16316340331492E7 -6.82980308325335 -10.8592 -0.998 3054776 HSCI1_000198 Oc1ccc2[nH]c(cc2c1)C(=O)c3cc4ccccc4[nH]3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O21 compound treatment 1.115676E7 -121000.0 -0.07 1.0619E7 -389000.0 -0.22 1.161528E7 -382474.0331492 -0.224579136811056 -0.2953 -0.92 557 HSCI1_000199 Cc1cc2ncc(nc2cc1C)c3ccc(O)c(O)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O22 compound treatment 1.045292E7 -825000.0 -0.46 1.048456E7 -524000.0 -0.29 1.0534E7 -1463754.0331492 -0.859479569270824 -0.9338 -0.9156 1000586 HSCI1_000200 O/N=C\1/C(=C\2/C(=O)Nc3ccccc23)/Nc4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O23 mock treatment 1.02536E7 -1020000.0 -0.58 1.045552E7 -553000.0 -0.31 1.051292E7 -1484834.0331492 -0.871857215316485 -1.015 -0.9314 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 O24 mock treatment 9695600.0 -1580000.0 -0.89 9339440.0 -1670000.0 -0.94 1.015668E7 -1841074.0331492 -1.08103238738983 -1.6795 -0.9965 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P01 mock treatment 9451080.0 -1830000.0 -1.03 9710400.0 -1300000.0 -0.73 1.004768E7 -1950074.0331492 -1.1450344471136 -1.6752 -0.9842 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P02 mock treatment 1.155292E7 275000.0 0.15 1.070072E7 -308000.0 -0.17 1.143296E7 -564794.0331492 -0.331632857259104 -0.2021 -0.4993 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P03 mock treatment 1.043576E7 -842000.0 -0.47 1.07138E7 -294000.0 -0.17 1.013092E7 -1866834.0331492 -1.09615801177959 -1.0015 -0.831 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P04 mock treatment 1.053568E7 -742000.0 -0.42 1.048916E7 -519000.0 -0.29 1.177292E7 -224834.0331492 -0.132016891904133 -0.4855 -0.9234 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P05 mock treatment 1.260484E7 1330000.0 0.75 1.133188E7 324000.0 0.18 1.262596E7 628205.9668508 0.368866750543227 0.7486 0.8791 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P06 mock treatment 1.005048E7 -1230000.0 -0.69 1.158348E7 575000.0 0.32 1.208084E7 83085.9668508004 0.0487859909412096 -0.1828 -0.2396 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P07 mock treatment 1.163508E7 358000.0 0.2 1.107808E7 69800.0 0.04 1.204848E7 50725.9668508004 0.0297850124764289 0.1558 0.7536 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P08 mock treatment 1.243152E7 1150000.0 0.65 1.046636E7 -542000.0 -0.31 1.25044E7 506645.9668508 0.29748977457973 0.3699 0.4768 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P09 mock treatment 1.16604E7 383000.0 0.22 1.072376E7 -284000.0 -0.16 1.257288E7 575125.9668508 0.337699508982332 0.2267 0.5257 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P10 mock treatment 1.087116E7 -406000.0 -0.23 1.122324E7 215000.0 0.12 1.2138E7 140245.9668508 0.082348905930297 -0.0144 -0.053 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P11 mock treatment 1.202552E7 748000.0 0.42 1.145016E7 442000.0 0.25 1.320288E7 1205125.9668508 0.707619670688508 0.7947 0.9244 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P12 mock treatment 1.171772E7 440000.0 0.25 1.145492E7 447000.0 0.25 1.228556E7 287805.9668508 0.168992428249921 0.3855 0.9858 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P13 mock treatment 1.243296E7 1160000.0 0.65 1.207432E7 1070000.0 0.6 1.268416E7 686405.9668508 0.403040327386559 0.9539 0.9819 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P14 mock treatment 1.17826E7 505000.0 0.28 1.100632E7 -1930.0 0.0 1.2424E7 426245.9668508 0.250280915847704 0.3077 0.8132 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P15 mock treatment 1.14302E7 153000.0 0.09 1.142956E7 421000.0 0.24 1.225172E7 253965.9668508 0.149122430992561 0.2725 0.9302 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P16 mock treatment 1.066884E7 -609000.0 -0.34 1.114988E7 142000.0 0.08 1.202924E7 31485.9668508004 0.0184877681728943 -0.1407 -0.4002 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P17 mock treatment 1.077864E7 -499000.0 -0.28 1.129056E7 282000.0 0.16 1.206464E7 66885.9668508004 0.0392737582116223 -0.0474 -0.1459 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P18 mock treatment 1.119508E7 -82400.0 -0.05 1.138344E7 375000.0 0.21 1.196056E7 -37194.0331491996 -0.0218394012016774 0.0826 0.38 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P19 mock treatment 1.177608E7 499000.0 0.28 1.061908E7 -389000.0 -0.22 1.263136E7 633605.9668508 0.372037494786422 0.25 0.4858 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P20 mock treatment 1.051692E7 -761000.0 -0.43 1.045044E7 -558000.0 -0.31 1.085484E7 -1142914.0331492 -0.671090387236206 -0.8154 -0.9534 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P21 mock treatment 1.103192E7 -246000.0 -0.14 1.0094E7 -914000.0 -0.51 1.190348E7 -94274.0331491996 -0.0553553422019767 -0.4087 -0.763 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P22 mock treatment 1.02686E7 -1010000.0 -0.57 9772240.0 -1240000.0 -0.7 1.088512E7 -1112634.0331492 -0.653310732479915 -1.1061 -0.9965 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P23 mock treatment 9449080.0 -1830000.0 -1.03 9508920.0 -1500000.0 -0.84 1.045128E7 -1546474.0331492 -0.908050673677705 -1.6045 -0.9967 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2104 P24 mock treatment 8828080.0 -2450000.0 -1.38 8153400.0 -2850000.0 -1.61 8509760.0 -3487994.0331492 -2.04806240757576 -2.9046 -0.9865 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A01 mock treatment 9119320.0 -3060000.0 -1.72 9082800.0 -2920000.0 -1.64 9325840.0 -1905383.3333333 -1.11879319171255 -2.5865 -0.9844 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A02 mock treatment 1.025876E7 -1920000.0 -1.08 1.00406E7 -1960000.0 -1.11 1.026292E7 -968303.3333333 -0.568563374043307 -1.5881 -0.9657 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A03 mock treatment 1.089744E7 -1280000.0 -0.72 1.108832E7 -915000.0 -0.52 1.059264E7 -638583.3333333 -0.374960079253212 -0.9287 -0.9672 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A04 mock treatment 1.136428E7 -812000.0 -0.46 1.111396E7 -890000.0 -0.5 1.123308E7 1856.66666669957 0.00109018798980948 -0.5518 -0.8147 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A05 mock treatment 1.112812E7 -1050000.0 -0.59 1.06514E7 -1350000.0 -0.76 1.067036E7 -560863.3333333 -0.329324849145586 -0.9695 -0.9532 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A06 mock treatment 1.15176E7 -658000.0 -0.37 1.171752E7 -286000.0 -0.16 1.05152E7 -716023.3333333 -0.420430900400079 -0.5493 -0.9427 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A07 mock treatment 1.156884E7 -607000.0 -0.34 1.188448E7 -119000.0 -0.07 1.126216E7 30936.6666666996 0.0181652329142787 -0.2252 -0.647 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A08 mock treatment 1.11912E7 -985000.0 -0.55 1.16626E7 -341000.0 -0.19 1.154096E7 309736.6666667 0.181869583840758 -0.3253 -0.5305 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A09 mock treatment 1.113976E7 -1040000.0 -0.58 1.121152E7 -792000.0 -0.45 1.027328E7 -957943.3333333 -0.56248024249525 -0.9183 -0.9936 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A10 mock treatment 1.177096E7 -405000.0 -0.23 1.181148E7 -192000.0 -0.11 1.095248E7 -278743.3333333 -0.163671077684402 -0.2884 -0.9597 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A11 mock treatment 1.126516E7 -911000.0 -0.51 1.14038E7 -600000.0 -0.34 1.099136E7 -239863.3333333 -0.140841719133392 -0.5717 -0.9089 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A12 mock treatment 1.130612E7 -870000.0 -0.49 1.173096E7 -273000.0 -0.15 1.123756E7 6336.66666669957 0.00372073136194229 -0.3686 -0.7197 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A13 mock treatment 1.170644E7 -470000.0 -0.26 1.214736E7 144000.0 0.08 1.115928E7 -71943.3333333004 -0.0422433166671997 -0.13 -0.4659 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A14 mock treatment 1.197232E7 -204000.0 -0.11 1.174744E7 -256000.0 -0.14 1.006032E7 -1170903.3333333 -0.687525000649135 -0.5463 -0.7676 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A15 mock treatment 1.178472E7 -391000.0 -0.22 1.169884E7 -305000.0 -0.17 1.136568E7 134456.6666667 0.0789495744060618 -0.1804 -0.6225 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A16 mock treatment 1.191388E7 -262000.0 -0.15 1.16098E7 -394000.0 -0.22 1.097936E7 -251863.3333333 -0.147887817451605 -0.2985 -0.98 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A17 mock treatment 1.142432E7 -752000.0 -0.42 1.146296E7 -541000.0 -0.3 1.092864E7 -302583.3333333 -0.177669326343251 -0.5221 -0.9493 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A18 mock treatment 1.142864E7 -747000.0 -0.42 1.152288E7 -481000.0 -0.27 1.086284E7 -368383.3333333 -0.216305432121452 -0.5236 -0.9618 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A19 mock treatment 1.176936E7 -407000.0 -0.23 1.12384E7 -765000.0 -0.43 1.021408E7 -1017143.3333333 -0.597240994198434 -0.7255 -0.9409 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A20 mock treatment 1.09944E7 -1180000.0 -0.66 1.10702E7 -934000.0 -0.53 1.08188E7 -412423.3333333 -0.242164612949293 -0.8264 -0.9385 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A21 mock treatment 1.08682E7 -1310000.0 -0.73 1.061692E7 -1390000.0 -0.78 1.008916E7 -1142063.3333333 -0.67059087769103 -1.262 -0.9981 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A22 mock treatment 1.046976E7 -1710000.0 -0.96 1.021032E7 -1790000.0 -1.01 8620600.0 -2610623.3333333 -1.53289238987392 -2.0212 -0.9761 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A23 mock treatment 9638680.0 -2540000.0 -1.43 9774200.0 -2230000.0 -1.26 9360400.0 -1870823.3333333 -1.0985004285561 -2.1817 -0.9944 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 A24 mock treatment 8721120.0 -3450000.0 -1.94 8618840.0 -3380000.0 -1.91 9111840.0 -2119383.3333333 -1.24444861172068 -2.939 -0.9827 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B01 mock treatment 1.10754E7 -1100000.0 -0.62 1.1155E7 -849000.0 -0.48 1.022124E7 -1009983.3333333 -0.5930368222019 -0.9752 -0.9942 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B02 mock treatment 1.210536E7 -70700.0 -0.04 1.139944E7 -604000.0 -0.34 1.155408E7 322856.6666667 0.189573318002004 -0.1099 -0.2807 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B03 compound treatment 7932160.0 -4240000.0 -2.38 8154960.0 -3850000.0 -2.17 8244080.0 -2987143.3333333 -1.75397546810505 -3.6398 -0.9924 577 HSCI1_000201 CN1C(=O)C(=C(C1=O)c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B04 compound treatment 6627360.0 -5550000.0 -3.12 7040600.0 -4960000.0 -2.79 6919560.0 -4311663.3333333 -2.53170031347499 -4.8741 -0.9964 614 HSCI1_000202 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B05 compound treatment 1.232084E7 145000.0 0.08 1.174204E7 -262000.0 -0.15 1.098852E7 -242703.3333333 -0.142509295735369 -0.1204 -0.546 907102 HSCI1_000203 NCCCCCCNS(=O)(=O)c1cccc2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B06 compound treatment 1.293552E7 759000.0 0.43 1.221304E7 209000.0 0.12 1.202836E7 797136.6666667 0.468058610532171 0.5845 0.9074 1012954 HSCI1_000204 OC(Cc1ccncc1)C(Cl)(Cl)Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B07 compound treatment 1.0051E7 -2130000.0 -1.19 9451400.0 -2550000.0 -1.44 9691280.0 -1539943.3333333 -0.904216010928575 -2.0407 -0.9834 3176210 HSCI1_000205 CCCC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c3cc4ccccc4[nH]3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B08 compound treatment 8062240.0 -4110000.0 -2.31 7846200.0 -4160000.0 -2.34 6994640.0 -4236583.3333333 -2.48761522499737 -4.1215 -0.9995 321 HSCI1_000206 O=c1cc(oc2c(cccc12)c3ccccc3)N4CCOCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B09 compound treatment 506760.0 -1.17E7 -6.55 565920.0 -1.14E7 -6.44 474320.0 -1.07569033333333E7 -6.31618320718152 -11.1481 -0.9999 3176211 HSCI1_000207 C[C@@H](O)[C@]1(C)CC[C@@H](O1)[C@]2(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)/C(=C/C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(=O)O)/O)O2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B10 compound treatment 1.383084E7 1650000.0 0.93 1.385952E7 1860000.0 1.04 1.30862E7 1854976.6666667 1.08919566427703 1.7686 0.9978 3103895 HSCI1_000208 C[C@@H]1CC2C3CCC4=CC(=O)C=CC4(C)[C@@]3(F)[C@@H](O)CC2(C)[C@@]1(O)C(=O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B11 mock treatment 1.221924E7 43200.0 0.02 1.276472E7 761000.0 0.43 1.205228E7 821056.6666667 0.482103833179808 0.5396 0.8362 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B12 mock treatment 1.289672E7 721000.0 0.4 1.2364E7 360000.0 0.2 1.260724E7 1376016.6666667 0.80796239340276 0.8172 0.8824 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B13 mock treatment 1.316288E7 987000.0 0.55 1.329524E7 1290000.0 0.73 1.20786E7 847376.6666667 0.497558275491089 1.027 0.9867 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B14 mock treatment 1.259632E7 420000.0 0.24 1.270736E7 704000.0 0.4 1.153832E7 307096.6666667 0.180319442210751 0.469 0.9475 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B15 compound treatment 6794880.0 -5380000.0 -3.02 5937000.0 -6070000.0 -3.42 4951760.0 -6279463.3333333 -3.68714300268993 -5.8455 -0.9967 1940 HSCI1_000209 NSC(=S)N1CCCC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B16 compound treatment 1.276332E7 587000.0 0.33 1.23696E7 366000.0 0.21 1.184176E7 610536.6666667 0.358491781683961 0.5163 0.9762 1000071 HSCI1_000210 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B17 compound treatment 1.20708E7 -105000.0 -0.06 1.202096E7 17200.0 0.01 1.195244E7 721216.6666667 0.423480295172277 0.2159 0.5049 3176212 HSCI1_000211 Nc1ncnc2n(cnc12)C3OC(CO)[C@H](O)[C@@H]3O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B18 compound treatment 1.189188E7 -284000.0 -0.16 1.13846E7 -619000.0 -0.35 1.07102E7 -521023.3333333 -0.30593180272912 -0.47 -0.9583 831767 HSCI1_000212 NCCCNCCCCNCCCN 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B19 compound treatment 1.238324E7 207000.0 0.12 1.262876E7 625000.0 0.35 1.105796E7 -173263.3333333 -0.10173587346731 0.2116 0.5506 3054778 HSCI1_000213 NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B20 compound treatment 1.246968E7 294000.0 0.16 1.231468E7 311000.0 0.18 1.203484E7 803616.6666667 0.471863503624006 0.4687 0.885 2293 HSCI1_000214 CSC(=N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B21 compound treatment 1.150392E7 -672000.0 -0.38 1.126436E7 -739000.0 -0.42 9905200.0 -1326023.3333333 -0.778607564909233 -0.9078 -0.9454 1001920 HSCI1_000215 CNC[C@H](O)c1ccc(O)c(O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B22 compound treatment 1.175128E7 -425000.0 -0.24 1.17172E7 -287000.0 -0.16 1.095744E7 -273783.3333333 -0.16075869037954 -0.3237 -0.9814 3054779 HSCI1_000216 CN/C(=N\C)/NCCC[C@H](N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B23 mock treatment 1.122116E7 -955000.0 -0.54 1.146224E7 -542000.0 -0.3 1.057608E7 -655143.3333333 -0.384683694932346 -0.7078 -0.9735 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 B24 mock treatment 9879000.0 -2300000.0 -1.29 9846040.0 -2160000.0 -1.21 9893920.0 -1337303.3333333 -0.785230897328353 -1.8995 -0.9801 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C01 mock treatment 1.147104E7 -705000.0 -0.4 1.11406E7 -863000.0 -0.49 1.18976E7 666376.6666667 0.391279625858045 -0.2833 -0.3833 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C02 mock treatment 1.18402E7 -336000.0 -0.19 1.185424E7 -150000.0 -0.08 1.165928E7 428056.6666667 0.251344113258337 -0.0124 -0.0381 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C03 compound treatment 1.2164E7 -12100.0 -0.01 1.220548E7 202000.0 0.11 1.19896E7 758376.6666667 0.445299712964343 0.3187 0.6935 2022 HSCI1_000217 CC1(C)C(C=C(Br)Br)C1C(=O)OC(C#N)c2cccc(Oc3ccccc3)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C04 compound treatment 1.291196E7 736000.0 0.41 1.145768E7 -546000.0 -0.31 1.001508E7 -1216143.3333333 -0.714088791308797 -0.3511 -0.3988 3176214 HSCI1_000218 COc1ccc2c(cc(C)c3nnc(SCC(=O)Nc4cccc(c4)C(=O)C)n32)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C05 compound treatment 1.155572E7 -620000.0 -0.35 1.117856E7 -825000.0 -0.46 1.030864E7 -922583.3333333 -0.541717739450917 -0.7821 -0.9849 3054780 HSCI1_000219 CCCCc1c([nH]c2nccnc12)c3ccc(O)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C06 compound treatment 1.046804E7 -1710000.0 -0.96 1.081644E7 -1190000.0 -0.67 1.046248E7 -768743.3333333 -0.451386759011427 -1.2004 -0.9577 3054781 HSCI1_000220 NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+](=O)[O-])cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C07 compound treatment 1.29966E7 821000.0 0.46 1.200496E7 1170.0 0.0 1.211332E7 882096.6666667 0.517944986625118 0.5655 0.8157 360 HSCI1_000221 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C08 compound treatment 9447440.0 -2730000.0 -1.53 9113720.0 -2890000.0 -1.63 8635320.0 -2595903.3333333 -1.52424917593691 -2.7041 -0.9996 2260 HSCI1_000222 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(CO)c8c1c2c(c34)c(c65)c78 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C09 compound treatment 1.18892E7 -287000.0 -0.16 1.11328E7 -871000.0 -0.49 1.105876E7 -172463.3333333 -0.10126613357943 -0.4346 -0.8263 3054782 HSCI1_000223 O=c1cc(oc2c1ccc3ccccc32)N4CCOCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C10 compound treatment 9175200.0 -3000000.0 -1.69 9028080.0 -2980000.0 -1.68 7792280.0 -3438943.3333333 -2.01926106978576 -3.1061 -0.9961 3176215 HSCI1_000224 C1CCC(CC1)n2cnc3c(Nc4ccc(cc4)N5CCOCC5)nc(Oc6cccc7ccccc67)nc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C11 mock treatment 1.27526E7 577000.0 0.32 1.300184E7 998000.0 0.56 1.246164E7 1230416.6666667 0.722469733808444 0.9284 0.9564 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C12 mock treatment 1.262456E7 448000.0 0.25 1.294396E7 940000.0 0.53 1.219944E7 968216.6666667 0.568512485555492 0.7792 0.9543 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C13 mock treatment 1.317376E7 998000.0 0.56 1.35274E7 1520000.0 0.86 1.270228E7 1471056.6666667 0.863767492083006 1.3174 0.9831 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C14 mock treatment 1.306136E7 885000.0 0.5 1.30102E7 1010000.0 0.57 1.241392E7 1182696.6666667 0.694449749496351 1.0151 0.9904 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C15 mock treatment 1.281188E7 636000.0 0.36 1.236184E7 358000.0 0.2 1.190052E7 669296.6666667 0.39299417644881 0.5494 0.9674 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C16 mock treatment 1.254456E7 368000.0 0.21 1.22988E7 295000.0 0.17 1.181852E7 587296.6666667 0.344845837941022 0.4145 0.9525 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C17 compound treatment 1.217472E7 -1350.0 0.0 1.234004E7 336000.0 0.19 1.185588E7 624656.6666667 0.366782690705058 0.3206 0.7768 3176216 HSCI1_000225 CCCCCCCCCCCCCCCCC(=C)OOCC(COP(=O)(ON)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(=O)(O)ON)[C@H](OP(=O)(O)ON)[C@H]1O)OOC(=C)CC/C=C/C/C=C/C\C=C\C\C=C\CCCCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C18 compound treatment 1.244608E7 270000.0 0.15 1.19188E7 -85000.0 -0.05 1.074072E7 -490503.3333333 -0.288011226006465 -0.1063 -0.3232 907140 HSCI1_000226 NCCCCNS(=O)(=O)c1ccc2ccccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C19 compound treatment 1.2237E7 60900.0 0.03 1.221328E7 209000.0 0.12 1.107444E7 -156783.3333333 -0.0920592317769647 0.0347 0.226 3054783 HSCI1_000227 Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=S)(O)O)[C@H](O)[C@@H]3O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C20 compound treatment 7526600.0 -4650000.0 -2.61 7145640.0 -4860000.0 -2.73 6762920.0 -4468303.3333333 -2.62367538352206 -4.6014 -0.9998 2081802 HSCI1_000228 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccc(O)c(CN(C)C)c5cc4Cn3c2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C21 compound treatment 8515320.0 -3660000.0 -2.06 7326080.0 -4680000.0 -2.63 7505440.0 -3725783.3333333 -2.18768630658544 -3.9704 -0.9943 3176218 HSCI1_000229 Nc1nc2n(C3OC4COP(O)(O)OC4C3O)c(Br)nc2c(=O)[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C22 compound treatment 4383600.0 -7790000.0 -4.38 4508720.0 -7500000.0 -4.22 4065880.0 -7165343.3333333 -4.2073094675348 -7.392 -0.9998 3054784 HSCI1_000230 Nc1nc(Cl)nc2n(cnc12)C3C[C@@H](O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C23 compound treatment 8421680.0 -3750000.0 -2.11 6660200.0 -5340000.0 -3.01 8304080.0 -2927143.3333333 -1.71874497651398 -3.9465 -0.9731 1338 HSCI1_000231 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 C24 mock treatment 1.061488E7 -1560000.0 -0.88 1.030356E7 -1700000.0 -0.96 1.009492E7 -1136303.3333333 -0.667208750498288 -1.4441 -0.9894 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D01 mock treatment 1.228056E7 104000.0 0.06 1.131072E7 -693000.0 -0.39 1.1283E7 51776.6666666996 0.030401956993575 -0.1738 -0.4392 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D02 mock treatment 1.267108E7 495000.0 0.28 1.224104E7 237000.0 0.13 1.198984E7 758616.6666667 0.445440634930708 0.4948 0.9132 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D03 compound treatment 6587320.0 -5590000.0 -3.14 5590680.0 -6410000.0 -3.61 9470080.0 -1761143.3333333 -1.03409908992763 -4.4936 -0.9181 3176219 HSCI1_000232 O/N=C/1\C(=C/2\C(=O)Nc3cc(Br)ccc23)\Nc4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D04 compound treatment 7939640.0 -4240000.0 -2.38 7963880.0 -4040000.0 -2.27 7378840.0 -3852383.3333333 -2.26202264384259 -3.9928 -0.9997 3054785 HSCI1_000233 O=C1NC(=O)c2c1ccc(Nc3ccccc3)c2Nc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D05 compound treatment 1.137312E7 -803000.0 -0.45 1.155732E7 -446000.0 -0.25 1.022116E7 -1010063.3333333 -0.593083796190688 -0.7479 -0.9511 1277018 HSCI1_000234 COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D06 compound treatment 1.263596E7 460000.0 0.26 1.355188E7 1550000.0 0.87 1.15518E7 320576.6666667 0.188234559321543 0.7609 0.8198 1919 HSCI1_000235 CCCCCc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D07 compound treatment 1.268512E7 509000.0 0.29 1.230712E7 303000.0 0.17 1.233284E7 1101616.6666667 0.646841611859626 0.6371 0.8757 3176221 HSCI1_000236 C1C[C@H](N/C/2=N/CCCCCCCCCCC2)[C@@H](C1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D08 compound treatment 1.177568E7 -400000.0 -0.22 1.137984E7 -624000.0 -0.35 1.085352E7 -377703.3333333 -0.221777901815264 -0.4607 -0.9752 3054786 HSCI1_000237 OCC1OC([C@@H](O)[C@H]1O)n2cnc3cc(Cl)c(Cl)cc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D09 compound treatment 1.085544E7 -1320000.0 -0.74 1.09106E7 -1090000.0 -0.62 9711240.0 -1519983.3333333 -0.892496000725947 -1.2988 -0.9888 3176222 HSCI1_000238 COc1cc2ncnc(Nc3ccc(OCc4ccccc4)cc3)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D10 compound treatment 1.288132E7 705000.0 0.4 1.311632E7 1110000.0 0.63 1.247992E7 1248696.6666667 0.733203290246521 1.0136 0.9723 407 HSCI1_000239 [O-][N+](=O)c1cccc2c(Br)n[nH]c12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D11 mock treatment 1.307608E7 900000.0 0.51 1.21992E7 195000.0 0.11 1.18058E7 574576.6666667 0.337376973723716 0.5502 0.8907 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D12 mock treatment 1.33208E7 1140000.0 0.64 1.376084E7 1760000.0 0.99 1.350528E7 2274056.6666667 1.33526890454342 1.7132 0.9615 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D13 mock treatment 1.527284E7 3100000.0 1.74 1.271624E7 712000.0 0.4 1.158768E7 356456.6666667 0.209302393293 1.3566 0.7548 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D14 mock treatment 1.302352E7 847000.0 0.48 1.246988E7 466000.0 0.26 1.293624E7 1705016.6666667 1.00114292229376 1.0043 0.8816 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D15 mock treatment 1.254332E7 367000.0 0.21 1.24602E7 456000.0 0.26 1.178392E7 552696.6666667 0.324529587790175 0.4548 0.9834 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D16 mock treatment 1.324416E7 1070000.0 0.6 1.252632E7 523000.0 0.29 1.153944E7 308216.6666667 0.180977078053784 0.6207 0.8966 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D17 compound treatment 1.203168E7 -144000.0 -0.08 1.10624E7 -941000.0 -0.53 1.236408E7 1132856.6666667 0.665184954481373 0.0313 0.0366 3054787 HSCI1_000240 N/N=C(/N)\NO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D18 compound treatment 1.219276E7 16700.0 0.01 1.236276E7 359000.0 0.2 1.273204E7 1500816.6666667 0.881241815912174 0.6309 0.6977 907294 HSCI1_000241 CN(C)C(=N)NCCC[C@H](N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D19 compound treatment 1.154704E7 -629000.0 -0.35 1.266948E7 666000.0 0.37 1.147464E7 243416.6666667 0.142928147135435 0.0949 0.1775 3176223 HSCI1_000242 CSC(=N)NCCC[C@H](N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D20 compound treatment 1.205876E7 -117000.0 -0.07 1.26782E7 674000.0 0.38 1.14842E7 252976.6666667 0.148541538795611 0.2669 0.6463 3054789 HSCI1_000243 CNC(=N)NCCC[C@@H](N)C=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D21 compound treatment 1.199016E7 -186000.0 -0.1 1.19428E7 -61000.0 -0.03 1.080696E7 -424263.3333333 -0.24911676328993 -0.2239 -0.8224 3176224 HSCI1_000244 OP(=O)(O)C(Cl)(Cl)P(=O)(O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D22 compound treatment 1.245004E7 274000.0 0.15 1.11862E7 -818000.0 -0.46 1.100548E7 -225743.3333333 -0.132550810112295 -0.2534 -0.5037 3176225 HSCI1_000245 CNC(=N)NCCC[C@H](N)C=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D23 compound treatment 1.160452E7 -572000.0 -0.32 1.204436E7 40600.0 0.02 1.069464E7 -536583.3333333 -0.315068243548402 -0.3541 -0.7861 2215 HSCI1_000246 CCCNC(=N)NCCCC(N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 D24 mock treatment 1.073936E7 -1440000.0 -0.81 1.107448E7 -929000.0 -0.52 1.108324E7 -147983.3333333 -0.0868920930102753 -0.8181 -0.8472 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E01 mock treatment 1.146E7 -716000.0 -0.4 1.168072E7 -323000.0 -0.18 1.179452E7 563296.6666667 0.330753641304596 -0.1463 -0.2651 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E02 mock treatment 1.315628E7 980000.0 0.55 1.262048E7 617000.0 0.35 1.200168E7 770456.6666667 0.452392785271344 0.7795 0.9834 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E03 mock treatment 1.233648E7 160000.0 0.09 1.2034E7 30200.0 0.02 1.205156E7 820336.6666667 0.481681067280716 0.3399 0.6933 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E04 mock treatment 1.24312E7 255000.0 0.14 1.212728E7 123000.0 0.07 1.178304E7 551816.6666667 0.324012873913506 0.3099 0.8584 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E05 compound treatment 1.096128E7 -1210000.0 -0.68 1.061568E7 -1390000.0 -0.78 9929160.0 -1302063.3333333 -0.764538855267202 -1.2865 -0.9983 3176226 HSCI1_000247 CCCCc1c([nH]c2nccnc12)c3ccc(OC)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E06 compound treatment 1.342136E7 1250000.0 0.7 1.2436E7 432000.0 0.24 1.21624E7 931176.6666667 0.546763528746609 0.86 0.9342 2371 HSCI1_000248 CCCCCCCCNC(=O)C(Cc1ccc(OCc2ccncc2)cc1)NC(=O)C3CCC(CN)CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E07 compound treatment 1.07964E7 -1380000.0 -0.77 9278440.0 -2730000.0 -1.53 9592520.0 -1638703.3333333 -0.962205400087467 -1.8887 -0.9588 1989 HSCI1_000249 Clc1[nH]c2ccccc2c1/C=C\3/C(=O)Nc4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E08 compound treatment 1.127112E7 -905000.0 -0.51 9071080.0 -2930000.0 -1.65 9224800.0 -2006423.3333333 -1.1781213395519 -1.9268 -0.9215 1416171 HSCI1_000250 OC(CN1CCNCC1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E09 mock treatment 1.263536E7 459000.0 0.26 1.2379E7 375000.0 0.21 1.189412E7 662896.6666667 0.389236257345763 0.4956 0.967 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E10 mock treatment 1.323368E7 1060000.0 0.59 1.278916E7 785000.0 0.44 1.210044E7 869216.6666667 0.510382174430236 0.8929 0.9928 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E11 compound treatment 1.33508E7 1170000.0 0.66 1.3389E7 1390000.0 0.78 1.248356E7 1252336.6666667 0.735340606736379 1.2557 0.9977 663 HSCI1_000251 Fc1ccc(cc1)c2nc3SCCn3c2c4ccncc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E12 compound treatment 3687440.0 -8490000.0 -4.77 4527440.0 -7480000.0 -4.21 4155640.0 -7075583.3333333 -4.15460465211457 -7.5812 -0.998 1000089 HSCI1_000252 COC1C(C)OC(OC2CC(C)(O)C(C(=O)OC)c3cc4C(=O)c5c6OC7OC(C)(C(O)C(C7O)N(C)C)c6cc(O)c5C(=O)c4c(O)c23)C(OC)C1(C)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E13 compound treatment 1.388824E7 1710000.0 0.96 1.261188E7 608000.0 0.34 1.125788E7 26656.6666666996 0.0156521245141161 0.7619 0.7463 3054791 HSCI1_000253 Nc1nc2n(cnc2c(=O)[nH]1)C3OC4COP(O)(O)OC4C3O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E14 compound treatment 1.262812E7 452000.0 0.25 1.2718E7 714000.0 0.4 1.202624E7 795016.6666667 0.466813799829287 0.6482 0.9728 3176276 HSCI1_000254 NCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N[N+](=O)[O-])C(=O)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E15 mock treatment 1.167188E7 -504000.0 -0.28 1.239716E7 393000.0 0.22 1.195924E7 728016.6666667 0.427473084219265 0.2111 0.378 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E16 mock treatment 1.23316E7 156000.0 0.09 1.23068E7 303000.0 0.17 1.102116E7 -210063.3333333 -0.12334390830983 0.0777 0.3409 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E17 mock treatment 1.188824E7 -288000.0 -0.16 1.233784E7 334000.0 0.19 1.120024E7 -30983.3333333004 -0.0181926344076998 0.0047 0.019 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E18 mock treatment 1.23574E7 181000.0 0.1 1.181392E7 -190000.0 -0.11 1.062292E7 -608303.3333333 -0.357180424496921 -0.2091 -0.5411 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E19 compound treatment 1.313224E7 956000.0 0.54 1.23364E7 333000.0 0.19 1.106296E7 -168263.3333333 -0.0987999991680551 0.3611 0.6256 1000095 HSCI1_000255 CC(O)C(O)[C@H]1CNc2nc(N)[nH]c(=O)c2N1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E20 compound treatment 1.233264E7 157000.0 0.09 1.224664E7 243000.0 0.14 1.117692E7 -54303.3333333004 -0.0318855521394268 0.1113 0.6719 3054834 HSCI1_000256 NCCNC[C@@H](N)CCCNC(=N)N[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E21 compound treatment 1.20066E7 -169000.0 -0.1 1.110716E7 -897000.0 -0.5 1.079948E7 -431743.3333333 -0.253508831241616 -0.4927 -0.8602 423 HSCI1_000257 COC(=O)[C@@H](N)CCCNC(=N)N[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E22 compound treatment 1.178196E7 -394000.0 -0.22 1.12138E7 -790000.0 -0.44 1.0573E7 -658223.3333333 -0.386492193500687 -0.6077 -0.9655 2114444 HSCI1_000258 O=c1n(CCN2CCCCC2)c(=O)c3ccc4c5ccc6c(=O)n(CCN7CCCCC7)c(=O)c8ccc(c9ccc1c3c94)c5c86 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E23 compound treatment 1.144088E7 -735000.0 -0.41 1.10768E7 -927000.0 -0.52 1.070004E7 -531183.3333333 -0.311897499305206 -0.7198 -0.9794 832002 HSCI1_000259 CC(=N)NCCC[C@H](N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 E24 mock treatment 1.052688E7 -1650000.0 -0.93 1.04238E7 -1580000.0 -0.89 1.028356E7 -947663.3333333 -0.556444084935981 -1.3696 -0.9786 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F01 mock treatment 1.187424E7 -302000.0 -0.17 1.186836E7 -135000.0 -0.08 1.110116E7 -130063.3333333 -0.0763699195217441 -0.186 -0.9255 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F02 mock treatment 1.252068E7 345000.0 0.19 1.196264E7 -41200.0 -0.02 1.17304E7 499176.6666667 0.293103989290945 0.2676 0.7602 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F03 mock treatment 1.255224E7 376000.0 0.21 1.233212E7 328000.0 0.18 1.144348E7 212256.6666667 0.124631778502475 0.3006 0.9789 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F04 mock treatment 1.278648E7 610000.0 0.34 1.274276E7 739000.0 0.42 1.167476E7 443536.6666667 0.260433580088831 0.5885 0.983 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F05 compound treatment 1.221524E7 39200.0 0.02 1.222736E7 224000.0 0.13 1.219332E7 962096.6666667 0.564918975413204 0.4115 0.7105 3176278 HSCI1_000260 CC(=O)O/N=C/1\C(=C/2\C(=O)Nc3cc(Br)ccc23)\Nc4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F06 compound treatment 1.40096E7 1830000.0 1.03 1.28046E7 801000.0 0.45 1.229504E7 1063816.6666667 0.624646402157255 1.2155 0.9451 1505 HSCI1_000261 CC(C)Cn1c(=O)n(C)c(=O)c2[nH]cnc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F07 compound treatment 1.101716E7 -1160000.0 -0.65 7930000.0 -4070000.0 -2.29 8426120.0 -2805103.3333333 -1.64708615661776 -2.6507 -0.9148 3054836 HSCI1_000262 COc1ccc(CNc2nc(nc3n(cnc23)C(C)C)N(CCO)CCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F08 compound treatment 2461160.0 -9710000.0 -5.46 538200.0 -1.15E7 -6.45 999440.0 -1.02317833333333E7 -6.00784594477653 -10.3453 -0.9977 1980 HSCI1_000263 CC1(C2CCC(O2)C1(C)C(=O)O)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F09 mock treatment 1.24738E7 298000.0 0.17 1.252896E7 525000.0 0.3 1.157236E7 341136.6666667 0.200306874440082 0.3829 0.971 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F10 mock treatment 1.343408E7 1260000.0 0.71 1.303756E7 1030000.0 0.58 1.25672E7 1335976.6666667 0.784451912014323 1.1968 0.9928 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F11 compound treatment 1.301892E7 843000.0 0.47 1.287592E7 872000.0 0.49 1.241896E7 1187736.6666667 0.69740911079 0.9594 0.9836 832084 HSCI1_000264 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c4nc[nH]c4n2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F12 compound treatment 1.293048E7 754000.0 0.42 1.378308E7 1780000.0 1.0 1.292008E7 1688856.6666667 0.99165417655857 1.3954 0.9481 445 HSCI1_000265 NC(=O)c1cccc(N)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F13 compound treatment 1.27234E7 547000.0 0.31 1.266848E7 665000.0 0.37 1.20732E7 841976.6666667 0.494387531247893 0.6789 0.9811 2194 HSCI1_000266 OS(=O)(=O)c1cc(c2c(NC(=O)c3cccc(c3)[N+](=O)[O-])ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F14 compound treatment 1.258048E7 404000.0 0.23 1.276036E7 757000.0 0.43 1.183452E7 603296.6666667 0.354240635698639 0.5815 0.9713 2025 HSCI1_000267 NCCCC(N)(C(F)F)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F15 mock treatment 1.291336E7 737000.0 0.41 1.28858E7 882000.0 0.5 1.151588E7 284656.6666667 0.167143238355693 0.6222 0.9318 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F16 mock treatment 1.293584E7 760000.0 0.43 1.301728E7 1010000.0 0.57 1.178828E7 557056.6666667 0.327089670179125 0.7646 0.9753 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F17 mock treatment 1.263348E7 457000.0 0.26 1.307796E7 1070000.0 0.6 1.175636E7 525136.6666667 0.308347048652679 0.6755 0.9307 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F18 mock treatment 1.246952E7 293000.0 0.16 1.243108E7 427000.0 0.24 1.112588E7 -105343.3333333 -0.0618549569862255 0.1983 0.6653 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F19 compound treatment 1.036024E7 -1820000.0 -1.02 1.02278E7 -1780000.0 -1.0 8926160.0 -2305063.3333333 -1.35347523969783 -1.9475 -0.9898 2259 HSCI1_000268 CN1CCc2cc3OCOc3cc2C(=O)Cc4ccc5OCOc5c4C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F20 compound treatment 1.210308E7 -73000.0 -0.04 1.190352E7 -100000.0 -0.06 1.123988E7 8656.66666669957 0.00508297703679678 -0.0533 -0.7623 2674 HSCI1_000269 N[C@@H](CCC(=O)O)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F21 compound treatment 6420880.0 -5760000.0 -3.23 6558200.0 -5450000.0 -3.07 5915280.0 -5315943.3333333 -3.12138828172623 -5.4383 -0.9998 3176279 HSCI1_000270 CC[C@]1(O)C[C@H]2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)[C@@H]7[C@@]86CCN9CC=C[C@@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F22 compound treatment 1.172644E7 -450000.0 -0.25 1.168944E7 -314000.0 -0.18 1.065404E7 -577183.3333333 -0.338907542858356 -0.4436 -0.9682 2129 HSCI1_000271 OCC(O)C1OC(=O)C(=C1O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F23 compound treatment 768880.0 -1.14E7 -6.41 641560.0 -1.14E7 -6.4 515040.0 -1.07161833333333E7 -6.29227344688839 -11.0247 -1.0 1000078 HSCI1_000272 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](OC5CC(N)C(O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 F24 mock treatment 1.09176E7 -1260000.0 -0.71 1.044712E7 -1560000.0 -0.88 9745240.0 -1485983.3333333 -0.872532055491011 -1.4178 -0.9954 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G01 mock treatment 1.183468E7 -341000.0 -0.19 1.170312E7 -301000.0 -0.17 1.096892E7 -262303.3333333 -0.15401792298845 -0.2973 -0.9959 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G02 compound treatment 1.163032E7 -546000.0 -0.31 9803000.0 -2200000.0 -1.24 8920240.0 -2310983.3333333 -1.35695131486815 -1.6757 -0.8995 25 HSCI1_000273 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)OCC[N+](C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G03 mock treatment 1.256636E7 390000.0 0.22 1.194796E7 -55800.0 -0.03 1.199408E7 762856.6666667 0.447930256336476 0.367 0.7345 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G04 mock treatment 1.281992E7 644000.0 0.36 1.263324E7 629000.0 0.35 1.111488E7 -116343.3333333 -0.0683138804445873 0.3739 0.7319 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G05 mock treatment 1.275944E7 583000.0 0.33 1.222248E7 219000.0 0.12 1.165832E7 427096.6666667 0.25078042539288 0.405 0.9407 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G06 mock treatment 1.317124E7 995000.0 0.56 1.233428E7 330000.0 0.19 1.048624E7 -744983.3333333 -0.437435484341366 0.1776 0.242 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G07 compound treatment 1.339548E7 1220000.0 0.68 1.331436E7 1310000.0 0.74 1.222624E7 995016.6666667 0.584248771799501 1.1587 0.9955 3054838 HSCI1_000274 CC(C)(c1ccc(NS(=O)(=O)C(F)(F)F)cc1)c2ccc(cc2)C(C)(C)c3cccc(NS(=O)(=O)C(F)(F)F)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G08 compound treatment 1.301604E7 840000.0 0.47 1.300708E7 1000000.0 0.56 1.199684E7 765616.6666667 0.449550858949665 0.858 0.995 546 HSCI1_000275 Cc1ncc2ccccc2c1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G09 compound treatment 7864760.0 -4310000.0 -2.42 7281880.0 -4720000.0 -2.66 6875080.0 -4356143.3333333 -2.55781785124117 -4.4095 -0.9993 1947905 HSCI1_000276 Clc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G10 compound treatment 1.318324E7 1010000.0 0.57 1.29538E7 950000.0 0.53 1.173944E7 508216.6666667 0.298412050023999 0.8076 0.9688 636 HSCI1_000277 C/C(=C(\C#N)/C(=O)Nc1cccc(F)c1)/O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G11 compound treatment 1.334728E7 1170000.0 0.66 1.201936E7 15600.0 0.01 1.108608E7 -145143.3333333 -0.0852245164082983 0.3357 0.506 3176281 HSCI1_000278 COc1ccc(CNC(=O)Nc2ncc(s2)[N+](=O)[O-])cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G12 compound treatment 1.291228E7 736000.0 0.41 1.336424E7 1360000.0 0.77 1.269612E7 1464896.6666667 0.860150494946323 1.1775 0.9623 3054840 HSCI1_000279 CC1OC(C[C@H]1O)n2cnc3c(N)ncnc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G13 compound treatment 563120.0 -1.16E7 -6.52 608200.0 -1.14E7 -6.41 871720.0 -1.03595033333333E7 -6.0828399178767 -10.9814 -0.9996 2319 HSCI1_000280 CN(C)CC1Cc2ccccc2C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G14 compound treatment 1.355856E7 1380000.0 0.78 1.263016E7 626000.0 0.35 1.219968E7 968456.6666667 0.568653407521857 0.9802 0.9563 3176282 HSCI1_000281 N[C@@H](CCN/C(=N/O)/N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G15 compound treatment 1.269472E7 519000.0 0.29 1.287628E7 872000.0 0.49 1.2386E7 1154776.6666667 0.678055827409309 0.8432 0.9512 2145 HSCI1_000282 NC(=N)NCCS 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G16 compound treatment 1.330172E7 1130000.0 0.63 1.33948E7 1390000.0 0.78 1.211076E7 879536.6666667 0.516441818983899 1.1153 0.9859 3583 HSCI1_000283 Cn1cc(NC(=O)c2cc(NC(=O)CNC(=N)N)cn2C)cc1C(=O)NCCC(=N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G17 mock treatment 1.270444E7 528000.0 0.3 1.250244E7 499000.0 0.28 1.191392E7 682696.6666667 0.400862319570814 0.5648 0.9869 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G18 mock treatment 1.24364E7 260000.0 0.15 1.2857E7 853000.0 0.48 1.137592E7 144696.6666667 0.0849622449709368 0.4108 0.8067 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G19 mock treatment 1.255128E7 375000.0 0.21 1.188384E7 -120000.0 -0.07 1.091652E7 -314703.3333333 -0.184785885644646 -0.024 -0.0832 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G20 mock treatment 1.232936E7 153000.0 0.09 1.25738E7 570000.0 0.32 1.147664E7 245416.6666667 0.144102496855137 0.3182 0.8786 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G21 compound treatment 1.015844E7 -2020000.0 -1.13 1.060016E7 -1400000.0 -0.79 1.011172E7 -1119503.3333333 -0.65734421285279 -1.49 -0.9739 1030173 HSCI1_000284 NC(=N)NO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G22 compound treatment 5241160.0 -6930000.0 -3.9 5836760.0 -6170000.0 -3.47 3229880.0 -8001343.3333333 -4.6981876503703 -6.9657 -0.9921 3176283 HSCI1_000285 COc1cc(ccc1[n+]2nc(nn2c3ccc(cc3)[N+](=O)[O-])c4ccccc4)c5ccc(c(OC)c5)[n+]6nc(nn6c7ccc(cc7)[N+](=O)[O-])c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G23 compound treatment 1.194836E7 -228000.0 -0.13 1.157816E7 -426000.0 -0.24 1.045668E7 -774543.3333333 -0.454792373198564 -0.4747 -0.8962 469 HSCI1_000286 CCCC(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 G24 mock treatment 1.146372E7 -712000.0 -0.4 1.171948E7 -284000.0 -0.16 1.082564E7 -405583.3333333 -0.238148336907912 -0.4609 -0.9361 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H01 mock treatment 1.238184E7 206000.0 0.12 1.164248E7 -361000.0 -0.2 1.169856E7 467336.6666667 0.274408341753287 0.1077 0.2988 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H02 compound treatment 1.28496E7 674000.0 0.38 1.239856E7 395000.0 0.22 1.190692E7 675696.6666667 0.396752095551857 0.5758 0.9734 1594 HSCI1_000287 N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H03 mock treatment 1.209652E7 -79600.0 -0.04 1.243176E7 428000.0 0.24 1.173984E7 508616.6666667 0.298646919967939 0.2857 0.7396 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H04 mock treatment 1.268588E7 510000.0 0.29 1.25844E7 581000.0 0.33 1.202524E7 794016.6666667 0.466226624969436 0.6232 0.9778 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H05 mock treatment 1.278444E7 608000.0 0.34 1.270128E7 697000.0 0.39 1.165988E7 428656.6666667 0.251696418174247 0.5693 0.9846 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H06 mock treatment 1.346208E7 1290000.0 0.72 1.244268E7 439000.0 0.25 1.150076E7 269536.6666667 0.158265154474745 0.651 0.8351 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H07 compound treatment 1.290952E7 733000.0 0.41 1.20702E7 66400.0 0.04 1.086676E7 -364463.3333333 -0.214003706670836 0.1359 0.2917 3054842 HSCI1_000288 CSc1nc(c([nH]1)c2ccnc(NC(C)c3ccccc3)c2)c4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H08 compound treatment 1.329128E7 1120000.0 0.63 1.189016E7 -114000.0 -0.06 1.124132E7 10096.6666666996 0.00592850883498232 0.3281 0.5211 1961 HSCI1_000289 CC(C)(C)c1cc(O)c(cc1O)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H09 compound treatment 1.188036E7 -296000.0 -0.17 9364480.0 -2640000.0 -1.49 9456600.0 -1774623.3333333 -1.04201420703842 -1.5553 -0.8535 572 HSCI1_000290 CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H10 compound treatment 1.30948E7 919000.0 0.52 1.323656E7 1230000.0 0.69 1.236164E7 1130416.6666667 0.663752247823336 1.0818 0.9923 1907755 HSCI1_000291 COCc1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H11 compound treatment 1.257112E7 395000.0 0.22 1.302604E7 1020000.0 0.58 1.091096E7 -320263.3333333 -0.188050577865418 0.3518 0.5456 574 HSCI1_000292 NCCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H12 compound treatment 7756880.0 -4420000.0 -2.48 8458240.0 -3550000.0 -2.0 7133560.0 -4097663.3333333 -2.40604489346686 -3.9745 -0.9957 3176284 HSCI1_000293 COc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H13 compound treatment 1.33002E7 1120000.0 0.63 1.295288E7 949000.0 0.53 1.224712E7 1015896.6666667 0.596508982873192 1.0174 0.9977 2195 HSCI1_000294 OS(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc5ccc(c6cc(cc(c56)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c3)ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H14 compound treatment 1.764028E7 5460000.0 3.07 1.227752E7 274000.0 0.15 1.1952E7 720776.6666667 0.423221938233943 2.1053 0.6787 1714 HSCI1_000295 CN(C)C(=N)NC(=N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H15 compound treatment 1.250656E7 330000.0 0.19 1.276772E7 764000.0 0.43 1.184532E7 614096.6666667 0.36058212418503 0.5636 0.9535 2197 HSCI1_000296 OS(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc4ccc(cc4S(=O)(=O)O)S(=O)(=O)O)C(=O)Nc5ccc(cc5S(=O)(=O)O)S(=O)(=O)O)cc(c2)C(=O)Nc6ccc(cc6S(=O)(=O)O)S(=O)(=O)O)c(c1)S(=O)(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H16 compound treatment 1.261752E7 441000.0 0.25 1.27402E7 736000.0 0.41 1.149564E7 264416.6666667 0.155258819192307 0.4721 0.9305 3054849 HSCI1_000297 CCNC(=N)NCCC[C@H](N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H17 mock treatment 1.245632E7 280000.0 0.16 1.203708E7 33300.0 0.02 1.126708E7 35856.6666666996 0.021054133224746 0.1139 0.712 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H18 mock treatment 1.290672E7 731000.0 0.41 1.325472E7 1250000.0 0.7 1.157588E7 344656.6666667 0.202373729946757 0.7603 0.9054 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H19 mock treatment 1.233048E7 154000.0 0.09 1.225396E7 250000.0 0.14 1.062144E7 -609783.3333333 -0.358049443289501 -0.0753 -0.191 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H20 mock treatment 1.291644E7 740000.0 0.42 1.253004E7 526000.0 0.3 1.117508E7 -56143.3333333004 -0.0329659538815528 0.3921 0.7663 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H21 compound treatment 2339760.0 -9840000.0 -5.52 2601840.0 -9400000.0 -5.29 2385040.0 -8846183.3333333 -5.19425645896688 -9.2443 -0.9997 3054896 HSCI1_000298 NC(=O)c1cn(C2OC(CO)[C@H](O)[C@@H]2O)c3ncnc(N)c13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H22 compound treatment 1.021184E7 -1960000.0 -1.1 1.065976E7 -1340000.0 -0.76 9711720.0 -1519503.3333333 -0.892214156793219 -1.5889 -0.9881 2063 HSCI1_000299 CCOC(=O)c1cnc2n(CC)ncc2c1NN=C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H23 compound treatment 6940760.0 -5240000.0 -2.94 6943880.0 -5060000.0 -2.85 6469560.0 -4761663.3333333 -2.79592900040797 -4.9564 -0.9998 606 HSCI1_000300 CNCCNS(=O)(=O)c1cccc2cnccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 H24 mock treatment 1.127784E7 -898000.0 -0.5 1.160892E7 -395000.0 -0.22 1.044164E7 -789583.3333333 -0.463623483090724 -0.6873 -0.9541 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I01 mock treatment 1.11698E7 -1010000.0 -0.57 1.188264E7 -121000.0 -0.07 1.062904E7 -602183.3333333 -0.353586914354633 -0.5698 -0.8503 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I02 compound treatment 1.268332E7 507000.0 0.28 1.247072E7 467000.0 0.26 1.232588E7 1094656.6666667 0.642754874835062 0.6873 0.9157 662 HSCI1_000301 Cc1nc(c(o1)c2ccncc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I03 compound treatment 1.188524E7 -291000.0 -0.16 1.209212E7 88300.0 0.05 1.12248E7 -6423.33333330043 -0.0037716198497574 -0.0678 -0.3969 3054901 HSCI1_000302 Clc1cc(Cl)c(NC(=O)Nc2ccncc2)c(Cl)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I04 compound treatment 1.278452E7 608000.0 0.34 1.13172E7 -687000.0 -0.39 9769280.0 -1461943.3333333 -0.858416371860191 -0.5214 -0.5206 2110413 HSCI1_000303 Cc1cc(C)c(/C=C/2\C(=O)Nc3ccccc23)[nH]1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I05 mock treatment 1.197788E7 -198000.0 -0.11 1.198392E7 -19900.0 -0.01 1.047472E7 -756503.3333333 -0.44419973872685 -0.3272 -0.7143 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I06 mock treatment 1.27218E7 546000.0 0.31 1.241524E7 411000.0 0.23 1.134672E7 115496.6666667 0.0678167390632854 0.3498 0.8967 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I07 mock treatment 1.299184E7 816000.0 0.46 1.211608E7 112000.0 0.06 1.221136E7 980136.6666667 0.575511609884917 0.6333 0.8577 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I08 mock treatment 1.476852E7 2590000.0 1.46 1.258104E7 577000.0 0.32 1.164852E7 417296.6666667 0.245026111766339 1.1698 0.7737 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I09 compound treatment 1.287544E7 699000.0 0.39 1.225328E7 249000.0 0.14 1.127064E7 39416.6666666996 0.0231444757258158 0.3212 0.7689 2023 HSCI1_000304 CCCCn1c(=O)n(CCCC)c2ncn(CC(=O)C)c2c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I10 compound treatment 1.555812E7 3380000.0 1.9 1.257004E7 566000.0 0.32 1.1621E7 389776.6666667 0.228867059623238 1.4129 0.7284 2196 HSCI1_000305 OS(=O)(=O)c1cc(c2c(NC(=O)c3ccc(NC(=O)c4ccc(NC(=O)Nc5ccc(cc5)C(=O)Nc6ccc(cc6)C(=O)Nc7ccc(c8cc(cc(c78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)cc4)cc3)ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I11 compound treatment 8362160.0 -3810000.0 -2.14 7207400.0 -4800000.0 -2.7 6433040.0 -4798183.3333333 -2.81737262628973 -4.4222 -0.9934 3054905 HSCI1_000306 Oc1ccc(cc1O)C(=O)/C(=C/c2ccc3oc(=O)[nH]c3c2)/C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I12 compound treatment 1.060624E7 -1570000.0 -0.88 1.181148E7 -192000.0 -0.11 1.127692E7 45696.6666666996 0.0268319338456805 -0.5561 -0.6257 3054907 HSCI1_000307 Cc1nc2cc3nc(cnc3cc2n1C)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I13 compound treatment 1.266808E7 492000.0 0.28 1.318184E7 1180000.0 0.66 1.113388E7 -97343.3333333004 -0.057157558107417 0.5094 0.7068 3479224 HSCI1_000308 CC(=N)NCCCCC(N)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I14 compound treatment 7132000.0 -5040000.0 -2.83 6304080.0 -5700000.0 -3.21 5679640.0 -5551583.3333333 -3.25975016570153 -5.3701 -0.9981 2061 HSCI1_000309 Oc1cc(c2cc(ccc2c1N=Nc3ccc4ccccc4c3O)[N+](=O)[O-])S(=O)(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I15 compound treatment 1.242988E7 254000.0 0.14 1.24362E7 432000.0 0.24 1.117888E7 -52343.3333333004 -0.0307346894141187 0.2051 0.7228 2087 HSCI1_000310 NC(CCC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I16 compound treatment 1.30062E7 830000.0 0.47 1.156676E7 -437000.0 -0.25 1.16012E7 369976.6666667 0.217240997398186 0.2526 0.443 1870 HSCI1_000311 NC(=N)SCCc1cccc(CCSC(=N)N)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I17 compound treatment 1.181916E7 -357000.0 -0.2 1.263932E7 636000.0 0.36 5931360.0 -5299863.3333333 -3.11194650997982 -1.7059 -0.5435 2408 HSCI1_000312 NCCC(O)(P(=O)(O)O)P(=O)(O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I18 compound treatment 1.036344E7 -1810000.0 -1.02 9989120.0 -2010000.0 -1.13 8993040.0 -2238183.3333333 -1.31420498507099 -2.0013 -0.9945 3054955 HSCI1_000313 Cc1ccc(cc1)S(=O)(=O)N[C@H](CCCCN)C(=O)CCl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I19 mock treatment 1.231072E7 135000.0 0.08 1.380452E7 1800000.0 1.01 1.260552E7 1374296.6666667 0.806952452643816 1.0948 0.8436 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I20 mock treatment 1.202024E7 -156000.0 -0.09 1.229416E7 290000.0 0.16 1.09756E7 -255623.3333333 -0.150095594924645 -0.0428 -0.1795 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I21 mock treatment 1.179524E7 -381000.0 -0.21 1.14538E7 -550000.0 -0.31 9526400.0 -1704823.3333333 -1.00102940182082 -0.8802 -0.8231 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I22 mock treatment 1.164844E7 -528000.0 -0.3 1.19888E7 -15000.0 -0.01 1.063992E7 -591303.3333333 -0.347198451879453 -0.3764 -0.8245 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I23 compound treatment 1.179272E7 -383000.0 -0.22 1.161712E7 -387000.0 -0.22 1.062868E7 -602543.3333333 -0.353798297304179 -0.4542 -0.9709 1956 HSCI1_000314 N[C@H](CSCCB(O)O)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 I24 mock treatment 1.083936E7 -1340000.0 -0.75 1.118684E7 -817000.0 -0.46 1.069156E7 -539663.3333333 -0.316876742116744 -0.8819 -0.9425 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J01 mock treatment 1.2221E7 44900.0 0.03 1.098808E7 -1020000.0 -0.57 1.039496E7 -836263.3333333 -0.491032805548572 -0.599 -0.7944 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J02 compound treatment 6229720.0 -5950000.0 -3.34 5729000.0 -6270000.0 -3.53 5203160.0 -6028063.3333333 -3.53952724292337 -6.0112 -0.9996 1005830 HSCI1_000315 Cc1cc(ccc1N=Nc2cc(c3ccccc3c2N)S(=O)(=O)O)c4ccc(N=Nc5cc(c6ccccc6c5N)S(=O)(=O)O)c(C)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J03 compound treatment 7920920.0 -4260000.0 -2.39 7304960.0 -4700000.0 -2.65 6955560.0 -4275663.3333333 -2.51056201852035 -4.3565 -0.9991 573 HSCI1_000316 CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J04 compound treatment 4207240.0 -7970000.0 -4.48 3341520.0 -8660000.0 -4.88 2694200.0 -8537023.3333333 -5.01272547929532 -8.2935 -0.9989 1038990 HSCI1_000317 FC(F)(F)c1ccc2Sc3ccccc3N(CCCN4CCN(CCCl)CC4)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J05 mock treatment 1.363528E7 1460000.0 0.82 1.18426E7 -161000.0 -0.09 1.129028E7 59056.6666666996 0.0346765899732909 0.4408 0.5341 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J06 mock treatment 1.446108E7 2290000.0 1.28 1.24056E7 402000.0 0.23 1.08254E7 -405823.3333333 -0.238289258874276 0.734 0.554 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J07 mock treatment 1.323964E7 1060000.0 0.6 1.24584E7 455000.0 0.26 1.16886E7 457376.6666667 0.26856008014917 0.6477 0.9211 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J08 mock treatment 1.298276E7 807000.0 0.45 1.235676E7 353000.0 0.2 1.167128E7 440056.6666667 0.25839021157655 0.5255 0.9415 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J09 compound treatment 1.218012E7 4050.0 0.0 1.105852E7 -945000.0 -0.53 1.128136E7 50136.6666666996 0.0294389902234193 -0.2889 -0.5421 3054961 HSCI1_000318 OCc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J10 compound treatment 1.317356E7 997000.0 0.56 1.118556E7 -818000.0 -0.46 1.131284E7 81616.6666666996 0.0479232548115311 0.0852 0.1172 1979 HSCI1_000319 Clc1ccc(cc1)C(c2ccc(Cl)cc2)[n+]3ccn(CC(OCc4ccc(Cl)cc4Cl)c5ccc(Cl)cc5Cl)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J11 compound treatment 1.283196E7 656000.0 0.37 1.186016E7 -144000.0 -0.08 1.067292E7 -558303.3333333 -0.327821681504368 -0.0233 -0.0465 580 HSCI1_000320 Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCN)c4ccccc34)c5ccccc15 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J12 compound treatment 1.289756E7 721000.0 0.41 1.216812E7 164000.0 0.09 1.245344E7 1222216.6666667 0.717654899957665 0.7017 0.8461 3054964 HSCI1_000321 CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CCC[C@]2(C)C3C(=O)C[C@@](C)(O[C@]13C)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J13 compound treatment 1.218736E7 11300.0 0.01 1.147592E7 -528000.0 -0.3 1.236588E7 1134656.6666667 0.666241869229105 0.2168 0.2971 907101 HSCI1_000322 NCCCCNS(=O)(=O)c1ccc2c(Cl)cccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J14 compound treatment 1.304324E7 867000.0 0.49 1.272616E7 722000.0 0.41 1.153676E7 305536.6666667 0.179403449429383 0.6196 0.9396 3176334 HSCI1_000323 CC(C)[C@@]1(C)[C@@H]([C@H](OO)c2ccc[nH]2)[C@]3(O)[C@]4(O)[C@@]1(C)[C@@]5(O)C[C@@]3(C)[C@@]6(O)CCC(=C)[C@@H](O)[C@]46O5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J15 compound treatment 8208880.0 -3970000.0 -2.23 8136880.0 -3870000.0 -2.18 7795200.0 -3436023.3333333 -2.017546519195 -3.7081 -0.9991 3054966 HSCI1_000324 C[C@@H]1CNCCCN1S(=O)(=O)c2cccc3cncc(C)c23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J16 compound treatment 1.11134E7 -1060000.0 -0.6 9831440.0 -2170000.0 -1.22 9780000.0 -1451223.3333333 -0.852121857362588 -1.5426 -0.9608 3176335 HSCI1_000325 CN1CCN(CCCC(=O)O[C@H]2[C@@H](O)[C@H]3C(C)(C)CC[C@H](O)[C@]3(C)[C@@]4(O)C(=O)C[C@@](C)(O[C@]24C)C=C)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J17 compound treatment 610240.0 -1.16E7 -6.5 692760.0 -1.13E7 -6.37 604320.0 -1.06269033333333E7 -6.23985047540088 -11.0293 -0.9999 1049343 HSCI1_000326 CCC(C)C1NC(=O)C(NC(=O)c2c(N)c(=O)c(C)c3oc4c(C)ccc(C(=O)NC5C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C6CCCN6C(=O)C(NC5=O)C(C)C)c4nc23)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCN7C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J18 compound treatment 1.417508E7 2000000.0 1.12 1.322248E7 1220000.0 0.69 1.220244E7 971216.6666667 0.570274010135046 1.3736 0.9578 3054969 HSCI1_000327 C[C@@]12CCC(=O)C=C2CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@@]4(O)C[C@H](O)[C@@H]31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J19 mock treatment 1.233412E7 158000.0 0.09 1.241844E7 415000.0 0.23 1.133672E7 105496.6666667 0.0619449904647747 0.2218 0.862 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J20 mock treatment 1.22182E7 42100.0 0.02 1.192608E7 -77700.0 -0.04 1.207068E7 839456.6666667 0.492907850601068 0.273 0.551 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J21 mock treatment 1.2305E7 129000.0 0.07 1.208936E7 85600.0 0.05 1.066104E7 -570183.3333333 -0.334797318839398 -0.1237 -0.3575 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J22 mock treatment 1.184736E7 -329000.0 -0.18 1.167256E7 -331000.0 -0.19 1.065464E7 -576583.3333333 -0.338555237942445 -0.4097 -0.9565 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J23 compound treatment 1.247208E7 296000.0 0.17 1.169428E7 -310000.0 -0.17 1.076008E7 -471143.3333333 -0.276643520719748 -0.1643 -0.448 3054970 HSCI1_000328 NC(=NCCSSCCN=C(N)N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 J24 mock treatment 1.168504E7 -491000.0 -0.28 1.0737E7 -1270000.0 -0.71 9839760.0 -1391463.3333333 -0.817032287737888 -1.0427 -0.9318 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K01 mock treatment 1.149324E7 -683000.0 -0.38 1.080004E7 -1200000.0 -0.68 1.040448E7 -826743.3333333 -0.48544290088279 -0.8929 -0.9732 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K02 compound treatment 9786280.0 -2390000.0 -1.34 1.063808E7 -1370000.0 -0.77 8948320.0 -2282903.3333333 -1.34046344480353 -1.9927 -0.9736 637 HSCI1_000329 C/C(=C(\C#N)/C(=O)Nc1ccc(OC(F)(F)F)cc1)/O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K03 compound treatment 1.123052E7 -946000.0 -0.53 1.138608E7 -618000.0 -0.35 1.12982E7 66976.6666666996 0.0393270148633114 -0.4847 -0.7621 391 HSCI1_000330 Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K04 compound treatment 192720.0 -1.2E7 -6.73 185440.0 -1.18E7 -6.65 174560.0 -1.10566633333333E7 -6.49219474317048 -11.4752 -0.9999 3055003 HSCI1_000331 O=C1c2ccccc2-[n+]3ccc4c5ccccc5[nH]c4c13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K05 compound treatment 362840.0 -1.18E7 -6.64 210280.0 -1.18E7 -6.64 327000.0 -1.09042233333333E7 -6.40268580753478 -11.3603 -0.9999 3055004 HSCI1_000332 Fc1ccc(cc1)C(=O)/C=C/2\C(=O)Nc3ccc(Br)cc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K06 compound treatment 394920.0 -1.18E7 -6.62 375720.0 -1.16E7 -6.55 306880.0 -1.09243433333333E7 -6.41449976571498 -11.303 -0.9999 3176336 HSCI1_000333 CC(C)(C)C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c3ccccc32 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K07 mock treatment 1.21312E7 -44900.0 -0.03 1.202504E7 21200.0 0.01 1.138024E7 149016.6666667 0.0874988403654934 0.0429 0.4668 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K08 mock treatment 1.233396E7 158000.0 0.09 1.169548E7 -308000.0 -0.17 1.111312E7 -118103.3333333 -0.0693473081979252 -0.089 -0.4304 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K09 mock treatment 1.253436E7 358000.0 0.2 1.305384E7 1050000.0 0.59 1.10498E7 -181423.3333333 -0.106527220323695 0.3959 0.6251 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K10 mock treatment 1.271232E7 536000.0 0.3 1.252096E7 517000.0 0.29 1.08578E7 -373423.3333333 -0.219264793415101 0.2154 0.4555 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K11 compound treatment 6295160.0 -5880000.0 -3.3 6414920.0 -5590000.0 -3.15 5774960.0 -5456263.3333333 -3.20378065806053 -5.5732 -0.9998 3055006 HSCI1_000334 COc1cccc(c1)c2cc(NCc3ccc4OCOc4c3)nc(N)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K12 compound treatment 1.228076E7 105000.0 0.06 1.073912E7 -1260000.0 -0.71 1.06164E7 -614823.3333333 -0.36100880458315 -0.5855 -0.7315 3176337 HSCI1_000335 COc1ccc(cc1)c2cnc3c(cnn3c2)c4ccsc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K13 compound treatment 8494040.0 -3680000.0 -2.07 8194080.0 -3810000.0 -2.14 7512640.0 -3718583.3333333 -2.18345864759452 -3.6928 -0.9997 3055009 HSCI1_000336 CC1=C(O)C(=O)[C@H]2O[C@H]2C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K14 compound treatment 1.152968E7 -646000.0 -0.36 1.441236E7 2410000.0 1.36 1.114144E7 -89783.3333333004 -0.0527185161669428 0.5427 0.3864 1709 HSCI1_000337 NCCCC(O)(P(=O)(O)O)P(=O)(O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K15 mock treatment 1.234184E7 166000.0 0.09 1.188024E7 -124000.0 -0.07 1.130148E7 70256.6666666996 0.0412529484036229 0.0374 0.3034 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K16 mock treatment 1.243648E7 260000.0 0.15 1.183756E7 -166000.0 -0.09 1.100568E7 -225543.3333333 -0.132433375140325 -0.046 -0.2108 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K17 compound treatment 1.144304E7 -733000.0 -0.41 1.21092E7 105000.0 0.06 1.096704E7 -264183.3333333 -0.15512181172497 -0.293 -0.66 3176338 HSCI1_000338 CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(=O)(O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K18 compound treatment 7570560.0 -4610000.0 -2.59 7218160.0 -4790000.0 -2.69 6936440.0 -4294783.3333333 -2.5217888018407 -4.5048 -0.9996 1932 HSCI1_000339 OP(=O)(O)Oc1cccc2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K19 compound treatment 1.13298E7 -846000.0 -0.48 1.105168E7 -952000.0 -0.54 1.068276E7 -548463.3333333 -0.322043880883433 -0.7698 -0.9801 95 HSCI1_000340 CCCCCC(O)/C=C/C=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K20 compound treatment 1.117504E7 -1000000.0 -0.56 1.092484E7 -1080000.0 -0.61 1.015136E7 -1079863.3333333 -0.634068601408293 -1.0414 -0.9988 3176339 HSCI1_000341 CC(C)[C@@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@@H](O)C[C@H](O)C3=C)\CCC[C@]12C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K21 mock treatment 1.212784E7 -48200.0 -0.03 1.146892E7 -535000.0 -0.3 1.03808E7 -850423.3333333 -0.499347201564063 -0.4778 -0.8185 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K22 mock treatment 1.179888E7 -377000.0 -0.21 1.168036E7 -323000.0 -0.18 1.084492E7 -386303.3333333 -0.226827605609983 -0.3584 -0.996 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K23 mock treatment 1.162192E7 -554000.0 -0.31 1.120824E7 -796000.0 -0.45 1.08872E7 -344023.3333333 -0.20200185253548 -0.5549 -0.9541 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 K24 mock treatment 1.034232E7 -1830000.0 -1.03 1.06904E7 -1310000.0 -0.74 1.057008E7 -661143.3333333 -0.388206744091452 -1.2456 -0.9394 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L01 mock treatment 1.210484E7 -71200.0 -0.04 1.1902E7 -102000.0 -0.06 1.107828E7 -152943.3333333 -0.0898044803151366 -0.108 -0.9494 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L02 compound treatment 1.243128E7 255000.0 0.14 1.16176E7 -386000.0 -0.22 1.11012E7 -130023.3333333 -0.07634643252735 -0.0868 -0.32 594 HSCI1_000342 Cc1nc2sccn2c(=O)c1CCN3CCC(=C(c4ccccc4)c5ccc(F)cc5)CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L03 compound treatment 363360.0 -1.18E7 -6.63 343800.0 -1.17E7 -6.56 316880.0 -1.09143433333333E7 -6.40862801711647 -11.3202 -0.9999 581 HSCI1_000343 Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L04 compound treatment 5549320.0 -6630000.0 -3.72 2181640.0 -9820000.0 -5.53 5376760.0 -5854463.3333333 -3.43759368725323 -7.3258 -0.9769 1002019 HSCI1_000344 COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L05 compound treatment 5792440.0 -6380000.0 -3.59 5801240.0 -6200000.0 -3.49 5236960.0 -5994263.3333333 -3.51968073266041 -6.118 -0.9999 3055016 HSCI1_000345 COc1cc2ncnc(N3CCN(CC3)C(=O)Nc4ccc(Oc5ccccc5)cc4)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L06 compound treatment 1.201068E7 -165000.0 -0.09 9009280.0 -2990000.0 -1.69 9735760.0 -1495463.3333333 -0.878098473162399 -1.5338 -0.806 2348 HSCI1_000346 COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)CCC5=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L07 mock treatment 1.258272E7 407000.0 0.23 1.359668E7 1590000.0 0.9 1.140436E7 173136.6666667 0.101661497985101 0.7082 0.7609 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L08 mock treatment 1.281744E7 641000.0 0.36 1.309964E7 1100000.0 0.62 1.17294E7 498176.6666667 0.292516814431094 0.733 0.9496 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L09 mock treatment 1.323324E7 1060000.0 0.59 1.299012E7 986000.0 0.56 1.107228E7 -158943.3333333 -0.0933275294742431 0.6095 0.7449 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L10 mock treatment 1.314316E7 967000.0 0.54 1.312248E7 1120000.0 0.63 1.17614E7 530176.6666667 0.311306409946328 0.8569 0.965 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L11 compound treatment 2741680.0 -9430000.0 -5.3 2358600.0 -9650000.0 -5.43 2040880.0 -9190343.3333333 -5.39633855873322 -9.3097 -0.9999 582 HSCI1_000347 CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L12 compound treatment 1.348028E7 1300000.0 0.73 1.19616E7 -42200.0 -0.02 1.1388E7 156776.6666667 0.0920553172779377 0.4624 0.6259 595 HSCI1_000348 Fc1ccc(cc1)C(=C2CCN(CCn3c(=O)c4ccccc4[nH]c3=S)CC2)c5ccc(F)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L13 compound treatment 1.015868E7 -2020000.0 -1.13 1.23664E7 363000.0 0.2 1.22518E7 1020576.6666667 0.599256961217295 -0.1904 -0.1467 3176385 HSCI1_000349 NCC1OC(OC2C(N)CC(N)C(O)C2O[C@@H]3OC[C@H](COCC4OCC(O)C(O)C4N)[C@@H]3O)C(N)C(O)C1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L14 compound treatment 1.122296E7 -953000.0 -0.54 1.059644E7 -1410000.0 -0.79 1.036324E7 -867983.3333333 -0.509657992103048 -1.0607 -0.979 3055065 HSCI1_000350 Nc1ncn([C@@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L15 mock treatment 1.298076E7 805000.0 0.45 1.22126E7 209000.0 0.12 1.14306E7 199376.6666667 0.117068966307593 0.3964 0.8233 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L16 mock treatment 1.250872E7 333000.0 0.19 1.209452E7 90700.0 0.05 1.11338E7 -97423.3333333004 -0.057204532096205 0.1043 0.5166 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L17 compound treatment 9042000.0 -3130000.0 -1.76 9113360.0 -2890000.0 -1.63 8220520.0 -3010703.3333333 -1.76780930780314 -2.9764 -0.9993 372 HSCI1_000351 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L18 compound treatment 1.299656E7 820000.0 0.46 1.203844E7 34600.0 0.02 1.11506E7 -80623.3333333004 -0.047339994450707 0.25 0.5392 1367 HSCI1_000352 Cc1cc(O)ccc1Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L19 compound treatment 491320.0 -1.17E7 -6.56 556160.0 -1.14E7 -6.44 589600.0 -1.06416233333333E7 -6.24849368933789 -11.1172 -0.9998 3055069 HSCI1_000353 CC/C(=C(\c1ccc(O)cc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L20 compound treatment 1.203424E7 -142000.0 -0.08 1.208852E7 84700.0 0.05 1.135552E7 124296.6666667 0.0729838778299749 0.0237 0.2005 2237 HSCI1_000354 FS(=O)(=O)Cc1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L21 mock treatment 1.207712E7 -99000.0 -0.06 1.19868E7 -17000.0 -0.01 9552680.0 -1678543.3333333 -0.985598446503934 -0.6066 -0.6145 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L22 mock treatment 1.193576E7 -240000.0 -0.13 1.11282E7 -876000.0 -0.49 1.069872E7 -532503.3333333 -0.31267257012021 -0.543 -0.9064 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L23 mock treatment 1.205612E7 -120000.0 -0.07 1.152644E7 -477000.0 -0.27 1.06016E7 -629623.3333333 -0.369698992508946 -0.4075 -0.882 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 L24 mock treatment 1.085436E7 -1320000.0 -0.74 1.12808E7 -723000.0 -0.41 1.148532E7 254096.6666667 0.149199174638644 -0.5774 -0.6717 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M01 mock treatment 1.240676E7 231000.0 0.13 1.048176E7 -1520000.0 -0.86 1.080472E7 -426503.3333333 -0.250432034975996 -0.5644 -0.6258 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M02 compound treatment 1.01198E7 -2060000.0 -1.15 9891160.0 -2110000.0 -1.19 9198480.0 -2032743.3333333 -1.19357578186318 -2.0425 -0.9999 1900 HSCI1_000355 COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M03 compound treatment 7489920.0 -4690000.0 -2.63 6980120.0 -5020000.0 -2.83 6971400.0 -4259823.3333333 -2.50126116874031 -4.5964 -0.9987 3055072 HSCI1_000356 Cn1cc(/C=C/2\C(=O)Nc3ccc(cc23)S(=O)(=O)N)c4ccccc14 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M04 compound treatment 3683960.0 -8490000.0 -4.77 3794400.0 -8210000.0 -4.62 3806080.0 -7425143.3333333 -4.35985749612411 -7.9391 -0.9993 292 HSCI1_000357 O=C1NCc2c1c3c4ccccc4[nH]c3c5[nH]c6ccccc6c25 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M05 compound treatment 9047880.0 -3130000.0 -1.76 8680280.0 -3320000.0 -1.87 8470440.0 -2760783.3333333 -1.62106256682916 -3.0305 -0.9983 907290 HSCI1_000358 CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](O)[C@@]3(C)O[C@](C)(CC(=O)[C@@]32O)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M06 compound treatment 1.445896E7 2280000.0 1.28 1.354584E7 1540000.0 0.87 1.301044E7 1779216.6666667 1.04471129689471 1.8446 0.9875 3055076 HSCI1_000359 NS(=O)(=O)c1ccc(N/C=C/2\C(=O)Nc3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M07 compound treatment 1.192332E7 -253000.0 -0.14 1.119568E7 -808000.0 -0.45 1.090852E7 -322703.3333333 -0.189483284523455 -0.454 -0.8853 3055122 HSCI1_000360 OC(=O)c1ccc2c3nc4ccccc4n3c(=O)c5cccc1c52 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M08 compound treatment 2843960.0 -9330000.0 -5.24 2737760.0 -9270000.0 -5.22 2495040.0 -8736183.3333333 -5.12966722438326 -8.9993 -1.0 3176387 HSCI1_000361 Nc1cccc(c1)c2cc3c(Oc4cccc(O)c4)ncnc3[nH]2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M09 mock treatment 1.272836E7 552000.0 0.31 1.220628E7 202000.0 0.11 1.145484E7 223616.6666667 0.131302084910383 0.3207 0.9019 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M10 mock treatment 1.272496E7 549000.0 0.31 1.242312E7 419000.0 0.24 1.152544E7 294216.6666667 0.172756630015869 0.414 0.9742 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M11 mock treatment 1.356152E7 1390000.0 0.78 1.309208E7 1090000.0 0.61 1.200656E7 775336.6666667 0.455258198587417 1.0658 0.9778 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M12 mock treatment 1.280144E7 625000.0 0.35 1.247256E7 469000.0 0.26 1.173264E7 501416.6666667 0.294419260977012 0.5251 0.9929 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M13 mock treatment 1.417328E7 2000000.0 1.12 1.337584E7 1370000.0 0.77 1.289524E7 1664016.6666667 0.977068753039869 1.6577 0.989 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M14 mock treatment 1.333564E7 1160000.0 0.65 1.265504E7 651000.0 0.37 1.1627E7 395776.6666667 0.232390108782344 0.7219 0.9223 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M15 compound treatment 1.101724E7 -1160000.0 -0.65 1.097976E7 -1020000.0 -0.58 1.022188E7 -1009343.3333333 -0.592661030291596 -1.0508 -0.9986 2796 HSCI1_000362 CCCCCCCC/C=C\CCCCCCCC(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M16 compound treatment 503560.0 -1.17E7 -6.56 561560.0 -1.14E7 -6.44 474080.0 -1.07571433333333E7 -6.31632412914789 -11.1507 -0.9999 3176388 HSCI1_000363 COC(=O)CC(O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@@H]2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M17 compound treatment 9468080.0 -2710000.0 -1.52 1.1911E7 -92800.0 -0.05 1.15172E7 285976.6666667 0.167918309170696 -0.8114 -0.5299 1000076 HSCI1_000364 CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OCC[N+](C)(C)C)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M18 compound treatment 1.067592E7 -1500000.0 -0.84 9484920.0 -2520000.0 -1.42 9891320.0 -1339903.3333333 -0.786757551963966 -1.7593 -0.9628 2058 HSCI1_000365 OC(=O)C1C(C2CCC1O2)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M19 compound treatment 1.18432E7 -333000.0 -0.19 1.12646E7 -739000.0 -0.42 1.1012E7 -219223.3333333 -0.128722430026066 -0.4225 -0.8914 1000072 HSCI1_000366 CC(C)OP(=O)(F)OC(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M20 compound treatment 336680.0 -1.18E7 -6.65 370960.0 -1.16E7 -6.55 322040.0 -1.09091833333333E7 -6.40559819483964 -11.3183 -0.9999 3176389 HSCI1_000367 CC(=O)O[C@@H]1CC2[C@@]3(C)CCCC(C)(C)C3CC[C@@]2(C)C4CC=C(C=O)[C@H](C=O)[C@@]14C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M21 compound treatment 1.074668E7 -1430000.0 -0.8 1.118792E7 -816000.0 -0.46 1.0001E7 -1230223.3333333 -0.722356213335501 -1.1457 -0.9763 3176390 HSCI1_000368 CCCC(=O)OC1C(OC2COP(O)(O)OC12)n3cnc4c(=O)[nH]c(NOC(=C)CC)nc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M22 compound treatment 9553000.0 -2620000.0 -1.47 9137320.0 -2870000.0 -1.61 9419560.0 -1811663.3333333 -1.06376316384731 -2.3964 -0.9861 3055129 HSCI1_000369 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@@]21C)c5ccc(cc5)N(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M23 mock treatment 1.154824E7 -628000.0 -0.35 1.134644E7 -657000.0 -0.37 1.059388E7 -637343.3333333 -0.374231982426996 -0.6333 -0.9997 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 M24 mock treatment 1.152308E7 -653000.0 -0.37 1.0519E7 -1480000.0 -0.84 9945000.0 -1286223.3333333 -0.755238005487161 -1.1303 -0.9541 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N01 mock treatment 1.275164E7 576000.0 0.32 1.24198E7 416000.0 0.23 1.244E7 1208776.6666667 0.709763269841267 0.7316 0.8985 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N02 compound treatment 1477920.0 -1.07E7 -6.01 1345480.0 -1.07E7 -6.0 1530920.0 -9700303.3333333 -5.69577425026288 -10.2216 -0.9997 600 HSCI1_000370 COC(=O)/C=C/c1cc(O)ccc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N03 compound treatment 4735000.0 -7440000.0 -4.18 5161120.0 -6840000.0 -3.85 5295280.0 -5935943.3333333 -3.48543669483389 -6.6492 -0.9973 630 HSCI1_000371 COc1ccc(cc1)S(=O)(=O)N(CCO)c2ccccc2CN(C)C/C=C/c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N04 compound treatment 1.071856E7 -1460000.0 -0.82 1.04684E7 -1540000.0 -0.86 9737320.0 -1493903.3333333 -0.877182480381032 -1.4781 -0.9996 2283 HSCI1_000372 CCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N05 compound treatment 1.1975E7 -201000.0 -0.11 1.201036E7 6570.0 0.0 1.380532E7 2574096.6666667 1.51144484949313 0.8096 0.5341 629 HSCI1_000373 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2CN(C)C/C=C/c3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N06 compound treatment 1.334924E7 1170000.0 0.66 1.429252E7 2290000.0 1.29 1.437724E7 3146016.6666667 1.84726189533916 2.1908 0.9336 1884 HSCI1_000374 Cc1ccnc(N)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N07 compound treatment 9729440.0 -2450000.0 -1.37 9418480.0 -2590000.0 -1.46 1.026932E7 -961903.3333333 -0.564805454940261 -1.9597 -0.9423 1918023 HSCI1_000375 CC[n+]1c(/C=C/N(C)c2ccccc2)n(c3ccccc3)c4ccc(cc14)c5nc6ccccc6s5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N08 compound treatment 1.181788E7 -358000.0 -0.2 1.185352E7 -150000.0 -0.08 1.10508E7 -180423.3333333 -0.105940045463844 -0.2262 -0.9322 2344 HSCI1_000376 FC(F)(F)C(=O)CC(=O)c1cccs1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N09 mock treatment 1.352284E7 1350000.0 0.76 1.289796E7 894000.0 0.5 1.181828E7 587056.6666667 0.344704915974657 0.9264 0.9532 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N10 mock treatment 1.627052E7 4090000.0 2.3 1.353816E7 1530000.0 0.86 1.220128E7 970056.6666667 0.569592887297618 2.1553 0.8547 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N11 mock treatment 1.332032E7 1140000.0 0.64 1.33454E7 1340000.0 0.76 1.250388E7 1272656.6666667 0.747271999888553 1.2385 0.9974 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N12 mock treatment 1.651052E7 4330000.0 2.43 1.435968E7 2360000.0 1.33 1.66206E7 5389376.6666667 3.16450648893466 3.9983 0.9504 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N13 mock treatment 1.337432E7 1200000.0 0.67 1.351576E7 1510000.0 0.85 1.19508E7 719576.6666667 0.422517328402122 1.1239 0.9652 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N14 mock treatment 1.309748E7 921000.0 0.52 1.333576E7 1330000.0 0.75 1.317572E7 1944496.6666667 1.1417595577309 1.3909 0.9522 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N15 compound treatment 4286600.0 -7890000.0 -4.43 2868040.0 -9140000.0 -5.14 2891400.0 -8339823.3333333 -4.89693459693269 -8.3548 -0.9981 1000048 HSCI1_000377 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N16 compound treatment 1.313136E7 955000.0 0.54 1.294132E7 938000.0 0.53 1.210164E7 870416.6666667 0.511086784262057 0.9096 0.9998 2187 HSCI1_000378 O=C(NC1CCCCC1)NC2CCCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N17 compound treatment 1.323388E7 1060000.0 0.59 1.310092E7 1100000.0 0.62 1.200356E7 772336.6666667 0.453496674007864 0.9614 0.9916 2083 HSCI1_000379 CC(CCC(=O)NCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N18 compound treatment 1.407312E7 1900000.0 1.07 1.213012E7 126000.0 0.07 1.238132E7 1150096.6666667 0.675307849065206 1.0461 0.828 1934 HSCI1_000380 NNC(=N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N19 compound treatment 1.192068E7 -255000.0 -0.14 1.223004E7 226000.0 0.13 1.091164E7 -319583.3333333 -0.187651298960719 -0.1176 -0.4384 30 HSCI1_000381 COC(=O)C1=C(C)NC(=C(C1c2ccccc2C(F)(F)F)[N+](=O)[O-])C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N20 compound treatment 319640.0 -1.19E7 -6.66 339520.0 -1.17E7 -6.57 286520.0 -1.09447033333333E7 -6.42645464586155 -11.346 -0.9999 420 HSCI1_000382 CCN1C(=O)C=CC1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N21 compound treatment 1.318052E7 1000000.0 0.56 1.27318E7 728000.0 0.41 1.274004E7 1508816.6666667 0.885939214790982 1.0738 0.9524 3054850 HSCI1_000383 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N22 compound treatment 6318280.0 -5860000.0 -3.29 6357080.0 -5650000.0 -3.18 5992440.0 -5238783.3333333 -3.07608186954012 -5.5107 -0.9996 2003 HSCI1_000384 CNC1CCc2cc(OC)c(OC)c(OC)c2-c3ccc(OC)c(=O)cc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N23 mock treatment 1.21466E7 -29500.0 -0.02 1.215336E7 150000.0 0.08 1.48634E7 3632176.6666667 2.13272282520436 1.2704 0.5952 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 N24 mock treatment 1.126448E7 -912000.0 -0.51 1.059048E7 -1410000.0 -0.8 1.194728E7 716056.6666667 0.420450472895446 -0.5122 -0.4947 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O01 mock treatment 1.152656E7 -650000.0 -0.36 1.096428E7 -1040000.0 -0.59 1.036904E7 -862183.3333333 -0.506252377915912 -0.8408 -0.9828 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O02 mock treatment 1.340508E7 1230000.0 0.69 1.306024E7 1060000.0 0.59 1.558104E7 4349816.6666667 2.55410299162788 2.2165 0.8174 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O03 compound treatment 7033760.0 -5140000.0 -2.89 7269960.0 -4730000.0 -2.66 7043040.0 -4188183.3333333 -2.45919596178058 -4.6259 -0.9979 3054852 HSCI1_000385 O=C/1Nc2ccc(cc2\C1=C\c3ccc[nH]3)c4cccnc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O04 compound treatment 2098760.0 -1.01E7 -5.66 2017640.0 -9990000.0 -5.62 2007480.0 -9223743.3333333 -5.41595019905225 -9.6403 -0.9998 3176393 HSCI1_000386 Cn1nc(N)c2cn(C3OC(CO)C(O)C3O)c4ncnc1c24 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O05 compound treatment 3187560.0 -8990000.0 -5.05 2951880.0 -9050000.0 -5.1 3012120.0 -8219103.3333333 -4.82605084785147 -8.643 -0.9997 3176394 HSCI1_000387 C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5[nH]cnc25 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O06 compound treatment 9761200.0 -2410000.0 -1.36 9715160.0 -2290000.0 -1.29 8926560.0 -2304663.3333333 -1.35324036975389 -2.3082 -0.9997 575 HSCI1_000388 O=C1NC(=O)C(=C1c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O07 compound treatment 1.064676E7 -1530000.0 -0.86 8622600.0 -3380000.0 -1.9 8741280.0 -2489943.3333333 -1.46203212778709 -2.4389 -0.9568 3176395 HSCI1_000389 CCCCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@@H](N2C1=O)c5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O08 compound treatment 1.260148E7 425000.0 0.24 1.165736E7 -346000.0 -0.2 1.101172E7 -219503.3333333 -0.128886838986824 -0.049 -0.1467 2116778 HSCI1_000390 CCOC(=O)c1cnc2oc3ccc(O)cc3c2c1c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O09 compound treatment 5749160.0 -6430000.0 -3.61 5463840.0 -6540000.0 -3.68 4779360.0 -6451863.3333333 -3.78837194852826 -6.3968 -0.9998 3176396 HSCI1_000391 CC(C)[C@H](CO)Nc1nc(Nc2cc(N)cc(Cl)c2)c3ncn(C(C)C)c3n1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O10 compound treatment 8887160.0 -3290000.0 -1.85 1.109776E7 -906000.0 -0.51 8483440.0 -2747783.3333333 -1.6134292936511 -2.2925 -0.9151 676 HSCI1_000392 COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O11 mock treatment 1.335176E7 1180000.0 0.66 1.291952E7 916000.0 0.52 1.17924E7 561176.6666667 0.329508830601712 0.8691 0.9655 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O12 mock treatment 1.48736E7 2700000.0 1.52 1.334704E7 1340000.0 0.76 1.228564E7 1054416.6666667 0.619126958474655 1.6688 0.9256 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O13 mock treatment 1.30984E7 922000.0 0.52 1.279056E7 787000.0 0.44 1.124756E7 16336.6666666996 0.00959247996045302 0.5603 0.8221 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O14 mock treatment 1.585172E7 3680000.0 2.06 1.322096E7 1220000.0 0.69 1.233708E7 1105856.6666667 0.649331233265394 1.9624 0.8645 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O15 compound treatment 1.197508E7 -201000.0 -0.11 1.233112E7 327000.0 0.18 1.171356E7 482336.6666667 0.283215964651053 0.2047 0.5747 1398 HSCI1_000393 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OC(=O)C)c(C)c(C)c2O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O16 compound treatment 1.429504E7 2120000.0 1.19 1.230176E7 298000.0 0.17 1.154484E7 313616.6666667 0.18414782229698 0.8903 0.7322 2060355 HSCI1_000394 CC1=C(C=C)/C(=C/c2[nH]c(Cc3[nH]c(\C=C\4/NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)/NC1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O17 compound treatment 1.219912E7 23000.0 0.01 1.23442E7 340000.0 0.19 1.173616E7 504936.6666667 0.296486116483687 0.2893 0.8189 1929 HSCI1_000395 Nc1cccc2c(=O)[nH]ccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O18 compound treatment 1.238168E7 206000.0 0.12 1.195332E7 -50500.0 -0.03 1.134276E7 111536.6666667 0.0654915266182752 0.0881 0.6488 2286 HSCI1_000396 CCSC(=N)N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O19 compound treatment 1.251048E7 334000.0 0.19 1.161236E7 -391000.0 -0.22 1.190368E7 672456.6666667 0.394849649005939 0.2092 0.4273 23 HSCI1_000397 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O20 compound treatment 7661520.0 -4510000.0 -2.54 7330480.0 -4670000.0 -2.63 7068960.0 -4162263.3333333 -2.44397638941324 -4.3939 -0.9995 3054913 HSCI1_000398 Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc2ccccc2)C(=O)CCl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O21 compound treatment 9145760.0 -3030000.0 -1.7 9632720.0 -2370000.0 -1.33 9500640.0 -1730583.3333333 -1.01615502621058 -2.34 -0.9792 3176397 HSCI1_000399 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(=C/C=C/3\C[C@@H](O)C[C@H](O)C3=C)/CCC[C@@]12C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O22 compound treatment 1.141364E7 -762000.0 -0.43 1.101604E7 -988000.0 -0.56 1.05578E7 -673423.3333333 -0.395417251370423 -0.7966 -0.9888 988 HSCI1_000400 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O23 mock treatment 1.199704E7 -179000.0 -0.1 1.113248E7 -871000.0 -0.49 1.067712E7 -554103.3333333 -0.325355547092993 -0.5291 -0.8861 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 O24 mock treatment 1.142924E7 -747000.0 -0.42 1.028776E7 -1720000.0 -0.97 9766280.0 -1464943.3333333 -0.860177896439744 -1.2965 -0.9535 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P01 mock treatment 9702360.0 -2470000.0 -1.39 9844960.0 -2160000.0 -1.22 9471080.0 -1760143.3333333 -1.03351191506778 -2.1005 -0.9929 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P02 mock treatment 1.130176E7 -874000.0 -0.49 1.094416E7 -1060000.0 -0.6 1.101624E7 -214983.3333333 -0.126232808620297 -0.7008 -0.8951 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P03 mock treatment 1.217132E7 -4750.0 0.0 1.142592E7 -578000.0 -0.33 1.111364E7 -117583.3333333 -0.0690419772708027 -0.2292 -0.6893 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P04 mock treatment 1.190468E7 -271000.0 -0.15 1.173024E7 -274000.0 -0.15 1.084524E7 -385983.3333333 -0.226639709654831 -0.3078 -0.9815 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P05 mock treatment 1.161112E7 -565000.0 -0.32 1.216316E7 159000.0 0.09 1.199592E7 764696.6666667 0.449010658078602 0.1278 0.2294 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P06 mock treatment 1.204044E7 -136000.0 -0.08 1.18788E7 -125000.0 -0.07 1.078756E7 -443663.3333333 -0.260507955571041 -0.235 -0.8382 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P07 mock treatment 1.206324E7 -113000.0 -0.06 1.208132E7 77500.0 0.04 1.116492E7 -66303.3333333004 -0.0389316504576397 -0.0339 -0.3928 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P08 mock treatment 1.185008E7 -326000.0 -0.18 1.272432E7 721000.0 0.41 1.240992E7 1178696.6666667 0.692101050056946 0.528 0.6417 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P09 mock treatment 1.185252E7 -324000.0 -0.18 1.23536E7 350000.0 0.2 1.175696E7 525736.6666667 0.30869935356859 0.187 0.4574 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P10 mock treatment 1.240812E7 232000.0 0.13 1.221684E7 213000.0 0.12 1.181404E7 582816.6666667 0.342215294568889 0.3421 0.8877 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P11 mock treatment 1.299564E7 820000.0 0.46 1.281024E7 806000.0 0.45 1.163444E7 403216.6666667 0.236758689739636 0.6646 0.9652 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P12 mock treatment 1.216748E7 -8590.0 0.0 1.212764E7 124000.0 0.07 1.152556E7 294336.6666667 0.172827090999051 0.1372 0.7362 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P13 mock treatment 1.117188E7 -1000000.0 -0.56 1.1777E7 -227000.0 -0.13 1.108336E7 -147863.3333333 -0.0868216320270932 -0.4495 -0.7686 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P14 mock treatment 1.237324E7 197000.0 0.11 1.239912E7 395000.0 0.22 1.173676E7 505536.6666667 0.296838421399598 0.3638 0.9396 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P15 mock treatment 1.230468E7 129000.0 0.07 1.21238E7 120000.0 0.07 1.1524E7 292776.6666667 0.171911098217684 0.18 0.9074 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P16 mock treatment 1.149364E7 -682000.0 -0.38 1.167876E7 -325000.0 -0.18 1.102428E7 -206943.3333333 -0.121511922747095 -0.3971 -0.8989 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P17 mock treatment 1.169872E7 -477000.0 -0.27 9354400.0 -2650000.0 -1.49 1.08944E7 -336823.3333333 -0.197774193544552 -1.13 -0.7395 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P18 mock treatment 1.218244E7 6370.0 0.0 1.244856E7 445000.0 0.25 1.143568E7 204456.6666667 0.120051814595637 0.2159 0.7776 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P19 mock treatment 1.148752E7 -689000.0 -0.39 1.131784E7 -686000.0 -0.39 9715720.0 -1515503.3333333 -0.889865457353815 -0.96 -0.9193 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P20 mock treatment 1.128232E7 -894000.0 -0.5 1.118408E7 -820000.0 -0.46 1.037172E7 -859503.3333333 -0.504678749291511 -0.8476 -0.9992 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P21 mock treatment 1.098132E7 -1190000.0 -0.67 1.14948E7 -509000.0 -0.29 1.103248E7 -198743.3333333 -0.116697088896316 -0.6202 -0.8394 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P22 mock treatment 1.156428E7 -612000.0 -0.34 1.094972E7 -1050000.0 -0.59 1.06248E7 -606423.3333333 -0.356076535760401 -0.7465 -0.9663 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P23 mock treatment 9447080.0 -2730000.0 -1.53 1.008464E7 -1920000.0 -1.08 9833920.0 -1397303.3333333 -0.820461388919418 -1.9824 -0.9685 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2105 P24 mock treatment 7762240.0 -4410000.0 -2.48 8280480.0 -3720000.0 -2.1 7928840.0 -3302383.3333333 -1.9390764709245 -3.7609 -0.9946 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A01 compound treatment 8980160.0 -3130000.0 -1.76 9504760.0 -3360000.0 -1.89 -2.5796 -0.9993 3220649 PK04_107001 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A02 compound treatment 1.054012E7 -1570000.0 -0.88 1.01186E7 -2740000.0 -1.54 -1.7157 -0.9646 3188507 PK04_107002 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(o3)c4ccc(Cl)c(Cl)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A03 compound treatment 1.057572E7 -1530000.0 -0.86 1.042976E7 -2430000.0 -1.37 -1.5777 -0.9751 3220651 PK04_107003 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4cncn4C)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A04 compound treatment 1.091232E7 -1200000.0 -0.67 1.109012E7 -1770000.0 -1.0 -1.1812 -0.9816 3070126 PK04_107004 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A05 compound treatment 1.008868E7 -2020000.0 -1.14 1.115812E7 -1700000.0 -0.96 -1.4813 -0.9965 3220653 PK04_107005 CCCCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A06 compound treatment 1.123072E7 -879000.0 -0.49 1.141536E7 -1450000.0 -0.81 -0.9253 -0.9712 3070127 PK04_107006 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A07 compound treatment 1.15058E7 -604000.0 -0.34 1.142892E7 -1430000.0 -0.81 -0.8106 -0.9258 3220655 PK04_107007 CCOC(=O)c1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A08 compound treatment 1.099828E7 -1110000.0 -0.62 1.146172E7 -1400000.0 -0.79 -0.9991 -0.9933 3070128 PK04_107008 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3CO[Si](C(C)C)(C(C)C)c31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A09 compound treatment 1.1232E7 -878000.0 -0.49 1.122148E7 -1640000.0 -0.92 -1.0019 -0.9567 3220657 PK04_107009 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)c3ccccn3)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A10 compound treatment 1.167252E7 -437000.0 -0.25 1.208864E7 -774000.0 -0.44 -0.4818 -0.9632 3070129 PK04_107010 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C3CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A11 compound treatment 1.1337E7 -773000.0 -0.43 1.184196E7 -1020000.0 -0.57 -0.7133 -0.9904 3220659 PK04_107011 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCCC3)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A12 compound treatment 1.167084E7 -439000.0 -0.25 1.176208E7 -1100000.0 -0.62 -0.6125 -0.9184 3188513 PK04_107012 CCCCCCc1nc(CCCc2cc3CO[Si](C(C)C)(C(C)C)c3c(CCCCCC)n2)cc4CO[Si](C(C)C)(C(C)C)c41 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A13 mock treatment 1.120592E7 -904000.0 -0.51 1.202896E7 -834000.0 -0.47 -0.6909 -0.9992 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A14 mock treatment 1.133552E7 -774000.0 -0.43 1.163836E7 -1220000.0 -0.69 -0.7949 -0.9753 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A15 compound treatment 1.06994E7 -1410000.0 -0.79 1.184124E7 -1020000.0 -0.58 -0.9668 -0.9876 3220661 PK04_107013 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A16 compound treatment 1.084284E7 -1270000.0 -0.71 1.152816E7 -1330000.0 -0.75 -1.0344 -0.9996 3188514 PK04_107014 CCCCCCc1nc(c2ccc(o2)c3ccc(Cl)c(Cl)c3)c(C)c4CO[Si](C(C)C)(C(C)C)c41 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A17 compound treatment 1.083928E7 -1270000.0 -0.71 1.158708E7 -1280000.0 -0.72 -1.0124 -1.0 3220663 PK04_107015 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)c3ccccc3C)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A18 compound treatment 1.086828E7 -1240000.0 -0.7 1.13354E7 -1530000.0 -0.86 -1.1011 -0.9946 3070178 PK04_107016 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A19 compound treatment 9892360.0 -2220000.0 -1.25 1.138184E7 -1480000.0 -0.83 -1.4702 -0.9809 3220665 PK04_107017 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(Cc3ccccc3)nn2)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A20 compound treatment 1.076496E7 -1340000.0 -0.76 1.105252E7 -1810000.0 -1.02 -1.2547 -0.9891 3070179 PK04_107018 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A21 compound treatment 1.005388E7 -2060000.0 -1.15 1.07994E7 -2060000.0 -1.16 -1.6379 -1.0 3220667 PK04_107019 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)C3(O)CCCCC3)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A22 compound treatment 9621320.0 -2490000.0 -1.4 1.054752E7 -2320000.0 -1.3 -1.9099 -0.9994 3070180 PK04_107020 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A23 compound treatment 9512160.0 -2600000.0 -1.46 1.019344E7 -2670000.0 -1.5 -2.0942 -0.9999 3220669 PK04_107021 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)c3cncn3C)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 A24 compound treatment 6697840.0 -5410000.0 -3.04 8913840.0 -3950000.0 -2.22 -3.7213 -0.9882 3070181 PK04_107022 CCCCCCc1nc(C2CC2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B01 compound treatment 1.053244E7 -1580000.0 -0.89 1.113276E7 -1730000.0 -0.97 -1.3151 -0.9989 3188518 PK04_107023 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B02 compound treatment 1.173324E7 -377000.0 -0.21 1.20444E7 -818000.0 -0.46 -0.4753 -0.9376 3188519 PK04_107024 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B03 compound treatment 1.188228E7 -227000.0 -0.13 1.25796E7 -283000.0 -0.16 -0.2031 -0.994 3070182 PK04_107025 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B04 compound treatment 1.228768E7 178000.0 0.1 1.2309E7 -554000.0 -0.31 -0.1498 -0.4575 3188520 PK04_107026 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B05 compound treatment 1.201384E7 -95900.0 -0.05 1.229628E7 -567000.0 -0.32 -0.2636 -0.815 3188521 PK04_107027 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B06 compound treatment 1.1866E7 -244000.0 -0.14 1.265804E7 -205000.0 -0.12 -0.1783 -0.9963 3070183 PK04_107028 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B07 compound treatment 1.222332E7 114000.0 0.06 1.258216E7 -281000.0 -0.16 -0.0666 -0.391 3188640 PK04_107029 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B08 compound treatment 1.230988E7 200000.0 0.11 1.27114E7 -151000.0 -0.09 0.0192 0.1361 3188641 PK04_107030 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B09 compound treatment 1.220788E7 98100.0 0.06 1.315992E7 297000.0 0.17 0.1572 0.8929 3070184 PK04_107031 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B10 compound treatment 1.24538E7 344000.0 0.19 1.353544E7 673000.0 0.38 0.4044 0.9513 3188642 PK04_107032 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B11 compound treatment 1.216284E7 53100.0 0.03 1.255208E7 -311000.0 -0.17 -0.1026 -0.5782 3070185 PK04_107033 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B12 compound treatment 1.263076E7 521000.0 0.29 1.354112E7 678000.0 0.38 0.4769 0.9914 3188643 PK04_107034 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B13 mock treatment 1.2469E7 359000.0 0.2 1.282816E7 -34700.0 -0.02 0.1289 0.6357 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B14 mock treatment 1.288408E7 774000.0 0.43 1.318888E7 326000.0 0.18 0.4373 0.9264 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B15 compound treatment 1.261052E7 501000.0 0.28 1.190344E7 -959000.0 -0.54 -0.183 -0.3005 3188644 PK04_107035 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B16 compound treatment 1.281176E7 702000.0 0.39 1.19838E7 -879000.0 -0.49 -0.0711 -0.1123 3070186 PK04_107036 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B17 compound treatment 1.212384E7 14100.0 0.01 1.276692E7 -95900.0 -0.05 -0.0326 -0.5971 3188645 PK04_107037 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B18 compound treatment 1.249228E7 383000.0 0.21 1.149892E7 -1360000.0 -0.77 -0.391 -0.4904 3188646 PK04_107038 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B19 compound treatment 1.21902E7 80400.0 0.05 1.295768E7 94800.0 0.05 0.0697 0.9966 3070187 PK04_107039 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B20 compound treatment 1.17496E7 -360000.0 -0.2 1.236992E7 -493000.0 -0.28 -0.3392 -0.9879 3188647 PK04_107040 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B21 compound treatment 1.154568E7 -564000.0 -0.32 1.18808E7 -982000.0 -0.55 -0.6149 -0.9651 3188648 PK04_107041 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B22 compound treatment 1.137864E7 -731000.0 -0.41 1.21312E7 -732000.0 -0.41 -0.5816 -1.0 3070188 PK04_107042 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B23 compound treatment 1.070856E7 -1400000.0 -0.79 1.136296E7 -1500000.0 -0.84 -1.1535 -0.9994 3188649 PK04_107043 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 B24 compound treatment 9429880.0 -2680000.0 -1.51 1.234984E7 -513000.0 -0.29 -1.2686 -0.8277 3188650 PK04_107044 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C01 compound treatment 1.112392E7 -986000.0 -0.55 1.121356E7 -1650000.0 -0.93 -1.048 -0.9695 3414054 PK04_107045 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C02 compound treatment 1.17654E7 -344000.0 -0.19 1.203368E7 -829000.0 -0.47 -0.4668 -0.9239 3188651 PK04_107046 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C03 compound treatment 1.192004E7 -190000.0 -0.11 1.220296E7 -660000.0 -0.37 -0.338 -0.8747 3414055 PK04_107047 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(Cc4ccccc4)nn3)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C04 compound treatment 1.201476E7 -95000.0 -0.05 1.20568E7 -806000.0 -0.45 -0.3586 -0.7849 3070235 PK04_107048 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4cc(C)c(OC)c(C)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C05 compound treatment 1.22114E7 102000.0 0.06 1.305316E7 190000.0 0.11 0.1161 0.9566 3414056 PK04_107049 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C06 compound treatment 1.251876E7 409000.0 0.23 1.2937E7 74100.0 0.04 0.192 0.8221 3070236 PK04_107050 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(OC)nc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C07 compound treatment 1.33708E7 1260000.0 0.71 1.26752E7 -188000.0 -0.11 0.4262 0.5951 3414057 PK04_107051 CCCCc1cn(C[C@@H]2CCCN2C(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C08 compound treatment 1.270912E7 599000.0 0.34 1.29068E7 43900.0 0.02 0.2555 0.757 3188655 PK04_107052 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3[C@@H](O[Si](C(C)C)(C(C)C)c31)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C09 compound treatment 1.222136E7 112000.0 0.06 1.324764E7 385000.0 0.22 0.1975 0.8758 3220705 PK04_107053 CCc1oc(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCCC3)c(C(=O)OC)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C10 compound treatment 1.226668E7 157000.0 0.09 1.329296E7 430000.0 0.24 0.2335 0.9063 3188656 PK04_107054 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C11 mock treatment 1.235604E7 246000.0 0.14 1.351344E7 651000.0 0.37 0.3568 0.9114 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C12 mock treatment 1.34448E7 1340000.0 0.75 1.363844E7 776000.0 0.44 0.839 0.9669 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C13 compound treatment 1.264184E7 532000.0 0.3 1.423068E7 1370000.0 0.77 0.7558 0.9151 3220708 PK04_107055 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C14 compound treatment 1.287068E7 761000.0 0.43 1.34908E7 628000.0 0.35 0.5522 0.9955 3188772 PK04_107056 CCCCCCc1nc(CCCc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCCCCC)n2)c4ccccc4)cc5[C@@H](O[Si](C(C)C)(C(C)C)c51)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C15 mock treatment 1.196968E7 -140000.0 -0.08 1.32146E7 352000.0 0.2 0.0844 0.396 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C16 mock treatment 1.192796E7 -182000.0 -0.1 1.268912E7 -174000.0 -0.1 -0.1414 -0.9998 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C17 compound treatment 1.24318E7 322000.0 0.18 1.312412E7 261000.0 0.15 0.2319 0.9947 3220711 PK04_107057 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C18 compound treatment 1.200716E7 -103000.0 -0.06 1.352468E7 662000.0 0.37 0.2227 0.5907 3070242 PK04_107058 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C19 compound treatment 1.180388E7 -306000.0 -0.17 1.319252E7 330000.0 0.19 0.0097 0.0385 3220713 PK04_107059 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4N)oc(C(=O)C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C20 compound treatment 1.18312E7 -279000.0 -0.16 1.294092E7 78100.0 0.04 -0.0796 -0.4896 3070245 PK04_107060 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C21 compound treatment 1.162376E7 -486000.0 -0.27 1.235768E7 -505000.0 -0.28 -0.3941 -0.9998 3220715 PK04_107061 COC(=O)c1cn(C[C@@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C22 compound treatment 1.142152E7 -688000.0 -0.39 1.180032E7 -1060000.0 -0.6 -0.6963 -0.9777 3070527 PK04_107062 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C23 compound treatment 1.135184E7 -758000.0 -0.43 1.182708E7 -1040000.0 -0.58 -0.7133 -0.9881 3220717 PK04_107063 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 C24 compound treatment 1.020696E7 -1900000.0 -1.07 1.011324E7 -2750000.0 -1.55 -1.8502 -0.9837 3070530 PK04_107064 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)C4CC4)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D01 compound treatment 1.188252E7 -227000.0 -0.13 1.178428E7 -1080000.0 -0.61 -0.5196 -0.8375 3188777 PK04_107065 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D02 compound treatment 1.202596E7 -83800.0 -0.05 1.219716E7 -666000.0 -0.37 -0.2983 -0.7897 3188778 PK04_107066 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D03 compound treatment 1.320368E7 1090000.0 0.61 1.273428E7 -129000.0 -0.07 0.3833 0.6195 3070575 PK04_107067 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D04 compound treatment 1.201408E7 -95700.0 -0.05 1.267316E7 -190000.0 -0.11 -0.1135 -0.9495 3188779 PK04_107068 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D05 compound treatment 1.22448E7 135000.0 0.08 1.317324E7 310000.0 0.17 0.1772 0.9302 3188780 PK04_107069 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D06 compound treatment 1.245056E7 341000.0 0.19 1.294264E7 79800.0 0.04 0.1671 0.8499 3070579 PK04_107070 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D07 compound treatment 1.281852E7 709000.0 0.4 1.312316E7 260000.0 0.15 0.3851 0.9078 3188781 PK04_107071 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D08 compound treatment 1.249596E7 386000.0 0.22 1.336692E7 504000.0 0.28 0.354 0.9912 3188782 PK04_107072 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D09 compound treatment 1.253624E7 426000.0 0.24 1.289224E7 29400.0 0.02 0.1811 0.7541 3188783 PK04_107073 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D10 compound treatment 1.269148E7 582000.0 0.33 1.263292E7 -230000.0 -0.13 0.1395 0.397 3070632 PK04_107074 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D11 mock treatment 1.266816E7 558000.0 0.31 1.392024E7 1060000.0 0.6 0.6427 0.9552 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D12 mock treatment 1.276172E7 652000.0 0.37 1.421884E7 1360000.0 0.76 0.7987 0.9434 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D13 compound treatment 1.360616E7 1500000.0 0.84 1.467396E7 1810000.0 1.02 1.3152 0.9954 3188784 PK04_107075 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D14 compound treatment 1.29826E7 873000.0 0.49 1.324012E7 377000.0 0.21 0.4968 0.9299 3188785 PK04_107076 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D15 mock treatment 1.229816E7 188000.0 0.11 1.349096E7 628000.0 0.35 0.3248 0.8802 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D16 mock treatment 1.242692E7 317000.0 0.18 1.310976E7 247000.0 0.14 0.2242 0.9925 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D17 compound treatment 1.269444E7 585000.0 0.33 1.277784E7 -85000.0 -0.05 0.1984 0.5978 3070637 PK04_107077 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D18 compound treatment 1.267332E7 564000.0 0.32 1.28916E7 28700.0 0.02 0.2353 0.7423 3188786 PK04_107078 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D19 compound treatment 1.199576E7 -114000.0 -0.06 1.288688E7 24000.0 0.01 -0.0357 -0.5457 3188787 PK04_107079 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D20 compound treatment 1.267188E7 562000.0 0.32 1.245968E7 -403000.0 -0.23 0.0628 0.1615 3070641 PK04_107080 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D21 compound treatment 1.149432E7 -615000.0 -0.35 1.255892E7 -304000.0 -0.17 -0.3654 -0.9474 3188905 PK04_107081 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D22 compound treatment 1.1745E7 -365000.0 -0.2 1.24044E7 -458000.0 -0.26 -0.3273 -0.9935 3188906 PK04_107082 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D23 compound treatment 1.125988E7 -850000.0 -0.48 1.253432E7 -329000.0 -0.18 -0.4683 -0.9148 3070684 PK04_107083 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 D24 compound treatment 9831160.0 -2280000.0 -1.28 1.083752E7 -2030000.0 -1.14 -1.7111 -0.9983 3188907 PK04_107084 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E01 mock treatment 1.158836E7 -521000.0 -0.29 1.166304E7 -1200000.0 -0.68 -0.6847 -0.93 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E02 mock treatment 1.18558E7 -254000.0 -0.14 1.294752E7 84700.0 0.05 -0.0672 -0.4466 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E03 compound treatment 1.110872E7 -1000000.0 -0.56 1.049012E7 -2370000.0 -1.34 -1.342 -0.9261 3220739 PK04_107085 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E04 compound treatment 1.098748E7 -1120000.0 -0.63 7879920.0 -4980000.0 -2.8 -2.4291 -0.8449 3070690 PK04_107086 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C(=C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E05 compound treatment 1.177656E7 -333000.0 -0.19 1.228276E7 -580000.0 -0.33 -0.3632 -0.9651 3220741 PK04_107087 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCC4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E06 compound treatment 1.18324E7 -277000.0 -0.16 1.177464E7 -1090000.0 -0.61 -0.5433 -0.8596 3070694 PK04_107088 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E07 compound treatment 1.252592E7 416000.0 0.23 1.222292E7 -640000.0 -0.36 -0.0894 -0.2083 3220743 PK04_107089 COCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)N4CCOCC4)c(C(=O)OC)c3C(=O)OC)nn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E08 compound treatment 1.260632E7 497000.0 0.28 1.27608E7 -102000.0 -0.06 0.1566 0.5499 3188910 PK04_107090 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)c5ccc(o5)c6ccc(Cl)c(Cl)c6)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E09 mock treatment 1.204228E7 -67500.0 -0.04 1.309292E7 230000.0 0.13 0.0648 0.48 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E10 mock treatment 1.248184E7 372000.0 0.21 1.225536E7 -607000.0 -0.34 -0.094 -0.2346 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E11 compound treatment 1.247656E7 367000.0 0.21 1.296296E7 100000.0 0.06 0.1855 0.8686 3188911 PK04_107091 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E12 compound treatment 1.273904E7 629000.0 0.35 1.333232E7 469000.0 0.26 0.4368 0.9897 3070742 PK04_107092 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E13 compound treatment 1.367864E7 1570000.0 0.88 1.557984E7 2720000.0 1.53 1.7046 0.9657 3188912 PK04_107093 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](C)Cn3cc(CN(C)C2=O)nn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E14 compound treatment 1.27606E7 651000.0 0.37 1.45694E7 1710000.0 0.96 0.9378 0.9124 3070746 PK04_107094 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E15 compound treatment 1.222356E7 114000.0 0.06 1.313364E7 271000.0 0.15 0.153 0.9255 3188913 PK04_107095 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E16 compound treatment 1.203208E7 -77700.0 -0.04 1.1814E7 -1050000.0 -0.59 -0.4483 -0.7573 3070750 PK04_107096 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E17 mock treatment 1.192404E7 -186000.0 -0.1 1.401412E7 1150000.0 0.65 0.3845 0.5858 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E18 mock treatment 1.194244E7 -167000.0 -0.09 1.257892E7 -284000.0 -0.16 -0.1795 -0.968 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E19 compound treatment 1.328288E7 1170000.0 0.66 1.31734E7 311000.0 0.17 0.5895 0.8648 3220747 PK04_107097 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCCC2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E20 compound treatment 1.151768E7 -592000.0 -0.33 1.285636E7 -6490.0 0.0 -0.2377 -0.7148 3188915 PK04_107098 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E21 compound treatment 1.148332E7 -626000.0 -0.35 1.281992E7 -42900.0 -0.02 -0.2659 -0.7539 3220749 PK04_107099 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCC(C)C)oc(C(=O)Cc2ccccc2)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E22 compound treatment 1.12752E7 -835000.0 -0.47 1.237084E7 -492000.0 -0.28 -0.5273 -0.9685 3070803 PK04_107100 CC(C)[Si](O[Si](C#Cc1ccc(Oc2ccccc2)cc1)(C(C)C)C(C)C)(C#Cc3ccc(Oc4ccccc4)cc3)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E23 compound treatment 1.207988E7 -29900.0 -0.02 1.19814E7 -881000.0 -0.5 -0.3627 -0.7306 3220751 PK04_107101 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2ccc(OC)cc2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 E24 compound treatment 1.115784E7 -952000.0 -0.53 1.129284E7 -1570000.0 -0.88 -1.003 -0.971 3070808 PK04_107102 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)c6ccccc6)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F01 mock treatment 1.140304E7 -707000.0 -0.4 1.162072E7 -1240000.0 -0.7 -0.7751 -0.964 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F02 mock treatment 1.15498E7 -560000.0 -0.31 1.233352E7 -529000.0 -0.3 -0.4331 -0.9996 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F03 compound treatment 1.166048E7 -449000.0 -0.25 1.261632E7 -247000.0 -0.14 -0.2766 -0.9603 3188918 PK04_107103 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F04 compound treatment 1.1831E7 -279000.0 -0.16 1.212332E7 -740000.0 -0.42 -0.4051 -0.9108 3188919 PK04_107104 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F05 compound treatment 1.212396E7 14200.0 0.01 1.312892E7 266000.0 0.15 0.1115 0.7437 3188920 PK04_107105 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F06 compound treatment 1.287252E7 763000.0 0.43 1.311348E7 251000.0 0.14 0.4027 0.8928 3188921 PK04_107106 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F07 compound treatment 1.247096E7 361000.0 0.2 1.326592E7 403000.0 0.23 0.3039 0.9984 3070852 PK04_107107 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F08 compound treatment 1.27702E7 660000.0 0.37 1.306024E7 197000.0 0.11 0.3409 0.8803 3188922 PK04_107108 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F09 mock treatment 1.275284E7 643000.0 0.36 1.266364E7 -199000.0 -0.11 0.1761 0.4657 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F10 mock treatment 1.350324E7 1390000.0 0.78 1.323684E7 374000.0 0.21 0.7023 0.8665 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F11 compound treatment 1.283472E7 725000.0 0.41 1.325016E7 387000.0 0.22 0.4421 0.9571 3189029 PK04_107109 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F12 compound treatment 1.266008E7 550000.0 0.31 1.344908E7 586000.0 0.33 0.4519 0.9995 3070859 PK04_107110 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F13 compound treatment 1.37766E7 1670000.0 0.94 1.322088E7 358000.0 0.2 0.8045 0.8401 3189030 PK04_107111 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F14 compound treatment 1.244184E7 332000.0 0.19 1.359584E7 733000.0 0.41 0.4237 0.9356 3189031 PK04_107112 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F15 compound treatment 1.270004E7 590000.0 0.33 1.305832E7 195000.0 0.11 0.3122 0.8938 3070862 PK04_107113 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F16 compound treatment 1.208964E7 -20100.0 -0.01 1.3172E7 309000.0 0.17 0.1151 0.6598 3189032 PK04_107114 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F17 mock treatment 1.28388E7 729000.0 0.41 1.321872E7 356000.0 0.2 0.4312 0.9459 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F18 mock treatment 1.20664E7 -43400.0 -0.02 1.332292E7 460000.0 0.26 0.1659 0.6378 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F19 compound treatment 1.233848E7 229000.0 0.13 1.27276E7 -135000.0 -0.08 0.037 0.2478 3189033 PK04_107115 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F20 compound treatment 1.149916E7 -611000.0 -0.34 1.241692E7 -446000.0 -0.25 -0.42 -0.9882 3070022 PK04_107116 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F21 compound treatment 1.181156E7 -298000.0 -0.17 1.266608E7 -197000.0 -0.11 -0.1968 -0.9798 3189034 PK04_107117 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F22 compound treatment 1.10076E7 -1100000.0 -0.62 1.253964E7 -323000.0 -0.18 -0.5664 -0.8778 3189035 PK04_107118 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F23 compound treatment 1.046136E7 -1650000.0 -0.93 1.169504E7 -1170000.0 -0.66 -1.1195 -0.9859 3070031 PK04_107119 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 F24 compound treatment 1.028644E7 -1820000.0 -1.02 1.102764E7 -1840000.0 -1.03 -1.4546 -1.0 3189036 PK04_107120 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G01 compound treatment 1.12868E7 -823000.0 -0.46 1.22234E7 -639000.0 -0.36 -0.5814 -0.9924 3220772 PK04_107121 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCc2c[nH]c3ccccc23)oc(C(=O)Cc4ccccc4)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G02 compound treatment 1.191792E7 -192000.0 -0.11 1.24196E7 -443000.0 -0.25 -0.2526 -0.9295 3070078 PK04_107122 CC[C@@H]1O[Si](C(C)C)(C(C)C)c2c1cc(nc2c3ccc(Oc4ccccc4)cc3)c5cc(C)c(OC)c(C)c5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G03 mock treatment 1.183248E7 -277000.0 -0.16 1.252796E7 -335000.0 -0.19 -0.2434 -0.9955 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G04 mock treatment 1.26828E7 573000.0 0.32 1.293796E7 75100.0 0.04 0.2575 0.7932 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G05 compound treatment 1.2312E7 202000.0 0.11 1.270148E7 -161000.0 -0.09 0.0161 0.1106 3220775 PK04_107123 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2nc[nH]n2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G06 compound treatment 1.365116E7 1540000.0 0.87 1.28306E7 -32300.0 -0.02 0.5994 0.6921 3070081 PK04_107124 CC(C)[Si]1(OCc2c1c(nc(c3ccc(o3)c4ccc(Cl)c(Cl)c4)c2C)c5ccccc5)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G07 compound treatment 1.371864E7 1610000.0 0.9 1.310244E7 240000.0 0.13 0.7344 0.8037 3189039 PK04_107125 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G08 compound treatment 1.387852E7 1770000.0 0.99 1.30764E7 214000.0 0.12 0.7875 0.7869 3189040 PK04_107126 COc1c(C)cc(cc1C)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G09 compound treatment 1.257172E7 462000.0 0.26 1.280316E7 -59700.0 -0.03 0.1597 0.6104 3070086 PK04_107127 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(CCCNC(=N)N)nn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G10 compound treatment 1.301272E7 903000.0 0.51 1.2021E7 -842000.0 -0.47 0.0235 0.0339 3189041 PK04_107128 COc1ccc(cn1)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G11 compound treatment 1.334812E7 1240000.0 0.7 1.393308E7 1070000.0 0.6 0.9178 0.9974 3070089 PK04_107129 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G12 compound treatment 1.252636E7 417000.0 0.23 1.22012E7 -662000.0 -0.37 -0.0979 -0.2226 3189042 PK04_107130 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G13 compound treatment 1.399456E7 1880000.0 1.06 1.415588E7 1290000.0 0.73 1.2633 0.9833 3070134 PK04_107131 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)C3(O)CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G14 compound treatment 1.309136E7 982000.0 0.55 1.407408E7 1210000.0 0.68 0.872 0.9945 3070137 PK04_107132 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G15 compound treatment 1.272772E7 618000.0 0.35 1.32642E7 401000.0 0.23 0.4052 0.9784 3189043 PK04_107133 N[C@@H](Cc1ccccc1)Cn2cc(nn2)C3(O)CCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G16 compound treatment 1.257224E7 462000.0 0.26 1.280844E7 -54400.0 -0.03 0.162 0.6194 3189044 PK04_107134 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G17 compound treatment 1.290388E7 794000.0 0.45 1.314636E7 284000.0 0.16 0.4282 0.904 3070143 PK04_107135 N[C@@H](Cc1ccccc1)Cn2cc(nn2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G18 compound treatment 1.222036E7 111000.0 0.06 1.476536E7 1900000.0 1.07 0.8012 0.7469 3189045 PK04_107136 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)C4CC4)c5ccccc5)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G19 mock treatment 1.256172E7 452000.0 0.25 1.266904E7 -194000.0 -0.11 0.1024 0.3705 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G20 mock treatment 1.241536E7 306000.0 0.17 1.271356E7 -149000.0 -0.08 0.062 0.3242 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G21 compound treatment 1.183404E7 -276000.0 -0.15 1.24276E7 -435000.0 -0.25 -0.2828 -0.9755 3070191 PK04_107137 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(Cc3ccccc3)nn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G22 compound treatment 1.148404E7 -626000.0 -0.35 1.217128E7 -692000.0 -0.39 -0.5238 -0.9987 3189046 PK04_107138 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G23 compound treatment 1.207608E7 -33700.0 -0.02 1.220076E7 -662000.0 -0.37 -0.2769 -0.742 3070196 PK04_107139 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 G24 compound treatment 1.16702E7 -440000.0 -0.25 1.166024E7 -1200000.0 -0.68 -0.6533 -0.9066 3189047 PK04_107140 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H01 compound treatment 1.236416E7 254000.0 0.14 1.273636E7 -126000.0 -0.07 0.0507 0.3175 3189157 PK04_107141 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H02 compound treatment 1.184032E7 -269000.0 -0.15 1.293244E7 69600.0 0.04 -0.0793 -0.5074 3189158 PK04_107142 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H03 mock treatment 1.195512E7 -155000.0 -0.09 1.21354E7 -727000.0 -0.41 -0.351 -0.8384 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H04 mock treatment 1.238196E7 272000.0 0.15 1.239088E7 -472000.0 -0.27 -0.0798 -0.2602 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H05 compound treatment 1.248952E7 380000.0 0.21 1.268844E7 -174000.0 -0.1 0.0814 0.3467 3070201 PK04_107143 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H06 compound treatment 1.198244E7 -127000.0 -0.07 1.239628E7 -467000.0 -0.26 -0.2363 -0.868 3189159 PK04_107144 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H07 compound treatment 1.24078E7 298000.0 0.17 1.280816E7 -54700.0 -0.03 0.0966 0.5676 3071172 PK04_107145 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H08 compound treatment 1.187008E7 -240000.0 -0.13 1.228888E7 -574000.0 -0.32 -0.3237 -0.9247 3071173 PK04_107146 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H09 compound treatment 1.203196E7 -77800.0 -0.04 1.256848E7 -294000.0 -0.17 -0.1481 -0.864 3071174 PK04_107147 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H10 compound treatment 1.212792E7 18200.0 0.01 1.256632E7 -297000.0 -0.17 -0.1108 -0.6626 3189160 PK04_107148 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H11 compound treatment 1.3069E7 959000.0 0.54 1.301852E7 156000.0 0.09 0.4429 0.8114 3189161 PK04_107149 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H12 compound treatment 1.34006E7 1290000.0 0.73 1.296444E7 102000.0 0.06 0.5531 0.7605 3071175 PK04_107150 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H13 compound treatment 1.472876E7 2620000.0 1.47 1.463764E7 1770000.0 1.0 1.7466 0.9822 3189162 PK04_107151 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H14 compound treatment 1.206724E7 -42500.0 -0.02 1.30318E7 169000.0 0.1 0.0504 0.5136 3189163 PK04_107152 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H15 compound treatment 1.246412E7 354000.0 0.2 1.129596E7 -1570000.0 -0.88 -0.4829 -0.5341 3071176 PK04_107153 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H16 compound treatment 1.24786E7 369000.0 0.21 1.357624E7 713000.0 0.4 0.4304 0.9526 3189164 PK04_107154 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H17 compound treatment 1.227016E7 160000.0 0.09 1.301092E7 148000.0 0.08 0.1226 0.9992 3189165 PK04_107155 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H18 compound treatment 1.266624E7 556000.0 0.31 1.302352E7 161000.0 0.09 0.285 0.8758 3071177 PK04_107156 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H19 mock treatment 1.227468E7 165000.0 0.09 1.285948E7 -3370.0 0.0 0.0642 0.6925 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H20 mock treatment 1.064048E7 -1470000.0 -0.83 1.35054E7 643000.0 0.36 -0.3278 -0.3638 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H21 compound treatment 1.1832E7 -278000.0 -0.16 1.287448E7 11600.0 0.01 -0.1057 -0.6768 3189166 PK04_107157 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H22 compound treatment 1.109984E7 -1010000.0 -0.57 1.260284E7 -260000.0 -0.15 -0.5046 -0.8613 3189167 PK04_107158 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H23 compound treatment 1.162928E7 -480000.0 -0.27 1.265972E7 -203000.0 -0.11 -0.2717 -0.9269 3071178 PK04_107159 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 H24 compound treatment 1.154604E7 -564000.0 -0.32 1.106472E7 -1800000.0 -1.01 -0.9396 -0.886 3189168 PK04_107160 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I01 compound treatment 1.147016E7 -640000.0 -0.36 1.187E7 -993000.0 -0.56 -0.6492 -0.9772 3071179 PK04_107161 CC(C)[C@@H](C(=O)O)n1cc(nn1)C2(O)CCCCC2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I02 compound treatment 1.163484E7 -475000.0 -0.27 1.203272E7 -830000.0 -0.47 -0.519 -0.9646 3189169 PK04_107162 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I03 compound treatment 1.159548E7 -514000.0 -0.29 1.181864E7 -1040000.0 -0.59 -0.6199 -0.9465 3071180 PK04_107163 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I04 compound treatment 1.148456E7 -625000.0 -0.35 1.132372E7 -1540000.0 -0.87 -0.8609 -0.9209 3189170 PK04_107164 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I05 mock treatment 1.18192E7 -291000.0 -0.16 1.201708E7 -846000.0 -0.48 -0.452 -0.8982 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I06 mock treatment 1.173812E7 -372000.0 -0.21 1.261044E7 -252000.0 -0.14 -0.2481 -0.9824 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I07 compound treatment 1.267604E7 566000.0 0.32 1.238592E7 -477000.0 -0.27 0.0351 0.0843 3071181 PK04_107165 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@]4(O[C@@]23[C@H]5[C@@H]4C(=O)N(C)C5=O)C(=O)C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I08 compound treatment 1.247864E7 369000.0 0.21 1.249088E7 -372000.0 -0.21 -0.0015 -0.0053 3189171 PK04_107166 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I09 compound treatment 1.26758E7 566000.0 0.32 1.3382E7 519000.0 0.29 0.4315 0.9991 3189172 PK04_107167 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@@]4(O[C@]23[C@@H]5[C@H]4C(=O)N(C)C5=O)C(=O)C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I10 compound treatment 1.289408E7 784000.0 0.44 1.3001E7 138000.0 0.08 0.3665 0.8193 3071182 PK04_107168 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I11 compound treatment 1.247804E7 368000.0 0.21 1.319996E7 337000.0 0.19 0.2805 0.9991 3189173 PK04_107169 NC(=N)NCc1cn(CCc2c[nH]c3ccccc23)nn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I12 compound treatment 1.268288E7 573000.0 0.32 1.336404E7 501000.0 0.28 0.4271 0.9978 3189286 PK04_107170 CC(C)[Si]1(O[C@H](c2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I13 compound treatment 1.238812E7 278000.0 0.16 1.290588E7 43000.0 0.02 0.1277 0.807 3071183 PK04_107171 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@H](Cc4ccccc4)C(=O)N23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I14 compound treatment 1.213916E7 29400.0 0.02 1.295796E7 95100.0 0.05 0.0495 0.8841 3189287 PK04_107172 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I15 compound treatment 1.251088E7 401000.0 0.23 1.294688E7 84000.0 0.05 0.1928 0.8373 3071184 PK04_107173 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@@H](Cc4ccccc4)C(=O)N23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I16 compound treatment 1.22686E7 159000.0 0.09 1.304976E7 187000.0 0.11 0.1375 0.9966 3189288 PK04_107174 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I17 compound treatment 1.24822E7 372000.0 0.21 1.301088E7 148000.0 0.08 0.2068 0.9186 3071185 PK04_107175 COc1ccc(cc1)[C@H]2OC[C@@H]3CC4(CC=CC4)C(=O)N23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I18 compound treatment 1.19402E7 -170000.0 -0.1 1.296652E7 104000.0 0.06 -0.0261 -0.2335 3189289 PK04_107176 COc1cc(Cc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I19 compound treatment 1.2966E7 856000.0 0.48 1.262008E7 -243000.0 -0.14 0.2434 0.4869 3071186 PK04_107177 COc1ccc(cc1)[C@H]2OC[C@@H]3CCC(=O)N23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I20 compound treatment 1.06778E7 -1430000.0 -0.8 1.227004E7 -593000.0 -0.33 -0.8047 -0.9241 3189171 PK04_107178 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I21 mock treatment 1.090188E7 -1210000.0 -0.68 1.232652E7 -536000.0 -0.3 -0.6932 -0.9335 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I22 mock treatment 1.118864E7 -921000.0 -0.52 1.19318E7 -931000.0 -0.52 -0.7364 -1.0 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I23 compound treatment 1.137804E7 -732000.0 -0.41 1.297364E7 111000.0 0.06 -0.2465 -0.593 3189290 PK04_107179 COc1ccc(cc1)[C@H]2OC[C@@H]3CC(CC=C)(CC=C)C(=O)N23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 I24 compound treatment 1.091756E7 -1190000.0 -0.67 1.116596E7 -1700000.0 -0.96 -1.1489 -0.9849 3071182 PK04_107180 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J01 compound treatment 1.065356E7 -1460000.0 -0.82 1.091768E7 -1950000.0 -1.09 -1.3526 -0.9897 3189291 PK04_107181 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J02 compound treatment 1.104036E7 -1070000.0 -0.6 1.120776E7 -1660000.0 -0.93 -1.0835 -0.9775 3071187 PK04_107182 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J03 compound treatment 1.08204E7 -1290000.0 -0.72 1.212936E7 -733000.0 -0.41 -0.804 -0.9645 3189292 PK04_107183 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J04 compound treatment 1.159884E7 -511000.0 -0.29 1.146964E7 -1390000.0 -0.78 -0.7575 -0.907 3189293 PK04_107184 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J05 mock treatment 1.209628E7 -13500.0 -0.01 1.301524E7 152000.0 0.09 0.0553 0.6422 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J06 mock treatment 1.18044E7 -305000.0 -0.17 1.28644E7 1550.0 0.0 -0.1207 -0.7035 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J07 compound treatment 1.35976E7 1490000.0 0.84 1.26598E7 -203000.0 -0.11 0.5101 0.6048 3071188 PK04_107185 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J08 compound treatment 1.129156E7 -818000.0 -0.46 1.214552E7 -717000.0 -0.4 -0.6105 -0.9979 3189294 PK04_107186 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J09 compound treatment 1.243E7 320000.0 0.18 1.239388E7 -469000.0 -0.26 -0.0595 -0.1862 3189295 PK04_107187 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J10 compound treatment 1.208048E7 -29300.0 -0.02 1.270616E7 -157000.0 -0.09 -0.074 -0.8247 3071189 PK04_107188 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J11 compound treatment 1.27538E7 644000.0 0.36 1.326152E7 399000.0 0.22 0.4145 0.9736 3189296 PK04_107189 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J12 compound treatment 1.233752E7 228000.0 0.13 1.50536E7 2190000.0 1.23 0.9625 0.7763 3189297 PK04_107190 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J13 compound treatment 1.350896E7 1400000.0 0.79 1.548204E7 2620000.0 1.47 1.5983 0.9566 3071190 PK04_107191 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J14 compound treatment 1.255892E7 449000.0 0.25 1.432868E7 1470000.0 0.83 0.7618 0.883 3189298 PK04_107192 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J15 compound treatment 1.191344E7 -196000.0 -0.11 1.282772E7 -35100.0 -0.02 -0.092 -0.8208 3071191 PK04_107193 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J16 compound treatment 1.167392E7 -436000.0 -0.24 1.308792E7 225000.0 0.13 -0.0835 -0.303 3189299 PK04_107194 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J17 compound treatment 1.138756E7 -722000.0 -0.41 1.355956E7 697000.0 0.39 -0.0095 -0.0169 3189300 PK04_107195 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J18 compound treatment 1.085388E7 -1260000.0 -0.71 1.196384E7 -899000.0 -0.51 -0.8566 -0.9867 3071192 PK04_107196 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J19 compound treatment 1.266628E7 557000.0 0.31 1.463984E7 1780000.0 1.0 0.9283 0.8858 3189301 PK04_107197 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J20 compound treatment 1.107188E7 -1040000.0 -0.58 1.260384E7 -259000.0 -0.15 -0.5153 -0.8575 3189302 PK04_107198 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J21 mock treatment 1.124772E7 -862000.0 -0.48 1.273432E7 -129000.0 -0.07 -0.3935 -0.8038 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J22 mock treatment 1.128908E7 -821000.0 -0.46 1.34566E7 594000.0 0.33 -0.0896 -0.1574 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J23 compound treatment 1.098552E7 -1120000.0 -0.63 1.182344E7 -1040000.0 -0.59 -0.8602 -0.9993 3071251 PK04_107199 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 J24 compound treatment 9489000.0 -2620000.0 -1.47 1.112848E7 -1730000.0 -0.98 -1.7312 -0.9801 3189414 PK04_107200 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K01 compound treatment 1.077212E7 -1340000.0 -0.75 1.13632E7 -1500000.0 -0.84 -1.1282 -0.9983 3071252 PK04_107201 COc1cccc(C[C@H]2C[C@@H](CO)NC2=O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K02 compound treatment 1.217736E7 67600.0 0.04 1.138972E7 -1470000.0 -0.83 -0.5595 -0.674 3189415 PK04_107202 CCCCCCC#C[Si](O[C@@H](C#C)c1ccccc1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K03 compound treatment 1.092924E7 -1180000.0 -0.66 1.125696E7 -1610000.0 -0.9 -1.1081 -0.9884 3071253 PK04_107203 COC(=O)c1c(CC[C@@H](CO)NC(=O)N(C)Cc2ccccc2)oc(C(=O)OCC=C)c1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K04 compound treatment 1.11756E7 -934000.0 -0.52 1.169568E7 -1170000.0 -0.66 -0.8356 -0.9938 3189416 PK04_107204 CCCCCCC#C[Si](OCC#CC)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K05 compound treatment 1.1444E7 -666000.0 -0.37 1.217892E7 -684000.0 -0.38 -0.5366 -0.9999 3189417 PK04_107205 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(COC2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K06 compound treatment 1.190848E7 -201000.0 -0.11 1.155808E7 -1300000.0 -0.73 -0.5993 -0.8064 3071254 PK04_107206 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccccc2)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K07 mock treatment 1.21052E7 -4550.0 0.0 1.194304E7 -920000.0 -0.52 -0.3679 -0.7106 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K08 mock treatment 1.187004E7 -240000.0 -0.13 1.378556E7 923000.0 0.52 0.2721 0.507 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K09 compound treatment 1.174052E7 -369000.0 -0.21 1.26472E7 -216000.0 -0.12 -0.2325 -0.9675 3071255 PK04_107207 NC(=N)NCC#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K10 compound treatment 1.264412E7 534000.0 0.3 1.269488E7 -168000.0 -0.09 0.1454 0.462 3189418 PK04_107208 CC#CCO[Si](C#Cc1ccccc1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K11 compound treatment 1.227176E7 162000.0 0.09 1.289636E7 33500.0 0.02 0.0777 0.8359 3189419 PK04_107209 OC(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K12 compound treatment 1.190588E7 -204000.0 -0.11 1.318132E7 318000.0 0.18 0.0458 0.2153 3071256 PK04_107210 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccc(Oc3ccccc3)cc2)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K13 compound treatment 1.290148E7 792000.0 0.44 1.216784E7 -695000.0 -0.39 0.0378 0.0638 3189420 PK04_107211 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@](Cc4ccccc4)(C(=O)OCC=C)C(=O)N23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K14 compound treatment 1.258396E7 474000.0 0.27 1.306952E7 207000.0 0.12 0.2706 0.931 3071257 PK04_107212 CC[C@@H](O[Si](C#Cc1ccc(Oc2ccccc2)cc1)(C(C)C)C(C)C)C#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K15 mock treatment 1.160088E7 -509000.0 -0.29 1.260216E7 -261000.0 -0.15 -0.3059 -0.952 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K16 mock treatment 1.212164E7 11900.0 0.01 1.235056E7 -512000.0 -0.29 -0.1992 -0.6906 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K17 compound treatment 1.17142E7 -396000.0 -0.22 1.187244E7 -990000.0 -0.56 -0.5513 -0.9186 1035256 PK04_107213 C#CCNCc1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K18 compound treatment 1.286632E7 757000.0 0.42 1.232824E7 -535000.0 -0.3 0.0877 0.1684 3189421 PK04_107214 CC(C)[Si](Oc1ccccc1Br)(C#CCCCC#N)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K19 compound treatment 1.120992E7 -900000.0 -0.51 1.216776E7 -695000.0 -0.39 -0.6341 -0.992 3071258 PK04_107215 CC(C)[C@H](N=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K20 compound treatment 1.111136E7 -998000.0 -0.56 1.131468E7 -1550000.0 -0.87 -1.0128 -0.9773 3189422 PK04_107216 CC[C@@H](O[Si](C#CCCCC#N)(C(C)C)C(C)C)C#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K21 compound treatment 1.094536E7 -1160000.0 -0.65 1.206696E7 -796000.0 -0.45 -0.7793 -0.983 3189423 PK04_107217 [N-]=[N+]=NC[C@H](Cc1ccccc1)NC(=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K22 compound treatment 1.130584E7 -804000.0 -0.45 1.167704E7 -1190000.0 -0.67 -0.7913 -0.9819 3071259 PK04_107218 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#Cc4ccccc4)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K23 mock treatment 1.133884E7 -771000.0 -0.43 1.22626E7 -600000.0 -0.34 -0.5451 -0.9925 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 K24 mock treatment 1.098756E7 -1120000.0 -0.63 1.114564E7 -1720000.0 -0.97 -1.1292 -0.9785 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L01 compound treatment 1.18978E7 -212000.0 -0.12 1.184532E7 -1020000.0 -0.57 -0.4892 -0.8362 3189424 PK04_107219 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L02 compound treatment 1.126296E7 -847000.0 -0.48 1.264064E7 -222000.0 -0.13 -0.4248 -0.8637 3189425 PK04_107220 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L03 compound treatment 1.124608E7 -864000.0 -0.49 1.15936E7 -1270000.0 -0.71 -0.8482 -0.9822 3071260 PK04_107221 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L04 compound treatment 1.168772E7 -422000.0 -0.24 1.178908E7 -1070000.0 -0.6 -0.595 -0.9165 3189426 PK04_107222 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L05 compound treatment 1.193444E7 -175000.0 -0.1 1.20938E7 -769000.0 -0.43 -0.3757 -0.8463 3189427 PK04_107223 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L06 compound treatment 1.198196E7 -128000.0 -0.07 1.498364E7 2120000.0 1.19 0.7934 0.6634 3071261 PK04_107224 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L07 mock treatment 1.230928E7 200000.0 0.11 1.26986E7 -164000.0 -0.09 0.0139 0.0954 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L08 mock treatment 1.267584E7 566000.0 0.32 1.273932E7 -124000.0 -0.07 0.1757 0.5397 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L09 compound treatment 1.242E7 310000.0 0.17 1.366468E7 802000.0 0.45 0.4424 0.9143 3189428 PK04_107225 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L10 compound treatment 1.221716E7 107000.0 0.06 1.285832E7 -4530.0 0.0 0.0409 0.6766 3189429 PK04_107226 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L11 compound treatment 1.262088E7 511000.0 0.29 1.304588E7 183000.0 0.1 0.2759 0.9044 3071262 PK04_107227 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L12 compound treatment 1.110904E7 -1000000.0 -0.56 1.255604E7 -307000.0 -0.17 -0.5196 -0.8836 3189430 PK04_107228 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L13 compound treatment 1.402496E7 1920000.0 1.08 1.310484E7 242000.0 0.14 0.857 0.7903 3189431 PK04_107229 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L14 compound treatment 1.217276E7 63000.0 0.04 1.332852E7 466000.0 0.26 0.2104 0.7954 3071263 PK04_107230 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L15 mock treatment 1.247756E7 368000.0 0.21 1.313012E7 267000.0 0.15 0.2525 0.9879 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L16 mock treatment 1.220344E7 93700.0 0.05 1.295768E7 94800.0 0.05 0.075 1.0 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L17 compound treatment 1.234832E7 239000.0 0.13 1.296988E7 107000.0 0.06 0.1374 0.9349 3189432 PK04_107231 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L18 compound treatment 1.220568E7 95900.0 0.05 1.287984E7 17000.0 0.01 0.0449 0.8198 3189547 PK04_107232 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L19 compound treatment 1.319448E7 1080000.0 0.61 1.294972E7 86900.0 0.05 0.4654 0.7614 3071264 PK04_107233 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L20 compound treatment 1.12076E7 -902000.0 -0.51 1.147064E7 -1390000.0 -0.78 -0.9125 -0.9777 3189548 PK04_107234 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L21 compound treatment 1.125936E7 -850000.0 -0.48 1.277536E7 -87500.0 -0.05 -0.3726 -0.7759 3189549 PK04_107235 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L22 compound treatment 1.09966E7 -1110000.0 -0.63 1.24556E7 -407000.0 -0.23 -0.6042 -0.9073 3071265 PK04_107236 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L23 mock treatment 1.079172E7 -1320000.0 -0.74 1.199376E7 -869000.0 -0.49 -0.8694 -0.9798 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 L24 mock treatment 1.019968E7 -1910000.0 -1.07 1.134144E7 -1520000.0 -0.86 -1.3642 -0.9938 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M01 compound treatment 1.06638E7 -1450000.0 -0.81 1.174908E7 -1110000.0 -0.63 -1.0176 -0.9918 3189550 PK04_107237 COc1cccc(C[C@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M02 compound treatment 1.138968E7 -720000.0 -0.4 1.14982E7 -1360000.0 -0.77 -0.8292 -0.9551 3071266 PK04_107238 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCc4ccccc4)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M03 compound treatment 1.1047E7 -1060000.0 -0.6 1.034392E7 -2520000.0 -1.42 -1.4247 -0.9261 3189551 PK04_107239 COc1cccc(C[C@@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M04 compound treatment 1.169552E7 -414000.0 -0.23 1.219992E7 -663000.0 -0.37 -0.4284 -0.9741 3189552 PK04_107240 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M05 compound treatment 1.253596E7 426000.0 0.24 1.2522E7 -341000.0 -0.19 0.0336 0.1095 3071267 PK04_107241 CN(C)S(=O)(=O)NCC#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M06 compound treatment 1.201664E7 -93100.0 -0.05 1.28196E7 -43300.0 -0.02 -0.0542 -0.9395 3189553 PK04_107242 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](CO)Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M07 compound treatment 1.20158E7 -94000.0 -0.05 1.1807E7 -1060000.0 -0.59 -0.4576 -0.7669 3414058 PK04_107243 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M08 compound treatment 1.233508E7 225000.0 0.13 1.279604E7 -66800.0 -0.04 0.0629 0.4764 3189554 PK04_107244 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(Cc2cccc(Cl)c2)nn1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M09 mock treatment 1.198508E7 -125000.0 -0.07 1.288508E7 22200.0 0.01 -0.0407 -0.5717 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M10 mock treatment 1.214896E7 39200.0 0.02 1.320548E7 343000.0 0.19 0.152 0.7828 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M11 compound treatment 1.232292E7 213000.0 0.12 1.41816E7 1320000.0 0.74 0.6096 0.8107 3189555 PK04_107245 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M12 compound treatment 1.245064E7 341000.0 0.19 1.31828E7 320000.0 0.18 0.2627 0.9995 3071269 PK04_107246 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M13 mock treatment 1.339136E7 1280000.0 0.72 1.310916E7 246000.0 0.14 0.6071 0.8281 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M14 mock treatment 1.25278E7 418000.0 0.23 1.328212E7 419000.0 0.24 0.3329 1.0 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M15 compound treatment 1.249008E7 380000.0 0.21 1.299392E7 131000.0 0.07 0.2032 0.8992 3189556 PK04_107247 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M16 compound treatment 1.242316E7 313000.0 0.18 1.262328E7 -240000.0 -0.13 0.0291 0.1313 3189557 PK04_107248 CCCC#C[Si](O[C@H](CC)c1cn(Cc2ccccc2)nn1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M17 compound treatment 1.193636E7 -173000.0 -0.1 1.352588E7 663000.0 0.37 0.195 0.5057 3189558 PK04_107249 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H](Cc5ccccc5)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M18 compound treatment 1.178064E7 -329000.0 -0.18 1.268248E7 -180000.0 -0.1 -0.2025 -0.9602 3071329 PK04_107250 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M19 compound treatment 1.14536E7 -656000.0 -0.37 1.258908E7 -274000.0 -0.15 -0.3696 -0.9252 3189559 PK04_107251 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H]5CCCN5C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M20 compound treatment 1.138648E7 -723000.0 -0.41 1.270648E7 -156000.0 -0.09 -0.3495 -0.8408 3071330 PK04_107252 CCCC#C[Si](O[C@H](CC)c1cn(Cc2cccc(Cl)c2)nn1)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M21 compound treatment 1.039048E7 -1720000.0 -0.97 1.242176E7 -441000.0 -0.25 -0.8584 -0.8609 3189560 PK04_107253 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H]5CCCN5C2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M22 compound treatment 1.146048E7 -649000.0 -0.36 1.18432E7 -1020000.0 -0.57 -0.6637 -0.976 3071331 PK04_107254 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](C)c2ccccc2)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M23 compound treatment 1.105448E7 -1060000.0 -0.59 1.162832E7 -1230000.0 -0.69 -0.9105 -0.9969 3189561 PK04_107255 CN1Cc2cn(C[C@H](Cc3ccccc3)NC(=O)c4cc(c(CC[C@@H](CO)NC1=O)o4)S(=O)(=O)c5ccc(C)cc5)nn2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 M24 compound treatment 1.046784E7 -1640000.0 -0.92 1.111144E7 -1750000.0 -0.99 -1.3492 -0.9994 3071332 PK04_107256 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N01 compound treatment 1.28922E7 782000.0 0.44 1.410216E7 1240000.0 0.7 0.8041 0.9752 3189562 PK04_107257 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N02 compound treatment 1.54174E7 3310000.0 1.86 1.353612E7 673000.0 0.38 1.5817 0.8342 3189563 PK04_107258 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N03 compound treatment 1.726828E7 5160000.0 2.9 1.290404E7 41200.0 0.02 2.0652 0.7127 3071333 PK04_107259 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N04 compound treatment 1.721128E7 5100000.0 2.87 1.33828E7 520000.0 0.29 2.2331 0.7753 3189564 PK04_107260 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N05 compound treatment 1.33006E7 1190000.0 0.67 1.239892E7 -464000.0 -0.26 0.2883 0.4015 3189681 PK04_107261 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N06 compound treatment 1.262056E7 511000.0 0.29 1.20558E7 -807000.0 -0.45 -0.1184 -0.2203 3071334 PK04_107262 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N07 compound treatment 1.381292E7 1700000.0 0.96 1.5135E7 2270000.0 1.28 1.5808 0.9898 3189682 PK04_107263 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N08 compound treatment 1.353192E7 1420000.0 0.8 1.35926E7 730000.0 0.41 0.8553 0.9522 3071335 PK04_107264 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N09 mock treatment 1.290628E7 797000.0 0.45 1.364636E7 784000.0 0.44 0.6282 1.0 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N10 mock treatment 1.298808E7 878000.0 0.49 1.401564E7 1150000.0 0.65 0.8077 0.9909 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N11 compound treatment 1.350016E7 1390000.0 0.78 1.390084E7 1040000.0 0.58 0.9654 0.9898 3189683 PK04_107265 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N12 compound treatment 1.852064E7 6410000.0 3.6 1.53148E7 2450000.0 1.38 3.5222 0.9133 3189684 PK04_107266 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N13 mock treatment 1.700848E7 4900000.0 2.75 1.397444E7 1110000.0 0.63 2.3881 0.8463 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N14 mock treatment 1.299568E7 886000.0 0.5 1.413184E7 1270000.0 0.71 0.857 0.9844 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N15 compound treatment 1.253548E7 426000.0 0.24 1.381464E7 952000.0 0.54 0.5479 0.9339 3071336 PK04_107267 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N16 compound treatment 1.304092E7 931000.0 0.52 1.361444E7 752000.0 0.42 0.669 0.9945 3189685 PK04_107268 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N17 compound treatment 1.223312E7 123000.0 0.07 1.378196E7 919000.0 0.52 0.4148 0.7947 3189686 PK04_107269 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N18 compound treatment 1.197056E7 -139000.0 -0.08 1.298196E7 119000.0 0.07 -0.0079 -0.0764 3071337 PK04_107270 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N19 compound treatment 1.177644E7 -333000.0 -0.19 1.321504E7 352000.0 0.2 0.0078 0.0286 3189687 PK04_107271 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N20 compound treatment 1.207944E7 -30300.0 -0.02 1.232696E7 -536000.0 -0.3 -0.2253 -0.7458 3189688 PK04_107272 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N21 compound treatment 1.098632E7 -1120000.0 -0.63 1.322192E7 359000.0 0.2 -0.3033 -0.4577 3071339 PK04_107273 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N22 compound treatment 1.380288E7 1690000.0 0.95 1.20296E7 -833000.0 -0.47 0.3408 0.3214 3189689 PK04_107274 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N23 compound treatment 1.295312E7 843000.0 0.47 1.263972E7 -223000.0 -0.13 0.2461 0.5023 3189690 PK04_107275 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 N24 compound treatment 1.063816E7 -1470000.0 -0.83 1.069088E7 -2170000.0 -1.22 -1.449 -0.9818 3071341 PK04_107276 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O01 compound treatment 1.121208E7 -898000.0 -0.5 1.2092E7 -771000.0 -0.43 -0.6634 -0.9972 3414059 PK04_107277 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(Cc5ccccc5)C2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O02 compound treatment 1.4179E7 2070000.0 1.16 1.400736E7 1140000.0 0.64 1.2774 0.9613 3189692 PK04_107278 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O03 compound treatment 1.163888E7 -471000.0 -0.26 1.231296E7 -550000.0 -0.31 -0.4059 -0.9969 3414060 PK04_107279 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(nn4)C5(CCCCC5)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O04 compound treatment 1.188332E7 -226000.0 -0.13 1.222392E7 -639000.0 -0.36 -0.3443 -0.9024 3189693 PK04_107280 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O05 compound treatment 1.184328E7 -266000.0 -0.15 1.427476E7 1410000.0 0.79 0.4562 0.564 3071393 PK04_107281 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cnnn3C[C@H](Cc4ccccc4)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O06 compound treatment 1.237052E7 261000.0 0.15 1.28744E7 11500.0 0.01 0.1082 0.7378 3189694 PK04_107282 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O07 compound treatment 1.36386E7 1530000.0 0.86 1.239836E7 -464000.0 -0.26 0.4223 0.4705 3189695 PK04_107283 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O08 compound treatment 1.21172E7 7450.0 0.0 1.29934E7 131000.0 0.07 0.0549 0.7461 3071395 PK04_107284 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O09 compound treatment 1.256168E7 452000.0 0.25 1.323328E7 370000.0 0.21 0.3269 0.9952 3189696 PK04_107285 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O10 compound treatment 1.281804E7 708000.0 0.4 1.350688E7 644000.0 0.36 0.5377 0.9989 3189697 PK04_107286 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O11 mock treatment 1.259416E7 484000.0 0.27 1.3112E7 249000.0 0.14 0.2916 0.9525 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O12 mock treatment 1.309128E7 982000.0 0.55 1.361764E7 755000.0 0.42 0.6903 0.9917 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O13 compound treatment 1.191948E7 -190000.0 -0.11 1.762288E7 4760000.0 2.68 1.8191 0.6784 3071396 PK04_107287 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](C)NC2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O14 compound treatment 1.348208E7 1370000.0 0.77 1.38462E7 983000.0 0.55 0.9365 0.9868 3187592 PK04_107288 CC(C)[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O15 compound treatment 1.2146E7 36200.0 0.02 1.298228E7 119000.0 0.07 0.0619 0.8817 3187593 PK04_107289 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](Cc5ccccc5)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O16 compound treatment 1.353888E7 1430000.0 0.8 1.316392E7 301000.0 0.17 0.6874 0.8379 3071397 PK04_107290 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O17 compound treatment 1.229808E7 188000.0 0.11 1.26152E7 -248000.0 -0.14 -0.0238 -0.1359 3187594 PK04_107291 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O18 compound treatment 1.241252E7 303000.0 0.17 1.235232E7 -511000.0 -0.29 -0.083 -0.2484 3071398 PK04_107292 CC(C)[Si](O[C@H](C)c1cn(Cc2ccccc2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O19 compound treatment 1.175984E7 -350000.0 -0.2 1.29214E7 58500.0 0.03 -0.1157 -0.5804 3187595 PK04_107293 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](NC2=O)C(C)C)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O20 compound treatment 1.175804E7 -352000.0 -0.2 1.215512E7 -708000.0 -0.4 -0.4214 -0.9476 3071399 PK04_107294 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O21 compound treatment 1.116516E7 -945000.0 -0.53 1.181296E7 -1050000.0 -0.59 -0.7931 -0.9986 3187594 PK04_107295 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O22 compound treatment 1.127908E7 -831000.0 -0.47 1.17852E7 -1080000.0 -0.61 -0.7589 -0.9916 3187596 PK04_107296 CC(C)[Si](O[C@H](C)c1cn(Cc2cccc(Cl)c2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O23 compound treatment 1.036452E7 -1750000.0 -0.98 1.18824E7 -980000.0 -0.55 -1.0834 -0.9631 3187597 PK04_107297 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](NC2=O)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 O24 compound treatment 8727280.0 -3380000.0 -1.9 1.023388E7 -2630000.0 -1.48 -2.3898 -0.9924 3071400 PK04_107298 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](C)c2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P01 compound treatment 9555400.0 -2550000.0 -1.43 1.01674E7 -2700000.0 -1.52 -2.0874 -0.9996 3187598 PK04_107299 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P02 compound treatment 1.120584E7 -904000.0 -0.51 1.1087E7 -1780000.0 -1.0 -1.0659 -0.9507 3071401 PK04_107300 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P03 compound treatment 1.158264E7 -527000.0 -0.3 1.17412E7 -1120000.0 -0.63 -0.6558 -0.9404 3187599 PK04_107301 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P04 compound treatment 1.189836E7 -211000.0 -0.12 1.017744E7 -2690000.0 -1.51 -1.1529 -0.7603 3187600 PK04_107302 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P05 compound treatment 1.201732E7 -92400.0 -0.05 1.193808E7 -925000.0 -0.52 -0.4048 -0.7738 3071402 PK04_107303 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P06 compound treatment 1.226992E7 160000.0 0.09 1.266208E7 -201000.0 -0.11 -0.0163 -0.1129 3187601 PK04_107304 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P07 compound treatment 1.24906E7 381000.0 0.21 1.248836E7 -374000.0 -0.21 0.0022 0.0073 3187602 PK04_107305 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P08 compound treatment 1.194068E7 -169000.0 -0.09 1.162084E7 -1240000.0 -0.7 -0.5615 -0.7958 3071403 PK04_107306 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P09 compound treatment 1.222E7 110000.0 0.06 1.269208E7 -171000.0 -0.1 -0.0242 -0.2115 3187603 PK04_107307 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P10 compound treatment 1.180808E7 -302000.0 -0.17 1.264208E7 -221000.0 -0.12 -0.2077 -0.9884 3187604 PK04_107308 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P11 mock treatment 1.291268E7 803000.0 0.45 1.329936E7 437000.0 0.25 0.4926 0.9592 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P12 mock treatment 1.216472E7 55000.0 0.03 1.28688E7 5950.0 0.0 0.0242 0.7792 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P13 compound treatment 1.127756E7 -832000.0 -0.47 1.336676E7 504000.0 0.28 -0.1299 -0.2377 3071404 PK04_107309 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P14 compound treatment 1.149512E7 -615000.0 -0.35 1.164872E7 -1210000.0 -0.68 -0.7274 -0.95 3187605 PK04_107310 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P15 compound treatment 1.195092E7 -159000.0 -0.09 1.290844E7 45600.0 0.03 -0.0449 -0.4841 3187606 PK04_107311 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P16 compound treatment 1.157328E7 -536000.0 -0.3 1.1994E7 -869000.0 -0.49 -0.5589 -0.9729 3071405 PK04_107312 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P17 compound treatment 1.192432E7 -185000.0 -0.1 1.203656E7 -826000.0 -0.47 -0.4025 -0.8445 3187607 PK04_107313 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P18 compound treatment 1.063488E7 -1470000.0 -0.83 1.201372E7 -849000.0 -0.48 -0.9238 -0.9659 3187608 PK04_107314 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P19 compound treatment 1.1993E7 -117000.0 -0.07 1.144916E7 -1410000.0 -0.8 -0.6091 -0.7628 3187728 PK04_107315 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P20 compound treatment 1.02754E7 -1830000.0 -1.03 1.105904E7 -1800000.0 -1.02 -1.4465 -1.0 3071452 PK04_107316 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P21 compound treatment 1.195204E7 -158000.0 -0.09 1.16492E7 -1210000.0 -0.68 -0.5457 -0.7922 3187729 PK04_107317 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P22 compound treatment 1.024372E7 -1870000.0 -1.05 1.125144E7 -1610000.0 -0.91 -1.3825 -0.9974 3187730 PK04_107318 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P23 compound treatment 1.042308E7 -1690000.0 -0.95 1.081256E7 -2050000.0 -1.15 -1.486 -0.9952 3071453 PK04_107319 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2107 P24 compound treatment 6304720.0 -5810000.0 -3.26 8887600.0 -3980000.0 -2.24 -3.8879 -0.9831 3187731 PK04_107320 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A01 compound treatment 9127640.0 -3990000.0 -2.24 9365120.0 -2210000.0 -1.24 8827120.0 -3975345.625 -2.33422301021895 -3.3578 -0.9691 3187732 PK04_108001 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A02 compound treatment 1.0084E7 -3030000.0 -1.7 9566240.0 -2010000.0 -1.13 1.035956E7 -2442905.625 -1.43441276798877 -2.4628 -0.9868 3071454 PK04_108002 CCC1=C2CN(Cc3ccccc3Br)[C@@H]([C@@H](O)Cc4ccccc4)C2C=CCC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A03 compound treatment 1.10656E7 -2050000.0 -1.15 1.047456E7 -1100000.0 -0.62 1.095604E7 -1846425.625 -1.0841747075848 -1.647 -0.9704 3187733 PK04_108003 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A04 compound treatment 1.143176E7 -1680000.0 -0.94 1.045764E7 -1120000.0 -0.63 1.119208E7 -1610385.625 -0.945577953665558 -1.4538 -0.9845 3071455 PK04_108004 CCC1=C2CN(Cc3ccccc3)[C@H](C2C=CCC1)C(=O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A05 compound treatment 1.135736E7 -1760000.0 -0.99 1.048332E7 -1090000.0 -0.61 1.139456E7 -1407905.625 -0.826686788042912 -1.4009 -0.9826 3187734 PK04_108005 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A06 compound treatment 1.169932E7 -1410000.0 -0.79 1.102732E7 -546000.0 -0.31 1.154144E7 -1261025.625 -0.740442544627987 -1.0634 -0.9423 3071456 PK04_108006 C/C=C\[C@@H](NCc1ccccc1Br)[C@@H](O)Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A07 compound treatment 1.142844E7 -1690000.0 -0.95 1.103636E7 -537000.0 -0.3 1.226776E7 -534705.625 -0.313965700420955 -0.9021 -0.8658 3187735 PK04_108007 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A08 compound treatment 1.213064E7 -983000.0 -0.55 1.154852E7 -24400.0 -0.01 1.210368E7 -698785.625 -0.410309351425319 -0.5636 -0.8191 3071457 PK04_108008 CC(=CCN[C@H](CO)c1ccccc1)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A09 compound treatment 1.030804E7 -2810000.0 -1.58 1.183104E7 258000.0 0.15 1.139536E7 -1407105.625 -0.826217048155032 -1.3029 -0.7298 3187736 PK04_108009 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A10 compound treatment 1.225316E7 -860000.0 -0.48 1.14154E7 -157000.0 -0.09 1.206472E7 -737745.625 -0.433185683965117 -0.5803 -0.8859 3071458 PK04_108010 CC(=CCN(CC#C)[C@H](CO)c1ccccc1)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A11 compound treatment 1.1431E7 -1680000.0 -0.95 1.105652E7 -516000.0 -0.29 1.152984E7 -1272625.625 -0.747253773002259 -1.1449 -0.9238 3071459 PK04_108011 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A12 compound treatment 1.026132E7 -2850000.0 -1.6 1.049084E7 -1080000.0 -0.61 1.119144E7 -1611025.625 -0.945953745575862 -1.8227 -0.9311 3187737 PK04_108012 CC(=CCN(CC#Cc1ccccc1)[C@H](CO)c2ccccc2)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A13 mock treatment 1.207184E7 -1040000.0 -0.59 1.147972E7 -93200.0 -0.05 1.224296E7 -559505.625 -0.328527636945262 -0.5578 -0.8287 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A14 mock treatment 1.183628E7 -1280000.0 -0.72 1.149852E7 -74400.0 -0.04 1.21374E7 -665065.625 -0.390509815151141 -0.6638 -0.8116 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A15 compound treatment 1.135952E7 -1750000.0 -0.99 1.1217E7 -356000.0 -0.2 1.124164E7 -1560825.625 -0.916477567611338 -1.2136 -0.8921 3187738 PK04_108013 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A16 compound treatment 1.179932E7 -1310000.0 -0.74 1.11838E7 -389000.0 -0.22 1.20974E7 -705065.625 -0.413996809545184 -0.7917 -0.9056 3071460 PK04_108014 O=C1OC[C@@H](c2ccccc2)n3cc(/C=C/c4ccccc4)cc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A17 compound treatment 1.147104E7 -1640000.0 -0.92 1.041088E7 -1160000.0 -0.65 1.12284E7 -1574065.625 -0.924251762755767 -1.4439 -0.9886 3187739 PK04_108015 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A18 compound treatment 1.178576E7 -1330000.0 -0.75 1.038884E7 -1180000.0 -0.67 1.191712E7 -885345.625 -0.519852693279136 -1.1155 -0.9896 3071461 PK04_108016 CC(=C)C/1CN([C@H](CO)c2ccccc2)C(=O)\C1=C/c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A19 compound treatment 1.162272E7 -1490000.0 -0.84 1.03704E7 -1200000.0 -0.68 1.153768E7 -1264785.625 -0.742650322101027 -1.303 -0.9962 3187740 PK04_108017 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A20 compound treatment 1.143584E7 -1680000.0 -0.94 1.019384E7 -1380000.0 -0.78 1.181628E7 -986185.625 -0.579063406146518 -1.3266 -0.9817 3071462 PK04_108018 OCC(/C=C/c1ccccc1)N(CC#C)C(C(=O)O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A21 compound treatment 1.088288E7 -2230000.0 -1.25 8512240.0 -3060000.0 -1.72 1.06756E7 -2126865.625 -1.24884202528144 -2.4391 -0.9877 3187741 PK04_108019 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A22 compound treatment 1.079344E7 -2320000.0 -1.3 1.0162E7 -1410000.0 -0.79 1.05906E7 -2211865.625 -1.29875188836878 -1.9607 -0.9784 3071463 PK04_108020 C/C=C/CN([C@H](CO[Si](C)(C)C(C)(C)C)c1ccccc1)C(=O)C#Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A23 compound treatment 1.023432E7 -2880000.0 -1.62 8756120.0 -2820000.0 -1.59 1.012756E7 -2674905.625 -1.57063733547422 -2.7559 -0.9999 3187742 PK04_108021 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 A24 compound treatment 8995040.0 -4120000.0 -2.31 1.057928E7 -994000.0 -0.56 8766200.0 -4036265.625 -2.36999370268108 -3.0268 -0.9012 3071464 PK04_108022 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B01 compound treatment 1.217132E7 -942000.0 -0.53 1.074008E7 -833000.0 -0.47 1.151636E7 -1286105.625 -0.755168890113052 -1.0122 -0.9785 2133065 PK04_108023 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(C3CCCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B02 compound treatment 1.135268E7 -1760000.0 -0.99 1.052396E7 -1050000.0 -0.59 1.098152E7 -1820945.625 -1.0692134921558 -1.5292 -0.973 3071465 PK04_108024 CCCCNC(=O)c1ccc(C#CC(C)(C)C)c(OC(=O)C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B03 compound treatment 1.26832E7 -430000.0 -0.24 1.139396E7 -179000.0 -0.1 1.22954E7 -507065.625 -0.297736187294672 -0.3696 -0.9321 2133224 PK04_108025 CCCCC(=O)N(Cc1ccccc1F)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B04 compound treatment 1.307924E7 -34300.0 -0.02 1.221576E7 643000.0 0.36 1.210396E7 -698505.625 -0.410144942464561 -0.039 -0.0712 1952196 PK04_108026 CCCCNC(=O)c1ccc(C#C[Si](C)(C)C)c(OC(=O)C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B05 compound treatment 1.242844E7 -685000.0 -0.38 1.0984E7 -589000.0 -0.33 1.20406E7 -761865.625 -0.447348341584725 -0.6718 -0.9926 2133510 PK04_108027 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCc3cccc(F)c3)C(=O)CCC4CCCC4)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B06 compound treatment 1.282592E7 -288000.0 -0.16 1.130936E7 -264000.0 -0.15 1.274236E7 -60105.625 -0.0352925119356362 -0.1993 -0.8971 3071510 PK04_108028 CCCCNC(=O)c1ccc(C#C[Si](C(C)C)(C(C)C)C(C)C)c(OC(=O)C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B07 compound treatment 1.296692E7 -147000.0 -0.08 1.163196E7 59100.0 0.03 1.269836E7 -104105.625 -0.0611282057690834 -0.0636 -0.5902 2128988 PK04_108029 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H]3O[C@@H]32)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B08 compound treatment 1.328472E7 171000.0 0.1 1.117344E7 -399000.0 -0.22 1.263004E7 -172425.625 -0.101243992194109 -0.1328 -0.5016 3187870 PK04_108030 COC(=O)C[C@H]1O[C@@H](CCc2ccccc2)[C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B09 compound treatment 1.34246E7 311000.0 0.17 1.2629E7 1060000.0 0.59 1.279612E7 -6345.625 -0.00372599147004247 0.442 0.7132 3187871 PK04_108031 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)N(Cc3ccco3)C(=O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B10 compound treatment 1.338616E7 273000.0 0.15 1.21572E7 584000.0 0.33 1.328424E7 481774.375 0.282885801120463 0.4416 0.9599 3071511 PK04_108032 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(I)cc52 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B11 compound treatment 1.331476E7 201000.0 0.11 1.173644E7 164000.0 0.09 1.324168E7 439214.375 0.257895639085202 0.2673 0.9023 2129008 PK04_108033 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)NCc3ccc(F)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B12 compound treatment 1.34652E7 352000.0 0.2 1.23188E7 746000.0 0.42 1.305864E7 256174.375 0.150419152738061 0.4433 0.9088 3187872 PK04_108034 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc52 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B13 mock treatment 1.363744E7 524000.0 0.29 1.06596E7 -913000.0 -0.51 1.360724E7 804774.375 0.47254328085236 0.1459 0.1925 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B14 mock treatment 1.31618E7 48200.0 0.03 1.236588E7 793000.0 0.45 1.320868E7 406214.375 0.238518868710116 0.4111 0.8111 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B15 compound treatment 1.281404E7 -300000.0 -0.17 1.047212E7 -1100000.0 -0.62 1.163268E7 -1169785.625 -0.686868710415175 -0.8514 -0.9056 3187873 PK04_108035 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CCC\C=C\CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B16 compound treatment 1.3427E7 313000.0 0.18 1.180052E7 228000.0 0.13 1.284976E7 47294.375 0.0277700680123691 0.1917 0.8731 3414061 PK04_108036 COC(=O)C[C@@H]1C[C@H](C)[C@]2(O1)C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B17 compound treatment 1.230496E7 -809000.0 -0.45 1.062216E7 -951000.0 -0.54 1.156348E7 -1238985.625 -0.727501210716869 -0.9912 -0.9805 3187874 PK04_108037 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CCC\C=C\CNC(=O)[C@@H](Cc5ccccc5)NC(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B18 compound treatment 1.366444E7 551000.0 0.31 1.137472E7 -198000.0 -0.11 1.265268E7 -149785.625 -0.0879503533670804 0.0635 0.1864 3071513 PK04_108038 CC(C)[Si](OCC[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)O)C(=O)N(Cc3ccccc3)c4ccccc42)(C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B19 compound treatment 1.31454E7 31800.0 0.02 1.1302E7 -271000.0 -0.15 1.247392E7 -328545.625 -0.192913731314058 -0.1891 -0.7669 3187875 PK04_108039 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CCC\C=C\CNC(=O)[C@@H]5CCCN5C(=O)CNC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B20 compound treatment 1.29544E7 -159000.0 -0.09 1.141392E7 -159000.0 -0.09 1.271072E7 -91745.625 -0.0538707245013241 -0.1344 -0.9774 3071514 PK04_108040 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccccc53 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B21 compound treatment 9764480.0 -3350000.0 -1.88 9523160.0 -2050000.0 -1.15 9606280.0 -3196185.625 -1.87671984641739 -2.8357 -0.9789 3187876 PK04_108041 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/CC\C=C\CNC(=O)[C@@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B22 compound treatment 1.238096E7 -733000.0 -0.41 1.101336E7 -560000.0 -0.31 1.19404E7 -862065.625 -0.506183262541803 -0.7117 -0.9824 3071515 PK04_108042 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(C)cc3)C(=O)N(C)c4ccccc42 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B23 compound treatment 1.125672E7 -1860000.0 -1.04 1.01396E7 -1430000.0 -0.81 1.028784E7 -2514625.625 -1.47652494893729 -1.9204 -0.9701 3187877 PK04_108043 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC(=O)[C@@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 B24 compound treatment 1.098856E7 -2120000.0 -1.19 9741880.0 -1830000.0 -1.03 1.028964E7 -2512825.625 -1.47546803418956 -2.136 -0.9891 3071516 PK04_108044 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(C)c4ccccc42 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C01 compound treatment 1.136628E7 -1750000.0 -0.98 1.08158E7 -757000.0 -0.43 1.057056E7 -2231905.625 -1.3105188725602 -1.5693 -0.9276 3187878 PK04_108045 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C02 compound treatment 1.25456E7 -568000.0 -0.32 1.137748E7 -195000.0 -0.11 1.195404E7 -848425.625 -0.498174197453434 -0.5353 -0.8897 3071464 PK04_108046 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C03 compound treatment 1.214528E7 -968000.0 -0.54 1.114372E7 -429000.0 -0.24 1.215392E7 -648545.625 -0.380809686466402 -0.6733 -0.953 3187879 PK04_108047 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C04 compound treatment 1.273508E7 -378000.0 -0.21 1.126832E7 -305000.0 -0.17 1.228396E7 -518505.625 -0.304453467691368 -0.3975 -0.9719 3071517 PK04_108048 CC(=C)C1C(=C)CN([C@H](CO)c2ccccc2)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C05 compound treatment 1.2848E7 -266000.0 -0.15 1.175256E7 180000.0 0.1 1.267356E7 -128905.625 -0.07569014229339 -0.0714 -0.3654 3071518 PK04_108049 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C06 compound treatment 1.37298E7 616000.0 0.35 1.105576E7 -517000.0 -0.29 1.299048E7 188014.375 0.110397314290612 0.0955 0.2052 3187880 PK04_108050 CC(C)(C)OC(=O)N(CC#C)[C@H](CO)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C07 compound treatment 1.343224E7 319000.0 0.18 1.168736E7 114000.0 0.06 1.350036E7 697894.375 0.409786031831477 0.3771 0.8348 3187881 PK04_108051 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C08 compound treatment 1.313512E7 21600.0 0.01 1.01908E7 -1380000.0 -0.78 1.264108E7 -161385.625 -0.0947615817413528 -0.4969 -0.6339 3071519 PK04_108052 CC(=CCN([C@H](CO)c1ccccc1)C(=O)C#Cc2ccccc2)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C09 compound treatment 1.34546E7 341000.0 0.19 1.07908E7 -782000.0 -0.44 1.25986E7 -203865.625 -0.119704769787826 -0.2127 -0.4298 3187882 PK04_108053 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C10 compound treatment 1.3075E7 -38600.0 -0.02 1.198376E7 411000.0 0.23 1.262248E7 -179985.625 -0.105683034134583 0.06 0.2352 3071520 PK04_108054 OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C11 mock treatment 1.380536E7 692000.0 0.39 1.229084E7 718000.0 0.4 1.306972E7 267254.375 0.156925050185211 0.5483 0.9417 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C12 mock treatment 1.344796E7 334000.0 0.19 1.220988E7 637000.0 0.36 1.317064E7 368174.375 0.216182737041381 0.4403 0.9594 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C13 compound treatment 1.449224E7 1380000.0 0.77 1.290504E7 1330000.0 0.75 1.31818E7 379334.375 0.222735608477319 1.0086 0.9163 3187883 PK04_108055 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C14 compound treatment 1.364352E7 530000.0 0.3 1.234168E7 769000.0 0.43 1.404688E7 1244414.375 0.730688836237286 0.8436 0.9374 3071521 PK04_108056 CC(C)(C)[Si](C)(C)OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C15 mock treatment 1.325824E7 145000.0 0.08 1.229708E7 724000.0 0.41 1.281252E7 10054.375 0.00590367623151513 0.2857 0.6872 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C16 mock treatment 1.316348E7 49900.0 0.03 1.16392E7 66300.0 0.04 1.280516E7 2694.375 0.00158206926301123 0.0387 0.8275 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C17 compound treatment 1.266752E7 -446000.0 -0.25 1.15274E7 -45500.0 -0.03 1.268596E7 -116505.625 -0.0684091740312367 -0.1989 -0.7623 3188001 PK04_108057 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C18 compound treatment 1.30764E7 -37200.0 -0.02 1.232808E7 755000.0 0.43 1.302296E7 220494.375 0.129468753738575 0.3081 0.6926 3071522 PK04_108058 O=C1OC[C@H](N2CC(=CC21)/C=C/c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C19 compound treatment 1.272712E7 -386000.0 -0.22 1.129916E7 -274000.0 -0.15 1.232064E7 -481825.625 -0.282915893832031 -0.3776 -0.9721 3188002 PK04_108059 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C20 compound treatment 1.278688E7 -327000.0 -0.18 1.091108E7 -662000.0 -0.37 1.23546E7 -447865.625 -0.262975435591488 -0.4728 -0.962 3071523 PK04_108060 OCC(/C=C/c1ccccc1)N(CC#C)Cc2ccccc2Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C21 compound treatment 1.217856E7 -935000.0 -0.53 1.087148E7 -701000.0 -0.39 1.143428E7 -1368185.625 -0.803364202609628 -0.995 -0.9587 3188003 PK04_108061 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C22 compound treatment 1.229688E7 -817000.0 -0.46 1.065212E7 -921000.0 -0.52 1.193732E7 -865145.625 -0.507991761110144 -0.8574 -0.9986 3071524 PK04_108062 OCC1C=C(CN1Cc2ccccc2Br)/C=C/c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C23 compound treatment 1.178448E7 -1330000.0 -0.75 1.091456E7 -658000.0 -0.37 1.095424E7 -1848225.625 -1.08523162233254 -1.2715 -0.9292 3188004 PK04_108063 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 C24 compound treatment 1.066896E7 -2440000.0 -1.37 1.0376E7 -1200000.0 -0.67 1.06626E7 -2139865.625 -1.2564752984595 -1.9072 -0.9635 3071525 PK04_108064 CCOC(=O)C1OC[C@H](N1CC#C)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D01 compound treatment 8080920.0 -5030000.0 -2.83 7452120.0 -4120000.0 -2.32 7691040.0 -5111425.625 -3.00130062499856 -4.704 -0.9944 3188005 PK04_108065 CC(C)C[C@@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D02 compound treatment 1.216444E7 -949000.0 -0.53 1.158464E7 11800.0 0.01 1.19132E7 -889265.625 -0.522154418729752 -0.6054 -0.8113 3414062 PK04_108066 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccccc3)C(=O)N(C)c4ccccc42 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D03 compound treatment 9666240.0 -3450000.0 -1.94 9384400.0 -2190000.0 -1.23 9930280.0 -2872185.625 -1.68647519182564 -2.8028 -0.9842 3188006 PK04_108067 CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D04 compound treatment 1.381248E7 699000.0 0.39 1.131988E7 -253000.0 -0.14 1.271676E7 -85705.625 -0.0503241883478236 0.1154 0.2743 3071527 PK04_108068 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D05 compound treatment 1.038648E7 -2730000.0 -1.53 1.038868E7 -1180000.0 -0.67 1.03942E7 -2408265.625 -1.41407303084353 -2.0856 -0.9529 3188007 PK04_108069 CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D06 compound treatment 1.347244E7 359000.0 0.2 1.146036E7 -113000.0 -0.06 1.331176E7 509294.375 0.299044853263565 0.2525 0.6895 3071528 PK04_108070 CCOC(=O)[C@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@@H]2O[Si](C)(C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D07 compound treatment 1.167712E7 -1440000.0 -0.81 9683200.0 -1890000.0 -1.06 1.20676E7 -734865.625 -0.431494620368746 -1.3291 -0.9473 3188008 PK04_108071 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CC\C=C\CNC(=O)[C@@H]5CCCN5C(=O)[C@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D08 compound treatment 1.294132E7 -172000.0 -0.1 1.142652E7 -146000.0 -0.08 1.391884E7 1116374.375 0.655506967181954 0.275 0.4119 3071529 PK04_108072 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D09 compound treatment 1.29232E7 -190000.0 -0.11 1.09924E7 -580000.0 -0.33 1.271056E7 -91905.625 -0.0539646724789003 -0.2815 -0.809 3188009 PK04_108073 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)CNC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D10 compound treatment 1.29048E7 -209000.0 -0.12 1.224004E7 667000.0 0.38 1.36564E7 853934.375 0.501408796962639 0.4386 0.6882 3071530 PK04_108074 CCOC(=O)[C@H]1C[C@H]2O[C@]32C[C@H]1C(=O)N4CCCC4[C@@H]3O[Si](C)(C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D11 mock treatment 1.330696E7 193000.0 0.11 1.21152E7 542000.0 0.31 1.372712E7 924654.375 0.542933803051307 0.5524 0.8737 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D12 mock treatment 1.363904E7 525000.0 0.3 1.162788E7 55000.0 0.03 1.34114E7 608934.375 0.357550956299126 0.3947 0.8495 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D13 compound treatment 1.407996E7 966000.0 0.54 1.35126E7 1940000.0 1.09 1.336184E7 559374.375 0.328450570244907 1.1334 0.8975 3188010 PK04_108075 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D14 compound treatment 1.362096E7 507000.0 0.29 1.233104E7 758000.0 0.43 1.509256E7 2290094.375 1.34468584368636 1.1873 0.8249 3071531 PK04_108076 CCOC(=O)[C@@H]1[C@@H]2CN(CCC2=C[C@@H]3[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]4CCCN4C(=O)[C@@H]13)S(=O)(=O)c5ccc(C)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D15 mock treatment 1.380272E7 689000.0 0.39 1.156024E7 -12600.0 -0.01 1.292224E7 119774.375 0.0703285018543749 0.26 0.6607 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D16 mock treatment 1.408412E7 971000.0 0.55 1.173684E7 164000.0 0.09 1.312992E7 327454.375 0.192272976748246 0.479 0.8183 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D17 compound treatment 1.227648E7 -837000.0 -0.47 1.024712E7 -1330000.0 -0.75 1.228068E7 -521785.625 -0.30637940123168 -0.8792 -0.9416 3071578 PK04_108077 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D18 compound treatment 1.292572E7 -188000.0 -0.11 1.062256E7 -950000.0 -0.53 1.17946E7 -1007865.625 -0.591793357108089 -0.7114 -0.8841 3071579 PK04_108078 O=C1C=C(C(=O)C2=C1CC(=CC2)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D19 compound treatment 1.12602E7 -1850000.0 -1.04 9221520.0 -2350000.0 -1.32 1.06484E7 -2154065.625 -1.26481318146939 -2.0954 -0.995 3071580 PK04_108079 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc6ccccc6)NC2=O)[C@@H]7O[C@]7(C)[C@H]4C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D20 compound treatment 1.252368E7 -590000.0 -0.33 1.048848E7 -1080000.0 -0.61 1.102792E7 -1774545.625 -1.04196857865871 -1.1453 -0.9146 3188011 PK04_108080 O=C1C=C(C(=O)c2ccc(cc12)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D21 compound treatment 1.308708E7 -26500.0 -0.01 1.081456E7 -758000.0 -0.43 1.202616E7 -776305.625 -0.455827146560975 -0.5182 -0.8296 3188012 PK04_108081 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D22 compound treatment 1.232864E7 -785000.0 -0.44 1.12926E7 -280000.0 -0.16 1.187688E7 -925585.625 -0.543480609639543 -0.6594 -0.9192 3071581 PK04_108082 O=C1C2CC=C(CC2C(=O)c3ccccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D23 compound treatment 1.198376E7 -1130000.0 -0.63 1.08858E7 -687000.0 -0.39 1.13096E7 -1492865.625 -0.87657316413586 -1.0958 -0.9535 3188013 PK04_108083 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 D24 compound treatment 1.195672E7 -1160000.0 -0.65 1.067008E7 -903000.0 -0.51 1.1774E7 -1028465.625 -0.603889159221021 -1.0172 -0.995 3071582 PK04_108084 O=C1c2ccccc2C(=O)c3cc(ccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E01 mock treatment 1.192584E7 -1190000.0 -0.67 1.092356E7 -649000.0 -0.37 1.147876E7 -1323705.625 -0.777246664843452 -1.0449 -0.9608 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E02 mock treatment 1.289444E7 -219000.0 -0.12 1.199364E7 421000.0 0.24 1.265556E7 -146905.625 -0.0862592897707093 0.0159 0.0567 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E03 compound treatment 1.087864E7 -2230000.0 -1.26 1.014844E7 -1420000.0 -0.8 1.145284E7 -1349625.625 -0.792466237210792 -1.6452 -0.9751 3188014 PK04_108085 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E04 compound treatment 1.1873E7 -1240000.0 -0.7 1.037044E7 -1200000.0 -0.68 1.1806E7 -996465.625 -0.585099563705787 -1.1309 -0.9972 3071583 PK04_108086 C/C=C/CN([C@H](CO)c1ccccc1)C(=O)C#Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E05 compound treatment 1.1744E7 -1370000.0 -0.77 1.111964E7 -453000.0 -0.26 1.300392E7 201454.375 0.118288944407011 -0.5231 -0.6387 3188015 PK04_108087 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E06 compound treatment 1.357552E7 462000.0 0.26 1.111056E7 -462000.0 -0.26 1.324944E7 446974.375 0.262452115997646 0.1511 0.3346 3071584 PK04_108088 OCC(NCC#C)/C=C/c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E07 compound treatment 1.385876E7 745000.0 0.42 1.164272E7 69800.0 0.04 1.313304E7 330574.375 0.194104962310981 0.3764 0.8129 3188129 PK04_108089 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E08 compound treatment 1.18454E7 -1270000.0 -0.71 1.136168E7 -211000.0 -0.12 1.333408E7 531614.375 0.312150596135441 -0.2997 -0.3809 3071585 PK04_108090 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E09 mock treatment 1.343832E7 325000.0 0.18 1.21178E7 545000.0 0.31 1.322604E7 423574.375 0.248712224277131 0.426 0.9793 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E10 mock treatment 1.369788E7 584000.0 0.33 1.22848E7 712000.0 0.4 1.305792E7 255454.375 0.149996386838968 0.5075 0.941 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E11 compound treatment 1.463348E7 1520000.0 0.85 1.177624E7 203000.0 0.11 1.34056E7 603134.375 0.35414534211199 0.7635 0.8198 3071586 PK04_108091 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E12 compound treatment 1.312576E7 12200.0 0.01 1.170896E7 136000.0 0.08 1.31616E7 359134.375 0.210874676308328 0.1699 0.7571 3188130 PK04_108092 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E13 compound treatment 1.378248E7 669000.0 0.38 1.25496E7 977000.0 0.55 1.37384E7 935934.375 0.549557135470427 0.8516 0.9864 3188131 PK04_108093 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E14 compound treatment 1.5304E7 2190000.0 1.23 1.17438E7 171000.0 0.1 1.420316E7 1400694.375 0.822452523334811 1.2407 0.8366 3071587 PK04_108094 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E15 compound treatment 1.35268E7 413000.0 0.23 1.141992E7 -153000.0 -0.09 1.135608E7 -1446385.625 -0.849281276649982 -0.406 -0.459 3188132 PK04_108095 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E16 compound treatment 1.3839E7 725000.0 0.41 1.126292E7 -310000.0 -0.17 1.2458E7 -344465.625 -0.202261555082887 0.0177 0.0364 3071588 PK04_108096 BrC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E17 mock treatment 1.302632E7 -87200.0 -0.05 1.0711E7 -862000.0 -0.49 1.23732E7 -429265.625 -0.252053983198258 -0.4539 -0.8269 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E18 mock treatment 1.35486E7 435000.0 0.24 1.191284E7 340000.0 0.19 1.247168E7 -330785.625 -0.194229003000125 0.1394 0.3808 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E19 compound treatment 1.310032E7 -13200.0 -0.01 1.013576E7 -1440000.0 -0.81 1.178428E7 -1018185.625 -0.597853001661752 -0.8165 -0.8117 3188133 PK04_108097 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E20 compound treatment 1.292508E7 -188000.0 -0.11 1.143616E7 -137000.0 -0.08 1.175988E7 -1042585.625 -0.612180068242118 -0.459 -0.7332 3071589 PK04_108098 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E21 compound treatment 1.249932E7 -614000.0 -0.35 1.031056E7 -1260000.0 -0.71 1.125564E7 -1546825.625 -0.908257119573423 -1.1338 -0.942 3188134 PK04_108099 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E22 compound treatment 1.180076E7 -1310000.0 -0.74 1.053572E7 -1040000.0 -0.58 1.155108E7 -1251385.625 -0.734782178979022 -1.187 -0.9946 3071590 PK04_108100 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E23 compound treatment 1.169568E7 -1420000.0 -0.8 1.100812E7 -565000.0 -0.32 1.160948E7 -1192985.625 -0.70049116716372 -1.0478 -0.9463 3188135 PK04_108101 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 E24 compound treatment 1.050412E7 -2610000.0 -1.47 9839240.0 -1730000.0 -0.98 1.066484E7 -2137625.625 -1.25516002677344 -2.1343 -0.987 3071591 PK04_108102 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F01 mock treatment 1.215148E7 -962000.0 -0.54 1.109656E7 -476000.0 -0.27 1.139136E7 -1411105.625 -0.828565747594436 -0.9452 -0.9222 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F02 mock treatment 1.179248E7 -1320000.0 -0.74 1.169716E7 124000.0 0.07 1.225028E7 -552185.625 -0.324229516971152 -0.5752 -0.7077 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F03 compound treatment 1.268564E7 -428000.0 -0.24 1.151648E7 -56400.0 -0.03 1.258664E7 -215825.625 -0.126727381111645 -0.2303 -0.8417 3188136 PK04_108103 CC(C)C[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F04 compound treatment 1.246968E7 -644000.0 -0.36 1.112668E7 -446000.0 -0.25 1.250716E7 -295305.625 -0.173396038972609 -0.4539 -0.9592 3071592 PK04_108104 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F05 compound treatment 1.14414E7 -1670000.0 -0.94 1.033088E7 -1240000.0 -0.7 1.091948E7 -1882985.625 -1.10564182046096 -1.5842 -0.9838 3188137 PK04_108105 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](C)NC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F06 compound treatment 1.421496E7 1100000.0 0.62 1.151056E7 -62300.0 -0.04 1.29138E7 111334.375 0.0653727460372318 0.3747 0.6013 3071592 PK04_108106 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F07 compound treatment 1.36998E7 586000.0 0.33 1.231304E7 740000.0 0.42 1.292112E7 118654.375 0.0696708660113417 0.4709 0.8792 3071593 PK04_108107 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F08 compound treatment 1.356712E7 454000.0 0.25 9954800.0 -1620000.0 -0.91 1.297116E7 168694.375 0.0990530959982894 -0.3216 -0.3382 3188138 PK04_108108 Cc1ccc(cc1)S(=O)(=O)N(CCC=C)CC#C[C@H]2Oc3ccccc3S(=O)(=O)N4CCC[C@@H]24 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F09 mock treatment 1.404548E7 932000.0 0.52 1.17304E7 158000.0 0.09 1.274132E7 -61145.625 -0.0359031737898813 0.3327 0.6252 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F10 mock treatment 1.6564E7 3450000.0 1.94 1.182988E7 257000.0 0.14 1.359176E7 789294.375 0.463453814021865 1.47 0.7358 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F11 compound treatment 1.416416E7 1050000.0 0.59 1.169284E7 120000.0 0.07 1.634288E7 3540414.375 2.07884231445535 1.5799 0.7308 3188139 PK04_108109 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F12 compound treatment 1.398884E7 875000.0 0.49 1.252848E7 956000.0 0.54 1.314828E7 345814.375 0.203053507175111 0.7116 0.9407 3071594 PK04_108110 O=S1(=O)N2CCC[C@H]2[C@H](Oc3ccccc31)C#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F13 compound treatment 1.362628E7 513000.0 0.29 1.169236E7 119000.0 0.07 1.328308E7 480614.375 0.282204678283036 0.368 0.9003 3188140 PK04_108111 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](C)NC(=O)[C@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F14 compound treatment 1.399504E7 881000.0 0.5 1.238772E7 815000.0 0.46 1.3787E7 984534.375 0.578093833659189 0.8844 0.9952 3414064 PK04_108112 O=S1(=O)N2CCC[C@@H]2[C@@H](Oc3ccccc31)C#C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F15 compound treatment 1.355388E7 440000.0 0.25 1.153604E7 -36800.0 -0.02 1.360224E7 799774.375 0.469607406553105 0.402 0.7567 3071596 PK04_108113 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](C)NC(=O)[C@@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F16 compound treatment 1.448724E7 1370000.0 0.77 1.032476E7 -1250000.0 -0.7 1.27352E7 -67265.625 -0.0394966839321698 0.017 0.0163 3188141 PK04_108114 C=CC(=C)[C@H]1Oc2ccccc2S(=O)(=O)N3CCC[C@@H]13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F17 mock treatment 1.398404E7 870000.0 0.49 1.137164E7 -201000.0 -0.11 1.31364E7 333934.375 0.196077869840081 0.3301 0.6126 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F18 mock treatment 1.310308E7 -10500.0 -0.01 1.156692E7 -5950.0 0.0 1.311828E7 315814.375 0.185438261379579 0.1017 0.5482 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F19 compound treatment 1.16526E7 -1460000.0 -0.82 1.016624E7 -1410000.0 -0.79 1.096012E7 -1842345.625 -1.08177903415661 -1.5555 -0.9896 3188142 PK04_108115 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F20 compound treatment 1.230012E7 -813000.0 -0.46 1.031276E7 -1260000.0 -0.71 1.136016E7 -1442305.625 -0.846885603221789 -1.1623 -0.9722 3071597 PK04_108116 Cc1ccc(cc1)S(=O)(=O)NC/C=C\C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F21 compound treatment 1.256504E7 -549000.0 -0.31 1.054408E7 -1030000.0 -0.58 1.173872E7 -1063745.625 -0.624604688276567 -0.8728 -0.9636 3188143 PK04_108117 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC(=O)[C@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F22 compound treatment 1.275E7 -364000.0 -0.2 1.077044E7 -802000.0 -0.45 1.17552E7 -1047265.625 -0.614928046586221 -0.7337 -0.9289 3071598 PK04_108118 Cc1ccc(cc1)S(=O)(=O)NC/C=C/C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F23 compound treatment 1.276508E7 -348000.0 -0.2 1.05034E7 -1070000.0 -0.6 1.151288E7 -1289585.625 -0.757212258625333 -0.8978 -0.9096 3188144 PK04_108119 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC(=O)[C@@H](C)NC4=O)[C@@H]5O[C@@]51C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 F24 compound treatment 1.036324E7 -2750000.0 -1.54 9186640.0 -2390000.0 -1.34 9282840.0 -3519625.625 -2.06663568308762 -2.8606 -0.9834 3188260 PK04_108120 CC(=O)O[C@@H]([C@@H]1CCCN1S(=O)(=O)c2ccccc2[N+](=O)[O-])C(=C)C3=CCN(C3)S(=O)(=O)c4ccc(C)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G01 compound treatment 1.164808E7 -1470000.0 -0.82 1.105624E7 -517000.0 -0.29 1.148464E7 -1317825.625 -0.773794076667528 -1.0899 -0.9343 3071599 PK04_108121 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G02 compound treatment 1.192604E7 -1190000.0 -0.67 1.073168E7 -841000.0 -0.47 1.128864E7 -1513825.625 -0.888880349198338 -1.1717 -0.9699 3188261 PK04_108122 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3cccc(C)c3)C(=O)[C@@]42CO4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G03 mock treatment 1.312456E7 11000.0 0.01 1.123656E7 -336000.0 -0.19 1.223628E7 -566185.625 -0.332449965009067 -0.2977 -0.778 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G04 mock treatment 1.313884E7 25300.0 0.01 1.126644E7 -306000.0 -0.17 1.244248E7 -359985.625 -0.211374508907776 -0.2134 -0.7812 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G05 compound treatment 1.316952E7 56000.0 0.03 1.155884E7 -14000.0 -0.01 1.263444E7 -168025.625 -0.098660422810764 -0.0434 -0.4176 3188262 PK04_108123 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G06 compound treatment 1.317464E7 61100.0 0.03 1.075872E7 -814000.0 -0.46 1.296368E7 161214.375 0.0946610280466033 -0.1901 -0.4052 3071600 PK04_108124 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(OC)C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G07 compound treatment 1.24506E7 -663000.0 -0.37 1.135888E7 -214000.0 -0.12 1.172188E7 -1080585.625 -0.634492712916459 -0.6509 -0.8731 3189036 PK04_108125 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G08 compound treatment 1.354992E7 436000.0 0.25 1.17688E7 196000.0 0.11 1.337656E7 574094.375 0.337093784181914 0.3998 0.9274 3071601 PK04_108126 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G09 compound treatment 1.112496E7 -1990000.0 -1.12 1.133856E7 -234000.0 -0.13 1.334012E7 537654.375 0.315697132288941 -0.5388 -0.4612 3188263 PK04_108127 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G10 compound treatment 1.387932E7 766000.0 0.43 1.16518E7 78900.0 0.04 1.327856E7 476094.375 0.279550647916509 0.4354 0.8456 3071602 PK04_108128 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G11 compound treatment 1.3658E7 544000.0 0.31 1.21166E7 544000.0 0.31 1.364636E7 843894.375 0.495513561369734 0.6394 0.9719 3188264 PK04_108129 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G12 compound treatment 1.406048E7 947000.0 0.53 1.191144E7 339000.0 0.19 1.36582E7 855734.375 0.502465711710371 0.7072 0.9353 3071603 PK04_108130 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G13 compound treatment 1.40088E7 895000.0 0.5 1.228068E7 708000.0 0.4 1.318832E7 385854.375 0.226563988563548 0.6512 0.957 3188265 PK04_108131 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G14 compound treatment 1.383396E7 720000.0 0.4 1.409848E7 2530000.0 1.42 1.300416E7 201694.375 0.118429866373375 1.1228 0.7572 3071604 PK04_108132 CCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G15 compound treatment 1.469736E7 1580000.0 0.89 1.197376E7 401000.0 0.23 1.289228E7 89814.375 0.0527367430532367 0.6743 0.7336 3188266 PK04_108133 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G16 compound treatment 1.395396E7 840000.0 0.47 1.1413E7 -160000.0 -0.09 1.27054E7 -97065.625 -0.0569944947557318 0.1877 0.3878 3071651 PK04_108134 IC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G17 compound treatment 1.37162E7 603000.0 0.34 1.083408E7 -739000.0 -0.42 1.33026E7 500134.375 0.293666331547329 0.1249 0.2043 3188267 PK04_108135 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G18 compound treatment 1.3489E7 375000.0 0.21 1.140384E7 -169000.0 -0.1 1.268224E7 -120225.625 -0.0705934645098827 0.0261 0.1077 3071652 PK04_108136 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G19 mock treatment 1.367312E7 560000.0 0.31 1.166404E7 91200.0 0.05 1.19766E7 -825865.625 -0.484927532615194 -0.0689 -0.1187 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G20 mock treatment 1.379648E7 683000.0 0.38 1.098572E7 -587000.0 -0.33 1.31822E7 379734.375 0.22297047842126 0.1594 0.2881 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G21 compound treatment 1.319688E7 83300.0 0.05 1.137132E7 -202000.0 -0.11 1.24708E7 -331665.625 -0.194745716876794 -0.1509 -0.6556 3189164 PK04_108137 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G22 compound treatment 1.230932E7 -804000.0 -0.45 1.034812E7 -1220000.0 -0.69 1.171272E7 -1089745.625 -0.639871234632695 -1.0283 -0.9855 3071653 PK04_108138 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G23 compound treatment 1.163152E7 -1480000.0 -0.83 1.077236E7 -801000.0 -0.45 1.185312E7 -949345.625 -0.557431884309604 -1.0626 -0.9673 3189167 PK04_108139 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 G24 compound treatment 1.19384E7 -1180000.0 -0.66 1.060712E7 -966000.0 -0.54 1.190364E7 -898825.625 -0.527767810389928 -0.9997 -0.9948 3188268 PK04_108140 CCCCO[C@H]1C[C@H]2C(=C[C@]1(CO)C(=O)[C@@]32CO3)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H01 compound treatment 1.09194E7 -2190000.0 -1.23 1.061656E7 -956000.0 -0.54 1.119416E7 -1608305.625 -0.944356629957067 -1.5676 -0.9539 3188269 PK04_108141 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H02 compound treatment 1.215704E7 -957000.0 -0.54 1.131276E7 -260000.0 -0.15 1.210708E7 -695385.625 -0.408312956901826 -0.6305 -0.913 3071654 PK04_108142 [O-][N+](=O)c1ccccc1S(=O)(=O)N2CCC[C@@H]2[C@H]3OCC=C3C(=C)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H03 mock treatment 1.28922E7 -221000.0 -0.12 1.106464E7 -508000.0 -0.29 1.296548E7 163014.375 0.0957179427943353 -0.1817 -0.5568 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H04 mock treatment 1.307468E7 -38900.0 -0.02 1.124548E7 -327000.0 -0.18 1.299236E7 189894.375 0.111501203027132 -0.0546 -0.2523 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H05 compound treatment 1.316756E7 54000.0 0.03 1.090088E7 -672000.0 -0.38 1.27922E7 -10265.625 -0.00602771692065867 -0.2044 -0.5385 3188270 PK04_108143 CC(C)C[C@@H]1NC(=O)CNC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H06 compound treatment 1.389664E7 783000.0 0.44 1.178512E7 212000.0 0.12 1.29292E7 126734.375 0.0744152388789383 0.3659 0.7923 3071655 PK04_108144 CN1C(=O)C2CC=C(CC2C1=O)C3=CCO[C@@H]3[C@H]4CCCN4S(=O)(=O)c5ccccc5[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H07 compound treatment 1.262004E7 -494000.0 -0.28 1.174636E7 173000.0 0.1 1.267892E7 -123545.625 -0.0725428850445882 -0.1455 -0.4808 3188271 PK04_108145 CC(C)C[C@H]1NC(=O)CNC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H08 compound treatment 1.212236E7 -991000.0 -0.56 1.176904E7 196000.0 0.11 1.232296E7 -479505.625 -0.281553648157176 -0.4202 -0.6633 3071656 PK04_108146 CN1C(=C)C2CC3C4C(C5CO[C@H]([C@H]6CCCN6S(=O)(=O)c7ccccc7[N+](=O)[O-])C5=C3CC2C1=O)C(=O)N(C)C4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H09 compound treatment 1.085732E7 -2260000.0 -1.27 9344760.0 -2230000.0 -1.25 1.087368E7 -1928785.625 -1.13253442904214 -2.1097 -0.9988 3188272 PK04_108147 CC(C)C[C@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H10 compound treatment 1.39166E7 803000.0 0.45 1.208184E7 509000.0 0.29 1.394604E7 1143574.375 0.671478123369903 0.8135 0.948 3071529 PK04_108148 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H11 compound treatment 1.115228E7 -1960000.0 -1.1 9975280.0 -1600000.0 -0.9 1.158628E7 -1216185.625 -0.714113623912265 -1.5675 -0.9851 3188273 PK04_108149 CC(C)C[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC1=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H12 compound treatment 1.524408E7 2130000.0 1.2 1.08044E7 -768000.0 -0.43 1.47528E7 1950334.375 1.14518731330336 1.1023 0.6439 3071527 PK04_108150 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H13 compound treatment 1.175052E7 -1360000.0 -0.77 1.063148E7 -941000.0 -0.53 1.158508E7 -1217385.625 -0.714818233744086 -1.1607 -0.9888 3071658 PK04_108151 CC(C)C[C@H]1NC(=O)[C@@H](C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H14 compound treatment 1.417464E7 1060000.0 0.6 1.357684E7 2000000.0 1.13 1.285276E7 50294.375 0.0295315925919223 1.0124 0.7933 3188274 PK04_108152 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H15 compound treatment 1.32738E7 160000.0 0.09 1.140148E7 -171000.0 -0.1 1.322892E7 426454.375 0.250403287873502 0.1408 0.4976 3188275 PK04_108153 CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H16 compound treatment 1.351744E7 404000.0 0.23 1.186084E7 288000.0 0.16 1.293016E7 127694.375 0.0749789267443954 0.2679 0.9277 3071661 PK04_108154 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H17 compound treatment 1.143484E7 -1680000.0 -0.94 9965600.0 -1610000.0 -0.9 1.135284E7 -1449625.625 -0.851183723195899 -1.5582 -0.9991 3188391 PK04_108155 CC(C)C[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H18 compound treatment 1.3911E7 797000.0 0.45 1.126788E7 -305000.0 -0.17 1.3245E7 442534.375 0.259845059619907 0.3095 0.5673 3071664 PK04_108156 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)N(Cc6ccccc6)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H19 mock treatment 1.348E7 366000.0 0.21 1.133048E7 -242000.0 -0.14 1.295004E7 147574.375 0.0866519629582347 0.0901 0.3442 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H20 mock treatment 1.26356E7 -478000.0 -0.27 1.159352E7 20600.0 0.01 1.274632E7 -56145.625 -0.0329672994906259 -0.1673 -0.618 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H21 compound treatment 1.341612E7 303000.0 0.17 1.131952E7 -253000.0 -0.14 1.277736E7 -25105.625 -0.0147413918408486 0.0073 0.0327 3188392 PK04_108157 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)CNC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H22 compound treatment 1.288584E7 -228000.0 -0.13 1.153616E7 -36700.0 -0.02 1.275908E7 -43385.625 -0.0254749482789262 -0.1005 -0.761 3071666 PK04_108158 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(Cc4ccccc4)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H23 compound treatment 1.015728E7 -2960000.0 -1.66 9860280.0 -1710000.0 -0.96 1.154732E7 -1255145.625 -0.736989956452062 -1.9408 -0.9437 3188393 PK04_108159 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@@H]6CCCN6C2=O)[C@@H]7O[C@]7(C)[C@H]4C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 H24 compound treatment 1.159884E7 -1510000.0 -0.85 1.051724E7 -1060000.0 -0.59 1.133752E7 -1464945.625 -0.860179242048818 -1.3309 -0.9874 3071711 PK04_108160 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(Cc4ccccc4)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I01 compound treatment 1.321264E7 99100.0 0.06 1.045544E7 -1120000.0 -0.63 1.115884E7 -1643625.625 -0.965095646007007 -0.8882 -0.7701 3188394 PK04_108161 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I02 compound treatment 1.166876E7 -1440000.0 -0.81 9957880.0 -1610000.0 -0.91 1.158368E7 -1218785.625 -0.715640278547877 -1.4066 -0.9953 3071714 PK04_108162 OC[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I03 compound treatment 1.233972E7 -774000.0 -0.43 1.087888E7 -694000.0 -0.39 1.332908E7 526614.375 0.309214721836185 -0.298 -0.4507 3188395 PK04_108163 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I04 compound treatment 1.241604E7 -698000.0 -0.39 1.188068E7 308000.0 0.17 1.189396E7 -908505.625 -0.533451663033287 -0.4341 -0.6346 3071715 PK04_108164 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I05 mock treatment 1.183132E7 -1280000.0 -0.72 1.11276E7 -445000.0 -0.25 1.252876E7 -273705.625 -0.160713061999825 -0.6533 -0.8383 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I06 mock treatment 1.30176E7 -96000.0 -0.05 1.161116E7 38300.0 0.02 1.33136E7 511134.375 0.300125255005691 0.1546 0.5058 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I07 compound treatment 1.313384E7 20300.0 0.01 1.214072E7 568000.0 0.32 1.25656E7 -236865.625 -0.139081540162912 0.1108 0.3178 3188396 PK04_108165 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I08 compound treatment 1.213516E7 -978000.0 -0.55 1.14244E7 -148000.0 -0.08 1.391876E7 1116294.375 0.655459993193166 0.0129 0.015 3071717 PK04_108166 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I09 compound treatment 1.347664E7 363000.0 0.2 1.156512E7 -7750.0 0.0 1.284928E7 46814.375 0.0274882240796406 0.1311 0.6369 3188397 PK04_108167 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I10 compound treatment 1.394876E7 835000.0 0.47 1.313028E7 1560000.0 0.88 1.321796E7 415494.375 0.243967851409534 0.9179 0.8965 3071720 PK04_108168 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I11 compound treatment 1.34896E7 376000.0 0.21 1.295556E7 1380000.0 0.78 1.27214E7 -81065.625 -0.0475996969981146 0.5438 0.6732 3188398 PK04_108169 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I12 compound treatment 1.33152E7 202000.0 0.11 1.147348E7 -99400.0 -0.06 1.405688E7 1254414.375 0.736560584835796 0.4583 0.6133 3071724 PK04_108170 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@]4(CO4)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I13 compound treatment 1.47634E7 1650000.0 0.93 1.165788E7 85000.0 0.05 1.261832E7 -184145.625 -0.108125681551563 0.5002 0.5355 3071725 PK04_108171 COC(=O)[C@H](Cc1ccc(O)cc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I14 compound treatment 1.35096E7 396000.0 0.22 1.307764E7 1500000.0 0.85 1.284476E7 42294.375 0.0248341937131137 0.6318 0.7211 3071727 PK04_108172 C[C@]12COC[C@@]2(C=C(Br)[C@@H]3C1)C(=O)[C@@]43CO4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I15 compound treatment 1.375412E7 641000.0 0.36 1.19684E7 396000.0 0.22 1.321728E7 414814.375 0.243568572504835 0.4769 0.9768 3188399 PK04_108173 COC(=O)[C@H](Cc1ccc(O)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I16 compound treatment 1.311212E7 -1430.0 0.0 1.209264E7 520000.0 0.29 1.289376E7 91294.375 0.0536057618458163 0.1994 0.6704 3071766 PK04_108174 CCCCC[C@H]1OC[C@@]2(C=C(Br)[C@@H]3CC12)C(=O)[C@@]43CO4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I17 compound treatment 1.40556E7 942000.0 0.53 1.109728E7 -476000.0 -0.27 1.353016E7 727694.375 0.427283842655039 0.3976 0.544 3188400 PK04_108175 COC(=O)[C@H](Cc1ccc(OCC#C)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I18 compound treatment 1.340168E7 288000.0 0.16 1.133112E7 -242000.0 -0.14 1.294512E7 142654.375 0.0837630626477674 0.0632 0.278 3071767 PK04_108176 CC1(C)OC[C@@]2(C=C(Br)[C@@H]3C[C@H]12)C(=O)[C@@]43CO4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I19 compound treatment 1.311904E7 5490.0 0.0 1.0856E7 -717000.0 -0.4 1.438892E7 1586454.375 0.931526125300747 0.3066 0.302 3188401 PK04_108177 Oc1ccc(C[C@@H]2N(CC#C)[C@@H](/C=C/C3CC3)[C@@H](Cc4ccccc4)OC2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I20 compound treatment 1.309356E7 -20000.0 -0.01 1.109864E7 -474000.0 -0.27 1.242008E7 -382385.625 -0.22452722576844 -0.2902 -0.8316 3071770 PK04_108178 BrC1=C[C@]23COCC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I21 mock treatment 1.316732E7 53800.0 0.03 1.128904E7 -284000.0 -0.16 1.1638E7 -1164465.625 -0.683744940160767 -0.4696 -0.6681 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I22 mock treatment 1.283884E7 -275000.0 -0.15 1.06208E7 -952000.0 -0.54 1.206716E7 -735305.625 -0.431752977307081 -0.6478 -0.9184 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I23 compound treatment 1.185572E7 -1260000.0 -0.71 1.019464E7 -1380000.0 -0.78 1.124704E7 -1555425.625 -0.913306823368143 -1.3831 -0.9943 3188402 PK04_108179 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccc(OCC#C)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 I24 compound treatment 1.125004E7 -1860000.0 -1.05 1.07272E7 -846000.0 -0.48 1.072776E7 -2074705.625 -1.21821498459161 -1.5825 -0.9447 3071774 PK04_108180 C=CCC1=C[C@H]2[C@H]([C@H]3C=C[C@]2(CC=C)C(=O)[C@@]43CO4)[C@@]5(CO5)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J01 compound treatment 1.117428E7 -1940000.0 -1.09 1.013732E7 -1440000.0 -0.81 1.109036E7 -1712105.625 -1.00530538040961 -1.6758 -0.9927 3188403 PK04_108181 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J02 compound treatment 1.148872E7 -1620000.0 -0.91 1.056952E7 -1000000.0 -0.56 1.097008E7 -1832385.625 -1.0759307725525 -1.4742 -0.97 3071776 PK04_108182 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(Cc5ccccc5)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J03 compound treatment 1.279692E7 -317000.0 -0.18 1.116604E7 -407000.0 -0.23 1.183568E7 -966785.625 -0.567672213865407 -0.5626 -0.8827 3188404 PK04_108183 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@@H](C)NC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J04 compound treatment 1.278284E7 -331000.0 -0.19 1.1054E7 -519000.0 -0.29 1.219416E7 -608305.625 -0.357181770105994 -0.4821 -0.9693 3188405 PK04_108184 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J05 mock treatment 1.284564E7 -268000.0 -0.15 1.182668E7 254000.0 0.14 1.225852E7 -543945.625 -0.319391196125979 -0.1888 -0.4957 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J06 mock treatment 1.212868E7 -985000.0 -0.55 1.171264E7 140000.0 0.08 1.485992E7 2057454.375 1.2080854842906 0.4235 0.3182 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J07 compound treatment 1.222976E7 -884000.0 -0.5 1.00228E7 -1550000.0 -0.87 1.146128E7 -1341185.625 -0.787510481393649 -1.245 -0.9758 3070928 PK04_108185 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@H](C)NC4=O)[C@@H]6O[C@@]61C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J08 compound treatment 1.33E7 186000.0 0.1 1.161752E7 44600.0 0.03 1.279368E7 -8785.625 -0.00515869812807908 0.072 0.6677 3070929 PK04_108186 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(C)C4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J09 compound treatment 1.310068E7 -12900.0 -0.01 9952920.0 -1620000.0 -0.91 1.18652E7 -937265.625 -0.550338812002603 -0.8484 -0.7965 3070930 PK04_108187 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J10 compound treatment 1.38284E7 715000.0 0.4 1.132476E7 -248000.0 -0.14 1.29142E7 111734.375 0.0656076159811722 0.1891 0.4395 3188406 PK04_108188 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)COc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J11 compound treatment 1.394076E7 827000.0 0.46 1.140248E7 -170000.0 -0.1 1.275604E7 -46425.625 -0.0272599598528735 0.1971 0.4148 3188407 PK04_108189 CC(C)C[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J12 compound treatment 1.365888E7 545000.0 0.31 1.138444E7 -188000.0 -0.11 1.377116E7 968694.375 0.568792983879148 0.444 0.6782 3070931 PK04_108190 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(C)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J13 compound treatment 1.480416E7 1690000.0 0.95 1.169224E7 119000.0 0.07 1.295884E7 156374.375 0.0918191017249241 0.64 0.6692 3070932 PK04_108191 OCC(NC(=O)OCC1c2ccccc2-c3ccccc13)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J14 compound treatment 1.381688E7 703000.0 0.4 1.193696E7 364000.0 0.2 1.356704E7 764574.375 0.448938851486347 0.6056 0.958 3070933 PK04_108192 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(C)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J15 compound treatment 1.3457E7 343000.0 0.19 1.08172E7 -756000.0 -0.43 1.20438E7 -758665.625 -0.445469382033202 -0.3914 -0.6064 3188522 PK04_108193 COc1ccc(CN([C@H](COC(=O)OC(C)(C)C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J16 compound treatment 1.316908E7 55500.0 0.03 1.162516E7 52300.0 0.03 1.270572E7 -96745.625 -0.0568065988005795 0.0022 0.031 3188523 PK04_108194 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(C)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J17 compound treatment 1.320064E7 87100.0 0.05 1.150776E7 -65100.0 -0.04 1.265772E7 -144745.625 -0.084990992073431 -0.042 -0.4011 3070934 PK04_108195 CC(=O)OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J18 compound treatment 1.487648E7 1760000.0 0.99 1.17978E7 225000.0 0.13 1.277388E7 -28585.625 -0.0167847603531303 0.6351 0.6361 3188524 PK04_108196 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J19 compound treatment 1.4471E7 1360000.0 0.76 1.270776E7 1130000.0 0.64 1.255776E7 -244705.625 -0.143684991064144 0.7261 0.7224 3070935 PK04_108197 O=C(CCCCCCC(=O)Nc1ccccc1)N/N=C/c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J20 compound treatment 1.36876E7 574000.0 0.32 1.11488E7 -424000.0 -0.24 1.300196E7 199494.375 0.117138081681702 0.116 0.2775 3188525 PK04_108198 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J21 mock treatment 1.223004E7 -884000.0 -0.5 1.162208E7 49200.0 0.03 1.211516E7 -687305.625 -0.403568584034229 -0.5035 -0.7865 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J22 mock treatment 1.255012E7 -563000.0 -0.32 1.16882E7 115000.0 0.06 1.236584E7 -436625.625 -0.256375590166762 -0.2933 -0.711 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J23 compound treatment 1.178344E7 -1330000.0 -0.75 1.063916E7 -934000.0 -0.53 1.177652E7 -1025945.625 -0.602409478574197 -1.0826 -0.9894 3070936 PK04_108199 C/C(=N\O)/C(=O)NCCCCCNC(=O)OCc1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 J24 compound treatment 9283040.0 -3830000.0 -2.15 9821880.0 -1750000.0 -0.99 1.004352E7 -2758945.625 -1.61998351069611 -2.7465 -0.9577 3188526 PK04_108200 OB1C[C@H]2C(=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O)[C@@H](CCc6ccccc6)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K01 compound treatment 1.0756E7 -2360000.0 -1.32 1.052924E7 -1040000.0 -0.59 1.154252E7 -1259945.625 -0.739808395779348 -1.5308 -0.9411 3070937 PK04_108201 COC(=O)[C@H](Cc1ccc(O)cc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K02 compound treatment 1.119732E7 -1920000.0 -1.08 8995840.0 -2580000.0 -1.45 9986920.0 -2815545.625 -1.65321760776368 -2.4134 -0.9856 3188527 PK04_108202 CC1=C[C@]2(CO)C(=O)[C@]3(CO3)[C@H]1[C@@H]4[C@@]5(CO5)C(=O)C(=C[C@@]42C)CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K03 compound treatment 1.213768E7 -976000.0 -0.55 1.08862E7 -687000.0 -0.39 1.142644E7 -1376025.625 -0.80796765351086 -1.0061 -0.9581 3188528 PK04_108203 Oc1ccc(C[C@@H]2N3CC4=CCCC=C[C@@H]4[C@H]3[C@@H](Cc5ccccc5)OC2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K04 compound treatment 1.102116E7 -2090000.0 -1.18 9401680.0 -2170000.0 -1.22 1.106032E7 -1742145.625 -1.02294411319953 -1.9748 -0.9972 3070938 PK04_108204 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K05 compound treatment 1.22382E7 -875000.0 -0.49 1.091356E7 -659000.0 -0.37 1.170052E7 -1101945.625 -0.647034767922878 -0.8717 -0.9757 3188529 PK04_108205 COC(=O)[C@H](Cc1ccccc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K06 compound treatment 1.109972E7 -2010000.0 -1.13 1.026016E7 -1310000.0 -0.74 1.104912E7 -1753345.625 -1.02952047162987 -1.6741 -0.9855 3070939 PK04_108206 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)c4ccccc4)C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K07 mock treatment 1.289152E7 -222000.0 -0.12 1.118104E7 -392000.0 -0.22 1.239056E7 -411905.625 -0.241860627631244 -0.339 -0.9677 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K08 mock treatment 1.248168E7 -632000.0 -0.35 1.100904E7 -564000.0 -0.32 1.205516E7 -747305.625 -0.438799075625294 -0.6415 -0.9907 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K09 compound treatment 1.146092E7 -1650000.0 -0.93 9855000.0 -1720000.0 -0.97 1.134244E7 -1460025.625 -0.85729034173835 -1.5892 -0.9988 3188530 PK04_108207 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K10 compound treatment 1.303288E7 -80700.0 -0.05 1.116152E7 -411000.0 -0.23 1.273244E7 -70025.625 -0.0411172865453588 -0.1836 -0.7665 3188531 PK04_108208 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Oc4ccccc4)cc3)C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K11 compound treatment 1.120852E7 -1910000.0 -1.07 1.007728E7 -1500000.0 -0.84 1.159376E7 -1208705.625 -0.709721555960579 -1.5136 -0.9858 3070940 PK04_108209 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K12 compound treatment 1.296252E7 -151000.0 -0.08 1.135924E7 -214000.0 -0.12 1.332024E7 517774.375 0.304024096075102 0.0571 0.1691 3188532 PK04_108210 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)C(F)(F)F)C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K13 compound treatment 1.072296E7 -2390000.0 -1.34 1.028156E7 -1290000.0 -0.73 1.216724E7 -635225.625 -0.372988517333185 -1.4103 -0.8972 3188533 PK04_108211 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K14 compound treatment 1.342576E7 312000.0 0.18 1.20488E7 476000.0 0.27 1.300748E7 205014.375 0.12037928690808 0.3254 0.9513 3070941 PK04_108212 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4[nH]ccc4c3)C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K15 mock treatment 1.239636E7 -717000.0 -0.4 1.135576E7 -217000.0 -0.12 1.291048E7 108014.375 0.0634233255025262 -0.2665 -0.626 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K16 mock treatment 1.31898E7 76200.0 0.04 1.096468E7 -608000.0 -0.34 1.230492E7 -497545.625 -0.29214628262889 -0.3416 -0.7556 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K17 compound treatment 1.354872E7 435000.0 0.24 1.098156E7 -591000.0 -0.33 1.252904E7 -273425.625 -0.160548653039067 -0.1437 -0.3244 3188534 PK04_108213 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K18 compound treatment 1.3223E7 109000.0 0.06 1.05836E7 -989000.0 -0.56 1.209472E7 -707745.625 -0.415570438169585 -0.5259 -0.754 3070942 PK04_108214 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3cccc4[nH]ccc34)C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K19 compound treatment 1.269012E7 -423000.0 -0.24 1.105052E7 -522000.0 -0.29 1.231088E7 -491585.625 -0.288646720464177 -0.4737 -0.9957 3188535 PK04_108215 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K20 compound treatment 1.280596E7 -308000.0 -0.17 1.123668E7 -336000.0 -0.19 1.201056E7 -791905.625 -0.464987074374651 -0.4775 -0.8993 3070943 PK04_108216 CC(C)Oc1ccc(cc1)C(=O)N2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K21 compound treatment 1.158552E7 -1530000.0 -0.86 1.00616E7 -1510000.0 -0.85 1.12938E7 -1508665.625 -0.885850526921506 -1.4981 -0.9998 3188536 PK04_108217 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K22 compound treatment 1.206632E7 -1050000.0 -0.59 1.026124E7 -1310000.0 -0.74 1.17296E7 -1072865.625 -0.629959722998409 -1.1296 -0.9953 3188537 PK04_108218 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Br)cc3)C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K23 mock treatment 1.18394E7 -1270000.0 -0.72 1.098996E7 -583000.0 -0.33 1.081828E7 -1984185.625 -1.16506391627789 -1.2753 -0.9069 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 K24 mock treatment 1.166024E7 -1450000.0 -0.82 1.029888E7 -1270000.0 -0.72 1.103364E7 -1768825.625 -1.03860993846036 -1.485 -0.9879 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L01 compound treatment 1.173996E7 -1370000.0 -0.77 1.035892E7 -1210000.0 -0.68 1.108676E7 -1715705.625 -1.00741920990507 -1.4216 -0.9864 3070944 PK04_108219 O/N=C(\Cc1ccccc1)/C(=O)NCCCCCNC(=O)OCc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L02 compound treatment 1.226528E7 -848000.0 -0.48 1.180044E7 228000.0 0.13 1.188916E7 -913305.625 -0.536270102360572 -0.5107 -0.7009 3188538 PK04_108220 CCCC[C@H]1OB(O)C[C@H]2C1=C(C)Cn3n2c(=O)n(c4ccccc4)c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L03 compound treatment 1.25104E7 -603000.0 -0.34 1.073172E7 -841000.0 -0.47 1.195124E7 -851225.625 -0.499818287061017 -0.7575 -0.9872 3188539 PK04_108221 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L04 compound treatment 1.24976E7 -616000.0 -0.35 1.132668E7 -246000.0 -0.14 1.245652E7 -345945.625 -0.203130573875467 -0.397 -0.9354 3215882 PK04_108222 CCCC[C@H]1OB(O)C[C@H]2C1=C(COC)Cn3n2c(=O)n(c4ccccc4)c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L05 compound treatment 1.30336E7 -80000.0 -0.04 1.105716E7 -516000.0 -0.29 1.292176E7 119294.375 0.0700466579216464 -0.1531 -0.5069 3188540 PK04_108223 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L06 compound treatment 1.28398E7 -274000.0 -0.15 1.209088E7 518000.0 0.29 1.236352E7 -438945.625 -0.257737835841617 -0.0692 -0.1654 3215880 PK04_108224 CCCC[C@H]1OB(O)C[C@H]2C1=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L07 mock treatment 1.356924E7 456000.0 0.26 1.177176E7 199000.0 0.11 1.2879E7 76534.375 0.0449390609144145 0.2384 0.8424 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L08 mock treatment 1.372568E7 612000.0 0.34 1.19146E7 342000.0 0.19 1.290952E7 107054.375 0.0628596376370692 0.3459 0.8669 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L09 compound treatment 1.348172E7 368000.0 0.21 1.148532E7 -87600.0 -0.05 1.28038E7 1334.375 7.83511453613776E-4 0.0914 0.4299 3188541 PK04_108225 C[C@@H]1ON([C@@H]([C@H]1C(=O)O)c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L10 compound treatment 1.186336E7 -1250000.0 -0.7 9783600.0 -1790000.0 -1.01 1.116776E7 -1634705.625 -0.959858046257136 -1.5411 -0.9888 3188542 PK04_108226 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L11 compound treatment 1.431752E7 1200000.0 0.68 1.16738E7 101000.0 0.06 1.334656E7 544094.375 0.319478538386382 0.6077 0.8102 3070947 PK04_108227 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L12 compound treatment 1.19978E7 -1120000.0 -0.63 1.059168E7 -981000.0 -0.55 1.072808E7 -2074385.625 -1.21802708863646 -1.3839 -0.937 3188543 PK04_108228 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L13 compound treatment 1.55476E7 2430000.0 1.37 1.236084E7 788000.0 0.44 1.434832E7 1545854.375 0.907686825990793 1.5695 0.9233 3188544 PK04_108229 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L14 compound treatment 1.28032E7 -310000.0 -0.17 1.099036E7 -583000.0 -0.33 1.256072E7 -241745.625 -0.141946953478985 -0.3719 -0.9355 3070948 PK04_108230 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)C=CC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L15 mock treatment 1.394488E7 831000.0 0.47 1.169464E7 122000.0 0.07 1.303972E7 237254.375 0.139309804389679 0.3896 0.7917 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L16 mock treatment 1.33736E7 260000.0 0.15 1.211496E7 542000.0 0.31 1.289604E7 93574.375 0.0549445205262768 0.2922 0.8526 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L17 compound treatment 1.393076E7 817000.0 0.46 1.2117E7 544000.0 0.31 1.311268E7 310214.375 0.182150082164413 0.547 0.9413 3188657 PK04_108231 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5cccc(c5)C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L18 compound treatment 1.275084E7 -363000.0 -0.2 1.140116E7 -172000.0 -0.1 1.256984E7 -232625.625 -0.136591918757143 -0.2523 -0.957 3070949 PK04_108232 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)C=CC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L19 compound treatment 1.284452E7 -269000.0 -0.15 1.195964E7 387000.0 0.22 1.292276E7 120294.375 0.0706338327814974 0.0792 0.2889 3188658 PK04_108233 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L20 compound treatment 1.259492E7 -519000.0 -0.29 1.103848E7 -534000.0 -0.3 1.17358E7 -1066665.625 -0.626319238867332 -0.7035 -0.9337 3070950 PK04_108234 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)C=CC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L21 compound treatment 1.2459E7 -655000.0 -0.37 1.070732E7 -866000.0 -0.49 1.19818E7 -820665.625 -0.481874223343968 -0.7718 -0.9924 3188659 PK04_108235 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4cccc(NC(=O)OCC5c6ccccc6-c7ccccc57)c4)c8ccc(I)cc8 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L22 compound treatment 9674640.0 -3440000.0 -1.93 1.052E7 -1050000.0 -0.59 1.184704E7 -955425.625 -0.561001907457499 -1.7813 -0.8495 3070951 PK04_108236 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)C=CC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L23 mock treatment 1.19378E7 -1180000.0 -0.66 1.069412E7 -879000.0 -0.49 1.147904E7 -1323425.625 -0.777082255882694 -1.1155 -0.9842 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 L24 mock treatment 1.221912E7 -894000.0 -0.5 9863720.0 -1710000.0 -0.96 1.23108E7 -491665.625 -0.288693694452965 -1.0122 -0.9012 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M01 compound treatment 1.149572E7 -1620000.0 -0.91 1.096572E7 -607000.0 -0.34 1.078668E7 -2015785.625 -1.18361864184918 -1.4053 -0.918 3188660 PK04_108237 COC(=O)[C@H](Cc1ccccc1)N[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M02 compound treatment 1.234164E7 -772000.0 -0.43 1.02602E7 -1310000.0 -0.74 1.168508E7 -1117385.625 -0.656100747758979 -1.0557 -0.9784 3070952 PK04_108238 CC(C)Cc1ccc(CN2CC[C@@H](N)C2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M03 compound treatment 1.084668E7 -2270000.0 -1.27 9719920.0 -1850000.0 -1.04 1.104392E7 -1758545.625 -1.03257378090109 -1.9335 -0.9951 3188661 PK04_108239 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M04 compound treatment 1.035972E7 -2750000.0 -1.55 8989960.0 -2580000.0 -1.45 1.019952E7 -2602945.625 -1.52838423255934 -2.6149 -0.9996 3070953 PK04_108240 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M05 compound treatment 1.24796E7 -634000.0 -0.36 1.07756E7 -797000.0 -0.45 1.192064E7 -881825.625 -0.51778583777246 -0.7636 -0.9889 3188662 PK04_108241 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@@H]2[C@@H](O)Cc3ccccc3)/C=C/C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M06 compound treatment 1.264248E7 -471000.0 -0.26 1.070248E7 -870000.0 -0.49 1.223E7 -572465.625 -0.336137423128932 -0.6297 -0.9681 3070954 PK04_108242 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)c3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M07 compound treatment 1.263476E7 -479000.0 -0.27 1.089984E7 -673000.0 -0.38 1.252068E7 -281785.625 -0.165457434867422 -0.4695 -0.952 3188663 PK04_108243 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M08 compound treatment 1.278668E7 -327000.0 -0.18 1.100756E7 -565000.0 -0.32 1.251016E7 -292305.625 -0.171634514393055 -0.3888 -0.9589 3188664 PK04_108244 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)Nc3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M09 mock treatment 1.33958E7 282000.0 0.16 1.140056E7 -172000.0 -0.1 1.285396E7 51494.375 0.0302362024237436 0.053 0.2814 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M10 mock treatment 1.2564E7 -550000.0 -0.31 1.148876E7 -84100.0 -0.05 1.266888E7 -133585.625 -0.078438120637493 -0.2508 -0.779 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M11 compound treatment 1.389292E7 779000.0 0.44 1.164392E7 71000.0 0.04 1.316172E7 359254.375 0.21094513729151 0.3976 0.8155 3070955 PK04_108245 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M12 compound treatment 1.335296E7 239000.0 0.13 1.177264E7 200000.0 0.11 1.268608E7 -116385.625 -0.0683387130480545 0.1031 0.548 3188665 PK04_108246 CC(C)Oc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M13 mock treatment 1.423684E7 1120000.0 0.63 1.21546E7 582000.0 0.33 1.378192E7 979454.375 0.575110985371145 0.8854 0.9683 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M14 mock treatment 1.392704E7 813000.0 0.46 1.156868E7 -4190.0 0.0 1.304748E7 245014.375 0.143866281302123 0.3455 0.7212 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M15 compound treatment 1.307792E7 -35600.0 -0.02 1.12918E7 -281000.0 -0.16 1.264448E7 -157985.625 -0.0927651872178592 -0.1565 -0.848 3188666 PK04_108247 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M16 compound treatment 1.31306E7 17000.0 0.01 1.105756E7 -515000.0 -0.29 1.278612E7 -16345.625 -0.00959774006855319 -0.1675 -0.5768 3070994 PK04_108248 CC(C)Oc1ccc(CN2CC[C@@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M17 compound treatment 1.376128E7 648000.0 0.36 1.192228E7 349000.0 0.2 1.302632E7 223854.375 0.131441661267675 0.3995 0.9206 3188667 PK04_108249 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4ccccc4Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M18 compound treatment 1.270848E7 -405000.0 -0.23 1.100716E7 -566000.0 -0.32 1.245736E7 -345105.625 -0.202637346993192 -0.4322 -0.9807 3070995 PK04_108250 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4OCOc4c3)C2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M19 compound treatment 1.275616E7 -357000.0 -0.2 1.12906E7 -282000.0 -0.16 1.221612E7 -586345.625 -0.344287410183665 -0.4064 -0.9472 3188668 PK04_108251 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/c2ccccc2)[C@@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M20 compound treatment 1.279492E7 -319000.0 -0.18 1.105896E7 -514000.0 -0.29 1.248212E7 -320345.625 -0.188098897463279 -0.3789 -0.9749 2133134 PK04_108252 CCCCC(=O)N(CCN1CCOCC1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M21 compound treatment 1.207248E7 -1040000.0 -0.58 1.06342E7 -939000.0 -0.53 1.18598E7 -942665.625 -0.553509556245799 -0.9622 -0.9991 3070996 PK04_108253 O[C@@H](Cc1ccccc1)[C@@H](/C=C/c2ccccc2)N(CC#C)Cc3ccccc3Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M22 compound treatment 1.177588E7 -1340000.0 -0.75 1.109528E7 -478000.0 -0.27 1.142564E7 -1376825.625 -0.808437393398741 -1.0558 -0.9294 2133147 PK04_108254 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCCO4)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M23 compound treatment 1.1485E7 -1630000.0 -0.91 1.058224E7 -991000.0 -0.56 1.152596E7 -1276505.625 -0.749532011458481 -1.2828 -0.9811 3070997 PK04_108255 CCCC/C=C/[C@H]([C@@H](O)Cc1ccccc1)N(CC#Cc2ccccc2)Cc3ccccc3Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 M24 compound treatment 1.103568E7 -2080000.0 -1.17 1.009628E7 -1480000.0 -0.83 1.026264E7 -2539825.625 -1.49132175540554 -2.0147 -0.9742 3188671 PK04_108256 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCCc3c[nH]c4ccccc34)[C@@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N01 compound treatment 1.198944E7 -1120000.0 -0.63 1.426668E7 2690000.0 1.52 1.324268E7 440214.375 0.258482813945053 0.6602 0.397 3188672 PK04_108257 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(OC(=O)OC(C)(C)C)cc4)c5ccc(I)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N02 compound treatment 1.64084E7 3290000.0 1.85 1.202884E7 456000.0 0.26 1.331428E7 511814.375 0.30052453391039 1.3902 0.7346 3070998 PK04_108258 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N03 compound treatment 1.357012E7 457000.0 0.26 1.178416E7 211000.0 0.12 1.401604E7 1213574.375 0.712580363559479 0.6281 0.8194 3188673 PK04_108259 COC(=O)CCCCCCC(=O)Nc1ccc(NC(=O)CCCC[P+](c2ccccc2)(c3ccccc3)c4ccccc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N04 compound treatment 1.73334E7 4220000.0 2.37 1.293228E7 1360000.0 0.77 1.426488E7 1462414.375 0.85869295568482 2.306 0.8753 3070999 PK04_108260 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N05 compound treatment 1.446564E7 1350000.0 0.76 1.16638E7 90900.0 0.05 1.430356E7 1501094.375 0.881404879263859 0.9769 0.8388 3188674 PK04_108261 CC(C)[C@H]1COC(=O)N1C(=O)[C@@H]2[C@@H](C)ON([C@@H]2c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N06 compound treatment 1.726704E7 4150000.0 2.33 1.152256E7 -50300.0 -0.03 1.609216E7 3289694.375 1.93162583359349 2.4458 0.8075 3071000 PK04_108262 OC[C@@H]1[C@H]2[C@@H](CC(=C1[C@H](O)CCc3ccccc3)COc4ccccc4)C(=O)N(Cc5ccccc5)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N07 compound treatment 1.590604E7 2790000.0 1.57 1.21918E7 619000.0 0.35 1.459728E7 1794814.375 1.05386987909932 1.7152 0.8926 3188675 PK04_108263 CC(C)[C@@H](CO)NC(=O)[C@@H]1[C@@H](C)ON([C@@H]1c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N08 compound treatment 1.343552E7 322000.0 0.18 1.278628E7 1210000.0 0.68 1.594744E7 3144974.375 1.84664988787584 1.5649 0.7915 3188676 PK04_108264 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N09 mock treatment 1.339728E7 284000.0 0.16 1.27294E7 1160000.0 0.65 1.345588E7 653414.375 0.383668494065301 0.6894 0.8927 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N10 mock treatment 1.294288E7 -171000.0 -0.1 1.276428E7 1190000.0 0.67 1.479504E7 1992574.375 1.16998957938346 1.0074 0.7451 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N11 compound treatment 1.53702E7 2260000.0 1.27 1.220436E7 631000.0 0.36 1.34874E7 684934.375 0.402176245647807 1.1692 0.8494 3071001 PK04_108265 COC(=O)[C@@H]1N[C@H]2[C@@H](COc3ccccc23)[C@@H]1C(=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N12 compound treatment 1.816124E7 5050000.0 2.84 1.284012E7 1270000.0 0.71 1.594972E7 3147254.375 1.8479886465563 3.1157 0.9008 3188677 PK04_108266 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N13 mock treatment 1.564488E7 2530000.0 1.42 1.223104E7 658000.0 0.37 1.379992E7 997454.375 0.585680132848465 1.3729 0.868 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N14 mock treatment 1.495796E7 1840000.0 1.04 1.306156E7 1490000.0 0.84 1.45436E7 1741134.375 1.02235033262251 1.6722 0.9957 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N15 compound treatment 1.371E7 596000.0 0.34 1.23134E7 741000.0 0.42 1.303152E7 229054.375 0.1344949705389 0.5117 0.928 3071002 PK04_108267 OCC1CC(=NO1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N16 compound treatment 1.350992E7 396000.0 0.22 1.207088E7 498000.0 0.28 1.283628E7 33814.375 0.0198549509015766 0.3019 0.8419 3188788 PK04_108268 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(Cc4ccccc4)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N17 compound treatment 1.351996E7 406000.0 0.23 1.173476E7 162000.0 0.09 1.287948E7 77014.375 0.045220904847143 0.2105 0.8423 3071004 PK04_108269 O[C@H](C=C)[C@H]1CC(=NO1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N18 compound treatment 1.323672E7 123000.0 0.07 1.187352E7 301000.0 0.17 1.259492E7 -207545.625 -0.121865573272078 0.0673 0.3063 3071005 PK04_108270 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N19 compound treatment 1.211976E7 -994000.0 -0.56 1.203932E7 466000.0 0.26 1.316948E7 367014.375 0.215501614203954 -0.0463 -0.0708 3414065 PK04_108271 O[C@@H]([C@H]1CC(=NO1)c2ccccc2)[C@@H]3CC(=NO3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N20 compound treatment 1.334176E7 228000.0 0.13 1.291148E7 1340000.0 0.75 1.325752E7 455054.375 0.267196488865243 0.6633 0.8192 3188790 PK04_108272 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(C)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N21 compound treatment 1.358904E7 475000.0 0.27 1.159552E7 22600.0 0.01 1.279804E7 -4425.625 -0.00259861573912841 0.1601 0.5986 3071008 PK04_108273 CC[C@H](C)C(=O)O[C@H]1CC[C@@]2(C)C(CCC3=C2CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CCCC(C)C)C1(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N22 compound treatment 1.247036E7 -643000.0 -0.36 1.211756E7 545000.0 0.31 1.423328E7 1430814.375 0.840138230113526 0.4535 0.4702 3188791 PK04_108274 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)COc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N23 compound treatment 1.280648E7 -307000.0 -0.17 1.1465E7 -108000.0 -0.06 1.242424E7 -378225.625 -0.22208457835146 -0.2629 -0.9137 3188792 PK04_108275 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)CCl)C(C)(C)C4CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 N24 compound treatment 1.100072E7 -2110000.0 -1.19 1.26526E7 1080000.0 0.61 1.38786E7 1076134.375 0.631879050821547 0.0306 0.0207 3188793 PK04_108276 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O01 compound treatment 1.097196E7 -2140000.0 -1.2 1.086648E7 -706000.0 -0.4 1.129412E7 -1508345.625 -0.885662630966354 -1.4354 -0.9286 3071055 PK04_108277 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O02 compound treatment 1.642944E7 3320000.0 1.86 1.297396E7 1400000.0 0.79 1.382876E7 1026294.375 0.60261425580657 1.8786 0.8901 2129060 PK04_108278 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCC3CCCCC3)[C@@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O03 compound treatment 1.065356E7 -2460000.0 -1.38 1.039152E7 -1180000.0 -0.66 1.396E7 1157534.375 0.679675084413424 -0.7893 -0.4706 3188794 PK04_108279 O[C@@H](Cc1ccccc1)[C@H](NCc2cccc(Cl)c2)/C=C/C3CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O04 compound treatment 1.26724E7 -441000.0 -0.25 1.200276E7 430000.0 0.24 1.310824E7 305774.375 0.179543025786674 0.1003 0.2571 2129057 PK04_108280 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC[C@@H]3CCCO3)[C@@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O05 compound treatment 1.274164E7 -372000.0 -0.21 1.11162E7 -457000.0 -0.26 1.341704E7 614574.375 0.360862622508686 -0.0607 -0.1239 3188796 PK04_108281 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4cccc(Cl)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O06 compound treatment 1.217036E7 -943000.0 -0.53 1.099332E7 -580000.0 -0.33 1.228116E7 -521305.625 -0.306097557298951 -0.6709 -0.9676 2129061 PK04_108282 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC3CCCCCC3)[C@@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O07 compound treatment 1.43356E7 1220000.0 0.69 1.139828E7 -175000.0 -0.1 1.288128E7 78814.375 0.0462778195948749 0.3663 0.5271 3071060 PK04_108283 O[C@@H](Cc1ccccc1)[C@H](NCc2ccccc2Br)/C=C/c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O08 compound treatment 1.29254E7 -188000.0 -0.11 1.370016E7 2130000.0 1.2 1.202656E7 -775905.625 -0.455592276617034 0.3673 0.2857 2129067 PK04_108284 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccccc3F)[C@@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O09 compound treatment 1.300168E7 -112000.0 -0.06 1.18056E7 233000.0 0.13 1.225796E7 -544505.625 -0.319720014047496 -0.1452 -0.4136 3188797 PK04_108285 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC=C3CN2Cc4cccc(Cl)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O10 compound treatment 1.38714E7 758000.0 0.43 1.276112E7 1190000.0 0.67 1.641596E7 3613494.375 2.12175305321327 1.8569 0.8198 2129068 PK04_108286 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccc(F)cc3)[C@@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O11 mock treatment 1.320712E7 93600.0 0.05 1.157236E7 -512.0 0.0 1.257868E7 -223785.625 -0.13140129299606 -0.0457 -0.3228 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O12 mock treatment 1.729452E7 4180000.0 2.35 1.20198E7 447000.0 0.25 1.540952E7 2607054.375 1.53079678726475 2.3849 0.8474 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O13 compound treatment 1.335104E7 237000.0 0.13 1.243336E7 860000.0 0.48 1.252064E7 -281825.625 -0.165480921861816 0.2611 0.4937 3188798 PK04_108287 COC1(C)CN(Cc2ccccc2Br)[C@H](/C=C/c3ccccc3)[C@H](Cc4ccccc4)O1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O14 compound treatment 1.603276E7 2920000.0 1.64 1.24126E7 840000.0 0.47 1.33424E7 539934.375 0.317035890969402 1.4026 0.8081 3071064 PK04_108288 CCCC(=O)N(CCc1c[nH]c2ccccc12)[C@@H]3CC(=C[C@H](Oc4c(I)cc(CO)cc4OC)[C@H]3O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O15 compound treatment 1.26646E7 -449000.0 -0.25 1.120576E7 -367000.0 -0.21 1.236372E7 -438745.625 -0.257620400869646 -0.4136 -0.9955 3188799 PK04_108289 CN1C(=O)C2C3[C@H]([C@@H](O)Cc4ccccc4)N(Cc5cccc(Cl)c5)CC3=CC(C6CC6)C2C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O16 compound treatment 1.397992E7 866000.0 0.49 1.24692E7 896000.0 0.5 1.3481E7 678534.375 0.39841832654476 0.8023 0.995 2133032 PK04_108290 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4ccc(cc4)C(F)(F)F)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O17 compound treatment 1.305196E7 -61600.0 -0.03 1.125824E7 -315000.0 -0.18 1.303368E7 231214.375 0.135763268236178 -0.0438 -0.1942 3071066 PK04_108291 O[C@@H](Cc1ccccc1)[C@H](N(CC#C)CC2=CCCCC2)c3ccccc3Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O18 compound treatment 1.258424E7 -529000.0 -0.3 1.18832E7 310000.0 0.17 1.187376E7 -928705.625 -0.545312595202278 -0.3856 -0.5977 2133035 PK04_108292 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O19 compound treatment 1.243688E7 -677000.0 -0.38 1.194956E7 377000.0 0.21 1.245428E7 -348185.625 -0.204445845561533 -0.2151 -0.4472 3071068 PK04_108293 O=C(Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4ccccc4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O20 compound treatment 1.251968E7 -594000.0 -0.33 1.1426E7 -147000.0 -0.08 1.396144E7 1158974.375 0.68052061621161 0.1526 0.2001 2133267 PK04_108294 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(Cc3ccc(F)cc3)C(=O)C4CCCO4)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O21 compound treatment 1.209284E7 -1020000.0 -0.57 1.102072E7 -552000.0 -0.31 1.158444E7 -1218025.625 -0.715194025654391 -0.9234 -0.954 3071112 PK04_108295 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4cccc(Cl)c4)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O22 compound treatment 1.21158E7 -998000.0 -0.56 1.066868E7 -904000.0 -0.51 1.149556E7 -1306905.625 -0.767382127197954 -1.0605 -0.9838 2133153 PK04_108296 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCOC4)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O23 compound treatment 1.113356E7 -1980000.0 -1.11 1.080204E7 -771000.0 -0.43 1.17576E7 -1044865.625 -0.613518826922579 -1.2468 -0.9289 3188804 PK04_108297 Clc1cccc(CN2CC3=CCCC=CC3[C@@H]2[C@H](Cc4ccccc4)OC(=O)C=C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 O24 compound treatment 1.087396E7 -2240000.0 -1.26 1.034864E7 -1220000.0 -0.69 1.079844E7 -2004025.625 -1.17671346549733 -1.8035 -0.9721 2132929 PK04_108298 CC/C=C/C(=O)N(C[C@@H]1CCCO1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P01 compound treatment 1.003988E7 -3070000.0 -1.73 9520480.0 -2050000.0 -1.16 9400920.0 -3401545.625 -1.99730207563641 -2.8169 -0.9775 3188805 PK04_108299 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)C(C)(C)C)C(C)(C)C4CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P02 compound treatment 1.14908E7 -1620000.0 -0.91 1.04806E7 -1090000.0 -0.61 1.118428E7 -1618185.625 -0.950157917572396 -1.4298 -0.9839 3071118 PK04_108300 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P03 compound treatment 1.131724E7 -1800000.0 -1.01 1.16162E7 43300.0 0.02 1.132888E7 -1473585.625 -0.865252432837931 -1.068 -0.8034 3188806 PK04_108301 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccccc5)C(C)(C)C4CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P04 compound treatment 1.255124E7 -562000.0 -0.32 1.096688E7 -606000.0 -0.34 1.222112E7 -581345.625 -0.341351535884409 -0.5764 -0.9994 3071120 PK04_108302 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(C)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P05 compound treatment 1.271212E7 -401000.0 -0.23 1.114644E7 -426000.0 -0.24 1.3016E7 213534.375 0.125382016714011 -0.1964 -0.5573 3188807 PK04_108303 COc1ccc(cc1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P06 compound treatment 1.237016E7 -743000.0 -0.42 1.152056E7 -52300.0 -0.03 1.161364E7 -1188825.625 -0.698048519746739 -0.6611 -0.8122 3188808 PK04_108304 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P07 compound treatment 1.275444E7 -359000.0 -0.2 1.090452E7 -668000.0 -0.38 1.222512E7 -577345.625 -0.339002836445005 -0.5294 -0.9712 3071124 PK04_108305 COc1cccc(c1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P08 compound treatment 1.33528E7 239000.0 0.13 1.150028E7 -72600.0 -0.04 1.295748E7 155014.375 0.0910205439155267 0.1065 0.6366 3188923 PK04_108306 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P09 compound treatment 1.24216E7 -692000.0 -0.39 1.131952E7 -253000.0 -0.14 1.192268E7 -879785.625 -0.516588001058364 -0.605 -0.9139 3188924 PK04_108307 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(Br)cc5)C(C)(C)C4CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P10 compound treatment 1.251084E7 -603000.0 -0.34 1.179916E7 226000.0 0.13 1.191324E7 -889225.625 -0.522130931735358 -0.4234 -0.6665 3071127 PK04_108308 OC[C@H]1C(=C(COc2ccccc2)Cn3n1c(=O)n(c4ccccc4)c3=O)[C@H](O)CCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P11 mock treatment 1.343492E7 321000.0 0.18 1.165564E7 82800.0 0.05 1.30754E7 272934.375 0.160260203389165 0.2236 0.9097 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P12 mock treatment 1.285392E7 -260000.0 -0.15 1.15618E7 -11100.0 -0.01 1.194408E7 -858385.625 -0.504022459057551 -0.3788 -0.7219 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P13 compound treatment 1.289732E7 -216000.0 -0.12 1.205948E7 487000.0 0.27 1.314088E7 338414.375 0.198708413212213 0.2027 0.5639 3188925 PK04_108309 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(N)cc5)C(C)(C)C4CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P14 compound treatment 1.248544E7 -628000.0 -0.35 1.167108E7 98200.0 0.06 1.228656E7 -515905.625 -0.302926813055755 -0.3467 -0.7403 3071425 PK04_108310 CCCC[C@@H](O)C1=C(C)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P15 compound treatment 1.27602E7 -353000.0 -0.2 1.030132E7 -1270000.0 -0.72 1.239228E7 -410185.625 -0.2408506868723 -0.6669 -0.8541 3188926 PK04_108311 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(nc5)C(F)(F)F)C(C)(C)C4CC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P16 compound treatment 1.283456E7 -279000.0 -0.16 1.128052E7 -292000.0 -0.16 1.200852E7 -793945.625 -0.466184911088748 -0.4546 -0.8766 3215868 PK04_108312 CCCC[C@@H](O)C1=C(COC)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P17 compound treatment 1.21416E7 -972000.0 -0.55 1.131224E7 -261000.0 -0.15 1.210712E7 -695345.625 -0.408289469907432 -0.6356 -0.9115 3188927 PK04_108313 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)F)C(=O)N(C)c3ccccc32 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P18 compound treatment 1.222748E7 -886000.0 -0.5 1.145492E7 -118000.0 -0.07 1.222724E7 -575225.625 -0.337758025742121 -0.5207 -0.8604 3215866 PK04_108314 CCCC[C@@H](O)C1=C(COc2ccccc2)Cn3n([C@H]1CO)c(=O)n(c4ccccc4)c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P19 compound treatment 1.179564E7 -1320000.0 -0.74 1.076716E7 -806000.0 -0.45 1.080812E7 -1994345.625 -1.17102961285398 -1.3653 -0.9366 3071435 PK04_108315 COC(=O)C[C@H]1O[C@@]2(C[C@@H]1[Si](C)(C)C)C(=O)N(C)c3ccccc32 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P20 compound treatment 1.178744E7 -1330000.0 -0.74 1.132408E7 -249000.0 -0.14 1.096524E7 -1837225.625 -1.07877269887418 -1.1337 -0.8599 3071437 PK04_108316 OB1OC(CCc2ccccc2)CC=C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P21 compound treatment 1.056576E7 -2550000.0 -1.43 1.062364E7 -949000.0 -0.53 1.1617E7 -1185465.625 -0.69607561221764 -1.5366 -0.9154 3188929 PK04_108317 COC(=O)C/C=C/C[C@]1(O)C(=O)N(C)c2ccccc21 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P22 compound treatment 1.132316E7 -1790000.0 -1.01 1.130272E7 -270000.0 -0.15 1.104236E7 -1760105.625 -1.03348977368246 -1.2651 -0.8725 3071483 PK04_108318 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)c2ccncc2)c3ccccc3)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P23 compound treatment 1.087344E7 -2240000.0 -1.26 1.042388E7 -1150000.0 -0.65 1.063808E7 -2164385.625 -1.27087282602305 -1.8336 -0.9642 3188930 PK04_108319 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO[Si](C(C)C)(C(C)C)C(C)C)nn2)/C=C/C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2108 P24 compound treatment 9481000.0 -3630000.0 -2.04 8988560.0 -2580000.0 -1.45 9256840.0 -3545625.625 -2.08190222944375 -3.2199 -0.9883 3071486 PK04_108320 CC(=O)OC(C/C=C\B1OC(C)(C)C(C)(C)O1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A01 compound treatment 8005160.0 -5170000.0 -2.9 7647400.0 -5890000.0 -3.31 7211960.0 -4556447.6190476 -2.67543149213303 -5.1335 -0.996 3221174 PK04_130001 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N[C@@H]3[C@H](O)Cc4ccccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A02 compound treatment 9347040.0 -3820000.0 -2.15 9663240.0 -3870000.0 -2.18 9096760.0 -2671647.6190476 -1.56872431628573 -3.4042 -0.9899 3211805 PK04_130002 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A03 compound treatment 1.077284E7 -2400000.0 -1.35 1.11474E7 -2390000.0 -1.34 9508600.0 -2259807.6190476 -1.32690222200466 -2.3199 -1.0 3221177 PK04_130003 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCc4ccccc4F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A04 compound treatment 1.102088E7 -2150000.0 -1.21 1.15514E7 -1980000.0 -1.12 1.024144E7 -1526967.6190476 -0.896596997711402 -1.8597 -0.9927 3080218 PK04_130004 OCCC[C@@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A05 compound treatment 9904640.0 -3270000.0 -1.83 1.059992E7 -2940000.0 -1.65 9558000.0 -2210407.6190476 -1.29789578392802 -2.7626 -0.9904 3221180 PK04_130005 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccc(O)cc2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A06 compound treatment 1.157504E7 -1600000.0 -0.9 1.232496E7 -1210000.0 -0.68 1.057824E7 -1190167.6190476 -0.69883650491356 -1.3144 -0.9919 3211801 PK04_130006 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A07 compound treatment 1.067644E7 -2490000.0 -1.4 1.101876E7 -2520000.0 -1.42 1.02428E7 -1525607.6190476 -0.895798439902004 -2.1441 -0.9814 3221183 PK04_130007 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccccc2O)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A08 compound treatment 8244840.0 -4930000.0 -2.77 9968880.0 -3570000.0 -2.01 8552360.0 -3216047.6190476 -1.88838230998865 -3.8469 -0.985 3080220 PK04_130008 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A09 compound treatment 1.035592E7 -2810000.0 -1.58 1.073408E7 -2800000.0 -1.58 9905120.0 -1863287.6190476 -1.09407564657651 -2.455 -0.9872 3221185 PK04_130009 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccc(O)cc2)c3coc4ccccc4c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A10 compound treatment 1.130864E7 -1860000.0 -1.05 1.196136E7 -1570000.0 -0.89 1.02094E7 -1559007.6190476 -0.91541008022103 -1.644 -0.9973 3080222 PK04_130010 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A11 compound treatment 7013320.0 -6160000.0 -3.46 5465000.0 -8070000.0 -4.54 6001400.0 -5767007.6190476 -3.38624189047435 -6.5748 -0.9904 3221188 PK04_130011 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccc(Cl)cc2)c3coc4ccccc4c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A12 compound treatment 1.182784E7 -1340000.0 -0.75 1.223188E7 -1300000.0 -0.73 1.086084E7 -907567.619047601 -0.532900889519647 -1.1669 -0.9892 3211814 PK04_130012 C[C@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A13 mock treatment 1.188764E7 -1280000.0 -0.72 1.225108E7 -1290000.0 -0.72 1.116668E7 -601727.619047601 -0.353319330382795 -1.0376 -0.9604 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A14 mock treatment 1.223272E7 -938000.0 -0.53 1.221124E7 -1320000.0 -0.75 1.097456E7 -793847.619047601 -0.466127364457383 -1.0038 -0.9792 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A15 compound treatment 1.003528E7 -3140000.0 -1.76 1.019852E7 -3340000.0 -1.88 8966600.0 -2801807.6190476 -1.64515099604394 -3.0512 -0.9985 3221191 PK04_130013 OCCCCCCNC(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2coc3ccccc3c2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A16 compound treatment 1.133756E7 -1830000.0 -1.03 1.186724E7 -1670000.0 -0.94 1.064436E7 -1124047.6190476 -0.660012503180207 -1.5178 -0.9843 3080206 PK04_130014 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A17 compound treatment 1.076584E7 -2400000.0 -1.35 1.119168E7 -2340000.0 -1.32 1.030232E7 -1466087.6190476 -0.860849792243668 -2.0387 -0.9824 3221194 PK04_130015 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N[C@@H]4[C@H](O)Cc5ccccc45 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A18 compound treatment 1.09326E7 -2240000.0 -1.26 1.126284E7 -2270000.0 -1.28 1.062008E7 -1148327.6190476 -0.674269108777391 -1.8538 -0.9674 3211690 PK04_130016 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A19 compound treatment 7723880.0 -5450000.0 -3.06 7453880.0 -6080000.0 -3.42 6679680.0 -5088727.6190476 -2.98797292653456 -5.468 -0.9982 3221197 PK04_130017 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccccc2F)c3coc4ccccc4c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A20 compound treatment 1.017564E7 -2990000.0 -1.68 1.006996E7 -3470000.0 -1.95 9524360.0 -2244047.6190476 -1.31764834621341 -2.8584 -0.9879 3189020 PK04_130018 C[C@@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A21 compound treatment 9436720.0 -3730000.0 -2.1 9609320.0 -3930000.0 -2.21 9550400.0 -2218007.6190476 -1.30235831286289 -3.2389 -0.9774 2019329 PK04_130019 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N3CCCCCCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A22 compound treatment 1.036444E7 -2810000.0 -1.58 9730640.0 -3810000.0 -2.14 7567680.0 -4200727.6190476 -2.46656165098681 -3.5708 -0.9844 3080190 PK04_130020 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A23 compound treatment 8819200.0 -4350000.0 -2.44 8659800.0 -4880000.0 -2.74 8358400.0 -3410007.6190476 -2.00227074580537 -4.1518 -0.992 3221200 PK04_130021 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCCCCCC2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 A24 compound treatment 7106120.0 -6060000.0 -3.41 7374360.0 -6160000.0 -3.47 6207400.0 -5561007.6190476 -3.26528386934502 -5.8543 -0.9997 3211695 PK04_130022 CO[C@@H](CCO)[C@@H](O)c1ccc(O)c(F)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B01 compound treatment 1.032516E7 -2850000.0 -1.6 1.034632E7 -3190000.0 -1.8 9301680.0 -2466727.6190476 -1.44840044400505 -2.7956 -0.9961 3176327 PK04_130023 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B02 compound treatment 1.15726E7 -1600000.0 -0.9 1.248068E7 -1060000.0 -0.59 1.08136E7 -954807.619047601 -0.560639029899012 -1.1848 -0.9763 3221203 PK04_130024 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B03 compound treatment 1.223832E7 -932000.0 -0.52 1.266644E7 -870000.0 -0.49 1.124564E7 -522767.619047601 -0.306956003448954 -0.7621 -0.9774 3052745 PK04_130025 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B04 compound treatment 1.16984E7 -1470000.0 -0.83 1.26636E7 -873000.0 -0.49 1.150416E7 -264247.619047601 -0.155159558680255 -0.8505 -0.8731 3221205 PK04_130026 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B05 compound treatment 1.190604E7 -1260000.0 -0.71 1.26278E7 -908000.0 -0.51 1.14348E7 -333607.619047601 -0.195886006959525 -0.8183 -0.9125 3176512 PK04_130027 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B06 compound treatment 1.197268E7 -1200000.0 -0.67 1.320992E7 -326000.0 -0.18 1.124856E7 -519847.619047601 -0.305241452858189 -0.6706 -0.881 3221207 PK04_130028 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(C)c3ccccc32)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B07 compound treatment 1.240104E7 -769000.0 -0.43 1.311648E7 -420000.0 -0.24 1.209216E7 323752.380952399 0.190099258912176 -0.2761 -0.523 3176123 PK04_130029 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B08 compound treatment 1.292656E7 -244000.0 -0.14 1.3175E7 -361000.0 -0.2 1.130456E7 -463847.619047601 -0.272359660706529 -0.3537 -0.9652 3221209 PK04_130030 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B09 compound treatment 1.32522E7 81900.0 0.05 1.378412E7 248000.0 0.14 1.171564E7 -52767.6190476008 -0.0309838193189498 0.0893 0.5942 3052645 PK04_130031 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B10 compound treatment 1.262644E7 -544000.0 -0.31 1.269816E7 -838000.0 -0.47 1.170776E7 -60647.6190476008 -0.0356107572145763 -0.4693 -0.8334 3221211 PK04_130032 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B11 compound treatment 1.204684E7 -1120000.0 -0.63 1.358232E7 46200.0 0.03 1.034508E7 -1423327.6190476 -0.835742195236436 -0.8318 -0.7941 3052831 PK04_130033 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B12 compound treatment 1.28868E7 -284000.0 -0.16 1.386804E7 332000.0 0.19 1.184564E7 77232.3809523992 0.0453489124616897 0.0421 0.1687 3221213 PK04_130034 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B13 mock treatment 1.377024E7 600000.0 0.34 1.435156E7 815000.0 0.46 1.25656E7 797192.380952399 0.468091324560068 0.7298 0.9901 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B14 mock treatment 1.355424E7 384000.0 0.22 1.406212E7 526000.0 0.3 1.210112E7 332712.380952399 0.195360345656442 0.4082 0.9834 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B15 compound treatment 1.29616E7 -209000.0 -0.12 1.324868E7 -287000.0 -0.16 1.214696E7 378552.380952399 0.222276441232015 -0.0328 -0.1097 3176778 PK04_130035 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B16 compound treatment 1.219656E7 -974000.0 -0.55 1.227688E7 -1260000.0 -0.71 1.111036E7 -658047.619047601 -0.386389018489607 -0.9481 -0.9723 3221214 PK04_130036 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccccc32)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B17 compound treatment 1.307764E7 -92700.0 -0.05 1.302856E7 -508000.0 -0.29 1.185868E7 90272.3809523992 0.0530056726341477 -0.1644 -0.5569 3176195 PK04_130037 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B18 compound treatment 1.183344E7 -1340000.0 -0.75 1.198332E7 -1550000.0 -0.87 1.094916E7 -819247.619047601 -0.4810416058976 -1.2159 -0.9737 3221216 PK04_130038 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(CC=C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B19 compound treatment 1.230548E7 -865000.0 -0.49 1.279216E7 -744000.0 -0.42 1.181628E7 47872.3809523992 0.0281094585764622 -0.506 -0.7882 3052584 PK04_130039 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B20 compound treatment 1.256876E7 -602000.0 -0.34 1.296708E7 -569000.0 -0.32 1.2131E7 362592.380952399 0.212905130468792 -0.2571 -0.5022 3221218 PK04_130040 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B21 compound treatment 1.227844E7 -892000.0 -0.5 1.212608E7 -1410000.0 -0.79 1.08848E7 -883607.619047601 -0.518832179877615 -1.047 -0.9763 3176736 PK04_130041 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B22 compound treatment 1.058532E7 -2590000.0 -1.45 1.076692E7 -2770000.0 -1.56 9145160.0 -2623247.6190476 -1.54030505306894 -2.6276 -0.9995 3221220 PK04_130042 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(C)c3c2cc(C)cc3Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B23 compound treatment 1.152672E7 -1640000.0 -0.92 1.168748E7 -1850000.0 -1.04 1.0104E7 -1664407.6190476 -0.977298310449333 -1.698 -0.9988 3052927 PK04_130043 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 B24 compound treatment 9999800.0 -3170000.0 -1.78 9855600.0 -3680000.0 -2.07 8650400.0 -3118007.6190476 -1.83081568672885 -3.2813 -0.9978 3221222 PK04_130044 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C01 compound treatment 8163440.0 -5010000.0 -2.81 8834760.0 -4700000.0 -2.65 7962480.0 -3805927.6190476 -2.2347450163176 -4.4418 -0.9955 3221224 PK04_130045 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCc3ccc(Cl)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C02 compound treatment 8782320.0 -4390000.0 -2.46 9154560.0 -4380000.0 -2.47 8569240.0 -3199167.6190476 -1.87847079835437 -3.9315 -0.9926 3211914 PK04_130046 COc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C03 compound treatment 1.224788E7 -922000.0 -0.52 1.323864E7 -297000.0 -0.17 1.1096E7 -672407.619047601 -0.394820849477069 -0.6238 -0.9274 3221227 PK04_130047 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCOCCOCCOCCOCC2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C04 compound treatment 1.260944E7 -561000.0 -0.32 1.32924E7 -244000.0 -0.14 1.122104E7 -547367.619047601 -0.321400505001291 -0.4467 -0.9493 3211809 PK04_130048 CSc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C05 compound treatment 1.277876E7 -392000.0 -0.22 1.287564E7 -660000.0 -0.37 1.152348E7 -244927.619047601 -0.143815340387932 -0.4247 -0.9327 2019446 PK04_130049 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2coc3ccccc3c2=O)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C06 compound treatment 1.28798E7 -291000.0 -0.16 1.315116E7 -385000.0 -0.22 1.163824E7 -130167.619047601 -0.0764311534714228 -0.2635 -0.9348 3069417 PK04_130050 C[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C07 compound treatment 1.241864E7 -752000.0 -0.42 1.334492E7 -191000.0 -0.11 1.100248E7 -765927.619047601 -0.449733442370341 -0.5656 -0.9032 3221230 PK04_130051 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccc(O)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C08 compound treatment 1.348772E7 317000.0 0.18 1.416828E7 632000.0 0.36 1.17364E7 -32007.6190476008 -0.0187940692284415 0.2975 0.7467 3080227 PK04_130052 CSc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C09 compound treatment 1.264684E7 -523000.0 -0.29 1.34248E7 -111000.0 -0.06 1.15712E7 -197207.619047601 -0.115795356075839 -0.2728 -0.8468 3221232 PK04_130053 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)O)c2cccs2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C10 compound treatment 1.314136E7 -29000.0 -0.02 1.232328E7 -1210000.0 -0.68 1.073488E7 -1033527.6190476 -0.606861434866488 -0.7539 -0.8252 3080226 PK04_130054 COc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C11 mock treatment 1.37866E7 616000.0 0.35 1.409492E7 559000.0 0.31 1.262224E7 853832.380952399 0.501348908622033 0.6709 0.9785 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C12 mock treatment 1.403884E7 869000.0 0.49 1.424352E7 707000.0 0.4 1.20632E7 294792.380952399 0.173094674970889 0.6115 0.9363 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C13 compound treatment 1.437224E7 1200000.0 0.68 1.46028E7 1070000.0 0.6 1.288672E7 1118312.3809524 0.656644915555445 1.1155 0.9988 3221235 PK04_130055 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCCCCCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C14 compound treatment 9620680.0 -3550000.0 -1.99 8650920.0 -4890000.0 -2.75 7783560.0 -3984847.6190476 -2.33980234224216 -4.0897 -0.9915 3080272 PK04_130056 OCCC[C@H](O)c1ccc(O)c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C15 mock treatment 1.328332E7 113000.0 0.06 1.33248E7 -211000.0 -0.12 1.196928E7 200872.380952399 0.117947212133676 0.0361 0.2013 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C16 mock treatment 1.327496E7 105000.0 0.06 1.347824E7 -57900.0 -0.03 1.194224E7 173832.380952399 0.102070003923303 0.074 0.6059 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C17 compound treatment 1.252532E7 -645000.0 -0.36 1.322728E7 -309000.0 -0.17 1.146432E7 -304087.619047601 -0.178552605096721 -0.4126 -0.9384 3221238 PK04_130057 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccc(O)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C18 compound treatment 9418400.0 -3750000.0 -2.11 8340480.0 -5200000.0 -2.92 7481280.0 -4287127.6190476 -2.51729355887794 -4.3586 -0.9913 3080228 PK04_130058 OCCC[C@@H](O)c1ccc(O)c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C19 compound treatment 1.2051E7 -1120000.0 -0.63 1.167556E7 -1860000.0 -1.05 9748600.0 -2019807.6190476 -1.1859802556404 -1.6524 -0.9705 2019457 PK04_130059 Nc1ccccc1NC(=O)C2=C[C@@H](C[C@H](OCCCCO)O2)c3coc4ccccc4c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C20 compound treatment 1.285352E7 -317000.0 -0.18 1.293444E7 -602000.0 -0.34 1.115208E7 -616327.619047601 -0.361892083336621 -0.5072 -0.9631 3080205 PK04_130060 OCCC[C@@H](O)c1ccc(O)c(F)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C21 compound treatment 1.212684E7 -1040000.0 -0.59 1.189436E7 -1640000.0 -0.92 1.034308E7 -1425327.6190476 -0.836916544956139 -1.3552 -0.9836 3221241 PK04_130061 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)c4cccs4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C22 compound treatment 1.123356E7 -1940000.0 -1.09 9797640.0 -3740000.0 -2.1 9244160.0 -2524247.6190476 -1.48217474194368 -2.6988 -0.9658 3211908 PK04_130062 COc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C23 compound treatment 1.18266E7 -1340000.0 -0.75 1.12652E7 -2270000.0 -1.28 9857840.0 -1910567.6190476 -1.12183727395027 -1.8215 -0.9789 2019323 PK04_130063 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccccc3O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 C24 compound treatment 1.014172E7 -3030000.0 -1.7 1.014056E7 -3400000.0 -1.91 9711160.0 -2057247.6190476 -1.20796408239323 -2.7831 -0.9836 3211812 PK04_130064 C[C@@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D01 compound treatment 1.231692E7 -853000.0 -0.48 1.215788E7 -1380000.0 -0.78 1.008224E7 -1686167.6190476 -0.990075235399692 -1.2963 -0.963 3175965 PK04_130065 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D02 compound treatment 8976400.0 -4190000.0 -2.36 1.018092E7 -3360000.0 -1.89 1.0071E7 -1697407.6190476 -0.996675080824419 -3.0259 -0.9517 3221243 PK04_130066 COc1cc2c3N(C(=O)[C@@]42O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)C(C)(C)C=C(C)c3c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D03 compound treatment 1.296192E7 -208000.0 -0.12 1.333004E7 -206000.0 -0.12 1.1504E7 -264407.619047601 -0.155253506657831 -0.2242 -0.9902 3176379 PK04_130067 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D04 compound treatment 1.135276E7 -1820000.0 -1.02 1.20882E7 -1450000.0 -0.82 1.067004E7 -1098367.6190476 -0.644933852779232 -1.4323 -0.9832 3221245 PK04_130068 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(C)c3ccccc32)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D05 compound treatment 1.22444E7 -926000.0 -0.52 1.318696E7 -349000.0 -0.2 1.221496E7 446552.380952399 0.262204331701888 -0.2624 -0.4268 3052839 PK04_130069 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D06 compound treatment 1.22836E7 -887000.0 -0.5 1.344036E7 -95800.0 -0.05 1.183224E7 63832.3809523992 0.0374807693396853 -0.297 -0.5913 3221246 PK04_130070 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(C)c5c4cc(C)cc5Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D07 compound treatment 1.357424E7 404000.0 0.23 1.356852E7 32400.0 0.02 1.343172E7 1663312.3809524 0.97665521417428 0.7054 0.7034 3176048 PK04_130071 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D08 compound treatment 1.335536E7 185000.0 0.1 1.403824E7 502000.0 0.28 1.224524E7 476832.380952399 0.279983986458178 0.3848 0.9359 3221248 PK04_130072 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D09 compound treatment 1.343844E7 268000.0 0.15 1.395512E7 419000.0 0.24 1.294112E7 1172712.3809524 0.688587227931343 0.6207 0.8351 3175970 PK04_130073 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCN(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D10 compound treatment 1.32462E7 75900.0 0.04 1.391408E7 378000.0 0.21 1.180768E7 39272.3809523992 0.023059754781743 0.1608 0.7367 3221250 PK04_130074 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D11 mock treatment 1.455672E7 1390000.0 0.78 1.494688E7 1410000.0 0.79 1.20728E7 304392.380952399 0.178731553625459 1.0113 0.8977 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D12 mock treatment 1.3776E7 606000.0 0.34 1.477284E7 1240000.0 0.7 1.302764E7 1259232.3809524 0.739389596805658 1.0252 0.9573 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D13 compound treatment 1.494896E7 1780000.0 1.0 1.444444E7 908000.0 0.51 1.18994E7 130992.380952399 0.0769154329272834 0.9164 0.8146 3176675 PK04_130075 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D14 compound treatment 1.291028E7 -260000.0 -0.15 1.327564E7 -260000.0 -0.15 1.228644E7 518032.380952399 0.304175590684043 0.0066 0.018 3221251 PK04_130076 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D15 mock treatment 1.334572E7 175000.0 0.1 1.389616E7 360000.0 0.2 1.165852E7 -109887.619047601 -0.0645232473136431 0.1366 0.5829 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D16 mock treatment 1.33854E7 215000.0 0.12 1.455656E7 1020000.0 0.57 1.224864E7 480232.380952399 0.281980380981672 0.5642 0.8664 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D17 compound treatment 1.252988E7 -640000.0 -0.36 1.31688E7 -367000.0 -0.21 1.152476E7 -243647.619047601 -0.143063756567323 -0.4097 -0.9334 3052531 PK04_130077 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D18 compound treatment 1.228932E7 -881000.0 -0.49 1.188196E7 -1650000.0 -0.93 1.199124E7 222832.380952399 0.130841572056006 -0.7478 -0.7037 3221253 PK04_130078 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D19 compound treatment 1.306096E7 -109000.0 -0.06 1.29774E7 -559000.0 -0.31 1.107188E7 -696527.619047601 -0.408983507096677 -0.4532 -0.8722 3052793 PK04_130079 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D20 compound treatment 1.214208E7 -1030000.0 -0.58 1.196856E7 -1570000.0 -0.88 1.084656E7 -921847.619047601 -0.54128574651832 -1.1554 -0.9747 3221255 PK04_130080 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D21 compound treatment 1.243608E7 -734000.0 -0.41 1.233876E7 -1200000.0 -0.67 1.085144E7 -916967.619047601 -0.538420333202247 -0.9381 -0.9811 3052828 PK04_130081 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D22 compound treatment 1.24118E7 -759000.0 -0.43 1.28766E7 -660000.0 -0.37 1.116612E7 -602287.619047601 -0.353648148304311 -0.6645 -0.9968 3221256 PK04_130082 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D23 compound treatment 1.16038E7 -1570000.0 -0.88 1.219448E7 -1340000.0 -0.76 1.08544E7 -914007.619047601 -0.536682295617088 -1.2539 -0.9813 3052592 PK04_130083 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 D24 compound treatment 1.1565E7 -1610000.0 -0.9 1.126124E7 -2270000.0 -1.28 9991960.0 -1776447.6190476 -1.04308538174705 -1.8621 -0.9896 3221257 PK04_130084 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(C)c3c2cc(C)cc3Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E01 mock treatment 1.188036E7 -1290000.0 -0.72 1.219292E7 -1340000.0 -0.76 1.132264E7 -445767.619047601 -0.261743539240421 -1.006 -0.9319 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E02 mock treatment 1.359272E7 422000.0 0.24 1.385932E7 323000.0 0.18 1.23522E7 583792.380952399 0.342788209467849 0.4399 0.9672 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E03 compound treatment 1.164376E7 -1530000.0 -0.86 1.169012E7 -1850000.0 -1.04 1.024416E7 -1524247.6190476 -0.894999882092607 -1.6117 -0.9965 2019322 PK04_130085 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccccc3N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E04 compound treatment 1.212516E7 -1050000.0 -0.59 1.284156E7 -695000.0 -0.39 1.145284E7 -315567.619047601 -0.185293372487812 -0.6716 -0.921 3080210 PK04_130086 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E05 compound treatment 1.218608E7 -984000.0 -0.55 1.273136E7 -805000.0 -0.45 1.109892E7 -669487.619047601 -0.393106298886304 -0.8077 -0.9902 3221259 PK04_130087 OCCCCCCNC(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cccs2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E06 compound treatment 1.268608E7 -484000.0 -0.27 1.390184E7 366000.0 0.21 1.1758E7 -10407.6190476008 -0.00611109225565834 -0.0417 -0.1223 3211802 PK04_130088 OCCC[C@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E07 compound treatment 1.28936E7 -277000.0 -0.16 1.51166E7 1580000.0 0.89 1.17732E7 4792.38095239922 0.00281396561407797 0.4255 0.4712 3221261 PK04_130089 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCc4ccc(Cl)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E08 compound treatment 1.151248E7 -1660000.0 -0.93 1.3137E7 -399000.0 -0.22 1.1083E7 -685407.619047601 -0.402454122655133 -0.8997 -0.8659 3080219 PK04_130090 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E09 mock treatment 1.417672E7 1010000.0 0.57 1.39608E7 425000.0 0.24 1.244756E7 679152.380952399 0.398781204103248 0.6946 0.949 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E10 mock treatment 1.349312E7 323000.0 0.18 1.41404E7 604000.0 0.34 1.189364E7 125232.380952399 0.0735333057345412 0.3435 0.8754 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E11 compound treatment 1.355648E7 386000.0 0.22 1.322296E7 -313000.0 -0.18 1.201444E7 246032.380952399 0.144464028804551 0.1069 0.3396 3221264 PK04_130091 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cc(=O)n(c3ccccc3)n2C)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E12 compound treatment 1.31862E7 15900.0 0.01 1.312584E7 -410000.0 -0.23 1.227712E7 508712.380952399 0.298703120990231 0.0443 0.1172 3069920 PK04_130092 O[C@@H](CC=C)c1ccc(O)c(F)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E13 compound treatment 1.355428E7 384000.0 0.22 1.69108E7 3370000.0 1.9 1.188792E7 119512.380952399 0.0701746655361931 1.2618 0.6595 3221266 PK04_130093 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccccc4N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E14 compound treatment 1.351096E7 341000.0 0.19 1.37286E7 192000.0 0.11 1.19026E7 134192.380952399 0.0787943924788068 0.2185 0.9355 3211678 PK04_130094 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E15 compound treatment 1.363756E7 467000.0 0.26 1.335724E7 -179000.0 -0.1 1.217356E7 405152.380952399 0.237895292504054 0.2307 0.6266 3221269 PK04_130095 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N4CCOCCOCCOCCOCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E16 compound treatment 1.047948E7 -2690000.0 -1.51 8281040.0 -5260000.0 -2.96 7333320.0 -4435087.6190476 -2.6041719511415 -4.084 -0.9676 3211906 PK04_130096 CSc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E17 mock treatment 1.4598E7 1430000.0 0.8 1.461568E7 1080000.0 0.61 1.141808E7 -350327.619047601 -0.205703570616235 0.6951 0.6768 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E18 mock treatment 1.250624E7 -664000.0 -0.37 1.296592E7 -570000.0 -0.32 1.180236E7 33952.3809523992 0.0199359845273353 -0.3892 -0.7902 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E19 compound treatment 1.25982E7 -572000.0 -0.32 1.317088E7 -365000.0 -0.21 1.022704E7 -1541367.6190476 -0.905052315693257 -0.8268 -0.8418 2019458 PK04_130097 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccccc2O)c3coc4ccccc4c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E20 compound treatment 1.250652E7 -664000.0 -0.37 1.1554E7 -1980000.0 -1.12 1.094456E7 -823847.619047601 -0.483742610252915 -1.1387 -0.8952 3211804 PK04_130098 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E21 compound treatment 1.275436E7 -416000.0 -0.23 1.235704E7 -1180000.0 -0.66 1.043304E7 -1335367.6190476 -0.784094294563936 -0.9708 -0.9215 3221271 PK04_130099 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccccc2F)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E22 compound treatment 1.20114E7 -1160000.0 -0.65 1.235828E7 -1180000.0 -0.66 1.043852E7 -1329887.6190476 -0.780876576331952 -1.2095 -0.9965 3211680 PK04_130100 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E23 compound treatment 1.185124E7 -1320000.0 -0.74 1.152572E7 -2010000.0 -1.13 1.016248E7 -1605927.6190476 -0.942960324645242 -1.6256 -0.9859 2019464 PK04_130101 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCCCCCC2)c3coc4ccccc4c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 E24 compound treatment 1.014416E7 -3030000.0 -1.7 7548360.0 -5990000.0 -3.37 7852720.0 -3915687.6190476 -2.29919332893486 -4.2548 -0.9626 3211909 PK04_130102 CSc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F01 mock treatment 1.186428E7 -1310000.0 -0.73 1.237248E7 -1160000.0 -0.66 1.126804E7 -500367.619047601 -0.29380328658829 -0.9713 -0.9463 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F02 mock treatment 1.321904E7 48700.0 0.03 1.378848E7 252000.0 0.14 1.14462E7 -322207.619047601 -0.189192213557223 -0.0114 -0.0479 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F03 compound treatment 1.277516E7 -395000.0 -0.22 1.341348E7 -123000.0 -0.07 1.133368E7 -434727.619047601 -0.255261128787666 -0.3154 -0.9135 3176785 PK04_130103 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F04 compound treatment 1.205428E7 -1120000.0 -0.63 1.209676E7 -1440000.0 -0.81 1.05674E7 -1201007.6190476 -0.705201480394346 -1.2369 -0.9945 3221273 PK04_130104 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(C)c5c4cc(C)cc5Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F05 compound treatment 1.302772E7 -143000.0 -0.08 1.290936E7 -627000.0 -0.35 1.154604E7 -222367.619047601 -0.130568675549692 -0.3253 -0.8458 3176500 PK04_130105 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F06 compound treatment 1.278564E7 -385000.0 -0.22 1.331856E7 -218000.0 -0.12 1.220752E7 439112.380952399 0.257835750744596 -0.0466 -0.1302 3221274 PK04_130106 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(CC=C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F07 compound treatment 1.226212E7 -908000.0 -0.51 1.32446E7 -292000.0 -0.16 1.155308E7 -215327.619047601 -0.12643496453634 -0.4623 -0.8396 3052886 PK04_130107 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F08 compound treatment 1.337348E7 203000.0 0.11 1.504276E7 1510000.0 0.85 1.237244E7 604032.380952399 0.354672628631235 0.7603 0.8208 3221275 PK04_130108 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(c3ccccc32)c4ccccc4)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F09 mock treatment 1.332288E7 153000.0 0.09 1.382624E7 290000.0 0.16 1.234812E7 579712.380952399 0.340392536039657 0.3403 0.879 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F10 mock treatment 1.386484E7 695000.0 0.39 1.384292E7 307000.0 0.17 1.251444E7 746032.380952399 0.438051458730087 0.5778 0.945 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F11 compound treatment 1.427244E7 1100000.0 0.62 1.41348E7 599000.0 0.34 1.20558E7 287392.380952399 0.168749581007991 0.6494 0.896 3052654 PK04_130109 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F12 compound treatment 1.41344E7 964000.0 0.54 1.36946E7 158000.0 0.09 1.21362E7 367792.380952399 0.215958439740017 0.4888 0.8288 3221277 PK04_130110 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F13 compound treatment 1.42132E7 1040000.0 0.59 1.408244E7 546000.0 0.31 1.228E7 511592.380952399 0.300394184586602 0.6892 0.9485 3052647 PK04_130111 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F14 compound treatment 1.694412E7 3770000.0 2.12 1.35184E7 -17700.0 -0.01 1.169872E7 -69687.6190476008 -0.04091881794763 1.1944 0.5634 3221279 PK04_130112 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F15 compound treatment 1.387072E7 700000.0 0.39 1.389728E7 361000.0 0.2 1.224128E7 472872.380952399 0.277658774013168 0.5048 0.9658 3176113 PK04_130113 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F16 compound treatment 1.276108E7 -409000.0 -0.23 1.211208E7 -1420000.0 -0.8 1.018392E7 -1584487.6190476 -0.930371295650035 -1.1327 -0.9066 3221280 PK04_130114 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(CC=C)c5ccccc54)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F17 mock treatment 1.338292E7 213000.0 0.12 1.367324E7 137000.0 0.08 1.191916E7 150752.380952399 0.0885180081579406 0.1646 0.9828 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F18 mock treatment 1.350908E7 339000.0 0.19 1.418544E7 649000.0 0.37 1.38292E7 2060792.3809524 1.21004547746788 1.0195 0.7976 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F19 compound treatment 1.311084E7 -59500.0 -0.03 1.35544E7 18300.0 0.01 1.237868E7 610272.380952399 0.358336599756706 0.1935 0.5375 3052888 PK04_130115 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F20 compound treatment 1.099572E7 -2170000.0 -1.22 1.032852E7 -3210000.0 -1.81 8838440.0 -2929967.6190476 -1.72040332608246 -2.7409 -0.987 3221282 PK04_130116 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(c3ccccc32)c4ccccc4)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F21 compound treatment 1.21932E7 -977000.0 -0.55 1.279768E7 -738000.0 -0.42 1.150404E7 -264367.619047601 -0.155230019663437 -0.6465 -0.916 3176499 PK04_130117 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F22 compound treatment 1.212852E7 -1040000.0 -0.59 1.203356E7 -1500000.0 -0.85 1.064E7 -1128407.6190476 -0.662572585569158 -1.2087 -0.988 3221283 PK04_130118 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F23 compound treatment 1.229872E7 -872000.0 -0.49 1.227948E7 -1260000.0 -0.71 1.055152E7 -1216887.6190476 -0.714525817168781 -1.1036 -0.9868 3175968 PK04_130119 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 F24 compound treatment 1.174556E7 -1420000.0 -0.8 1.116312E7 -2370000.0 -1.34 9534320.0 -2234087.6190476 -1.31180008460929 -1.9906 -0.9777 3221284 PK04_130120 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G01 compound treatment 1.130744E7 -1860000.0 -1.05 1.152896E7 -2010000.0 -1.13 9953000.0 -1815407.6190476 -1.06596171428685 -1.8719 -0.9995 2019328 PK04_130121 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N3CCOCCOCCOCCOCC3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G02 compound treatment 2211840.0 -1.1E7 -6.16 3740160.0 -9800000.0 -5.51 3287280.0 -8481127.6190476 -4.97990492109334 -9.6125 -0.9963 3211907 PK04_130122 COc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G03 mock treatment 1.277988E7 -390000.0 -0.22 1.2631E7 -905000.0 -0.51 1.165504E7 -113367.619047601 -0.0665666158259248 -0.4592 -0.822 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G04 mock treatment 1.299164E7 -179000.0 -0.1 1.309416E7 -442000.0 -0.25 1.213704E7 368632.380952399 0.216451666622292 -0.0766 -0.2223 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G05 compound treatment 1.318924E7 18900.0 0.01 1.35292E7 -6930.0 0.0 1.187216E7 103752.380952399 0.0609207897449402 0.0391 0.6303 3221285 PK04_130123 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCCCCCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G06 compound treatment 1.009552E7 -3070000.0 -1.73 1.076896E7 -2770000.0 -1.56 1.0637E7 -1131407.6190476 -0.664334110148711 -2.28 -0.9426 3211815 PK04_130124 COc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G07 compound treatment 1.245688E7 -713000.0 -0.4 1.345852E7 -77600.0 -0.04 1.284244E7 1074032.3809524 0.630644812761239 0.1075 0.1437 3221287 PK04_130125 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCc3ccccc3F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G08 compound treatment 1.253828E7 -632000.0 -0.36 1.350052E7 -35600.0 -0.02 1.134932E7 -419087.619047601 -0.246077713979595 -0.3586 -0.8293 3211803 PK04_130126 CSc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G09 compound treatment 1.399768E7 827000.0 0.46 1.379084E7 255000.0 0.14 1.218056E7 412152.380952399 0.242005516523011 0.4908 0.9035 3221289 PK04_130127 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N4CCCCCCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G10 compound treatment 1.369312E7 523000.0 0.29 1.434256E7 806000.0 0.45 1.192504E7 156632.380952399 0.0919705963338649 0.4847 0.8839 3211807 PK04_130128 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G11 compound treatment 1.402944E7 859000.0 0.48 1.36844E7 148000.0 0.08 1.173732E7 -31087.6190476008 -0.0182538683573785 0.3162 0.6453 2019311 PK04_130129 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2ccc(cc2)C(=O)OC)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G12 compound treatment 1.0905E7 -2270000.0 -1.27 1.050516E7 -3030000.0 -1.71 9193920.0 -2574487.6190476 -1.5116744069026 -2.5924 -0.993 3211818 PK04_130130 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G13 compound treatment 1.388472E7 714000.0 0.4 1.392896E7 393000.0 0.22 1.145264E7 -315767.619047601 -0.185410807459782 0.2523 0.5104 3221292 PK04_130131 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccccc4O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G14 compound treatment 1.42016E7 1030000.0 0.58 1.421416E7 678000.0 0.38 1.163552E7 -132887.619047601 -0.0780282690902178 0.5097 0.7302 3080207 PK04_130132 OCCC[C@H](O)c1ccc(O)c(F)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G15 compound treatment 1.37638E7 593000.0 0.33 1.41822E7 646000.0 0.36 1.177628E7 7872.38095239922 0.00462246418241927 0.4051 0.8211 2019470 PK04_130133 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)O)c2coc3ccccc3c2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G16 compound treatment 1.296408E7 -206000.0 -0.12 1.210828E7 -1430000.0 -0.8 1.019784E7 -1570567.6190476 -0.922197821600908 -1.0634 -0.8654 3080225 PK04_130134 COc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G17 compound treatment 1.349812E7 328000.0 0.18 1.354644E7 10300.0 0.01 1.140328E7 -365127.619047601 -0.214393758542031 -0.0141 -0.05 3221294 PK04_130135 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)c4coc5ccccc5c4=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G18 compound treatment 1.478756E7 1620000.0 0.91 1.420152E7 665000.0 0.37 1.174332E7 -25087.6190476008 -0.0147308191982721 0.7322 0.7451 3211806 PK04_130136 CO[C@@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G19 mock treatment 1.343432E7 264000.0 0.15 1.347848E7 -57600.0 -0.03 1.17822E7 13792.3809523992 0.00809853935273762 0.0716 0.4707 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G20 mock treatment 1.336156E7 191000.0 0.11 1.30626E7 -474000.0 -0.27 1.1603E7 -165407.619047601 -0.0971231955325747 -0.148 -0.4877 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G21 compound treatment 1.225544E7 -915000.0 -0.51 1.323184E7 -304000.0 -0.17 1.116728E7 -601127.619047601 -0.352967025466884 -0.5994 -0.9271 2019463 PK04_130137 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCOCCOCCOCCOCC2)c3coc4ccccc4c3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G22 compound treatment 1.21564E7 -1010000.0 -0.57 1.10424E7 -2490000.0 -1.4 9381320.0 -2387087.6190476 -1.40163783816651 -1.9485 -0.9441 3080280 PK04_130138 COc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G23 compound treatment 1.193648E7 -1230000.0 -0.69 1.239256E7 -1140000.0 -0.64 1.095396E7 -814447.619047601 -0.478223166570315 -1.0479 -0.9887 3221297 PK04_130139 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 G24 compound treatment 1.115892E7 -2010000.0 -1.13 9304840.0 -4230000.0 -2.38 8673440.0 -3094967.6190476 -1.81728717795788 -3.0766 -0.9609 3211912 PK04_130140 C[C@H](CCO)[C@@H](O)c1ccc(O)c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H01 compound treatment 1.29166E7 -254000.0 -0.14 1.328984E7 -246000.0 -0.14 1.049992E7 -1268487.6190476 -0.744824039937096 -0.5923 -0.7684 3052931 PK04_130141 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H02 compound treatment 1.335228E7 182000.0 0.1 1.33246E7 -212000.0 -0.12 1.110744E7 -660967.619047601 -0.388103569080372 -0.2338 -0.5585 3221300 PK04_130142 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H03 mock treatment 1.286556E7 -305000.0 -0.17 1.291676E7 -619000.0 -0.35 1.15048E7 -263607.619047601 -0.15478376676995 -0.3895 -0.9315 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H04 mock treatment 1.2784E7 -386000.0 -0.22 1.316608E7 -370000.0 -0.21 1.190164E7 133232.380952399 0.0782307046133498 -0.2004 -0.6447 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H05 compound treatment 1.256152E7 -609000.0 -0.34 1.286412E7 -672000.0 -0.38 1.154456E7 -223847.619047601 -0.131437694342271 -0.4917 -0.9338 3176330 PK04_130143 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H06 compound treatment 1.299712E7 -173000.0 -0.1 1.3504E7 -32100.0 -0.02 1.136072E7 -407687.619047601 -0.239383920577293 -0.2048 -0.7907 3221301 PK04_130144 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H07 compound treatment 1.343844E7 268000.0 0.15 1.395368E7 418000.0 0.24 1.189684E7 128432.380952399 0.0754122652860646 0.2662 0.9206 3176685 PK04_130145 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H08 compound treatment 1.413144E7 961000.0 0.54 1.4169E7 633000.0 0.36 1.168548E7 -82927.6190476008 -0.0486930130920582 0.4892 0.7543 3221302 PK04_130146 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H09 compound treatment 1.357564E7 405000.0 0.23 1.407368E7 538000.0 0.3 1.184768E7 79272.3809523992 0.0465467491757859 0.333 0.8729 3052879 PK04_130147 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H10 compound treatment 1.420976E7 1040000.0 0.58 1.38256E7 289000.0 0.16 1.209876E7 330352.380952399 0.193974612987193 0.5431 0.8534 3221303 PK04_130148 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H11 compound treatment 1.419408E7 1020000.0 0.58 1.442856E7 892000.0 0.5 1.269412E7 925712.380952399 0.543555037548128 0.9358 0.9985 3176775 PK04_130149 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H12 compound treatment 1.314892E7 -21400.0 -0.01 1.300996E7 -526000.0 -0.3 1.18504E7 81992.3809523992 0.0481438647945808 -0.1501 -0.5 3221305 PK04_130150 COc1cc2c3N(C(=O)[C@]42O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)O)C(C)(C)C=C(C)c3c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H13 compound treatment 1.464384E7 1470000.0 0.83 1.616292E7 2630000.0 1.48 1.191284E7 144432.380952399 0.0848070630436818 1.3805 0.8137 3052783 PK04_130151 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H14 compound treatment 1.323356E7 63200.0 0.04 1.363556E7 99400.0 0.06 1.114176E7 -626647.619047601 -0.367951727890284 -0.1596 -0.4269 3221307 PK04_130152 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(CC=C)c5ccccc54)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H15 compound treatment 1.409552E7 925000.0 0.52 1.311712E7 -419000.0 -0.24 1.200468E7 236272.380952399 0.138733202172404 0.2439 0.4154 3176626 PK04_130153 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H16 compound treatment 1.304468E7 -126000.0 -0.07 1.207276E7 -1460000.0 -0.82 1.032464E7 -1443767.6190476 -0.847744049371792 -1.0058 -0.8494 3221308 PK04_130154 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccccc32)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H17 compound treatment 1.374236E7 572000.0 0.32 1.334844E7 -188000.0 -0.11 1.147512E7 -293287.619047601 -0.17221111661033 0.0251 0.0661 3176501 PK04_130155 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H18 compound treatment 1.340236E7 232000.0 0.13 1.273332E7 -803000.0 -0.45 1.189088E7 122472.380952399 0.0719127031213522 -0.1441 -0.303 3221309 PK04_130156 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H19 mock treatment 1.300368E7 -167000.0 -0.09 1.325612E7 -280000.0 -0.16 1.159292E7 -175487.619047601 -0.103041918119873 -0.2045 -0.9726 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H20 mock treatment 1.361152E7 441000.0 0.25 1.440916E7 873000.0 0.49 1.149236E7 -276047.619047601 -0.162088222026497 0.3332 0.5808 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H21 compound treatment 1.254548E7 -625000.0 -0.35 1.346648E7 -69600.0 -0.04 1.082664E7 -941767.619047601 -0.552982269726554 -0.5445 -0.8299 3052741 PK04_130157 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H22 compound treatment 1.197492E7 -1200000.0 -0.67 1.153516E7 -2000000.0 -1.13 9860000.0 -1908407.6190476 -1.12056897625299 -1.6849 -0.9768 3221310 PK04_130158 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H23 compound treatment 1.206992E7 -1100000.0 -0.62 1.232852E7 -1210000.0 -0.68 1.129224E7 -476167.619047601 -0.279593654979894 -0.9107 -0.9483 3176203 PK04_130159 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 H24 compound treatment 1.147716E7 -1690000.0 -0.95 1.114392E7 -2390000.0 -1.35 1.029956E7 -1468847.6190476 -0.862470394856857 -1.8245 -0.9806 3221312 PK04_130160 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I01 compound treatment 9859840.0 -3310000.0 -1.86 1.06582E7 -2880000.0 -1.62 9459640.0 -2308767.6190476 -1.35565030314297 -2.7915 -0.9919 3221313 PK04_130161 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccc(Cl)cc2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I02 compound treatment 1.21274E7 -1040000.0 -0.59 1.211876E7 -1420000.0 -0.8 1.127872E7 -489687.619047601 -0.287532259085081 -0.9649 -0.9361 3080209 PK04_130162 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I03 compound treatment 1.125912E7 -1910000.0 -1.07 1.175248E7 -1780000.0 -1.0 1.070732E7 -1061087.6190476 -0.623043974003984 -1.5592 -0.9767 3221314 PK04_130163 Nc1ccccc1NC(=O)C2=C[C@@H](C[C@H](OCCCCO)O2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I04 compound treatment 1.300884E7 -161000.0 -0.09 1.438276E7 847000.0 0.48 1.114208E7 -626327.619047601 -0.367763831935131 0.0105 0.0172 3069956 PK04_130164 CO[C@@H](C=C)[C@@H](O)c1ccc(OC)c(O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I05 mock treatment 1.265288E7 -517000.0 -0.29 1.298472E7 -551000.0 -0.31 1.105144E7 -716967.619047601 -0.420985361232033 -0.5901 -0.9861 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I06 mock treatment 1.573784E7 2570000.0 1.44 1.327664E7 -259000.0 -0.15 1.134472E7 -423687.619047601 -0.24877871833491 0.6046 0.4111 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I07 compound treatment 1.221672E7 -954000.0 -0.54 1.3628E7 91900.0 0.05 1.163876E7 -129647.619047601 -0.0761258225443003 -0.3233 -0.5949 3221316 PK04_130165 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cccs2)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I08 compound treatment 1.373328E7 563000.0 0.32 1.399612E7 460000.0 0.26 1.195908E7 190672.380952399 0.111958028563195 0.3967 0.9361 3211693 PK04_130166 CO[C@H](CCO)[C@H](O)c1ccc(O)c(F)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I09 compound treatment 1.356516E7 395000.0 0.22 1.388368E7 348000.0 0.2 1.1289E7 -479407.619047601 -0.281496101525812 0.0785 0.1922 2019335 PK04_130167 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I10 compound treatment 1.32012E7 30900.0 0.02 1.236792E7 -1170000.0 -0.66 9558200.0 -2210207.6190476 -1.29777834895605 -1.1189 -0.769 3080278 PK04_130168 CSc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I11 compound treatment 1.405672E7 886000.0 0.5 1.417696E7 641000.0 0.36 1.04318E7 -1336607.6190476 -0.784822391390151 0.0426 0.0427 3221318 PK04_130169 COc1cc2c[n+](Cc3cc4OCOc4cc3Br)ccc2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I12 compound treatment 1.383296E7 663000.0 0.37 1.271884E7 -817000.0 -0.46 1.247E7 701592.380952399 0.411957407958306 0.1871 0.2595 3211911 PK04_130170 COc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I13 compound treatment 1.517652E7 2010000.0 1.13 1.506184E7 1530000.0 0.86 1.155052E7 -217887.619047601 -0.127938132177559 1.0726 0.754 3221319 PK04_130171 COc1cc2c[n+](Cc3sc4ccccc4c3Cl)ccc2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I14 compound treatment 1.378116E7 611000.0 0.34 1.3716E7 180000.0 0.1 1.151324E7 -255167.619047601 -0.149828010952807 0.17 0.4384 3080208 PK04_130172 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I15 compound treatment 1.352772E7 357000.0 0.2 1.285084E7 -685000.0 -0.39 1.14468E7 -321607.619047601 -0.188839908641312 -0.2158 -0.4553 3221320 PK04_130173 COc1cc2c[n+](Cc3ccc(o3)[N+](=O)[O-])ccc2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I16 compound treatment 1.345468E7 284000.0 0.16 1.325132E7 -285000.0 -0.16 1.123024E7 -538167.619047601 -0.315998496290661 -0.1828 -0.4703 3080223 PK04_130174 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I17 compound treatment 1.342388E7 254000.0 0.14 1.338644E7 -150000.0 -0.08 1.14902E7 -278207.619047601 -0.163356519723776 -0.0607 -0.2612 3221321 PK04_130175 COc1cc2c[n+](Cc3cccc(OC(F)(F)F)c3)ccc2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I18 compound treatment 1.046348E7 -2710000.0 -1.52 9291760.0 -4240000.0 -2.39 7645080.0 -4123327.6190476 -2.42111431683433 -3.655 -0.981 3080282 PK04_130176 CSc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I19 compound treatment 1.241816E7 -752000.0 -0.42 1.306372E7 -472000.0 -0.27 1.143812E7 -330287.619047601 -0.19393658642482 -0.5094 -0.9512 3221322 PK04_130177 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3cccs3)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I20 compound treatment 1.294428E7 -226000.0 -0.13 1.31866E7 -350000.0 -0.2 1.129056E7 -477847.619047601 -0.280580108744444 -0.3489 -0.9547 3211594 PK04_130178 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I21 mock treatment 1.281792E7 -352000.0 -0.2 1.306628E7 -470000.0 -0.26 1.0668E7 -1100407.6190476 -0.646131689493328 -0.64 -0.882 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I22 mock treatment 1.241488E7 -755000.0 -0.42 1.335616E7 -180000.0 -0.1 1.1147E7 -621407.619047601 -0.364874931624664 -0.5141 -0.904 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I23 compound treatment 1.328796E7 118000.0 0.07 1.22584E7 -1280000.0 -0.72 1.011784E7 -1650567.6190476 -0.969171810388994 -0.9367 -0.7749 3221324 PK04_130179 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cc3OCOc3cc2Br)c4cccs4)CCCO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 I24 compound treatment 1.109212E7 -2080000.0 -1.17 1.040456E7 -3130000.0 -1.76 1.037348E7 -1394927.6190476 -0.819066429216666 -2.1646 -0.9547 3211811 PK04_130180 CSc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J01 compound treatment 1.232156E7 -849000.0 -0.48 1.246376E7 -1070000.0 -0.6 1.055232E7 -1216087.6190476 -0.7140560772809 -1.036 -0.9871 3176788 PK04_130181 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J02 compound treatment 1.114848E7 -2020000.0 -1.14 1.13896E7 -2150000.0 -1.21 1.004744E7 -1720967.6190476 -1.01050892052251 -1.9367 -0.9973 3221326 PK04_130182 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCOC5=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J03 compound treatment 1.273064E7 -440000.0 -0.25 1.299152E7 -545000.0 -0.31 1.101312E7 -755287.619047601 -0.443485901861526 -0.5756 -0.9707 3176789 PK04_130183 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J04 compound treatment 1.271224E7 -458000.0 -0.26 1.322364E7 -312000.0 -0.18 1.141656E7 -351847.619047601 -0.206596076403209 -0.3694 -0.9878 3221328 PK04_130184 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N(C=O)c4ccccc4)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J05 mock treatment 1.209856E7 -1070000.0 -0.6 1.515888E7 1620000.0 0.91 1.170024E7 -68167.6190476008 -0.0400263121606563 0.1567 0.1432 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J06 mock treatment 1.414964E7 979000.0 0.55 1.38702E7 334000.0 0.19 1.156328E7 -205127.619047601 -0.120445780965859 0.3566 0.6007 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J07 compound treatment 1.296636E7 -204000.0 -0.11 1.416156E7 625000.0 0.35 1.148536E7 -283047.619047601 -0.166198446045455 0.0412 0.1014 3052827 PK04_130185 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J08 compound treatment 9568320.0 -3600000.0 -2.02 1.014316E7 -3390000.0 -1.91 8689240.0 -3079167.6190476 -1.80800981517224 -3.3146 -0.9989 3221330 PK04_130186 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4CCOC4=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J09 compound treatment 1.355084E7 381000.0 0.21 1.514352E7 1610000.0 0.9 1.201032E7 241912.380952399 0.142044868381964 0.7278 0.7738 3052794 PK04_130187 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J10 compound treatment 1.42824E7 1110000.0 0.62 1.39582E7 422000.0 0.24 1.239648E7 628072.380952399 0.368788312262055 0.7107 0.9311 3221332 PK04_130188 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5cccc6cccc4c56)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J11 compound treatment 1.455564E7 1390000.0 0.78 1.381248E7 276000.0 0.16 1.175772E7 -10687.6190476008 -0.00627550121641664 0.5354 0.6747 3176437 PK04_130189 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J12 compound treatment 1.428332E7 1110000.0 0.63 1.233248E7 -1200000.0 -0.68 9016640.0 -2751767.6190476 -1.615768766057 -0.9631 -0.5177 3221334 PK04_130190 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCOC4=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J13 compound treatment 1.356848E7 398000.0 0.22 1.5479E7 1940000.0 1.09 1.212248E7 354072.380952399 0.207902400662861 0.8806 0.7755 3176038 PK04_130191 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J14 compound treatment 9886320.0 -3280000.0 -1.84 9549640.0 -3990000.0 -2.24 6966840.0 -4801567.6190476 -2.81935979377973 -3.9883 -0.9852 3221335 PK04_130192 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCC4=O)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J15 compound treatment 1.324088E7 70600.0 0.04 1.362848E7 92400.0 0.05 1.146776E7 -300647.619047601 -0.176532723578834 -0.049 -0.2604 3052796 PK04_130193 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J16 compound treatment 1.256052E7 -610000.0 -0.34 1.283476E7 -701000.0 -0.39 9268440.0 -2499967.6190476 -1.4679181363465 -1.2732 -0.8171 3221337 PK04_130194 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCCCC5=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J17 compound treatment 1.495604E7 1790000.0 1.0 1.393652E7 400000.0 0.23 1.1522E7 -246407.619047601 -0.144684359180512 0.6257 0.6027 3176331 PK04_130195 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J18 compound treatment 1.20286E7 -1140000.0 -0.64 1.004036E7 -3500000.0 -1.97 8383760.0 -3384647.6190476 -1.98737999135954 -2.6538 -0.9249 3221339 PK04_130196 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCC5=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J19 compound treatment 1.440536E7 1240000.0 0.69 1.347204E7 -64100.0 -0.04 1.172364E7 -44767.6190476008 -0.0262864204401412 0.3645 0.5244 3176671 PK04_130197 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J20 compound treatment 1.2963E7 -207000.0 -0.12 1.19568E7 -1580000.0 -0.89 9812360.0 -1956047.6190476 -1.1485419865763 -1.2436 -0.8535 3221341 PK04_130198 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4C(=O)c5ccccc5Oc6ccccc46)c7ccccc72)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J21 mock treatment 1.301592E7 -154000.0 -0.09 1.302964E7 -506000.0 -0.29 1.114796E7 -620447.619047601 -0.364311243759207 -0.425 -0.903 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J22 mock treatment 1.244984E7 -720000.0 -0.4 1.252036E7 -1020000.0 -0.57 1.171752E7 -50887.6190476008 -0.0298799305824298 -0.581 -0.8287 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J23 compound treatment 1.198736E7 -1180000.0 -0.66 1.2349E7 -1190000.0 -0.67 1.096672E7 -801687.619047601 -0.470730815358615 -1.0412 -0.9884 3176271 PK04_130199 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 J24 compound treatment 1.072852E7 -2440000.0 -1.37 7929920.0 -5610000.0 -3.16 6253360.0 -5515047.6190476 -3.23829731278627 -4.4835 -0.9489 3221343 PK04_130200 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5ccccc5Oc6ccccc46)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K01 compound treatment 1.060876E7 -2560000.0 -1.44 1.100996E7 -2530000.0 -1.42 8603680.0 -3164727.6190476 -1.8582484961811 -2.7245 -0.9919 3221345 PK04_130201 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3cccs3)c4ccc(CO)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K02 compound treatment 9640720.0 -3530000.0 -1.98 9720040.0 -3820000.0 -2.15 9606040.0 -2162367.6190476 -1.26968790366077 -3.1179 -0.9783 3211905 PK04_130202 C[C@H](CCO)[C@H](O)c1ccc(O)c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K03 compound treatment 7795640.0 -5370000.0 -3.02 9676360.0 -3860000.0 -2.17 8825200.0 -2943207.6190476 -1.72817752122689 -3.9951 -0.9741 3221347 PK04_130203 COc1ccc(CN2CCc3cc(OC)c(O)cc3C2C#Cc4ccccc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K04 compound treatment 1.2141E7 -1030000.0 -0.58 1.294832E7 -588000.0 -0.33 1.085368E7 -914727.619047601 -0.537105061516181 -0.8349 -0.9757 3211691 PK04_130204 CSc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K05 compound treatment 1.120748E7 -1960000.0 -1.1 1.097256E7 -2560000.0 -1.44 9662200.0 -2106207.6190476 -1.23671216353154 -2.1837 -0.9939 3221348 PK04_130205 COc1cc2CCN(C)C(C#Cc3ccccc3)c2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K06 compound treatment 1.210656E7 -1060000.0 -0.6 1.191708E7 -1620000.0 -0.91 1.077012E7 -998287.619047601 -0.586169392805336 -1.2096 -0.9775 3211813 PK04_130206 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K07 mock treatment 1.152104E7 -1650000.0 -0.93 1.2852E7 -684000.0 -0.39 1.152228E7 -246127.619047601 -0.144519950219753 -0.8406 -0.8294 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K08 mock treatment 1.291948E7 -251000.0 -0.14 1.3716E7 180000.0 0.1 1.114764E7 -620767.619047601 -0.364499139714359 -0.2333 -0.578 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K09 compound treatment 1.19788E7 -1190000.0 -0.67 1.239308E7 -1140000.0 -0.64 1.043804E7 -1330367.6190476 -0.781158420264681 -1.2089 -0.9964 3221349 PK04_130207 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C#Cc4ccccc4)c2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K10 compound treatment 3440960.0 -9730000.0 -5.46 7575520.0 -5960000.0 -3.36 6717960.0 -5050447.6190476 -2.96549587289946 -6.8044 -0.9631 3211817 PK04_130208 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K11 compound treatment 1.20524E7 -1120000.0 -0.63 1.199212E7 -1540000.0 -0.87 1.049844E7 -1269967.6190476 -0.745693058729676 -1.2949 -0.9914 3221350 PK04_130209 COCC#CC1N(Cc2ccc(OC)cc2)CCc3cc(OC)c(O)cc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K12 compound treatment 1.229952E7 -871000.0 -0.49 1.162876E7 -1910000.0 -1.07 9617720.0 -2150687.6190476 -1.26282970129771 -1.6314 -0.944 3080279 PK04_130210 C[C@@H](CCO)[C@@H](O)c1ccc(O)c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K13 compound treatment 1.218168E7 -989000.0 -0.56 1.237332E7 -1160000.0 -0.65 1.080936E7 -959047.619047601 -0.56312865130478 -1.0236 -0.9971 3221351 PK04_130211 COCC#CC1N(C)CCc2cc(OC)c(O)cc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K14 compound treatment 1.35196E7 349000.0 0.2 1.250888E7 -1030000.0 -0.58 1.17262E7 -42207.6190476008 -0.0247832527989225 -0.2349 -0.3844 3080188 PK04_130212 CO[C@H](CCO)[C@H](O)c1ccc(OC)c(O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K15 mock treatment 1.291456E7 -256000.0 -0.14 1.341568E7 -120000.0 -0.07 1.139164E7 -376767.619047601 -0.221228473910697 -0.2498 -0.9172 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K16 mock treatment 1.286772E7 -303000.0 -0.17 1.328188E7 -254000.0 -0.14 1.17342E7 -34207.6190476008 -0.0200858539201139 -0.1924 -0.8622 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K17 compound treatment 1.223772E7 -933000.0 -0.52 1.237844E7 -1160000.0 -0.65 1.080376E7 -964647.619047601 -0.566416830519946 -1.0057 -0.9958 3221353 PK04_130213 COCC#CC1N(Cc2ccc(o2)[N+](=O)[O-])CCc3cc(OC)c(O)cc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K18 compound treatment 1.267184E7 -498000.0 -0.28 1.300896E7 -527000.0 -0.3 1.186164E7 93232.3809523992 0.0547437102193069 -0.3014 -0.7321 3080221 PK04_130214 CO[C@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K19 compound treatment 1.16774E7 -1490000.0 -0.84 1.41274E7 591000.0 0.33 1.00472E7 -1721207.6190476 -1.01064984248887 -0.8755 -0.6462 3221354 PK04_130215 COc1ccc(CN2CCc3cc(OC)c(O)cc3C2C#C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K20 compound treatment 1.217724E7 -993000.0 -0.56 1.275184E7 -784000.0 -0.44 1.082892E7 -939487.619047601 -0.551643511046093 -0.8954 -0.9947 3211696 PK04_130216 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K21 compound treatment 1.106556E7 -2100000.0 -1.18 1.061E7 -2930000.0 -1.65 9012080.0 -2756327.6190476 -1.61844628341792 -2.5679 -0.9899 3221356 PK04_130217 COc1cc2CCN(C)C(C#C)c2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K22 compound treatment 1.0921E7 -2250000.0 -1.26 1.0628E7 -2910000.0 -1.64 9026440.0 -2741967.6190476 -1.61001445243046 -2.6041 -0.9937 3211816 PK04_130218 COc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K23 mock treatment 1.260216E7 -568000.0 -0.32 1.225316E7 -1280000.0 -0.72 1.03242E7 -1444207.6190476 -0.848002406310127 -1.0908 -0.9414 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 K24 mock treatment 1.128788E7 -1880000.0 -1.06 1.118432E7 -2350000.0 -1.32 1.043124E7 -1337167.6190476 -0.785151209311668 -1.8281 -0.979 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L01 compound treatment 1.12246E7 -1950000.0 -1.09 1.22284E7 -1310000.0 -0.74 1.10336E7 -734807.619047601 -0.431460560731776 -1.3051 -0.9413 3176382 PK04_130219 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L02 compound treatment 1.370092E7 531000.0 0.3 1.411732E7 581000.0 0.33 1.1072E7 -696407.619047601 -0.408913046113494 0.1249 0.2072 3221357 PK04_130220 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCCCC4=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L03 compound treatment 1.259652E7 -574000.0 -0.32 1.352736E7 -8770.0 0.0 1.13234E7 -445007.619047601 -0.261297286346935 -0.3398 -0.8189 3176383 PK04_130221 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L04 compound treatment 1.058924E7 -2580000.0 -1.45 1.18102E7 -1730000.0 -0.97 9275880.0 -2492527.6190476 -1.4635495553892 -2.2429 -0.9848 3221359 PK04_130222 C[C@H](O)C(=O)Nc1ccc2N(CC=C)C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L05 compound treatment 1.288416E7 -286000.0 -0.16 1.30678E7 -468000.0 -0.26 1.12398E7 -528607.619047601 -0.310385104630484 -0.4242 -0.9689 3052642 PK04_130223 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L06 compound treatment 1.095836E7 -2210000.0 -1.24 1.193408E7 -1600000.0 -0.9 1.076804E7 -1000367.6190476 -0.587390716513827 -1.5771 -0.9595 3221361 PK04_130224 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4CCC4=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L07 mock treatment 1.271872E7 -452000.0 -0.25 1.329868E7 -237000.0 -0.13 1.156024E7 -208167.619047601 -0.122230792539807 -0.2942 -0.9439 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L08 mock treatment 1.347416E7 304000.0 0.17 1.4046E7 510000.0 0.29 1.193816E7 169752.380952399 0.099674330495111 0.3218 0.9234 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L09 compound treatment 1.369248E7 522000.0 0.29 1.357976E7 43600.0 0.02 1.238048E7 612072.380952399 0.359393514504438 0.391 0.8417 3176673 PK04_130225 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L10 compound treatment 9460240.0 -3710000.0 -2.08 1.133324E7 -2200000.0 -1.24 9477640.0 -2290767.6190476 -1.34508115566565 -2.6956 -0.9721 3221363 PK04_130226 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)c5ccccc35)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L11 compound treatment 1.351596E7 346000.0 0.19 1.355496E7 18800.0 0.01 1.089572E7 -872687.619047601 -0.512420230408042 -0.1776 -0.3241 3052529 PK04_130227 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L12 compound treatment 1.45164E7 1350000.0 0.76 1.343028E7 -106000.0 -0.06 1.14652E7 -303207.619047601 -0.178035891220053 0.2993 0.3842 3221365 PK04_130228 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N(C=O)c4ccccc4)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L13 compound treatment 1.366708E7 497000.0 0.28 1.46998E7 1160000.0 0.66 1.374328E7 1974872.3809524 1.15959541350948 1.2088 0.8883 3052693 PK04_130229 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L14 compound treatment 1.254072E7 -630000.0 -0.35 1.227952E7 -1260000.0 -0.71 9520240.0 -2248167.6190476 -1.320067506636 -1.3747 -0.8933 3221366 PK04_130230 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L15 mock treatment 1.353008E7 360000.0 0.2 1.45756E7 1040000.0 0.59 1.181828E7 49872.3809523992 0.0292838082961643 0.4714 0.7606 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L16 mock treatment 1.398672E7 816000.0 0.46 1.368068E7 145000.0 0.08 1.16762E7 -92207.6190476008 -0.0541419957914761 0.2805 0.5982 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L17 compound treatment 1.341424E7 244000.0 0.14 1.333308E7 -203000.0 -0.11 1.166956E7 -98847.6190476008 -0.0580408368608872 -0.0204 -0.1087 3176205 PK04_130231 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L18 compound treatment 1.266128E7 -509000.0 -0.29 1.274604E7 -790000.0 -0.44 1.026708E7 -1501327.6190476 -0.88154183430482 -0.9308 -0.9055 3221368 PK04_130232 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCOC4=O)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L19 compound treatment 1.366168E7 491000.0 0.28 1.312228E7 -414000.0 -0.23 1.183592E7 67512.3809523992 0.0396415728239373 0.0477 0.1314 3176125 PK04_130233 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L20 compound treatment 1.094044E7 -2230000.0 -1.25 1.169196E7 -1840000.0 -1.04 8105880.0 -3662527.6190476 -2.15054414141496 -2.5641 -0.9509 3221370 PK04_130234 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)F)c3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L21 compound treatment 1.227844E7 -892000.0 -0.5 1.244928E7 -1090000.0 -0.61 1.065464E7 -1113767.6190476 -0.653976345620938 -1.02 -0.994 3052877 PK04_130235 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L22 compound treatment 1.11434E7 -2030000.0 -1.14 1.0326E7 -3210000.0 -1.81 7158760.0 -4609647.6190476 -2.70666919467711 -3.2633 -0.9465 3221372 PK04_130236 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(NC(=O)C)cc32)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L23 mock treatment 1.196792E7 -1200000.0 -0.68 1.297988E7 -556000.0 -0.31 1.114368E7 -624727.619047601 -0.36682435215937 -0.7825 -0.9429 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 L24 mock treatment 1.186248E7 -1310000.0 -0.73 1.151892E7 -2020000.0 -1.14 1.102508E7 -743327.619047601 -0.436463290537707 -1.3317 -0.9371 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M01 compound treatment 9430000.0 -3740000.0 -2.1 1.011676E7 -3420000.0 -1.92 9362880.0 -2405527.6190476 -1.41246534258216 -3.1397 -0.9873 3221374 PK04_130237 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C#C)c2cc1O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M02 compound treatment 1.122412E7 -1950000.0 -1.09 1.171084E7 -1830000.0 -1.03 1.076168E7 -1006727.6190476 -0.591125148622479 -1.5656 -0.9709 3211810 PK04_130238 C[C@@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M03 compound treatment 1.211784E7 -1050000.0 -0.59 1.224184E7 -1290000.0 -0.73 1.082136E7 -947047.619047601 -0.556082552986567 -1.083 -0.993 3221375 PK04_130239 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M04 compound treatment 1.101828E7 -2150000.0 -1.21 1.184316E7 -1690000.0 -0.95 1.005828E7 -1710127.6190476 -1.00414394504172 -1.8278 -0.9946 3080224 PK04_130240 COc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M05 compound treatment 1.205336E7 -1120000.0 -0.63 1.248456E7 -1050000.0 -0.59 1.061104E7 -1157367.6190476 -0.679577169510445 -1.0963 -0.9984 3221376 PK04_130241 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M06 compound treatment 7966040.0 -5200000.0 -2.92 8799960.0 -4740000.0 -2.67 7711560.0 -4056847.6190476 -2.38207893215143 -4.6022 -0.9966 3211820 PK04_130242 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M07 compound treatment 1.216668E7 -1000000.0 -0.56 1.261836E7 -918000.0 -0.52 1.183492E7 66512.3809523992 0.0390543979640862 -0.6012 -0.7852 3221377 PK04_130243 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M08 compound treatment 1.276664E7 -404000.0 -0.23 1.317484E7 -361000.0 -0.2 1.168668E7 -81727.6190476008 -0.0479884032602369 -0.276 -0.8952 3211694 PK04_130244 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M09 mock treatment 1.342592E7 256000.0 0.14 1.405052E7 514000.0 0.29 1.146504E7 -303367.619047601 -0.178129839197629 0.1472 0.3989 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M10 mock treatment 1.35176E7 347000.0 0.2 1.390024E7 364000.0 0.2 1.129268E7 -475727.619047601 -0.27933529804156 0.0697 0.1752 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M11 compound treatment 1.31942E7 23900.0 0.01 1.389452E7 358000.0 0.2 1.133096E7 -437447.619047601 -0.256858244406461 -0.0241 -0.0737 3221378 PK04_130245 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M12 compound treatment 1.348112E7 311000.0 0.17 1.358896E7 52800.0 0.03 1.188524E7 116832.380952399 0.0686010369117922 0.1576 0.8297 3080189 PK04_130246 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M13 mock treatment 1.338768E7 217000.0 0.12 1.401072E7 475000.0 0.27 1.281236E7 1043952.3809524 0.612982592976919 0.5786 0.8513 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M14 mock treatment 1.344512E7 275000.0 0.15 1.362684E7 90700.0 0.05 1.196712E7 198712.380952399 0.116678914436398 0.186 0.9293 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M15 compound treatment 1.242364E7 -747000.0 -0.42 1.287472E7 -661000.0 -0.37 1.096864E7 -799767.619047601 -0.469603439627701 -0.7282 -0.9956 3221379 PK04_130247 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M16 compound treatment 1.345396E7 284000.0 0.16 1.344008E7 -96000.0 -0.05 1.207868E7 310272.380952399 0.182184141801384 0.1659 0.6692 3211679 PK04_130248 CO[C@@H](CCO)[C@@H](O)c1ccc(OC)c(O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M17 compound treatment 1.247484E7 -695000.0 -0.39 1.299116E7 -545000.0 -0.31 1.0878E7 -890407.619047601 -0.522824968924603 -0.7045 -0.9769 3221380 PK04_130249 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M18 compound treatment 1.228328E7 -887000.0 -0.5 1.326728E7 -269000.0 -0.15 1.12734E7 -495007.619047601 -0.290656029339488 -0.5428 -0.9103 3211808 PK04_130250 C[C@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M19 mock treatment 1.249684E7 -673000.0 -0.38 1.3105E7 -431000.0 -0.24 1.124572E7 -522687.619047601 -0.306909029460166 -0.5357 -0.9843 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M20 compound treatment 1.017616E7 -2990000.0 -1.68 9498560.0 -4040000.0 -2.27 8434080.0 -3334327.6190476 -1.95783335241184 -3.4135 -0.9926 3080271 PK04_130251 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M21 mock treatment 1.20348E7 -1140000.0 -0.64 1.264252E7 -894000.0 -0.5 1.128564E7 -482767.619047601 -0.283469009054911 -0.8223 -0.9558 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M22 compound treatment 1.102496E7 -2150000.0 -1.21 1.062708E7 -2910000.0 -1.64 9626440.0 -2141967.6190476 -1.25770953651981 -2.3673 -0.9902 3211910 PK04_130252 C[C@@H](CCO)[C@H](O)c1ccc(O)c2ccccc12 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M23 mock treatment 1.162576E7 -1540000.0 -0.87 1.14642E7 -2070000.0 -1.17 1.070824E7 -1060167.6190476 -0.622503773132921 -1.5337 -0.9699 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 M24 compound treatment 9433600.0 -3740000.0 -2.1 8064280.0 -5470000.0 -3.08 7988200.0 -3780207.6190476 -2.21964287892223 -4.2716 -0.9847 3211692 PK04_130253 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c(F)c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N01 compound treatment 1.279968E7 -371000.0 -0.21 1.271408E7 -822000.0 -0.46 1.166468E7 -103727.619047601 -0.0609062501769605 -0.4225 -0.8268 3176433 PK04_130254 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N02 compound treatment 345440.0 -1.28E7 -7.2 513120.0 -1.3E7 -7.33 614240.0 -1.11541676190476E7 -6.54944680846965 -12.1727 -0.9988 3221382 PK04_130255 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCCCC5=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N03 compound treatment 1.437964E7 1210000.0 0.68 1.423796E7 702000.0 0.4 1.288708E7 1118672.3809524 0.656856298504991 0.9995 0.9759 3175967 PK04_130256 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N04 compound treatment 1.40296E7 859000.0 0.48 1.693256E7 3400000.0 1.91 1.47564E7 2987992.3809524 1.7544740075218 2.3954 0.9076 3221383 PK04_130257 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5C(=O)c6ccccc6Oc7ccccc57)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N05 compound treatment 1.36592E7 489000.0 0.27 1.293208E7 -604000.0 -0.34 1.257936E7 810952.380952399 0.476170850631619 0.2371 0.3669 3052653 PK04_130258 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N06 compound treatment 1.314348E7 -26800.0 -0.02 1.350996E7 -26200.0 -0.01 1.248848E7 720072.380952399 0.422808399368353 0.2269 0.536 3221385 PK04_130259 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5cccc6cccc4c56)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N07 compound treatment 1.47326E7 1560000.0 0.88 1.411196E7 576000.0 0.32 1.61268E7 4358392.3809524 2.55913843546171 2.1713 0.7969 3052758 PK04_130260 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCN(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N08 compound treatment 1.136724E7 -1800000.0 -1.01 1.187308E7 -1660000.0 -0.94 1.126264E7 -505767.619047601 -0.296974030831486 -1.2967 -0.9191 3221386 PK04_130261 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccc(cc3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N09 mock treatment 1.530064E7 2130000.0 1.2 1.420856E7 672000.0 0.38 1.297708E7 1208672.3809524 0.709702035891588 1.3191 0.9149 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N10 mock treatment 1.5009E7 1840000.0 1.03 1.436412E7 828000.0 0.47 1.250172E7 733312.380952399 0.430582594512782 1.1139 0.919 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N11 compound treatment 1.402752E7 857000.0 0.48 1.392704E7 391000.0 0.22 1.293656E7 1168152.3809524 0.685909710570422 0.801 0.9245 3176332 PK04_130262 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N12 compound treatment 1.475772E7 1590000.0 0.89 1.771364E7 4180000.0 2.35 1.38698E7 2101392.3809524 1.23388477677784 2.5848 0.9227 3221388 PK04_130263 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N13 mock treatment 1.456392E7 1390000.0 0.78 1.622104E7 2680000.0 1.51 1.262696E7 858552.380952399 0.50412037396053 1.6156 0.9101 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N14 mock treatment 1.83946E7 5220000.0 2.93 1.46592E7 1120000.0 0.63 1.357904E7 1810632.3809524 1.06315781452754 2.673 0.8394 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N15 compound treatment 1.42476E7 1080000.0 0.61 1.452156E7 985000.0 0.55 1.20368E7 268392.380952399 0.157593258670821 0.7606 0.91 3176440 PK04_130264 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N16 compound treatment 1.420712E7 1040000.0 0.58 1.392084E7 385000.0 0.22 1.198364E7 215232.380952399 0.126379043121138 0.5342 0.8426 3221389 PK04_130265 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N4C(=O)c5cccc6cccc4c56)c7ccccc72)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N17 compound treatment 1.333708E7 167000.0 0.09 1.367596E7 140000.0 0.08 1.287096E7 1102552.3809524 0.647391039764192 0.4733 0.7184 3174818 PK04_130266 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N18 compound treatment 1.093564E7 -2230000.0 -1.26 1.028116E7 -3250000.0 -1.83 8688440.0 -3079967.6190476 -1.80847955506012 -2.8267 -0.9869 3221391 PK04_130267 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCOC5=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N19 compound treatment 1.325428E7 84000.0 0.05 1.397516E7 439000.0 0.25 1.17718E7 3392.38095239922 0.00199192081028646 0.1711 0.6799 3052539 PK04_130268 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N20 compound treatment 1.285808E7 -312000.0 -0.18 8927920.0 -4610000.0 -2.59 8605040.0 -3163367.6190476 -1.8574499383717 -2.6713 -0.836 3221392 PK04_130269 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N(C=O)c5ccccc5)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N21 compound treatment 1.552816E7 2360000.0 1.32 1.336964E7 -166000.0 -0.09 1.159576E7 -172647.619047601 -0.101374341517896 0.652 0.4896 3052582 PK04_130270 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N22 compound treatment 1.189568E7 -1270000.0 -0.72 1.146012E7 -2080000.0 -1.17 1.25176E7 749192.380952399 0.439906931287217 -0.8341 -0.5795 3221394 PK04_130271 C[C@H](O)C(=O)Nc1ccc(CN2C(=O)[C@@]3(O[C@@H](CCO)[C@@H]([C@H]3C)[Si](C)(C)F)c4ccccc24)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N23 compound treatment 1.20788E7 -1090000.0 -0.61 1.15416E7 -1990000.0 -1.12 1.081444E7 -953967.619047601 -0.560145803016737 -1.3256 -0.9492 3052791 PK04_130272 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 N24 compound treatment 8735360.0 -4430000.0 -2.49 7670880.0 -5870000.0 -3.3 8028320.0 -3740087.6190476 -2.19608542354501 -4.6123 -0.9849 3221396 PK04_130273 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(NC(=O)C)c3)c4ccccc42)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O01 mock treatment 1.117144E7 -2000000.0 -1.12 1.14318E7 -2100000.0 -1.18 9471240.0 -2297167.6190476 -1.3488390747687 -2.1109 -0.9969 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O02 compound treatment 9641640.0 -3530000.0 -1.98 1.008184E7 -3450000.0 -1.94 9998240.0 -1770167.6190476 -1.03939792362718 -2.867 -0.9671 3211913 PK04_130274 CSc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O03 mock treatment 1.251804E7 -652000.0 -0.37 1.355972E7 23600.0 0.01 1.194472E7 176312.380952399 0.103526197575734 -0.1441 -0.3782 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O04 mock treatment 1.309852E7 -71800.0 -0.04 1.395804E7 422000.0 0.24 1.158556E7 -182847.619047601 -0.107363525088377 0.0518 0.1966 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O05 mock treatment 1.530276E7 2130000.0 1.2 1.555052E7 2010000.0 1.13 1.153784E7 -230567.619047601 -0.135383509400471 1.268 0.7662 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O06 mock treatment 1.358788E7 418000.0 0.23 1.386516E7 329000.0 0.19 1.431712E7 2548712.3809524 1.49653983508642 1.1064 0.725 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O07 mock treatment 1.789404E7 4720000.0 2.65 1.472396E7 1190000.0 0.67 1.610336E7 4334952.3809524 2.5453750567468 3.3875 0.9064 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O08 mock treatment 1.32764E7 106000.0 0.06 1.938612E7 5850000.0 3.29 1.178948E7 21072.3809523992 0.0123731723324534 1.9428 0.5899 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O09 mock treatment 1.48828E7 1710000.0 0.96 1.56658E7 2130000.0 1.2 1.186812E7 99712.3809523992 0.0585486033111418 1.2813 0.833 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O10 mock treatment 1.278668E7 -384000.0 -0.22 1.390236E7 366000.0 0.21 1.516796E7 3399552.3809524 1.99613169284211 1.1471 0.5683 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O11 mock treatment 1.402248E7 852000.0 0.48 1.377108E7 235000.0 0.13 1.425048E7 2482072.3809524 1.45741050242594 1.1941 0.7756 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O12 mock treatment 1.689548E7 3730000.0 2.09 2.043684E7 6900000.0 3.88 1.323904E7 1470632.3809524 0.863518362178175 3.9493 0.8784 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O13 mock treatment 1.424672E7 1080000.0 0.6 1.495076E7 1410000.0 0.8 1.277928E7 1010872.3809524 0.593558848613046 1.1515 0.9903 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O14 mock treatment 1.452988E7 1360000.0 0.76 1.331316E7 -223000.0 -0.13 1.70542E7 5285792.3809524 3.10368440048759 2.1603 0.6754 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O15 mock treatment 1.291128E7 -259000.0 -0.15 1.401664E7 481000.0 0.27 1.124876E7 -519647.619047601 -0.305124017886219 -0.104 -0.2402 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O16 mock treatment 1.331888E7 149000.0 0.08 1.33004E7 -236000.0 -0.13 1.29696E7 1201192.3809524 0.705309967939902 0.3788 0.5242 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O17 mock treatment 1.254536E7 -625000.0 -0.35 1.319704E7 -339000.0 -0.19 1.184088E7 72472.3809523992 0.0425539601287986 -0.2883 -0.7175 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O18 mock treatment 1.272536E7 -445000.0 -0.25 1.33248E7 -211000.0 -0.12 1.166644E7 -101967.619047601 -0.0598728224236226 -0.2475 -0.8741 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O19 mock treatment 1.292668E7 -244000.0 -0.14 1.352436E7 -11800.0 -0.01 1.178644E7 18032.3809523992 0.0105881607585062 -0.0767 -0.5583 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O20 mock treatment 1.241056E7 -760000.0 -0.43 1.254024E7 -996000.0 -0.56 1.541728E7 3648872.3809524 2.14252612890018 0.6669 0.2957 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O21 mock treatment 1.276724E7 -403000.0 -0.23 1.21914E7 -1340000.0 -0.76 1.110216E7 -666247.619047601 -0.391203852340386 -0.7936 -0.9001 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O22 mock treatment 1.172008E7 -1450000.0 -0.81 1.197844E7 -1560000.0 -0.88 1.065352E7 -1114887.6190476 -0.654633981463971 -1.3545 -0.9929 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O23 mock treatment 1.260088E7 -569000.0 -0.32 1.267936E7 -857000.0 -0.48 1.049168E7 -1276727.6190476 -0.749662360782269 -0.8959 -0.946 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 O24 mock treatment 9826160.0 -3340000.0 -1.88 9839080.0 -3700000.0 -2.08 9451440.0 -2316967.6190476 -1.36046513699375 -3.0715 -0.9857 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P01 compound treatment 8991000.0 -4180000.0 -2.35 8873400.0 -4660000.0 -2.62 5970800.0 -5797607.6190476 -3.40420944118579 -4.8361 -0.9874 3175838 PK04_130275 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P02 compound treatment 8229400.0 -4940000.0 -2.78 7994080.0 -5540000.0 -3.12 7083920.0 -4684487.6190476 -2.75061336118836 -4.9915 -0.9983 3221398 PK04_130276 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccc(cc3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P03 compound treatment 1.171084E7 -1460000.0 -0.82 1.23464E7 -1190000.0 -0.67 1.226576E7 497352.380952399 0.292032814582323 -0.6913 -0.6296 3052740 PK04_130277 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P04 compound treatment 8374040.0 -4800000.0 -2.69 9382280.0 -4150000.0 -2.34 8622560.0 -3145847.6190476 -1.84716263482711 -3.9718 -0.9887 3221399 PK04_130278 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(NC(=O)C)c3)c4ccccc42)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P05 compound treatment 1.190592E7 -1260000.0 -0.71 1.255756E7 -979000.0 -0.55 1.136184E7 -406567.619047601 -0.238726284734259 -0.8659 -0.9311 3176784 PK04_130279 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P06 compound treatment 1.217836E7 -992000.0 -0.56 1.23256E7 -1210000.0 -0.68 1.146364E7 -304767.619047601 -0.17895188400142 -0.8184 -0.9112 3221400 PK04_130280 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5C(=O)c6ccccc6Oc7ccccc57)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P07 compound treatment 1.251032E7 -660000.0 -0.37 1.25714E7 -965000.0 -0.54 1.100132E7 -767087.619047601 -0.450414565207768 -0.7876 -0.9882 3052752 PK04_130281 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P08 compound treatment 1.077172E7 -2400000.0 -1.35 1.049048E7 -3050000.0 -1.71 1.051912E7 -1249287.6190476 -0.733550282627956 -2.1912 -0.9525 3221401 PK04_130282 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCC5=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P09 compound treatment 1.476148E7 1590000.0 0.89 1.216268E7 -1370000.0 -0.77 1.12938E7 -474607.619047601 -0.278677662198526 -0.0913 -0.0752 3052788 PK04_130283 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P10 compound treatment 1.226984E7 -900000.0 -0.51 1.118116E7 -2350000.0 -1.33 1.142504E7 -343367.619047601 -0.201616833591672 -1.1738 -0.819 3221402 PK04_130284 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P11 mock treatment 1.326132E7 91000.0 0.05 1.395036E7 414000.0 0.23 1.220368E7 435272.380952399 0.255580999282768 0.3117 0.8913 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P12 mock treatment 1.276364E7 -407000.0 -0.23 1.32288E7 -307000.0 -0.17 1.1191E7 -577407.619047601 -0.339039237791217 -0.4275 -0.9631 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P13 compound treatment 1.3582E7 412000.0 0.23 1.365168E7 116000.0 0.07 1.206492E7 296512.380952399 0.174104615729833 0.2716 0.9154 3052846 PK04_130285 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P14 compound treatment 8251600.0 -4920000.0 -2.76 8169200.0 -5370000.0 -3.02 9287880.0 -2480527.6190476 -1.45650345707099 -4.1802 -0.962 3221404 PK04_130286 C[C@H](O)C(=O)Nc1cccc(CN2C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c4ccccc24)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P15 compound treatment 1.223116E7 -939000.0 -0.53 1.377964E7 244000.0 0.14 1.121488E7 -553527.619047601 -0.325017502137973 -0.4131 -0.6509 3052836 PK04_130287 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P16 compound treatment 1.09678E7 -2200000.0 -1.24 1.166204E7 -1870000.0 -1.05 1.071552E7 -1052887.6190476 -0.618229140153205 -1.6803 -0.966 3221406 PK04_130288 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P17 compound treatment 1.190612E7 -1260000.0 -0.71 1.216492E7 -1370000.0 -0.77 1.08784E7 -890007.619047601 -0.522590098980662 -1.1573 -0.9877 3176730 PK04_130289 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P18 compound treatment 1.100972E7 -2160000.0 -1.21 1.145E7 -2090000.0 -1.17 9957480.0 -1810927.6190476 -1.06333117091471 -1.9926 -0.9985 3221407 PK04_130290 C[C@H](O)C(=O)Nc1ccc(CN2C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c4ccccc24)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P19 compound treatment 1.138556E7 -1780000.0 -1.0 1.140904E7 -2130000.0 -1.2 1.098964E7 -778767.619047601 -0.457272767570829 -1.5341 -0.9428 3052799 PK04_130291 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P20 compound treatment 1.098536E7 -2180000.0 -1.23 6459680.0 -7080000.0 -3.98 7547720.0 -4220687.6190476 -2.47828166118943 -4.4392 -0.9154 3221408 PK04_130292 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)c5ccccc35)cc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P21 compound treatment 1.1337E7 -1830000.0 -1.03 1.253864E7 -997000.0 -0.56 1.159904E7 -169367.619047601 -0.0994484079775849 -0.9761 -0.8293 3176730 PK04_130293 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P22 compound treatment 6453000.0 -6720000.0 -3.77 4648640.0 -8890000.0 -5.0 3989640.0 -7778767.6190476 -4.56749678652834 -7.7038 -0.9935 3221410 PK04_130294 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCC4=O)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P23 compound treatment 1.02902E7 -2880000.0 -1.62 1.01532E7 -3380000.0 -1.9 8344760.0 -3423647.6190476 -2.01027981089374 -3.1941 -0.996 3176786 PK04_130295 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2130 P24 compound treatment 1561560.0 -1.16E7 -6.52 1128080.0 -1.24E7 -6.98 747440.0 -1.10209676190476E7 -6.47123511713749 -11.5333 -0.9994 3221411 PK04_130296 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4C(=O)COc5ccccc45)c6ccccc62)[Si](C)(C)F 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A01 compound treatment 8025480.0 -5840000.0 -3.28 7735840.0 -5280000.0 -2.97 7318080.0 -5337408.8888889 -3.13399231630121 -5.4196 -0.9992 3561840 PK04_181001 CC(C)(C)N(CC=C)C(=O)C1N(Cc2ccccc2)C(=O)C3C(C4OC13C=C4)C(=O)O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A02 compound treatment 8910160.0 -4960000.0 -2.78 8879920.0 -4140000.0 -2.33 9880760.0 -2774728.8888889 -1.62925104645806 -3.8922 -0.9784 3561841 PK04_181002 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A03 compound treatment 1.042112E7 -3440000.0 -1.93 9678560.0 -3340000.0 -1.88 1.044728E7 -2208208.8888889 -1.29660474485523 -2.9506 -0.9859 3561843 PK04_181003 OC1CCC(CC1)N2C(C(=O)N(CC=C)c3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A04 compound treatment 1.13212E7 -2540000.0 -1.43 1.076104E7 -2260000.0 -1.27 1.094796E7 -1707528.8888889 -1.002618036025 -2.1371 -0.99 2065615 PK04_181004 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A05 compound treatment 1.198432E7 -1880000.0 -1.06 1.074728E7 -2270000.0 -1.28 1.092588E7 -1729608.8888889 -1.01558285693051 -1.9341 -0.9947 3561844 PK04_181005 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccco4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A06 compound treatment 1.09146E7 -2950000.0 -1.66 9719360.0 -3300000.0 -1.86 8197840.0 -4457648.8888889 -2.61741936159863 -3.5399 -0.9801 3561845 PK04_181006 CCCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)c5ccccc5Cl)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A07 compound treatment 1.138464E7 -2480000.0 -1.39 9677560.0 -3340000.0 -1.88 1.064396E7 -2011528.8888889 -1.18111919341972 -2.5718 -0.9812 3561847 PK04_181007 Cc1cccc2OC(CC(=O)c12)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A08 compound treatment 1.203836E7 -1830000.0 -1.03 1.00222E7 -2990000.0 -1.69 1.0883E7 -1772488.8888889 -1.04076091492092 -2.1667 -0.9711 3561848 PK04_181008 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A09 compound treatment 1.089236E7 -2970000.0 -1.67 9804760.0 -3210000.0 -1.81 1.003492E7 -2620568.8888889 -1.53873217006342 -2.8965 -0.9978 3561850 PK04_181009 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A10 compound treatment 1.113956E7 -2730000.0 -1.53 1.11688E7 -1850000.0 -1.04 1.063908E7 -2016408.8888889 -1.1839846067358 -2.1682 -0.9867 3561851 PK04_181010 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A11 compound treatment 1.068376E7 -3180000.0 -1.79 1.152304E7 -1490000.0 -0.84 1.097944E7 -1676048.8888889 -0.984133771436886 -2.0855 -0.9451 3561853 PK04_181011 Brc1ccc(CN(C(C(=O)NCc2ccccc2)c3ccco3)C(=O)Cc4ccccc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A12 compound treatment 1.23738E7 -1490000.0 -0.84 1.131064E7 -1710000.0 -0.96 1.137804E7 -1277448.8888889 -0.750085872300248 -1.4714 -0.9949 3561854 PK04_181012 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A13 mock treatment 1.305552E7 -810000.0 -0.46 1.177712E7 -1240000.0 -0.7 1.16564E7 -999088.888888899 -0.586639878312104 -1.0043 -0.9857 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A14 mock treatment 1.235152E7 -1510000.0 -0.85 1.165704E7 -1360000.0 -0.77 1.179828E7 -857208.888888899 -0.503331509196433 -1.2236 -0.9788 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A15 compound treatment 7071960.0 -6790000.0 -3.82 9678760.0 -3340000.0 -1.88 7948280.0 -4707208.8888889 -2.76395471962306 -4.8838 -0.9628 3561850 PK04_181013 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A16 compound treatment 1.235424E7 -1510000.0 -0.85 1.144892E7 -1570000.0 -0.88 1.095424E7 -1701248.8888889 -0.998930577905133 -1.5765 -0.9975 3561856 PK04_181014 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A17 compound treatment 7382480.0 -6480000.0 -3.64 8932040.0 -4080000.0 -2.3 9755680.0 -2899808.8888889 -1.70269487792824 -4.413 -0.9529 3561858 PK04_181015 COc1ccc(CNC(=O)OCC2c3ccccc3-c4ccccc24)cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A18 compound treatment 1.160044E7 -2270000.0 -1.27 1.107584E7 -1940000.0 -1.09 1.171716E7 -938328.888888899 -0.550963133827552 -1.6835 -0.9537 3561856 PK04_181016 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A19 compound treatment 1.178472E7 -2080000.0 -1.17 1.173384E7 -1280000.0 -0.72 1.132792E7 -1327568.8888889 -0.779515076275984 -1.5419 -0.9761 3561859 PK04_181017 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4cc(OC)cc(OC)c4)C(=O)C13)C(=O)NCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A20 compound treatment 1.122408E7 -2640000.0 -1.48 1.06264E7 -2390000.0 -1.35 1.101016E7 -1645328.8888889 -0.966095759742261 -2.1913 -0.9854 3561860 PK04_181018 COc1ccc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A21 compound treatment 8690280.0 -5180000.0 -2.91 8562960.0 -4450000.0 -2.51 7806520.0 -4848968.8888889 -2.84719262775555 -4.7697 -0.998 3561861 PK04_181019 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4ccccc4)C(=O)C13)C(=O)NCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A22 compound treatment 1.054196E7 -3320000.0 -1.87 9917440.0 -3100000.0 -1.74 9538080.0 -3117408.8888889 -1.83046412743183 -3.142 -0.9996 3561862 PK04_181020 COc1cc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)ccc1O[SiH](C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A23 compound treatment 9712480.0 -4150000.0 -2.33 9317760.0 -3700000.0 -2.08 8954200.0 -3701288.8888889 -2.17330378460167 -3.8038 -0.9989 3561864 PK04_181021 O=C(Cc1ccccc1)OC(C(=O)NCc2ccccc2)c3ccco3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 A24 compound treatment 7669600.0 -6200000.0 -3.48 7412440.0 -5600000.0 -3.15 6677440.0 -5978048.8888889 -3.5101600185162 -5.8573 -0.9989 3561865 PK04_181022 COc1cc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)ccc1O[SiH](C(C)C)C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B01 compound treatment 1.18856E7 -1980000.0 -1.11 1.136124E7 -1660000.0 -0.93 1.133628E7 -1319208.8888889 -0.774606294447629 -1.6274 -0.9894 3561867 PK04_181023 OC(CC=C)c1cccc(c1)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B02 compound treatment 1.143164E7 -2430000.0 -1.37 1.049684E7 -2520000.0 -1.42 1.185676E7 -798728.888888899 -0.468993523392343 -1.8791 -0.9279 1008566 PK04_181024 Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B03 compound treatment 1.231488E7 -1550000.0 -0.87 1.20638E7 -953000.0 -0.54 1.1469E7 -1186488.8888889 -0.696676447048195 -1.2149 -0.9816 3561868 PK04_181025 CC(C)(C)OC(=O)OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B04 compound treatment 1.1554E7 -2310000.0 -1.3 1.073664E7 -2280000.0 -1.28 1.100948E7 -1646008.8888889 -0.96649503864696 -2.0487 -0.9917 3561869 PK04_181026 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)[Se]c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B05 compound treatment 1.326E7 -606000.0 -0.34 1.25936E7 -423000.0 -0.24 1.296076E7 305271.111111101 0.179247521883242 -0.2305 -0.5095 3561870 PK04_181027 OC(CC1CO1)c2ccc(cc2)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B06 compound treatment 1.223316E7 -1630000.0 -0.92 1.349588E7 479000.0 0.27 1.28942E7 238711.111111101 0.140165163211555 -0.2928 -0.3031 3561871 PK04_181028 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B07 compound treatment 1.36632E7 -202000.0 -0.11 1.227476E7 -742000.0 -0.42 1.243316E7 -222328.888888899 -0.130545934174184 -0.3822 -0.8452 3561872 PK04_181029 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccc(cc4)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B08 compound treatment 1.269856E7 -1170000.0 -0.66 1.23804E7 -637000.0 -0.36 1.172364E7 -931848.888888899 -0.547158240735718 -0.9012 -0.9733 3561873 PK04_181030 CC(C)CC1CC(=O)C=C(Cl)N1C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B09 compound treatment 1.391168E7 46100.0 0.03 1.304528E7 28300.0 0.02 1.320664E7 551151.111111101 0.323622076423424 0.211 0.6491 3561874 PK04_181031 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B10 compound treatment 1.417004E7 304000.0 0.17 1.32156E7 199000.0 0.11 1.323972E7 584231.111111101 0.343045820787297 0.3613 0.905 3561875 PK04_181032 COC(=O)C1=C(Cl)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B11 compound treatment 1.313156E7 -734000.0 -0.41 1.269032E7 -327000.0 -0.18 1.208928E7 -566208.888888899 -0.332463624979771 -0.5361 -0.9563 3561876 PK04_181033 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B12 compound treatment 1.212464E7 -1740000.0 -0.98 1.153952E7 -1480000.0 -0.83 1.055784E7 -2097648.8888889 -1.2316866923501 -1.7559 -0.987 3561877 PK04_181034 COC(=O)C1=C(OC)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B13 mock treatment 1.463052E7 765000.0 0.43 1.334364E7 327000.0 0.18 1.3294E7 638511.111111101 0.374917672180013 0.5707 0.9525 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B14 mock treatment 1.419784E7 332000.0 0.19 1.397644E7 959000.0 0.54 1.32468E7 591311.111111101 0.347203018795043 0.62 0.9273 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B15 compound treatment 8289080.0 -5580000.0 -3.13 7954360.0 -5060000.0 -2.85 8070120.0 -4585368.8888889 -2.69241333469881 -5.0082 -0.998 3561878 PK04_181035 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B16 compound treatment 674160.0 -1.32E7 -7.41 993160.0 -1.2E7 -6.77 383080.0 -1.22724088888889E7 -7.2060499693684 -12.3459 -0.9993 3561879 PK04_181036 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B17 compound treatment 1.345528E7 -410000.0 -0.23 1.307988E7 62900.0 0.04 1.196628E7 -689208.888888899 -0.404686132741453 -0.3463 -0.7414 3561880 PK04_181037 OC(CC1CO1)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B18 compound treatment 1.290208E7 -964000.0 -0.54 1.356072E7 544000.0 0.31 1.256108E7 -94408.8888888992 -0.0554345261020349 -0.1677 -0.2687 3561881 PK04_181038 CC(C)(C)OC(=O)NCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B19 compound treatment 1.409672E7 231000.0 0.13 1.352612E7 509000.0 0.29 1.296132E7 305831.111111101 0.179576339804759 0.3441 0.9498 3561882 PK04_181039 CN(CC(O)CC(O)c1ccccc1)Cc2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B20 compound treatment 1.241752E7 -1450000.0 -0.81 1.208376E7 -933000.0 -0.53 1.158312E7 -1072368.8888889 -0.62966805204199 -1.1364 -0.9839 3561883 PK04_181040 COc1ccc(CN(C(=C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B21 compound treatment 1.303912E7 -826000.0 -0.46 1.214312E7 -874000.0 -0.49 1.179548E7 -860008.888888899 -0.504975598804016 -0.8436 -0.9994 3561884 PK04_181041 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B22 compound treatment 501800.0 -1.34E7 -7.51 544000.0 -1.25E7 -7.02 450680.0 -1.22048088888889E7 -7.16635694884247 -12.5249 -0.9996 3561885 PK04_181042 COc1ccc(CNS(=O)(=O)c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-])c(OC)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B23 compound treatment 1.215292E7 -1710000.0 -0.96 1.090624E7 -2110000.0 -1.19 1.0375E7 -2280488.8888889 -1.33904574372527 -2.0145 -0.9912 3561886 PK04_181043 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccncc3)CC(O2)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 B24 compound treatment 5187480.0 -8680000.0 -4.87 5335480.0 -7680000.0 -4.32 3022040.0 -9633448.8888889 -5.65651900121581 -8.5765 -0.994 3561887 PK04_181044 Brc1ccc(cc1)S(=O)(=O)N2C[C@H]2C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C01 compound treatment 1.164708E7 -2220000.0 -1.25 1.114384E7 -1870000.0 -1.05 1.035784E7 -2297648.8888889 -1.34912166432031 -2.1071 -0.995 3561889 PK04_181045 O=C(Cc1ccccc1)N2CC(=O)Oc3ccccc23 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C02 compound treatment 1.28518E7 -1010000.0 -0.57 1.152764E7 -1490000.0 -0.84 1.156648E7 -1089008.8888889 -0.639438641709912 -1.182 -0.9864 3561890 PK04_181046 CCCCCNC(=O)[C@H]1N(C(=O)[C@@H]2[C@H](C3OC12C=C3)C(=O)OCC)c4ccccc4Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C03 compound treatment 1.12164E7 -2650000.0 -1.49 1.119452E7 -1820000.0 -1.03 1.069252E7 -1962968.8888889 -1.15260598222536 -2.1168 -0.9875 3561892 PK04_181047 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C04 compound treatment 1.424904E7 383000.0 0.22 1.270616E7 -311000.0 -0.17 1.271276E7 57271.1111111008 0.0336281566401758 0.0427 0.1529 2065568 PK04_181048 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C05 compound treatment 6468120.0 -7400000.0 -4.16 9448320.0 -3570000.0 -2.01 1088520.0 -1.15669688888889E7 -6.79183333623506 -7.48 -0.9109 3561893 PK04_181049 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)OCC=C)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C06 compound treatment 1.413004E7 264000.0 0.15 1.381096E7 794000.0 0.45 1.307456E7 419071.111111101 0.246068020934294 0.4859 0.9143 2065566 PK04_181050 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C07 compound treatment 1.361344E7 -252000.0 -0.14 1.2867E7 -150000.0 -0.08 1.272192E7 66431.1111111008 0.0390066783564117 -0.108 -0.6374 3561894 PK04_181051 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)N(CC=C)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C08 compound treatment 1.368304E7 -183000.0 -0.1 1.33964E7 379000.0 0.21 1.28064E7 150911.111111101 0.0886112105166303 0.1153 0.4557 2065605 PK04_181052 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2cccs2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C09 compound treatment 1.183412E7 -2030000.0 -1.14 1.234296E7 -674000.0 -0.38 1.231336E7 -342128.888888899 -0.200889482384343 -0.9938 -0.8152 3561895 PK04_181053 O=C(Cc1ccccc1)OC(COCc2ccccc2)C(=O)NCc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C10 compound treatment 1.329376E7 -572000.0 -0.32 1.318992E7 173000.0 0.1 1.2066E7 -589488.888888899 -0.346133055717104 -0.3291 -0.6825 2065603 PK04_181054 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3cccs3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C11 mock treatment 1.468032E7 815000.0 0.46 1.36194E7 602000.0 0.34 1.357008E7 914591.111111101 0.537024907487698 0.77 0.9837 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C12 mock treatment 1.492132E7 1060000.0 0.59 1.52034E7 2190000.0 1.23 1.310816E7 452671.111111101 0.26579709622529 1.2064 0.8668 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C13 compound treatment 1.391208E7 46500.0 0.03 1.281184E7 -205000.0 -0.12 1.382492E7 1169431.1111111 0.686660548772145 0.3448 0.4949 3561896 PK04_181055 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)NCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C14 compound treatment 1.487596E7 1010000.0 0.57 1.390696E7 890000.0 0.5 1.371752E7 1062031.1111111 0.62359796882414 0.9769 0.9961 2065601 PK04_181056 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3cccs3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C15 mock treatment 1.436156E7 496000.0 0.28 1.43674E7 1350000.0 0.76 1.273108E7 75591.1111111008 0.0443852000726475 0.6253 0.7712 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C16 mock treatment 1.402952E7 164000.0 0.09 1.35236E7 507000.0 0.29 1.31248E7 469311.111111101 0.275567685893212 0.3769 0.9258 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C17 compound treatment 1.03244E7 -3540000.0 -1.99 1.055012E7 -2470000.0 -1.39 1.101872E7 -1636768.8888889 -0.961069542941936 -2.505 -0.96 3561897 PK04_181057 OC1CCC(CC1)N2C(C(=O)NCc3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C18 compound treatment 1.339784E7 -468000.0 -0.26 1.28786E7 -138000.0 -0.08 1.252808E7 -127408.888888899 -0.0748112964771203 -0.2399 -0.8444 3057099 PK04_181058 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3ccco3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C19 compound treatment 1.193264E7 -1930000.0 -1.09 1.224448E7 -773000.0 -0.43 1.158936E7 -1066128.8888889 -0.62600408091652 -1.2393 -0.9342 3561892 PK04_181059 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C20 compound treatment 1.316844E7 -697000.0 -0.39 1.264388E7 -373000.0 -0.21 1.18194E7 -836088.888888899 -0.490930376156379 -0.6308 -0.9526 3057100 PK04_181060 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3ccco3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C21 compound treatment 1.308856E7 -777000.0 -0.44 1.313132E7 114000.0 0.06 1.193936E7 -716128.888888899 -0.420492879968644 -0.4576 -0.7508 3561898 PK04_181061 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=C[C@]42O[C@@H]5/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]4C1=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C22 compound treatment 1.228692E7 -1580000.0 -0.89 1.187904E7 -1140000.0 -0.64 1.143128E7 -1224208.8888889 -0.718824682761777 -1.2968 -0.9907 3176076 PK04_181062 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C23 compound treatment 1.227156E7 -1590000.0 -0.9 1.151424E7 -1500000.0 -0.85 1.163408E7 -1021408.8888889 -0.59974562118398 -1.3516 -0.9866 3561899 PK04_181063 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 C24 compound treatment 1.078984E7 -3080000.0 -1.73 1.029484E7 -2720000.0 -1.53 9901360.0 -2754128.8888889 -1.61715524434513 -2.8158 -0.9988 2065566 PK04_181064 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D01 compound treatment 1.292264E7 -943000.0 -0.53 9520600.0 -3500000.0 -1.97 1.210984E7 -545648.888888899 -0.320391309861233 -1.6271 -0.7886 3561900 PK04_181065 COCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D02 compound treatment 1.191604E7 -1950000.0 -1.1 1.18398E7 -1180000.0 -0.66 1.212712E7 -528368.888888899 -0.310244928283007 -1.1939 -0.9066 3561901 PK04_181066 COc1cc(OC)c(CNS(=O)(=O)c2ccc(Br)cc2)c(OC)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D03 compound treatment 1.377852E7 -87100.0 -0.05 1.346304E7 446000.0 0.25 1.302512E7 369631.111111101 0.217038095863257 0.242 0.7215 3561902 PK04_181067 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D04 compound treatment 1.311224E7 -753000.0 -0.42 1.371284E7 696000.0 0.39 1.262384E7 -31648.8888888992 -0.0185834318977816 -0.0289 -0.0501 3561903 PK04_181068 COc1ccc(CN(C(COC(=O)c2cccc(OC)c2O)C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D05 compound treatment 7593680.0 -6270000.0 -3.52 9579640.0 -3440000.0 -1.93 7425480.0 -5230008.8888889 -3.07092973635321 -4.924 -0.9735 3215593 PK04_181069 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)NO)cc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D06 compound treatment 1.13636E7 -2500000.0 -1.41 1.200724E7 -1010000.0 -0.57 1.170108E7 -954408.888888899 -0.560404905573958 -1.4631 -0.9053 3561904 PK04_181070 COC(=O)C1CC=C(CC1C(=O)OC)N(Cc2ccc(OC)cc2)S(=O)(=O)c3ccc(Br)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D07 compound treatment 1.482924E7 964000.0 0.54 1.345228E7 435000.0 0.25 1.425896E7 1603471.1111111 0.941517924941905 0.9976 0.896 3561905 PK04_181071 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CN(C)Cc3ccccc3)CC(O2)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D08 compound treatment 1.321716E7 -648000.0 -0.36 1.325612E7 239000.0 0.13 1.212276E7 -532728.888888899 -0.312805010671957 -0.3132 -0.6281 3561906 PK04_181072 COc1ccc(CN([C@H](COC(=O)c2ccc(cc2)[N+](=O)[O-])C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D09 compound treatment 1.423164E7 366000.0 0.21 1.337008E7 353000.0 0.2 1.311028E7 454791.111111101 0.267041906928174 0.3876 0.9907 3561908 PK04_181073 OC(CSc1nc2ccccc2o1)CC(O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D10 compound treatment 1.281996E7 -1050000.0 -0.59 1.209104E7 -926000.0 -0.52 1.200096E7 -654528.888888899 -0.384322908601818 -0.8619 -0.9859 3561909 PK04_181074 Brc1ccc(cc1)N2C(CN(C2=O)S(=O)(=O)c3ccc(Br)cc3)C=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D11 mock treatment 1.47814E7 916000.0 0.51 1.411544E7 1100000.0 0.62 1.355708E7 901591.111111101 0.529391634309634 0.9596 0.9966 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D12 mock treatment 1.49738E7 1110000.0 0.62 1.429328E7 1280000.0 0.72 1.451688E7 1861391.1111111 1.09296206479469 1.4052 0.9701 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D13 compound treatment 1.515568E7 1290000.0 0.72 1.472304E7 1710000.0 0.96 1.341624E7 760751.111111101 0.446693927048209 1.2307 0.959 3561910 PK04_181075 COC(=O)CCCCCCC(=O)NOCc1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D14 compound treatment 1.353948E7 -326000.0 -0.18 1.31448E7 128000.0 0.07 1.231976E7 -335728.888888899 -0.197131563281296 -0.178 -0.6391 3561911 PK04_181076 COc1ccc(CN([C@H](CI)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D15 mock treatment 1.458544E7 720000.0 0.4 1.389276E7 876000.0 0.49 1.28604E7 204911.111111101 0.120318652948588 0.5875 0.9055 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D16 mock treatment 1.454212E7 677000.0 0.38 1.315E7 133000.0 0.07 1.3207E7 551511.111111101 0.32383345937297 0.4496 0.8905 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D17 compound treatment 1.402368E7 158000.0 0.09 1.362592E7 609000.0 0.34 1.296272E7 307231.111111101 0.18039838460855 0.3533 0.8891 3561913 PK04_181077 OC(=O)CCCCCCC(=O)NOCc1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D18 compound treatment 1.136544E7 -2500000.0 -1.4 1.1078E7 -1940000.0 -1.09 1.084648E7 -1809008.8888889 -1.06220454080268 -2.0542 -0.9916 3561914 PK04_181078 COc1ccc(CN(C2=CCC3C(C2)C(=O)N(C)C3=O)S(=O)(=O)c4ccc(Br)cc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D19 compound treatment 1.364968E7 -216000.0 -0.12 1.412584E7 1110000.0 0.62 1.258412E7 -71368.8888888992 -0.0419060173310662 0.2662 0.4177 3561915 PK04_181079 OCc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D20 compound treatment 1.244908E7 -1420000.0 -0.8 1.196632E7 -1050000.0 -0.59 1.091032E7 -1745168.8888889 -1.02471929774979 -1.3924 -0.9766 3561916 PK04_181080 COCCCN(CC(O)CO)C[C@]1(O)CCC2[C@]1(C)CCC3[C@@]4(C)CC[C@H](O)C[C@@]54C=C[C@]23C(=C5)C(=O)c6ccc(OC)cc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D21 compound treatment 1.334404E7 -522000.0 -0.29 1.274828E7 -269000.0 -0.15 1.236184E7 -293648.888888899 -0.172423245178763 -0.356 -0.9569 3561917 PK04_181081 O=Cc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D22 compound treatment 1.187248E7 -1990000.0 -1.12 1.128496E7 -1730000.0 -0.97 1.143044E7 -1225048.8888889 -0.719317909644052 -1.6245 -0.9848 3561918 PK04_181082 COCCCN(CC(O)CO)C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D23 compound treatment 1.213152E7 -1730000.0 -0.97 1.230556E7 -711000.0 -0.4 1.193664E7 -718848.888888899 -0.422089995587439 -1.0372 -0.9142 3561919 PK04_181083 OC(CN=[N+]=[N-])CC(O)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 D24 compound treatment 1.101676E7 -2850000.0 -1.6 1.09188E7 -2100000.0 -1.18 1.098316E7 -1672328.8888889 -0.98194948095824 -2.1727 -0.9796 3561920 PK04_181084 COCCCN(C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C)C(=O)O[C@H]5C[C@@H](C)CC[C@@H]5C(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E01 mock treatment 1.194128E7 -1920000.0 -1.08 1.090068E7 -2120000.0 -1.19 1.256028E7 -95208.8888888992 -0.0559042659899158 -1.3441 -0.8351 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E02 mock treatment 1.38516E7 -14000.0 -0.01 1.19848E7 -1030000.0 -0.58 1.287256E7 217071.111111101 0.127458699244377 -0.2664 -0.4478 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E03 compound treatment 1.300104E7 -865000.0 -0.49 1.1908E7 -1110000.0 -0.62 1.1976E7 -679488.888888899 -0.398978793103701 -0.8711 -0.9834 3561899 PK04_181085 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E04 compound treatment 1.239988E7 -1470000.0 -0.82 1.18702E7 -1150000.0 -0.65 1.236848E7 -287008.888888899 -0.168524404109352 -0.9453 -0.8921 2065568 PK04_181086 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E05 compound treatment 1.37702E7 -95400.0 -0.05 1.25524E7 -465000.0 -0.26 1.213028E7 -525208.888888899 -0.308389455725877 -0.36 -0.8825 3561899 PK04_181087 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E06 compound treatment 1.359668E7 -269000.0 -0.15 1.281112E7 -206000.0 -0.12 1.295416E7 298671.111111101 0.175372167808225 -0.0529 -0.2042 2065570 PK04_181088 O=C(NCc1ccccc1)C(COCc2ccccc2)OC(=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E07 compound treatment 1.377544E7 -90200.0 -0.05 1.241904E7 -598000.0 -0.34 1.176772E7 -887768.888888899 -0.521275572913482 -0.5245 -0.8425 3561899 PK04_181089 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E08 compound treatment 1.295736E7 -908000.0 -0.51 1.283584E7 -181000.0 -0.1 1.266116E7 5671.11111110076 0.00332993387186045 -0.3515 -0.6756 2065572 PK04_181090 COc1ccc(NC(=O)C(COCc2ccccc2)OC(=O)c3ccccc3)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E09 mock treatment 1.410656E7 241000.0 0.14 1.381232E7 795000.0 0.45 1.312288E7 467391.111111101 0.274440310162298 0.4951 0.9129 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E10 mock treatment 1.501544E7 1150000.0 0.65 1.35062E7 489000.0 0.28 1.286412E7 208631.111111101 0.122502943427234 0.6026 0.8455 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E11 compound treatment 1.096184E7 -2900000.0 -1.63 1.09958E7 -2020000.0 -1.14 1.036116E7 -2294328.8888889 -1.34717224378561 -2.3763 -0.9893 3561921 PK04_181091 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E12 compound treatment 1.419532E7 330000.0 0.19 1.394228E7 925000.0 0.52 1.304464E7 389151.111111101 0.22849974912755 0.5396 0.902 2065574 PK04_181092 CC(C)(C)NC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E13 compound treatment 1.506948E7 1200000.0 0.68 1.479928E7 1780000.0 1.0 1.107872E7 -1576768.8888889 -0.925839051350872 0.4351 0.2856 3561922 PK04_181093 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(Cc4ccc(OC)cc4)C(=O)[C@@H]13)C(=O)NCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E14 compound treatment 1.380436E7 -61200.0 -0.03 1.350976E7 493000.0 0.28 1.29622E7 306711.111111101 0.180093053681427 0.2443 0.7346 2065576 PK04_181094 CCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E15 compound treatment 1.431392E7 448000.0 0.25 1.374612E7 729000.0 0.41 1.286872E7 213231.111111101 0.125203947782549 0.4546 0.9138 3561841 PK04_181095 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E16 compound treatment 1.342088E7 -445000.0 -0.25 1.426696E7 1250000.0 0.7 1.228504E7 -370448.888888899 -0.217518274415325 0.1364 0.1754 2065599 PK04_181096 CCCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E17 mock treatment 1.474204E7 876000.0 0.49 1.34392E7 422000.0 0.24 1.226568E7 -389808.888888899 -0.228885979702042 0.2893 0.4881 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E18 mock treatment 1.416696E7 301000.0 0.17 1.252328E7 -494000.0 -0.28 1.22222E7 -433288.888888899 -0.254416342608367 -0.2096 -0.5075 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E19 compound treatment 1.399672E7 131000.0 0.07 1.421904E7 1200000.0 0.68 1.234932E7 -306168.888888899 -0.179774674424098 0.3294 0.4679 3561841 PK04_181097 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E20 compound treatment 1.35366E7 -329000.0 -0.18 1.2932E7 -85000.0 -0.05 1.221964E7 -435848.888888899 -0.255919510249585 -0.2821 -0.8835 3561923 PK04_181098 CCCNC(=O)COc1ccc(C=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E21 compound treatment 1.362264E7 -243000.0 -0.14 1.240224E7 -615000.0 -0.35 1.174124E7 -914248.888888899 -0.536823963202339 -0.5885 -0.9011 3561841 PK04_181099 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E22 compound treatment 1.260552E7 -1260000.0 -0.71 1.234924E7 -668000.0 -0.38 1.152808E7 -1127408.8888889 -0.661986156328193 -1.0078 -0.9696 3561924 PK04_181100 CCCNC(=O)Cc1ccc(N)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E23 compound treatment 1.25782E7 -1290000.0 -0.72 1.19788E7 -1040000.0 -0.58 1.13348E7 -1320688.8888889 -0.775475313240209 -1.2026 -0.9933 3561841 PK04_181101 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 E24 compound treatment 1.174696E7 -2120000.0 -1.19 1.142192E7 -1600000.0 -0.9 1.074296E7 -1912528.8888889 -1.12298888229447 -1.8538 -0.9933 3561925 PK04_181102 CCOC(=O)/C=C/c1ccccc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F01 mock treatment 1.203568E7 -1830000.0 -1.03 1.218164E7 -835000.0 -0.47 1.173876E7 -916728.888888899 -0.538280156854769 -1.1757 -0.9391 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F02 mock treatment 1.411872E7 253000.0 0.14 1.255392E7 -463000.0 -0.26 1.224196E7 -413528.888888899 -0.242813767377709 -0.2086 -0.5438 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F03 compound treatment 1.314328E7 -722000.0 -0.41 1.248032E7 -537000.0 -0.3 1.286044E7 204951.111111101 0.120342139942982 -0.3392 -0.6523 3561927 PK04_181103 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F04 compound treatment 1.169268E7 -2170000.0 -1.22 1.092684E7 -2090000.0 -1.18 1.209048E7 -565008.888888899 -0.33175901514795 -1.5755 -0.912 1366116 PK04_181104 Brc1ccc2ncnc(NCC=C)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F05 compound treatment 1.38864E7 20800.0 0.01 1.2511E7 -506000.0 -0.28 1.20226E7 -632888.888888899 -0.371616444634641 -0.3722 -0.7948 3561928 PK04_181105 CN(CC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F06 compound treatment 1.339204E7 -474000.0 -0.27 1.284636E7 -171000.0 -0.1 1.060572E7 -2049768.8888889 -1.20357276006043 -0.9039 -0.7311 1945167 PK04_181106 C/C(=C/C(=O)c1ccc(Cl)cc1)/Nc2cccc(O)c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F07 compound treatment 1.37138E7 -152000.0 -0.09 1.3284E7 267000.0 0.15 1.319836E7 542871.111111101 0.318760268583857 0.2216 0.6111 3561929 PK04_181107 OC(CSc1nc2ccccc2s1)CC(O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F08 compound treatment 1.449892E7 633000.0 0.36 1.385928E7 842000.0 0.47 1.354996E7 894471.111111101 0.525210949307494 0.7824 0.9879 1448632 PK04_181108 Nn1cnc2-c3ccccc3CC4(CCCC4)c2c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F09 mock treatment 1.426704E7 401000.0 0.23 1.344416E7 427000.0 0.24 1.252188E7 -133608.888888899 -0.078451780608197 0.2237 0.6602 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F10 mock treatment 1.4454E7 588000.0 0.33 1.421192E7 1190000.0 0.67 1.347112E7 815631.111111101 0.478918083356836 0.8557 0.9621 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F11 compound treatment 1.433248E7 467000.0 0.26 1.384216E7 825000.0 0.46 1.348712E7 831631.111111101 0.488312881114453 0.7015 0.97 3561930 PK04_181109 OC(CSc1ccccn1)CC(O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F12 compound treatment 1.478472E7 919000.0 0.52 1.343104E7 414000.0 0.23 1.387172E7 1216231.1111111 0.714140332213175 0.8449 0.927 3561931 PK04_181110 [O-][N+](=O)c1ccccc1/C=C/c2ccncc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F13 compound treatment 7365640.0 -6500000.0 -3.65 6828360.0 -6190000.0 -3.48 7047800.0 -5607688.8888889 -3.29269393742176 -6.0202 -0.9991 3561933 PK04_181111 ONC(=O)CCCCCCC(=O)NOCc1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F14 compound treatment 1.574132E7 1880000.0 1.05 1.345012E7 433000.0 0.24 1.307936E7 423871.111111101 0.248886460261579 0.8927 0.8045 1679359 PK04_181112 OC(=O)CCCN1C(=O)CSC1=S 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F15 compound treatment 1.385868E7 -6910.0 0.0 1.340968E7 393000.0 0.22 1.286192E7 206431.111111101 0.121211158735562 0.1954 0.7748 1020755 PK04_181113 O=C(C[n+]1ccc2ccccc2c1)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F16 compound treatment 1.375884E7 -107000.0 -0.06 1.327048E7 253000.0 0.14 1.296872E7 313231.111111101 0.183921433767656 0.154 0.6404 3561934 PK04_181114 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F17 mock treatment 1.412972E7 264000.0 0.15 1.37152E7 698000.0 0.39 1.233072E7 -324768.888888899 -0.190696126817328 0.2025 0.4389 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F18 mock treatment 1.41826E7 317000.0 0.18 1.375456E7 738000.0 0.42 1.26214E7 -34088.8888888992 -0.0200161385558182 0.331 0.7319 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F19 compound treatment 1.381952E7 -46100.0 -0.03 1.31996E7 183000.0 0.1 1.297652E7 321031.111111101 0.188501397674495 0.1532 0.7086 3561936 PK04_181115 Brc1c2OCOc2ccc1C[n+]3ccc4ccccc4c3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F20 compound treatment 6394640.0 -7470000.0 -4.2 6312000.0 -6700000.0 -3.77 6136240.0 -6519248.8888889 -3.8279390526676 -6.8119 -0.9989 3561937 PK04_181116 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2/C=C/c3ccncc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F21 compound treatment 1.327736E7 -588000.0 -0.33 1.279752E7 -219000.0 -0.12 1.21002E7 -555288.888888899 -0.326051675510197 -0.4503 -0.9375 3561939 PK04_181117 CC(C)(C)[Si](C)(C)Oc1ccc2cc[n+](Cc3ccccc3Br)cc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F22 compound treatment 1.258604E7 -1280000.0 -0.72 1.206176E7 -955000.0 -0.54 1.130268E7 -1352808.8888889 -0.794335369738625 -1.184 -0.9878 1936946 PK04_181118 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F23 compound treatment 1.16684E7 -2200000.0 -1.23 1.0088E7 -2930000.0 -1.65 1.04084E7 -2247088.8888889 -1.31943410340624 -2.4262 -0.992 3561940 PK04_181119 COc1ccc(Br)c(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 F24 compound treatment 1.078732E7 -3080000.0 -1.73 1.0972E7 -2040000.0 -1.15 1.058676E7 -2068728.8888889 -1.21470559540321 -2.3642 -0.9825 3561941 PK04_181120 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G01 compound treatment 1.156632E7 -2300000.0 -1.29 1.194696E7 -1070000.0 -0.6 1.213168E7 -523808.888888899 -0.307567410922086 -1.271 -0.8718 3561841 PK04_181121 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G02 compound treatment 1.320232E7 -663000.0 -0.37 1.320808E7 191000.0 0.11 1.311604E7 460551.111111101 0.270424034120917 0.0031 0.0067 3561943 PK04_181122 O=C1CSC(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G03 mock treatment 1.380564E7 -60000.0 -0.03 1.311564E7 98700.0 0.06 1.268356E7 28071.1111111008 0.0164826507325245 0.0221 0.3304 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G04 mock treatment 1.391928E7 53700.0 0.03 1.274388E7 -273000.0 -0.15 1.287816E7 222671.111111101 0.130746878459543 0.0041 0.0203 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G05 compound treatment 1.241488E7 -1450000.0 -0.81 1.252744E7 -490000.0 -0.28 1.10712E7 -1584288.8888889 -0.930254606296952 -1.1666 -0.9208 PK04_181123 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G06 compound treatment 1.4005E7 139000.0 0.08 1.3098E7 81000.0 0.05 1.312136E7 465871.111111101 0.273547804375324 0.2295 0.7963 3561944 PK04_181124 CC(C)(C)c1ccc(cc1)N2C(SCC2=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G07 compound treatment 1.423712E7 372000.0 0.21 1.34378E7 421000.0 0.24 1.42028E7 1547311.1111111 0.908542184812669 0.7818 0.8128 PK04_181125 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G08 compound treatment 1.444916E7 584000.0 0.33 1.40218E7 1000000.0 0.57 1.331024E7 654751.111111101 0.384453391903995 0.7378 0.9728 3561945 PK04_181126 CCOC(=O)/C=C(\C)/c1ccccc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G09 compound treatment 1.326992E7 -596000.0 -0.33 1.263976E7 -377000.0 -0.21 1.218116E7 -474328.888888899 -0.278513998856655 -0.4766 -0.9839 3561841 PK04_181127 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G10 compound treatment 1.42708E7 405000.0 0.23 1.326608E7 249000.0 0.14 1.27298E7 74311.1111111008 0.0436336162520381 0.2376 0.877 3561947 PK04_181128 CCOC(=O)/C=C/c1c(OC)cccc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G11 compound treatment 1.377156E7 -94000.0 -0.05 1.204132E7 -976000.0 -0.55 1.199472E7 -660768.888888899 -0.387986879727289 -0.5716 -0.8474 3561899 PK04_181129 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G12 compound treatment 1.452532E7 660000.0 0.37 1.422316E7 1210000.0 0.68 1.39244E7 1268911.1111111 0.74507270383013 1.0361 0.9647 3561949 PK04_181130 CCCNC(=O)Cc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G13 compound treatment 1.327072E7 -595000.0 -0.33 1.242632E7 -591000.0 -0.33 1.292768E7 272191.111111101 0.159823777519368 -0.2926 -0.5879 3561950 PK04_181131 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)c6cccc(Cl)c6CO)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G14 compound treatment 1.414016E7 275000.0 0.15 1.38282E7 811000.0 0.46 1.249692E7 -158568.888888899 -0.0931076651100798 0.2989 0.6089 3561952 PK04_181132 COc1cc(/C=C/CO)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G15 compound treatment 1.35234E7 -342000.0 -0.19 1.234188E7 -675000.0 -0.38 1.191276E7 -742728.888888899 -0.436111731240683 -0.5822 -0.9551 3561841 PK04_181133 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G16 compound treatment 1.414444E7 279000.0 0.16 1.391108E7 894000.0 0.5 1.325224E7 596751.111111101 0.350397250032633 0.5833 0.9216 3561954 PK04_181134 COc1ccccc1/C=C/CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G17 compound treatment 1.295716E7 -908000.0 -0.51 1.228028E7 -737000.0 -0.41 1.166084E7 -994648.888888899 -0.584032821934365 -0.8712 -0.9906 3561956 PK04_181135 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G18 compound treatment 1.433136E7 466000.0 0.26 1.341024E7 393000.0 0.22 1.25036E7 -151888.888888899 -0.0891853370462746 0.2274 0.642 3561958 PK04_181136 O=C1CS(=O)(=O)C(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G19 mock treatment 1.363036E7 -235000.0 -0.13 1.228276E7 -734000.0 -0.41 1.311168E7 456191.111111101 0.267863951731966 -0.1603 -0.3143 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G20 mock treatment 1.416588E7 300000.0 0.17 1.363704E7 620000.0 0.35 1.257436E7 -81128.8888888992 -0.0476368439632127 0.2714 0.6949 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G21 compound treatment 1.33122E7 -553000.0 -0.31 1.415E7 1130000.0 0.64 1.257748E7 -78008.8888888992 -0.0458048584004773 0.1623 0.2283 3561959 PK04_181137 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G22 compound treatment 1.305E7 -816000.0 -0.46 1.282508E7 -192000.0 -0.11 1.187004E7 -785448.888888899 -0.46119584125352 -0.5931 -0.9001 3561961 PK04_181138 CC(C)(C)c1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G23 compound treatment 1.162476E7 -2240000.0 -1.26 1.145204E7 -1560000.0 -0.88 1.1105E7 -1550488.8888889 -0.910408096033985 -1.7609 -0.9861 3561959 PK04_181139 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 G24 compound treatment 1.194656E7 -1920000.0 -1.08 1.091736E7 -2100000.0 -1.18 1.080204E7 -1853448.8888889 -1.08829859157447 -1.933 -0.9991 2093329 PK04_181140 COC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H01 compound treatment 1.362556E7 -240000.0 -0.13 1.233108E7 -686000.0 -0.39 1.15942E7 -1061288.8888889 -0.62316215459484 -0.6605 -0.8862 3561962 PK04_181141 Brc1ccccc1C(=O)[n+]2ccc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H02 compound treatment 1.334276E7 -523000.0 -0.29 1.256688E7 -450000.0 -0.25 1.247208E7 -183408.888888899 -0.10769308862878 -0.378 -0.9391 3561963 PK04_181142 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)O)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H03 mock treatment 1.375476E7 -111000.0 -0.06 1.242708E7 -590000.0 -0.33 1.26254E7 -30088.8888888992 -0.0176674391164139 -0.2379 -0.7031 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H04 mock treatment 1.381632E7 -49300.0 -0.03 1.261692E7 -400000.0 -0.23 1.250176E7 -153728.888888899 -0.0902657387884006 -0.1981 -0.8113 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H05 compound treatment 1.21102E7 -1760000.0 -0.99 1.33234E7 306000.0 0.17 1.134608E7 -1309408.8888889 -0.768851980821089 -0.9136 -0.7238 3561965 PK04_181143 COc1cc2CC[N+](=Cc2cc1O[Si](C)(C)C(C)(C)C)Cc3ccccc3Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H06 compound treatment 1.410168E7 236000.0 0.13 1.4325E7 1310000.0 0.74 1.279316E7 137671.111111101 0.0808370153722021 0.5483 0.7287 3561966 PK04_181144 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H07 compound treatment 1.42202E7 355000.0 0.2 1.517276E7 2160000.0 1.21 1.257096E7 -84528.8888888992 -0.0496332384867063 0.787 0.6394 3561968 PK04_181145 COc1cc2CC[N+](=Cc2cc1OC)C(=O)c3ccccc3Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H08 compound treatment 1.40198E7 154000.0 0.09 1.281596E7 -201000.0 -0.11 1.38914E7 1235911.1111111 0.725695933455045 0.4037 0.5458 3561969 PK04_181146 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3C4CC5CC(C4)CC3C5)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H09 compound treatment 1.440472E7 539000.0 0.3 1.318456E7 168000.0 0.09 1.248768E7 -167808.888888899 -0.0985331608151037 0.1724 0.5191 3561971 PK04_181147 Oc1ccc2CCN(Cc3ccccc3Br)C(C=C)c2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H10 compound treatment 1.07374E7 -3130000.0 -1.76 9705680.0 -3310000.0 -1.86 9197480.0 -3458008.8888889 -2.0304558846971 -3.2629 -0.9982 3561972 PK04_181148 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(O)(C4)C3)C5)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H11 compound treatment 1.37432E7 -122000.0 -0.07 1.284328E7 -174000.0 -0.1 1.255464E7 -100848.888888899 -0.0592159321994758 -0.1303 -0.9771 3561974 PK04_181149 Brc1c[n+](Cc2ccccc2)cc3ccccc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H12 compound treatment 1.407584E7 210000.0 0.12 1.452536E7 1510000.0 0.85 1.404044E7 1384951.1111111 0.813208474567248 1.0279 0.8699 3561975 PK04_181150 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NCC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H13 compound treatment 1.438588E7 520000.0 0.29 1.33694E7 352000.0 0.2 1.209076E7 -564728.888888899 -0.331594606187192 0.0918 0.1895 3561977 PK04_181151 COc1ccc(Br)c(C[n+]2cc(Br)c3ccccc3c2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H14 compound treatment 1.458924E7 724000.0 0.41 1.343988E7 423000.0 0.24 1.256816E7 -87328.8888888992 -0.0512773280942893 0.3425 0.7229 3561978 PK04_181152 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H15 compound treatment 1.442556E7 560000.0 0.31 1.32642E7 247000.0 0.14 1.28212E7 165711.111111101 0.0973013984424262 0.3181 0.89 1003512 PK04_181153 C[n+]1ccc2ccccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H16 compound treatment 1.26442E7 -1220000.0 -0.69 1.093392E7 -2080000.0 -1.17 1.048032E7 -2175168.8888889 -1.27720448748575 -1.8105 -0.971 3561980 PK04_181154 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H17 compound treatment 1.418384E7 318000.0 0.18 1.343648E7 419000.0 0.24 1.265432E7 -1168.88888889924 -6.86342169520886E-4 0.2391 0.8075 1032420 PK04_181155 C(c1ccccc1)[n+]2ccc3ccccc3c2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H18 compound treatment 1.19676E7 -1900000.0 -1.07 1.247312E7 -544000.0 -0.31 1.130332E7 -1352168.8888889 -0.793959577828321 -1.2506 -0.9169 3561982 PK04_181156 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H19 mock treatment 1.318308E7 -683000.0 -0.38 1.3194E7 177000.0 0.1 1.238812E7 -267368.888888899 -0.156992289861877 -0.2544 -0.5972 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H20 mock treatment 1.429356E7 428000.0 0.24 1.326296E7 246000.0 0.14 1.250156E7 -153928.888888899 -0.0903831737603708 0.1665 0.5708 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H21 compound treatment 1.308448E7 -781000.0 -0.44 1.229768E7 -719000.0 -0.4 1.274576E7 90271.1111111008 0.0530049270152612 -0.4565 -0.7616 3561984 PK04_181157 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H22 compound treatment 436680.0 -1.34E7 -7.54 497800.0 -1.25E7 -7.05 421320.0 -1.22341688888889E7 -7.1835964027277 -12.571 -0.9996 3561985 PK04_181158 O=C1C=C[C@@H]2[C@@H]3C=C[C@H]([C@@H]2[C@]41CO4)[C@@]5(CO5)C3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H23 compound treatment 679560.0 -1.32E7 -7.41 307560.0 -1.27E7 -7.15 289560.0 -1.23659288888889E7 -7.26096256226167 -12.5987 -0.9999 3561987 PK04_181159 COc1ccc(Br)c(C[n+]2ccc3c(cccc3c2)[N+](=O)[O-])c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 H24 compound treatment 1.1346E7 -2520000.0 -1.42 1.017512E7 -2840000.0 -1.6 1.104092E7 -1614568.8888889 -0.948034261053242 -2.288 -0.9791 3561988 PK04_181160 CC1(C)C[C@H]2C[C@H]3C(=C[C@]2(CO1)C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I01 compound treatment 1.006192E7 -3800000.0 -2.14 1.034796E7 -2670000.0 -1.5 1.058012E7 -2075368.8888889 -1.21860443647262 -2.8045 -0.9731 3561956 PK04_181161 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I02 compound treatment 1.287652E7 -989000.0 -0.56 1.204744E7 -970000.0 -0.55 1.27212E7 65711.1111111008 0.0385839124573189 -0.6136 -0.7869 3561990 PK04_181162 CCCNC(=O)Cc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I03 compound treatment 1.062112E7 -3240000.0 -1.82 1.016164E7 -2860000.0 -1.61 1.01274E7 -2528088.8888889 -1.48443023902439 -2.8372 -0.9964 3561991 PK04_181163 OCc1c(Cl)cccc1N2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OCC=C)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I04 compound treatment 1.452308E7 657000.0 0.37 1.2662E7 -355000.0 -0.2 1.21754E7 -480088.888888899 -0.281896126049397 -0.0649 -0.1283 3561993 PK04_181164 COc1ccccc1/C(=C/CO)/C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I05 mock treatment 1.364028E7 -225000.0 -0.13 1.280644E7 -211000.0 -0.12 1.22862E7 -369288.888888899 -0.216837151577898 -0.2667 -0.9606 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I06 mock treatment 1.464836E7 783000.0 0.44 1.404096E7 1020000.0 0.58 1.297072E7 315231.111111101 0.185095783487359 0.6935 0.9269 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I07 compound treatment 1.350352E7 -362000.0 -0.2 1.199296E7 -1020000.0 -0.58 1.193636E7 -719128.888888899 -0.422254404548197 -0.694 -0.9342 3561995 PK04_181165 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I08 compound treatment 1.551356E7 1650000.0 0.93 1.257192E7 -445000.0 -0.25 1.292272E7 267231.111111101 0.156911390214507 0.4804 0.4944 3561996 PK04_181166 COc1ccccc1/C(=C/C=O)/C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I09 compound treatment 1.47654E7 900000.0 0.51 1.344536E7 428000.0 0.24 1.258984E7 -65648.8888888992 -0.0385473771327181 0.4088 0.7282 3561998 PK04_181167 OCc1c(Cl)cccc1N2[C@@H](C(=O)NCc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)O)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I10 compound treatment 1.288644E7 -979000.0 -0.55 1.297132E7 -45700.0 -0.03 1.089736E7 -1758128.8888889 -1.03232908393346 -0.9284 -0.7935 2069262 PK04_181168 COc1cc(/C=C/C=O)cc(OC)c1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I11 compound treatment 1.254484E7 -1320000.0 -0.74 1.290532E7 -112000.0 -0.06 1.112996E7 -1525528.8888889 -0.895752211532103 -0.9818 -0.8429 3562000 PK04_181169 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4ccccc4Cl)C(=O)N(CC=C)Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I12 compound treatment 1.399184E7 126000.0 0.07 1.297968E7 -37300.0 -0.02 1.31406E7 485111.111111101 0.284845048678859 0.1933 0.6567 3562002 PK04_181170 CCOC(=O)/C=C/c1cccc(c1)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I13 compound treatment 1.463816E7 773000.0 0.43 1.283268E7 -184000.0 -0.1 1.148516E7 -1170328.8888889 -0.687187701313001 -0.2061 -0.2516 3562003 PK04_181171 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N(Cc4ccccc4)[C@@H]5C(=O)N(Cc6ccccc6)CC=C[C@]35O[C@@H]2/C=C/CCC(=O)N1C)c7ccccc7 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I14 compound treatment 1.265928E7 -1210000.0 -0.68 1.45652E7 1550000.0 0.87 1.099808E7 -1657408.8888889 -0.973188832049262 -0.4499 -0.3057 3562005 PK04_181172 COc1cccc(OC)c1/C=C/CO 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I15 compound treatment 1.324268E7 -623000.0 -0.35 1.302968E7 12700.0 0.01 1.239992E7 -255568.888888899 -0.150063626515634 -0.2845 -0.7472 3562007 PK04_181173 CCCCNC(=O)[C@@H]1N(C2CCCCC2)C(=O)[C@H]3[C@@H]([C@H]4O[C@@]13C=C4)C(=O)OCC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I16 compound treatment 1.36882E7 -177000.0 -0.1 1.306856E7 51600.0 0.03 1.239356E7 -261928.888888899 -0.153798058624287 -0.1296 -0.6983 3562009 PK04_181174 Clc1cccc(c1)N2C(SCC2=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I17 compound treatment 1.37308E7 -135000.0 -0.08 1.155724E7 -1460000.0 -0.82 1.193344E7 -722048.888888899 -0.423968955138962 -0.7629 -0.8223 3561995 PK04_181175 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I18 compound treatment 1.381712E7 -48500.0 -0.03 1.243972E7 -577000.0 -0.32 1.2725E7 69511.1111111008 0.040815176924753 -0.1798 -0.547 3065130 PK04_181176 Clc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I19 compound treatment 1.206372E7 -1800000.0 -1.01 1.140452E7 -1610000.0 -0.91 1.197176E7 -683728.888888899 -0.401468414509469 -1.3402 -0.9454 3562010 PK04_181177 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I20 compound treatment 1.347528E7 -390000.0 -0.22 1.226704E7 -750000.0 -0.42 1.196104E7 -694448.888888899 -0.407762929007073 -0.6057 -0.9668 3562012 PK04_181178 OC/C=C/c1cccc(c1)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I21 mock treatment 1.288852E7 -977000.0 -0.55 1.250908E7 -508000.0 -0.29 1.157672E7 -1078768.8888889 -0.633425971145037 -0.8476 -0.9572 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I22 mock treatment 1.28528E7 -1010000.0 -0.57 1.188336E7 -1130000.0 -0.64 1.17004E7 -955088.888888899 -0.560804184478656 -1.0206 -0.9983 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I23 compound treatment 1.195428E7 -1910000.0 -1.07 1.029192E7 -2730000.0 -1.53 1.114776E7 -1507728.8888889 -0.885300499026753 -2.0166 -0.9737 3562014 PK04_181179 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N([C@@H]4C(=O)N(Cc5ccccc5)CC=C[C@]34O[C@@H]2/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 I24 compound treatment 1.131516E7 -2550000.0 -1.43 1.089108E7 -2130000.0 -1.2 1.189896E7 -756528.888888899 -0.444214744306627 -1.7744 -0.9248 3215604 PK04_181180 O=C/1N(C(c2ccccc2)S(=O)(=O)\C1=C/c3ccc4ccccc4c3)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J01 compound treatment 1.271724E7 -1150000.0 -0.65 1.258604E7 -431000.0 -0.24 1.15026E7 -1152888.8888889 -0.676947371757199 -0.9033 -0.9351 3562016 PK04_181181 COc1ccc(Br)c(C[n+]2ccccc2C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J02 compound treatment 1.099408E7 -2870000.0 -1.61 1.026368E7 -2750000.0 -1.55 1.025756E7 -2397928.8888889 -1.40800355926618 -2.6389 -0.9984 3562017 PK04_181182 OCCCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J03 compound treatment 1.288888E7 -977000.0 -0.55 1.230132E7 -716000.0 -0.4 1.165148E7 -1004008.8888889 -0.589528778622571 -0.8897 -0.9881 3562019 PK04_181183 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J04 compound treatment 1.183484E7 -2030000.0 -1.14 1.105768E7 -1960000.0 -1.1 1.071672E7 -1938768.8888889 -1.13839635061696 -1.9526 -0.9999 3562020 PK04_181184 OCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J05 mock treatment 1.521984E7 1350000.0 0.76 1.26716E7 -345000.0 -0.19 1.284184E7 186351.111111101 0.109420687549752 0.3901 0.4921 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J06 mock treatment 1.43676E7 502000.0 0.28 1.341724E7 400000.0 0.23 1.281268E7 157191.111111101 0.092298668636495 0.3462 0.9292 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J07 compound treatment 1.351816E7 -347000.0 -0.2 1.249628E7 -521000.0 -0.29 1.261344E7 -42048.8888888992 -0.0246900504402328 -0.2961 -0.839 3562022 PK04_181185 Cc1[n+](Cc2ccccc2)ccc3ccccc13 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J08 compound treatment 1.289496E7 -971000.0 -0.55 1.11086E7 -1910000.0 -1.07 1.093632E7 -1719168.8888889 -1.00945275139366 -1.5178 -0.9657 3562023 PK04_181186 BrC1=C[C@@]2(Br)[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J09 compound treatment 1.261212E7 -1250000.0 -0.7 1.185256E7 -1160000.0 -0.66 1.182196E7 -833528.888888899 -0.48942720851516 -1.0675 -0.9891 3562025 PK04_181187 COc1ccc(Br)c(C[n+]2cccc3cc(OC)ccc23)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J10 compound treatment 1.276484E7 -1100000.0 -0.62 1.179524E7 -1220000.0 -0.69 1.11846E7 -1470888.8888889 -0.86366897718984 -1.2527 -0.99 3562026 PK04_181188 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@]2(Br)C(=O)[C@@]43CO4)Br 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J11 compound treatment 1.410192E7 236000.0 0.13 1.30004E7 -16600.0 -0.01 1.290076E7 245271.111111101 0.144017030292178 0.1544 0.7874 3562028 PK04_181189 COc1ccc(Br)c(C[N+]2=C(C)CCC2)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J12 compound treatment 1.355632E7 -309000.0 -0.17 1.164576E7 -1370000.0 -0.77 1.211332E7 -542168.888888899 -0.318347941348951 -0.7297 -0.8557 3562029 PK04_181190 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J13 compound treatment 1.480224E7 937000.0 0.53 1.399444E7 977000.0 0.55 1.332304E7 667551.111111101 0.391969230110089 0.8477 0.99 3562031 PK04_181191 COc1ccc(Br)c(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J14 compound treatment 1.392116E7 55600.0 0.03 1.2495E7 -522000.0 -0.29 1.190452E7 -750968.888888899 -0.440950052085855 -0.4062 -0.7653 3562032 PK04_181192 COc1ccc(CCNC(=O)[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J15 compound treatment 1.313024E7 -735000.0 -0.41 1.242452E7 -592000.0 -0.33 1.220612E7 -449368.888888899 -0.263858114354772 -0.5834 -0.984 3562033 PK04_181193 COC(CN(Cc1cccc(OC)c1)S(=O)(=O)c2ccc(C)cc2)OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J16 compound treatment 1.25048E7 -1360000.0 -0.76 1.155604E7 -1460000.0 -0.82 1.089268E7 -1762808.8888889 -1.03507706227757 -1.5137 -0.9912 3562034 PK04_181194 COc1ccc(CCN2C(=O)C3(CC(=O)N(Cc4ccccc4)C3c5ccccc5)c6cc(ccc26)[N+](=O)[O-])cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J17 compound treatment 1.37542E7 -111000.0 -0.06 1.264224E7 -375000.0 -0.21 1.140488E7 -1250608.8888889 -0.734326099061846 -0.5819 -0.7591 3562035 PK04_181195 COc1ccc(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J18 compound treatment 1.220852E7 -1660000.0 -0.93 1.210792E7 -909000.0 -0.51 1.115716E7 -1498328.8888889 -0.879781055344153 -1.3408 -0.9721 3562036 PK04_181196 C[C@@]1(CCc2ccccc2)C[C@@H](C[Si](C)(C)C(c3ccccc3)c4ccccc4)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J19 compound treatment 1.296144E7 -904000.0 -0.51 1.224952E7 -767000.0 -0.43 1.206204E7 -593448.888888899 -0.348458268162114 -0.7438 -0.9887 3562038 PK04_181197 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J20 compound treatment 1.360816E7 -257000.0 -0.14 1.279756E7 -219000.0 -0.12 1.225092E7 -404568.888888899 -0.237552680633444 -0.2919 -0.9594 3562039 PK04_181198 CCCCCCC1C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J21 mock treatment 1.319388E7 -672000.0 -0.38 1.25814E7 -436000.0 -0.25 1.167372E7 -981768.888888899 -0.576470009739483 -0.6922 -0.9466 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J22 mock treatment 1.364456E7 -221000.0 -0.12 1.214648E7 -871000.0 -0.49 1.1649E7 -1006488.8888889 -0.590984972275002 -0.6958 -0.8947 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J23 compound treatment 1.186416E7 -2000000.0 -1.12 1.02444E7 -2770000.0 -1.56 1.03298E7 -2325688.8888889 -1.36558604739054 -2.3385 -0.9914 3562041 PK04_181199 COc1cc2CCN(CC=C)C(C#Cc3ccccc3)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 J24 compound treatment 1.245576E7 -1410000.0 -0.79 1.206452E7 -952000.0 -0.54 1.037516E7 -2280328.8888889 -1.33895179574769 -1.5398 -0.9358 3562042 PK04_181200 Cc1ccc(cc1)C2C[C@]3(CC[C@@H](CC3)C(C)(C)C)OO2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K01 compound treatment 1.143708E7 -2430000.0 -1.36 1.084792E7 -2170000.0 -1.22 1.055744E7 -2098048.8888889 -1.23192156229404 -2.2037 -0.9987 3562010 PK04_181201 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K02 compound treatment 1.2323E7 -1540000.0 -0.87 1.176508E7 -1250000.0 -0.7 1.210064E7 -554848.888888899 -0.325793318571863 -1.0952 -0.9414 3215602 PK04_181202 Cc1c(NC(=O)/C(=C/c2ccc3ccccc3c2)/C#N)c(=O)n(c4ccccc4)n1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K03 compound treatment 1.139564E7 -2470000.0 -1.39 1.086084E7 -2160000.0 -1.21 1.133904E7 -1316448.8888889 -0.77298569183444 -1.948 -0.9746 3562044 PK04_181203 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K04 compound treatment 1.178384E7 -2080000.0 -1.17 1.103748E7 -1980000.0 -1.11 1.07484E7 -1907088.8888889 -1.11979465105688 -1.9649 -0.9998 3562046 PK04_181204 COc1cccc(OC)c1/C=C/C=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K05 compound treatment 1.2014E7 -1850000.0 -1.04 1.173424E7 -1280000.0 -0.72 1.097372E7 -1681768.8888889 -0.987492411635234 -1.5875 -0.9887 2065615 PK04_181205 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K06 compound treatment 1.240584E7 -1460000.0 -0.82 1.185988E7 -1160000.0 -0.65 1.17314E7 -924088.888888899 -0.542601763823273 -1.1627 -0.9859 3562048 PK04_181206 Clc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K07 mock treatment 1.329516E7 -570000.0 -0.32 1.209232E7 -925000.0 -0.52 1.228336E7 -372128.888888899 -0.218504728179875 -0.6116 -0.9423 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K08 mock treatment 1.330884E7 -557000.0 -0.31 1.295768E7 -59300.0 -0.03 1.223044E7 -425048.888888899 -0.249578021763194 -0.3439 -0.8566 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K09 compound treatment 1.169376E7 -2170000.0 -1.22 1.130108E7 -1720000.0 -0.97 1.0684E7 -1971488.8888889 -1.15760871203129 -1.9303 -0.9953 3562049 PK04_181207 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K10 compound treatment 1.449228E7 627000.0 0.35 1.305556E7 38600.0 0.02 1.281868E7 163191.111111101 0.0958217177956015 0.2711 0.7418 3562051 PK04_181208 Clc1cccc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K11 compound treatment 1.251056E7 -1360000.0 -0.76 1.17928E7 -1220000.0 -0.69 1.120664E7 -1448848.8888889 -0.850727643278722 -1.3284 -0.9963 3562052 PK04_181209 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K12 compound treatment 1.390384E7 38200.0 0.02 1.327132E7 254000.0 0.14 1.23378E7 -317688.888888899 -0.186538928809583 -0.0126 -0.0535 3562054 PK04_181210 O=C1CSCN1c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K13 compound treatment 1.226232E7 -1600000.0 -0.9 1.205564E7 -961000.0 -0.54 1.213068E7 -524808.888888899 -0.308154585781937 -1.0103 -0.9227 3562052 PK04_181211 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K14 compound treatment 1.435784E7 492000.0 0.28 1.34324E7 415000.0 0.23 1.286924E7 213751.111111101 0.125509278709672 0.3671 0.9579 1951450 PK04_181212 Cc1c(N2C(SCC2=O)c3ccccc3)c(=O)n(c4ccccc4)n1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K15 mock treatment 1.382328E7 -42300.0 -0.02 1.28446E7 -172000.0 -0.1 1.197052E7 -684968.888888899 -0.402196511335685 -0.302 -0.7286 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K16 mock treatment 1.375856E7 -107000.0 -0.06 1.23228E7 -694000.0 -0.39 1.204148E7 -614008.888888899 -0.360530583280652 -0.4685 -0.8755 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K17 compound treatment 1.295144E7 -914000.0 -0.51 1.157964E7 -1440000.0 -0.81 1.094452E7 -1710968.8888889 -1.00463791754289 -1.3436 -0.9678 3562052 PK04_181213 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K18 compound treatment 1.401156E7 146000.0 0.08 1.258088E7 -436000.0 -0.25 1.21674E7 -488088.888888899 -0.286593524928205 -0.2599 -0.6729 3562055 PK04_181214 CN1C(SCC1=O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K19 compound treatment 1.285768E7 -1010000.0 -0.57 1.25456E7 -471000.0 -0.27 1.123436E7 -1421128.8888889 -0.834451156163651 -0.9618 -0.9224 3562056 PK04_181215 COCOc1ccc2cc(Br)ccc2c1c3c(OCOC)ccc4cc(Br)ccc34 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K20 compound treatment 1.270124E7 -1160000.0 -0.65 1.184764E7 -1170000.0 -0.66 1.166236E7 -993128.888888899 -0.583140316147391 -1.0943 -0.9985 3562057 PK04_181216 O=C1CS(=O)(=O)CN1c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K21 compound treatment 1.199848E7 -1870000.0 -1.05 1.16124E7 -1400000.0 -0.79 1.131412E7 -1341368.8888889 -0.787618089341929 -1.5167 -0.9904 3220192 PK04_181217 CC(CO)N1C2C(=O)N(Cc3ccccc3)CC=CC42OC5C=CCOC(=O)C5C4C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K22 compound treatment 1.201208E7 -1850000.0 -1.04 1.209996E7 -917000.0 -0.52 1.135476E7 -1300728.8888889 -0.763755303037581 -1.3401 -0.9637 3562058 PK04_181218 CN1C(c2ccccc2)S(=O)(=O)CC1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K23 mock treatment 1.26742E7 -1190000.0 -0.67 1.12694E7 -1750000.0 -0.98 1.118316E7 -1472328.8888889 -0.864514508988026 -1.4534 -0.9883 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 K24 mock treatment 1.115444E7 -2710000.0 -1.52 1.09728E7 -2040000.0 -1.15 1.093244E7 -1723048.8888889 -1.01173098984989 -2.1277 -0.9849 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L01 compound treatment 1.049552E7 -3370000.0 -1.89 9990720.0 -3030000.0 -1.7 1.08388E7 -1816688.8888889 -1.06671404372634 -2.6923 -0.9751 3562059 PK04_181219 COc1cc2CC[N+](=Cc2cc1OC)Cc3ccc(Br)cc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L02 compound treatment 1.13868E7 -2480000.0 -1.39 1.081448E7 -2200000.0 -1.24 1.041416E7 -2241328.8888889 -1.3160519762135 -2.2795 -0.9989 3562060 PK04_181220 CCOC(=O)CCC1(C)C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L03 compound treatment 1.180568E7 -2060000.0 -1.16 1.186632E7 -1150000.0 -0.65 1.108488E7 -1570608.8888889 -0.922222054214189 -1.5744 -0.9748 3562062 PK04_181221 Cc1cc2ccccc2c[n+]1CCCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L04 compound treatment 267360.0 -1.36E7 -7.64 386800.0 -1.26E7 -7.11 313520.0 -1.23419688888889E7 -7.24689385261964 -12.6985 -0.9995 3562063 PK04_181222 CC1(CCc2ccccc2)CC(CO)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L05 compound treatment 1.257696E7 -1290000.0 -0.72 1.174812E7 -1270000.0 -0.71 1.149016E7 -1165328.8888889 -0.684251827013746 -1.2253 -0.9997 3562064 PK04_181223 COc1ccc(Br)c(C[n+]2cc3ccccc3cc2C)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L06 compound treatment 8237640.0 -5630000.0 -3.16 1.040604E7 -2610000.0 -1.47 7251880.0 -5403608.8888889 -3.17286329202335 -4.5055 -0.9558 3562065 PK04_181224 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CC(C)(C)CO)OO2)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L07 mock treatment 1.327084E7 -595000.0 -0.33 1.245728E7 -560000.0 -0.32 1.293644E7 280951.111111101 0.164967429291664 -0.2795 -0.5729 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L08 mock treatment 1.43608E7 495000.0 0.28 1.299184E7 -25100.0 -0.01 1.312964E7 474151.111111101 0.278409612214891 0.3132 0.7952 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L09 compound treatment 1.45852E7 720000.0 0.4 1.350128E7 484000.0 0.27 1.274368E7 88191.1111111008 0.051783603306771 0.4207 0.858 3562067 PK04_181225 CC1=[N+](C)C2C3CC=CC3C1c4ccccc24 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L10 compound treatment 4888800.0 -8980000.0 -5.04 1766040.0 -1.13E7 -6.33 4063400.0 -8592088.8888889 -5.0450585891613 -9.4803 -0.9939 3562068 PK04_181226 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L11 compound treatment 1.356876E7 -297000.0 -0.17 1.2968E7 -49000.0 -0.03 1.274904E7 93551.1111111008 0.0549308605555728 -0.0805 -0.4528 1006359 PK04_181227 Cc1cccc[n+]1C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L12 compound treatment 9953680.0 -3910000.0 -2.2 1.006492E7 -2950000.0 -1.66 1.08466E7 -1808888.8888889 -1.0621340798195 -2.8412 -0.9623 3562070 PK04_181228 CC1(CCOCc2ccccc2)CC(C)(CCc3ccccc3)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L13 compound treatment 1.403984E7 174000.0 0.1 1.339436E7 377000.0 0.21 1.343544E7 779951.111111101 0.457967684357349 0.4436 0.8626 3562071 PK04_181229 C[n+]1cc2ccccc2cc1C#N 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L14 compound treatment 1.205648E7 -1810000.0 -1.02 1.063948E7 -2380000.0 -1.34 9709840.0 -2945648.8888889 -1.72961097350381 -2.3579 -0.9778 3562072 PK04_181230 COc1ccc(CN/2C(C3CC3)c4ccccc4C\C2=N\P(=O)(Oc5ccccc5)Oc6ccccc6)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L15 mock treatment 1.401532E7 150000.0 0.08 1.38834E7 866000.0 0.49 1.263704E7 -18448.8888888992 -0.0108327237477474 0.3239 0.6543 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L16 mock treatment 1.37482E7 -117000.0 -0.07 1.341068E7 394000.0 0.22 1.239412E7 -261368.888888899 -0.15346924070277 0.0013 0.0046 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L17 compound treatment 1.326716E7 -598000.0 -0.34 1.222236E7 -795000.0 -0.45 1.23056E7 -349888.888888899 -0.205445959296787 -0.5709 -0.9579 3562074 PK04_181231 CCCCOC1CC2[N+](=C(C)C1c3ccccc23)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L18 compound treatment 1.279656E7 -1070000.0 -0.6 1.327696E7 260000.0 0.15 1.208356E7 -571928.888888899 -0.335822265178119 -0.4561 -0.6484 3562075 PK04_181232 CCCCCCC1C[C@]2(CCC[C@@H](C)C2)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L19 compound treatment 1.296668E7 -899000.0 -0.5 1.274216E7 -275000.0 -0.15 1.197236E7 -683128.888888899 -0.401116109593559 -0.6124 -0.9235 3188663 PK04_181233 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L20 compound treatment 966440.0 -1.29E7 -7.25 1130640.0 -1.19E7 -6.69 895960.0 -1.17595288888889E7 -6.90489972724798 -12.0326 -0.9995 3562077 PK04_181234 CC1(CCO)CC(C)(CCc2ccccc2)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L21 compound treatment 1.161948E7 -2250000.0 -1.26 1.1315E7 -1700000.0 -0.96 1.056592E7 -2089568.8888889 -1.2269423194825 -1.9899 -0.9931 3070955 PK04_181235 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L22 compound treatment 1.0253E7 -3610000.0 -2.03 9935960.0 -3080000.0 -1.73 1.01256E7 -2529888.8888889 -1.48548715377213 -3.0305 -0.992 3562078 PK04_181236 COC(=O)CC1(C)CC(C)(CCc2ccccc2)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L23 mock treatment 1.191196E7 -1950000.0 -1.1 1.16034E7 -1410000.0 -0.8 1.17948E7 -860688.888888899 -0.505374877708715 -1.3847 -0.9572 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 L24 mock treatment 1.162316E7 -2240000.0 -1.26 1.068756E7 -2330000.0 -1.31 1.152788E7 -1127608.8888889 -0.662103591300164 -1.8665 -0.9646 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M01 compound treatment 1.066268E7 -3200000.0 -1.8 1.056256E7 -2450000.0 -1.38 9849600.0 -2805888.8888889 -1.64754741509102 -2.7876 -0.9943 3562079 PK04_181237 CC(C)(C)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C\COC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M02 compound treatment 9518440.0 -4350000.0 -2.44 9567280.0 -3450000.0 -1.94 9950040.0 -2705448.8888889 -1.58857157216758 -3.448 -0.9849 3562081 PK04_181238 Clc1ccccc1/C=C/C=C\2/C(=O)N(CS2(=O)=O)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M03 compound treatment 1.143396E7 -2430000.0 -1.37 1.078504E7 -2230000.0 -1.26 1.0887E7 -1768488.8888889 -1.03841221548152 -2.1134 -0.9938 3562049 PK04_181239 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M04 compound treatment 1155160.0 -1.27E7 -7.14 1006840.0 -1.2E7 -6.76 695440.0 -1.19600488888889E7 -7.02264003014532 -12.0796 -0.9997 3562083 PK04_181240 CN1C(c2ccccc2)S(=O)(=O)/C(=C\C=C\c3ccccc3Cl)/C1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M05 compound treatment 1.167536E7 -2190000.0 -1.23 1.118108E7 -1840000.0 -1.03 1.109924E7 -1556248.8888889 -0.913790223226728 -1.8345 -0.9925 3562085 PK04_181241 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M06 compound treatment 1.332068E7 -545000.0 -0.31 1.322584E7 209000.0 0.12 1.315492E7 499431.111111101 0.293253392671926 0.0605 0.1375 1053847 PK04_181242 O=C1CSC(N1c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M07 compound treatment 1.277252E7 -1090000.0 -0.61 1.20662E7 -951000.0 -0.54 1.203164E7 -623848.888888899 -0.366308383901587 -0.875 -0.9797 3562085 PK04_181243 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M08 compound treatment 1.112744E7 -2740000.0 -1.54 1.083704E7 -2180000.0 -1.23 1.105648E7 -1599008.8888889 -0.938897820233959 -2.1385 -0.9809 3562087 PK04_181244 COc1ccccc1/C=C/C=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M09 mock treatment 1.358864E7 -277000.0 -0.16 1.274968E7 -267000.0 -0.15 1.229256E7 -362928.888888899 -0.213102719469245 -0.2997 -0.9868 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M10 mock treatment 1.383464E7 -31000.0 -0.02 1.353612E7 519000.0 0.29 1.298552E7 330031.111111101 0.193785971413155 0.2706 0.7707 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M11 compound treatment 1.380616E7 -59400.0 -0.03 1.300876E7 -8220.0 0.0 1.265688E7 1391.11111110076 8.16825471697861E-4 -0.0215 -0.637 3562085 PK04_181245 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M12 compound treatment 1.355804E7 -308000.0 -0.17 1.314328E7 126000.0 0.07 1.285444E7 198951.111111101 0.116819090783876 0.0088 0.0397 3562088 PK04_181246 O=C1CS(=O)(=O)C(N1c2ccccc2)c3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M13 mock treatment 1.432076E7 455000.0 0.26 1.386248E7 845000.0 0.48 1.390168E7 1246191.1111111 0.731732091014314 0.8449 0.9289 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M14 mock treatment 1.386412E7 -1470.0 0.0 1.370512E7 688000.0 0.39 1.295172E7 296231.111111101 0.173939461150188 0.3236 0.7621 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M15 compound treatment 1.318268E7 -683000.0 -0.38 1.234132E7 -676000.0 -0.38 1.19764E7 -679088.888888899 -0.39874392315976 -0.6713 -0.9998 3562089 PK04_181247 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M16 compound treatment 1.250312E7 -1360000.0 -0.77 1.096276E7 -2050000.0 -1.16 1.146792E7 -1187568.8888889 -0.697310595896834 -1.512 -0.9742 2118235 PK04_181248 [O-][N+](=O)c1cccc(/C=C/C=O)c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M17 compound treatment 1.31924E7 -673000.0 -0.38 1.270072E7 -316000.0 -0.18 1.252188E7 -133608.888888899 -0.078451780608197 -0.3664 -0.8616 3562089 PK04_181249 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M18 compound treatment 1.2494E7 -1370000.0 -0.77 1.241168E7 -605000.0 -0.34 1.195508E7 -700408.888888899 -0.411262491171785 -0.879 -0.9376 3562090 PK04_181250 CC(C)Cc1ccc(/C=C/C=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M19 compound treatment 1.31508E7 -715000.0 -0.4 1.269056E7 -326000.0 -0.18 1.207328E7 -582208.888888899 -0.341858422737388 -0.5353 -0.9585 3561852 PK04_181251 CCOC(=O)C1C2OC3(C=C2)C(N(C(=O)C13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M20 compound treatment 1.124148E7 -2620000.0 -1.47 1.0465E7 -2550000.0 -1.44 1.011116E7 -2544328.8888889 -1.49396595874838 -2.5429 -0.9999 3215597 PK04_181252 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4cc(C)cc(C)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M21 compound treatment 1.24216E7 -1440000.0 -0.81 1.216572E7 -851000.0 -0.48 1.169208E7 -963408.888888899 -0.565689479312617 -1.0715 -0.9751 3562092 PK04_181253 O=C1C2C3C(OC42C=CCN(Cc5ccccc5)C(=O)C4N1C6CCCCC6)C=CCOC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M22 compound treatment 1.181952E7 -2050000.0 -1.15 1.181272E7 -1200000.0 -0.68 1.119272E7 -1462768.8888889 -0.858901117327849 -1.5508 -0.9773 3562093 PK04_181254 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M23 compound treatment 1.063088E7 -3230000.0 -1.82 1.107352E7 -1940000.0 -1.09 1.018092E7 -2474568.8888889 -1.45300464052516 -2.5195 -0.98 3562094 PK04_181255 O=C1C2C3C4OC2(C=C4)C(N1C5CCCCC5)C(=O)N(Cc6ccccc6)CCCCOC3=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 M24 compound treatment 1.11624E7 -2700000.0 -1.52 1.076344E7 -2250000.0 -1.27 1.031356E7 -2341928.8888889 -1.37512176711452 -2.4029 -0.9973 3562095 PK04_181256 Cc1cc(C)cc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N01 compound treatment 1.403964E7 174000.0 0.1 1.04472E7 -2570000.0 -1.45 1.15742E7 -1081288.8888889 -0.634905651791862 -1.1453 -0.7236 3188533 PK04_181257 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N02 compound treatment 1.337356E7 -492000.0 -0.28 1.273788E7 -279000.0 -0.16 1.773736E7 5081871.1111111 2.98394695744788 1.4725 0.4907 3562096 PK04_181258 CC1(CCc2ccccc2)CC(C)(CC(=O)O)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N03 compound treatment 1.355204E7 -314000.0 -0.18 1.304384E7 26900.0 0.02 1.315952E7 504031.111111101 0.295954397027241 0.0779 0.226 3562097 PK04_181259 C=C/C=C/[C@H]1[C@@H]2[C@H](Cc3ccccc3)OC(=O)[C@H](Cc4ccccc4)N2CC1=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N04 compound treatment 1.249896E7 -1370000.0 -0.77 1.182744E7 -1190000.0 -0.67 1.178396E7 -871528.888888899 -0.511739853189501 -1.1252 -0.9871 3562099 PK04_181260 CC1(CCOCc2ccccc2)CC(C)(COCc3ccccc3)OO1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N05 compound treatment 1.255632E7 -1310000.0 -0.74 1.1428E7 -1590000.0 -0.89 1.220004E7 -455448.888888899 -0.267428137502666 -1.0954 -0.9217 3562100 PK04_181261 Cn1c(=O)n2[C@H]3[C@@H]4[C@H](Cc5ccccc5)OC(=O)[C@H](Cc6ccccc6)N4CC3=C[C@@H](C7CC7)n2c1=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N06 compound treatment 1.320096E7 -665000.0 -0.37 1.226956E7 -747000.0 -0.42 1.307228E7 416791.111111101 0.244729262253834 -0.3171 -0.517 3562102 PK04_181262 C[C@@H]1CCC[C@]2(CC(C)(CCOCc3ccccc3)OO2)C1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N07 compound treatment 1.399844E7 133000.0 0.07 1.347928E7 462000.0 0.26 1.33562E7 700711.111111101 0.41143994846275 0.4309 0.8748 3562104 PK04_181263 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3[C@H]1Cc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N08 compound treatment 1.431456E7 449000.0 0.25 1.38862E7 869000.0 0.49 1.411884E7 1463351.1111111 0.859242983579573 0.9242 0.9057 3562106 PK04_181264 CC1(C)O[C@]2(C)CC[C@@H]1OO2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N09 mock treatment 1.534024E7 1470000.0 0.83 1.41826E7 1170000.0 0.66 1.3143E7 487511.111111101 0.286254268342502 1.0223 0.9338 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N10 mock treatment 1.504396E7 1180000.0 0.66 1.47086E7 1690000.0 0.95 1.505868E7 2403191.1111111 1.41109340386201 1.7466 0.9563 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N11 compound treatment 1.26644E7 -1200000.0 -0.67 1.276424E7 -253000.0 -0.14 1.209E7 -565488.888888899 -0.332040859080678 -0.6634 -0.8668 3188666 PK04_181265 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N12 compound treatment 1.504756E7 1180000.0 0.66 1.576E7 2740000.0 1.54 1.64492E7 3793711.1111111 2.22757178998212 2.5609 0.9177 3562108 PK04_181266 CC[C@]1(CC[C@@H]2OO1)OC2(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N13 mock treatment 1.469416E7 829000.0 0.47 1.997792E7 6960000.0 3.92 1.86706E7 6015111.1111111 3.53192202365529 4.5701 0.863 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N14 mock treatment 1.557968E7 1710000.0 0.96 1.66432E7 3630000.0 2.04 1.3881E7 1225511.1111111 0.719589314912593 2.1498 0.9075 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N15 compound treatment 1.372296E7 -143000.0 -0.08 1.298804E7 -28900.0 -0.02 1.244484E7 -210648.888888899 -0.123687731811124 -0.1271 -0.8571 3188536 PK04_181267 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N16 compound treatment 1.362424E7 -241000.0 -0.14 1.392984E7 913000.0 0.51 1.387004E7 1214551.1111111 0.713153878448626 0.6301 0.7085 3562110 PK04_181268 CCC[C@]1(CC[C@@H]2OO1)OC2(C)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N17 compound treatment 1.35902E7 -275000.0 -0.15 1.318924E7 172000.0 0.1 1.24216E7 -233888.888888899 -0.137333675554063 -0.1126 -0.4929 3188535 PK04_181269 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N18 compound treatment 1.108236E7 -2780000.0 -1.56 1.208352E7 -933000.0 -0.53 1.085788E7 -1797608.8888889 -1.05551074740038 -1.8153 -0.9271 3562112 PK04_181270 CC1(C)O[C@]2(CCc3ccccc3)CC[C@@H]1OO2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N19 compound treatment 1.324432E7 -621000.0 -0.35 1.743628E7 4420000.0 2.49 1.205596E7 -599528.888888899 -0.352028291310009 1.0315 0.4067 3070940 PK04_181271 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N20 compound treatment 5452760.0 -8410000.0 -4.73 3828200.0 -9190000.0 -5.17 4975560.0 -7679928.8888889 -4.50946116899955 -8.318 -0.9984 3562114 PK04_181272 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N21 compound treatment 1.238084E7 -1480000.0 -0.83 1.234012E7 -677000.0 -0.38 1.14636E7 -1191888.8888889 -0.699847191291391 -1.1055 -0.9584 3188534 PK04_181273 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N22 compound treatment 576480.0 -1.33E7 -7.46 1.339048E7 373000.0 0.21 1.380872E7 1153231.1111111 0.677148316042558 -3.7971 -0.5064 3562115 PK04_181274 CC(C)(C)[C@H]1CC[C@]2(CC(C[Si](C)(C)C)OO2)CC1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N23 compound treatment 1.14376E7 -2430000.0 -1.36 1.071152E7 -2310000.0 -1.3 1.187084E7 -784648.888888899 -0.46072610136564 -1.8026 -0.9301 3562117 PK04_181275 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@H](C4CC4)n5n([C@@H]3[C@H]2[C@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 N24 compound treatment 1.227092E7 -1590000.0 -0.9 1.203204E7 -985000.0 -0.55 1.12146E7 -1440888.8888889 -0.846053731394308 -1.3257 -0.9812 1004341 PK04_181276 c1ccc2cnccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O01 compound treatment 1.16192E7 -2250000.0 -1.26 1.144028E7 -1580000.0 -0.89 1.183868E7 -816808.888888899 -0.47960964485845 -1.5178 -0.9395 3562118 PK04_181277 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)c4cccc(Cl)c4CO)C(=O)NCc5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O02 compound treatment 1.057632E7 -3290000.0 -1.85 1.00114E7 -3010000.0 -1.69 1.109316E7 -1562328.8888889 -0.917360246374622 -2.5731 -0.9645 3562120 PK04_181278 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O03 compound treatment 1.100364E7 -2860000.0 -1.61 1.029748E7 -2720000.0 -1.53 1.321652E7 561031.111111101 0.329423364038752 -1.6217 -0.7227 3562122 PK04_181279 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O04 compound treatment 8688880.0 -5180000.0 -2.91 8379000.0 -4640000.0 -2.61 8447920.0 -4207568.8888889 -2.47057867264707 -4.6125 -0.9977 3562124 PK04_181280 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O05 compound treatment 1.2826E7 -1040000.0 -0.58 1.441028E7 1390000.0 0.78 1.162148E7 -1034008.8888889 -0.607144024418103 -0.2348 -0.204 3562122 PK04_181281 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O06 compound treatment 1.014748E7 -3720000.0 -2.09 9972000.0 -3040000.0 -1.71 9496280.0 -3159208.8888889 -1.8550080365736 -3.2663 -0.9967 3562126 PK04_181282 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4cc(C)cc(C)c4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O07 compound treatment 9448120.0 -4420000.0 -2.48 7963920.0 -5050000.0 -2.84 7689800.0 -4965688.8888889 -2.91572767739737 -4.7582 -0.9976 3562128 PK04_181283 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O08 compound treatment 8566680.0 -5300000.0 -2.98 9639880.0 -3380000.0 -1.9 8455360.0 -4200128.8888889 -2.46621009168978 -4.2398 -0.9843 3215600 PK04_181284 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O09 compound treatment 7962880.0 -5900000.0 -3.32 7800400.0 -5220000.0 -2.94 7198680.0 -5456808.8888889 -3.20410099456743 -5.4594 -0.9987 3562128 PK04_181285 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O10 compound treatment 1.393112E7 65500.0 0.04 1.338736E7 370000.0 0.21 1.369408E7 1038591.1111111 0.609834590109231 0.4937 0.7648 3562130 PK04_181286 OCCSCC(O)CC(O)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O11 mock treatment 1.344364E7 -422000.0 -0.24 1.33056E7 289000.0 0.16 1.277788E7 122391.111111101 0.0718649835136777 -0.0015 -0.0052 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O12 mock treatment 1.478624E7 921000.0 0.52 1.370328E7 686000.0 0.39 1.407684E7 1421351.1111111 0.834581639465828 1.0034 0.9511 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O13 compound treatment 1.410132E7 236000.0 0.13 1.412708E7 1110000.0 0.62 1.17684E7 -887088.888888899 -0.520876294008784 0.1365 0.1656 3561848 PK04_181287 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O14 compound treatment 1.46546E7 789000.0 0.44 1.348044E7 463000.0 0.26 1.703996E7 4384471.1111111 2.57445121018774 1.8928 0.721 3562131 PK04_181288 OC(CSc1ccncc1)CC(O)c2ccccc2 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O15 compound treatment 1.269776E7 -1170000.0 -0.66 1.257004E7 -447000.0 -0.25 1.222936E7 -426128.888888899 -0.250212170611833 -0.6684 -0.8963 3562132 PK04_181289 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O16 compound treatment 1.389056E7 25000.0 0.01 1.298252E7 -34500.0 -0.02 1.319824E7 542751.111111101 0.318689807600675 0.1809 0.566 3562134 PK04_181290 COC(=O)CCCCCCC(=O)Nc1ccc(C=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O17 compound treatment 1.2235E7 -1630000.0 -0.92 1.23336E7 -683000.0 -0.38 1.201112E7 -644368.888888899 -0.378357212025731 -0.9693 -0.9119 3562132 PK04_181291 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O18 compound treatment 1.324348E7 -622000.0 -0.35 1.292548E7 -91500.0 -0.05 1.202844E7 -627048.888888899 -0.36818734345311 -0.4441 -0.8703 3562135 PK04_181292 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccccn3)CC(O2)c4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O19 compound treatment 9946800.0 -3920000.0 -2.2 1.080328E7 -2210000.0 -1.25 9942840.0 -2712648.8888889 -1.59279923115851 -2.9099 -0.9735 3561921 PK04_181293 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O20 compound treatment 1.227584E7 -1590000.0 -0.89 1.25742E7 -443000.0 -0.25 1.204152E7 -613968.888888899 -0.360507096286258 -0.8676 -0.8722 3562136 PK04_181294 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc4ccccc4s3)CC(O2)c5ccccc5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O21 compound treatment 1.099492E7 -2870000.0 -1.61 1.115696E7 -1860000.0 -1.05 1.111932E7 -1536168.8888889 -0.901999752040918 -2.0562 -0.9683 3561921 PK04_181295 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O22 compound treatment 1.087808E7 -2990000.0 -1.68 1.143508E7 -1580000.0 -0.89 1.12782E7 -1377288.8888889 -0.80870941030778 -1.9498 -0.9444 3562137 PK04_181296 OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O23 compound treatment 1.069492E7 -3170000.0 -1.78 1.087572E7 -2140000.0 -1.21 1.097152E7 -1683968.8888889 -0.988784196326907 -2.295 -0.9696 3561921 PK04_181297 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 O24 compound treatment 9120720.0 -4740000.0 -2.67 9645560.0 -3370000.0 -1.9 9438880.0 -3216608.8888889 -1.88871187352906 -3.7248 -0.986 3562138 PK04_181298 CC(C)(C)OC(=O)OC(CC=C)c1ccccc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P01 compound treatment 7676040.0 -6190000.0 -3.48 7139080.0 -5880000.0 -3.31 7595920.0 -5059568.8888889 -2.97085165324019 -5.6327 -0.9979 3562139 PK04_181299 COC(=O)C1(CCCCC1)N2CC3=CCCC=C[C@H]3[C@@H]2[C@@H](O)Cc4ccccc4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P02 compound treatment 1.146548E7 -2400000.0 -1.35 9948120.0 -3070000.0 -1.73 1.171708E7 -938408.888888899 -0.551010107816341 -2.0938 -0.9267 1015751 PK04_181300 Cc1ccncc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P03 compound treatment 1.204936E7 -1820000.0 -1.02 1.14902E7 -1530000.0 -0.86 1.059176E7 -2063728.8888889 -1.21176972110395 -1.7848 -0.9904 3562141 PK04_181301 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N(CC#C)[C@H](/C=C/C3CC3)[C@@H](O)Cc4ccccc4)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P04 compound treatment 1.18658E7 -2000000.0 -1.12 1.084792E7 -2170000.0 -1.22 1.15316E7 -1123888.8888889 -0.659919300821518 -1.7344 -0.9714 3562143 PK04_181302 COc1cc2CCN(=Cc2cc1OC)Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P05 compound treatment 1.173636E7 -2130000.0 -1.2 1.230688E7 -710000.0 -0.4 1.245648E7 -199008.888888899 -0.116853016442457 -0.9887 -0.7807 3562144 PK04_181303 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=CCCC=C[C@H]4[C@@H]3[C@@H](O)Cc5ccccc5)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P06 compound treatment 1.148508E7 -2380000.0 -1.34 1.233956E7 -677000.0 -0.38 1.157308E7 -1082408.8888889 -0.635563287634895 -1.3591 -0.889 1024512 PK04_181304 COc1cc2CCN=C(C)c2cc1OC 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P07 compound treatment 9673360.0 -4190000.0 -2.35 9802040.0 -3210000.0 -1.81 9308360.0 -3347128.8888889 -1.96534993623682 -3.539 -0.9938 3562146 PK04_181305 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3C51CCCCC5 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P08 compound treatment 1.20082E7 -1860000.0 -1.04 1.143276E7 -1580000.0 -0.89 1.274744E7 91951.1111111008 0.053991380779811 -1.086 -0.7907 3562148 PK04_181306 COc1cc2CC(C)N(=Cc2cc1OC)Cl 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P09 compound treatment 1.278344E7 -1080000.0 -0.61 1.241232E7 -605000.0 -0.34 1.262828E7 -27208.8888888992 -0.0159763755200428 -0.5567 -0.7989 3562149 PK04_181307 COC(=O)C1(CCCC1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P10 compound treatment 1.31746E7 -691000.0 -0.39 1.258488E7 -432000.0 -0.24 1.207732E7 -578168.888888899 -0.33948623630359 -0.5605 -0.9831 1003512 PK04_181308 C[n+]1ccc2ccccc2c1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P11 mock treatment 1.319528E7 -670000.0 -0.38 1.302312E7 6140.0 0.0 1.262736E7 -28128.8888888992 -0.0165165763911058 -0.2249 -0.5968 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P12 mock treatment 1.361468E7 -251000.0 -0.14 1.24982E7 -519000.0 -0.29 1.225784E7 -397648.888888899 -0.233489430603274 -0.3848 -0.963 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P13 compound treatment 1.069384E7 -3170000.0 -1.78 1.094936E7 -2070000.0 -1.16 1.100536E7 -1650128.8888889 -0.968914199069546 -2.2599 -0.9665 3562151 PK04_181309 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3C[C@](C)(OC)O[C@@H](Cc4ccccc4)[C@H]3/C=C/C5CC5)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P14 compound treatment 1.261636E7 -1250000.0 -0.7 1.237128E7 -646000.0 -0.36 1.223896E7 -416528.888888899 -0.244575291957263 -0.7562 -0.9141 1009497 PK04_181310 Cc1cc[n+](C)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P15 compound treatment 9636400.0 -4230000.0 -2.38 1.02602E7 -2760000.0 -1.55 1.022928E7 -2426208.8888889 -1.42460886430277 -3.0899 -0.9732 3562153 PK04_181311 COC(=O)[C@@H]1N[C@H](SC1(C)C)[C@@H]2N(CC#C)[C@H](/C=C/C3CC3)[C@H](Cc4ccccc4)OC2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P16 compound treatment 1.246956E7 -1400000.0 -0.78 1.192484E7 -1090000.0 -0.61 1.125144E7 -1404048.8888889 -0.824422209557394 -1.2836 -0.9926 1023898 PK04_181312 COc1cc2CC[N+](=Cc2cc1OC)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P17 compound treatment 1.146568E7 -2400000.0 -1.35 1.068892E7 -2330000.0 -1.31 1.110304E7 -1552448.8888889 -0.911558958759293 -2.0612 -0.9865 3562155 PK04_181313 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC(=C[C@@H]3[C@@H](O)Cc4ccccc4)/C=C/C5CC5)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P18 compound treatment 1.2384E7 -1480000.0 -0.83 1.232352E7 -693000.0 -0.39 1.186236E7 -793128.888888899 -0.465705344177177 -0.9747 -0.9459 1071838 PK04_181314 COc1cc2CC[N+](=C(C)c2cc1OC)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P19 compound treatment 1.112588E7 -2740000.0 -1.54 1.077316E7 -2240000.0 -1.26 1.091868E7 -1736808.8888889 -1.01981051592144 -2.2065 -0.9864 3562157 PK04_181315 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)C41CCCC4 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P20 compound treatment 1.152728E7 -2340000.0 -1.31 1.087344E7 -2140000.0 -1.21 1.085352E7 -1801968.8888889 -1.05807082978933 -2.0658 -0.9962 1023900 PK04_181316 COc1cc2CC(C)[N+](=Cc2cc1OC)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P21 compound treatment 1.22146E7 -1650000.0 -0.93 1.138524E7 -1630000.0 -0.92 1.16032E7 -1052288.8888889 -0.617877580856181 -1.4224 -0.985 3562159 PK04_181317 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=C[C@@H](C5CC5)n6n(C4[C@@H]3[C@@H](O)Cc7ccccc7)c(=O)n(C)c6=O)C2=O 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P22 compound treatment 1.030864E7 -3560000.0 -2.0 1.070972E7 -2310000.0 -1.3 1.038236E7 -2273128.8888889 -1.33472413675676 -2.6739 -0.979 1107245 PK04_181318 COc1ccc(C[n+]2ccc3ccccc3c2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P23 compound treatment 1.023732E7 -3630000.0 -2.04 1.030568E7 -2710000.0 -1.53 9977320.0 -2678168.8888889 -1.57255344199084 -2.9657 -0.991 3562161 PK04_181319 CC(=CCc1cc(/C=C/2\OC(=O)C(=C2O)c3cc4CCC(C)(C)Oc4cc3O)ccc1O)C 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.2181 P24 compound treatment 8399080.0 -5470000.0 -3.07 8178120.0 -4840000.0 -2.72 6467440.0 -6188048.8888889 -3.63346673908493 -5.4431 -0.993 3562163 PK04_181320 COc1ccc(C[n+]2ccc(C)cc2)cc1 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A01 mock treatment 8899800.0 -3010000.0 -1.69 9559080.0 -4000000.0 -2.25 9833640.0 -3067243.0687831 -1.80100801904189 -3.3187 -0.9921 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A02 mock treatment 9944240.0 -1970000.0 -1.11 1.08778E7 -2690000.0 -1.51 1.084596E7 -2054923.0687831 -1.20659916491745 -2.2082 -0.991 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A03 mock treatment 1.073116E7 -1180000.0 -0.66 1.147336E7 -2090000.0 -1.18 1.128824E7 -1612643.0687831 -0.946903467902521 -1.6095 -0.9756 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A04 mock treatment 1.050164E7 -1410000.0 -0.79 1.195416E7 -1610000.0 -0.91 1.162756E7 -1273323.0687831 -0.747663294457855 -1.4127 -0.9967 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A05 mock treatment 1.100992E7 -904000.0 -0.51 1.208092E7 -1480000.0 -0.83 1.183204E7 -1068843.0687831 -0.627597779115508 -1.1373 -0.9796 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A06 mock treatment 1.125768E7 -657000.0 -0.37 1.19928E7 -1570000.0 -0.88 1.237296E7 -527923.068783101 -0.309983153924866 -0.9023 -0.8963 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A07 mock treatment 1.077948E7 -1130000.0 -0.64 1.224984E7 -1310000.0 -0.74 1.164232E7 -1258563.0687831 -0.738996593526454 -1.2215 -0.9977 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A08 mock treatment 1.10248E7 -890000.0 -0.5 1.244728E7 -1120000.0 -0.63 1.222296E7 -677923.068783101 -0.398059382902527 -0.8809 -0.9833 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A09 mock treatment 1.098988E7 -925000.0 -0.52 1.234096E7 -1220000.0 -0.69 1.208612E7 -814763.068783101 -0.478408390724547 -0.9732 -0.9872 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A10 mock treatment 1.1099E7 -815000.0 -0.46 1.286076E7 -702000.0 -0.4 1.206856E7 -832323.068783101 -0.488719181263532 -0.7748 -0.9962 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A11 mock treatment 1.123852E7 -676000.0 -0.38 1.265332E7 -910000.0 -0.51 1.218388E7 -717003.068783101 -0.421006176425506 -0.7579 -0.9921 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A12 mock treatment 1.108716E7 -827000.0 -0.46 1.214936E7 -1410000.0 -0.8 1.179704E7 -1103843.0687831 -0.648148899210296 -1.1019 -0.9781 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A13 mock treatment 1.106484E7 -850000.0 -0.48 1.235272E7 -1210000.0 -0.68 1.219564E7 -705243.068783101 -0.414101000073658 -0.9079 -0.9771 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A14 mock treatment 1.039104E7 -1520000.0 -0.86 1.24474E7 -1120000.0 -0.63 1.221376E7 -687123.068783101 -0.403461391613156 -1.0895 -0.9595 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A15 mock treatment 1.08344E7 -1080000.0 -0.61 1.20278E7 -1540000.0 -0.86 1.19464E7 -954483.068783101 -0.560448462142939 -1.1727 -0.9811 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A16 mock treatment 1.112712E7 -787000.0 -0.44 1.211452E7 -1450000.0 -0.82 1.20084E7 -892483.068783101 -0.524043620832173 -1.0286 -0.9655 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A17 mock treatment 1.09878E7 -927000.0 -0.52 1.259116E7 -972000.0 -0.55 1.134156E7 -1559323.0687831 -0.915595304375262 -1.145 -0.9647 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A18 mock treatment 1.07174E7 -1200000.0 -0.67 1.219908E7 -1360000.0 -0.77 1.162928E7 -1271603.0687831 -0.746653353698912 -1.2625 -0.9984 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A19 mock treatment 1.067004E7 -1240000.0 -0.7 1.18976E7 -1670000.0 -0.94 1.152924E7 -1371643.0687831 -0.805394326678413 -1.4098 -0.9929 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A20 mock treatment 1.091216E7 -1000000.0 -0.56 1.207784E7 -1490000.0 -0.84 1.138256E7 -1518323.0687831 -0.891521135121368 -1.3224 -0.9828 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A21 mock treatment 9808560.0 -2110000.0 -1.18 1.114312E7 -2420000.0 -1.36 1.115052E7 -1750363.0687831 -1.02776918960121 -2.0627 -0.9935 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A22 mock treatment 1.021624E7 -1700000.0 -0.95 1.056804E7 -2990000.0 -1.69 1.07756E7 -2125283.0687831 -1.24791278805658 -2.2445 -0.9741 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A23 mock treatment 9568760.0 -2350000.0 -1.32 9791440.0 -3770000.0 -2.12 9700680.0 -3200203.0687831 -1.87907878840769 -3.0713 -0.9824 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base A24 mock treatment 7872920.0 -4040000.0 -2.27 8433160.0 -5130000.0 -2.89 7714040.0 -5186843.0687831 -3.04558385198223 -4.7362 -0.9926 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B01 mock treatment 1.123044E7 -684000.0 -0.38 1.152804E7 -2030000.0 -1.15 1.162344E7 -1277443.0687831 -0.750082454880442 -1.3162 -0.9255 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B02 mock treatment 1.153292E7 -381000.0 -0.21 1.244712E7 -1120000.0 -0.63 1.289312E7 -7763.06878310069 -0.00455827882473139 -0.489 -0.7368 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B03 mock treatment 1.184524E7 -69200.0 -0.04 1.290284E7 -660000.0 -0.37 1.245064E7 -450243.068783101 -0.264371410811634 -0.3896 -0.8512 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B04 mock treatment 1.189068E7 -23700.0 -0.01 1.364084E7 77800.0 0.04 1.297276E7 71876.9312168993 0.0422043270138081 0.042 0.6738 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B05 mock treatment 1.183228E7 -82100.0 -0.05 1.295676E7 -606000.0 -0.34 1.275224E7 -148643.068783101 -0.0872794730805506 -0.2741 -0.7714 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B06 mock treatment 1.093348E7 -981000.0 -0.55 1.362004E7 57000.0 0.03 1.338296E7 482076.931216899 0.283063454524718 -0.1361 -0.2195 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B07 mock treatment 1.174304E7 -171000.0 -0.1 1.322852E7 -334000.0 -0.19 1.311776E7 216876.931216899 0.127344681692214 -0.0908 -0.3677 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B08 mock treatment 1.183548E7 -78900.0 -0.04 1.36978E7 135000.0 0.08 1.309064E7 189756.931216899 0.111420499493053 0.0825 0.5816 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B09 mock treatment 1.221284E7 298000.0 0.17 1.394688E7 384000.0 0.22 1.346144E7 560556.931216899 0.32914493752583 0.4116 0.9618 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B10 mock treatment 1.242652E7 512000.0 0.29 1.423512E7 672000.0 0.38 1.38686E7 967716.931216899 0.568219053462793 0.7126 0.9619 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B11 mock treatment 1.219468E7 280000.0 0.16 1.428168E7 719000.0 0.4 1.316004E7 259156.931216899 0.152170434766717 0.4123 0.8963 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B12 mock treatment 1.243604E7 522000.0 0.29 1.440504E7 842000.0 0.47 1.356188E7 660996.931216899 0.388120780449272 0.6669 0.9821 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B13 mock treatment 1.227688E7 362000.0 0.2 1.441884E7 856000.0 0.48 1.299088E7 89996.9312168993 0.0528439354743095 0.4262 0.8108 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B14 mock treatment 1.20388E7 124000.0 0.07 1.457936E7 1020000.0 0.57 1.365632E7 755436.931216899 0.443573574213608 0.6267 0.8617 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B15 mock treatment 1.2007E7 92600.0 0.05 1.405272E7 490000.0 0.28 1.272636E7 -174523.068783101 -0.102475558453496 0.13 0.4353 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B16 mock treatment 1.195576E7 41300.0 0.02 1.379112E7 228000.0 0.13 1.31892E7 288316.931216899 0.169292453679974 0.1853 0.8668 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B17 mock treatment 1.187576E7 -38700.0 -0.02 1.35128E7 -50200.0 -0.03 1.281892E7 -81963.0687831007 -0.048126653425681 -0.0566 -0.9458 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B18 mock treatment 1.152512E7 -389000.0 -0.22 1.385756E7 295000.0 0.17 1.308172E7 180836.931216899 0.106182899743181 0.0308 0.1046 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B19 mock treatment 1.165696E7 -257000.0 -0.14 1.343296E7 -130000.0 -0.07 1.331604E7 415156.931216899 0.243769712903484 0.015 0.0512 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B20 mock treatment 1.225168E7 337000.0 0.19 1.33406E7 -222000.0 -0.13 1.322572E7 324836.931216899 0.190736079561735 0.1472 0.4964 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B21 mock treatment 1.151532E7 -399000.0 -0.22 1.285096E7 -712000.0 -0.4 1.269704E7 -203843.068783101 -0.11969152534433 -0.4299 -0.9059 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B22 mock treatment 1.097264E7 -942000.0 -0.53 1.258968E7 -973000.0 -0.55 1.145528E7 -1445603.0687831 -0.848821779312998 -1.1118 -0.9749 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B23 mock treatment 1.07452E7 -1170000.0 -0.66 1.1865E7 -1700000.0 -0.96 1.210312E7 -797763.068783101 -0.468426418107079 -1.2015 -0.9606 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base B24 mock treatment 9305760.0 -2610000.0 -1.47 1.036088E7 -3200000.0 -1.8 1.047672E7 -2424163.0687831 -1.42340761016886 -2.7084 -0.9942 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C01 mock treatment 1.0695E7 -1220000.0 -0.68 1.176312E7 -1800000.0 -1.01 1.208064E7 -820243.068783101 -0.481626108956531 -1.2585 -0.9575 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C02 mock treatment 1.16056E7 -309000.0 -0.17 1.310032E7 -463000.0 -0.26 1.240244E7 -498443.068783101 -0.292673239056456 -0.4195 -0.9791 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C03 mock treatment 1.156832E7 -346000.0 -0.19 1.318408E7 -379000.0 -0.21 1.279344E7 -107443.068783101 -0.0630878688546864 -0.2718 -0.9201 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C04 mock treatment 1.210704E7 193000.0 0.11 1.357764E7 14600.0 0.01 1.344708E7 546196.931216899 0.320713106538369 0.2524 0.7454 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C05 mock treatment 1.212184E7 207000.0 0.12 1.38412E7 278000.0 0.16 1.29702E7 69316.9312168993 0.0407011593725893 0.1812 0.9087 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C06 mock treatment 1.211452E7 200000.0 0.11 1.446444E7 901000.0 0.51 1.394348E7 1042596.9312169 0.612186706968442 0.7113 0.8857 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C07 mock treatment 1.296048E7 1050000.0 0.59 1.45272E7 964000.0 0.54 1.341388E7 512996.931216899 0.301218901191313 0.8265 0.967 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C08 mock treatment 1.226512E7 351000.0 0.2 1.429332E7 730000.0 0.41 1.377768E7 876796.931216899 0.514833115205134 0.6483 0.9428 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C09 mock treatment 1.210412E7 190000.0 0.11 1.39358E7 373000.0 0.21 1.315808E7 257196.931216899 0.151019572041409 0.2699 0.9651 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C10 mock treatment 1.221472E7 300000.0 0.17 1.413704E7 574000.0 0.32 1.341884E7 517956.931216899 0.304131288496175 0.4595 0.968 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C11 mock treatment 1.210748E7 193000.0 0.11 1.422688E7 664000.0 0.37 1.321988E7 318996.931216899 0.187306978380205 0.3865 0.895 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C12 mock treatment 1.272996E7 816000.0 0.46 1.463188E7 1070000.0 0.6 1.360788E7 706996.931216899 0.415130824002422 0.8515 0.9871 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C13 mock treatment 1.212888E7 214000.0 0.12 1.48316E7 1270000.0 0.71 1.420184E7 1300956.9312169 0.763889203759565 0.9229 0.8767 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C14 mock treatment 1.248524E7 571000.0 0.32 1.402288E7 460000.0 0.26 1.35012E7 600316.931216899 0.352491009953509 0.5381 0.9923 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C15 mock treatment 1.211628E7 202000.0 0.11 1.373036E7 167000.0 0.09 1.329668E7 395796.931216899 0.232402007616768 0.254 0.923 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C16 mock treatment 1.220476E7 290000.0 0.16 1.43552E7 792000.0 0.45 1.28448E7 -56083.0687831007 -0.0329305680527352 0.3326 0.6988 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C17 mock treatment 1.19694E7 55000.0 0.03 1.385792E7 295000.0 0.17 1.29922E7 91316.9312168993 0.0536190062893129 0.1446 0.8164 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C18 mock treatment 1.249172E7 577000.0 0.32 1.390592E7 343000.0 0.19 1.288716E7 -13723.0687831007 -0.00805784098944379 0.294 0.7789 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C19 mock treatment 1.175772E7 -157000.0 -0.09 1.35024E7 -60600.0 -0.03 1.346476E7 563876.931216899 0.331094358060536 0.1206 0.3504 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C20 mock treatment 1.166828E7 -246000.0 -0.14 1.357032E7 7320.0 0.0 1.250916E7 -391723.068783101 -0.230009938013149 -0.2102 -0.7833 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C21 mock treatment 1.140064E7 -514000.0 -0.29 1.283592E7 -727000.0 -0.41 1.255912E7 -341763.068783101 -0.20067468201499 -0.5188 -0.9616 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C22 mock treatment 1.117164E7 -743000.0 -0.42 1.309616E7 -467000.0 -0.26 1.239968E7 -501203.068783101 -0.294293841669645 -0.5625 -0.9796 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C23 mock treatment 1.05314E7 -1380000.0 -0.78 1.271264E7 -850000.0 -0.48 1.182884E7 -1072043.0687831 -0.629476738667031 -1.0883 -0.9817 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base C24 mock treatment 1.129228E7 -622000.0 -0.35 1.22372E7 -1330000.0 -0.75 1.049936E7 -2401523.0687831 -1.41011397134184 -1.4468 -0.8858 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D01 mock treatment 1.10774E7 -837000.0 -0.47 1.294948E7 -614000.0 -0.35 1.294236E7 41476.9312168993 0.0243542112743354 -0.4568 -0.7823 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D02 mock treatment 1.181708E7 -97300.0 -0.05 1.299308E7 -570000.0 -0.32 1.34528E7 551916.931216899 0.324071746736717 -0.0297 -0.0646 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D03 mock treatment 1.339496E7 1480000.0 0.83 1.469532E7 1130000.0 0.64 1.292476E7 23876.9312168993 0.0140199337409566 0.8562 0.8171 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D04 mock treatment 1.213096E7 217000.0 0.12 1.374396E7 181000.0 0.1 1.288248E7 -18403.0687831007 -0.0108058193335468 0.1228 0.7722 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D05 mock treatment 1.23674E7 453000.0 0.25 1.371068E7 148000.0 0.08 1.26714E7 -229483.068783101 -0.134746688750911 0.1171 0.3907 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D06 mock treatment 1.267992E7 766000.0 0.43 1.425784E7 695000.0 0.39 1.374428E7 843396.931216899 0.495221474886108 0.76 0.9952 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D07 mock treatment 1.40846E7 2170000.0 1.22 1.54718E7 1910000.0 1.07 1.35746E7 673716.931216899 0.395589644666578 1.5525 0.9283 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D08 mock treatment 1.214352E7 229000.0 0.13 1.3934E7 371000.0 0.21 1.31036E7 202716.931216899 0.119030285676722 0.2636 0.9668 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D09 mock treatment 1.259608E7 682000.0 0.38 1.418172E7 619000.0 0.35 1.366756E7 766676.931216899 0.450173419638334 0.682 0.9943 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D10 mock treatment 1.28728E7 958000.0 0.54 1.474504E7 1180000.0 0.67 1.34016E7 500716.931216899 0.294008393912342 0.8647 0.9555 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D11 mock treatment 1.216484E7 250000.0 0.14 1.385236E7 289000.0 0.16 1.3952E7 1051116.9312169 0.617189436774373 0.5316 0.8133 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D12 mock treatment 1.315008E7 1240000.0 0.69 1.435484E7 792000.0 0.45 1.376776E7 866876.931216899 0.509008340595411 0.9519 0.9821 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D13 mock treatment 1.239564E7 481000.0 0.27 1.529088E7 1730000.0 0.97 1.426492E7 1364036.9312169 0.800928193918971 1.18 0.9157 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D14 mock treatment 1.460096E7 2690000.0 1.51 1.469248E7 1130000.0 0.64 1.363004E7 729156.931216899 0.428142618896721 1.4855 0.8777 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D15 mock treatment 1.180648E7 -108000.0 -0.06 1.423272E7 670000.0 0.38 1.340132E7 500436.931216899 0.293843984951584 0.3523 0.7312 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D16 mock treatment 1.19364E7 22000.0 0.01 1.423924E7 676000.0 0.38 1.27358E7 -165083.068783101 -0.0969326277765022 0.1709 0.435 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D17 mock treatment 1.205096E7 137000.0 0.08 1.41486E7 586000.0 0.33 1.287572E7 -25163.0687831007 -0.0147751213861401 0.2261 0.6673 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D18 mock treatment 1.203712E7 123000.0 0.07 1.451784E7 955000.0 0.54 1.312584E7 224956.931216899 0.13208905455981 0.4264 0.7644 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D19 mock treatment 1.247732E7 563000.0 0.32 1.36742E7 111000.0 0.06 1.322588E7 324996.931216899 0.190830027539312 0.3289 0.878 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D20 mock treatment 1.244224E7 528000.0 0.3 1.31832E7 -380000.0 -0.21 1.227484E7 -626043.068783101 -0.367596751173453 -0.1645 -0.3173 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D21 mock treatment 1.152476E7 -390000.0 -0.22 1.329388E7 -269000.0 -0.15 1.254532E7 -355563.068783101 -0.208777695080935 -0.3344 -0.9884 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D22 mock treatment 1.113624E7 -778000.0 -0.44 1.299676E7 -566000.0 -0.32 1.309772E7 196836.931216899 0.115577697500798 -0.3697 -0.6682 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D23 mock treatment 1.077516E7 -1140000.0 -0.64 1.258348E7 -980000.0 -0.55 1.19E7 -1000883.0687831 -0.587693375640029 -1.0271 -0.9981 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base D24 mock treatment 9936080.0 -1980000.0 -1.11 1.15514E7 -2010000.0 -1.13 1.101036E7 -1890523.0687831 -1.11006761795794 -1.9362 -1.0 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E01 mock treatment 1.166096E7 -253000.0 -0.14 1.086084E7 -2700000.0 -1.52 1.204604E7 -854843.068783101 -0.501942359107378 -1.2502 -0.7774 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E02 mock treatment 1.147456E7 -440000.0 -0.25 1.311672E7 -446000.0 -0.25 1.31528E7 251916.931216899 0.147919288781395 -0.2023 -0.5293 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E03 mock treatment 1.161036E7 -304000.0 -0.17 1.342136E7 -142000.0 -0.08 1.3116E7 215116.931216899 0.126311253938876 -0.0717 -0.3161 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E04 mock treatment 1.232344E7 409000.0 0.23 1.437852E7 816000.0 0.46 1.33394E7 438516.931216899 0.257486117629605 0.5463 0.9513 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E05 mock treatment 1.194056E7 26100.0 0.01 1.362276E7 59800.0 0.03 1.291568E7 14796.9312168993 0.00868838601350882 0.0329 0.8727 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E06 mock treatment 1.239196E7 478000.0 0.27 1.386596E7 303000.0 0.17 1.311752E7 216636.931216899 0.127203759725849 0.3268 0.9544 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E07 mock treatment 1.249512E7 581000.0 0.33 1.427544E7 712000.0 0.4 1.35226E7 621716.931216899 0.365056551954322 0.6306 0.9965 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E08 mock treatment 1.288376E7 969000.0 0.54 1.419228E7 629000.0 0.35 1.373308E7 832196.931216899 0.488645116455776 0.801 0.9854 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E09 mock treatment 1.249772E7 583000.0 0.33 1.465904E7 1100000.0 0.62 1.316792E7 267036.931216899 0.156797372662343 0.6359 0.8882 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E10 mock treatment 1.222544E7 311000.0 0.17 1.456576E7 1000000.0 0.56 1.356152E7 660636.931216899 0.387909397499726 0.6507 0.9206 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E11 mock treatment 1.218184E7 267000.0 0.15 1.43182E7 755000.0 0.43 1.267672E7 -224163.068783101 -0.131622918496504 0.2562 0.5454 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E12 mock treatment 1.259168E7 677000.0 0.38 1.421448E7 651000.0 0.37 1.369252E7 791636.931216899 0.464829304140216 0.6997 0.9943 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E13 mock treatment 1.24768E7 562000.0 0.32 1.467284E7 1110000.0 0.62 1.663696E7 3736076.9312169 2.19373044848011 1.8096 0.7859 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E14 mock treatment 1.244972E7 535000.0 0.3 1.425992E7 697000.0 0.39 1.333088E7 429996.931216899 0.252483387823674 0.5459 0.9835 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E15 mock treatment 1.224968E7 335000.0 0.19 1.401872E7 456000.0 0.26 1.32386E7 337716.931216899 0.198298891756617 0.3713 0.9903 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E16 mock treatment 1.221908E7 305000.0 0.17 1.405544E7 492000.0 0.28 1.338756E7 486676.931216899 0.285764458880033 0.4238 0.978 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E17 mock treatment 1.171292E7 -201000.0 -0.11 1.40538E7 491000.0 0.28 1.315164E7 250756.931216899 0.147238165943968 0.1792 0.5382 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E18 mock treatment 1.17298E7 -185000.0 -0.1 1.34364E7 -127000.0 -0.07 1.301108E7 110196.931216899 0.0647048676433012 -0.0637 -0.4499 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E19 mock treatment 1.236956E7 455000.0 0.26 1.48968E7 1330000.0 0.75 1.463008E7 1729196.9312169 1.01534096574219 1.1673 0.906 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E20 mock treatment 1.156968E7 -345000.0 -0.19 1.314148E7 -422000.0 -0.24 1.231176E7 -589123.068783101 -0.345918255347751 -0.4485 -0.9708 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E21 mock treatment 1.111108E7 -803000.0 -0.45 1.29614E7 -602000.0 -0.34 1.232552E7 -575363.068783101 -0.3378387292762 -0.6511 -0.9901 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E22 mock treatment 1.142576E7 -489000.0 -0.27 1.290472E7 -658000.0 -0.37 1.201648E7 -884403.068783101 -0.519299247964576 -0.6722 -0.9679 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E23 mock treatment 1.1014E7 -900000.0 -0.51 1.293868E7 -624000.0 -0.35 1.243544E7 -465443.068783101 -0.27329646868137 -0.6527 -0.9687 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base E24 mock treatment 1.092864E7 -986000.0 -0.55 1.289788E7 -665000.0 -0.37 1.154568E7 -1355203.0687831 -0.795741171982461 -0.9953 -0.9577 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F01 mock treatment 1.110008E7 -814000.0 -0.46 1.261736E7 -946000.0 -0.53 1.263136E7 -269523.068783101 -0.158257170139348 -0.6628 -0.9212 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F02 mock treatment 1.210708E7 193000.0 0.11 1.377552E7 213000.0 0.12 1.315808E7 257196.931216899 0.151019572041409 0.2187 0.9899 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F03 mock treatment 1.167496E7 -239000.0 -0.13 1.370256E7 140000.0 0.08 1.269028E7 -210603.068783101 -0.123660827396923 -0.1037 -0.5214 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F04 mock treatment 1.236048E7 446000.0 0.25 1.343872E7 -124000.0 -0.07 1.289368E7 -7203.06878310069 -0.00422946090321479 0.1018 0.3914 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F05 mock treatment 1.195788E7 43500.0 0.02 1.354232E7 -20700.0 -0.01 1.33802E7 479316.931216899 0.281442851911529 0.1699 0.6008 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F06 mock treatment 1.279936E7 885000.0 0.5 1.48084E7 1250000.0 0.7 1.493976E7 2038876.9312169 1.19717727634087 1.3829 0.9384 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F07 mock treatment 1.218868E7 274000.0 0.15 1.411664E7 554000.0 0.31 1.377932E7 878436.931216899 0.515796081975289 0.5667 0.911 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F08 mock treatment 1.262488E7 710000.0 0.4 1.427036E7 707000.0 0.4 1.378492E7 884036.931216899 0.519084261190456 0.76 0.9917 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F09 mock treatment 1.217896E7 265000.0 0.15 1.395732E7 394000.0 0.22 1.384588E7 944996.931216899 0.554878440646977 0.5343 0.8676 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F10 mock treatment 1.276408E7 850000.0 0.48 1.450776E7 945000.0 0.53 1.361996E7 719076.931216899 0.422223896309423 0.8263 0.9956 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F11 mock treatment 1.267848E7 764000.0 0.43 1.50704E7 1510000.0 0.85 1.189344E7 -1007443.0687831 -0.591545242720652 0.3961 0.3537 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F12 mock treatment 1.291912E7 1000000.0 0.56 1.616332E7 2600000.0 1.46 1.422888E7 1327996.9312169 0.779766411969938 1.6211 0.9254 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F13 mock treatment 1.24424E7 528000.0 0.3 1.61958E7 2630000.0 1.48 1.378704E7 886156.931216899 0.52032907189334 1.3273 0.8303 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F14 mock treatment 1.238912E7 475000.0 0.27 1.471988E7 1160000.0 0.65 1.396012E7 1059236.9312169 0.621957296636364 0.889 0.9466 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F15 mock treatment 1.195704E7 42600.0 0.02 1.411064E7 548000.0 0.31 1.349376E7 592876.931216899 0.348122428996217 0.3928 0.8436 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F16 mock treatment 1.233104E7 417000.0 0.23 1.446796E7 905000.0 0.51 1.358364E7 682756.931216899 0.400897705399632 0.6607 0.9586 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F17 mock treatment 1.234492E7 431000.0 0.24 1.447176E7 909000.0 0.51 1.331756E7 416676.931216899 0.244662218690458 0.5762 0.9347 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F18 mock treatment 1.172164E7 -193000.0 -0.11 1.42876E7 725000.0 0.41 1.272592E7 -174963.068783101 -0.102733915391831 0.1137 0.2617 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F19 mock treatment 1.138372E7 -531000.0 -0.3 1.411112E7 548000.0 0.31 1.304304E7 142156.931216899 0.0834709761641415 0.0542 0.1241 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F20 mock treatment 1.157576E7 -339000.0 -0.19 1.405732E7 494000.0 0.28 1.254544E7 -355443.068783101 -0.208707234097752 -0.0697 -0.1757 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F21 mock treatment 1.153068E7 -384000.0 -0.22 1.34944E7 -68600.0 -0.04 1.267892E7 -221963.068783101 -0.130331133804831 -0.222 -0.8711 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F22 mock treatment 1.124756E7 -667000.0 -0.37 1.3352E7 -211000.0 -0.12 1.296872E7 67836.9312168993 0.0398321405800097 -0.2618 -0.6629 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F23 mock treatment 1.109104E7 -823000.0 -0.46 1.257752E7 -985000.0 -0.55 1.236268E7 -538203.068783101 -0.316019311484135 -0.7697 -0.9764 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base F24 mock treatment 1.002312E7 -1890000.0 -1.06 1.16362E7 -1930000.0 -1.08 1.139024E7 -1510643.0687831 -0.887011632197712 -1.7516 -0.9962 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G01 mock treatment 1.129984E7 -615000.0 -0.35 1.207508E7 -1490000.0 -0.84 1.269324E7 -207643.068783101 -0.121922789811764 -0.7533 -0.8241 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G02 mock treatment 1.161816E7 -296000.0 -0.17 1.326904E7 -294000.0 -0.17 1.328752E7 386636.931216899 0.227023485900532 -0.0605 -0.1854 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G03 mock treatment 1.130384E7 -611000.0 -0.34 1.308188E7 -481000.0 -0.27 1.299416E7 93276.9312168993 0.054769869014621 -0.3227 -0.7328 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G04 mock treatment 1.271772E7 803000.0 0.45 1.3825E7 262000.0 0.15 1.344836E7 547476.931216899 0.321464690358978 0.5312 0.9266 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G05 mock treatment 1.26124E7 698000.0 0.39 1.418084E7 618000.0 0.35 1.366696E7 766076.931216899 0.449821114722423 0.6868 0.9945 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G06 mock treatment 1.299476E7 1080000.0 0.61 1.53924E7 1830000.0 1.03 1.32932E7 392316.931216899 0.230358639104486 1.0779 0.8855 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G07 mock treatment 1.485468E7 2940000.0 1.65 1.648332E7 2920000.0 1.64 1.364976E7 748876.931216899 0.439721707132985 2.1565 0.9094 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G08 mock treatment 1.26586E7 744000.0 0.42 1.4294E7 731000.0 0.41 1.272348E7 -177403.068783101 -0.104166622049867 0.4188 0.7029 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G09 mock treatment 1.246272E7 548000.0 0.31 1.431188E7 749000.0 0.42 1.358184E7 680956.931216899 0.3998407906519 0.652 0.9916 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G10 mock treatment 1.256056E7 646000.0 0.36 1.51152E7 1550000.0 0.87 1.3978E7 1077116.9312169 0.632455983130501 1.0791 0.9482 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G11 mock treatment 1.230676E7 392000.0 0.22 1.486852E7 1310000.0 0.73 1.398552E7 1084636.9312169 0.636871538076581 0.9192 0.9219 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G12 mock treatment 1.355896E7 1640000.0 0.92 1.748012E7 3920000.0 2.2 1.388684E7 985956.931216899 0.578929122906477 2.1406 0.8703 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G13 mock treatment 1.284752E7 933000.0 0.52 1.456636E7 1000000.0 0.56 1.465512E7 1754236.9312169 1.03004382423286 1.2234 0.9511 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G14 mock treatment 1.260108E7 687000.0 0.39 1.459936E7 1040000.0 0.58 1.387128E7 970396.931216899 0.569792682087194 0.8885 0.9849 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G15 mock treatment 1.2137E7 223000.0 0.13 1.481476E7 1250000.0 0.7 1.334624E7 445356.931216899 0.261502393670987 0.63 0.8268 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G16 mock treatment 1.208248E7 168000.0 0.09 1.424824E7 685000.0 0.39 1.359388E7 692996.931216899 0.406910375964507 0.5121 0.9007 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G17 mock treatment 1.195864E7 44200.0 0.02 1.451016E7 947000.0 0.53 1.242628E7 -474603.068783101 -0.278674990397606 0.1613 0.2678 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G18 mock treatment 1.17032E7 -211000.0 -0.12 1.420124E7 638000.0 0.36 1.362172E7 720836.931216899 0.42325732406276 0.3833 0.6752 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G19 mock treatment 1.19338E7 19400.0 0.01 1.421548E7 652000.0 0.37 1.36308E7 729916.931216899 0.428588871790208 0.4658 0.8251 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G20 mock treatment 1.21196E7 205000.0 0.12 1.43186E7 756000.0 0.43 1.35138E7 612916.931216899 0.359889413187633 0.5199 0.9138 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G21 mock treatment 1.167596E7 -238000.0 -0.13 1.349428E7 -68700.0 -0.04 1.283888E7 -62003.0687831007 -0.0364066432230536 -0.1207 -0.8376 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G22 mock treatment 1.106284E7 -852000.0 -0.48 1.315716E7 -406000.0 -0.23 1.279036E7 -110523.068783101 -0.0648963674230277 -0.4455 -0.8343 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G23 mock treatment 1.12206E7 -694000.0 -0.39 1.292328E7 -640000.0 -0.36 1.232532E7 -575563.068783101 -0.337956164248171 -0.628 -0.9983 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base G24 mock treatment 1.02916E7 -1620000.0 -0.91 1.338032E7 -183000.0 -0.1 1.167756E7 -1223323.0687831 -0.718304551465302 -1.0003 -0.8586 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H01 mock treatment 1.133908E7 -575000.0 -0.32 1.263324E7 -930000.0 -0.52 1.320812E7 307236.931216899 0.180401802028357 -0.3846 -0.6 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H02 mock treatment 1.162704E7 -287000.0 -0.16 1.323356E7 -329000.0 -0.19 1.343468E7 533796.931216899 0.313432138276216 -0.0193 -0.0485 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H03 mock treatment 1.16248E7 -290000.0 -0.16 1.336132E7 -202000.0 -0.11 1.241212E7 -488763.068783101 -0.286989386413098 -0.3252 -0.932 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H04 mock treatment 1.254704E7 633000.0 0.36 1.396208E7 399000.0 0.22 1.30372E7 136316.931216899 0.0800418749826112 0.3811 0.8905 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H05 mock treatment 1.216404E7 250000.0 0.14 1.385632E7 293000.0 0.17 1.328436E7 383476.931216899 0.225168013343402 0.3063 0.9803 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H06 mock treatment 1.186084E7 -53600.0 -0.03 1.356736E7 4360.0 0.0 1.437508E7 1474196.9312169 0.865611376480165 0.4838 0.5586 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H07 mock treatment 1.223204E7 318000.0 0.18 1.429568E7 733000.0 0.41 1.334068E7 439796.931216899 0.258237701450215 0.4902 0.9458 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H08 mock treatment 1.230548E7 391000.0 0.22 1.403964E7 477000.0 0.27 1.363044E7 729556.931216899 0.428377488840662 0.529 0.9599 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H09 mock treatment 1.226008E7 346000.0 0.19 1.385072E7 288000.0 0.16 1.38522E7 951316.931216899 0.558589385761236 0.5281 0.8613 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H10 mock treatment 1.253076E7 616000.0 0.35 1.413544E7 572000.0 0.32 1.35746E7 673716.931216899 0.395589644666578 0.6143 0.9963 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H11 mock treatment 1.27388E7 824000.0 0.46 1.401732E7 454000.0 0.26 1.3914E7 1013116.9312169 0.594876792100032 0.7584 0.9528 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H12 mock treatment 1.486252E7 2950000.0 1.66 1.493628E7 1370000.0 0.77 1.353364E7 632756.931216899 0.371538962407078 1.6168 0.867 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H13 mock treatment 1.439384E7 2480000.0 1.39 1.44982E7 935000.0 0.53 1.454148E7 1640596.9312169 0.963317273159383 1.6642 0.9385 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H14 mock treatment 1.243004E7 516000.0 0.29 1.476996E7 1210000.0 0.68 1.32538E7 352916.931216899 0.207223949626354 0.6791 0.8853 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H15 mock treatment 1.222572E7 311000.0 0.17 1.466968E7 1110000.0 0.62 1.231076E7 -590123.068783101 -0.346505430207602 0.2606 0.355 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H16 mock treatment 1.122812E7 -686000.0 -0.39 1.396992E7 407000.0 0.23 1.352936E7 628476.931216899 0.369025854006915 0.1227 0.2114 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H17 mock treatment 1.085268E7 -1060000.0 -0.6 1.379556E7 233000.0 0.13 1.354264E7 641756.931216899 0.376823536145738 -0.0512 -0.0713 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H18 mock treatment 1.206568E7 151000.0 0.08 1.410072E7 538000.0 0.3 1.318636E7 285476.931216899 0.167624877077997 0.3206 0.8998 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H19 mock treatment 1.188756E7 -26900.0 -0.02 1.446136E7 898000.0 0.51 1.378556E7 884676.931216899 0.51946005310076 0.5832 0.8042 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H20 mock treatment 1.254008E7 626000.0 0.35 1.416944E7 606000.0 0.34 1.307788E7 176996.931216899 0.103928148281353 0.46 0.9184 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H21 mock treatment 1.240864E7 494000.0 0.28 1.397472E7 412000.0 0.23 1.255652E7 -344363.068783101 -0.202201336650603 0.1773 0.428 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H22 mock treatment 1.16044E7 -310000.0 -0.17 1.319012E7 -373000.0 -0.21 1.27122E7 -188683.068783101 -0.110789954468988 -0.2857 -0.9705 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H23 mock treatment 1.10082E7 -906000.0 -0.51 1.3169E7 -394000.0 -0.22 1.31038E7 202916.931216899 0.119147720648693 -0.3531 -0.6219 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base H24 mock treatment 9285520.0 -2630000.0 -1.48 1.268944E7 -874000.0 -0.49 1.142328E7 -1477603.0687831 -0.867611374828233 -1.6373 -0.9189 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I01 mock treatment 1.154976E7 -365000.0 -0.2 1.210696E7 -1460000.0 -0.82 1.222064E7 -680243.068783101 -0.399421628577381 -0.8221 -0.8797 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I02 mock treatment 1.151936E7 -395000.0 -0.22 1.324392E7 -319000.0 -0.18 1.264076E7 -260123.068783101 -0.152737726456748 -0.32 -0.9883 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I03 mock treatment 1.134016E7 -574000.0 -0.32 1.359996E7 37000.0 0.02 1.249012E7 -410763.068783101 -0.241189747344714 -0.3135 -0.7773 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I04 mock treatment 1.190348E7 -10900.0 -0.01 1.32676E7 -295000.0 -0.17 1.359064E7 689756.931216899 0.405007929418589 0.1343 0.3067 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I05 mock treatment 1.193156E7 17100.0 0.01 1.314724E7 -416000.0 -0.23 1.282376E7 -77123.0687831007 -0.0452847271040018 -0.1557 -0.6527 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I06 mock treatment 1.208448E7 170000.0 0.1 1.415588E7 593000.0 0.33 1.530988E7 2408996.9312169 1.41450243546895 1.0645 0.7309 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I07 mock treatment 1.226932E7 355000.0 0.2 1.431844E7 755000.0 0.43 1.388112E7 980236.931216899 0.575570482708129 0.6929 0.9328 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I08 mock treatment 1.287496E7 961000.0 0.54 1.457268E7 1010000.0 0.57 1.326584E7 364956.931216899 0.214293534938961 0.7634 0.9396 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I09 mock treatment 1.27056E7 791000.0 0.44 1.422756E7 665000.0 0.37 1.374124E7 840356.931216899 0.493436463312161 0.7574 0.9938 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I10 mock treatment 1.237028E7 456000.0 0.26 1.393168E7 369000.0 0.21 1.416752E7 1266636.9312169 0.743737362569476 0.697 0.8569 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I11 mock treatment 1.23586E7 444000.0 0.25 1.4178E7 615000.0 0.35 1.387236E7 971476.931216899 0.570426830935833 0.6732 0.9451 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I12 mock treatment 1.240388E7 489000.0 0.27 1.548368E7 1920000.0 1.08 1.365304E7 752156.931216899 0.441647640673296 1.0379 0.8651 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I13 mock treatment 1.212976E7 215000.0 0.12 1.393384E7 371000.0 0.21 1.428316E7 1382276.9312169 0.811638263362654 0.659 0.7782 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I14 mock treatment 1.218936E7 275000.0 0.15 1.410004E7 537000.0 0.3 1.315832E7 257436.931216899 0.151160494007773 0.351 0.9445 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I15 mock treatment 1.201232E7 97900.0 0.05 1.551788E7 1950000.0 1.1 1.331828E7 417396.931216899 0.245084984589551 0.8086 0.7164 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I16 mock treatment 1.2353E7 439000.0 0.25 1.39464E7 383000.0 0.22 1.339148E7 490596.931216899 0.288066184330649 0.4331 0.9931 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I17 mock treatment 1.130296E7 -611000.0 -0.34 1.400768E7 445000.0 0.25 1.308548E7 184596.931216899 0.108390677216221 0.0088 0.0201 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I18 mock treatment 1.134256E7 -572000.0 -0.32 1.366104E7 98000.0 0.06 1.301404E7 113156.931216899 0.0664429052284604 -0.1152 -0.3464 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I19 mock treatment 1.19196E7 5180.0 0.0 1.482796E7 1260000.0 0.71 1.222396E7 -676923.068783101 -0.397472208042675 0.1833 0.2248 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I20 mock treatment 1.131532E7 -599000.0 -0.34 1.334872E7 -214000.0 -0.12 1.158836E7 -1312523.0687831 -0.770680548964017 -0.7089 -0.8344 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I21 mock treatment 1.163404E7 -280000.0 -0.16 1.320544E7 -358000.0 -0.2 1.27472E7 -153683.068783101 -0.0902388343742 -0.2592 -0.9565 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I22 mock treatment 1.130868E7 -606000.0 -0.34 1.29892E7 -574000.0 -0.32 1.232368E7 -577203.068783101 -0.338919131018326 -0.5786 -0.9997 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I23 mock treatment 1.033604E7 -1580000.0 -0.89 1.29714E7 -592000.0 -0.33 1.32296E7 328716.931216899 0.193014318017958 -0.5927 -0.6132 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base I24 mock treatment 1.033764E7 -1580000.0 -0.89 1.236E7 -1200000.0 -0.68 1.097476E7 -1926123.0687831 -1.13097104296864 -1.5553 -0.9793 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J01 mock treatment 1.104104E7 -873000.0 -0.49 1.196456E7 -1600000.0 -0.9 1.240312E7 -497763.068783101 -0.292273960151757 -0.9715 -0.9116 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J02 mock treatment 1.086484E7 -1050000.0 -0.59 1.254276E7 -1020000.0 -0.57 1.224284E7 -658043.068783101 -0.386386346688687 -0.895 -0.9844 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J03 mock treatment 1.04166E7 -1500000.0 -0.84 1.305056E7 -512000.0 -0.29 1.28374E7 -63483.0687831007 -0.0372756620156332 -0.6738 -0.7569 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J04 mock treatment 1.18626E7 -51800.0 -0.03 1.348516E7 -77800.0 -0.04 1.319724E7 296356.931216899 0.174013339553177 0.0584 0.321 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J05 mock treatment 1.159536E7 -319000.0 -0.18 1.337408E7 -189000.0 -0.11 1.289944E7 -1443.06878310069 -8.47333710472609E-4 -0.1654 -0.7935 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J06 mock treatment 1.283836E7 924000.0 0.52 1.357448E7 11500.0 0.01 1.312768E7 226796.931216899 0.133169456301936 0.3802 0.7096 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J07 mock treatment 1.145668E7 -458000.0 -0.26 1.374088E7 178000.0 0.1 1.27802E7 -120683.068783101 -0.0708620639991146 -0.1315 -0.4618 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J08 mock treatment 1.241384E7 499000.0 0.28 1.391188E7 349000.0 0.2 1.32662E7 365316.931216899 0.214504917888507 0.3992 0.9879 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J09 mock treatment 1.248148E7 567000.0 0.32 1.473788E7 1170000.0 0.66 1.300652E7 105636.931216899 0.0620273502823803 0.6015 0.8166 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J10 mock treatment 1.213856E7 224000.0 0.13 1.400504E7 442000.0 0.25 1.390816E7 1007276.9312169 0.591447690918502 0.5578 0.8531 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J11 mock treatment 1.20084E7 94000.0 0.05 1.453972E7 977000.0 0.55 1.358924E7 688356.931216899 0.404185884614798 0.5813 0.8493 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J12 mock treatment 1.274004E7 826000.0 0.46 1.659616E7 3030000.0 1.71 1.444124E7 1540356.9312169 0.904458865207912 1.7757 0.8936 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J13 mock treatment 1.382004E7 1910000.0 1.07 1.447856E7 916000.0 0.52 1.321008E7 309196.931216899 0.181552664753665 1.0203 0.849 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J14 mock treatment 1.234808E7 434000.0 0.24 1.439444E7 831000.0 0.47 1.312544E7 224556.931216899 0.13185418461587 0.487 0.8954 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J15 mock treatment 1.228032E7 366000.0 0.21 1.369612E7 133000.0 0.07 1.329128E7 390396.931216899 0.229231263373572 0.2943 0.9287 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J16 mock treatment 1.192608E7 11700.0 0.01 1.356276E7 -245.0 0.0 1.497712E7 2076236.9312169 1.2191141291049 0.7076 0.5804 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J17 mock treatment 1.13264E7 -588000.0 -0.33 1.335684E7 -206000.0 -0.12 1.340344E7 502556.931216899 0.295088795654468 -0.0873 -0.1907 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J18 mock treatment 1.263308E7 719000.0 0.4 1.523696E7 1670000.0 0.94 1.332048E7 419596.931216899 0.246376769281223 0.9193 0.872 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J19 mock treatment 1.169212E7 -222000.0 -0.12 1.443392E7 871000.0 0.49 1.281928E7 -81603.0687831007 -0.0479152704761346 0.1833 0.3607 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J20 mock treatment 1.13426E7 -572000.0 -0.32 1.31054E7 -458000.0 -0.26 1.262456E7 -276323.068783101 -0.162249959186336 -0.4278 -0.9668 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J21 mock treatment 1.131932E7 -595000.0 -0.33 1.31528E7 -410000.0 -0.23 1.356872E7 667836.931216899 0.392137056490654 -0.0999 -0.1769 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J22 mock treatment 1.10708E7 -844000.0 -0.47 1.332384E7 -239000.0 -0.13 1.27794E7 -121483.068783101 -0.0713318038869954 -0.3925 -0.7885 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J23 mock treatment 1.097596E7 -938000.0 -0.53 1.277712E7 -786000.0 -0.44 1.202752E7 -873363.068783101 -0.51281683751182 -0.8558 -0.9972 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base J24 mock treatment 1.022988E7 -1680000.0 -0.95 1.117092E7 -2390000.0 -1.35 1.168696E7 -1213923.0687831 -0.712785107782702 -1.7352 -0.9675 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K01 mock treatment 1.03976E7 -1520000.0 -0.85 1.17386E7 -1820000.0 -1.03 1.188032E7 -1020563.0687831 -0.599248976881898 -1.4308 -0.9781 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K02 mock treatment 1.252292E7 609000.0 0.34 1.420396E7 641000.0 0.36 1.201448E7 -886403.068783101 -0.520473597684278 0.1051 0.1461 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K03 mock treatment 1.141E7 -504000.0 -0.28 1.341196E7 -151000.0 -0.09 1.24672E7 -433683.068783101 -0.2546477951325 -0.3597 -0.9215 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K04 mock treatment 1.184688E7 -67500.0 -0.04 1.272556E7 -837000.0 -0.47 1.223864E7 -662243.068783101 -0.388852481100062 -0.5186 -0.847 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K05 mock treatment 1.132352E7 -591000.0 -0.33 1.240128E7 -1160000.0 -0.65 1.248616E7 -414723.068783101 -0.243514959789724 -0.7098 -0.9185 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K06 mock treatment 1.211456E7 200000.0 0.11 1.400384E7 441000.0 0.25 1.218556E7 -715323.068783101 -0.420019722660957 -0.0343 -0.0686 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K07 mock treatment 1.19548E7 40400.0 0.02 1.355416E7 -8840.0 0.0 1.29992E7 98316.9312168993 0.0577292303082704 0.0436 0.6999 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K08 mock treatment 1.232516E7 411000.0 0.23 1.36434E7 80400.0 0.05 1.28628E7 -38083.0687831007 -0.0223614205754159 0.1464 0.62 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K09 mock treatment 1.18206E7 -93800.0 -0.05 1.372548E7 162000.0 0.09 1.326512E7 364236.931216899 0.213870769039868 0.1459 0.6116 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K10 mock treatment 1.161316E7 -301000.0 -0.17 1.395972E7 397000.0 0.22 1.37958E7 894916.931216899 0.525472723665635 0.3346 0.5619 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K11 mock treatment 1.16572E7 -257000.0 -0.14 1.375012E7 187000.0 0.11 1.294836E7 47476.9312168993 0.0278772604334419 -0.0065 -0.036 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K12 mock treatment 1.196992E7 55500.0 0.03 1.3638E7 75000.0 0.04 1.46152E7 1714316.9312169 1.0066038038276 0.6235 0.6186 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K13 mock treatment 1.29302E7 1020000.0 0.57 1.320216E7 -361000.0 -0.2 1.281596E7 -84923.0687831007 -0.0498646910108402 0.1833 0.3017 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K14 mock treatment 1.247712E7 563000.0 0.32 1.362604E7 63000.0 0.04 1.426708E7 1366196.9312169 0.802196491616249 0.6661 0.7719 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K15 mock treatment 1.179932E7 -115000.0 -0.06 1.33956E7 -167000.0 -0.09 1.283148E7 -69403.0687831007 -0.0407517371859515 -0.1153 -0.95 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K16 mock treatment 1.165424E7 -260000.0 -0.15 1.335592E7 -207000.0 -0.12 1.233968E7 -561203.068783101 -0.329524333260709 -0.3419 -0.9025 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K17 mock treatment 1.122848E7 -686000.0 -0.39 1.346376E7 -99200.0 -0.06 1.267128E7 -229603.068783101 -0.134817149734093 -0.3325 -0.8071 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K18 mock treatment 1.310652E7 1190000.0 0.67 1.502572E7 1460000.0 0.82 1.428028E7 1379396.9312169 0.809947199766283 1.3296 0.9959 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K19 mock treatment 1.13024E7 -612000.0 -0.34 1.327816E7 -285000.0 -0.16 1.250396E7 -396923.068783101 -0.233063247284375 -0.4256 -0.956 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K20 mock treatment 1.092376E7 -991000.0 -0.56 1.25884E7 -975000.0 -0.55 1.20456E7 -855283.068783101 -0.502200716045713 -0.9279 -0.999 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K21 mock treatment 1.122604E7 -688000.0 -0.39 1.262264E7 -940000.0 -0.53 1.201252E7 -888363.068783101 -0.521624460409586 -0.83 -0.9908 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K22 mock treatment 1.077968E7 -1130000.0 -0.64 1.353904E7 -24000.0 -0.01 1.14888E7 -1412083.0687831 -0.82913967801079 -0.8545 -0.817 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K23 mock treatment 1.129824E7 -616000.0 -0.35 1.258728E7 -976000.0 -0.55 1.21892E7 -711683.068783101 -0.417882406171099 -0.7582 -0.982 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base K24 mock treatment 1.118112E7 -733000.0 -0.41 1.249812E7 -1060000.0 -0.6 1.082636E7 -2074523.0687831 -1.21810779217054 -1.2872 -0.9073 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L01 mock treatment 1.160608E7 -308000.0 -0.17 1.292128E7 -642000.0 -0.36 1.206728E7 -833603.068783101 -0.489470765084142 -0.5911 -0.9346 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L02 mock treatment 1.148096E7 -433000.0 -0.24 1.318316E7 -380000.0 -0.21 1.3157E7 256116.931216899 0.15038542319277 -0.1772 -0.496 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L03 mock treatment 1.216724E7 253000.0 0.14 1.323712E7 -326000.0 -0.18 1.295888E7 57996.9312168993 0.0340543399590752 -0.0043 -0.0182 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L04 mock treatment 1.254856E7 634000.0 0.36 1.315452E7 -408000.0 -0.23 1.301184E7 110956.931216899 0.065151120536788 0.1105 0.2576 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L05 mock treatment 1.268524E7 771000.0 0.43 1.34262E7 -137000.0 -0.08 1.262644E7 -274443.068783101 -0.161146070449816 0.1125 0.2401 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L06 mock treatment 1.287712E7 963000.0 0.54 1.427792E7 715000.0 0.4 1.35092E7 608316.931216899 0.357188408832318 0.7508 0.9842 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L07 mock treatment 1.239592E7 482000.0 0.27 1.387612E7 313000.0 0.18 1.368524E7 784356.931216899 0.460554671160501 0.5238 0.9313 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L08 mock treatment 1.228996E7 376000.0 0.21 1.401288E7 450000.0 0.25 1.338848E7 487596.931216899 0.286304659751096 0.4333 0.9925 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L09 mock treatment 1.306688E7 1150000.0 0.65 1.392908E7 366000.0 0.21 1.29314E7 30516.9312168993 0.0179187748103677 0.503 0.7403 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L10 mock treatment 1.35476E7 1630000.0 0.92 1.444904E7 886000.0 0.5 1.35472E7 646316.931216899 0.379501053506658 1.0367 0.9331 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L11 mock treatment 1.293508E7 1020000.0 0.57 1.400624E7 443000.0 0.25 1.306344E7 162556.931216899 0.0954493433051034 0.5301 0.8382 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L12 mock treatment 1.242932E7 515000.0 0.29 1.55064E7 1940000.0 1.09 1.35714E7 670516.931216899 0.393710685115054 1.0259 0.8563 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L13 mock treatment 1.383492E7 1920000.0 1.08 1.428576E7 723000.0 0.41 1.328996E7 389076.931216899 0.228456192558568 0.9896 0.842 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L14 mock treatment 1.27482E7 834000.0 0.47 1.382772E7 265000.0 0.15 1.33234E7 422516.931216899 0.248091319871988 0.4997 0.9076 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L15 mock treatment 1.221604E7 302000.0 0.17 1.397268E7 410000.0 0.23 1.315364E7 252756.931216899 0.14841251566367 0.3166 0.9823 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L16 mock treatment 1.171784E7 -197000.0 -0.11 1.370132E7 138000.0 0.08 1.35024E7 601516.931216899 0.35319561978533 0.1851 0.4895 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L17 mock treatment 1.286204E7 948000.0 0.53 1.400744E7 444000.0 0.25 1.33774E7 476516.931216899 0.279798762303946 0.6133 0.9416 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L18 mock treatment 1.25848E7 670000.0 0.38 1.350848E7 -54500.0 -0.03 1.294436E7 43476.9312168993 0.0255285609940376 0.2144 0.5663 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L19 mock treatment 1.268252E7 768000.0 0.43 1.374404E7 181000.0 0.1 1.279324E7 -107643.068783101 -0.0632053038266566 0.2714 0.6062 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L20 mock treatment 1.223644E7 322000.0 0.18 1.309364E7 -469000.0 -0.26 1.271952E7 -181363.068783101 -0.106491834494878 -0.1096 -0.3248 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L21 mock treatment 1.150992E7 -404000.0 -0.23 1.251604E7 -1050000.0 -0.59 1.223456E7 -666323.068783101 -0.391248154528254 -0.6973 -0.9385 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L22 mock treatment 1.138844E7 -526000.0 -0.3 1.254304E7 -1020000.0 -0.57 1.184912E7 -1051763.0687831 -0.617568832509252 -0.8586 -0.961 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L23 mock treatment 1.105668E7 -858000.0 -0.48 1.215024E7 -1410000.0 -0.8 1.208148E7 -819403.068783101 -0.481132882074256 -1.0151 -0.9696 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base L24 mock treatment 1.035296E7 -1560000.0 -0.88 1.23728E7 -1190000.0 -0.67 1.082544E7 -2075443.0687831 -1.2186479930416 -1.5968 -0.9712 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M01 mock treatment 1.068092E7 -1230000.0 -0.69 1.165476E7 -1910000.0 -1.07 1.20452E7 -855683.068783101 -0.502435585989653 -1.3103 -0.954 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M02 mock treatment 1.171812E7 -196000.0 -0.11 1.287164E7 -691000.0 -0.39 1.168528E7 -1215603.0687831 -0.713771561547251 -0.7004 -0.8538 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M03 mock treatment 1.176652E7 -148000.0 -0.08 1.275312E7 -810000.0 -0.46 1.206624E7 -834643.068783101 -0.490081426938387 -0.5941 -0.8809 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M04 mock treatment 1.22688E7 354000.0 0.2 1.303788E7 -525000.0 -0.3 1.216008E7 -740803.068783101 -0.434980938089962 -0.3069 -0.5457 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M05 mock treatment 1.159788E7 -317000.0 -0.18 1.398308E7 420000.0 0.24 1.270936E7 -191523.068783101 -0.112457531070965 -0.0311 -0.0981 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M06 mock treatment 1.277712E7 863000.0 0.48 1.362464E7 61600.0 0.03 1.377096E7 870076.931216899 0.510887300146935 0.5948 0.8436 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M07 mock treatment 1.23808E7 466000.0 0.26 1.289348E7 -670000.0 -0.38 1.26252E7 -275683.068783101 -0.161874167276031 -0.1598 -0.3284 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M08 mock treatment 1.24742E7 560000.0 0.31 1.376164E7 199000.0 0.11 1.27074E7 -193483.068783101 -0.113608393796273 0.1805 0.512 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M09 mock treatment 1.219676E7 282000.0 0.16 1.373212E7 169000.0 0.1 1.335412E7 453236.931216899 0.266129331566613 0.3002 0.9262 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M10 mock treatment 1.213004E7 216000.0 0.12 1.401836E7 455000.0 0.26 1.327496E7 374076.931216899 0.219648569660802 0.3447 0.9612 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M11 mock treatment 1.306008E7 1150000.0 0.64 1.406516E7 502000.0 0.28 1.311368E7 212796.931216899 0.124949008264021 0.6069 0.8501 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M12 mock treatment 1.238088E7 466000.0 0.26 1.478836E7 1230000.0 0.69 1.281964E7 -81243.0687831007 -0.0477038875265882 0.522 0.7059 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M13 mock treatment 1.342868E7 1510000.0 0.85 1.383444E7 271000.0 0.15 1.36432E7 742316.931216899 0.435869840052361 0.8309 0.8585 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M14 mock treatment 1.294212E7 1030000.0 0.58 1.425988E7 697000.0 0.39 1.289804E7 -2843.06878310069 -0.00166937851426411 0.5588 0.8006 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M15 mock treatment 1.262116E7 707000.0 0.4 1.383612E7 273000.0 0.15 1.298804E7 87156.9312168993 0.0511763588723325 0.3475 0.8105 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M16 mock treatment 1.201696E7 103000.0 0.06 1.40988E7 536000.0 0.3 1.291696E7 16076.9312168993 0.00943996983411819 0.2128 0.6928 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M17 mock treatment 1.281344E7 899000.0 0.5 1.376964E7 207000.0 0.12 1.261036E7 -290523.068783101 -0.170587842196221 0.2602 0.477 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M18 mock treatment 1.198268E7 68300.0 0.04 1.295408E7 -609000.0 -0.34 1.167672E7 -1224163.0687831 -0.718797778347577 -0.5908 -0.741 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M19 mock treatment 1.209836E7 184000.0 0.1 1.370388E7 141000.0 0.08 1.23216E7 -579283.068783101 -0.340140454726817 -0.0909 -0.2497 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M20 mock treatment 1.16816E7 -233000.0 -0.13 1.306688E7 -496000.0 -0.28 1.282744E7 -73443.0687831007 -0.0431239236197499 -0.2616 -0.8403 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M21 mock treatment 1.097744E7 -937000.0 -0.53 1.323832E7 -325000.0 -0.18 1.178224E7 -1118643.0687831 -0.656839087136091 -0.7886 -0.9156 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M22 mock treatment 1.112208E7 -792000.0 -0.45 1.241496E7 -1150000.0 -0.65 1.168056E7 -1220323.0687831 -0.716543026885749 -1.0438 -0.9823 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M23 mock treatment 1.112776E7 -787000.0 -0.44 1.202856E7 -1530000.0 -0.86 1.145616E7 -1444723.0687831 -0.848305065436329 -1.2436 -0.9649 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base M24 mock treatment 1.052704E7 -1390000.0 -0.78 1.14598E7 -2100000.0 -1.18 1.05178E7 -2383083.0687831 -1.39928646692618 -1.9413 -0.9747 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N01 mock treatment 1.329716E7 1380000.0 0.78 1.300968E7 -553000.0 -0.31 1.282768E7 -73203.0687831007 -0.0429830016533856 0.2438 0.2909 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N02 mock treatment 1.56722E7 3760000.0 2.11 1.435232E7 789000.0 0.44 1.37038E7 802916.931216899 0.471452636559337 1.7473 0.7914 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N03 mock treatment 1.555696E7 3640000.0 2.05 1.513084E7 1570000.0 0.88 1.310172E7 200836.931216899 0.117926396940202 1.7589 0.7883 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N04 mock treatment 1.789844E7 5980000.0 3.36 1.74714E7 3910000.0 2.2 1.336496E7 464076.931216899 0.272494307047399 3.3681 0.8365 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N05 mock treatment 1.655292E7 4640000.0 2.61 1.544732E7 1880000.0 1.06 1.244632E7 -454563.068783101 -0.266908006206191 1.9625 0.6945 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N06 mock treatment 1.358612E7 1670000.0 0.94 1.4733E7 1170000.0 0.66 1.346152E7 560636.931216899 0.329191911514619 1.1124 0.9323 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N07 mock treatment 1.413256E7 2220000.0 1.25 1.448084E7 918000.0 0.52 1.384668E7 945796.931216899 0.555348180534858 1.3382 0.9175 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N08 mock treatment 1.096044E7 -954000.0 -0.54 1.531172E7 1750000.0 0.98 1.34746E7 573716.931216899 0.336872158681471 0.4535 0.3875 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N09 mock treatment 1.263652E7 722000.0 0.41 1.450916E7 946000.0 0.53 1.430016E7 1399276.9312169 0.821620235980122 1.016 0.9587 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N10 mock treatment 1.437384E7 2460000.0 1.38 1.512268E7 1560000.0 0.88 1.494036E7 2039476.9312169 1.19752958125678 1.9958 0.9841 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N11 mock treatment 1.31266E7 1210000.0 0.68 1.842632E7 4860000.0 2.74 1.408556E7 1184676.9312169 0.695612511056082 2.3753 0.8175 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N12 mock treatment 1.816076E7 6250000.0 3.51 1.723936E7 3680000.0 2.07 1.333624E7 435356.931216899 0.255630645072476 3.368 0.8252 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N13 mock treatment 1.88118E7 6900000.0 3.87 1.809432E7 4530000.0 2.55 1.452436E7 1623476.9312169 0.953264839558733 4.2598 0.8996 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N14 mock treatment 1.571048E7 3800000.0 2.13 1.649712E7 2930000.0 1.65 1.44156E7 1514716.9312169 0.88940370180133 2.6981 0.9501 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N15 mock treatment 1.299076E7 1080000.0 0.6 1.487212E7 1310000.0 0.74 1.5541E7 2640116.9312169 1.55021028907773 1.6695 0.9174 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N16 mock treatment 1.29392E7 1020000.0 0.58 1.46646E7 1100000.0 0.62 1.37784E7 877516.931216899 0.515255881104226 0.9878 0.9972 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N17 mock treatment 1.2437E7 523000.0 0.29 1.404208E7 479000.0 0.27 1.312904E7 228156.931216899 0.133968014111334 0.4025 0.9572 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N18 mock treatment 1.199836E7 83900.0 0.05 1.38392E7 276000.0 0.16 1.326088E7 359996.931216899 0.211381147634099 0.239 0.8966 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N19 mock treatment 1.225804E7 344000.0 0.19 1.3539E7 -24000.0 -0.01 1.306784E7 166956.931216899 0.0980329126884481 0.1602 0.7387 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N20 mock treatment 1.208296E7 169000.0 0.09 1.402472E7 462000.0 0.26 1.356788E7 666996.931216899 0.391643829608379 0.4308 0.8985 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N21 mock treatment 1.2049E7 135000.0 0.08 1.43346E7 772000.0 0.43 1.293108E7 30196.9312168993 0.0177308788552153 0.3046 0.6905 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N22 mock treatment 1.155852E7 -356000.0 -0.2 1.283348E7 -730000.0 -0.41 1.254568E7 -355203.068783101 -0.208566312131388 -0.4729 -0.9419 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N23 mock treatment 1.252996E7 616000.0 0.35 1.326648E7 -297000.0 -0.17 1.235936E7 -541523.068783101 -0.31796873201884 -0.0803 -0.1612 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base N24 mock treatment 1.380284E7 1890000.0 1.06 1.225964E7 -1300000.0 -0.73 1.098152E7 -1919363.0687831 -1.12700174091604 -0.4619 -0.2697 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O01 mock treatment 9577480.0 -2340000.0 -1.31 1.182632E7 -1740000.0 -0.98 1.536636E7 2465476.9312169 1.44766607155334 -0.4864 -0.2226 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O02 mock treatment 1.287664E7 962000.0 0.54 1.400944E7 446000.0 0.25 1.317404E7 273156.931216899 0.160390882804632 0.5497 0.8906 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O03 mock treatment 1.21332E7 219000.0 0.12 1.39626E7 400000.0 0.22 1.25178E7 -383083.068783101 -0.224936747224036 0.0709 0.208 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O04 mock treatment 1.1672E7 -242000.0 -0.14 1.285248E7 -711000.0 -0.4 1.305608E7 155196.931216899 0.0911277363365995 -0.2569 -0.5944 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O05 mock treatment 1.207268E7 158000.0 0.09 1.27476E7 -815000.0 -0.46 1.235012E7 -550763.068783101 -0.323394227723864 -0.4004 -0.7043 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O06 mock treatment 1.245792E7 544000.0 0.31 1.382292E7 260000.0 0.15 1.242124E7 -479643.068783101 -0.281634351691256 0.0981 0.2228 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O07 mock treatment 1.466552E7 2750000.0 1.55 1.63576E7 2790000.0 1.57 1.355656E7 655676.931216899 0.384997010194864 2.0227 0.9036 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O08 mock treatment 1.136612E7 -548000.0 -0.31 1.310864E7 -454000.0 -0.26 1.28998E7 -1083.06878310069 -6.35950760926222E-4 -0.3258 -0.8139 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O09 mock treatment 1.296004E7 1050000.0 0.59 1.363116E7 68200.0 0.04 1.32016E7 300716.931216899 0.176573421942128 0.4632 0.7538 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O10 mock treatment 1.268928E7 775000.0 0.44 1.396416E7 401000.0 0.23 1.392672E7 1025836.9312169 0.602345656317338 0.7294 0.9391 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O11 mock treatment 1.236168E7 447000.0 0.25 1.352512E7 -37900.0 -0.02 1.38284E7 927516.931216899 0.54461462409678 0.4472 0.7451 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O12 mock treatment 1.21282E7 214000.0 0.12 1.492264E7 1360000.0 0.77 1.329756E7 396676.931216899 0.232918721493437 0.6457 0.7981 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O13 mock treatment 1.213912E7 225000.0 0.13 1.360004E7 37000.0 0.02 1.373664E7 835756.931216899 0.490735458956846 0.3682 0.7261 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O14 mock treatment 1.303164E7 1120000.0 0.63 1.463112E7 1070000.0 0.6 1.460812E7 1707236.9312169 1.00244660581986 1.2882 0.971 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O15 mock treatment 1.221616E7 302000.0 0.17 1.348992E7 -73100.0 -0.04 1.281936E7 -81523.0687831007 -0.0478682964873465 0.0465 0.2569 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O16 mock treatment 1.643788E7 4520000.0 2.54 1.477648E7 1210000.0 0.68 1.337596E7 475076.931216899 0.278953230505761 2.0223 0.7644 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O17 mock treatment 1.172928E7 -185000.0 -0.1 1.339524E7 -168000.0 -0.09 1.274952E7 -151363.068783101 -0.0888765886993455 -0.1659 -0.9979 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O18 mock treatment 1.2677E7 763000.0 0.43 1.363764E7 74600.0 0.04 1.318104E7 280156.931216899 0.16450110682359 0.3665 0.7955 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O19 mock treatment 1.12242E7 -690000.0 -0.39 1.300076E7 -562000.0 -0.32 1.304496E7 144076.931216899 0.0845983518950555 -0.3577 -0.7048 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O20 mock treatment 1.43192E7 2400000.0 1.35 1.283048E7 -733000.0 -0.41 1.210508E7 -795803.068783101 -0.467275555381771 0.272 0.1828 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O21 mock treatment 1.121336E7 -701000.0 -0.39 1.268292E7 -880000.0 -0.5 1.106024E7 -1840643.0687831 -1.08077933594857 -1.1374 -0.9081 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O22 mock treatment 1.191276E7 -1660.0 0.0 1.242708E7 -1140000.0 -0.64 1.133232E7 -1568563.0687831 -0.921020800080286 -0.9015 -0.804 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O23 mock treatment 1.065152E7 -1260000.0 -0.71 1.150436E7 -2060000.0 -1.16 1.17262E7 -1174683.0687831 -0.689744366282146 -1.4768 -0.9692 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base O24 mock treatment 1.020416E7 -1710000.0 -0.96 1.095024E7 -2610000.0 -1.47 9589680.0 -3311203.0687831 -1.94425519785116 -2.5263 -0.9641 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P01 mock treatment 9639480.0 -2270000.0 -1.28 1.03676E7 -3200000.0 -1.8 1.043184E7 -2469043.0687831 -1.44976001787898 -2.6132 -0.9898 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P02 mock treatment 1.09212E7 -993000.0 -0.56 1.199968E7 -1560000.0 -0.88 1.132312E7 -1577763.0687831 -0.926422808790916 -1.365 -0.9791 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P03 mock treatment 1.04336E7 -1480000.0 -0.83 1.204004E7 -1520000.0 -0.86 1.27746E7 -126283.068783101 -0.0741502432142806 -1.018 -0.8506 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P04 mock treatment 1.079132E7 -1120000.0 -0.63 1.282564E7 -737000.0 -0.42 1.20112E7 -889683.068783101 -0.52239953122459 -0.9055 -0.9861 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P05 mock treatment 1.259556E7 681000.0 0.38 1.373848E7 175000.0 0.1 1.207396E7 -826923.068783101 -0.485548437020336 -0.0024 -0.0039 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P06 mock treatment 1.183348E7 -80900.0 -0.05 1.272492E7 -838000.0 -0.47 1.218732E7 -713563.068783101 -0.418986294907619 -0.5405 -0.8545 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P07 mock treatment 1.205672E7 142000.0 0.08 1.298332E7 -580000.0 -0.33 1.241116E7 -489723.068783101 -0.287553074278555 -0.3083 -0.6971 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P08 mock treatment 1.19868E7 72400.0 0.04 1.306288E7 -500000.0 -0.28 1.360004E7 699156.931216899 0.410527373101189 0.098 0.1961 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P09 mock treatment 1.212384E7 209000.0 0.12 1.327616E7 -287000.0 -0.16 1.225072E7 -650163.068783101 -0.381759408793061 -0.2457 -0.5703 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P10 mock treatment 1.160788E7 -307000.0 -0.17 1.222308E7 -1340000.0 -0.75 1.252788E7 -373003.068783101 -0.219018024636737 -0.6613 -0.8225 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P11 mock treatment 1.224564E7 331000.0 0.19 1.339144E7 -172000.0 -0.1 1.301852E7 117636.931216899 0.0690734486005932 0.0915 0.4147 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P12 mock treatment 1.132348E7 -591000.0 -0.33 1.275932E7 -804000.0 -0.45 1.204104E7 -859843.068783101 -0.504878233406634 -0.7443 -0.9861 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P13 mock treatment 1.277808E7 864000.0 0.49 1.370524E7 142000.0 0.08 1.304076E7 139876.931216899 0.082132217483681 0.3737 0.7497 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P14 mock treatment 1.198672E7 72300.0 0.04 1.304404E7 -519000.0 -0.29 1.209564E7 -805243.068783101 -0.472818486058765 -0.4182 -0.7504 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P15 mock treatment 1.19658E7 51400.0 0.03 1.293444E7 -629000.0 -0.35 1.230476E7 -596123.068783101 -0.350028479366709 -0.3897 -0.7817 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P16 mock treatment 1.19796E7 65200.0 0.04 1.29068E7 -656000.0 -0.37 1.237472E7 -526163.068783101 -0.308949726171528 -0.3705 -0.7672 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P17 mock treatment 1.182168E7 -92700.0 -0.05 1.268404E7 -879000.0 -0.49 1.193032E7 -970563.068783101 -0.569890233889344 -0.6448 -0.8523 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P18 mock treatment 1.12772E7 -637000.0 -0.36 1.155736E7 -2010000.0 -1.13 1.257568E7 -325203.068783101 -0.190951066335856 -0.9687 -0.8075 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P19 mock treatment 1.138076E7 -534000.0 -0.3 1.265428E7 -909000.0 -0.51 1.156184E7 -1339043.0687831 -0.786252426247268 -0.9223 -0.9366 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P20 mock treatment 1.10472E7 -867000.0 -0.49 1.172668E7 -1840000.0 -1.03 1.184176E7 -1059123.0687831 -0.621890439477756 -1.2371 -0.9509 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P21 mock treatment 1.11986E7 -716000.0 -0.4 1.231948E7 -1240000.0 -0.7 1.114728E7 -1753603.0687831 -1.02967163614713 -1.2308 -0.9407 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P22 mock treatment 1.129356E7 -621000.0 -0.35 1.164968E7 -1910000.0 -1.08 1.157292E7 -1327963.0687831 -0.779746528800118 -1.2733 -0.9263 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P23 mock treatment 1.043408E7 -1480000.0 -0.83 1.092248E7 -2640000.0 -1.49 1.04504E7 -2450483.0687831 -1.43886205248014 -2.1689 -0.9728 1054.0011 CellTiterGlo(1054.0011) KRasSyntheticLethal 1054.0011.Base P24 mock treatment 8079120.0 -3840000.0 -2.15 8086080.0 -5480000.0 -3.08 8859720.0 -4041163.0687831 -2.37286935854805 -4.3937 -0.988