ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_C BSUB_VALUE_C Z_SCORE_C COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A01 compound treatment 6399240.0 -1478329.65517241 -1.63460439536885 -1.6346 -1.0 3085008 TimTec1_004225 CC(=C)CS(=O)(=O)c1ccccc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A02 compound treatment 6407960.0 -1469609.65517241 -1.62496260114674 -1.625 -1.0 1397478 TimTec1_004226 COc1ccc(NC(=O)C2C(=C2c3ccccc3)c4ccccc4)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A03 compound treatment 6026080.0 -1851489.65517241 -2.04721126829579 -2.0472 -1.0 1295145 TimTec1_004227 CCOC(=O)C1(C(CC(=O)CC1c2ccccc2)c3ccccc3)C(=O)OCC 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A04 compound treatment 6483000.0 -1394569.65517241 -1.54199009673996 -1.542 -1.0 1717498 TimTec1_004228 CC(C)(C)C(=O)NCCc1c[nH]c2ccccc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A05 compound treatment 6541520.0 -1336049.65517241 -1.47728392725854 -1.4773 -1.0 3212224 TimTec1_004229 CC(C)(COC(=O)c1ccccc1)NC2=NS(=O)(=O)c3ccccc23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A06 compound treatment 7222560.0 -655009.65517241 -0.724250952828915 -0.7243 -1.0 1324852 TimTec1_004230 CC1CC(O)(Cc2ccc(C)cc2)C(C)CN1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A07 compound treatment 6804320.0 -1073249.65517241 -1.18670324817933 -1.1867 -1.0 1528736 TimTec1_004231 COc1cccc(CC(C)C(=O)N)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A08 compound treatment 6791640.0 -1085929.65517241 -1.20072365537387 -1.2007 -1.0 3212225 TimTec1_004232 COc1c(ccc2ccccc12)C(=O)NCCOc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A09 compound treatment 6420840.0 -1456729.65517241 -1.61072105188289 -1.6107 -1.0 3212226 TimTec1_004233 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4CC(=O)CCC4(C)C3CCC21C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A10 compound treatment 4017400.0 -3860169.65517241 -4.26822952724872 -4.2682 -1.0 1391256 TimTec1_004234 O=C(COc1cccc(OCC(=O)Nc2ccccn2)c1)Nc3ccccn3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A11 compound treatment 6476160.0 -1401409.65517241 -1.54955315551051 -1.5496 -1.0 3085079 TimTec1_004235 CN(CP(=O)(O)CN1CCCC1=O)C(=O)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A12 compound treatment 6530880.0 -1346689.65517241 -1.48904868534607 -1.489 -1.0 1155490 TimTec1_004236 OC(=O)CN(CC(=O)O)c1ccc(Cl)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A13 compound treatment 6784320.0 -1093249.65517241 -1.20881745511078 -1.2088 -1.0 3085081 TimTec1_004237 O/N=C/C(=O)Nc1ccccc1C(=O)O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A14 compound treatment 6235360.0 -1642209.65517241 -1.81580820696513 -1.8158 -1.0 1152383 TimTec1_004238 COc1ccc(NC(=O)C2C3C2C4CCC3C4)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A15 compound treatment 5846320.0 -2031249.65517241 -2.24597376019563 -2.246 -1.0 1199333 TimTec1_004239 O=C(NCc1ccccc1)C2CC2(c3ccccc3)c4ccccc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A16 compound treatment 544480.0 -7333089.65517241 -8.10827310406673 -8.1083 -1.0 3212227 TimTec1_004240 Cc1ccc(cc1)C(=O)CC(C(C#N)C#N)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A17 compound treatment 7201000.0 -676569.65517241 -0.748090067901015 -0.7481 -1.0 3085083 TimTec1_004241 O=c1[nH][nH]c(=O)c2c(/N=C/c3cccc4ccccc34)cccc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A18 compound treatment 6209280.0 -1668289.65517241 -1.84464513280374 -1.8446 -1.0 3212228 TimTec1_004242 COc1ccc(OC)c(NC(=O)C2C3CC/C=C/CC\C=C/CCC23)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A19 compound treatment 5460280.0 -2417289.65517241 -2.67282218238642 -2.6728 -1.0 3085086 TimTec1_004243 Brc1ccccc1NC(=O)CSc2nc3ccccc3[nH]2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A20 compound treatment 5367840.0 -2509729.65517241 -2.77503404682357 -2.775 -1.0 3212229 TimTec1_004244 COc1ccc(cc1)N2C(=O)C(=CC2(OC)c3ccccc3)O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A21 compound treatment 6078160.0 -1799409.65517241 -1.9896258734463 -1.9896 -1.0 3085088 TimTec1_004245 CN(C)/N=C/c1ccc(OC(=O)c2ccc(Br)cc2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A22 compound treatment 6580600.0 -1296969.65517241 -1.43407276691449 -1.4341 -1.0 3212230 TimTec1_004246 O=C(CSc1ccccn1)N2CCCc3ccccc23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A23 mock treatment 6992040.0 -885529.65517241 -0.979139301920771 -0.9791 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 A24 mock treatment 6237640.0 -1639929.65517241 -1.81328718737494 -1.8133 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B01 compound treatment 7100880.0 -776689.65517241 -0.858793787799838 -0.8588 -1.0 1674437 TimTec1_004247 CCN1N=C(C)C=C(C)n2c1nc3ccccc23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B02 compound treatment 6630440.0 -1247129.65517241 -1.37896416324133 -1.379 -1.0 1696382 TimTec1_004248 Cc1ccc(NC(=O)C2C3CCCCC=CC23)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B03 compound treatment 6896280.0 -981289.65517241 -1.08502212470854 -1.085 -1.0 3212231 TimTec1_004249 CCC1SC(=NC1=O)Nc2ccc(C)cc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B04 compound treatment 7696760.0 -180809.65517241 -0.199923106484311 -0.1999 -1.0 1427335 TimTec1_004250 C=CCN(CC=C)S(=O)(=O)c1ncn[nH]1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B05 compound treatment 7651520.0 -226049.65517241 -0.249945442563244 -0.2499 -1.0 3085092 TimTec1_004251 Nc1cc(ccc1OCc2ccccc2)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B06 compound treatment 6746200.0 -1131369.65517241 -1.25096713352212 -1.251 -1.0 3212232 TimTec1_004252 CN(C)c1c(C(=C(C#N)C#N)C#N)c2ccccc2n1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B07 compound treatment 6884000.0 -993569.65517241 -1.09860024776445 -1.0986 -1.0 3085094 TimTec1_004253 OC(=O)c1ccc(CSc2ccccn2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B08 compound treatment 7731680.0 -145889.65517241 -0.161311701182005 -0.1613 -1.0 1347619 TimTec1_004254 CCC1NC(=S)NC(=C1C(=O)c2ccccc2)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B09 compound treatment 8448240.0 570670.34482759 0.630996104757871 0.631 1.0 3085159 TimTec1_004255 CCOc1ccc(cc1NC(=O)C)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B10 compound treatment 7645920.0 -231649.65517241 -0.256137420504049 -0.2561 -1.0 1518737 TimTec1_004256 CCC(=O)N1N=C2CC(C)(C)OCC2C1c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B11 compound treatment 8679080.0 801510.34482759 0.88623828116063 0.8862 1.0 1335526 TimTec1_004257 CCOC(=O)c1nnn(c1CN2CCSCC2)c3nonc3N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B12 compound treatment 8335960.0 458390.34482759 0.506846947044729 0.5068 1.0 1291333 TimTec1_004258 CC1(C)NN(C(=S)N1)c2nc3ccccc3s2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B13 compound treatment 7642880.0 -234689.65517241 -0.259498779957629 -0.2595 -1.0 1385793 TimTec1_004259 Cc1nn(c(O)c1C2CC(=O)N(C2=O)c3ccccc3)c4cccc(Cl)c4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B14 compound treatment 7533560.0 -344009.65517241 -0.380375035044917 -0.3804 -1.0 1213104 TimTec1_004260 CC(CC(=O)C1C(C)C=CCC1(C)C)Nc2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B15 compound treatment 8250720.0 373150.34482759 0.412596197102902 0.4126 1.0 3212233 TimTec1_004261 CN/C(=N\C)/SC1CC(=O)N(C1=O)c2ccccc2F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B16 compound treatment 7173640.0 -703929.65517241 -0.778342302983234 -0.7783 -1.0 1345990 TimTec1_004262 CCC(=O)Nc1ccccc1C(=O)OCC(=O)Nc2nc3ccc(cc3s2)C(=O)OC 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B17 compound treatment 8341320.0 463750.34482759 0.512773554502357 0.5128 1.0 1326177 TimTec1_004263 COc1cccc2c(CCN)c[nH]c12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B18 compound treatment 301640.0 -7575929.65517241 -8.37678380462836 -8.3768 -1.0 3085165 TimTec1_004264 CCC1=C(C)/C(=C\c2[nH]c(C)c(CC)c2C)/N=C1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B19 compound treatment 7630040.0 -247529.65517241 -0.273696100807618 -0.2737 -1.0 3212234 TimTec1_004265 CCOc1cc(/C=C/2\OC(=O)c3c2cc(C)[nH]c3=S)ccc1O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B20 compound treatment 7359680.0 -517889.65517241 -0.572635950106916 -0.5726 -1.0 1379087 TimTec1_004266 Cc1ccc(OCc2nn(CN3CCC4(CC3)OCCO4)c(=S)n2C)cc1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B21 compound treatment 8041400.0 163830.34482759 0.18114890735838 0.1811 1.0 1413553 TimTec1_004267 CCC(Sc1nnc(C)c(=O)[nH]1)C(=O)Nc2ccccc2C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B22 compound treatment 7258720.0 -618849.65517241 -0.684268466696859 -0.6843 -1.0 3212308 TimTec1_004268 COc1ccc(Br)cc1S(=O)(=O)NCCCN2CCOCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B23 mock treatment 7270920.0 -606649.65517241 -0.670778800468677 -0.6708 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 B24 mock treatment 6558840.0 -1318729.65517241 -1.45813302405591 -1.4581 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C01 compound treatment 7090920.0 -786649.65517241 -0.869806662851698 -0.8698 -1.0 1539639 TimTec1_004269 COc1ccc(cc1)C(N)CC(=O)O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C02 compound treatment 6220000.0 -1657569.65517241 -1.83279191788848 -1.8328 -1.0 1192605 TimTec1_004270 O=C(NCCc1ccccc1)c2ccc(o2)C(=O)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C03 compound treatment 6705520.0 -1172049.65517241 -1.29594743042068 -1.2959 -1.0 3085169 TimTec1_004271 NC/1=C(C#N)C(=N)S\C1=C\c2ccc(Cl)c(Cl)c2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C04 compound treatment 7171280.0 -706289.65517241 -0.780951779401145 -0.781 -1.0 3212309 TimTec1_004272 CCCCC(CC)CNC1=NS(=O)(=O)c2ccccc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C05 compound treatment 7471240.0 -406329.65517241 -0.449282903843306 -0.4493 -1.0 1436367 TimTec1_004273 CSc1nc2nc(N)nc(N)c2s1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C06 compound treatment 7902960.0 25390.3448275896 0.0280743669789053 0.0281 1.0 3212310 TimTec1_004274 COc1ccc(Cc2nnc(S)s2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C07 compound treatment 8341320.0 463750.34482759 0.512773554502357 0.5128 1.0 3085173 TimTec1_004275 OC(=O)CSC1=CC(=O)N(C1=O)c2cccc(Cl)c2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C08 compound treatment 8353800.0 476230.34482759 0.526572819627579 0.5266 1.0 1438726 TimTec1_004276 Cc1ccnc(c1)N2C(=O)OC(C)(C)C2(C)O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C09 compound treatment 7909520.0 31950.3448275896 0.0353278268524199 0.0353 1.0 1517107 TimTec1_004277 CC(=O)N1CCN2C(=O)C1CCCC(=O)c3cc(ccc23)C4CCCCC4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C10 compound treatment 7761480.0 -116089.65517241 -0.128361532854149 -0.1284 -1.0 1430711 TimTec1_004278 COC(=O)c1cccc(NC(=O)COC(=O)c2cc3ccccc3o2)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C11 compound treatment 7972640.0 95070.3448275896 0.105120263928066 0.1051 1.0 1141099 TimTec1_004279 OC(=O)CCS(=O)(=O)c1ccc2ccccc2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C12 compound treatment 8700040.0 822470.34482759 0.909413970024786 0.9094 1.0 3085175 TimTec1_004280 Cc1cccc(c1)n2nn[nH]c2=S 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C13 compound treatment 7472200.0 -405369.65517241 -0.448221421910596 -0.4482 -1.0 3212311 TimTec1_004281 Brc1ccc(/C=C/2\C(=O)NN(C2=O)c3ccccc3)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C14 compound treatment 7818480.0 -59089.6551724104 -0.065336043099526 -0.0653 -1.0 1600116 TimTec1_004282 NS(=O)(=O)c1ncn(Cc2ccccc2)n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C15 compound treatment 7735120.0 -142449.65517241 -0.157508057589796 -0.1575 -1.0 1916017 TimTec1_004283 Nc1ccc(cc1)c2cnc(nc2)c3ccc(N)cc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C16 compound treatment 7618360.0 -259209.65517241 -0.286610797655583 -0.2866 -1.0 1129774 TimTec1_004284 CCOC(=O)c1oc2ccccc2c1NC(=O)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C17 compound treatment 5668680.0 -2208889.65517241 -2.44239214616074 -2.4424 -1.0 1248984 TimTec1_004285 COc1ccc(NC(=O)c2ccc3ccccc3c2OC)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C18 compound treatment 7868000.0 -9569.65517241042 -0.0105812667372637 -0.0106 -1.0 3085247 TimTec1_004286 CC(NC(=O)Nc1ccccc1Br)(C(F)(F)F)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C19 compound treatment 8220960.0 343390.34482759 0.37969025718891 0.3797 1.0 1510374 TimTec1_004287 COc1ccc(NC(=O)C2CCC(=O)N2C(=O)OCc3ccccc3)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C20 compound treatment 8035480.0 157910.34482759 0.174603102106672 0.1746 1.0 3085249 TimTec1_004288 CC1(C)Cc2ccccc2C(=N1)N3CCOCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C21 compound treatment 7806920.0 -70649.6551724104 -0.0781180547059023 -0.0781 -1.0 1404871 TimTec1_004289 O=C(N1CCSC1c2ccccc2)c3cc4ccccc4oc3=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C22 compound treatment 7312920.0 -564649.65517241 -0.624338965912638 -0.6243 -1.0 1143185 TimTec1_004290 CC(C)(C)C(=O)N1CCCC1C(=O)Nc2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C23 mock treatment 6906760.0 -970809.65517241 -1.07343428027646 -1.0734 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 C24 mock treatment 6953040.0 -924529.65517241 -1.02226200543709 -1.0223 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D01 compound treatment 7268200.0 -609369.65517241 -0.673786332611354 -0.6738 -1.0 3212312 TimTec1_004291 CCC(SC1=NC(=O)C(C(=O)N1)c2ccccc2)C(=O)Nc3sc4CCCCc4c3C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D02 compound treatment 7513520.0 -364049.65517241 -0.402533470390227 -0.4025 -1.0 1681507 TimTec1_004292 S=C(SCc1ccc(CSC(=S)N2CCOCC2)cc1)N3CCOCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D03 compound treatment 7824160.0 -53409.6551724104 -0.0590556083309951 -0.0591 -1.0 1369855 TimTec1_004293 CCC(=O)N1CCC(CC1)C(=O)O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D04 compound treatment 7970040.0 92470.3448275896 0.102245417026978 0.1022 1.0 1327254 TimTec1_004294 O=C1C(C(=O)c2ccccc12)C3=Nc4ccccc4NC(C3)c5ccccc5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D05 compound treatment 7624760.0 -252809.65517241 -0.27953425143752 -0.2795 -1.0 1670837 TimTec1_004295 OC(C#CCN1CCCC1)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D06 compound treatment 8048280.0 170710.34482759 0.188756194542798 0.1888 1.0 3085254 TimTec1_004296 Nc1ccc2nc(SCC(=O)c3ccc(F)cc3)sc2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D07 compound treatment 8388880.0 511310.34482759 0.565361138585337 0.5654 1.0 1149209 TimTec1_004297 Cn1ccnc1SCC(=O)Nc2ccccc2Oc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D08 compound treatment 2648080.0 -5229489.65517241 -5.78230081901715 -5.7823 -1.0 1583796 TimTec1_004298 OC(=O)c1ccc(cc1)c2cnc3ccccc3n2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D09 compound treatment 8640560.0 762990.34482759 0.843646318610664 0.8436 1.0 1479857 TimTec1_004299 Nc1ccc(OCC(=O)N2CCOCC2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D10 compound treatment 8708480.0 830910.34482759 0.918746165349857 0.9187 1.0 1457410 TimTec1_004300 C(Nc1ccc2oc(nc2c1)c3ccccc3)c4cccnc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D11 compound treatment 1925080.0 -5952489.65517241 -6.58172939958896 -6.5817 -1.0 3085258 TimTec1_004301 CC(=O)OC1(CN2CCC1CC2)C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D12 compound treatment 7897880.0 20310.3448275896 0.0224573584183178 0.0225 1.0 1325596 TimTec1_004302 CC(=O)N1C(O)C(O)N(C(=O)C)C1=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D13 compound treatment 7557800.0 -319769.65517241 -0.353572616244004 -0.3536 -1.0 3085259 TimTec1_004303 CNC(=N)NC(=O)Nc1c(C)cccc1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D14 compound treatment 8760160.0 882590.34482759 0.975889276060716 0.9759 1.0 1635468 TimTec1_004304 COc1ccc2n(c(C)c(C(=O)N3CCN(C)CC3)c2c1)c4ccccc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D15 compound treatment 9027760.0 1150190.34482759 1.27177736480347 1.2718 1.0 1665310 TimTec1_004305 CC1(C)CC(=O)CC(=C1)NCC2CCCO2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D16 compound treatment 7178800.0 -698769.65517241 -0.772636837594921 -0.7726 -1.0 1262068 TimTec1_004306 Cc1cc(=O)oc2c3c(OC(=O)c4ccccc4)coc3c(NC(=O)c5ccccc5)cc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D17 compound treatment 8843760.0 966190.34482759 1.06832666103416 1.0683 1.0 1639736 TimTec1_004307 CC(C)OC(=O)C1C(C2CC1C=C2)C(=O)NCC=C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D18 compound treatment 8515480.0 637910.34482759 0.705344068461395 0.7053 1.0 3212313 TimTec1_004308 O=C(CSc1nnc[nH]1)C2CC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D19 compound treatment 8274880.0 397310.34482759 0.43931015907609 0.4393 1.0 1018938 TimTec1_004309 O=C(N1CCN(CC1)C(=O)c2ccccc2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D20 compound treatment 8117760.0 240190.34482759 0.265580949422644 0.2656 1.0 1028190 TimTec1_004310 COc1ccc(CC(O)CN2CCOCC2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D21 compound treatment 8192200.0 314630.34482759 0.347890027621489 0.3479 1.0 1610412 TimTec1_004311 CC(C)(C)OC(=O)N1CC(O)CC1C(=O)N2CCOCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D22 compound treatment 8198280.0 320710.34482759 0.354612746528649 0.3546 1.0 1636298 TimTec1_004312 Cn1ccnc1SCC(=O)N2c3ccccc3CCc4ccccc24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D23 mock treatment 7917080.0 39510.3448275896 0.0436869970725068 0.0437 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 D24 mock treatment 7375880.0 -501689.65517241 -0.554723442492444 -0.5547 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E01 compound treatment 7455040.0 -422529.65517241 -0.467195411457777 -0.4672 -1.0 3212314 TimTec1_004313 CC(=O)NCC(c1ccccc1)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E02 compound treatment 8429040.0 551470.34482759 0.609766466103682 0.6098 1.0 1202468 TimTec1_004314 O=C(NCN1CCN(Cc2ccccc2)CC1)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E03 compound treatment 4396640.0 -3480929.65517241 -3.84889993541462 -3.8489 -1.0 3085337 TimTec1_004315 COc1ccc(/N=C/c2ccc(Sc3ccccn3)o2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E04 compound treatment 8261280.0 383710.34482759 0.424272498362706 0.4243 1.0 1420647 TimTec1_004316 O=C(COC(=O)c1ccco1)N2c3ccccc3Sc4ccccc24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E05 compound treatment 8071520.0 193950.34482759 0.214452902997139 0.2145 1.0 1547103 TimTec1_004317 CC(N1C(=O)CCC1=O)C(=O)Oc2ccc3c(C)cc(=O)oc3c2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E06 compound treatment 9276760.0 1399190.34482759 1.54709924109999 1.5471 1.0 1714581 TimTec1_004318 Cc1ccc(CCP(=O)(O)CN2CCCCC2)cn1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E07 compound treatment 7995280.0 117710.34482759 0.130153546174464 0.1302 1.0 3085340 TimTec1_004319 Cc1ccc(NC(=O)CC2CCC2)cc1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E08 compound treatment 8344640.0 467070.34482759 0.516444512852977 0.5164 1.0 3212315 TimTec1_004320 Cc1cc(C)nc(n1)N2C(=C)C(C)(C)OC2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E09 compound treatment 9229160.0 1351590.34482759 1.49446742860314 1.4945 1.0 3085343 TimTec1_004321 Cc1sc(/N=C/c2ccc(Cl)c(Cl)c2)c(C#N)c1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E10 compound treatment 2054360.0 -5823209.65517241 -6.43878316598409 -6.4388 -1.0 1671390 TimTec1_004322 Ic1ccc(Nc2nc3nonc3n4nnnc24)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E11 compound treatment 8054400.0 176830.34482759 0.195523141863821 0.1955 1.0 1687107 TimTec1_004323 CN1CCC(O)(CC1)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E12 compound treatment 8720680.0 843110.34482759 0.93223583157804 0.9322 1.0 1215551 TimTec1_004324 COC(=O)C1=C(N)N(C2=C(C1c3ccc(OC)cc3)C(=O)CCC2)c4ccc(cc4)S(=O)(=O)N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E13 compound treatment 7670840.0 -206729.65517241 -0.228583118667466 -0.2286 -1.0 1516816 TimTec1_004325 Clc1cccc(OCCN2CCN(CC2)c3ccccc3)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E14 compound treatment 8129800.0 252230.34482759 0.278893701995375 0.2789 1.0 3212316 TimTec1_004326 O=C(CCCc1ccccc1)NC2CC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E15 compound treatment 8858160.0 980590.34482759 1.0842488900248 1.0842 1.0 1919871 TimTec1_004327 CCS(=O)(=O)C(=C1Nc2ccccc2N1)S(=O)(=O)CC 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E16 compound treatment 8398480.0 520910.34482759 0.575975957912432 0.576 1.0 1212477 TimTec1_004328 CCOC(=O)C1=C(C)OC(=C(C#N)C21C(=O)Nc3ccc(C)cc32)N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E17 compound treatment 9343400.0 1465830.34482759 1.62078377859557 1.6208 1.0 3212317 TimTec1_004329 Nc1ccnc(c1C(=O)c2ccccc2)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E18 compound treatment 8575320.0 697750.34482759 0.771509775600284 0.7715 1.0 1147665 TimTec1_004330 Fc1ccccc1C(=O)Nc2ccc3nc(SCC(=O)NC4CC4)sc3c2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E19 compound treatment 7636800.0 -240769.65517241 -0.266221498864789 -0.2662 -1.0 1323101 TimTec1_004331 COC(=O)c1c(CC=C(C)C)c(C)nc2ccccc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E20 compound treatment 8398200.0 520630.34482759 0.575666359015391 0.5757 1.0 3212392 TimTec1_004332 CC1CN=C(S1)N(Cc2ccccc2Cl)C(=O)Nc3cccc(Cl)c3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E21 compound treatment 8517280.0 639710.34482759 0.707334347085225 0.7073 1.0 3085349 TimTec1_004333 S=c1[nH]nc(Cc2ccccc2)[nH]1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E22 compound treatment 7549480.0 -328089.65517241 -0.362772126327486 -0.3628 -1.0 1488335 TimTec1_004334 O=C(CSc1ncnc2[nH]cnc12)c3ccc4ccccc4c3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E23 mock treatment 8312720.0 435150.34482759 0.481150238590388 0.4812 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 E24 mock treatment 7561560.0 -316009.65517241 -0.349415145340892 -0.3494 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F01 compound treatment 4409920.0 -3467649.65517241 -3.83421610201214 -3.8342 -1.0 3085351 TimTec1_004335 Cc1ccnc(NC(=O)c2cccs2)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F02 compound treatment 7919040.0 41470.3448275896 0.0458541893517885 0.0459 1.0 3085353 TimTec1_004336 CSc1ncc(F)c(n1)N(C)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F03 compound treatment 6623160.0 -1254409.65517241 -1.38701373456438 -1.387 -1.0 3212393 TimTec1_004337 CCC(Sc1ccccn1)C(=O)Nc2cccc3ccccc23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F04 compound treatment 9144880.0 1267310.34482759 1.40127816059403 1.4013 1.0 3084406 TimTec1_004338 Nc1ccc(OCCOc2ccc(N)cc2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F05 compound treatment 8051760.0 174190.34482759 0.19260406654887 0.1926 1.0 1262298 TimTec1_004339 Fc1ccc(CNC(=O)C2CN(C(=O)C2)c3ccc(F)cc3)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F06 compound treatment 8177600.0 300030.34482759 0.331746656561533 0.3317 1.0 3212394 TimTec1_004340 CN(CC(COc1ccccc1)OC(=O)c2ccc(Cl)cc2)C3=NS(=O)(=O)c4ccccc34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F07 compound treatment 3929360.0 -3948209.65517241 -4.36557626616095 -4.3656 -1.0 1118159 TimTec1_004341 Cc1ccc(OCCN)c(Br)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F08 compound treatment 8749280.0 871710.34482759 0.963859147490008 0.9639 1.0 1694465 TimTec1_004342 COc1ccc(cc1)c2nn(CO)c(=S)n2c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F09 compound treatment 8188160.0 310590.34482759 0.343422957821337 0.3434 1.0 3084411 TimTec1_004343 O=S1(=O)N=C(N2CCNCC2)c3ccccc31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F10 compound treatment 7765800.0 -111769.65517241 -0.123584864156957 -0.1236 -1.0 1406499 TimTec1_004344 Cc1cc(C)c(COC(=O)c2nonc2N)c(C)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F11 compound treatment 8438800.0 561230.34482759 0.620558199086228 0.6206 1.0 1497656 TimTec1_004345 CC1(C)CC(=O)C(C(O)c2ccccc2)C(C)(C)N1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F12 compound treatment 8006760.0 129190.34482759 0.142847100953114 0.1428 1.0 3084413 TimTec1_004346 O=C(CSc1nnc(o1)c2ccccc2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F13 compound treatment 8080280.0 202710.34482759 0.224138925633113 0.2241 1.0 1560213 TimTec1_004347 Clc1cccc(NC(=O)NC2CCN(C2)C3CCCCC3)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F14 compound treatment 7955840.0 78270.3448275896 0.0865443301056507 0.0865 1.0 3084415 TimTec1_004348 Cc1cn(C(=O)c2ccc(Cl)cc2Cl)c(C)n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F15 compound treatment 8769040.0 891470.34482759 0.985707983938278 0.9857 1.0 1406332 TimTec1_004349 O=C(CSc1nc2ccc(NC(=O)C3CCCCC3)cc2s1)NCC4CCCO4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F16 compound treatment 7965200.0 87630.3448275896 0.0968937789495678 0.0969 1.0 3212395 TimTec1_004350 O=C1C2C(C3=C(CCCC3=O)N=C2c4ccccc14)c5cccs5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F17 compound treatment 9456640.0 1579070.34482759 1.74599441824142 1.746 1.0 1570773 TimTec1_004351 CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)N2CCNCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F18 compound treatment 8651160.0 773590.34482759 0.85536684828433 0.8554 1.0 1621338 TimTec1_004352 O=C(CSc1nc2ccccc2[nH]1)C3CC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F19 compound treatment 8929800.0 1052230.34482759 1.16346197925325 1.1635 1.0 1630047 TimTec1_004353 O=S1(=O)CCC(C1)N2CCOCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F20 compound treatment 8469960.0 592390.34482759 0.655012133485422 0.655 1.0 1536902 TimTec1_004354 Cc1ccc(cc1)C(=O)C2C(=O)OC(=CC2=O)c3ccc(C)cc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F21 compound treatment 8113280.0 235710.34482759 0.26062736707 0.2606 1.0 1248516 TimTec1_004355 Nc1nnc(SCC(=O)N2CCCCC2)s1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F22 compound treatment 7879520.0 1950.34482758958 0.00215651645524965 0.0022 1.0 3084420 TimTec1_004356 O=c1/c(=C\c2ccncc2)/sc3nc4ccccc4n13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F23 mock treatment 8454880.0 577310.34482759 0.638338021459111 0.6383 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 F24 mock treatment 7733240.0 -144329.65517241 -0.159586793041352 -0.1596 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G01 compound treatment 7528520.0 -349049.65517241 -0.385947815191642 -0.3859 -1.0 1052156 TimTec1_004357 O=S(=O)(Nc1ccccn1)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G02 compound treatment 7737360.0 -140209.65517241 -0.155031266413474 -0.155 -1.0 1455699 TimTec1_004358 CC1(C)CC(CC(C)(C)N1)NC(=O)c2ccc(o2)C(=O)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G03 compound treatment 7986360.0 108790.34482759 0.120290609883039 0.1203 1.0 3084422 TimTec1_004359 CCc1ccc2oc(nc2c1)c3cc(/N=C\c4ccccc4O)ccc3O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G04 compound treatment 8017240.0 139670.34482759 0.154434945385192 0.1544 1.0 3212396 TimTec1_004360 CSc1nsc(SC)c1NC(=O)Nc2ccccn2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G05 compound treatment 8554360.0 676790.34482759 0.748334086736128 0.7483 1.0 3084424 TimTec1_004361 O=C(CCCCN1CCCCC1)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G06 compound treatment 8957440.0 1079870.34482759 1.19402381323251 1.194 1.0 3212397 TimTec1_004362 FC(F)(F)C(NC(=O)c1ccccc1)(N2CCOCC2)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G07 compound treatment 9608200.0 1730630.34482759 1.91357587836792 1.9136 1.0 1644204 TimTec1_004363 CC(C)Nc1nc(Cl)nc(NC(C)(C)CO)n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G08 compound treatment 8641680.0 764110.34482759 0.844884714198825 0.8449 1.0 1320611 TimTec1_004364 O=C(Nc1ccccn1)c2cccc(c2)N3C(=O)CCC3=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G09 compound treatment 8839440.0 961870.34482759 1.06354999233697 1.0635 1.0 1019380 TimTec1_004365 C(N1CCCCC1)c2c[nH]c3ccccc23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G10 compound treatment 8954040.0 1076470.34482759 1.19026439805416 1.1903 1.0 1557179 TimTec1_004366 OC(=O)CCn1c2ccccc2c3ccccc13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G11 compound treatment 8576320.0 698750.34482759 0.772615485946856 0.7726 1.0 1693338 TimTec1_004367 COc1ccc(cc1)c2ncccc2O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G12 compound treatment 8866800.0 989230.34482759 1.09380222741919 1.0938 1.0 1612647 TimTec1_004368 NNC(=O)c1ccc(OCC(O)CO)cc1O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G13 compound treatment 9559040.0 1681470.34482759 1.85921915773043 1.8592 1.0 1723169 TimTec1_004369 CCN(CC)c1ccc(Nc2cc(C)c(C#N)c3nc4ccccc4n23)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G14 compound treatment 9957000.0 2079430.34482759 2.29924764725236 2.2992 1.0 3084439 TimTec1_004370 N/C(=N\O)/c1cccc(n1)\C(=N\O)\N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G15 compound treatment 9172680.0 1295110.34482759 1.43201690822874 1.432 1.0 3212398 TimTec1_004371 Cn1c2N(CC(=O)c2c(=O)n(C)c1=O)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G16 compound treatment 8287920.0 410350.34482759 0.453728621995393 0.4537 1.0 3084441 TimTec1_004372 C(Sc1nnc(SCc2ccccn2)s1)c3ccccn3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G17 compound treatment 8462960.0 585390.34482759 0.647272161059416 0.6473 1.0 3212399 TimTec1_004373 Fc1ccc(cc1)c2cc(nc(SCC(=O)Oc3ccccc3)c2C#N)c4ccco4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G18 compound treatment 9335800.0 1458230.34482759 1.61238037996162 1.6124 1.0 1717375 TimTec1_004374 O=C(CCSc1nccn1Cc2ccccc2)NC3CCCCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G19 compound treatment 9296520.0 1418950.34482759 1.56894807754826 1.5689 1.0 3084443 TimTec1_004375 Cc1cc(C)nc(SCC(=O)c2c(N)no[n+]2[O-])n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G20 compound treatment 9059680.0 1182110.34482759 1.30707163906606 1.3071 1.0 3212400 TimTec1_004376 CC1CN=C(S1)N(C(=O)Nc2ccc(Cl)cc2)c3cccc(C)n3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G21 compound treatment 8605720.0 728150.34482759 0.805123370136083 0.8051 1.0 3084445 TimTec1_004377 CC(C)C(=O)NC1=NC2C(N=CN2C3CC(O)C(CO)O3)C(=N1)O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G22 compound treatment 8759480.0 881910.34482759 0.975137393025046 0.9751 1.0 3212401 TimTec1_004378 O=C1CN(C=NN1)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G23 mock treatment 8311320.0 433750.34482759 0.479602244105186 0.4796 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 G24 mock treatment 7584080.0 -293489.65517241 -0.324514548336083 -0.3245 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H01 compound treatment 7576240.0 -301329.65517241 -0.33318331745321 -0.3332 -1.0 1333222 TimTec1_004379 COc1ccccc1NCn2c(=O)sc3ccccc23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H02 compound treatment 8298320.0 420750.34482759 0.465228009599746 0.4652 1.0 1378323 TimTec1_004380 CSc1ncc(F)c(n1)N(CCO)CCO 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H03 compound treatment 8438320.0 560750.34482759 0.620027458119873 0.62 1.0 1426454 TimTec1_004381 O=C(CNC(=O)C(c1ccccc1)c2ccccc2)NC3CCCCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H04 compound treatment 8688040.0 810470.34482759 0.896145445865918 0.8961 1.0 3084448 TimTec1_004382 Cc1ccc(cc1)P(=O)(C)c2ccc(C)cc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H05 compound treatment 8982760.0 1105190.34482759 1.22202039920772 1.222 1.0 1325975 TimTec1_004383 O=c1n(CCc2ccccn2)nc(c3ccccc3)c4ccccc14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H06 compound treatment 9586480.0 1708910.34482759 1.88955984964037 1.8896 1.0 1363120 TimTec1_004384 OC(COc1ccccc1)CS(=O)(=O)c2ccccn2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H07 compound treatment 9045280.0 1167710.34482759 1.29114941007542 1.2911 1.0 1512838 TimTec1_004385 CSCCC1NC(=S)N(Cc2ccccc2)C1=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H08 compound treatment 8819440.0 941870.34482759 1.04143578540552 1.0414 1.0 1461248 TimTec1_004386 Fc1ccc(cc1)C(=O)Nc2ccc3C(=O)OCc3c2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H09 compound treatment 8760840.0 883270.34482759 0.976641159096385 0.9766 1.0 1264638 TimTec1_004387 Oc1ccc2occ(C(=O)c3cccs3)c2c1CN4CCOCC4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H10 compound treatment 9547640.0 1670070.34482759 1.8466140597795 1.8466 1.0 1248397 TimTec1_004388 CCSc1nc2ccccc2n1CC(=O)N3CCCCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H11 compound treatment 8953640.0 1076070.34482759 1.18982211391553 1.1898 1.0 3084452 TimTec1_004389 O=C(OC[C@@H]1CCCN2CCCCC12)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H12 compound treatment 9399760.0 1522190.34482759 1.68310161372838 1.6831 1.0 3212402 TimTec1_004390 CCOC(=O)c1[nH]c(COC(=O)C)cc1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H13 compound treatment 9382840.0 1505270.34482759 1.66439299466438 1.6644 1.0 1294077 TimTec1_004391 COc1ccc(cc1)C(=O)c2coc3ccc(OC)cc3c2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H14 compound treatment 9659080.0 1781510.34482759 1.96983442080152 1.9698 1.0 1370478 TimTec1_004392 Fc1cc2c(=O)cc[nH]c2cc1N3CCOCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H15 compound treatment 9253360.0 1375790.34482759 1.52122561899019 1.5212 1.0 1351428 TimTec1_004393 Cc1ccc(cc1)S(=O)(=O)N2CC(=O)N(O)C2c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H16 compound treatment 7984360.0 106790.34482759 0.118079189189894 0.1181 1.0 3084456 TimTec1_004394 FC(F)(F)c1ccc2sc(S)nc2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H17 compound treatment 9175720.0 1298150.34482759 1.43537826768232 1.4354 1.0 1715297 TimTec1_004395 N#CC(CCN1CCNCC1)(c2ccccc2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H18 compound treatment 9100720.0 1223150.34482759 1.35244999168939 1.3524 1.0 1355787 TimTec1_004396 OCCN(CCO)C(=O)CCc1[nH]c2ccccc2c1Sc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H19 compound treatment 9718280.0 1840710.34482759 2.03529247331861 2.0353 1.0 3212474 TimTec1_004397 Clc1ccc(NC(=O)CSC2=NC(=O)C(C(=O)N2)c3ccccc3)nc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H20 compound treatment 9018640.0 1141070.34482759 1.26169328644273 1.2617 1.0 3084461 TimTec1_004398 CC1CNc2ccccc2N=C1N3CCOCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H21 compound treatment 3972960.0 -3904609.65517241 -4.31736729505039 -4.3174 -1.0 3212475 TimTec1_004399 S=c1[nH]cnc2n(CN3CCCCC3)cnc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H22 compound treatment 8484120.0 606550.34482759 0.670668991992887 0.6707 1.0 1451020 TimTec1_004400 OC1=C(C(=O)c2ccccc2)C3(O)N(C1=O)c4ccccc4OC3=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H23 mock treatment 8287360.0 409790.34482759 0.453109424201313 0.4531 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 H24 mock treatment 7161400.0 -716169.65517241 -0.79187619762528 -0.7919 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I01 compound treatment 8185440.0 307870.34482759 0.34041542567866 0.3404 1.0 3084463 TimTec1_004401 C/C(=N\N)/c1nnn(c1C)c2nonc2N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I02 compound treatment 8025920.0 148350.34482759 0.16403251119344 0.164 1.0 1525911 TimTec1_004402 OP(=O)(CCc1ccccn1)CN2CCOCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I03 compound treatment 4675960.0 -3201609.65517241 -3.54005292141004 -3.5401 -1.0 1170438 TimTec1_004403 CCN(CC)S(=O)(=O)c1ccc(cc1)c2csc(Nc3cccc(OC)c3)n2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I04 compound treatment 8645680.0 768110.34482759 0.849307555585114 0.8493 1.0 1584075 TimTec1_004404 O=C(C1C2C1C(=O)C3OCC2O3)c4cccs4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I05 compound treatment 8214000.0 336430.34482759 0.371994513176766 0.372 1.0 1217640 TimTec1_004405 CN(C)Cc1cc2ccccc2[nH]1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I06 compound treatment 9566920.0 1689350.34482759 1.86793215526142 1.8679 1.0 1227632 TimTec1_004406 N#CCCn1c(nc2ccccc12)C3CCCCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I07 compound treatment 8183120.0 305550.34482759 0.337850177674612 0.3379 1.0 1733675 TimTec1_004407 Cc1ccc(cc1C)N2NC(=O)CC2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I08 compound treatment 9354840.0 1477270.34482759 1.63343310496036 1.6334 1.0 1603161 TimTec1_004408 COC(=O)c1ccc(NC(=O)COC(=O)c2cc3ccccc3o2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I09 compound treatment 8830240.0 952670.34482759 1.05337745714851 1.0534 1.0 1037174 TimTec1_004409 CCOC(=O)c1cc(C(=O)OCC)c(C)nc1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I10 compound treatment 9886640.0 2009070.34482759 2.22144986726753 2.2214 1.0 1467402 TimTec1_004410 COc1ccc(NC(=O)CSc2ccc3ccccc3n2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I11 compound treatment 9192120.0 1314550.34482759 1.4535119173661 1.4535 1.0 1668645 TimTec1_004411 O=C(Nc1cccc2ccccc12)OC3CCS(=O)(=O)C3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I12 compound treatment 9856240.0 1978670.34482759 2.18783627273173 2.1878 1.0 3212476 TimTec1_004412 Cc1cc2/C(=C\c3ccc(Cl)c(Cl)c3)/OC(=O)c2c(=S)[nH]1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I13 compound treatment 8932280.0 1054710.34482759 1.16620414091275 1.1662 1.0 1917148 TimTec1_004413 O=c1[nH]c2ccc(/N=C/c3ccc(C#Cc4ccccc4)cc3)cc2o1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I14 compound treatment 9267160.0 1389590.34482759 1.53648442177289 1.5365 1.0 1236087 TimTec1_004414 O=C(C1CN2CCC1CC2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I15 compound treatment 8390800.0 513230.34482759 0.567484102450756 0.5675 1.0 1912326 TimTec1_004415 CCOC(=O)C(C#N)C(=O)c1ccc(N)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I16 compound treatment 8577240.0 699670.34482759 0.773632739465703 0.7736 1.0 1609648 TimTec1_004416 CCCC(OC(=O)C)C#CCN1CCCCC1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I17 compound treatment 9039920.0 1162350.34482759 1.28522280261779 1.2852 1.0 3084472 TimTec1_004417 COC(=O)CSc1nsc(SCC(=O)OC)c1C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I18 compound treatment 8569200.0 691630.34482759 0.764742828279261 0.7647 1.0 3212477 TimTec1_004418 CCC(Sc1nc(C)cc(C)n1)C(=O)Nc2sc3CCCCc3c2C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I19 compound treatment 8973200.0 1095630.34482759 1.21144980829449 1.2114 1.0 1539203 TimTec1_004419 CCC1CCCCN1C(=O)c2cc3ccccc3oc2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I20 compound treatment 8667520.0 789950.34482759 0.873456269554254 0.8735 1.0 1728922 TimTec1_004420 Nc1nonc1C(=O)OCC(=O)N2CCOCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I21 compound treatment 8379440.0 501870.34482759 0.554923232913694 0.5549 1.0 1427907 TimTec1_004421 CCOc1ccc(OCC)c(c1)C(=O)C2CCCCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I22 compound treatment 8308360.0 430790.34482759 0.476329341479332 0.4763 1.0 1647970 TimTec1_004422 CCC(OC(=O)C)C#CCN1CCOCC1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I23 mock treatment 8433760.0 556190.34482759 0.614985418939504 0.615 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 I24 mock treatment 7672560.0 -205009.65517241 -0.226681296871362 -0.2267 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J01 compound treatment 7491880.0 -385689.65517241 -0.426461042290052 -0.4265 -1.0 3084477 TimTec1_004423 Cn1nnnc1SCC(=O)NC(C)(C)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J02 compound treatment 8476720.0 599150.34482759 0.662486735428251 0.6625 1.0 3084491 TimTec1_004424 Cn1c(=O)nc2n(c3cccc(c3)C(F)(F)F)c4ccccc4cc2c1=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J03 compound treatment 7382440.0 -495129.65517241 -0.547469982618929 -0.5475 -1.0 3084494 TimTec1_004425 Oc1ccccc1C(=O)N2N=C(CC2(O)C(F)(F)F)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J04 compound treatment 8086840.0 209270.34482759 0.231392385506627 0.2314 1.0 1706033 TimTec1_004426 OC(=O)c1cccc(NC(=O)CC(=O)c2ccccc2)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J05 compound treatment 8634600.0 757030.34482759 0.837056284945092 0.8371 1.0 1279425 TimTec1_004427 CCCC(=O)Nc1nnc(Cc2ccc(Cl)cc2)s1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J06 compound treatment 8411720.0 534150.34482759 0.590615562901049 0.5906 1.0 1425542 TimTec1_004428 Fc1ccc(NC(=O)C2C3C2C4CCC3C4)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J07 compound treatment 8457840.0 580270.34482759 0.641610924084966 0.6416 1.0 1301943 TimTec1_004429 Cc1[nH]c(=S)c(C#N)c(C)c1CC(=O)c2ccc(Br)cc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J08 compound treatment 8930360.0 1052790.34482759 1.16408117704733 1.1641 1.0 1313319 TimTec1_004430 COc1ccc(NC(=O)CC2SCCNC2=O)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J09 compound treatment 7766600.0 -110969.65517241 -0.122700295879699 -0.1227 -1.0 1169823 TimTec1_004431 CCN(CC)c1nc(Nc2ccccc2OC)nc(Nc3cc(C)ccc3C)n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J10 compound treatment 9403240.0 1525670.34482759 1.68694948573446 1.6869 1.0 3084499 TimTec1_004432 Cc1ccc(cc1)n2c(SCC=C)nc3sc4CCCc4c3c2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J11 compound treatment 6705880.0 -1171689.65517241 -1.29554937469591 -1.2955 -1.0 1249197 TimTec1_004433 CCOC(=O)N1CCc2[nH]c3ccccc3c2C1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J12 compound treatment 8239360.0 361790.34482759 0.400035327565841 0.4 1.0 1223335 TimTec1_004434 COc1ccc(Cl)cc1NC(=O)CCN2CCN(CC2)c3ccccc3C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J13 compound treatment 5876240.0 -2001329.65517241 -2.21289090662619 -2.2129 -1.0 1680037 TimTec1_004435 O=c1cc(Nc2ccc(cc2)N3CCCCC3)[nH]c(=O)[nH]1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J14 compound treatment 9541400.0 1663830.34482759 1.83971442721689 1.8397 1.0 1142790 TimTec1_004436 Cc1ccc(cc1C)N(Cc2ccc(cc2)C(=O)N3CCOCC3)S(=O)(=O)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J15 compound treatment 7483600.0 -393969.65517241 -0.435616323959671 -0.4356 -1.0 1406310 TimTec1_004437 CCCNc1nc(NC2CCCCC2)nc(OC(C)C)n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J16 compound treatment 8758640.0 881070.34482759 0.974208596333926 0.9742 1.0 3212719 TimTec1_004438 CCC(=O)NC(Nc1sc2CCCCc2c1C(=O)N)(C(F)(F)F)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J17 compound treatment 9203880.0 1326310.34482759 1.46651507104179 1.4665 1.0 1448396 TimTec1_004439 CC(C)C(NC(=O)C(c1ccccc1)c2ccccc2)C(=O)N3CCOCC3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J18 compound treatment 8649040.0 771470.34482759 0.853022742349597 0.853 1.0 1655510 TimTec1_004440 Cc1ccccc1Nc2nc(Nc3ccccc3C)nc(Sc4nccn4C)n2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J19 compound treatment 9270280.0 1392710.34482759 1.5399342380542 1.5399 1.0 1576794 TimTec1_004441 CC(=O)N(Cc1ccc(cc1)S(=O)(=O)N)C2CC(=O)N(C2=O)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J20 compound treatment 8715640.0 838070.34482759 0.926663051431315 0.9267 1.0 1667869 TimTec1_004442 Cc1ccccc1OCc2nnc(SCCC(=O)O)n2Cc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J21 compound treatment 8940280.0 1062710.34482759 1.17504982368533 1.175 1.0 3212720 TimTec1_004443 OCCCc1nnc(S)n1CC=C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J22 compound treatment 8588440.0 710870.34482759 0.786016695347313 0.786 1.0 3212721 TimTec1_004444 COc1ccc(/C=N/c2ccc3[nH]c(=O)[nH]c3c2)cc1OC 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J23 mock treatment 8256080.0 378510.34482759 0.41852280456053 0.4185 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 J24 mock treatment 8171840.0 294270.34482759 0.325377764965276 0.3254 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K01 compound treatment 2396880.0 -5480689.65517241 -6.06005525807613 -6.0601 -1.0 3084505 TimTec1_004445 O=C(OCCSC1=NS(=O)(=O)c2ccccc12)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K02 compound treatment 8045440.0 167870.34482759 0.185615977158532 0.1856 1.0 3084507 TimTec1_004446 Cc1cc(C)c(C#N)c(SCC(=O)OC=C)n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K03 compound treatment 8081600.0 204030.34482759 0.225598463290588 0.2256 1.0 1649077 TimTec1_004447 O=C1OC2(CCCCC2)C(=C1)NCc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K04 compound treatment 9162120.0 1284550.34482759 1.42034060696893 1.4203 1.0 3212722 TimTec1_004448 CC1=NN(C(=O)c2ccc(Cl)cc2)C(C)(O)C1CC=C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K05 compound treatment 7846720.0 -30849.6551724104 -0.0341107829123231 -0.0341 -1.0 3212723 TimTec1_004449 COc1ccc(/C=N/C2(CC3CC4CC(C3)C2)C4)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K06 compound treatment 9528400.0 1650830.34482759 1.82534019271145 1.8253 1.0 1472188 TimTec1_004450 CCC(C)(N1CCC1=O)C(=O)Nc2cccc(C)c2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K07 compound treatment 9409480.0 1531910.34482759 1.69384911829707 1.6938 1.0 3212724 TimTec1_004451 Cc1cccc2oc(nc12)c3ccc(/N=C/c4cc(ccc4O)C(=O)O)cc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K08 compound treatment 9465280.0 1587710.34482759 1.7555477556358 1.7555 1.0 1385208 TimTec1_004452 Cc1ccc(C)c(c1)S(=O)(=O)n2ccnc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K09 compound treatment 9120120.0 1242550.34482759 1.3739007724129 1.3739 1.0 1562045 TimTec1_004453 CN(c1c(C)n(C)n(c2ccccc2)c1=O)S(=O)(=O)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K10 compound treatment 9382600.0 1505030.34482759 1.6641276241812 1.6641 1.0 3084514 TimTec1_004454 Cc1cccc(NC(=O)c2cc(ccc2Cl)N3C(=O)C=CC3=O)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K11 compound treatment 8917600.0 1040030.34482759 1.14997231302506 1.15 1.0 3212887 TimTec1_004455 CC(C)CN(C(=O)Nc1ccccc1)C2=NCC(C)S2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K12 compound treatment 9091920.0 1214350.34482759 1.34271974063956 1.3427 1.0 1735032 TimTec1_004456 COc1ccccc1Nc2nc3CCCCc3s2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K13 compound treatment 9254640.0 1377070.34482759 1.52264092823381 1.5226 1.0 1256975 TimTec1_004457 CCCCS(=O)C1CCCCC1OC(=O)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K14 compound treatment 9037240.0 1159670.34482759 1.28225949888898 1.2823 1.0 1277459 TimTec1_004458 COC(=O)CNc1nc(Cl)nc(n1)N2CCC(C)CC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K15 compound treatment 9598280.0 1720710.34482759 1.90260723172993 1.9026 1.0 1916082 TimTec1_004459 CC(=O)NC1=NN(C(S1)c2ccccc2)C(=O)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K16 compound treatment 9424760.0 1547190.34482759 1.71074437239269 1.7107 1.0 1664793 TimTec1_004460 Cc1ccc(cc1)N2C(=C(C(C3=C2CC(C)(C)CC3)c4ccc(Cl)cc4)C(=O)N)N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K17 compound treatment 9391480.0 1513910.34482759 1.67394633205877 1.6739 1.0 1554613 TimTec1_004461 CSc1nsc(SC)c1NC(=O)N2CCCCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K18 compound treatment 8407760.0 530190.34482759 0.586236949928623 0.5862 1.0 1119521 TimTec1_004462 O=C1NC(Nc2c1sc(=S)n2c3ccccc3)c4cccs4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K19 compound treatment 6699240.0 -1178329.65517241 -1.30289129139715 -1.3029 -1.0 1275123 TimTec1_004463 Nc1cc(nn1CC2CCCCC2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K20 compound treatment 7161000.0 -716569.65517241 -0.792318481763908 -0.7923 -1.0 1161548 TimTec1_004464 Cc1ccc(NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(c4ccccc4)c5ccccc5)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K21 compound treatment 8659080.0 781510.34482759 0.864124074229183 0.8641 1.0 1635937 TimTec1_004465 O=C(CSn1nnnc1c2ccccc2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K22 compound treatment 8076520.0 198950.34482759 0.219981454730001 0.22 1.0 3212796 TimTec1_004466 FC(F)(F)c1c2CCc3ccccc3-c2nc4cc(nn14)C(=O)N5CCCC5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K23 mock treatment 8431720.0 554150.34482759 0.612729769832496 0.6127 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 K24 mock treatment 8043320.0 165750.34482759 0.183271871223799 0.1833 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L01 compound treatment 8126800.0 249230.34482759 0.275576570955658 0.2756 1.0 1434454 TimTec1_004467 CC(=O)Nc1ccc(Nc2cc(C)c3ccccc3n2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L02 compound treatment 8287080.0 409510.34482759 0.452799825304273 0.4528 1.0 1330869 TimTec1_004468 CN1CC[C@@H]2[C@@H](C1)c3cc(C)ccc3N2C(=O)c4ccc(C)cc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L03 compound treatment 8435800.0 558230.34482759 0.617241068046511 0.6172 1.0 3084523 TimTec1_004469 Cc1cc(=O)oc2cc(OC(=O)CSC(=N)N)ccc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L04 compound treatment 8542160.0 664590.34482759 0.734844420507945 0.7348 1.0 1640717 TimTec1_004470 CCC(C(O)c1ccccc1)c2nc3ccccc3n2C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L05 compound treatment 8109960.0 232390.34482759 0.25695640871938 0.257 1.0 3084525 TimTec1_004471 Clc1cccc(c1)C(=O)OCC(=O)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L06 compound treatment 8953560.0 1075990.34482759 1.18973365708781 1.1897 1.0 3212798 TimTec1_004472 CCSc1nc(c(C#N)c(=O)n1CC)c2ccc(Cl)cc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L07 compound treatment 9017280.0 1139710.34482759 1.2601895203714 1.2602 1.0 1227993 TimTec1_004473 CC1(C)C2CCC3(C)OC(=O)N(N1c4ccccc4)C23C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L08 compound treatment 8857840.0 980270.34482759 1.0838950627139 1.0839 1.0 1742964 TimTec1_004474 CCOC(=O)N1CCN(CC1)C(=S)NC(=O)c2ccc(F)cc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L09 compound treatment 9184400.0 1306830.34482759 1.44497583349057 1.445 1.0 1439010 TimTec1_004475 COc1ccc(CCNC(=O)C2C(C3CC2C=C3)C(=O)O)cc1OC 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L10 compound treatment 9382640.0 1505070.34482759 1.66417185259507 1.6642 1.0 3084528 TimTec1_004476 CC1(C)CC(NC(=O)C(F)(F)F)C(NC(=O)C(F)(F)F)C(C)(C)N1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L11 compound treatment 9293840.0 1416270.34482759 1.56598477381944 1.566 1.0 3212799 TimTec1_004477 NC(=O)/C(=N/O)/C1=NC2(CCCCC2)Cc3ccccc13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L12 compound treatment 9238560.0 1360990.34482759 1.50486110586092 1.5049 1.0 1441377 TimTec1_004478 Clc1ccc(cc1)c2ccc(o2)C(=S)N3CCN(CC3)c4ccccc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L13 compound treatment 9112280.0 1234710.34482759 1.36523200329577 1.3652 1.0 1208093 TimTec1_004479 CN(C)CCOC(=O)C1(CC2c3ccccc3C1c4ccccc24)C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L14 compound treatment 9279040.0 1401470.34482759 1.54962026069017 1.5496 1.0 3084551 TimTec1_004480 CCOC(=O)c1c(O)c(Cl)c(C)[nH]c1=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L15 compound treatment 8611680.0 734110.34482759 0.811713403801654 0.8117 1.0 1150863 TimTec1_004481 CCOC(=O)c1c(C)c([nH]c1CN2CCOCC2)C(=O)OCc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L16 compound treatment 8529040.0 651470.34482759 0.720337500760916 0.7203 1.0 3212800 TimTec1_004482 CC(=O)N1N=C(CC1c2ccc(F)cc2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L17 compound treatment 9999640.0 2122070.34482759 2.3463951364302 2.3464 1.0 1417256 TimTec1_004483 OCCNC(=O)c1c2CCCCc2nc3ccccc13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L18 compound treatment 8802520.0 924950.34482759 1.02272716634152 1.0227 1.0 1332505 TimTec1_004484 NNc1nnc2c3ccccc3[nH]c2n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L19 compound treatment 9024800.0 1147230.34482759 1.26850446217762 1.2685 1.0 1647319 TimTec1_004485 COc1ccc(cc1)C2OC(=O)Cc3cc(OC)c(OC)cc23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L20 compound treatment 8209600.0 332030.34482759 0.367129387651848 0.3671 1.0 3084552 TimTec1_004486 O=c1nc(SCCOc2ccccc2)[nH]c3ccccc13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L21 compound treatment 8625960.0 748390.34482759 0.827502947550707 0.8275 1.0 3212801 TimTec1_004487 CC(=O)Nc1ccc2nc(C)sc2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L22 compound treatment 7897040.0 19470.3448275896 0.0215285617271971 0.0215 1.0 1262531 TimTec1_004488 Nc1nonc1c2noc(n2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L23 mock treatment 8433080.0 555510.34482759 0.614233535903834 0.6142 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 L24 mock treatment 8077680.0 200110.34482759 0.221264078732025 0.2213 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M01 compound treatment 7149840.0 -727729.65517241 -0.804658209231656 -0.8047 -1.0 3212802 TimTec1_004489 CCCc1c(C#N)c(N)[nH]c(=S)c1C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M02 compound treatment 3320320.0 -4557249.65517241 -5.03899809563737 -5.039 -1.0 3084553 TimTec1_004490 N#Cc1ccc(nc1SCc2ccncc2)c3cccs3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M03 compound treatment 8607920.0 730350.34482759 0.807555932898542 0.8076 1.0 1912735 TimTec1_004491 CCSc1nc(C)cc(COC)c1C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M04 compound treatment 7522960.0 -354609.65517241 -0.392095564718584 -0.3921 -1.0 1677912 TimTec1_004492 OC(C1CCCN1Cc2ccccc2)(c3ccccc3)c4ccccc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M05 compound treatment 9147440.0 1269870.34482759 1.40410877908125 1.4041 1.0 1303390 TimTec1_004493 CNC(=O)C(NS(=O)(=O)c1ccc(C)cc1)C(C)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M06 compound treatment 9493000.0 1615430.34482759 1.78619804644279 1.7862 1.0 1611737 TimTec1_004494 CC1CN(C)CC(C1)(OC(=O)C)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M07 compound treatment 9030480.0 1152910.34482759 1.27478489694615 1.2748 1.0 1011962 TimTec1_004495 OC(=O)CCC(=O)Nc1ccc2ccccc2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M08 compound treatment 8055840.0 178270.34482759 0.197115364762885 0.1971 1.0 1708192 TimTec1_004496 CCOC(=O)c1[nH]c(C)c(C(=O)C(C)C)c1C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M09 compound treatment 9365200.0 1487630.34482759 1.64488826415084 1.6449 1.0 1647225 TimTec1_004497 CC1CCN(CC1)c2nc(nc(n2)N3CCC(C)CC3)N4CCC(C)CC4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M10 compound treatment 8258640.0 381070.34482759 0.421353423047755 0.4214 1.0 3212803 TimTec1_004498 COc1cccc(OCCNC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M11 compound treatment 9559600.0 1682030.34482759 1.85983835552451 1.8598 1.0 3084554 TimTec1_004499 Oc1ccccc1/C=N/c2nc[nH]n2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M12 compound treatment 9044600.0 1167030.34482759 1.29039752703975 1.2904 1.0 3212804 TimTec1_004500 CCSc1nsc(SCC)c1C(=O)N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M13 compound treatment 8838720.0 961150.34482759 1.06275388088744 1.0628 1.0 3212805 TimTec1_004501 CSc1nnc2n(/N=C/c3cc4OCOc4cc3Br)cnn12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M14 compound treatment 9175520.0 1297950.34482759 1.435157125613 1.4352 1.0 1631850 TimTec1_004502 O=c1[nH]cc(COCc2ccccc2)c(=O)[nH]1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M15 compound treatment 8723640.0 846070.34482759 0.935508734203894 0.9355 1.0 1119024 TimTec1_004503 CC(C)(C)NC1=CC(=O)OC21CCCCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M16 compound treatment 9387680.0 1510110.34482759 1.66974463274179 1.6697 1.0 3212806 TimTec1_004504 COC(=O)c1cccc(NC(=O)COC(=O)CSc2nc(C)cc(C)n2)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M17 compound treatment 8513040.0 635470.34482759 0.702646135215759 0.7026 1.0 3212807 TimTec1_004505 NC(=O)CSc1nsc(SCc2ccc(Cl)cc2)c1C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M18 compound treatment 8993440.0 1115870.34482759 1.23382938570911 1.2338 1.0 1558723 TimTec1_004506 CC(=O)NC(Cc1ccc(F)cc1)C(=O)OCc2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M19 compound treatment 8559360.0 681790.34482759 0.75386263846899 0.7539 1.0 1121754 TimTec1_004507 CCOC(=O)c1cnn(CC2CCCCC2)c1N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M20 compound treatment 6696160.0 -1181409.65517241 -1.3062968792646 -1.3063 -1.0 1392807 TimTec1_004508 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC3CCCCC3)C(c4ccccc4)c5ccccc5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M21 compound treatment 6144600.0 -1732969.65517241 -1.91616247802004 -1.9162 -1.0 3084555 TimTec1_004509 CSc1nc2ccc(/N=C/c3ccc(Sc4nnnn4c5ccccc5)o3)cc2s1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M22 compound treatment 4506120.0 -3371449.65517241 -3.72784676667188 -3.7278 -1.0 1691433 TimTec1_004510 Clc1ccc(NC(=O)C2C3CCC=CCCC23)cc1Cl 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M23 mock treatment 8353320.0 475750.34482759 0.526042078661225 0.526 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 M24 mock treatment 7684120.0 -193449.65517241 -0.213899285264986 -0.2139 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N01 compound treatment 8185040.0 307470.34482759 0.339973141540031 0.34 1.0 3084556 TimTec1_004511 FC(F)(F)c1ccccc1/C=C\2/SC(=N)NC2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N02 compound treatment 8896640.0 1019070.34482759 1.12679662416091 1.1268 1.0 1558366 TimTec1_004512 O=C(N1CCCCCC1)c2cc3ccccc3c(=O)o2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N03 compound treatment 8481520.0 603950.34482759 0.667794145091799 0.6678 1.0 1395140 TimTec1_004513 Cc1ccc2[nH]c(SCC(=O)O)nc2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N04 compound treatment 1.316428E7 5286710.34482759 5.84557032760689 5.8456 1.0 3212808 TimTec1_004514 Clc1c(sc2ccccc12)C(=O)n3cccn3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N05 compound treatment 8832160.0 954590.34482759 1.05550042101392 1.0555 1.0 3084561 TimTec1_004515 Cc1nn(C(=O)Cc2ccc(Cl)cc2)c(C)c1Br 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N06 compound treatment 9771960.0 1894390.34482759 2.09464700472261 2.0946 1.0 1622238 TimTec1_004516 Nc1ccc(cc1F)c2nnn[nH]2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N07 compound treatment 9451320.0 1573750.34482759 1.74011203919765 1.7401 1.0 3084563 TimTec1_004517 CCNc1nnc(CSc2nc3ccccc3s2)s1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N08 compound treatment 8890280.0 1012710.34482759 1.11976430635671 1.1198 1.0 1261617 TimTec1_004518 CC(=C)CSC1=C(C#N)C(C)(C)C(C#N)C(=O)N1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N09 compound treatment 8841720.0 964150.34482759 1.06607101192716 1.0661 1.0 3212888 TimTec1_004519 COc1cccc(c1)C2C(=C(N)Oc3c2c(C)nn3c4ccccc4)C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N10 compound treatment 9118480.0 1240910.34482759 1.37208740744452 1.3721 1.0 1151574 TimTec1_004520 COc1cccc(c1)N2C(=O)NC(=O)C(CCc3ccncc3)(CCc4ccncc4)C2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N11 compound treatment 9442000.0 1564430.34482759 1.7298068187676 1.7298 1.0 3212889 TimTec1_004521 CCOC1CC(C)(C)NC(=S)N1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N12 compound treatment 9164640.0 1287070.34482759 1.4231269970423 1.4231 1.0 1367122 TimTec1_004522 OC1CCN(C2CCCCC12)S(=O)(=O)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N13 compound treatment 1.071492E7 2837350.34482759 3.13728763312646 3.1373 1.0 1402632 TimTec1_004523 CCCn1c(nc2ccccc12)c3nonc3N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N14 compound treatment 1.0259E7 2381430.34482759 2.6331721719172 2.6332 1.0 1157736 TimTec1_004524 CCOC(=O)c1cc(C(=O)NC(C)c2ccccc2)c(C)[nH]c1=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N15 compound treatment 8943680.0 1066110.34482759 1.17880923886367 1.1788 1.0 1611714 TimTec1_004525 COC(=O)C(C(=O)OC)c1ccc(C#N)c(C#N)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N16 compound treatment 3317120.0 -4560449.65517241 -5.0425363687464 -5.0425 -1.0 3212890 TimTec1_004526 COc1ccc(cc1)N(/N=C/2\Oc3ccc4c(C)cc(=O)oc4c3C2=O)C(=O)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N17 compound treatment 3728680.0 -4148889.65517241 -4.58747021851108 -4.5875 -1.0 1271644 TimTec1_004527 OC1(CSC2=C(C#N)C(CC(=O)N21)c3cccs3)c4ccccc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N18 compound treatment 7912640.0 35070.3448275896 0.0387776431337256 0.0388 1.0 1486726 TimTec1_004528 CCCS(=O)(=O)c1c(C(=O)c2ccc(C)cc2)n3cccc(N)c3c1S(=O)(=O)CCC 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N19 compound treatment 8485000.0 607430.34482759 0.67164201709787 0.6716 1.0 3084570 TimTec1_004529 Cc1nnnn1CC(=O)Nc2ccc(F)cc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N20 compound treatment 8243720.0 366150.34482759 0.404856224676896 0.4049 1.0 1252602 TimTec1_004530 COc1ccc(Br)cc1S(=O)(=O)NCc2ccccn2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N21 compound treatment 9231400.0 1353830.34482759 1.49694421977947 1.4969 1.0 3212891 TimTec1_004531 CCOC(=O)C1=C(OC(=C(C#N)C1c2ccc(F)cc2)N)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N22 compound treatment 7955960.0 78390.3448275896 0.0866770153472393 0.0867 1.0 1565486 TimTec1_004532 COc1cc(Oc2ccccc2CC=C)nc(N)n1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N23 mock treatment 1.094456E7 3066990.34482759 3.39120295711334 3.3912 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 N24 mock treatment 7150120.0 -727449.65517241 -0.804348610334615 -0.8043 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O01 compound treatment 7384160.0 -493409.65517241 -0.545568160822825 -0.5456 -1.0 1618653 TimTec1_004533 Cc1ccc(cc1C)C(=O)c2cccc(N)c2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O02 compound treatment 6690360.0 -1187209.65517241 -1.31270999927471 -1.3127 -1.0 3212892 TimTec1_004534 COC(=O)c1c(C)[nH]c(C)c1c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O03 compound treatment 8913680.0 1036110.34482759 1.1456379284665 1.1456 1.0 3084586 TimTec1_004535 CSc1nnc2n(/N=C/c3c[nH]c4ccccc34)cnn12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O04 compound treatment 8431560.0 553990.34482759 0.612552856177044 0.6126 1.0 3212893 TimTec1_004536 NC(=O)[C@@H]1[C@@H](c2ccc(Cl)cc2)C1(C#N)C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O05 compound treatment 8674240.0 796670.34482759 0.88088664308322 0.8809 1.0 1780136 TimTec1_004537 CCOC(=O)c1c(C)cc(C)[nH]c1=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O06 compound treatment 9045400.0 1167830.34482759 1.29128209531701 1.2913 1.0 1363495 TimTec1_004538 CN(Cn1nc(O)ccc1=O)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O07 compound treatment 6656280.0 -1221289.65517241 -1.3503926078859 -1.3504 -1.0 3084613 TimTec1_004539 NC1=NN(CC1)c2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O08 compound treatment 9122920.0 1245350.34482759 1.3769967613833 1.377 1.0 1493858 TimTec1_004540 COc1ccc(cc1OC)C2=C(N)C(=O)NC2=O 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O09 compound treatment 8605680.0 728110.34482759 0.80507914172222 0.8051 1.0 3212894 TimTec1_004541 Cc1ccccc1/C=N/N2C(=O)c3ccc4CCc5ccc(C2=O)c3c45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O10 compound treatment 3595400.0 -4282169.65517241 -4.73483929350225 -4.7348 -1.0 1029950 TimTec1_004542 CN(C)c1ccc(cc1)C(=NO)c2ccc(cc2)N(C)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O11 compound treatment 9826000.0 1948430.34482759 2.15439959185138 2.1544 1.0 1641866 TimTec1_004543 Cc1cc(C)c(cc1S(=O)(=O)N)S(=O)(=O)N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O12 compound treatment 8712120.0 834550.34482759 0.92277095101138 0.9228 1.0 3212895 TimTec1_004544 O=C(CSc1ccccn1)Nc2sc3CCCCc3c2C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O13 compound treatment 9352440.0 1474870.34482759 1.63077940012858 1.6308 1.0 3084617 TimTec1_004545 O=C(CSc1ncn[nH]1)Nc2ccccc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O14 compound treatment 9553600.0 1676030.34482759 1.85320409344507 1.8532 1.0 1421449 TimTec1_004546 NC(=O)Cc1ccc(NC(=O)CCC(=O)O)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O15 compound treatment 8810160.0 932590.34482759 1.03117479338933 1.0312 1.0 1919218 TimTec1_004547 OC(=O)CCCC(=O)Nc1cccc(c1)C(F)(F)F 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O16 compound treatment 7775120.0 -102449.65517241 -0.113279643726903 -0.1133 -1.0 3084620 TimTec1_004548 FC(F)(F)c1cccc(c1)N2CCN(CC2)C(=S)Nc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O17 compound treatment 8725040.0 847470.34482759 0.937056728689095 0.9371 1.0 1239543 TimTec1_004549 O=C(CSc1nc2ccccc2o1)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O18 compound treatment 8211160.0 333590.34482759 0.368854295792501 0.3689 1.0 1529100 TimTec1_004550 CCn1cc(c(C#N)c1NC(=O)C)C(C)(C)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O19 compound treatment 7918520.0 40950.3448275896 0.0452792199715709 0.0453 1.0 3084622 TimTec1_004551 Clc1ccc(OCCNC(=O)c2cccs2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O20 compound treatment 8472560.0 594990.34482759 0.65788698038651 0.6579 1.0 1322941 TimTec1_004552 Cc1cc(C)n(NC2=CC(=O)CC(C)(C)C2)c(=O)c1C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O21 compound treatment 8301560.0 423990.34482759 0.46881051112264 0.4688 1.0 3212896 TimTec1_004553 CCN/C(=N/CC)/SC1CC(=O)N(C1=O)c2ccc(OCC)cc2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O22 compound treatment 8252640.0 375070.34482759 0.414719160968321 0.4147 1.0 3084625 TimTec1_004554 Nc1nc(nc2c3ccccc3oc(=O)c12)c4cccnc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O23 mock treatment 9028880.0 1151310.34482759 1.27301576039163 1.273 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 O24 mock treatment 7812840.0 -64729.6551724104 -0.071572249454194 -0.0716 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P01 compound treatment 8161000.0 283430.34482759 0.313391864808432 0.3134 1.0 1465751 TimTec1_004555 O=C(Cc1ccccc1)Nc2ccc3oc(nc3c2)c4ccncc4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P02 compound treatment 7226840.0 -650729.65517241 -0.719518512545586 -0.7195 -1.0 1350858 TimTec1_004556 Cc1cccc(C)c1N2CCc3cn[nH]c23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P03 compound treatment 8399520.0 521950.34482759 0.577125896672867 0.5771 1.0 1593678 TimTec1_004557 COc1ccc(CCC(O)C2(O)CCCCC2)cc1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P04 compound treatment 8108880.0 231310.34482759 0.255762241545082 0.2558 1.0 1664967 TimTec1_004558 Clc1ccc(NC(=O)CC2SCCNC2=O)cc1Cl 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P05 compound treatment 8758000.0 880430.34482759 0.973500941712119 0.9735 1.0 1438867 TimTec1_004559 O=C1N(CC2CCCO2)C(=O)c3cc(ccc13)c4nc5ccccc5c(=O)o4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P06 compound treatment 9958640.0 2081070.34482759 2.30106101222073 2.3011 1.0 1740022 TimTec1_004560 CC1CN(Cn2nc(c3ccccc3)n(CC=C)c2=S)CC(C)O1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P07 compound treatment 9248480.0 1370910.34482759 1.51582975249892 1.5158 1.0 1430817 TimTec1_004561 O=C(CSCc1ccccc1)Nc2nnc(Cc3ccccc3)s2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P08 compound treatment 8504640.0 627070.34482759 0.693358168304551 0.6934 1.0 1573254 TimTec1_004562 CC(CN1CCNCC1)(NS(=O)(=O)c2ccccc2)c3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P09 compound treatment 9287600.0 1410030.34482759 1.55908514125683 1.5591 1.0 1431707 TimTec1_004563 COc1cc2C(CC(=O)Nc3ccccc3)C(=O)N(N=C(C)c2cc1OC)C(=O)C 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P10 compound treatment 1.009248E7 2214910.34482759 2.44904928500598 2.449 1.0 1386480 TimTec1_004564 CC(C)CNC(=O)c1cccc(NC(=O)CC(C)C)c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P11 compound treatment 9035680.0 1158110.34482759 1.28053459074833 1.2805 1.0 3212897 TimTec1_004565 C=CC/N=C(\SCc1ccccc1)/N2CCCC2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P12 compound treatment 8574960.0 697390.34482759 0.771111719875518 0.7711 1.0 1213970 TimTec1_004566 CC(=O)Oc1coc2ccc3c(C)cc(=O)oc3c12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P13 compound treatment 9737040.0 1859470.34482759 2.0560355994203 2.056 1.0 1578888 TimTec1_004567 Clc1ccc(cc1)C(NC(=O)c2ccccc2Cl)C#N 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P14 compound treatment 9514040.0 1636470.34482759 1.80946219213467 1.8095 1.0 1291706 TimTec1_004568 COC(=O)C1=C(C)NC(=C(C#N)C1c2cccnc2)S 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P15 compound treatment 8825520.0 947950.34482759 1.04815850431268 1.0482 1.0 3212898 TimTec1_004569 CCSc1cccc2cccnc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P16 compound treatment 8590120.0 712550.34482759 0.787874288729555 0.7879 1.0 1230586 TimTec1_004570 CC(=O)Nc1cc2c(C)cc(=O)oc2c3C(=O)COc31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P17 compound treatment 8591520.0 713950.34482759 0.789422283214756 0.7894 1.0 3085776 TimTec1_004571 CCc1nnc(NC(=O)COC(=O)CSc2nc(cc(n2)c3ccccc3)c4ccccc4)s1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P18 compound treatment 1.31294E7 5251830.34482759 5.80700315071845 5.807 1.0 1673944 TimTec1_004572 Cc1nn2cc(nc2s1)c3ccc(N)cc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P19 compound treatment 8696000.0 818430.34482759 0.904946900224634 0.9049 1.0 3212899 TimTec1_004573 O=C(CSC1=NC(=O)C(Cc2ccccc2)C(=O)N1)NCc3ccccc3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P20 compound treatment 1.3997E7 6119430.34482759 6.76631744740461 6.7663 1.0 3085777 TimTec1_004574 CCOC(=O)C1NCCc2ccccc12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P21 compound treatment 8714520.0 836950.34482759 0.925424655843154 0.9254 1.0 1311348 TimTec1_004575 CCC(=O)Oc1ccc2c3CCCc3c(=O)oc2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P22 compound treatment 2911360.0 -4966209.65517241 -5.49118939897159 -5.4912 -1.0 1265079 TimTec1_004576 COc1ccc2nc(C)c3CC(C)Oc3c2c1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P23 mock treatment 8263600.0 386030.34482759 0.426837746366754 0.4268 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2075 P24 mock treatment 7814320.0 -63249.6551724104 -0.069935798141267 -0.0699 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A01 compound treatment 4526280.0 -500184.24242424 -0.55305889204093 -1.5465 -0.9617 3000745 BCB02_000001 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5cccc(O)c5 4288440.0 -1060000.0 -1.17 4098840.0 -956000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A02 compound treatment 4288320.0 -738144.24242424 -0.816173726111284 -1.3412 -0.9261 3000746 BCB02_000002 CC(C)OC(=O)C1=CCC(O1)c2cccc(Cl)c2 4314000.0 -1040000.0 -1.14 4687360.0 -368000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A03 compound treatment 4727160.0 -299304.24242424 -0.330943797621479 -0.4544 -0.9208 3000747 BCB02_000003 OC(C1CCCCC1)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 5256720.0 -96400.0 -0.11 4705600.0 -349000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A04 compound treatment 4767000.0 -259464.24242424 -0.286892297414037 -0.43 -0.6337 3000748 BCB02_000004 CCOC(=O)C1=CCC(O1)c2cccc(Cl)c2 4806520.0 -547000.0 -0.6 5195080.0 140000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A05 compound treatment 4516280.0 -510184.24242424 -0.564115995506654 -0.6521 -0.8735 3000749 BCB02_000005 CC(=C)[C@H]1CCC(=CC1)C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 4913120.0 -440000.0 -0.48 4971680.0 -83200.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A06 compound treatment 5024680.0 -1784.24242424034 -0.00197285530927585 -0.0177 -0.0903 3000750 BCB02_000006 COC(=O)C1=CCC(O1)c2cccc(Cl)c2 5213840.0 -139000.0 -0.15 5178280.0 123000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A07 compound treatment 4767520.0 -258944.24242424 -0.286317328033819 -0.5918 -0.9506 3093754 BCB02_000007 CCCCC(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O 4899080.0 -454000.0 -0.5 4814360.0 -241000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A08 compound treatment 4240920.0 -785544.24242424 -0.868584396538813 -0.7854 -0.8394 2065163 BCB02_000008 CCOC(=O)/C=C/c1ccccc1O 5120840.0 -232000.0 -0.25 4818360.0 -237000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A09 compound treatment 4639840.0 -386624.24242424 -0.427494425084175 -0.5813 -0.8368 3093755 BCB02_000009 CCCCCCCCCCC(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O 4854040.0 -499000.0 -0.55 5022280.0 -32600.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A10 compound treatment 4592680.0 -433784.24242424 -0.479639725028527 -0.9263 -0.8946 3000752 BCB02_000010 CCOC(=O)/C=C/c1cc(F)ccc1O 4544120.0 -809000.0 -0.89 4817000.0 -238000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A11 compound treatment 5366640.0 340175.75757576 0.376135854804602 0.2346 0.6071 3093756 BCB02_000011 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(F)cc5 5311320.0 -41800.0 -0.05 5130680.0 75800.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A12 compound treatment 4469200.0 -557264.24242424 -0.61617283862328 -1.0149 -0.9915 3000753 BCB02_000012 CCOC(=O)/C=C/c1cc(ccc1O)[N+](=O)[O-] 4749160.0 -604000.0 -0.66 4576440.0 -478000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A13 compound treatment 4780880.0 -245584.24242424 -0.271545037803612 -0.3549 -0.9686 3093757 BCB02_000013 COc1ccc(C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O)c6ccccc16 5170520.0 -183000.0 -0.2 4912320.0 -143000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A14 compound treatment 5087120.0 60655.7575757597 0.0670676987307011 0.1329 0.4274 3000754 BCB02_000014 CCOC(=O)/C=C/c1cccc(OC)c1O 5246240.0 -107000.0 -0.12 5334200.0 279000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A15 compound treatment 4915720.0 -110744.24242424 -0.122451054671798 0.0825 0.2198 3093824 BCB02_000015 COc1cc(OC)c(cc1Br)C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 5279960.0 -73200.0 -0.08 5399160.0 344000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A16 compound treatment 4914040.0 -112424.24242424 -0.12430864805404 -0.6896 -0.7763 3000755 BCB02_000016 CCOC(=O)/C=C/c1cccc(C)c1O 4575000.0 -778000.0 -0.85 4837720.0 -217000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A17 mock treatment 4393960.0 -632504.24242424 -0.699366485099382 -0.6924 -0.8745 5198200.0 -155000.0 -0.17 4725840.0 -329000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A18 mock treatment 4985560.0 -40904.2424242403 -0.0452282440671858 -0.1305 -0.4243 5092400.0 -261000.0 -0.29 5159320.0 104000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A19 mock treatment 5042120.0 15655.7575757597 0.0173107331349458 -0.194 -0.5743 5045480.0 -308000.0 -0.34 5038560.0 -16300.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A20 mock treatment 4719760.0 -306704.24242424 -0.339126054186114 -0.2463 -0.4539 5042720.0 -310000.0 -0.34 5306560.0 252000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A21 mock treatment 4735920.0 -290544.24242424 -0.321257774985505 -0.5394 -0.9988 5057920.0 -295000.0 -0.32 4766200.0 -289000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A22 mock treatment 5167840.0 141375.75757576 0.15632063790602 -0.396 -0.6103 4836240.0 -517000.0 -0.57 4779680.0 -275000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A23 mock treatment 5052520.0 26055.7575757597 0.0288101207392981 -0.7838 -0.7595 4512800.0 -840000.0 -0.92 4590440.0 -464000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 A24 mock treatment 4729520.0 -296944.24242424 -0.328334321203568 -1.2947 -0.8547 4094640.0 -1260000.0 -1.38 4520840.0 -534000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B01 compound treatment 4934600.0 -91864.2424242403 -0.101575243328512 -0.5456 -0.8696 3093825 BCB02_000017 COc1ccc(cc1OCc2ccccc2)C(O)C3C=CC4C(N3n5cnnc5)C(=O)N(Cc6ccccc6)C4=O 4860760.0 -492000.0 -0.54 4751800.0 -303000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B02 compound treatment 5099200.0 72735.7575757597 0.080424679717295 -0.0584 -0.201 3000756 BCB02_000018 CCOC(=O)C1=CCC(N(CCN2CC(=CCC2c3cc4ccccc4[nH]3)C(=O)OCC)C1)c5cc6ccccc6[nH]5 5110160.0 -243000.0 -0.27 5139120.0 84200.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B03 compound treatment 5368320.0 341855.75757576 0.377993448186843 0.9236 0.9768 3093826 BCB02_000019 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5cc(cc(c5)C(F)(F)F)C(F)(F)F 5956040.0 603000.0 0.66 5614320.0 559000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B04 compound treatment 4989000.0 -37464.2424242403 -0.041424600474977 -0.1047 -0.6311 3000757 BCB02_000020 CC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 5207520.0 -146000.0 -0.16 5074360.0 19500.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B05 compound treatment 5284640.0 258175.75757576 0.28546760638567 0.3461 0.7998 3093827 BCB02_000021 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(s5)c6ccccc6 5343080.0 -10100.0 -0.01 5378720.0 324000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B06 compound treatment 5809840.0 783375.75757576 0.866186680405463 0.7051 0.7816 3093828 BCB02_000022 Cc1ccc(cc1)[C@@H]2C[C@@H](Sc3ccccc3)[C@@H](CN2S(=O)(=O)c4ccc(C)cc4)C(=O)O 5531000.0 178000.0 0.19 5214720.0 160000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B07 compound treatment 5213920.0 187455.75757576 0.207271770676074 0.6241 0.9383 3000758 BCB02_000023 CC(C(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccccc5 5665920.0 313000.0 0.34 5584120.0 529000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B08 compound treatment 5322800.0 296335.75757576 0.32766151321087 0.7911 0.9791 3093829 BCB02_000024 Cc1ccc(cc1)C2CC=C(CN2S(=O)(=O)c3ccc(C)cc3)C(=O)O 5800120.0 447000.0 0.49 5606080.0 551000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B09 compound treatment 5662160.0 635695.75757576 0.70289537642366 1.4481 0.9936 3000759 BCB02_000025 CC(CC(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(C)o5 6163920.0 811000.0 0.89 5969000.0 914000.0 0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B10 compound treatment 5801360.0 774895.75757576 0.85681025666653 1.1956 0.9285 3093830 BCB02_000026 Cc1ccc(cc1)S(=O)(=O)N2CC(=CCC2c3ccccc3)C(=O)O 5628200.0 275000.0 0.3 5964560.0 910000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B11 compound treatment 5833720.0 807255.75757576 0.89259104348161 1.2342 0.9669 3093831 BCB02_000027 OC(Cc1ccccc1)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 6076360.0 723000.0 0.79 5506360.0 451000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B12 compound treatment 5355920.0 329455.75757576 0.364282639889346 0.7937 0.9873 3000760 BCB02_000028 Cc1ccc(cc1)[C@@H]2CC=C([C@@H](N2S(=O)(=O)c3ccc(C)cc3)c4ccccc4)C(=O)O 5849920.0 497000.0 0.54 5519760.0 465000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B13 compound treatment 5311840.0 285375.75757576 0.315542927812437 1.1267 0.9372 3093832 BCB02_000029 OC(C1CCCCC1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 6156440.0 803000.0 0.88 5808440.0 754000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B14 compound treatment 5289840.0 263375.75757576 0.291217300187846 0.9072 0.9519 3093833 BCB02_000030 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccccc4 5978800.0 626000.0 0.69 5647760.0 593000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B15 compound treatment 5537440.0 510975.75757576 0.564991181999157 1.1725 0.9757 3000761 BCB02_000031 CC(=C)[C@H]1CCC(=CC1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 6167640.0 814000.0 0.89 5626800.0 572000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B16 compound treatment 4911640.0 -114824.24242424 -0.126962352885813 0.6263 0.7164 3093834 BCB02_000032 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccc(C#N)cc4 5830160.0 477000.0 0.52 5741880.0 687000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B17 mock treatment 4936000.0 -90464.2424242403 -0.100027248843311 -0.3247 -0.263 4376160.0 -977000.0 -1.07 5660320.0 605000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B18 mock treatment 5387640.0 361175.75757576 0.399355772082621 0.7671 0.9638 5644880.0 292000.0 0.32 5662640.0 608000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B19 mock treatment 5059640.0 33175.7575757597 0.0366827784068932 0.2977 0.8524 5522120.0 169000.0 0.19 5347720.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B20 mock treatment 5274440.0 247975.75757576 0.274189360850632 0.829 0.942 5782560.0 429000.0 0.47 5743920.0 689000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B21 mock treatment 4498080.0 -528384.24242424 -0.58423992381427 0.2218 0.2462 5816360.0 463000.0 0.51 5514400.0 460000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B22 mock treatment 4940400.0 -86064.2424242403 -0.0951621233183927 0.0335 0.096 5218160.0 -135000.0 -0.15 5354800.0 300000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B23 mock treatment 4926520.0 -99944.2424242403 -0.110509382928817 0.3045 0.6535 5668640.0 315000.0 0.35 5346320.0 291000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 B24 mock treatment 4792200.0 -234264.24242424 -0.259028396680414 -0.5073 -0.8466 4866080.0 -487000.0 -0.53 4968920.0 -86000.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C01 compound treatment 4627520.0 -398944.24242424 -0.441116776553947 -0.8188 -0.994 3093835 BCB02_000033 CC(=O)n1cc(C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5)c6ccccc16 4854320.0 -499000.0 -0.55 4625720.0 -429000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C02 compound treatment 5338960.0 312495.75757576 0.345529792411479 0.6609 0.9937 3000762 BCB02_000034 CCOC(=O)/C=C/c1ccccc1OC(=O)C#CC 5679080.0 326000.0 0.36 5495640.0 441000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C03 compound treatment 6076400.0 1049935.75757576 1.16092483038779 2.1058 0.9975 3000763 BCB02_000035 Cc1ccccc1C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 6403480.0 1050000.0 1.15 6386360.0 1330000.0 1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C04 compound treatment 5682320.0 655855.75757576 0.725186497010558 2.1125 0.9546 3093836 BCB02_000036 CCOC(=O)[C@H]1CC=C2[C@@H]1c3ccccc3OC2=O 6860360.0 1510000.0 1.65 6333520.0 1280000.0 1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C05 compound treatment 6314160.0 1287695.75757576 1.42381852238883 1.5461 0.9125 3093837 BCB02_000037 OC(/C=C/c1ccc(cc1)[N+](=O)[O-])C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 5771720.0 419000.0 0.46 5847760.0 793000.0 0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C06 compound treatment 5638360.0 611895.75757576 0.676579470175238 1.5054 0.9852 3000764 BCB02_000038 CCOC(=O)[C@H]1CC=C2[C@@H]1c3cc(Br)ccc3OC2=O 6308920.0 956000.0 1.05 5935960.0 881000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C07 compound treatment 5864560.0 838095.75757576 0.926691150569901 1.1111 0.9511 3093838 BCB02_000039 OC(C(c1ccccc1)c2ccccc2)C3C=CC4C(N3n5cnnc5)C(=O)N(Cc6ccccc6)C4=O 5750640.0 397000.0 0.44 5615360.0 560000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C08 compound treatment 3513400.0 -1513064.24242424 -1.67301078787712 -2.9241 -0.9969 3000765 BCB02_000040 CCOC(=O)/C=C/c1cc(Br)ccc1OC(=O)C#CC 3954200.0 -1400000.0 -1.53 3201800.0 -1850000.0 -1.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C09 compound treatment 5430040.0 403575.75757576 0.446237890777288 0.9414 0.9867 3093839 BCB02_000041 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5cccc6ccccc56 5829960.0 477000.0 0.52 5714640.0 660000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C10 compound treatment 5235240.0 208775.75757576 0.230845515264996 -0.0665 -0.1644 3000766 BCB02_000042 O=c1oc2ccccc2cc1C#C 5340080.0 -13100.0 -0.01 4724400.0 -330000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C11 compound treatment 6125200.0 1098735.75757576 1.21488349530052 1.3454 0.9278 3093840 BCB02_000043 OC(C1CCC=CC1)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 5818880.0 466000.0 0.51 5658080.0 603000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C12 compound treatment 5739960.0 713495.75757576 0.788919641386988 1.2057 0.981 3000767 BCB02_000044 Cn1c2C3NC(C(=O)c2c4ccccc14)C(C)(C=C3)C(=O)OCc5ccccc5 6081960.0 729000.0 0.8 5554400.0 500000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C13 compound treatment 5814760.0 788295.75757576 0.871626775310599 1.33 0.9884 3093841 BCB02_000045 CC(=O)n1cc(C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O)c6ccccc16 6110360.0 757000.0 0.83 5655480.0 601000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C14 compound treatment 5085680.0 59215.7575757597 0.0654754758316369 0.0614 0.2419 3000768 BCB02_000046 [O-][N+](=O)c1ccccc1S(=O)(=O)N2C3CC=C(C2C(=O)c4c3[nH]c5ccccc45)C(=O)OCc6ccccc6 5529120.0 176000.0 0.19 4903640.0 -151000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C15 compound treatment 5279880.0 253415.75757576 0.280204425135985 0.696 0.9368 3093842 BCB02_000047 CCCCC(CC)C(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O 5638000.0 285000.0 0.31 5666040.0 611000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C16 compound treatment 5416680.0 390215.75757576 0.431465600547082 1.3384 0.9541 3093843 BCB02_000048 CCOC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3 6188640.0 835000.0 0.91 6023200.0 968000.0 0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C17 mock treatment 6097480.0 1071015.75757576 1.18423320449353 1.5368 0.9615 6186920.0 834000.0 0.91 5617440.0 563000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C18 mock treatment 5503440.0 476975.75757576 0.527397030215698 1.2766 0.9773 6188120.0 835000.0 0.91 5821560.0 767000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C19 mock treatment 5460560.0 434095.75757576 0.479984170554676 1.1566 0.97 6162680.0 810000.0 0.89 5689480.0 635000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C20 mock treatment 5389840.0 363375.75757576 0.40178833484508 1.0695 0.9666 6082200.0 729000.0 0.8 5704840.0 650000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C21 mock treatment 5408720.0 382255.75757576 0.422664146188366 1.0266 0.9693 5871160.0 518000.0 0.57 5840200.0 785000.0 0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C22 mock treatment 5302440.0 275975.75757576 0.305149250554657 0.7448 0.94 5946840.0 594000.0 0.65 5388480.0 334000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C23 mock treatment 5210560.0 184095.75757576 0.203556583911591 0.4921 0.9558 5575240.0 222000.0 0.24 5459000.0 404000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 C24 mock treatment 4991520.0 -34944.2424242403 -0.0386382104016147 -0.3746 -0.8584 5040480.0 -313000.0 -0.34 4788120.0 -267000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D01 compound treatment 5037840.0 11375.7575757597 0.0125782928516161 -0.0178 -0.1643 3000769 BCB02_000049 CCCCC(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 5400040.0 46900.0 0.05 4960440.0 -94500.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D02 compound treatment 5473040.0 446575.75757576 0.493783435679899 0.5247 0.9119 3093844 BCB02_000050 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccc(F)cc4 5520960.0 168000.0 0.18 5285360.0 230000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D03 compound treatment 5621600.0 595135.75757576 0.658047764766686 0.8931 0.9557 3093845 BCB02_000051 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5c(F)cccc5Cl 5896440.0 543000.0 0.59 5347800.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D04 compound treatment 5788600.0 762135.75757576 0.842701392644266 1.146 0.9477 3000770 BCB02_000052 Cc1ccc(cc1)S(=O)(=O)N2C[C@H]([C@@H](C[C@H]2c3ccccc3)Sc4ccccc4)C(=O)O 6078520.0 725000.0 0.79 5401480.0 347000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D05 compound treatment 5840160.0 813695.75757576 0.899711818113536 1.1673 0.9686 3093846 BCB02_000053 Cc1cc(C)c(C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5)c(C)c1 5791000.0 438000.0 0.48 5695320.0 640000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D06 compound treatment 4748320.0 -278144.24242424 -0.307546966688008 0.0415 0.0677 3000771 BCB02_000054 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 5821040.0 468000.0 0.51 4922360.0 -133000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D07 compound treatment 6142400.0 1115935.75757576 1.23390171326156 1.4291 0.9408 3092586 BCB02_000055 Cc1ccccc1C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 5841840.0 489000.0 0.54 5758680.0 704000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D08 compound treatment 4283880.0 -742584.24242424 -0.821083080050066 -1.5869 -0.9514 3092495 BCB02_000056 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(F)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 4150120.0 -1200000.0 -1.32 4447120.0 -608000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D09 compound treatment 5828120.0 801655.75757576 0.886399065540805 1.2873 0.9902 3000772 BCB02_000057 OC(C1CCC=CC1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 5997200.0 644000.0 0.71 5690560.0 636000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D10 compound treatment 5017920.0 -8544.24242424034 -0.00944745725210488 -1.1053 -0.6335 3092496 BCB02_000058 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 3767280.0 -1590000.0 -1.74 4887200.0 -168000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D11 compound treatment 5824280.0 797815.75757576 0.882153137809968 1.0487 0.6509 3092497 BCB02_000059 CC(=O)n1cc(C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5)c6ccccc16 6538440.0 1190000.0 1.3 4692400.0 -362000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D12 compound treatment 4398440.0 -628024.24242424 -0.694412902746738 -1.1464 -0.9572 3000773 BCB02_000060 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc(Cl)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 4986040.0 -367000.0 -0.4 4168840.0 -886000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D13 compound treatment 5896920.0 870455.75757576 0.962471937384982 1.5953 0.9992 3092498 BCB02_000061 CCCCC(CC)C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 6201040.0 848000.0 0.93 5923960.0 869000.0 0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D14 compound treatment 4732760.0 -293704.24242424 -0.324751819680673 -0.404 -0.7429 3000774 BCB02_000062 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2Cl)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 5405600.0 52400.0 0.06 4623960.0 -431000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D15 compound treatment 5490160.0 463695.75757576 0.512713196813217 0.8353 0.9966 3092499 BCB02_000063 CC(=CCC/C(=C/C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)/C)C 5817480.0 464000.0 0.51 5478920.0 424000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D16 compound treatment 4043560.0 -982904.24242424 -1.08680739053833 -1.7511 -0.9939 3000775 BCB02_000064 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 4574720.0 -778000.0 -0.85 3965160.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D17 mock treatment 5019520.0 -6944.24242424034 -0.00767832069758913 0.3528 0.7282 5770000.0 417000.0 0.46 5216640.0 162000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D18 mock treatment 5601800.0 575335.75757576 0.636154699904553 1.2559 0.9957 6028880.0 676000.0 0.74 5851160.0 796000.0 0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D19 mock treatment 5542080.0 515615.75757576 0.570121678007253 0.8596 0.9677 5904960.0 552000.0 0.6 5368160.0 313000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D20 mock treatment 5478560.0 452095.75757576 0.499886956792978 1.2129 0.9783 6035800.0 683000.0 0.75 5905280.0 850000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D21 mock treatment 5433760.0 407295.75757576 0.450351133266537 0.7642 0.9565 5902200.0 549000.0 0.6 5325960.0 271000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D22 mock treatment 5700960.0 674495.75757576 0.745796937870667 0.9624 0.8317 6160400.0 807000.0 0.88 5091920.0 37000.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D23 mock treatment 5233920.0 207455.75757576 0.229385977607521 0.441 0.9881 5557680.0 205000.0 0.22 5364280.0 309000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 D24 mock treatment 5009480.0 -16984.2424242403 -0.0187796525771754 -0.2253 -0.8555 5180920.0 -172000.0 -0.19 4872800.0 -182000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E01 compound treatment 5265920.0 239455.75757576 0.264768708697836 0.1864 0.6941 3092500 BCB02_000065 CCCCC(CC)C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4 5368320.0 15200.0 0.02 5096200.0 41300.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E02 compound treatment 5013400.0 -13064.2424242403 -0.0144452680186119 0.7143 0.7184 3000776 BCB02_000066 CCOC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(CC)C2=O 5632240.0 279000.0 0.31 5997520.0 943000.0 0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E03 compound treatment 5361760.0 335295.75757576 0.370739988313329 0.6744 0.9987 3000847 BCB02_000067 CC1(C)[C@H]2C[C@@H]1C=C(C2)C(O)C3C=CC4C(N3n5cnnc5)C(=O)N(Cc6ccccc6)C4=O 5700600.0 347000.0 0.38 5470240.0 415000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E04 compound treatment 5808480.0 782015.75757576 0.864682914334125 1.5274 0.9976 3000848 BCB02_000068 CCOC(=O)[C@H]1[C@H](C[C@@H]2[C@H]1C(=O)N(CC)C2=O)Sc3ccccc3 6099760.0 747000.0 0.82 6014640.0 960000.0 0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E05 compound treatment 5736160.0 709695.75757576 0.784717942070013 1.0189 0.9704 3000849 BCB02_000069 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(Br)cc5 5852640.0 499000.0 0.55 5486480.0 432000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E06 compound treatment 5676880.0 650415.75757576 0.719171432725205 1.3138 0.9772 3000850 BCB02_000070 OC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3 5881880.0 529000.0 0.58 6028720.0 974000.0 0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E07 compound treatment 5065720.0 39255.7575757597 0.043405497314053 0.1791 0.9002 3000851 BCB02_000071 OC(/C=C/c1ccc(cc1)[N+](=O)[O-])C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 5504600.0 151000.0 0.17 5155440.0 101000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E08 compound treatment 5883760.0 857295.75757576 0.94792078922409 1.5734 0.9948 3092501 BCB02_000072 OC(=O)[C@H]1[C@H](C[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3)Sc4ccccc4 6065400.0 712000.0 0.78 6048720.0 994000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E09 compound treatment 6009160.0 982695.75757576 1.08657686668426 1.5807 0.9905 3000852 BCB02_000073 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(cc5)[N+](=O)[O-] 6140320.0 787000.0 0.86 5841400.0 787000.0 0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E10 compound treatment 5061280.0 34815.7575757597 0.0384961433752718 -0.6401 -0.7564 3092502 BCB02_000074 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 4983160.0 -370000.0 -0.41 4315640.0 -739000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E11 compound treatment 5697600.0 671135.75757576 0.742081751106183 1.7257 0.9646 3092503 BCB02_000075 COc1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 6607840.0 1250000.0 1.37 5924720.0 870000.0 0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E12 compound treatment 5200960.0 174495.75757576 0.192941764584496 -0.0149 -0.0507 3000853 BCB02_000076 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 5151640.0 -202000.0 -0.22 5056880.0 1980.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E13 compound treatment 5991160.0 964695.75757576 1.06667408044596 1.6651 0.994 3092504 BCB02_000077 CN(C)c1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 6099440.0 746000.0 0.82 6051400.0 997000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E14 compound treatment 5527680.0 501215.75757576 0.554199449016611 0.7456 0.9733 3000854 BCB02_000078 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(OC)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4Cl 5632040.0 279000.0 0.31 5485160.0 430000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E15 compound treatment 5623400.0 596935.75757576 0.660038043390516 0.9891 0.954 3092505 BCB02_000079 OC(C(c1ccccc1)c2ccccc2)C3C=CC4C(N3Nc5ccccc5F)C(=O)N(C4=O)c6ccccc6 6021880.0 669000.0 0.73 5374600.0 320000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E16 compound treatment 5107880.0 81415.7575757597 0.0900222455255429 -0.0843 -0.097 3000855 BCB02_000080 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)C(C)(C)C 5792800.0 440000.0 0.48 4339960.0 -715000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E17 mock treatment 5590760.0 564295.75757576 0.623947657678395 1.1125 0.9767 6105240.0 752000.0 0.82 5532600.0 478000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E18 mock treatment 5419040.0 392575.75757576 0.434075076964992 1.1413 0.9714 6086280.0 733000.0 0.8 5792200.0 737000.0 0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E19 mock treatment 5367960.0 341495.75757576 0.377595392462077 0.9853 0.9684 5896920.0 544000.0 0.6 5785720.0 731000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E20 mock treatment 5683480.0 657015.75757576 0.726469121012582 1.0159 0.9813 5759360.0 406000.0 0.44 5641040.0 586000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E21 mock treatment 5478600.0 452135.75757576 0.499931185206841 0.4688 0.857 5511400.0 158000.0 0.17 5193200.0 138000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E22 mock treatment 5260280.0 233815.75757576 0.258532502343168 0.1593 0.5513 5444240.0 91100.0 0.1 4972920.0 -82000.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E23 mock treatment 5787720.0 761255.75757576 0.841728367539283 0.9013 0.8946 5822880.0 470000.0 0.51 5259120.0 204000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 E24 mock treatment 4855280.0 -171184.24242424 -0.18928018801863 -0.3554 -0.7556 4960040.0 -393000.0 -0.43 5059160.0 4260.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F01 compound treatment 5356720.0 330255.75757576 0.365167208166604 -0.2106 -0.3326 3092506 BCB02_000081 OC(COCc1ccccc1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 5042560.0 -311000.0 -0.34 4666520.0 -388000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F02 compound treatment 4627280.0 -399184.24242424 -0.441382147037124 -1.0119 -0.9393 3092507 BCB02_000082 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 4544320.0 -809000.0 -0.89 4630840.0 -424000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F03 compound treatment 5275000.0 248535.75757576 0.274808558644712 0.2009 0.4576 3000856 BCB02_000083 COc1ccc(NN2C3C(C=CC2C(O)c4ccccc4)C(=O)N(C5CCCCC5)C3=O)cc1 5168000.0 -185000.0 -0.2 5329880.0 275000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F04 compound treatment 5051200.0 24735.7575757597 0.0273505830818226 -0.4722 -0.7517 3092508 BCB02_000084 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 5090960.0 -262000.0 -0.29 4498800.0 -556000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F05 compound treatment 5770640.0 744175.75757576 0.822842834819827 1.6349 0.9896 3092509 BCB02_000085 CCCCC(O)C1C=CC2C(N1Nc3ccc(OC)cc3)C(=O)N(C4CCCCC4)C2=O 6150400.0 797000.0 0.87 6186600.0 1130000.0 1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F06 compound treatment 4489480.0 -536984.24242424 -0.593749032794793 -1.0474 -0.7707 3000857 BCB02_000086 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(F)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 5355080.0 1920.0 0.0 3836680.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F07 compound treatment 5729280.0 702815.75757576 0.777110654885595 0.9131 0.8557 3092510 BCB02_000087 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(F)cc4)C(=O)N(C5CCCCC5)C3=O)cc1 6017200.0 664000.0 0.73 5131880.0 77000.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F08 compound treatment 4882120.0 -144344.24242424 -0.159602922316629 -0.8549 -0.7341 3000858 BCB02_000088 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(Cl)c(Cl)c2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 5186920.0 -166000.0 -0.18 3919920.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F09 compound treatment 5537760.0 511295.75757576 0.565345009310061 0.9696 0.9967 3092511 BCB02_000089 C/C=C/C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4 5810960.0 458000.0 0.5 5665360.0 610000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F10 compound treatment 4140000.0 -886464.24242424 -0.980172684714894 -2.3442 -0.9813 3000859 BCB02_000090 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc(Cl)c2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 3917600.0 -1440000.0 -1.57 3552280.0 -1500000.0 -1.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F11 compound treatment 5733720.0 707255.75757576 0.782020008824376 1.0701 0.9798 3092512 BCB02_000091 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccc(cc5)[N+](=O)[O-] 5787360.0 434000.0 0.48 5648800.0 594000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F12 compound treatment 5469680.0 443215.75757576 0.490068248915416 -0.688 -0.5346 3092513 BCB02_000092 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2Cl)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 4613120.0 -740000.0 -0.81 4186640.0 -868000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F13 compound treatment 5833320.0 806855.75757576 0.892148759342982 1.1295 0.8821 3000860 BCB02_000093 CN(C)c1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 5498880.0 146000.0 0.16 5956240.0 901000.0 0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F14 compound treatment 4166400.0 -860064.24242424 -0.950981931565384 -1.8077 -0.9972 3092514 BCB02_000094 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc3ccccc23)S(=O)(=O)c4ccc(C)cc4)C(C)(C)C 4404840.0 -948000.0 -1.04 3917520.0 -1140000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F15 compound treatment 5660920.0 634455.75757576 0.70152429559391 0.9921 0.8906 3092515 BCB02_000095 COc1cc(cc(OC)c1OC)C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 6128200.0 775000.0 0.85 5222320.0 167000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F16 compound treatment 5107120.0 80655.7575757597 0.0891819056621479 -0.5196 -0.7112 3000861 BCB02_000096 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccc(cc2)C(F)(F)F)S(=O)(=O)c3ccc(C)cc3 4777840.0 -575000.0 -0.63 4697000.0 -358000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F17 mock treatment 5459120.0 432655.75757576 0.478391947655612 0.7221 0.9646 5587920.0 235000.0 0.26 5568280.0 513000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F18 mock treatment 5838200.0 811735.75757576 0.897544625834255 1.3525 0.9663 6226560.0 873000.0 0.96 5541720.0 487000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F19 mock treatment 5744000.0 717535.75757576 0.79338671118714 1.5552 0.9913 6325080.0 972000.0 1.06 5887840.0 833000.0 0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F20 mock treatment 5697360.0 670895.75757576 0.741816380623006 1.0014 0.9788 5845920.0 493000.0 0.54 5506240.0 451000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F21 mock treatment 5172520.0 146055.75757576 0.161495362327979 0.8197 0.8822 5789760.0 437000.0 0.48 5832320.0 777000.0 0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F22 mock treatment 5829600.0 803135.75757576 0.888035516853732 1.0585 0.936 5919160.0 566000.0 0.62 5379160.0 324000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F23 mock treatment 5417960.0 391495.75757576 0.432880909790694 0.7722 0.9976 5799560.0 446000.0 0.49 5469200.0 414000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 F24 mock treatment 4649080.0 -377384.24242424 -0.417277661481847 -0.3171 -0.7389 5316720.0 -36400.0 -0.04 4963120.0 -91800.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G01 compound treatment 4985080.0 -41384.2424242403 -0.0457589850335405 -0.255 -0.7353 3092516 BCB02_000097 CC(C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccccc5 5301200.0 -52000.0 -0.06 4717080.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G02 compound treatment 4697320.0 -329144.24242424 -0.363938194363197 -0.2408 -0.5203 3000862 BCB02_000098 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2C)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 5511920.0 159000.0 0.17 4828640.0 -226000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G03 compound treatment 5202160.0 175695.75757576 0.194268617000383 0.4588 0.9159 3092587 BCB02_000099 CCCCCCCCCCC(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 5510160.0 157000.0 0.17 5481920.0 427000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G04 compound treatment 4881840.0 -144624.24242424 -0.159912521213669 -0.5712 -0.8154 3000863 BCB02_000100 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)C[Si](C)(C)C)c3ccccc3 5199200.0 -154000.0 -0.17 4396440.0 -658000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G05 compound treatment 5797560.0 771095.75757576 0.852608557349555 1.2441 0.9271 3092588 BCB02_000101 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(F)cc5 6254440.0 901000.0 0.99 5368920.0 314000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G06 compound treatment 4713400.0 -313064.24242424 -0.346158371990314 -0.8889 -0.9693 3092589 BCB02_000102 CCOC(=O)C1=CC[C@H](N([C@H]1/C=C/c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 4747120.0 -606000.0 -0.66 4527040.0 -528000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G07 compound treatment 5719600.0 693135.75757576 0.766407378730775 0.2048 0.2442 3000864 BCB02_000103 COc1ccc(C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5)c6ccccc16 5050880.0 -302000.0 -0.33 4974600.0 -80300.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G08 compound treatment 4792720.0 -233744.24242424 -0.258453427300196 -0.3219 -0.8696 3092590 BCB02_000104 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4cccc(Cl)c4 5319720.0 -33400.0 -0.04 4793360.0 -262000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G09 compound treatment 5442000.0 415535.75757576 0.459462186522293 0.8116 0.9791 3092591 BCB02_000105 COc1ccc(cc1OCc2ccccc2)C(O)C3C=CC4C(N3Nc5ccc(cc5)[N+](=O)[O-])C(=O)N(C4=O)c6ccccc6 5676480.0 323000.0 0.35 5644920.0 590000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G10 compound treatment 4575120.0 -451344.24242424 -0.499055998714337 -1.341 -0.9641 3000865 BCB02_000106 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2I)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 4422880.0 -930000.0 -1.02 4252880.0 -802000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G11 compound treatment 4232080.0 -794384.24242424 -0.878358876002513 0.1979 0.1601 3092592 BCB02_000107 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccccn5 5845240.0 492000.0 0.54 5734760.0 680000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G12 compound treatment 5068720.0 42255.7575757597 0.04672262835377 -0.1407 -0.663 3000866 BCB02_000108 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 5203840.0 -149000.0 -0.16 4928520.0 -126000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G13 compound treatment 5514680.0 488215.75757576 0.539825214511171 1.301 0.9328 3092593 BCB02_000109 CCOc1cc(ccc1O)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 6413880.0 1060000.0 1.16 5604840.0 550000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G14 compound treatment 4917880.0 -108584.24242424 -0.120062720323202 -0.8813 -0.8608 3000867 BCB02_000110 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4F 4847560.0 -506000.0 -0.55 4205200.0 -850000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G15 compound treatment 4419240.0 -607224.24242424 -0.671414127538034 -1.1198 -0.9894 3092594 BCB02_000111 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5cc(cc(c5)C(F)(F)F)C(F)(F)F 4669920.0 -683000.0 -0.75 4536920.0 -518000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G16 compound treatment 5334160.0 307695.75757576 0.340222382747932 0.7483 0.9352 3092595 BCB02_000112 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(SC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OCc5ccccc5)c(OC)c4 5957560.0 604000.0 0.66 5347880.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G17 mock treatment 5301880.0 275415.75757576 0.304530052760577 1.0435 0.9426 6001560.0 648000.0 0.71 5844920.0 790000.0 0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G18 mock treatment 5880880.0 854415.75757576 0.944736343425962 1.0527 0.9269 5685520.0 332000.0 0.36 5567640.0 513000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G19 mock treatment 5572800.0 546335.75757576 0.604089099853955 1.2142 0.9284 6341760.0 989000.0 1.08 5469760.0 415000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G20 mock treatment 5394960.0 368495.75757576 0.40744957181953 0.596 0.9583 5741760.0 389000.0 0.43 5253560.0 199000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G21 mock treatment 5483480.0 457015.75757576 0.505327051698114 1.2994 0.9717 6213680.0 861000.0 0.94 5854920.0 800000.0 0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G22 mock treatment 5489600.0 463135.75757576 0.512093999019137 0.8898 0.905 6093040.0 740000.0 0.81 5272920.0 218000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G23 mock treatment 5273160.0 246695.75757576 0.272774051607019 0.448 0.9812 5638720.0 286000.0 0.31 5244760.0 190000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 G24 mock treatment 4749120.0 -277344.24242424 -0.30666239841075 0.255 0.3514 5947000.0 594000.0 0.65 5152520.0 97600.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H01 compound treatment 4779840.0 -246624.24242424 -0.272694976564048 -0.2724 -0.7235 3000868 BCB02_000113 CC(=CCC/C(=C/C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)/C)C 5121360.0 -232000.0 -0.25 5109360.0 54500.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H02 compound treatment 4349440.0 -677024.24242424 -0.748592709728783 -0.4799 -0.6384 3092596 BCB02_000114 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccc(cc2)C(C)C)S(=O)(=O)c3ccc(C)cc3 5293480.0 -59700.0 -0.07 5037760.0 -17100.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H03 compound treatment 5543200.0 516735.75757576 0.571360073595414 1.1948 0.9912 3092597 BCB02_000115 OC(CCc1ccccc1)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 6080000.0 727000.0 0.8 5754520.0 700000.0 0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H04 compound treatment 5109600.0 83135.7575757597 0.0919240673216473 0.1478 0.3884 3000869 BCB02_000116 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccccc2F)S(=O)(=O)c3ccc(C)cc3 5201680.0 -151000.0 -0.17 5383760.0 329000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H05 compound treatment 5342040.0 315575.75757576 0.348935380278922 0.7874 0.8682 3092598 BCB02_000117 COc1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 5538240.0 185000.0 0.2 5864160.0 809000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H06 compound treatment 5190440.0 163975.75757576 0.181309691738555 0.0311 0.0708 3000870 BCB02_000118 CCOC(=O)C1=C[C@@H](CC)N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3 5546120.0 193000.0 0.21 4717280.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H07 compound treatment 5311440.0 284975.75757576 0.315100643673809 0.6822 0.9239 3000871 BCB02_000119 O=c1cccc(o1)c2ccccc2 5577400.0 224000.0 0.25 5673680.0 619000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H08 compound treatment 5179920.0 153455.75757576 0.169677618892614 -0.5558 -0.5331 3092599 BCB02_000120 CCOC(=O)C1=CCN(C1c2ccccc2)S(=O)(=O)c3ccc(C)cc3 5253200.0 -100000.0 -0.11 4035680.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H09 compound treatment 5279680.0 253215.75757576 0.279983283066671 0.858 0.9479 3000872 BCB02_000121 COc1cccc(c1)c2cccc(=O)o2 5979000.0 626000.0 0.69 5573840.0 519000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H10 compound treatment 4450360.0 -576104.24242424 -0.637004421552702 -1.5809 -0.9301 3092600 BCB02_000122 CCC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(=O)OCC 4732960.0 -620000.0 -0.68 3637960.0 -1420000.0 -1.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H11 compound treatment 5029680.0 3215.75757575966 0.00355569642358585 0.964 0.8148 1984103 BCB02_000123 Cc1ccc(cc1)c2cccc(=O)o2 6044080.0 691000.0 0.76 5961160.0 906000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H12 compound treatment 5161200.0 134735.75757576 0.14897872120478 -0.9471 -0.737 3092601 BCB02_000124 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 4645080.0 -708000.0 -0.78 4044480.0 -1010000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H13 compound treatment 5544120.0 517655.75757576 0.572377327114261 1.039 0.9679 3000873 BCB02_000125 Clc1cccc(c1)c2cccc(=O)o2 6086280.0 733000.0 0.8 5477760.0 423000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H14 compound treatment 5593920.0 567455.75757576 0.627441702373563 1.0483 0.9937 3000874 BCB02_000126 Cc1ccc(cc1)[C@@H]2N(CC=C2C(=O)O)S(=O)(=O)c3ccc(C)cc3 5970320.0 617000.0 0.68 5565520.0 511000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H15 compound treatment 5575040.0 548575.75757576 0.606565891030277 1.0415 0.9999 3000875 BCB02_000127 Clc1ccccc1c2cccc(=O)o2 5891280.0 538000.0 0.59 5660880.0 606000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H16 compound treatment 5246200.0 219735.75757576 0.242964100663429 1.2169 0.8912 3092602 BCB02_000128 C[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 6371640.0 1020000.0 1.12 5801720.0 747000.0 0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H17 mock treatment 5407600.0 381135.75757576 0.421425750600205 1.1005 0.9344 6242680.0 890000.0 0.97 5563600.0 509000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H18 mock treatment 5439400.0 412935.75757576 0.456587339621205 1.2541 0.9521 5984960.0 632000.0 0.69 6074920.0 1020000.0 1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H19 mock treatment 5548080.0 521615.75757576 0.576755940086687 1.0479 0.9878 5814000.0 461000.0 0.5 5785880.0 731000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H20 mock treatment 5922840.0 896375.75757576 0.991131949568137 0.8537 0.8001 5451080.0 97900.0 0.11 5433800.0 379000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H21 mock treatment 4931880.0 -94584.2424242403 -0.104582775471189 0.4199 0.7021 5715400.0 362000.0 0.4 5488520.0 434000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H22 mock treatment 5084560.0 58095.7575757597 0.0642370802434759 0.0507 0.5089 5411840.0 58700.0 0.06 5014320.0 -40600.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H23 mock treatment 5393480.0 367015.75757576 0.405813120506603 0.6298 0.9106 5847480.0 494000.0 0.54 5198080.0 143000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 H24 mock treatment 5260640.0 234175.75757576 0.258930558067934 0.0051 0.0163 5238520.0 -115000.0 -0.13 4930800.0 -124000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I01 compound treatment 4505840.0 -520624.24242424 -0.575659611524869 -0.7075 -0.7533 3092603 BCB02_000129 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5cccs5 4680120.0 -673000.0 -0.74 5141840.0 86900.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I02 compound treatment 4668240.0 -358224.24242424 -0.396092251241521 -0.8121 -0.8582 3000947 BCB02_000130 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(cc2)[N+](=O)[O-])S(=O)(=O)c3ccc(C)cc3)c4ccc(F)cc4 4583440.0 -770000.0 -0.84 4887880.0 -167000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I03 compound treatment 5370040.0 343575.75757576 0.379895269982948 0.7867 0.9438 3000948 BCB02_000131 OC(C(c1ccccc1)c2ccccc2)C3C=CC4C(N3Nc5ccc(cc5)[N+](=O)[O-])C(=O)N(C4=O)c6ccccc6 5634040.0 281000.0 0.31 5727640.0 673000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I04 compound treatment 5011280.0 -15184.2424242403 -0.0167893739533452 -0.5111 -0.6976 3000949 BCB02_000132 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(cc2)[N+](=O)[O-])S(=O)(=O)c3ccc(C)cc3)c4cccc(Br)c4 4698760.0 -654000.0 -0.72 4903560.0 -151000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I05 compound treatment 5188240.0 161775.75757576 0.178877128976096 0.4442 0.9522 3000950 BCB02_000133 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5cccc6ccccc56 5554200.0 201000.0 0.22 5423920.0 369000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I06 compound treatment 4764320.0 -262144.24242424 -0.28985560114285 -0.6042 -0.578 3000951 BCB02_000134 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3 5556480.0 203000.0 0.22 4079160.0 -976000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I07 compound treatment 5030480.0 4015.75757575966 0.00444026470084372 0.8103 0.7551 3092604 BCB02_000135 C/C=C/C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 6260360.0 907000.0 0.99 5459000.0 404000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I08 compound treatment 4686880.0 -339584.24242424 -0.375481810381412 -1.4741 -0.9243 3000952 BCB02_000136 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccc4ccccc34 4244960.0 -1110000.0 -1.21 4094280.0 -961000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I09 compound treatment 5394120.0 367655.75757576 0.40652077512841 0.7088 0.973 3092605 BCB02_000137 CCC(CC)C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 5836560.0 483000.0 0.53 5345640.0 291000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I10 compound treatment 4971280.0 -55184.2424242403 -0.0610177878162388 -0.6566 -0.8541 3092606 BCB02_000138 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(F)cc3 4919960.0 -433000.0 -0.47 4455160.0 -600000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I11 compound treatment 5392880.0 366415.75757576 0.40514969429866 0.8225 0.9789 3000953 BCB02_000139 CC(C)C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 5914800.0 562000.0 0.62 5457920.0 403000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I12 compound treatment 4570320.0 -456144.24242424 -0.504363408377885 -1.8323 -0.9347 3092607 BCB02_000140 CCOC(=O)[C@@H]1N([C@@H](CC=C1C(=O)OCC)c2ccccc2)S(=O)(=O)c3ccc(C)cc3 4029960.0 -1320000.0 -1.45 3839000.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I13 compound treatment 6498120.0 1471655.75757576 1.62722499774427 1.2818 0.7508 3092678 BCB02_000141 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5cccc(O)c5 5819120.0 466000.0 0.51 5137280.0 82400.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I14 compound treatment 5402440.0 375975.75757576 0.415720285211891 0.6234 0.9596 3000954 BCB02_000142 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OC)cc4 5765800.0 413000.0 0.45 5266320.0 211000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I15 compound treatment 5210800.0 184335.75757576 0.203821954394768 0.5811 0.944 3092679 BCB02_000143 OB(O)c1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 5799240.0 446000.0 0.49 5367880.0 313000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I16 compound treatment 4594560.0 -431904.24242424 -0.477560989576971 -1.5247 -0.9495 3000955 BCB02_000144 CCOC(=O)C1=CC[C@H](N([C@H]1C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 4431200.0 -922000.0 -1.01 3905360.0 -1150000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I17 mock treatment 5488840.0 462375.75757576 0.511253659155742 0.9016 0.9854 5933120.0 580000.0 0.64 5468720.0 414000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I18 mock treatment 5442600.0 416135.75757576 0.460125612730237 0.5119 0.691 5868160.0 515000.0 0.56 4917840.0 -137000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I19 mock treatment 5267560.0 241095.75757576 0.266582073666214 0.3778 0.9868 5541880.0 189000.0 0.21 5235440.0 181000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I20 mock treatment 4906080.0 -120384.24242424 -0.133110102412755 -0.1317 -0.1406 4712800.0 -640000.0 -0.7 5659040.0 604000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I21 mock treatment 4941920.0 -84544.2424242403 -0.0934814435916028 0.2717 0.6394 5683560.0 330000.0 0.36 5256360.0 201000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I22 mock treatment 4802760.0 -223704.24242424 -0.24735209542061 0.3842 0.48 6030640.0 677000.0 0.74 5225200.0 170000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I23 mock treatment 4938200.0 -88264.2424242403 -0.0975946860808519 -0.2309 -0.4454 5513520.0 160000.0 0.18 4578640.0 -476000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 I24 mock treatment 5459280.0 432815.75757576 0.478568861311063 -0.1454 -0.2006 4908360.0 -445000.0 -0.49 4812480.0 -242000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J01 compound treatment 4528280.0 -498184.24242424 -0.550847471347786 -0.9254 -0.999 3000956 BCB02_000145 CCCc1cccc(=O)o1 4895600.0 -458000.0 -0.5 4506000.0 -549000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J02 compound treatment 4543400.0 -483064.24242424 -0.534129130907612 -0.6892 -0.9579 3092680 BCB02_000146 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 4973360.0 -380000.0 -0.42 4812160.0 -243000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J03 compound treatment 5277800.0 251335.75757576 0.277904547615115 0.6706 0.8769 3000957 BCB02_000147 Fc1ccc(cc1)c2cccc(=O)o2 5977640.0 624000.0 0.68 5253880.0 199000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J04 compound treatment 5184200.0 157735.75757576 0.174410059175944 0.1524 0.3986 3092681 BCB02_000148 CCC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 5609800.0 257000.0 0.28 4864040.0 -191000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J05 compound treatment 5381240.0 354775.75757576 0.392279225864558 0.6875 0.9753 3000958 BCB02_000149 O=c1cccc(o1)c2ccc(C#N)cc2 5818280.0 465000.0 0.51 5343040.0 288000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J06 compound treatment 5437440.0 410975.75757576 0.454420147341923 -0.342 -0.318 3000959 BCB02_000150 CC(C)[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 4465760.0 -887000.0 -0.97 4980280.0 -74600.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J07 compound treatment 4848840.0 -177624.24242424 -0.196400962650556 0.284 0.5402 3092682 BCB02_000151 FC(F)(F)c1ccc(cc1)c2cccc(=O)o2 5647880.0 295000.0 0.32 5419080.0 364000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J08 compound treatment 5617760.0 591295.75757576 0.653801837035848 0.6866 0.8924 3092683 BCB02_000152 Cc1ccc(cc1)[C@@H]2N([C@@H](C=C2C(=O)O)C(C)(C)C)S(=O)(=O)c3ccc(C)cc3 5691680.0 339000.0 0.37 5219040.0 164000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J09 compound treatment 4891240.0 -135224.24242424 -0.149518843955889 0.3282 0.5906 3000960 BCB02_000153 FC(F)(F)c1ccccc1c2cccc(=O)o2 5790320.0 437000.0 0.48 5293200.0 238000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J10 compound treatment 5180640.0 154175.75757576 0.170473730342146 0.1711 0.8109 3092684 BCB02_000154 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(=O)O 5466680.0 114000.0 0.12 5056440.0 1540.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J11 compound treatment 5171440.0 144975.75757576 0.160301195153681 0.6762 0.8135 3000961 BCB02_000155 O=c1cccc(o1)c2ccc3ccccc3c2 6068280.0 715000.0 0.78 5281880.0 227000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J12 compound treatment 5046200.0 19735.7575757597 0.0218220313489609 0.0131 0.2778 3000962 BCB02_000156 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C#N)cc3)C(=O)O 5326520.0 -26600.0 -0.03 5084880.0 30000.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J13 compound treatment 5318000.0 291535.75757576 0.322354103547323 0.6112 0.9975 3092685 BCB02_000157 O=c1cccc(o1)c2ccco2 5674880.0 322000.0 0.35 5437440.0 383000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J14 compound treatment 4950040.0 -76424.2424242403 -0.0845030755774353 0.1167 0.5275 3092686 BCB02_000158 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(OC)cc3)C(=O)O 5466480.0 113000.0 0.12 5216920.0 162000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J15 compound treatment 5284040.0 257575.75757576 0.284804180177726 0.2326 0.7749 3000963 BCB02_000159 O=c1cccc(CCc2ccccc2)o1 5378200.0 25000.0 0.03 5145160.0 90300.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J16 compound treatment 5089640.0 63175.7575757597 0.0698540888040634 -0.0062 -0.0234 3092687 BCB02_000160 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3cccc(Cl)c3)C(=O)O 5476960.0 124000.0 0.14 4839520.0 -215000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J17 mock treatment 4878720.0 -147744.24242424 -0.163362337494975 0.2507 0.5173 5737120.0 384000.0 0.42 5231320.0 176000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J18 mock treatment 4984360.0 -42104.2424242403 -0.0465550964830726 0.277 0.6975 5677640.0 324000.0 0.36 5225200.0 170000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J19 mock treatment 5168400.0 141935.75757576 0.156939835700101 0.131 0.7209 5335280.0 -17900.0 -0.02 5144200.0 89300.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J20 mock treatment 4995000.0 -31464.2424242403 -0.0347903383955429 0.4334 0.6997 5536120.0 183000.0 0.2 5637840.0 583000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J21 mock treatment 4977000.0 -49464.2424242403 -0.054693124633845 -0.05 -0.8162 5328240.0 -24900.0 -0.03 5050240.0 -4660.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J22 mock treatment 4866680.0 -159784.24242424 -0.176675090067706 -0.0496 -0.2641 5394760.0 41600.0 0.05 5099880.0 45000.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J23 mock treatment 5113760.0 87295.7575757597 0.0965238223633882 0.1414 0.4772 5588680.0 236000.0 0.26 4945800.0 -109000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 J24 mock treatment 5838400.0 811935.75757576 0.897765767903569 -0.2395 -0.1794 4972440.0 -381000.0 -0.42 4162480.0 -892000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K01 compound treatment 4541920.0 -484544.24242424 -0.535765582220539 -0.9985 -0.9771 3000964 BCB02_000161 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccc(C#N)cc5 4671480.0 -682000.0 -0.75 4609400.0 -445000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K02 compound treatment 3056080.0 -1970384.24242424 -2.17867424357159 -3.8195 -0.9872 3092688 BCB02_000162 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccncc3 2929640.0 -2420000.0 -2.65 3278480.0 -1780000.0 -1.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K03 compound treatment 5197560.0 171095.75757576 0.18918234940615 0.2513 0.9739 3092689 BCB02_000163 CC(C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccccc5 5480120.0 127000.0 0.14 5161600.0 107000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K04 compound treatment 3156440.0 -1870024.24242424 -2.06770515318959 -3.241 -0.9956 3000965 BCB02_000164 CCOC(=O)C1=CC[C@H](N([C@H]1C=C(C)C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 3854480.0 -1500000.0 -1.64 3157080.0 -1900000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K05 compound treatment 4886680.0 -139784.24242424 -0.154560883136259 -0.2282 -0.3813 3092690 BCB02_000165 CC(CC(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(C)o5 5600040.0 247000.0 0.27 4545680.0 -509000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K06 compound treatment 4444240.0 -582224.24242424 -0.643771368873725 -1.129 -0.7505 3000966 BCB02_000166 CCOC(=O)C1=CC[C@H](N([C@H]1C#N)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 5396080.0 42900.0 0.05 3701000.0 -1350000.0 -1.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K07 compound treatment 5178160.0 151695.75757576 0.167731568682647 0.4649 0.8725 3092691 BCB02_000167 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5cccs5 5792320.0 439000.0 0.48 5210960.0 156000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K08 compound treatment 4262920.0 -763544.24242424 -0.844258768914222 -1.4708 -1.0 3092692 BCB02_000168 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(OC)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 4576160.0 -777000.0 -0.85 4205680.0 -849000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K09 compound treatment 5011760.0 -14704.2424242403 -0.0162586329869905 -0.0866 -0.4672 3000967 BCB02_000169 OC(Cc1ccccc1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 5189760.0 -163000.0 -0.18 5100000.0 45100.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K10 compound treatment 4868880.0 -157584.24242424 -0.174242527305247 -0.2104 -0.9556 3092693 BCB02_000170 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4C(F)(F)F 5270400.0 -82800.0 -0.09 4955640.0 -99300.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K11 compound treatment 5576680.0 550215.75757576 0.608379255998656 0.6481 0.856 3000968 BCB02_000171 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(C#N)cc5 5759880.0 407000.0 0.45 5123360.0 68500.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K12 compound treatment 4443040.0 -583424.24242424 -0.645098221289612 -1.5177 -0.9581 3092694 BCB02_000172 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(cc4)C(F)(F)F 4676560.0 -677000.0 -0.74 3816720.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K13 compound treatment 5289720.0 263255.75757576 0.291084614946257 0.5793 0.9846 3092695 BCB02_000173 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc6OCOc6c5 5621600.0 268000.0 0.29 5471680.0 417000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K14 compound treatment 3162560.0 -1863904.24242424 -2.06093820586856 -2.9724 -0.9887 3000969 BCB02_000174 CCOC(=O)C1=CC[C@H](N([C@H]1C=C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 4044400.0 -1310000.0 -1.43 3406720.0 -1650000.0 -1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K15 compound treatment 5351600.0 325135.75757576 0.359505971192154 0.1864 0.4889 3092696 BCB02_000175 CC1(C)[C@H]2C[C@@H]1C=C(C2)C(O)C3C=CC4C(N3Nc5ccc(cc5)[N+](=O)[O-])C(=O)N(C4=O)c6ccccc6 5256280.0 -96900.0 -0.11 5124080.0 69200.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K16 compound treatment 4930040.0 -96424.2424242403 -0.106617282508882 -1.4028 -0.8271 3000970 BCB02_000176 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(cc2)[N+](=O)[O-])S(=O)(=O)c3ccc(C)cc3)c4ccc(cc4)N(CC)CC 4028600.0 -1320000.0 -1.45 4185520.0 -869000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K17 mock treatment 4983320.0 -43144.2424242403 -0.0477050352435079 -0.2328 -0.8593 5248320.0 -105000.0 -0.11 4815040.0 -240000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K18 mock treatment 4844400.0 -182064.24242424 -0.201310316589337 0.1566 0.3962 5528160.0 175000.0 0.19 5334760.0 280000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K19 mock treatment 5016720.0 -9744.24242424034 -0.0107743096679917 -0.0844 -0.7486 5329120.0 -24000.0 -0.03 4946160.0 -109000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K20 mock treatment 4988800.0 -37664.2424242403 -0.0416457425442914 -0.3043 -0.7582 5263120.0 -90000.0 -0.1 4669440.0 -385000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K21 mock treatment 5108000.0 81535.7575757597 0.0901549307671315 -0.0207 -0.056 5519520.0 166000.0 0.18 4747880.0 -307000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K22 mock treatment 4863480.0 -162984.24242424 -0.180213363176737 0.0472 0.1823 5480240.0 127000.0 0.14 5177200.0 122000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K23 mock treatment 4678160.0 -348304.24242424 -0.385123604603523 -0.4594 -0.9163 5077200.0 -276000.0 -0.3 4946880.0 -108000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 K24 mock treatment 4515960.0 -510504.24242424 -0.564469822817557 -0.9153 -0.9959 4841440.0 -512000.0 -0.56 4596000.0 -459000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L01 compound treatment 4400760.0 -625704.24242424 -0.691847654742691 -1.2189 -0.9999 3000971 BCB02_000177 [O-][N+](=O)c1ccc(cc1)c2cccc(=O)o2 4709360.0 -644000.0 -0.71 4343200.0 -712000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L02 compound treatment 4285320.0 -741144.24242424 -0.819490857151001 -0.9444 -0.9422 3092697 BCB02_000178 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(cc2)[N+](=O)[O-])c3ccccc3)C(=O)O 4978240.0 -375000.0 -0.41 4650640.0 -404000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L03 compound treatment 5023960.0 -2504.24242424034 -0.00276896675880794 -0.0628 -0.6264 3000972 BCB02_000179 O=c1cccc(/C=C/c2ccccc2)o1 5347720.0 -5440.0 -0.01 4955160.0 -99700.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L04 compound treatment 5036000.0 9535.75757575966 0.010543785813923 0.124 0.7507 3092698 BCB02_000180 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccco3)C(=O)O 5497720.0 145000.0 0.16 5100640.0 45700.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L05 compound treatment 4973400.0 -53064.2424242403 -0.0586736818815055 0.4091 0.7423 3000973 BCB02_000181 O=c1cccc(o1)c2cccc3ccccc23 5753320.0 400000.0 0.44 5382680.0 328000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L06 compound treatment 5347920.0 321455.75757576 0.355436957116767 0.3594 0.8062 3092699 BCB02_000182 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3cccc4ccccc34)C(=O)O 5598920.0 246000.0 0.27 5052920.0 -1980.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L07 compound treatment 4614120.0 -412344.24242424 -0.455933295198016 -0.1265 -0.2207 3000974 BCB02_000183 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(Cl)c2)c3cccc(Cl)c3 5657720.0 305000.0 0.33 4958600.0 -96300.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L08 compound treatment 5194920.0 168455.75757576 0.186263274091199 0.2435 0.9739 3092700 BCB02_000184 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(Br)cc3)C(=O)O 5454480.0 101000.0 0.11 5179000.0 124000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L09 compound treatment 4144120.0 -882344.24242424 -0.975617158087016 -1.8263 -0.9971 3092701 BCB02_000185 CCOC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(c2)[N+](=O)[O-])c3cccc(c3)[N+](=O)[O-] 4418560.0 -935000.0 -1.02 3894960.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L10 compound treatment 5525720.0 499255.75757576 0.55203225673733 0.2174 0.2485 3000975 BCB02_000186 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(cc3)C(C)C)C(=O)O 5703960.0 351000.0 0.38 4497280.0 -558000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L11 compound treatment 4887400.0 -139064.24242424 -0.153764771686727 -0.3661 -0.9644 3092771 BCB02_000187 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccccn2)c3ccccn3 5179920.0 -173000.0 -0.19 4765240.0 -290000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L12 compound treatment 5051920.0 25455.7575757597 0.0281466945313547 0.1522 0.7927 3000976 BCB02_000188 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](C=C([C@@H]2c3ccccc3)C(=O)O)C(C)(C)C 5519640.0 166000.0 0.18 5107840.0 52900.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L13 compound treatment 4924960.0 -101504.24242424 -0.11223429106947 -0.3505 -0.5584 3092772 BCB02_000189 COC(=O)c1cccc(c1)[C@@H]2C/C(=C\C(=O)OC(C)C)/O[C@@H](O2)c3cccc(c3)C(=O)OC 5455800.0 103000.0 0.11 4449800.0 -605000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L14 compound treatment 4959720.0 -66744.2424242403 -0.0737997994226151 -0.4213 -0.7829 3092773 BCB02_000190 CC(C)[C@@H]1[C@@H](Sc2ccccc2)[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 4884040.0 -469000.0 -0.51 4913280.0 -142000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L15 compound treatment 4634600.0 -391864.24242424 -0.433288347300214 -1.1724 -0.8203 3000977 BCB02_000191 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2ccc(C#N)cc2)c3ccc(C#N)cc3 5115160.0 -238000.0 -0.26 3722920.0 -1330000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L16 compound treatment 5137920.0 111455.75757576 0.123237784336576 -0.3883 -0.6615 3092774 BCB02_000192 CC[C@@H]1C(Sc2ccccc2)C([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 4917080.0 -436000.0 -0.48 4737840.0 -317000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L17 mock treatment 4645520.0 -380944.24242424 -0.421213990315644 -0.3091 -0.7196 5286040.0 -67100.0 -0.07 5014400.0 -40500.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L18 mock treatment 5253640.0 227175.75757576 0.251190585641927 0.1838 0.4099 5145960.0 -207000.0 -0.23 5347920.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L19 mock treatment 5207800.0 181335.75757576 0.200504823355051 -0.487 -0.6365 4864760.0 -488000.0 -0.53 4547520.0 -507000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L20 mock treatment 4466200.0 -560264.24242424 -0.619489969662997 -0.3261 -0.4652 5167800.0 -185000.0 -0.2 5311680.0 257000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L21 mock treatment 4749960.0 -276504.24242424 -0.305733601719629 -0.4807 -0.9227 5240360.0 -113000.0 -0.12 4653080.0 -402000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L22 mock treatment 5147680.0 121215.75757576 0.134029517319122 -0.2305 -0.4665 5296800.0 -56400.0 -0.06 4584960.0 -470000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L23 mock treatment 5000600.0 -25864.2424242403 -0.0285983604547378 -0.33 -0.8158 5025160.0 -328000.0 -0.36 4871840.0 -183000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 L24 mock treatment 4488800.0 -537664.24242424 -0.594500915830462 -0.9734 -0.9815 4974840.0 -378000.0 -0.41 4380160.0 -675000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M01 compound treatment 4644040.0 -382424.24242424 -0.422850441628572 -1.1529 -0.9604 3000978 BCB02_000193 CC1(C)[C@H]2C[C@H]1C=C(C2)C(O)C3C=CC4C(N3Nc5ccccc5F)C(=O)N(C4=O)c6ccccc6 4535720.0 -817000.0 -0.9 4378520.0 -676000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M02 compound treatment 4299040.0 -727424.24242424 -0.804320511196029 -1.5047 -0.9547 3001047 BCB02_000194 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(c(OC)c4)c5ccc(OCc6ccccc6)cc5 4232120.0 -1120000.0 -1.23 4482760.0 -572000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M03 compound treatment 4775280.0 -251184.24242424 -0.277737015744418 -0.8521 -0.8395 3092775 BCB02_000195 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(I)cc4)C(=O)N(C5CCCCC5)C3=O)cc1 4492880.0 -860000.0 -0.94 4799800.0 -255000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M04 compound treatment 5068400.0 41935.7575757597 0.0463688010428669 -0.452 -0.7298 3001048 BCB02_000196 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(cc4)[N+](=O)[O-] 4849320.0 -504000.0 -0.55 4778400.0 -276000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M05 compound treatment 5190640.0 164175.75757576 0.18153083380787 0.326 0.9117 3092776 BCB02_000197 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(cc4)[N+](=O)[O-])C(=O)N(C5CCCCC5)C3=O)cc1 5622840.0 270000.0 0.3 5142400.0 87500.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M06 compound treatment 4439640.0 -586824.24242424 -0.648857636467958 -1.3587 -0.9206 3001049 BCB02_000198 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(cc3)[N+](=O)[O-] 4218720.0 -1130000.0 -1.24 4594480.0 -460000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M07 compound treatment 5451360.0 424895.75757576 0.46981163536621 0.1954 0.3978 3092777 BCB02_000199 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(OC)cc4)C(=O)N(C5CCCCC5)C3=O)cc1 5222760.0 -130000.0 -0.14 5066280.0 11400.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M08 compound treatment 4158760.0 -867704.24242424 -0.959429558613197 -2.0141 -0.9924 3092778 BCB02_000200 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(CC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 4189640.0 -1160000.0 -1.27 3804400.0 -1250000.0 -1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M09 compound treatment 5538320.0 511855.75757576 0.565964207104141 0.3281 0.5771 3001050 BCB02_000201 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(cc4)N(C)C)C(=O)N(C5CCCCC5)C3=O)cc1 5319040.0 -34100.0 -0.04 5094480.0 39600.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M10 compound treatment 3269840.0 -1756624.24242424 -1.94231759988828 -3.5041 -0.9976 3001168 BCB02_000202 CCOC(=O)C1=C(N([C@@H](CC1)c2ccccc2)S(=O)(=O)CC[Si](C)(C)C)C(=O)OCC 3326520.0 -2030000.0 -2.22 3154240.0 -1900000.0 -1.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M11 compound treatment 4871280.0 -155184.24242424 -0.171588822473473 -0.0199 -0.1005 3092779 BCB02_000203 COc1ccc(NN2C3C(C=CC2C(O)c4cc(OC)c(OC)c(OC)c4)C(=O)N(C5CCCCC5)C3=O)cc1 5425040.0 71900.0 0.08 5113160.0 58300.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M12 compound treatment 4318080.0 -708384.24242424 -0.783267786197292 -1.819 -0.974 3092780 BCB02_000204 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)c4cc(Cl)ccc4Cl 4098920.0 -1250000.0 -1.37 4064600.0 -990000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M13 compound treatment 5672040.0 645575.75757576 0.713819794647794 0.6563 0.8169 3001169 BCB02_000205 COc1ccc(NN2C3C(C=CC2C(O)C4=CC[C@H](CC4)C(=C)C)C(=O)N(C5CCCCC5)C3=O)cc1 5685600.0 332000.0 0.36 5113600.0 58700.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M14 compound treatment 4826720.0 -199744.24242424 -0.220859275516736 -0.8307 -0.9223 3092781 BCB02_000206 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(cc2)[N+](=O)[O-])c3ccccc3 4704000.0 -649000.0 -0.71 4549720.0 -505000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M15 compound treatment 5230520.0 204055.75757576 0.225626562429175 0.0688 0.1627 3001170 BCB02_000207 COc1ccc(NN2C3C(C=CC2C(O)c4ccco4)C(=O)N(C5CCCCC5)C3=O)cc1 5530280.0 177000.0 0.19 4755520.0 -299000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M16 mock treatment 5087040.0 60575.7575757597 0.0669792419029753 -0.3042 -0.4735 5392920.0 39800.0 0.04 4419800.0 -635000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M17 mock treatment 4969440.0 -57024.2424242403 -0.0630522948539319 -0.1969 -0.6482 5082400.0 -271000.0 -0.3 5073400.0 18500.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M18 mock treatment 4872480.0 -153984.24242424 -0.170261970057586 -0.4524 -0.9706 5082160.0 -271000.0 -0.3 4739480.0 -315000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M19 mock treatment 5070160.0 43695.7575757597 0.0483148512528342 -0.3176 -0.7381 5119720.0 -233000.0 -0.26 4713440.0 -341000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M20 mock treatment 5069240.0 42775.7575757597 0.0472975977339876 -0.2499 -0.7071 5189440.0 -164000.0 -0.18 4755080.0 -300000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M21 mock treatment 4587000.0 -439464.24242424 -0.485920159797058 -1.0454 -0.9899 4774760.0 -578000.0 -0.63 4365960.0 -689000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M22 mock treatment 4702160.0 -324304.24242424 -0.358586556285787 -0.6251 -0.9819 4944640.0 -409000.0 -0.45 4779120.0 -276000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M23 mock treatment 4784520.0 -241944.24242424 -0.267520252142089 -0.8269 -0.93 4951600.0 -402000.0 -0.44 4332600.0 -722000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 M24 mock treatment 4337480.0 -688984.24242424 -0.761817005473788 -1.584 -0.9863 4327320.0 -1030000.0 -1.12 4199680.0 -855000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N01 compound treatment 4799240.0 -227224.24242424 -0.251244195840544 -1.4616 -0.8951 3092782 BCB02_000208 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccc(cc2)C(F)(F)F)c3ccc(cc3)C(F)(F)F 4275560.0 -1080000.0 -1.18 3958680.0 -1100000.0 -1.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N02 compound treatment 4853080.0 -173384.24242424 -0.191712750781089 -0.8676 -0.9042 3092783 BCB02_000209 CCC[C@@H]1[C@@H](Sc2ccccc2)[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 4653400.0 -700000.0 -0.77 4512120.0 -543000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N03 compound treatment 4745400.0 -281064.24242424 -0.310775640899999 -0.4431 -0.8736 3001171 BCB02_000210 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2ccc([Ac])cc2)c3ccc([Ac])cc3 4991360.0 -362000.0 -0.4 4994680.0 -60200.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N04 compound treatment 5113360.0 86895.7575757597 0.0960815382247593 0.281 0.3888 3092784 BCB02_000211 CCS[C@@H]1[C@@H](CC)N([C@H]([C@@H]1C(=O)O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3 5958320.0 605000.0 0.66 4783840.0 -271000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N05 compound treatment 4312600.0 -713864.24242424 -0.789327078896508 -1.3696 -0.9913 3001172 BCB02_000212 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccc([Ac])cc2)c3ccc([Ac])cc3 4747800.0 -605000.0 -0.66 4138200.0 -917000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N06 compound treatment 5177880.0 151415.75757576 0.167421969785607 -0.1108 -0.1684 3092785 BCB02_000213 CCOC1=C2C(N(CC2C3C(C1)C(=O)N(C3=O)c4ccccc4)S(=O)(=O)c5ccc(C)cc5)c6ccc(C)cc6 4812120.0 -541000.0 -0.59 5287160.0 232000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N07 compound treatment 3867160.0 -1159304.24242424 -1.28185469567369 -2.1466 -0.9815 3092786 BCB02_000214 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(c2)C(F)(F)F)c3cccc(c3)C(F)(F)F 3972600.0 -1380000.0 -1.51 4133960.0 -921000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N08 compound treatment 4573920.0 -452544.24242424 -0.500382851130224 -0.7257 -0.9881 3001173 BCB02_000215 CCOC1=C2C(N(CC2n3n(C1)c(=O)n(c4ccccc4)c3=O)S(=O)(=O)c5ccc(C)cc5)c6ccc(C)cc6 4973360.0 -380000.0 -0.42 4715560.0 -339000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N09 compound treatment 2271240.0 -2755224.24242424 -3.04647995197542 -4.7723 -0.9962 3092787 BCB02_000216 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2cccc(c2)C(F)(F)F)c3cccc(c3)C(F)(F)F 2831120.0 -2520000.0 -2.76 2606280.0 -2450000.0 -2.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N10 compound treatment 4714040.0 -312424.24242424 -0.345450717368508 -0.2091 -0.6044 3001174 BCB02_000217 Cc1ccc(cc1)C2C3C(CN2S(=O)(=O)c4ccc(C)cc4)C5C(CC3=O)C(=O)N(C5=O)c6ccccc6 5355760.0 2600.0 0.0 5035320.0 -19600.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N11 compound treatment 4599800.0 -426664.24242424 -0.471767067360932 -0.8514 -0.9045 3092788 BCB02_000218 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccccc2C(F)(F)F)c3ccccc3C(F)(F)F 4636520.0 -717000.0 -0.78 4837600.0 -217000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N12 compound treatment 5171960.0 145495.75757576 0.160876164533898 1.0892 0.7069 3092789 BCB02_000219 CCN1C(=O)C2CC(=O)C3C(N(CC3C2C1=O)S(=O)(=O)c4ccc(C)cc4)c5ccc(C)cc5 6739600.0 1390000.0 1.52 5261440.0 207000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N13 compound treatment 3761560.0 -1264904.24242424 -1.39861770827173 -2.8414 -0.9941 3001175 BCB02_000220 CON(C)C(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(Cl)c2)c3cccc(Cl)c3 3801200.0 -1550000.0 -1.7 3238200.0 -1820000.0 -1.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N14 compound treatment 4521400.0 -505064.24242424 -0.558454758532203 -0.5149 -0.784 3092790 BCB02_000221 CC[C@@H]1[C@@H]2[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)CC5C2C(=O)N(CC)C5=O 5364160.0 11000.0 0.01 4710680.0 -344000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N15 compound treatment 4803960.0 -222504.24242424 -0.246025243004723 0.3201 0.3015 3001176 BCB02_000222 CC(C)OC(=O)CC(=O)CC(O)c1ccc(cc1)[N+](=O)[O-] 6276200.0 923000.0 1.01 4845200.0 -210000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N16 mock treatment 4892840.0 -133624.24242424 -0.147749707401373 -0.2237 -0.5205 5480240.0 127000.0 0.14 4677360.0 -378000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N17 mock treatment 4925440.0 -101024.24242424 -0.111703550103115 -0.674 -0.841 5045120.0 -308000.0 -0.34 4339120.0 -716000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N18 mock treatment 4699280.0 -327184.24242424 -0.361771002083915 -0.1559 -0.2573 5705960.0 353000.0 0.39 4761400.0 -293000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N19 mock treatment 4728680.0 -297784.24242424 -0.329263117894689 -0.6084 -0.9958 5053960.0 -299000.0 -0.33 4659520.0 -395000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N20 mock treatment 4690000.0 -336464.24242424 -0.372031994100107 -0.5499 -0.9409 4967840.0 -385000.0 -0.42 4896960.0 -158000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N21 mock treatment 4542240.0 -484224.24242424 -0.535411754909636 -0.6279 -0.9467 5119840.0 -233000.0 -0.26 4759360.0 -296000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N22 mock treatment 4767800.0 -258664.24242424 -0.286007729136779 -0.8744 -0.956 4784200.0 -569000.0 -0.62 4451680.0 -603000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N23 mock treatment 4275560.0 -750904.24242424 -0.830282590133548 -1.1096 -0.8766 4491200.0 -862000.0 -0.94 4907800.0 -147000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 N24 mock treatment 4436960.0 -589504.24242424 -0.651820940196772 -1.04 -0.965 5006120.0 -347000.0 -0.38 4288160.0 -767000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O01 compound treatment 4062560.0 -963904.24242424 -1.06579889395346 -2.0423 -0.9841 3092791 BCB02_000223 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccc(Br)cc5 4003920.0 -1350000.0 -1.48 4064400.0 -990000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O02 compound treatment 4374800.0 -651664.24242424 -0.720551895339708 -1.8185 -0.928 3001177 BCB02_000224 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccco3 3851040.0 -1500000.0 -1.65 4273600.0 -781000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O03 compound treatment 4465520.0 -560944.24242424 -0.620241852698666 -0.9953 -0.996 3092792 BCB02_000225 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(OC)c(OCc5ccccc5)c4)C(=O)N(C6CCCCC6)C3=O)cc1 4894480.0 -459000.0 -0.5 4455640.0 -599000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O04 compound treatment 5689960.0 663495.75757576 0.733634124058371 -0.1123 -0.1134 3001178 BCB02_000226 CCOC(=O)C1=CC[C@H](N([C@@H]1C#N)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 5001960.0 -351000.0 -0.38 4513280.0 -542000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O05 compound treatment 5128160.0 101695.75757576 0.11244605135403 -0.5853 -0.6984 3092860 BCB02_000227 COc1ccc(NN2C3C(C=CC2C(O)c4ccccn4)C(=O)N(C5CCCCC5)C3=O)cc1 4686920.0 -666000.0 -0.73 4659680.0 -395000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O06 compound treatment 4027280.0 -999184.24242424 -1.10480835498053 -1.9638 -0.9992 3001179 BCB02_000228 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)CC[Si](C)(C)C)c2ccccc2 4349520.0 -1000000.0 -1.1 3861600.0 -1190000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O07 compound treatment 4714320.0 -312144.24242424 -0.345141118471467 -0.4996 -0.974 3092861 BCB02_000229 CCOc1cc(ccc1O)C(O)C2C=CC3C(N2Nc4ccc(OC)cc4)C(=O)N(C5CCCCC5)C3=O 5055480.0 -298000.0 -0.33 4861320.0 -194000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O08 compound treatment 3211360.0 -1815104.24242424 -2.00697954095583 -2.0369 -0.8933 3001245 BCB02_000230 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccn3C(=O)OC(C)(C)C 4580440.0 -773000.0 -0.85 4382560.0 -672000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O09 compound treatment 4429120.0 -597344.24242424 -0.660489709313899 -1.5954 -0.9785 3092862 BCB02_000231 COc1ccc(NN2C3C(C=CC2C(O)c4cc(cc(c4)C(F)(F)F)C(F)(F)F)C(=O)N(C5CCCCC5)C3=O)cc1 4325160.0 -1030000.0 -1.13 4081320.0 -974000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O10 compound treatment 2788440.0 -2238024.24242424 -2.47460656072821 -2.1575 -0.8162 3001246 BCB02_000232 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(C#N)cc3 4944560.0 -409000.0 -0.45 4242960.0 -812000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O11 compound treatment 5047000.0 20535.7575757597 0.0227065996262188 -0.5526 -0.7902 3092863 BCB02_000233 Cc1ccc(NN2C3C(C=CC2C(O)c4c(F)cccc4Cl)C(=O)N(C5CCCCC5)C3=O)cc1 4846360.0 -507000.0 -0.56 4631520.0 -423000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O12 compound treatment 4498400.0 -528064.24242424 -0.583886096503367 -0.5553 -0.8568 3001247 BCB02_000234 CCOC(=O)C1=CCC(NC1)c2cc3ccccc3[nH]2 5123880.0 -229000.0 -0.25 4928520.0 -126000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O13 compound treatment 4807760.0 -218704.24242424 -0.241823543687748 -0.59 -0.899 3092864 BCB02_000235 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccccc5 5165320.0 -188000.0 -0.21 4482640.0 -572000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O14 compound treatment 3893960.0 -1132504.24242424 -1.25222165838555 -1.9874 -0.9939 3001248 BCB02_000236 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccccc2[N+](=O)[O-])c3cc4ccccc4[nH]3 4469640.0 -884000.0 -0.97 3836760.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O15 compound treatment 4802560.0 -223904.24242424 -0.247573237489924 -0.8348 -0.9264 3092865 BCB02_000237 CCC(CC)C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4 4922880.0 -430000.0 -0.47 4330400.0 -724000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O16 mock treatment 4984080.0 -42384.2424242403 -0.0468646953801129 -0.2018 -0.5344 5016360.0 -337000.0 -0.37 5120800.0 65900.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O17 mock treatment 4942160.0 -84304.2424242403 -0.0932160731084254 -0.4929 -0.824 4847800.0 -505000.0 -0.55 4848520.0 -206000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O18 mock treatment 4762880.0 -263584.24242424 -0.291447824041915 -0.2833 -0.8453 5318240.0 -34900.0 -0.04 4894520.0 -160000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O19 mock treatment 5185160.0 158695.75757576 0.175471541108653 -0.5096 -0.6461 4755480.0 -598000.0 -0.65 4652760.0 -402000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O20 mock treatment 4828280.0 -198184.24242424 -0.219134367376084 -0.784 -0.9089 4692280.0 -661000.0 -0.72 4641320.0 -414000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O21 mock treatment 4523200.0 -503264.24242424 -0.556464479908373 -1.2722 -0.9632 4420320.0 -933000.0 -1.02 4431680.0 -623000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O22 mock treatment 4651520.0 -374944.24242424 -0.41457972823621 -1.2526 -0.9552 4494760.0 -858000.0 -0.94 4242920.0 -812000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O23 mock treatment 4138560.0 -887904.24242424 -0.981764907613958 -1.6326 -0.9778 4286360.0 -1070000.0 -1.17 4379560.0 -675000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 O24 mock treatment 4018120.0 -1008344.24242424 -1.11493666175513 -2.2336 -0.9923 3979520.0 -1370000.0 -1.5 3809840.0 -1250000.0 -1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P01 compound treatment 3716720.0 -1309744.24242424 -1.44819776021203 -2.5342 -0.9662 3001249 BCB02_000238 CC(C)OC(=O)CC(=O)CC(O)c1cccc(c1)[N+](=O)[O-] 3573800.0 -1780000.0 -1.95 4065920.0 -989000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P02 compound treatment 4158720.0 -867744.24242424 -0.95947378702706 -1.4222 -0.9922 3092866 BCB02_000239 CC[C@@H]1[C@H]2[C@@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)CC5C2C(=O)N(CC)C5=O 4703640.0 -650000.0 -0.71 4265160.0 -790000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P03 compound treatment 4304520.0 -721944.24242424 -0.798261218496813 -1.0189 -0.854 3001250 BCB02_000240 CC(C)OC(=O)CC(=O)CC(O)c1cccc(C#N)c1 5276720.0 -76400.0 -0.08 4175200.0 -880000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P04 compound treatment 3146960.0 -1879504.24242424 -2.07818728727509 -3.4287 -0.9711 3092867 BCB02_000241 CCOC(=O)C1=CC[C@H](N([C@H]1CC)S(=O)(=O)c2ccc(C)cc2)c3ccc(OC)cc3 3052240.0 -2300000.0 -2.52 3718920.0 -1340000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P05 compound treatment 4099160.0 -927304.24242424 -1.02532989526891 -0.6012 -0.5505 3001251 BCB02_000242 CC(C)OC(=O)CC(=O)CC(O)c1ccc(C#N)cc1 5588600.0 235000.0 0.26 4782040.0 -273000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P06 compound treatment 3866280.0 -1160184.24242424 -1.28282772077868 -1.572 -0.9095 3092868 BCB02_000243 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3Cl 5052320.0 -301000.0 -0.33 3948440.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P07 compound treatment 4134400.0 -892064.24242424 -0.986364662655699 -1.177 -0.925 3001252 BCB02_000244 COC(=O)C1=CCC(CC1)(C=C)C(=O)OC 5069320.0 -284000.0 -0.31 4316040.0 -739000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P08 compound treatment 3372040.0 -1654424.24242424 -1.82931400246859 -2.6693 -0.9655 3092869 BCB02_000245 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccc(Cl)c3 3672520.0 -1680000.0 -1.84 4104720.0 -950000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P09 compound treatment 3603320.0 -1423144.24242424 -1.57358531351334 -1.9344 -0.8455 3001253 BCB02_000246 COC(=O)/C=C(/CC(O)c1cccc(Cl)c1)\OC 3840440.0 -1510000.0 -1.66 4935000.0 -120000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P10 compound treatment 4089840.0 -936624.24242424 -1.03563511569896 -2.2148 -0.9777 3092870 BCB02_000247 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3C(F)(F)F 3835080.0 -1520000.0 -1.66 3921000.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P11 compound treatment 4296560.0 -729904.24242424 -0.807062672855528 -1.4054 -0.999 3001254 BCB02_000248 OC(C/C(=C/C(=O)OCCF)/OCCF)c1cccc(Cl)c1 4569680.0 -783000.0 -0.86 4288520.0 -766000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P12 compound treatment 3919640.0 -1106824.24242424 -1.22382701668557 -2.2011 -0.9947 3092871 BCB02_000249 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(Br)c2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OCC=C)cc4 4028720.0 -1320000.0 -1.45 3920800.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P13 compound treatment 3829400.0 -1197064.24242424 -1.32360631836026 -1.9084 -0.9665 3001255 BCB02_000250 CCO/C(=C\C(=O)OC)/CC(O)c1cccc(Cl)c1 4171920.0 -1180000.0 -1.29 4369040.0 -686000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P14 compound treatment 4052280.0 -974184.24242424 -1.07716559631622 -1.5191 -0.9656 3092774 BCB02_000251 CC[C@@H]1C(Sc2ccccc2)C([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 4432120.0 -921000.0 -1.01 4511440.0 -543000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P15 compound treatment 4354720.0 -671744.24242424 -0.742754559098881 -1.5793 -0.987 3092872 BCB02_000252 FCCOC(=O)C1=CCC(O1)c2cccc(Cl)c2 4541600.0 -812000.0 -0.89 3954960.0 -1100000.0 -1.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P16 mock treatment 4377920.0 -648544.24242424 -0.717102079058403 -1.6815 -0.9663 4142720.0 -1210000.0 -1.33 4188320.0 -867000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P17 mock treatment 4303360.0 -723104.24242424 -0.799543842498836 -1.3426 -0.9594 4402320.0 -951000.0 -1.04 4571920.0 -483000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P18 mock treatment 4510920.0 -515544.24242424 -0.570042602964281 -1.394 -0.9755 4429160.0 -924000.0 -1.01 4225280.0 -830000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P19 mock treatment 4108480.0 -917984.24242424 -1.01502467483885 -1.8222 -0.9795 4135280.0 -1220000.0 -1.33 4250320.0 -805000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P20 mock treatment 4181720.0 -844744.24242424 -0.934042449055896 -1.5151 -0.9966 4648080.0 -705000.0 -0.77 4140120.0 -915000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P21 mock treatment 4155880.0 -870584.24242424 -0.962614004411325 -1.941 -0.9918 4155040.0 -1200000.0 -1.31 3971640.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P22 mock treatment 4184880.0 -841584.24242424 -0.930548404360727 -2.3312 -0.9709 4107440.0 -1250000.0 -1.36 3318200.0 -1740000.0 -1.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P23 mock treatment 3736200.0 -1290264.24242424 -1.42665852266081 -2.9738 -0.9635 3171000.0 -2180000.0 -2.39 3725200.0 -1330000.0 -1.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2088 P24 mock treatment 4020960.0 -1005504.24242424 -1.11179644437087 -2.6073 -0.9749 3573800.0 -1780000.0 -1.95 3604560.0 -1450000.0 -1.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A01 compound treatment 1416880.0 -2808687.61904762 -3.10559496067059 -6.5598 -0.9911 3186889 PK04_093001 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1582880.0 -3950000.0 -4.33 1513040.0 -3910000.0 -3.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A02 compound treatment 1358680.0 -2866887.61904762 -3.1699473028411 -6.5996 -0.9924 3067555 PK04_093002 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1615280.0 -3920000.0 -4.3 1473240.0 -3950000.0 -3.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A03 compound treatment 3334320.0 -891247.61904762 -0.985461713738918 -3.6394 -0.9059 3186890 PK04_093003 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 2455160.0 -3080000.0 -3.38 3488880.0 -1940000.0 -1.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A04 compound treatment 3271480.0 -954087.61904762 -1.05494455191752 -3.0217 -0.9538 3186891 PK04_093004 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 3913360.0 -1620000.0 -1.78 3033000.0 -2390000.0 -2.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A05 compound treatment 2274560.0 -1951007.61904762 -2.15724931062242 -4.2877 -0.9956 3067558 PK04_093005 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 3063000.0 -2470000.0 -2.71 2874280.0 -2550000.0 -2.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A06 compound treatment 2443000.0 -1782567.61904762 -1.97100345984578 -3.1685 -0.9984 3186892 PK04_093006 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 3956320.0 -1580000.0 -1.73 3645560.0 -1780000.0 -1.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A07 compound treatment 1888280.0 -2337287.61904762 -2.58436310329639 -5.5893 -0.9878 3067559 PK04_093007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 2043840.0 -3490000.0 -3.83 2165680.0 -3260000.0 -3.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A08 compound treatment 3472280.0 -753287.61904762 -0.832917914325797 -2.3916 -0.9509 3186893 PK04_093008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 3772080.0 -1770000.0 -1.93 4053480.0 -1370000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A09 compound treatment 3367520.0 -858047.61904762 -0.948752130232716 -1.9812 -0.954 3186894 PK04_093009 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 4032640.0 -1510000.0 -1.65 4592760.0 -832000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A10 compound treatment 2106880.0 -2118687.61904762 -2.34265482153567 -4.9674 -0.988 3067560 PK04_093010 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 2399240.0 -3140000.0 -3.44 2610400.0 -2810000.0 -2.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A11 compound treatment 2885760.0 -1339807.61904762 -1.48143914679741 -3.0012 -0.9948 3186895 PK04_093011 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 3839440.0 -1700000.0 -1.86 3574080.0 -1850000.0 -1.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A12 compound treatment 2459760.0 -1765807.61904762 -1.95247175443722 -3.8031 -0.9952 3186896 PK04_093012 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 3274760.0 -2260000.0 -2.48 3275560.0 -2150000.0 -2.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A13 mock treatment 3649160.0 -576407.61904762 -0.637339868224082 -1.7636 -0.9237 4070280.0 -1470000.0 -1.61 4617040.0 -807000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A14 mock treatment 3324280.0 -901287.61904762 -0.996563045618504 -1.9194 -0.9969 4431040.0 -1110000.0 -1.21 4312360.0 -1110000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A15 compound treatment 1762680.0 -2462887.61904762 -2.72324032282587 -5.7339 -0.991 3067562 PK04_093013 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2058640.0 -3480000.0 -3.81 2038400.0 -3390000.0 -3.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A16 compound treatment 2052280.0 -2173287.61904762 -2.40302660645852 -5.2232 -0.9897 3186897 PK04_093014 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 2445040.0 -3090000.0 -3.39 2179000.0 -3250000.0 -3.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A17 compound treatment 3548600.0 -676967.61904762 -0.748530100675396 -1.8576 -0.9509 3067564 PK04_093015 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4116000.0 -1420000.0 -1.56 4515680.0 -909000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A18 compound treatment 2151280.0 -2074287.61904762 -2.29356128214786 -4.8856 -0.9909 3186898 PK04_093016 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 2620680.0 -2920000.0 -3.19 2460920.0 -2960000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A19 compound treatment 1667680.0 -2557887.61904762 -2.82828280575024 -5.8912 -0.9924 3186899 PK04_093017 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2034720.0 -3500000.0 -3.84 1897600.0 -3530000.0 -3.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A20 compound treatment 1478640.0 -2746927.61904762 -3.03730628966628 -6.3129 -0.9928 3067604 PK04_093018 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1820160.0 -3720000.0 -4.07 1612240.0 -3810000.0 -3.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A21 compound treatment 2166080.0 -2059487.61904762 -2.27719676901859 -4.9187 -0.9849 3186900 PK04_093019 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 2350400.0 -3190000.0 -3.49 2682480.0 -2740000.0 -2.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A22 compound treatment 2773560.0 -1452007.61904762 -1.60549984768282 -3.3743 -0.979 3067607 PK04_093020 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 3238160.0 -2300000.0 -2.52 3709840.0 -1710000.0 -1.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A23 compound treatment 3479880.0 -745687.61904762 -0.824514515691848 -2.0195 -0.9524 3186901 PK04_093021 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 3999040.0 -1540000.0 -1.69 4439560.0 -985000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 A24 compound treatment 2878720.0 -1346847.61904762 -1.48922334763728 -3.5203 -0.9633 3186902 PK04_093022 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3898760.0 -1640000.0 -1.79 2621200.0 -2800000.0 -2.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B01 compound treatment 2386280.0 -1839287.61904762 -2.03371935070336 -4.2747 -0.9923 3067612 PK04_093023 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 3075160.0 -2460000.0 -2.7 2760520.0 -2660000.0 -2.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B02 compound treatment 2603560.0 -1622007.61904762 -1.79347060660012 -3.4629 -0.997 3186903 PK04_093024 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3560360.0 -1980000.0 -2.17 3392680.0 -2030000.0 -2.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B03 compound treatment 3592600.0 -632967.61904762 -0.699878845426213 -2.864 -0.9176 3067614 PK04_093025 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 3321920.0 -2220000.0 -2.43 3596760.0 -1830000.0 -1.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B04 compound treatment 1482160.0 -2743407.61904762 -3.03341418924634 -6.1955 -0.9926 3186904 PK04_093026 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1790120.0 -3750000.0 -4.1 1843720.0 -3580000.0 -3.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B05 compound treatment 2237480.0 -1988087.61904762 -2.19824905027332 -4.6029 -0.9923 3186905 PK04_093027 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 2976320.0 -2560000.0 -2.81 2465800.0 -2960000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B06 compound treatment 3845800.0 -379767.61904762 -0.419912985674097 -1.1052 -0.9662 3068180 PK04_093028 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4936080.0 -602000.0 -0.66 4591920.0 -833000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B07 compound treatment 3274520.0 -951047.61904762 -1.05158319246394 -2.3653 -0.9758 3186906 PK04_093029 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4382840.0 -1150000.0 -1.26 3650200.0 -1770000.0 -1.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B08 compound treatment 1527960.0 -2697607.61904762 -2.98277265537333 -5.6586 -0.9973 3186992 PK04_093030 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2279160.0 -3260000.0 -3.57 2186360.0 -3240000.0 -3.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B09 compound treatment 2346800.0 -1878767.61904762 -2.07737279518604 -3.7703 -0.9987 3068181 PK04_093031 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 3410840.0 -2130000.0 -2.33 3308120.0 -2120000.0 -2.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B10 compound treatment 2922640.0 -1302927.61904762 -1.44066054921582 -3.3952 -0.9829 3186993 PK04_093032 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 3517720.0 -2020000.0 -2.21 3204480.0 -2220000.0 -2.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B11 compound treatment 1641280.0 -2584287.61904762 -2.85747355889975 -5.7333 -0.9923 3068182 PK04_093033 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2015040.0 -3520000.0 -3.86 2220680.0 -3200000.0 -3.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B12 compound treatment 3255040.0 -970527.61904762 -1.07312243001517 -1.8499 -0.9676 3186994 PK04_093034 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 4876640.0 -661000.0 -0.72 4022440.0 -1400000.0 -1.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B13 mock treatment 3836960.0 -388607.61904762 -0.429687465137796 -0.9032 -0.9757 4910520.0 -627000.0 -0.69 4978160.0 -446000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B14 mock treatment 3712160.0 -513407.61904762 -0.567680116390024 -0.6672 -0.9325 5352920.0 -185000.0 -0.2 5040280.0 -384000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B15 compound treatment 3460480.0 -765087.61904762 -0.845965296415351 -0.8167 -0.8654 3068183 PK04_093035 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)O 5203640.0 -334000.0 -0.37 5222400.0 -202000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B16 compound treatment 3604600.0 -620967.61904762 -0.686610321267345 -1.7438 -0.974 3186995 PK04_093036 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 4538280.0 -999000.0 -1.09 4189640.0 -1230000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B17 compound treatment 932000.0 -3293567.61904762 -3.64173179351658 -6.7115 -0.999 3186996 PK04_093037 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1833560.0 -3700000.0 -4.06 1512000.0 -3910000.0 -3.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B18 compound treatment 3766200.0 -459367.61904762 -0.507927529261255 -0.4931 -0.8595 3068184 PK04_093038 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 5448080.0 -89600.0 -0.1 5177240.0 -247000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B19 compound treatment 1797040.0 -2428527.61904762 -2.68524811531765 -5.6802 -0.9863 3186997 PK04_093039 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1876840.0 -3660000.0 -4.01 2291520.0 -3130000.0 -3.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B20 compound treatment 2511280.0 -1714287.61904762 -1.89550555738182 -3.4711 -0.9893 3186998 PK04_093040 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 3338200.0 -2200000.0 -2.41 3722560.0 -1700000.0 -1.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B21 compound treatment 3244800.0 -980767.61904762 -1.08444490396407 -2.0057 -0.9935 3068185 PK04_093041 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 4583280.0 -954000.0 -1.05 4084960.0 -1340000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B22 compound treatment 3442160.0 -783407.61904762 -0.866221909964556 -1.597 -0.9893 3186999 PK04_093042 CN(C)C(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 4524960.0 -1010000.0 -1.11 4636360.0 -788000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B23 compound treatment 3535240.0 -690327.61904762 -0.763302390905603 -1.3184 -0.9854 3068186 PK04_093043 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)O 4696440.0 -841000.0 -0.92 4827600.0 -597000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 B24 compound treatment 2814040.0 -1411527.61904762 -1.56074069285357 -3.1926 -0.9933 3187000 PK04_093044 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 3813840.0 -1720000.0 -1.89 3350640.0 -2070000.0 -2.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C01 compound treatment 1642360.0 -2583207.61904762 -2.85627939172545 -6.2226 -0.9893 3187001 PK04_093045 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1811200.0 -3730000.0 -4.08 1597560.0 -3830000.0 -3.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C02 compound treatment 3184080.0 -1041487.61904762 -1.15158363620795 -2.7847 -0.9738 3068187 PK04_093046 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 3646040.0 -1890000.0 -2.07 3830000.0 -1590000.0 -1.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C03 compound treatment 3587600.0 -637967.61904762 -0.705407397159075 -1.5856 -0.8564 3187002 PK04_093047 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4011520.0 -1530000.0 -1.67 5056200.0 -368000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C04 compound treatment 4042600.0 -182967.61904762 -0.20230918946866 -0.6517 -0.9285 3068188 PK04_093048 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 5211520.0 -326000.0 -0.36 4857160.0 -567000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C05 compound treatment 3643600.0 -581967.61904762 -0.643487617751024 -0.9756 -0.8734 3187003 PK04_093049 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 5405480.0 -132000.0 -0.14 4526160.0 -898000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C06 compound treatment 3435160.0 -790407.61904762 -0.873961882390563 -1.4331 -0.9961 3187004 PK04_093050 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 4729640.0 -808000.0 -0.88 4703640.0 -721000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C07 compound treatment 3663520.0 -562047.61904762 -0.621461867647303 -0.6851 -0.8165 3068189 PK04_093051 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 5022800.0 -515000.0 -0.56 5423040.0 -1390.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C08 compound treatment 3524440.0 -701127.61904762 -0.775244062648584 -0.6047 -0.7382 3187005 PK04_093052 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 5295960.0 -242000.0 -0.26 5417000.0 -7430.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C09 compound treatment 2927600.0 -1297967.61904762 -1.43517622589682 -1.6397 -0.9394 3187006 PK04_093053 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 4885720.0 -652000.0 -0.71 4736000.0 -688000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C10 compound treatment 1495720.0 -2729847.61904762 -3.01842075694682 -5.7303 -0.997 3068190 PK04_093054 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 2207840.0 -3330000.0 -3.65 2175800.0 -3250000.0 -3.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C11 mock treatment 3880280.0 -345287.61904762 -0.381788092924283 -0.3835 -0.8627 5479320.0 -58400.0 -0.06 5206640.0 -218000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C12 mock treatment 3815760.0 -409807.61904762 -0.45312852448513 -0.2918 -0.6155 5427160.0 -111000.0 -0.12 5492960.0 68500.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C13 compound treatment 1834920.0 -2390647.61904762 -2.64336380738949 -5.5982 -0.9911 3187007 PK04_093055 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2180200.0 -3360000.0 -3.68 2060240.0 -3360000.0 -3.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C14 compound treatment 3159960.0 -1065607.61904762 -1.17825336976727 -2.1088 -0.9956 3068191 PK04_093056 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 4532440.0 -1010000.0 -1.1 4055840.0 -1370000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C15 mock treatment 4057960.0 -167607.61904762 -0.185325478545309 -0.0864 -0.4068 5488880.0 -48800.0 -0.05 5513200.0 88800.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C16 mock treatment 4204280.0 -21287.6190476203 -0.0235379406348442 -0.4993 -0.8357 5120800.0 -417000.0 -0.46 5041000.0 -383000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C17 compound treatment 1987160.0 -2238407.61904762 -2.47503046422731 -5.0364 -0.974 3187008 PK04_093057 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2011160.0 -3530000.0 -3.86 3046560.0 -2380000.0 -2.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C18 compound treatment 3096360.0 -1129207.61904762 -1.24857654780927 -1.9604 -0.9919 3068193 PK04_093058 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4690840.0 -847000.0 -0.93 4209240.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C19 compound treatment 2760040.0 -1465527.61904762 -1.62044905156848 -3.5176 -0.986 3187009 PK04_093059 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 3291200.0 -2250000.0 -2.46 3419640.0 -2000000.0 -2.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C20 compound treatment 3095920.0 -1129647.61904762 -1.24906306036176 -2.6684 -0.9679 3187010 PK04_093060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 4381640.0 -1160000.0 -1.27 3325280.0 -2100000.0 -2.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C21 compound treatment 3165320.0 -1060247.61904762 -1.17232676230964 -2.3359 -0.981 3068197 PK04_093061 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 4489480.0 -1050000.0 -1.15 3704920.0 -1720000.0 -1.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C22 compound treatment 3109400.0 -1116167.61904762 -1.23415808488997 -2.0285 -0.995 3187011 PK04_093062 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 4619040.0 -919000.0 -1.01 4155640.0 -1270000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C23 compound treatment 3679840.0 -545727.61904762 -0.603416674791243 -0.9482 -0.9491 3068199 PK04_093063 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 5261640.0 -276000.0 -0.3 4690400.0 -734000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 C24 compound treatment 3038600.0 -1186967.61904762 -1.31244237742729 -3.8078 -0.9615 3187012 PK04_093064 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCCCC3 3183000.0 -2350000.0 -2.58 2729840.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D01 compound treatment 2809160.0 -1416407.61904762 -1.56613655934485 -2.1718 -0.9848 3187091 PK04_093065 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 4518360.0 -1020000.0 -1.12 4349080.0 -1080000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D02 compound treatment 3649160.0 -576407.61904762 -0.637339868224082 -1.2033 -0.8554 3068202 PK04_093066 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4408880.0 -1130000.0 -1.24 5214600.0 -210000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D03 compound treatment 4079480.0 -146087.61904762 -0.161530591887072 -0.4505 -0.9618 3187092 PK04_093067 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 5282960.0 -255000.0 -0.28 5085760.0 -339000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D04 compound treatment 1512240.0 -2713327.61904762 -3.00015442202145 -5.9278 -0.9961 3187093 PK04_093068 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 2166920.0 -3370000.0 -3.69 1861520.0 -3560000.0 -3.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D05 compound treatment 1753120.0 -2472447.61904762 -2.7338109137391 -5.2517 -0.995 3068220 PK04_093069 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2877320.0 -2660000.0 -2.91 1987800.0 -3440000.0 -3.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D06 compound treatment 1964720.0 -2260847.61904762 -2.4998426044044 -5.0278 -0.9947 3187094 PK04_093070 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 2806520.0 -2730000.0 -2.99 2218360.0 -3210000.0 -3.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D07 compound treatment 4164480.0 -61087.6190476203 -0.0675452124284234 -0.3464 -0.8955 3068223 PK04_093071 COC(=O)[C@H]1COC(=N1)c2ccc(OCCCO)cc2 5257280.0 -280000.0 -0.31 5199840.0 -225000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D08 compound treatment 1488160.0 -2737407.61904762 -3.02677992716691 -5.9373 -0.9966 3187095 PK04_093072 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 2222040.0 -3320000.0 -3.63 1811480.0 -3610000.0 -3.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D09 compound treatment 1404520.0 -2821047.61904762 -3.11926154055422 -6.1401 -0.9862 3068225 PK04_093073 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1531320.0 -4010000.0 -4.39 2307240.0 -3120000.0 -3.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D10 compound treatment 4280280.0 54712.3809523797 0.0604960457046536 -0.101 -0.5686 3187096 PK04_093074 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 5421560.0 -116000.0 -0.13 5316520.0 -108000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D11 mock treatment 4046160.0 -179407.61904762 -0.198372860634863 -0.3417 -0.8501 5221400.0 -316000.0 -0.35 5377520.0 -46900.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D12 mock treatment 3896280.0 -329287.61904762 -0.364096727379125 -0.0369 -0.0727 5857800.0 320000.0 0.35 5374200.0 -50200.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D13 compound treatment 1918400.0 -2307167.61904762 -2.55105910765763 -5.3043 -0.9918 3187097 PK04_093075 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 2328040.0 -3210000.0 -3.51 2314280.0 -3110000.0 -3.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D14 compound treatment 2890320.0 -1335247.61904762 -1.47639710761704 -3.3494 -0.9854 3068228 PK04_093076 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 3468600.0 -2070000.0 -2.27 3372720.0 -2050000.0 -2.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D15 mock treatment 4013200.0 -212367.61904762 -0.234817073657887 -0.4264 -0.8171 5501720.0 -36000.0 -0.04 4961720.0 -463000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D16 mock treatment 4219320.0 -6247.61904762033 -0.00690805702239623 0.01 0.0662 5452200.0 -85500.0 -0.09 5541800.0 117000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D17 compound treatment 3509760.0 -715807.61904762 -0.791475890536266 -1.7281 -0.9851 3187098 PK04_093077 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 4425560.0 -1110000.0 -1.22 4444240.0 -980000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D18 compound treatment 3764480.0 -461087.61904762 -0.50982935105736 -1.1169 -0.9735 3187099 PK04_093078 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 5018520.0 -519000.0 -0.57 4571280.0 -853000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D19 compound treatment 3956080.0 -269487.61904762 -0.297975248654099 -1.0123 -0.9435 3068229 PK04_093079 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 4910680.0 -627000.0 -0.69 4658360.0 -766000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D20 compound treatment 3388480.0 -837087.61904762 -0.92557644136856 -2.0112 -0.988 3187100 PK04_093080 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 4290200.0 -1250000.0 -1.37 4236920.0 -1190000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D21 compound treatment 2261200.0 -1964367.61904762 -2.17202160085263 -3.7804 -0.9297 3068232 PK04_093081 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 2573120.0 -2960000.0 -3.25 4299200.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D22 compound treatment 4031520.0 -194047.61904762 -0.214560460108682 -0.4104 -0.9894 3187101 PK04_093082 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCC(O)CO 5345760.0 -192000.0 -0.21 5139320.0 -285000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D23 compound treatment 2660560.0 -1565007.61904762 -1.7304451168455 -3.0125 -0.943 3187102 PK04_093083 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 3259240.0 -2280000.0 -2.5 4435720.0 -989000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 D24 compound treatment 3273040.0 -952527.61904762 -1.05321964377687 -2.0106 -0.9829 3068234 PK04_093084 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 4201000.0 -1340000.0 -1.46 4462480.0 -962000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E01 mock treatment 3804280.0 -421287.61904762 -0.46582207926378 -1.1548 -0.9702 4934560.0 -603000.0 -0.66 4553760.0 -871000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E02 mock treatment 3939720.0 -285847.61904762 -0.316064669924023 -0.8537 -0.9446 5137920.0 -400000.0 -0.44 4702240.0 -722000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E03 compound treatment 3493680.0 -731887.61904762 -0.809255712909149 -1.7268 -0.9862 3187103 PK04_093085 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4427840.0 -1110000.0 -1.22 4461560.0 -963000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E04 compound treatment 2035600.0 -2189967.61904762 -2.42146985503935 -4.6329 -0.9947 3187104 PK04_093086 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 3214400.0 -2320000.0 -2.54 2376640.0 -3050000.0 -3.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E05 compound treatment 4027880.0 -197687.61904762 -0.218585245770205 -0.5134 -0.98 3068237 PK04_093087 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 5204280.0 -333000.0 -0.37 5119960.0 -304000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E06 compound treatment 4308640.0 83072.3809523797 0.0918539911334452 0.2505 0.3077 3187105 PK04_093088 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCC(O)CO 6192160.0 654000.0 0.72 5051000.0 -373000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E07 compound treatment 878160.0 -3347407.61904762 -3.70126323857604 -6.8198 -0.9984 3068240 PK04_093089 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2002400.0 -3540000.0 -3.87 1200120.0 -4220000.0 -4.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E08 compound treatment 1752440.0 -2473127.61904762 -2.73456279677477 -5.155 -0.9979 3187106 PK04_093090 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2611240.0 -2930000.0 -3.2 2445800.0 -2980000.0 -2.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E09 mock treatment 3883080.0 -342487.61904762 -0.37869210395388 0.0572 0.093 5979560.0 442000.0 0.48 5418240.0 -6190.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E10 mock treatment 4350920.0 125352.38095238 0.138603424586524 0.5571 0.92 5864560.0 327000.0 0.36 5891120.0 467000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E11 compound treatment 3465920.0 -759647.61904762 -0.839950232129998 -1.7894 -0.9582 3068242 PK04_093091 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 4197000.0 -1340000.0 -1.47 4636080.0 -788000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E12 compound treatment 2878240.0 -1347327.61904762 -1.48975408860363 -2.4494 -0.9991 3187107 PK04_093092 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 4247960.0 -1290000.0 -1.41 4088960.0 -1340000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E13 compound treatment 1875400.0 -2350167.61904762 -2.59860465256024 -5.2187 -0.9829 3068264 PK04_093093 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 2057760.0 -3480000.0 -3.81 2804360.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E14 compound treatment 2334720.0 -1890847.61904762 -2.09072977617263 -4.5028 -0.9897 3187108 PK04_093094 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 2809920.0 -2730000.0 -2.99 2712960.0 -2710000.0 -2.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E15 compound treatment 2152160.0 -2073407.61904762 -2.29258825704288 -4.4602 -0.996 3187109 PK04_093095 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2924600.0 -2610000.0 -2.86 2862480.0 -2560000.0 -2.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E16 compound treatment 3306560.0 -919007.61904762 -1.01615623295977 -1.9369 -0.9602 3068267 PK04_093096 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 4824560.0 -713000.0 -0.78 3872200.0 -1550000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E17 mock treatment 4196480.0 -29087.6190476203 -0.0321624813381085 -0.1304 -0.6554 5358360.0 -179000.0 -0.2 5427040.0 2610.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E18 mock treatment 4423360.0 197792.38095238 0.218701082092224 0.1325 0.5953 5516120.0 -21600.0 -0.02 5458800.0 34400.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E19 compound treatment 3989640.0 -235927.61904762 -0.260867609423131 -0.0656 -0.228 3187110 PK04_093097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)O 5564320.0 26600.0 0.03 5542040.0 118000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E20 compound treatment 3035880.0 -1189687.61904762 -1.31544990956997 -2.4372 -0.9989 3187111 PK04_093098 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 4224200.0 -1310000.0 -1.44 3962200.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E21 compound treatment 3655600.0 -569967.61904762 -0.630219093592156 -1.3735 -0.9804 3068269 PK04_093099 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 4862480.0 -675000.0 -0.74 4418640.0 -1010000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E22 compound treatment 3290600.0 -934967.61904762 -1.03380337009106 -2.6344 -0.9723 3187184 PK04_093100 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 4063920.0 -1470000.0 -1.61 3516160.0 -1910000.0 -1.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E23 compound treatment 3346720.0 -878847.61904762 -0.971750905441421 -2.0002 -0.9935 3068272 PK04_093101 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 4369880.0 -1170000.0 -1.28 4214920.0 -1210000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 E24 compound treatment 1911640.0 -2313927.61904762 -2.55853370960046 -5.6244 -0.9868 3187185 PK04_093102 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 2013960.0 -3520000.0 -3.86 2111960.0 -3310000.0 -3.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F01 mock treatment 3925120.0 -300447.61904762 -0.332208040983979 -1.1047 -0.9325 4949400.0 -588000.0 -0.64 4490760.0 -934000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F02 mock treatment 3718880.0 -506687.61904762 -0.560249742861058 -1.0392 -0.9961 5022400.0 -515000.0 -0.56 4751520.0 -673000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F03 compound treatment 2472320.0 -1753247.61904762 -1.93858403248428 -4.4307 -0.9633 3068274 PK04_093103 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 2290360.0 -3250000.0 -3.56 3252720.0 -2170000.0 -2.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F04 compound treatment 1961880.0 -2263687.61904762 -2.50298282178866 -5.1406 -0.9932 3187186 PK04_093104 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 2744120.0 -2790000.0 -3.06 2094880.0 -3330000.0 -3.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F05 compound treatment 1527160.0 -2698407.61904762 -2.98365722365059 -5.5643 -0.9924 3068276 PK04_093105 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2905920.0 -2630000.0 -2.88 1666040.0 -3760000.0 -3.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F06 compound treatment 2890560.0 -1335007.61904762 -1.47613173713386 -2.4741 -0.9403 3187187 PK04_093106 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 4832000.0 -706000.0 -0.77 3395360.0 -2030000.0 -2.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F07 compound treatment 2403120.0 -1822447.61904762 -2.01509918846708 -4.0454 -0.9952 3187188 PK04_093107 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 3221520.0 -2320000.0 -2.54 2978000.0 -2450000.0 -2.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F08 compound treatment 2239000.0 -1986567.61904762 -2.19656837054653 -4.2314 -0.9918 3068278 PK04_093108 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 3486840.0 -2050000.0 -2.25 2548280.0 -2880000.0 -2.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F09 mock treatment 4539400.0 313832.38095238 0.347007710708479 0.0953 0.1845 5221880.0 -316000.0 -0.35 5587800.0 163000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F10 mock treatment 3922400.0 -303167.61904762 -0.335215573126656 -0.3372 -0.8506 5348280.0 -189000.0 -0.21 5383240.0 -41200.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F11 compound treatment 2216560.0 -2009007.61904762 -2.22138051072362 -4.6872 -0.9908 3187189 PK04_093109 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 2691120.0 -2850000.0 -3.12 2654600.0 -2770000.0 -2.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F12 compound treatment 4269640.0 44072.3809523797 0.0487312876171239 -0.1387 -0.6382 3068280 PK04_093110 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 5441720.0 -96000.0 -0.11 5241160.0 -183000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F13 compound treatment 2778880.0 -1446687.61904762 -1.59961746863906 -4.1139 -0.9592 3187190 PK04_093111 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2527640.0 -3010000.0 -3.3 3202880.0 -2220000.0 -2.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F14 compound treatment 2043080.0 -2182487.61904762 -2.41319914164699 -4.6029 -0.9945 3187191 PK04_093112 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 2754520.0 -2780000.0 -3.05 2922000.0 -2500000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F15 compound treatment 1583480.0 -2642087.61904762 -2.92138361693163 -5.9757 -0.9934 3068282 PK04_093113 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1991080.0 -3550000.0 -3.88 1892120.0 -3530000.0 -3.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F16 compound treatment 2540480.0 -1685087.61904762 -1.8632188152619 -4.5271 -0.9741 3187192 PK04_093114 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 3137520.0 -2400000.0 -2.63 2086960.0 -3340000.0 -3.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F17 mock treatment 4020400.0 -205167.61904762 -0.226855959162566 -0.1189 -0.5213 5536000.0 -1690.0 0.0 5447160.0 22700.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F18 mock treatment 4195840.0 -29727.6190476203 -0.0328701359599148 0.6167 0.7722 6153320.0 616000.0 0.67 5849720.0 425000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F19 compound treatment 1834480.0 -2391087.61904762 -2.64385031994198 -5.1815 -0.996 3187193 PK04_093115 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 2530240.0 -3010000.0 -3.29 2398000.0 -3030000.0 -3.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F20 compound treatment 4238800.0 13232.3809523797 0.014631180528833 0.2768 0.7831 3068312 PK04_093116 NC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 5666400.0 129000.0 0.14 5747040.0 323000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F21 compound treatment 3549040.0 -676527.61904762 -0.748043588122905 -0.9442 -0.9409 3068314 PK04_093117 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 5282120.0 -256000.0 -0.28 4819120.0 -605000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F22 compound treatment 3970280.0 -255287.61904762 -0.282274161732772 -0.3545 -0.6779 3187194 PK04_093118 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 5626760.0 89100.0 0.1 4996600.0 -428000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F23 compound treatment 2225120.0 -2000447.61904762 -2.21191563015696 -4.7025 -0.9886 3187195 PK04_093119 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 2593520.0 -2940000.0 -3.22 2725200.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 F24 compound treatment 3685520.0 -540047.61904762 -0.597136240022712 -1.523 -0.9749 3068317 PK04_093120 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 4630840.0 -907000.0 -0.99 4380520.0 -1040000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G01 compound treatment 3593880.0 -631687.61904762 -0.698463536182601 -1.8691 -0.964 3187196 PK04_093121 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 4236120.0 -1300000.0 -1.43 4314800.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G02 compound treatment 3794520.0 -431047.61904762 -0.476613812246326 -1.4932 -0.9253 3068319 PK04_093122 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCCCC3 4322880.0 -1210000.0 -1.33 4647840.0 -777000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G03 mock treatment 3841880.0 -383687.61904762 -0.42424737023266 -0.5366 -0.9634 5340360.0 -197000.0 -0.22 5136320.0 -288000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G04 mock treatment 3756120.0 -469447.61904762 -0.519073089554704 -0.0993 -0.1633 5826120.0 288000.0 0.32 5455440.0 31000.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G05 compound treatment 4154320.0 -71247.6190476203 -0.0787792295495984 -0.1824 -0.8087 3187197 PK04_093123 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 5512480.0 -25200.0 -0.03 5215640.0 -209000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G06 compound treatment 2522320.0 -1703247.61904762 -1.88329851515566 -2.8995 -0.9903 3187198 PK04_093124 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 3900080.0 -1640000.0 -1.79 4083800.0 -1340000.0 -1.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G07 compound treatment 4034880.0 -190687.61904762 -0.210845273344199 -0.0792 -0.3107 3068323 PK04_093125 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 5657440.0 120000.0 0.13 5367160.0 -57300.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G08 compound treatment 3676720.0 -548847.61904762 -0.606866491072548 -1.8755 -0.9359 3187199 PK04_093126 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 4074880.0 -1460000.0 -1.6 4388520.0 -1040000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G09 compound treatment 4296920.0 71352.3809523797 0.0788950658716174 -0.6986 -0.7258 3068325 PK04_093127 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 5142520.0 -395000.0 -0.43 4571360.0 -853000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G10 compound treatment 2827720.0 -1397847.61904762 -1.54561457531247 -3.1976 -0.9909 3187200 PK04_093128 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 3565920.0 -1970000.0 -2.16 3597560.0 -1830000.0 -1.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G11 compound treatment 4014280.0 -211287.61904762 -0.233622906483589 -0.4758 -0.9939 3187201 PK04_093129 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 5278880.0 -259000.0 -0.28 5118480.0 -306000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G12 compound treatment 1903840.0 -2321727.61904762 -2.56715825030372 -5.1576 -0.9951 3068327 PK04_093130 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 2574320.0 -2960000.0 -3.25 2314800.0 -3110000.0 -3.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G13 compound treatment 653840.0 -3571727.61904762 -3.94929618351914 -8.0384 -0.9942 3187202 PK04_093131 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 857720.0 -4680000.0 -5.13 593280.0 -4830000.0 -4.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G14 compound treatment 4673840.0 448272.38095238 0.495659409701664 0.8739 0.9429 3187203 PK04_093132 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 5803200.0 266000.0 0.29 6149000.0 725000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G15 compound treatment 4489880.0 264312.38095238 0.292252934346216 0.5404 0.9073 3068330 PK04_093133 COC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 5670640.0 133000.0 0.15 5920840.0 496000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G16 compound treatment 3044400.0 -1181167.61904762 -1.30602925741717 -3.4046 -0.973 3068332 PK04_093134 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 3450760.0 -2090000.0 -2.29 3127200.0 -2300000.0 -2.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G17 compound treatment 3914320.0 -311247.61904762 -0.34414971272696 -0.2322 -0.6064 3187278 PK04_093135 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 5616320.0 78600.0 0.09 5280800.0 -144000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G18 compound treatment 3129800.0 -1095767.61904762 -1.21160159381989 -3.0271 -0.9053 3187279 PK04_093136 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2884000.0 -2650000.0 -2.91 4303120.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G19 mock treatment 4251360.0 25792.3809523797 0.0285189024817816 0.1279 0.5925 5519400.0 -18300.0 -0.02 5636680.0 212000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G20 mock treatment 4723480.0 497912.38095238 0.550546871305515 0.2892 0.5008 5625280.0 87600.0 0.1 5279400.0 -145000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G21 compound treatment 4111440.0 -114127.61904762 -0.12619208921062 0.1146 0.4372 3187280 PK04_093137 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 5682080.0 144000.0 0.16 5590320.0 166000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G22 compound treatment 1931000.0 -2294567.61904762 -2.53712715729081 -5.27 -0.9912 3068361 PK04_093138 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2311680.0 -3230000.0 -3.53 2377480.0 -3050000.0 -3.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G23 compound treatment 3805320.0 -420247.61904762 -0.464672140503345 -0.1856 -0.2871 3187281 PK04_093139 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 5885960.0 348000.0 0.38 5187040.0 -237000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 G24 compound treatment 3347720.0 -877847.61904762 -0.970645195094848 -4.1709 -0.9206 3187282 PK04_093140 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2568920.0 -2970000.0 -3.25 2432680.0 -2990000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H01 compound treatment 2175560.0 -2050007.61904762 -2.26671463493308 -4.8528 -0.9894 3068365 PK04_093141 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 2556440.0 -2980000.0 -3.26 2560880.0 -2860000.0 -2.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H02 compound treatment 1959480.0 -2266087.61904762 -2.50563652662043 -4.9085 -0.9924 3187283 PK04_093142 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 2505440.0 -3030000.0 -3.32 2758520.0 -2670000.0 -2.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H03 mock treatment 3991000.0 -234567.61904762 -0.259363843351793 0.378 0.519 5817400.0 280000.0 0.31 6030040.0 606000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H04 mock treatment 4284200.0 58632.3809523797 0.0648304302632172 -0.02 -0.0394 5813640.0 276000.0 0.3 5024200.0 -400000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H05 compound treatment 2320240.0 -1905327.61904762 -2.106740461991 -3.9154 -0.9988 3068368 PK04_093143 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 3425440.0 -2110000.0 -2.31 3071160.0 -2350000.0 -2.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H06 compound treatment 4170320.0 -55247.6190476203 -0.0610878640044409 0.3551 0.7352 3187284 PK04_093144 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 5866400.0 329000.0 0.36 5739400.0 315000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H07 compound treatment 2077960.0 -2147607.61904762 -2.37463196475854 -4.1724 -0.9995 3187285 PK04_093145 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 3402840.0 -2130000.0 -2.34 2919120.0 -2510000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H08 compound treatment 4087880.0 -137687.61904762 -0.152242624975865 0.2536 0.41 3068370 PK04_093146 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 6085000.0 547000.0 0.6 5416560.0 -7870.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H09 compound treatment 2352600.0 -1872967.61904762 -2.07095967517592 -4.316 -0.9919 3187286 PK04_093147 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 2940640.0 -2600000.0 -2.84 2873120.0 -2550000.0 -2.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H10 compound treatment 2498320.0 -1727247.61904762 -1.90983556347339 -3.9142 -0.9916 3187287 PK04_093148 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3136080.0 -2400000.0 -2.63 3192680.0 -2230000.0 -2.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H11 compound treatment 3482080.0 -743487.61904762 -0.822081952929389 -1.6351 -0.9875 3068373 PK04_093149 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 4758400.0 -779000.0 -0.85 4271960.0 -1150000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H12 compound treatment 3909600.0 -315967.61904762 -0.349368665562782 -1.2951 -0.9046 3187288 PK04_093150 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCc3ccccc3 4436200.0 -1100000.0 -1.21 4739320.0 -685000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H13 compound treatment 3086040.0 -1139527.61904762 -1.2599874785859 -3.2341 -0.9439 3187289 PK04_093151 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 3005240.0 -2530000.0 -2.77 3861760.0 -1560000.0 -1.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H14 compound treatment 2220200.0 -2005367.61904762 -2.21735572506209 -5.385 -0.9768 3068375 PK04_093152 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 2001920.0 -3540000.0 -3.87 2198240.0 -3230000.0 -3.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H15 compound treatment 3682280.0 -543287.61904762 -0.600718741545606 -2.472 -0.901 3187290 PK04_093153 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CC=C)C3=O 3453040.0 -2080000.0 -2.28 4031520.0 -1390000.0 -1.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H16 compound treatment 4399440.0 173872.38095238 0.192252490602214 0.3831 0.9011 3187291 PK04_093154 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 5869640.0 332000.0 0.36 5531760.0 107000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H17 compound treatment 3765840.0 -459727.61904762 -0.508325584986021 -0.4289 -0.7613 3068378 PK04_093155 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 5545160.0 7470.0 0.01 5182560.0 -242000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H18 compound treatment 4720200.0 494632.38095238 0.546920141368758 0.8723 0.9982 3187292 PK04_093156 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCCN4CCOCC4 5976760.0 439000.0 0.48 5905840.0 481000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H19 mock treatment 4407240.0 181672.38095238 0.200877031305478 0.6857 0.8614 5777640.0 240000.0 0.26 6145920.0 721000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H20 mock treatment 4417760.0 192192.38095238 0.212509104151419 0.6857 0.93 6080760.0 543000.0 0.59 5803520.0 379000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H21 compound treatment 2297720.0 -1927847.61904762 -2.13164105899581 -4.5135 -0.9911 3187293 PK04_093157 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 2830760.0 -2710000.0 -2.96 2712520.0 -2710000.0 -2.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H22 compound treatment 3458560.0 -767007.61904762 -0.84808826028077 -2.4435 -0.9549 3068380 PK04_093158 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 3785600.0 -1750000.0 -1.92 3964280.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H23 compound treatment 2252280.0 -1973287.61904762 -2.18188453714405 -5.1217 -0.9799 3068402 PK04_093159 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 2207000.0 -3330000.0 -3.65 2393640.0 -3030000.0 -3.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 H24 compound treatment 2338600.0 -1886967.61904762 -2.08643962002793 -5.485 -0.9693 3187294 PK04_093160 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1875560.0 -3660000.0 -4.01 2033160.0 -3390000.0 -3.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I01 compound treatment 3631400.0 -594167.61904762 -0.656977283979207 -1.8429 -0.9653 3068406 PK04_093161 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 4367880.0 -1170000.0 -1.28 4175040.0 -1250000.0 -1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I02 compound treatment 3354480.0 -871087.61904762 -0.963170593152019 -3.8469 -0.8924 3187295 PK04_093162 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 2168320.0 -3370000.0 -3.69 3421600.0 -2000000.0 -2.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I03 compound treatment 3555840.0 -669727.61904762 -0.740524757766213 -1.5121 -0.9924 3068409 PK04_093163 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4740760.0 -797000.0 -0.87 4422160.0 -1000000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I04 compound treatment 4254240.0 28672.3809523797 0.0317033482799099 -0.1891 -0.2569 3187296 PK04_093164 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 5819240.0 282000.0 0.31 4759200.0 -665000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I05 mock treatment 3500560.0 -725007.61904762 -0.801648425724732 -0.6161 -0.7483 5417040.0 -121000.0 -0.13 5291520.0 -133000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I06 mock treatment 4395720.0 170152.38095238 0.188139248112965 0.4137 0.8407 5946240.0 409000.0 0.45 5505120.0 80700.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I07 compound treatment 2896880.0 -1328687.61904762 -1.46914364774352 -2.5792 -0.9959 3187297 PK04_093165 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)O 4017600.0 -1520000.0 -1.66 4095720.0 -1330000.0 -1.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I08 compound treatment 4372120.0 146552.38095238 0.162044483933857 0.1524 0.6702 3068413 PK04_093166 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 5676200.0 139000.0 0.15 5374920.0 -49500.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I09 compound treatment 4355680.0 130112.38095238 0.143866605836208 0.3277 0.8193 3187298 PK04_093167 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 5874800.0 337000.0 0.37 5478720.0 54300.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I10 compound treatment 3891680.0 -333887.61904762 -0.369182994973358 -0.8537 -0.896 3187366 PK04_093168 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 5286120.0 -252000.0 -0.28 4593400.0 -831000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I11 compound treatment 4117840.0 -107727.61904762 -0.119115542992557 0.5416 0.7154 3068416 PK04_093169 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 6028280.0 491000.0 0.54 5942520.0 518000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I12 compound treatment 3147400.0 -1078167.61904762 -1.19214109172022 -2.428 -0.9909 3187367 PK04_093170 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 4295040.0 -1240000.0 -1.36 3777880.0 -1650000.0 -1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I13 compound treatment 4202600.0 -22967.6190476203 -0.0253955340170858 -0.1245 -0.2444 3068419 PK04_093171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)O 5767640.0 230000.0 0.25 4983880.0 -441000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I14 compound treatment 2834960.0 -1390607.61904762 -1.53760923240328 -3.6986 -0.951 3187368 PK04_093172 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 2698640.0 -2840000.0 -3.11 3671240.0 -1750000.0 -1.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I15 compound treatment 4334520.0 108952.38095238 0.120469774902737 0.2171 0.9603 3068421 PK04_093173 COC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 5694880.0 157000.0 0.17 5507520.0 83100.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I16 compound treatment 2772760.0 -1452807.61904762 -1.60638441596008 -3.863 -0.973 3187369 PK04_093174 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 2890440.0 -2650000.0 -2.9 3246760.0 -2180000.0 -2.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I17 compound treatment 4532800.0 307232.38095238 0.339710022421101 0.0346 0.0846 3068423 PK04_093175 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)O 5481480.0 -56200.0 -0.06 5206920.0 -218000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I18 compound treatment 4177280.0 -48287.6190476203 -0.0533921199922974 0.4578 0.7077 3187370 PK04_093176 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 6078960.0 541000.0 0.59 5677160.0 253000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I19 compound treatment 3072880.0 -1152687.61904762 -1.27453862674679 -2.9797 -0.9817 3187371 PK04_093177 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 3640720.0 -1900000.0 -2.08 3621880.0 -1800000.0 -1.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I20 compound treatment 3174840.0 -1050727.61904762 -1.16180039981027 -3.2309 -0.9632 3068425 PK04_093178 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 3685240.0 -1850000.0 -2.03 3027320.0 -2400000.0 -2.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I21 mock treatment 4528200.0 302632.38095238 0.334623754826868 0.2503 0.5236 5798680.0 261000.0 0.29 5238240.0 -186000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I22 mock treatment 4320920.0 95352.3809523797 0.105432114189354 -0.2337 -0.6026 5366440.0 -171000.0 -0.19 5102840.0 -322000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I23 compound treatment 3420920.0 -804647.61904762 -0.889707197725753 -1.0119 -0.9071 3187372 PK04_093179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 5326720.0 -211000.0 -0.23 4794840.0 -630000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 I24 compound treatment 4323440.0 97872.3809523797 0.108218504262716 -1.4033 -0.7764 3068456 PK04_093180 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 4262400.0 -1280000.0 -1.4 4286280.0 -1140000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J01 compound treatment 1608800.0 -2616767.61904762 -2.89338703095642 -6.2902 -0.9887 3187373 PK04_093181 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 1691400.0 -3850000.0 -4.21 1648480.0 -3780000.0 -3.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J02 compound treatment 1974400.0 -2251167.61904762 -2.48913932824957 -5.1284 -0.9893 3187374 PK04_093182 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2305200.0 -3230000.0 -3.54 2581120.0 -2840000.0 -2.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J03 compound treatment 3146680.0 -1078887.61904762 -1.19293720316975 -4.0627 -0.9416 3068460 PK04_093183 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 2646520.0 -2890000.0 -3.17 2756280.0 -2670000.0 -2.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J04 compound treatment 4451560.0 225992.38095238 0.249882113865564 -0.1955 -0.2864 3187375 PK04_093184 COCCCNC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 5578840.0 41200.0 0.05 4793080.0 -631000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J05 mock treatment 4196720.0 -28847.6190476203 -0.0318971108549311 -0.1942 -0.8153 5461160.0 -76500.0 -0.08 5204520.0 -220000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J06 mock treatment 4540400.0 314832.38095238 0.348113421055051 0.1797 0.4881 5596640.0 59000.0 0.06 5323440.0 -101000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J07 compound treatment 1924400.0 -2301167.61904762 -2.54442484557819 -5.1365 -0.994 3187376 PK04_093185 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 2486280.0 -3050000.0 -3.34 2424560.0 -3000000.0 -3.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J08 compound treatment 1992080.0 -2233487.61904762 -2.46959036932218 -4.9025 -0.9954 3068463 PK04_093186 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 2679520.0 -2860000.0 -3.13 2542960.0 -2880000.0 -2.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J09 compound treatment 2882960.0 -1342607.61904762 -1.48453513576781 -2.5814 -0.9906 3187377 PK04_093187 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 3944000.0 -1590000.0 -1.75 4187480.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J10 compound treatment 2781960.0 -1443607.61904762 -1.59621188077162 -3.233 -0.9923 3068465 PK04_093188 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCCCC4 3561200.0 -1980000.0 -2.16 3592000.0 -1830000.0 -1.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J11 compound treatment 455920.0 -3769647.61904762 -4.16813837531274 -7.9178 -0.997 3187378 PK04_093189 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 946440.0 -4590000.0 -5.03 922520.0 -4500000.0 -4.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J12 compound treatment 4581480.0 355912.38095238 0.393536002092243 0.3227 0.7766 3068467 PK04_093190 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 5571800.0 34100.0 0.04 5552000.0 128000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J13 compound treatment 2351920.0 -1873647.61904762 -2.07171155821159 -4.6145 -0.9849 3187379 PK04_093191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 2598800.0 -2940000.0 -3.22 2731600.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J14 compound treatment 1434240.0 -2791327.61904762 -3.08639982905409 -6.2226 -0.9931 3187380 PK04_093192 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1772280.0 -3770000.0 -4.12 1869280.0 -3560000.0 -3.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J15 compound treatment 3365000.0 -860567.61904762 -0.951538520306078 -2.1177 -0.9837 3068470 PK04_093193 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 4169000.0 -1370000.0 -1.5 4211160.0 -1210000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J16 compound treatment 4461560.0 235992.38095238 0.260939217331288 0.1859 0.3992 3187381 PK04_093194 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 5318080.0 -220000.0 -0.24 5724880.0 300000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J17 compound treatment 3240160.0 -985407.61904762 -1.08957539997217 -2.3045 -0.989 3187382 PK04_093195 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 4327600.0 -1210000.0 -1.33 3853320.0 -1570000.0 -1.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J18 compound treatment 1537320.0 -2688247.61904762 -2.97242320652941 -6.1172 -0.9924 3068473 PK04_093196 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCc4ccccc4 1848760.0 -3690000.0 -4.04 1854200.0 -3570000.0 -3.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J19 compound treatment 3896360.0 -329207.61904762 -0.364008270551399 -0.9899 -0.9412 3187383 PK04_093197 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 5081320.0 -456000.0 -0.5 4576680.0 -848000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J20 compound treatment 3036600.0 -1188967.61904762 -1.31465379812043 -2.3788 -0.981 3068475 PK04_093198 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 3956600.0 -1580000.0 -1.73 4354120.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J21 mock treatment 4538720.0 313152.38095238 0.346255827672809 0.7659 0.9772 6061400.0 524000.0 0.57 5829800.0 405000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J22 mock treatment 4174560.0 -51007.6190476203 -0.0563996521349742 0.1745 0.6532 5741520.0 204000.0 0.22 5559320.0 135000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J23 compound treatment 3705800.0 -519767.61904762 -0.574712434194224 -1.1479 -0.938 3187384 PK04_093199 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 4627280.0 -910000.0 -1.0 5009320.0 -415000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 J24 compound treatment 3260320.0 -965247.61904762 -1.06728427938527 -3.9362 -0.9306 3068477 PK04_093200 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 2611000.0 -2930000.0 -3.21 2888080.0 -2540000.0 -2.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K01 compound treatment 3885080.0 -340487.61904762 -0.376480683260735 -1.2848 -0.933 3187385 PK04_093201 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 4831040.0 -707000.0 -0.77 4353280.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K02 compound treatment 2286120.0 -1939447.61904762 -2.14446729901604 -4.5084 -0.9923 3187386 PK04_093202 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 2943320.0 -2590000.0 -2.84 2611280.0 -2810000.0 -2.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K03 compound treatment 4585480.0 359912.38095238 0.397958843478532 -0.4882 -0.4286 3187447 PK04_093203 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 4579560.0 -958000.0 -1.05 5230920.0 -194000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K04 compound treatment 2707440.0 -1518127.61904762 -1.67860941579819 -4.0432 -0.9708 3068500 PK04_093204 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 2722200.0 -2820000.0 -3.08 3191280.0 -2230000.0 -2.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K05 compound treatment 2120280.0 -2105287.61904762 -2.3278383028916 -4.9759 -0.9911 3187448 PK04_093205 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 2686360.0 -2850000.0 -3.12 2267600.0 -3160000.0 -3.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K06 compound treatment 1248280.0 -2977287.61904762 -3.29201772510268 -6.4865 -0.995 3187449 PK04_093206 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1693600.0 -3840000.0 -4.21 1704560.0 -3720000.0 -3.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K07 mock treatment 4523200.0 297632.38095238 0.329095203094007 0.2321 0.6883 5604960.0 67300.0 0.07 5423720.0 -705.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K08 mock treatment 4401280.0 175712.38095238 0.194286997639907 0.626 0.9399 6008040.0 470000.0 0.52 5797960.0 374000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K09 compound treatment 4228160.0 2592.38095237967 0.00286642244130325 0.0927 0.811 3068503 PK04_093207 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 5625760.0 88100.0 0.1 5485400.0 61000.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K10 compound treatment 3138360.0 -1087207.61904762 -1.20213671325323 -1.7632 -0.9644 3187450 PK04_093208 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCCCC4 4416120.0 -1120000.0 -1.23 4803080.0 -621000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K11 compound treatment 2063280.0 -2162287.61904762 -2.39086379264623 -5.0897 -0.9903 3068506 PK04_093209 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2448760.0 -3090000.0 -3.38 2393200.0 -3030000.0 -3.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K12 compound treatment 3112160.0 -1113407.61904762 -1.23110632433343 -2.2817 -0.9954 3187451 PK04_093210 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4171920.0 -1370000.0 -1.5 4203480.0 -1220000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K13 compound treatment 4423120.0 197552.38095238 0.218435711609047 0.4311 0.7886 3187452 PK04_093211 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 5563160.0 25500.0 0.03 5923000.0 499000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K14 compound treatment 3370560.0 -855007.61904762 -0.945390770779136 -1.9255 -0.9659 3068509 PK04_093212 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 4140400.0 -1400000.0 -1.53 4568080.0 -856000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K15 mock treatment 4535840.0 310272.38095238 0.343071381874681 0.8188 0.9714 6107400.0 570000.0 0.62 5874040.0 450000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K16 mock treatment 4407960.0 182392.38095238 0.20167314275501 0.328 0.9283 5620680.0 83000.0 0.09 5698920.0 274000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K17 compound treatment 4338880.0 113312.38095238 0.125290672013793 0.4877 0.8043 3187453 PK04_093213 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)O 6063200.0 526000.0 0.58 5567760.0 143000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K18 compound treatment 4128200.0 -97367.6190476203 -0.107660383802068 0.0637 0.1913 3187454 PK04_093214 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 5459720.0 -78000.0 -0.09 5726720.0 302000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K19 compound treatment 1484240.0 -2741327.61904762 -3.03111431172547 -5.9106 -0.99 3068511 PK04_093215 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1796480.0 -3740000.0 -4.1 2326160.0 -3100000.0 -3.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K20 compound treatment 2211720.0 -2013847.61904762 -2.22673214880103 -4.0079 -0.9992 3187455 PK04_093216 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 3308040.0 -2230000.0 -2.44 3159080.0 -2270000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K21 compound treatment 4351480.0 125912.38095238 0.139222622380604 -0.5593 -0.6777 3068513 PK04_093217 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 5173080.0 -365000.0 -0.4 4718280.0 -706000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K22 compound treatment 2619600.0 -1605967.61904762 -1.7757350126411 -4.3518 -0.9751 3187456 PK04_093218 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 2644240.0 -2890000.0 -3.17 2840520.0 -2580000.0 -2.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K23 mock treatment 3902000.0 -323567.61904762 -0.357772064196731 -0.4343 -0.8926 5244000.0 -294000.0 -0.32 5351840.0 -72600.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 K24 mock treatment 4866240.0 640672.38095238 0.708398080382182 -0.1322 -0.1359 5064040.0 -474000.0 -0.52 5007280.0 -417000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L01 compound treatment 2316400.0 -1909167.61904762 -2.11098638972183 -4.6393 -0.9885 3187457 PK04_093219 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 2740800.0 -2800000.0 -3.06 2573040.0 -2850000.0 -2.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L02 compound treatment 3323280.0 -902287.61904762 -0.997668755965076 -3.5231 -0.9362 3068516 PK04_093220 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 3448120.0 -2090000.0 -2.29 2618320.0 -2810000.0 -2.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L03 compound treatment 2405960.0 -1819607.61904762 -2.01195897108282 -4.3471 -0.9888 3187458 PK04_093221 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 2864240.0 -2670000.0 -2.93 2843920.0 -2580000.0 -2.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L04 compound treatment 3619040.0 -606527.61904762 -0.670643863862841 -1.4302 -0.9881 3187459 PK04_093222 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 4637560.0 -900000.0 -0.99 4606480.0 -818000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L05 compound treatment 2235760.0 -1989807.61904762 -2.20015087206943 -3.8627 -0.9977 3068518 PK04_093223 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 3656840.0 -1880000.0 -2.06 3002560.0 -2420000.0 -2.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L06 compound treatment 2023120.0 -2202447.61904762 -2.43526912016457 -3.6303 -0.9928 3187460 PK04_093224 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 3867640.0 -1670000.0 -1.83 3407920.0 -2020000.0 -2.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L07 mock treatment 1689200.0 -2536367.61904762 -2.80448791909201 -5.5057 -0.9965 2474680.0 -3060000.0 -3.35 2059120.0 -3370000.0 -3.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L08 mock treatment 3297640.0 -927927.61904762 -1.02601916925119 -0.9311 -0.812 5463440.0 -74200.0 -0.08 4920840.0 -504000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L09 compound treatment 2434560.0 -1791007.61904762 -1.98033565517085 -4.2144 -0.9856 3068520 PK04_093225 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 3409280.0 -2130000.0 -2.33 2446760.0 -2980000.0 -2.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L10 compound treatment 4284520.0 58952.3809523797 0.0651842575741204 0.1374 0.3915 3187461 PK04_093226 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N 5408320.0 -129000.0 -0.14 5737840.0 313000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L11 compound treatment 2134520.0 -2091047.61904762 -2.31209298755641 -3.9775 -0.9984 3187462 PK04_093227 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 3594640.0 -1940000.0 -2.13 2983880.0 -2440000.0 -2.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L12 compound treatment 4080840.0 -144727.61904762 -0.160026825815734 -0.1361 -0.5785 3187463 PK04_093228 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCC(O)CO 5608960.0 71300.0 0.08 5271200.0 -153000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L13 compound treatment 1690280.0 -2535287.61904762 -2.80329375191771 -5.5929 -0.9943 3068543 PK04_093229 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 2203200.0 -3330000.0 -3.65 2203720.0 -3220000.0 -3.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L14 compound treatment 1493360.0 -2732207.61904762 -3.02103023336473 -5.752 -0.9976 3187464 PK04_093230 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 2265280.0 -3270000.0 -3.58 2078400.0 -3350000.0 -3.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L15 mock treatment 4356480.0 130912.38095238 0.144751174113466 0.9917 0.8813 6314920.0 777000.0 0.85 6143640.0 719000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L16 mock treatment 4687120.0 461552.38095238 0.510343243104145 0.6553 0.9471 5724600.0 187000.0 0.2 5842960.0 419000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L17 compound treatment 3383120.0 -842447.61904762 -0.931503048826187 -1.1538 -0.9621 3068545 PK04_093231 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 5027920.0 -510000.0 -0.56 4917600.0 -507000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L18 compound treatment 1749400.0 -2476167.61904762 -2.73792415622835 -5.191 -0.991 3187465 PK04_093232 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 2278280.0 -3260000.0 -3.57 2750240.0 -2670000.0 -2.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L19 compound treatment 2811640.0 -1413927.61904762 -1.56339439768535 -2.6123 -0.8935 3187466 PK04_093233 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 3339280.0 -2200000.0 -2.41 4872680.0 -552000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L20 compound treatment 3661120.0 -564447.61904762 -0.624115572479077 -0.5756 -0.8219 3068547 PK04_093234 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 5481880.0 -55800.0 -0.06 5113800.0 -311000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L21 compound treatment 3609360.0 -616207.61904762 -0.681347140017661 -0.9308 -0.8713 3187467 PK04_093235 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CC=C)C3=O 4793840.0 -744000.0 -0.81 5308600.0 -116000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L22 compound treatment 1908440.0 -2317127.61904762 -2.56207198270949 -4.953 -0.9961 3068549 PK04_093236 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 2946560.0 -2590000.0 -2.84 2256520.0 -3170000.0 -3.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L23 mock treatment 4299320.0 73752.3809523797 0.081548770703391 -0.2408 -0.6289 5390800.0 -147000.0 -0.16 5087920.0 -337000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 L24 mock treatment 4141600.0 -83967.6190476203 -0.0928438651579985 -0.9901 -0.7685 4422880.0 -1110000.0 -1.22 5024600.0 -400000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M01 compound treatment 2122440.0 -2103127.61904762 -2.32544996854301 -5.0983 -0.989 3187528 PK04_093237 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2504640.0 -3030000.0 -3.32 2252280.0 -3170000.0 -3.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M02 compound treatment 2580840.0 -1644727.61904762 -1.81859234567424 -3.8903 -0.9903 3187529 PK04_093238 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 3188960.0 -2350000.0 -2.57 3085360.0 -2340000.0 -2.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M03 compound treatment 4710440.0 484872.38095238 0.536128408386212 0.3654 0.6635 3068551 PK04_093239 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 5650120.0 112000.0 0.12 5398160.0 -26300.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M04 compound treatment 3821160.0 -404407.61904762 -0.447157688613639 -1.3153 -0.96 3187530 PK04_093240 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 4680640.0 -857000.0 -0.94 4535120.0 -889000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M05 compound treatment 4389960.0 164392.38095238 0.181770356516708 0.5341 0.9602 3068553 PK04_093241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 5870400.0 333000.0 0.36 5801960.0 378000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M06 compound treatment 3324800.0 -900767.61904762 -0.995988076238286 -0.9868 -0.8779 3187531 PK04_093242 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 5127880.0 -410000.0 -0.45 5161000.0 -263000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M07 compound treatment 4513000.0 287432.38095238 0.317816957558969 0.1878 0.5902 3187532 PK04_093243 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 5532880.0 -4810.0 -0.01 5437040.0 12600.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M08 compound treatment 2035400.0 -2190167.61904762 -2.42169099710866 -4.9861 -0.9924 3068555 PK04_093244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 2531120.0 -3010000.0 -3.29 2512960.0 -2910000.0 -2.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M09 mock treatment 4202520.0 -23047.6190476203 -0.0254839908448116 -0.0896 -0.243 5248600.0 -289000.0 -0.32 5610720.0 186000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M10 mock treatment 4790240.0 564672.38095238 0.624364094042684 0.9994 0.9983 6048200.0 511000.0 0.56 5970120.0 546000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M11 compound treatment 4593400.0 367832.38095238 0.406716069423385 0.686 0.9975 3187533 PK04_093245 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 5925000.0 387000.0 0.42 5780520.0 356000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M12 compound treatment 2004000.0 -2221567.61904762 -2.45641030199103 -4.1713 -0.9938 3187534 PK04_093246 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 3062440.0 -2480000.0 -2.71 3373960.0 -2050000.0 -2.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M13 mock treatment 4796720.0 571152.38095238 0.631529097088473 0.8073 0.9301 5728880.0 191000.0 0.21 5979760.0 555000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M14 mock treatment 4779360.0 553792.38095238 0.612333965471977 1.338 0.9782 6183840.0 646000.0 0.71 6418400.0 994000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M15 compound treatment 4253440.0 27872.3809523797 0.030818780002652 0.2246 0.5349 3068558 PK04_093247 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 5485880.0 -51800.0 -0.06 5837960.0 414000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M16 compound treatment 5098480.0 872912.38095238 0.965188251270143 1.0698 0.9212 3187535 PK04_093248 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 5845320.0 308000.0 0.34 5973240.0 549000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M17 compound treatment 4453720.0 228152.38095238 0.25227044821416 -0.1142 -0.0974 3068560 PK04_093249 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 6041880.0 504000.0 0.55 4425840.0 -999000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M18 compound treatment 3503480.0 -722087.61904762 -0.79841975151274 -1.8086 -0.9799 3187536 PK04_093250 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 4335320.0 -1200000.0 -1.32 4410680.0 -1010000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M19 compound treatment 4538440.0 312872.38095238 0.345946228775769 0.3389 0.8216 3187537 PK04_093251 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 5553200.0 15500.0 0.02 5647760.0 223000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M20 compound treatment 4251600.0 26032.3809523797 0.0287842729649589 0.0402 0.6686 3068562 PK04_093252 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCOCC3 5584840.0 47200.0 0.05 5413640.0 -10800.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M21 compound treatment 4327520.0 101952.38095238 0.112729802476731 0.1815 0.7078 3068586 PK04_093253 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 5512960.0 -24700.0 -0.03 5652360.0 228000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M22 compound treatment 3829520.0 -396047.61904762 -0.437913950116295 -0.5418 -0.8865 3187538 PK04_093254 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 5155720.0 -382000.0 -0.42 5342480.0 -81900.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M23 compound treatment 1488280.0 -2737287.61904762 -3.02664724192532 -6.0391 -0.9957 3068589 PK04_093255 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2135600.0 -3400000.0 -3.73 1729880.0 -3690000.0 -3.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 M24 compound treatment 3744600.0 -480967.61904762 -0.531810872747218 -2.4183 -0.9042 3187539 PK04_093256 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 3591080.0 -1950000.0 -2.13 3904840.0 -1520000.0 -1.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N01 compound treatment 2068120.0 -2157447.61904762 -2.38551215456881 -5.1781 -0.987 3187540 PK04_093257 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 2268960.0 -3270000.0 -3.58 2431640.0 -2990000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N02 compound treatment 2689800.0 -1535767.61904762 -1.69811414631172 -3.9174 -0.9836 3187541 PK04_093258 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 3087480.0 -2450000.0 -2.68 3029160.0 -2400000.0 -2.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N03 compound treatment 2476400.0 -1749167.61904762 -1.93407273427026 -5.3301 -0.966 3068594 PK04_093259 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CC=C)C3=O)[C@@H](O2)c5ccccc5 2031520.0 -3510000.0 -3.84 1978560.0 -3450000.0 -3.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N04 compound treatment 5305360.0 1079792.38095238 1.19393760776903 1.0747 0.8272 3187542 PK04_093260 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 5713960.0 176000.0 0.19 5897160.0 473000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N05 compound treatment 2815040.0 -1410527.61904762 -1.559634982507 -3.0969 -0.9306 3068597 PK04_093261 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CC=C)C3=O 4565960.0 -972000.0 -1.06 2693960.0 -2730000.0 -2.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N06 compound treatment 5472120.0 1246552.38095238 1.37832586516343 1.4249 0.9017 3187543 PK04_093262 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 5994440.0 457000.0 0.5 6011840.0 587000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N07 compound treatment 2201720.0 -2023847.61904762 -2.23778925226675 -3.7774 -0.986 3187544 PK04_093263 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CC=C)C3=O)[C@H](O2)c5ccccc5 3162320.0 -2380000.0 -2.6 3726880.0 -1700000.0 -1.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N08 compound treatment 1299840.0 -2925727.61904762 -3.23500729963341 -6.7152 -0.9912 3068600 PK04_093264 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1423480.0 -4110000.0 -4.51 1547800.0 -3880000.0 -3.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N09 mock treatment 4270120.0 44552.3809523797 0.0492620285834787 0.6215 0.648 5603560.0 65900.0 0.07 6376080.0 952000.0 0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N10 mock treatment 5160920.0 935352.38095238 1.03422880531012 0.6925 0.6574 5718200.0 181000.0 0.2 5392080.0 -32300.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N11 compound treatment 2008840.0 -2216727.61904762 -2.45105866391362 -4.565 -0.9822 3187545 PK04_093265 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 2502280.0 -3040000.0 -3.32 3300440.0 -2120000.0 -2.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N12 compound treatment 4679920.0 454352.38095238 0.502382128608824 0.1378 0.1695 3187546 PK04_093266 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 5811960.0 274000.0 0.3 4862400.0 -562000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N13 mock treatment 4672240.0 446672.38095238 0.493890273147148 1.2236 0.964 6418320.0 881000.0 0.96 6083080.0 659000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N14 mock treatment 4510800.0 285232.38095238 0.31538439479651 0.4585 0.9901 5768920.0 231000.0 0.25 5649240.0 225000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N15 compound treatment 2582960.0 -1642607.61904762 -1.81624823973951 -3.9349 -0.9874 3068603 PK04_093267 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 3446520.0 -2090000.0 -2.29 2724920.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N16 compound treatment 4434440.0 208872.38095238 0.230952352732246 0.4399 0.8893 3187547 PK04_093268 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 5635200.0 97500.0 0.11 5847160.0 423000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N17 compound treatment 2263440.0 -1962127.61904762 -2.16954480967631 -4.6134 -0.9915 3068605 PK04_093269 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 2903280.0 -2630000.0 -2.88 2498760.0 -2930000.0 -2.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N18 compound treatment 2208560.0 -2017007.61904762 -2.2302261934962 -4.495 -0.995 3187548 PK04_093270 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 2971000.0 -2570000.0 -2.81 2689760.0 -2730000.0 -2.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N19 compound treatment 3200440.0 -1025127.61904762 -1.13349421493802 -2.1867 -0.9896 3068607 PK04_093271 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CC=C)C3=O 4503840.0 -1030000.0 -1.13 3908120.0 -1520000.0 -1.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N20 compound treatment 3764760.0 -460807.61904762 -0.509519752160319 -1.4744 -0.9601 3186297 PK04_093272 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4541480.0 -996000.0 -1.09 4474640.0 -950000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N21 compound treatment 2646680.0 -1578887.61904762 -1.74579237645592 -3.1712 -0.966 3186298 PK04_093273 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CC=C)C3=O)[C@@H](O2)c5ccccc5 3283280.0 -2250000.0 -2.47 4150920.0 -1270000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N22 compound treatment 5209720.0 984152.38095238 1.08818747022285 0.6325 0.5781 3068610 PK04_093274 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 5614320.0 76600.0 0.08 5348160.0 -76300.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N23 compound treatment 1898320.0 -2327247.61904762 -2.5732617714168 -5.2703 -0.9935 3068635 PK04_093275 CC(=O)N1Cc2ccccc2C[C@]3(N=C(O[C@@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 2422600.0 -3120000.0 -3.41 2291920.0 -3130000.0 -3.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 N24 compound treatment 2920400.0 -1305167.61904762 -1.44313734039214 -3.6892 -0.9748 3186299 PK04_093276 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 3233160.0 -2300000.0 -2.52 3010000.0 -2410000.0 -2.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O01 compound treatment 1789160.0 -2436407.61904762 -2.69396111284864 -5.2629 -0.9965 3068638 PK04_093277 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 2682600.0 -2860000.0 -3.13 2141160.0 -3280000.0 -3.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O02 compound treatment 2371360.0 -1854207.61904762 -2.05021654907422 -4.4638 -0.9895 3186300 PK04_093278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 2885560.0 -2650000.0 -2.9 2657400.0 -2770000.0 -2.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O03 compound treatment 1610840.0 -2614727.61904762 -2.89113138184941 -7.0087 -0.9802 3068640 PK04_093279 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1262400.0 -4280000.0 -4.68 874320.0 -4550000.0 -4.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O04 compound treatment 4346800.0 121232.38095238 0.134047897958646 -0.5327 -0.6527 3186301 PK04_093280 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 5248800.0 -289000.0 -0.32 4686760.0 -738000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O05 compound treatment 4718640.0 493072.38095238 0.545195233228105 -0.416 -0.3944 3068642 PK04_093281 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)O 5036480.0 -501000.0 -0.55 4710200.0 -714000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O06 compound treatment 4495320.0 269752.38095238 0.29826799863157 -0.1977 -0.2911 3186302 PK04_093282 COCCCNC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 5509160.0 -28500.0 -0.03 4817080.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O07 compound treatment 4332480.0 106912.38095238 0.11821412579573 0.1236 0.6091 3186303 PK04_093283 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 5484360.0 -53300.0 -0.06 5578200.0 154000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O08 compound treatment 2502640.0 -1722927.61904762 -1.9050588947762 -3.4966 -0.982 3068645 PK04_093284 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 4067800.0 -1470000.0 -1.61 2891960.0 -2530000.0 -2.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O09 compound treatment 744240.0 -3481327.61904762 -3.84933996818901 -7.9204 -0.9915 3186304 PK04_093285 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 679000.0 -4860000.0 -5.32 892240.0 -4530000.0 -4.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O10 compound treatment 2663520.0 -1562047.61904762 -1.72717221421964 -4.3085 -0.9771 3186305 PK04_093286 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 2996960.0 -2540000.0 -2.78 2482000.0 -2940000.0 -2.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O11 mock treatment 5034680.0 809112.38095238 0.894643931158827 0.77 0.8109 5692200.0 155000.0 0.17 5693360.0 269000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O12 mock treatment 4564160.0 338592.38095238 0.37438509888961 0.3744 0.6776 5432240.0 -105000.0 -0.12 5812560.0 388000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O13 compound treatment 4063400.0 -162167.61904762 -0.179310414259956 -1.3026 -0.88 3068648 PK04_093287 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 4560480.0 -977000.0 -1.07 4421240.0 -1000000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O14 compound treatment 4001800.0 -223767.61904762 -0.247422171608812 -0.7124 -0.9359 3186306 PK04_093288 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 5202080.0 -336000.0 -0.37 4807640.0 -617000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O15 compound treatment 4171640.0 -53927.6190476203 -0.0596283263469654 -0.3226 -0.626 3068650 PK04_093289 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 5549160.0 11500.0 0.01 4914480.0 -510000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O16 compound treatment 3196160.0 -1029407.61904762 -1.13822665522135 -2.1685 -0.9931 3186307 PK04_093290 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4203360.0 -1330000.0 -1.46 4272120.0 -1150000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O17 compound treatment 1956240.0 -2269327.61904762 -2.50921902814333 -5.1278 -0.9922 3186308 PK04_093291 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2415080.0 -3120000.0 -3.42 2482240.0 -2940000.0 -2.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O18 compound treatment 3670360.0 -555207.61904762 -0.613898808876748 -1.2625 -0.9474 3068652 PK04_093292 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 5079560.0 -458000.0 -0.5 4357200.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O19 compound treatment 1452960.0 -2772607.61904762 -3.06570093136626 -5.2302 -0.9914 3186309 PK04_093293 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2358200.0 -3180000.0 -3.48 2922040.0 -2500000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O20 compound treatment 2688960.0 -1536607.61904762 -1.69904294300284 -2.9169 -0.9939 3068654 PK04_093294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCOCC4 3797760.0 -1740000.0 -1.91 3981920.0 -1440000.0 -1.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O21 compound treatment 819680.0 -3405887.61904762 -3.76592517964359 -6.9854 -0.995 3186310 PK04_093295 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2134160.0 -3400000.0 -3.73 835000.0 -4590000.0 -4.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O22 compound treatment 4406240.0 180672.38095238 0.199771320958906 -0.3407 -0.5607 3186311 PK04_093296 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 5262040.0 -276000.0 -0.3 4938160.0 -486000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O23 compound treatment 3211840.0 -1013727.61904762 -1.1208891169871 -2.3635 -0.9644 3068656 PK04_093297 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4551840.0 -986000.0 -1.08 3537920.0 -1890000.0 -1.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 O24 compound treatment 2828520.0 -1397047.61904762 -1.54473000703521 -3.0753 -0.9958 3186312 PK04_093298 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCc4ccccc4 3823480.0 -1710000.0 -1.88 3526560.0 -1900000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P01 compound treatment 1715080.0 -2510487.61904762 -2.77587213532271 -5.8035 -0.9921 3186313 PK04_093299 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 2082560.0 -3460000.0 -3.78 1944520.0 -3480000.0 -3.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P02 compound treatment 1520240.0 -2705327.61904762 -2.99130873924887 -6.584 -0.9877 3186314 PK04_093300 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1494160.0 -4040000.0 -4.43 1454200.0 -3970000.0 -3.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P03 compound treatment 1911040.0 -2314527.61904762 -2.5591971358084 -5.5726 -0.9886 3067960 PK04_093301 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 2131600.0 -3410000.0 -3.73 2073720.0 -3350000.0 -3.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P04 compound treatment 1980520.0 -2245047.61904762 -2.48237238092855 -5.7099 -0.9843 3186315 PK04_093302 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2307240.0 -3230000.0 -3.54 1568520.0 -3860000.0 -3.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P05 compound treatment 3018080.0 -1207487.61904762 -1.33513155373895 -3.2461 -0.9428 3186316 PK04_093303 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CC=C)C3=O 4186440.0 -1350000.0 -1.48 2626880.0 -2800000.0 -2.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P06 compound treatment 2100600.0 -2124967.61904762 -2.34959868251215 -4.7689 -0.9886 3067963 PK04_093304 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 3182120.0 -2360000.0 -2.58 2105520.0 -3320000.0 -3.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P07 compound treatment 3459520.0 -766047.61904762 -0.847026778348061 -2.5201 -0.9434 3186317 PK04_093305 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CC=C)C3=O 3621360.0 -1920000.0 -2.1 4010120.0 -1410000.0 -1.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P08 compound treatment 2792960.0 -1432607.61904762 -1.58404906695932 -3.3025 -0.9863 3186362 PK04_093306 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3899160.0 -1640000.0 -1.79 3091120.0 -2330000.0 -2.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P09 compound treatment 2099040.0 -2126527.61904762 -2.3513235906528 -5.3796 -0.9778 3067965 PK04_093307 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1913000.0 -3620000.0 -3.97 2438200.0 -2990000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P10 compound treatment 3899320.0 -326247.61904762 -0.360735367925545 -0.9254 -0.9575 3186363 PK04_093308 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 5086960.0 -451000.0 -0.49 4678520.0 -746000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P11 mock treatment 4590840.0 365272.38095238 0.40388545093616 0.0379 0.0727 5236800.0 -301000.0 -0.33 5415680.0 -8750.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P12 mock treatment 3974960.0 -250607.61904762 -0.277099437310813 -0.7461 -0.8738 4835200.0 -702000.0 -0.77 5179400.0 -245000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P13 compound treatment 988720.0 -3236847.61904762 -3.579015902659 -6.9081 -0.9963 3186364 PK04_093309 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1504240.0 -4030000.0 -4.42 1469440.0 -3950000.0 -3.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P14 compound treatment 3209520.0 -1016047.61904762 -1.12345436499115 -1.7247 -0.9957 3067968 PK04_093310 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 4664840.0 -873000.0 -0.96 4519680.0 -905000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P15 compound treatment 2340320.0 -1885247.61904762 -2.08453779823182 -3.3229 -0.9931 3186365 PK04_093311 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 4078960.0 -1460000.0 -1.6 3358360.0 -2070000.0 -2.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P16 compound treatment 4571680.0 346112.38095238 0.382700040695834 -0.1936 -0.2962 3186366 PK04_093312 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 5112480.0 -425000.0 -0.47 5173000.0 -251000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P17 compound treatment 2029160.0 -2196407.61904762 -2.42859062967127 -4.744 -0.9957 3067970 PK04_093313 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 3040560.0 -2500000.0 -2.73 2381760.0 -3040000.0 -3.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P18 compound treatment 3599080.0 -626487.61904762 -0.692713842380425 -1.5991 -0.9751 3186367 PK04_093314 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 4737360.0 -800000.0 -0.88 4228160.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P19 compound treatment 2340400.0 -1885167.61904762 -2.0844493414041 -4.4182 -0.991 3067972 PK04_093315 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CC=C)C3=O)[C@H](O2)c5ccccc5 3107440.0 -2430000.0 -2.66 2528120.0 -2900000.0 -2.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P20 compound treatment 2526560.0 -1699007.61904762 -1.87861030328619 -4.0463 -0.9898 3186368 PK04_093316 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 3298320.0 -2240000.0 -2.45 2756480.0 -2670000.0 -2.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P21 compound treatment 1891160.0 -2334407.61904762 -2.58117865749826 -5.1345 -0.9956 3067974 PK04_093317 CC(=O)N1Cc2ccccc2C[C@@]3(N=C(O[C@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 2577880.0 -2960000.0 -3.24 2364720.0 -3060000.0 -3.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P22 compound treatment 3866480.0 -359087.61904762 -0.397046895706981 -1.233 -0.9511 3186369 PK04_093318 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 4674440.0 -863000.0 -0.95 4634080.0 -790000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P23 compound treatment 3771560.0 -454007.61904762 -0.502000921803627 -2.492 -0.9083 3067976 PK04_093319 CC(=O)N1Cc2ccccc2C[C@@]3(COC(=N3)c4ccc(OCCCO)cc4)C1=O 3770440.0 -1770000.0 -1.94 3552240.0 -1870000.0 -1.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2093 P24 compound treatment 2084680.0 -2140887.61904762 -2.36720159122958 -5.3592 -0.9843 3186370 PK04_093320 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 2145240.0 -3390000.0 -3.72 2235680.0 -3190000.0 -3.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A01 compound treatment 1881040.0 -3510970.625 -3.88211654657406 -6.4466 -0.9995 3186371 PK04_094001 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1688160.0 -3290000.0 -3.6 1711280.0 -3670000.0 -3.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A02 compound treatment 1839200.0 -3552810.625 -3.92837946747464 -6.487 -0.9994 3067979 PK04_094002 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1642760.0 -3330000.0 -3.65 1737120.0 -3640000.0 -3.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A03 compound treatment 2493720.0 -2898290.625 -3.20466993143612 -4.3436 -0.9801 3068002 PK04_094003 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 2869560.0 -2110000.0 -2.31 3376520.0 -2000000.0 -2.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A04 compound treatment 4398840.0 -993170.625 -1.09815903597422 -2.0121 -0.997 3186372 PK04_094004 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 3800640.0 -1180000.0 -1.29 4285520.0 -1090000.0 -1.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A05 compound treatment 4435320.0 -956690.625 -1.05782272253126 -2.449 -0.977 3068007 PK04_094005 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 3324440.0 -1650000.0 -1.81 4010840.0 -1370000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A06 compound treatment 2777080.0 -2614930.625 -2.89135584763138 -4.8756 -0.9984 3186373 PK04_094006 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2612720.0 -2360000.0 -2.59 2426520.0 -2950000.0 -2.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A07 compound treatment 3936320.0 -1455690.625 -1.60957218547086 -3.311 -0.9933 3186374 PK04_094007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 3026040.0 -1950000.0 -2.14 3398600.0 -1980000.0 -1.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A08 compound treatment 3021400.0 -2370610.625 -2.62120869575682 -4.4441 -0.9999 3068010 PK04_094008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2638480.0 -2340000.0 -2.56 2873880.0 -2510000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A09 compound treatment 4179240.0 -1212770.625 -1.3409730280815 -2.263 -0.9965 3186375 PK04_094009 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 3681600.0 -1300000.0 -1.42 4224240.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A10 compound treatment 2902920.0 -2489090.625 -2.75221325761871 -4.7634 -0.9995 3068013 PK04_094010 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 2372360.0 -2610000.0 -2.85 2743800.0 -2640000.0 -2.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A11 compound treatment 1591440.0 -3800570.625 -4.20233026294141 -6.9298 -0.9991 3186376 PK04_094011 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1321240.0 -3660000.0 -4.0 1596720.0 -3780000.0 -3.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A12 compound treatment 1864080.0 -3527930.625 -3.90086939405192 -6.3081 -0.9987 3186377 PK04_094012 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1758520.0 -3220000.0 -3.53 1892240.0 -3490000.0 -3.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A13 mock treatment 4759880.0 -632130.625 -0.69895337244774 -1.6866 -0.9805 3940800.0 -1040000.0 -1.14 4296520.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A14 mock treatment 4933480.0 -458530.625 -0.507002056282782 -1.1988 -0.9826 4264840.0 -713000.0 -0.78 4593520.0 -786000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A15 compound treatment 2681880.0 -2710130.625 -2.99661947262506 -5.2137 -0.9999 3068016 PK04_094013 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2179520.0 -2800000.0 -3.06 2420640.0 -2960000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A16 compound treatment 2456600.0 -2935410.625 -3.24571389950088 -4.5833 -0.9741 3186378 PK04_094014 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 2337080.0 -2640000.0 -2.89 3584880.0 -1790000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A17 compound treatment 4695280.0 -696730.625 -0.770382260836313 -1.7036 -0.9683 3068018 PK04_094015 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 3754120.0 -1220000.0 -1.34 4542080.0 -837000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A18 compound treatment 1408240.0 -3983770.625 -4.40489639843346 -7.2383 -0.999 3186379 PK04_094016 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1156960.0 -3820000.0 -4.18 1445400.0 -3930000.0 -3.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A19 compound treatment 2076320.0 -3315690.625 -3.66619343009541 -6.2149 -0.9998 3186380 PK04_094017 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1675720.0 -3300000.0 -3.62 1909520.0 -3470000.0 -3.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A20 compound treatment 3140360.0 -2251650.625 -2.48967339292858 -4.2743 -1.0 3068020 PK04_094018 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2742720.0 -2230000.0 -2.45 2922080.0 -2460000.0 -2.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A21 compound treatment 4341640.0 -1050370.625 -1.16140566779816 -2.5395 -0.9861 3186381 PK04_094019 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCOCC4 3364120.0 -1610000.0 -1.77 3914600.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A22 compound treatment 4273680.0 -1118330.625 -1.23654974295121 -1.9566 -0.9621 3186437 PK04_094020 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 3647160.0 -1330000.0 -1.46 4686640.0 -693000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A23 compound treatment 3941440.0 -1450570.625 -1.60391094849641 -3.097 -0.9967 3068021 PK04_094021 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 3188320.0 -1790000.0 -1.96 3585240.0 -1790000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 A24 compound treatment 3559240.0 -1832770.625 -2.02651344295636 -2.3994 -0.9445 3186438 PK04_094022 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3823280.0 -1150000.0 -1.26 4517280.0 -862000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B01 compound treatment 2795640.0 -2596370.625 -2.87083386359899 -4.9037 -0.9995 3186439 PK04_094023 CCCN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 2310480.0 -2670000.0 -2.92 2687320.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B02 compound treatment 2447640.0 -2944370.625 -3.25562106420617 -5.4617 -0.9997 3089331 PK04_094024 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 2157400.0 -2820000.0 -3.09 2274720.0 -3100000.0 -3.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B03 compound treatment 2268560.0 -3123450.625 -3.45363167307034 -4.9714 -0.9739 3068022 PK04_094025 CCCN1C(=O)[C@]2(Cc3ccccc13)N=C(O[C@@H]2c4ccccc4)c5ccc(OCCCO)cc5 2033880.0 -2940000.0 -3.22 3453040.0 -1930000.0 -1.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B04 compound treatment 1378000.0 -4014010.625 -4.43833307931381 -6.1906 -0.9844 3089332 PK04_094026 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 2314000.0 -2660000.0 -2.92 2024320.0 -3360000.0 -3.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B05 compound treatment 3430640.0 -1961370.625 -2.16870779352556 -3.5605 -0.9982 3186440 PK04_094027 CCCN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 3258440.0 -1720000.0 -1.88 3271440.0 -2110000.0 -2.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B06 compound treatment 2349320.0 -3042690.625 -3.36433450548116 -5.7566 -0.999 3000708 PK04_094028 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 2125480.0 -2850000.0 -3.12 1908960.0 -3470000.0 -3.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B07 compound treatment 2772600.0 -2619410.625 -2.89630942998402 -4.8293 -0.9989 3068023 PK04_094029 CN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 2359440.0 -2620000.0 -2.87 2787680.0 -2590000.0 -2.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B08 compound treatment 2599440.0 -2792570.625 -3.08777423359649 -4.7747 -0.9906 3089333 PK04_094030 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 2947600.0 -2030000.0 -2.22 2431000.0 -2950000.0 -2.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B09 compound treatment 2662560.0 -2729450.625 -3.01798179652084 -3.3598 -0.9147 3186441 PK04_094031 CN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 3260560.0 -1720000.0 -1.88 4461840.0 -918000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B10 compound treatment 2192720.0 -3199290.625 -3.53748874575439 -5.73 -0.9988 3089654 PK04_094032 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 2024600.0 -2950000.0 -3.23 2237520.0 -3140000.0 -3.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B11 compound treatment 2017760.0 -3374250.625 -3.73094382799069 -5.9082 -0.9977 3186442 PK04_094033 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1949600.0 -3030000.0 -3.32 2204520.0 -3180000.0 -3.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B12 compound treatment 788040.0 -4603970.625 -5.09065795537763 -8.0734 -0.9975 3089334 PK04_094034 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1054600.0 -3920000.0 -4.3 799240.0 -4580000.0 -4.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B13 mock treatment 5078800.0 -313210.625 -0.346320228718889 -0.7618 -0.9885 4519920.0 -458000.0 -0.5 4909320.0 -470000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B14 mock treatment 5461640.0 69629.375 0.0769899203628655 -0.0099 -0.0876 4966240.0 -11300.0 -0.01 5298120.0 -81400.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B15 compound treatment 4009680.0 -1382330.625 -1.52845727444631 -3.181 -0.9907 3068024 PK04_094035 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 3301880.0 -1680000.0 -1.84 3241040.0 -2140000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B16 compound treatment 2379360.0 -3012650.625 -3.33111896667013 -5.6271 -0.9998 3000709 PK04_094036 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 2004720.0 -2970000.0 -3.26 2231200.0 -3150000.0 -3.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B17 compound treatment 3701760.0 -1690250.625 -1.86892760436287 -3.3199 -0.9818 3186443 PK04_094037 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 2792960.0 -2180000.0 -2.39 3896040.0 -1480000.0 -1.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B18 compound treatment 1428920.0 -3963090.625 -4.38203030846634 -6.7805 -0.9962 3089363 PK04_094038 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1525760.0 -3450000.0 -3.78 1810320.0 -3570000.0 -3.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B19 compound treatment 2487400.0 -2904610.625 -3.21165802082645 -5.6201 -0.9999 3068025 PK04_094039 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1951000.0 -3030000.0 -3.31 2182840.0 -3200000.0 -3.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B20 compound treatment 2159400.0 -3232610.625 -3.57433101450218 -5.8944 -0.9987 3089652 PK04_094040 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1811680.0 -3170000.0 -3.47 2222760.0 -3160000.0 -3.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B21 compound treatment 3965000.0 -1427010.625 -1.57786041273116 -3.6028 -0.9585 3186444 PK04_094041 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 3415200.0 -1560000.0 -1.71 2438760.0 -2940000.0 -2.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B22 compound treatment 1935720.0 -3456290.625 -3.82165630482348 -6.1495 -0.9985 3089653 PK04_094042 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1849200.0 -3130000.0 -3.43 1987960.0 -3390000.0 -3.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B23 compound treatment 2961560.0 -2430450.625 -2.68737440289571 -5.136 -0.9943 3186445 PK04_094043 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 1864320.0 -3110000.0 -3.41 2590520.0 -2790000.0 -2.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 B24 compound treatment 3229200.0 -2162810.625 -2.39144208573909 -4.3104 -0.9992 3089657 PK04_094044 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 2745360.0 -2230000.0 -2.44 2759160.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C01 compound treatment 3906800.0 -1485210.625 -1.64221275490167 -2.9596 -0.9991 3068026 PK04_094045 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3324640.0 -1650000.0 -1.81 3711680.0 -1670000.0 -1.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C02 compound treatment 2876480.0 -2515530.625 -2.78144823918209 -5.2104 -0.9985 3068051 PK04_094046 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2080840.0 -2900000.0 -3.17 2319600.0 -3060000.0 -3.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C03 compound treatment 3840840.0 -1551170.625 -1.71514540936158 -2.3918 -0.961 3068052 PK04_094047 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 3512040.0 -1470000.0 -1.6 4559840.0 -820000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C04 compound treatment 5144280.0 -247730.625 -0.273918315225333 -0.7555 -0.9412 3068053 PK04_094048 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCOCC3 4385920.0 -592000.0 -0.65 4994200.0 -385000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C05 compound treatment 3969120.0 -1422890.625 -1.57330488610328 -2.9087 -0.9715 3068054 PK04_094049 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 3846160.0 -1130000.0 -1.24 3161800.0 -2220000.0 -2.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C06 compound treatment 4803360.0 -588650.625 -0.650877086578775 -1.1523 -0.9774 3186446 PK04_094050 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 4524040.0 -454000.0 -0.5 4534280.0 -845000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C07 compound treatment 5536560.0 144549.375 0.159829739528065 0.0457 0.1371 3068055 PK04_094051 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 4755240.0 -222000.0 -0.24 5541840.0 162000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C08 compound treatment 5182720.0 -209290.625 -0.231414809503092 -0.4007 -0.5182 3186447 PK04_094052 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4339360.0 -638000.0 -0.7 5615000.0 235000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C09 compound treatment 4342960.0 -1049050.625 -1.15994613014068 -1.981 -0.9998 3068056 PK04_094053 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 3918200.0 -1060000.0 -1.16 4272480.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C10 compound treatment 2231760.0 -3160250.625 -3.49432181382421 -4.9299 -0.9871 3186448 PK04_094054 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 2604400.0 -2370000.0 -2.6 2942680.0 -2440000.0 -2.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C11 mock treatment 5389280.0 -2730.625 -0.0030192803151091 -0.5247 -0.816 4600920.0 -377000.0 -0.41 4888040.0 -492000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C12 mock treatment 5195800.0 -196210.625 -0.216952118169926 -0.4695 -0.823 4500520.0 -477000.0 -0.52 5305960.0 -73600.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C13 compound treatment 5256640.0 -135370.625 -0.149680700684464 -0.3506 -0.9224 3186449 PK04_094055 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 4683520.0 -294000.0 -0.32 5244400.0 -135000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C14 compound treatment 4119920.0 -1272090.625 -1.40656376584018 -2.5252 -0.955 3068057 PK04_094056 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 3117960.0 -1860000.0 -2.04 4452080.0 -927000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C15 mock treatment 5461480.0 69469.375 0.0768130067074139 -0.4556 -0.6066 4305680.0 -672000.0 -0.74 5249800.0 -130000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C16 mock treatment 5435040.0 43029.375 0.0475780251440412 0.3233 0.5036 4870720.0 -107000.0 -0.12 6006640.0 627000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C17 compound treatment 5991600.0 599589.375 0.662972175632343 0.5507 0.7627 3186450 PK04_094057 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 4982080.0 4510.0 0.0 5664520.0 285000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C18 compound treatment 4824120.0 -567890.625 -0.627922539783933 -1.6509 -0.9716 3186451 PK04_094058 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 3994320.0 -983000.0 -1.08 4229000.0 -1150000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C19 compound treatment 5635800.0 243789.375 0.269560434321904 0.1484 0.5385 3068058 PK04_094059 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 4935440.0 -42100.0 -0.05 5413000.0 33500.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C20 compound treatment 1965560.0 -3426450.625 -3.78866190808176 -6.1933 -0.999 3186452 PK04_094060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1861360.0 -3120000.0 -3.41 1866280.0 -3510000.0 -3.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C21 compound treatment 5206920.0 -185090.625 -0.204656619116041 -0.7537 -0.9364 3068059 PK04_094061 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4481320.0 -496000.0 -0.54 4824160.0 -555000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C22 compound treatment 4737360.0 -654650.625 -0.723853969452549 -0.88 -0.9184 3186453 PK04_094062 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4787600.0 -190000.0 -0.21 4789360.0 -590000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C23 compound treatment 4936960.0 -455050.625 -0.50315418427671 -0.9341 -0.9753 3186454 PK04_094063 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCC(O)CO 4335040.0 -643000.0 -0.7 4969920.0 -410000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 C24 compound treatment 4766600.0 -625410.625 -0.691522998918774 -1.1656 -0.9088 3068060 PK04_094064 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 4716680.0 -261000.0 -0.29 4341680.0 -1040000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D01 compound treatment 2379520.0 -3012490.625 -3.33094205301468 -5.2862 -0.9979 3186455 PK04_094065 CN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 2334200.0 -2640000.0 -2.89 2459760.0 -2920000.0 -2.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D02 compound treatment 3407640.0 -1984370.625 -2.19413913149672 -3.8175 -0.9996 3000713 PK04_094066 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 2887880.0 -2090000.0 -2.29 3257720.0 -2120000.0 -2.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D03 compound treatment 2512920.0 -2879090.625 -3.18344029278193 -4.5847 -0.9757 3186456 PK04_094067 CCCN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 2293120.0 -2680000.0 -2.94 3568320.0 -1810000.0 -1.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D04 compound treatment 3577760.0 -1814250.625 -2.00603568733784 -3.2298 -0.9979 3089658 PK04_094068 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 3415080.0 -1560000.0 -1.71 3509240.0 -1870000.0 -1.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D05 compound treatment 4296120.0 -1095890.625 -1.21173760277413 -2.7499 -0.9701 3068061 PK04_094069 CCCN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 3685960.0 -1290000.0 -1.41 3250480.0 -2130000.0 -2.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D06 compound treatment 3686520.0 -1705490.625 -1.88577863004463 -3.0145 -0.9965 3089659 PK04_094070 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 3570320.0 -1410000.0 -1.54 3591520.0 -1790000.0 -1.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D07 compound treatment 3098040.0 -2293970.625 -2.53646705479552 -3.5923 -0.9849 3186457 PK04_094071 CCCN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 3474600.0 -1500000.0 -1.65 3347240.0 -2030000.0 -2.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D08 compound treatment 4401800.0 -990210.625 -1.09488613334836 -1.7212 -0.9936 3089664 PK04_094072 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 4018480.0 -959000.0 -1.05 4546520.0 -833000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D09 compound treatment 3782600.0 -1609410.625 -1.77954197994596 -2.0457 -0.9338 3068062 PK04_094073 CCCN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 3992520.0 -985000.0 -1.08 4696960.0 -683000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D10 compound treatment 2381600.0 -3010410.625 -3.32864217549381 -5.0164 -0.993 3000714 PK04_094074 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 2354360.0 -2620000.0 -2.87 2901160.0 -2480000.0 -2.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D11 mock treatment 5800840.0 408829.375 0.452046869920203 -0.0621 -0.0794 5045360.0 67800.0 0.07 4748000.0 -632000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D12 mock treatment 5393800.0 1789.375 0.00197853045139788 0.4356 0.6463 5054080.0 76500.0 0.08 6045960.0 666000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D13 compound treatment 3388360.0 -2003650.625 -2.21545722697864 -3.4048 -0.9797 3186504 PK04_094075 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 2891880.0 -2090000.0 -2.28 3986840.0 -1390000.0 -1.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D14 compound treatment 4457040.0 -934970.625 -1.03380669380371 -1.3466 -0.9341 3089660 PK04_094076 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 4121480.0 -856000.0 -0.94 5019720.0 -360000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D15 mock treatment 5315000.0 -77010.625 -0.0851514448585026 0.0811 0.2649 4921120.0 -56500.0 -0.06 5665960.0 286000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D16 mock treatment 5279160.0 -112850.625 -0.124780103679655 -0.4443 -0.7866 4483560.0 -494000.0 -0.54 5276200.0 -103000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D17 compound treatment 3479040.0 -1912970.625 -2.11519141275146 -3.4349 -0.9918 3186505 PK04_094077 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 2960960.0 -2020000.0 -2.21 3759600.0 -1620000.0 -1.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D18 compound treatment 4188400.0 -1203610.625 -1.3308447213069 -2.7394 -0.9937 3000715 PK04_094078 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 3438120.0 -1540000.0 -1.69 3657720.0 -1720000.0 -1.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D19 compound treatment 4354600.0 -1037410.625 -1.14707566170658 -1.6474 -0.9895 3068063 PK04_094079 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(Cc5ccccc5)C3=O 4201720.0 -776000.0 -0.85 4526000.0 -854000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D20 compound treatment 4119040.0 -1272970.625 -1.40753679094516 -2.0263 -0.9895 3089662 PK04_094080 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 4052120.0 -925000.0 -1.01 4294840.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D21 compound treatment 2734840.0 -2657170.625 -2.93806105267059 -4.5015 -0.9935 3186506 PK04_094081 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 2559960.0 -2420000.0 -2.65 3176320.0 -2200000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D22 compound treatment 3899040.0 -1492970.625 -1.65079306719107 -2.4179 -0.9756 3000716 PK04_094082 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 4106680.0 -871000.0 -0.95 3801760.0 -1580000.0 -1.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D23 compound treatment 2755720.0 -2636290.625 -2.91497382063416 -4.6503 -0.9982 3068064 PK04_094083 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 2616480.0 -2360000.0 -2.59 2834760.0 -2540000.0 -2.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 D24 compound treatment 569280.0 -4822730.625 -5.33254315079379 -8.8635 -0.9996 3000811 PK04_094084 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 410280.0 -4570000.0 -5.0 379680.0 -5000000.0 -5.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E01 mock treatment 4781280.0 -610730.625 -0.675291171031092 -1.4838 -0.9833 4216720.0 -761000.0 -0.83 4321880.0 -1060000.0 -1.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E02 mock treatment 5067640.0 -324370.625 -0.358659956186637 -0.5765 -0.9841 4621400.0 -356000.0 -0.39 5130560.0 -249000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E03 compound treatment 4892480.0 -499530.625 -0.552336180492248 -1.5974 -0.9284 3186507 PK04_094085 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4257640.0 -720000.0 -0.79 3958520.0 -1420000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E04 compound treatment 4198520.0 -1193490.625 -1.31965493259959 -2.3182 -0.9704 3186508 PK04_094086 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 4118880.0 -859000.0 -0.94 3630560.0 -1750000.0 -1.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E05 compound treatment 5109920.0 -282090.625 -0.311910522733558 0.0139 0.0353 3068065 PK04_094087 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCC(O)CO 5102840.0 125000.0 0.14 5577680.0 198000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E06 compound treatment 4287720.0 -1104290.625 -1.22102556968534 -1.6432 -0.9104 3186509 PK04_094088 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4666880.0 -311000.0 -0.34 4099320.0 -1280000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E07 compound treatment 2358400.0 -3033610.625 -3.35429465553428 -5.2517 -0.9958 3068066 PK04_094089 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 2534680.0 -2440000.0 -2.68 2323800.0 -3060000.0 -3.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E08 compound treatment 5540480.0 148469.375 0.164164124086629 -0.1554 -0.4422 3186510 PK04_094090 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 4746680.0 -231000.0 -0.25 5199800.0 -180000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E09 mock treatment 6247360.0 855349.375 0.945768653871685 0.5438 0.5749 4964800.0 -12800.0 -0.01 5389640.0 10100.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E10 mock treatment 6226080.0 834069.375 0.922239137696625 0.6653 0.7102 5098480.0 121000.0 0.13 5476960.0 97400.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E11 compound treatment 2238960.0 -3153050.625 -3.48636069932888 -5.451 -0.9947 3186511 PK04_094091 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 2010960.0 -2970000.0 -3.25 2683000.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E12 compound treatment 5858120.0 466109.375 0.515381958571867 1.0554 0.973 3068067 PK04_094092 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCC(O)CO 5720600.0 743000.0 0.81 5876760.0 497000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E13 compound treatment 4903560.0 -488450.625 -0.540084909852226 -0.9157 -0.9152 3186512 PK04_094093 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 4239760.0 -738000.0 -0.81 5142360.0 -237000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E14 compound treatment 5136000.0 -256010.625 -0.283073596894951 -0.2253 -0.7675 3068068 PK04_094094 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 4917880.0 -59700.0 -0.07 5337960.0 -41600.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E15 compound treatment 5717320.0 325309.375 0.359697941774481 0.4444 0.6708 3186513 PK04_094095 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 4858200.0 -119000.0 -0.13 5918400.0 539000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E16 compound treatment 5948120.0 556109.375 0.614895889763378 0.2808 0.388 3068069 PK04_094096 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4679680.0 -298000.0 -0.33 5576480.0 197000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E17 mock treatment 5489280.0 97269.375 0.107551754342125 -0.4506 -0.6459 4755760.0 -222000.0 -0.24 4736720.0 -643000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E18 mock treatment 5206120.0 -185890.625 -0.205541187393299 -0.2914 -0.9865 4830840.0 -147000.0 -0.16 5241640.0 -138000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E19 compound treatment 5762320.0 370309.375 0.409454907370237 0.6047 0.9724 3186514 PK04_094097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCC(O)CO 5349480.0 372000.0 0.41 5609280.0 230000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E20 compound treatment 1641280.0 -3750730.625 -4.14722165926824 -6.8492 -0.999 3186515 PK04_094098 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1333080.0 -3640000.0 -3.99 1667960.0 -3710000.0 -3.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E21 compound treatment 2362680.0 -3029330.625 -3.34956221525095 -5.5064 -0.9992 3068070 PK04_094099 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2102800.0 -2870000.0 -3.15 2350720.0 -3030000.0 -3.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E22 compound treatment 3656520.0 -1735490.625 -1.9189499404418 -3.429 -0.9997 3186516 PK04_094100 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 3110720.0 -1870000.0 -2.04 3410720.0 -1970000.0 -1.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E23 compound treatment 4611600.0 -780410.625 -0.862908102637487 -1.5038 -0.9996 3068071 PK04_094101 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCOCC4 4156560.0 -821000.0 -0.9 4539880.0 -840000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 E24 compound treatment 2946840.0 -2445170.625 -2.70365045919726 -4.4851 -0.996 3186517 PK04_094102 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 2421640.0 -2560000.0 -2.8 3121960.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F01 mock treatment 4615360.0 -776650.625 -0.858750631734375 -1.0653 -0.918 4301000.0 -677000.0 -0.74 5134880.0 -245000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F02 mock treatment 5278320.0 -113690.625 -0.125708900370776 -0.6846 -0.8601 4340880.0 -637000.0 -0.7 5018000.0 -362000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F03 compound treatment 2786880.0 -2605130.625 -2.88051988623497 -4.161 -0.9642 3068072 PK04_094103 CN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 2367360.0 -2610000.0 -2.86 3916760.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F04 compound treatment 926720.0 -4465290.625 -4.93731804451497 -8.3324 -0.9998 3000813 PK04_094104 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 688520.0 -4290000.0 -4.7 598880.0 -4780000.0 -4.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F05 compound treatment 4854520.0 -537490.625 -0.594308945248134 -1.4113 -0.8655 3186518 PK04_094105 CN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 4630640.0 -347000.0 -0.38 3914560.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F06 compound treatment 559320.0 -4832690.625 -5.34355602584565 -8.6686 -0.9983 3000814 PK04_094106 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 746920.0 -4230000.0 -4.63 359760.0 -5020000.0 -5.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F07 compound treatment 2316920.0 -3075090.625 -3.40015952071011 -5.7137 -0.9997 3186519 PK04_094107 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 2062520.0 -2920000.0 -3.19 2087440.0 -3290000.0 -3.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F08 compound treatment 2863360.0 -2528650.625 -2.79595515892912 -4.6388 -0.9992 3089667 PK04_094108 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 2666120.0 -2310000.0 -2.53 2681840.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F09 mock treatment 5841880.0 449869.375 0.497425222543532 0.6013 0.8171 5472840.0 495000.0 0.54 5381240.0 1690.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F10 mock treatment 5606520.0 214509.375 0.237185235374266 0.0837 0.2598 4801120.0 -176000.0 -0.19 5480200.0 101000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F11 compound treatment 4333280.0 -1058730.625 -1.1706494062955 -2.6748 -0.9849 3068073 PK04_094109 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 3466280.0 -1510000.0 -1.66 3578880.0 -1800000.0 -1.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F12 compound treatment 2362800.0 -3029210.625 -3.34942953000937 -5.1402 -0.9957 3089654 PK04_094110 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 2504680.0 -2470000.0 -2.71 2544200.0 -2840000.0 -2.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F13 compound treatment 4107440.0 -1284570.625 -1.4203630309654 -2.0485 -0.9897 3186520 PK04_094111 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 4039640.0 -938000.0 -1.03 4282960.0 -1100000.0 -1.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F14 compound treatment 417080.0 -4974930.625 -5.5008322655421 -8.9637 -0.999 3089708 PK04_094112 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 446160.0 -4530000.0 -4.96 335320.0 -5040000.0 -5.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F15 compound treatment 2517120.0 -2874890.625 -3.17879630932632 -5.1525 -0.9972 3186521 PK04_094113 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 2161560.0 -2820000.0 -3.08 2727280.0 -2650000.0 -2.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F16 compound treatment 1321920.0 -4070090.625 -4.50034131554958 -7.6252 -0.9999 3000817 PK04_094114 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1012280.0 -3970000.0 -4.34 1030720.0 -4350000.0 -4.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F17 mock treatment 5724320.0 332309.375 0.367437914200488 0.6728 0.9114 5146360.0 169000.0 0.18 5990360.0 611000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F18 mock treatment 5840720.0 448709.375 0.496142598541508 0.3564 0.6002 4829640.0 -148000.0 -0.16 5661640.0 282000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F19 compound treatment 2447520.0 -2944490.625 -3.25575374944776 -5.5693 -0.9999 3068074 PK04_094115 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 2019360.0 -2960000.0 -3.24 2239760.0 -3140000.0 -3.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F20 compound treatment 1272160.0 -4119850.625 -4.55536146239502 -7.5959 -0.9996 3089709 PK04_094116 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1044320.0 -3930000.0 -4.31 1101200.0 -4280000.0 -4.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F21 compound treatment 2776160.0 -2615850.625 -2.89237310115022 -4.5327 -0.9965 3186522 PK04_094117 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(Cc5ccccc5)C3=O 2829760.0 -2150000.0 -2.35 2782480.0 -2600000.0 -2.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F22 compound treatment 2653440.0 -2738570.625 -3.02806587488158 -4.9224 -0.9982 3000821 PK04_094118 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 2344960.0 -2630000.0 -2.88 2774120.0 -2610000.0 -2.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F23 compound treatment 3329440.0 -2062570.625 -2.28060568059868 -4.6914 -0.9938 3186523 PK04_094119 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 2306760.0 -2670000.0 -2.92 2469760.0 -2910000.0 -2.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 F24 compound treatment 365960.0 -5026050.625 -5.55735617845888 -9.0277 -0.9989 3089711 PK04_094120 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 340440.0 -4640000.0 -5.08 396600.0 -4980000.0 -5.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G01 compound treatment 3955960.0 -1436050.625 -1.58785603426418 -2.7948 -0.9999 3068075 PK04_094121 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCOCC4 3470720.0 -1510000.0 -1.65 3782600.0 -1600000.0 -1.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G02 compound treatment 5124160.0 -267850.625 -0.296165207398368 -0.6725 -0.9837 3186524 PK04_094122 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 4549640.0 -428000.0 -0.47 4980920.0 -399000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G03 mock treatment 5109560.0 -282450.625 -0.312308578458324 -0.4706 -0.6022 5149560.0 172000.0 0.19 4690800.0 -689000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G04 mock treatment 4454000.0 -938010.625 -1.03716805325729 -0.797 -0.6999 5080760.0 103000.0 0.11 4924840.0 -455000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G05 compound treatment 5801760.0 409749.375 0.45306412343905 0.1705 0.334 3186575 PK04_094123 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 5039280.0 61700.0 0.07 5155040.0 -225000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G06 compound treatment 5101200.0 -290810.625 -0.321552316955669 -1.1305 -0.861 3186576 PK04_094124 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 4573000.0 -405000.0 -0.44 4190320.0 -1190000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G07 compound treatment 5458040.0 66029.375 0.073009363115205 -0.3227 -0.6835 3068110 PK04_094125 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCOCC4 4775400.0 -202000.0 -0.22 4970560.0 -409000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G08 compound treatment 5388560.0 -3450.625 -0.00381539176464118 0.0671 0.1154 3186577 PK04_094126 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 5403720.0 426000.0 0.47 5034080.0 -345000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G09 compound treatment 3077720.0 -2314290.625 -2.55893508903787 -3.9343 -0.9805 3068111 PK04_094127 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3489920.0 -1490000.0 -1.63 2762680.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G10 compound treatment 5258680.0 -133330.625 -0.147425051577457 0.0907 0.2552 3186578 PK04_094128 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 4960800.0 -16800.0 -0.02 5701280.0 322000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G11 compound treatment 4328960.0 -1063050.625 -1.17542607499269 -1.9568 -0.9995 3186579 PK04_094129 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 3981200.0 -996000.0 -1.09 4260800.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G12 compound treatment 5812800.0 420789.375 0.465271165665209 0.8665 0.8861 3068112 PK04_094130 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 5741760.0 764000.0 0.84 5577520.0 198000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G13 compound treatment 6057680.0 665669.375 0.736037515333843 1.0226 0.9788 3186580 PK04_094131 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCCN3CCOCC3 5373840.0 396000.0 0.43 5978520.0 599000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G14 compound treatment 5276240.0 -115770.625 -0.128008777891646 -0.1429 -0.7953 3186581 PK04_094132 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 4862600.0 -115000.0 -0.13 5385960.0 6410.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G15 compound treatment 5763240.0 371229.375 0.410472160889083 0.8665 0.895 3068113 PK04_094133 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 5205760.0 228000.0 0.25 6217080.0 838000.0 0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G16 compound treatment 3196200.0 -2195810.625 -2.42793052717598 -3.866 -0.9954 3186582 PK04_094134 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 2845560.0 -2130000.0 -2.33 3453080.0 -1930000.0 -1.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G17 compound treatment 5913080.0 521069.375 0.576151799219483 0.8076 0.9159 3186583 PK04_094135 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 5564480.0 587000.0 0.64 5558760.0 179000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G18 compound treatment 5182960.0 -209050.625 -0.231149439019914 -1.1115 -0.9079 3068114 PK04_094136 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4270440.0 -707000.0 -0.77 4463240.0 -916000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G19 mock treatment 5514080.0 122069.375 0.134973370937119 -0.0064 -0.0358 4875720.0 -102000.0 -0.11 5345160.0 -34400.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G20 mock treatment 5321800.0 -70210.625 -0.0776326145018106 0.3894 0.6978 5418080.0 441000.0 0.48 5648360.0 269000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G21 compound treatment 4085960.0 -1306050.625 -1.44411368920977 -3.1195 -0.9692 3186584 PK04_094137 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCCCC4 2743560.0 -2230000.0 -2.45 3872480.0 -1510000.0 -1.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G22 compound treatment 5426240.0 34229.375 0.0378477740942046 -0.108 -0.645 3068115 PK04_094138 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4851480.0 -126000.0 -0.14 5293000.0 -86500.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G23 compound treatment 5193520.0 -198490.625 -0.21947313776011 -1.0644 -0.8792 3186585 PK04_094139 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4033400.0 -944000.0 -1.03 4791440.0 -588000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 G24 compound treatment 4819320.0 -572690.625 -0.63322994944748 -0.9586 -0.9752 3186586 PK04_094140 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCc3ccccc3 4383000.0 -595000.0 -0.65 5004840.0 -375000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H01 compound treatment 2406800.0 -2985210.625 -3.30077827476018 -5.6375 -0.9999 3068116 PK04_094141 CCCN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 2051240.0 -2930000.0 -3.2 2132280.0 -3250000.0 -3.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H02 compound treatment 2709440.0 -2682570.625 -2.96614609547353 -5.1838 -1.0 3000914 PK04_094142 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 2256680.0 -2720000.0 -2.98 2357600.0 -3020000.0 -3.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H03 mock treatment 5536400.0 144389.375 0.159652825872614 0.1149 0.539 4906120.0 -71500.0 -0.08 5496720.0 117000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H04 mock treatment 5437200.0 45189.375 0.0499663594926375 0.3023 0.7517 5333960.0 356000.0 0.39 5462680.0 83100.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H05 compound treatment 5025840.0 -366170.625 -0.404878648673361 -1.3091 -0.8826 3068117 PK04_094143 CCCN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 4481720.0 -496000.0 -0.54 4064680.0 -1310000.0 -1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H06 compound treatment 2381760.0 -3010250.625 -3.32846526183835 -5.3355 -0.9857 3089723 PK04_094144 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 2832280.0 -2150000.0 -2.35 1828640.0 -3550000.0 -3.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H07 compound treatment 3232720.0 -2159290.625 -2.38754998531916 -2.7935 -0.8464 3186589 PK04_094145 CN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 4813920.0 -164000.0 -0.18 3116000.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H08 compound treatment 2394600.0 -2997410.625 -3.31426794098837 -3.8824 -0.8641 3089724 PK04_094146 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 4608920.0 -369000.0 -0.4 2383680.0 -3000000.0 -3.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H09 compound treatment 4674680.0 -717330.625 -0.793159893975704 -1.092 -0.9512 3186590 PK04_094147 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(C(=O)c5ccccc5)C3=O 4665280.0 -312000.0 -0.34 4626040.0 -754000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H10 compound treatment 3752840.0 -1639170.625 -1.81244791985995 -3.0395 -0.9965 3000917 PK04_094148 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 3560120.0 -1420000.0 -1.55 3486440.0 -1890000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H11 compound treatment 3481560.0 -1910450.625 -2.11240502267809 -3.1206 -0.9922 3068119 PK04_094149 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 3414000.0 -1560000.0 -1.71 3804800.0 -1570000.0 -1.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H12 compound treatment 2980000.0 -2412010.625 -2.66698510410492 -5.0876 -0.9949 3089768 PK04_094150 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1917640.0 -3060000.0 -3.35 2595560.0 -2780000.0 -2.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H13 compound treatment 3949440.0 -1442570.625 -1.59506526572383 -2.6345 -0.9984 3186593 PK04_094151 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 3547560.0 -1430000.0 -1.57 3982600.0 -1400000.0 -1.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H14 compound treatment 5878480.0 486469.375 0.53789422122808 0.193 0.261 3089763 PK04_094152 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 4570440.0 -407000.0 -0.45 5620960.0 241000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H15 compound treatment 4038400.0 -1353610.625 -1.49670127329275 -2.7415 -0.9986 3186594 PK04_094153 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 3427960.0 -1550000.0 -1.7 3830440.0 -1550000.0 -1.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H16 compound treatment 3345360.0 -2046650.625 -2.26300277188125 -4.1456 -0.9989 3089764 PK04_094154 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 2658040.0 -2320000.0 -2.54 3010760.0 -2370000.0 -2.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H17 compound treatment 5195040.0 -196970.625 -0.217792458033321 -0.2724 -0.9647 3068121 PK04_094155 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(C(=O)c5ccccc5)C3=O 4865600.0 -112000.0 -0.12 5248560.0 -131000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H18 compound treatment 3987000.0 -1405010.625 -1.55353478510657 -2.9719 -0.9886 3000919 PK04_094156 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 3598640.0 -1380000.0 -1.51 3303200.0 -2080000.0 -2.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H19 mock treatment 5877800.0 485789.375 0.537142338192411 0.8544 0.9008 5144320.0 167000.0 0.18 6136960.0 757000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H20 mock treatment 4372280.0 -1019730.625 -1.12752670277918 -0.05 -0.0364 5627280.0 650000.0 0.71 5707840.0 328000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H21 compound treatment 4329040.0 -1062970.625 -1.17533761816497 -2.2173 -0.9982 3068122 PK04_094157 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 3736120.0 -1240000.0 -1.36 4078560.0 -1300000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H22 compound treatment 2379480.0 -3012530.625 -3.33098628142854 -5.7505 -0.9967 3089766 PK04_094158 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 2251080.0 -2730000.0 -2.99 1749160.0 -3630000.0 -3.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H23 compound treatment 4100280.0 -1291730.625 -1.42827991704686 -1.79 -0.9644 3068123 PK04_094159 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 4268240.0 -709000.0 -0.78 4487440.0 -892000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 H24 compound treatment 3881640.0 -1510370.625 -1.67003242722143 -2.7534 -0.9766 3089769 PK04_094160 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 3176720.0 -1800000.0 -1.97 4256720.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I01 compound treatment 3411200.0 -1980810.625 -2.19020280266292 -3.9443 -0.999 3186651 PK04_094161 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 2767480.0 -2210000.0 -2.42 3166280.0 -2210000.0 -2.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I02 compound treatment 4136080.0 -1255930.625 -1.38869548663957 -1.882 -0.9812 3068124 PK04_094162 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 4127720.0 -850000.0 -0.93 4442600.0 -937000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I03 compound treatment 4281160.0 -1110850.625 -1.22827902955885 -1.8056 -0.9768 3186652 PK04_094163 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 3901680.0 -1080000.0 -1.18 4661240.0 -718000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I04 compound treatment 3804160.0 -1587850.625 -1.75570286487386 -2.2711 -0.9712 3068125 PK04_094164 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCc4ccccc4 4058800.0 -919000.0 -1.01 4212000.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I05 mock treatment 5571520.0 179509.375 0.198485373244234 0.0896 0.2736 5124720.0 147000.0 0.16 5175800.0 -204000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I06 mock treatment 5111280.0 -280730.625 -0.31040675666222 -0.2083 -0.6044 4860600.0 -117000.0 -0.13 5456960.0 77400.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I07 compound treatment 5026640.0 -365370.625 -0.403994080396103 -0.9934 -0.7833 3186653 PK04_094165 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 4867600.0 -110000.0 -0.12 4187680.0 -1190000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I08 compound treatment 5491040.0 99029.375 0.109497804552092 0.607 0.8992 3068126 PK04_094166 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCC(O)CO 5416520.0 439000.0 0.48 5839080.0 460000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I09 compound treatment 5964600.0 572589.375 0.63311799627489 0.5857 0.8353 3186654 PK04_094167 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 5238760.0 261000.0 0.29 5474560.0 95000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I10 compound treatment 3653000.0 -1739010.625 -1.92284204086173 -2.2396 -0.9141 3068572 PK04_094168 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 4488400.0 -489000.0 -0.54 3964000.0 -1420000.0 -1.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I11 compound treatment 4609520.0 -782490.625 -0.865207980158357 -0.7445 -0.8082 3186655 PK04_094169 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4848560.0 -129000.0 -0.14 5097520.0 -282000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I12 compound treatment 2234440.0 -3157570.625 -3.49135851009539 -5.575 -0.9973 3186656 PK04_094170 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 2313520.0 -2660000.0 -2.92 2143680.0 -3240000.0 -3.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I13 compound treatment 3192320.0 -2199690.625 -2.43222068332068 -4.0232 -0.9994 3068573 PK04_094171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCCCC4 2921160.0 -2060000.0 -2.25 3103560.0 -2280000.0 -2.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I14 compound treatment 4444400.0 -947610.625 -1.04778287258438 -1.7699 -0.9997 3186657 PK04_094172 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 4074160.0 -903000.0 -0.99 4354800.0 -1020000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I15 compound treatment 3848360.0 -1543650.625 -1.70683046755536 -2.953 -1.0 3068574 PK04_094173 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 3418160.0 -1560000.0 -1.71 3685440.0 -1690000.0 -1.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I16 compound treatment 2547160.0 -2844850.625 -3.14558077051529 -5.1971 -0.9982 3186658 PK04_094174 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 2137080.0 -2840000.0 -3.11 2643960.0 -2740000.0 -2.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I17 compound treatment 3341320.0 -2050690.625 -2.2674698416814 -4.0591 -0.9997 3186659 PK04_094175 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 2791640.0 -2190000.0 -2.39 3018840.0 -2360000.0 -2.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I18 compound treatment 2833120.0 -2558890.625 -2.82939183980946 -4.7581 -0.9966 3068575 PK04_094176 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 2260920.0 -2720000.0 -2.98 2951480.0 -2430000.0 -2.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I19 compound treatment 5674280.0 282269.375 0.312108168458008 0.2776 0.7512 3186660 PK04_094177 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 5156520.0 179000.0 0.2 5352360.0 -27200.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I20 compound treatment 2777600.0 -2614410.625 -2.89078087825116 -4.4817 -0.9966 3068577 PK04_094178 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 2769720.0 -2210000.0 -2.42 2934440.0 -2450000.0 -2.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I21 mock treatment 5397920.0 5909.375 0.00653405707927592 0.0688 0.1103 5428280.0 451000.0 0.49 4999920.0 -380000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I22 mock treatment 5692520.0 300509.375 0.332276325179487 0.0198 0.0397 5039200.0 61600.0 0.07 5015360.0 -364000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I23 compound treatment 4426600.0 -965410.625 -1.06746451675337 -0.9443 -0.8247 3186661 PK04_094179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 4783800.0 -194000.0 -0.21 5024920.0 -355000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 I24 compound treatment 2050920.0 -3341090.625 -3.69427847289835 -5.3049 -0.9773 3186662 PK04_094180 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1918480.0 -3060000.0 -3.35 3243160.0 -2140000.0 -2.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J01 compound treatment 4026320.0 -1365690.625 -1.51005825427935 -2.576 -0.9986 3068611 PK04_094181 CN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 3542280.0 -1440000.0 -1.57 4004520.0 -1380000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J02 compound treatment 2114400.0 -3277610.625 -3.62408798009794 -5.9158 -0.9987 3089770 PK04_094182 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 2052160.0 -2930000.0 -3.2 1973000.0 -3410000.0 -3.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J03 compound treatment 3117920.0 -2274090.625 -2.51448553310566 -4.033 -0.9974 3068612 PK04_094183 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 3052520.0 -1930000.0 -2.11 3025320.0 -2350000.0 -2.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J04 compound treatment 4280000.0 -1112010.625 -1.22956165356087 -1.9678 -0.9946 3001007 PK04_094184 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 3872400.0 -1110000.0 -1.21 4414600.0 -965000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J05 mock treatment 5644240.0 252229.375 0.278892629646975 0.5952 0.9897 5299480.0 322000.0 0.35 5777640.0 398000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J06 mock treatment 5166240.0 -225770.625 -0.249636916014604 0.202 0.408 5215520.0 238000.0 0.26 5717280.0 338000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J07 compound treatment 2259000.0 -3133010.625 -3.46420226398358 -5.0903 -0.9869 3186665 PK04_094185 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 2873560.0 -2100000.0 -2.3 2342080.0 -3040000.0 -3.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J08 compound treatment 4314520.0 -1077490.625 -1.1913925323972 -1.6809 -0.9466 3089771 PK04_094186 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 4518240.0 -459000.0 -0.5 4166880.0 -1210000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J09 compound treatment 3337720.0 -2054290.625 -2.27145039892906 -3.3788 -0.9602 3186666 PK04_094187 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 3924240.0 -1050000.0 -1.15 2960920.0 -2420000.0 -2.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J10 compound treatment 4046560.0 -1345450.625 -1.48767867686472 -2.215 -0.9912 3089776 PK04_094188 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 4000760.0 -977000.0 -1.07 4105000.0 -1270000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J11 compound treatment 5219240.0 -172770.625 -0.19103426764627 -0.8459 -0.8586 3068615 PK04_094189 CCCN1C(=O)[C@]2(COC(=N2)c3ccc(OCCCO)cc3)Cc4ccccc14 4621720.0 -356000.0 -0.39 4498320.0 -881000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J12 compound treatment 3165840.0 -2226170.625 -2.46149989329791 -4.7719 -0.9964 3001011 PK04_094190 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 2203240.0 -2770000.0 -3.04 2624040.0 -2760000.0 -2.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J13 compound treatment 3375000.0 -2017010.625 -2.23022951720884 -3.8443 -0.9988 3068616 PK04_094191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 2832600.0 -2140000.0 -2.35 3307640.0 -2070000.0 -2.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J14 compound treatment 4320320.0 -1071690.625 -1.18497941238708 -1.905 -0.9914 3089772 PK04_094192 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 3864640.0 -1110000.0 -1.22 4487040.0 -893000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J15 compound treatment 2451800.0 -2940210.625 -3.25102130916443 -5.4117 -0.9993 3068617 PK04_094193 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 2096560.0 -2880000.0 -3.16 2422880.0 -2960000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J16 compound treatment 4852560.0 -539450.625 -0.596476137527416 -2.1047 -0.8158 3089773 PK04_094194 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 2755640.0 -2220000.0 -2.43 4766000.0 -614000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J17 compound treatment 4105280.0 -1286730.625 -1.42275136531399 -2.2696 -0.9977 3186732 PK04_094195 CN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 3789520.0 -1190000.0 -1.3 4176600.0 -1200000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J18 compound treatment 3542560.0 -1849450.625 -2.04495669153718 -3.5859 -0.9983 3089774 PK04_094196 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 3209960.0 -1770000.0 -1.94 3157160.0 -2220000.0 -2.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J19 compound treatment 3749760.0 -1642250.625 -1.81585350772739 -3.3211 -0.9991 3186733 PK04_094197 CCCN1C(=O)[C@@]2(Cc3ccccc13)N=C(O[C@H]2c4ccccc4)c5ccc(OCCCO)cc5 3137000.0 -1840000.0 -2.02 3465600.0 -1910000.0 -1.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J20 compound treatment 3905520.0 -1486490.625 -1.64362806414529 -2.8817 -0.9998 3089775 PK04_094198 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 3479880.0 -1500000.0 -1.64 3678240.0 -1700000.0 -1.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J21 mock treatment 5960600.0 568589.375 0.628695154888601 0.62 0.8289 5345680.0 368000.0 0.4 5421520.0 42000.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J22 mock treatment 5231080.0 -160930.625 -0.177942657142853 -0.4734 -0.3666 5456440.0 479000.0 0.52 4217280.0 -1160000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J23 compound treatment 5013200.0 -378810.625 -0.418854827454035 -0.1281 -0.2892 3068619 PK04_094199 COC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 5092440.0 115000.0 0.13 5450400.0 70900.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 J24 compound treatment 2287000.0 -3105010.625 -3.43324237427955 -5.2103 -0.9904 3089828 PK04_094200 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 2096360.0 -2880000.0 -3.16 2952320.0 -2430000.0 -2.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K01 compound treatment 2154160.0 -3237850.625 -3.58012493671822 -5.7899 -0.9987 3068620 PK04_094201 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1990320.0 -2990000.0 -3.27 2214080.0 -3170000.0 -3.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K02 compound treatment 3022560.0 -2369450.625 -2.6199260717548 -4.5186 -0.998 3186736 PK04_094202 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 2783280.0 -2190000.0 -2.4 2586120.0 -2790000.0 -2.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K03 compound treatment 3416000.0 -1976010.625 -2.18489539299938 -3.5339 -0.9717 3186737 PK04_094203 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 2637640.0 -2340000.0 -2.56 4010880.0 -1370000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K04 compound treatment 5672200.0 280189.375 0.309808290937137 0.0728 0.2079 3068660 PK04_094204 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 4957760.0 -19800.0 -0.02 5218160.0 -161000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K05 compound treatment 5212800.0 -179210.625 -0.198155042278196 -0.2903 -0.7037 3186738 PK04_094205 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 5026200.0 48600.0 0.05 5023000.0 -357000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K06 compound treatment 5655720.0 263709.375 0.291586184425625 0.1056 0.3088 3068661 PK04_094206 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCOCC4 5032200.0 54600.0 0.06 5211680.0 -168000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K07 mock treatment 5302800.0 -89210.625 -0.0986411110866851 0.0181 0.0201 5611040.0 633000.0 0.69 4817800.0 -562000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K08 mock treatment 5396800.0 4789.375 0.0052956614911149 0.2797 0.7744 5277040.0 299000.0 0.33 5530160.0 151000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K09 compound treatment 3533480.0 -1858530.625 -2.05499654148406 -3.5586 -0.9981 3186739 PK04_094207 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 3243840.0 -1730000.0 -1.9 3177360.0 -2200000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K10 compound treatment 5457640.0 65629.375 0.0725670789765761 0.2648 0.6497 3186740 PK04_094208 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 5343520.0 366000.0 0.4 5364880.0 -14700.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K11 compound treatment 2979040.0 -2412970.625 -2.66804658603763 -4.2834 -0.9984 3068664 PK04_094209 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 2784080.0 -2190000.0 -2.4 3039040.0 -2340000.0 -2.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K12 compound treatment 3729960.0 -1662050.625 -1.83774657258953 -2.6349 -0.9619 3186741 PK04_094210 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 4147000.0 -831000.0 -0.91 3569640.0 -1810000.0 -1.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K13 compound treatment 4433760.0 -958250.625 -1.05954763067191 -1.5386 -0.9093 3068666 PK04_094211 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4678640.0 -299000.0 -0.33 4106160.0 -1270000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K14 compound treatment 2138040.0 -3253970.625 -3.59794898750497 -5.7966 -0.9986 3186742 PK04_094212 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 2003240.0 -2970000.0 -3.26 2206080.0 -3170000.0 -3.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K15 mock treatment 5724520.0 332509.375 0.367659056269802 0.3778 0.5697 4777040.0 -201000.0 -0.22 5884000.0 504000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K16 mock treatment 5305880.0 -86130.625 -0.0952355232192423 -0.0599 -0.1467 4717440.0 -260000.0 -0.28 5654960.0 275000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K17 compound treatment 3432560.0 -1959450.625 -2.16658482966014 -3.2295 -0.9883 3186743 PK04_094213 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 3196560.0 -1780000.0 -1.95 3908120.0 -1470000.0 -1.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K18 compound treatment 2540080.0 -2851930.625 -3.15340919976902 -5.3309 -0.9994 3068667 PK04_094214 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 2300520.0 -2680000.0 -2.93 2242480.0 -3140000.0 -3.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K19 compound treatment 5192640.0 -199370.625 -0.220446162865094 -0.7002 -0.951 3186744 PK04_094215 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 4502240.0 -475000.0 -0.52 4909520.0 -470000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K20 compound treatment 3306880.0 -2085130.625 -2.30555050601735 -4.1036 -0.9979 3186745 PK04_094216 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 2947520.0 -2030000.0 -2.22 2809880.0 -2570000.0 -2.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K21 compound treatment 3496800.0 -1895210.625 -2.09555399699633 -3.4951 -0.9953 3068668 PK04_094217 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCCCC4 2959680.0 -2020000.0 -2.21 3637400.0 -1740000.0 -1.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K22 compound treatment 4161240.0 -1230770.625 -1.36087581431981 -2.1289 -0.9643 3186746 PK04_094218 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 3552800.0 -1420000.0 -1.56 4616080.0 -763000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K23 mock treatment 4878600.0 -513410.625 -0.567683440102672 -0.4968 -0.7969 4943000.0 -34600.0 -0.04 5125520.0 -254000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 K24 mock treatment 4761280.0 -630730.625 -0.697405377962539 -0.9597 -0.9702 4431640.0 -546000.0 -0.6 5013960.0 -366000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L01 compound treatment 4949080.0 -442930.625 -0.489752974876253 -0.8728 -0.9993 3068669 PK04_094219 CCOC(=O)N1C(N=C(N1C(=O)OCC)c2ccc(OCCCO)cc2)C(=O)OC 4492800.0 -485000.0 -0.53 4890160.0 -489000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L02 compound treatment 1583480.0 -3808530.625 -4.21113171730012 -6.3992 -0.9942 3001020 PK04_094220 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 2019560.0 -2960000.0 -3.24 1759280.0 -3620000.0 -3.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L03 compound treatment 4870520.0 -521490.625 -0.576617579702976 -1.0005 -0.9965 3068670 PK04_094221 COCCCNC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 4395080.0 -582000.0 -0.64 4863000.0 -517000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L04 compound treatment 1700120.0 -3691890.625 -4.08216166247592 -6.711 -0.9988 3089829 PK04_094222 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1399200.0 -3580000.0 -3.92 1769560.0 -3610000.0 -3.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L05 compound treatment 5916360.0 524349.375 0.57977852915624 0.3635 0.5905 3186813 PK04_094223 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)O 4868720.0 -109000.0 -0.12 5547920.0 168000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L06 compound treatment 3706480.0 -1685530.625 -1.86370865152704 -2.9952 -0.9948 3001022 PK04_094224 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 3627680.0 -1350000.0 -1.48 3540320.0 -1840000.0 -1.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L07 mock treatment 4485440.0 -906570.625 -1.00240451996105 -0.5465 -0.5213 5199920.0 222000.0 0.24 5192480.0 -187000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L08 mock treatment 5680280.0 288269.375 0.318742430537442 0.6751 0.9875 5406760.0 429000.0 0.47 5758720.0 379000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L09 compound treatment 5682840.0 290829.375 0.321573049024667 0.7332 0.9821 3067926 PK04_094225 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 5452520.0 475000.0 0.52 5806240.0 427000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L10 compound treatment 3735760.0 -1656250.625 -1.83133345257941 -2.6274 -0.989 3089768 PK04_094226 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 3783560.0 -1190000.0 -1.31 3972760.0 -1410000.0 -1.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L11 compound treatment 5585120.0 193109.375 0.213523033957618 0.8565 0.9209 3186815 PK04_094227 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 5631120.0 654000.0 0.72 5931800.0 552000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L12 compound treatment 3067000.0 -2325010.625 -2.57078830395312 -3.9196 -0.9953 3089830 PK04_094228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 3091080.0 -1890000.0 -2.07 3234960.0 -2140000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L13 compound treatment 5475280.0 83269.375 0.0920718094901122 0.5903 0.8833 3067927 PK04_094229 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCC(O)CO 5354920.0 377000.0 0.41 5894800.0 515000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L14 compound treatment 4563200.0 -828810.625 -0.916424483411588 -1.3169 -0.9284 3089831 PK04_094230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 4671760.0 -306000.0 -0.33 4353640.0 -1030000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L15 mock treatment 5576920.0 184909.375 0.204456209115725 0.8581 0.9185 5500240.0 523000.0 0.57 6086440.0 707000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L16 mock treatment 5712640.0 320629.375 0.354523217352523 0.5748 0.8636 5054280.0 76700.0 0.08 5934560.0 555000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L17 compound treatment 2490760.0 -2901250.625 -3.20794283406197 -5.3063 -0.9994 3067928 PK04_094231 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCc4ccccc4 2254520.0 -2720000.0 -2.98 2389520.0 -2990000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L18 compound treatment 3929120.0 -1462890.625 -1.61753329996618 -2.5471 -0.9967 3001180 PK04_094232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 3767920.0 -1210000.0 -1.32 3915280.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L19 compound treatment 5844600.0 452589.375 0.500432754686209 0.8296 0.981 3067929 PK04_094233 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCCN4CCOCC4 5300680.0 323000.0 0.35 5960080.0 581000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L20 compound treatment 4297360.0 -1094650.625 -1.21036652194438 -1.8591 -0.9924 3001092 PK04_094234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 3957440.0 -1020000.0 -1.12 4490200.0 -889000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L21 compound treatment 5055720.0 -336290.625 -0.371840023517779 -0.1617 -0.3431 3067930 PK04_094235 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCCCC4 4837200.0 -140000.0 -0.15 5624120.0 245000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L22 compound treatment 3681200.0 -1710810.625 -1.89166100908839 -3.191 -0.9998 3001093 PK04_094236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 3309080.0 -1670000.0 -1.83 3577960.0 -1800000.0 -1.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L23 mock treatment 5395680.0 3669.375 0.00405726590295388 0.2067 0.3409 4782600.0 -195000.0 -0.21 5944960.0 565000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 L24 mock treatment 4981800.0 -410210.625 -0.453574132336406 -0.8941 -0.9936 4520880.0 -457000.0 -0.5 4786800.0 -593000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M01 compound treatment 1782400.0 -3609610.625 -3.99118381515995 -6.4079 -0.9984 3067931 PK04_094237 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1723400.0 -3250000.0 -3.56 1848280.0 -3530000.0 -3.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M02 compound treatment 4402120.0 -989890.625 -1.09453230603746 -1.8038 -0.9786 3186821 PK04_094238 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 4292080.0 -685000.0 -0.75 4105040.0 -1270000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M03 compound treatment 3685440.0 -1706570.625 -1.88697279721893 -3.4067 -0.9994 3067933 PK04_094239 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 3190120.0 -1790000.0 -1.96 3330680.0 -2050000.0 -2.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M04 compound treatment 5346560.0 -45450.625 -0.0502552263206795 -0.1059 -0.9819 3186822 PK04_094240 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCCN3CCOCC3 4906760.0 -70800.0 -0.08 5324120.0 -55400.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M05 compound treatment 5331720.0 -60290.625 -0.066663967863813 0.3112 0.6418 3067934 PK04_094241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCCN4CCOCC4 5113720.0 136000.0 0.15 5834520.0 455000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M06 compound treatment 6378200.0 986189.375 1.09043979561721 1.4066 0.9591 3186823 PK04_094242 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 5745160.0 768000.0 0.84 5883040.0 503000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M07 compound treatment 2618640.0 -2773370.625 -3.0665445949423 -3.9182 -0.9307 3186824 PK04_094243 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4043160.0 -934000.0 -1.02 2692440.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M08 compound treatment 3456200.0 -1935810.625 -2.14044583706717 -4.491 -0.9924 3186825 PK04_094244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 2382560.0 -2600000.0 -2.84 2593160.0 -2790000.0 -2.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M09 mock treatment 5423000.0 30989.375 0.0342652725713102 0.3706 0.846 5305440.0 328000.0 0.36 5627280.0 248000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M10 mock treatment 5416320.0 24309.375 0.026879127456207 0.404 0.686 5508160.0 531000.0 0.58 5471000.0 91500.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M11 compound treatment 2210920.0 -3181090.625 -3.51736481744677 -5.1495 -0.9885 3067981 PK04_094245 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 2780400.0 -2200000.0 -2.41 2394640.0 -2980000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M12 compound treatment 5709160.0 317149.375 0.350675345346451 0.6125 0.9993 3186826 PK04_094246 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 5316640.0 339000.0 0.37 5717200.0 338000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M13 mock treatment 5784200.0 392189.375 0.43364784975324 0.7238 0.9354 5175840.0 198000.0 0.22 5980360.0 601000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M14 mock treatment 6295800.0 903789.375 0.999329263059649 1.0735 0.8916 5186280.0 209000.0 0.23 6008760.0 629000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M15 compound treatment 2181240.0 -3210770.625 -3.55018230053304 -5.5094 -0.9961 3067982 PK04_094247 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 2354480.0 -2620000.0 -2.87 2270880.0 -3110000.0 -3.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M16 compound treatment 2572080.0 -2819930.625 -3.11802646867871 -5.3063 -0.9999 3186827 PK04_094248 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 2232080.0 -2750000.0 -3.01 2324400.0 -3060000.0 -3.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M17 compound treatment 2588480.0 -2803530.625 -3.09989281899492 -4.3605 -0.9844 3067983 PK04_094249 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 3147360.0 -1830000.0 -2.0 2939920.0 -2440000.0 -2.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M18 compound treatment 3554080.0 -1837930.625 -2.03221890834467 -2.1598 -0.9074 3186828 PK04_094250 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 4020600.0 -957000.0 -1.05 4721320.0 -658000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M19 compound treatment 3638320.0 -1753690.625 -1.93907386874941 -3.3992 -0.995 3186829 PK04_094251 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 3393560.0 -1580000.0 -1.73 3173560.0 -2210000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M20 compound treatment 4568000.0 -824010.625 -0.911117073748041 -1.4844 -0.9794 3067984 PK04_094252 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 4412880.0 -565000.0 -0.62 4341760.0 -1040000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M21 compound treatment 5362400.0 -29610.625 -0.0327407744309736 -0.3702 -0.6649 3186907 PK04_094253 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 4926960.0 -50600.0 -0.06 4828520.0 -551000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M22 compound treatment 2632520.0 -2759490.625 -3.05119733533187 -4.9783 -0.9984 3067985 PK04_094254 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 2548480.0 -2430000.0 -2.66 2478520.0 -2900000.0 -2.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M23 compound treatment 3385520.0 -2006490.625 -2.2185974443629 -3.9524 -0.9989 3186908 PK04_094255 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 2753200.0 -2220000.0 -2.44 3196240.0 -2180000.0 -2.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 M24 compound treatment 2100520.0 -3291490.625 -3.63943523970836 -6.054 -0.9996 3186909 PK04_094256 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1878120.0 -3100000.0 -3.39 1939760.0 -3440000.0 -3.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N01 compound treatment 4919640.0 -472370.625 -0.522305087479343 -0.5035 -0.6067 3067986 PK04_094257 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCOCC4 5202440.0 225000.0 0.25 4785640.0 -594000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N02 compound treatment 5584000.0 191989.375 0.212284638369457 0.3284 0.9926 3186910 PK04_094258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 5159040.0 181000.0 0.2 5536800.0 157000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N03 compound treatment 5295080.0 -96930.625 -0.107177194962224 0.6777 0.7179 3067987 PK04_094259 CN(C)C(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 5719400.0 742000.0 0.81 5846440.0 467000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N04 compound treatment 6189680.0 797669.375 0.881991281081392 1.1615 0.8733 3186911 PK04_094260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 5109960.0 132000.0 0.14 6360800.0 981000.0 0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N05 compound treatment 6393200.0 1001189.375 1.10702545081579 1.0567 0.8506 3414052 PK04_094261 COC(=O)[C@@H]1N=C(O[C@@H]1C)c2ccc(OCCCO)cc2 5460800.0 483000.0 0.53 5572840.0 193000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N06 compound treatment 6240400.0 848389.375 0.938072909859541 1.1514 0.9571 3186912 PK04_094262 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 5397120.0 420000.0 0.46 5974160.0 595000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N07 compound treatment 5728520.0 336509.375 0.372081897656092 0.5805 0.9709 3186913 PK04_094263 OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 5354480.0 377000.0 0.41 5599440.0 220000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N08 compound treatment 6184520.0 792509.375 0.876285815693079 1.1385 0.9732 1952953 PK04_094264 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 5466200.0 489000.0 0.54 5938080.0 559000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N09 mock treatment 5526240.0 134229.375 0.148418808751439 0.8936 0.5601 6418800.0 1440000.0 1.58 5201240.0 -178000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N10 mock treatment 5386760.0 -5250.625 -0.0058056703884714 0.15 0.4878 5256000.0 278000.0 0.3 5340360.0 -39200.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N11 compound treatment 5494040.0 102029.375 0.112814935591809 0.55 0.7985 3068027 PK04_094265 CC(=O)OC[C@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 5147720.0 170000.0 0.19 6030640.0 651000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N12 compound treatment 3864400.0 -1527610.625 -1.68909487359634 -2.6825 -0.9846 3186914 PK04_094266 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 3914640.0 -1060000.0 -1.16 3592880.0 -1790000.0 -1.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N13 mock treatment 6124720.0 732709.375 0.810164336968053 1.8047 0.8536 6722000.0 1740000.0 1.91 5783360.0 404000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N14 mock treatment 5886640.0 494629.375 0.54691681765611 1.3159 0.8678 5312120.0 335000.0 0.37 6740640.0 1360000.0 1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N15 compound treatment 5774920.0 382909.375 0.423386857737048 1.1015 0.8542 3068028 PK04_094267 CC(=O)OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 5256400.0 279000.0 0.31 6554520.0 1170000.0 1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N16 compound treatment 5112680.0 -279330.625 -0.308858762177018 -1.5936 -0.6382 3186915 PK04_094268 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 2714840.0 -2260000.0 -2.48 5406000.0 26500.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N17 compound treatment 5965400.0 573389.375 0.634002564552148 0.6542 0.843 3068029 PK04_094269 CC(=O)OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 5383200.0 406000.0 0.44 5434240.0 54700.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N18 compound treatment 4499360.0 -892650.625 -0.987013031936766 -2.2182 -0.9838 1952947 PK04_094270 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@@H](Cc5ccccc5)C/C=C/C[C@H](Cc6ccccc6)C(=O)O[C@@H]14 3793480.0 -1180000.0 -1.3 3826800.0 -1550000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N19 compound treatment 5559080.0 167069.375 0.184730336532874 -0.2122 -0.2864 3068030 PK04_094271 OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 4336800.0 -641000.0 -0.7 5528440.0 149000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N20 compound treatment 2698240.0 -2693770.625 -2.97853005135514 -4.7339 -0.9979 3186916 PK04_094272 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 2636000.0 -2340000.0 -2.56 2732520.0 -2650000.0 -2.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N21 compound treatment 5262520.0 -129490.625 -0.143179123846619 -0.0341 -0.1207 3068031 PK04_094273 CC(=O)OC[C@@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 5168160.0 191000.0 0.21 5255480.0 -124000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N22 compound treatment 2944680.0 -2447330.625 -2.70603879354585 -4.4855 -0.9981 1952944 PK04_094274 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 2817160.0 -2160000.0 -2.37 2692000.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N23 compound treatment 4488160.0 -903850.625 -0.999396987818376 -1.1971 -0.9488 3186917 PK04_094275 CC(=O)OC[C@H](C=C)N(Cc1ccc(cc1)[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 4569920.0 -408000.0 -0.45 4754160.0 -625000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 N24 compound treatment 5700320.0 308309.375 0.340900865882752 -0.794 -0.5319 3413982 PK04_094276 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 4710400.0 -267000.0 -0.29 3961080.0 -1420000.0 -1.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O01 compound treatment 1856960.0 -3535050.625 -3.90874205171952 -6.4501 -0.9993 3068032 PK04_094277 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1621360.0 -3360000.0 -3.68 1804640.0 -3570000.0 -3.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O02 compound treatment 2976280.0 -2415730.625 -2.67109834659417 -4.8977 -0.9992 3186919 PK04_094278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 2352000.0 -2630000.0 -2.88 2453400.0 -2930000.0 -2.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O03 compound treatment 5016240.0 -375770.625 -0.415493468000455 -0.8366 -0.867 3068033 PK04_094279 NC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 4811560.0 -166000.0 -0.18 4530880.0 -849000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O04 compound treatment 5652560.0 260549.375 0.288092139730457 0.2087 0.7038 3186920 PK04_094280 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 5041680.0 64100.0 0.07 5382720.0 3170.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O05 compound treatment 2317200.0 -3074810.625 -3.39984992181306 -5.5877 -0.999 3068035 PK04_094281 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 2201520.0 -2780000.0 -3.04 2152800.0 -3230000.0 -3.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O06 compound treatment 5183880.0 -208130.625 -0.230132185501068 -0.2334 -0.5057 3186921 PK04_094282 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 5143880.0 166000.0 0.18 5024560.0 -355000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O07 compound treatment 2731640.0 -2660370.625 -2.94159932577962 -4.9669 -0.9996 3186922 PK04_094283 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 2468120.0 -2510000.0 -2.75 2476680.0 -2900000.0 -2.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O08 compound treatment 5048760.0 -343250.625 -0.379535767529922 -0.5539 -0.9035 3068037 PK04_094284 CN(C)C(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 4875800.0 -102000.0 -0.11 4912840.0 -467000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O09 compound treatment 3491440.0 -1900570.625 -2.10148060445396 -3.7406 -0.9981 3186923 PK04_094285 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 3122560.0 -1860000.0 -2.03 3042000.0 -2340000.0 -2.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O10 compound treatment 2887800.0 -2504210.625 -2.76893159805889 -4.4322 -0.9732 3068038 PK04_094286 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 3393000.0 -1580000.0 -1.74 2218360.0 -3160000.0 -3.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O11 mock treatment 5743720.0 351709.375 0.388888694923991 0.7565 0.9774 5496880.0 519000.0 0.57 5731040.0 351000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O12 mock treatment 5360960.0 -31050.625 -0.0343329973300378 0.0897 0.3609 4930920.0 -46700.0 -0.05 5619480.0 240000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O13 compound treatment 5521280.0 129269.375 0.14293448543244 0.4923 0.858 3186924 PK04_094287 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 5147600.0 170000.0 0.19 5901200.0 522000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O14 compound treatment 4631800.0 -760210.625 -0.840572753636726 -1.5422 -0.9861 3186925 PK04_094288 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 3978600.0 -999000.0 -1.09 4645520.0 -734000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O15 compound treatment 5570920.0 178909.375 0.197821947036291 0.8899 0.9155 3187013 PK04_094289 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 5627960.0 650000.0 0.71 6008520.0 629000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O16 compound treatment 4003080.0 -1388930.625 -1.53575496273369 -2.8777 -0.9984 3068077 PK04_094290 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 3433360.0 -1540000.0 -1.69 3628280.0 -1750000.0 -1.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O17 compound treatment 4494400.0 -897610.625 -0.992497355255765 -1.6641 -0.9986 3187014 PK04_094291 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 4166320.0 -811000.0 -0.89 4381800.0 -998000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O18 compound treatment 2673480.0 -2718530.625 -3.00590743953627 -4.035 -0.9759 3187015 PK04_094292 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 3391560.0 -1590000.0 -1.74 3141440.0 -2240000.0 -2.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O19 compound treatment 5467240.0 75229.375 0.0831818983036706 -0.1564 -0.194 3068081 PK04_094293 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 5307840.0 330000.0 0.36 4666400.0 -713000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O20 compound treatment 2892640.0 -2499370.625 -2.76357995998148 -3.4162 -0.9087 3187016 PK04_094294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCCCC4 4334600.0 -643000.0 -0.7 2938920.0 -2440000.0 -2.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O21 compound treatment 4370160.0 -1021850.625 -1.12987080871391 -1.3487 -0.9449 3187017 PK04_094295 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 4544680.0 -433000.0 -0.47 4650040.0 -730000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O22 compound treatment 3202400.0 -2189610.625 -2.42107512302723 -3.214 -0.9675 3068083 PK04_094296 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 3848280.0 -1130000.0 -1.24 3477320.0 -1900000.0 -1.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O23 compound treatment 2444920.0 -2947090.625 -3.25862859634885 -4.7957 -0.9897 3187018 PK04_094297 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 2895760.0 -2080000.0 -2.28 2621480.0 -2760000.0 -2.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 O24 compound treatment 1947840.0 -3444170.625 -3.80825509542302 -5.3122 -0.9857 3068084 PK04_094298 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCc4ccccc4 2522280.0 -2460000.0 -2.69 2685240.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P01 compound treatment 2979440.0 -2412570.625 -2.667604301899 -4.4086 -0.9992 3187019 PK04_094299 CC(=O)OC[C@H](C=C)N(Cc1ccccc1[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 2766960.0 -2210000.0 -2.42 2841160.0 -2540000.0 -2.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P02 compound treatment 4146960.0 -1245050.625 -1.37666535806886 -2.3259 -0.9806 3413984 PK04_094300 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 4065600.0 -912000.0 -1.0 3732280.0 -1650000.0 -1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P03 compound treatment 4553200.0 -838810.625 -0.927481586877312 -1.2547 -0.9005 3068086 PK04_094301 COc1ccc(CN([C@H](CO)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 4765680.0 -212000.0 -0.23 4369520.0 -1010000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P04 compound treatment 4660720.0 -731290.625 -0.808595610413853 -1.4428 -0.9429 3413986 PK04_094302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 4534280.0 -443000.0 -0.49 4178960.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P05 compound treatment 5138360.0 -253650.625 -0.280464120477041 -0.526 -0.7067 3068087 PK04_094303 COc1cc(CN([C@@H](COC(=O)C)C=C)S(=O)(=O)c2ccc(Br)cc2)ccc1OC(=O)C 5029200.0 51600.0 0.06 4694840.0 -685000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P06 compound treatment 3586920.0 -1805090.625 -1.99590738056323 -3.2658 -0.9729 1952975 PK04_094304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 3799600.0 -1180000.0 -1.29 3017480.0 -2360000.0 -2.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P07 compound treatment 5026000.0 -366010.625 -0.404701735017909 -0.6637 -0.9954 3068088 PK04_094305 OCCCNS(=O)(=O)c1ccc(Br)cc1 4675000.0 -303000.0 -0.33 4967480.0 -412000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P08 compound treatment 3559800.0 -1832210.625 -2.02589424516227 -3.6866 -0.999 3413993 PK04_094306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 3059960.0 -1920000.0 -2.1 3128160.0 -2250000.0 -2.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P09 compound treatment 5108320.0 -283690.625 -0.313679659288074 -0.4868 -0.503 3068089 PK04_094307 CC[Si](CC)(CC)OC[C@@H](C=C)N(Cc1ccc(OC(=O)C)c(OC)c1)S(=O)(=O)c2ccc(Br)cc2 5275240.0 298000.0 0.33 4527120.0 -852000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P10 compound treatment 2695960.0 -2696050.625 -2.98105107094533 -4.7566 -0.9926 1952969 PK04_094308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5ccccc5)C/C=C/C[C@@H](Cc6ccccc6)C(=O)O[C@@H]14 2902840.0 -2070000.0 -2.27 2404600.0 -2970000.0 -2.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P11 mock treatment 5053040.0 -338970.625 -0.374803327246593 -0.0757 -0.1353 5332760.0 355000.0 0.39 5234800.0 -145000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P12 mock treatment 5057040.0 -334970.625 -0.370380485860303 -1.6834 -0.7273 4724040.0 -254000.0 -0.28 3119880.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P13 compound treatment 4036400.0 -1355610.625 -1.4989126939859 -2.6222 -0.9648 3068090 PK04_094309 COc1cc(CO)ccc1OC(=O)C 4050000.0 -928000.0 -1.02 3359760.0 -2020000.0 -2.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P14 compound treatment 5252600.0 -139410.625 -0.154147770484617 -0.1569 -0.4319 3068091 PK04_094310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 5129400.0 152000.0 0.17 5096640.0 -283000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P15 compound treatment 4090320.0 -1301690.625 -1.43929279209872 -1.2821 -0.7507 3187025 PK04_094311 COc1ccc(CN(C2=CC[C@@]3(C(=O)N)C(=O)C(=C(Cl)C(=O)[C@]3(C2)C#N)Cl)S(=O)(=O)c4ccc(Br)cc4)cc1 5095240.0 118000.0 0.13 4472600.0 -907000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P16 compound treatment 5415880.0 23869.375 0.0263926149037152 -0.3464 -0.3983 3187026 PK04_094312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 5174560.0 197000.0 0.22 4540480.0 -839000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P17 compound treatment 5097000.0 -295010.625 -0.326196300411273 -0.6089 -0.9752 3068092 PK04_094313 CC(C)(C)OC(=O)N1[C@H](COC1(C)C)C=C(Br)Br 4731920.0 -246000.0 -0.27 4921720.0 -458000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P18 compound treatment 4775160.0 -616850.625 -0.682058118352115 -1.061 -0.9955 3187027 PK04_094314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 4415360.0 -562000.0 -0.62 4841440.0 -538000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P19 compound treatment 5072120.0 -319890.625 -0.353706373833993 -0.6707 -0.985 1003211 PK04_094315 CNS(=O)(=O)c1ccc(C)cc1 4679880.0 -298000.0 -0.33 4899320.0 -480000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P20 compound treatment 3948920.0 -1443090.625 -1.59564023510405 -2.0423 -0.9334 3187028 PK04_094316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 4476240.0 -501000.0 -0.55 3991760.0 -1390000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P21 compound treatment 4715240.0 -676770.625 -0.748312282318729 -0.9615 -0.847 3068127 PK04_094317 COc1cc(COC(=O)C)ccc1OC(=O)C 4917240.0 -60300.0 -0.07 4531560.0 -848000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P22 compound treatment 3853040.0 -1538970.625 -1.7016557431334 -1.9788 -0.8929 3187029 PK04_094318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 4658360.0 -319000.0 -0.35 4008240.0 -1370000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P23 compound treatment 5204920.0 -187090.625 -0.206868039809186 -1.2835 -0.8534 3068129 PK04_094319 OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 4336040.0 -642000.0 -0.7 4070560.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2094 P24 compound treatment 4215160.0 -1176850.625 -1.30125591243263 -2.5816 -0.99 3413981 PK04_094320 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 3714680.0 -1260000.0 -1.38 3598720.0 -1780000.0 -1.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A01 compound treatment 3409200.0 -1996975.48387097 -2.20807645436744 -3.6187 -0.9981 3067957 PK04_095001 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-] 3489040.0 -1960000.0 -2.15 3717240.0 -1900000.0 -1.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A02 compound treatment 3862440.0 -1543735.48387097 -1.70692429688699 -2.6349 -0.996 3187176 PK04_095002 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 4109120.0 -1340000.0 -1.47 4239200.0 -1380000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A03 compound treatment 2378440.0 -3027735.48387097 -3.34779845120034 -5.9176 -0.9988 3067577 PK04_095003 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 2119120.0 -3330000.0 -3.65 2380160.0 -3240000.0 -3.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A04 compound treatment 4339600.0 -1066575.48387097 -1.17932354791653 -2.3849 -0.9945 3187436 PK04_095004 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 4065200.0 -1390000.0 -1.52 4192840.0 -1430000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A05 compound treatment 2524120.0 -2882055.48387097 -3.18671856791168 -5.7724 -0.9995 3186425 PK04_095005 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6I)c7ccc(cc7)[N+](=O)[O-])cc1 2302560.0 -3150000.0 -3.45 2270120.0 -3350000.0 -3.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A06 compound treatment 4467080.0 -939095.48387097 -1.03836759293549 -1.9996 -0.9973 3187069 PK04_095006 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5 4371800.0 -1080000.0 -1.18 4382760.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A07 compound treatment 3837360.0 -1568815.48387097 -1.73465551237902 -2.5289 -0.9913 3187427 PK04_095007 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 4242560.0 -1210000.0 -1.33 4304200.0 -1310000.0 -1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A08 compound treatment 1923480.0 -3482695.48387097 -3.8508524304769 -6.5462 -0.9998 3187515 PK04_095008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6)c7ccc(cc7)[N+](=O)[O-])cc1 1988280.0 -3470000.0 -3.79 1939400.0 -3680000.0 -3.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A09 compound treatment 3970480.0 -1435695.48387097 -1.58746335104331 -2.2923 -0.9892 3187425 PK04_095009 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 4297560.0 -1160000.0 -1.27 4505840.0 -1110000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A10 compound treatment 4423040.0 -983135.48387097 -1.08706307659854 -1.8678 -0.983 3068592 PK04_095010 CCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 4247880.0 -1210000.0 -1.32 4794040.0 -825000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A11 compound treatment 1986920.0 -3419255.48387097 -3.78070616609035 -6.4111 -0.9999 3187517 PK04_095011 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-] 2095040.0 -3360000.0 -3.68 1986080.0 -3630000.0 -3.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A12 compound treatment 4072000.0 -1334175.48387097 -1.47521163665929 -2.3116 -0.9972 3187344 PK04_095012 COCCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 4280840.0 -1170000.0 -1.28 4378840.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A13 mock treatment 4594240.0 -811935.48387097 -0.897765465265351 -1.3742 -0.9918 4855520.0 -598000.0 -0.65 4794240.0 -825000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A14 mock treatment 4216800.0 -1189375.48387097 -1.31510477847562 -1.9206 -0.9854 4673640.0 -780000.0 -0.85 4465480.0 -1150000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A15 compound treatment 3577680.0 -1828495.48387097 -2.02178637517693 -3.1639 -0.9917 3186552 PK04_095013 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 4090680.0 -1360000.0 -1.49 3660120.0 -1960000.0 -1.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A16 compound treatment 4296800.0 -1109375.48387097 -1.22664795074983 -1.6457 -0.9676 3187439 PK04_095014 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 4882840.0 -571000.0 -0.63 4623600.0 -995000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A17 compound treatment 4112160.0 -1294015.48387097 -1.43080630914095 -2.1637 -0.9939 3187073 PK04_095015 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 4454560.0 -999000.0 -1.09 4400360.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A18 compound treatment 4484080.0 -922095.48387097 -1.01957051704376 -1.82 -0.9991 3187272 PK04_095016 COCCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 4523280.0 -930000.0 -1.02 4508800.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A19 compound treatment 4329480.0 -1076695.48387097 -1.19051333662384 -1.8187 -0.9948 3187508 PK04_095017 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NC3CC3)c4ccc(cc4)[N+](=O)[O-] 4511560.0 -942000.0 -1.03 4694080.0 -925000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A20 compound treatment 2598600.0 -2807575.48387097 -3.10436526129898 -5.4525 -0.9958 3186432 PK04_095018 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 2237680.0 -3220000.0 -3.52 2810920.0 -2810000.0 -2.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A21 compound treatment 3421880.0 -1984295.48387097 -2.1940560471729 -3.8402 -0.9981 3068646 PK04_095019 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 3268400.0 -2190000.0 -2.39 3561800.0 -2060000.0 -2.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A22 compound treatment 4000880.0 -1405295.48387097 -1.55384975650752 -2.2611 -0.9834 3068651 PK04_095020 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 4559200.0 -894000.0 -0.98 4240600.0 -1380000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A23 compound treatment 3989040.0 -1417135.48387097 -1.56694136701093 -2.9266 -0.9928 3187585 PK04_095021 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 4061440.0 -1390000.0 -1.52 3648360.0 -1970000.0 -1.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 A24 compound treatment 3526120.0 -1880055.48387097 -2.0787968006462 -3.3787 -0.9989 3187430 PK04_095022 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 3742120.0 -1710000.0 -1.87 3726560.0 -1890000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B01 compound treatment 1800200.0 -3605975.48387097 -3.98716440200233 -6.8673 -0.9998 3187519 PK04_095023 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-])c(I)c1 1760480.0 -3690000.0 -4.04 1769560.0 -3850000.0 -3.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B02 compound treatment 4345800.0 -1060375.48387097 -1.17246814376778 -1.9749 -0.995 3186885 PK04_095024 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 4552240.0 -901000.0 -0.99 4362120.0 -1260000.0 -1.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B03 compound treatment 4662480.0 -743695.48387097 -0.822311791215255 -2.2398 -0.9408 3187435 PK04_095025 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 4422240.0 -1030000.0 -1.13 3697960.0 -1920000.0 -1.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B04 compound treatment 4106600.0 -1299575.48387097 -1.43695405866789 -2.5598 -0.9991 3186491 PK04_095026 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 4023320.0 -1430000.0 -1.57 4193480.0 -1430000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B05 compound treatment 5143680.0 -262495.48387097 -0.290243972444645 -1.2378 -0.9179 3068539 PK04_095027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(F)cc(c4)C(F)(F)F 4689720.0 -764000.0 -0.84 4605240.0 -1010000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B06 compound treatment 4839600.0 -566575.48387097 -0.626468374630362 -1.6994 -0.9526 3186559 PK04_095028 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 4606120.0 -847000.0 -0.93 4234800.0 -1380000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B07 compound treatment 4687320.0 -718855.48387097 -0.794845946206398 -1.6274 -0.9615 3068561 PK04_095029 CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 4252080.0 -1200000.0 -1.32 4913160.0 -706000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B08 compound treatment 3145520.0 -2260655.48387097 -2.49963015855163 -4.4686 -0.9997 3068322 PK04_095030 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 3044480.0 -2410000.0 -2.64 3026040.0 -2590000.0 -2.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B09 compound treatment 4345400.0 -1060775.48387097 -1.17291042790641 -1.405 -0.953 3187432 PK04_095031 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 4915960.0 -538000.0 -0.59 4949320.0 -669000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B10 compound treatment 4846960.0 -559215.48387097 -0.618330346479589 -1.111 -0.9131 3068145 PK04_095032 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(F)(F)F)c5ccccc5C2=O 4537520.0 -916000.0 -1.0 5317160.0 -302000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B11 compound treatment 4880440.0 -525735.48387097 -0.581311164076347 -0.9947 -0.8983 3187265 PK04_095033 CC(C)N1[C@H]([C@H](C(=O)NCCCN(C)C)c2ccccc2C1=O)c3ccc(CO)cc3 4618280.0 -835000.0 -0.91 5392800.0 -226000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B12 compound treatment 4985400.0 -420775.48387097 -0.465255806100115 -1.1816 -0.9748 3186629 PK04_095034 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 4699960.0 -754000.0 -0.83 4865480.0 -753000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B13 mock treatment 5312160.0 -94015.4838709701 -0.103953893254137 -0.8845 -0.7172 5253760.0 -200000.0 -0.22 4413840.0 -1200000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B14 mock treatment 5121400.0 -284775.48387097 -0.314879198966276 -0.8221 -0.8446 4635440.0 -818000.0 -0.9 5406480.0 -212000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B15 compound treatment 4620960.0 -785215.48387097 -0.868220884804938 -1.8079 -0.9724 3187269 PK04_095035 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3CCCCC3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 4663520.0 -790000.0 -0.87 4225880.0 -1390000.0 -1.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B16 compound treatment 5115200.0 -290975.48387097 -0.321734603115025 -0.9107 -0.9602 3186887 PK04_095036 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4823520.0 -630000.0 -0.69 5055160.0 -564000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B17 compound treatment 4867520.0 -538655.48387097 -0.595596941754062 -0.8541 -0.8749 3068417 PK04_095037 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 4755880.0 -698000.0 -0.76 5499600.0 -119000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B18 compound treatment 4892360.0 -513815.48387097 -0.568131096745205 -1.6327 -0.8039 3067610 PK04_095038 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(C7CC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 3700320.0 -1750000.0 -1.92 5280320.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B19 compound treatment 4354280.0 -1051895.48387097 -1.16309172002885 -1.7983 -0.9964 3068639 PK04_095039 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 4563920.0 -890000.0 -0.97 4644920.0 -974000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B20 compound treatment 4870720.0 -535455.48387097 -0.592058668645031 -0.676 -0.8344 3068006 PK04_095040 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 4949200.0 -504000.0 -0.55 5592400.0 -26400.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B21 compound treatment 4854160.0 -552015.48387097 -0.610369231984269 -0.9654 -0.9814 3068601 PK04_095041 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCc4ccccc4)c5ccccc5C2=O 4854360.0 -599000.0 -0.66 5214640.0 -404000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B22 compound treatment 4484840.0 -921335.48387097 -1.01873017718037 -1.7022 -0.9994 3068203 PK04_095042 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5Cl)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 4548880.0 -905000.0 -0.99 4683240.0 -936000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B23 compound treatment 4542640.0 -863535.48387097 -0.954820119148484 -1.7236 -0.998 3187355 PK04_095043 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCC(F)(F)F)c4ccccc4C2=O 4463240.0 -990000.0 -1.08 4676200.0 -943000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 B24 compound treatment 4186320.0 -1219855.48387097 -1.34880682983914 -2.5199 -0.9983 3068156 PK04_095044 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 4035000.0 -1420000.0 -1.55 4161680.0 -1460000.0 -1.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C01 compound treatment 4151800.0 -1254375.48387097 -1.38697595100282 -2.137 -0.9858 3187590 PK04_095045 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 4195360.0 -1260000.0 -1.38 4685600.0 -933000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C02 compound treatment 4667320.0 -738855.48387097 -0.816960153137845 -1.6328 -0.9946 3187180 PK04_095046 CC(C)NC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 4582400.0 -871000.0 -0.95 4565480.0 -1050000.0 -1.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C03 compound treatment 4524240.0 -881935.48387097 -0.975165189525415 -2.1744 -0.9865 3186493 PK04_095047 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 4106120.0 -1350000.0 -1.48 4308040.0 -1310000.0 -1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C04 compound treatment 1396000.0 -4010175.48387097 -4.43409252408687 -7.6988 -0.9829 3186427 PK04_095048 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 2320080.0 -3130000.0 -3.43 169280.0 -5450000.0 -5.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C05 compound treatment 4872160.0 -534015.48387097 -0.590466445745966 -0.914 -0.9905 3187172 PK04_095049 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 4935200.0 -518000.0 -0.57 5195320.0 -423000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C06 compound treatment 5279720.0 -126455.48387097 -0.139823136896943 -0.3878 -0.964 3187080 PK04_095050 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 5192200.0 -261000.0 -0.29 5373960.0 -245000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C07 compound treatment 5381720.0 -24455.4838709701 -0.0270406815465646 -0.6737 -0.835 3186988 PK04_095051 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 4948240.0 -505000.0 -0.55 5034480.0 -584000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C08 compound treatment 3151920.0 -2254255.48387097 -2.49255361233357 -4.5935 -0.9983 3068011 PK04_095052 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 3077280.0 -2380000.0 -2.6 2767640.0 -2850000.0 -2.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C09 compound treatment 4791760.0 -614415.48387097 -0.679365557610383 -0.9499 -0.9854 3068498 PK04_095053 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4989960.0 -464000.0 -0.51 5162160.0 -457000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C10 compound treatment 3529240.0 -1876935.48387097 -2.07534698436489 -3.6711 -0.9411 3186550 PK04_095054 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 2647200.0 -2810000.0 -3.07 4413280.0 -1210000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C11 mock treatment 5134920.0 -271255.48387097 -0.299929995080618 -0.6587 -0.8319 4793200.0 -660000.0 -0.72 5501480.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C12 mock treatment 4989560.0 -416615.48387097 -0.460656051058374 -0.5023 -0.8136 5455080.0 1480.0 0.0 5209320.0 -409000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C13 compound treatment 4788160.0 -618015.48387097 -0.683346114858043 -1.3889 -0.9926 3187361 PK04_095055 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 4609640.0 -844000.0 -0.92 4823600.0 -795000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C14 compound treatment 4934160.0 -472015.48387097 -0.521912404258481 -0.8604 -0.7773 3068504 PK04_095056 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 4562160.0 -891000.0 -0.98 5626560.0 7800.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C15 mock treatment 5508480.0 102304.51612903 0.113119161984945 -0.0717 -0.2117 5520640.0 67000.0 0.07 5309120.0 -310000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C16 mock treatment 4533640.0 -872535.48387097 -0.964771512267635 -1.1623 -0.9479 4876920.0 -577000.0 -0.63 5203440.0 -415000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C17 compound treatment 5622680.0 216504.51612903 0.239391283563507 -0.0735 -0.1419 3067969 PK04_095057 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCCN(C)C)c3ccc(cc3)[N+](=O)[O-] 5041560.0 -412000.0 -0.45 5703040.0 84300.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C18 compound treatment 5367760.0 -38415.4838709701 -0.0424763979847145 -0.5529 -0.8099 3187359 PK04_095058 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 4898000.0 -556000.0 -0.61 5313120.0 -306000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C19 compound treatment 4932440.0 -473735.48387097 -0.523814226054586 -0.5214 -0.7569 3187087 PK04_095059 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 5049280.0 -404000.0 -0.44 5682080.0 63300.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C20 compound treatment 4903480.0 -502695.48387097 -0.555835597691321 -0.6657 -0.8348 3187443 PK04_095060 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 4931920.0 -522000.0 -0.57 5592880.0 -25900.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C21 compound treatment 4854080.0 -552095.48387097 -0.610457688811994 -1.4732 -0.9742 3067571 PK04_095061 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 4678960.0 -775000.0 -0.85 4529760.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C22 compound treatment 4714520.0 -691655.48387097 -0.76477062477963 -1.3063 -0.997 3187181 PK04_095062 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 4704560.0 -749000.0 -0.82 4943640.0 -675000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C23 compound treatment 4474800.0 -931375.48387097 -1.02983150905995 -1.6515 -0.9983 3187509 PK04_095063 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)c4ccc(cc4)[N+](=O)[O-])cc1 4632520.0 -821000.0 -0.9 4690640.0 -928000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 C24 compound treatment 4011000.0 -1395175.48387097 -1.5426599678002 -2.5556 -0.9955 3068474 PK04_095064 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4285240.0 -1170000.0 -1.28 4020120.0 -1600000.0 -1.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D01 compound treatment 3547640.0 -1858535.48387097 -2.05500191398796 -3.5435 -0.9978 3068587 PK04_095065 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(CC3(CC4CC5CC(C4)C3)C5)C(=O)c6ccccc26)c7ccc(CO)cc7)cc1 3436200.0 -2020000.0 -2.21 3752280.0 -1870000.0 -1.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D02 compound treatment 2495440.0 -2910735.48387097 -3.21843034065138 -6.0994 -0.9957 3068318 PK04_095066 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1819960.0 -3630000.0 -3.98 2263960.0 -3350000.0 -3.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D03 compound treatment 4855760.0 -550415.48387097 -0.608600095429753 -1.2459 -0.9941 3187363 PK04_095067 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 4756280.0 -697000.0 -0.76 4835920.0 -783000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D04 compound treatment 4968520.0 -437655.48387097 -0.483920196750256 -0.9958 -0.9846 3186486 PK04_095068 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CCN7CCOCC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 4975760.0 -478000.0 -0.52 4903840.0 -715000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D05 compound treatment 4856480.0 -549695.48387097 -0.607803983980221 -0.9732 -0.8772 3187179 PK04_095069 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(=O)c3ccccc23)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 5303520.0 -150000.0 -0.16 4708480.0 -910000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D06 compound treatment 4426160.0 -980015.48387097 -1.08361326031723 -1.7809 -0.9929 3187522 PK04_095070 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)O)cc1 4671040.0 -783000.0 -0.86 4478840.0 -1140000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D07 compound treatment 5551040.0 144864.51612903 0.160178194335064 -0.7485 -0.5684 3068515 PK04_095071 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 5308200.0 -145000.0 -0.16 4326040.0 -1290000.0 -1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D08 compound treatment 5443760.0 37584.5161290299 0.0415575883547834 -0.1549 -0.2403 3186872 PK04_095072 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 4921520.0 -532000.0 -0.58 5890600.0 272000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D09 compound treatment 4904320.0 -501855.48387097 -0.5549068010002 -0.8124 -0.8909 3068609 PK04_095073 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 5323240.0 -130000.0 -0.14 4911840.0 -707000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D10 compound treatment 2794480.0 -2611695.48387097 -2.88777871861239 -5.0901 -0.9986 3186795 PK04_095074 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2575520.0 -2880000.0 -3.15 2852000.0 -2770000.0 -2.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D11 mock treatment 6042760.0 636584.51612903 0.703878085951615 0.2574 0.334 5170680.0 -283000.0 -0.31 5670440.0 51700.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D12 mock treatment 5737800.0 331624.51612903 0.366680658660914 -0.3862 -0.4623 4874440.0 -579000.0 -0.63 5218840.0 -400000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D13 compound treatment 5184720.0 -221455.48387097 -0.244865619821316 -0.5865 -0.9465 3067964 PK04_095075 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 4995960.0 -458000.0 -0.5 5349920.0 -269000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D14 compound treatment 5394280.0 -11895.4838709701 -0.013152959593616 -0.0732 -0.67 3068230 PK04_095076 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 5354680.0 -98900.0 -0.11 5613480.0 -5280.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D15 mock treatment 5166680.0 -239495.48387097 -0.264812634473481 -0.2958 -0.4407 4958840.0 -495000.0 -0.54 5912080.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D16 mock treatment 4986160.0 -420015.48387097 -0.46441546623672 -0.1597 -0.3234 5605000.0 151000.0 0.17 5640760.0 22000.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D17 compound treatment 4942440.0 -463735.48387097 -0.512757122588862 0.0509 0.075 3068595 PK04_095077 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCc3ccccc3)c4ccccc4C1=O 5642360.0 189000.0 0.21 6011640.0 393000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D18 compound treatment 5624880.0 218704.51612903 0.241823846325966 -0.2279 -0.327 3186982 PK04_095078 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4857080.0 -597000.0 -0.65 5635480.0 16700.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D19 compound treatment 5028000.0 -378175.48387097 -0.418152545336133 -1.1747 -0.9282 3187440 PK04_095079 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 4491720.0 -962000.0 -1.05 5057720.0 -561000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D20 compound treatment 5309760.0 -96415.4838709701 -0.10660759808591 -0.9182 -0.8654 3068415 PK04_095080 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4851280.0 -602000.0 -0.66 4797480.0 -821000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D21 compound treatment 4879560.0 -526615.48387097 -0.582284189181331 -0.8463 -0.9749 3068596 PK04_095081 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCC(F)(F)F)c3ccccc3C1=O 4949720.0 -504000.0 -0.55 5288240.0 -331000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D22 compound treatment 3119200.0 -2286975.48387097 -2.52873245487342 -3.9975 -0.9781 3186713 PK04_095082 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 2926440.0 -2530000.0 -2.77 3996880.0 -1620000.0 -1.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D23 compound treatment 4524080.0 -882095.48387097 -0.975342103180867 -0.9224 -0.8417 3187357 PK04_095083 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 5016600.0 -437000.0 -0.48 5475600.0 -143000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 D24 compound treatment 1797080.0 -3609095.48387097 -3.99061421828364 -6.6125 -0.9992 3068270 PK04_095084 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCCN6CCOCC6)cc1 1937000.0 -3520000.0 -3.85 2020120.0 -3600000.0 -3.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E01 mock treatment 4534440.0 -871735.48387097 -0.963886943990377 -1.7371 -0.9982 4579240.0 -874000.0 -0.96 4535360.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E02 mock treatment 5063640.0 -342535.48387097 -0.378745028584295 -0.8687 -0.9758 4859840.0 -594000.0 -0.65 5144880.0 -474000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E03 compound treatment 4903000.0 -503175.48387097 -0.556366338657675 -1.1116 -0.9651 3068636 PK04_095085 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 5011240.0 -442000.0 -0.48 4737440.0 -881000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E04 compound treatment 4478240.0 -927935.48387097 -1.02602786546774 -0.896 -0.7585 3186556 PK04_095086 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 5505400.0 51800.0 0.06 5038200.0 -581000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E05 compound treatment 5110480.0 -295695.48387097 -0.326953555950846 -0.2476 -0.7183 3187587 PK04_095087 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 5354000.0 -99600.0 -0.11 5625880.0 7120.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E06 compound treatment 2155200.0 -3250975.48387097 -3.59463722896915 -6.0382 -0.9989 3186428 PK04_095088 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 2483480.0 -2970000.0 -3.25 2020440.0 -3600000.0 -3.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E07 compound treatment 5249640.0 -156535.48387097 -0.173082904121839 -0.0317 -0.1048 3187266 PK04_095089 CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 5658560.0 205000.0 0.22 5512800.0 -106000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E08 compound treatment 5768800.0 362624.51612903 0.400957679404657 0.255 0.5705 3187351 PK04_095090 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 5598280.0 145000.0 0.16 5501400.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E09 mock treatment 5372160.0 -34015.4838709701 -0.0376112724597962 0.36 0.7631 5722640.0 269000.0 0.29 5983960.0 365000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E10 mock treatment 5495760.0 89584.5161290299 0.0990545263765451 -0.0693 -0.0779 5915600.0 462000.0 0.51 4896320.0 -722000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E11 compound treatment 5359360.0 -46815.4838709701 -0.0517643648959221 -0.7176 -0.4996 3068004 PK04_095091 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 5660200.0 207000.0 0.23 4206360.0 -1410000.0 -1.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E12 compound treatment 4854400.0 -551775.48387097 -0.610103861501091 -1.1505 -0.9308 3186500 PK04_095092 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 4533800.0 -920000.0 -1.01 5244800.0 -374000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E13 compound treatment 6730680.0 1324504.51612903 1.46451834756566 1.4032 0.8183 3187346 PK04_095093 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCN3CCOCC3)c4ccccc4C1=O 5524240.0 70600.0 0.08 6504160.0 885000.0 0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E14 compound treatment 5321760.0 -84415.4838709701 -0.0933390739270421 0.1765 0.3084 3187262 PK04_095094 CC(C)N1[C@H]([C@H](C(=O)NCCN2CCOCC2)c3ccccc3C1=O)c4ccc(CO)cc4 5951520.0 498000.0 0.55 5473000.0 -146000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E15 compound treatment 2995480.0 -2410695.48387097 -2.66553093895135 -5.0851 -0.9884 3067574 PK04_095095 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 2191520.0 -3260000.0 -3.57 3058160.0 -2560000.0 -2.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E16 compound treatment 5246720.0 -159455.48387097 -0.176311578333831 -0.0108 -0.03 3187350 PK04_095096 COCCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 5335320.0 -118000.0 -0.13 5904800.0 286000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E17 mock treatment 5793400.0 387224.51612903 0.428158153930337 0.3689 0.6725 5350440.0 -103000.0 -0.11 5941440.0 323000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E18 mock treatment 5186480.0 -219695.48387097 -0.242919569611348 0.2292 0.4144 5613280.0 160000.0 0.17 6082160.0 463000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E19 compound treatment 5334720.0 -71455.4838709701 -0.0790090678354646 -0.2663 -0.6682 3068657 PK04_095097 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 5461160.0 7560.0 0.01 5229720.0 -389000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E20 compound treatment 4480760.0 -925415.48387097 -1.02324147539438 -1.3492 -0.965 3068140 PK04_095098 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 4990400.0 -463000.0 -0.51 4815200.0 -804000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E21 compound treatment 4794680.0 -611495.48387097 -0.676136883398391 -0.9248 -0.9814 3186562 PK04_095099 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 4999920.0 -454000.0 -0.5 5191440.0 -427000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E22 compound treatment 4884000.0 -522175.48387097 -0.57737483524255 -1.0238 -0.9494 3187591 PK04_095100 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 5125880.0 -328000.0 -0.36 4784720.0 -834000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E23 compound treatment 5561760.0 155584.51612903 0.17203140925032 -0.3516 -0.5701 3187263 PK04_095101 CC(C)N1[C@H]([C@H](C(=O)NCc2ccccc2)c3ccccc3C1=O)c4ccc(CO)cc4 5235040.0 -219000.0 -0.24 5079080.0 -540000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 E24 compound treatment 4808960.0 -597215.48387097 -0.660347339649338 -1.1258 -0.9431 3068517 PK04_095102 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 4608560.0 -845000.0 -0.93 5255880.0 -363000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F01 mock treatment 4959280.0 -446895.48387097 -0.494136960352584 -1.118 -0.9508 4592640.0 -861000.0 -0.94 5121080.0 -498000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F02 mock treatment 4459520.0 -946655.48387097 -1.04672676315558 -1.1607 -0.8933 4782320.0 -671000.0 -0.74 5391000.0 -228000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F03 compound treatment 4729440.0 -676735.48387097 -0.748273426408771 -1.0233 -0.9786 3187079 PK04_095103 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 4924680.0 -529000.0 -0.58 5175480.0 -443000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F04 compound treatment 4707640.0 -698535.48387097 -0.772377911964048 -0.8158 -0.9022 3068331 PK04_095104 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 5080080.0 -374000.0 -0.41 5388080.0 -231000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F05 compound treatment 5126640.0 -279535.48387097 -0.309085276750237 -0.4358 -0.8086 3068563 PK04_095105 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 5449720.0 -3880.0 0.0 5178840.0 -440000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F06 compound treatment 5333160.0 -73015.4838709701 -0.0807339759761175 -0.2659 -0.8925 3186879 PK04_095106 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCCN6CCOCC6)cc1 5215240.0 -238000.0 -0.26 5500360.0 -118000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F07 compound treatment 2669360.0 -2736815.48387097 -3.02612519717552 -5.0644 -0.9991 3187523 PK04_095107 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)O)cc1 2945960.0 -2510000.0 -2.75 2630000.0 -2990000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F08 compound treatment 5962640.0 556464.51612903 0.615288572984239 0.296 0.4639 3186563 PK04_095108 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 5308200.0 -145000.0 -0.16 5675240.0 56500.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F09 mock treatment 5116320.0 -289855.48387097 -0.320496207526864 -0.1923 -0.564 5373160.0 -80400.0 -0.09 5694080.0 75300.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F10 mock treatment 5581560.0 175384.51612903 0.193924474112452 0.3057 0.9968 5614560.0 161000.0 0.18 5777560.0 159000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F11 compound treatment 5440680.0 34504.5161290299 0.0381520004873406 0.3076 0.5438 3187257 PK04_095109 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 5393480.0 -60100.0 -0.07 6177240.0 558000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F12 compound treatment 2961200.0 -2444975.48387097 -2.70343468963185 -4.7691 -0.993 3068241 PK04_095110 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 2552480.0 -2900000.0 -3.18 3247400.0 -2370000.0 -2.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F13 compound treatment 5377160.0 -29015.4838709701 -0.0320827207269345 0.335 0.7366 3068554 PK04_095111 COCCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 5820680.0 367000.0 0.4 5828360.0 210000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F14 compound treatment 5551320.0 145144.51612903 0.160487793232104 0.7412 0.8842 3068362 PK04_095112 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)Sc4ccc(C)cc4)cc1 5827840.0 374000.0 0.41 6329720.0 711000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F15 compound treatment 3746000.0 -1660175.48387097 -1.83567320964187 -3.0203 -0.9948 3186423 PK04_095113 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 3716880.0 -1740000.0 -1.9 4130400.0 -1490000.0 -1.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F16 compound treatment 5071480.0 -334695.48387097 -0.370076259467168 -1.0132 -0.5805 3068012 PK04_095114 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-] 3919520.0 -1530000.0 -1.68 5912800.0 294000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F17 mock treatment 5824920.0 418744.51612903 0.463010144054297 0.8488 0.8629 5593160.0 140000.0 0.15 6469960.0 851000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F18 mock treatment 5472760.0 66584.5161290299 0.0736231884053813 0.2922 0.9065 5605560.0 152000.0 0.17 5883800.0 265000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F19 compound treatment 4057360.0 -1348815.48387097 -1.49139923613311 -3.139 -0.9741 3067568 PK04_095115 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 3256120.0 -2200000.0 -2.41 4085200.0 -1530000.0 -1.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F20 compound treatment 2816160.0 -2590015.48387097 -2.8638069182987 -5.2723 -0.9967 3068266 PK04_095116 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 2356000.0 -3100000.0 -3.39 2753240.0 -2870000.0 -2.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F21 compound treatment 4014160.0 -1392015.48387097 -1.53916592310503 -2.2772 -0.9844 3186419 PK04_095117 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 4161880.0 -1290000.0 -1.41 4631800.0 -987000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F22 compound treatment 2411760.0 -2994415.48387097 -3.31095618245255 -5.7288 -0.9955 3187524 PK04_095118 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 2084320.0 -3370000.0 -3.69 2707320.0 -2910000.0 -2.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F23 compound treatment 5045840.0 -360335.48387097 -0.398426672753282 -0.6208 -0.8731 3068017 PK04_095119 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)O)c4ccccc4C2=O 5366200.0 -87400.0 -0.1 5039680.0 -579000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 F24 compound treatment 4605920.0 -800255.48387097 -0.884850768417386 -1.2186 -0.8529 3186554 PK04_095120 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 4434040.0 -1020000.0 -1.12 5509880.0 -109000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G01 compound treatment 3679280.0 -1726895.48387097 -1.90944620396518 -3.1037 -0.9986 3186418 PK04_095121 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 3819880.0 -1630000.0 -1.79 3947520.0 -1670000.0 -1.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G02 compound treatment 4862720.0 -543455.48387097 -0.600904351417609 -0.8776 -0.9288 3067966 PK04_095122 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCN3CCOCC3)c4ccc(cc4)[N+](=O)[O-] 4820600.0 -633000.0 -0.69 5393720.0 -225000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G03 mock treatment 4763720.0 -642455.48387097 -0.710369675728271 -0.3974 -0.5562 5415880.0 -37700.0 -0.04 5681960.0 63200.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G04 mock treatment 5239520.0 -166655.48387097 -0.184272692829151 0.051 0.1082 5828560.0 375000.0 0.41 5481160.0 -138000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G05 compound treatment 5680480.0 274304.51612903 0.303301341595388 -0.3457 -0.4534 3068153 PK04_095123 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 5227160.0 -226000.0 -0.25 4966960.0 -652000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G06 compound treatment 5272000.0 -134175.48387097 -0.148359220772482 0.0298 0.0593 3187356 PK04_095124 COCCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 5248880.0 -205000.0 -0.22 6041400.0 423000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G07 compound treatment 5382760.0 -23415.4838709701 -0.0258907427861294 0.0394 0.0516 3187173 PK04_095125 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 5987440.0 534000.0 0.58 5130080.0 -489000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G08 compound treatment 5972520.0 566344.51612903 0.626212991208374 0.7771 0.834 3068514 PK04_095126 CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 5481360.0 27800.0 0.03 6305720.0 687000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G09 compound treatment 5073920.0 -332255.48387097 -0.367378326221531 -0.416 -0.868 3187442 PK04_095127 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-] 5176160.0 -277000.0 -0.3 5569600.0 -49200.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G10 compound treatment 5885800.0 479624.51612903 0.530325789953621 0.859 0.9984 3068420 PK04_095128 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 5907120.0 454000.0 0.5 6078000.0 459000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G11 compound treatment 6188960.0 782784.51612903 0.865532938620492 0.4136 0.4713 3187434 PK04_095129 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 5320560.0 -133000.0 -0.15 5615360.0 -3400.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G12 compound treatment 4123800.0 -1282375.48387097 -1.41793584070684 -2.7484 -0.9895 3186416 PK04_095130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 3704800.0 -1750000.0 -1.92 4196600.0 -1420000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G13 compound treatment 5546800.0 140624.51612903 0.155489982465597 0.6173 0.872 3068507 PK04_095131 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 5713280.0 260000.0 0.28 6245880.0 627000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G14 compound treatment 5886040.0 479864.51612903 0.530591160436798 0.7806 0.9919 3187162 PK04_095132 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 5841120.0 388000.0 0.42 6014400.0 396000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G15 compound treatment 5881920.0 475744.51612903 0.52603563380892 0.7376 0.873 3068602 PK04_095133 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 5542680.0 89100.0 0.1 6270360.0 652000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G16 compound treatment 5587000.0 180824.51612903 0.199939538397805 0.2427 0.782 3187426 PK04_095134 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 5669880.0 216000.0 0.24 5602440.0 -16300.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G17 compound treatment 5200280.0 -205895.48387097 -0.22766076682865 -0.0632 -0.091 3067567 PK04_095135 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 5087920.0 -366000.0 -0.4 6135640.0 517000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G18 compound treatment 2569320.0 -2836855.48387097 -3.13674046024662 -5.1217 -0.9945 3187525 PK04_095136 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 2516600.0 -2940000.0 -3.22 3109880.0 -2510000.0 -2.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G19 mock treatment 5524080.0 117904.51612903 0.130368243391474 0.3546 0.7541 5483960.0 30400.0 0.03 6067760.0 449000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G20 mock treatment 6156400.0 750224.51612903 0.829531009736096 0.8597 0.9022 5787080.0 333000.0 0.37 5912040.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G21 compound treatment 5626240.0 220064.51612903 0.243327612397304 0.3433 0.9824 3187167 PK04_095137 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 5591680.0 138000.0 0.15 5818040.0 199000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G22 compound treatment 5440040.0 33864.5161290299 0.0374443458655343 0.0427 0.4382 3187174 PK04_095138 COc1ccccc1CN2[C@H]([C@H](C(=O)NC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 5414640.0 -39000.0 -0.04 5697640.0 78900.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G23 compound treatment 5171000.0 -235175.48387097 -0.260035965776288 -0.2877 -0.7307 3068478 PK04_095139 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 5188000.0 -266000.0 -0.29 5671200.0 52400.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 G24 compound treatment 4814080.0 -592095.48387097 -0.654686102674888 -1.2066 -0.9946 3068471 PK04_095140 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5Cl 4872120.0 -581000.0 -0.64 4823120.0 -796000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H01 compound treatment 3833640.0 -1572535.48387097 -1.73876875486827 -2.7416 -0.9952 3068149 PK04_095141 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 3955920.0 -1500000.0 -1.64 4253960.0 -1360000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H02 compound treatment 3630120.0 -1776055.48387097 -1.96380292460268 -3.83 -0.9947 3068236 PK04_095142 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 3155960.0 -2300000.0 -2.52 3472600.0 -2150000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H03 mock treatment 5559360.0 153184.51612903 0.169377704418546 0.3272 0.8626 5758000.0 304000.0 0.33 5682560.0 63800.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H04 mock treatment 5614160.0 207984.51612903 0.22997063141071 -0.175 -0.2566 5545720.0 92100.0 0.1 4987120.0 -632000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H05 compound treatment 5787040.0 380864.51612903 0.421125836126136 0.5568 0.9117 3187083 PK04_095143 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 5560080.0 106000.0 0.12 6043880.0 425000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H06 compound treatment 4161320.0 -1244855.48387097 -1.37644958850345 -2.8968 -0.9812 3068265 PK04_095144 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 4074400.0 -1380000.0 -1.51 3495760.0 -2120000.0 -2.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H07 compound treatment 4592320.0 -813855.48387097 -0.89988842913077 -0.3592 -0.3462 3068458 PK04_095145 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 5889000.0 435000.0 0.48 5420400.0 -198000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H08 compound treatment 5687320.0 281144.51612903 0.310864400365943 0.9663 0.9543 3068401 PK04_095146 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 6082840.0 629000.0 0.69 6290160.0 671000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H09 compound treatment 5706960.0 300784.51612903 0.332580551572623 1.0408 0.9488 3187071 PK04_095147 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 6195640.0 742000.0 0.81 6273960.0 655000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H10 compound treatment 5013680.0 -392495.48387097 -0.433986317499049 -1.2357 -0.9272 3068139 PK04_095148 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 4909120.0 -544000.0 -0.6 4512720.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H11 compound treatment 5793240.0 387064.51612903 0.427981240274885 0.6692 0.9762 3187589 PK04_095149 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 5697240.0 244000.0 0.27 6081320.0 463000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H12 compound treatment 5940320.0 534144.51612903 0.590609118048745 0.9142 0.9662 3186627 PK04_095150 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6 6056320.0 603000.0 0.66 5950280.0 332000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H13 compound treatment 5718040.0 311864.51612903 0.344831822212645 0.8044 0.9644 3187261 PK04_095151 CC(C)N1[C@H]([C@H](C(=O)NC2CC2)c3ccccc3C1=O)c4ccc(CO)cc4 6038760.0 585000.0 0.64 6024920.0 406000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H14 compound treatment 6792440.0 1386264.51612903 1.53280701856997 1.5961 0.9037 3186980 PK04_095152 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 6085000.0 631000.0 0.69 6157160.0 538000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H15 compound treatment 6121840.0 715664.51612903 0.791317660158556 0.9813 0.9505 3187166 PK04_095153 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 5761920.0 308000.0 0.34 6187440.0 569000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H16 compound treatment 6010240.0 604064.51612903 0.667920385481083 0.9994 0.9755 3186978 PK04_095154 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 6065480.0 612000.0 0.67 6010400.0 392000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H17 compound treatment 5844280.0 438104.51612903 0.484416696363937 0.9002 0.9988 3187349 PK04_095155 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCCN(C)C)c3ccccc3C1=O 5941680.0 488000.0 0.53 6157040.0 538000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H18 compound treatment 5698600.0 292424.51612903 0.323336813075279 1.0198 0.9355 3068412 PK04_095156 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 5979120.0 526000.0 0.58 6483200.0 864000.0 0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H19 mock treatment 5941400.0 535224.51612903 0.591803285223043 0.563 0.8614 5666960.0 213000.0 0.23 5768000.0 149000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H20 mock treatment 5819600.0 413424.51612903 0.457127765010532 1.242 0.9649 6300120.0 847000.0 0.93 6383040.0 764000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H21 compound treatment 5453040.0 46864.5161290299 0.0518185803709747 0.1716 0.2409 3187512 PK04_095157 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 6010400.0 557000.0 0.61 5255680.0 -363000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H22 compound treatment 2681720.0 -2724455.48387097 -3.01245861729188 -5.092 -0.9997 3186806 PK04_095158 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2852360.0 -2600000.0 -2.85 2670840.0 -2950000.0 -2.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H23 compound treatment 5313800.0 -92375.4838709701 -0.102140528285758 -0.3884 -0.9035 3068599 PK04_095159 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NC4CC4)c5ccccc5C2=O 5123600.0 -330000.0 -0.36 5410320.0 -208000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 H24 compound treatment 4625040.0 -781135.48387097 -0.863709586590923 -1.4109 -0.9857 3187586 PK04_095160 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 4883040.0 -571000.0 -0.62 4667040.0 -952000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I01 compound treatment 5163320.0 -242855.48387097 -0.268527821237964 -1.2226 -0.914 3187165 PK04_095161 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 4552280.0 -901000.0 -0.99 4759840.0 -859000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I02 compound treatment 5078240.0 -327935.48387097 -0.362601657524338 -0.5786 -0.9908 3068418 PK04_095162 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5 5207480.0 -246000.0 -0.27 5250000.0 -369000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I03 compound treatment 5064040.0 -342135.48387097 -0.378302744445666 -0.5487 -0.8618 3187178 PK04_095163 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 4989600.0 -464000.0 -0.51 5555040.0 -63700.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I04 compound treatment 5836800.0 430624.51612903 0.476145982971576 0.2662 0.4973 3068019 PK04_095164 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 5604600.0 151000.0 0.17 5439000.0 -180000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I05 mock treatment 5015840.0 -390335.48387097 -0.431597983150453 -0.7053 -0.6245 4523600.0 -930000.0 -1.02 5846320.0 228000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I06 mock treatment 5234000.0 -172175.48387097 -0.190376213942231 0.25 0.4107 5979920.0 526000.0 0.58 5665680.0 46900.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I07 compound treatment 5017600.0 -388575.48387097 -0.429651932940485 -0.2477 -0.4753 3068542 PK04_095165 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3Cc4ccccc4C3)C(=O)c5ccccc25)c6ccc(CO)cc6)cc1 5263560.0 -190000.0 -0.21 5826800.0 208000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I08 compound treatment 5378200.0 -27975.4838709701 -0.0309327819664993 0.4412 0.6749 3187345 PK04_095166 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 5602200.0 149000.0 0.16 6248800.0 630000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I09 compound treatment 2217800.0 -3188375.48387097 -3.52541976127372 -6.0049 -0.9994 3067971 PK04_095167 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 2188760.0 -3260000.0 -3.58 2330560.0 -3290000.0 -3.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I10 compound treatment 5430880.0 24704.5161290299 0.0273160390909316 -0.1608 -0.3821 3068641 PK04_095168 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 5081520.0 -372000.0 -0.41 5720040.0 101000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I11 compound treatment 5593760.0 187584.51612903 0.207414140340634 0.3555 0.9016 3187358 PK04_095169 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 5529880.0 76300.0 0.08 5942320.0 324000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I12 compound treatment 5447280.0 41104.5161290299 0.045449688774718 0.501 0.6218 3068653 PK04_095170 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 5470080.0 16500.0 0.02 6420240.0 801000.0 0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I13 compound treatment 5367800.0 -38375.4838709701 -0.0424321695708516 -0.1729 -0.9236 3067962 PK04_095171 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 5326880.0 -127000.0 -0.14 5500840.0 -118000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I14 compound treatment 5464080.0 57904.5161290299 0.0640256225971333 0.0474 0.1139 3068606 PK04_095172 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 5196440.0 -257000.0 -0.28 5917400.0 299000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I15 compound treatment 5728720.0 322544.51612903 0.356640808714038 0.6771 0.9608 3068476 PK04_095173 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 5949360.0 496000.0 0.54 5890920.0 272000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I16 compound treatment 4137680.0 -1268495.48387097 -1.40258858109642 -1.3869 -0.8693 3186417 PK04_095174 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 5178400.0 -275000.0 -0.3 4923080.0 -696000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I17 compound treatment 5297680.0 -108495.48387097 -0.119964579072504 0.1732 0.4651 3187268 PK04_095175 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5CCCCC5 5522640.0 69000.0 0.08 5961800.0 343000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I18 compound treatment 5896760.0 490584.51612903 0.542444375352054 0.5677 0.7109 3187264 PK04_095176 CC(C)N1[C@H]([C@H](C(=O)NCC(F)(F)F)c2ccccc2C1=O)c3ccc(CO)cc3 5334440.0 -119000.0 -0.13 6188040.0 569000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I19 compound treatment 4011640.0 -1394535.48387097 -1.5419523131784 -2.6264 -0.995 3186499 PK04_095177 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc41)c5ccc(CO)cc5 4249120.0 -1200000.0 -1.32 3936760.0 -1680000.0 -1.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I20 compound treatment 5680800.0 274624.51612903 0.303655168906291 0.5656 0.9912 3068422 PK04_095178 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 5717000.0 263000.0 0.29 6004920.0 386000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I21 mock treatment 5103600.0 -302575.48387097 -0.334560843135264 0.2556 0.3575 6009760.0 556000.0 0.61 5786360.0 168000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I22 mock treatment 4960600.0 -445575.48387097 -0.492677422695109 -0.0978 -0.179 5638120.0 185000.0 0.2 5739600.0 121000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I23 compound treatment 5340320.0 -65855.4838709701 -0.0728170898946595 -0.1686 -0.9845 3068550 PK04_095179 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(C)C)C(=O)c3ccccc23)c4ccc(CO)cc4)cc1 5352880.0 -101000.0 -0.11 5510280.0 -108000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 I24 compound treatment 4811520.0 -594655.48387097 -0.657516721162113 -1.687 -0.9284 3187258 PK04_095180 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4Cc5ccccc5C4 4062720.0 -1390000.0 -1.52 4880200.0 -739000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J01 compound treatment 4587760.0 -818415.48387097 -0.90493046831114 -1.6205 -0.9997 3187273 PK04_095181 CC(C)CNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 4591040.0 -863000.0 -0.94 4664920.0 -954000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J02 compound treatment 5285360.0 -120815.48387097 -0.133586930542275 -0.6189 -0.8382 3186630 PK04_095182 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 5215680.0 -238000.0 -0.26 4943360.0 -675000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J03 compound treatment 5115720.0 -290455.48387097 -0.321159633734807 -0.3959 -0.9501 3187353 PK04_095183 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(=O)c3ccccc32)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 5328200.0 -125000.0 -0.14 5392280.0 -226000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J04 compound treatment 5433960.0 27784.5161290299 0.0307216269583745 0.2158 0.8211 3187588 PK04_095184 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)O)c3ccccc3C1=O 5672480.0 219000.0 0.24 5721800.0 103000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J05 mock treatment 5267160.0 -139015.48387097 -0.153710858849892 -0.0399 -0.2092 5430280.0 -23300.0 -0.03 5728480.0 110000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J06 mock treatment 5759000.0 352824.51612903 0.390121718008248 -0.1605 -0.2505 5269480.0 -184000.0 -0.2 5154000.0 -465000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J07 compound treatment 3903960.0 -1502215.48387097 -1.66101520329731 -2.3196 -0.9313 3186420 PK04_095185 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-])c(I)c1 4905280.0 -548000.0 -0.6 3868920.0 -1750000.0 -1.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J08 compound treatment 2408800.0 -2997375.48387097 -3.31422908507841 -5.4119 -0.9989 3186722 PK04_095186 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 2624320.0 -2830000.0 -3.1 2668280.0 -2950000.0 -2.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J09 compound treatment 2336760.0 -3069415.48387097 -3.39388445844548 -5.7015 -0.9992 3186426 PK04_095187 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 2366440.0 -3090000.0 -3.38 2529160.0 -3090000.0 -3.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J10 compound treatment 6024240.0 618064.51612903 0.683400330333096 0.8268 0.9057 3186639 PK04_095188 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 5605960.0 152000.0 0.17 6198440.0 580000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J11 compound treatment 5832120.0 425944.51612903 0.470971258549618 0.3444 0.4872 3187270 PK04_095189 CC(C)NC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 5175480.0 -278000.0 -0.3 6047280.0 429000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J12 compound treatment 6050200.0 644024.51612903 0.712104570930114 0.762 0.8728 3067980 PK04_095190 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)O)cc1 5902600.0 449000.0 0.49 5734400.0 116000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J13 compound treatment 3268360.0 -2137815.48387097 -2.36380469957869 -3.9386 -0.9519 3186421 PK04_095191 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 2602840.0 -2850000.0 -3.12 4287360.0 -1330000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J14 compound treatment 3902240.0 -1503935.48387097 -1.66291702509341 -3.2615 -0.994 3068150 PK04_095192 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 3481200.0 -1970000.0 -2.16 3799120.0 -1820000.0 -1.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J15 compound treatment 5751400.0 345224.51612903 0.381718319374298 0.7471 0.9945 3068598 PK04_095193 CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 5837680.0 384000.0 0.42 6108760.0 490000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J16 compound treatment 2402920.0 -3003255.48387097 -3.32073066191625 -5.6059 -0.9996 3068324 PK04_095194 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2450800.0 -3000000.0 -3.29 2529320.0 -3090000.0 -3.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J17 compound treatment 1782360.0 -3623815.48387097 -4.00689027458518 -6.4666 -0.9983 3067973 PK04_095195 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-] 2055560.0 -3400000.0 -3.72 2158760.0 -3460000.0 -3.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J18 compound treatment 5182760.0 -223415.48387097 -0.247032812100597 0.2466 0.3881 3068414 PK04_095196 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 5980760.0 527000.0 0.58 5715280.0 96500.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J19 compound treatment 5644200.0 238024.51612903 0.263186170221743 0.2097 0.4281 3187085 PK04_095197 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 5236480.0 -217000.0 -0.24 5955280.0 337000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J20 compound treatment 5851480.0 445304.51612903 0.492377810859258 0.568 0.7325 3186884 PK04_095198 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 5362920.0 -90700.0 -0.1 6207400.0 589000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J21 mock treatment 5680280.0 274104.51612903 0.303080199526073 0.3488 0.7891 5435280.0 -18300.0 -0.02 5938800.0 320000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J22 mock treatment 5604520.0 198344.51612903 0.219311583669753 0.3531 0.6497 5899240.0 446000.0 0.49 5523400.0 -95400.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J23 compound treatment 5246320.0 -159855.48387097 -0.17675386247246 -0.5128 -0.8894 3187082 PK04_095199 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4987120.0 -466000.0 -0.51 5418880.0 -200000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 J24 compound treatment 4747680.0 -658495.48387097 -0.728105269687291 -1.228 -0.9497 3068227 PK04_095200 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 4553760.0 -900000.0 -0.99 5206760.0 -412000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K01 compound treatment 2069960.0 -3336215.48387097 -3.68888797891098 -6.2175 -0.9996 3187514 PK04_095201 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-] 2139280.0 -3310000.0 -3.63 2180520.0 -3440000.0 -3.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K02 compound treatment 5161120.0 -245055.48387097 -0.270960384000423 -0.934 -0.9311 3187168 PK04_095202 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccc(OC(F)(F)F)cc4 4942640.0 -511000.0 -0.56 4834320.0 -784000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K03 compound treatment 2821160.0 -2585015.48387097 -2.85827836656584 -5.319 -0.9971 3068143 PK04_095203 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC5CC5)c6ccccc6C2=O 2354200.0 -3100000.0 -3.39 2669080.0 -2950000.0 -2.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K04 compound treatment 4506800.0 -899375.48387097 -0.994448777969637 -1.0748 -0.8402 3187275 PK04_095204 CN(C)CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 4721400.0 -732000.0 -0.8 5553720.0 -65000.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K05 compound treatment 5090560.0 -315615.48387097 -0.348979306054567 -0.249 -0.686 3187271 PK04_095205 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 5363520.0 -90100.0 -0.1 5635000.0 16200.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K06 compound treatment 5336160.0 -70015.4838709701 -0.0774168449364004 -0.4546 -0.7533 3186561 PK04_095206 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 5339840.0 -114000.0 -0.12 5035440.0 -583000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K07 mock treatment 5558560.0 152384.51612903 0.168493136141288 0.303 0.6098 5870440.0 417000.0 0.46 5518880.0 -99900.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K08 mock treatment 5513440.0 107264.51612903 0.118603485303944 0.4979 0.7783 5570840.0 117000.0 0.13 6231880.0 613000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K09 compound treatment 5792640.0 386464.51612903 0.427317814066942 0.0498 0.0888 3068519 PK04_095207 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 5122640.0 -331000.0 -0.36 5640080.0 21300.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K10 compound treatment 5446360.0 40184.5161290299 0.0444324352558715 0.38 0.8609 3068466 PK04_095208 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4C(F)(F)F 5690360.0 237000.0 0.26 5971880.0 353000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K11 compound treatment 5530680.0 124504.51612903 0.137665931678851 0.0243 0.0489 3068556 PK04_095209 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5CCCCC5 5104480.0 -349000.0 -0.38 5904560.0 286000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K12 compound treatment 1159800.0 -4246375.48387097 -4.69526130794726 -8.3636 -0.9978 3067978 PK04_095210 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-])c(I)c1 637720.0 -4820000.0 -5.27 1117880.0 -4500000.0 -4.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K13 compound treatment 5551320.0 145144.51612903 0.160487793232104 0.3423 0.9789 3068499 PK04_095211 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 5615440.0 162000.0 0.18 5873000.0 254000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K14 compound treatment 4627480.0 -778695.48387097 -0.861011653345287 -1.7164 -0.981 3068588 PK04_095212 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 4295760.0 -1160000.0 -1.27 4777840.0 -841000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K15 mock treatment 5640680.0 234504.51612903 0.259294069801809 0.7682 0.934 6064200.0 611000.0 0.67 6019840.0 401000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K16 mock treatment 5623600.0 217424.51612903 0.240408537082353 -0.1657 -0.3273 5055520.0 -398000.0 -0.44 5527640.0 -91100.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K17 compound treatment 2245680.0 -3160495.48387097 -3.49459255681129 -5.3204 -0.9923 3068009 PK04_095213 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 2572840.0 -2880000.0 -3.15 3062040.0 -2560000.0 -2.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K18 compound treatment 1522240.0 -3883935.48387097 -4.29450764993558 -5.3536 -0.9187 3186498 PK04_095214 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCCN(C)C)c5ccccc5C2=O 2039600.0 -3410000.0 -3.74 4383640.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K19 compound treatment 5994040.0 587864.51612903 0.650007877866611 0.647 0.861 3068472 PK04_095215 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4Cl 5782920.0 329000.0 0.36 5728360.0 110000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K20 compound treatment 5194680.0 -211495.48387097 -0.233852744769455 -0.221 -0.663 3187259 PK04_095216 COCCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 5248080.0 -206000.0 -0.23 5694600.0 75800.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K21 compound treatment 5079480.0 -326695.48387097 -0.361230576694589 0.0144 0.0318 3187078 PK04_095217 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 5631240.0 178000.0 0.19 5809720.0 191000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K22 compound treatment 5160920.0 -245255.48387097 -0.271181526069737 -0.0553 -0.1849 3068508 PK04_095218 COc1ccccc1CN2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 5548520.0 94900.0 0.1 5689960.0 71200.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K23 mock treatment 4959640.0 -446535.48387097 -0.493738904627818 -0.4164 -0.619 5073680.0 -380000.0 -0.42 5806680.0 188000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 K24 mock treatment 4934000.0 -472175.48387097 -0.522089317913933 -1.531 -0.9331 4229920.0 -1220000.0 -1.34 4831920.0 -787000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L01 compound treatment 4869840.0 -536335.48387097 -0.593031693750014 -0.6389 -0.9051 3187175 PK04_095219 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCCN(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 5140680.0 -313000.0 -0.34 5448400.0 -170000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L02 compound treatment 2310000.0 -3096175.48387097 -3.42347326731975 -6.0346 -0.9996 3186714 PK04_095220 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 2144560.0 -3310000.0 -3.62 2225920.0 -3390000.0 -3.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L03 compound treatment 5123440.0 -282735.48387097 -0.312623549859269 -0.6325 -0.9199 3067967 PK04_095221 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCc3ccccc3)c4ccc(cc4)[N+](=O)[O-] 5265200.0 -188000.0 -0.21 5044280.0 -574000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L04 compound treatment 5494240.0 88064.5161290299 0.0973738466497551 -0.088 -0.411 3186429 PK04_095222 CC(C)CN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 5385960.0 -67600.0 -0.07 5443680.0 -175000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L05 compound treatment 5881920.0 475744.51612903 0.52603563380892 0.4138 0.5733 3068540 PK04_095223 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 5847600.0 394000.0 0.43 5378800.0 -240000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L06 compound treatment 5160320.0 -245855.48387097 -0.271844952277681 -0.1532 -0.3726 3186551 PK04_095224 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 5655640.0 202000.0 0.22 5404840.0 -214000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L07 mock treatment 5636000.0 229824.51612903 0.25411934537985 0.2654 0.7022 5701800.0 248000.0 0.27 5552760.0 -66000.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L08 mock treatment 5497920.0 91744.5161290299 0.101442860725141 0.2437 0.8421 5695880.0 242000.0 0.27 5673880.0 55100.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L09 compound treatment 3602320.0 -1803855.48387097 -1.99454167223739 -2.693 -0.9652 3187518 PK04_095225 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 3917080.0 -1540000.0 -1.68 4635160.0 -984000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L10 compound treatment 5775120.0 368944.51612903 0.407945768794994 0.621 0.9857 3068144 PK04_095226 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCc5ccccc5)c6ccccc6C2=O 5702080.0 248000.0 0.27 6012920.0 394000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L11 compound treatment 5593560.0 187384.51612903 0.20719299827132 0.1601 0.7496 3187076 PK04_095227 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 5476280.0 22700.0 0.02 5663800.0 45000.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L12 compound treatment 2671440.0 -2734735.48387097 -3.02382531965465 -4.9873 -0.9912 3068313 PK04_095228 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2475840.0 -2980000.0 -3.26 3273760.0 -2350000.0 -2.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L13 compound treatment 5646400.0 240224.51612903 0.265618732984202 0.9223 0.9206 3187347 PK04_095229 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(C)C)C(=O)c3ccccc32)c4ccc(CO)cc4)cc1 5922880.0 469000.0 0.51 6433800.0 815000.0 0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L14 compound treatment 5662320.0 256144.51612903 0.283221641701634 0.7021 0.9729 3068194 PK04_095230 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(C)C)C4=O)c6ccccc6C2=O 5927360.0 474000.0 0.52 6031360.0 413000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L15 mock treatment 5567600.0 161424.51612903 0.178488757674302 0.1959 0.7587 5431520.0 -22100.0 -0.02 5803080.0 184000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L16 mock treatment 5731520.0 325344.51612903 0.35973679768444 0.7743 0.9563 6038040.0 584000.0 0.64 5958960.0 340000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L17 compound treatment 5487360.0 81184.5161290299 0.0897665594653374 0.2208 0.8026 3068510 PK04_095231 COc1ccccc1CN2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 5485560.0 32000.0 0.04 5875520.0 257000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L18 compound treatment 2571360.0 -2834815.48387097 -3.13448481113961 -5.014 -0.9741 3068263 PK04_095232 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3I)Sc4ccc(C)cc4)cc1 2192040.0 -3260000.0 -3.57 3647600.0 -1970000.0 -1.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L19 compound treatment 5596600.0 190424.51612903 0.2105543577249 0.5513 0.9705 3067958 PK04_095233 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-] 5817240.0 364000.0 0.4 5963640.0 345000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L20 compound treatment 5834880.0 428704.51612903 0.474023019106157 0.478 0.8906 3068403 PK04_095234 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 5633000.0 179000.0 0.2 5775600.0 157000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L21 compound treatment 5895080.0 488904.51612903 0.540586781969812 0.2813 0.4019 3187163 PK04_095235 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 5143320.0 -310000.0 -0.34 5904120.0 285000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L22 compound treatment 5194320.0 -211855.48387097 -0.234250800494221 -0.2363 -0.6852 3186433 PK04_095236 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c5ccc(cc5)[N+](=O)[O-] 5231200.0 -222000.0 -0.24 5687120.0 68400.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L23 mock treatment 5291600.0 -114575.48387097 -0.126687297979664 -0.2745 -0.7664 5440800.0 -12800.0 -0.01 5285240.0 -334000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 L24 mock treatment 4785520.0 -620655.48387097 -0.686265190172994 -1.2761 -0.9444 4473760.0 -980000.0 -1.07 5169400.0 -449000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M01 compound treatment 4689480.0 -716695.48387097 -0.792457611857802 -1.1662 -0.9868 3187444 PK04_095237 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 4813160.0 -640000.0 -0.7 5094560.0 -524000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M02 compound treatment 5163320.0 -242855.48387097 -0.268527821237964 -0.2704 -0.7629 3068593 PK04_095238 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NC3CC3)c4ccccc4C1=O 5480640.0 27000.0 0.03 5390200.0 -229000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M03 compound treatment 5474760.0 68584.5161290299 0.0758346090985259 -0.299 -0.6801 3187441 PK04_095239 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 5114000.0 -340000.0 -0.37 5397760.0 -221000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M04 compound treatment 4541120.0 -865055.48387097 -0.956500798875274 -1.0801 -0.9355 3068649 PK04_095240 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 5047560.0 -406000.0 -0.44 5150800.0 -468000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M05 compound treatment 5281760.0 -124415.48387097 -0.137567487789936 -0.3459 -0.493 3068152 PK04_095241 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 5634000.0 180000.0 0.2 4961960.0 -657000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M06 compound treatment 5146800.0 -259375.48387097 -0.286794156163339 -0.1503 -0.5146 3068655 PK04_095242 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 5432040.0 -21600.0 -0.02 5668640.0 49900.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M07 compound treatment 5304840.0 -101335.48387097 -0.112047692991046 0.2384 0.3329 3068005 PK04_095243 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 6082080.0 628000.0 0.69 5456080.0 -163000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M08 compound treatment 5897680.0 491504.51612903 0.5434616288709 0.7621 0.8777 3187084 PK04_095244 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 5552280.0 98700.0 0.11 6284880.0 666000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M09 mock treatment 5596360.0 190184.51612903 0.210288987241723 0.8576 0.897 6189800.0 736000.0 0.81 6086000.0 467000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M10 mock treatment 5735120.0 328944.51612903 0.363717354932101 0.9149 0.9659 5920920.0 467000.0 0.51 6325440.0 707000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M11 compound treatment 3084480.0 -2321695.48387097 -2.56712271810641 -4.7944 -0.9826 3186422 PK04_095245 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 2271160.0 -3180000.0 -3.49 3374920.0 -2240000.0 -2.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M12 compound treatment 2105800.0 -3300375.48387097 -3.64925932008983 -4.8754 -0.9373 3068142 PK04_095246 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 2297320.0 -3160000.0 -3.46 4284840.0 -1330000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M13 mock treatment 5456920.0 50744.5161290299 0.0561087365156754 0.537 0.7922 6028800.0 575000.0 0.63 5862000.0 243000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M14 mock treatment 5930800.0 524624.51612903 0.580082755549376 0.9865 0.9971 6016680.0 563000.0 0.62 6128920.0 510000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M15 compound treatment 5470400.0 64224.5161290299 0.0710137119874705 0.8575 0.8517 3068557 PK04_095247 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5CCCCC5 6039080.0 585000.0 0.64 6389120.0 770000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M16 compound treatment 5325240.0 -80935.4838709701 -0.0894912019209704 0.8971 0.7664 3187170 PK04_095248 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 6133320.0 680000.0 0.74 6514440.0 896000.0 0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M17 compound treatment 4537320.0 -868855.48387097 -0.960702498192249 -1.125 -0.9164 3187431 PK04_095249 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 4802240.0 -651000.0 -0.71 5345280.0 -273000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M18 compound treatment 5759720.0 353544.51612903 0.39091782945778 0.2628 0.524 3187074 PK04_095250 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 5282160.0 -171000.0 -0.19 5869920.0 251000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M19 compound treatment 5649280.0 243104.51612903 0.268803178782331 0.4784 0.9841 3068552 PK04_095251 CC(C)NC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 5653760.0 200000.0 0.22 5958240.0 339000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M20 compound treatment 5694600.0 288424.51612903 0.318913971688989 0.5157 0.9169 3068014 PK04_095252 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)O)c5ccccc5C2=O 5859760.0 406000.0 0.44 5747800.0 129000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M21 compound treatment 5771800.0 365624.51612903 0.404274810444374 0.2961 0.7175 3187086 PK04_095253 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 5523720.0 70100.0 0.08 5650520.0 31800.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M22 compound treatment 4646360.0 -759815.48387097 -0.840135842002001 -1.7539 -0.9928 3187428 PK04_095254 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 4441200.0 -1010000.0 -1.11 4533680.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M23 compound treatment 5379320.0 -26855.4838709701 -0.0296943863783382 -0.8591 -0.6333 3187081 PK04_095255 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 5356600.0 -97000.0 -0.11 4271480.0 -1350000.0 -1.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 M24 compound treatment 4568760.0 -837415.48387097 -0.925938964896015 -1.38 -0.9858 3068003 PK04_095256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 4673200.0 -780000.0 -0.85 5011360.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N01 compound treatment 5859360.0 453184.51612903 0.501090808390248 0.2895 0.3065 3187360 PK04_095257 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 5970600.0 517000.0 0.57 5054880.0 -564000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N02 compound treatment 5980600.0 574424.51612903 0.635147130808679 0.1729 0.2511 3068231 PK04_095258 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 5378160.0 -75400.0 -0.08 5366680.0 -252000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N03 compound treatment 5709440.0 303264.51612903 0.335322713232123 0.2989 0.8259 3068544 PK04_095259 CC(C)NC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 5508760.0 55200.0 0.06 5740320.0 122000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N04 compound treatment 4256040.0 -1150135.48387097 -1.27171670447612 -2.9505 -0.9778 3187527 PK04_095260 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-] 3477960.0 -1980000.0 -2.16 3949680.0 -1670000.0 -1.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N05 compound treatment 5741480.0 335304.51612903 0.370749672736301 1.0059 0.8579 3187260 PK04_095261 CCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 6431440.0 978000.0 1.07 5918280.0 300000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N06 compound treatment 3003160.0 -2403015.48387097 -2.65703908348967 -4.5305 -0.9851 3186724 PK04_095262 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 2574680.0 -2880000.0 -3.15 3588800.0 -2030000.0 -2.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N07 compound treatment 5821920.0 415744.51612903 0.45969301301458 1.3015 0.8828 3068501 PK04_095263 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 5889760.0 436000.0 0.48 6931000.0 1310000.0 1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N08 compound treatment 5864600.0 458424.51612903 0.506884730606287 0.6897 0.8915 3186871 PK04_095264 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 5976880.0 523000.0 0.57 5733000.0 114000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N09 mock treatment 5547440.0 141264.51612903 0.156197637087404 0.3843 0.9608 5636840.0 183000.0 0.2 5926400.0 308000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N10 mock treatment 5837280.0 431104.51612903 0.476676723937931 0.7091 0.9089 5593440.0 140000.0 0.15 6215000.0 596000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N11 compound treatment 5637920.0 231744.51612903 0.256242309245269 0.4694 0.7921 3187070 PK04_095265 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4 5941080.0 487000.0 0.53 5641600.0 22800.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N12 compound treatment 2990880.0 -2415295.48387097 -2.67061720654558 -4.3447 -0.9789 3186804 PK04_095266 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2666440.0 -2790000.0 -3.05 3822880.0 -1800000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N13 mock treatment 7222840.0 1816664.51612903 2.0087047517347 2.3834 0.8698 7137000.0 1680000.0 1.84 5893800.0 275000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N14 mock treatment 5880480.0 474304.51612903 0.524443410909856 2.1212 0.7985 7763320.0 2310000.0 2.53 6236760.0 618000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N15 compound treatment 1317560.0 -4088615.48387097 -4.52082444367201 -7.4812 -0.9992 3186424 PK04_095267 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1496760.0 -3960000.0 -4.33 1529680.0 -4090000.0 -4.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N16 compound treatment 5842480.0 436304.51612903 0.482426417740107 0.854 0.9276 3068226 PK04_095268 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 5686680.0 233000.0 0.26 6357560.0 739000.0 0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N17 compound treatment 5271280.0 -134895.48387097 -0.149155332222014 -0.376 -0.7549 3068455 PK04_095269 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 5020400.0 -433000.0 -0.47 5591160.0 -27600.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N18 compound treatment 5291160.0 -115015.48387097 -0.127173810532156 0.15 0.4947 3068137 PK04_095270 CN(C)CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 5611160.0 158000.0 0.17 5832400.0 214000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N19 compound treatment 5441760.0 35584.5161290299 0.0393461676616387 -0.1317 -0.4749 3068647 PK04_095271 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 5203040.0 -251000.0 -0.27 5625680.0 6920.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N20 compound treatment 5091720.0 -314455.48387097 -0.347696682052543 -0.1301 -0.2049 3186492 PK04_095272 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 5847760.0 394000.0 0.43 5310600.0 -308000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N21 compound treatment 4953200.0 -452975.48387097 -0.500859679259744 -0.7798 -0.9931 3067959 PK04_095273 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 5021560.0 -432000.0 -0.47 5243480.0 -375000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N22 compound treatment 5719480.0 313304.51612903 0.346424045111709 0.1664 0.3817 3187526 PK04_095274 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)O)c3ccc(cc3)[N+](=O)[O-] 5595760.0 142000.0 0.16 5405600.0 -213000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N23 compound treatment 5449880.0 43704.5161290299 0.0483245356758061 -0.0409 -0.0839 3068468 PK04_095275 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 5707720.0 254000.0 0.28 5222720.0 -396000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 N24 compound treatment 4594440.0 -811735.48387097 -0.897544323196037 -1.5326 -0.9656 3068222 PK04_095276 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 4917880.0 -536000.0 -0.59 4452600.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O01 compound treatment 4189680.0 -1216495.48387097 -1.34509164307466 -2.3224 -0.9872 3068590 PK04_095277 CC(C)NC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 3988640.0 -1460000.0 -1.6 4549520.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O02 compound treatment 2685880.0 -2720295.48387097 -3.00785886225014 -5.4544 -0.9981 3067977 PK04_095278 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 2326080.0 -3130000.0 -3.43 2615120.0 -3000000.0 -3.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O03 compound treatment 5461520.0 55344.5161290299 0.0611950041099082 0.1568 0.3388 3068512 PK04_095279 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 5829800.0 376000.0 0.41 5417840.0 -201000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O04 compound treatment 5147680.0 -258495.48387097 -0.285821131058355 -0.3294 -0.922 3068637 PK04_095280 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 5371160.0 -82400.0 -0.09 5425080.0 -194000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O05 compound treatment 5030960.0 -375215.48387097 -0.414879642710279 -0.2136 -0.3144 3068459 PK04_095281 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F 5127480.0 -326000.0 -0.36 6019440.0 401000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O06 compound treatment 4670160.0 -736015.48387097 -0.813819935753579 -0.5696 -0.6743 3187520 PK04_095282 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)O)cc1 5251720.0 -202000.0 -0.22 5666960.0 48200.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O07 compound treatment 4874880.0 -531295.48387097 -0.58745891360329 0.2671 0.2764 3186989 PK04_095283 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5 6058560.0 605000.0 0.66 6005000.0 386000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O08 compound treatment 5110040.0 -296135.48387097 -0.327440068503338 -0.7081 -0.9867 3187364 PK04_095284 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 5082480.0 -371000.0 -0.41 5127880.0 -491000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O09 compound treatment 5184520.0 -221655.48387097 -0.24508676189063 -0.4393 -0.9955 3068604 PK04_095285 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 5244080.0 -210000.0 -0.23 5333360.0 -285000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O10 compound treatment 5690240.0 284064.51612903 0.314093074577934 0.4891 0.954 3187362 PK04_095286 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 5793040.0 339000.0 0.37 5779520.0 161000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O11 mock treatment 5914760.0 508584.51612903 0.562347161590356 0.5725 0.8951 5666760.0 213000.0 0.23 5813800.0 195000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O12 mock treatment 5910000.0 503824.51612903 0.557083980340671 0.5853 0.8851 5759400.0 306000.0 0.33 5740120.0 121000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O13 compound treatment 5003680.0 -402495.48387097 -0.445043420964772 -1.2279 -0.956 3068644 PK04_095287 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 4560640.0 -893000.0 -0.98 4917360.0 -701000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O14 compound treatment 5883920.0 477744.51612903 0.528247054502065 0.6569 0.9492 3068464 PK04_095288 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 5808760.0 355000.0 0.39 5838600.0 220000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O15 compound treatment 2263280.0 -3142895.48387097 -3.47513205471161 -6.1532 -0.9982 3187516 PK04_095289 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-] 1944240.0 -3510000.0 -3.84 2291360.0 -3330000.0 -3.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O16 compound treatment 5361400.0 -44775.4838709701 -0.0495087157889146 -0.1724 -0.4235 3187164 PK04_095290 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 5574720.0 121000.0 0.13 5238320.0 -380000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O17 compound treatment 5734600.0 328424.51612903 0.363142385551883 0.4481 0.5361 3187177 PK04_095291 CC(C)CNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 6090240.0 637000.0 0.7 5335560.0 -283000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O18 compound treatment 5736360.0 330184.51612903 0.36508843576185 0.5379 0.9847 3068546 PK04_095292 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 5668400.0 215000.0 0.24 5948960.0 330000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O19 compound treatment 5771200.0 365024.51612903 0.403611384236431 0.3571 0.7108 3187256 PK04_095293 CC(C)CNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 5385320.0 -68300.0 -0.07 5907440.0 289000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O20 compound treatment 5347880.0 -58295.4838709701 -0.0644579196745726 0.1558 0.5513 3187088 PK04_095294 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 5697160.0 244000.0 0.27 5686080.0 67300.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O21 compound treatment 4194920.0 -1211255.48387097 -1.33929772085862 -2.0252 -0.9779 3186494 PK04_095295 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(C)C)c5ccccc5C2=O 4708720.0 -745000.0 -0.82 4270800.0 -1350000.0 -1.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O22 compound treatment 4943240.0 -462935.48387097 -0.511872554311605 -0.7892 -0.9092 3187161 PK04_095296 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 5292320.0 -161000.0 -0.18 4942800.0 -676000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O23 compound treatment 4771520.0 -634655.48387097 -0.701745135025007 -0.3436 -0.3496 3187267 PK04_095297 CC(C)CNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 5943920.0 490000.0 0.54 5189880.0 -429000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 O24 compound treatment 4299960.0 -1106215.48387097 -1.22315390605466 -1.8159 -0.9931 3068502 PK04_095298 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 4565440.0 -888000.0 -0.97 4672720.0 -946000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P01 compound treatment 4212440.0 -1193735.48387097 -1.31992567558667 -2.1866 -0.9987 3068591 PK04_095299 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2CC4(CC5CC6CC(C5)C4)C6 4272040.0 -1180000.0 -1.29 4449480.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P02 compound treatment 4972000.0 -434175.48387097 -0.480072324744184 -0.722 -0.8943 3187521 PK04_095300 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 5329640.0 -124000.0 -0.14 4986280.0 -632000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P03 compound treatment 4692400.0 -713775.48387097 -0.78922893764581 -1.2691 -0.9598 3186990 PK04_095301 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 5045640.0 -408000.0 -0.45 4660080.0 -959000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P04 compound treatment 5025720.0 -380455.48387097 -0.420673564926318 -0.3482 -0.4778 3186985 PK04_095302 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 5745400.0 292000.0 0.32 5118560.0 -500000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P05 compound treatment 1917200.0 -3488975.48387097 -3.85779629145337 -7.1542 -0.9957 3067579 PK04_095303 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-])c(I)c1 1187680.0 -4270000.0 -4.67 1770520.0 -3850000.0 -3.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P06 compound treatment 5441440.0 35264.5161290299 0.0389923403507356 -0.4155 -0.7301 3186975 PK04_095304 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 4987120.0 -466000.0 -0.51 5371800.0 -247000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P07 compound treatment 5348800.0 -57375.4838709701 -0.0634406661557261 0.1191 0.2041 3068548 PK04_095305 CC(C)CNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 5930400.0 477000.0 0.52 5367200.0 -252000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P08 compound treatment 5119240.0 -286935.48387097 -0.317267533314873 -0.6836 -0.8065 3067563 PK04_095306 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CCN5CCOCC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 5375640.0 -78000.0 -0.09 4840120.0 -779000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P09 compound treatment 5179800.0 -226375.48387097 -0.250305714726452 -0.8306 -0.9473 3067961 PK04_095307 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-] 4904040.0 -550000.0 -0.6 5034280.0 -584000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P10 compound treatment 5171800.0 -234375.48387097 -0.25915139749903 -0.1219 -0.1647 3068015 PK04_095308 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 5922840.0 469000.0 0.51 5154480.0 -464000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P11 mock treatment 5667840.0 261664.51612903 0.289325162814713 0.0375 0.1079 5421680.0 -31900.0 -0.03 5430040.0 -189000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P12 mock treatment 5734520.0 328344.51612903 0.363053928724157 0.37 0.7289 5771120.0 318000.0 0.35 5549040.0 -69700.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P13 compound treatment 4365120.0 -1041055.48387097 -1.15110581987201 -1.9721 -0.9003 3187510 PK04_095309 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 5035000.0 -419000.0 -0.46 3818920.0 -1800000.0 -1.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P14 compound treatment 3116320.0 -2289855.48387097 -2.53191690067154 -3.5855 -0.955 3186495 PK04_095310 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCN5CCOCC5)c6ccccc6C2=O 4393480.0 -1060000.0 -1.16 3110400.0 -2510000.0 -2.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P15 compound treatment 5377720.0 -28455.4838709701 -0.031463522932854 0.0458 0.1322 3187437 PK04_095311 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 5721280.0 268000.0 0.29 5437120.0 -182000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P16 compound treatment 5037320.0 -368855.48387097 -0.407847324906079 -0.574 -0.9199 3186625 PK04_095312 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C(C)C)C4=O)c6ccccc6C2=O 5331880.0 -122000.0 -0.13 5167320.0 -451000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P17 compound treatment 4745160.0 -661015.48387097 -0.730891659760654 -1.1349 -0.6197 3068541 PK04_095313 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 5815840.0 362000.0 0.4 3993000.0 -1630000.0 -1.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P18 compound treatment 5033800.0 -372375.48387097 -0.411739425326013 -0.5046 -0.8907 3186878 PK04_095314 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NC6CC6)cc1 5378840.0 -74800.0 -0.08 5239760.0 -379000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P19 compound treatment 3015400.0 -2390775.48387097 -2.64350518884763 -4.9566 -0.9969 3187513 PK04_095315 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 2555880.0 -2900000.0 -3.17 2860480.0 -2760000.0 -2.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P20 compound treatment 2364760.0 -3041415.48387097 -3.36292456874145 -6.0669 -0.9991 3068271 PK04_095316 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCc6ccccc6)cc1 2068160.0 -3390000.0 -3.71 2193200.0 -3430000.0 -3.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P21 compound treatment 1945640.0 -3460535.48387097 -3.82634988919685 -6.4301 -0.9994 3068008 PK04_095317 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 2003800.0 -3450000.0 -3.78 2098320.0 -3520000.0 -3.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P22 compound treatment 2029400.0 -3376775.48387097 -3.73373559056795 -6.4995 -0.9991 3068262 PK04_095318 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 1837960.0 -3620000.0 -3.96 2067240.0 -3550000.0 -3.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P23 compound treatment 4410760.0 -995415.48387097 -1.10064119965444 -1.7529 -0.9962 3068469 PK04_095319 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 4640320.0 -813000.0 -0.89 4577720.0 -1040000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2095 P24 compound treatment 1818520.0 -3587655.48387097 -3.96690778845313 -7.0537 -0.9995 3186794 PK04_095320 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1572240.0 -3880000.0 -4.25 1633120.0 -3990000.0 -4.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A01 compound treatment 2450520.0 -3032476.72131148 -3.35304088649387 -4.9666 -0.9888 3186490 PK04_096001 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 2315480.0 -2690000.0 -2.95 2292560.0 -2300000.0 -2.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A02 compound treatment 4030200.0 -1452796.72131148 -1.60637236622048 -2.5561 -0.9821 3186641 PK04_096002 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 3418440.0 -1590000.0 -1.74 3508800.0 -1080000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A03 compound treatment 2083280.0 -3399716.72131148 -3.7591019541691 -4.4024 -0.9472 3068261 PK04_096003 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 3246360.0 -1760000.0 -1.93 2655000.0 -1930000.0 -1.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A04 compound treatment 4102600.0 -1380396.72131148 -1.52631893712864 -1.9865 -0.9714 3186971 PK04_096004 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4040680.0 -965000.0 -1.06 3732960.0 -855000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A05 compound treatment 4020440.0 -1462556.72131148 -1.61716409920302 -2.1159 -0.9601 3186883 PK04_096005 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 3824720.0 -1180000.0 -1.29 3835800.0 -752000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A06 compound treatment 1625200.0 -3857796.72131148 -4.26560574972696 -6.1156 -0.9882 3068309 PK04_096006 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1927200.0 -3080000.0 -3.37 1642560.0 -2950000.0 -2.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A07 compound treatment 1837360.0 -3645636.72131148 -4.03101824259817 -6.0728 -0.9905 3186716 PK04_096007 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1691040.0 -3310000.0 -3.63 1740360.0 -2850000.0 -2.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A08 compound treatment 3808240.0 -1674756.72131148 -1.85179583474567 -2.9295 -0.9832 3068367 PK04_096008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)Sc6ccc(C)cc6)cc1 3206880.0 -1800000.0 -1.97 3339640.0 -1250000.0 -1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A09 compound treatment 4729840.0 -753156.72131148 -0.832773179344604 -1.8517 -0.9855 3068224 PK04_096009 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 3834240.0 -1170000.0 -1.28 3499920.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A10 compound treatment 4315760.0 -1167236.72131148 -1.29062571965328 -1.7006 -0.9759 3186633 PK04_096010 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5C(F)(F)F)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 4221600.0 -784000.0 -0.86 3794120.0 -794000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A11 compound treatment 4528240.0 -954756.72131148 -1.05568438521359 -1.6776 -0.9947 3186986 PK04_096011 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 4072200.0 -933000.0 -1.02 3762760.0 -825000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A12 compound treatment 4506960.0 -976036.72131148 -1.07921390138865 -1.9026 -0.9886 3186640 PK04_096012 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 3806920.0 -1200000.0 -1.31 3687400.0 -900000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A13 mock treatment 4782480.0 -700516.72131148 -0.774568586701036 -1.74 -0.9553 3686600.0 -1320000.0 -1.44 3795800.0 -792000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A14 mock treatment 4460880.0 -1022116.72131148 -1.1301650341587 -1.8555 -0.9963 3962000.0 -1040000.0 -1.14 3650200.0 -938000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A15 compound treatment 4539440.0 -943556.72131148 -1.04330042933198 -1.2089 -0.9393 3186881 PK04_096013 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 4443880.0 -562000.0 -0.61 4153760.0 -434000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A16 compound treatment 2318240.0 -3164756.72131148 -3.49930425113846 -5.33 -0.9913 3186790 PK04_096014 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2077280.0 -2930000.0 -3.21 2071000.0 -2520000.0 -2.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A17 compound treatment 4525560.0 -957436.72131148 -1.0586476889424 -1.7559 -0.9731 3186485 PK04_096015 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 3833920.0 -1170000.0 -1.28 3890640.0 -697000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A18 compound treatment 1629280.0 -3853716.72131148 -4.26109445151294 -6.2003 -0.9883 3186802 PK04_096016 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1743080.0 -3260000.0 -3.57 1692720.0 -2900000.0 -2.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A19 compound treatment 4406720.0 -1076276.72131148 -1.19005030652906 -1.739 -0.9779 3068405 PK04_096017 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 3983560.0 -1020000.0 -1.12 3887360.0 -700000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A20 compound treatment 4120880.0 -1362116.72131148 -1.5061065519933 -2.0535 -0.9783 3068141 PK04_096018 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 3948840.0 -1060000.0 -1.16 3697440.0 -890000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A21 compound treatment 4133080.0 -1349916.72131148 -1.49261688576511 -2.4458 -0.9972 3186624 PK04_096019 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5OC)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 3653720.0 -1350000.0 -1.48 3329080.0 -1260000.0 -1.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A22 compound treatment 4188520.0 -1294476.72131148 -1.43131630415114 -2.213 -0.9934 3068200 PK04_096020 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCCN(C)C)C4=O)c6ccccc6C2=O 4021240.0 -984000.0 -1.08 3268600.0 -1320000.0 -1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A23 compound treatment 4064640.0 -1418356.72131148 -1.56829170188452 -2.2252 -0.9876 3068358 PK04_096021 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 3917960.0 -1090000.0 -1.19 3496760.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 A24 compound treatment 4413600.0 -1069396.72131148 -1.18244301934464 -2.0783 -0.9983 3068371 PK04_096022 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 3824080.0 -1180000.0 -1.29 3468320.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B01 compound treatment 4376840.0 -1106156.72131148 -1.22308893168464 -1.6606 -0.9696 3187511 PK04_096023 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCC(F)(F)F)c3ccc(cc3)[N+](=O)[O-] 4078640.0 -927000.0 -1.01 3951920.0 -636000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B02 compound treatment 4507360.0 -975636.72131148 -1.07877161725002 -1.8542 -0.96 3187030 PK04_096024 OCCCc1cc[n+](Cc2cccc(OC(F)(F)F)c2)cc1 3682400.0 -1320000.0 -1.45 3906280.0 -682000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B03 compound treatment 4522680.0 -960316.72131148 -1.06183213474053 -1.3638 -0.9709 3187169 PK04_096025 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 4412360.0 -593000.0 -0.65 3939280.0 -649000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B04 compound treatment 4522360.0 -960636.72131148 -1.06218596205143 -1.3873 -0.9211 3068853 PK04_096026 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C)c2cc1O 4075880.0 -930000.0 -1.02 4266240.0 -322000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B05 compound treatment 4712000.0 -770996.72131148 -0.852499051927455 -1.3902 -0.9965 3068457 PK04_096027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 4359960.0 -645000.0 -0.71 3742400.0 -845000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B06 compound treatment 5321920.0 -161076.72131148 -0.178104197346053 -0.7723 -0.9204 3068854 PK04_096028 C[n+]1ccc2ccc(O)cc2c1 4472280.0 -533000.0 -0.58 4014240.0 -574000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B07 compound treatment 4893800.0 -589196.72131148 -0.651480910920603 -1.1798 -0.9982 3187352 PK04_096029 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCCN4CCOCC4)c5ccccc5C2=O 4409200.0 -596000.0 -0.65 3851400.0 -736000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B08 compound treatment 4706760.0 -776236.72131148 -0.858292974143494 -1.2497 -0.9788 3187112 PK04_096030 COc1cc2CC[N+](=Cc2cc1O)Cc3cc4OCOc4cc3Br 4279520.0 -726000.0 -0.79 4078320.0 -510000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B09 compound treatment 4764640.0 -718356.72131148 -0.794294459283887 -1.2443 -0.9526 3068505 PK04_096031 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 4134560.0 -871000.0 -0.95 4182120.0 -406000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B10 compound treatment 5070440.0 -412556.72131148 -0.456168235302065 -0.6849 -0.9463 3068855 PK04_096032 C[n+]1ccc(CCCO)cc1 4528760.0 -477000.0 -0.52 4380480.0 -207000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B11 compound treatment 4989520.0 -493476.72131148 -0.545642316546699 -0.6953 -0.9647 3068374 PK04_096033 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 4659640.0 -346000.0 -0.38 4308880.0 -279000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B12 compound treatment 2880280.0 -2602716.72131148 -2.87785080795094 -4.9952 -0.9976 3187113 PK04_096034 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C=C)c2cc1O 2143320.0 -2860000.0 -3.13 1957600.0 -2630000.0 -2.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B13 mock treatment 4879840.0 -603156.72131148 -0.666916627358753 -0.7555 -0.9334 4669400.0 -336000.0 -0.37 4315200.0 -273000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B14 mock treatment 4906520.0 -576476.72131148 -0.637416275312203 -0.7462 -0.898 4535920.0 -470000.0 -0.51 4447520.0 -140000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B15 compound treatment 5605640.0 122643.27868852 0.135607942183452 -0.4538 -0.6815 3187255 PK04_096035 COCCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 4572200.0 -433000.0 -0.47 4142240.0 -446000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B16 compound treatment 4748160.0 -734836.72131148 -0.812516565795399 -1.3542 -0.9734 3068856 PK04_096036 Oc1ccc2cc[n+](Cc3sc4ccccc4c3Cl)cc2c1 4101280.0 -904000.0 -0.99 4046880.0 -541000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B17 compound treatment 5224160.0 -258836.72131148 -0.286198440826965 -0.8451 -0.9598 3068608 PK04_096037 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 4469960.0 -535000.0 -0.59 3998800.0 -589000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B18 compound treatment 1576600.0 -3906396.72131148 -4.31934327257037 -6.753 -0.9939 3187114 PK04_096038 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C5CC5)c2cc1O 1285560.0 -3720000.0 -4.07 1296080.0 -3290000.0 -3.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B19 compound treatment 4898920.0 -584076.72131148 -0.645819673946153 -0.8674 -0.9577 3187171 PK04_096039 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 4737600.0 -268000.0 -0.29 4026560.0 -561000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B20 compound treatment 5050320.0 -432676.72131148 -0.4784151274751 -1.0186 -0.9791 3068857 PK04_096040 OCCCc1cc[n+](Cc2ccc(o2)[N+](=O)[O-])cc1 4312880.0 -693000.0 -0.76 4062360.0 -525000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B21 compound treatment 4834760.0 -648236.72131148 -0.716762049782234 -0.8615 -0.8598 3068424 PK04_096041 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4370200.0 -635000.0 -0.7 4508320.0 -79500.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B22 compound treatment 4638920.0 -844076.72131148 -0.933304364054961 -1.3317 -0.9875 3187115 PK04_096042 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C)c2cc1O 4421480.0 -584000.0 -0.64 3856640.0 -731000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B23 compound treatment 5036160.0 -446836.72131148 -0.494071985982565 -1.0166 -0.9901 3187072 PK04_096043 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4369760.0 -636000.0 -0.7 4019280.0 -569000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 B24 compound treatment 4428080.0 -1054916.72131148 -1.16643233352627 -2.1168 -0.9803 3187116 PK04_096044 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)c3cccs3 3592120.0 -1410000.0 -1.55 3639040.0 -949000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C01 compound treatment 4067720.0 -1415276.72131148 -1.56488611401708 -2.009 -0.9651 3068218 PK04_096045 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 3985280.0 -1020000.0 -1.12 3793040.0 -795000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C02 compound treatment 3978360.0 -1504636.72131148 -1.66369239058679 -1.8176 -0.9233 3186566 PK04_096046 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 4375480.0 -630000.0 -0.69 3796120.0 -792000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C03 compound treatment 4749920.0 -733076.72131148 -0.810570515585431 -1.0974 -0.9807 3186549 PK04_096047 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 4489120.0 -516000.0 -0.57 4064960.0 -523000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C04 compound treatment 2903280.0 -2579716.72131148 -2.85241946997978 -3.8349 -0.9789 3186726 PK04_096048 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 3387600.0 -1620000.0 -1.77 2576960.0 -2010000.0 -2.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C05 compound treatment 2441800.0 -3041196.72131148 -3.36268268071598 -4.9197 -0.9893 3186792 PK04_096049 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 2429760.0 -2580000.0 -2.82 2258320.0 -2330000.0 -2.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C06 compound treatment 5822640.0 339643.27868852 0.37554708738965 0.2258 0.6003 3186987 PK04_096050 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 5023520.0 18100.0 0.02 4583560.0 -4280.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C07 compound treatment 3104480.0 -2378516.72131148 -2.62995054824942 -3.5175 -0.9746 3068275 PK04_096051 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 3642640.0 -1360000.0 -1.49 2624680.0 -1960000.0 -1.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C08 compound treatment 4762720.0 -720276.72131148 -0.796417423149305 -0.7525 -0.8232 3186560 PK04_096052 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 4599960.0 -405000.0 -0.44 4525240.0 -62600.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C09 compound treatment 4057440.0 -1425556.72131148 -1.57625281637985 -2.623 -0.9918 3068147 PK04_096053 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 3437760.0 -1570000.0 -1.72 3342240.0 -1250000.0 -1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C10 compound treatment 5451280.0 -31716.7213114798 -0.0350695069134547 -0.4088 -0.829 3186976 PK04_096054 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4778600.0 -227000.0 -0.25 4164840.0 -423000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C11 mock treatment 4975520.0 -507476.72131148 -0.561122261398711 -0.8509 -0.8688 4280480.0 -725000.0 -0.79 4469440.0 -118000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C12 mock treatment 5107680.0 -375316.72131148 -0.414991581995711 -0.4201 -0.7418 4658960.0 -346000.0 -0.38 4654440.0 66600.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C13 compound treatment 5255480.0 -227516.72131148 -0.251567592772319 -0.3699 -0.9544 3186974 PK04_096055 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 4759400.0 -246000.0 -0.27 4468560.0 -119000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C14 compound treatment 5329200.0 -153796.72131148 -0.170054626023006 -0.436 -0.8973 3186876 PK04_096056 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 4615800.0 -390000.0 -0.43 4430040.0 -158000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C15 mock treatment 4887640.0 -595356.72131148 -0.658292086655489 -0.6802 -0.8994 4806360.0 -199000.0 -0.22 4287040.0 -301000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C16 mock treatment 5060880.0 -422116.72131148 -0.466738826215296 -0.7113 -0.9943 4677800.0 -328000.0 -0.36 4182840.0 -405000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C17 compound treatment 4664320.0 -818676.72131148 -0.905219321252024 -0.95 -0.8504 3186553 PK04_096057 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 4921240.0 -84200.0 -0.09 3942200.0 -646000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C18 compound treatment 5305160.0 -177836.72131148 -0.196635902754605 -0.2104 -0.8355 3186634 PK04_096058 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 4995520.0 -9910.0 -0.01 4431480.0 -156000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C19 compound treatment 5086560.0 -396436.72131148 -0.438344184515319 -0.663 -0.9452 3186638 PK04_096059 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 4822520.0 -183000.0 -0.2 4080000.0 -508000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C20 compound treatment 5080200.0 -402796.72131148 -0.445376502319519 -1.0301 -0.9371 3068219 PK04_096060 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 4612000.0 -393000.0 -0.43 3683200.0 -905000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C21 compound treatment 4489440.0 -993556.72131148 -1.09858594666059 -1.6519 -0.9935 3068151 PK04_096061 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 4243000.0 -762000.0 -0.83 3663560.0 -924000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C22 compound treatment 5117880.0 -365116.72131148 -0.403713336460673 -0.7945 -0.9956 3068158 PK04_096062 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 4540880.0 -465000.0 -0.51 4125920.0 -462000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C23 compound treatment 2617280.0 -2865716.72131148 -3.16865262909947 -4.5506 -0.9846 3186800 PK04_096063 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2553920.0 -2450000.0 -2.68 2566600.0 -2020000.0 -2.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 C24 compound treatment 4678440.0 -804556.72131148 -0.889606691158422 -1.4636 -0.9643 3068376 PK04_096064 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 3997080.0 -1010000.0 -1.1 4048560.0 -539000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D01 compound treatment 4648520.0 -834476.72131148 -0.922689544727867 -1.5099 -0.9655 3068407 PK04_096065 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 3972840.0 -1030000.0 -1.13 4028080.0 -560000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D02 compound treatment 4771200.0 -711796.72131148 -0.787040999410372 -1.4002 -0.9968 3187117 PK04_096066 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 4186920.0 -819000.0 -0.9 3848640.0 -739000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D03 compound treatment 4834680.0 -648316.72131148 -0.71685050660996 -0.4386 -0.5977 3187274 PK04_096067 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 5085360.0 79900.0 0.09 4457960.0 -130000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D04 compound treatment 3810200.0 -1672796.72131148 -1.84962864246639 -3.0538 -0.9993 3068858 PK04_096068 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C=C)c2cc1O 3455920.0 -1550000.0 -1.7 2851320.0 -1740000.0 -1.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D05 compound treatment 4719360.0 -763636.72131148 -0.844361023776682 -0.7268 -0.7993 3187075 PK04_096069 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4708120.0 -297000.0 -0.33 4499280.0 -88600.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D06 compound treatment 5753520.0 270523.27868852 0.299120388234569 0.3135 0.7705 3187118 PK04_096070 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 5255880.0 250000.0 0.27 4557640.0 -30200.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D07 compound treatment 5475480.0 -7516.72131147981 -0.00831131652640403 0.0237 0.631 3068634 PK04_096071 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 5020800.0 15400.0 0.02 4620280.0 32400.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D08 compound treatment 5708640.0 225643.27868852 0.249496107880403 -0.3049 -0.4332 3068859 PK04_096072 OCc1ccc(cc1)c2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2 4417040.0 -588000.0 -0.64 4455120.0 -133000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D09 compound treatment 2932560.0 -2550436.72131148 -2.82004427103214 -5.0443 -0.9975 3067975 PK04_096073 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 2086680.0 -2920000.0 -3.2 1876960.0 -2710000.0 -2.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D10 compound treatment 4478520.0 -1004476.72131148 -1.11066030364516 -0.7447 -0.6658 3068860 PK04_096074 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C)c2cc1O 4897880.0 -108000.0 -0.12 4526600.0 -61200.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D11 mock treatment 5673440.0 190443.27868852 0.210575103681056 0.1142 0.5374 4982200.0 -23200.0 -0.03 4600440.0 12600.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D12 mock treatment 5754560.0 271563.27868852 0.300270326995005 -0.0541 -0.1319 4808760.0 -197000.0 -0.22 4409800.0 -178000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D13 compound treatment 5158440.0 -324556.72131148 -0.358865724803699 -0.9842 -0.9639 3187429 PK04_096075 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 4332760.0 -673000.0 -0.74 3980920.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D14 compound treatment 5220200.0 -262796.72131148 -0.290577053799391 0.0601 0.1239 3187119 PK04_096076 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 5010840.0 5410.0 0.01 4975240.0 387000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D15 mock treatment 4482800.0 -1000196.72131148 -1.10592786336184 -0.75 -0.6557 5084200.0 78800.0 0.09 4309400.0 -278000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D16 mock treatment 5097000.0 -385996.72131148 -0.426800568497103 -0.2107 -0.4903 5048920.0 43500.0 0.05 4602040.0 14200.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D17 compound treatment 5687280.0 204283.27868852 0.225878134877618 0.0572 0.2343 3187348 PK04_096077 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 4933360.0 -72100.0 -0.08 4540080.0 -47800.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D18 compound treatment 4916440.0 -566556.72131148 -0.626447628674205 -0.779 -0.9284 3068861 PK04_096078 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C4CC4)c2cc1O 4530520.0 -475000.0 -0.52 4385800.0 -202000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D19 compound treatment 5863960.0 380963.27868852 0.421235038910019 -0.1336 -0.2137 3187354 PK04_096079 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 4720720.0 -285000.0 -0.31 4248280.0 -340000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D20 compound treatment 5917240.0 434243.27868852 0.480147286175393 0.1379 0.2424 3187120 PK04_096080 OCc1ccc(cc1)c2cc[n+](Cc3sc4ccccc4c3Cl)cc2 4731720.0 -274000.0 -0.3 4646120.0 58300.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D21 compound treatment 5557120.0 74123.2786885202 0.0819588761677618 -0.1768 -0.612 3187433 PK04_096081 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 4852440.0 -153000.0 -0.17 4367920.0 -220000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D22 compound treatment 5502080.0 19083.2786885202 0.0211005786924202 -0.4427 -0.7367 3068862 PK04_096082 COc1cc2CCN(C)C(C)c2cc1O 4500960.0 -504000.0 -0.55 4353240.0 -235000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D23 compound treatment 5239680.0 -243316.72131148 -0.269037816248162 -0.6504 -0.9677 3068462 PK04_096083 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 4683680.0 -322000.0 -0.35 4084480.0 -503000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 D24 compound treatment 4421640.0 -1061356.72131148 -1.1735531081582 -2.3912 -0.976 3187121 PK04_096084 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 3346920.0 -1660000.0 -1.82 3440120.0 -1150000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E01 mock treatment 4066920.0 -1416076.72131148 -1.56577068229434 -1.6036 -0.893 4579040.0 -426000.0 -0.47 3845720.0 -742000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E02 mock treatment 4769720.0 -713276.72131148 -0.788677450723299 -0.4111 -0.5065 4921520.0 -83900.0 -0.09 4755760.0 168000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E03 compound treatment 2772080.0 -2710916.72131148 -2.99748866745007 -4.4377 -0.9885 3186708 PK04_096085 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 2592000.0 -2410000.0 -2.64 2549240.0 -2040000.0 -2.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E04 compound treatment 3242800.0 -2240196.72131148 -2.47700869311154 -2.2796 -0.846 3186710 PK04_096086 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 4199760.0 -806000.0 -0.88 4000920.0 -587000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E05 compound treatment 5411520.0 -71476.7213114798 -0.0790325502931709 -0.4734 -0.8928 3186888 PK04_096087 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 4679960.0 -325000.0 -0.36 4204640.0 -383000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E06 compound treatment 5717320.0 234323.27868852 0.259093673688651 0.1966 0.4424 3186565 PK04_096088 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 4812520.0 -193000.0 -0.21 4879440.0 292000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E07 compound treatment 5923760.0 440763.27868852 0.487356517635045 0.3653 0.7133 3186983 PK04_096089 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 5148760.0 143000.0 0.16 4576320.0 -11500.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E08 compound treatment 6200560.0 717563.27868852 0.793417141566269 0.3059 0.3709 3067581 PK04_096090 CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 4803600.0 -202000.0 -0.22 4545440.0 -42400.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E09 mock treatment 5553040.0 70043.2786885202 0.0774475779537467 -0.0835 -0.2973 5045800.0 40400.0 0.04 4322560.0 -265000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E10 mock treatment 5466320.0 -16676.7213114798 -0.0184396233010067 -0.1306 -0.4562 4752280.0 -253000.0 -0.28 4657000.0 69200.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E11 compound treatment 3013400.0 -2469596.72131148 -2.73065864661523 -4.253 -0.9914 3186717 PK04_096091 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 2599800.0 -2410000.0 -2.63 2593720.0 -1990000.0 -2.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E12 compound treatment 5778840.0 295843.27868852 0.327116974209781 0.6445 0.9653 3068221 PK04_096092 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 5472520.0 467000.0 0.51 4864600.0 277000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E13 compound treatment 2523480.0 -2959516.72131148 -3.27236825960795 -5.1035 -0.9964 3068273 PK04_096093 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 2348320.0 -2660000.0 -2.91 1939960.0 -2650000.0 -2.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E14 compound treatment 5991640.0 508643.27868852 0.562412135960375 0.625 0.7585 3068377 PK04_096094 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4935040.0 -70400.0 -0.08 5182880.0 595000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E15 compound treatment 5726360.0 243363.27868852 0.269089295221665 0.6271 0.983 3068408 PK04_096095 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 5396200.0 391000.0 0.43 4975680.0 388000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E16 compound treatment 5967160.0 484163.27868852 0.535344346676284 0.8014 0.8766 3186635 PK04_096096 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 5116560.0 111000.0 0.12 5316280.0 728000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E17 mock treatment 5851640.0 368643.27868852 0.407612687440248 0.2477 0.5781 4930400.0 -75000.0 -0.08 4691080.0 103000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E18 mock treatment 5590880.0 107883.27868852 0.119287657468044 -0.3119 -0.6422 4662600.0 -343000.0 -0.38 4304720.0 -283000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E19 compound treatment 3200160.0 -2282836.72131148 -2.52415618228938 -3.8845 -0.9845 3186791 PK04_096097 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2697960.0 -2310000.0 -2.53 2916840.0 -1670000.0 -1.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E20 compound treatment 5711000.0 228003.27868852 0.252105584298314 0.1322 0.4711 3068233 PK04_096098 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 4916040.0 -89400.0 -0.1 4662320.0 74500.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E21 compound treatment 2428120.0 -3054876.72131148 -3.37780879825709 -5.4476 -0.9952 3186719 PK04_096099 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)Sc6ccc(C)cc6)cc1 1948200.0 -3060000.0 -3.35 1887880.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E22 compound treatment 2648280.0 -2834716.72131148 -3.13437560835572 -5.0538 -0.9944 3186789 PK04_096100 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2140120.0 -2870000.0 -3.14 2115440.0 -2470000.0 -2.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E23 compound treatment 2968560.0 -2514436.72131148 -2.78023869855554 -4.5876 -0.9988 3186803 PK04_096101 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 2547600.0 -2460000.0 -2.69 2122560.0 -2470000.0 -2.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 E24 compound treatment 4628920.0 -854076.72131148 -0.944361467520685 -1.4899 -0.9885 3186711 PK04_096102 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 4127000.0 -878000.0 -0.96 3916080.0 -672000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F01 mock treatment 4009640.0 -1473356.72131148 -1.629105770946 -1.8167 -0.9306 4362560.0 -643000.0 -0.7 3777240.0 -811000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F02 mock treatment 5057360.0 -425636.72131148 -0.470630926635231 -0.7585 -0.9982 4633760.0 -372000.0 -0.41 4153320.0 -435000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F03 compound treatment 5322560.0 -160436.72131148 -0.177396542724246 -0.1732 -0.8405 3068521 PK04_096103 CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 4911280.0 -94200.0 -0.1 4568360.0 -19500.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F04 compound treatment 5750560.0 267563.27868852 0.295847485608715 0.2931 0.8713 3187122 PK04_096104 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 5138800.0 133000.0 0.15 4653400.0 65600.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F05 compound treatment 4842840.0 -640156.72131148 -0.707827910181929 -0.7532 -0.9049 3068461 PK04_096105 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4808720.0 -197000.0 -0.22 4207840.0 -380000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F06 compound treatment 5406200.0 -76796.7213114798 -0.0849149293369358 -0.3967 -0.7171 3068863 PK04_096106 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5ccc(CN6CCCC6)cc5)c2cc1O 4951800.0 -53600.0 -0.06 4046360.0 -541000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F07 compound treatment 5785880.0 302883.27868852 0.33490117504965 0.0832 0.2039 3187077 PK04_096107 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 4795880.0 -210000.0 -0.23 4626320.0 38500.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F08 compound treatment 6067960.0 584963.27868852 0.646799949610776 0.1411 0.1976 3187123 PK04_096108 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CN5CCCC5)cc4 4888480.0 -117000.0 -0.13 4314560.0 -273000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F09 mock treatment 5336080.0 -146916.72131148 -0.162447338838588 -0.4939 -0.8999 4809240.0 -196000.0 -0.21 4111360.0 -476000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F10 mock treatment 6131560.0 648563.27868852 0.717123127652777 0.3636 0.4569 5184760.0 179000.0 0.2 4305160.0 -283000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F11 compound treatment 5956960.0 473963.27868852 0.524066101141246 0.3057 0.5359 3187438 PK04_096109 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 4862360.0 -143000.0 -0.16 4749440.0 162000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F12 compound treatment 4959000.0 -523996.72131148 -0.579388596324086 -1.2092 -0.923 3187124 PK04_096110 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OC)c3ccc(CO)cc3)c4cccs4 4001960.0 -1000000.0 -1.1 4173160.0 -415000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F13 compound treatment 5616200.0 133203.27868852 0.147284243443256 -0.2046 -0.3852 3068559 PK04_096111 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4CCCCC4 4539480.0 -466000.0 -0.51 4596440.0 8600.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F14 compound treatment 5884760.0 401763.27868852 0.444233814118723 0.6499 0.9181 3068864 PK04_096112 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2cccs2 5143840.0 138000.0 0.15 5115880.0 528000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F15 compound treatment 2808960.0 -2674036.72131148 -2.95671006986848 -4.1474 -0.9851 3186801 PK04_096113 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2932160.0 -2070000.0 -2.27 2638520.0 -1950000.0 -1.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F16 compound treatment 4021520.0 -1461476.72131148 -1.61596993202872 -2.0917 -0.972 3187125 PK04_096114 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 4137520.0 -868000.0 -0.95 3535200.0 -1050000.0 -1.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F17 mock treatment 5672280.0 189283.27868852 0.209292479679033 0.1444 0.6681 4994600.0 -10800.0 -0.01 4640360.0 52500.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F18 mock treatment 5759200.0 276203.27868852 0.3054008230031 0.0785 0.2297 4865920.0 -140000.0 -0.15 4571280.0 -16600.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F19 compound treatment 2261400.0 -3221596.72131148 -3.56215282723763 -5.4981 -0.9929 3186718 PK04_096115 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NC6CC6)cc1 1991400.0 -3010000.0 -3.3 1937240.0 -2650000.0 -2.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F20 compound treatment 4847800.0 -635196.72131148 -0.702343586862931 -0.9332 -0.9709 3068865 PK04_096116 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4cccs4 4515080.0 -490000.0 -0.54 4212240.0 -376000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F21 compound treatment 4581600.0 -901396.72131148 -0.996683681120488 -1.8157 -0.9882 3067569 PK04_096117 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 3847800.0 -1160000.0 -1.27 3710560.0 -877000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F22 compound treatment 5574640.0 91643.2786885202 0.101330921439709 0.0323 0.1323 3187126 PK04_096118 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C=C)c2cc1O 4842800.0 -163000.0 -0.18 4720080.0 132000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F23 compound treatment 5337840.0 -145156.72131148 -0.160501288628621 -0.5159 -0.946 3068643 PK04_096119 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 4635600.0 -370000.0 -0.41 4260920.0 -327000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 F24 compound treatment 4737320.0 -745676.72131148 -0.824502465952243 -0.7852 -0.8638 3187127 PK04_096120 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)c5cccs5 4796600.0 -209000.0 -0.23 4282120.0 -306000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G01 compound treatment 4450760.0 -1032236.72131148 -1.14135482286601 -1.4594 -0.9687 3186434 PK04_096121 CN(C)CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 4323400.0 -682000.0 -0.75 3950560.0 -637000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G02 compound treatment 5178640.0 -304356.72131148 -0.336530375802938 -0.1955 -0.4106 3067602 PK04_096122 CC(C)N1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 4787040.0 -218000.0 -0.24 4824080.0 236000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G03 mock treatment 5247920.0 -235076.72131148 -0.259926762992406 -0.1675 -0.5071 4860640.0 -145000.0 -0.16 4715680.0 128000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G04 mock treatment 5696120.0 213123.27868852 0.235652614341317 0.0364 0.0658 5240080.0 235000.0 0.26 4159840.0 -428000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G05 compound treatment 4337760.0 -1145236.72131148 -1.26630009202869 -2.1708 -0.9891 3068238 PK04_096123 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)Sc5ccc(C)cc5)cc1 3658040.0 -1350000.0 -1.48 3573400.0 -1010000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G06 compound treatment 2748240.0 -2734756.72131148 -3.02384880211235 -5.0343 -0.9958 3068315 PK04_096124 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 2121480.0 -2880000.0 -3.16 2059320.0 -2530000.0 -2.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G07 compound treatment 2534760.0 -2948236.72131148 -3.25989584689862 -5.2738 -0.9962 3186805 PK04_096125 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 2080000.0 -2930000.0 -3.2 1926440.0 -2660000.0 -2.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G08 compound treatment 5288440.0 -194556.72131148 -0.215123379749295 -2.4623 -0.8514 3186712 PK04_096126 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 3377680.0 -1630000.0 -1.78 2328760.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G09 compound treatment 6189400.0 706403.27868852 0.781077414098521 1.0371 0.9683 3068360 PK04_096127 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 5563880.0 558000.0 0.61 4990080.0 402000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G10 compound treatment 6097080.0 614083.27868852 0.678998234902963 0.3857 0.5628 3186431 PK04_096128 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N([C@@H]3c4ccc(CO)cc24)C5CCCCC5)c6ccc(cc6)[N+](=O)[O-])cc1 5060520.0 55100.0 0.06 4516840.0 -71000.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G11 compound treatment 4749360.0 -733636.72131148 -0.811189713379512 -2.5507 -0.9363 3186642 PK04_096129 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 3030280.0 -1980000.0 -2.16 3149200.0 -1440000.0 -1.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G12 compound treatment 5941600.0 458603.27868852 0.507082390217895 0.3728 0.7208 3068326 PK04_096130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 5051040.0 45600.0 0.05 4676160.0 88300.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G13 compound treatment 6473840.0 990843.27868852 1.09558566507756 0.669 0.6066 3186484 PK04_096131 CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 5111160.0 106000.0 0.12 4535400.0 -52400.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G14 compound treatment 5046440.0 -436556.72131148 -0.482705283619801 -0.8854 -0.8153 3068146 PK04_096132 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 4120360.0 -885000.0 -0.97 4506600.0 -81200.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G15 compound treatment 6185760.0 702763.27868852 0.777052628436998 0.2339 0.2363 3068195 PK04_096133 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C6CC6)C4=O)c7ccccc7C2=O 4477880.0 -528000.0 -0.58 4792960.0 205000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G16 compound treatment 2837640.0 -2645356.72131148 -2.92499829712879 -5.0508 -0.997 3068279 PK04_096134 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2092080.0 -2910000.0 -3.19 1964480.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G17 compound treatment 6024400.0 541403.27868852 0.598635206914085 0.8492 0.9785 3068328 PK04_096135 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 5325920.0 320000.0 0.35 5107320.0 519000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G18 compound treatment 2527880.0 -2955116.72131148 -3.26750313408303 -4.9596 -0.9929 3068311 PK04_096136 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2364440.0 -2640000.0 -2.89 2165920.0 -2420000.0 -2.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G19 mock treatment 4603000.0 -879996.72131148 -0.97302147970384 -0.3608 -0.3451 5353400.0 348000.0 0.38 4554960.0 -32900.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G20 mock treatment 5554520.0 71523.2786885202 0.0790840292666738 0.5579 0.8398 5278960.0 274000.0 0.3 5173440.0 586000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G21 compound treatment 2353560.0 -3129436.72131148 -3.46025056169753 -5.6253 -0.9989 3068284 PK04_096137 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 2109600.0 -2900000.0 -3.17 1487200.0 -3100000.0 -3.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G22 compound treatment 4456600.0 -1026396.72131148 -1.13489747444203 -1.3995 -0.9576 3186501 PK04_096138 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 4332400.0 -673000.0 -0.74 4037800.0 -550000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G23 compound treatment 5263160.0 -219836.72131148 -0.243075737310643 -0.9699 -0.9252 3186555 PK04_096139 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 4292640.0 -713000.0 -0.78 3933920.0 -654000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 G24 compound treatment 4490520.0 -992476.72131148 -1.0973917794863 -0.9841 -0.8275 3186877 PK04_096140 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 4831600.0 -174000.0 -0.19 4172520.0 -415000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H01 compound treatment 5399040.0 -83956.7213114798 -0.0928318154183937 -0.406 -0.9195 3186629 PK04_096141 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 4721880.0 -284000.0 -0.31 4289040.0 -299000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H02 compound treatment 5142800.0 -340196.72131148 -0.37615903462409 -0.5688 -0.9738 3068866 PK04_096142 OCc1ccc(cc1)c2cc[n+](Cc3cc4OCOc4cc3Br)cc2 4804320.0 -201000.0 -0.22 4200400.0 -387000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H03 mock treatment 5293240.0 -189756.72131148 -0.209815970085747 0.0011 0.0028 4924720.0 -80700.0 -0.09 4886800.0 299000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H04 mock treatment 5497800.0 14803.2786885202 0.0163681384090906 -0.1378 -0.5992 4980520.0 -24900.0 -0.03 4360920.0 -227000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H05 compound treatment 6074680.0 591683.27868852 0.654230323139742 -0.557 -0.3045 3186432 PK04_096143 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 3447760.0 -1560000.0 -1.71 4674440.0 86600.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H06 compound treatment 5738680.0 255683.27868852 0.282711646691436 0.4975 0.809 3068867 PK04_096144 OCc1ccc(cc1)c2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2 5503200.0 498000.0 0.55 4621600.0 33800.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H07 compound treatment 5288040.0 -194956.72131148 -0.215565663887924 -0.2114 -0.8204 3187128 PK04_096145 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3C4CC5CC(C4)CC3C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 4996520.0 -8910.0 -0.01 4447480.0 -140000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H08 compound treatment 6179640.0 696643.27868852 0.770285681115975 0.5108 0.6515 3068868 PK04_096146 COc1cc2CC[N+](=Cc2cc1O)Cc3sc4ccccc4c3Cl 4979400.0 -26000.0 -0.03 4730240.0 142000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H09 compound treatment 5713560.0 230563.27868852 0.254936202785539 0.2258 0.6884 3186637 PK04_096147 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 5185440.0 180000.0 0.2 4527080.0 -60800.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H10 compound treatment 2518240.0 -2964756.72131148 -3.27816218182399 -5.7919 -0.9912 3187129 PK04_096148 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C4CC4)c2cc1O 1424600.0 -3580000.0 -3.92 1765760.0 -2820000.0 -2.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H11 compound treatment 6249600.0 766603.27868852 0.847641176962176 0.5779 0.5998 3187130 PK04_096149 CC1(C)OB(OC1(C)C)/C=C\CC(OC(=O)c2ccncc2)c3ccccc3 4788000.0 -217000.0 -0.24 4977840.0 390000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H12 compound treatment 6255040.0 772043.27868852 0.85365624124753 1.0062 0.935 3187131 PK04_096150 C[n+]1ccc(cc1)c2ccc(CO)cc2 5292040.0 287000.0 0.31 5161080.0 573000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H13 compound treatment 2524720.0 -2958276.72131148 -3.2709971787782 -4.8228 -0.9887 3068898 PK04_096151 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)C)c2ccccc2)c1 2409720.0 -2600000.0 -2.84 2356120.0 -2230000.0 -2.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H14 compound treatment 5277000.0 -205996.72131148 -0.227772706114082 -0.3742 -0.5545 3187132 PK04_096152 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 4451120.0 -554000.0 -0.61 4773920.0 186000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H15 compound treatment 4987240.0 -495756.72131148 -0.548163336136884 -0.7665 -0.9444 3187133 PK04_096153 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)C)c1 4498840.0 -507000.0 -0.55 4364040.0 -224000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H16 compound treatment 5239080.0 -243916.72131148 -0.269701242456105 -0.7353 -0.7447 3187134 PK04_096154 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C2)c6cccs6 4139600.0 -866000.0 -0.95 4532440.0 -55400.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H17 compound treatment 4791000.0 -691996.72131148 -0.76514793454824 -0.9353 -0.9437 3068899 PK04_096155 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)c3ccncc3)c1 4729520.0 -276000.0 -0.3 4037120.0 -551000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H18 compound treatment 2639720.0 -2843276.72131148 -3.14384048892238 -4.0578 -0.972 3068900 PK04_096156 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C5CC5)c2cc1O 3244680.0 -1760000.0 -1.93 2638520.0 -1950000.0 -1.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H19 mock treatment 5569560.0 86563.2786885202 0.0957139128791218 0.311 0.8915 5130080.0 125000.0 0.14 4893200.0 305000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H20 mock treatment 6027400.0 544403.27868852 0.601952337953802 0.6872 0.7926 5574360.0 569000.0 0.62 4553280.0 -34600.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H21 compound treatment 1847000.0 -3635996.72131148 -4.02035919485721 -5.766 -0.9885 3187204 PK04_096157 CC(C)(C)OC(=O)COc1cccc(c1)C(=O)CCN2CCOCC2 2436360.0 -2570000.0 -2.81 1445960.0 -3140000.0 -3.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H22 compound treatment 5597480.0 114483.27868852 0.126585345755421 0.1744 0.9838 3187205 PK04_096158 OCCCc1cc[n+](Cc2cc3OCOc3cc2Br)cc1 5086160.0 80700.0 0.09 4674600.0 86800.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H23 compound treatment 5558160.0 75163.2786885202 0.0831088149281971 -0.2687 -0.5971 3068901 PK04_096159 COc1ccc(/C=C/C(=O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 4892240.0 -113000.0 -0.12 4164840.0 -423000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 H24 compound treatment 4560840.0 -922156.72131148 -1.01963822791533 -1.5274 -0.9939 3187206 PK04_096160 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 4258160.0 -747000.0 -0.82 3783160.0 -805000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I01 compound treatment 1881280.0 -3601716.72131148 -3.98245544417671 -5.9754 -0.9907 3186796 PK04_096161 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1774440.0 -3230000.0 -3.54 1769040.0 -2820000.0 -2.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I02 compound treatment 4739600.0 -743396.72131148 -0.821981446362058 -0.7992 -0.8636 3186628 PK04_096162 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 4651400.0 -354000.0 -0.39 4413880.0 -174000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I03 compound treatment 5134320.0 -348676.72131148 -0.385535458363024 -0.7454 -0.9537 3186882 PK04_096163 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 4444440.0 -561000.0 -0.61 4297720.0 -290000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I04 compound treatment 2467800.0 -3015196.72131148 -3.3339342117051 -4.8774 -0.9912 3186797 PK04_096164 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 2571000.0 -2430000.0 -2.67 2148680.0 -2440000.0 -2.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I05 mock treatment 4956600.0 -526396.72131148 -0.58204230115586 -0.5395 -0.846 4795480.0 -210000.0 -0.23 4465800.0 -122000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I06 mock treatment 5374400.0 -108596.72131148 -0.120076518357936 -0.606 -0.6406 5013360.0 7930.0 0.01 3652960.0 -935000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I07 compound treatment 5854400.0 371403.27868852 0.410664447996787 0.2062 0.4874 3186430 PK04_096165 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(C5CC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 5041960.0 36500.0 0.04 4494680.0 -93200.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I08 compound treatment 5692640.0 209643.27868852 0.231804742335245 -0.7074 -0.6696 3186557 PK04_096166 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 4322360.0 -683000.0 -0.75 3881400.0 -706000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I09 compound treatment 5915080.0 432083.27868852 0.477758951826797 -0.6937 -0.4064 3186558 PK04_096167 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 3509280.0 -1500000.0 -1.64 4547120.0 -40700.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I10 compound treatment 2522520.0 -2960476.72131148 -3.27342974154066 -5.2958 -0.9986 3068320 PK04_096168 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2258560.0 -2750000.0 -3.01 1707120.0 -2880000.0 -2.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I11 compound treatment 5913960.0 430963.27868852 0.476520556238636 0.702 0.9915 3068364 PK04_096169 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 5324240.0 319000.0 0.35 4976720.0 389000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I12 compound treatment 4388200.0 -1094796.72131148 -1.21052806214758 -2.191 -0.9821 3186489 PK04_096170 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 3557280.0 -1450000.0 -1.59 3592960.0 -995000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I13 compound treatment 5787640.0 304643.27868852 0.336847225259618 0.2985 0.7108 3186807 PK04_096171 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 5227080.0 222000.0 0.24 4525440.0 -62400.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I14 compound treatment 2442880.0 -3040116.72131148 -3.36148851354168 -5.1235 -0.994 3068281 PK04_096172 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2310640.0 -2690000.0 -2.95 2035480.0 -2550000.0 -2.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I15 compound treatment 5757560.0 274563.27868852 0.303587458034722 0.5962 0.9869 3186567 PK04_096173 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 5284280.0 279000.0 0.31 5009960.0 422000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I16 compound treatment 5819360.0 336363.27868852 0.371920357452892 0.4046 0.6901 3068410 PK04_096174 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 5406800.0 401000.0 0.44 4477560.0 -110000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I17 compound treatment 5634640.0 151643.27868852 0.16767354223405 0.5645 0.6786 3186973 PK04_096175 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 5001200.0 -4230.0 0.0 5399720.0 812000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I18 compound treatment 4828840.0 -654156.72131148 -0.723307855033942 -1.475 -0.9708 3068148 PK04_096176 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 3956880.0 -1050000.0 -1.15 3907120.0 -681000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I19 compound treatment 4611600.0 -871396.72131148 -0.963512370723318 -1.3267 -0.8996 3068239 PK04_096177 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 4010680.0 -995000.0 -1.09 4343680.0 -244000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I20 compound treatment 3410240.0 -2072756.72131148 -2.29186855268146 -3.9247 -0.9989 3068268 PK04_096178 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 3064000.0 -1940000.0 -2.13 2216600.0 -2370000.0 -2.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I21 mock treatment 5515000.0 32003.2786885202 0.0353863563701349 0.0681 0.3106 5177720.0 172000.0 0.19 4482160.0 -106000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I22 mock treatment 4519000.0 -963996.72131148 -1.06590114881592 -1.0166 -0.8394 4880840.0 -125000.0 -0.14 4031400.0 -556000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I23 compound treatment 5552520.0 69523.2786885202 0.0768726085735291 -0.1035 -0.4105 3186564 PK04_096179 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 4990280.0 -15200.0 -0.02 4349200.0 -239000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 I24 compound treatment 4860840.0 -622156.72131148 -0.687925123943627 -0.4977 -0.7103 3068366 PK04_096180 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 4959160.0 -46300.0 -0.05 4464800.0 -123000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J01 compound treatment 2312920.0 -3170076.72131148 -3.50518663018223 -5.3181 -0.9906 1230870 PK04_096181 Oc1cccc(c1)C(=O)CCN2CCOCC2 2075280.0 -2930000.0 -3.21 2099560.0 -2490000.0 -2.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J02 compound treatment 4629560.0 -853436.72131148 -0.943653812898878 -1.5694 -0.9796 3187207 PK04_096182 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)C3CC3 3989320.0 -1020000.0 -1.11 3928280.0 -660000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J03 compound treatment 4530640.0 -952356.72131148 -1.05303068038181 -1.5198 -0.9684 3068902 PK04_096183 COc1ccc(CC[C@H](O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 4073080.0 -932000.0 -1.02 4031480.0 -556000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J04 compound treatment 5045800.0 -437196.72131148 -0.483412938241607 -0.9232 -0.9973 3187208 PK04_096184 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 4476720.0 -529000.0 -0.58 4053160.0 -535000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J05 mock treatment 5400280.0 -82716.7213114798 -0.091460734588644 0.1478 0.5636 5159800.0 154000.0 0.17 4765680.0 178000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J06 mock treatment 5964560.0 481563.27868852 0.532469499775196 0.3237 0.5935 4943160.0 -62300.0 -0.07 4683920.0 96100.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J07 compound treatment 5862680.0 379683.27868852 0.419819729666406 0.4442 0.9017 3187209 PK04_096185 CCCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c5cccc(O)c5 5212320.0 207000.0 0.23 4710440.0 123000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J08 compound treatment 5002360.0 -480636.72131148 -0.53144499569671 -1.5218 -0.963 3068903 PK04_096186 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 4061600.0 -944000.0 -1.03 3520800.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J09 compound treatment 5773720.0 290723.27868852 0.321455737235331 0.4958 0.968 1032549 PK04_096187 CCOC(=O)C1CCCCN1 5328880.0 323000.0 0.35 4770280.0 182000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J10 compound treatment 6333040.0 850043.27868852 0.939901648280172 0.9905 0.8802 3187210 PK04_096188 COc1cc2CCN(C)C(C=C)c2cc1O 5174520.0 169000.0 0.19 5176200.0 588000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J11 compound treatment 5400520.0 -82476.7213114798 -0.0911953641054667 0.6465 0.7274 3187211 PK04_096189 CCOC(=O)[C@@H]1CCCCN1C(=O)C(=O)OC 5416200.0 411000.0 0.45 5346320.0 758000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J12 compound treatment 6244040.0 761043.27868852 0.841493427435234 0.7889 0.7838 3187212 PK04_096190 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4ccc(CN5CCCC5)cc4)c2cc1O 4981080.0 -24400.0 -0.03 5137400.0 550000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J13 compound treatment 5649400.0 166403.27868852 0.183993826949457 0.4947 0.8179 3068904 PK04_096191 [O-][N+](=O)c1cc(Br)ccc1C(=O)NCc2ccccc2 5102800.0 97400.0 0.11 5152040.0 564000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J14 compound treatment 5410760.0 -72236.7213114798 -0.0798728901565659 -0.1395 -0.2154 3068905 PK04_096192 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C=C)c2cc1O 5339880.0 334000.0 0.37 4061800.0 -526000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J15 compound treatment 5604920.0 121923.27868852 0.13481183073392 0.0985 0.6591 3187213 PK04_096193 CC(=O)Nc1cc(Br)ccc1C(=O)O 5060160.0 54700.0 0.06 4563840.0 -24000.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J16 compound treatment 5017280.0 -465716.72131148 -0.51494779732585 -0.8398 -0.9232 3187214 PK04_096194 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5cccs5)c2cc1O 4800920.0 -205000.0 -0.22 3874800.0 -713000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J17 compound treatment 5392800.0 -90196.7213114798 -0.0997314479810051 -0.2025 -0.922 3068906 PK04_096195 CC(=O)Nc1cc(Br)ccc1C(=O)NCc2ccccc2 4837640.0 -168000.0 -0.18 4520880.0 -67000.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J18 compound treatment 4345520.0 -1137476.72131148 -1.25771977973929 -2.3593 -0.9983 3187215 PK04_096196 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5cccs5)c2cc1O 3682040.0 -1320000.0 -1.45 3213400.0 -1370000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J19 compound treatment 5667720.0 184723.27868852 0.204250440498663 0.0671 0.2721 3068907 PK04_096197 Brc1ccc2c(=O)oc(nc2c1)c3ccccc3 4885320.0 -120000.0 -0.13 4631280.0 43400.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J20 compound treatment 1593040.0 -3889956.72131148 -4.30116539447272 -6.1591 -0.9838 3187216 PK04_096198 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4ccc(CN5CCCC5)cc4)c2cc1O 1678000.0 -3330000.0 -3.64 1874800.0 -2710000.0 -2.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J21 mock treatment 5632920.0 149923.27868852 0.165771720437945 0.2915 0.9835 5194840.0 189000.0 0.21 4719000.0 131000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J22 mock treatment 5594080.0 111083.27868852 0.122825930577076 0.0759 0.6154 5014600.0 9170.0 0.01 4586360.0 -1480.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J23 compound treatment 5422080.0 -60916.7213114798 -0.067356249033367 -0.2211 -0.4953 3068908 PK04_096199 Nc1cc(Br)ccc1C(=O)O 5107160.0 102000.0 0.11 4162400.0 -425000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 J24 compound treatment 4583280.0 -899716.72131148 -0.994826087738246 -1.2496 -0.96 3068910 PK04_096200 Oc1ccc2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2c1 4564720.0 -441000.0 -0.48 3903320.0 -685000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K01 compound treatment 4212840.0 -1270156.72131148 -1.4044254285225 -1.6012 -0.9387 3068198 PK04_096201 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(Cc6ccccc6)C4=O)c7ccccc7C2=O 4388200.0 -617000.0 -0.68 3897400.0 -690000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K02 compound treatment 4248280.0 -1234716.72131148 -1.36523905383998 -1.2776 -0.8295 3186870 PK04_096202 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCc5ccccc5)cc1 4867840.0 -138000.0 -0.15 3893320.0 -695000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K03 compound treatment 4374360.0 -1108636.72131148 -1.22583109334414 -1.6378 -0.8676 3068155 PK04_096203 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 3705760.0 -1300000.0 -1.42 4400880.0 -187000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K04 compound treatment 4936560.0 -546436.72131148 -0.60420073650117 -0.0232 -0.032 3186875 PK04_096204 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 5295160.0 290000.0 0.32 4833680.0 246000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K05 compound treatment 5250840.0 -232156.72131148 -0.256698088780415 -0.5225 -0.9381 3068359 PK04_096205 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 4590040.0 -415000.0 -0.45 4395080.0 -193000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K06 compound treatment 5347920.0 -135076.72131148 -0.149355728335172 -0.1021 -0.3399 3186626 PK04_096206 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(F)(F)F)C4=O)c6ccccc6C2=O 5160680.0 155000.0 0.17 4391040.0 -197000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K07 mock treatment 5460000.0 -22996.7213114798 -0.0254277126913439 -0.0133 -0.1195 5076720.0 71300.0 0.08 4512360.0 -75500.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K08 mock treatment 5271840.0 -211156.72131148 -0.233478171502395 0.0066 0.0204 5029440.0 24000.0 0.03 4805600.0 218000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K09 compound treatment 4972600.0 -510396.72131148 -0.564350935610703 -1.1516 -0.9795 3186869 PK04_096207 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)Sc5ccc(C)cc5)cc1 4483240.0 -522000.0 -0.57 3732520.0 -855000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K10 compound treatment 5530920.0 47923.2786885202 0.0529892650875665 0.6066 0.857 3068235 PK04_096208 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 5446720.0 441000.0 0.48 5100480.0 513000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K11 compound treatment 6095880.0 612883.27868852 0.677671382487076 0.8013 0.9181 3186487 PK04_096209 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(Cc7ccccc7)c2c1)c8ccc(cc8)[N+](=O)[O-] 5184840.0 179000.0 0.2 5099800.0 512000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K12 compound treatment 5373520.0 -109476.72131148 -0.12104954346292 -0.808 -0.8034 3068411 PK04_096210 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4148000.0 -857000.0 -0.94 4249520.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K13 compound treatment 5821680.0 338683.27868852 0.37448560545694 0.3089 0.4209 3068329 PK04_096211 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 4677880.0 -328000.0 -0.36 5105200.0 517000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K14 compound treatment 5970600.0 487603.27868852 0.539147990268493 0.512 0.8027 3067608 PK04_096212 COCCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 5011760.0 6330.0 0.01 4927320.0 339000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K15 mock treatment 5955880.0 472883.27868852 0.522871933966948 0.6306 0.9427 5336080.0 331000.0 0.36 4794400.0 207000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K16 mock treatment 6027640.0 544643.27868852 0.60221770843698 0.6692 0.9301 5262080.0 257000.0 0.28 4862720.0 275000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K17 compound treatment 5422160.0 -60836.7213114798 -0.0672677922056412 0.4422 0.7151 3186979 PK04_096213 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 5499040.0 494000.0 0.54 4879400.0 292000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K18 compound treatment 5668400.0 185403.27868852 0.205002323534332 0.3251 0.7033 3186636 PK04_096214 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 4957200.0 -48200.0 -0.05 4997360.0 410000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K19 compound treatment 2168480.0 -3314516.72131148 -3.66489543264113 -5.5366 -0.9916 3186793 PK04_096215 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 2017560.0 -2990000.0 -3.27 1944520.0 -2640000.0 -2.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K20 compound treatment 5674920.0 191923.27868852 0.212211554993984 -0.0662 -0.2061 3186637 PK04_096216 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 4811720.0 -194000.0 -0.21 4473480.0 -114000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K21 compound treatment 5355760.0 -127236.72131148 -0.140686959218045 -0.4335 -0.6521 3067613 PK04_096217 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N(CC4(CC5CC6CC(C5)C4)C6)[C@@H]3c7ccc(CO)cc27)c8ccc(cc8)[N+](=O)[O-])cc1 4413240.0 -592000.0 -0.65 4626120.0 38300.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K22 compound treatment 5357560.0 -125436.72131148 -0.138696680594214 -0.702 -0.6506 3186873 PK04_096218 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 4028360.0 -977000.0 -1.07 4580760.0 -7080.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K23 mock treatment 5656320.0 173323.27868852 0.191645342547738 -0.2164 -0.4806 4794960.0 -210000.0 -0.23 4253080.0 -335000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 K24 mock treatment 4729720.0 -753276.72131148 -0.832905864586193 -0.9673 -0.9332 4517080.0 -488000.0 -0.53 4281200.0 -307000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L01 compound treatment 4861440.0 -621556.72131148 -0.687261697735684 -0.8773 -0.791 3068940 PK04_096219 Cc1nc2cc(Br)ccc2c(=O)o1 4211400.0 -794000.0 -0.87 4625080.0 37200.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L02 compound treatment 2980480.0 -2502516.72131148 -2.76705863122439 -3.8885 -0.9852 3187217 PK04_096220 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5ccc(CN6CCCC6)cc5)c2cc1O 3052880.0 -1950000.0 -2.14 2764640.0 -1820000.0 -1.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L03 compound treatment 5126160.0 -356836.72131148 -0.394558054791054 -0.4133 -0.8924 3068941 PK04_096221 CC(C)c1nc2cc(Br)ccc2c(=O)o1 4803840.0 -202000.0 -0.22 4487640.0 -100000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L04 compound treatment 5305040.0 -177956.72131148 -0.196768587996194 -0.0966 -0.1949 3068942 PK04_096222 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C)c2cc1O 4725480.0 -280000.0 -0.31 4922720.0 335000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L05 compound treatment 5743760.0 260763.27868852 0.288328655252023 0.2955 0.7273 3187218 PK04_096223 Cc1nc2cc(Br)ccc2c(=O)n1Cc3cccc(O)c3 4953360.0 -52100.0 -0.06 4867320.0 279000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L06 compound treatment 5871240.0 388243.27868852 0.429284610233065 1.0596 0.9781 3068943 PK04_096224 COc1cc2CCN(C)C(c3cccs3)c2cc1O 5666000.0 661000.0 0.72 5267960.0 680000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L07 mock treatment 5943640.0 460643.27868852 0.509338039324903 0.8379 0.9889 5356640.0 351000.0 0.38 5143200.0 555000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L08 mock treatment 6116160.0 633163.27868852 0.700095188315563 1.0053 0.9706 5611000.0 606000.0 0.66 4964400.0 377000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L09 compound treatment 5318040.0 -164956.72131148 -0.182394353490753 -0.955 -0.8673 3187219 PK04_096225 Oc1cccc(CNC(=O)c2ccc(Br)cc2NC(=O)c3ccccc3)c1 4133320.0 -872000.0 -0.96 4073040.0 -515000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L10 compound treatment 4628400.0 -854596.72131148 -0.944936436900902 -0.9149 -0.8705 3187220 PK04_096226 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 4767640.0 -238000.0 -0.26 4209880.0 -378000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L11 compound treatment 5562600.0 79603.2786885202 0.0880181688669783 0.3266 0.544 3068944 PK04_096227 Oc1cccc(Cn2c(nc3cc(Br)ccc3c2=O)c4ccccc4)c1 4908120.0 -97300.0 -0.11 5170040.0 582000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L12 compound treatment 5753040.0 270043.27868852 0.298589647268215 0.4382 0.9918 3187221 PK04_096228 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 5221400.0 216000.0 0.24 4810920.0 223000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L13 compound treatment 5426360.0 -56636.7213114798 -0.0626238087500374 -0.0569 -0.3234 1980253 PK04_096229 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2)/C#N)c(=O)n(c3ccccc3)n1C 5093880.0 88400.0 0.1 4455600.0 -132000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L14 compound treatment 4376280.0 -1106716.72131148 -1.22370812947872 -1.8888 -0.972 3068945 PK04_096230 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3cccs3 3795160.0 -1210000.0 -1.33 3867960.0 -720000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L15 mock treatment 6158720.0 675723.27868852 0.747154220665682 0.5062 0.6486 5197400.0 192000.0 0.21 4507440.0 -80400.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L16 mock treatment 6051400.0 568403.27868852 0.628489386271538 0.6614 0.8656 5393120.0 388000.0 0.42 4679960.0 92100.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L17 compound treatment 3167040.0 -2315956.72131148 -2.56077730896786 -4.0429 -0.9975 3187222 PK04_096231 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 2930960.0 -2070000.0 -2.27 2425600.0 -2160000.0 -2.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L18 compound treatment 5681360.0 198363.27868852 0.219332329625909 -0.0897 -0.1883 3187223 PK04_096232 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6cccs6 5047280.0 41800.0 0.05 4168760.0 -419000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L19 compound treatment 4122080.0 -1360916.72131148 -1.50477969957741 -1.9316 -0.9679 3068946 PK04_096233 Cc1c(NC(=O)/C(=C/C=C/c2ccc(cc2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 4064320.0 -941000.0 -1.03 3780520.0 -807000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L20 compound treatment 4950320.0 -532676.72131148 -0.588986162132334 -0.7716 -0.9725 3187224 PK04_096234 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5cccs5 4700760.0 -305000.0 -0.33 4175440.0 -412000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L21 compound treatment 4596760.0 -886236.72131148 -0.979921112266451 -1.5527 -0.9977 3068947 PK04_096235 CN(C)c1ccc(/C=C/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)cc1 4211160.0 -794000.0 -0.87 3751280.0 -837000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L22 compound treatment 5548040.0 65043.2786885202 0.071919026220885 0.0778 0.8332 3187225 PK04_096236 COc1cc2CCN(C)C(C3CC3)c2cc1O 5008520.0 3090.0 0.0 4647040.0 59200.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L23 mock treatment 5179040.0 -303956.72131148 -0.336088091664309 -0.5467 -0.9922 4767800.0 -238000.0 -0.26 4238480.0 -349000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 L24 mock treatment 5092560.0 -390436.72131148 -0.431709922435885 -0.6659 -0.8751 4441120.0 -564000.0 -0.62 4484520.0 -103000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M01 compound treatment 5084360.0 -398636.72131148 -0.440776747277778 -0.7031 -0.9215 3186502 PK04_096237 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 4461280.0 -544000.0 -0.6 4407320.0 -181000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M02 compound treatment 3097240.0 -2385756.72131148 -2.63795589115861 -4.2227 -0.9963 3186497 PK04_096238 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC(C)C)c5ccccc5C2=O 2696800.0 -2310000.0 -2.53 2447720.0 -2140000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M03 compound treatment 4992160.0 -490836.72131148 -0.542723241231748 0.0984 0.1322 3068404 PK04_096239 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 5375320.0 370000.0 0.41 4894800.0 307000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M04 compound treatment 4952560.0 -530436.72131148 -0.586509370956012 -0.9962 -0.9984 3186643 PK04_096240 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NC5CC5)cc1 4520680.0 -485000.0 -0.53 3981840.0 -606000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M05 compound treatment 2582600.0 -2900396.72131148 -3.2069986639186 -4.9645 -0.9952 3186723 PK04_096241 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2382000.0 -2620000.0 -2.87 2078040.0 -2510000.0 -2.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M06 compound treatment 5597120.0 114123.27868852 0.126187290030655 0.7184 0.8956 3186868 PK04_096242 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NC5CC5)cc1 5547240.0 542000.0 0.59 5110760.0 523000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M07 compound treatment 2647560.0 -2835436.72131148 -3.13517171980526 -4.8058 -0.9951 3186798 PK04_096243 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2522920.0 -2480000.0 -2.72 2126600.0 -2460000.0 -2.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M08 compound treatment 2692120.0 -2790876.72131148 -3.08590126676199 -4.7999 -0.9921 3186799 PK04_096244 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 2316120.0 -2690000.0 -2.95 2313360.0 -2270000.0 -2.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M09 mock treatment 6450000.0 967003.27868852 1.06922553041527 1.1765 0.9266 5451120.0 446000.0 0.49 5066600.0 479000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M10 mock treatment 5968760.0 485763.27868852 0.5371134832308 1.0431 0.9713 5428480.0 423000.0 0.46 5391200.0 803000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M11 compound treatment 2941800.0 -2541196.72131148 -2.80982750742981 -2.8221 -0.8821 3186496 PK04_096245 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 3781600.0 -1220000.0 -1.34 3852440.0 -735000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M12 compound treatment 6682440.0 1199443.27868852 1.32623684337255 1.5574 0.9281 3068379 PK04_096246 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 5410600.0 405000.0 0.44 5512160.0 924000.0 0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M13 mock treatment 6076720.0 593723.27868852 0.65648597224675 0.6574 0.8543 5362480.0 357000.0 0.39 4678720.0 90900.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M14 mock treatment 6043360.0 560363.27868852 0.619599475085097 1.0644 0.9944 5491600.0 486000.0 0.53 5277000.0 689000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M15 compound treatment 5950120.0 467123.27868852 0.516503042370692 1.35 0.9679 3186488 PK04_096247 CC(C)N1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 5927000.0 922000.0 1.01 5397440.0 810000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M16 compound treatment 6286800.0 803803.27868852 0.888773601854667 0.7895 0.8301 3186886 PK04_096248 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 5220520.0 215000.0 0.24 4830080.0 242000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M17 compound treatment 6257600.0 774603.27868852 0.856486859734755 1.1582 0.9427 3068154 PK04_096249 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 5749440.0 744000.0 0.81 4921400.0 334000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M18 compound treatment 5973560.0 490563.27868852 0.542420892894347 0.3091 0.4661 3068369 PK04_096250 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCC(F)(F)F)cc1 4755880.0 -250000.0 -0.27 4853120.0 265000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M19 compound treatment 2395720.0 -3087276.72131148 -3.41363381348604 -4.7395 -0.9754 3186727 PK04_096251 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 2377360.0 -2630000.0 -2.88 2677280.0 -1910000.0 -1.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M20 compound treatment 5485560.0 2563.27868852019 0.00283424376704516 0.1315 0.8221 3186984 PK04_096252 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 5097320.0 91900.0 0.1 4711680.0 124000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M21 compound treatment 5296920.0 -186076.72131148 -0.205746956010361 0.3441 0.5676 3068372 PK04_096253 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 5331280.0 326000.0 0.36 5031240.0 443000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M22 compound treatment 2441520.0 -3041476.72131148 -3.36299227961302 -5.0086 -0.9922 3186721 PK04_096254 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCC(F)(F)F)cc1 2416120.0 -2590000.0 -2.84 2120040.0 -2470000.0 -2.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M23 compound treatment 2840320.0 -2642676.72131148 -2.92203499339997 -4.2079 -0.9846 3068316 PK04_096255 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 2726680.0 -2280000.0 -2.5 2723800.0 -1860000.0 -1.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 M24 compound treatment 2220600.0 -3262396.72131148 -3.60726580937778 -5.6369 -0.9945 3068283 PK04_096256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1930760.0 -3070000.0 -3.37 1808800.0 -2780000.0 -2.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N01 compound treatment 6405200.0 922203.27868852 1.01968970688883 0.311 0.2778 1694663 PK04_096257 Cc1c(NC(=O)CC#N)c(=O)n(c2ccccc2)n1C 4583520.0 -422000.0 -0.46 4569000.0 -18800.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N02 compound treatment 5110720.0 -372276.72131148 -0.411630222542131 -0.5123 -0.6292 3187226 PK04_096258 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C)C=C(CCCO)C=C1C(=O)OC 4390000.0 -615000.0 -0.67 4785400.0 198000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N03 compound treatment 5756160.0 273163.27868852 0.30203946354952 -0.3022 -0.2852 3068949 PK04_096259 Cc1ccccc1/C=C/C=O 4091840.0 -914000.0 -1.0 4762200.0 174000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N04 compound treatment 6225840.0 742843.27868852 0.821369499127617 2.1467 0.9674 3187227 PK04_096260 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2ccc(CN3CCCC3)cc2 6477720.0 1470000.0 1.61 5867680.0 1280000.0 1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N05 compound treatment 5586640.0 103643.27868852 0.114599445598577 1.2321 0.8374 3068950 PK04_096261 CCOc1ccc(cc1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 6144360.0 1140000.0 1.25 5357280.0 769000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N06 compound treatment 4912360.0 -570636.72131148 -0.63095892688822 0.1804 0.1932 3187228 PK04_096262 Oc1ccc2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2c1 5325680.0 320000.0 0.35 5178480.0 591000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N07 compound treatment 5519880.0 36883.2786885202 0.0407822228614079 0.7867 0.8365 3068951 PK04_096263 [O-][N+](=O)c1cccc(c1)C2SCC(=O)N2c3ccccc3 5546840.0 541000.0 0.59 5314080.0 726000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N08 compound treatment 5495400.0 12403.2786885202 0.013714433577317 1.1016 0.7329 3187299 PK04_096264 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4cccs4)C1=O 6310560.0 1310000.0 1.43 5051200.0 463000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N09 mock treatment 6343440.0 860443.27868852 0.951401035884525 0.9177 0.8523 5151640.0 146000.0 0.16 5064200.0 476000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N10 mock treatment 5958320.0 475323.27868852 0.525569867212585 0.9304 0.9999 5499200.0 494000.0 0.54 5131080.0 543000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N11 compound treatment 5809600.0 326603.27868852 0.361128624470346 0.8142 0.9444 3068985 PK04_096265 Cc1cc(C)cc(c1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 5322880.0 317000.0 0.35 5286880.0 699000.0 0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N12 compound treatment 6263440.0 780443.27868852 0.862944208158737 1.0464 0.9405 3187300 PK04_096266 COc1cc2CCN(C)C(c3ccc(CN4CCCC4)cc3)c2cc1O 5571920.0 566000.0 0.62 4915800.0 328000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N13 mock treatment 7183040.0 1700043.27868852 1.87975544286666 2.5944 0.9621 6565640.0 1560000.0 1.71 5489920.0 902000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N14 mock treatment 5887760.0 404763.27868852 0.447550945158441 0.8485 0.9633 5621160.0 616000.0 0.67 4934480.0 347000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N15 compound treatment 5532640.0 49643.2786885202 0.0548910868836709 0.7462 0.8133 3068986 PK04_096267 COc1ccc(/C=C/C=O)cc1 5744840.0 739000.0 0.81 5014080.0 426000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N16 compound treatment 5552080.0 69083.2786885202 0.0763860960210372 0.0218 0.1316 3187301 PK04_096268 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 4894560.0 -111000.0 -0.12 4670320.0 82500.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N17 compound treatment 5222880.0 -260116.72131148 -0.287613750070577 0.1465 0.2903 3068987 PK04_096269 Cc1cccc(/C=C/C=O)c1 5149680.0 144000.0 0.16 4969880.0 382000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N18 compound treatment 5845520.0 362523.27868852 0.400845740119225 0.7261 0.8634 3068988 PK04_096270 OCCCc1cc[n+](Cc2sc3ccccc3c2Cl)cc1 5670120.0 665000.0 0.73 4716200.0 128000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N19 compound treatment 4754800.0 -728196.72131148 -0.805174649094158 -0.2987 -0.3551 3068989 PK04_096271 Cc1ccc(/C=C/C=O)cc1 5050520.0 45100.0 0.05 4825400.0 238000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N20 compound treatment 3742800.0 -1740196.72131148 -1.92415351982537 -3.6281 -0.9919 3187302 PK04_096272 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 2746080.0 -2260000.0 -2.47 2708840.0 -1880000.0 -1.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N21 compound treatment 5383040.0 -99956.7213114798 -0.110523180963551 0.3564 0.1797 3068990 PK04_096273 COc1cccc(/C=C/C=O)c1 6572080.0 1570000.0 1.72 3603440.0 -984000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N22 compound treatment 5443520.0 -39476.7213114798 -0.043649819202856 -0.2385 -0.8997 3068991 PK04_096274 Oc1ccc2cc[n+](Cc3cc4OCOc4cc3Br)cc2c1 4829600.0 -176000.0 -0.19 4411600.0 -176000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N23 compound treatment 5021160.0 -461836.72131148 -0.51065764118115 0.2082 0.2492 3187303 PK04_096275 Clc1ccccc1/C=C/C=O 5248040.0 243000.0 0.27 5191200.0 603000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 N24 compound treatment 4443520.0 -1039476.72131148 -1.1493601657752 -0.5349 -0.4545 3187304 PK04_096276 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)C5CC5 4979480.0 -26000.0 -0.03 4838280.0 250000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O01 compound treatment 4396000.0 -1086996.72131148 -1.20190352144431 -1.5869 -0.9679 3186631 PK04_096277 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 4158360.0 -847000.0 -0.93 3970960.0 -617000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O02 compound treatment 4325560.0 -1157436.72131148 -1.27978975825687 -0.8834 -0.6838 3067615 PK04_096278 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c7ccc(cc7)[N+](=O)[O-] 4891000.0 -114000.0 -0.13 4463280.0 -125000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O03 compound treatment 3025080.0 -2457916.72131148 -2.71774394976727 -4.361 -0.9971 3186715 PK04_096279 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 2651960.0 -2350000.0 -2.58 2337520.0 -2250000.0 -2.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O04 compound treatment 5300560.0 -182436.72131148 -0.201722170348838 0.02 0.0636 3068363 PK04_096280 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 5000080.0 -5350.0 -0.01 4829280.0 241000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O05 compound treatment 2542240.0 -2940756.72131148 -3.25162513350626 -5.1268 -0.9955 3068310 PK04_096281 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 2222840.0 -2780000.0 -3.05 2016040.0 -2570000.0 -2.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O06 compound treatment 5490880.0 7883.27868852019 0.00871662281081001 0.5029 0.8104 3068196 PK04_096282 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCN6CCOCC6)C4=O)c7ccccc7C2=O 5324960.0 320000.0 0.35 5098440.0 511000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O07 compound treatment 2142840.0 -3340156.72131148 -3.69324584592725 -5.4288 -0.9916 3068277 PK04_096283 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 2276400.0 -2730000.0 -2.99 1876520.0 -2710000.0 -2.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O08 compound treatment 2509880.0 -2973116.72131148 -3.28740592032134 -4.9242 -0.9914 3186720 PK04_096284 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 2381920.0 -2620000.0 -2.87 2227800.0 -2360000.0 -2.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O09 compound treatment 5406640.0 -76356.7213114798 -0.0844284167844439 0.2266 0.5671 3186632 PK04_096285 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 5350360.0 345000.0 0.38 4686640.0 98800.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O10 compound treatment 5844200.0 361203.27868852 0.399386202461749 0.9133 0.8523 3068157 PK04_096286 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(C5CCCCC5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 5197880.0 192000.0 0.21 5556080.0 968000.0 0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O11 mock treatment 6137200.0 654203.27868852 0.723359334007445 1.0467 0.965 5345120.0 340000.0 0.37 5302920.0 715000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O12 mock treatment 6060480.0 577483.27868852 0.638529236218415 1.1268 0.9938 5685520.0 680000.0 0.74 5154240.0 566000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O13 compound treatment 5934000.0 451003.27868852 0.498678991583946 0.7708 0.9859 3186874 PK04_096287 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 5460240.0 455000.0 0.5 4925040.0 337000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O14 compound treatment 6173480.0 690483.27868852 0.76347450538109 0.891 0.9095 3068138 PK04_096288 COCCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 5187120.0 182000.0 0.2 5166600.0 579000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O15 compound treatment 5683280.0 200283.27868852 0.221455293491328 0.7152 0.9482 3186972 PK04_096289 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 5501400.0 496000.0 0.54 5060360.0 473000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O16 compound treatment 5691520.0 208523.27868852 0.230566346747084 0.3265 0.7308 3186981 PK04_096290 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4964280.0 -41200.0 -0.05 4966480.0 379000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O17 compound treatment 2151000.0 -3331996.72131148 -3.68422324949922 -5.6862 -0.9948 3186709 PK04_096291 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCc5ccccc5)cc1 1992880.0 -3010000.0 -3.3 1732680.0 -2860000.0 -2.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O18 compound treatment 3070680.0 -2412316.72131148 -2.66732355796357 -4.7645 -0.9919 3186725 PK04_096292 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 2067040.0 -2940000.0 -3.22 2229200.0 -2360000.0 -2.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O19 compound treatment 3670160.0 -1812836.72131148 -2.00447231940038 -3.7281 -0.9988 3068321 PK04_096293 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 3000840.0 -2000000.0 -2.2 2338320.0 -2250000.0 -2.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O20 compound treatment 5457440.0 -25556.7213114798 -0.0282583311785691 -0.0766 -0.8466 3068192 PK04_096294 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 4986160.0 -19300.0 -0.02 4504800.0 -83000.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O21 compound treatment 5320800.0 -162196.72131148 -0.179342592934214 -0.3282 -0.7876 3068201 PK04_096295 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 4662160.0 -343000.0 -0.38 4574680.0 -13200.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O22 compound treatment 5366640.0 -116356.72131148 -0.128656830647338 -0.2188 -0.7984 3068381 PK04_096296 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 4784640.0 -221000.0 -0.24 4579360.0 -8480.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O23 compound treatment 5236080.0 -246916.72131148 -0.273018373495822 -0.2308 -0.5339 3186880 PK04_096297 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCc6ccccc6)cc1 4738960.0 -266000.0 -0.29 4752280.0 164000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 O24 compound treatment 4599280.0 -883716.72131148 -0.977134722193089 -0.8903 -0.7243 3186977 PK04_096298 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 4341000.0 -664000.0 -0.73 4750040.0 162000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P01 compound treatment 4289960.0 -1193036.72131148 -1.31915304659485 -1.7119 -0.9677 3068992 PK04_096299 Cc1c(NC(=O)/C(=C/c2cccc(c2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 4133960.0 -871000.0 -0.95 3898680.0 -689000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P02 compound treatment 5030160.0 -452836.72131148 -0.500706248061999 -0.3371 -0.6476 3187305 PK04_096300 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)C2CC2 4883640.0 -122000.0 -0.13 4637800.0 50000.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P03 compound treatment 5266840.0 -216156.72131148 -0.239006723235257 -0.1668 -0.5962 3187306 PK04_096301 COc1cccc(/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)c1 5073800.0 68400.0 0.07 4463440.0 -124000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P04 compound treatment 4898680.0 -584316.72131148 -0.64608504442933 -0.2598 -0.3754 3068993 PK04_096302 COc1cc2CC[N+](=Cc2cc1O)C 4962240.0 -43200.0 -0.05 4830360.0 243000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P05 compound treatment 4564680.0 -918316.72131148 -1.01539230018449 -1.0622 -0.9038 3068994 PK04_096303 Cc1c(NC(=O)/C(=C/c2ccccc2Cl)/C#N)c(=O)n(c3ccccc3)n1C 4563080.0 -442000.0 -0.48 4249080.0 -339000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P06 compound treatment 4298840.0 -1184156.72131148 -1.30933433871728 -3.4664 -0.9611 3187307 PK04_096304 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4cccs4)c2cc1O 2523880.0 -2480000.0 -2.72 2617800.0 -1970000.0 -1.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P07 compound treatment 4950240.0 -532756.72131148 -0.58907461896006 -0.5498 -0.8362 3187308 PK04_096305 Cc1c(NC(=O)/C(=C/c2ccc(Cl)cc2)/C#N)c(=O)n(c3ccccc3)n1C 4929400.0 -76000.0 -0.08 4308960.0 -279000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P08 compound treatment 4948720.0 -534276.72131148 -0.59075529868685 -0.2295 -0.2705 3068995 PK04_096306 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3CCCO)C1=O 4710200.0 -295000.0 -0.32 5102480.0 515000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P09 compound treatment 4689480.0 -793516.72131148 -0.877399648932264 -0.6455 -0.6487 1972122 PK04_096307 Cc1cc(C)cc(c1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)CC2=O 4613160.0 -392000.0 -0.43 4776120.0 188000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P10 compound treatment 5006640.0 -476356.72131148 -0.52671255541338 -0.3608 -0.4226 3187309 PK04_096308 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)C4CC4 4528920.0 -477000.0 -0.52 5009880.0 422000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P11 mock treatment 5070000.0 -412996.72131148 -0.456654747854557 0.0392 0.0436 4805440.0 -200000.0 -0.22 5328760.0 741000.0 0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P12 mock treatment 5120120.0 -362876.72131148 -0.401236545284351 -0.1958 -0.4516 4931680.0 -73800.0 -0.08 4730240.0 142000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P13 compound treatment 4589240.0 -893756.72131148 -0.988236054072675 -1.0578 -0.8654 3068996 PK04_096309 Clc1ccc(/C=C/C=O)cc1 4360880.0 -645000.0 -0.71 4450320.0 -138000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P14 compound treatment 4774800.0 -708196.72131148 -0.783060442162712 -0.5866 -0.7326 3187310 PK04_096310 COc1cc2CC[N+](=Cc2cc1O)Cc3cccc(OC(F)(F)F)c3 4882160.0 -123000.0 -0.13 4490280.0 -97600.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P15 compound treatment 5201120.0 -281876.72131148 -0.311674007211991 0.0652 0.1505 3068997 PK04_096311 O=C/C=C/c1ccc2OCOc2c1 5186520.0 181000.0 0.2 4813320.0 225000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P16 compound treatment 4670040.0 -812956.72131148 -0.89889465806963 -0.8969 -0.8474 3187311 PK04_096312 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3ccc(CN4CCCC4)cc3 4504280.0 -501000.0 -0.55 4482400.0 -105000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P17 compound treatment 4158560.0 -1324436.72131148 -1.46444338613445 -2.3949 -0.9608 3068998 PK04_096313 O=C/C=C/c1ccc(cc1)c2ccccc2 3338640.0 -1670000.0 -1.83 3732640.0 -855000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P18 compound treatment 3970640.0 -1512356.72131148 -1.67222847446232 -2.2838 -0.9795 3187312 PK04_096314 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 3846080.0 -1160000.0 -1.27 3577640.0 -1010000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P19 compound treatment 4651640.0 -831356.72131148 -0.919239728446561 -0.9534 -0.8348 3187313 PK04_096315 O=C/C=C/c1ccc(\C=C\c2ccccc2)cc1 4388680.0 -617000.0 -0.68 4531400.0 -56400.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P20 compound treatment 4863680.0 -619316.72131148 -0.684784906559362 -0.6995 -0.8934 3187314 PK04_096316 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4cccs4)c2cc1O 4717400.0 -288000.0 -0.32 4377240.0 -211000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P21 compound treatment 4442800.0 -1040196.72131148 -1.15015627722473 -0.9076 -0.7628 3069028 PK04_096317 [O-][N+](=O)c1cccc(c1)C2N(C(=O)CS2(=O)=O)c3ccccc3 4771760.0 -234000.0 -0.26 4422440.0 -165000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P22 compound treatment 4711000.0 -771996.72131148 -0.853604762274027 -1.3758 -0.986 3187315 PK04_096318 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 4164480.0 -841000.0 -0.92 3981560.0 -606000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P23 compound treatment 3435800.0 -2047196.72131148 -2.26360659622308 -3.0308 -0.9696 3069029 PK04_096319 CCOc1ccc(cc1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 3361880.0 -1640000.0 -1.8 3406000.0 -1180000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2096 P24 compound treatment 4077040.0 -1405956.72131148 -1.55458089358703 -1.7833 -0.9075 3187316 PK04_096320 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)C3CC3 3970640.0 -1030000.0 -1.13 4188320.0 -400000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A01 compound treatment 4240880.0 -1373853.96825397 -1.51908454737788 -2.4627 -0.9746 2141518 PK04_097001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 4106840.0 -897000.0 -0.98 3575520.0 -1760000.0 -1.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A02 compound treatment 4209880.0 -1404853.96825397 -1.55336156812163 -2.5201 -0.9781 2141905 PK04_097002 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4057520.0 -946000.0 -1.04 3564440.0 -1770000.0 -1.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A03 compound treatment 4222520.0 -1392213.96825397 -1.53938538934095 -2.2037 -0.9581 2141091 PK04_097003 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 4332520.0 -671000.0 -0.73 3796480.0 -1540000.0 -1.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A04 compound treatment 5197040.0 -417693.96825397 -0.461848542399274 -0.5884 -0.5552 2141692 PK04_097004 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 5309920.0 307000.0 0.34 4444120.0 -890000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A05 compound treatment 5505640.0 -109093.96825397 -0.120626329447049 -0.8089 -0.7071 2141533 PK04_097005 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 4863520.0 -140000.0 -0.15 4210560.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A06 compound treatment 3579840.0 -2034893.96825397 -2.25000331487606 -3.3959 -0.9746 2141714 PK04_097006 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 3793520.0 -1210000.0 -1.32 3035160.0 -2300000.0 -2.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A07 compound treatment 5070840.0 -543893.96825397 -0.601389188136703 -1.2897 -0.8888 2141463 PK04_097007 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 4672360.0 -331000.0 -0.36 4068440.0 -1270000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A08 compound treatment 5612800.0 -1933.96825397015 -0.00213840870835723 -0.657 -0.5281 2141076 PK04_097008 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 5098240.0 94800.0 0.1 4098560.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A09 compound treatment 5250760.0 -363973.96825397 -0.402449782581407 -1.0645 -0.8833 2141109 PK04_097009 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 4669400.0 -334000.0 -0.37 4262240.0 -1070000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A10 compound treatment 4264400.0 -1350333.96825397 -1.4930782400265 -2.4716 -0.9842 2141546 PK04_097010 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 4012880.0 -991000.0 -1.08 3636880.0 -1700000.0 -1.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A11 compound treatment 5154320.0 -460413.96825397 -0.509084488404844 -1.0769 -0.819 2141079 PK04_097011 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 4863080.0 -140000.0 -0.15 4135640.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A12 compound treatment 5582760.0 -31973.9682539701 -0.0353539475193903 -0.5728 -0.5028 2141141 PK04_097012 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 5157920.0 155000.0 0.17 4211920.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A13 mock treatment 5127800.0 -486933.96825397 -0.538407926795942 -0.9978 -0.7016 5113920.0 111000.0 0.12 4027600.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A14 mock treatment 5656800.0 42066.0317460299 0.0465128465408257 -0.7917 -0.6784 4740600.0 -263000.0 -0.29 4207960.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A15 compound treatment 4439360.0 -1175373.96825397 -1.2996231577902 -2.8773 -0.9395 2141882 PK04_097013 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 3935280.0 -1070000.0 -1.17 2828480.0 -2510000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A16 compound treatment 4908960.0 -705773.96825397 -0.780381579039833 -1.0769 -0.8545 2141936 PK04_097014 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 4911800.0 -91600.0 -0.1 4352760.0 -981000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A17 compound treatment 3658440.0 -1956293.96825397 -2.16309448163548 -3.256 -0.9884 2141372 PK04_097015 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 3649720.0 -1350000.0 -1.48 3346960.0 -1990000.0 -1.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A18 compound treatment 5229040.0 -385693.96825397 -0.426465811308959 -0.9149 -0.8633 2141092 PK04_097016 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 4810520.0 -193000.0 -0.21 4390280.0 -944000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A19 compound treatment 5203000.0 -411733.96825397 -0.455258508733702 -0.6938 -0.9084 2141344 PK04_097017 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 4864200.0 -139000.0 -0.15 4742000.0 -592000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A20 compound treatment 5485600.0 -129133.96825397 -0.142784764792359 -0.9306 -0.6993 2141115 PK04_097018 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 4861840.0 -142000.0 -0.16 4024600.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A21 compound treatment 4104840.0 -1509893.96825397 -1.66950538292558 -2.9331 -0.9756 2141570 PK04_097019 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 3872200.0 -1130000.0 -1.24 3169600.0 -2160000.0 -2.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A22 compound treatment 4787040.0 -827693.96825397 -0.915189784493933 -1.7862 -0.9288 2141549 PK04_097020 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4459520.0 -544000.0 -0.6 3756600.0 -1580000.0 -1.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A23 compound treatment 2670080.0 -2944653.96825397 -3.25593435977372 -5.0906 -0.9963 2141876 PK04_097021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 2595600.0 -2410000.0 -2.64 2419800.0 -2910000.0 -2.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 A24 compound treatment 4165280.0 -1449453.96825397 -1.60267624957875 -2.0458 -0.9694 2141753 PK04_097022 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 4141800.0 -862000.0 -0.94 4340280.0 -994000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B01 compound treatment 4579080.0 -1035653.96825397 -1.14513330816712 -2.3265 -0.9832 2141940 PK04_097023 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 3917160.0 -1090000.0 -1.19 3645040.0 -1690000.0 -1.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B02 compound treatment 4014520.0 -1600213.96825397 -1.769373141428 -3.0545 -0.9688 2142685 PK04_097024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 3900280.0 -1100000.0 -1.21 3028960.0 -2300000.0 -2.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B03 compound treatment 5175320.0 -439413.96825397 -0.485864571126825 -0.8431 -0.8052 2141335 PK04_097025 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 4959480.0 -43900.0 -0.05 4410920.0 -923000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B04 compound treatment 5725720.0 110986.03174603 0.122718403626591 -0.0963 -0.1616 2143933 PK04_097026 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 5223760.0 220000.0 0.24 4804960.0 -529000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B05 compound treatment 5582920.0 -31813.9682539701 -0.0351770338639388 0.1166 0.1847 2141445 PK04_097027 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 5504080.0 501000.0 0.55 5023880.0 -310000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B06 compound treatment 5044880.0 -569853.96825397 -0.630093428733721 -0.7339 -0.8438 2144925 PK04_097028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 4964160.0 -39300.0 -0.04 4737880.0 -596000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B07 compound treatment 2175160.0 -3439573.96825397 -3.8031725244993 -5.1653 -0.9809 2141881 PK04_097029 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 2782040.0 -2220000.0 -2.43 2632720.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B08 compound treatment 5631360.0 16626.0317460299 0.0183835753240254 0.3531 0.4727 2144289 PK04_097030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 5673200.0 670000.0 0.73 5194120.0 -140000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B09 compound treatment 4710640.0 -904093.96825397 -0.99966605497206 -1.6679 -0.9108 2141150 PK04_097031 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 4628200.0 -375000.0 -0.41 3860840.0 -1470000.0 -1.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B10 compound treatment 4335880.0 -1278853.96825397 -1.41404206445351 -2.3336 -0.992 2144633 PK04_097032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 3987880.0 -1020000.0 -1.11 3823440.0 -1510000.0 -1.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B11 compound treatment 6028720.0 413986.03174603 0.457748638638011 0.2138 0.1995 2141161 PK04_097033 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 5588120.0 585000.0 0.64 4608720.0 -725000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B12 compound treatment 5607560.0 -7173.96825397015 -0.0079323309243963 -0.1823 -0.2369 2144765 PK04_097034 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 5339400.0 336000.0 0.37 4660440.0 -673000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B13 mock treatment 5837040.0 222306.03174603 0.245806079407024 0.1649 0.1645 5649000.0 646000.0 0.71 4669080.0 -665000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B14 mock treatment 5636080.0 21346.0317460299 0.0236025281598469 -0.082 -0.1004 5449480.0 446000.0 0.49 4682000.0 -652000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B15 compound treatment 5588520.0 -26213.9682539701 -0.0289850559231337 -0.0282 -0.0354 2141135 PK04_097035 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 5508840.0 505000.0 0.55 4762480.0 -571000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B16 compound treatment 5210000.0 -404733.96825397 -0.447518536307696 -0.5628 -0.9085 2144753 PK04_097036 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 4898840.0 -105000.0 -0.11 4922560.0 -411000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B17 compound treatment 5662160.0 47426.0317460299 0.0524394539984535 -0.4746 -0.4377 2141225 PK04_097037 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 5178200.0 175000.0 0.19 4271760.0 -1060000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B18 compound treatment 1470480.0 -4144253.96825397 -4.58234449152189 -6.9645 -0.9901 2144045 PK04_097038 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 2047520.0 -2960000.0 -3.24 1105480.0 -4230000.0 -4.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B19 compound treatment 5016440.0 -598293.96825397 -0.661539830990238 -0.942 -0.7555 2141420 PK04_097039 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 5079640.0 76200.0 0.08 4284000.0 -1050000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B20 compound treatment 6101320.0 486586.03174603 0.538023209799163 0.2925 0.4374 2144377 PK04_097040 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5245320.0 242000.0 0.26 5038680.0 -295000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B21 compound treatment 5407400.0 -207333.96825397 -0.229251313894316 -0.9056 -0.8279 2141808 PK04_097041 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 4712800.0 -291000.0 -0.32 4316400.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B22 compound treatment 5460880.0 -153853.96825397 -0.170117924559627 -0.3916 -0.5856 2143265 PK04_097042 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 5118560.0 115000.0 0.13 4701800.0 -632000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B23 compound treatment 4915840.0 -698893.96825397 -0.772774291855416 -1.3098 -0.9779 2141931 PK04_097043 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 4500760.0 -503000.0 -0.55 4391880.0 -942000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 B24 compound treatment 3001240.0 -2613493.96825397 -2.88976732140282 -4.2384 -0.9919 2142705 PK04_097044 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 2959720.0 -2040000.0 -2.24 3128520.0 -2210000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C01 compound treatment 4273560.0 -1341173.96825397 -1.4829499332519 -2.2183 -0.9613 2141223 PK04_097045 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 4304280.0 -699000.0 -0.77 3745920.0 -1590000.0 -1.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C02 compound treatment 5425480.0 -189253.96825397 -0.209260070828288 -0.0025 -0.004 2141108 PK04_097046 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 5459320.0 456000.0 0.5 5040600.0 -293000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C03 compound treatment 3290960.0 -2323773.96825397 -2.56942091979388 -3.9234 -0.9876 2141329 PK04_097047 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 3396320.0 -1610000.0 -1.76 2876480.0 -2460000.0 -2.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C04 compound treatment 6224920.0 610186.03174603 0.674689008635504 1.2696 0.8381 2141703 PK04_097048 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 6230960.0 1230000.0 1.34 5513200.0 179000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C05 compound treatment 6045240.0 430506.03174603 0.476014973563386 0.5932 0.7949 2065845 PK04_097049 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 5527840.0 524000.0 0.57 5311040.0 -22800.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C06 compound treatment 6147520.0 532786.03174603 0.589107027810805 0.7833 0.8229 2141782 PK04_097050 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 5685960.0 683000.0 0.75 5353960.0 20100.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C07 compound treatment 5585440.0 -29293.9682539701 -0.0323906437905765 0.145 0.3667 2141574 PK04_097051 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 5352040.0 349000.0 0.38 5236000.0 -97900.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C08 compound treatment 4808880.0 -805853.96825397 -0.891041070524793 -1.4024 -0.9669 2141856 PK04_097052 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4531400.0 -472000.0 -0.52 4316360.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C09 compound treatment 4775840.0 -838893.96825397 -0.927573740375543 -1.7318 -0.9616 2141751 PK04_097053 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 4371360.0 -632000.0 -0.69 3958920.0 -1370000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C10 compound treatment 5917600.0 302866.03174603 0.334882104926892 0.8327 0.6254 2141441 PK04_097054 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 6169840.0 1170000.0 1.28 5164520.0 -169000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C11 mock treatment 5880040.0 265306.03174603 0.293351624309635 0.2951 0.6512 5302560.0 299000.0 0.33 5224480.0 -109000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C12 mock treatment 6027520.0 412786.03174603 0.456421786222124 0.7775 0.8444 5728240.0 725000.0 0.79 5429920.0 96100.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C13 compound treatment 5308920.0 -305813.96825397 -0.33814166882476 -0.0048 -0.0042 2141937 PK04_097055 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 5845440.0 842000.0 0.92 4743720.0 -590000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C14 compound treatment 210520.0 -5404213.96825397 -5.97549529978918 -8.9529 -0.9939 2141727 PK04_097056 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 729760.0 -4270000.0 -4.68 499960.0 -4830000.0 -4.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C15 mock treatment 5801960.0 187226.03174603 0.207017760449267 0.2974 0.4363 5539160.0 536000.0 0.59 5056280.0 -278000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C16 mock treatment 5450240.0 -164493.96825397 -0.181882682647157 -0.1675 -0.3536 5232120.0 229000.0 0.25 4976400.0 -357000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C17 compound treatment 6036840.0 422106.03174603 0.466727006652178 0.1648 0.1802 2141078 PK04_097057 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 5421880.0 418000.0 0.46 4696600.0 -637000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C18 compound treatment 5977000.0 362266.03174603 0.400561299513289 -0.0309 -0.0531 2141467 PK04_097058 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 4617800.0 -386000.0 -0.42 5302120.0 -31700.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C19 compound treatment 5567480.0 -47253.9682539701 -0.0522492016150157 -0.2327 -0.3518 2141339 PK04_097059 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 5237760.0 234000.0 0.26 4728600.0 -605000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C20 compound treatment 519680.0 -5095053.96825397 -5.63365388904288 -8.9412 -0.9979 2141364 PK04_097060 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 459280.0 -4540000.0 -4.98 474600.0 -4860000.0 -4.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C21 compound treatment 2603160.0 -3011573.96825397 -3.32992849616634 -5.6054 -0.9993 2141370 PK04_097061 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 2209080.0 -2790000.0 -3.06 2026880.0 -3310000.0 -3.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C22 compound treatment 5461520.0 -153213.96825397 -0.169410269937821 -0.6238 -0.7554 2141489 PK04_097062 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 4902640.0 -101000.0 -0.11 4536040.0 -798000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C23 compound treatment 5101080.0 -513653.96825397 -0.567952507256355 -0.7431 -0.97 2141706 PK04_097063 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4724040.0 -279000.0 -0.31 4922120.0 -412000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 C24 compound treatment 5179960.0 -434773.96825397 -0.480734075118729 -1.1109 -0.9783 2141172 PK04_097064 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 4427880.0 -576000.0 -0.63 4523600.0 -810000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D01 compound treatment 5350000.0 -264733.96825397 -0.292719087787568 -0.66 -0.6869 2141788 PK04_097065 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 5060600.0 57200.0 0.06 4424040.0 -910000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D02 compound treatment 5034800.0 -579933.96825397 -0.64123898902717 -0.7131 -0.9197 2143973 PK04_097066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 4807480.0 -196000.0 -0.21 4955960.0 -378000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D03 compound treatment 5885960.0 271226.03174603 0.299897429561343 -0.047 -0.0842 2141854 PK04_097067 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 5078840.0 75400.0 0.08 4871520.0 -462000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D04 compound treatment 5286200.0 -328533.96825397 -0.363263407898884 -0.5784 -0.8491 2141969 PK04_097068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 4943000.0 -60400.0 -0.07 4763440.0 -570000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D05 compound treatment 6105480.0 490746.03174603 0.542622964840903 0.946 0.791 2141087 PK04_097069 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 5976200.0 973000.0 1.07 5364280.0 30400.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D06 compound treatment 5003640.0 -611093.96825397 -0.675692923426364 -0.9948 -0.9869 2144657 PK04_097070 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 4592800.0 -411000.0 -0.45 4738320.0 -596000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D07 compound treatment 5701160.0 86426.0317460299 0.0955621575147748 0.0187 0.0304 2141768 PK04_097071 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 5365040.0 362000.0 0.4 4876240.0 -458000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D08 compound treatment 2627760.0 -2986973.96825397 -3.30272802164066 -5.2055 -0.9975 2144733 PK04_097072 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 2444040.0 -2560000.0 -2.8 2433600.0 -2900000.0 -2.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D09 compound treatment 5885080.0 270346.03174603 0.29892440445636 0.4287 0.8628 2141552 PK04_097073 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 5362920.0 360000.0 0.39 5383560.0 49700.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D10 compound treatment 3071160.0 -2543573.96825397 -2.81245605397048 -4.3809 -0.9944 2143885 PK04_097074 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 3024400.0 -1980000.0 -2.17 2734920.0 -2600000.0 -2.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D11 mock treatment 6494880.0 880146.03174603 0.973186573796173 0.6935 0.6293 5424480.0 421000.0 0.46 5101480.0 -232000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D12 mock treatment 6091400.0 476666.03174603 0.527054563161165 0.7036 0.8149 5627800.0 624000.0 0.68 5341640.0 7790.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D13 compound treatment 6363600.0 748866.03174603 0.828028919498156 0.957 0.5808 2141513 PK04_097075 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 6220320.0 1220000.0 1.33 4832480.0 -501000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D14 compound treatment 6059240.0 444506.03174603 0.491494918415398 0.8008 0.7894 2144449 PK04_097076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 5813840.0 810000.0 0.89 5341920.0 8070.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D15 mock treatment 5888520.0 273786.03174603 0.302728048048568 0.0965 0.1984 5179520.0 176000.0 0.19 5006640.0 -327000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D16 mock treatment 5599160.0 -15573.9682539701 -0.017220297835604 0.3347 0.4922 5619960.0 617000.0 0.68 5255840.0 -78000.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D17 compound treatment 6147880.0 533146.03174603 0.589505083535571 1.1765 0.8503 2141816 PK04_097077 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 6129400.0 1130000.0 1.23 5548320.0 214000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D18 compound treatment 4243440.0 -1371293.96825397 -1.51625392889066 -2.1477 -0.9582 2142085 PK04_097078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 4348840.0 -655000.0 -0.72 3852320.0 -1480000.0 -1.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D19 compound treatment 6361400.0 746666.03174603 0.825596356735697 0.6508 0.7201 2141432 PK04_097079 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 5334680.0 331000.0 0.36 5273000.0 -60900.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D20 compound treatment 5362720.0 -252013.96825397 -0.278654452179168 -0.5612 -0.9642 2144825 PK04_097080 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 4779840.0 -224000.0 -0.24 4886960.0 -447000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D21 compound treatment 5218160.0 -396573.96825397 -0.438495939879666 -0.0415 -0.0641 2141123 PK04_097081 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 5428000.0 425000.0 0.46 5235920.0 -97900.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D22 compound treatment 2893600.0 -2721133.96825397 -3.00878598310787 -4.1048 -0.9747 2144893 PK04_097082 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 3468560.0 -1530000.0 -1.68 2922440.0 -2410000.0 -2.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D23 compound treatment 4835880.0 -778853.96825397 -0.86118689116734 -1.4068 -0.9506 2141421 PK04_097083 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 4578320.0 -425000.0 -0.47 4227840.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 D24 compound treatment 5076080.0 -538653.96825397 -0.595595265920664 -1.9746 -0.864 2143085 PK04_097084 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 3108200.0 -1900000.0 -2.08 4587440.0 -746000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E01 mock treatment 5482160.0 -132573.96825397 -0.146588408384568 -0.6272 -0.8798 4711560.0 -292000.0 -0.32 4715920.0 -618000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E02 mock treatment 5386760.0 -227973.96825397 -0.252073175447569 -0.113 -0.1988 5357280.0 354000.0 0.39 5003800.0 -330000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E03 compound treatment 3075760.0 -2538973.96825397 -2.80736978637625 -4.2229 -0.9934 2141878 PK04_097085 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 3065160.0 -1940000.0 -2.12 2958040.0 -2380000.0 -2.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E04 compound treatment 5895320.0 280586.03174603 0.31024687840526 0.3771 0.737 2141520 PK04_097086 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 5370920.0 368000.0 0.4 5274480.0 -59400.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E05 compound treatment 645000.0 -4969733.96825397 -5.49508626841043 -8.7368 -0.998 2141359 PK04_097087 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 614280.0 -4390000.0 -4.81 520160.0 -4810000.0 -4.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E06 compound treatment 3234320.0 -2380413.96825397 -2.63204835382374 -3.7209 -0.9873 2141507 PK04_097088 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 3204440.0 -1800000.0 -1.97 3497840.0 -1840000.0 -1.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E07 compound treatment 5808680.0 193946.03174603 0.214448133978233 0.4795 0.798 2141863 PK04_097089 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 5513240.0 510000.0 0.56 5391440.0 57600.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E08 compound treatment 6576680.0 961946.03174603 1.06363368014579 -0.2621 -0.1497 2141163 PK04_097090 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 3739000.0 -1260000.0 -1.38 5201480.0 -132000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E09 mock treatment 6602840.0 988106.03174603 1.09255906281212 1.1045 0.8888 5454440.0 451000.0 0.49 5659240.0 325000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E10 mock treatment 6140360.0 525626.03174603 0.581190141729347 0.954 0.8911 5805280.0 802000.0 0.88 5526280.0 192000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E11 compound treatment 6295760.0 681026.03174603 0.753017529586688 1.015 0.9349 2141456 PK04_097091 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 5673040.0 670000.0 0.73 5604520.0 271000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E12 compound treatment 939040.0 -4675693.96825397 -5.1699631981043 -8.7741 -0.9998 2141683 PK04_097092 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 514840.0 -4490000.0 -4.92 240320.0 -5090000.0 -5.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E13 compound treatment 6158200.0 543466.03174603 0.600916014312197 0.3322 0.5316 2141357 PK04_097093 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 5101640.0 98200.0 0.11 5201200.0 -133000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E14 compound treatment 3087400.0 -2527333.96825397 -2.79449931794215 -4.6899 -0.9944 2141366 PK04_097094 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 2886320.0 -2120000.0 -2.32 2334480.0 -3000000.0 -3.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E15 compound treatment 6097760.0 483026.03174603 0.534086880965365 -0.2292 -0.2528 2141575 PK04_097095 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 4786360.0 -217000.0 -0.24 4642880.0 -691000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E16 compound treatment 6040600.0 425866.03174603 0.47088447755529 0.6021 0.7392 2141485 PK04_097096 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 5605040.0 602000.0 0.66 5247280.0 -86600.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E17 mock treatment 5766120.0 151386.03174603 0.167389101628114 0.1791 0.87 5110160.0 107000.0 0.12 5359600.0 25700.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E18 mock treatment 5673560.0 58826.0317460299 0.0650445519493782 0.2407 0.4051 5510040.0 507000.0 0.55 5131680.0 -202000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E19 compound treatment 4627200.0 -987533.96825397 -1.09192652629006 -1.4958 -0.983 2141377 PK04_097097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 4321000.0 -682000.0 -0.75 4585000.0 -749000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E20 compound treatment 2555400.0 -3059333.96825397 -3.38273722231863 -5.4361 -0.9976 2141326 PK04_097098 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 2398160.0 -2610000.0 -2.85 2165400.0 -3170000.0 -3.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E21 compound treatment 3651040.0 -1963693.96825397 -2.17127673820011 -3.6062 -0.9994 2141702 PK04_097099 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3188000.0 -1820000.0 -1.99 3254560.0 -2080000.0 -2.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E22 compound treatment 3577520.0 -2037213.96825397 -2.25256856288011 -3.4297 -0.9871 2141417 PK04_097100 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 3606960.0 -1400000.0 -1.53 3182920.0 -2150000.0 -2.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E23 compound treatment 5974760.0 360026.03174603 0.398084508336967 0.1277 0.3055 2141167 PK04_097101 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 4938440.0 -65000.0 -0.07 5228480.0 -105000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 E24 compound treatment 4521400.0 -1093333.96825397 -1.20891068095741 -1.8891 -0.9963 2141113 PK04_097102 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4013240.0 -990000.0 -1.08 4358520.0 -975000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F01 mock treatment 4935160.0 -679573.96825397 -0.751411967959638 -0.9949 -0.9739 4613120.0 -390000.0 -0.43 4791400.0 -542000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F02 mock treatment 5816200.0 201466.03174603 0.222763075784457 0.2973 0.6573 5353080.0 350000.0 0.38 5243360.0 -90500.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F03 compound treatment 3438160.0 -2176573.96825397 -2.40666035677843 -3.4461 -0.9845 2141216 PK04_097103 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 3597360.0 -1410000.0 -1.54 3318640.0 -2020000.0 -2.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F04 compound treatment 5598320.0 -16413.9682539701 -0.0181490945267247 -0.3529 -0.5882 2142933 PK04_097104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5009400.0 5980.0 0.01 4736280.0 -598000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F05 compound treatment 4800000.0 -814733.96825397 -0.900859778402356 -0.8859 -0.816 2141355 PK04_097105 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4977600.0 -25800.0 -0.03 4730680.0 -603000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F06 compound treatment 4479320.0 -1135413.96825397 -1.25543897234117 -2.908 -0.9705 2142833 PK04_097106 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 2951840.0 -2050000.0 -2.25 3804720.0 -1530000.0 -1.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F07 compound treatment 3621600.0 -1993133.96825397 -2.2038288508032 -1.9267 -0.8138 2141414 PK04_097107 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 4696320.0 -307000.0 -0.34 4539640.0 -794000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F08 compound treatment 6357720.0 742986.03174603 0.821527342660311 0.9297 0.9326 2144249 PK04_097108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 5420560.0 417000.0 0.46 5664560.0 331000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F09 mock treatment 6391000.0 776266.03174603 0.858325382994238 0.7272 0.8033 5154720.0 151000.0 0.17 5568600.0 235000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F10 mock treatment 6488560.0 873826.03174603 0.966198484405836 1.2223 0.9653 5585000.0 582000.0 0.64 5845960.0 512000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F11 compound treatment 3188480.0 -2426253.96825397 -2.68273411611061 -3.968 -0.9899 2141568 PK04_097109 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3287320.0 -1720000.0 -1.88 3031400.0 -2300000.0 -2.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F12 compound treatment 872120.0 -4742613.96825397 -5.24395733449692 -8.2006 -0.9953 2142765 PK04_097110 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1232040.0 -3770000.0 -4.13 521280.0 -4810000.0 -4.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F13 compound treatment 4388160.0 -1226573.96825397 -1.35623552753471 -1.8518 -0.9323 2141348 PK04_097111 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 4562560.0 -441000.0 -0.48 3970320.0 -1360000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F14 compound treatment 6320320.0 705586.03174603 0.780173775698505 0.7815 0.8549 2142645 PK04_097112 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 5426880.0 423000.0 0.46 5443160.0 109000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F15 compound treatment 5470320.0 -144413.96825397 -0.159680018887984 -0.5968 -0.877 2141505 PK04_097113 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 4756680.0 -247000.0 -0.27 4732200.0 -602000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F16 compound treatment 5993240.0 378506.03174603 0.418518035541624 0.7846 0.9968 2142977 PK04_097114 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 5463160.0 460000.0 0.5 5769320.0 435000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F17 mock treatment 6126480.0 511746.03174603 0.565842882118923 0.6821 0.9382 5195760.0 192000.0 0.21 5737320.0 403000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F18 mock treatment 6298480.0 683746.03174603 0.756025061729365 0.479 0.6276 5095920.0 92500.0 0.1 5306320.0 -27500.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F19 compound treatment 5399640.0 -215093.96825397 -0.237831626183717 -0.4994 -0.9905 2141200 PK04_097115 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 4696720.0 -307000.0 -0.34 5043520.0 -290000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F20 compound treatment 5000720.0 -614013.96825397 -0.678921597638355 -1.0724 -0.9326 2142045 PK04_097116 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 4729040.0 -274000.0 -0.3 4458920.0 -875000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F21 compound treatment 4685040.0 -929693.96825397 -1.02797223984431 -1.5336 -0.9861 2141938 PK04_097117 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4383200.0 -620000.0 -0.68 4388080.0 -946000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F22 compound treatment 6066760.0 452026.03174603 0.499809860221622 -0.0434 -0.0628 2144373 PK04_097118 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 4579160.0 -424000.0 -0.46 5223840.0 -110000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F23 compound treatment 3772800.0 -1841933.96825397 -2.03664544640146 -3.0471 -0.9924 2141419 PK04_097119 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 3418640.0 -1580000.0 -1.74 3833680.0 -1500000.0 -1.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 F24 compound treatment 4111560.0 -1503173.96825397 -1.66207500939662 -2.4919 -0.9867 2142769 PK04_097120 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 3593960.0 -1410000.0 -1.54 4227240.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G01 compound treatment 5283600.0 -331133.96825397 -0.366138254799972 -0.9048 -0.9563 2141178 PK04_097121 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4584040.0 -419000.0 -0.46 4594680.0 -739000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G02 compound treatment 4531640.0 -1083093.96825397 -1.19758820700851 -1.2966 -0.8948 2141487 PK04_097122 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 4744760.0 -259000.0 -0.28 4571600.0 -762000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G03 mock treatment 5819840.0 205106.03174603 0.22678786144598 0.5096 0.7393 5597760.0 594000.0 0.65 5338800.0 4950.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G04 mock treatment 6041920.0 427186.03174603 0.472344015212766 0.5812 0.9324 5344640.0 341000.0 0.37 5494000.0 160000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G05 compound treatment 5872240.0 257506.03174603 0.284727083606371 0.3989 0.8043 2141519 PK04_097123 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 5374200.0 371000.0 0.41 5333960.0 109.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G06 compound treatment 5423400.0 -191333.96825397 -0.211559948349159 -0.0427 -0.1169 2141537 PK04_097124 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 5248280.0 245000.0 0.27 5203680.0 -130000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G07 compound treatment 2955520.0 -2659213.96825397 -2.94032039844811 -4.5226 -0.9942 2141722 PK04_097125 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 2950600.0 -2050000.0 -2.25 2698240.0 -2640000.0 -2.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G08 compound treatment 6271680.0 656946.03174603 0.726392024441226 0.7204 0.8055 2141577 PK04_097126 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 5479800.0 476000.0 0.52 5333560.0 -291.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G09 compound treatment 6282280.0 667546.03174603 0.738112554114893 1.0047 0.9818 2141458 PK04_097127 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 5449240.0 446000.0 0.49 5845880.0 512000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G10 compound treatment 6262640.0 647906.03174603 0.716396402908212 1.1421 0.9953 2141190 PK04_097128 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 5635680.0 632000.0 0.69 5901120.0 567000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G11 compound treatment 5666200.0 51466.0317460299 0.0569065237986057 -0.297 -0.6987 2141333 PK04_097129 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 4665520.0 -338000.0 -0.37 5133240.0 -201000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G12 compound treatment 5871560.0 256826.03174603 0.283975200570702 0.6953 0.9689 2141508 PK04_097130 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 5490840.0 487000.0 0.53 5719040.0 385000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G13 compound treatment 6347560.0 732826.03174603 0.810293325539136 1.1312 0.9241 2141118 PK04_097131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 5803360.0 800000.0 0.88 5605840.0 272000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G14 compound treatment 3358840.0 -2255893.96825397 -2.49436530146855 -4.2659 -1.0 2141927 PK04_097132 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 2768800.0 -2230000.0 -2.45 2895440.0 -2440000.0 -2.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G15 compound treatment 6130760.0 516026.03174603 0.570575322402252 0.5737 0.7575 2141159 PK04_097133 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 5453640.0 450000.0 0.49 5264160.0 -69700.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G16 compound treatment 5547560.0 -67173.9682539701 -0.0742749517187367 -0.0403 -0.1177 2141713 PK04_097134 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 5221240.0 218000.0 0.24 5100640.0 -233000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G17 compound treatment 6335160.0 720426.03174603 0.796582517241639 1.0046 0.9587 2141795 PK04_097135 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 5521960.0 519000.0 0.57 5708120.0 374000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G18 compound treatment 6389800.0 775066.03174603 0.856998530578351 0.7308 0.794 2141553 PK04_097136 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 5300200.0 297000.0 0.33 5417240.0 83400.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G19 mock treatment 6009920.0 395186.03174603 0.436961284122451 0.5252 0.8752 5064440.0 61000.0 0.07 5738360.0 405000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G20 mock treatment 6467160.0 852426.03174603 0.942536282989188 0.4857 0.5136 4975320.0 -28100.0 -0.03 5263520.0 -70300.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G21 compound treatment 6270120.0 655386.03174603 0.724667116300574 0.6401 0.7441 2141819 PK04_097137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 5421240.0 418000.0 0.46 5260520.0 -73300.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G22 compound treatment 5863560.0 248826.03174603 0.275129517798123 0.5361 0.9925 2141516 PK04_097138 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 5334720.0 331000.0 0.36 5623440.0 290000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G23 compound treatment 5932200.0 317466.03174603 0.351025475986848 -0.1764 -0.2933 2141691 PK04_097139 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 4606160.0 -397000.0 -0.44 5113160.0 -221000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 G24 compound treatment 2839320.0 -2775413.96825397 -3.06880394071981 -5.0603 -0.9991 2141155 PK04_097140 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 2321200.0 -2680000.0 -2.94 2585120.0 -2750000.0 -2.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H01 compound treatment 4784160.0 -830573.96825397 -0.918374230292061 -1.2218 -0.9469 2141157 PK04_097141 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 4665000.0 -338000.0 -0.37 4509600.0 -824000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H02 compound treatment 5411440.0 -203293.96825397 -0.224784244094164 -0.0296 -0.1143 2143037 PK04_097142 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 5108640.0 105000.0 0.12 5391880.0 58000.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H03 mock treatment 5683560.0 68826.0317460299 0.0761016554151016 0.5187 0.8022 5554720.0 551000.0 0.6 5551640.0 218000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H04 mock treatment 5807400.0 192666.03174603 0.21303282473462 0.536 0.7487 5626800.0 623000.0 0.68 5366320.0 32500.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H05 compound treatment 2891800.0 -2722933.96825397 -3.0107762617317 -5.3805 -0.9997 2141926 PK04_097143 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 2083160.0 -2920000.0 -3.2 2234480.0 -3100000.0 -3.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H06 compound treatment 5723960.0 109226.03174603 0.120772353416624 0.0993 0.6645 2143177 PK04_097144 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 5078640.0 75200.0 0.08 5302840.0 -31000.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H07 compound treatment 6386680.0 771946.03174603 0.853548714297046 0.7068 0.7783 2141694 PK04_097145 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 5279600.0 276000.0 0.3 5401880.0 68000.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H08 compound treatment 3220880.0 -2393853.96825397 -2.64690910088167 -4.3911 -0.995 2143025 PK04_097146 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 3008840.0 -1990000.0 -2.18 2569360.0 -2760000.0 -2.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H09 compound treatment 211960.0 -5402773.96825397 -5.97390307689012 -9.4609 -0.9978 2141749 PK04_097147 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 217880.0 -4790000.0 -5.24 180160.0 -5150000.0 -5.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H10 compound treatment 5572160.0 -42573.9682539701 -0.0470744771930572 0.2754 0.5338 2143077 PK04_097148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 5012960.0 9540.0 0.01 5845720.0 512000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H11 compound treatment 5432080.0 -182653.96825397 -0.201962382540911 0.0729 0.1788 2141097 PK04_097149 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4980440.0 -23000.0 -0.03 5686000.0 352000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H12 compound treatment 6282920.0 668186.03174603 0.7388202087367 0.5562 0.5881 2142913 PK04_097150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 5473240.0 470000.0 0.51 5044960.0 -289000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H13 compound treatment 5025680.0 -589053.96825397 -0.65132306738791 -1.333 -0.9179 2141401 PK04_097151 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 3886400.0 -1120000.0 -1.22 4901120.0 -433000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H14 compound treatment 5561840.0 -52893.9682539701 -0.0584854079696837 0.0746 0.3299 2143093 PK04_097152 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5201200.0 198000.0 0.22 5305080.0 -28800.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H15 compound treatment 6148280.0 533546.03174603 0.5899473676742 0.9253 0.9802 2141777 PK04_097153 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 5578280.0 575000.0 0.63 5715600.0 382000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H16 compound treatment 5246600.0 -368133.96825397 -0.407049537623148 -0.6353 -0.9833 2143865 PK04_097154 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 4618040.0 -385000.0 -0.42 5063520.0 -270000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H17 compound treatment 5928480.0 313746.03174603 0.346912233497599 0.8351 0.9558 2141142 PK04_097155 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 5378720.0 375000.0 0.41 6019880.0 686000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H18 compound treatment 6026560.0 411826.03174603 0.455360304289414 0.5163 0.6436 2143925 PK04_097156 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 5580280.0 577000.0 0.63 5141720.0 -192000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H19 mock treatment 6026040.0 411306.03174603 0.454785334909197 0.4515 0.8848 5149480.0 146000.0 0.16 5500520.0 167000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H20 mock treatment 5529240.0 -85493.9682539701 -0.094531565267942 0.3664 0.6715 5238480.0 235000.0 0.26 5803840.0 470000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H21 compound treatment 6142600.0 527866.03174603 0.583666932905669 0.6944 0.7933 2141168 PK04_097157 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 4973760.0 -29700.0 -0.03 5983080.0 649000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H22 compound treatment 5328760.0 -285973.96825397 -0.316204375548765 0.043 0.0941 2143057 PK04_097158 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 5065520.0 62100.0 0.07 5655400.0 322000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H23 compound treatment 5260800.0 -353933.96825397 -0.391348450701821 -0.7289 -0.9953 2141804 PK04_097159 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 4645360.0 -358000.0 -0.39 4856600.0 -477000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 H24 compound treatment 5264080.0 -350653.96825397 -0.387721720765064 -0.5093 -0.686 2142649 PK04_097160 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 4436880.0 -567000.0 -0.62 5459440.0 126000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I01 compound treatment 5132080.0 -482653.96825397 -0.533675486512613 -1.0481 -0.9954 2141890 PK04_097161 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 4451080.0 -552000.0 -0.6 4659440.0 -674000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I02 compound treatment 5448840.0 -165893.96825397 -0.183430677132358 0.0993 0.3035 2141465 PK04_097162 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 5231320.0 228000.0 0.25 5439400.0 106000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I03 compound treatment 5423440.0 -191293.96825397 -0.211515719935296 0.0344 0.0892 2141772 PK04_097163 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 5294760.0 291000.0 0.32 5286080.0 -47800.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I04 compound treatment 5685760.0 71026.0317460299 0.0785342181775607 -0.0485 -0.3002 2141343 PK04_097164 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 4982280.0 -21100.0 -0.02 5194880.0 -139000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I05 mock treatment 5731040.0 116306.03174603 0.128600782670356 -0.3036 -0.4188 5055280.0 51900.0 0.06 4625160.0 -709000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I06 mock treatment 5702360.0 87626.0317460299 0.0968890099306616 0.3667 0.9026 5316280.0 313000.0 0.34 5528800.0 195000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I07 compound treatment 5581560.0 -33173.9682539701 -0.0366807999352771 0.1638 0.4607 2141794 PK04_097165 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 5325000.0 322000.0 0.35 5302160.0 -31700.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I08 compound treatment 3696360.0 -1918373.96825397 -2.12116594529345 -3.3956 -0.9972 2141922 PK04_097166 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3184080.0 -1820000.0 -1.99 3572360.0 -1760000.0 -1.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I09 compound treatment 5538200.0 -76533.9682539701 -0.0846244005626538 -0.1432 -0.5057 2141780 PK04_097167 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 5086560.0 83100.0 0.09 5080280.0 -254000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I10 compound treatment 3080920.0 -2533813.96825397 -2.80166432098793 -3.2838 -0.9466 2141799 PK04_097168 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 3774960.0 -1230000.0 -1.35 3798680.0 -1540000.0 -1.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I11 compound treatment 5082240.0 -532493.96825397 -0.588784090185778 -0.4617 -0.6936 2141177 PK04_097169 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 5082960.0 79500.0 0.09 5036880.0 -297000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I12 compound treatment 2839080.0 -2775653.96825397 -3.06906931120299 -4.7409 -0.9907 2141747 PK04_097170 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 2982680.0 -2020000.0 -2.21 2414880.0 -2920000.0 -2.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I13 compound treatment 5170240.0 -444493.96825397 -0.491481579687412 -0.2725 -0.5159 2141423 PK04_097171 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 5136960.0 134000.0 0.15 5207520.0 -126000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I14 compound treatment 5474080.0 -140653.96825397 -0.155522547984872 -0.0491 -0.1641 2141775 PK04_097172 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 5197600.0 194000.0 0.21 5192120.0 -142000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I15 compound treatment 5773240.0 158506.03174603 0.175261759295709 0.2555 0.8141 2141538 PK04_097173 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 5009840.0 6420.0 0.01 5593120.0 259000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I16 compound treatment 5540440.0 -74293.9682539701 -0.0821476093863318 0.0086 0.0132 2065871 PK04_097174 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 5465080.0 462000.0 0.51 4926840.0 -407000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I17 compound treatment 4958720.0 -656013.96825397 -0.725361432194394 -1.4981 -0.9882 2141729 PK04_097175 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 4048120.0 -955000.0 -1.05 4513520.0 -820000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I18 compound treatment 5490800.0 -123933.96825397 -0.137035070990183 -0.0219 -0.1349 2141892 PK04_097176 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 5081280.0 77900.0 0.09 5347720.0 13900.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I19 compound treatment 5234480.0 -380253.96825397 -0.420450747023605 -0.374 -0.8293 2141687 PK04_097177 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 4882160.0 -121000.0 -0.13 5239720.0 -94100.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I20 compound treatment 5514960.0 -99773.9682539701 -0.110321109016995 -0.4249 -0.9005 2141680 PK04_097178 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 4796280.0 -207000.0 -0.23 4936560.0 -397000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I21 mock treatment 5398480.0 -216253.96825397 -0.239114250185741 -0.4198 -0.7481 4540240.0 -463000.0 -0.51 5353080.0 19200.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I22 mock treatment 5782320.0 167586.03174603 0.185301609242586 -0.2795 -0.5277 4601760.0 -402000.0 -0.44 5105160.0 -229000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I23 compound treatment 4841320.0 -773413.96825397 -0.855171826881986 -1.382 -0.9646 2141841 PK04_097179 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 4061120.0 -942000.0 -1.03 4829040.0 -505000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 I24 compound treatment 2670560.0 -2944173.96825397 -3.25540361880736 -4.929 -0.9922 2141766 PK04_097180 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 2356040.0 -2650000.0 -2.9 2959720.0 -2370000.0 -2.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J01 compound treatment 4502960.0 -1111773.96825397 -1.2292999797482 -1.6004 -0.9665 2141705 PK04_097181 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 4168320.0 -835000.0 -0.91 4707880.0 -626000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J02 compound treatment 4809200.0 -805533.96825397 -0.89068724321389 -1.6191 -0.9994 2143397 PK04_097182 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 4129520.0 -874000.0 -0.96 4380640.0 -953000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J03 compound treatment 5005440.0 -609293.96825397 -0.673702644802534 -0.9005 -0.9762 2141179 PK04_097183 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4642160.0 -361000.0 -0.4 4845200.0 -489000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J04 compound treatment 5338600.0 -276133.96825397 -0.305324185738493 -0.6191 -0.9946 2144337 PK04_097184 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 4659720.0 -344000.0 -0.38 4944640.0 -389000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J05 mock treatment 5520360.0 -94373.9682539701 -0.104350273145504 0.1304 0.2038 5532840.0 529000.0 0.58 5085160.0 -249000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J06 mock treatment 5915840.0 301106.03174603 0.332936054716925 0.2776 0.6024 4876600.0 -127000.0 -0.14 5619520.0 286000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J07 compound treatment 5634400.0 19666.0317460299 0.0217449347776053 0.2694 0.6959 2141805 PK04_097185 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 5351600.0 348000.0 0.38 5397240.0 63400.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J08 compound treatment 5092280.0 -522453.96825397 -0.577682758306192 -0.5537 -0.8559 2143365 PK04_097186 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 4758240.0 -245000.0 -0.27 5221400.0 -112000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J09 compound treatment 4542280.0 -1072453.96825397 -1.18582344892098 -1.7392 -0.9584 2141901 PK04_097187 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3867440.0 -1140000.0 -1.24 4753320.0 -581000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J10 compound treatment 3861600.0 -1753133.96825397 -1.93845836762584 -2.6342 -0.9817 2144881 PK04_097188 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 3807520.0 -1200000.0 -1.31 4024000.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J11 compound treatment 3548920.0 -2065813.96825397 -2.28419187879208 -2.4551 -0.9177 2141717 PK04_097189 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 4139840.0 -864000.0 -0.95 4315120.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J12 compound treatment 3393600.0 -2221133.96825397 -2.4559308098217 -4.06 -0.999 2143405 PK04_097190 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 2833920.0 -2170000.0 -2.38 3141400.0 -2190000.0 -2.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J13 compound treatment 5808080.0 193346.03174603 0.213784707770289 0.3054 0.6223 2141188 PK04_097191 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 5393560.0 390000.0 0.43 5222160.0 -112000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J14 compound treatment 5513360.0 -101373.96825397 -0.112090245571511 -0.336 -0.813 2142929 PK04_097192 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 4930080.0 -73300.0 -0.08 4945600.0 -388000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J15 compound treatment 5002160.0 -612573.96825397 -0.677329374739291 -0.9551 -0.9455 2141365 PK04_097193 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 4369680.0 -634000.0 -0.69 5051880.0 -282000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J16 compound treatment 3998040.0 -1616693.96825397 -1.78759524793951 -2.5268 -0.9747 2144325 PK04_097194 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 4090440.0 -913000.0 -1.0 3750400.0 -1580000.0 -1.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J17 compound treatment 2594000.0 -3020733.96825397 -3.34005680294094 -5.4409 -0.9984 2141221 PK04_097195 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 2346880.0 -2660000.0 -2.91 2170480.0 -3160000.0 -3.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J18 compound treatment 5816440.0 201706.03174603 0.223028446267634 -0.2759 -0.4423 2143377 PK04_097196 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 4485680.0 -518000.0 -0.57 5200360.0 -133000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J19 compound treatment 5609000.0 -5733.96825397015 -0.00634010802533213 -0.3007 -0.7145 2141815 PK04_097197 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 4632000.0 -371000.0 -0.41 5226520.0 -107000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J20 compound treatment 4412040.0 -1202693.96825397 -1.32983116445856 -2.3721 -0.9983 2142585 PK04_097198 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 3650680.0 -1350000.0 -1.48 4041040.0 -1290000.0 -1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J21 mock treatment 5198880.0 -415853.96825397 -0.45981403536158 -0.4194 -0.6601 4626200.0 -377000.0 -0.41 5479880.0 146000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J22 mock treatment 5316600.0 -298133.96825397 -0.329649813363084 -0.2116 -0.39 4708800.0 -295000.0 -0.32 5618560.0 285000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J23 compound treatment 4978240.0 -636493.96825397 -0.703777966229302 -0.8012 -0.93 2141186 PK04_097199 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 4764760.0 -239000.0 -0.26 4912800.0 -421000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 J24 compound treatment 4621720.0 -993013.96825397 -1.09798581898927 -1.4102 -0.9703 2144237 PK04_097200 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 4422920.0 -580000.0 -0.64 4627520.0 -706000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K01 compound treatment 4843800.0 -770933.96825397 -0.852429665222487 -1.2885 -0.9615 2141164 PK04_097201 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 4151800.0 -852000.0 -0.93 4888800.0 -445000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K02 compound treatment 5521080.0 -93653.9682539701 -0.103554161695972 -0.5258 -0.8868 2141443 PK04_097202 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 4555560.0 -448000.0 -0.49 5018360.0 -315000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K03 compound treatment 4368520.0 -1246213.96825397 -1.37795167874139 -2.0568 -0.9928 2141548 PK04_097203 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4062040.0 -941000.0 -1.03 4184360.0 -1150000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K04 compound treatment 5526920.0 -87813.9682539701 -0.0970968132719898 -0.2223 -0.4704 2141351 PK04_097204 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 5140080.0 137000.0 0.15 4897840.0 -436000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K05 compound treatment 5801240.0 186506.03174603 0.206221648999735 -0.1471 -0.3813 2141786 PK04_097205 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 4786200.0 -217000.0 -0.24 5111440.0 -222000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K06 compound treatment 4505440.0 -1109293.96825397 -1.2265578180887 -2.1507 -0.99 2141746 PK04_097206 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 3665480.0 -1340000.0 -1.47 4304240.0 -1030000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K07 mock treatment 5446360.0 -168373.96825397 -0.186172838791858 0.1773 0.4425 5186760.0 183000.0 0.2 5625320.0 291000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K08 mock treatment 5616920.0 2186.03174602985 0.00241711791952081 0.2188 0.479 4935720.0 -67700.0 -0.07 5782960.0 449000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K09 compound treatment 2507560.0 -3107173.96825397 -3.43563440529865 -5.2405 -0.9954 2141350 PK04_097207 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 2472920.0 -2530000.0 -2.77 2474160.0 -2860000.0 -2.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K10 compound treatment 386320.0 -5228413.96825397 -5.78111142086176 -8.9076 -0.9961 2141331 PK04_097208 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 645120.0 -4360000.0 -4.77 476720.0 -4860000.0 -4.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K11 compound treatment 5617120.0 2386.03174602985 0.00263825998883528 0.1541 0.6069 2141806 PK04_097209 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 5235000.0 232000.0 0.25 5344400.0 10500.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K12 compound treatment 5552240.0 -62493.9682539701 -0.0691002272967782 -0.2432 -0.889 2141720 PK04_097210 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 4784720.0 -219000.0 -0.24 5221680.0 -112000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K13 compound treatment 3911280.0 -1703453.96825397 -1.88352667760813 -2.8818 -0.9928 2141904 PK04_097211 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 3727480.0 -1280000.0 -1.4 3629400.0 -1700000.0 -1.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K14 compound treatment 4856640.0 -758093.96825397 -0.838232344372498 -1.0811 -0.9636 2141222 PK04_097212 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 4437320.0 -566000.0 -0.62 4921000.0 -413000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K15 mock treatment 5630680.0 15946.0317460299 0.0176316922883562 0.0364 0.724 5001920.0 -1500.0 0.0 5380720.0 46900.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K16 mock treatment 5510720.0 -104013.96825397 -0.115009320886462 0.0177 0.0486 4856280.0 -147000.0 -0.16 5639640.0 306000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K17 compound treatment 5050840.0 -563893.96825397 -0.62350339506815 -1.0664 -0.9992 2141773 PK04_097213 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 4417720.0 -586000.0 -0.64 4753800.0 -580000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K18 compound treatment 5556520.0 -58213.9682539701 -0.0643677870134486 -0.346 -0.8534 2141524 PK04_097214 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 4674560.0 -329000.0 -0.36 5159640.0 -174000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K19 compound treatment 4269760.0 -1344973.96825397 -1.48715163256887 -2.5454 -0.9825 2141218 PK04_097215 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 3980920.0 -1020000.0 -1.12 3538440.0 -1800000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K20 compound treatment 4756720.0 -858013.96825397 -0.948714922202006 -1.3172 -0.9796 2141861 PK04_097216 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4485760.0 -518000.0 -0.57 4570760.0 -763000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K21 compound treatment 5352520.0 -262213.96825397 -0.289932697714206 -0.6217 -0.935 2141117 PK04_097217 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 4502000.0 -501000.0 -0.55 5096920.0 -237000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K22 compound treatment 4696280.0 -918453.96825397 -1.01554405554884 -1.4648 -0.9893 2141354 PK04_097218 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4346840.0 -657000.0 -0.72 4534120.0 -800000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K23 mock treatment 4928520.0 -686213.96825397 -0.758753884660878 -1.0852 -0.95 4286560.0 -717000.0 -0.79 4999200.0 -335000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 K24 mock treatment 4560000.0 -1054733.96825397 -1.16623026157972 -1.5199 -0.9483 4097640.0 -906000.0 -0.99 4861080.0 -473000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L01 compound treatment 3982880.0 -1631853.96825397 -1.80435781679355 -2.237 -0.9547 2141684 PK04_097219 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 3863120.0 -1140000.0 -1.25 4515320.0 -819000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L02 compound treatment 4663120.0 -951613.96825397 -1.05220941064118 -0.8988 -0.8088 2143489 PK04_097220 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 4760200.0 -243000.0 -0.27 5096520.0 -237000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L03 compound treatment 189800.0 -5424933.96825397 -5.99840561817016 -9.4931 -0.9978 2141375 PK04_097221 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 197160.0 -4810000.0 -5.26 171680.0 -5160000.0 -5.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L04 compound treatment 5048800.0 -565933.96825397 -0.625759044175157 -0.4879 -0.75 2143313 PK04_097222 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 4847040.0 -156000.0 -0.17 5286000.0 -47900.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L05 compound treatment 4010920.0 -1603813.96825397 -1.77335369867566 -2.1136 -0.866 2141889 PK04_097223 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 3486240.0 -1520000.0 -1.66 5108720.0 -225000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L06 compound treatment 3952400.0 -1662333.96825397 -1.83805986815707 -1.85 -0.874 2144793 PK04_097224 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 4113960.0 -889000.0 -0.97 4943000.0 -391000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L07 mock treatment 3729280.0 -1885453.96825397 -2.08476596068429 -2.5705 -0.9585 3787280.0 -1220000.0 -1.33 4301960.0 -1030000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L08 mock treatment 5453920.0 -160813.96825397 -0.177813668571771 -0.0232 -0.0491 4791560.0 -212000.0 -0.23 5702240.0 368000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L09 compound treatment 5406920.0 -207813.96825397 -0.229782054860671 0.1626 0.2265 2141438 PK04_097225 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 4864960.0 -138000.0 -0.15 5994600.0 661000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L10 compound treatment 5245920.0 -368813.96825397 -0.407801420658818 0.1358 0.1871 2142993 PK04_097226 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 5043720.0 40300.0 0.04 5930600.0 597000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L11 compound treatment 4316560.0 -1298173.96825397 -1.43540438834929 -1.3146 -0.7769 2141185 PK04_097227 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 5051840.0 48400.0 0.05 4442440.0 -891000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L12 compound treatment 4745240.0 -869493.96825397 -0.961408476980657 -0.9797 -0.7336 2144653 PK04_097228 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 4172080.0 -831000.0 -0.91 5508080.0 174000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L13 compound treatment 3391000.0 -2223733.96825397 -2.45880565672278 -2.5064 -0.8944 2141893 PK04_097229 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4264680.0 -739000.0 -0.81 4264360.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L14 compound treatment 5144560.0 -470173.96825397 -0.51987622138739 -0.358 -0.5884 2143417 PK04_097230 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 4758800.0 -245000.0 -0.27 5500960.0 167000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L15 mock treatment 5383840.0 -230893.96825397 -0.25530184965956 -0.0726 -0.2049 4915280.0 -88100.0 -0.1 5559080.0 225000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L16 mock treatment 4879840.0 -734893.96825397 -0.81257986433202 -0.3736 -0.431 4899600.0 -104000.0 -0.11 5612120.0 278000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L17 compound treatment 5713200.0 98466.0317460299 0.108874910087506 -0.0042 -0.0139 2141152 PK04_097231 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 4773440.0 -230000.0 -0.25 5469000.0 135000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L18 compound treatment 5235920.0 -378813.96825397 -0.418858524124541 -0.4472 -0.8632 2143325 PK04_097232 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 4729680.0 -274000.0 -0.3 5278080.0 -55800.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L19 compound treatment 4848880.0 -765853.96825397 -0.8468126566619 -1.0989 -0.8654 2141709 PK04_097233 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 4146040.0 -857000.0 -0.94 5216720.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L20 compound treatment 4619280.0 -995453.96825397 -1.10068375223491 -1.6909 -0.9808 2142773 PK04_097234 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 4362240.0 -641000.0 -0.7 4211960.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L21 compound treatment 5019520.0 -595213.96825397 -0.658134243122795 -0.6856 -0.8999 2141174 PK04_097235 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4706960.0 -296000.0 -0.32 5129960.0 -204000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L22 compound treatment 4890400.0 -724333.96825397 -0.800903563072216 -0.6409 -0.7488 2142985 PK04_097236 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 4727840.0 -276000.0 -0.3 5326480.0 -7370.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L23 mock treatment 5016520.0 -598213.96825397 -0.661451374162512 -1.1253 -0.9405 4153200.0 -850000.0 -0.93 4978600.0 -355000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 L24 mock treatment 4723760.0 -890973.96825397 -0.985159135225031 -1.2535 -0.9556 4321960.0 -681000.0 -0.75 4895760.0 -438000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M01 compound treatment 4835800.0 -778933.96825397 -0.861275347995066 -1.0874 -0.9301 2141838 PK04_097237 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 4329920.0 -673000.0 -0.74 5050280.0 -284000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M02 compound treatment 5093360.0 -521373.96825397 -0.576488591131894 -0.6403 -0.889 2141189 PK04_097238 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 4623920.0 -379000.0 -0.42 5217280.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M03 compound treatment 3550880.0 -2063853.96825397 -2.2820246865128 -3.4402 -0.9942 2141724 PK04_097239 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 3379480.0 -1620000.0 -1.78 3442480.0 -1890000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M04 compound treatment 4924280.0 -690453.96825397 -0.763442096530345 -0.9538 -0.9381 2141153 PK04_097240 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 4444680.0 -559000.0 -0.61 5058160.0 -276000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M05 compound treatment 5666280.0 51546.0317460299 0.0569949806263315 -0.1228 -0.548 2141436 PK04_097241 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 4813880.0 -190000.0 -0.21 5272000.0 -61900.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M06 compound treatment 4745320.0 -869413.96825397 -0.961320020152931 -0.8537 -0.8151 2141769 PK04_097242 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 4639880.0 -364000.0 -0.4 5215120.0 -119000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M07 compound treatment 2732000.0 -2882733.96825397 -3.18746877511396 -2.5303 -0.7627 2141771 PK04_097243 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 4224120.0 -779000.0 -0.85 4993440.0 -340000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M08 compound treatment 2752840.0 -2861893.96825397 -3.16442577149139 -4.5113 -0.9875 2141480 PK04_097244 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 2741200.0 -2260000.0 -2.48 3169640.0 -2160000.0 -2.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M09 mock treatment 5212560.0 -402173.96825397 -0.444687917820471 -0.2382 -0.4354 4812960.0 -190000.0 -0.21 5573760.0 240000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M10 mock treatment 5449880.0 -164853.96825397 -0.182280738371923 0.3115 0.4553 5063320.0 59900.0 0.07 5987760.0 654000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M11 compound treatment 3170960.0 -2443773.96825397 -2.70210616138256 -2.652 -0.8794 2141571 PK04_097245 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4097480.0 -906000.0 -0.99 4437960.0 -896000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M12 compound treatment 2645840.0 -2968893.96825397 -3.28273677857463 -5.0308 -0.9887 2141879 PK04_097246 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 2133360.0 -2870000.0 -3.14 3054280.0 -2280000.0 -2.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M13 mock treatment 5957760.0 343026.03174603 0.379287432445237 0.4024 0.7513 4952000.0 -51400.0 -0.06 5706600.0 373000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M14 mock treatment 5528960.0 -85773.9682539701 -0.0948411641649823 0.1809 0.1742 4548640.0 -455000.0 -0.5 6236800.0 903000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M15 compound treatment 2995360.0 -2619373.96825397 -2.89626889824066 -2.741 -0.853 2141832 PK04_097247 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3852840.0 -1150000.0 -1.26 4744680.0 -589000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M16 compound treatment 4699960.0 -914773.96825397 -1.01147504147345 -0.924 -0.7271 2141542 PK04_097248 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 4316760.0 -687000.0 -0.75 5496280.0 162000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M17 compound treatment 3886880.0 -1727853.96825397 -1.91050601006449 -2.9631 -0.9965 2141399 PK04_097249 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 3501240.0 -1500000.0 -1.65 3762760.0 -1570000.0 -1.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M18 compound treatment 5100080.0 -514653.96825397 -0.569058217602928 -0.7088 -0.9618 2141903 PK04_097250 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 4733960.0 -269000.0 -0.3 4971640.0 -362000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M19 compound treatment 398400.0 -5216333.96825397 -5.76775443987517 -9.0355 -0.9972 2141716 PK04_097251 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 467600.0 -4540000.0 -4.97 436400.0 -4900000.0 -4.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M20 compound treatment 5197680.0 -417053.96825397 -0.461140887777467 -0.3867 -0.6267 2141203 PK04_097252 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 4661200.0 -342000.0 -0.37 5499400.0 166000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M21 compound treatment 5219200.0 -395533.96825397 -0.43734600111923 -0.0039 -0.0067 2141110 PK04_097253 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 5064880.0 61500.0 0.07 5695920.0 362000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M22 compound treatment 3861880.0 -1752853.96825397 -1.9381487687288 -2.8993 -0.9912 2141731 PK04_097254 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 3458720.0 -1540000.0 -1.69 3946920.0 -1390000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M23 compound treatment 5115400.0 -499333.96825397 -0.552118735093439 -0.9083 -0.9842 2141095 PK04_097255 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4434160.0 -569000.0 -0.62 4937600.0 -396000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 M24 compound treatment 4262560.0 -1352173.96825397 -1.49511274706419 -2.0387 -0.981 2141894 PK04_097256 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4007520.0 -996000.0 -1.09 4391760.0 -942000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N01 compound treatment 4633280.0 -981453.96825397 -1.0852038073829 -0.6375 -0.5857 2141340 PK04_097257 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 4941840.0 -61600.0 -0.07 5382200.0 48300.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N02 compound treatment 5942640.0 327906.03174603 0.362569092005064 -0.4478 -0.4926 2142089 PK04_097258 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 4343200.0 -660000.0 -0.72 4920120.0 -414000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N03 compound treatment 5096200.0 -518533.96825397 -0.573348373747628 -0.4541 -0.4648 2141511 PK04_097259 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 4404720.0 -599000.0 -0.66 5774760.0 441000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N04 compound treatment 5784520.0 169786.03174603 0.187734172005045 0.683 0.9026 2144305 PK04_097260 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 5590400.0 587000.0 0.64 5685120.0 351000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N05 compound treatment 5186120.0 -428613.96825397 -0.473922899383843 -0.611 -0.6956 2141839 PK04_097261 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 5132680.0 129000.0 0.14 4610480.0 -723000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N06 compound treatment 5484040.0 -130693.96825397 -0.144509672933012 0.5693 0.5545 2142057 PK04_097262 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 5925080.0 922000.0 1.01 5454680.0 121000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N07 compound treatment 5154080.0 -460653.96825397 -0.509349858888021 -0.6631 -0.8776 2141431 PK04_097263 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 4500200.0 -503000.0 -0.55 5246040.0 -87800.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N08 compound treatment 5115480.0 -499253.96825397 -0.552030278265714 -0.3555 -0.5714 2144369 PK04_097264 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 4791360.0 -212000.0 -0.23 5501800.0 168000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N09 mock treatment 5054920.0 -559813.96825397 -0.618992096854135 -0.2595 -0.2702 4613040.0 -390000.0 -0.43 5928760.0 595000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N10 mock treatment 5434080.0 -180653.96825397 -0.199750961847766 0.3928 0.5812 5294200.0 291000.0 0.32 5893440.0 560000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N11 compound treatment 6134560.0 519826.03174603 0.574777021719227 0.4878 0.6407 2141527 PK04_097265 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 4828840.0 -175000.0 -0.19 5793520.0 460000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N12 compound treatment 5253880.0 -360853.96825397 -0.398999966300102 1.0845 0.6166 2144009 PK04_097266 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 6420280.0 1420000.0 1.55 6057000.0 723000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N13 mock treatment 6156080.0 541346.03174603 0.598571908377464 -0.2732 -0.2623 4765800.0 -238000.0 -0.26 4525240.0 -809000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N14 mock treatment 5135920.0 -478813.96825397 -0.529429558781775 -0.3914 -0.3062 4187640.0 -816000.0 -0.89 6076160.0 742000.0 0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N15 compound treatment 5034720.0 -580013.96825397 -0.641327445854896 -0.3665 -0.4181 2141907 PK04_097267 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 4620680.0 -383000.0 -0.42 5758080.0 424000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N16 compound treatment 4301720.0 -1313013.96825397 -1.45181312989242 -1.8605 -0.9688 2143157 PK04_097268 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 4267960.0 -735000.0 -0.81 4372080.0 -962000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N17 compound treatment 4516720.0 -1098013.96825397 -1.21408540537937 -0.3804 -0.2599 2141544 PK04_097269 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 4793920.0 -209000.0 -0.23 6115680.0 782000.0 0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N18 compound treatment 5548920.0 -65813.9682539701 -0.0727711856473983 0.1422 0.5626 2144297 PK04_097270 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 5092520.0 89100.0 0.1 5554480.0 221000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N19 compound treatment 4557440.0 -1057293.96825397 -1.16906088006694 -1.0808 -0.7779 2141483 PK04_097271 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 4319080.0 -684000.0 -0.75 5380160.0 46300.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N20 compound treatment 4855960.0 -758773.96825397 -0.838984227408167 -0.9815 -0.9395 2142217 PK04_097272 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 4526600.0 -477000.0 -0.52 4996200.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N21 compound treatment 5053840.0 -560893.96825397 -0.620186264028433 -0.7587 -0.8138 2141887 PK04_097273 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 4367720.0 -636000.0 -0.7 5336080.0 2230.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N22 compound treatment 4502400.0 -1112333.96825397 -1.22991917754228 -1.3658 -0.7875 2143065 PK04_097274 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 3889560.0 -1110000.0 -1.22 5417640.0 83800.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N23 compound treatment 5029880.0 -584853.96825397 -0.646679083932306 -0.7803 -0.8577 2141817 PK04_097275 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 4422600.0 -581000.0 -0.64 5265400.0 -68500.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 N24 compound treatment 4601520.0 -1013213.96825397 -1.12032116799003 -1.7955 -0.9979 2144333 PK04_097276 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 4132040.0 -871000.0 -0.95 4302280.0 -1030000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O01 compound treatment 4492640.0 -1122093.96825397 -1.24071091052483 -1.7544 -0.9215 2141166 PK04_097277 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 3740520.0 -1260000.0 -1.38 4920440.0 -413000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O02 compound treatment 3501200.0 -2113533.96825397 -2.33695637653051 -2.8679 -0.9454 2141900 PK04_097278 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3459680.0 -1540000.0 -1.69 4397400.0 -936000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O03 compound treatment 4700400.0 -914333.96825397 -1.01098852892096 -1.5212 -0.9943 2141790 PK04_097279 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 4254400.0 -749000.0 -0.82 4533200.0 -801000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O04 compound treatment 3058600.0 -2556133.96825397 -2.82634377592343 -4.3026 -0.9952 2141883 PK04_097280 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 2863000.0 -2140000.0 -2.34 3060040.0 -2270000.0 -2.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O05 compound treatment 4306240.0 -1308493.96825397 -1.44681531912591 -1.0966 -0.7228 2141427 PK04_097281 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 4586360.0 -417000.0 -0.46 5338080.0 4230.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O06 compound treatment 5455440.0 -159293.96825397 -0.176132988844981 -0.6954 -0.904 2141093 PK04_097282 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 4649360.0 -354000.0 -0.39 4695520.0 -638000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O07 compound treatment 4410520.0 -1204213.96825397 -1.33151184418535 -1.0972 -0.7684 2141812 PK04_097283 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4535200.0 -468000.0 -0.51 5277880.0 -56000.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O08 compound treatment 5003920.0 -610813.96825397 -0.675383324529324 -0.4098 -0.5666 2141430 PK04_097284 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 4821360.0 -182000.0 -0.2 5498240.0 164000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O09 compound treatment 4645280.0 -969453.96825397 -1.07193528322403 -0.9676 -0.8056 2141454 PK04_097285 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 4512080.0 -491000.0 -0.54 5268080.0 -65800.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O10 compound treatment 5852520.0 237786.03174603 0.262922475571964 -0.0394 -0.0573 2141529 PK04_097286 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 4471080.0 -532000.0 -0.58 5584760.0 251000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O11 mock treatment 5046360.0 -568373.96825397 -0.628456977420794 -0.1788 -0.1958 4746720.0 -257000.0 -0.28 5931640.0 598000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O12 mock treatment 5562000.0 -52733.9682539701 -0.0583084943142321 -0.2012 -0.2604 4391240.0 -612000.0 -0.67 5712640.0 379000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O13 compound treatment 5072280.0 -542453.96825397 -0.599796965237639 -1.0647 -0.9996 2141368 PK04_097287 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 4420480.0 -583000.0 -0.64 4730080.0 -604000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O14 compound treatment 3606960.0 -2007773.96825397 -2.22001645027702 -3.5199 -0.9978 2141362 PK04_097288 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 3250320.0 -1750000.0 -1.92 3384040.0 -1950000.0 -1.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O15 compound treatment 4415760.0 -1198973.96825397 -1.32571792196931 -1.0985 -0.7849 2141460 PK04_097289 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4860840.0 -143000.0 -0.16 4914480.0 -419000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O16 compound treatment 4396480.0 -1218253.96825397 -1.34703601745123 -2.0359 -0.9933 2141860 PK04_097290 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4079920.0 -923000.0 -1.01 4170040.0 -1160000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O17 compound treatment 5344280.0 -270453.96825397 -0.299043750969962 -0.1686 -0.4348 2141175 PK04_097291 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4847320.0 -156000.0 -0.17 5511200.0 177000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O18 compound treatment 5252200.0 -362533.96825397 -0.400857559682343 -0.7092 -0.9319 2141486 PK04_097292 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 4803760.0 -200000.0 -0.22 4727120.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O19 compound treatment 4099560.0 -1515173.96825397 -1.67534353355549 -2.2867 -0.9818 2141156 PK04_097293 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 3906920.0 -1100000.0 -1.2 4253160.0 -1080000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O20 compound treatment 4362520.0 -1252213.96825397 -1.38458594082082 -1.537 -0.8748 2141685 PK04_097294 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 4036200.0 -967000.0 -1.06 5116240.0 -218000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O21 compound treatment 4935320.0 -679413.96825397 -0.751235054304186 -0.7595 -0.7959 2141094 PK04_097295 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 4466480.0 -537000.0 -0.59 5357480.0 23600.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O22 compound treatment 4111480.0 -1503253.96825397 -1.66216346622434 -2.4534 -0.9906 2141379 PK04_097296 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 3722120.0 -1280000.0 -1.4 4154000.0 -1180000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O23 compound treatment 344760.0 -5269973.96825397 -5.82706474286531 -9.1013 -0.9962 2141397 PK04_097297 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 217480.0 -4790000.0 -5.24 655000.0 -4680000.0 -4.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 O24 compound treatment 4241280.0 -1373453.96825397 -1.51864226323925 -1.95 -0.9186 2065842 PK04_097298 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 3710960.0 -1290000.0 -1.42 4891920.0 -442000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P01 compound treatment 3200720.0 -2414013.96825397 -2.66920022146857 -3.9789 -0.992 2141898 PK04_097299 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 2935120.0 -2070000.0 -2.27 3383440.0 -1950000.0 -1.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P02 compound treatment 4227320.0 -1387413.96825397 -1.5340779796774 -1.9922 -0.9229 2143305 PK04_097300 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 3686040.0 -1320000.0 -1.44 4861680.0 -472000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P03 compound treatment 4282280.0 -1332453.96825397 -1.47330813902979 -1.7997 -0.896 2141555 PK04_097301 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 3790720.0 -1210000.0 -1.33 5019200.0 -315000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P04 compound treatment 4578600.0 -1036133.96825397 -1.14566404913347 -1.6877 -0.9423 2144945 PK04_097302 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 3829120.0 -1170000.0 -1.29 4844040.0 -490000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P05 compound treatment 229560.0 -5385173.96825397 -5.95444257479044 -9.2142 -0.9964 2141923 PK04_097303 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 510480.0 -4490000.0 -4.92 267320.0 -5070000.0 -5.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P06 compound treatment 4377800.0 -1236933.96825397 -1.3676906867252 -2.5393 -0.9957 2144433 PK04_097304 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 3489280.0 -1510000.0 -1.66 3966360.0 -1370000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P07 compound treatment 4397840.0 -1216893.96825397 -1.34553225137989 -1.8405 -0.97 2141482 PK04_097305 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 3965920.0 -1040000.0 -1.14 4630160.0 -704000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P08 compound treatment 4763680.0 -851053.96825397 -0.941019178189863 -1.6148 -0.9461 2143929 PK04_097306 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 4512960.0 -490000.0 -0.54 4019760.0 -1310000.0 -1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P09 compound treatment 4850320.0 -764413.96825397 -0.845220433762835 -1.1132 -0.7625 2141698 PK04_097307 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 3920400.0 -1080000.0 -1.19 5436560.0 103000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P10 compound treatment 4637200.0 -977533.96825397 -1.08086942282433 -1.4082 -0.9568 2142653 PK04_097308 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 4205720.0 -798000.0 -0.87 4851000.0 -483000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P11 mock treatment 4773360.0 -841373.96825397 -0.930315902035043 -0.9481 -0.7086 4149280.0 -854000.0 -0.94 5556560.0 223000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P12 mock treatment 4715200.0 -899533.96825397 -0.99462401579169 -1.0177 -0.7153 4097360.0 -906000.0 -0.99 5557280.0 223000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P13 compound treatment 2599600.0 -3015133.96825397 -3.33386482500013 -4.8329 -0.9905 2141449 PK04_097309 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 2755520.0 -2250000.0 -2.46 2767840.0 -2570000.0 -2.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P14 compound treatment 4354680.0 -1260053.96825397 -1.39325470993795 -1.5056 -0.8681 2144933 PK04_097310 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 4078560.0 -925000.0 -1.01 5132960.0 -201000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P15 compound treatment 4845600.0 -769133.96825397 -0.850439386598657 -1.3467 -0.8972 2141416 PK04_097311 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 3902680.0 -1100000.0 -1.21 5058240.0 -276000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P16 compound treatment 3077880.0 -2536853.96825397 -2.80502568044151 -3.1796 -0.9311 2144445 PK04_097312 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 4014040.0 -989000.0 -1.08 3720960.0 -1610000.0 -1.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P17 compound treatment 4424480.0 -1190253.96825397 -1.3160761277472 -1.3887 -0.7987 2141453 PK04_097313 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 3966600.0 -1040000.0 -1.14 5379840.0 46000.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P18 compound treatment 2450320.0 -3164413.96825397 -3.49892526553645 -5.6134 -0.9983 2142745 PK04_097314 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 2117840.0 -2890000.0 -3.16 2281000.0 -3050000.0 -3.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P19 compound treatment 4221680.0 -1393053.96825397 -1.54031418603207 -1.7952 -0.8826 2141541 PK04_097315 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 3815320.0 -1190000.0 -1.3 5066800.0 -267000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P20 compound treatment 3627880.0 -1986853.96825397 -2.19688498982673 -3.201 -0.981 2142193 PK04_097316 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 3172840.0 -1830000.0 -2.0 3995880.0 -1340000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P21 compound treatment 4422880.0 -1191853.96825397 -1.31784526430172 -1.0907 -0.7362 2141134 PK04_097317 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 4392080.0 -611000.0 -0.67 5431760.0 97900.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P22 compound treatment 4094920.0 -1519813.96825397 -1.68047402956358 -2.0722 -0.934 2142729 PK04_097318 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 3792080.0 -1210000.0 -1.33 4753840.0 -580000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P23 compound treatment 4039880.0 -1574853.96825397 -1.74133232703892 -2.3802 -0.9488 2141121 PK04_097319 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 3494960.0 -1510000.0 -1.65 4607040.0 -727000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2097 P24 compound treatment 3607160.0 -2007573.96825397 -2.21979530820771 -3.1155 -0.9811 2144273 PK04_097320 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 3336880.0 -1670000.0 -1.83 3987240.0 -1350000.0 -1.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A01 compound treatment 4360360.0 -1124514.09836066 -1.24338687342385 -2.884 -0.973 2141696 PK04_098001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 3713840.0 -2000000.0 -2.19 3479120.0 -1550000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A02 compound treatment 4149320.0 -1335554.09836066 -1.47673598496447 -2.7677 -0.992 2144133 PK04_098002 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 3996560.0 -1720000.0 -1.88 3603680.0 -1430000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A03 compound treatment 4769440.0 -715434.09836066 -0.791062884848035 -1.8617 -0.9548 2141089 PK04_098003 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 4306560.0 -1410000.0 -1.54 4145880.0 -886000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A04 compound treatment 4879720.0 -605154.09836066 -0.669125147828037 -1.384 -0.9797 2142093 PK04_098004 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 4776400.0 -941000.0 -1.03 4336120.0 -696000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A05 compound treatment 3519600.0 -1965274.09836066 -2.17302390440801 -4.0188 -0.9938 2141744 PK04_098005 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3265640.0 -2450000.0 -2.68 2935920.0 -2100000.0 -2.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A06 compound treatment 5052800.0 -432074.09836066 -0.477748801043296 -0.3428 -0.4642 2143237 PK04_098006 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 6023600.0 307000.0 0.34 4581520.0 -450000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A07 compound treatment 5130880.0 -353994.09836066 -0.391414937182928 -0.3346 -0.7733 2141337 PK04_098007 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 5713560.0 -3350.0 0.0 4847920.0 -184000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A08 compound treatment 5021040.0 -463834.09836066 -0.512866161650434 -0.5186 -0.8881 2144129 PK04_098008 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 5580480.0 -136000.0 -0.15 4796560.0 -235000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A09 compound treatment 5386040.0 -98834.0983606596 -0.10928188515153 -0.6086 -0.7845 2141791 PK04_098009 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 5040960.0 -676000.0 -0.74 4827880.0 -204000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A10 compound treatment 4890640.0 -594234.09836066 -0.657050790843467 -0.7043 -0.8979 2144193 PK04_098010 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 5357640.0 -359000.0 -0.39 4862960.0 -169000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A11 compound treatment 3610080.0 -1874794.09836066 -2.07297923225014 -3.8006 -0.9824 2141133 PK04_098011 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 3200600.0 -2520000.0 -2.76 3283760.0 -1750000.0 -1.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A12 compound treatment 4856320.0 -628554.09836066 -0.69499876993783 -0.9016 -0.7955 2143993 PK04_098012 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 4899920.0 -817000.0 -0.89 5059760.0 28000.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A13 mock treatment 5167840.0 -317034.09836066 -0.350547882773614 -0.8613 -0.8987 4950560.0 -766000.0 -0.84 4730840.0 -301000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A14 mock treatment 5529200.0 44325.9016393404 0.0490116080637666 -0.1035 -0.587 5645800.0 -71100.0 -0.08 4881880.0 -150000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A15 compound treatment 5396240.0 -88634.0983606596 -0.0980036396164918 -0.0889 -0.8351 2141695 PK04_098013 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 5682920.0 -34000.0 -0.04 5012960.0 -18800.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A16 compound treatment 4912920.0 -571954.09836066 -0.632415564321835 -0.8138 -0.9707 2144913 PK04_098014 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 5382440.0 -334000.0 -0.37 4622400.0 -409000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A17 compound treatment 5170160.0 -314714.09836066 -0.347982634769567 0.0715 0.1484 2141801 PK04_098015 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 5936600.0 220000.0 0.24 5262200.0 230000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A18 compound treatment 4999680.0 -485194.09836066 -0.536484134653219 -1.1533 -0.9476 2142117 PK04_098016 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 4820480.0 -896000.0 -0.98 4554040.0 -478000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A19 compound treatment 4687000.0 -797874.09836066 -0.882217645819459 -1.376 -0.9958 2141835 PK04_098017 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 4989320.0 -728000.0 -0.8 4329920.0 -702000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A20 compound treatment 5020680.0 -464194.09836066 -0.5132642173752 -0.8861 -0.9975 2144205 PK04_098018 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 5209760.0 -507000.0 -0.56 4567200.0 -465000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A21 compound treatment 2139000.0 -3345874.09836066 -3.69956760888578 -6.3031 -0.9988 2141920 PK04_098019 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 2225640.0 -3490000.0 -3.82 1649440.0 -3380000.0 -3.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A22 compound treatment 4249560.0 -1235314.09836066 -1.36589957982406 -2.1079 -0.9884 2141945 PK04_098020 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 4846800.0 -870000.0 -0.95 3704320.0 -1330000.0 -1.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A23 compound treatment 4496720.0 -988154.09836066 -1.09261221056524 -1.5894 -0.991 2141111 PK04_098021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4962040.0 -755000.0 -0.83 4201040.0 -831000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 A24 compound treatment 3510240.0 -1974634.09836066 -2.18337335325193 -3.2176 -0.9924 2143385 PK04_098022 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 4178120.0 -1540000.0 -1.69 3333280.0 -1700000.0 -1.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B01 compound treatment 2833360.0 -2651514.09836066 -2.93180657263981 -4.679 -0.9861 2142845 PK04_098023 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 2879520.0 -2840000.0 -3.11 2973880.0 -2060000.0 -2.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B02 compound treatment 5335480.0 -149394.09836066 -0.165186600274227 -0.0989 -0.4269 2143009 PK04_098024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 5818960.0 102000.0 0.11 4914280.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B03 compound treatment 5287320.0 -197554.09836066 -0.218437610565151 -0.0853 -0.3268 2144209 PK04_098025 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5835560.0 119000.0 0.13 4972720.0 -59000.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B04 compound treatment 5661600.0 176725.90163934 0.195407657949944 0.14 0.6928 2142037 PK04_098026 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 5763840.0 46900.0 0.05 5027440.0 -4290.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B05 compound treatment 5676840.0 191965.90163934 0.212258683631707 0.4117 0.8367 2144313 PK04_098027 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 6118400.0 401000.0 0.44 5092640.0 60900.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B06 compound treatment 4470720.0 -1014154.09836066 -1.12136067957612 -1.376 -0.9531 2143245 PK04_098028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 5253640.0 -463000.0 -0.51 4279840.0 -752000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B07 compound treatment 5177800.0 -307074.09836066 -0.339535007721754 0.079 0.1597 2144661 PK04_098029 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 5852480.0 136000.0 0.15 5358480.0 327000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B08 compound treatment 5296880.0 -187994.09836066 -0.20786701965192 -0.124 -0.1836 2143409 PK04_098030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5298960.0 -418000.0 -0.46 5481000.0 449000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B09 compound treatment 5157360.0 -327514.09836066 -0.362135727205692 -0.4233 -0.8796 2144745 PK04_098031 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 5432680.0 -284000.0 -0.31 4972120.0 -59600.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B10 compound treatment 5760800.0 275925.90163934 0.305094124329921 0.9074 0.959 2143049 PK04_098032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 6290800.0 574000.0 0.63 5667600.0 636000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B11 compound treatment 5896680.0 411805.90163934 0.45533804622217 0.9996 0.9881 2143257 PK04_098033 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 6270640.0 554000.0 0.61 5699040.0 667000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B12 compound treatment 4704680.0 -780194.09836066 -0.86266868689206 -1.8056 -0.9892 2141502 PK04_098034 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 4585120.0 -1130000.0 -1.24 4010080.0 -1020000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B13 mock treatment 5718960.0 234085.90163934 0.258831203429334 0.6275 0.8769 6301360.0 584000.0 0.64 5219000.0 187000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B14 mock treatment 6248720.0 763845.90163934 0.844592316629497 0.9388 0.9264 6014600.0 298000.0 0.33 5485600.0 454000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B15 compound treatment 4987160.0 -497714.09836066 -0.550327628192305 -1.2121 -0.9855 2142113 PK04_098035 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 4944760.0 -772000.0 -0.85 4330800.0 -701000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B16 compound treatment 5839080.0 354205.90163934 0.391649130259603 0.6963 0.9819 2141859 PK04_098036 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 6175080.0 458000.0 0.5 5343280.0 312000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B17 compound treatment 4137280.0 -1347594.09836066 -1.49004873753721 -2.0721 -0.9851 2144033 PK04_098037 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 4782640.0 -934000.0 -1.02 3959760.0 -1070000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B18 compound treatment 5320640.0 -164234.09836066 -0.181595341817361 0.0397 0.0715 2141540 PK04_098038 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 6150320.0 433000.0 0.47 4808280.0 -223000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B19 compound treatment 4270000.0 -1214874.09836066 -1.34329886034012 -1.2509 -0.8337 2144437 PK04_098039 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 5129240.0 -588000.0 -0.64 4852680.0 -179000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B20 compound treatment 2521480.0 -2963394.09836066 -3.27665551552879 -5.2983 -0.998 2144725 PK04_098040 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 2895320.0 -2820000.0 -3.09 2231400.0 -2800000.0 -2.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B21 compound treatment 4989120.0 -495754.09836066 -0.548160435913023 -0.5022 -0.8373 2143413 PK04_098041 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5626240.0 -90700.0 -0.1 4810080.0 -222000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B22 compound treatment 5383680.0 -101194.09836066 -0.11189136156944 -0.1023 -0.6053 2141509 PK04_098042 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 5763280.0 46400.0 0.05 4916000.0 -116000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B23 compound treatment 4908800.0 -576074.09836066 -0.636971090949713 -0.7389 -0.8975 2142009 PK04_098043 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 5258320.0 -459000.0 -0.5 4891640.0 -140000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 B24 compound treatment 4426160.0 -1058714.09836066 -1.17063113261939 -1.2898 -0.927 2141342 PK04_098044 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 5234720.0 -482000.0 -0.53 4498400.0 -533000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C01 compound treatment 4971840.0 -513034.09836066 -0.567267110701793 -1.2781 -0.8999 2141145 PK04_098045 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 4588640.0 -1130000.0 -1.24 4622320.0 -409000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C02 compound treatment 5456840.0 -28034.0983606596 -0.030997592614208 -0.4521 -0.6387 2143097 PK04_098046 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5072520.0 -644000.0 -0.71 4985480.0 -46200.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C03 compound treatment 4597920.0 -886954.09836066 -0.980714323492123 -2.0091 -0.9595 2141834 PK04_098047 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4222440.0 -1490000.0 -1.64 4172200.0 -860000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C04 compound treatment 3062240.0 -2422634.09836066 -2.67873158851633 -4.5561 -0.9891 2142605 PK04_098048 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 2900600.0 -2820000.0 -3.08 2910840.0 -2120000.0 -2.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C05 compound treatment 5135920.0 -348954.09836066 -0.385842157036203 -0.6662 -0.8857 2141398 PK04_098049 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 5140720.0 -576000.0 -0.63 4895120.0 -137000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C06 compound treatment 5799280.0 314405.90163934 0.347641858466024 0.9855 0.9273 2143013 PK04_098050 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 6525400.0 808000.0 0.89 5503920.0 472000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C07 compound treatment 5880880.0 396005.90163934 0.437867822746327 0.8993 0.993 2141793 PK04_098051 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 6203640.0 487000.0 0.53 5616400.0 585000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C08 compound treatment 6275560.0 790685.90163934 0.874269582331499 0.7245 0.6602 2143277 PK04_098052 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 5499320.0 -218000.0 -0.24 5648440.0 617000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C09 compound treatment 3235120.0 -2249754.09836066 -2.48757638380091 -4.2881 -0.9963 2141681 PK04_098053 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 3224000.0 -2490000.0 -2.73 2830080.0 -2200000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C10 compound treatment 2413840.0 -3071034.09836066 -3.39567417723384 -5.2825 -0.9892 2144125 PK04_098054 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 2664440.0 -3050000.0 -3.34 2629280.0 -2400000.0 -2.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C11 mock treatment 6123600.0 638725.90163934 0.706245838066366 0.9075 0.8537 5784960.0 68100.0 0.07 5820040.0 788000.0 0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C12 mock treatment 5482920.0 -1954.09836065955 -0.00216066677560132 0.4283 0.5721 5712680.0 -4230.0 0.0 5777640.0 746000.0 0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C13 compound treatment 3954840.0 -1530034.09836066 -1.69177453316586 -2.7021 -0.9948 2141376 PK04_098055 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 4207960.0 -1510000.0 -1.65 3700600.0 -1330000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C14 compound treatment 6242640.0 757765.90163934 0.837869597722337 0.8655 0.7413 2143897 PK04_098056 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 6448280.0 731000.0 0.8 4892520.0 -139000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C15 mock treatment 5804840.0 319965.90163934 0.353789607992967 0.7995 0.9762 6264440.0 548000.0 0.6 5461480.0 430000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C16 mock treatment 5723800.0 238925.90163934 0.264182841506744 1.1855 0.883 6768560.0 1050000.0 1.15 5666920.0 635000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C17 compound treatment 6031800.0 546925.90163934 0.604741628251025 1.1798 0.9439 2141461 PK04_098057 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 6633440.0 917000.0 1.0 5465160.0 433000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C18 compound treatment 4833520.0 -651354.09836066 -0.720208965839679 -1.4922 -0.9908 2143145 PK04_098058 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 4795600.0 -921000.0 -1.01 4179400.0 -852000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C19 compound treatment 5190480.0 -294394.09836066 -0.325514600527217 -0.8179 -0.976 2141551 PK04_098059 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 5238840.0 -478000.0 -0.52 4466240.0 -565000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C20 compound treatment 5570440.0 85565.9016393404 0.0946111027564099 -0.122 -0.3747 2144941 PK04_098060 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 5722040.0 5130.0 0.01 4721240.0 -310000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C21 compound treatment 2546040.0 -2938834.09836066 -3.24949926941698 -4.8757 -0.9941 2141535 PK04_098061 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 3375520.0 -2340000.0 -2.56 2409680.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C22 compound treatment 4821560.0 -663314.09836066 -0.733433261584684 -1.7712 -0.9793 2142185 PK04_098062 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 4711480.0 -1010000.0 -1.1 3802840.0 -1230000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C23 compound treatment 5146000.0 -338874.09836066 -0.374696596742754 -0.2903 -0.7523 2141425 PK04_098063 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 5669280.0 -47600.0 -0.05 4956120.0 -75600.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 C24 compound treatment 4599640.0 -885234.09836066 -0.978812501696018 -1.4503 -0.9929 2144353 PK04_098064 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 5009680.0 -707000.0 -0.77 4275760.0 -756000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D01 compound treatment 4988400.0 -496474.09836066 -0.548956547362555 -0.9736 -0.9944 2143317 PK04_098065 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 5263880.0 -453000.0 -0.5 4392840.0 -639000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D02 compound treatment 5287480.0 -197394.09836066 -0.2182606969097 -0.4287 -0.95 2144805 PK04_098066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 5389560.0 -327000.0 -0.36 4866600.0 -165000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D03 compound treatment 6005760.0 520885.90163934 0.575948930826281 0.2009 0.1951 2142937 PK04_098067 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 6154120.0 437000.0 0.48 4327440.0 -704000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D04 compound treatment 5749960.0 265085.90163934 0.293108224173076 0.6957 0.9764 2141997 PK04_098068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 6183320.0 466000.0 0.51 5431440.0 400000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D05 compound treatment 5232320.0 -252554.09836066 -0.27925167962663 -0.3417 -0.8182 2144781 PK04_098069 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 5715000.0 -1910.0 0.0 4722280.0 -309000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D06 compound treatment 3341600.0 -2143274.09836066 -2.36984034609789 -4.3172 -0.993 2144025 PK04_098070 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 3067000.0 -2650000.0 -2.9 2833800.0 -2200000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D07 compound treatment 5277040.0 -207834.09836066 -0.229804312927915 -0.5207 -0.9191 2144817 PK04_098071 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 5542880.0 -174000.0 -0.19 4551880.0 -480000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D08 compound treatment 5682000.0 197125.90163934 0.21796414902002 0.3765 0.9486 2144197 PK04_098072 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 5834040.0 117000.0 0.13 5336440.0 305000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D09 compound treatment 5441840.0 -43034.0983606596 -0.0475832478127931 -0.2745 -0.5011 2144761 PK04_098073 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 5228400.0 -489000.0 -0.53 5138520.0 107000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D10 compound treatment 3291280.0 -2193594.09836066 -2.42547969073741 -4.0876 -0.9891 2142125 PK04_098074 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 3202120.0 -2510000.0 -2.75 3138040.0 -1890000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D11 mock treatment 6016200.0 531325.90163934 0.587492546844496 0.9876 0.8355 5810480.0 93600.0 0.1 6048680.0 1020000.0 1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D12 mock treatment 6032280.0 547405.90163934 0.60527236921738 0.2913 0.2592 5061320.0 -656000.0 -0.72 5646760.0 615000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D13 compound treatment 6053840.0 568965.90163934 0.629111484289479 0.4397 0.6185 2143225 PK04_098075 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 5572360.0 -145000.0 -0.16 5321480.0 290000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D14 compound treatment 6538800.0 1053925.90163934 1.1653367739632 1.5233 0.9659 2144233 PK04_098076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 6525600.0 809000.0 0.89 5617200.0 585000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D15 mock treatment 5879280.0 394405.90163934 0.436098686191812 0.3332 0.5558 5523520.0 -193000.0 -0.21 5383360.0 352000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D16 mock treatment 4960120.0 -524754.09836066 -0.580226035963621 0.0981 0.1144 5839200.0 122000.0 0.13 5645680.0 614000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D17 compound treatment 6197320.0 712445.90163934 0.787758804815679 1.6833 0.9904 2143045 PK04_098077 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 6732360.0 1020000.0 1.11 6043800.0 1010000.0 1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D18 compound treatment 5968720.0 483845.90163934 0.534993419589242 0.9172 0.867 2142013 PK04_098078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 6538360.0 821000.0 0.9 5185200.0 153000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D19 compound treatment 5940240.0 455365.90163934 0.503502788918861 0.2432 0.4254 2142213 PK04_098079 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 5850080.0 133000.0 0.15 4804440.0 -227000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D20 compound treatment 5758880.0 274005.90163934 0.302971160464502 0.5063 0.9891 2141447 PK04_098080 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 6026800.0 310000.0 0.34 5265440.0 234000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D21 compound treatment 4800440.0 -684434.09836066 -0.756785864104292 -1.3617 -0.976 2143393 PK04_098081 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 4790760.0 -926000.0 -1.01 4446400.0 -585000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D22 compound treatment 5476760.0 -8114.09836065955 -0.00897184251048694 0.2639 0.7911 2065844 PK04_098082 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 5962680.0 246000.0 0.27 5228000.0 196000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D23 compound treatment 5083880.0 -400994.09836066 -0.443383323471828 -0.8092 -0.9533 2144185 PK04_098083 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 5443840.0 -273000.0 -0.3 4374960.0 -657000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 D24 compound treatment 4734360.0 -750514.09836066 -0.829851203805792 -0.9756 -0.8498 2141197 PK04_098084 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 5653320.0 -63600.0 -0.07 4244320.0 -787000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E01 mock treatment 5738960.0 254085.90163934 0.280945410360781 -0.6253 -0.5264 4684800.0 -1030000.0 -1.13 4798880.0 -233000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E02 mock treatment 5652400.0 167525.90163934 0.185235122761479 -0.1814 -0.4075 5361080.0 -356000.0 -0.39 4922360.0 -109000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E03 compound treatment 5183720.0 -301154.09836066 -0.332989202470046 -1.4155 -0.8573 2141526 PK04_098085 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 4356440.0 -1360000.0 -1.49 4405040.0 -627000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E04 compound treatment 5449520.0 -35354.0983606596 -0.0390913923511175 0.18 0.2564 2142637 PK04_098086 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 5453760.0 -263000.0 -0.29 5668520.0 637000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E05 compound treatment 5721960.0 237085.90163934 0.262148334469051 0.4588 0.7704 2141181 PK04_098087 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 5714920.0 -1990.0 0.0 5564600.0 533000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E06 compound treatment 4709080.0 -775794.09836066 -0.857803561367141 -0.6727 -0.7596 2142777 PK04_098088 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5600120.0 -117000.0 -0.13 4852840.0 -179000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E07 compound treatment 5584560.0 99685.9016393404 0.110223732850011 0.4853 0.8254 2141090 PK04_098089 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 6217240.0 500000.0 0.55 5213480.0 182000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E08 compound treatment 5249840.0 -235034.09836066 -0.259879634354682 -0.809 -0.8097 2144801 PK04_098090 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 4854480.0 -862000.0 -0.94 4835560.0 -196000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E09 mock treatment 5835920.0 351045.90163934 0.388155085564435 0.681 0.9583 5947200.0 230000.0 0.25 5569040.0 537000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E10 mock treatment 6238880.0 754005.90163934 0.833712126819225 1.0026 0.9517 6074080.0 357000.0 0.39 5541640.0 510000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E11 compound treatment 5244600.0 -240274.09836066 -0.265673556570722 -0.1015 -0.1381 2141328 PK04_098091 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 5317400.0 -400000.0 -0.44 5557280.0 526000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E12 compound treatment 4444760.0 -1040114.09836066 -1.15006492017314 -2.5088 -0.9866 2144117 PK04_098092 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 4385160.0 -1330000.0 -1.46 3301000.0 -1730000.0 -1.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E13 compound treatment 5693360.0 208485.90163934 0.230525018557082 0.4394 0.9922 2141750 PK04_098093 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 5928680.0 212000.0 0.23 5329320.0 298000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E14 compound treatment 5946480.0 461605.90163934 0.510402421481473 0.3829 0.7014 2142133 PK04_098094 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5683040.0 -33900.0 -0.04 5220880.0 189000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E15 compound treatment 5213840.0 -271034.09836066 -0.299685206831287 -1.418 -0.7524 2141837 PK04_098095 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 5420840.0 -296000.0 -0.32 3206120.0 -1830000.0 -1.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E16 compound treatment 5204600.0 -280274.09836066 -0.309901970433615 0.3807 0.5047 2143333 PK04_098096 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 6195880.0 479000.0 0.52 5474880.0 443000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E17 mock treatment 5713400.0 228525.90163934 0.252683453902392 0.3073 0.9578 5843360.0 126000.0 0.14 5172280.0 141000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E18 mock treatment 5507560.0 22685.9016393404 0.0250840361639411 0.6066 0.8228 6269240.0 552000.0 0.6 5451000.0 419000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E19 compound treatment 1499640.0 -3985234.09836066 -4.40651457607027 -7.0833 -0.9939 2141392 PK04_098097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1685960.0 -4030000.0 -4.41 1596280.0 -3440000.0 -3.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E20 compound treatment 5832200.0 347325.90163934 0.384041843075186 0.0173 0.0222 2144457 PK04_098098 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 5149920.0 -567000.0 -0.62 5297560.0 266000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E21 compound treatment 5266160.0 -218714.09836066 -0.241834441498622 -0.3306 -0.6905 2141783 PK04_098099 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 5785840.0 68900.0 0.08 4626920.0 -405000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E22 compound treatment 5288200.0 -196674.09836066 -0.217464585460167 -0.5829 -0.9414 2142073 PK04_098100 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 5451720.0 -265000.0 -0.29 4531840.0 -500000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E23 compound treatment 4118760.0 -1366114.09836066 -1.51052649315573 -1.897 -0.9383 2141929 PK04_098101 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 4596600.0 -1120000.0 -1.23 4485440.0 -546000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 E24 compound treatment 4803520.0 -681354.09836066 -0.753380276236849 -0.8625 -0.94 2141993 PK04_098102 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 5368880.0 -348000.0 -0.38 4673560.0 -358000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F01 mock treatment 4882760.0 -602114.09836066 -0.665763788374457 -1.1556 -0.9996 5086720.0 -630000.0 -0.69 4388400.0 -643000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F02 mock treatment 5889600.0 404725.90163934 0.447509616968438 0.3268 0.7111 5811800.0 94900.0 0.1 5046360.0 14600.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F03 compound treatment 4746720.0 -738154.09836066 -0.816184623922158 -1.8357 -0.9285 2142917 PK04_098103 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 4204840.0 -1510000.0 -1.66 4326880.0 -705000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F04 compound treatment 6098000.0 613125.90163934 0.677939653194114 0.6857 0.8916 2142953 PK04_098104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 5921120.0 204000.0 0.22 5316760.0 285000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F05 compound treatment 4510000.0 -974874.09836066 -1.07792837716276 -1.8044 -0.9888 2144897 PK04_098105 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 4608800.0 -1110000.0 -1.21 4200880.0 -831000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F06 compound treatment 5422400.0 -62474.0983606596 -0.0690782569501594 0.3751 0.6126 2144329 PK04_098106 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 5829200.0 112000.0 0.12 5625400.0 594000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F07 compound treatment 3933400.0 -1551474.09836066 -1.71548096299637 -2.4082 -0.9812 2144721 PK04_098107 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 4429760.0 -1290000.0 -1.41 3989400.0 -1040000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F08 compound treatment 5897000.0 412125.90163934 0.455691873533073 0.5061 0.7568 2143969 PK04_098108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 5658160.0 -58700.0 -0.06 5515320.0 484000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F09 mock treatment 6022160.0 537285.90163934 0.594082580510068 0.814 0.983 6092920.0 376000.0 0.41 5434240.0 403000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F10 mock treatment 6887560.0 1402685.90163934 1.55096431443377 1.4737 0.8227 5819720.0 103000.0 0.11 5917480.0 886000.0 0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F11 compound treatment 6065560.0 580685.90163934 0.642070409551307 0.3105 0.458 2141973 PK04_098109 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5537400.0 -180000.0 -0.2 5123640.0 91900.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F12 compound treatment 5984880.0 500005.90163934 0.552861698789851 1.0741 0.9848 2141515 PK04_098110 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 6424080.0 707000.0 0.77 5562880.0 531000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F13 compound treatment 5777560.0 292685.90163934 0.323625829738473 0.2603 0.5988 2144053 PK04_098111 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5596840.0 -120000.0 -0.13 5289560.0 258000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F14 compound treatment 5910360.0 425485.90163934 0.47046416376328 0.9471 0.9904 2143249 PK04_098112 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 6311160.0 594000.0 0.65 5549120.0 517000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F15 compound treatment 3906320.0 -1578554.09836066 -1.74542359918155 -4.0266 -0.9789 2144873 PK04_098113 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 3039080.0 -2680000.0 -2.93 2743560.0 -2290000.0 -2.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F16 compound treatment 6306720.0 821845.90163934 0.908723516730693 0.6182 0.6735 2141199 PK04_098114 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 5829600.0 113000.0 0.12 5070200.0 38500.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F17 mock treatment 5678560.0 193685.90163934 0.214160505427811 0.508 0.8096 5791440.0 74500.0 0.08 5613720.0 582000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F18 mock treatment 5707040.0 222165.90163934 0.245651136098192 0.4836 0.884 6150160.0 433000.0 0.47 5148800.0 117000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F19 compound treatment 3335280.0 -2149594.09836066 -2.37682843548822 -3.5294 -0.9871 2142825 PK04_098115 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 3756360.0 -1960000.0 -2.15 3448200.0 -1580000.0 -1.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F20 compound treatment 6233800.0 748925.90163934 0.828095118258638 0.7337 0.8124 2144217 PK04_098116 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5803800.0 86900.0 0.1 5378080.0 346000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F21 compound treatment 4989360.0 -495514.09836066 -0.547895065429846 -0.982 -0.9832 2144057 PK04_098117 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5073640.0 -643000.0 -0.7 4584840.0 -447000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F22 compound treatment 6068920.0 584045.90163934 0.64578559631579 1.0737 0.8767 2141689 PK04_098118 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 6651040.0 934000.0 1.02 5221920.0 190000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F23 compound treatment 4545000.0 -939874.09836066 -1.03922851503273 -1.8914 -0.9878 2144037 PK04_098119 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 4883840.0 -833000.0 -0.91 3711920.0 -1320000.0 -1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 F24 compound treatment 4655920.0 -828954.09836066 -0.916583123390927 -0.8549 -0.8472 2141464 PK04_098120 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 5370760.0 -346000.0 -0.38 4847400.0 -184000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G01 compound treatment 2613000.0 -2871874.09836066 -3.17546090461049 -5.3098 -0.9839 2141573 PK04_098121 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 2351480.0 -3370000.0 -3.69 2704160.0 -2330000.0 -2.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G02 compound treatment 4476080.0 -1008794.09836066 -1.1154340721185 -1.5189 -0.9538 2144113 PK04_098122 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 4780520.0 -936000.0 -1.03 4543600.0 -488000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G03 mock treatment 5357800.0 -127074.09836066 -0.140507145338733 -0.3185 -0.6781 5308960.0 -408000.0 -0.45 5067240.0 35500.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G04 mock treatment 5838200.0 353325.90163934 0.39067610515462 0.0915 0.201 5504080.0 -213000.0 -0.23 5032520.0 791.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G05 compound treatment 5874640.0 389765.90163934 0.430968190183716 0.8415 0.9907 2141531 PK04_098123 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 6125040.0 408000.0 0.45 5609280.0 578000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G06 compound treatment 2596040.0 -2888834.09836066 -3.19421375208836 -5.3138 -0.9994 2143985 PK04_098124 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 2917280.0 -2800000.0 -3.07 2098520.0 -2930000.0 -2.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G07 compound treatment 5665360.0 180485.90163934 0.199565128853056 0.6804 0.8485 2065843 PK04_098125 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 6391320.0 674000.0 0.74 5271200.0 239000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G08 compound treatment 3070520.0 -2414354.09836066 -2.66957630684672 -4.5598 -0.9764 2144713 PK04_098126 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 2679920.0 -3040000.0 -3.33 3136080.0 -1900000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G09 compound treatment 6336440.0 851565.90163934 0.941585228230823 1.1278 0.9529 2141779 PK04_098127 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 6147920.0 431000.0 0.47 5569600.0 538000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G10 compound treatment 6160360.0 675485.90163934 0.746891750406365 0.8863 0.9458 2142633 PK04_098128 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 6140240.0 423000.0 0.46 5355240.0 324000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G11 compound treatment 459560.0 -5025314.09836066 -5.55654179333323 -9.1832 -0.9959 2141711 PK04_098129 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 490560.0 -5230000.0 -5.72 422520.0 -4610000.0 -4.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G12 compound treatment 5446560.0 -38314.0983606596 -0.0423642949769716 -0.0081 -0.0303 2142689 PK04_098130 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 5900400.0 183000.0 0.2 4859680.0 -172000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G13 compound treatment 6211280.0 726405.90163934 0.803194521253829 1.1657 0.8581 2141802 PK04_098131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 6710560.0 994000.0 1.09 5159000.0 127000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G14 compound treatment 5051720.0 -433154.09836066 -0.478942968217595 -0.5576 -0.9431 2142905 PK04_098132 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 5520720.0 -196000.0 -0.21 4760760.0 -271000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G15 compound treatment 5500120.0 15245.9016393404 0.0168575511854429 0.9686 0.7707 2141192 PK04_098133 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 6763960.0 1050000.0 1.15 5544040.0 512000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G16 compound treatment 5373880.0 -110994.09836066 -0.122727322965849 -0.1608 -0.3606 2142129 PK04_098134 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 5913240.0 196000.0 0.22 4662320.0 -369000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G17 compound treatment 4017560.0 -1467314.09836066 -1.62242438022885 -3.0986 -0.9924 2141728 PK04_098135 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 3796920.0 -1920000.0 -2.1 3395760.0 -1640000.0 -1.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G18 compound treatment 4823760.0 -661114.09836066 -0.731000698822225 -1.2738 -0.9826 2144641 PK04_098136 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 5198760.0 -518000.0 -0.57 4127120.0 -905000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G19 mock treatment 6184120.0 699245.90163934 0.773163428240924 0.7641 0.8688 5867640.0 151000.0 0.17 5415520.0 384000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G20 mock treatment 5889440.0 404565.90163934 0.447332703312987 0.6874 0.9239 5876880.0 160000.0 0.18 5597840.0 566000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G21 compound treatment 5073600.0 -411274.09836066 -0.454750025834592 -0.9141 -0.9929 2141885 PK04_098137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 5242680.0 -474000.0 -0.52 4424640.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G22 compound treatment 5905680.0 420805.90163934 0.465289439341321 0.4783 0.653 2144357 PK04_098138 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 6208080.0 491000.0 0.54 4857560.0 -174000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G23 compound treatment 5411880.0 -72994.0983606596 -0.0807103297961004 -0.3499 -0.8608 2141361 PK04_098139 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 5570080.0 -147000.0 -0.16 4668560.0 -363000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 G24 compound treatment 5274080.0 -210794.09836066 -0.233077215553769 -0.573 -0.9761 2142625 PK04_098140 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 5341920.0 -375000.0 -0.41 4684160.0 -348000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H01 compound treatment 4609440.0 -875434.09836066 -0.967976540299609 -1.3075 -0.9798 2142737 PK04_098141 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 5160320.0 -557000.0 -0.61 4347000.0 -685000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H02 compound treatment 5506400.0 21525.9016393404 0.0238014121619172 -0.2261 -0.7659 2144017 PK04_098142 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 5538520.0 -178000.0 -0.2 4812480.0 -219000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H03 mock treatment 6125680.0 640805.90163934 0.708545715587236 0.5533 0.6133 5488880.0 -228000.0 -0.25 5529400.0 498000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H04 mock treatment 6028640.0 543765.90163934 0.601247583555856 0.5713 0.8641 5903560.0 187000.0 0.2 5214920.0 183000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H05 compound treatment 5807560.0 322685.90163934 0.356797140135643 0.3322 0.5668 2143493 PK04_098143 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 5533520.0 -183000.0 -0.2 5449640.0 418000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H06 compound treatment 5474240.0 -10634.0983606596 -0.0117582325838492 0.3758 0.7858 2141857 PK04_098144 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 6080880.0 364000.0 0.4 5294920.0 263000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H07 compound treatment 6191280.0 706405.90163934 0.781080314322382 1.0881 0.9756 2143497 PK04_098145 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 6118840.0 402000.0 0.44 5692840.0 661000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H08 compound treatment 4956960.0 -527914.09836066 -0.58372008065879 -0.6421 -0.9249 2141183 PK04_098146 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 5501440.0 -215000.0 -0.24 4740240.0 -291000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H09 compound treatment 5468360.0 -16514.0983606596 -0.0182598094216946 0.2 0.4667 2143289 PK04_098147 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 5662680.0 -54200.0 -0.06 5454280.0 423000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H10 compound treatment 5523520.0 38645.9016393404 0.0427311732952357 0.1622 0.2325 2142033 PK04_098148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 5389440.0 -327000.0 -0.36 5626400.0 595000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H11 compound treatment 5581920.0 97045.9016393404 0.10730465753506 0.3729 0.6985 2143345 PK04_098149 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 5731360.0 14500.0 0.02 5552560.0 521000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H12 compound treatment 4105920.0 -1378954.09836066 -1.52472381400571 -2.3828 -0.9922 2141965 PK04_098150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 4375920.0 -1340000.0 -1.47 3901840.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H13 compound treatment 5928040.0 443165.90163934 0.490013122690679 0.5112 0.4107 2142053 PK04_098151 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 6613680.0 897000.0 0.98 4447120.0 -585000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H14 compound treatment 5842240.0 357365.90163934 0.395143174954772 0.9383 0.9506 2143285 PK04_098152 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 6438760.0 722000.0 0.79 5469720.0 438000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H15 compound treatment 5502120.0 17245.9016393404 0.0190689718785876 -0.0076 -0.0284 2143953 PK04_098153 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 5874600.0 158000.0 0.17 4827480.0 -204000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H16 compound treatment 5628680.0 143805.90163934 0.159007673340783 0.0819 0.331 2142849 PK04_098154 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 5831200.0 114000.0 0.13 4889920.0 -142000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H17 compound treatment 4941240.0 -543634.09836066 -0.601101847306907 -0.9456 -0.9564 2142197 PK04_098155 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 5062200.0 -655000.0 -0.72 4713080.0 -319000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H18 compound treatment 3102840.0 -2382034.09836066 -2.6338397484455 -4.1749 -0.9978 2141678 PK04_098156 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 3634680.0 -2080000.0 -2.28 2722920.0 -2310000.0 -2.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H19 mock treatment 5633040.0 148165.90163934 0.163828570451838 0.1291 0.7546 5727760.0 10900.0 0.01 5079480.0 47800.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H20 mock treatment 5102400.0 -382474.09836066 -0.422905567853308 0.2071 0.2603 6323000.0 606000.0 0.66 5149240.0 118000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H21 compound treatment 5577840.0 92965.9016393404 0.102793359321045 0.3098 0.3568 2142657 PK04_098157 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 6435320.0 718000.0 0.79 4680040.0 -352000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H22 compound treatment 4215800.0 -1269074.09836066 -1.40322836112435 -2.1586 -0.9953 2141194 PK04_098158 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 4594800.0 -1120000.0 -1.23 3928920.0 -1100000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H23 compound treatment 3912440.0 -1572434.09836066 -1.73865665186053 -3.1363 -0.9996 2142665 PK04_098159 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 4049200.0 -1670000.0 -1.83 3171160.0 -1860000.0 -1.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 H24 compound treatment 5281720.0 -203154.09836066 -0.224629588505956 -0.6886 -0.9531 2141813 PK04_098160 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 5309760.0 -407000.0 -0.45 4511360.0 -520000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I01 compound treatment 3550440.0 -1934434.09836066 -2.13892379731972 -4.0228 -0.9561 2141395 PK04_098161 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 2729400.0 -2990000.0 -3.27 3480200.0 -1550000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I02 compound treatment 4905080.0 -579794.09836066 -0.641084333438963 -1.6573 -0.8908 2144813 PK04_098162 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 4213600.0 -1500000.0 -1.65 4450600.0 -581000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I03 compound treatment 4451920.0 -1032954.09836066 -1.14214803409168 -3.9539 -0.9302 2141107 PK04_098163 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 2663560.0 -3050000.0 -3.34 2677680.0 -2350000.0 -2.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I04 compound treatment 4559920.0 -924954.09836066 -1.02273131666187 -2.2232 -0.962 2142597 PK04_098164 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 4074480.0 -1640000.0 -1.8 4006120.0 -1030000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I05 mock treatment 5782920.0 298045.90163934 0.329552437196101 0.2038 0.2959 5337240.0 -380000.0 -0.42 5469320.0 438000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I06 mock treatment 5433360.0 -51514.0983606596 -0.0569596715517265 0.0515 0.3464 5842080.0 125000.0 0.14 5040800.0 9070.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I07 compound treatment 5368240.0 -116634.09836066 -0.128963529320517 0.0441 0.1804 2141144 PK04_098165 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 5906560.0 190000.0 0.21 5029400.0 -2330.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I08 compound treatment 5212200.0 -272674.09836066 -0.301498571799665 -0.7158 -0.7158 2142693 PK04_098166 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 4846400.0 -871000.0 -0.95 5046680.0 15000.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I09 compound treatment 5434320.0 -50554.0983606596 -0.0558981896190171 -0.0077 -0.0381 2141896 PK04_098167 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 5860400.0 143000.0 0.16 4917560.0 -114000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I10 compound treatment 5622800.0 137925.90163934 0.152506096502938 0.2272 0.8802 2141957 PK04_098168 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 5904200.0 187000.0 0.21 5067440.0 35700.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I11 compound treatment 3308920.0 -2175954.09836066 -2.40597496022387 -3.8824 -0.9922 2141394 PK04_098169 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4031400.0 -1690000.0 -1.85 2567760.0 -2460000.0 -2.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I12 compound treatment 5087120.0 -397754.09836066 -0.439800821948934 -0.1727 -0.3471 2142049 PK04_098170 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 5645120.0 -71800.0 -0.08 5250200.0 218000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I13 compound treatment 6038680.0 553805.90163934 0.612348915435443 0.5583 0.7526 2141346 PK04_098171 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 6095320.0 378000.0 0.41 4972200.0 -59500.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I14 compound treatment 3624360.0 -1860514.09836066 -2.05718968850109 -1.2658 -0.6119 2143477 PK04_098172 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 5782200.0 65300.0 0.07 4825720.0 -206000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I15 compound treatment 3024080.0 -2460794.09836066 -2.72092549534154 -4.2728 -0.9966 2141373 PK04_098173 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 3471360.0 -2250000.0 -2.46 2818960.0 -2210000.0 -2.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I16 compound treatment 4276080.0 -1208794.09836066 -1.33657614143296 -1.5375 -0.9299 2144645 PK04_098174 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 4943640.0 -773000.0 -0.85 4553760.0 -478000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I17 compound treatment 5386960.0 -97914.0983606596 -0.108264631632683 -0.0238 -0.0579 2141116 PK04_098175 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 6002080.0 285000.0 0.31 4787320.0 -244000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I18 compound treatment 5277920.0 -206954.09836066 -0.228831287822931 -0.5022 -0.6303 2142097 PK04_098176 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 5820760.0 104000.0 0.11 4279720.0 -752000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I19 compound treatment 5570680.0 85805.9016393404 0.0948764732395873 0.3013 0.6065 2141442 PK04_098177 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 5664600.0 -52300.0 -0.06 5514280.0 483000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I20 compound treatment 5445560.0 -39314.0983606596 -0.043470005323544 0.1389 0.2498 2142005 PK04_098178 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 6180200.0 463000.0 0.51 4809240.0 -222000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I21 mock treatment 5388640.0 -96234.0983606596 -0.106407038250442 0.055 0.2975 5841440.0 125000.0 0.14 5096800.0 65100.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I22 mock treatment 4699160.0 -785714.09836066 -0.868772208005139 -0.3589 -0.3218 6266800.0 550000.0 0.6 4677960.0 -354000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I23 compound treatment 4745240.0 -739634.09836066 -0.817821075235085 -1.3024 -0.9952 2141137 PK04_098179 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 4995960.0 -721000.0 -0.79 4385560.0 -646000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 I24 compound treatment 4164160.0 -1320714.09836066 -1.46032724342134 -2.5621 -0.9842 2144905 PK04_098180 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 4059920.0 -1660000.0 -1.81 3873200.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J01 compound treatment 4128600.0 -1356274.09836066 -1.49964630334545 -2.1948 -0.9914 2142853 PK04_098181 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 4628840.0 -1090000.0 -1.19 3925360.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J02 compound treatment 5086280.0 -398594.09836066 -0.440729618640054 -0.4731 -0.7975 2141434 PK04_098182 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 5733320.0 16400.0 0.02 4636520.0 -395000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J03 compound treatment 3193840.0 -2291034.09836066 -2.53322010690741 -4.0267 -0.9907 2142925 PK04_098183 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 3373120.0 -2340000.0 -2.57 3163840.0 -1870000.0 -1.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J04 compound treatment 5632080.0 147205.90163934 0.162767088519129 -0.1643 -0.4168 2141810 PK04_098184 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 5622400.0 -94500.0 -0.1 4689040.0 -343000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J05 mock treatment 5622080.0 137205.90163934 0.151709985053406 0.2873 0.9684 5828400.0 111000.0 0.12 5254680.0 223000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J06 mock treatment 5555760.0 70885.9016393404 0.078379274868728 0.1359 0.9799 5806400.0 89500.0 0.1 5090440.0 58700.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J07 compound treatment 5782600.0 297725.90163934 0.329198609885198 0.2976 0.7276 2143253 PK04_098185 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5670320.0 -46600.0 -0.05 5268080.0 236000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J08 compound treatment 4408160.0 -1076714.09836066 -1.19053391885769 -2.1375 -0.9928 2141219 PK04_098186 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4407640.0 -1310000.0 -1.43 3957680.0 -1070000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J09 compound treatment 5292320.0 -192554.09836066 -0.212909058832289 0.0646 0.0997 2142945 PK04_098187 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 6231760.0 515000.0 0.56 4793640.0 -238000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J10 compound treatment 5504680.0 19805.9016393404 0.0218995903658128 0.4268 0.6128 2141450 PK04_098188 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 6352160.0 635000.0 0.7 5053240.0 21500.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J11 compound treatment 5552040.0 67165.9016393404 0.0742660323794789 0.0703 0.3436 2144285 PK04_098189 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 5859760.0 143000.0 0.16 4923160.0 -109000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J12 compound treatment 3905560.0 -1579314.09836066 -1.74626393904495 -2.8248 -0.9606 2141139 PK04_098190 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 3760520.0 -1960000.0 -2.14 4031400.0 -1000000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J13 compound treatment 4778400.0 -706474.09836066 -0.781155720142747 -0.9704 -0.9039 2143473 PK04_098191 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 5066600.0 -650000.0 -0.71 4844920.0 -187000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J14 compound treatment 5075000.0 -409874.09836066 -0.45320203134939 -0.1765 -0.3069 2144013 PK04_098192 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 6002760.0 286000.0 0.31 4866800.0 -165000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J15 compound treatment 2879120.0 -2605754.09836066 -2.88120926718066 -3.269 -0.9371 2142837 PK04_098193 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 4442800.0 -1270000.0 -1.4 3651160.0 -1380000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J16 compound treatment 5194120.0 -290754.09836066 -0.321489814865693 -0.0336 -0.0881 2141784 PK04_098194 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 5893400.0 176000.0 0.19 5101440.0 69700.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J17 compound treatment 4233120.0 -1251754.09836066 -1.38407745792171 -1.5722 -0.9365 2144425 PK04_098195 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 5055240.0 -662000.0 -0.72 4419520.0 -612000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J18 compound treatment 4750240.0 -734634.09836066 -0.812292523502224 -1.8915 -0.9783 2141332 PK04_098196 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 4458200.0 -1260000.0 -1.38 3950240.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J19 compound treatment 4686920.0 -797954.09836066 -0.882306102647184 -0.6194 -0.6815 2143957 PK04_098197 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 5740600.0 23700.0 0.03 4816000.0 -216000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J20 compound treatment 4247000.0 -1237874.09836066 -1.36873019831129 -1.5612 -0.9383 2141933 PK04_098198 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 5145000.0 -572000.0 -0.63 4325200.0 -707000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J21 mock treatment 4669040.0 -815834.09836066 -0.902076203643898 -0.6781 -0.7071 5761720.0 44800.0 0.05 4711400.0 -320000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J22 mock treatment 4985280.0 -499594.09836066 -0.552406363643861 -0.5023 -0.5817 5975200.0 258000.0 0.28 4433360.0 -598000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J23 compound treatment 4449560.0 -1035314.09836066 -1.1447575105096 -2.1641 -0.9889 2144049 PK04_098199 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 4335240.0 -1380000.0 -1.51 3945160.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 J24 compound treatment 3454240.0 -2030634.09836066 -2.24529313265998 -2.958 -0.9751 2141196 PK04_098200 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 4313040.0 -1400000.0 -1.54 3695800.0 -1340000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K01 compound treatment 4564920.0 -919954.09836066 -1.01720276492901 -1.6827 -0.9955 2141522 PK04_098201 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 4947160.0 -770000.0 -0.84 3981200.0 -1050000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K02 compound treatment 5185840.0 -299034.09836066 -0.330645096535312 -1.1586 -0.8202 2142617 PK04_098202 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 4503560.0 -1210000.0 -1.33 4685560.0 -346000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K03 compound treatment 5419440.0 -65434.0983606596 -0.0723511595760135 -0.5345 -0.7551 2141439 PK04_098203 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 5092960.0 -624000.0 -0.68 4862120.0 -170000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K04 compound treatment 5334520.0 -150354.09836066 -0.166248082206937 -0.5252 -0.7308 2143329 PK04_098204 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 5079880.0 -637000.0 -0.7 4986120.0 -45600.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K05 compound treatment 3591440.0 -1893434.09836066 -2.09358967311025 -2.5275 -0.9468 2141725 PK04_098205 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 4436840.0 -1280000.0 -1.4 4152480.0 -879000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K06 compound treatment 5717080.0 232205.90163934 0.256752467977778 0.2446 0.6614 2142973 PK04_098206 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 5947080.0 230000.0 0.25 4946800.0 -84900.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K07 mock treatment 5608760.0 123885.90163934 0.136981923237062 0.1926 0.8993 5749760.0 32900.0 0.04 5191800.0 160000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K08 mock treatment 5492680.0 7805.90163934045 0.00863106620694473 0.2156 0.3895 5567240.0 -150000.0 -0.16 5558600.0 527000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K09 compound treatment 3549640.0 -1935234.09836066 -2.13980836559698 -4.3823 -0.9729 2141136 PK04_098207 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 2631440.0 -3090000.0 -3.38 2967440.0 -2060000.0 -2.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K10 compound treatment 5344600.0 -140274.09836066 -0.155102521913487 -0.3426 -0.7565 2143005 PK04_098208 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 5705040.0 -11900.0 -0.01 4607920.0 -424000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K11 compound treatment 1582320.0 -3902554.09836066 -4.31509444461567 -7.3663 -0.9961 2141925 PK04_098209 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1441680.0 -4280000.0 -4.68 1283400.0 -3750000.0 -3.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K12 compound treatment 4659040.0 -825834.09836066 -0.913133307109621 -1.8671 -0.991 2144741 PK04_098210 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 4560040.0 -1160000.0 -1.27 3981600.0 -1050000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K13 compound treatment 5613040.0 128165.90163934 0.141714363520392 0.2952 0.3332 2141147 PK04_098211 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 6424520.0 708000.0 0.77 4627800.0 -404000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K14 compound treatment 4804000.0 -680874.09836066 -0.752849535270495 -1.354 -0.9787 2143465 PK04_098212 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 5172040.0 -545000.0 -0.6 4039560.0 -992000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K15 mock treatment 5565000.0 80125.9016393404 0.0885960384710564 0.1704 0.7128 5919200.0 202000.0 0.22 5016800.0 -14900.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K16 mock treatment 5102440.0 -382434.09836066 -0.422861339439445 -0.3217 -0.5157 5945320.0 228000.0 0.25 4648560.0 -383000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K17 compound treatment 4692160.0 -792714.09836066 -0.876512180431145 -0.8359 -0.8488 2141530 PK04_098213 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 5582680.0 -134000.0 -0.15 4608880.0 -423000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K18 compound treatment 5259320.0 -225554.09836066 -0.249397500269177 0.1602 0.2011 2143169 PK04_098214 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 6382840.0 666000.0 0.73 4830120.0 -202000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K19 compound treatment 4670240.0 -814634.09836066 -0.900749351228011 -0.9919 -0.9068 2141707 PK04_098215 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 5489720.0 -227000.0 -0.25 4465200.0 -567000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K20 compound treatment 4876000.0 -608874.09836066 -0.673238390317286 -0.2306 -0.2411 2143073 PK04_098216 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 6262640.0 546000.0 0.6 4709040.0 -323000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K21 compound treatment 4828120.0 -656754.09836066 -0.72617980171117 -0.6857 -0.7079 2141428 PK04_098217 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 5862440.0 146000.0 0.16 4413080.0 -619000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K22 compound treatment 308840.0 -5176034.09836066 -5.72319445676862 -9.4338 -0.9958 2142725 PK04_098218 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 354880.0 -5360000.0 -5.87 304160.0 -4730000.0 -4.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K23 mock treatment 4987200.0 -497674.09836066 -0.550283399778442 -0.9602 -0.997 5256640.0 -460000.0 -0.5 4425040.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 K24 mock treatment 4803480.0 -681394.09836066 -0.753424504650712 -1.1968 -0.9566 4884200.0 -833000.0 -0.91 4625520.0 -406000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L01 compound treatment 4673840.0 -811034.09836066 -0.896768793980351 -1.4164 -0.993 2143889 PK04_098219 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5094920.0 -622000.0 -0.68 4159440.0 -872000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L02 compound treatment 3195320.0 -2289554.09836066 -2.53158365559449 -3.9259 -0.9958 2141700 PK04_098220 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 3668760.0 -2050000.0 -2.24 3013560.0 -2020000.0 -2.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L03 compound treatment 4482600.0 -1002274.09836066 -1.10822484065884 -1.9132 -0.9999 2142733 PK04_098221 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 4690760.0 -1030000.0 -1.12 3953800.0 -1080000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L04 compound treatment 5469840.0 -15034.0983606596 -0.0166233581087675 -0.1988 -0.6099 2141934 PK04_098222 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 5714920.0 -1990.0 0.0 4707440.0 -324000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L05 compound treatment 4889600.0 -595274.09836066 -0.658200729603902 -0.5205 -0.7233 2143873 PK04_098223 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 5757240.0 40300.0 0.04 4745280.0 -286000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L06 compound treatment 5615200.0 130325.90163934 0.144102697868988 -0.1659 -0.3787 2141797 PK04_098224 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 5339520.0 -377000.0 -0.41 5013600.0 -18100.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L07 mock treatment 2691200.0 -2793674.09836066 -3.08899435550854 -5.1021 -0.993 2715920.0 -3000000.0 -3.29 2578760.0 -2450000.0 -2.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L08 mock treatment 5592960.0 108085.90163934 0.119511699761219 -0.0795 -0.3633 5584240.0 -133000.0 -0.15 4920160.0 -112000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L09 compound treatment 5178040.0 -306834.09836066 -0.339269637238577 -0.0048 -0.009 2142957 PK04_098225 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 5645920.0 -71000.0 -0.08 5438920.0 407000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L10 compound treatment 4697720.0 -787154.09836066 -0.870364430904203 -0.746 -0.8105 3413983 PK04_098226 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 5541040.0 -176000.0 -0.19 4803360.0 -228000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L11 compound treatment 1181680.0 -4303194.09836066 -4.75808623786642 -7.6801 -0.9955 2142717 PK04_098227 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1416440.0 -4300000.0 -4.71 1210760.0 -3820000.0 -3.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L12 compound treatment 4890160.0 -594714.09836066 -0.657581531809822 -0.6903 -0.8192 3413985 PK04_098228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 5235760.0 -481000.0 -0.53 5020560.0 -11200.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L13 compound treatment 5029680.0 -455194.09836066 -0.503312824256049 -0.3261 -0.5609 2143357 PK04_098229 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 5874680.0 158000.0 0.17 4798240.0 -233000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L14 compound treatment 3598880.0 -1885994.09836066 -2.08536318813175 -3.0833 -0.9927 3413987 PK04_098230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 4226120.0 -1490000.0 -1.63 3415000.0 -1620000.0 -1.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L15 mock treatment 5649960.0 165085.90163934 0.182537189515842 0.1078 0.2663 5952280.0 235000.0 0.26 4779120.0 -253000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L16 mock treatment 5330680.0 -154194.09836066 -0.170494009937774 -0.7239 -0.8513 5010880.0 -706000.0 -0.77 4722720.0 -309000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L17 compound treatment 5524560.0 39685.9016393404 0.0438811120556709 0.0956 0.2321 2143089 PK04_098231 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 6031200.0 314000.0 0.34 4810120.0 -222000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L18 compound treatment 4533080.0 -951794.09836066 -1.05240858236387 -1.2657 -0.9384 3413990 PK04_098232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 5357080.0 -360000.0 -0.39 4288640.0 -743000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L19 compound treatment 4564600.0 -920274.09836066 -1.01755659223991 -1.0369 -0.8335 2144137 PK04_098233 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 5656920.0 -60000.0 -0.07 4321480.0 -710000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L20 compound treatment 4926920.0 -557954.09836066 -0.616935619469823 -0.2996 -0.4544 3413992 PK04_098234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 5905000.0 188000.0 0.21 4924200.0 -108000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L21 compound treatment 4782080.0 -702794.09836066 -0.77708670606736 -0.7818 -0.8782 2143369 PK04_098235 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 5357480.0 -359000.0 -0.39 4849040.0 -183000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L22 compound treatment 3663080.0 -1821794.09836066 -2.01437658388181 -2.3569 -0.9457 3413998 PK04_098236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5cccc(Br)c5)C/C=C/C[C@@H](Cc6cccc(Br)c6)C(=O)O[C@@H]14 4852800.0 -864000.0 -0.95 3914120.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L23 mock treatment 3371120.0 -2113754.09836066 -2.33719977666707 -1.7566 -0.7169 5743840.0 26900.0 0.03 4299520.0 -732000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 L24 mock treatment 4551560.0 -933314.09836066 -1.03197505515922 -1.4363 -0.9771 5174920.0 -542000.0 -0.59 4172600.0 -859000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M01 compound treatment 4344000.0 -1140874.09836066 -1.26147629469377 -2.2117 -0.9739 2141977 PK04_098237 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 4211240.0 -1510000.0 -1.65 4114640.0 -917000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M02 compound treatment 4547960.0 -936914.09836066 -1.03595561240688 -1.6368 -0.9738 2144277 PK04_098238 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 4659280.0 -1060000.0 -1.16 4393160.0 -639000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M03 compound treatment 4698440.0 -786434.09836066 -0.869568319454671 -1.7594 -0.955 2143353 PK04_098239 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 4389080.0 -1330000.0 -1.45 4310640.0 -721000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M04 compound treatment 4094200.0 -1390674.09836066 -1.53768273926754 -3.2815 -0.9768 2142753 PK04_098240 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 3454960.0 -2260000.0 -2.48 3368680.0 -1660000.0 -1.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M05 compound treatment 4584840.0 -900034.09836066 -0.995177014825289 -0.9415 -0.839 2142713 PK04_098241 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 5259680.0 -457000.0 -0.5 4897440.0 -134000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M06 compound treatment 5350720.0 -134154.09836066 -0.148335574592465 -0.1923 -0.6242 2143893 PK04_098242 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5785160.0 68300.0 0.07 4773120.0 -259000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M07 compound treatment 5272360.0 -212514.09836066 -0.234979037349873 -0.4912 -0.9257 2143173 PK04_098243 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 5312000.0 -405000.0 -0.44 4860040.0 -172000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M08 compound treatment 4520040.0 -964834.09836066 -1.06682704528318 -1.2209 -0.928 2143913 PK04_098244 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 5373760.0 -343000.0 -0.38 4362160.0 -670000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M09 mock treatment 4758720.0 -726154.09836066 -0.80291609976329 -0.8623 -0.8458 5656800.0 -60100.0 -0.07 4409080.0 -623000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M10 mock treatment 5438760.0 -46114.0983606596 -0.0509888356802359 -0.1805 -0.3722 5885000.0 168000.0 0.18 4587560.0 -444000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M11 compound treatment 3174120.0 -2310754.09836066 -2.55502471494182 -3.466 -0.9811 2143965 PK04_098245 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 4195320.0 -1520000.0 -1.67 3256200.0 -1780000.0 -1.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M12 compound treatment 5620160.0 135285.90163934 0.149587021187987 -0.0841 -0.2314 2144453 PK04_098246 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 5748040.0 31100.0 0.03 4703600.0 -328000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M13 mock treatment 5564840.0 79965.9016393404 0.0884191248156048 -0.0011 -0.0018 6065240.0 348000.0 0.38 4561600.0 -470000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M14 mock treatment 5380680.0 -104194.09836066 -0.115208492609157 -0.7218 -0.5424 5880120.0 163000.0 0.18 3722720.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M15 compound treatment 4816200.0 -668674.09836066 -0.739359869042312 -0.8192 -0.9063 2142065 PK04_098247 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 5534880.0 -182000.0 -0.2 4553200.0 -479000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M16 compound treatment 5222480.0 -262394.09836066 -0.290131869436902 -0.0254 -0.0564 2143293 PK04_098248 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 6020920.0 304000.0 0.33 4945280.0 -86400.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M17 compound treatment 4609360.0 -875514.09836066 -0.968064997127335 -0.942 -0.8301 2142857 PK04_098249 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 5647160.0 -69700.0 -0.08 4446680.0 -585000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M18 compound treatment 5264680.0 -220194.09836066 -0.243470892811549 -0.4932 -0.6795 2142613 PK04_098250 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 5780320.0 63400.0 0.07 4353960.0 -678000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M19 compound treatment 4733760.0 -751114.09836066 -0.830514630013736 -0.7358 -0.8276 2142697 PK04_098251 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 5544840.0 -172000.0 -0.19 4777080.0 -255000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M20 compound treatment 4623560.0 -861314.09836066 -0.952363910206008 -0.9488 -0.7716 2144821 PK04_098252 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 5792240.0 75300.0 0.08 4261040.0 -771000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M21 compound treatment 4746960.0 -737914.09836066 -0.815919253438981 -1.2222 -0.9928 2142965 PK04_098253 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 5160320.0 -557000.0 -0.61 4342680.0 -689000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M22 compound treatment 4364640.0 -1120234.09836066 -1.23865443314052 -1.385 -0.915 2144777 PK04_098254 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 5373920.0 -343000.0 -0.38 4249960.0 -782000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M23 compound treatment 4214920.0 -1269954.09836066 -1.40420138622933 -1.6058 -0.9397 2141143 PK04_098255 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 5091000.0 -626000.0 -0.69 4342480.0 -689000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 M24 compound treatment 3254440.0 -2230434.09836066 -2.46621405990513 -3.6692 -0.9933 2144937 PK04_098256 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 3935680.0 -1780000.0 -1.95 3100240.0 -1930000.0 -1.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N01 compound treatment 4175040.0 -1309834.09836066 -1.44829711485063 -2.93 -0.9939 2144901 PK04_098257 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 4147000.0 -1570000.0 -1.72 3131240.0 -1900000.0 -1.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N02 compound treatment 4070160.0 -1414714.09836066 -1.56426401599914 -2.4115 -0.9884 3413999 PK04_098258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 4327160.0 -1390000.0 -1.52 3945000.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N03 compound treatment 6326600.0 841725.90163934 0.930705038420551 0.3556 0.3463 2143297 PK04_098259 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 5813760.0 96900.0 0.11 4612360.0 -419000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N04 compound treatment 4074160.0 -1410714.09836066 -1.55984117461285 -2.927 -0.9955 3414005 PK04_098260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 3967920.0 -1750000.0 -1.92 3442880.0 -1590000.0 -1.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N05 compound treatment 5204360.0 -280514.09836066 -0.310167340916792 0.0281 0.0324 2142017 PK04_098261 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 5385440.0 -331000.0 -0.36 5750920.0 719000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N06 compound treatment 5572600.0 87725.9016393404 0.0969994371050062 0.2487 0.6772 3188747 PK04_098262 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)CCc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 5698720.0 -18200.0 -0.02 5384080.0 352000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N07 compound treatment 5698200.0 213325.90163934 0.235876656634492 -0.2726 -0.4594 2143017 PK04_098263 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 5531720.0 -185000.0 -0.2 4528360.0 -503000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N08 compound treatment 3631000.0 -1853874.09836066 -2.04984777179985 -3.5028 -0.9862 3188748 PK04_098264 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 3504240.0 -2210000.0 -2.42 3443360.0 -1590000.0 -1.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N09 mock treatment 5034720.0 -450154.09836066 -0.497740044109324 -0.6957 -0.9114 5582040.0 -135000.0 -0.15 4474200.0 -558000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N10 mock treatment 6205760.0 720885.90163934 0.797091000140749 0.3565 0.3993 5388720.0 -328000.0 -0.36 5210800.0 179000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N11 compound treatment 4860360.0 -624514.09836066 -0.690531700137678 -0.6184 -0.832 2144265 PK04_098265 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 5580080.0 -137000.0 -0.15 4801760.0 -230000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N12 compound treatment 3027440.0 -2457434.09836066 -2.71721030857705 -3.0177 -0.9218 3069249 PK04_098266 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3c(OC)cccc3OC)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 4849120.0 -868000.0 -0.95 3477960.0 -1550000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N13 mock treatment 5477760.0 -7114.09836065955 -0.0078661321639146 -0.3665 -0.8178 5388680.0 -328000.0 -0.36 4765280.0 -266000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N14 mock treatment 4924160.0 -560714.09836066 -0.619987380026362 0.1675 0.1812 6285240.0 568000.0 0.62 5318400.0 287000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N15 compound treatment 4351840.0 -1133034.09836066 -1.25280752557664 -1.1118 -0.8285 2143165 PK04_098267 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 5454000.0 -263000.0 -0.29 4648120.0 -384000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N16 compound treatment 3904080.0 -1580794.09836066 -1.74790039035788 -1.9592 -0.9189 3188751 PK04_098268 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 5204720.0 -512000.0 -0.56 3950920.0 -1080000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N17 compound treatment 4551200.0 -933674.09836066 -1.03237311088398 -1.3668 -0.977 2144365 PK04_098269 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 5098840.0 -618000.0 -0.68 4375920.0 -656000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N18 compound treatment 1562160.0 -3922714.09836066 -4.33738556520257 -6.3735 -0.9919 3188752 PK04_098270 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3cccc(F)c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 2568840.0 -3150000.0 -3.45 1789000.0 -3240000.0 -3.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N19 compound treatment 2831320.0 -2653554.09836066 -2.93406222174682 -3.759 -0.9699 2142105 PK04_098271 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 4001040.0 -1720000.0 -1.88 3340200.0 -1690000.0 -1.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N20 compound treatment 4151400.0 -1333474.09836066 -1.4744361074436 -2.424 -0.9968 3068687 PK04_098272 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(OC)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 4584240.0 -1130000.0 -1.24 3553440.0 -1480000.0 -1.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N21 compound treatment 4807520.0 -677354.09836066 -0.74895743485056 -0.6293 -0.7754 2144245 PK04_098273 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 5432920.0 -284000.0 -0.31 5001840.0 -29900.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N22 compound treatment 1818360.0 -3666514.09836066 -4.05410257441074 -6.0402 -0.993 3068689 PK04_098274 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 2909680.0 -2810000.0 -3.07 1710040.0 -3320000.0 -3.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N23 compound treatment 4880720.0 -604154.09836066 -0.668019437481465 -1.3068 -0.9695 2143153 PK04_098275 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 4786480.0 -930000.0 -1.02 4457320.0 -574000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 N24 compound treatment 313640.0 -5171234.09836066 -5.71788704710507 -8.6766 -0.995 3188876 PK04_098276 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1538640.0 -4180000.0 -4.58 313920.0 -4720000.0 -4.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O01 compound treatment 3801680.0 -1683194.09836066 -1.86112512984688 -3.1466 -0.9959 2143373 PK04_098277 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 3896560.0 -1820000.0 -1.99 3441960.0 -1590000.0 -1.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O02 compound treatment 4350040.0 -1134834.09836066 -1.25479780420047 -2.3882 -0.987 2142209 PK04_098278 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 4170360.0 -1550000.0 -1.69 3848000.0 -1180000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O03 compound treatment 4457400.0 -1027474.09836066 -1.13608874139247 -1.2383 -0.9181 2144345 PK04_098279 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 5165720.0 -551000.0 -0.6 4628000.0 -404000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O04 compound treatment 4631520.0 -853354.09836066 -0.943562455847292 -1.9502 -0.9927 2142673 PK04_098280 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 4655600.0 -1060000.0 -1.16 3764240.0 -1270000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O05 compound treatment 3601360.0 -1883514.09836066 -2.08262102647225 -2.1248 -0.8968 2143977 PK04_098281 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 4971120.0 -746000.0 -0.82 4253520.0 -778000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O06 compound treatment 4258840.0 -1226034.09836066 -1.35563858780787 -1.9709 -0.9909 2142077 PK04_098282 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 4767040.0 -950000.0 -1.04 4017520.0 -1010000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O07 compound treatment 5574720.0 89845.9016393404 0.0993435430397395 -1.013 -0.7284 2141985 PK04_098283 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 4577720.0 -1140000.0 -1.25 4427600.0 -604000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O08 compound treatment 3057280.0 -2427594.09836066 -2.68421591183533 -3.8145 -0.9826 2143485 PK04_098284 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 3657840.0 -2060000.0 -2.25 3369840.0 -1660000.0 -1.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O09 compound treatment 5088760.0 -396114.09836066 -0.437987456980555 -1.1497 -0.9508 2144665 PK04_098285 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 5170800.0 -546000.0 -0.6 4079760.0 -952000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O10 compound treatment 5671880.0 187005.90163934 0.206774360312708 0.0801 0.2645 2143273 PK04_098286 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 5825120.0 108000.0 0.12 4845800.0 -186000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O11 mock treatment 4932040.0 -552834.09836066 -0.611274382495372 -0.9114 -0.956 5442800.0 -274000.0 -0.3 4367000.0 -665000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O12 mock treatment 5249480.0 -235394.09836066 -0.260277690079448 -0.3965 -0.3814 6142200.0 425000.0 0.47 4142640.0 -889000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O13 compound treatment 4918800.0 -566074.09836066 -0.62591398748399 -0.6965 -0.7387 2144773 PK04_098287 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 5822160.0 105000.0 0.12 4338440.0 -693000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O14 compound treatment 4376840.0 -1108034.09836066 -1.22516476691234 -1.2469 -0.8142 2143945 PK04_098288 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 5702360.0 -14500.0 -0.02 4116360.0 -915000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O15 compound treatment 5023800.0 -461074.09836066 -0.509814401093894 -0.6906 -0.9734 2144317 PK04_098289 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 5346320.0 -371000.0 -0.41 4752240.0 -279000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O16 compound treatment 5357920.0 -126954.09836066 -0.140374460097144 -0.1177 -0.2631 2143905 PK04_098290 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 5960680.0 244000.0 0.27 4702480.0 -329000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O17 compound treatment 5005120.0 -479754.09836066 -0.530469070367866 -0.967 -0.9994 2143917 PK04_098291 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 5193640.0 -523000.0 -0.57 4462400.0 -569000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O18 compound treatment 4771080.0 -713794.09836066 -0.789249519879656 -1.0604 -0.9628 2144253 PK04_098292 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 5107240.0 -610000.0 -0.67 4653400.0 -378000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O19 compound treatment 3550160.0 -1934714.09836066 -2.13923339621676 -3.2669 -0.9949 2144105 PK04_098293 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 4185880.0 -1530000.0 -1.68 3195800.0 -1840000.0 -1.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O20 compound treatment 4731200.0 -753674.09836066 -0.833345248500961 -1.3145 -0.9974 2144293 PK04_098294 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 5041400.0 -676000.0 -0.74 4330600.0 -701000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O21 compound treatment 4629280.0 -855594.09836066 -0.946039247023614 -1.2985 -0.9829 2142997 PK04_098295 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 5145640.0 -571000.0 -0.63 4356760.0 -675000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O22 compound treatment 3556240.0 -1928634.09836066 -2.1325106773096 -3.4289 -0.9945 2144737 PK04_098296 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 3780680.0 -1940000.0 -2.12 3351640.0 -1680000.0 -1.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O23 compound treatment 3850280.0 -1634594.09836066 -1.80738760700347 -2.5134 -0.9646 2141452 PK04_098297 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 4212040.0 -1500000.0 -1.65 4137040.0 -895000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 O24 compound treatment 3550360.0 -1934514.09836066 -2.13901225414744 -2.842 -0.9775 2142677 PK04_098298 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 4404880.0 -1310000.0 -1.44 3689920.0 -1340000.0 -1.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P01 compound treatment 1788240.0 -3696634.09836066 -4.0874065700495 -7.213 -0.9996 2144005 PK04_098299 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1768600.0 -3950000.0 -4.32 964360.0 -4070000.0 -4.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P02 compound treatment 1142200.0 -4342674.09836066 -4.80173968234909 -7.8419 -0.9947 3068772 PK04_098300 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(C#N)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1233480.0 -4480000.0 -4.91 1174600.0 -3860000.0 -3.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P03 compound treatment 4491600.0 -993274.09836066 -1.09827344753969 -1.8187 -0.9776 2142593 PK04_098301 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 5029920.0 -687000.0 -0.75 3736840.0 -1290000.0 -1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P04 compound treatment 3625480.0 -1859394.09836066 -2.05595129291293 -4.1137 -0.9876 3000699 PK04_098302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 3064080.0 -2650000.0 -2.91 2875360.0 -2160000.0 -2.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P05 compound treatment 4306920.0 -1177954.09836066 -1.30247603434467 -2.1727 -0.9979 2144921 PK04_098303 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 4509960.0 -1210000.0 -1.32 3896760.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P06 compound treatment 2953720.0 -2531154.09836066 -2.79872327532636 -4.7984 -0.9793 3000700 PK04_098304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 3839400.0 -1880000.0 -2.06 1587760.0 -3440000.0 -3.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P07 compound treatment 4432960.0 -1051914.09836066 -1.1631123022627 -0.9883 -0.5785 2143937 PK04_098305 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 6234600.0 518000.0 0.57 3920080.0 -1110000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P08 compound treatment 3873680.0 -1611194.09836066 -1.78151398489367 -2.8682 -0.9471 3000701 PK04_098306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 4881680.0 -835000.0 -0.91 2768120.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P09 compound treatment 4864160.0 -620714.09836066 -0.686330000820703 -1.487 -0.9753 2144785 PK04_098307 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 4684840.0 -1030000.0 -1.13 4275440.0 -756000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P10 compound treatment 4003760.0 -1481114.09836066 -1.63768318301154 -2.4302 -0.9351 3089322 PK04_098308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 5107560.0 -609000.0 -0.67 3134280.0 -1900000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P11 mock treatment 4603480.0 -881394.09836066 -0.97456657396518 -1.0556 -0.8916 5518040.0 -199000.0 -0.22 4398080.0 -634000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P12 mock treatment 4471640.0 -1013234.09836066 -1.12034342605728 -1.7511 -0.9968 4871840.0 -845000.0 -0.93 4048120.0 -984000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P13 compound treatment 2762440.0 -2722434.09836066 -3.01022355041872 -4.7604 -0.9977 2144213 PK04_098309 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 3289280.0 -2430000.0 -2.66 2464360.0 -2570000.0 -2.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P14 compound treatment 4668080.0 -816794.09836066 -0.903137685576607 -3.7036 -0.9232 3089323 PK04_098310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 3009840.0 -2710000.0 -2.96 2493680.0 -2540000.0 -2.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P15 compound treatment 4408920.0 -1075954.09836066 -1.1896935789943 -1.2321 -0.8715 2144225 PK04_098311 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 5525240.0 -192000.0 -0.21 4299880.0 -732000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P16 compound treatment 3170680.0 -2314194.09836066 -2.55882835853403 -3.6001 -0.9869 3000703 PK04_098312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 4022760.0 -1690000.0 -1.86 3216720.0 -1820000.0 -1.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P17 compound treatment 4257760.0 -1227114.09836066 -1.35683275498217 -2.1319 -0.9961 2141953 PK04_098313 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 4580840.0 -1140000.0 -1.24 3943960.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P18 compound treatment 3709280.0 -1775594.09836066 -1.96329276587017 -3.9463 -0.9952 3000704 PK04_098314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)c4cc5ccccc5[nH]4)[C@H]1OC(=O)c6cc7ccccc7[nH]6 3527880.0 -2190000.0 -2.4 2565880.0 -2470000.0 -2.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P19 compound treatment 4211600.0 -1273274.09836066 -1.40787234457995 -2.1324 -0.9944 2143337 PK04_098315 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 4715480.0 -1000000.0 -1.1 3847160.0 -1180000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P20 compound treatment 1426120.0 -4058754.09836066 -4.48780640075027 -7.2252 -0.9913 3089326 PK04_098316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1484560.0 -4230000.0 -4.63 1652120.0 -3380000.0 -3.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P21 compound treatment 4143280.0 -1341594.09836066 -1.48341447545777 -2.1593 -0.991 2143233 PK04_098317 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 4704360.0 -1010000.0 -1.11 3888080.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P22 compound treatment 3247440.0 -2237434.09836066 -2.47395403233114 -4.0356 -0.999 3089328 PK04_098318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 3666240.0 -2050000.0 -2.25 2769560.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P23 compound treatment 3831880.0 -1652994.09836066 -1.8277326773804 -2.8359 -0.9958 2142969 PK04_098319 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 4232600.0 -1480000.0 -1.63 3578280.0 -1450000.0 -1.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2098 P24 compound treatment 3456680.0 -2028194.09836066 -2.24259519941434 -3.459 -0.9927 3189006 PK04_098320 CC(C)[Si](OCCCNS(=O)(=O)c1ccc(Br)cc1)(C(C)C)C(C)C 3815360.0 -1900000.0 -2.08 3371560.0 -1660000.0 -1.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A01 compound treatment 2177560.0 -2464592.5 -2.72512542733459 -5.1044 -0.9916 3188092 PK04_102001 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 2165200.0 -3190000.0 -3.49 2575600.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A02 compound treatment 951840.0 -3690312.5 -4.08041671333524 -7.3513 -0.9991 3188093 PK04_102002 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 1243400.0 -4110000.0 -4.5 1054080.0 -4140000.0 -4.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A03 compound treatment 2217400.0 -2424752.5 -2.68107392712715 -5.0671 -0.9771 3069304 PK04_102003 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccccc43 1880920.0 -3470000.0 -3.8 2906240.0 -2290000.0 -2.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A04 compound treatment 1295280.0 -3346872.5 -3.70067155190844 -6.7133 -0.9988 3188094 PK04_102004 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1572200.0 -3780000.0 -4.14 1418000.0 -3780000.0 -3.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A05 compound treatment 3205880.0 -1436272.5 -1.58810136374732 -2.824 -0.9696 3069305 PK04_102005 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 3383280.0 -1970000.0 -2.15 4049200.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A06 compound treatment 1838880.0 -2803272.5 -3.09960740751171 -5.8396 -0.994 3188095 PK04_102006 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1792080.0 -3560000.0 -3.9 2087080.0 -3110000.0 -3.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A07 compound treatment 444680.0 -4197472.5 -4.64118877270287 -8.7152 -0.9968 3069306 PK04_102007 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 251360.0 -5100000.0 -5.58 341440.0 -4850000.0 -4.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A08 compound treatment 988240.0 -3653912.5 -4.04016885672001 -7.3516 -0.9994 3188096 PK04_102008 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1335640.0 -4010000.0 -4.4 912760.0 -4280000.0 -4.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A09 compound treatment 1796160.0 -2845992.5 -3.14684335351728 -6.0019 -0.9933 3188097 PK04_102009 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1665480.0 -3680000.0 -4.04 1992080.0 -3200000.0 -3.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A10 compound treatment 2096640.0 -2545512.5 -2.81459950857922 -5.4211 -0.9952 3069307 PK04_102010 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 2110680.0 -3240000.0 -3.55 2177720.0 -3020000.0 -3.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A11 compound treatment 2449960.0 -2192192.5 -2.42392992892829 -4.9119 -0.9856 3188098 PK04_102011 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 2135720.0 -3210000.0 -3.52 2639920.0 -2550000.0 -2.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A12 compound treatment 1483960.0 -3158192.5 -3.49204612371717 -6.3464 -0.9989 3069308 PK04_102012 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1787200.0 -3560000.0 -3.9 1608800.0 -3590000.0 -3.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A13 mock treatment 4210560.0 -431592.5 -0.477216292753023 -1.1912 -0.7718 4014680.0 -1340000.0 -1.46 5071280.0 -123000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A14 mock treatment 4326080.0 -316072.5 -0.349484633516986 -0.8736 -0.7533 4342000.0 -1010000.0 -1.1 5134880.0 -59300.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A15 compound treatment 172000.0 -4470152.5 -4.94269387000621 -9.0257 -0.998 3188099 PK04_102013 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 172720.0 -5180000.0 -5.67 191760.0 -5000000.0 -5.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A16 compound treatment 893320.0 -3748832.5 -4.14512288281665 -7.396 -0.9995 3188100 PK04_102014 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1279000.0 -4070000.0 -4.46 1002640.0 -4190000.0 -4.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A17 compound treatment 1797280.0 -2844872.5 -3.14560495792912 -6.1644 -0.9927 3069309 PK04_102015 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@]5(O[C@H](CCO)[C@H]([C@@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1556560.0 -3790000.0 -4.15 1829400.0 -3360000.0 -3.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A18 compound treatment 761920.0 -3880232.5 -4.29041322235626 -8.1967 -0.9971 3188101 PK04_102016 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 618120.0 -4730000.0 -5.18 486560.0 -4710000.0 -4.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A19 compound treatment 132400.0 -4509752.5 -4.98647999973048 -9.0923 -0.9981 3069310 PK04_102017 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 139400.0 -5210000.0 -5.71 156960.0 -5040000.0 -5.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A20 compound treatment 1637560.0 -3004592.5 -3.32220901448365 -6.0747 -0.9968 3188102 PK04_102018 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@@]5(O[C@@H](CCO)[C@@H]([C@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1787520.0 -3560000.0 -3.9 1908040.0 -3290000.0 -3.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A21 compound treatment 2575640.0 -2066512.5 -2.28496425257107 -4.3782 -0.9847 3188103 PK04_102019 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 2470000.0 -2880000.0 -3.15 3057800.0 -2140000.0 -2.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A22 compound treatment 104480.0 -4537672.5 -5.01735143260678 -9.0749 -0.9988 3069311 PK04_102020 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 230680.0 -5120000.0 -5.61 118120.0 -5080000.0 -5.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A23 compound treatment 2290200.0 -2351952.5 -2.60057821389668 -5.156 -0.9883 3188104 PK04_102021 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 2042600.0 -3310000.0 -3.62 2496240.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 A24 compound treatment 3933880.0 -708272.5 -0.783144231442658 -1.8051 -0.9673 3188105 PK04_102022 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 4053320.0 -1300000.0 -1.42 4274320.0 -920000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B01 compound treatment 2409520.0 -2232632.5 -2.46864485534367 -4.9662 -0.971 3069350 PK04_102023 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 1825600.0 -3520000.0 -3.86 2929160.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B02 compound treatment 2236080.0 -2406072.5 -2.66041925785318 -5.3337 -0.9896 3188106 PK04_102024 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1971440.0 -3380000.0 -3.7 2326840.0 -2870000.0 -2.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B03 compound treatment 4532920.0 -109232.5 -0.120779505431963 -0.7546 -0.7805 3069351 PK04_102025 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCCCC6=O)c7ccccc73 4508280.0 -842000.0 -0.92 4931040.0 -263000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B04 compound treatment 2896080.0 -1746072.5 -1.93065042911543 -3.4844 -0.9839 3188107 PK04_102026 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 3073240.0 -2280000.0 -2.49 3589080.0 -1610000.0 -1.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B05 compound treatment 2251920.0 -2390232.5 -2.64290480596347 -4.0032 -0.9913 3188221 PK04_102027 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 3170280.0 -2180000.0 -2.39 3297480.0 -1900000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B06 compound treatment 2568200.0 -2073952.5 -2.29319073754957 -3.8798 -0.9993 3069352 PK04_102028 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 3248040.0 -2100000.0 -2.3 3077080.0 -2120000.0 -2.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B07 compound treatment 2002720.0 -2639432.5 -2.9184478243293 -5.4474 -0.9944 3188222 PK04_102029 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 2046880.0 -3300000.0 -3.62 2305320.0 -2890000.0 -2.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B08 compound treatment 2059200.0 -2582952.5 -2.85599730395489 -4.4387 -0.9862 3069353 PK04_102030 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 2723480.0 -2630000.0 -2.88 3245680.0 -1950000.0 -1.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B09 compound treatment 2344320.0 -2297832.5 -2.54073716994019 -4.3959 -0.9983 3188223 PK04_102031 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 2868520.0 -2480000.0 -2.72 2847160.0 -2350000.0 -2.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B10 compound treatment 3251240.0 -1390912.5 -1.5379463424268 -2.5626 -0.963 3188224 PK04_102032 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 3564960.0 -1790000.0 -1.96 4252040.0 -942000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B11 compound treatment 3433000.0 -1209152.5 -1.33697242983381 -2.2197 -0.9506 3069354 PK04_102033 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 3739280.0 -1610000.0 -1.76 4453400.0 -741000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B12 compound treatment 2834760.0 -1807392.5 -1.99845258756725 -3.381 -0.9956 3188225 PK04_102034 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 3387600.0 -1960000.0 -2.15 3491960.0 -1700000.0 -1.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B13 mock treatment 4980240.0 338087.5 0.373826846796776 0.2172 0.2736 4899280.0 -451000.0 -0.49 5688640.0 494000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B14 mock treatment 5079680.0 437527.5 0.48377868365993 0.1226 0.1538 4836560.0 -514000.0 -0.56 5484280.0 290000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B15 compound treatment 2046160.0 -2595992.5 -2.8704157668742 -5.4341 -0.9951 3188226 PK04_102035 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 2086720.0 -3260000.0 -3.57 2237080.0 -2960000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B16 compound treatment 2466760.0 -2175392.5 -2.40535399510587 -4.3505 -0.9897 3069355 PK04_102036 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(I)c5)c6ccccc63 2611320.0 -2740000.0 -3.0 3071320.0 -2120000.0 -2.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B17 compound treatment 3494720.0 -1147432.5 -1.26872798724337 -2.6828 -0.9697 3188227 PK04_102037 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 3432320.0 -1920000.0 -2.1 3921120.0 -1270000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B18 compound treatment 1968800.0 -2673352.5 -2.95595351928503 -5.5776 -0.9939 3069356 PK04_102038 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1946680.0 -3400000.0 -3.73 2227440.0 -2970000.0 -2.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B19 compound treatment 3836800.0 -805352.5 -0.890486591887901 -1.8094 -0.9685 3188228 PK04_102039 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 4051640.0 -1300000.0 -1.42 4375760.0 -818000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B20 compound treatment 2214480.0 -2427672.5 -2.68430260133914 -5.5097 -0.9936 3188229 PK04_102040 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 2116160.0 -3230000.0 -3.54 1888880.0 -3310000.0 -3.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B21 compound treatment 4482400.0 -159752.5 -0.176639992140798 -0.4448 -0.5715 3069357 PK04_102041 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 4671760.0 -679000.0 -0.74 5342920.0 149000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B22 compound treatment 2243840.0 -2398312.5 -2.65183894556378 -5.3242 -0.9913 3188230 PK04_102042 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(I)c6)c7ccccc73 2040440.0 -3310000.0 -3.62 2259400.0 -2930000.0 -2.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B23 compound treatment 2922760.0 -1719392.5 -1.90115007706888 -3.5128 -0.986 3069358 PK04_102043 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 3069560.0 -2280000.0 -2.5 3514560.0 -1680000.0 -1.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 B24 compound treatment 4300520.0 -341632.5 -0.377746589975375 -1.7119 -0.8652 3188231 PK04_102044 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 3748080.0 -1600000.0 -1.75 4364400.0 -830000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C01 compound treatment 4159440.0 -482712.5 -0.533740205669801 -1.4815 -0.9459 3188232 PK04_102045 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 4215120.0 -1140000.0 -1.24 4407800.0 -786000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C02 compound treatment 2035280.0 -2606872.5 -2.8824458954449 -5.3487 -0.9971 3069359 PK04_102046 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 2230640.0 -3120000.0 -3.42 2239280.0 -2950000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C03 compound treatment 3456480.0 -1185672.5 -1.31101035089629 -2.2637 -0.9705 3188233 PK04_102047 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 3795320.0 -1550000.0 -1.7 4290360.0 -904000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C04 compound treatment 4401200.0 -240952.5 -0.266423672282472 -0.6424 -0.7599 3188234 PK04_102048 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 4618880.0 -731000.0 -0.8 5149120.0 -45000.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C05 compound treatment 4910040.0 267887.5 0.296205980467398 0.1643 0.2551 3069360 PK04_102049 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 4975880.0 -374000.0 -0.41 5591040.0 397000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C06 compound treatment 338000.0 -4304152.5 -4.75914595247521 -8.4209 -0.9988 3188235 PK04_102050 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 606440.0 -4740000.0 -5.2 579440.0 -4610000.0 -4.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C07 compound treatment 3063280.0 -1578872.5 -1.74577565916854 -2.2928 -0.9728 3069393 PK04_102051 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 4220520.0 -1130000.0 -1.24 4209400.0 -985000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C08 compound treatment 1926760.0 -2715392.5 -3.00243758225493 -5.2499 -0.9956 3188236 PK04_102052 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 2250640.0 -3100000.0 -3.39 2507640.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C09 compound treatment 74960.0 -4567192.5 -5.04999200203759 -9.1861 -0.9983 3069394 PK04_102053 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 109840.0 -5240000.0 -5.74 90520.0 -5100000.0 -5.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C10 compound treatment 1481440.0 -3160712.5 -3.49483251379053 -6.4514 -0.9989 3188352 PK04_102054 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1767240.0 -3580000.0 -3.92 1452160.0 -3740000.0 -3.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C11 mock treatment 4904280.0 262127.5 0.289837088871141 0.3966 0.9787 5507720.0 157000.0 0.17 5418040.0 224000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C12 mock treatment 4966880.0 324727.5 0.35905455656657 0.2435 0.4394 5107920.0 -242000.0 -0.27 5521040.0 327000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C13 compound treatment 4053920.0 -588232.5 -0.650414761440114 -1.5177 -0.9004 3188353 PK04_102055 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 4008520.0 -1340000.0 -1.47 4687120.0 -507000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C14 compound treatment 272560.0 -4369592.5 -4.8315036375549 -8.7979 -0.9982 3069395 PK04_102056 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 321120.0 -5030000.0 -5.51 312320.0 -4880000.0 -4.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C15 mock treatment 4869920.0 227767.5 0.251844881362916 0.3933 0.4519 5045360.0 -305000.0 -0.33 5954800.0 761000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C16 mock treatment 4405920.0 -236232.5 -0.26120471944665 -0.3179 -0.3284 4631080.0 -719000.0 -0.79 5690600.0 496000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C17 compound treatment 1696200.0 -2945952.5 -3.25737015976065 -6.0817 -0.9959 3188354 PK04_102057 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1731120.0 -3620000.0 -3.96 1892920.0 -3300000.0 -3.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C18 compound treatment 2570800.0 -2071352.5 -2.29031589064848 -3.6889 -0.9959 3069396 PK04_102058 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 3302840.0 -2050000.0 -2.24 3343920.0 -1850000.0 -1.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C19 compound treatment 1584240.0 -3057912.5 -3.38116549016289 -6.0085 -0.9994 3188355 PK04_102059 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 2028040.0 -3320000.0 -3.64 1818560.0 -3380000.0 -3.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C20 compound treatment 1513080.0 -3129072.5 -3.45984783842498 -6.283 -0.9972 3188356 PK04_102060 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1688720.0 -3660000.0 -4.01 1793480.0 -3400000.0 -3.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C21 compound treatment 2033800.0 -2608352.5 -2.88408234675783 -4.9574 -0.9984 3069397 PK04_102061 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 2565000.0 -2790000.0 -3.05 2551440.0 -2640000.0 -2.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C22 compound treatment 2003120.0 -2639032.5 -2.91800554019067 -5.5317 -0.993 3188357 PK04_102062 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 1941800.0 -3410000.0 -3.73 2274040.0 -2920000.0 -2.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C23 compound treatment 1347400.0 -3294752.5 -3.64304192864509 -6.6767 -0.9976 3188358 PK04_102063 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1487880.0 -3860000.0 -4.23 1515760.0 -3680000.0 -3.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 C24 compound treatment 795000.0 -3847152.5 -4.25383632409165 -7.4585 -0.9999 3069398 PK04_102064 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1460480.0 -3890000.0 -4.26 805000.0 -4390000.0 -4.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D01 compound treatment 2327960.0 -2314192.5 -2.55882659121011 -5.0669 -0.9934 3188359 PK04_102065 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 2268840.0 -3080000.0 -3.37 2361520.0 -2830000.0 -2.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D02 compound treatment 3108000.0 -1534152.5 -1.69632829246982 -3.8481 -0.9811 3069399 PK04_102066 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(I)cc6)c7ccccc73 2822520.0 -2530000.0 -2.77 3001400.0 -2190000.0 -2.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D03 compound treatment 2484240.0 -2157912.5 -2.38602617824779 -4.3369 -0.9852 3188360 PK04_102067 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 2531160.0 -2820000.0 -3.09 3163040.0 -2030000.0 -2.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D04 compound treatment 4749640.0 107487.5 0.118850040877194 -1.0143 -0.504 3188361 PK04_102068 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 3519560.0 -1830000.0 -2.0 5322920.0 129000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D05 compound treatment 1841880.0 -2800272.5 -3.09629027647199 -5.3557 -0.9983 3069400 PK04_102069 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 2326280.0 -3020000.0 -3.31 2335920.0 -2860000.0 -2.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D06 compound treatment 4498440.0 -143712.5 -0.158904398181777 -0.3277 -0.4361 3188362 PK04_102070 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 4727720.0 -623000.0 -0.68 5466320.0 272000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D07 compound treatment 3812440.0 -829712.5 -0.917421695930403 -1.8532 -0.9901 3188363 PK04_102071 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 4183880.0 -1170000.0 -1.28 4182640.0 -1010000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D08 compound treatment 4733920.0 91767.5 0.101468274229077 -0.3337 -0.2561 3069401 PK04_102072 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 4260640.0 -1090000.0 -1.19 5706160.0 512000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D09 compound treatment 1861240.0 -2780912.5 -3.07488372416235 -5.4056 -0.9999 3188364 PK04_102073 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 2436520.0 -2910000.0 -3.19 2108160.0 -3090000.0 -3.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D10 compound treatment 5173360.0 531207.5 0.587361628926827 0.6004 0.7913 3069402 PK04_102074 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 5325560.0 -24700.0 -0.03 5672160.0 478000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D11 mock treatment 4854040.0 211887.5 0.234286201059347 0.4631 0.9952 5596080.0 246000.0 0.27 5491680.0 298000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D12 mock treatment 4249200.0 -392952.5 -0.434491644961468 0.4538 0.4646 5814960.0 465000.0 0.51 5903240.0 709000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D13 compound treatment 4294880.0 -347272.5 -0.383982796330043 -0.5184 -0.6756 3069403 PK04_102075 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 4756600.0 -594000.0 -0.65 5329960.0 136000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D14 compound treatment 3723160.0 -918992.5 -1.01613951567238 -0.8847 -0.8109 3188365 PK04_102076 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 5215800.0 -134000.0 -0.15 4826520.0 -368000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D15 mock treatment 4856840.0 214687.5 0.237382190029749 0.2841 0.4765 5133080.0 -217000.0 -0.24 5685000.0 491000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D16 mock treatment 4695720.0 53567.5 0.0592301389900139 0.5946 0.5498 5255200.0 -95100.0 -0.1 6265080.0 1070000.0 1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D17 compound treatment 4156920.0 -485232.5 -0.536526595743163 -0.652 -0.8959 3188366 PK04_102077 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 4913760.0 -437000.0 -0.48 5079920.0 -114000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D18 compound treatment 4777160.0 135007.5 0.149279189614865 0.154 0.5961 3069404 PK04_102078 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 5278800.0 -71500.0 -0.08 5389160.0 195000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D19 compound treatment 3040360.0 -1601792.5 -1.77111854031198 -2.6347 -0.9826 3188367 PK04_102079 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 4328960.0 -1020000.0 -1.12 3526280.0 -1670000.0 -1.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D20 compound treatment 1786400.0 -2855752.5 -3.15763508649983 -4.3867 -0.9767 3069405 PK04_102080 COc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 3702160.0 -1650000.0 -1.8 2568040.0 -2630000.0 -2.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D21 compound treatment 3537200.0 -1104952.5 -1.22175741172097 -2.1078 -0.9989 3188368 PK04_102081 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 4305600.0 -1040000.0 -1.14 3913760.0 -1280000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D22 compound treatment 4592560.0 -49592.5 -0.0548349403623888 -0.3472 -0.6379 3069440 PK04_102082 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 4855800.0 -494000.0 -0.54 5189120.0 -5040.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D23 compound treatment 2958320.0 -1683832.5 -1.86183101714477 -3.2886 -0.9964 3188485 PK04_102083 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 3778160.0 -1570000.0 -1.72 3089160.0 -2100000.0 -2.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 D24 compound treatment 4188360.0 -453792.5 -0.501763062446929 -1.3949 -0.9355 3069441 PK04_102084 O[C@H](CC=C)c1ccc(O)c(F)c1 4235280.0 -1120000.0 -1.22 4503480.0 -691000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E01 mock treatment 4414880.0 -227272.5 -0.251297554741362 -0.7397 -0.7696 4509000.0 -841000.0 -0.92 5085920.0 -108000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E02 mock treatment 4610040.0 -32112.5 -0.0355071235043043 -0.3393 -0.7486 4951360.0 -399000.0 -0.44 5079280.0 -115000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E03 compound treatment 2310680.0 -2331472.5 -2.57793326599888 -4.5471 -0.9749 3069442 PK04_102085 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 2261800.0 -3090000.0 -3.38 3285360.0 -1910000.0 -1.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E04 compound treatment 2482840.0 -2159312.5 -2.38757417273299 -3.5811 -0.9889 3188486 PK04_102086 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 3370240.0 -1980000.0 -2.17 3553320.0 -1640000.0 -1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E05 compound treatment 2023840.0 -2618312.5 -2.89509522180969 -5.186 -0.9966 3188487 PK04_102087 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 2305880.0 -3040000.0 -3.33 2450600.0 -2740000.0 -2.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E06 compound treatment 2930720.0 -1711432.5 -1.89234862271017 -2.7596 -0.9909 3069443 PK04_102088 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 3978800.0 -1370000.0 -1.5 3813600.0 -1380000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E07 compound treatment 1912280.0 -2729872.5 -3.0184482680733 -4.8947 -0.9988 3188488 PK04_102089 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 2899480.0 -2450000.0 -2.68 2428480.0 -2770000.0 -2.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E08 compound treatment 2272400.0 -2369752.5 -2.62025985806567 -5.4477 -0.9909 3188489 PK04_102090 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 2002280.0 -3350000.0 -3.67 2056440.0 -3140000.0 -3.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E09 mock treatment 4612600.0 -29552.5 -0.0326765050170791 0.1533 0.6958 5451040.0 101000.0 0.11 5381400.0 187000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E10 mock treatment 5050720.0 408567.5 0.451757312023195 0.4264 0.6155 5168360.0 -182000.0 -0.2 5678480.0 484000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E11 compound treatment 2337280.0 -2304872.5 -2.54852137078006 -3.9429 -0.9824 3069444 PK04_102091 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 3828640.0 -1520000.0 -1.67 2589040.0 -2610000.0 -2.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E12 compound treatment 1583520.0 -3058632.5 -3.38196160161242 -5.7046 -0.9996 3188490 PK04_102092 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 2304320.0 -3050000.0 -3.34 2042360.0 -3150000.0 -3.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E13 compound treatment 2287840.0 -2354312.5 -2.60318769031459 -4.131 -0.9914 3069445 PK04_102093 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 3578680.0 -1770000.0 -1.94 2591720.0 -2600000.0 -2.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E14 compound treatment 1856560.0 -2785592.5 -3.08005844858431 -5.6938 -0.9968 3188491 PK04_102094 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 2008360.0 -3340000.0 -3.66 2083240.0 -3110000.0 -3.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E15 compound treatment 765360.0 -3876792.5 -4.28660957876405 -7.8202 -0.9987 3188492 PK04_102095 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 932520.0 -4420000.0 -4.84 789520.0 -4400000.0 -4.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E16 compound treatment 3614560.0 -1027592.5 -1.13621965931014 -1.5328 -0.9167 3069446 PK04_102096 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 5039680.0 -311000.0 -0.34 4019880.0 -1170000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E17 mock treatment 5032960.0 390807.5 0.43211989626807 0.3493 0.6914 5279840.0 -70400.0 -0.08 5443280.0 249000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E18 mock treatment 4900760.0 258607.5 0.285944988451207 0.2773 0.7091 5291360.0 -58900.0 -0.06 5452160.0 258000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E19 compound treatment 1209520.0 -3432632.5 -3.79549727123048 -5.5704 -0.9775 3188493 PK04_102097 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 3305040.0 -2050000.0 -2.24 1594080.0 -3600000.0 -3.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E20 compound treatment 3878000.0 -764152.5 -0.84493132560912 -1.649 -0.9392 3188494 PK04_102098 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 4052080.0 -1300000.0 -1.42 4606720.0 -587000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E21 compound treatment 2019200.0 -2622952.5 -2.90022571781779 -5.4884 -0.9979 3069448 PK04_102099 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 2250400.0 -3100000.0 -3.39 1994400.0 -3200000.0 -3.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E22 compound treatment 1511320.0 -3130832.5 -3.46179388863495 -5.5331 -0.9978 3188495 PK04_102100 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 2658160.0 -2690000.0 -2.95 2031880.0 -3160000.0 -3.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E23 compound treatment 2035360.0 -2606792.5 -2.88235743861718 -5.2563 -0.9985 3069450 PK04_102101 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 2367000.0 -2980000.0 -3.27 2249840.0 -2940000.0 -2.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 E24 compound treatment 2857480.0 -1784672.5 -1.97333084849313 -3.6722 -0.9797 3188496 PK04_102102 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 3818000.0 -1530000.0 -1.68 2494680.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F01 mock treatment 4505400.0 -136752.5 -0.151208654169634 -0.6808 -0.7922 4601480.0 -749000.0 -0.82 4986880.0 -207000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F02 mock treatment 4547840.0 -94312.5 -0.104282307061104 -0.5065 -0.6343 4627480.0 -723000.0 -0.79 5212600.0 18400.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F03 compound treatment 3980200.0 -661952.5 -0.731927728189427 -1.1459 -0.9792 3188497 PK04_102103 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 4635280.0 -715000.0 -0.78 4726040.0 -468000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F04 compound treatment 5004000.0 361847.5 0.400098524631335 0.1718 0.2199 3069264 PK04_102104 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 4872720.0 -478000.0 -0.52 5613160.0 419000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F05 compound treatment 4715680.0 73527.5 0.0813001175075978 -0.3815 -0.6117 3069265 PK04_102105 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 4800160.0 -550000.0 -0.6 5054960.0 -139000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F06 compound treatment 4338280.0 -303872.5 -0.335994967288804 -0.848 -0.9738 3188498 PK04_102106 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 4872960.0 -477000.0 -0.52 4586360.0 -608000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F07 compound treatment 1480440.0 -3161712.5 -3.4959382241371 -6.5052 -0.9966 3188499 PK04_102107 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1522160.0 -3830000.0 -4.19 1627840.0 -3570000.0 -3.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F08 compound treatment 5387120.0 744967.5 0.82371827261013 0.6432 0.5806 3069441 PK04_102108 O[C@H](CC=C)c1ccc(O)c(F)c1 5023200.0 -327000.0 -0.36 5840440.0 646000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F09 mock treatment 4962160.0 320007.5 0.353835603730748 0.5504 0.661 5221600.0 -129000.0 -0.14 5931880.0 738000.0 0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F10 mock treatment 5425360.0 783207.5 0.866000636263056 0.8898 0.8013 5332280.0 -18000.0 -0.02 5886520.0 692000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F11 compound treatment 1967560.0 -2674592.5 -2.95732460011478 -5.0828 -1.0 3188500 PK04_102109 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 2665040.0 -2690000.0 -2.94 2298800.0 -2900000.0 -2.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F12 compound treatment 5012520.0 370367.5 0.409519176784131 -0.3646 -0.38 3069270 PK04_102110 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 5171520.0 -179000.0 -0.2 4351880.0 -842000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F13 compound treatment 3092800.0 -1549352.5 -1.71313508973772 -2.6218 -0.9914 3188501 PK04_102111 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 3900640.0 -1450000.0 -1.59 3958240.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F14 compound treatment 4652440.0 10287.5 0.011374995190363 -0.3447 -0.6803 3188502 PK04_102112 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 5245200.0 -105000.0 -0.12 4702520.0 -492000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F15 compound treatment 4134920.0 -507232.5 -0.560852223367755 -0.8428 -0.9817 3188623 PK04_102113 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 4852040.0 -498000.0 -0.55 4842120.0 -352000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F16 compound treatment 4654160.0 12007.5 0.0132768169864674 0.0169 0.0576 3069312 PK04_102114 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 5169040.0 -181000.0 -0.2 5407800.0 214000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F17 mock treatment 4590160.0 -51992.5 -0.0574886451941624 0.1514 0.6302 5533280.0 183000.0 0.2 5313000.0 119000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F18 mock treatment 4903240.0 261087.5 0.288687150110706 0.3474 0.9277 5435840.0 85600.0 0.09 5412720.0 219000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F19 compound treatment 2780600.0 -1861552.5 -2.05833785993761 -3.3783 -0.9892 3188624 PK04_102115 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 3930840.0 -1420000.0 -1.55 2963560.0 -2230000.0 -2.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F20 compound treatment 4934920.0 292767.5 0.323716053890118 -0.3808 -0.2389 3069314 PK04_102116 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 3999000.0 -1350000.0 -1.48 5688960.0 495000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F21 compound treatment 3996080.0 -646072.5 -0.714369047885858 -1.6168 -0.909 3069316 PK04_102117 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 4843960.0 -506000.0 -0.55 3668080.0 -1530000.0 -1.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F22 compound treatment 4744680.0 102527.5 0.113365717558196 -0.2012 -0.5215 3188625 PK04_102118 O[C@@H](CC=C)c1ccc(O)c2ccccc12 5250000.0 -100000.0 -0.11 4843440.0 -351000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F23 compound treatment 2497880.0 -2144272.5 -2.37094428912054 -2.9612 -0.9469 3188626 PK04_102119 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 4475920.0 -874000.0 -0.96 3400160.0 -1790000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 F24 compound treatment 3901680.0 -740472.5 -0.818748104602287 -1.4424 -0.9884 3069318 PK04_102120 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 4440760.0 -910000.0 -1.0 4513120.0 -681000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G01 compound treatment 1890120.0 -2752032.5 -3.04295080935334 -5.0083 -0.9929 3069320 PK04_102121 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO)nn2)/C=C/C 2410400.0 -2940000.0 -3.22 2790520.0 -2400000.0 -2.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G02 compound treatment 4959560.0 317407.5 0.35096075682966 -1.0919 -0.6705 3188627 PK04_102122 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 4246760.0 -1100000.0 -1.21 4164160.0 -1030000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G03 mock treatment 4755360.0 113207.5 0.125174704059588 0.2434 0.4877 5204560.0 -146000.0 -0.16 5648600.0 454000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G04 mock treatment 4936440.0 294287.5 0.325396733616908 -0.133 -0.2465 4983080.0 -367000.0 -0.4 5041000.0 -153000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G05 compound treatment 2985280.0 -1656872.5 -1.83202106620118 -2.5464 -0.9759 3069321 PK04_102123 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 3942680.0 -1410000.0 -1.54 4160880.0 -1030000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G06 compound treatment 147680.0 -4494472.5 -4.96958474563485 -8.753 -0.9999 3188628 PK04_102124 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 626280.0 -4720000.0 -5.17 194360.0 -5000000.0 -5.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G07 compound treatment 3206960.0 -1435192.5 -1.58690719657302 -2.5969 -0.9325 3069362 PK04_102125 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4ccccc43 4667120.0 -683000.0 -0.75 3039040.0 -2160000.0 -2.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G08 compound treatment 2109360.0 -2532792.5 -2.80053487297082 -5.1817 -0.9949 3188629 PK04_102126 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 2229120.0 -3120000.0 -3.42 2447520.0 -2750000.0 -2.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G09 compound treatment 293960.0 -4348192.5 -4.80784143613825 -8.6826 -0.9991 3188630 PK04_102127 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 502920.0 -4850000.0 -5.31 289320.0 -4900000.0 -4.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G10 compound treatment 2344280.0 -2297872.5 -2.54078139835405 -4.5855 -0.9991 3188631 PK04_102128 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 2795600.0 -2550000.0 -2.8 2599560.0 -2590000.0 -2.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G11 compound treatment 128720.0 -4513432.5 -4.99054901380587 -8.9871 -0.9991 3069365 PK04_102129 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 334520.0 -5020000.0 -5.49 129520.0 -5060000.0 -5.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G12 compound treatment 3890680.0 -751472.5 -0.830910918414583 -1.0898 -0.7054 3188632 PK04_102130 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 5556760.0 206000.0 0.23 3915920.0 -1280000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G13 compound treatment 2059680.0 -2582472.5 -2.85546656298854 -4.947 -1.0 3069368 PK04_102131 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccccc43 2722560.0 -2630000.0 -2.88 2368920.0 -2830000.0 -2.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G14 compound treatment 1521640.0 -3120512.5 -3.45038295785832 -5.7828 -0.9995 3069370 PK04_102132 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 2433280.0 -2920000.0 -3.19 1834920.0 -3360000.0 -3.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G15 compound treatment 2507640.0 -2134512.5 -2.36015255613799 -3.6317 -0.9872 3188633 PK04_102133 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 3871880.0 -1480000.0 -1.62 2891280.0 -2300000.0 -2.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G16 compound treatment 1405120.0 -3237032.5 -3.57922032744093 -6.4968 -0.9989 3188634 PK04_102134 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1709160.0 -3640000.0 -3.99 1521280.0 -3670000.0 -3.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G17 compound treatment 139560.0 -4502592.5 -4.97856311364902 -8.4005 -0.9989 3188635 PK04_102135 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1215440.0 -4130000.0 -4.53 168720.0 -5030000.0 -5.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G18 compound treatment 3964400.0 -677752.5 -0.74939795166527 -0.4685 -0.4827 3069408 PK04_102136 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 5719240.0 369000.0 0.4 4729680.0 -464000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G19 mock treatment 4945320.0 303167.5 0.33521544149447 0.5869 0.7719 5973400.0 623000.0 0.68 5193040.0 -1120.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G20 mock treatment 5193880.0 551727.5 0.610050805238491 0.47 0.7383 5371720.0 21400.0 0.02 5374080.0 180000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G21 compound treatment 335520.0 -4306632.5 -4.76188811413471 -8.2413 -1.0 3188636 PK04_102137 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 1052360.0 -4300000.0 -4.71 405520.0 -4790000.0 -4.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G22 compound treatment 717840.0 -3924312.5 -4.33915293443317 -7.0328 -0.9911 3188637 PK04_102138 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 2338040.0 -3010000.0 -3.3 667080.0 -4530000.0 -4.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G23 compound treatment 3362280.0 -1279872.5 -1.41516826554341 -1.5781 -0.9266 3069412 PK04_102139 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 4858720.0 -492000.0 -0.54 4417080.0 -777000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 G24 compound treatment 1868440.0 -2773712.5 -3.06692260966703 -5.581 -0.9936 3188638 PK04_102140 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 1945840.0 -3400000.0 -3.73 2333080.0 -2860000.0 -2.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H01 compound treatment 2152160.0 -2489992.5 -2.75321047013753 -5.121 -0.9867 3188639 PK04_102141 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 2036640.0 -3310000.0 -3.63 2715320.0 -2480000.0 -2.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H02 compound treatment 4515640.0 -126512.5 -0.139886180220733 -1.5013 -0.8122 3069414 PK04_102142 CSc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 3834160.0 -1520000.0 -1.66 4396880.0 -797000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H03 mock treatment 5140280.0 498127.5 0.550784730662214 0.2752 0.4908 5374960.0 24700.0 0.03 5093320.0 -101000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H04 mock treatment 5157600.0 515447.5 0.569935633864846 0.478 0.7914 5415240.0 65000.0 0.07 5380400.0 186000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H05 compound treatment 2467280.0 -2174872.5 -2.40477902572565 -4.1338 -1.0 3188755 PK04_102143 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 3186880.0 -2160000.0 -2.37 2816760.0 -2380000.0 -2.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H06 compound treatment 5129960.0 487807.5 0.539373799885587 0.6102 0.7243 3188362 PK04_102144 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 5241920.0 -108000.0 -0.12 5828080.0 634000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H07 compound treatment 2557280.0 -2084872.5 -2.30526509453414 -3.6958 -0.9961 3188756 PK04_102145 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 3644000.0 -1710000.0 -1.87 2974600.0 -2220000.0 -2.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H08 compound treatment 5212200.0 570047.5 0.630307418787696 0.4336 0.6253 3069452 PK04_102146 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c(F)c2)cc1 5227080.0 -123000.0 -0.13 5448960.0 255000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H09 compound treatment 3145840.0 -1496312.5 -1.65448821295553 -3.559 -0.9837 3188757 PK04_102147 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 3567960.0 -1780000.0 -1.95 2645240.0 -2550000.0 -2.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H10 compound treatment 2968080.0 -1674072.5 -1.85103928416222 -2.7147 -0.9548 3069454 PK04_102148 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 4545880.0 -804000.0 -0.88 3231120.0 -1960000.0 -1.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H11 compound treatment 1641120.0 -3001032.5 -3.31827268564986 -5.2851 -0.9879 3188758 PK04_102149 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 3177960.0 -2170000.0 -2.38 1749680.0 -3440000.0 -3.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H12 compound treatment 4786760.0 144607.5 0.15989400894196 0.5627 0.8639 3069456 PK04_102150 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 5889120.0 539000.0 0.59 5417960.0 224000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H13 compound treatment 2201360.0 -2440792.5 -2.69880952108617 -3.941 -0.9623 3188759 PK04_102151 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 4101920.0 -1250000.0 -1.37 2443920.0 -2750000.0 -2.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H14 compound treatment 2839560.0 -1802592.5 -1.9931451779037 -1.4504 -0.4307 3069458 PK04_102152 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 6850160.0 1500000.0 1.64 3040280.0 -2150000.0 -2.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H15 compound treatment 3595120.0 -1047032.5 -1.1577146684475 -1.4166 -0.9134 3188760 PK04_102153 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 5065280.0 -285000.0 -0.31 4213880.0 -980000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H16 compound treatment 4775120.0 132967.5 0.147023540507858 0.7023 0.9113 3069460 PK04_102154 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 5823960.0 474000.0 0.52 5742880.0 549000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H17 compound treatment 2145200.0 -2496952.5 -2.76090621414967 -4.9862 -0.9986 3188761 PK04_102155 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 2525000.0 -2830000.0 -3.09 2422640.0 -2770000.0 -2.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H18 compound treatment 2683800.0 -1958352.5 -2.16537062148581 -2.3938 -0.7411 3069461 PK04_102156 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c3ccccc23)cc1 5701640.0 351000.0 0.38 2836920.0 -2360000.0 -2.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H19 mock treatment 4878880.0 236727.5 0.261752046068204 0.4047 0.9036 5672720.0 322000.0 0.35 5280000.0 85800.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H20 mock treatment 4230120.0 -412032.5 -0.455588598374068 0.5277 0.4924 5940080.0 590000.0 0.65 5915280.0 721000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H21 compound treatment 2503600.0 -2138552.5 -2.36461962593815 -2.7272 -0.894 3188762 PK04_102157 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 4896240.0 -454000.0 -0.5 3339000.0 -1860000.0 -1.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H22 compound treatment 4485800.0 -156352.5 -0.172880576962452 -0.0283 -0.0684 3069504 PK04_102158 O[C@H](CC=C)c1ccc(O)c2ccccc12 5642760.0 292000.0 0.32 4998480.0 -196000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H23 compound treatment 2042640.0 -2599512.5 -2.87430786729413 -4.035 -0.9441 3188763 PK04_102159 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 4273200.0 -1080000.0 -1.18 2269560.0 -2920000.0 -2.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 H24 compound treatment 4226080.0 -416072.5 -0.46005566817422 -1.1053 -0.9749 3069401 PK04_102160 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 4768240.0 -582000.0 -0.64 4380160.0 -814000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I01 compound treatment 2909360.0 -1732792.5 -1.91596659571295 -3.9599 -0.9893 3069507 PK04_102161 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 2856000.0 -2490000.0 -2.73 2990840.0 -2200000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I02 compound treatment 3787360.0 -854792.5 -0.945152911422437 -3.4559 -0.9191 3188764 PK04_102162 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 2573640.0 -2780000.0 -3.04 3201320.0 -1990000.0 -2.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I03 compound treatment 4004440.0 -637712.5 -0.705125309388514 -1.8116 -0.8584 3188765 PK04_102163 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 3594720.0 -1760000.0 -1.92 4685800.0 -508000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I04 compound treatment 1078560.0 -3563592.5 -3.94030109821759 -6.5629 -0.9987 3069594 PK04_102164 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 1777400.0 -3570000.0 -3.91 1692440.0 -3500000.0 -3.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I05 mock treatment 4698680.0 56527.5 0.062503041615868 0.0914 0.1901 5089320.0 -261000.0 -0.29 5574400.0 380000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I06 mock treatment 4529240.0 -112912.5 -0.124848519507349 0.0515 0.128 5221320.0 -129000.0 -0.14 5548120.0 354000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I07 compound treatment 4625600.0 -16552.5 -0.0183022705116387 -0.3142 -0.6617 3188766 PK04_102165 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 4919880.0 -430000.0 -0.47 5139800.0 -54400.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I08 compound treatment 4005760.0 -636392.5 -0.703665771731038 -1.1226 -0.9946 3188767 PK04_102166 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 4845560.0 -505000.0 -0.55 4508600.0 -686000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I09 compound treatment 5072680.0 430527.5 0.476038711233923 0.4428 0.6676 3069598 PK04_102167 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 5216080.0 -134000.0 -0.15 5630480.0 436000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I10 compound treatment 1893920.0 -2748232.5 -3.03874911003637 -4.6559 -0.9958 3188768 PK04_102168 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 3054360.0 -2300000.0 -2.51 2691840.0 -2500000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I11 compound treatment 446600.0 -4195552.5 -4.63906580883745 -7.8415 -0.9991 3188769 PK04_102169 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 1462320.0 -3890000.0 -4.26 525920.0 -4670000.0 -4.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I12 compound treatment 1850520.0 -2791632.5 -3.08673693907761 -5.2197 -0.999 3069636 PK04_102170 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 2493400.0 -2860000.0 -3.13 2378800.0 -2820000.0 -2.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I13 compound treatment 726080.0 -3916072.5 -4.33004188117741 -6.8183 -0.9932 3188770 PK04_102171 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 2348920.0 -3000000.0 -3.29 1016320.0 -4180000.0 -4.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I14 compound treatment 1397440.0 -3244712.5 -3.58771218290261 -6.258 -0.9995 3188771 PK04_102172 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1917040.0 -3430000.0 -3.76 1714880.0 -3480000.0 -3.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I15 compound treatment 4659160.0 17007.5 0.0188053687193291 -0.4419 -0.5426 3069640 PK04_102173 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 5377200.0 26900.0 0.03 4383360.0 -811000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I16 compound treatment 1278400.0 -3363752.5 -3.71933594255858 -5.5022 -0.9819 3188888 PK04_102174 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 3230880.0 -2120000.0 -2.32 1716760.0 -3480000.0 -3.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I17 compound treatment 2664800.0 -1977352.5 -2.18637911807068 -2.4944 -0.8748 3069645 PK04_102175 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 5044560.0 -306000.0 -0.33 3401320.0 -1790000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I18 compound treatment 2708800.0 -1933352.5 -2.1377278628215 -2.5438 -0.851 3188889 PK04_102176 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 5179440.0 -171000.0 -0.19 3120400.0 -2070000.0 -2.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I19 compound treatment 1760240.0 -2881912.5 -3.18656046916616 -5.5345 -0.999 3069647 PK04_102177 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 2265680.0 -3080000.0 -3.38 2183520.0 -3010000.0 -3.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I20 compound treatment 1489360.0 -3152792.5 -3.48607528784568 -6.4119 -0.9971 3188890 PK04_102178 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1602360.0 -3750000.0 -4.1 1691520.0 -3500000.0 -3.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I21 mock treatment 4435400.0 -206752.5 -0.228608378429698 0.0989 0.2695 5564840.0 215000.0 0.23 5358480.0 164000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I22 mock treatment 4748200.0 106047.5 0.11725781797813 -0.2005 -0.5356 5226000.0 -124000.0 -0.14 4866960.0 -327000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I23 compound treatment 415120.0 -4227032.5 -4.67387357054755 -8.2706 -0.9994 3188891 PK04_102179 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 777720.0 -4570000.0 -5.01 566960.0 -4630000.0 -4.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 I24 compound treatment 508080.0 -4134072.5 -4.57108673673018 -8.273 -0.9986 3069706 PK04_102180 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 664680.0 -4690000.0 -5.13 583720.0 -4610000.0 -4.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J01 compound treatment 1761360.0 -2880792.5 -3.185322073578 -5.971 -0.9962 3188892 PK04_102181 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1817040.0 -3530000.0 -3.87 1918440.0 -3280000.0 -3.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J02 compound treatment 4462880.0 -179272.5 -0.19822345810589 -1.4708 -0.8791 3069707 PK04_102182 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(OCCO)cc2)cc1 4272840.0 -1080000.0 -1.18 4028960.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J03 compound treatment 1831920.0 -2810232.5 -3.10730315152385 -5.8032 -0.9973 3188893 PK04_102183 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1980480.0 -3370000.0 -3.69 1951920.0 -3240000.0 -3.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J04 compound treatment 4643680.0 1527.5 0.00168897255438925 0.1048 0.7896 3069711 PK04_102184 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 5407880.0 57600.0 0.06 5310560.0 116000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J05 mock treatment 5032760.0 390607.5 0.431898754198755 0.3066 0.6144 5240600.0 -110000.0 -0.12 5412720.0 219000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J06 mock treatment 4856640.0 214487.5 0.237161047960435 0.4372 0.8022 5377960.0 27700.0 0.03 5682200.0 488000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J07 compound treatment 3135640.0 -1506512.5 -1.66576645849056 -3.6489 -0.9771 3188894 PK04_102185 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 3600920.0 -1750000.0 -1.92 2465320.0 -2730000.0 -2.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J08 compound treatment 2712640.0 -1929512.5 -2.13348193509066 -3.7 -0.9402 3069714 PK04_102186 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 4263800.0 -1090000.0 -1.19 2119880.0 -3070000.0 -3.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J09 compound treatment 3255080.0 -1387072.5 -1.53370041469596 -3.045 -0.9959 3188895 PK04_102187 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 3653680.0 -1700000.0 -1.86 3318400.0 -1880000.0 -1.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J10 compound treatment 5050920.0 408767.5 0.451978454092509 0.472 0.8762 3069716 PK04_102188 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 5427880.0 77600.0 0.08 5473800.0 280000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J11 compound treatment 1789360.0 -2852792.5 -3.15436218387397 -5.4184 -0.9996 3188896 PK04_102189 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 2605760.0 -2740000.0 -3.01 1980640.0 -3210000.0 -3.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J12 compound treatment 2389960.0 -2252192.5 -2.49027254972263 -4.2236 -0.9923 3069744 PK04_102190 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 2808680.0 -2540000.0 -2.78 3159600.0 -2030000.0 -2.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J13 compound treatment 3285480.0 -1356672.5 -1.50008682016016 -2.0492 -0.9666 3188897 PK04_102191 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 4659880.0 -690000.0 -0.76 3905560.0 -1290000.0 -1.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J14 compound treatment 5144760.0 502607.5 0.555738313014858 0.6638 0.8842 3069746 PK04_102192 OCCOc1ccc(cc1)[C@@H](O)CC=C 5802200.0 452000.0 0.49 5292840.0 98700.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J15 compound treatment 671320.0 -3970832.5 -4.39059057975571 -5.2358 -0.9026 3069749 PK04_102193 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 4409840.0 -940000.0 -1.03 1559040.0 -3640000.0 -3.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J16 compound treatment 4136600.0 -505552.5 -0.558994629985513 -0.3732 -0.6502 3188898 PK04_102194 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 5384400.0 34100.0 0.04 5069840.0 -124000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J17 compound treatment 2999680.0 -1642472.5 -1.81609883721054 -2.3784 -0.7664 3188899 PK04_102195 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 5537360.0 187000.0 0.2 2694760.0 -2500000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J18 compound treatment 4856240.0 214087.5 0.236718763821806 0.2001 0.1899 3069504 PK04_102196 O[C@H](CC=C)c1ccc(O)c2ccccc12 6061600.0 711000.0 0.78 4527480.0 -667000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J19 compound treatment 3586440.0 -1055712.5 -1.16731223425575 -1.9645 -0.9255 3188900 PK04_102197 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 4848200.0 -502000.0 -0.55 3514760.0 -1680000.0 -1.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J20 compound treatment 4666040.0 23887.5 0.0264126559037468 -0.4529 -0.4804 3069264 PK04_102198 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 5462920.0 113000.0 0.12 4263280.0 -931000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J21 mock treatment 4627960.0 -14192.5 -0.0156927940937279 -0.1249 -0.4234 5425400.0 75100.0 0.08 4912240.0 -282000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J22 mock treatment 4613800.0 -28352.5 -0.0313496526011923 -0.2021 -0.8306 5149120.0 -201000.0 -0.22 5096160.0 -98000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J23 compound treatment 2953920.0 -1688232.5 -1.86669614266969 -2.15 -0.9002 3069786 PK04_102199 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 4956520.0 -394000.0 -0.43 3773280.0 -1420000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 J24 compound treatment 4026000.0 -616152.5 -0.681286194316414 -1.5864 -0.9815 3188901 PK04_102200 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 4332640.0 -1020000.0 -1.11 4245600.0 -949000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K01 compound treatment 3304520.0 -1337632.5 -1.47903409516143 -2.5145 -0.9847 3069787 PK04_102201 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(CCO)nn2)/C=C/C 3750160.0 -1600000.0 -1.75 4074280.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K02 compound treatment 861400.0 -3780752.5 -4.18041715707924 -8.1463 -0.9956 3188902 PK04_102202 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 539960.0 -4810000.0 -5.27 549280.0 -4640000.0 -4.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K03 compound treatment 4047200.0 -594952.5 -0.65784513496908 -1.6938 -0.8456 3188903 PK04_102203 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 3668760.0 -1680000.0 -1.84 4761240.0 -433000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K04 compound treatment 1828320.0 -2813832.5 -3.11128370877152 -5.5495 -0.9976 3069790 PK04_102204 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 2145120.0 -3210000.0 -3.51 2214120.0 -2980000.0 -2.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K05 compound treatment 4592480.0 -49672.5 -0.0549233971901146 0.1329 0.5973 3188904 PK04_102205 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 5431120.0 80800.0 0.09 5390040.0 196000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K06 compound treatment 366480.0 -4275672.5 -4.72765532180483 -8.5827 -0.9984 3189012 PK04_102206 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 466440.0 -4880000.0 -5.35 421560.0 -4770000.0 -4.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K07 mock treatment 4720080.0 77927.5 0.0861652430325161 0.2741 0.6351 5735240.0 385000.0 0.42 5161240.0 -32900.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K08 mock treatment 4576280.0 -65872.5 -0.0728359048045865 -0.1424 -0.9718 5292000.0 -58300.0 -0.06 5084600.0 -110000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K09 compound treatment 2239600.0 -2402552.5 -2.65652715743324 -4.7315 -0.9967 3069821 PK04_102207 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 2580640.0 -2770000.0 -3.03 2697440.0 -2500000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K10 compound treatment 3820520.0 -821632.5 -0.908487556330098 -2.5034 -0.9088 3189013 PK04_102208 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 4394240.0 -956000.0 -1.05 2822080.0 -2370000.0 -2.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K11 compound treatment 439960.0 -4202192.5 -4.64640772553869 -8.4934 -0.9981 3069825 PK04_102209 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 481040.0 -4870000.0 -5.33 478800.0 -4720000.0 -4.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K12 compound treatment 814960.0 -3827192.5 -4.23176634557406 -7.096 -0.9957 3189014 PK04_102210 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 2085440.0 -3260000.0 -3.58 726680.0 -4470000.0 -4.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K13 compound treatment 4505880.0 -136272.5 -0.150677913203279 -0.1831 -0.5692 3189015 PK04_102211 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 5107320.0 -243000.0 -0.27 5293480.0 99300.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K14 compound treatment 1848800.0 -2793352.5 -3.08863876087371 -5.4653 -0.9986 3069831 PK04_102212 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 2262320.0 -3090000.0 -3.38 2209000.0 -2990000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K15 mock treatment 4792600.0 150447.5 0.166351357365942 0.4581 0.6066 6016480.0 666000.0 0.73 5092120.0 -102000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K16 mock treatment 4627800.0 -14352.5 -0.0158697077491795 0.2991 0.7734 5647280.0 297000.0 0.33 5402120.0 208000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K17 compound treatment 475720.0 -4166432.5 -4.60686752354526 -8.2491 -0.9996 3189016 PK04_102213 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 861400.0 -4490000.0 -4.92 446040.0 -4750000.0 -4.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K18 compound treatment 1742080.0 -2900072.5 -3.20664016905991 -5.6081 -0.9987 3069867 PK04_102214 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 2197040.0 -3150000.0 -3.45 2151400.0 -3040000.0 -3.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K19 compound treatment 2272240.0 -2369912.5 -2.62043677172112 -4.6932 -0.9966 3189017 PK04_102215 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 2596640.0 -2750000.0 -3.02 2710200.0 -2480000.0 -2.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K20 compound treatment 2411400.0 -2230752.5 -2.46656611989211 -3.7118 -0.9749 3069873 PK04_102216 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 4025120.0 -1330000.0 -1.45 2691840.0 -2500000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K21 compound treatment 1545000.0 -3097152.5 -3.42455356416239 -6.1953 -0.9982 3189018 PK04_102217 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1804880.0 -3550000.0 -3.88 1782920.0 -3410000.0 -3.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K22 compound treatment 2516840.0 -2125312.5 -2.34998002094953 -3.5261 -0.9554 3189019 PK04_102218 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 4293640.0 -1060000.0 -1.16 2603200.0 -2590000.0 -2.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K23 mock treatment 4191560.0 -450592.5 -0.498224789337897 -0.554 -0.7236 5450320.0 100000.0 0.11 4625360.0 -569000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 K24 mock treatment 3939840.0 -702312.5 -0.776554197777087 -1.2168 -0.9675 4939320.0 -411000.0 -0.45 4316400.0 -878000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L01 compound treatment 1913840.0 -2728312.5 -3.01672335993265 -5.5795 -0.9939 3069879 PK04_102219 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1949040.0 -3400000.0 -3.72 2282040.0 -2910000.0 -2.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L02 compound treatment 3953760.0 -688392.5 -0.7611627097528 -1.5943 -0.9699 3189020 PK04_102220 C[C@@H](C=C)[C@H](O)c1ccc(OCCO)cc1 4211080.0 -1140000.0 -1.25 4444080.0 -750000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L03 compound treatment 1943920.0 -2698232.5 -2.98346359270775 -5.5327 -0.9982 3189021 PK04_102221 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 2203520.0 -3150000.0 -3.45 2052040.0 -3140000.0 -3.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L04 compound treatment 4519760.0 -122392.5 -0.135330653592855 -0.239 -0.5299 3069907 PK04_102222 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 5470040.0 120000.0 0.13 4785840.0 -408000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L05 compound treatment 2985960.0 -1656192.5 -1.83126918316551 -2.9614 -0.9976 3189022 PK04_102223 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 3754560.0 -1600000.0 -1.75 3649200.0 -1540000.0 -1.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L06 compound treatment 4622200.0 -19952.5 -0.0220616856899846 0.2821 0.7449 3069909 PK04_102224 C[C@@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 5655680.0 305000.0 0.33 5369720.0 176000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L07 mock treatment 3907280.0 -734872.5 -0.812556126661482 -1.1449 -0.8255 5306960.0 -43300.0 -0.05 4075080.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L08 mock treatment 4972840.0 330687.5 0.365644590232141 0.2274 0.3852 5662280.0 312000.0 0.34 4881880.0 -312000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L09 compound treatment 2134720.0 -2507432.5 -2.77249405858175 -5.4098 -0.9968 3189023 PK04_102225 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 2286160.0 -3060000.0 -3.36 1963720.0 -3230000.0 -3.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L10 compound treatment 4532560.0 -109592.5 -0.121177561156729 -0.3657 -0.5944 3069912 PK04_102226 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 5427880.0 77600.0 0.08 4599000.0 -595000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L11 compound treatment 3953480.0 -688672.5 -0.76147230864984 -1.2533 -0.764 3189024 PK04_102227 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 5389720.0 39400.0 0.04 3746920.0 -1450000.0 -1.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L12 compound treatment 4728920.0 86767.5 0.0959397224962155 0.0938 0.5984 3069746 PK04_102228 OCCOc1ccc(cc1)[C@@H](O)CC=C 5454800.0 105000.0 0.11 5146480.0 -47700.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L13 compound treatment 2604680.0 -2037472.5 -2.25285442410661 -3.2754 -0.8969 3069917 PK04_102229 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 4791680.0 -559000.0 -0.61 2395600.0 -2800000.0 -2.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L14 compound treatment 4598320.0 -43832.5 -0.0484660487661321 0.4164 0.4353 3069920 PK04_102230 O[C@@H](CC=C)c1ccc(O)c(F)c1 6208680.0 858000.0 0.94 5024360.0 -170000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L15 mock treatment 4816120.0 173967.5 0.192357664717324 0.3268 0.3958 6010400.0 660000.0 0.72 4846120.0 -348000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L16 mock treatment 4231240.0 -410912.5 -0.454350202785907 0.0505 0.0709 5851320.0 501000.0 0.55 5187320.0 -6840.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L17 compound treatment 3264720.0 -1377432.5 -1.52304136695501 -1.8026 -0.8502 3189025 PK04_102231 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 5231840.0 -118000.0 -0.13 3730000.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L18 compound treatment 4649200.0 7047.5 0.00779249366746857 0.1831 0.3402 3069953 PK04_102232 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 5808960.0 459000.0 0.5 5001840.0 -192000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L19 compound treatment 889960.0 -3752192.5 -4.14883806958114 -5.8274 -0.927 3189026 PK04_102233 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 4025880.0 -1320000.0 -1.45 716080.0 -4480000.0 -4.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L20 compound treatment 4723040.0 80887.5 0.0894381456583702 -0.2249 -0.4048 3069956 PK04_102234 CO[C@@H](C=C)[C@@H](O)c1ccc(OC)c(O)c1 5410040.0 59800.0 0.07 4651640.0 -543000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L21 compound treatment 3623760.0 -1018392.5 -1.12604712412167 -1.337 -0.8057 3189027 PK04_102235 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 5376680.0 26400.0 0.03 3979880.0 -1210000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L22 compound treatment 4433880.0 -208272.5 -0.230289058156488 -0.5195 -0.6788 3069961 PK04_102236 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 5403320.0 53000.0 0.06 4469120.0 -725000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L23 mock treatment 4556280.0 -85872.5 -0.0949501117360333 -0.5339 -0.8003 5167000.0 -183000.0 -0.2 4567320.0 -627000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 L24 mock treatment 4259040.0 -383112.5 -0.423611455151196 -1.3938 -0.9482 4454160.0 -896000.0 -0.98 4188680.0 -1010000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M01 compound treatment 894120.0 -3748032.5 -4.1442383145394 -7.4376 -0.9963 3069962 PK04_102237 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 965480.0 -4380000.0 -4.8 1271960.0 -3920000.0 -3.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M02 compound treatment 119800.0 -4522352.5 -5.00041195009729 -9.1611 -0.998 3188628 PK04_102238 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 95320.0 -5250000.0 -5.75 100200.0 -5090000.0 -5.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M03 compound treatment 2110600.0 -2531552.5 -2.79916379214108 -5.6548 -0.9948 3189028 PK04_102239 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 2226560.0 -3120000.0 -3.42 1632560.0 -3560000.0 -3.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M04 compound treatment 2033960.0 -2608192.5 -2.88390543310238 -5.1662 -0.9994 3189141 PK04_102240 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 2494160.0 -2860000.0 -3.13 2268160.0 -2930000.0 -2.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M05 compound treatment 1610280.0 -3031872.5 -3.35237279273815 -6.0433 -0.9979 3069277 PK04_102241 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1872040.0 -3480000.0 -3.81 1900040.0 -3290000.0 -3.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M06 compound treatment 1547960.0 -3094192.5 -3.42128066153654 -5.3585 -0.9968 3189142 PK04_102242 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 2579680.0 -2770000.0 -3.03 2378400.0 -2820000.0 -2.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M07 compound treatment 528360.0 -4113792.5 -4.54866293090169 -7.1965 -0.9919 3189143 PK04_102243 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 2241000.0 -3110000.0 -3.41 699160.0 -4490000.0 -4.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M08 compound treatment 1032840.0 -3609312.5 -3.99085417526288 -7.2454 -0.995 3069284 PK04_102244 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 999640.0 -4350000.0 -4.76 1413600.0 -3780000.0 -3.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M09 mock treatment 4401800.0 -240352.5 -0.265760246074528 -0.3044 -0.4096 5662760.0 312000.0 0.34 4592720.0 -601000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M10 mock treatment 4685840.0 43687.5 0.0483057207658791 0.7194 0.6511 6354120.0 1000000.0 1.1 5292160.0 98000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M11 compound treatment 4922200.0 280047.5 0.309651418281717 0.2053 0.257 3189144 PK04_102245 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 5846440.0 496000.0 0.54 4698600.0 -496000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M12 compound treatment 2989440.0 -1652712.5 -1.82742131115944 -1.8531 -0.8264 3189145 PK04_102246 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 5272040.0 -78200.0 -0.09 3902160.0 -1290000.0 -1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M13 mock treatment 4474360.0 -167792.5 -0.185529903327239 0.3639 0.4607 6049960.0 700000.0 0.77 5243600.0 49400.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M14 mock treatment 4623480.0 -18672.5 -0.020646376446372 0.3228 0.6461 5798920.0 449000.0 0.49 5282280.0 88100.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M15 compound treatment 3257560.0 -1384592.5 -1.53095825303646 -2.1575 -0.9071 3189146 PK04_102247 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 4948960.0 -401000.0 -0.44 3434080.0 -1760000.0 -1.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M16 compound treatment 2680480.0 -1961672.5 -2.16904157983643 -2.2957 -0.8551 3189147 PK04_102248 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 5127320.0 -223000.0 -0.24 3636680.0 -1560000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M17 compound treatment 1530480.0 -3111672.5 -3.44060847839462 -5.9255 -0.9988 3069327 PK04_102249 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 2421240.0 -2930000.0 -3.21 1591960.0 -3600000.0 -3.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M18 compound treatment 2539720.0 -2102432.5 -2.32468136821995 -4.2235 -0.9966 3189148 PK04_102250 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 2865640.0 -2480000.0 -2.72 2932600.0 -2260000.0 -2.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M19 compound treatment 3017160.0 -1624992.5 -1.79677102035245 -3.5865 -0.9649 3069330 PK04_102251 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 3925920.0 -1420000.0 -1.56 2348920.0 -2850000.0 -2.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M20 compound treatment 1478000.0 -3164152.5 -3.49863615738274 -5.6362 -0.9944 3189149 PK04_102252 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 2824000.0 -2530000.0 -2.77 1709680.0 -3480000.0 -3.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M21 compound treatment 1762880.0 -2879272.5 -3.18364139385121 -5.6526 -0.9986 3189150 PK04_102253 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 2148600.0 -3200000.0 -3.51 2104440.0 -3090000.0 -3.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M22 compound treatment 3527200.0 -1114952.5 -1.2328145151867 -2.1047 -0.9999 3189151 PK04_102254 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 4245000.0 -1110000.0 -1.21 3996200.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M23 compound treatment 1931880.0 -2710272.5 -2.99677634528048 -5.5658 -0.9982 3189152 PK04_102255 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 2190440.0 -3160000.0 -3.46 2022480.0 -3170000.0 -3.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 M24 compound treatment 1458360.0 -3183792.5 -3.52035230858942 -7.588 -0.9872 3069375 PK04_102256 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 550160.0 -4800000.0 -5.26 844040.0 -4350000.0 -4.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N01 compound treatment 1663320.0 -2978832.5 -3.29372591595595 -6.1213 -0.9977 3189153 PK04_102257 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1827200.0 -3520000.0 -3.86 1755920.0 -3440000.0 -3.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N02 compound treatment 4566240.0 -75912.5 -0.0839372366841728 -0.7861 -0.8341 3069379 PK04_102258 CSc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 4931480.0 -419000.0 -0.46 4378160.0 -816000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N03 compound treatment 3652880.0 -989272.5 -1.09384883882949 -1.414 -0.8661 3189154 PK04_102259 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 5210480.0 -140000.0 -0.15 3996200.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N04 compound treatment 4535160.0 -106992.5 -0.118302714255641 -0.3136 -0.6138 3069716 PK04_102260 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 5412000.0 61700.0 0.07 4703400.0 -491000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N05 compound treatment 4267000.0 -375152.5 -0.41481000079248 -1.1839 -0.895 3069403 PK04_102261 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 4919760.0 -431000.0 -0.47 4033960.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N06 compound treatment 4554880.0 -87272.5 -0.0964981062212346 0.0196 0.0338 3069417 PK04_102262 C[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 5774720.0 424000.0 0.46 4861040.0 -333000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N07 compound treatment 1826120.0 -2816032.5 -3.11371627153397 -5.5981 -0.9991 3189155 PK04_102263 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 2226520.0 -3120000.0 -3.42 2043840.0 -3150000.0 -3.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N08 compound treatment 3433360.0 -1208792.5 -1.33657437410905 -1.6368 -0.9162 3069421 PK04_102264 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 5009520.0 -341000.0 -0.37 4072880.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N09 mock treatment 4155320.0 -486832.5 -0.538295732297679 -0.3453 -0.3763 5802120.0 452000.0 0.49 4641520.0 -553000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N10 mock treatment 4406560.0 -235592.5 -0.260497064824844 -0.4136 -0.8082 5335960.0 -14300.0 -0.02 4755600.0 -439000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N11 compound treatment 2259920.0 -2382232.5 -2.63405912319089 -4.3122 -0.9986 3189156 PK04_102265 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 3237000.0 -2110000.0 -2.31 2682480.0 -2510000.0 -2.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N12 compound treatment 4500280.0 -141872.5 -0.156869891144084 -0.2534 -0.5016 3069424 PK04_102266 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 5503560.0 153000.0 0.17 4745960.0 -448000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N13 mock treatment 4587840.0 -54312.5 -0.0600538931982102 -0.5015 -0.7125 5243360.0 -107000.0 -0.12 4505200.0 -689000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N14 mock treatment 4363160.0 -278992.5 -0.308484893866084 -0.2417 -0.5427 5501240.0 151000.0 0.17 4919600.0 -275000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N15 compound treatment 2349280.0 -2292872.5 -2.53525284662119 -3.6198 -0.9689 3189268 PK04_102267 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 4127400.0 -1220000.0 -1.34 2807440.0 -2390000.0 -2.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N16 compound treatment 4448640.0 -193512.5 -0.21396877344108 -1.1358 -0.6607 3069404 PK04_102268 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 3793320.0 -1560000.0 -1.71 5146160.0 -48000.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N17 compound treatment 2560360.0 -2081792.5 -2.3018595066667 -2.5571 -0.86 3069428 PK04_102269 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 5109320.0 -241000.0 -0.26 3337520.0 -1860000.0 -1.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N18 compound treatment 4188480.0 -453672.5 -0.50163037720534 0.0828 0.0724 3189269 PK04_102270 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 6239560.0 889000.0 0.97 4866520.0 -328000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N19 compound treatment 4038960.0 -603192.5 -0.666956188224836 -0.9286 -0.8904 3070277 PK04_102271 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 5208920.0 -141000.0 -0.15 4410400.0 -784000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N20 compound treatment 4348920.0 -293232.5 -0.324230209201274 -0.4713 -0.6193 3069270 PK04_102272 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 5509200.0 159000.0 0.17 4530440.0 -664000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N21 compound treatment 1918120.0 -2724032.5 -3.01199091964932 -5.6641 -0.9983 3070278 PK04_102273 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 2183560.0 -3170000.0 -3.47 1875480.0 -3320000.0 -3.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N22 compound treatment 4458200.0 -183952.5 -0.203398182527848 -0.9858 -0.878 3070279 PK04_102274 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 4855240.0 -495000.0 -0.54 4235680.0 -958000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N23 compound treatment 2653120.0 -1989032.5 -2.19929381491865 -4.1358 -0.9968 3070280 PK04_102275 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 3238120.0 -2110000.0 -2.31 2552560.0 -2640000.0 -2.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 N24 compound treatment 4116600.0 -525552.5 -0.58110883691696 -1.3169 -0.977 3189270 PK04_102276 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 4694320.0 -656000.0 -0.72 4216240.0 -978000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O01 compound treatment 3393360.0 -1248792.5 -1.38080278797194 -2.1959 -0.9779 3189271 PK04_102277 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 4533720.0 -817000.0 -0.89 3671160.0 -1520000.0 -1.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O02 compound treatment 1346640.0 -3295512.5 -3.64388226850848 -6.4808 -0.9992 3070281 PK04_102278 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1739280.0 -3610000.0 -3.95 1580400.0 -3610000.0 -3.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O03 compound treatment 4036960.0 -605192.5 -0.669167608917981 -1.5721 -0.983 3189272 PK04_102279 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 4428920.0 -921000.0 -1.01 4153040.0 -1040000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O04 compound treatment 1818920.0 -2823232.5 -3.1216773860293 -6.1103 -0.9963 3189273 PK04_102280 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1832680.0 -3520000.0 -3.85 1597560.0 -3600000.0 -3.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O05 compound treatment 1586320.0 -3055832.5 -3.37886561264202 -6.322 -0.9976 3070282 PK04_102281 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1707320.0 -3640000.0 -3.99 1625200.0 -3570000.0 -3.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O06 compound treatment 323120.0 -4319032.5 -4.7755989224322 -8.7695 -0.998 3189274 PK04_102282 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 320880.0 -5030000.0 -5.51 305880.0 -4890000.0 -4.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O07 compound treatment 1056480.0 -3585672.5 -3.96471518266991 -7.4792 -0.9943 3070283 PK04_102283 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 812320.0 -4540000.0 -4.97 1188440.0 -4010000.0 -4.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O08 compound treatment 2185680.0 -2456472.5 -2.71614705932042 -4.9285 -0.9993 3189275 PK04_102284 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 2758640.0 -2590000.0 -2.84 2222640.0 -2970000.0 -2.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O09 compound treatment 1445520.0 -3196632.5 -3.53454962943941 -6.2796 -0.9994 3189276 PK04_102285 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1874000.0 -3480000.0 -3.81 1671640.0 -3520000.0 -3.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O10 compound treatment 2322960.0 -2319192.5 -2.56435514294297 -4.2822 -0.9934 3070284 PK04_102286 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 3444600.0 -1910000.0 -2.09 2438400.0 -2760000.0 -2.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O11 mock treatment 4392600.0 -249552.5 -0.275932781262994 0.0814 0.1233 5878080.0 528000.0 0.58 5033680.0 -160000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O12 mock treatment 4587200.0 -54952.5 -0.0607615478200165 0.2799 0.4885 5870160.0 520000.0 0.57 5170520.0 -23600.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O13 compound treatment 2654120.0 -1988032.5 -2.19818810457208 -4.1746 -0.9975 3189277 PK04_102287 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4ccccc43 3143000.0 -2210000.0 -2.42 2588360.0 -2610000.0 -2.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O14 compound treatment 2025360.0 -2616792.5 -2.8934145420829 -5.3031 -0.9991 3189278 PK04_102288 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 2544480.0 -2810000.0 -3.07 1986560.0 -3210000.0 -3.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O15 compound treatment 252160.0 -4389992.5 -4.85406012862498 -7.4815 -0.9946 3070285 PK04_102289 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 1927560.0 -3420000.0 -3.75 853760.0 -4340000.0 -4.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O16 compound treatment 2678280.0 -1963872.5 -2.17147414259889 -4.4126 -0.9945 3189279 PK04_102290 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 2899800.0 -2450000.0 -2.68 2416360.0 -2780000.0 -2.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O17 compound treatment 1811160.0 -2830992.5 -3.1302576983187 -5.7481 -0.9992 3070286 PK04_102291 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 2202600.0 -3150000.0 -3.45 1827600.0 -3370000.0 -3.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O18 compound treatment 1371800.0 -3270352.5 -3.61606259618872 -6.021 -0.9993 3189280 PK04_102292 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 2336920.0 -3010000.0 -3.3 1694080.0 -3500000.0 -3.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O19 compound treatment 2193040.0 -2449112.5 -2.70800903116965 -5.9851 -0.9885 3189281 PK04_102293 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1837880.0 -3510000.0 -3.85 1395720.0 -3800000.0 -3.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O20 compound treatment 931440.0 -3710712.5 -4.10297320440532 -6.4362 -0.9942 3070287 PK04_102294 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 2464240.0 -2890000.0 -3.16 1323640.0 -3870000.0 -3.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O21 compound treatment 1380000.0 -3262152.5 -3.60699577134683 -6.6195 -0.999 3189282 PK04_102295 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 1675080.0 -3680000.0 -4.02 1374360.0 -3820000.0 -3.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O22 compound treatment 453320.0 -4188832.5 -4.63163543530848 -8.2954 -0.9995 3070288 PK04_102296 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 790320.0 -4560000.0 -4.99 468280.0 -4730000.0 -4.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O23 compound treatment 1282080.0 -3360072.5 -3.71526692848319 -8.2334 -0.9874 3189283 PK04_102297 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 306120.0 -5040000.0 -5.52 190680.0 -5000000.0 -5.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 O24 compound treatment 1284560.0 -3357592.5 -3.71252476682369 -6.8324 -0.9972 3189284 PK04_102298 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1364600.0 -3990000.0 -4.36 1450800.0 -3740000.0 -3.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P01 compound treatment 1025800.0 -3616352.5 -3.99863837610275 -7.2601 -0.9993 3070289 PK04_102299 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1347960.0 -4000000.0 -4.38 1015960.0 -4180000.0 -4.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P02 compound treatment 4217840.0 -424312.5 -0.469166721429976 -1.1888 -0.9759 3069953 PK04_102300 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 4622440.0 -728000.0 -0.8 4404240.0 -790000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P03 compound treatment 2891680.0 -1750472.5 -1.93551555464035 -4.1708 -0.9893 3189285 PK04_102301 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 2803600.0 -2550000.0 -2.79 2703520.0 -2490000.0 -2.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P04 compound treatment 3950520.0 -691632.5 -0.764745211275694 -1.1921 -0.9299 3070290 PK04_102302 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 5055120.0 -295000.0 -0.32 4220800.0 -973000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P05 compound treatment 2284800.0 -2357352.5 -2.60654904976817 -5.6035 -0.9834 3189394 PK04_102303 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 1663200.0 -3690000.0 -4.04 2143920.0 -3050000.0 -3.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P06 compound treatment 4118560.0 -523592.5 -0.578941644637678 -0.8095 -0.9852 3069907 PK04_102304 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 4952040.0 -398000.0 -0.44 4808440.0 -386000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P07 compound treatment 2984960.0 -1657192.5 -1.83237489351208 -3.1458 -0.9996 3189395 PK04_102305 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 3644720.0 -1710000.0 -1.87 3451880.0 -1740000.0 -1.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P08 compound treatment 4334080.0 -308072.5 -0.340638950744407 -0.8711 -0.7843 3069314 PK04_102306 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 5243000.0 -107000.0 -0.12 4147240.0 -1050000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P09 compound treatment 2326560.0 -2315592.5 -2.56037458569531 -4.4939 -0.9999 3070291 PK04_102307 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 2934800.0 -2420000.0 -2.65 2625280.0 -2570000.0 -2.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P10 compound treatment 3759840.0 -882312.5 -0.975582060160108 -1.7314 -0.9551 3189396 PK04_102308 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 4772760.0 -578000.0 -0.63 3808360.0 -1390000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P11 mock treatment 4082600.0 -559552.5 -0.61870298870042 -1.173 -0.8405 5191200.0 -159000.0 -0.17 3959720.0 -1230000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P12 mock treatment 4010000.0 -632152.5 -0.698977559861572 -1.2588 -0.9095 5044920.0 -305000.0 -0.33 4051400.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P13 compound treatment 1616520.0 -3025632.5 -3.34547316017554 -5.3756 -0.9983 3189397 PK04_102309 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 2684520.0 -2670000.0 -2.92 2159080.0 -3040000.0 -3.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P14 compound treatment 4138200.0 -503952.5 -0.557225493430997 -1.784 -0.9499 3070292 PK04_102310 OCCOc1ccc(cc1)[C@H](O)CC=C 4132680.0 -1220000.0 -1.33 3999040.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P15 compound treatment 2546200.0 -2095952.5 -2.31751636517416 -2.4143 -0.9054 3070293 PK04_102311 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 4532760.0 -818000.0 -0.9 4228720.0 -965000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P16 compound treatment 4072520.0 -569632.5 -0.629848548993869 -1.3084 -0.9884 3070292 PK04_102312 OCCOc1ccc(cc1)[C@H](O)CC=C 4687240.0 -663000.0 -0.73 4287200.0 -907000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P17 compound treatment 2976920.0 -1665232.5 -1.84126480469852 -2.4082 -0.9747 3189398 PK04_102313 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 4289280.0 -1060000.0 -1.16 4030320.0 -1160000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P18 compound treatment 4034560.0 -607592.5 -0.671821313749755 -1.7129 -0.97 3070294 PK04_102314 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 4420880.0 -929000.0 -1.02 3921440.0 -1270000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P19 compound treatment 3418080.0 -1224072.5 -1.35346962820467 -2.1754 -0.919 3189399 PK04_102315 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 4845360.0 -505000.0 -0.55 3339280.0 -1850000.0 -1.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P20 compound treatment 4349000.0 -293152.5 -0.324141752373548 -1.4105 -0.9142 3070290 PK04_102316 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 4495520.0 -855000.0 -0.94 4015560.0 -1180000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P21 compound treatment 1791960.0 -2850192.5 -3.15148733697289 -5.7942 -0.9976 3189400 PK04_102317 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 2000800.0 -3350000.0 -3.67 1989360.0 -3200000.0 -3.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P22 compound treatment 4795920.0 153767.5 0.170022315716562 -1.2931 -0.7463 3070295 PK04_102318 COc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 4420520.0 -930000.0 -1.02 3807560.0 -1390000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P23 compound treatment 1351400.0 -3290752.5 -3.6386190872588 -6.2043 -0.9911 3189401 PK04_102319 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 2641560.0 -2710000.0 -2.97 1067760.0 -4130000.0 -4.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2102 P24 compound treatment 3395440.0 -1246712.5 -1.37850291045107 -2.5732 -0.9969 3414053 PK04_102320 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NO 4046120.0 -1300000.0 -1.43 3549760.0 -1640000.0 -1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A01 compound treatment 2438160.0 -2934589.20634921 -3.24480564839983 -5.1004 -0.9966 3070297 PK04_103001 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 2439720.0 -2690000.0 -2.94 2857040.0 -2640000.0 -2.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A02 compound treatment 2952040.0 -2420709.20634921 -2.67660321550324 -4.2208 -0.9973 3189402 PK04_103002 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 2946360.0 -2180000.0 -2.39 3256000.0 -2240000.0 -2.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A03 compound treatment 4741920.0 -630829.20634921 -0.697514380380339 -1.0162 -0.9463 3070298 PK04_103003 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 4846640.0 -279000.0 -0.31 4741240.0 -755000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A04 compound treatment 4742440.0 -630309.20634921 -0.696939411000122 -1.2639 -0.9994 3189403 PK04_103004 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 4432080.0 -693000.0 -0.76 4765440.0 -730000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A05 compound treatment 4395520.0 -977229.20634921 -1.080532444433 -1.1991 -0.9271 3070299 PK04_103005 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 4731640.0 -394000.0 -0.43 4932720.0 -563000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A06 compound treatment 4308960.0 -1063789.20634921 -1.1762427320323 -1.3299 -0.9294 3189404 PK04_103006 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccc(OCCO)cc3)/C(=C)C(C)C 4720200.0 -405000.0 -0.44 4814840.0 -681000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A07 compound treatment 4626320.0 -746429.20634921 -0.825334496444102 -1.2683 -0.9713 3070300 PK04_103007 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 4685960.0 -439000.0 -0.48 4608760.0 -887000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A08 compound treatment 4181200.0 -1191549.20634921 -1.31750828591038 -1.4518 -0.8667 3189405 PK04_103008 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 4962840.0 -163000.0 -0.18 4480400.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A09 compound treatment 4943600.0 -429149.20634921 -0.47451471768363 -0.6939 -0.9809 3189406 PK04_103009 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 4726400.0 -399000.0 -0.44 5206480.0 -289000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A10 compound treatment 4421280.0 -951469.20634921 -1.05204934590529 -1.3709 -0.9681 3070355 PK04_103010 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 4621920.0 -503000.0 -0.55 4727520.0 -768000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A11 compound treatment 4694960.0 -677789.20634921 -0.749438538255376 -1.0815 -0.9682 3189407 PK04_103011 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 4763120.0 -362000.0 -0.4 4771280.0 -725000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A12 compound treatment 4085320.0 -1287429.20634921 -1.42352379393974 -2.0346 -0.9797 3189408 PK04_103012 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccc(CO)o2)/C(=C)C(C)C 4349640.0 -776000.0 -0.85 4249240.0 -1250000.0 -1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A13 mock treatment 4993720.0 -379029.20634921 -0.419096515113424 -1.1984 -0.8976 4681920.0 -443000.0 -0.49 4329040.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A14 mock treatment 4765400.0 -607349.20634921 -0.671552301442821 -0.7813 -0.9166 4948320.0 -177000.0 -0.19 5009800.0 -486000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A15 compound treatment 3431440.0 -1941309.20634921 -2.14652567535646 -4.1916 -0.9931 3070356 PK04_103013 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 2555760.0 -2570000.0 -2.81 3204560.0 -2290000.0 -2.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A16 compound treatment 5077040.0 -295709.20634921 -0.326968729037017 -0.7625 -0.9332 3189409 PK04_103014 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 4838760.0 -287000.0 -0.31 4818480.0 -677000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A17 compound treatment 4564440.0 -808309.20634921 -0.893755852689998 -1.398 -0.965 3070357 PK04_103015 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 4663320.0 -462000.0 -0.51 4477760.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A18 compound treatment 4591520.0 -781229.20634921 -0.863813216504819 -1.4922 -0.9882 3189410 PK04_103016 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 4489120.0 -636000.0 -0.7 4475480.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A19 compound treatment 3056280.0 -2316469.20634921 -2.56134396897654 -4.3947 -0.9997 3070358 PK04_103017 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 2882080.0 -2240000.0 -2.46 2911320.0 -2580000.0 -2.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A20 compound treatment 4573200.0 -799549.20634921 -0.884069830054025 -1.4286 -0.9975 3189411 PK04_103018 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccccc2OCCO)/C(=C)C(C)C 4445720.0 -680000.0 -0.74 4652800.0 -843000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A21 compound treatment 4721280.0 -651469.20634921 -0.720336241933592 -1.2983 -0.9944 3070359 PK04_103019 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 4513960.0 -611000.0 -0.67 4640040.0 -856000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A22 compound treatment 4283000.0 -1089749.20634921 -1.20494697262932 -2.2142 -0.9855 3189412 PK04_103020 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 3685520.0 -1440000.0 -1.58 4446200.0 -1050000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A23 compound treatment 4435200.0 -937549.20634921 -1.03665785788101 -1.6652 -0.9797 3070360 PK04_103021 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 4493400.0 -632000.0 -0.69 4344520.0 -1150000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 A24 compound treatment 4297560.0 -1075189.20634921 -1.18884782998322 -1.5704 -0.9599 3189413 PK04_103022 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 4621000.0 -504000.0 -0.55 4520440.0 -975000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B01 compound treatment 4714600.0 -658149.20634921 -0.727722387048696 -1.4589 -0.9954 3189525 PK04_103023 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 4311840.0 -814000.0 -0.89 4590880.0 -905000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B02 compound treatment 3749600.0 -1623149.20634921 -1.794732871491 -2.8562 -0.9974 3070361 PK04_103024 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 3617960.0 -1510000.0 -1.65 3999680.0 -1500000.0 -1.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B03 compound treatment 4626440.0 -746309.20634921 -0.825201811202513 -1.7225 -0.9817 3189526 PK04_103025 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 3971120.0 -1150000.0 -1.26 4604880.0 -891000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B04 compound treatment 4667960.0 -704789.20634921 -0.77929271761283 -0.4696 -0.5756 3189527 PK04_103026 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1 5264920.0 140000.0 0.15 5309640.0 -186000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B05 compound treatment 5017000.0 -355749.20634921 -0.39335557824522 -0.4758 -0.9383 3070362 PK04_103027 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 4992080.0 -133000.0 -0.15 5212040.0 -284000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B06 compound treatment 3642360.0 -1730389.20634921 -1.91330924905742 -1.3632 -0.7018 3189528 PK04_103028 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 4850000.0 -275000.0 -0.3 5350080.0 -146000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B07 compound treatment 5211960.0 -160789.20634921 -0.177786289077476 0.1821 0.4326 3070363 PK04_103029 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 5450600.0 325000.0 0.36 5632360.0 137000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B08 compound treatment 5704160.0 331410.79365079 0.36644434350543 0.3316 0.8094 3189529 PK04_103030 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3c5ccc(CO)cc5)C1=O 5149720.0 24300.0 0.03 5676440.0 181000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B09 compound treatment 4619840.0 -752909.20634921 -0.832499499489891 -0.9897 -0.9299 3189530 PK04_103031 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 4868760.0 -257000.0 -0.28 4897200.0 -599000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B10 compound treatment 5058320.0 -314429.20634921 -0.347667626724851 0.0726 0.1271 3070364 PK04_103032 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4ccc(CN5CCCC5)cc4)C1=O 5538600.0 413000.0 0.45 5516600.0 20800.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B11 compound treatment 4991320.0 -381429.20634921 -0.421750219945198 -0.7878 -0.9984 3189531 PK04_103033 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 4683600.0 -442000.0 -0.48 5038480.0 -457000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B12 compound treatment 5457000.0 84250.7936507901 0.0931569742466099 0.4656 0.799 3189532 PK04_103034 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4cccs4 5272440.0 147000.0 0.16 6046080.0 550000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B13 mock treatment 5688160.0 315410.79365079 0.348752977960272 0.5066 0.9872 5395120.0 270000.0 0.3 5728280.0 232000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B14 mock treatment 5686960.0 314210.79365079 0.347426125544385 0.6497 0.9616 5598200.0 473000.0 0.52 5754920.0 259000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B15 compound treatment 5208840.0 -163909.20634921 -0.181236105358782 -0.5632 -0.9463 3070365 PK04_103035 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 4712920.0 -412000.0 -0.45 5154560.0 -341000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B16 compound treatment 5628520.0 255770.79365079 0.282808412890698 0.5172 0.9904 3189533 PK04_103036 CC1C=C(CCCO)C/C(=N/P(=O)(Oc2ccccc2)Oc3ccccc3)/N1Cc4cccc(OC(F)(F)F)c4 5450120.0 325000.0 0.36 5752200.0 256000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B17 compound treatment 5215520.0 -157229.20634921 -0.173849960243679 -0.2286 -0.5975 3070366 PK04_103037 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 5219280.0 93900.0 0.1 5172120.0 -324000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B18 compound treatment 5283920.0 -88829.2063492099 -0.0982193725381308 0.1247 0.3026 3189534 PK04_103038 CN1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 5053840.0 -71600.0 -0.08 5887000.0 391000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B19 compound treatment 5314640.0 -58109.2063492099 -0.0642519506914285 -0.0474 -0.225 3189535 PK04_103039 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 5246640.0 121000.0 0.13 5345640.0 -150000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B20 compound treatment 4963360.0 -409389.20634921 -0.45266588123536 -0.1746 -0.3 3070367 PK04_103040 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C)C3=O 5420000.0 295000.0 0.32 5324080.0 -172000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B21 compound treatment 5284920.0 -87829.2063492099 -0.0971136621915585 -0.1427 -0.6387 3189536 PK04_103041 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 5167280.0 41900.0 0.05 5300600.0 -195000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B22 compound treatment 5263720.0 -109029.20634921 -0.120554721538892 -0.5038 -0.9154 3189537 PK04_103042 CN1C(=O)C2C(C3C(N(C)C2C=C3c4ccc(CO)cc4)c5cccs5)C1=O 4733840.0 -392000.0 -0.43 5173640.0 -322000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B23 compound treatment 5173560.0 -199189.20634921 -0.220245566385854 -0.3006 -0.7704 3070368 PK04_103043 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 4831840.0 -294000.0 -0.32 5516720.0 20900.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 B24 compound treatment 4055480.0 -1317269.20634921 -1.45651819068146 -1.6397 -0.9305 3189538 PK04_103044 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 4598720.0 -527000.0 -0.58 4691960.0 -804000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C01 compound treatment 4765320.0 -607429.20634921 -0.671640758270547 -1.2709 -0.9941 3070369 PK04_103045 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 4501520.0 -624000.0 -0.68 4652400.0 -843000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C02 compound treatment 4369120.0 -1003629.20634921 -1.10972319758251 -1.2257 -0.8976 3189539 PK04_103046 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 4886320.0 -239000.0 -0.26 4747120.0 -749000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C03 compound treatment 4908840.0 -463909.20634921 -0.512949209330484 -0.3507 -0.5586 3189540 PK04_103047 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 5311920.0 187000.0 0.2 5198200.0 -298000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C04 compound treatment 5560320.0 187570.79365079 0.207398967254464 0.7052 0.9347 3070370 PK04_103048 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 5659160.0 534000.0 0.58 5923840.0 428000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C05 compound treatment 5441880.0 69130.7936507901 0.0764386338064361 0.4566 0.879 3189541 PK04_103049 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 5391040.0 266000.0 0.29 5917720.0 422000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C06 compound treatment 5729280.0 356530.79365079 0.394219787411327 0.6708 0.9283 3189542 PK04_103050 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 5302520.0 177000.0 0.19 6067440.0 572000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C07 compound treatment 5761360.0 388610.79365079 0.429690975329367 0.8077 0.9938 3070371 PK04_103051 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 5618640.0 493000.0 0.54 5923320.0 428000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C08 compound treatment 5419360.0 46610.7936507901 0.051538036801627 0.6212 0.8451 3189543 PK04_103052 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccc(CO)o3)/C(=C)C(C)C 5666600.0 541000.0 0.59 5926040.0 430000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C09 compound treatment 5474320.0 101570.79365079 0.112307877449243 -0.0619 -0.2198 3070372 PK04_103053 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 5158560.0 33200.0 0.04 5240800.0 -255000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C10 compound treatment 5303320.0 -69429.2063492099 -0.0767685918146274 0.0788 0.1379 3189544 PK04_103054 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 5574920.0 450000.0 0.49 5217680.0 -278000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C11 mock treatment 5965280.0 592530.79365079 0.655167429202399 0.7067 0.9152 5338360.0 213000.0 0.23 5830240.0 334000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C12 mock treatment 5360200.0 -12549.2063492099 -0.0138757873015927 0.3828 0.7994 5438240.0 313000.0 0.34 5828920.0 333000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C13 compound treatment 5943920.0 571170.79365079 0.631549456199614 1.1173 0.9886 3189545 PK04_103055 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 5829760.0 704000.0 0.77 6026280.0 530000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C14 compound treatment 4649120.0 -723629.20634921 -0.800124300542253 -0.119 -0.1314 3189546 PK04_103056 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 5438520.0 313000.0 0.34 5745960.0 250000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C15 mock treatment 5485760.0 113010.79365079 0.12495720381403 0.4253 0.908 5321240.0 196000.0 0.21 5891560.0 396000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C16 mock treatment 5755280.0 382530.79365079 0.422968256422208 0.6684 0.992 5414440.0 289000.0 0.32 5912480.0 417000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C17 compound treatment 5600440.0 227690.79365079 0.251760066358946 0.609 0.9663 3070427 PK04_103057 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 5560880.0 435000.0 0.48 5820800.0 325000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C18 compound treatment 5050440.0 -322309.20634921 -0.356380624255841 -0.4722 -0.7704 3189660 PK04_103058 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccccc3OCCO)/C(=C)C(C)C 5158160.0 32800.0 0.04 5000240.0 -496000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C19 compound treatment 4921480.0 -451269.20634921 -0.49897303054981 -0.7256 -0.9513 3070428 PK04_103059 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 4917320.0 -208000.0 -0.23 4967800.0 -528000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C20 compound treatment 5541600.0 168850.79365079 0.18670006956663 -0.4203 -0.6131 3189661 PK04_103060 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 4791320.0 -334000.0 -0.37 4948960.0 -547000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C21 compound treatment 5465960.0 93210.7936507901 0.103064138951898 -0.0948 -0.2188 3189662 PK04_103061 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 4760720.0 -365000.0 -0.4 5627480.0 132000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C22 compound treatment 4723880.0 -648869.20634921 -0.717461395032504 -0.7286 -0.8393 3070429 PK04_103062 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 5071120.0 -54300.0 -0.06 5012480.0 -483000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C23 compound treatment 5347160.0 -25589.2063492099 -0.028294250220896 0.0217 0.126 3189663 PK04_103063 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 5261000.0 136000.0 0.15 5413480.0 -82300.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 C24 compound treatment 4498880.0 -873869.20634921 -0.966246223011281 -1.8426 -0.9612 3189664 PK04_103064 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3cccc(OCCO)c3)/C(=C)C(C)C 3776600.0 -1350000.0 -1.48 4750360.0 -745000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D01 compound treatment 4794720.0 -578029.20634921 -0.63913287408132 -1.0816 -0.9756 3070430 PK04_103065 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 4718600.0 -407000.0 -0.45 4709840.0 -786000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D02 compound treatment 3752440.0 -1620309.20634921 -1.79159265410674 -2.1485 -0.9493 3189665 PK04_103066 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5ccc(CN6CCCC6)cc5 4389520.0 -736000.0 -0.81 4376040.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D03 compound treatment 5511160.0 138410.79365079 0.153042246616968 0.1249 0.6087 3070431 PK04_103067 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 5237760.0 112000.0 0.12 5436320.0 -59500.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D04 compound treatment 5381560.0 8810.79365079012 0.00974218570119252 -0.3852 -0.7864 3189666 PK04_103068 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 4749480.0 -376000.0 -0.41 5231560.0 -264000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D05 compound treatment 4621880.0 -750869.20634921 -0.830243850382883 -0.982 -0.9468 3189667 PK04_103069 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 4672400.0 -453000.0 -0.5 5122560.0 -373000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D06 compound treatment 5008440.0 -364309.20634921 -0.402820458811879 -0.2268 -0.5497 3189668 PK04_103070 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 5187160.0 61800.0 0.07 5438440.0 -57400.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D07 compound treatment 5781280.0 408530.79365079 0.451716725433088 -0.0764 -0.1134 3070432 PK04_103071 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 4677200.0 -448000.0 -0.49 5402920.0 -92900.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D08 compound treatment 5440520.0 67770.7936507901 0.0749348677350977 0.3779 0.7996 3189669 PK04_103072 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 5245960.0 121000.0 0.13 5941760.0 446000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D09 compound treatment 5240000.0 -132749.20634921 -0.146782170959588 0.0555 0.1876 3070433 PK04_103073 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 5359720.0 234000.0 0.26 5482160.0 -13600.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D10 compound treatment 5513280.0 140530.79365079 0.155386352551701 0.716 0.9118 3189670 PK04_103074 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 5662080.0 537000.0 0.59 5991120.0 495000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D11 mock treatment 5954280.0 581530.79365079 0.643004615390103 0.7205 0.9215 5322640.0 197000.0 0.22 5883400.0 388000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D12 mock treatment 6092080.0 719330.79365079 0.795371501147772 0.8551 0.9163 5402320.0 277000.0 0.3 5876800.0 381000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D13 compound treatment 5001480.0 -371269.20634921 -0.410516202824023 -0.2859 -0.5852 3189671 PK04_103075 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 5253240.0 128000.0 0.14 5272000.0 -224000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D14 compound treatment 5815200.0 442450.79365079 0.489222420388822 1.1842 0.9489 3070434 PK04_103076 NC(=O)N1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 5635920.0 511000.0 0.56 6495000.0 999000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D15 mock treatment 5664240.0 291490.79365079 0.322304386470262 0.8364 0.8757 5909040.0 784000.0 0.86 5763120.0 267000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D16 mock treatment 5868640.0 495890.79365079 0.548311581309648 0.8528 0.9895 5482480.0 357000.0 0.39 6031640.0 536000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D17 compound treatment 5209400.0 -163349.20634921 -0.180616907564702 -0.1292 -0.3789 3189672 PK04_103077 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 4919920.0 -205000.0 -0.23 5676960.0 181000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D18 compound treatment 4964840.0 -407909.20634921 -0.451029429922433 -0.737 -0.9901 3189673 PK04_103078 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 4812840.0 -313000.0 -0.34 5014360.0 -481000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D19 compound treatment 5760320.0 387570.79365079 0.428541036568932 0.6772 0.9907 3070435 PK04_103079 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 5517640.0 392000.0 0.43 5809600.0 314000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D20 compound treatment 4938960.0 -433789.20634921 -0.479645213691725 -0.452 -0.7969 3189674 PK04_103080 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)CC2)c4cccs4 4848920.0 -276000.0 -0.3 5495320.0 -478.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D21 compound treatment 5541000.0 168250.79365079 0.186036643358686 0.0999 0.1734 3189675 PK04_103081 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 5471280.0 346000.0 0.38 5105360.0 -390000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D22 compound treatment 4930600.0 -442149.20634921 -0.48888895218907 -0.4409 -0.8192 3070436 PK04_103082 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 4926400.0 -199000.0 -0.22 5439080.0 -56700.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D23 compound treatment 4927040.0 -445709.20634921 -0.492825281022868 -0.5454 -0.881 3189676 PK04_103083 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 4792680.0 -333000.0 -0.36 5408560.0 -87200.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 D24 compound treatment 5072760.0 -299989.20634921 -0.331701169320346 -0.852 -0.97 3070437 PK04_103084 CN1CCC(=CC1C2CC2)CCCO 4657560.0 -468000.0 -0.51 4866440.0 -629000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E01 mock treatment 5202080.0 -170669.20634921 -0.188710707301611 -0.6397 -0.8182 4453040.0 -672000.0 -0.74 5313520.0 -182000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E02 mock treatment 5166520.0 -206229.20634921 -0.228029767225724 -0.1346 -0.378 5299640.0 174000.0 0.19 5300600.0 -195000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E03 compound treatment 5138680.0 -234069.20634921 -0.258812743274298 -0.2059 -0.5728 3189677 PK04_103085 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 5235520.0 110000.0 0.12 5278120.0 -218000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E04 compound treatment 5528880.0 156130.79365079 0.17263543395823 0.4197 0.9782 3070438 PK04_103086 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 5361840.0 236000.0 0.26 5790080.0 294000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E05 compound treatment 5867640.0 494890.79365079 0.547205870963076 0.3043 0.5517 3189678 PK04_103087 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 5072200.0 -53200.0 -0.06 5533800.0 38000.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E06 compound treatment 5088360.0 -284389.20634921 -0.314452087913818 -0.5468 -0.9998 3189679 PK04_103088 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 4843120.0 -282000.0 -0.31 5173520.0 -322000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E07 compound treatment 5487920.0 115170.79365079 0.127345538162627 0.7369 0.8812 3189680 PK04_103089 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 5747800.0 622000.0 0.68 5961480.0 466000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E08 compound treatment 5314240.0 -58509.2063492099 -0.0646942348300574 0.1291 0.3447 3070490 PK04_103090 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 5455520.0 330000.0 0.36 5422800.0 -73000.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E09 mock treatment 5822320.0 449570.79365079 0.497095078056417 0.6652 0.9102 5250720.0 125000.0 0.14 6011720.0 516000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E10 mock treatment 5519200.0 146450.79365079 0.161932157803409 0.4691 0.8276 5609000.0 484000.0 0.53 5616360.0 121000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E11 compound treatment 3460160.0 -1912589.20634921 -2.1147696742029 -3.3362 -0.995 3187704 PK04_103091 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 3609880.0 -1520000.0 -1.66 3498880.0 -2000000.0 -2.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E12 compound treatment 4836960.0 -535789.20634921 -0.592427669042104 -0.9998 -0.9542 3070491 PK04_103092 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 4807200.0 -318000.0 -0.35 4707720.0 -788000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E13 compound treatment 3111760.0 -2260989.20634921 -2.49999915894871 -3.5425 -0.972 3187705 PK04_103093 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 3885240.0 -1240000.0 -1.36 3226200.0 -2270000.0 -2.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E14 compound treatment 4531000.0 -841749.20634921 -0.930730806679377 -0.3755 -0.3938 3187706 PK04_103094 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 5214080.0 88700.0 0.1 5678360.0 183000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E15 compound treatment 5703000.0 330250.79365079 0.365161719503406 1.1069 0.9518 3070492 PK04_103095 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 5755480.0 630000.0 0.69 6354720.0 859000.0 0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E16 compound treatment 5720080.0 347330.79365079 0.384047252222861 -0.2888 -0.258 3187707 PK04_103096 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 4175800.0 -950000.0 -1.04 5650840.0 155000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E17 mock treatment 5641480.0 268730.79365079 0.297138418982275 0.9818 0.9051 5558240.0 433000.0 0.47 6421800.0 926000.0 0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E18 mock treatment 5743880.0 371130.79365079 0.410363158471283 0.5664 0.8929 5558160.0 433000.0 0.47 5592200.0 96400.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E19 compound treatment 3651280.0 -1721469.20634921 -1.903446312766 -1.0531 -0.5431 3070493 PK04_103097 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 4925240.0 -200000.0 -0.22 5793320.0 298000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E20 compound treatment 5114960.0 -257789.20634921 -0.285040192694993 0.3115 0.4433 3187708 PK04_103098 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 5675880.0 550000.0 0.6 5716760.0 221000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E21 compound treatment 5114880.0 -257869.20634921 -0.285128649522719 -0.731 -0.884 3187709 PK04_103099 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 4452640.0 -673000.0 -0.74 5252440.0 -243000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E22 compound treatment 5180400.0 -192349.20634921 -0.2126825076153 0.0281 0.0967 3070494 PK04_103100 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 5290120.0 165000.0 0.18 5576440.0 80600.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E23 compound treatment 5713400.0 340650.79365079 0.376661107107758 0.1907 0.3636 3187710 PK04_103101 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 4869480.0 -256000.0 -0.28 5728920.0 233000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 E24 compound treatment 4721800.0 -650949.20634921 -0.719761272553375 -0.6407 -0.8211 3187711 PK04_103102 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 4868840.0 -257000.0 -0.28 5387200.0 -109000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F01 mock treatment 5063200.0 -309549.20634921 -0.342271760233578 -0.5716 -0.9446 4957480.0 -168000.0 -0.18 5033520.0 -462000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F02 mock treatment 5222240.0 -150509.20634921 -0.166419586714713 0.0056 0.0258 5244800.0 119000.0 0.13 5540960.0 45200.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F03 compound treatment 5489120.0 116370.79365079 0.128672390578513 0.5578 0.9093 3070495 PK04_103103 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 5569160.0 444000.0 0.49 5845960.0 350000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F04 compound treatment 3956600.0 -1416149.20634921 -1.56585082975053 -0.8238 -0.5162 3187712 PK04_103104 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4ccc(CN5CCCC5)cc4 5000800.0 -125000.0 -0.14 5770320.0 275000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F05 compound treatment 5041680.0 -331069.20634921 -0.366066646891815 -0.6287 -0.8616 3070496 PK04_103105 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 5034520.0 -90900.0 -0.1 4874680.0 -621000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F06 compound treatment 5483280.0 110530.79365079 0.122215042154531 0.7711 0.8539 3187713 PK04_103106 CN1C(C2CC2)C3C4C(C1C=C3c5ccc(CO)cc5)C(=O)N(C(=O)N)C4=O 5515640.0 390000.0 0.43 6279080.0 783000.0 0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F07 compound treatment 5402640.0 29890.7936507901 0.0330505598069375 -0.1289 -0.3528 3070497 PK04_103107 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 4804760.0 -321000.0 -0.35 5590360.0 94600.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F08 compound treatment 4895920.0 -476829.20634921 -0.527234987008199 -0.2386 -0.4013 3187714 PK04_103108 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)CC1 5347120.0 222000.0 0.24 5367440.0 -128000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F09 mock treatment 5738280.0 365530.79365079 0.404171180530478 0.4816 0.92 5408840.0 283000.0 0.31 5614920.0 119000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F10 mock treatment 5777920.0 405170.79365079 0.448001538668605 0.8051 0.9979 5588480.0 463000.0 0.51 5933640.0 438000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F11 compound treatment 5991320.0 618570.79365079 0.683960126627143 0.4664 0.6763 3187715 PK04_103109 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 5173600.0 48200.0 0.05 5566600.0 70800.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F12 compound treatment 5642200.0 269450.79365079 0.297934530431807 -0.2575 -0.3957 3070498 PK04_103110 CC1C=C(CCCO)CCN1Cc2cccc(OC(F)(F)F)c2 4630200.0 -495000.0 -0.54 5294920.0 -201000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F13 compound treatment 4363000.0 -1009749.20634921 -1.11649014490353 -0.9846 -0.7189 3187716 PK04_103111 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 5292560.0 167000.0 0.18 4726520.0 -769000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F14 compound treatment 5586240.0 213490.79365079 0.236058979437619 0.3253 0.887 3070499 PK04_103112 CN1CCC(=CC1c2cccs2)c3ccc(CO)cc3 5377280.0 252000.0 0.28 5547080.0 51300.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F15 compound treatment 5241600.0 -131149.20634921 -0.145013034405072 0.086 0.1555 3187717 PK04_103113 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 4942200.0 -183000.0 -0.2 5988640.0 493000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F16 compound treatment 5863600.0 490850.79365079 0.542738801162924 0.7161 0.9428 3187718 PK04_103114 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4cccs4 5571520.0 446000.0 0.49 5704080.0 208000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F17 mock treatment 5489680.0 116930.79365079 0.129291588372594 0.5534 0.7785 5258280.0 133000.0 0.15 6177080.0 681000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F18 mock treatment 5754040.0 381290.79365079 0.421597175592458 0.5656 0.9204 5244520.0 119000.0 0.13 5921840.0 426000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F19 compound treatment 5084240.0 -288509.20634921 -0.319007614541696 0.1459 0.2761 3070500 PK04_103115 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 5310360.0 185000.0 0.2 5863560.0 368000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F20 compound treatment 5452880.0 80130.7936507901 0.0886014476187318 0.1167 0.5776 3187719 PK04_103116 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)CC1)c4ccc(CN5CCCC5)cc4 5072080.0 -53300.0 -0.06 5667080.0 171000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F21 compound treatment 4951280.0 -421469.20634921 -0.466022862221954 -0.3539 -0.7338 3070501 PK04_103117 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 5014440.0 -111000.0 -0.12 5470480.0 -25300.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F22 compound treatment 4891440.0 -481309.20634921 -0.532188569360843 -0.7378 -0.9178 3187720 PK04_103118 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)CC2 4973080.0 -152000.0 -0.17 4918920.0 -577000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F23 compound treatment 5187200.0 -185549.20634921 -0.205163677258608 -0.0596 -0.2613 3187721 PK04_103119 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 5216120.0 90700.0 0.1 5498440.0 2640.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 F24 compound treatment 5049760.0 -322989.20634921 -0.35713250729151 -0.567 -0.9961 3070502 PK04_103120 CN1C(C2C3C(C1C=C2c4ccc(CO)cc4)C(=O)N(C(=O)N)C3=O)c5cccs5 4862480.0 -263000.0 -0.29 5159920.0 -336000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G01 compound treatment 2592560.0 -2780189.20634921 -3.07408397088907 -5.3332 -0.9997 3187722 PK04_103121 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 2394320.0 -2730000.0 -2.99 2334720.0 -3160000.0 -3.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G02 compound treatment 4996240.0 -376509.20634921 -0.416310125040062 -0.7372 -0.9851 3187723 PK04_103122 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 4649600.0 -476000.0 -0.52 5157440.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G03 mock treatment 5404000.0 31250.7936507901 0.0345543258782758 0.3923 0.8515 5455760.0 330000.0 0.36 5777880.0 282000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G04 mock treatment 5779280.0 406530.79365079 0.449505304739944 0.729 0.9463 5337440.0 212000.0 0.23 6074640.0 579000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G05 compound treatment 5081760.0 -290989.20634921 -0.321749776201195 -0.7868 -0.9229 3070503 PK04_103123 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 4834360.0 -291000.0 -0.32 4776000.0 -720000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G06 compound treatment 5472400.0 99650.7936507901 0.110184913583824 0.0282 0.1635 3187724 PK04_103124 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 5016440.0 -109000.0 -0.12 5553560.0 57800.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G07 compound treatment 3914360.0 -1458389.20634921 -1.61255603478975 -3.4359 -0.991 3070504 PK04_103125 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 3087920.0 -2040000.0 -2.23 3395960.0 -2100000.0 -2.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G08 compound treatment 4642920.0 -729829.20634921 -0.806979704691001 -1.2267 -0.9933 3187725 PK04_103126 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 4474360.0 -651000.0 -0.71 4893200.0 -603000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G09 compound treatment 5842240.0 469490.79365079 0.519120828160138 0.4975 0.8291 3187726 PK04_103127 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 5397200.0 272000.0 0.3 5540560.0 44800.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G10 compound treatment 5128200.0 -244549.20634921 -0.270400587706376 -0.2604 -0.5738 3070543 PK04_103128 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 5263360.0 138000.0 0.15 5165200.0 -331000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G11 compound treatment 6202040.0 829290.79365079 0.916955410856866 0.866 0.8544 3187727 PK04_103129 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 5308320.0 183000.0 0.2 5877040.0 381000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G12 compound treatment 5971480.0 598730.79365079 0.662022833351148 0.674 0.8766 3187844 PK04_103130 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 5458640.0 333000.0 0.36 5635720.0 140000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G13 compound treatment 6400320.0 1027570.79365079 1.13619565837523 1.37 0.9285 3070544 PK04_103131 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 5915280.0 790000.0 0.87 5866240.0 370000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G14 compound treatment 4360120.0 -1012629.20634921 -1.11967459070166 -0.5674 -0.5016 3187845 PK04_103132 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 5271120.0 146000.0 0.16 5473120.0 -22700.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G15 compound treatment 5693400.0 320650.79365079 0.354546900176311 0.805 0.9483 3070545 PK04_103133 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 5449480.0 324000.0 0.35 6178120.0 682000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G16 compound treatment 5529640.0 156890.79365079 0.173475773821625 0.8557 0.908 3187846 PK04_103134 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 5695200.0 570000.0 0.62 6178040.0 682000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G17 compound treatment 5468560.0 95810.7936507901 0.105938985852986 0.8223 0.8665 3070546 PK04_103135 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 5819560.0 694000.0 0.76 6052000.0 556000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G18 compound treatment 5365840.0 -6909.20634920988 -0.00763958094692467 0.6933 0.7858 3187847 PK04_103136 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 5535360.0 410000.0 0.45 6252680.0 757000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G19 mock treatment 5931960.0 559210.79365079 0.618325160454609 0.9549 0.9671 5751480.0 626000.0 0.69 5844600.0 349000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G20 mock treatment 5849520.0 476770.79365079 0.527170399483185 0.8566 0.9741 5436280.0 311000.0 0.34 6109640.0 614000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G21 compound treatment 5516960.0 144210.79365079 0.159455366627087 0.7923 0.9072 3070547 PK04_103137 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 5651600.0 526000.0 0.58 6130120.0 634000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G22 compound treatment 4959880.0 -412869.20634921 -0.456513753241432 0.2127 0.2811 3187848 PK04_103138 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 5402120.0 277000.0 0.3 6015800.0 520000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G23 compound treatment 5423960.0 51210.7936507901 0.0566243043958598 0.1915 0.4815 3070548 PK04_103139 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 5471920.0 347000.0 0.38 5391680.0 -104000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 G24 compound treatment 4754480.0 -618269.20634921 -0.683626658427391 -0.6882 -0.8355 3187849 PK04_103140 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 5078120.0 -47300.0 -0.05 5040800.0 -455000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H01 compound treatment 1890000.0 -3482749.20634921 -3.85091183197693 -7.0994 -0.9983 3070549 PK04_103141 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 1450880.0 -3670000.0 -4.02 1090040.0 -4410000.0 -4.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H02 compound treatment 4884680.0 -488069.20634921 -0.539663171303672 -0.8374 -0.9795 3187850 PK04_103142 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)CC1 4811440.0 -314000.0 -0.34 4930840.0 -565000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H03 mock treatment 5484360.0 111610.79365079 0.123409209328829 0.1204 0.5385 5050320.0 -75100.0 -0.08 5662560.0 167000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H04 mock treatment 5661800.0 289050.79365079 0.319606453224625 0.3252 0.6769 5033520.0 -91900.0 -0.1 5838840.0 343000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H05 compound treatment 5716440.0 343690.79365079 0.380022466561338 0.5573 0.9399 3187851 PK04_103143 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 5515000.0 390000.0 0.43 5653880.0 158000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H06 compound treatment 5735240.0 362490.79365079 0.400809821076898 0.7786 0.869 3187852 PK04_103144 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4ccc(CN5CCCC5)cc4 5841800.0 716000.0 0.78 5658400.0 163000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H07 compound treatment 6058120.0 685370.79365079 0.757821577778175 0.7588 0.7995 3070550 PK04_103145 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 5111880.0 -13500.0 -0.01 6064960.0 569000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H08 compound treatment 5268600.0 -104149.20634921 -0.115158855047619 0.2249 0.5676 3187853 PK04_103146 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C(=O)N)C3=O 5273200.0 148000.0 0.16 5837360.0 342000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H09 compound treatment 5455040.0 82290.7936507901 0.0909897819673281 0.2625 0.5288 3070551 PK04_103147 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 5023640.0 -102000.0 -0.11 5969200.0 473000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H10 compound treatment 4896960.0 -475789.20634921 -0.526085048247764 -0.4057 -0.7248 3070552 PK04_103148 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)CC1 5138280.0 12900.0 0.01 5305760.0 -190000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H11 compound treatment 5554800.0 182050.79365079 0.201295446141385 0.8385 0.8921 3187854 PK04_103149 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 5855280.0 730000.0 0.8 5945840.0 450000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H12 compound treatment 6025080.0 652330.79365079 0.721288907927425 1.0709 0.9749 3070553 PK04_103150 CN1CCC(=CC1c2cccs2)CCCO 5507680.0 382000.0 0.42 6208160.0 712000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H13 compound treatment 5840440.0 467690.79365079 0.517130549536308 0.9023 0.9964 3187855 PK04_103151 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 5553320.0 428000.0 0.47 6070760.0 575000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H14 compound treatment 4842160.0 -530589.20634921 -0.586677975239928 -0.7667 -0.974 3187856 PK04_103152 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3cccs3 4770520.0 -355000.0 -0.39 5144400.0 -351000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H15 compound treatment 5407800.0 35050.7936507901 0.0387560251952507 0.9094 0.8231 3070554 PK04_103153 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 5699360.0 574000.0 0.63 6400320.0 905000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H16 compound treatment 6069480.0 696730.79365079 0.770382447315237 1.2227 0.9868 3187857 PK04_103154 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 5621600.0 496000.0 0.54 6296920.0 801000.0 0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H17 compound treatment 6002240.0 629490.79365079 0.696034483611713 1.0004 0.9836 3187858 PK04_103155 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 5671520.0 546000.0 0.6 5932880.0 437000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H18 compound treatment 4541960.0 -830789.20634921 -0.918612221280945 -1.0897 -0.8436 3070555 PK04_103156 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)CC2 5067960.0 -57400.0 -0.06 4593160.0 -903000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H19 mock treatment 5478800.0 106050.79365079 0.117261459801887 0.2453 0.9037 5193320.0 67900.0 0.07 5728160.0 232000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H20 mock treatment 5429640.0 56890.7936507901 0.0629047391643906 0.3616 0.855 5300440.0 175000.0 0.19 5866200.0 370000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H21 compound treatment 5540520.0 167770.79365079 0.185505902392332 0.5086 0.8781 3187859 PK04_103157 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 5285640.0 160000.0 0.18 6013800.0 518000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H22 compound treatment 5483960.0 111210.79365079 0.1229669251902 -0.1669 -0.4667 3070556 PK04_103158 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 4829560.0 -296000.0 -0.32 5408120.0 -87700.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H23 compound treatment 4877600.0 -495149.20634921 -0.547491600557404 -0.9937 -0.862 3187860 PK04_103159 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 4966320.0 -159000.0 -0.17 4499960.0 -996000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 H24 compound treatment 4826200.0 -546549.20634921 -0.604325112371222 -1.4092 -0.9536 3070597 PK04_103160 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 4521960.0 -603000.0 -0.66 4324400.0 -1170000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I01 compound treatment 4816240.0 -556509.20634921 -0.615337987423083 -1.1257 -0.9729 3187861 PK04_103161 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 4345640.0 -780000.0 -0.85 5017000.0 -479000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I02 compound treatment 4661320.0 -711429.20634921 -0.78663463431407 -1.2295 -0.9638 3187862 PK04_103162 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 4301240.0 -824000.0 -0.9 5056920.0 -439000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I03 compound treatment 5302720.0 -70029.2063492099 -0.0774320180225708 -0.3619 -0.5495 3070598 PK04_103163 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 5214320.0 88900.0 0.1 4851280.0 -645000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I04 compound treatment 5370960.0 -1789.20634920988 -0.00197834397247429 -0.0526 -0.1824 3187863 PK04_103164 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 5266520.0 141000.0 0.15 5252920.0 -243000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I05 mock treatment 4060640.0 -1312109.20634921 -1.45081272529314 -1.1005 -0.7365 4817200.0 -308000.0 -0.34 5378360.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I06 mock treatment 5490520.0 117770.79365079 0.130220385063715 0.4271 0.6715 5693760.0 568000.0 0.62 5483000.0 -12800.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I07 compound treatment 5444760.0 72010.7936507901 0.0796230796045644 0.2303 0.9609 3070599 PK04_103165 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)CCO 5263680.0 138000.0 0.15 5663000.0 167000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I08 compound treatment 5843120.0 470370.79365079 0.520093853265122 0.8553 0.9656 3187864 PK04_103166 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 5416960.0 292000.0 0.32 6135480.0 640000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I09 compound treatment 5551480.0 178730.79365079 0.197624487790765 0.1392 0.4092 3187865 PK04_103167 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)CCO 5323040.0 198000.0 0.22 5323520.0 -172000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I10 compound treatment 5338440.0 -34309.2063492099 -0.0379360444430068 0.1962 0.6913 3070600 PK04_103168 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 5354760.0 229000.0 0.25 5621960.0 126000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I11 compound treatment 5546440.0 173690.79365079 0.19205170764404 0.7229 0.8622 3187866 PK04_103169 COCC(=C=CC[C@H](O)c1ccccc1OCCO)CCO 5817880.0 692000.0 0.76 5796480.0 301000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I12 compound treatment 5470000.0 97250.7936507901 0.10753120875205 -0.1042 -0.2756 3187978 PK04_103170 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 5187560.0 62200.0 0.07 5140960.0 -355000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I13 compound treatment 5359320.0 -13429.2063492099 -0.0148488124065763 -0.267 -0.3643 3070601 PK04_103171 CCCCC(=C=CC[C@H](O)c1ccc(CO)o1)CCO 5347760.0 222000.0 0.24 4807160.0 -689000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I14 compound treatment 4575960.0 -796789.20634921 -0.881018069497485 -0.8811 -0.8433 3187979 PK04_103172 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 5042440.0 -83000.0 -0.09 4943520.0 -552000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I15 compound treatment 5122080.0 -250669.20634921 -0.277167535027398 0.2575 0.4162 3070602 PK04_103173 CC(C)C(=C=CC[C@H](O)c1ccc(CO)o1)CCO 5319360.0 194000.0 0.21 6004800.0 509000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I16 compound treatment 4355080.0 -1017669.20634921 -1.12524737084838 -0.7038 -0.5844 3187980 PK04_103174 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 4808800.0 -317000.0 -0.35 5747920.0 252000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I17 compound treatment 5438960.0 66210.7936507901 0.0732099595944449 0.7967 0.8585 3070603 PK04_103175 COCC(=C=CC[C@H](O)c1ccc(CO)o1)CCO 5751800.0 626000.0 0.69 6114360.0 619000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I18 compound treatment 5667440.0 294690.79365079 0.325842659579293 0.7282 0.9712 3187981 PK04_103176 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 5640240.0 515000.0 0.56 5866120.0 370000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I19 compound treatment 5270080.0 -102669.20634921 -0.113522403734692 0.043 0.1317 3070604 PK04_103177 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 5033280.0 -92100.0 -0.1 5783640.0 288000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I20 compound treatment 5292880.0 -79869.2063492099 -0.0883122078328426 0.2862 0.6393 3187982 PK04_103178 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 5487960.0 363000.0 0.4 5682040.0 186000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I21 mock treatment 5449880.0 77130.7936507901 0.0852843165790148 0.1864 0.9579 5202400.0 77000.0 0.08 5648520.0 153000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I22 mock treatment 5167880.0 -204869.20634921 -0.226526001154385 -0.429 -0.9982 4887920.0 -237000.0 -0.26 5240200.0 -256000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I23 compound treatment 3374600.0 -1998149.20634921 -2.20937425145563 -1.701 -0.749 3187983 PK04_103179 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 4831080.0 -294000.0 -0.32 5082680.0 -413000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 I24 compound treatment 4468920.0 -903829.20634921 -0.999373304994588 -1.5462 -0.9964 3070605 PK04_103180 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 4359440.0 -766000.0 -0.84 4658920.0 -837000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J01 compound treatment 4067680.0 -1305069.20634921 -1.44302852445327 -2.8867 -0.995 3187984 PK04_103181 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 3561080.0 -1560000.0 -1.71 3658560.0 -1840000.0 -1.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J02 compound treatment 4724560.0 -648189.20634921 -0.716709511996835 -1.1075 -0.9911 3187985 PK04_103182 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 4502600.0 -623000.0 -0.68 4978160.0 -518000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J03 compound treatment 4092120.0 -1280629.20634921 -1.41600496358305 -1.6769 -0.9499 3070606 PK04_103183 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 4406720.0 -719000.0 -0.79 4796920.0 -699000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J04 compound treatment 5444320.0 71570.7936507901 0.0791365670520726 -0.3027 -0.5093 3187986 PK04_103184 CN1CCC(=CC1c2ccc(CN3CCCC3)cc2)CCCO 4587760.0 -538000.0 -0.59 5481240.0 -14600.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J05 mock treatment 5456320.0 83570.7936507901 0.0924050912109407 -0.075 -0.3389 5104800.0 -20600.0 -0.02 5296840.0 -199000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J06 mock treatment 4913240.0 -459509.20634921 -0.508084083805566 -0.4501 -0.8216 5047400.0 -78000.0 -0.09 5310440.0 -185000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J07 compound treatment 3894640.0 -1478109.20634921 -1.63436064282415 -2.5658 -0.9732 3187987 PK04_103185 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 4214520.0 -911000.0 -1.0 3690040.0 -1810000.0 -1.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J08 compound treatment 4664640.0 -708109.20634921 -0.78296367596345 -2.0202 -0.7314 3070607 PK04_103186 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3ccc(CN4CCCC4)cc3 5063240.0 -62200.0 -0.07 2857120.0 -2640000.0 -2.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J09 compound treatment 5317520.0 -55229.2063492099 -0.0610675048933002 -0.3911 -0.8887 3187988 PK04_103187 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 4841080.0 -284000.0 -0.31 5191920.0 -304000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J10 compound treatment 4835440.0 -537309.20634921 -0.594108348768894 -0.4001 -0.6661 3070608 PK04_103188 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4cccs4 5114800.0 -10600.0 -0.01 5408880.0 -86900.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J11 compound treatment 5770520.0 397770.79365079 0.43981928210397 0.3354 0.7248 3187989 PK04_103189 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 5122920.0 -2480.0 0.0 5639040.0 143000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J12 compound treatment 5538360.0 165610.79365079 0.183117568043736 1.1712 0.8674 3070609 PK04_103190 CN1CCC(=CC1C2CC2)c3ccc(CO)cc3 6158080.0 1030000.0 1.13 6207840.0 712000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J13 compound treatment 4606520.0 -766229.20634921 -0.847227561306234 -0.4198 -0.4581 3187990 PK04_103191 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 4961160.0 -164000.0 -0.18 5794640.0 299000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J14 compound treatment 5228200.0 -144549.20634921 -0.159829553049142 -0.2721 -0.7487 3187991 PK04_103192 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 4827600.0 -298000.0 -0.33 5510360.0 14600.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J15 compound treatment 2811400.0 -2561349.20634921 -2.83211031864517 -2.4252 -0.8041 3070610 PK04_103193 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 4259880.0 -866000.0 -0.95 5076680.0 -419000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J16 compound treatment 5242840.0 -129909.20634921 -0.143641953575323 -0.0106 -0.0377 3187992 PK04_103194 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 5327240.0 202000.0 0.22 5400440.0 -95400.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J17 compound treatment 3940080.0 -1432669.20634921 -1.5841171646759 -1.6978 -0.9142 3070654 PK04_103195 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 4415800.0 -710000.0 -0.78 4918440.0 -577000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J18 compound treatment 5372960.0 210.793650790118 2.3307672067039E-4 -0.1438 -0.6368 3187993 PK04_103196 CN1C(C2CC2)C3C4C(C1C=C3CCCO)C(=O)N(C(=O)N)C4=O 4920400.0 -205000.0 -0.22 5471040.0 -24800.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J19 compound treatment 5201120.0 -171629.20634921 -0.189772189234321 -0.4066 -0.3649 3070655 PK04_103197 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 5559360.0 434000.0 0.48 4509520.0 -986000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J20 compound treatment 5042640.0 -330109.20634921 -0.365005164959105 -0.7182 -0.9964 3187994 PK04_103198 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C3CC3 4728240.0 -397000.0 -0.43 5053320.0 -442000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J21 mock treatment 5362480.0 -10269.2063492099 -0.0113547677114077 -0.1734 -0.4799 5185760.0 60400.0 0.07 5141920.0 -354000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J22 mock treatment 5672480.0 299730.79365079 0.331415439726018 -0.3357 -0.459 4768160.0 -357000.0 -0.39 4976000.0 -520000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J23 compound treatment 2328080.0 -3044669.20634921 -3.36652224335052 -3.9483 -0.9166 3187995 PK04_103199 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 2834520.0 -2290000.0 -2.51 4535960.0 -960000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 J24 compound treatment 5770680.0 397930.79365079 0.439996195759422 -1.1098 -0.6421 3070656 PK04_103200 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)CCCO)C(=O)OCCS(=O)(=O)C 4085920.0 -1040000.0 -1.14 4276240.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K01 compound treatment 4525400.0 -847349.20634921 -0.936922784620183 -1.6736 -0.9899 3187996 PK04_103201 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 4382600.0 -743000.0 -0.81 4351440.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K02 compound treatment 3753880.0 -1618869.20634921 -1.79000043120767 -2.9228 -0.9841 3187997 PK04_103202 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2cccc(OCCO)c2)/C(=C)C(C)C 3300280.0 -1830000.0 -2.0 4226640.0 -1270000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K03 compound treatment 3941040.0 -1431709.20634921 -1.5830556827432 -1.6731 -0.9109 3070657 PK04_103203 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 4559280.0 -566000.0 -0.62 4803440.0 -692000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K04 compound treatment 3307400.0 -2065349.20634921 -2.28367798674529 -3.4109 -0.9937 3187998 PK04_103204 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 3459960.0 -1670000.0 -1.82 3701960.0 -1790000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K05 compound treatment 5079960.0 -292789.20634921 -0.323740054825025 -0.6178 -0.8966 3070658 PK04_103205 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 4979960.0 -145000.0 -0.16 4910920.0 -585000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K06 compound treatment 4565480.0 -807269.20634921 -0.892605913929563 -1.5272 -0.9991 3187999 PK04_103206 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 4283440.0 -842000.0 -0.92 4668160.0 -828000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K07 mock treatment 5290280.0 -82469.2063492099 -0.0911870547339307 0.1257 0.4615 5179440.0 54000.0 0.06 5744600.0 249000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K08 mock treatment 5366080.0 -6669.20634920988 -0.00737421046374731 0.1757 0.6679 5175120.0 49700.0 0.05 5752200.0 256000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K09 compound treatment 5025800.0 -346949.20634921 -0.383625327195383 -0.3708 -0.8724 3188000 PK04_103207 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 5002360.0 -123000.0 -0.13 5372280.0 -124000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K10 compound treatment 4860880.0 -511869.20634921 -0.565979077552094 -0.9751 -0.8887 3070659 PK04_103208 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccc(OCCO)cc2)/C(=C)C(C)C 4937560.0 -188000.0 -0.21 4581840.0 -914000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K11 compound treatment 4697600.0 -675149.20634921 -0.746519462940425 -1.6708 -0.9841 3188108 PK04_103209 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 4235640.0 -890000.0 -0.97 4327040.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K12 compound treatment 3994280.0 -1378469.20634921 -1.52418766389168 -2.1801 -0.989 3188109 PK04_103210 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 4076240.0 -1050000.0 -1.15 4396800.0 -1100000.0 -1.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K13 compound treatment 5175920.0 -196829.20634921 -0.217636089967944 -0.4709 -0.9838 3070660 PK04_103211 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 4887480.0 -238000.0 -0.26 5159600.0 -336000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K14 compound treatment 5751000.0 378250.79365079 0.418235816138878 0.2695 0.6365 3188110 PK04_103212 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 5111400.0 -14000.0 -0.02 5559400.0 63600.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K15 mock treatment 5853880.0 481130.79365079 0.53199129659424 0.4797 0.6832 5524440.0 399000.0 0.44 5358200.0 -138000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K16 mock treatment 5451920.0 79170.7936507901 0.0875399656860224 0.1734 0.9802 5202200.0 76800.0 0.08 5624000.0 128000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K17 compound treatment 5052680.0 -320069.20634921 -0.353903833079519 -0.209 -0.5799 3070661 PK04_103213 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 5165360.0 40000.0 0.04 5444200.0 -51600.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K18 compound treatment 5244720.0 -128029.20634921 -0.141563218123767 -0.1878 -0.9521 3188111 PK04_103214 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 5070360.0 -55000.0 -0.06 5372880.0 -123000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K19 compound treatment 5098760.0 -273989.20634921 -0.302952700309465 -0.1006 -0.1619 3188112 PK04_103215 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 4839040.0 -286000.0 -0.31 5936560.0 441000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K20 compound treatment 5128280.0 -244469.20634921 -0.27031213087865 -0.4883 -0.9685 3070662 PK04_103216 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 4782120.0 -343000.0 -0.38 5296920.0 -199000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K21 compound treatment 4966440.0 -406309.20634921 -0.449260293367917 -1.2999 -0.9561 3188113 PK04_103217 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 4399960.0 -725000.0 -0.79 4491520.0 -1000000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K22 compound treatment 5303840.0 -68909.2063492099 -0.0761936224344098 -0.395 -0.815 3188114 PK04_103218 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 4983680.0 -142000.0 -0.16 5044680.0 -451000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K23 mock treatment 5292080.0 -80669.2063492099 -0.0891967761101005 -0.8225 -0.8562 4614120.0 -511000.0 -0.56 4723040.0 -773000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 K24 mock treatment 4455280.0 -917469.20634921 -1.01445519412183 -1.5379 -0.9939 4418200.0 -707000.0 -0.77 4624200.0 -872000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L01 compound treatment 3523760.0 -1848989.20634921 -2.0444464961609 -4.4939 -0.9885 3070663 PK04_103219 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 2595640.0 -2530000.0 -2.77 2537560.0 -2960000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L02 compound treatment 3163440.0 -2209309.20634921 -2.44285604823785 -4.2448 -0.9992 3188115 PK04_103220 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4cccs4 2993400.0 -2130000.0 -2.33 2930360.0 -2570000.0 -2.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L03 compound treatment 3752760.0 -1619989.20634921 -1.79123882679584 -3.7812 -0.9907 3070664 PK04_103221 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 3082960.0 -2040000.0 -2.24 2983520.0 -2510000.0 -2.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L04 compound treatment 5659320.0 286570.79365079 0.316864291565126 -0.4055 -0.438 3188116 PK04_103222 CC1C=C(CCCO)C=C(C(=O)OCCS(=O)(=O)C)C(=CN1Cc2cccc(OC(F)(F)F)c2)C(=O)OCCS(=O)(=O)C 4345640.0 -780000.0 -0.85 5331160.0 -165000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L05 compound treatment 3789760.0 -1582989.20634921 -1.75032754397266 -2.7812 -0.9675 3070665 PK04_103223 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 4180760.0 -945000.0 -1.03 3470720.0 -2030000.0 -2.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L06 compound treatment 4610040.0 -762709.20634921 -0.8433354608863 -1.7327 -0.9939 3188117 PK04_103224 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 4149720.0 -976000.0 -1.07 4410440.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L07 mock treatment 4925440.0 -447309.20634921 -0.494594417577383 -0.4507 -0.7272 4792040.0 -333000.0 -0.37 5574560.0 78800.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L08 mock treatment 5583520.0 210770.79365079 0.233051447294942 -0.032 -0.1017 5029680.0 -95700.0 -0.1 5312760.0 -183000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L09 compound treatment 4212480.0 -1160269.20634921 -1.2829216662696 -2.3315 -0.976 3188118 PK04_103225 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 4199200.0 -926000.0 -1.01 3761000.0 -1730000.0 -1.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L10 compound treatment 5083040.0 -289709.20634921 -0.320334466957583 -0.908 -0.9557 3188119 PK04_103226 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 4472240.0 -653000.0 -0.72 4960640.0 -535000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L11 compound treatment 1602200.0 -3770549.20634921 -4.16913526972045 -6.8034 -0.9982 3070666 PK04_103227 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1828000.0 -3300000.0 -3.61 1506400.0 -3990000.0 -4.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L12 compound treatment 4109400.0 -1263349.20634921 -1.39689828879428 -3.5352 -0.9759 3188120 PK04_103228 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3cccs3 2935160.0 -2190000.0 -2.4 3176440.0 -2320000.0 -2.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L13 compound treatment 5420320.0 47570.7936507901 0.0525995187343364 0.4884 0.8131 3188121 PK04_103229 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 5353200.0 228000.0 0.25 6037760.0 542000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L14 compound treatment 4130760.0 -1241989.20634921 -1.37328031579149 -2.0694 -0.9944 3188122 PK04_103230 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CO)cc3)c4cccs4 4128920.0 -996000.0 -1.09 4380040.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L15 mock treatment 5450080.0 77330.7936507901 0.0855054586483293 -0.783 -0.5631 3859120.0 -1270000.0 -1.39 5441080.0 -54700.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L16 mock treatment 5246160.0 -126589.20634921 -0.139970995224702 -0.3354 -0.5806 4623400.0 -502000.0 -0.55 5604240.0 108000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L17 compound treatment 5051760.0 -320989.20634921 -0.354921086598365 -0.168 -0.4658 3070709 PK04_103231 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 5125160.0 -237.0 0.0 5559760.0 64000.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L18 compound treatment 5053240.0 -319509.20634921 -0.353284635285438 -0.9168 -0.9413 3188123 PK04_103232 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 4722120.0 -403000.0 -0.44 4705680.0 -790000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L19 compound treatment 5239480.0 -133269.20634921 -0.147357140339806 -0.3449 -0.7923 3070710 PK04_103233 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 4753320.0 -372000.0 -0.41 5453320.0 -42500.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L20 compound treatment 2970600.0 -2402149.20634921 -2.65608123147086 -3.3851 -0.9688 3188124 PK04_103234 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 3733880.0 -1390000.0 -1.52 3818520.0 -1680000.0 -1.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L21 compound treatment 5085480.0 -287269.20634921 -0.317636533711946 -1.6874 -0.6901 3070711 PK04_103235 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 2918320.0 -2210000.0 -2.42 5308440.0 -187000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L22 compound treatment 5014880.0 -357869.20634921 -0.395699684179953 -0.7575 -0.9935 3188125 PK04_103236 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 4752200.0 -373000.0 -0.41 4989960.0 -506000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L23 mock treatment 4964680.0 -408069.20634921 -0.451206343577885 -1.0739 -0.9694 4368000.0 -757000.0 -0.83 4918520.0 -577000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 L24 mock treatment 4739520.0 -633229.20634921 -0.700168085212113 -1.4415 -0.9599 4555960.0 -569000.0 -0.62 4327040.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M01 compound treatment 4408280.0 -964469.20634921 -1.06642358041073 -2.1704 -0.993 3070712 PK04_103237 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 3819680.0 -1310000.0 -1.43 4237320.0 -1260000.0 -1.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M02 compound treatment 3451200.0 -1921549.20634921 -2.12467683890819 -3.224 -0.995 3188126 PK04_103238 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccc(OCCO)cc3)/C(=C)C(C)C 3547240.0 -1580000.0 -1.73 3770800.0 -1720000.0 -1.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M03 compound treatment 4321920.0 -1050829.20634921 -1.16191272594072 -2.2617 -0.9844 3070713 PK04_103239 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 3632600.0 -1490000.0 -1.63 4379120.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M04 compound treatment 4334080.0 -1038669.20634921 -1.1484672881264 -2.1853 -0.9523 3188127 PK04_103240 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 3478600.0 -1650000.0 -1.8 4665680.0 -830000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M05 compound treatment 4740320.0 -632429.20634921 -0.699283516934855 -0.6614 -0.7848 3188128 PK04_103241 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 4696440.0 -429000.0 -0.47 5519160.0 23400.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M06 compound treatment 5108200.0 -264549.20634921 -0.292514794637822 -0.0361 -0.0939 3070714 PK04_103242 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 5352920.0 228000.0 0.25 5476640.0 -19200.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M07 compound treatment 5324520.0 -48229.2063492099 -0.0533275324672938 -0.2577 -0.8953 3188237 PK04_103243 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 4912000.0 -213000.0 -0.23 5337080.0 -159000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M08 compound treatment 4785800.0 -586949.20634921 -0.648995810372745 -1.2874 -0.9862 3070715 PK04_103244 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccc(CO)o2)/C(=C)C(C)C 4285920.0 -839000.0 -0.92 4836680.0 -659000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M09 mock treatment 5019320.0 -353429.20634921 -0.390790330241172 -1.1385 -0.9601 4441000.0 -684000.0 -0.75 4667040.0 -829000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M10 mock treatment 5238640.0 -134109.20634921 -0.148285937030926 -0.5559 -0.8278 4552080.0 -573000.0 -0.63 5309680.0 -186000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M11 compound treatment 5160440.0 -212309.20634921 -0.234752486132883 -0.5671 -0.8491 3188238 PK04_103245 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 4568400.0 -557000.0 -0.61 5358800.0 -137000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M12 compound treatment 3826360.0 -1546389.20634921 -1.70985854528811 -2.3884 -0.9827 3188239 PK04_103246 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 4143560.0 -982000.0 -1.08 4148880.0 -1350000.0 -1.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M13 mock treatment 5368800.0 -3949.20634920988 -0.00436667832107055 -0.1022 -0.3801 4891920.0 -233000.0 -0.26 5578560.0 82800.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M14 mock treatment 5623520.0 250770.79365079 0.277279861157836 0.1992 0.699 5185720.0 60300.0 0.07 5497560.0 1760.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M15 compound treatment 4838120.0 -534629.20634921 -0.59114504504008 -0.5172 -0.8119 3070716 PK04_103247 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 5050760.0 -74600.0 -0.08 5273600.0 -222000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M16 compound treatment 4764600.0 -608149.20634921 -0.672436869720079 -0.2507 -0.3605 3188240 PK04_103248 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 5269920.0 145000.0 0.16 5575480.0 79700.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M17 compound treatment 5672200.0 299450.79365079 0.331105840828978 -0.051 -0.0744 3070717 PK04_103249 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 4596960.0 -528000.0 -0.58 5654440.0 159000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M18 compound treatment 4481560.0 -891189.20634921 -0.985397126213914 -1.5114 -0.9942 3188241 PK04_103250 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 4323560.0 -802000.0 -0.88 4744200.0 -752000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M19 compound treatment 5536600.0 163850.79365079 0.181171517833768 -0.5169 -0.6554 3188242 PK04_103251 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 4570000.0 -555000.0 -0.61 5029280.0 -467000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M20 compound treatment 4890240.0 -482509.20634921 -0.53351542177673 -0.9194 -0.9997 3070718 PK04_103252 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccccc2OCCO)/C(=C)C(C)C 4627520.0 -498000.0 -0.55 4983880.0 -512000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M21 compound treatment 4016720.0 -1356029.20634921 -1.4993755237146 -1.0641 -0.6993 3188243 PK04_103253 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 4910400.0 -215000.0 -0.24 5387880.0 -108000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M22 compound treatment 4084400.0 -1288349.20634921 -1.42454104745858 -2.2505 -0.994 3188244 PK04_103254 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 4120840.0 -1000000.0 -1.1 4127280.0 -1370000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M23 compound treatment 5220080.0 -152669.20634921 -0.168807921063309 -1.2974 -0.8063 3188245 PK04_103255 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 3767520.0 -1360000.0 -1.49 4906560.0 -589000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 M24 compound treatment 3941880.0 -1430869.20634921 -1.58212688605207 -2.6874 -0.9725 3070768 PK04_103256 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 4137200.0 -988000.0 -1.08 3512440.0 -1980000.0 -1.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N01 compound treatment 4743840.0 -628909.20634921 -0.69539141651492 -2.6402 -0.849 3188246 PK04_103257 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 2520680.0 -2600000.0 -2.85 4474320.0 -1020000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N02 compound treatment 4416640.0 -956109.20634921 -1.05717984191339 -1.1605 -0.9131 3188247 PK04_103258 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)CCCO)C(=O)OCCS(=O)(=O)C 4825520.0 -300000.0 -0.33 4873560.0 -622000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N03 compound treatment 5079040.0 -293709.20634921 -0.324757308343872 -0.8912 -0.5784 3070772 PK04_103259 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 3771320.0 -1350000.0 -1.48 5758880.0 263000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N04 compound treatment 4595800.0 -776949.20634921 -0.85908077622149 -1.4302 -0.9881 3188248 PK04_103260 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 4245360.0 -880000.0 -0.96 4843760.0 -652000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N05 compound treatment 4620840.0 -751909.20634921 -0.831393789143318 -0.9855 -0.8854 3188249 PK04_103261 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 4463760.0 -662000.0 -0.72 5345320.0 -150000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N06 compound treatment 2907040.0 -2465709.20634921 -2.726360181099 -2.7838 -0.8968 3188250 PK04_103262 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 4221800.0 -904000.0 -0.99 4393920.0 -1100000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N07 compound treatment 5419880.0 47130.7936507901 0.0521130061818446 -0.0965 -0.5412 3070060 PK04_103263 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 5071160.0 -54200.0 -0.06 5336440.0 -159000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N08 compound treatment 4687360.0 -685389.20634921 -0.757841936889326 -1.2088 -0.9911 3188251 PK04_103264 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CN4CCCC4)cc3 4421760.0 -704000.0 -0.77 4932560.0 -563000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N09 mock treatment 4496080.0 -876669.20634921 -0.969342211981683 -1.1493 -0.9299 4825440.0 -300000.0 -0.33 4805480.0 -690000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N10 mock treatment 4709760.0 -662989.20634921 -0.733074025126106 -0.4628 -0.6283 5059600.0 -65800.0 -0.07 5499320.0 3520.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N11 compound treatment 5346040.0 -26709.2063492099 -0.029532645809057 -0.1438 -0.7351 3070061 PK04_103265 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 4950720.0 -175000.0 -0.19 5467680.0 -28100.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N12 compound treatment 4994280.0 -378469.20634921 -0.418477317319344 -0.1439 -0.324 3188252 PK04_103266 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 5145600.0 20200.0 0.02 5642400.0 147000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N13 mock treatment 4782760.0 -589989.20634921 -0.652357169826325 0.6827 0.4701 5971560.0 846000.0 0.93 6400720.0 905000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N14 mock treatment 5084640.0 -288109.20634921 -0.318565330403067 -0.1195 -0.2666 5373520.0 248000.0 0.27 5336160.0 -160000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N15 compound treatment 4478080.0 -894669.20634921 -0.989244998219986 -0.9914 -0.85 3070062 PK04_103267 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 5013720.0 -112000.0 -0.12 4892400.0 -603000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N16 compound treatment 5160320.0 -212429.20634921 -0.234885171374472 -0.8832 -0.9152 3188253 PK04_103268 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)c3ccc(CO)cc3 4659600.0 -466000.0 -0.51 4713800.0 -782000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N17 compound treatment 4681440.0 -691309.20634921 -0.764387742141034 -1.0309 -0.9545 3070063 PK04_103269 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 4500040.0 -625000.0 -0.68 5160720.0 -335000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N18 compound treatment 5023680.0 -349069.20634921 -0.385969433130117 -0.5717 -0.9217 3188254 PK04_103270 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2ccc(CN3CCCC3)cc2)CCCO)C(=O)OCCS(=O)(=O)C 4998480.0 -127000.0 -0.14 5032120.0 -464000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N19 compound treatment 5388200.0 15450.7936507901 0.0170841024024329 0.0135 0.0847 3070064 PK04_103271 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 5026120.0 -99300.0 -0.11 5610360.0 115000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N20 compound treatment 4227240.0 -1145509.20634921 -1.26660138155419 -1.786 -0.9732 3188255 PK04_103272 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)CCCO 4092000.0 -1030000.0 -1.13 4803080.0 -693000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N21 compound treatment 4937640.0 -435109.20634921 -0.481104751349201 -1.0286 -0.9771 3070065 PK04_103273 CCCCC(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 4417600.0 -708000.0 -0.78 4972280.0 -524000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N22 compound treatment 4479400.0 -893349.20634921 -0.98778546056251 -1.4458 -0.974 3188256 PK04_103274 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2sc3ccccc3c2Cl)c4ccc(CN5CCCC5)cc4)CCCO 4613240.0 -512000.0 -0.56 4543720.0 -952000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N23 compound treatment 4497440.0 -875309.20634921 -0.967838445910345 -0.4793 -0.3302 3070066 PK04_103275 CC(C)C(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 4492360.0 -633000.0 -0.69 6323680.0 828000.0 0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 N24 compound treatment 5076760.0 -295989.20634921 -0.327278327934057 -1.3613 -0.924 3188257 PK04_103276 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)CCCO 4226440.0 -899000.0 -0.98 4453480.0 -1040000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O01 compound treatment 4219920.0 -1152829.20634921 -1.2746951812911 -2.5869 -0.9928 3188258 PK04_103277 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 3764360.0 -1360000.0 -1.49 3786480.0 -1710000.0 -1.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O02 compound treatment 4040640.0 -1332109.20634921 -1.47292693222459 -2.5893 -0.9957 3070067 PK04_103278 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 3595480.0 -1530000.0 -1.68 4164200.0 -1330000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O03 compound treatment 4850920.0 -521829.20634921 -0.576991952603954 -1.591 -0.9604 3188259 PK04_103279 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 4256400.0 -869000.0 -0.95 4273080.0 -1220000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O04 compound treatment 4608640.0 -764109.20634921 -0.844883455371501 -1.8135 -0.9906 3188369 PK04_103280 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 4054800.0 -1070000.0 -1.17 4376040.0 -1120000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O05 compound treatment 4615840.0 -756909.20634921 -0.83692234087618 -1.8511 -0.9879 3070068 PK04_103281 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 4085160.0 -1040000.0 -1.14 4270080.0 -1230000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O06 compound treatment 4568480.0 -804269.20634921 -0.889288782889846 -1.4988 -0.9865 3188370 PK04_103282 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 4505960.0 -619000.0 -0.68 4471160.0 -1020000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O07 compound treatment 4987680.0 -385069.20634921 -0.425775005606721 -1.226 -0.8718 3070069 PK04_103283 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 3965480.0 -1160000.0 -1.27 5069840.0 -426000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O08 compound treatment 4643040.0 -729709.20634921 -0.806847019449412 -1.2825 -0.9207 3188371 PK04_103284 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccc(CO)o3)/C(=C)C(C)C 4826600.0 -299000.0 -0.33 4412320.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O09 compound treatment 4885280.0 -487469.20634921 -0.538999745095729 -1.0777 -0.9848 3188372 PK04_103285 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 4622640.0 -503000.0 -0.55 4721440.0 -774000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O10 compound treatment 5423640.0 50890.7936507901 0.0562704770849566 -0.3668 -0.5897 3070070 PK04_103286 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 4564200.0 -561000.0 -0.61 5419120.0 -76700.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O11 mock treatment 5460520.0 87770.7936507901 0.0970490746665445 -0.6064 -0.629 4932000.0 -193000.0 -0.21 4563560.0 -932000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O12 mock treatment 4791760.0 -580989.20634921 -0.642405776707174 -0.6888 -0.9078 4805080.0 -320000.0 -0.35 5296680.0 -199000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O13 compound treatment 5295400.0 -77349.2063492099 -0.0855258177594803 -0.6885 -0.7486 3188373 PK04_103287 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 4926840.0 -199000.0 -0.22 4609440.0 -886000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O14 compound treatment 3087680.0 -2285069.20634921 -2.52662466409417 -4.1724 -0.9955 3188374 PK04_103288 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccccc3OCCO)/C(=C)C(C)C 3218440.0 -1910000.0 -2.09 2893240.0 -2600000.0 -2.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O15 compound treatment 4204080.0 -1168669.20634921 -1.29220963318081 -1.5955 -0.9612 3070071 PK04_103289 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 4490880.0 -635000.0 -0.69 4722240.0 -774000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O16 compound treatment 3231520.0 -2141229.20634921 -2.3675792878432 -3.9343 -0.9995 3188375 PK04_103290 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 3067600.0 -2060000.0 -2.25 3310320.0 -2190000.0 -2.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O17 compound treatment 3451960.0 -1920789.20634921 -2.1238364990448 -3.6362 -0.9977 3070072 PK04_103291 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccc(OCCO)cc2)/C(=C)C(C)C 3377040.0 -1750000.0 -1.91 3244240.0 -2250000.0 -2.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O18 compound treatment 4713000.0 -659749.20634921 -0.729491523603211 -1.335 -0.9446 3188376 PK04_103292 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 4700520.0 -425000.0 -0.47 4382360.0 -1110000.0 -1.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O19 compound treatment 4957280.0 -415469.20634921 -0.45938860014252 -1.2101 -0.9501 3188377 PK04_103293 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 4204760.0 -921000.0 -1.01 4869680.0 -626000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O20 compound treatment 3496200.0 -1876549.20634921 -2.07491987331244 -3.6721 -0.9768 3070073 PK04_103294 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3cccc(OCCO)c3)/C(=C)C(C)C 3687600.0 -1440000.0 -1.57 2794600.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O21 compound treatment 4353160.0 -1019589.20634921 -1.1273703347138 -1.8821 -0.983 3188378 PK04_103295 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 4376200.0 -749000.0 -0.82 4188400.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O22 compound treatment 3597800.0 -1774949.20634921 -1.96257970210069 -3.8821 -0.9888 3188379 PK04_103296 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 3259280.0 -1870000.0 -2.04 2787720.0 -2710000.0 -2.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O23 compound treatment 4617240.0 -755509.20634921 -0.835374346390979 -1.7798 -0.9914 3070074 PK04_103297 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2cccc(OCCO)c2)/C(=C)C(C)C 4105160.0 -1020000.0 -1.12 4369760.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 O24 compound treatment 3989480.0 -1383269.20634921 -1.52949507355523 -2.284 -0.9934 3188380 PK04_103298 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 4054520.0 -1070000.0 -1.17 4246560.0 -1250000.0 -1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P01 compound treatment 3718320.0 -1654429.20634921 -1.82931949113179 -3.0762 -0.9992 3070075 PK04_103299 COCC(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 3459720.0 -1670000.0 -1.82 3827080.0 -1670000.0 -1.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P02 compound treatment 4118080.0 -1254669.20634921 -1.38730072298603 -2.1872 -0.992 3188381 PK04_103300 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)c3ccc(CO)cc3 3878760.0 -1250000.0 -1.37 4463680.0 -1030000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P03 compound treatment 4073680.0 -1299069.20634921 -1.43639426237384 -3.2016 -0.986 3188382 PK04_103301 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 3377040.0 -1750000.0 -1.91 3309320.0 -2190000.0 -2.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P04 compound treatment 4101600.0 -1271149.20634921 -1.40552282949754 -2.4909 -0.9817 3070118 PK04_103302 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)CCCO 4108400.0 -1020000.0 -1.11 3707160.0 -1790000.0 -1.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P05 compound treatment 4648480.0 -724269.20634921 -0.800831955164059 -2.1891 -0.968 3188383 PK04_103303 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 3742200.0 -1380000.0 -1.51 4024960.0 -1470000.0 -1.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P06 compound treatment 4044640.0 -1328109.20634921 -1.4685040908383 -2.269 -0.9899 3070119 PK04_103304 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cccc(OC(F)(F)F)c3)CCCO 4169400.0 -956000.0 -1.05 4086200.0 -1410000.0 -1.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P07 compound treatment 4041960.0 -1330789.20634921 -1.47146739456711 -2.3744 -0.9944 3188384 PK04_103305 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 4061320.0 -1060000.0 -1.17 4025280.0 -1470000.0 -1.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P08 compound treatment 3786520.0 -1586229.20634921 -1.75391004549555 -2.6524 -0.9932 3188385 PK04_103306 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3ccc(CN4CCCC4)cc3)CCCO 3731400.0 -1390000.0 -1.53 4186960.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P09 compound treatment 3581640.0 -1791109.20634921 -1.98044798130129 -2.6563 -0.978 3070120 PK04_103307 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 4024720.0 -1100000.0 -1.21 4085760.0 -1410000.0 -1.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P10 compound treatment 3914880.0 -1457869.20634921 -1.61198106540953 -2.5298 -0.995 3188386 PK04_103308 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 3972720.0 -1150000.0 -1.26 3993680.0 -1500000.0 -1.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P11 mock treatment 5033920.0 -338829.20634921 -0.374646959181216 -1.4707 -0.9198 3980720.0 -1140000.0 -1.25 4579920.0 -916000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P12 mock treatment 4301560.0 -1071189.20634921 -1.18442498859694 -1.9618 -0.9664 4449280.0 -676000.0 -0.74 4028040.0 -1470000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P13 compound treatment 2679680.0 -2693069.20634921 -2.97775448549568 -5.0939 -0.9946 3070121 PK04_103309 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 2114320.0 -3010000.0 -3.3 2957200.0 -2540000.0 -2.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P14 compound treatment 4298160.0 -1074589.20634921 -1.18818440377528 -1.8865 -0.9841 3188387 PK04_103310 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)CCCO 4381600.0 -744000.0 -0.81 4235560.0 -1260000.0 -1.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P15 compound treatment 4659280.0 -713469.20634921 -0.788890283421078 -1.8477 -0.975 3188388 PK04_103311 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 4184320.0 -941000.0 -1.03 4119960.0 -1380000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P16 compound treatment 4332040.0 -1040709.20634921 -1.15072293723341 -2.4325 -0.9907 3070122 PK04_103312 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2ccc(CN3CCCC3)cc2)CCCO 3649360.0 -1480000.0 -1.62 4054920.0 -1440000.0 -1.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P17 compound treatment 3306880.0 -2065869.20634921 -2.28425295612551 -3.9623 -1.0 3188389 PK04_103313 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 3034440.0 -2090000.0 -2.29 3215120.0 -2280000.0 -2.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P18 compound treatment 4306720.0 -1066029.20634921 -1.17871952320862 -2.0911 -0.9982 3188390 PK04_103314 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)c5ccc(CO)cc5 4087360.0 -1040000.0 -1.14 4194040.0 -1300000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P19 compound treatment 4070280.0 -1302469.20634921 -1.44015367755219 -2.6648 -0.9928 3070123 PK04_103315 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 3482840.0 -1640000.0 -1.8 4124120.0 -1370000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P20 compound treatment 4056360.0 -1316389.20634921 -1.45554516557647 -2.4087 -0.9934 3188503 PK04_103316 COP(=O)(OC)/N=C\1/CC(=CC(C)N1Cc2cccc(OC(F)(F)F)c2)CCCO 4056560.0 -1070000.0 -1.17 3955320.0 -1540000.0 -1.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P21 compound treatment 4147240.0 -1225509.20634921 -1.35505820927998 -2.7462 -0.9881 3188504 PK04_103317 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 3779800.0 -1350000.0 -1.47 3574680.0 -1920000.0 -1.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P22 compound treatment 4201360.0 -1171389.20634921 -1.29521716532348 -2.6214 -0.9947 3070124 PK04_103318 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cc3OCOc3cc2Br)c4ccc(CN5CCCC5)cc4)CCCO 3676880.0 -1450000.0 -1.59 3842760.0 -1650000.0 -1.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P23 compound treatment 3823760.0 -1548989.20634921 -1.7127333921892 -3.3286 -0.9956 3188505 PK04_103319 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 3390400.0 -1730000.0 -1.9 3350920.0 -2140000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2103 P24 compound treatment 3260040.0 -2112709.20634921 -2.33604442875896 -3.5091 -0.9781 3188506 PK04_103320 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)c5ccc(CO)cc5 3831760.0 -1290000.0 -1.42 3178800.0 -2320000.0 -2.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A01 mock treatment 3876160.0 -974730.39548023 -1.07776948340104 -2.1183 -0.9816 3803360.0 -943000.0 -1.03 3366600.0 -1550000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A02 mock treatment 4273680.0 -577210.39548023 -0.638227506431603 -1.3483 -0.9086 4356080.0 -390000.0 -0.43 3654360.0 -1270000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A03 mock treatment 4596080.0 -254810.39548023 -0.281746490696681 -1.0536 -0.8271 4425320.0 -321000.0 -0.35 3732280.0 -1190000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A04 mock treatment 4206280.0 -644610.39548023 -0.712752383790579 -1.2971 -0.9277 4382120.0 -364000.0 -0.4 3788720.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A05 mock treatment 4644640.0 -206250.39548023 -0.228053196267128 -0.8734 -0.7132 4669280.0 -77200.0 -0.08 3723600.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A06 mock treatment 4478800.0 -372090.39548023 -0.411424200142685 -1.0428 -0.8113 4570920.0 -176000.0 -0.19 3721280.0 -1200000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A07 mock treatment 4460080.0 -390810.39548023 -0.432123097830519 -0.6405 -0.771 4775320.0 28800.0 0.03 4213160.0 -706000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A08 mock treatment 4703760.0 -147130.39548023 -0.162683600577771 -0.6789 -0.6622 4745600.0 -901.0 0.0 3910880.0 -1010000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A09 mock treatment 4892160.0 41269.6045197695 0.0456322287164578 -0.5076 -0.5795 4699360.0 -47100.0 -0.05 4049320.0 -870000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A10 mock treatment 5232360.0 381469.60451977 0.421794888620368 -0.3079 -0.3196 4660480.0 -86000.0 -0.09 4061640.0 -858000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A11 mock treatment 4547160.0 -303730.39548023 -0.335837840851 -0.7228 -0.8203 4647240.0 -99300.0 -0.11 4114880.0 -805000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A12 mock treatment 3174080.0 -1676810.39548023 -1.85406660352255 -3.3047 -0.9955 3178360.0 -1570000.0 -1.72 2774520.0 -2140000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A13 mock treatment 4935880.0 84989.6045197695 0.0939738850686005 -0.3596 -0.3992 4896240.0 150000.0 0.16 4041720.0 -878000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A14 mock treatment 4713440.0 -137450.39548023 -0.151980324422951 -0.4312 -0.6704 4773320.0 26800.0 0.03 4297440.0 -622000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A15 mock treatment 4657320.0 -193570.39548023 -0.214032789072591 -0.507 -0.5123 4988520.0 242000.0 0.27 3993640.0 -926000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A16 mock treatment 4927600.0 76709.6045197695 0.0848186033989816 -0.5154 -0.5615 4686320.0 -60200.0 -0.07 4011120.0 -908000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A17 mock treatment 4831640.0 -19250.3954802305 -0.0212853614581002 -0.5766 -0.65 4659000.0 -87500.0 -0.1 4041000.0 -878000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A18 mock treatment 4615240.0 -235650.39548023 -0.260561080456355 -0.5966 -0.5142 5032800.0 286000.0 0.31 3836960.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A19 mock treatment 4389240.0 -461650.39548023 -0.510451618781704 -0.9686 -0.8171 4653240.0 -93300.0 -0.1 3858200.0 -1060000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A20 mock treatment 4379600.0 -471290.39548023 -0.521110666522661 -1.0418 -0.8031 4655600.0 -90900.0 -0.1 3739880.0 -1180000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A21 mock treatment 4344320.0 -506570.39548023 -0.560120127549733 -1.075 -0.8368 4603640.0 -143000.0 -0.16 3778080.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A22 mock treatment 4299680.0 -551210.39548023 -0.609479037420723 -1.1316 -0.8428 4595280.0 -151000.0 -0.17 3738840.0 -1180000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A23 mock treatment 5039000.0 188109.60451977 0.20799473600714 -0.9453 -0.661 4257400.0 -489000.0 -0.54 3614480.0 -1300000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 A24 mock treatment 3591880.0 -1259010.39548023 -1.39210082072463 -2.2947 -0.9735 3911160.0 -835000.0 -0.91 3257720.0 -1660000.0 -1.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B01 mock treatment 4603240.0 -247650.39548023 -0.273829604615223 -1.209 -0.8948 4113320.0 -633000.0 -0.69 3796640.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B02 mock treatment 4935040.0 84149.6045197695 0.0930450883774798 -0.5633 -0.6609 4505920.0 -241000.0 -0.26 4117160.0 -802000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B03 compound treatment 3593200.0 -1257690.39548023 -1.39064128306715 -3.1463 -0.9856 2277 HSCI1_000001 CCc1nc([nH]c1c2ccncc2)c3ccc(OC)cc3 2805800.0 -1940000.0 -2.13 2992800.0 -1930000.0 -1.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B04 compound treatment 4509200.0 -341690.39548023 -0.377810605606886 -1.4916 -0.9291 656 HSCI1_000002 Oc1c(Br)cc(/C=C/2\C(=O)Nc3ccc(I)cc23)cc1Br 3711400.0 -1040000.0 -1.13 3851040.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B05 compound treatment 3727640.0 -1123250.39548023 -1.24198958407396 -2.6776 -0.9901 2114187 HSCI1_000003 CCOC(=O)c1cccc(NC(=O)CBr)c1 3246520.0 -1500000.0 -1.64 3172600.0 -1750000.0 -1.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B06 compound treatment 5217680.0 366789.60451977 0.405563060732686 0.1364 0.1612 1362420 HSCI1_000004 Oc1c(I)cc(Cl)cc1C(=O)Nc2cc(ccc2Cl)S(=O)(=O)c3ccc(Cl)cc3 5142160.0 396000.0 0.43 4318960.0 -600000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B07 compound treatment 5273400.0 422509.60451977 0.467173241243697 0.2089 0.2593 3175973 HSCI1_000005 COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O 5119400.0 373000.0 0.41 4407560.0 -512000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B08 compound treatment 5701240.0 850349.60451977 0.940240355921207 0.7954 0.5463 3175974 HSCI1_000006 CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1CCC(O)C(O)C1O)OC 5635760.0 889000.0 0.97 4385000.0 -534000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B09 compound treatment 5050960.0 200069.60451977 0.221219031752146 0.406 0.8414 9 HSCI1_000007 [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc34)c2c1 5134600.0 388000.0 0.43 4976160.0 56700.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B10 compound treatment 3981240.0 -869650.39548023 -0.961581440183219 -2.7394 -0.8946 571 HSCI1_000008 CCCCCCCCCCCCCCCCCCOC[C@H](COC(=O)OC1C(O)C(O)C(O)C(CO)C1O)OC 3754160.0 -992000.0 -1.09 2232520.0 -2690000.0 -2.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B11 mock treatment 5204520.0 353629.60451977 0.391011912571794 0.268 0.3572 5192200.0 446000.0 0.49 4506080.0 -413000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B12 mock treatment 5309440.0 458549.60451977 0.507023042134164 -0.2231 -0.1529 5121880.0 375000.0 0.41 3619560.0 -1300000.0 -1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B13 mock treatment 5292280.0 441389.60451977 0.488049052586983 0.1205 0.0719 5647040.0 901000.0 0.99 3658440.0 -1260000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B14 mock treatment 5268960.0 418069.60451977 0.462263887304916 1.0294 0.8899 5673920.0 927000.0 1.02 5223480.0 304000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B15 compound treatment 4412360.0 -438530.39548023 -0.484887595568951 -0.7583 -0.8549 3055039 HSCI1_000009 Cn1cnc2nc(NCCO)nc(NCc3ccccc3)c12 4663000.0 -83500.0 -0.09 4185040.0 -734000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B16 compound treatment 3999200.0 -851690.39548023 -0.941722882358779 -1.7099 -0.9662 3175975 HSCI1_000010 CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1C(O)C(O)C(O)CC1OC)OC 4116840.0 -630000.0 -0.69 3593880.0 -1330000.0 -1.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B17 compound treatment 5147320.0 296429.60451977 0.327765280747856 0.2584 0.3725 3055043 HSCI1_000011 CCCCCCCCCCCCCCC[C@@H](O)[C@H](N)CO 5192200.0 446000.0 0.49 4552480.0 -367000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B18 compound treatment 5263600.0 412709.60451977 0.456337279847288 0.3381 0.3618 2326 HSCI1_000012 CCCCCC(=O)O[C@@H]1[C@@H](OC(=O)/C(=C\C)/C)C(=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(=O)C)[C@@H]12)OC(=O)CCC)C 5328800.0 582000.0 0.64 4412840.0 -507000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B19 compound treatment 5189920.0 339029.60451977 0.374868541511838 0.1308 0.1836 2026 HSCI1_000013 CCCCCCCCCCNc1cc(CO)c2cc[nH]c2c1 5063960.0 317000.0 0.35 4425240.0 -494000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B20 compound treatment 252640.0 -4598250.39548023 -5.08433303841285 -8.452 -0.9993 193 HSCI1_000014 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 257920.0 -4490000.0 -4.92 296520.0 -4620000.0 -4.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B21 compound treatment 3725240.0 -1125650.39548023 -1.24464328890574 -2.5242 -0.9828 3055048 HSCI1_000015 Nc1nc(Cl)nc2n(cnc12)C3OC(CO)[C@H](O)[C@H]3F 3062840.0 -1680000.0 -1.84 3640360.0 -1280000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B22 compound treatment 1854480.0 -2996410.39548023 -3.31316197685941 -5.8966 -0.9997 3175977 HSCI1_000016 CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@]41OC(=O)CCCCCCCCC)CO 1549760.0 -3200000.0 -3.5 1532360.0 -3390000.0 -3.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B23 mock treatment 4613120.0 -237770.39548023 -0.262905186391088 -0.5415 -0.7775 4718400.0 -28100.0 -0.03 4277520.0 -642000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 B24 mock treatment 4133880.0 -717010.39548023 -0.792805812882416 -1.4438 -0.9499 4271840.0 -475000.0 -0.52 3735480.0 -1180000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C01 mock treatment 4590160.0 -260730.39548023 -0.288292295948389 -0.6148 -0.8324 4650920.0 -95600.0 -0.1 4249920.0 -670000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C02 mock treatment 4510640.0 -340250.39548023 -0.376218382707822 -0.4173 -0.6941 4846440.0 99900.0 0.11 4465000.0 -454000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C03 compound treatment 5127720.0 276829.60451977 0.306093357955038 0.4597 0.9935 2257 HSCI1_000017 COc1ccc(cc1)C(=O)CBr 4959200.0 213000.0 0.23 5175720.0 256000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C04 compound treatment 1613240.0 -3237650.39548023 -3.57990354086652 -5.7543 -0.9946 561 HSCI1_000018 C[C@@H](NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N)c2ccccc2 2161280.0 -2590000.0 -2.83 1376480.0 -3540000.0 -3.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C05 compound treatment 351120.0 -4499770.39548023 -4.9754426834824 -8.3561 -0.9985 2256 HSCI1_000019 Oc1ccc(cc1)C(=O)CBr 139000.0 -4610000.0 -5.05 483280.0 -4440000.0 -4.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C06 compound treatment 5579000.0 728109.60451977 0.805078323156204 0.4209 0.3552 1000099 HSCI1_000020 C[C@H](NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N)c2ccccc2 5272040.0 526000.0 0.58 4270200.0 -649000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C07 compound treatment 4573400.0 -277490.39548023 -0.306824001356941 -0.7813 -0.7704 2258 HSCI1_000021 OC(=O)COc1ccc(cc1)C(=O)CBr 4670360.0 -76100.0 -0.08 3959920.0 -960000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C08 compound treatment 5822640.0 971749.60451977 1.07447359199509 1.1019 0.8443 2227 HSCI1_000022 CCCCCCCCCCCCCCCC(=O)C(F)(F)F 5416760.0 670000.0 0.73 5019080.0 99600.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C09 compound treatment 4738160.0 -112730.39548023 -0.124647164655683 0.1674 0.273 2147 HSCI1_000023 CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(F)OC 5274080.0 528000.0 0.58 4756880.0 -163000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C10 compound treatment 2455560.0 -2395330.39548023 -2.64854160174171 -4.4972 -0.9993 617 HSCI1_000024 COc1cc(OC)c(/C=C\2/C(=O)Nc3ccccc23)c(OC)c1 2496520.0 -2250000.0 -2.46 2252200.0 -2670000.0 -2.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C11 mock treatment 5529080.0 678189.60451977 0.749881262655313 0.7879 0.8896 5144600.0 398000.0 0.44 5097680.0 178000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C12 mock treatment 5233120.0 382229.60451977 0.422635228483763 0.8165 0.9282 5407040.0 661000.0 0.72 5186720.0 267000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C13 mock treatment 5463240.0 612349.60451977 0.67708129343699 1.1005 0.9365 5571720.0 825000.0 0.9 5243560.0 324000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C14 mock treatment 5585320.0 734429.60451977 0.812066412546541 0.8846 0.8333 5370040.0 624000.0 0.68 4956640.0 37200.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C15 mock treatment 5905400.0 1054509.60451977 1.16598218027742 0.8288 0.5741 5405120.0 659000.0 0.72 4469280.0 -450000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C16 mock treatment 5426120.0 575229.60451977 0.636037325372225 0.6452 0.6516 5404160.0 658000.0 0.72 4681480.0 -238000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C17 compound treatment 4937960.0 87069.6045197695 0.096273762589471 -1.1821 -0.7731 3055108 HSCI1_000025 CSCC1OC([C@@H](O)[C@H]1O)n2ccc3c(N)ncnc23 3881560.0 -865000.0 -0.95 3727280.0 -1190000.0 -1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C18 compound treatment 5269000.0 418109.60451977 0.462308115718779 -0.0899 -0.1399 3055110 HSCI1_000026 ClCC(=O)c1cc(Br)c(Br)s1 4523520.0 -223000.0 -0.24 4546960.0 -372000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C19 compound treatment 3768120.0 -1082770.39548023 -1.19723042924472 -5.2564 -0.9125 2121 HSCI1_000027 Oc1ccc(cc1)c2oc3cc(O)cc(O)c3c(=O)c2O 684040.0 -4060000.0 -4.45 1473480.0 -3450000.0 -3.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C20 compound treatment 110320.0 -4740570.39548023 -5.24169773493702 -8.7454 -0.9993 1916983 HSCI1_000028 CC(C)C(N1C(=O)/C(=C/c2ccccc2)/SC1=S)C(=O)O 84760.0 -4660000.0 -5.11 135920.0 -4780000.0 -4.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C21 compound treatment 4992240.0 141349.60451977 0.156291720201418 -0.2757 -0.3115 2188 HSCI1_000029 Oc1ccc(O)c2C(=O)C(=C(Cl)C(=O)c12)Cl 4939440.0 193000.0 0.21 4077360.0 -842000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C22 compound treatment 4949200.0 98309.6045197695 0.108701946884944 0.1736 0.245 563 HSCI1_000030 Oc1ccc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc1O 5277600.0 531000.0 0.58 4531160.0 -388000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C23 compound treatment 5315160.0 464269.60451977 0.513347705316558 0.0526 0.0592 1031143 HSCI1_000031 CS(=O)(=O)SCCN 4980000.0 233000.0 0.26 4243920.0 -676000.0 -0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 C24 mock treatment 4432400.0 -418490.39548023 -0.462729160223641 -0.6104 -0.8978 4647600.0 -98900.0 -0.11 4435000.0 -484000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D01 mock treatment 4825480.0 -25410.3954802305 -0.0280965371929858 -0.4612 -0.8209 4480960.0 -266000.0 -0.29 4441240.0 -478000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D02 mock treatment 5064080.0 213189.60451977 0.235725951499175 0.2078 0.6923 4908920.0 162000.0 0.18 4865960.0 -53500.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D03 compound treatment 5100040.0 249149.60451977 0.275487295561916 -0.4287 -0.5561 551 HSCI1_000032 CC(C)(C)c1cc(C=C(C#N)C#N)cc(Br)c1O 4275680.0 -471000.0 -0.52 4418880.0 -501000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D04 compound treatment 5084120.0 233229.60451977 0.257884386844484 -0.3635 -0.4558 3479696 HSCI1_000033 OC(=O)C(CCCCNC(=O)CNC(=O)c1cccc(c1)C(=O)NCC(=O)NCCCCC(NC(=O)OCc2ccc(cc2)C(F)(F)F)C(=O)O)NC(=O)OCc3ccc(cc3)C(F)(F)F 4070680.0 -676000.0 -0.74 4772640.0 -147000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D05 compound treatment 5028280.0 177389.60451977 0.196141521091885 -0.1709 -0.2828 674 HSCI1_000034 CCOC(=O)c1c(C)[nH]c(/C=C/2\C(=O)Nc3ccccc23)c1C 4814640.0 68100.0 0.07 4354720.0 -565000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D06 compound treatment 4747080.0 -103810.39548023 -0.114784228364257 0.1168 0.314 146 HSCI1_000035 CCCCCC#CCC#CCC#CCC#CCCCC(=O)O 5068040.0 322000.0 0.35 4884560.0 -34900.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D07 compound treatment 5414640.0 563749.60451977 0.623343770593574 0.875 0.8856 3175981 HSCI1_000036 O=c1sn(Cc2ccccc2)c(=S)n1Cc3ccccc3 5435000.0 688000.0 0.75 5057160.0 138000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D08 compound treatment 5318920.0 468029.60451977 0.51750517621967 1.1547 0.8695 1000097 HSCI1_000037 Cc1c(C)c2OC(C)(COc3ccc(CC4SC(=O)NC4=O)cc3)CCc2c(C)c1O 5830240.0 1080000.0 1.19 5214120.0 295000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D09 compound treatment 5158680.0 307789.60451977 0.340326150284918 0.5764 0.7439 628 HSCI1_000038 Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc34)c2c1 5381240.0 635000.0 0.7 4882440.0 -37000.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D10 compound treatment 4895000.0 44109.6045197695 0.0487724461007233 -0.019 -0.0567 3175982 HSCI1_000039 COc1ccc(Nc2nccc(NCCO)n2)cc1 4920600.0 174000.0 0.19 4648000.0 -271000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D11 mock treatment 5585240.0 734349.60451977 0.811977955718816 0.8676 0.8018 5399280.0 653000.0 0.71 4895400.0 -24000.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D12 mock treatment 6006920.0 1156029.60451977 1.27823389466144 1.4097 0.8489 5709320.0 963000.0 1.05 5028080.0 109000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D13 mock treatment 5370760.0 519869.60451977 0.57482520058598 0.7579 0.8834 5319200.0 573000.0 0.63 5029800.0 110000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D14 mock treatment 6144560.0 1293669.60451977 1.43042386676366 1.4882 0.8271 5741920.0 995000.0 1.09 4976440.0 57000.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D15 mock treatment 5876680.0 1025789.60451977 1.13422617912386 0.9633 0.7045 5418800.0 672000.0 0.74 4718120.0 -201000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D16 mock treatment 5094960.0 244069.60451977 0.269870287001328 0.2297 0.4863 5048400.0 302000.0 0.33 4717600.0 -202000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D17 compound treatment 5789360.0 938469.60451977 1.03767555166116 1.2914 0.9444 584 HSCI1_000040 Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N 5469720.0 723000.0 0.79 5325160.0 406000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D18 compound treatment 5466800.0 615909.60451977 0.681017622270788 0.5449 0.7174 2180 HSCI1_000041 COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c4ncn(C(C)C)c4n2)cc1 5047480.0 301000.0 0.33 4852800.0 -66600.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D19 compound treatment 4367880.0 -483010.39548023 -0.534069591784489 -1.3364 -0.935 3055161 HSCI1_000042 COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC 4201680.0 -545000.0 -0.6 3739600.0 -1180000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D20 compound treatment 5545880.0 694989.60451977 0.768457196477728 1.0391 0.9301 2067 HSCI1_000043 CC(C)C(C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1)c3ccc(Cl)cc3 5446360.0 700000.0 0.77 5183400.0 264000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D21 compound treatment 5254880.0 403989.60451977 0.446695485625177 0.1686 0.2634 3055164 HSCI1_000044 N/C(=C(/C#N)\c1ccccc1C(F)(F)F)/Sc2ccc(N)cc2 4963120.0 217000.0 0.24 4528880.0 -391000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D22 compound treatment 5115480.0 264589.60451977 0.292559463312993 -0.2044 -0.3021 2407 HSCI1_000045 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ncc(C)s3 4712120.0 -34400.0 -0.04 4312720.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D23 compound treatment 1677680.0 -3173210.39548023 -3.5086515661334 -6.1492 -0.9998 550 HSCI1_000046 COC1=C(Br)[C@H](O)[C@](O)(CC#N)C=C1Br 1552680.0 -3190000.0 -3.5 1287920.0 -3630000.0 -3.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 D24 mock treatment 3514840.0 -1336050.39548023 -1.47728474582456 -1.2557 -0.7825 4677800.0 -68700.0 -0.08 4299200.0 -620000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E01 mock treatment 4592040.0 -258850.39548023 -0.286213560496833 -0.5158 -0.9284 4602200.0 -144000.0 -0.16 4471840.0 -448000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E02 mock treatment 5086400.0 235509.60451977 0.260405406434669 0.0173 0.0561 4651680.0 -94800.0 -0.1 4793240.0 -126000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E03 mock treatment 4841920.0 -8970.39548023045 -0.00991865909533657 -0.0926 -0.1666 5029800.0 283000.0 0.31 4460440.0 -459000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E04 mock treatment 5794320.0 943429.60451977 1.04315987498016 1.0093 0.8728 5053280.0 307000.0 0.34 5287240.0 368000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E05 compound treatment 4064440.0 -786450.39548023 -0.8695863393484 -3.0631 -0.9171 2294 HSCI1_000047 CC(=O)NC(C(=O)O)C(C)(C)SN=O 2237600.0 -2510000.0 -2.75 3237200.0 -1680000.0 -1.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E06 compound treatment 5412200.0 561309.60451977 0.620645837347938 0.9145 0.9754 3175983 HSCI1_000048 CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCC/C=C/C/C=C/C\C=C\C\C=C\CCCCC 5297840.0 551000.0 0.6 5277680.0 358000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E07 compound treatment 5564080.0 713189.60451977 0.788581124785345 1.4822 0.9397 640 HSCI1_000049 O=C/1Nc2ccccc2\C1=C\c3ccc[nH]3 5902800.0 1160000.0 1.27 5430040.0 511000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E08 compound treatment 4060840.0 -790050.39548023 -0.87356689659606 0.0312 0.0278 1907779 HSCI1_000050 CC(C)n1cnc2c(NCc3ccccc3)nc(NCCO)nc12 5330400.0 584000.0 0.64 5206560.0 287000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E09 mock treatment 5322440.0 471549.60451977 0.521397276639604 0.9883 0.9047 5587920.0 841000.0 0.92 5187400.0 268000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E10 mock treatment 5684920.0 834029.60451977 0.922195163065146 1.3195 0.9191 5711440.0 965000.0 1.06 5224840.0 305000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E11 compound treatment 5581080.0 730189.60451977 0.807378200677075 0.4423 0.4756 627 HSCI1_000051 C=CC(=O)c1ccc2ccccc2c1 4430120.0 -316000.0 -0.35 5223560.0 304000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E12 compound treatment 2265200.0 -2585690.39548023 -2.85902462331522 -4.7635 -0.9984 536 HSCI1_000052 ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23 2436600.0 -2310000.0 -2.53 2067600.0 -2850000.0 -2.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E13 compound treatment 5702080.0 851189.60451977 0.941169152612328 0.7609 0.6801 593 HSCI1_000053 Oc1ccc2ccc(=O)oc2c1O 5269160.0 523000.0 0.57 4724440.0 -195000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E14 compound treatment 3604480.0 -1246410.39548023 -1.37816887035781 -3.3785 -0.9787 3055208 HSCI1_000054 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)C(C)C 2640560.0 -2110000.0 -2.31 2759840.0 -2160000.0 -2.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E15 mock treatment 5682680.0 831789.60451977 0.919718371888824 0.7831 0.8066 4921320.0 175000.0 0.19 5163800.0 244000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E16 mock treatment 5372840.0 521949.60451977 0.57712507810685 0.8378 0.8109 5528840.0 782000.0 0.86 4936560.0 17100.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E17 mock treatment 5394480.0 543589.60451977 0.601052650006676 0.9087 0.9902 5247440.0 501000.0 0.55 5342240.0 423000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E18 mock treatment 5529960.0 679069.60451977 0.750854287760297 0.9347 0.9488 5254280.0 508000.0 0.56 5230280.0 311000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E19 compound treatment 5496720.0 645829.60451977 0.714100475840232 1.0097 0.9176 1912 HSCI1_000055 [O-][N+](=O)c1cccc2cn[nH]c12 5481600.0 735000.0 0.81 5148280.0 229000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E20 compound treatment 5448560.0 597669.60451977 0.660849465549308 0.997 0.9941 3175984 HSCI1_000056 CCCC(=O)OCSC(=S)OC1CC2CC1C3CCCC23 5251880.0 505000.0 0.55 5430160.0 511000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E21 compound treatment 5658400.0 807509.60451977 0.892871724674048 0.2837 0.2422 596 HSCI1_000057 CN(C)c1ccc(/C=C\2/C(=O)Nc3ccccc23)cc1 4109000.0 -638000.0 -0.7 5215080.0 296000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E22 compound treatment 1934440.0 -2916450.39548023 -3.22474937754748 -5.5611 -0.9999 564 HSCI1_000058 Oc1ccc(/C=C(\C#N)/C(=O)NCCCCc2ccccc2)cc1O 1862720.0 -2880000.0 -3.16 1681760.0 -3240000.0 -3.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E23 compound treatment 4966560.0 115669.60451977 0.12789707850144 -0.147 -0.4694 2175 HSCI1_000059 CCCCCCCCN1C(=O)C(=C(C)C1(C)O)C(=O)C 4512320.0 -234000.0 -0.26 4793920.0 -126000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 E24 mock treatment 4787240.0 -63650.3954802305 -0.0703789008459121 -0.3641 -0.6141 4771880.0 25400.0 0.03 4333480.0 -586000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F01 mock treatment 4911680.0 60789.6045197695 0.0672156946815499 -0.729 -0.6457 4540480.0 -206000.0 -0.23 3819080.0 -1100000.0 -1.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F02 mock treatment 5394400.0 543509.60451977 0.60096419317895 0.2996 0.4326 4928200.0 182000.0 0.2 4639480.0 -280000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F03 mock treatment 5599720.0 748829.60451977 0.827988641537183 0.6175 0.7248 4925000.0 178000.0 0.2 4965360.0 45900.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F04 mock treatment 5572800.0 721909.60451977 0.798222919007456 0.6989 0.7926 5086680.0 340000.0 0.37 4959040.0 39600.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F05 compound treatment 5266000.0 415109.60451977 0.458990984679062 0.5517 0.7115 2108 HSCI1_000060 COc1cc2C/C(=C\c3cc(C)c(O)c(C)c3)/C(=O)c2c(N)c1OC 5306920.0 560000.0 0.61 4802640.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F06 compound treatment 5520120.0 669229.60451977 0.739974097950025 0.95 0.8606 2303 HSCI1_000061 COc1cc2CCN3Cc4c(OC)c(O)ccc4CC3c2cc1O 5489840.0 743000.0 0.81 5010560.0 91100.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F07 compound treatment 3073360.0 -1777530.39548023 -1.96543374962932 -3.2681 -0.9964 1967 HSCI1_000062 Brc1cccc(Nc2ncnc3cc4[nH]cnc4cc23)c1 3227840.0 -1520000.0 -1.66 2894720.0 -2020000.0 -2.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F08 compound treatment 5512680.0 661789.60451977 0.731747612971527 0.8962 0.8732 1918768 HSCI1_000063 Clc1ccc(C(=O)n2nnc3ccccc23)c(Cl)c1 5395960.0 649000.0 0.71 5028280.0 109000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F09 mock treatment 5516840.0 665949.60451977 0.736347368013268 0.9545 0.7731 5649120.0 903000.0 0.99 4848080.0 -71400.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F10 mock treatment 5875680.0 1024789.60451977 1.13312046877729 0.7781 0.6162 4498280.0 -248000.0 -0.27 5404200.0 485000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F11 compound treatment 5897120.0 1046229.60451977 1.1568268986078 1.2388 0.8881 583 HSCI1_000064 CC(C)n1cnc2c(NCc3ccccc3)nc(NCCCO)nc12 5420440.0 674000.0 0.74 5169320.0 250000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F12 compound treatment 4570040.0 -280850.39548023 -0.310539188121425 -1.1559 -0.9319 1085933 HSCI1_000065 COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2 4043240.0 -703000.0 -0.77 4001360.0 -918000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F13 compound treatment 4865080.0 14189.6045197695 0.0156895925312788 -0.5045 -0.7697 675 HSCI1_000066 Brc1ccc2NC(=O)/C(=C\c3cc4CCCCc4[nH]3)/c2c1 4221840.0 -525000.0 -0.57 4605640.0 -314000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F14 compound treatment 5441320.0 590429.60451977 0.652844122640124 0.4893 0.7308 2144 HSCI1_000067 O=C(Nc1ccccc1)C2C(=O)NC(=S)NC2=O 4870800.0 124000.0 0.14 4977680.0 58200.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F15 mock treatment 5441120.0 590229.60451977 0.65262298057081 0.7424 0.9306 5100160.0 354000.0 0.39 5164480.0 245000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F16 mock treatment 5465520.0 614629.60451977 0.679602313027175 0.9861 0.8537 5594400.0 848000.0 0.93 5018840.0 99400.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F17 mock treatment 5624280.0 773389.60451977 0.855144887649 0.9677 0.906 4947480.0 201000.0 0.22 5518120.0 599000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F18 mock treatment 5519920.0 669029.60451977 0.73975295588071 0.6501 0.6584 5306440.0 560000.0 0.61 4693240.0 -226000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F19 compound treatment 5387040.0 536149.60451977 0.592826165028178 1.0828 0.8739 643 HSCI1_000068 CNc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N 5720120.0 974000.0 1.07 5135080.0 216000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F20 compound treatment 5237480.0 386589.60451977 0.427456125594818 0.7314 0.9972 122 HSCI1_000069 C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34 5165240.0 419000.0 0.46 5298960.0 380000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F21 compound treatment 5435240.0 584349.60451977 0.646121403732964 0.3218 0.4918 590 HSCI1_000070 CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12 4759440.0 12900.0 0.01 4816960.0 -102000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F22 compound treatment 5666680.0 815789.60451977 0.902027006343667 0.4726 0.4714 2060831 HSCI1_000071 O=C1CCCC(=O)C1CC2C(=O)CCCC2=O 4988400.0 242000.0 0.26 4572320.0 -347000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F23 compound treatment 5166640.0 315749.60451977 0.349127604643634 0.233 0.5733 3176054 HSCI1_000072 N/C(=C(/C#N)\C(=C(/N)\Sc1ccccc1)\[N+]#[C-])/Sc2ccccc2 4903240.0 157000.0 0.17 4802600.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 F24 mock treatment 4295840.0 -555050.39548023 -0.61372496515156 -0.5951 -0.8074 4738320.0 -8180.0 -0.01 4512800.0 -407000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G01 mock treatment 4655080.0 -195810.39548023 -0.216509580248913 -0.3753 -0.6868 4805000.0 58500.0 0.06 4423560.0 -496000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G02 compound treatment 2239000.0 -2611890.39548023 -2.88799423439541 -5.0567 -0.9998 305 HSCI1_000073 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)C 2123520.0 -2620000.0 -2.87 1932080.0 -2990000.0 -3.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G03 mock treatment 5157840.0 306949.60451977 0.339397353593797 0.526 0.9903 5045960.0 299000.0 0.33 5162240.0 243000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G04 mock treatment 5502080.0 651189.60451977 0.72002708329786 1.0176 0.9728 5338840.0 592000.0 0.65 5311880.0 392000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G05 mock treatment 5308480.0 457589.60451977 0.505961560201455 1.4125 0.9646 5679080.0 933000.0 1.02 5835440.0 916000.0 0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G06 mock treatment 5663840.0 812949.60451977 0.898886788959402 1.0421 0.944 5170280.0 424000.0 0.46 5359800.0 440000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G07 compound treatment 5171560.0 320669.60451977 0.35456769954877 0.9271 0.9161 2073 HSCI1_000074 CC(=CCC/C(=C/CC/C(=C/CSc1nc[nH]n1)/C)/C)C 5537400.0 791000.0 0.87 5303240.0 384000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G08 compound treatment 1903560.0 -2947330.39548023 -3.25889371304964 -5.5643 -0.9996 3176055 HSCI1_000075 CCOc1cc(/C=C(/C#N)\C(=O)N)cc(CSc2ccccc2)c1O 1926960.0 -2820000.0 -3.09 1640240.0 -3280000.0 -3.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G09 compound treatment 3784120.0 -1066770.39548023 -1.17953906369956 -1.755 -0.9322 2335 HSCI1_000076 COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC 4317240.0 -429000.0 -0.47 3534320.0 -1390000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G10 compound treatment 2955040.0 -1895850.39548023 -2.09626139783575 -3.6182 -1.0 3055275 HSCI1_000077 CC(C)(C)OC(=O)NC(CC(=O)CCl)C(=O)Cc1ccccc1 2828240.0 -1920000.0 -2.1 2856960.0 -2060000.0 -2.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G11 compound treatment 5319760.0 468869.60451977 0.518433972910791 0.2996 0.3535 2134 HSCI1_000078 COc1cc(O)c(cc1/C=C/C(=O)c2ccc(O)cc2)C(C)(C)C=C 5179560.0 433000.0 0.47 4447360.0 -472000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G12 compound treatment 5042320.0 191429.60451977 0.21166569435776 -0.4696 -0.6107 3055277 HSCI1_000079 COc1cc(cc(CN(C)CCc2ccc(cc2)[N+](=O)[O-])c1O)N(C)C 4184720.0 -562000.0 -0.62 4511080.0 -408000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G13 compound treatment 1693560.0 -3157330.39548023 -3.49109288582983 -5.4319 -0.9957 1002387 HSCI1_000080 Oc1ccc(C=C(C#N)C#N)cc1 2213760.0 -2530000.0 -2.77 1787000.0 -3130000.0 -3.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G14 compound treatment 2955440.0 -1895450.39548023 -2.09581911369713 -3.8672 -0.9985 3176058 HSCI1_000081 C[C@@H]1[C@@H](O)[C@@]2(O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@]13O)C2(C)C 2560400.0 -2190000.0 -2.39 2719040.0 -2200000.0 -2.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G15 compound treatment 2169280.0 -2681610.39548023 -2.96508435975844 -7.0924 -0.9804 672 HSCI1_000082 Oc1ccc(CC(C#N)C#N)cc1 266520.0 -4480000.0 -4.91 522040.0 -4400000.0 -4.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G16 compound treatment 5373200.0 522309.60451977 0.577523133831616 0.7285 0.9591 3176059 HSCI1_000083 OCc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1CO 5121320.0 375000.0 0.41 5192360.0 273000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G17 mock treatment 5522560.0 671669.60451977 0.742672031195661 1.2359 0.9993 5365680.0 619000.0 0.68 5636840.0 717000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G18 mock treatment 5843120.0 992229.60451977 1.09711853989289 1.309 0.9292 5481040.0 735000.0 0.8 5283840.0 364000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G19 mock treatment 5196800.0 345909.60451977 0.382475828696256 0.9181 0.9173 5527240.0 781000.0 0.86 5270960.0 352000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G20 mock treatment 5607960.0 757069.60451977 0.837099694792939 0.9668 0.9388 5066720.0 320000.0 0.35 5404520.0 485000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G21 compound treatment 5339400.0 488509.60451977 0.540150124117471 -0.2279 -0.1866 3415700 HSCI1_000084 CCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC 3755600.0 -991000.0 -1.09 5069160.0 150000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G22 compound treatment 4437960.0 -412930.39548023 -0.456581410696699 -1.9053 -0.9235 3176060 HSCI1_000085 CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]4CCCC[C@@H]4N)nc12 3401800.0 -1340000.0 -1.47 3553440.0 -1370000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G23 compound treatment 4105760.0 -745130.39548023 -0.823898387828031 -1.6256 -0.9858 3055326 HSCI1_000086 Cc1ccc(cc1)c2cn3c4CCCCc4sc3n2 3990920.0 -756000.0 -0.83 3759360.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 G24 mock treatment 4656280.0 -194610.39548023 -0.215182727833026 -0.0291 -0.0736 5022400.0 276000.0 0.3 4782520.0 -137000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H01 mock treatment 5178960.0 328069.60451977 0.362749956113405 0.1611 0.3988 4816520.0 70000.0 0.08 4759640.0 -160000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H02 compound treatment 4297600.0 -553290.39548023 -0.611778914941593 -0.4962 -0.7585 1886 HSCI1_000087 NCCOB(c1ccccc1)c2ccccc2 4731320.0 -15200.0 -0.02 4689240.0 -230000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H03 mock treatment 5105240.0 254349.60451977 0.281236989364092 0.6215 0.8851 5311480.0 565000.0 0.62 5095400.0 176000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H04 mock treatment 5434240.0 583349.60451977 0.645015693386392 1.0617 0.9343 5031360.0 285000.0 0.31 5798200.0 879000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H05 mock treatment 4681480.0 -169410.39548023 -0.187318827099403 0.7773 0.6938 5582480.0 836000.0 0.92 5535360.0 616000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H06 mock treatment 5472800.0 621909.60451977 0.687651884350222 1.2019 0.9558 5621680.0 875000.0 0.96 5353600.0 434000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H07 compound treatment 5495160.0 644269.60451977 0.712375567699579 1.7345 0.978 2278 HSCI1_000088 Oc1cc(ccc1NC(=O)Nc2ccccc2Br)[N+](=O)[O-] 5863040.0 1120000.0 1.22 5984800.0 1070000.0 1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H08 compound treatment 5294640.0 443749.60451977 0.490658529004893 1.2987 0.9712 1891 HSCI1_000089 Clc1oc(=O)c2ccccc2c1Cl 5567960.0 821000.0 0.9 5775560.0 856000.0 0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H09 compound treatment 5093560.0 242669.60451977 0.268322292516127 0.9266 0.8864 1966 HSCI1_000090 Cn1cnc2cc3c(Nc4cccc(Br)c4)ncnc3cc12 5587320.0 841000.0 0.92 5333800.0 414000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H10 compound treatment 2439080.0 -2411810.39548023 -2.66676370825322 -4.5293 -0.9992 3176061 HSCI1_000091 CC1(CCC2(C)O1)C(C2C(=O)O)C(=O)O 2492400.0 -2250000.0 -2.47 2219320.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H11 compound treatment 2927000.0 -1923890.39548023 -2.12726551595364 -4.6295 -0.9875 291 HSCI1_000092 CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1 2261280.0 -2490000.0 -2.72 1761160.0 -3160000.0 -3.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H12 compound treatment 5697760.0 846869.60451977 0.936392483915135 1.1232 0.8908 3055333 HSCI1_000093 O=C/1Nc2ccccc2\C1=C/c3c[nH]cn3 5498760.0 752000.0 0.82 5104040.0 185000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H13 compound treatment 5791080.0 940189.60451977 1.03957737345727 1.4748 0.9539 3176062 HSCI1_000094 CC[C@@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1 5698320.0 952000.0 1.04 5390200.0 471000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H14 compound treatment 5683440.0 832549.60451977 0.920558711752219 1.2784 0.9362 1040138 HSCI1_000095 COc1cc(C=O)c(cc1OC)[N+](=O)[O-] 5611440.0 865000.0 0.95 5264760.0 345000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H15 compound treatment 5851960.0 1001069.60451977 1.10689301935659 1.6196 0.9861 3176063 HSCI1_000096 CC(C)n1cnc2c(NCc3ccccc3O)nc(NCCCO)nc12 5410160.0 664000.0 0.73 5887520.0 968000.0 0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H16 compound treatment 3064080.0 -1786810.39548023 -1.97569474164551 -5.5176 -0.965 2109 HSCI1_000097 OCc1c[nH]c2ccccc12 1137160.0 -3610000.0 -3.95 1303920.0 -3620000.0 -3.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H17 mock treatment 5575880.0 724989.60451977 0.801628506874898 1.2373 0.9512 5109280.0 363000.0 0.4 5860240.0 941000.0 0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H18 mock treatment 5517520.0 666629.60451977 0.737099251048937 0.9202 0.7943 4713320.0 -33200.0 -0.04 5809320.0 890000.0 0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H19 mock treatment 5040760.0 189869.60451977 0.209940786217108 0.5531 0.7898 5351520.0 605000.0 0.66 5004560.0 85100.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H20 mock treatment 5087200.0 236309.60451977 0.261289974711927 0.8345 0.949 5327920.0 581000.0 0.64 5464800.0 545000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H21 compound treatment 3734440.0 -1116450.39548023 -1.23447075371727 -3.5676 -0.962 3176064 HSCI1_000098 O/N=C\1/C(=C\2/C(=O)Nc3ccc(cc23)S(=O)(=O)O)/Nc4ccccc14 2455680.0 -2290000.0 -2.51 2492000.0 -2430000.0 -2.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H22 compound treatment 4612840.0 -238050.39548023 -0.263214785288128 -0.0824 -0.2595 2069332 HSCI1_000099 CC(=O)/C(=N/O)/C 4902160.0 156000.0 0.17 4869640.0 -49800.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H23 compound treatment 5033160.0 182269.60451977 0.201537387583158 -1.4752 -0.7415 642 HSCI1_000100 COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC 3266720.0 -1480000.0 -1.62 3787400.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 H24 mock treatment 3925400.0 -925490.39548023 -1.02332430593582 -1.2023 -0.9473 4297680.0 -449000.0 -0.49 4353800.0 -566000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I01 mock treatment 4467760.0 -383130.39548023 -0.423631242368843 -0.4655 -0.9197 4533640.0 -213000.0 -0.23 4770520.0 -149000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I02 compound treatment 3480640.0 -1370250.39548023 -1.51510003967733 -2.2808 -0.9934 666 HSCI1_000101 CC(C)c1cc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc(C(C)C)c1O 3701200.0 -1050000.0 -1.14 3633440.0 -1290000.0 -1.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I03 compound treatment 4720240.0 -130650.39548023 -0.144461494066259 -0.2439 -0.6385 3176066 HSCI1_000102 CCCCC/C=C/C/C=C/C\C=C\C\C=C\CCCC(=O)C(F)(F)F 4809400.0 62900.0 0.07 4573760.0 -346000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I04 compound treatment 4542840.0 -308050.39548023 -0.340614509548192 -0.4333 -0.5604 2104844 HSCI1_000103 Oc1ccc(O)c(CNc2ccc(cc2)C(=O)OC3(CC4CC5CC(C4)C3)C5)c1 4152080.0 -594000.0 -0.65 5159600.0 240000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I05 mock treatment 5149000.0 298109.60451977 0.329622874130098 0.7617 0.9621 5307240.0 561000.0 0.61 5293680.0 374000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I06 mock treatment 4745960.0 -104930.39548023 -0.116022623952418 0.5815 0.7244 5253200.0 507000.0 0.55 5485680.0 566000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I07 mock treatment 5718760.0 867869.60451977 0.959612401193155 1.2921 0.9757 5410880.0 664000.0 0.73 5468360.0 549000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I08 mock treatment 5404800.0 553909.60451977 0.612463580783302 0.8668 0.8735 4853280.0 107000.0 0.12 5688680.0 769000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I09 compound treatment 5195080.0 344189.60451977 0.380574006900151 0.6989 0.9932 626 HSCI1_000104 CC(C)N(CCC(=O)c1ccc2ccccc2c1)Cc3ccccc3 5075640.0 329000.0 0.36 5387200.0 468000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I10 compound treatment 5142320.0 291429.60451977 0.322236729014995 0.6651 0.9029 3055340 HSCI1_000105 Cc1ccc(N/N=C/2\C(=O)Nc3ccc(Br)cc23)cc1 4926840.0 180000.0 0.2 5549440.0 630000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I11 compound treatment 5518680.0 667789.60451977 0.738381875050961 1.2238 0.984 568 HSCI1_000106 COc1ccc(C=C(C#N)C#N)cc1 5518080.0 772000.0 0.84 5453920.0 534000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I12 compound treatment 5175960.0 325069.60451977 0.359432825073688 0.766 0.8358 3176067 HSCI1_000107 Ic1cccc(CSc2nnc(o2)c3ccncc3)c1 4869960.0 123000.0 0.14 5748600.0 829000.0 0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I13 compound treatment 4416160.0 -434730.39548023 -0.480685896251976 -0.8346 -0.9995 558 HSCI1_000108 Oc1ccc(C=C(C#N)C#N)cc1O 4322520.0 -424000.0 -0.46 4420600.0 -499000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I14 compound treatment 4448680.0 -402210.39548023 -0.444728195781444 -0.1725 -0.3665 3176068 HSCI1_000109 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)CCCCC 4739280.0 -7220.0 -0.01 5072760.0 153000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I15 compound treatment 5264720.0 413829.60451977 0.457575675435449 0.5412 0.9411 1975 HSCI1_000110 C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)CC[C@@H]1c5ccc(=O)oc5 4914680.0 168000.0 0.18 5213960.0 295000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I16 compound treatment 3333640.0 -1517250.39548023 -1.67763946062347 -3.1579 -0.9984 1001980 HSCI1_000111 CCCCCCCC/C=C/CCCCCCCC(=O)OCC(CO)OC(=O)C 3000640.0 -1750000.0 -1.91 3046080.0 -1870000.0 -1.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I17 compound treatment 1449520.0 -3401370.39548023 -3.76093043880734 -7.365 -0.996 130 HSCI1_000112 C/C(=C\C=C\C(=C\C(=O)Nc1ccc(O)cc1)\C)/C=C/C2=C(C)CCCC2(C)C 461320.0 -4290000.0 -4.69 631880.0 -4290000.0 -4.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I18 compound treatment 2353680.0 -2497210.39548023 -2.7611913718505 -4.7083 -0.9995 1922639 HSCI1_000113 CC(C)C(N1C(=O)/C(=C/c2ccc(Br)cc2)/SC1=S)C(=O)O 2198960.0 -2550000.0 -2.79 2324840.0 -2590000.0 -2.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I19 mock treatment 5270080.0 419189.60451977 0.463502282893077 0.7719 0.8957 5392400.0 646000.0 0.71 5085040.0 166000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I20 mock treatment 4756760.0 -94130.3954802305 -0.104080952209437 0.4068 0.6989 5095440.0 349000.0 0.38 5344440.0 425000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I21 mock treatment 4953440.0 102549.60451977 0.113390158754411 0.4638 0.8399 5211680.0 465000.0 0.51 5099360.0 180000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I22 mock treatment 4811720.0 -39170.3954802305 -0.0433111115618212 0.2412 0.4725 4704920.0 -41600.0 -0.05 5424200.0 505000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I23 compound treatment 4154640.0 -696250.39548023 -0.769851266087575 -0.5948 -0.7511 565 HSCI1_000114 Oc1cc(C=C(C#N)C#N)cc(O)c1O 4614640.0 -132000.0 -0.14 4803960.0 -115000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 I24 mock treatment 4989080.0 138189.60451977 0.152797675506249 -0.251 -0.5088 4337680.0 -409000.0 -0.45 4780160.0 -139000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J01 mock treatment 4541240.0 -309650.39548023 -0.342383646102708 -0.5338 -0.9114 4633920.0 -113000.0 -0.12 4462240.0 -457000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J02 compound treatment 3863360.0 -987530.39548023 -1.09192257583717 -1.7542 -0.9811 3176070 HSCI1_000115 OC(=O)c1c(Br)c(Br)c(Br)c(Br)c1c2c3ccc(O)cc3oc4cc(=O)ccc24 4072000.0 -675000.0 -0.74 3715920.0 -1200000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J03 compound treatment 2326080.0 -2524810.39548023 -2.79170897741589 -5.222 -0.9986 294 HSCI1_000116 [O-][N+](=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4ccc(F)cc4 1881440.0 -2870000.0 -3.14 1815160.0 -3100000.0 -3.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J04 compound treatment 4971320.0 120429.60451977 0.133160259751124 -0.1485 -0.4427 3055387 HSCI1_000117 C[C@@]12CCC3C(CCC4=C[C@H](O)CCC34)C2CC[C@@H]1O 4656240.0 -90300.0 -0.1 4629040.0 -290000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J05 mock treatment 5257120.0 406229.60451977 0.449172276801499 0.7947 0.9646 5310000.0 563000.0 0.62 5228560.0 309000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J06 mock treatment 5072200.0 221309.60451977 0.244704319513342 0.4141 0.751 5197240.0 451000.0 0.49 4898400.0 -21000.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J07 mock treatment 4902440.0 51549.6045197695 0.0569989310792215 0.708 0.7971 5074080.0 328000.0 0.36 5727080.0 808000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J08 mock treatment 5017200.0 166309.60451977 0.183890250451863 0.8772 0.8448 5103920.0 357000.0 0.39 5860200.0 941000.0 0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J09 compound treatment 3360640.0 -1490250.39548023 -1.64778528126601 -2.5666 -0.9966 633 HSCI1_000118 OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3ccccc3O 3505680.0 -1240000.0 -1.36 3485760.0 -1430000.0 -1.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J10 compound treatment 4970280.0 119389.60451977 0.132010320990689 0.0463 0.0424 2251 HSCI1_000119 O=C(NC1=CC(=O)c2ccccc2C1=O)c3ccccc3 4022520.0 -724000.0 -0.79 5657920.0 738000.0 0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J11 compound treatment 5316480.0 465589.60451977 0.514807242974033 1.1975 0.9774 645 HSCI1_000120 Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1 5366520.0 620000.0 0.68 5796640.0 877000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J12 compound treatment 5320760.0 469869.60451977 0.519539683257363 0.9779 0.9943 3176071 HSCI1_000121 Nc1nc(Cl)nc2n(cnc12)C3C[C@@H](O)C(CO)O3 5225080.0 479000.0 0.52 5567240.0 648000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J13 compound treatment 5239920.0 389029.60451977 0.430154058840455 0.7106 0.9883 646 HSCI1_000122 CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 5043040.0 297000.0 0.32 5393600.0 474000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J14 compound treatment 3600280.0 -1250610.39548023 -1.38281285381342 -2.6457 -0.9125 854065 HSCI1_000123 CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O 2528400.0 -2220000.0 -2.43 4151640.0 -768000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J15 compound treatment 2040240.0 -2810650.39548023 -3.10776522288013 -5.9626 -0.9836 670 HSCI1_000124 CN(C)S(=O)(=O)c1ccc2NC(=O)/C(=C\c3cc4CCCCc4[nH]3)/c2c1 795040.0 -3950000.0 -4.33 2037360.0 -2880000.0 -2.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J16 compound treatment 4903800.0 52909.6045197695 0.0585026971505599 0.0483 0.2739 3176072 HSCI1_000125 CN(C)c1ccc(/C=C/2\C(=O)Nc3ccccc23)c4ccccc14 4651160.0 -95300.0 -0.1 5048560.0 129000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J17 compound treatment 4764720.0 -86170.3954802305 -0.0952794978507212 0.3175 0.6671 1996 HSCI1_000126 CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 4978840.0 232000.0 0.25 5308880.0 389000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J18 compound treatment 4895400.0 44509.6045197695 0.0492147302393522 -0.4168 -0.7021 2268 HSCI1_000127 CC(=CC1C(C(=O)OCc2coc(Cc3ccccc3)c2)C1(C)C)C 4246160.0 -500000.0 -0.55 4697000.0 -222000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J19 mock treatment 5085720.0 234829.60451977 0.259653523399 0.7181 0.9666 5185240.0 439000.0 0.48 5421240.0 502000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J20 mock treatment 4905440.0 54549.6045197695 0.0603160621189385 0.6176 0.8185 5360520.0 614000.0 0.67 5255160.0 336000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J21 mock treatment 4835080.0 -15810.3954802305 -0.0174817178658914 0.1042 0.3457 4664920.0 -81600.0 -0.09 5205680.0 286000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J22 mock treatment 4637840.0 -213050.39548023 -0.23557202662382 -0.3947 -0.8947 4414920.0 -332000.0 -0.36 4834880.0 -84600.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J23 compound treatment 4926040.0 75149.6045197695 0.0830936952583287 -0.2516 -0.4198 654 HSCI1_000128 CC(C)C(CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1 4208280.0 -538000.0 -0.59 4989680.0 70200.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 J24 mock treatment 4336800.0 -514090.39548023 -0.568435069355957 -0.5815 -0.8642 4664160.0 -82300.0 -0.09 4572040.0 -347000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K01 mock treatment 4273520.0 -577370.39548023 -0.638404420087055 -0.6899 -0.9073 4411400.0 -335000.0 -0.37 4730640.0 -189000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K02 compound treatment 4461520.0 -389370.39548023 -0.430530874931455 -0.5887 -0.977 3055432 HSCI1_000129 CCOC(=O)c1cc(OC)c(OC)cc1NC(=O)c2cc(OC)c(OC)c(OC)c2 4519240.0 -227000.0 -0.25 4580360.0 -339000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K03 compound treatment 5099320.0 248429.60451977 0.274691184112384 0.0697 0.1298 570 HSCI1_000130 NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N 4386840.0 -360000.0 -0.39 5158480.0 239000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K04 compound treatment 3551080.0 -1299810.39548023 -1.43721380286478 -3.3698 -0.9787 1005921 HSCI1_000131 OCC1OC(Oc2cc(O)c3c(=O)c(coc3c2)c4ccc(O)cc4)C(O)C(O)C1O 2953880.0 -1790000.0 -1.96 2491880.0 -2430000.0 -2.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K05 compound treatment 4036560.0 -814330.39548023 -0.900413543810837 -1.9866 -0.9885 559 HSCI1_000132 OC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N 3611120.0 -1140000.0 -1.24 3626920.0 -1290000.0 -1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K06 compound treatment 3608440.0 -1242450.39548023 -1.37379025738539 -1.6249 -0.9421 620 HSCI1_000133 COc1cc(/C=C(\C#N)/C(=O)c2ccc(O)c(O)c2)cc(I)c1O 3944200.0 -802000.0 -0.88 4359440.0 -560000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K07 mock treatment 5212560.0 361669.60451977 0.399901823758236 1.0735 0.9064 5140560.0 394000.0 0.43 5943640.0 1020000.0 1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K08 mock treatment 5323800.0 472909.60451977 0.522901042710943 0.8298 0.9159 4931720.0 185000.0 0.2 5628400.0 709000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K09 mock treatment 4848160.0 -2730.39548023045 -0.00301902653272516 -0.4327 -0.401 3798000.0 -949000.0 -1.04 5210720.0 291000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K10 mock treatment 5138560.0 287669.60451977 0.318079258111883 0.6058 0.9781 5000920.0 254000.0 0.28 5370480.0 451000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K11 compound treatment 4785000.0 -65890.3954802305 -0.0728556920222342 0.2039 0.4233 553 HSCI1_000134 Oc1cc(C=C(C#N)C#N)ccc1[N+](=O)[O-] 4702880.0 -43600.0 -0.05 5391520.0 472000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K12 compound treatment 4419920.0 -430970.39548023 -0.476528425348864 -0.5361 -0.5889 3176129 HSCI1_000135 Oc1cc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc(I)c1O 4083880.0 -663000.0 -0.73 5192160.0 273000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K13 compound treatment 4645200.0 -205690.39548023 -0.227433998473047 -0.0878 -0.2048 1000035 HSCI1_000136 O=C1c2ccccc2-c3n[nH]c4cccc1c34 4548960.0 -198000.0 -0.22 5210160.0 291000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K14 compound treatment 4983040.0 132149.60451977 0.146119185012952 0.7075 0.7716 1 HSCI1_000137 Oc1ccc(/C=C(\C#N)/C(=O)NCCCNC(=O)\C(=C\c2ccc(O)c(O)c2)\C#N)cc1O 4925000.0 178000.0 0.2 5800080.0 881000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K15 mock treatment 4882640.0 31749.6045197695 0.0351058662170891 0.5378 0.7852 4989760.0 243000.0 0.27 5547240.0 628000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K16 mock treatment 5099400.0 248509.60451977 0.27477964094011 0.9178 0.8872 5113800.0 367000.0 0.4 5828800.0 909000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K17 compound treatment 4431520.0 -419370.39548023 -0.463702185328625 -0.8196 -0.8234 554 HSCI1_000138 Oc1cc(C=C(C#N)C#N)cc([N+](=O)[O-])c1O 3945400.0 -801000.0 -0.88 4841080.0 -78400.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K18 compound treatment 3930520.0 -920370.39548023 -1.01766306896137 -1.5472 -0.9627 3176130 HSCI1_000139 CN(C)c1ccc2c(c3ccccc3C(=O)O)c4ccc(=[N+](C)C)cc4oc2c1.CC(=O)NCCSS(=O)(=O)C 3724680.0 -1020000.0 -1.12 4378320.0 -541000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K19 compound treatment 5227200.0 376309.60451977 0.416089423232055 0.9281 0.967 555 HSCI1_000140 Cc1cc2ncc(nc2cc1C)c3ccccc3 5164280.0 418000.0 0.46 5650720.0 731000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K20 compound treatment 2345520.0 -2505370.39548023 -2.77021396827853 -5.0609 -0.9955 2311 HSCI1_000141 COC(=O)c1c(c2cc(OC)c(OC)c(OC)c2)c3ccnc(OCc4ncccn4)c3c(=O)n1Cc5ccnc(C)c5 1722960.0 -3020000.0 -3.31 2244560.0 -2670000.0 -2.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K21 mock treatment 4676400.0 -174490.39548023 -0.19293583565999 -0.2421 -0.7972 4753800.0 7300.0 0.01 4685920.0 -234000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K22 mock treatment 4448360.0 -402530.39548023 -0.445082023092347 -0.4499 -0.7546 4799640.0 53100.0 0.06 4528560.0 -391000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K23 mock treatment 4528400.0 -322490.39548023 -0.356580966952697 -0.1869 -0.4746 4654720.0 -91800.0 -0.1 5052360.0 133000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 K24 mock treatment 4655360.0 -195530.39548023 -0.216199981351872 -0.5657 -0.8628 4202400.0 -544000.0 -0.6 4752280.0 -167000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L01 mock treatment 4122880.0 -728010.39548023 -0.804968626694712 -0.66 -0.7231 4361160.0 -385000.0 -0.42 5003000.0 83600.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L02 compound treatment 3184720.0 -1666170.39548023 -1.84230184543502 -2.0797 -0.9328 1995 HSCI1_000142 CN(C1CCCCC1)C(=O)CCCOc2ccc3[nH]c(=O)ccc3c2 3834080.0 -912000.0 -1.0 4161560.0 -758000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L03 compound treatment 3258960.0 -1591930.39548023 -1.76021390930549 -2.6636 -0.9937 3176131 HSCI1_000143 Nc1ncnc2n(cc(I)c12)C3OC(CO)[C@H](O)[C@@H]3O 3363480.0 -1380000.0 -1.51 3585440.0 -1330000.0 -1.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L04 compound treatment 4390960.0 -459930.39548023 -0.508549796985599 -2.3585 -0.9064 3055484 HSCI1_000144 COc1cc(SC)ccc1c2nc3ccncc3[nH]2 2893760.0 -1850000.0 -2.03 3377440.0 -1540000.0 -1.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L05 compound treatment 5226960.0 376069.60451977 0.415824052748877 0.4522 0.8418 1907775 HSCI1_000145 CS(=O)(=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4ccc(F)cc4 4772560.0 26100.0 0.03 5257120.0 338000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L06 compound treatment 4942160.0 91269.6045197695 0.100917746045075 0.4259 0.7863 3176132 HSCI1_000146 COc1ccc(cc1)C(=C2C(=O)Nc3ccccc23)c4ccc(OC)cc4 4854040.0 108000.0 0.12 5436560.0 517000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L07 mock treatment 5048040.0 197149.60451977 0.217990357540154 0.5679 0.6377 4661760.0 -84700.0 -0.09 5774840.0 855000.0 0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L08 mock treatment 4921080.0 70189.6045197695 0.0776093719393299 0.761 0.713 4923480.0 177000.0 0.19 5962400.0 1040000.0 1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L09 mock treatment 4544040.0 -306850.39548023 -0.339287657132305 0.2394 0.3273 4852920.0 106000.0 0.12 5554520.0 635000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L10 mock treatment 5086920.0 236029.60451977 0.260980375814887 0.6153 0.625 4623400.0 -123000.0 -0.13 5855720.0 936000.0 0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L11 compound treatment 179560.0 -4671330.39548023 -5.16513835054035 -8.6356 -0.9994 3055486 HSCI1_000147 O=C1NC(=O)c2c1c3c4ccccc4n5C6CCC(O6)n7c8ccccc8c2c7c53 153360.0 -4590000.0 -5.03 174280.0 -4750000.0 -4.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L12 compound treatment 4508400.0 -342490.39548023 -0.378695173884144 -0.2025 -0.2908 3176133 HSCI1_000148 OC(=O)c1ccc(Cl)cc1NC(=O)Nc2cccc(c2)C(F)(F)F 4382080.0 -364000.0 -0.4 5344960.0 426000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L13 compound treatment 879720.0 -3971170.39548023 -4.39096419428426 -7.2676 -0.9986 3176134 HSCI1_000149 O/N=C\1/C(=C\2/C(=O)Nc3ccc(I)cc23)/Nc4ccccc14 803760.0 -3940000.0 -4.32 1054240.0 -3870000.0 -3.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L14 compound treatment 1184440.0 -3666450.39548023 -4.05403213747674 -6.6441 -0.9985 3055490 HSCI1_000150 COc1cc(ccc1c2nc3ccncc3[nH]2)S(=O)C 1183000.0 -3560000.0 -3.9 1380760.0 -3540000.0 -3.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L15 mock treatment 4980800.0 129909.60451977 0.14364239383663 0.4646 0.4675 4489760.0 -257000.0 -0.28 5858280.0 939000.0 0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L16 mock treatment 4570480.0 -280410.39548023 -0.310052675568933 0.4929 0.5048 5003760.0 257000.0 0.28 5798320.0 879000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L17 compound treatment 5369560.0 518669.60451977 0.573498348170093 1.0714 0.7543 3176135 HSCI1_000151 C[S+](O)c1ccc(CSc2nc(c([nH]2)c3ccc(F)cc3)c4ccncc4)cc1 4730920.0 -15600.0 -0.02 6214120.0 1290000.0 1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L18 compound treatment 3083040.0 -1767850.39548023 -1.95473047347449 -3.8305 -0.9875 2109556 HSCI1_000152 Nc1n[nH]c2nc3ccccc3nc12 2272000.0 -2470000.0 -2.71 2956440.0 -1960000.0 -1.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L19 compound treatment 5154080.0 303189.60451977 0.335239882690685 0.3834 0.5037 3176136 HSCI1_000153 C[C@@H]1C2NCC(C)C[C@H]2O[C@@]31CCC4C5CC=C6CC(O)CCC6(C)C5C(=O)C4=C3C 4481680.0 -265000.0 -0.29 5536160.0 617000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L20 compound treatment 4776280.0 -74610.3954802305 -0.082497486244345 0.1141 0.2194 3055494 HSCI1_000154 OB(O)c1ccc(cc1)C(=O)/C=C/c2ccc(I)cc2 4568520.0 -178000.0 -0.19 5392800.0 473000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L21 mock treatment 4797720.0 -53170.3954802305 -0.058791056413834 -0.0634 -0.2783 4583040.0 -163000.0 -0.18 5047000.0 128000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L22 mock treatment 5016400.0 165509.60451977 0.183005682174605 -0.0353 -0.0681 4342160.0 -404000.0 -0.44 5117320.0 198000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L23 mock treatment 4152040.0 -698850.39548023 -0.772726112988663 -0.7237 -0.7953 4307680.0 -439000.0 -0.48 4919240.0 -208.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 L24 mock treatment 4264720.0 -586170.39548023 -0.648134671136891 -0.6933 -0.9151 4516520.0 -230000.0 -0.25 4619760.0 -300000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M01 mock treatment 4472400.0 -378490.39548023 -0.418500746360748 -0.4785 -0.781 4339200.0 -407000.0 -0.45 4955080.0 35600.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M02 compound treatment 1310200.0 -3540690.39548023 -3.9149780042918 -6.3096 -0.9978 2095175 HSCI1_000155 Oc1ccc(/C=C(\C#N)/C(=O)NC2CCC(CC3CCC(CC3)NC(=O)\C(=C\c4ccc(O)c(O)c4)\C#N)CC2)cc1O 1381080.0 -3370000.0 -3.69 1603280.0 -3320000.0 -3.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M03 compound treatment 4209160.0 -641730.39548023 -0.709567937992451 -0.3696 -0.4855 552 HSCI1_000156 NC(=C(C#N)C#N)/C(=C/c1ccc(O)cc1)/C#N 4603040.0 -143000.0 -0.16 5145160.0 226000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M04 compound treatment 4199600.0 -651290.39548023 -0.720138528905682 -1.0974 -0.9703 613 HSCI1_000157 Oc1cc(/C=C/c2ccc(O)c(O)c2)oc(=O)c1 4044720.0 -702000.0 -0.77 4508760.0 -411000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M05 compound treatment 4578240.0 -272650.39548023 -0.301472363279531 -0.5217 -0.9682 657 HSCI1_000158 COc1ccc(/C=C(\C#N)/c2cccnc2)cc1OC 4384480.0 -362000.0 -0.4 4714480.0 -205000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M06 compound treatment 3167680.0 -1683210.39548023 -1.86114314974061 -3.3324 -0.9205 3176139 HSCI1_000159 CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)CCCCCCCCC)CO 2048920.0 -2700000.0 -2.95 3966320.0 -953000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M07 compound treatment 2536160.0 -2314730.39548023 -2.55942134780798 -4.4354 -1.0 671 HSCI1_000160 NC(=C(C#N)C#N)/C(=C/c1cc(O)c(O)c(O)c1)/C#N 2399000.0 -2350000.0 -2.57 2376360.0 -2540000.0 -2.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M08 compound treatment 3367720.0 -1483170.39548023 -1.63995685201228 -2.3215 -0.9621 3176140 HSCI1_000161 Nc1ncnc2n(cnc12)C3OC(CO)[C@H](O)[C@@H]3S 3306360.0 -1440000.0 -1.58 4118360.0 -801000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M09 mock treatment 4946560.0 95669.6045197695 0.105782871569993 0.1446 0.222 4403000.0 -344000.0 -0.38 5438360.0 519000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M10 mock treatment 5027160.0 176269.60451977 0.194903125503724 0.5806 0.6388 4679000.0 -67500.0 -0.07 5800920.0 881000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M11 mock treatment 4907120.0 56229.6045197695 0.06217365550118 0.3824 0.5856 4702560.0 -43900.0 -0.05 5565440.0 646000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M12 mock treatment 4867520.0 16629.6045197695 0.0183875257769153 0.7148 0.7719 5086040.0 340000.0 0.37 5764280.0 845000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M13 mock treatment 4780240.0 -70650.3954802305 -0.0781188732719185 0.6416 0.6305 4923040.0 177000.0 0.19 5912000.0 993000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M14 mock treatment 4628280.0 -222610.39548023 -0.246142617537051 0.3959 0.3834 4683920.0 -62600.0 -0.07 5916200.0 997000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M15 compound treatment 4392640.0 -458250.39548023 -0.506692203603358 -0.0774 -0.1069 585 HSCI1_000162 Oc1ccc(C(=O)/C=C/c2ccc(O)c(O)c2)c(O)c1 4629160.0 -117000.0 -0.13 5418760.0 499000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M16 compound treatment 5190480.0 339589.60451977 0.375487739305918 0.0915 0.1725 2024 HSCI1_000163 CN(N=O)c1cc(O)ccc1O 4426680.0 -320000.0 -0.35 5052240.0 133000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M17 compound treatment 4633040.0 -217850.39548023 -0.240879436287367 -0.038 -0.0479 569 HSCI1_000164 COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1 4343760.0 -403000.0 -0.44 5533280.0 614000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M18 compound treatment 4418520.0 -432370.39548023 -0.478076419834066 -0.6221 -0.7453 1890 HSCI1_000165 CN(N=O)c1ccc(O)c(O)c1 4126040.0 -620000.0 -0.68 4999200.0 79800.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M19 compound treatment 1811120.0 -3039770.39548023 -3.36110557748679 -6.9504 -0.9925 1008455 HSCI1_000166 BrCC(=O)c1ccc(Br)cc1 983120.0 -3760000.0 -4.12 379640.0 -4540000.0 -4.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M20 compound treatment 2448080.0 -2402810.39548023 -2.65681231513407 -4.5571 -1.0 3176141 HSCI1_000167 CCN(N=O)c1ccc(O)c(O)c1 2363840.0 -2380000.0 -2.61 2301840.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M21 compound treatment 4397240.0 -453650.39548023 -0.501605936009125 -0.3205 -0.3905 560 HSCI1_000168 Oc1ccc(/C=C(\C#N)/C(=O)Nc2ccccc2)cc1O 4303320.0 -443000.0 -0.49 5349760.0 430000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M22 compound treatment 4271800.0 -579090.39548023 -0.640306241883159 -2.481 -0.8995 566 HSCI1_000169 COc1cc(/C=C(\C#N)/C(=O)N)cc(CSc2nc3ccccc3s2)c1O 3538880.0 -1210000.0 -1.32 2593360.0 -2330000.0 -2.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M23 mock treatment 4539040.0 -311850.39548023 -0.344816208865167 -0.374 -0.9094 4650720.0 -95800.0 -0.1 4722120.0 -197000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 M24 mock treatment 4175600.0 -675290.39548023 -0.746675577223418 -0.6591 -0.7769 4378800.0 -368000.0 -0.4 4927160.0 7710.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N01 mock treatment 4219040.0 -631850.39548023 -0.698643519768316 -0.6587 -0.8392 4432400.0 -314000.0 -0.34 4821560.0 -97900.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N02 compound treatment 4543680.0 -307210.39548023 -0.339685712857071 0.6922 0.5201 837968 HSCI1_000170 Nc1ncnc2n(cnc12)C3CCCO3 5005320.0 259000.0 0.28 6170080.0 1250000.0 1.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N03 compound treatment 3781720.0 -1069170.39548023 -1.18219276853133 -2.136 -0.874 3176143 HSCI1_000171 CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](OC(=O)CCC(=O)O)[C@@]3(C)O[C@](C)(CC(=O)[C@@]32O)C=C 2831320.0 -1920000.0 -2.1 4500760.0 -419000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N04 compound treatment 880800.0 -3970090.39548023 -4.38977002710997 -8.1557 -0.9987 831810 HSCI1_000172 Brc1c(Br)c(Br)c2[nH]nnc2c1Br 206800.0 -4540000.0 -4.97 171600.0 -4750000.0 -4.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N05 compound treatment 4715960.0 -134930.39548023 -0.149193934349589 0.4639 0.3708 3054768 HSCI1_000173 C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@@]42OC(=O)/C=C\[C@H](O)CCC[C@@H](C)C/C=C\[C@H]4C(=O)C1=C 4507640.0 -239000.0 -0.26 6129360.0 1210000.0 1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N06 compound treatment 4826600.0 -24290.3954802305 -0.0268581416048248 0.1226 0.157 3054769 HSCI1_000174 Cn1sc(=O)n(Cc2ccccc2)c1=O 4363960.0 -383000.0 -0.42 5575160.0 656000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N07 compound treatment 1099480.0 -3751410.39548023 -4.14797328852153 -7.9029 -0.9977 621 HSCI1_000175 CS(=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4cccc(I)c4 276120.0 -4470000.0 -4.9 291400.0 -4630000.0 -4.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N08 compound treatment 4842680.0 -8210.39548023045 -0.00907831923194159 0.4446 0.4069 3054770 HSCI1_000176 c1ccc(cc1)c2n[nH]c3c2oc4ccccc34 4493040.0 -253000.0 -0.28 5972360.0 1050000.0 1.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N09 mock treatment 4434560.0 -416330.39548023 -0.460340825875045 -0.258 -0.3177 4320880.0 -426000.0 -0.47 5397360.0 478000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N10 mock treatment 4729400.0 -121490.39548023 -0.134333187291656 0.1006 0.1319 4423680.0 -323000.0 -0.35 5579200.0 660000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N11 mock treatment 5340600.0 489709.60451977 0.541476976533358 0.4286 0.5367 4470480.0 -276000.0 -0.3 5420800.0 501000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N12 mock treatment 4669600.0 -181290.39548023 -0.200454666016682 2.4592 0.7551 6274200.0 1530000.0 1.67 7696400.0 2780000.0 2.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N13 mock treatment 5890760.0 1039869.60451977 1.1497945808036 0.6622 0.5129 4366160.0 -380000.0 -0.42 5331640.0 412000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N14 mock treatment 4624840.0 -226050.39548023 -0.24994626112926 -0.1844 -0.2033 4152880.0 -594000.0 -0.65 5498040.0 579000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N15 compound treatment 2331600.0 -2519290.39548023 -2.78560545630281 -3.9255 -0.9795 3176144 HSCI1_000177 CC1C2C(Cc3ccccc3)NC(=O)C42OC(=O)O/C=C\C(C)(O)C(=O)C(C)C/C=C\C4C5OC51C 2591960.0 -2150000.0 -2.36 3271240.0 -1650000.0 -1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N16 compound treatment 4698200.0 -152690.39548023 -0.168831350104713 0.2906 0.5761 1056418 HSCI1_000178 Nc1ncnc2n(cnc12)C3CCC(CO)O3 5050720.0 304000.0 0.33 5257240.0 338000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N17 compound treatment 4832960.0 -17930.3954802305 -0.0198258238006247 0.7712 0.6456 2177 HSCI1_000179 CC(C)CC[C@@H](O)[C@](C)(O)C1CC[C@@]2(O)C3=CC(=O)[C@]4(O)C[C@@H](O)[C@@H](O)C[C@]4(C)C3[C@H](O)C[C@]12C 4905320.0 159000.0 0.17 6096840.0 1180000.0 1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N18 compound treatment 4719520.0 -131370.39548023 -0.145257605515791 0.1348 0.3381 3054771 HSCI1_000180 COc1ccc2NC(=O)/C(=C\c3c[nH]cn3)/c2c1 4753400.0 6900.0 0.01 5289320.0 370000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N19 compound treatment 4399880.0 -451010.39548023 -0.498686860694174 -0.8327 -0.9981 3176146 HSCI1_000181 CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)CCC)CO 4345840.0 -401000.0 -0.44 4416480.0 -503000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N20 compound treatment 3919200.0 -931690.39548023 -1.03017971008457 -0.7935 -0.6245 2127 HSCI1_000182 CC1(C)CCC2=C(O1)c3ccccc3C(=O)C2=O 4135440.0 -611000.0 -0.67 5243240.0 324000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N21 compound treatment 6001200.0 1150309.60451977 1.27190923147905 0.9938 0.7391 3054772 HSCI1_000183 CC(C)(O)/C=C/C(=O)[C@](C)(O)C1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4C(C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@@]12C 4759040.0 12500.0 0.01 5353520.0 434000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N22 compound treatment 4562280.0 -288610.39548023 -0.319119500410826 -0.5191 -0.8914 1937872 HSCI1_000184 [O-][N+](=O)c1ccccc1c2ccc(C=C3C(=O)N(C(=S)N(C3=O)c4ccccc4)c5ccccc5)o2 4312000.0 -435000.0 -0.48 4815680.0 -104000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N23 mock treatment 4243240.0 -607650.39548023 -0.671885329381265 -0.1848 -0.1248 4069960.0 -677000.0 -0.74 6008200.0 1090000.0 1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 N24 mock treatment 4074880.0 -776010.39548023 -0.858042723330185 -1.001 -0.946 4345720.0 -401000.0 -0.44 4484240.0 -435000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O01 mock treatment 4037520.0 -813370.39548023 -0.899352061878127 -1.1977 -0.8803 3827000.0 -920000.0 -1.01 4751920.0 -168000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O02 mock treatment 4388880.0 -462010.39548023 -0.51084967450647 -0.3857 -0.3718 4096120.0 -650000.0 -0.71 5472480.0 553000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O03 compound treatment 171760.0 -4679130.39548023 -5.17376289124362 -8.5667 -0.9994 5 HSCI1_000185 CC(C)(C)c1cc(C=C(C#N)C#N)cc(c1O)C(C)(C)C 249720.0 -4500000.0 -4.92 196600.0 -4720000.0 -4.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O04 compound treatment 2239120.0 -2611770.39548023 -2.88786154915382 -4.3385 -0.9929 2090 HSCI1_000186 CCOC(=O)C(C#N)C1C(=C(N)Oc2ccc(Br)cc12)C(=O)OCC 2487400.0 -2260000.0 -2.47 2774440.0 -2150000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O05 compound treatment 4260960.0 -589930.39548023 -0.652292142040004 -1.733 -0.9612 2107241 HSCI1_000187 ClC1=C(N2C(=O)CCC2=O)C(=O)c3ccccc3C1=O 3509000.0 -1240000.0 -1.36 3928880.0 -991000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O06 compound treatment 4170720.0 -680170.39548023 -0.752071443714691 -0.2451 -0.2773 651 HSCI1_000188 Nc1ncnc2n(ncc12)c3ccccc3 4636000.0 -111000.0 -0.12 5366360.0 447000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O07 compound treatment 1065480.0 -3785410.39548023 -4.18556744030499 -7.3608 -0.9996 562 HSCI1_000189 Oc1ccc(/C=C(\C#N)/C(=O)c2ccc(O)c(O)c2)cc1O 961960.0 -3780000.0 -4.14 516040.0 -4400000.0 -4.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O08 compound treatment 3910920.0 -939970.39548023 -1.03933499175419 -6.3015 -0.8923 3176147 HSCI1_000190 CS/C(=C(\C#N)/C(=C(\N)/SC)/[N+]#[C-])/N 114960.0 -4630000.0 -5.07 133480.0 -4790000.0 -4.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O09 compound treatment 3522720.0 -1328170.39548023 -1.46857174829357 -2.0823 -0.9828 3176148 HSCI1_000191 OCc1cc2ncnc(Nc3ccc(O)cc3)c2cc1CO 3631320.0 -1120000.0 -1.22 4005840.0 -914000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O10 compound treatment 4797520.0 -53370.3954802305 -0.0590121984831485 0.4186 0.4535 3054774 HSCI1_000192 Nc1ccc(cc1)c2cc(=O)c3cc(O)ccc3o2 4629440.0 -117000.0 -0.13 5828440.0 909000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O11 mock treatment 4400600.0 -450290.39548023 -0.497890749244642 -0.0299 -0.0368 4587600.0 -159000.0 -0.17 5537280.0 618000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O12 mock treatment 4766840.0 -84050.3954802305 -0.0929353919159879 0.4527 0.5093 4740240.0 -6260.0 -0.01 5800120.0 881000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O13 mock treatment 4768920.0 -81970.3954802305 -0.0906355143951174 0.2981 0.2742 4381360.0 -365000.0 -0.4 5922760.0 1000000.0 1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O14 mock treatment 4813160.0 -37730.3954802305 -0.0417188886627571 0.5862 0.6858 4962800.0 216000.0 0.24 5736760.0 817000.0 0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O15 compound treatment 4569040.0 -281850.39548023 -0.311644898467997 -0.1398 -0.2654 3176208 HSCI1_000193 COc1ccc(N=O)c(CCc2cc(OC)ccc2N=O)c1 4505720.0 -241000.0 -0.26 5251400.0 332000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O16 compound treatment 2347480.0 -2503410.39548023 -2.76804677599925 -4.5308 -0.9962 3054775 HSCI1_000194 CC(C)(C)OC(=O)NC(CC(=O)O)C(=O)OCCF 2203040.0 -2540000.0 -2.79 2633440.0 -2290000.0 -2.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O17 compound treatment 4054160.0 -796730.39548023 -0.880953041711164 -1.0498 -0.9424 1860 HSCI1_000195 CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23 4215200.0 -531000.0 -0.58 4565160.0 -354000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O18 compound treatment 4517760.0 -333130.39548023 -0.368345725040226 0.1596 0.2523 634 HSCI1_000196 OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O 4887200.0 141000.0 0.15 5408480.0 489000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O19 compound treatment 4208560.0 -642330.39548023 -0.710231364200394 -0.6031 -0.7899 589 HSCI1_000197 Nc1cc(Nc2ccc(cc2)S(=O)(=O)N)ncn1 4496800.0 -250000.0 -0.27 4858800.0 -60600.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O20 compound treatment 2634520.0 -2216370.39548023 -2.45066367811912 -6.2728 -0.9708 3054776 HSCI1_000198 Oc1ccc2[nH]c(cc2c1)C(=O)c3cc4ccccc4[nH]3 1286600.0 -3460000.0 -3.79 310760.0 -4610000.0 -4.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O21 compound treatment 4040400.0 -810490.39548023 -0.896167616079999 -0.2362 -0.2425 557 HSCI1_000199 Cc1cc2ncc(nc2cc1C)c3ccc(O)c(O)c3 4861400.0 115000.0 0.13 5279320.0 360000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O22 compound treatment 4164760.0 -686130.39548023 -0.758661477380263 0.1894 0.1618 1000586 HSCI1_000200 O/N=C\1/C(=C\2/C(=O)Nc3ccccc23)/Nc4ccccc14 4951360.0 205000.0 0.22 5778720.0 859000.0 0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O23 mock treatment 3861520.0 -989370.39548023 -1.09395708287486 -0.9223 -0.7471 4227680.0 -519000.0 -0.57 4983960.0 64500.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 O24 mock treatment 3238160.0 -1612730.39548023 -1.78321268451419 -1.684 -0.8544 4390360.0 -356000.0 -0.39 4178560.0 -741000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P01 mock treatment 3747560.0 -1103330.39548023 -1.21996383397024 -2.516 -0.9556 3779640.0 -967000.0 -1.06 2847880.0 -2070000.0 -2.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P02 mock treatment 4010960.0 -839930.39548023 -0.928719728683089 -1.1321 -0.8999 3995760.0 -751000.0 -0.82 4710200.0 -209000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P03 mock treatment 3676920.0 -1173970.39548023 -1.29807121285211 -1.1208 -0.7432 4053560.0 -693000.0 -0.76 5034680.0 115000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P04 mock treatment 4201160.0 -649730.39548023 -0.718413620765029 -0.5603 -0.6489 4344400.0 -402000.0 -0.44 5107120.0 188000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P05 mock treatment 4099360.0 -751530.39548023 -0.830974934046094 -0.7987 -0.8009 4242960.0 -504000.0 -0.55 4918480.0 -968.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P06 mock treatment 4047160.0 -803730.39548023 -0.88869301413717 -0.9465 -0.8644 4173200.0 -573000.0 -0.63 4797040.0 -122000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P07 mock treatment 3996800.0 -854090.39548023 -0.944376587190553 -0.8181 -0.7995 4395680.0 -351000.0 -0.38 4831280.0 -88200.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P08 mock treatment 4457280.0 -393610.39548023 -0.435219086800922 -0.4578 -0.6826 4297080.0 -449000.0 -0.49 5053480.0 134000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P09 mock treatment 2531760.0 -2319130.39548023 -2.56428647333289 -1.9829 -0.7319 3947600.0 -799000.0 -0.87 4924080.0 4630.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P10 mock treatment 4468440.0 -382450.39548023 -0.422879359333174 -0.5587 -0.7809 4220200.0 -526000.0 -0.58 4950800.0 31400.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P11 mock treatment 4794000.0 -56890.3954802305 -0.0629042989030831 -0.2353 -0.4145 4260560.0 -486000.0 -0.53 5106280.0 187000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P12 mock treatment 4503320.0 -347570.39548023 -0.384312182444731 -1.1809 -0.7202 3292240.0 -1450000.0 -1.59 4851160.0 -68300.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P13 mock treatment 4753400.0 -97490.3954802305 -0.10779613897392 -0.311 -0.4336 4136440.0 -610000.0 -0.67 5155880.0 236000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P14 mock treatment 4993320.0 142429.60451977 0.157485887375716 -0.3088 -0.3583 3983800.0 -763000.0 -0.84 5061760.0 142000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P15 mock treatment 4087720.0 -763170.39548023 -0.843845402480196 -0.6551 -0.6646 4312760.0 -434000.0 -0.47 5102920.0 183000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P16 mock treatment 4286840.0 -564050.39548023 -0.623676358270711 -0.7702 -0.7024 3938480.0 -808000.0 -0.88 5093280.0 174000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P17 mock treatment 4104640.0 -746250.39548023 -0.825136783416192 -0.8879 -0.682 3858160.0 -888000.0 -0.97 5178560.0 259000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P18 mock treatment 4426200.0 -424690.39548023 -0.46958456437239 -0.8387 -0.8972 4031320.0 -715000.0 -0.78 4720240.0 -199000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P19 mock treatment 4430960.0 -419930.39548023 -0.464321383122706 -1.08 -0.7869 3572280.0 -1170000.0 -1.29 4799480.0 -120000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P20 mock treatment 4231560.0 -619330.39548023 -0.68480002622923 -1.0108 -0.8535 3869480.0 -877000.0 -0.96 4814360.0 -105000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P21 mock treatment 4116880.0 -734010.39548023 -0.811602888774146 -1.3793 -0.9258 3662880.0 -1080000.0 -1.19 4530120.0 -389000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P22 mock treatment 4177480.0 -673410.39548023 -0.744596841771862 -1.1845 -0.9403 3877080.0 -869000.0 -0.95 4565760.0 -354000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P23 mock treatment 3157960.0 -1692930.39548023 -1.8718906543093 -2.0867 -0.9079 3621680.0 -1120000.0 -1.23 4410760.0 -509000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2104 P24 mock treatment 3220600.0 -1630290.39548023 -1.8026289582 -2.2478 -0.9514 3543960.0 -1200000.0 -1.32 4148440.0 -771000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A01 mock treatment 2969200.0 -1435817.92349727 -1.58759873380494 -2.468 -0.9905 3908160.0 -1050000.0 -1.15 3241160.0 -1530000.0 -1.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A02 mock treatment 3243600.0 -1161417.92349727 -1.28419181470549 -1.475 -0.9345 4495640.0 -460000.0 -0.5 4011680.0 -764000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A03 mock treatment 3418840.0 -986177.92349727 -1.09042713357216 -1.4882 -0.9222 4635400.0 -320000.0 -0.35 3643320.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A04 mock treatment 3521080.0 -883937.92349727 -0.977379307738601 -1.2067 -0.8933 4770480.0 -185000.0 -0.2 3869120.0 -907000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A05 mock treatment 3660920.0 -744097.92349727 -0.822756772873925 -1.0393 -0.8618 4862560.0 -92700.0 -0.1 3903400.0 -873000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A06 mock treatment 3807320.0 -597697.92349727 -0.660880778135735 -1.0066 -0.8672 4828800.0 -126000.0 -0.14 3835360.0 -941000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A07 mock treatment 3424720.0 -980297.92349727 -1.08392555673431 -1.2208 -0.865 4829920.0 -125000.0 -0.14 3885960.0 -890000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A08 mock treatment 3378600.0 -1026417.92349727 -1.13492091791823 -1.243 -0.8472 4870440.0 -84900.0 -0.09 3854360.0 -922000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A09 mock treatment 3502520.0 -902497.92349727 -0.997901291770984 -1.5658 -0.9647 4438360.0 -517000.0 -0.57 3632080.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A10 mock treatment 3667240.0 -737777.92349727 -0.815768683483588 -1.7253 -0.8871 4525240.0 -430000.0 -0.47 3080600.0 -1700000.0 -1.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A11 mock treatment 3445040.0 -959977.92349727 -1.06145752249196 -1.2141 -0.86 4847240.0 -108000.0 -0.12 3856360.0 -920000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A12 mock treatment 3705440.0 -699577.92349727 -0.773530548244525 -0.602 -0.5401 5335880.0 381000.0 0.42 4092520.0 -684000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A13 mock treatment 3785480.0 -619537.92349727 -0.685029492104874 -0.7902 -0.6724 5174880.0 220000.0 0.24 3855240.0 -921000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A14 mock treatment 3609320.0 -795697.92349727 -0.879811426757058 -0.9095 -0.7925 4992120.0 36800.0 0.04 4042880.0 -733000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A15 mock treatment 3679080.0 -725937.92349727 -0.802677072980171 -0.861 -0.7323 5097920.0 143000.0 0.16 3934360.0 -842000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A16 mock treatment 3800400.0 -604617.92349727 -0.668532293734015 -0.9519 -0.8728 4838320.0 -117000.0 -0.13 3927040.0 -849000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A17 mock treatment 3667000.0 -738017.92349727 -0.816034053966765 -0.8825 -0.7755 5025600.0 70300.0 0.08 3989400.0 -787000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A18 mock treatment 3684200.0 -720817.92349727 -0.797015836005721 -0.7814 -0.768 5021000.0 65700.0 0.07 4150040.0 -626000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A19 mock treatment 3505760.0 -899257.92349727 -0.994318790248089 -2.1085 -0.8765 4468560.0 -487000.0 -0.53 2658920.0 -2120000.0 -2.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A20 mock treatment 3741480.0 -663537.92349727 -0.733680747354057 -1.1557 -0.9637 4576200.0 -379000.0 -0.42 3926160.0 -850000.0 -0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A21 mock treatment 3680480.0 -724537.92349727 -0.80112907849497 -0.979 -0.9269 4722240.0 -233000.0 -0.26 4139000.0 -637000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A22 mock treatment 3641240.0 -763777.92349727 -0.844517152494469 -0.9084 -0.6628 5234880.0 280000.0 0.31 3744720.0 -1030000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A23 mock treatment 3610680.0 -794337.92349727 -0.87830766068572 -1.366 -0.9713 4479880.0 -475000.0 -0.52 3812440.0 -964000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 A24 mock treatment 3218440.0 -1186577.92349727 -1.31201148702525 -1.8863 -0.9888 4113680.0 -842000.0 -0.92 3746280.0 -1030000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B01 mock treatment 3479640.0 -925377.92349727 -1.02319994450056 -2.1331 -0.7233 5040320.0 85000.0 0.09 2021400.0 -2750000.0 -2.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B02 mock treatment 4036600.0 -368417.92349727 -0.407363509873628 -0.6249 -0.5072 5331800.0 377000.0 0.41 3692600.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B03 compound treatment 2497800.0 -1907217.92349727 -2.10883059117915 -3.0554 -0.9639 577 HSCI1_000201 CN1C(=O)C(=C(C1=O)c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 3029720.0 -1930000.0 -2.11 3705320.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B04 compound treatment 3686000.0 -719017.92349727 -0.795025557381891 -2.0876 -0.96 614 HSCI1_000202 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 3445200.0 -1510000.0 -1.65 3613120.0 -1160000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B05 compound treatment 3583680.0 -821337.92349727 -0.908161840043173 -1.217 -0.9103 907102 HSCI1_000203 NCCCCCCNS(=O)(=O)c1cccc2ccccc12 4089160.0 -866000.0 -0.95 4525720.0 -250000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B06 compound treatment 4319640.0 -85377.9234972699 -0.094403253379793 0.1882 0.3261 1012954 HSCI1_000204 OC(Cc1ccncc1)C(Cl)(Cl)Cl 5460800.0 506000.0 0.55 4643400.0 -133000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B07 compound treatment 3097600.0 -1307417.92349727 -1.44562552530506 -2.8937 -0.9483 3176210 HSCI1_000205 CCCC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c3cc4ccccc4[nH]3 3926520.0 -1030000.0 -1.13 2345080.0 -2430000.0 -2.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B08 compound treatment 2403120.0 -2001897.92349727 -2.21351924679262 -3.6575 -0.9911 321 HSCI1_000206 O=c1cc(oc2c(cccc12)c3ccccc3)N4CCOCC4 3380440.0 -1570000.0 -1.72 2387840.0 -2390000.0 -2.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B09 compound treatment 689640.0 -3715377.92349727 -4.10813181143739 -7.5131 -0.9979 3176211 HSCI1_000207 C[C@@H](O)[C@]1(C)CC[C@@H](O1)[C@]2(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)/C(=C/C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(=O)O)/O)O2 633680.0 -4320000.0 -4.73 618760.0 -4160000.0 -4.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B10 compound treatment 4301360.0 -103657.92349727 -0.114615638515135 0.1259 0.184 3103895 HSCI1_000208 C[C@@H]1CC2C3CCC4=CC(=O)C=CC4(C)[C@@]3(F)[C@@H](O)CC2(C)[C@@]1(O)C(=O)CO 5515520.0 560000.0 0.61 4496280.0 -280000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B11 mock treatment 3948640.0 -456377.92349727 -0.504621791958131 -0.1939 -0.2259 5473800.0 519000.0 0.57 4378520.0 -398000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B12 mock treatment 4357200.0 -47817.9234972699 -0.0528727727625359 0.3895 0.6136 5525160.0 570000.0 0.62 4879160.0 103000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B13 mock treatment 4394520.0 -10497.9234972699 -0.0116076626284562 0.0832 0.097 5575800.0 621000.0 0.68 4254160.0 -522000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B14 mock treatment 4256240.0 -148777.92349727 -0.164505289352479 0.2264 0.4407 5394280.0 439000.0 0.48 4851720.0 75600.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B15 compound treatment 2431560.0 -1973457.92349727 -2.1820728445361 -3.703 -0.9998 1940 HSCI1_000209 NSC(=S)N1CCCC1 3055040.0 -1900000.0 -2.08 2633120.0 -2140000.0 -2.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B16 compound treatment 4102840.0 -302177.92349727 -0.334121256516676 0.1852 0.1695 1000071 HSCI1_000210 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 5856000.0 901000.0 0.99 4445840.0 -330000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B17 compound treatment 4563040.0 158022.07650273 0.174726644975915 1.0425 0.8247 3176212 HSCI1_000211 Nc1ncnc2n(cnc12)C3OC(CO)[C@H](O)[C@@H]3O 6014680.0 1060000.0 1.16 5245200.0 469000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B18 compound treatment 4437320.0 32302.0765027301 0.03571674020484 0.3826 0.5329 831767 HSCI1_000212 NCCCNCCCCNCCCN 5605480.0 650000.0 0.71 4691360.0 -84700.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B19 compound treatment 3984800.0 -420217.92349727 -0.464639305826075 -0.8782 -0.8925 3054778 HSCI1_000213 NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N 4757560.0 -198000.0 -0.22 3939240.0 -837000.0 -0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B20 compound treatment 4418200.0 13182.0765027301 0.0145755583783768 0.4861 0.707 2293 HSCI1_000214 CSC(=N)N 5566080.0 611000.0 0.67 4934000.0 158000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B21 compound treatment 3903000.0 -502017.92349727 -0.555086412175693 -0.1104 -0.1694 1001920 HSCI1_000215 CNC[C@H](O)c1ccc(O)c(O)c1 5266440.0 311000.0 0.34 4799080.0 23000.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B22 compound treatment 4107400.0 -297617.92349727 -0.329079217336307 -0.051 -0.0879 3054779 HSCI1_000216 CN/C(=N\C)/NCCC[C@H](N)C(=O)O 5353160.0 398000.0 0.44 4581840.0 -194000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B23 mock treatment 4249880.0 -155137.92349727 -0.17153760715668 -0.4896 -0.761 4901160.0 -54100.0 -0.06 4161040.0 -615000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 B24 mock treatment 3458600.0 -946417.92349727 -1.04646409019244 -1.5872 -0.9664 4430240.0 -525000.0 -0.57 3652440.0 -1120000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C01 mock treatment 3920240.0 -484777.92349727 -0.536023965800786 -0.7642 -0.9623 4713400.0 -242000.0 -0.26 4255320.0 -521000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C02 mock treatment 3845560.0 -559457.92349727 -0.618598414482808 -0.5085 -0.4311 5472840.0 518000.0 0.57 3950200.0 -826000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C03 compound treatment 4118720.0 -286297.92349727 -0.316562576213108 -0.0463 -0.0841 2022 HSCI1_000217 CC1(C)C(C=C(Br)Br)C1C(=O)OC(C#N)c2cccc(Oc3ccccc3)c2 5332840.0 378000.0 0.41 4599680.0 -176000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C04 compound treatment 4600480.0 195462.07650273 0.216124440351583 0.5109 0.9822 3176214 HSCI1_000218 COc1ccc2c(cc(C)c3nnc(SCC(=O)Nc4cccc(c4)C(=O)C)n32)c1 5251120.0 296000.0 0.32 5119680.0 344000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C05 compound treatment 3847600.0 -557417.92349727 -0.616342765375801 -1.4023 -0.9387 3054780 HSCI1_000219 CCCCc1c([nH]c2nccnc12)c3ccc(O)cc3 3832440.0 -1120000.0 -1.23 4195360.0 -581000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C06 compound treatment 4340200.0 -64817.9234972699 -0.0716698486542657 -0.2138 -0.605 3054781 HSCI1_000220 NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+](=O)[O-])cc1 4641960.0 -313000.0 -0.34 4820480.0 44400.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C07 compound treatment 3839960.0 -565057.92349727 -0.624790392423613 -0.3191 -0.5089 360 HSCI1_000221 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 4997080.0 41800.0 0.05 4802360.0 26300.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C08 compound treatment 3712680.0 -692337.92349727 -0.765525205335341 -0.5334 -0.6847 2260 HSCI1_000222 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(CO)c8c1c2c(c34)c(c65)c78 4941920.0 -13400.0 -0.01 4632840.0 -143000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C09 compound treatment 3930440.0 -474577.92349727 -0.524745720265748 -0.2453 -0.3035 3054782 HSCI1_000223 O=c1cc(oc2c1ccc3ccccc32)N4CCOCC4 5395240.0 440000.0 0.48 4395520.0 -381000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C10 compound treatment 3298280.0 -1106737.92349727 -1.22373157295492 -1.9605 -0.9503 3176215 HSCI1_000224 C1CCC(CC1)n2cnc3c(Nc4ccc(cc4)N5CCOCC5)nc(Oc6cccc7ccccc67)nc23 4371760.0 -584000.0 -0.64 3248560.0 -1530000.0 -1.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C11 mock treatment 3916560.0 -488457.92349727 -0.540092979876172 0.1518 0.1399 5807000.0 852000.0 0.93 4646920.0 -129000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C12 mock treatment 4201160.0 -203857.92349727 -0.225407815241684 -0.5912 -0.9723 4586360.0 -369000.0 -0.4 4382960.0 -393000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C13 mock treatment 4359040.0 -45977.9234972699 -0.0508382657248428 0.299 0.4786 5521840.0 567000.0 0.62 4724480.0 -51600.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C14 mock treatment 4747960.0 342942.07650273 0.379194602264072 0.9992 0.9367 5755920.0 801000.0 0.88 5249120.0 473000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C15 mock treatment 4056520.0 -348497.92349727 -0.385337759769907 0.1274 0.1937 5436480.0 481000.0 0.53 4854800.0 78700.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C16 mock treatment 4400080.0 -4937.92349726986 -0.00545991310151396 0.5668 0.804 5342480.0 387000.0 0.42 5337240.0 561000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C17 compound treatment 4653320.0 248302.07650273 0.274550175064466 0.9079 0.913 3176216 HSCI1_000225 CCCCCCCCCCCCCCCCC(=C)OOCC(COP(=O)(ON)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(=O)(O)ON)[C@H](OP(=O)(O)ON)[C@H]1O)OOC(=C)CC/C=C/C/C=C/C\C=C\C\C=C\CCCCC 5720000.0 765000.0 0.84 5234960.0 459000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C18 compound treatment 4558440.0 153422.07650273 0.169640377381682 0.4849 0.6655 907140 HSCI1_000226 NCCCCNS(=O)(=O)c1ccc2ccccc2c1 5601480.0 646000.0 0.71 4738800.0 -37300.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C19 compound treatment 3475080.0 -929937.92349727 -1.02824198368093 -0.9331 -0.7885 3054783 HSCI1_000227 Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=S)(O)O)[C@H](O)[C@@H]3O 4953400.0 -1900.0 0.0 4192360.0 -584000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C20 compound treatment 1407080.0 -2997937.92349727 -3.31485098039253 -5.7128 -0.9999 2081802 HSCI1_000228 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccc(O)c(CN(C)C)c5cc4Cn3c2=O 2001440.0 -2950000.0 -3.23 1442840.0 -3330000.0 -3.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C21 compound treatment 3205920.0 -1199097.92349727 -1.32585498056434 -2.1131 -0.9879 3176218 HSCI1_000229 Nc1nc2n(C3OC4COP(O)(O)OC4C3O)c(Br)nc2c(=O)[nH]1 3692680.0 -1260000.0 -1.38 3828040.0 -948000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C22 compound treatment 2553440.0 -1851577.92349727 -2.04730886749586 -3.5538 -0.9992 3054784 HSCI1_000230 Nc1nc(Cl)nc2n(cnc12)C3C[C@@H](O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3 3172000.0 -1780000.0 -1.95 2628600.0 -2150000.0 -2.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C23 compound treatment 3375520.0 -1029497.92349727 -1.13832650578567 -2.1978 -0.9949 1338 HSCI1_000231 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 3636360.0 -1320000.0 -1.44 3556480.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 C24 mock treatment 3869920.0 -535097.92349727 -0.591663310440306 -0.6554 -0.7618 5025080.0 69800.0 0.08 4158440.0 -618000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D01 mock treatment 4200080.0 -204937.92349727 -0.226601982415982 -0.5066 -0.7893 4907160.0 -48100.0 -0.05 4180040.0 -596000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D02 mock treatment 4142720.0 -262297.92349727 -0.290025527895372 -0.0221 -0.0563 5196400.0 241000.0 0.26 4763840.0 -12300.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D03 compound treatment 901760.0 -3503257.92349727 -3.87358853272246 -6.5511 -0.9995 3176219 HSCI1_000232 O/N=C/1\C(=C/2\C(=O)Nc3cc(Br)ccc23)\Nc4ccccc14 1424880.0 -3530000.0 -3.87 1181880.0 -3590000.0 -3.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D04 compound treatment 2146720.0 -2258297.92349727 -2.49702337965376 -3.4514 -0.9632 3054785 HSCI1_000233 O=C1NC(=O)c2c1ccc(Nc3ccccc3)c2Nc4ccccc4 2888280.0 -2070000.0 -2.26 3563040.0 -1210000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D05 compound treatment 2641280.0 -1763737.92349727 -1.95018327065295 -3.1334 -0.9803 1277018 HSCI1_000234 COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC 2975840.0 -1980000.0 -2.17 3471400.0 -1300000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D06 compound treatment 4042120.0 -362897.92349727 -0.401259988760549 -0.052 -0.0744 1919 HSCI1_000235 CCCCCc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1 5437880.0 483000.0 0.53 4559640.0 -216000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D07 compound treatment 3840840.0 -564177.92349727 -0.62381736731863 -0.2134 -0.195 3176221 HSCI1_000236 C1C[C@H](N/C/2=N/CCCCCCCCCCC2)[C@@H](C1)c3ccccc3 5640200.0 685000.0 0.75 4282040.0 -494000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D08 compound treatment 4195440.0 -209577.92349727 -0.231732478424078 0.1304 0.213 3054786 HSCI1_000237 OCC1OC([C@@H](O)[C@H]1O)n2cnc3cc(Cl)c(Cl)cc23 5464640.0 509000.0 0.56 4676320.0 -99800.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D09 compound treatment 2218480.0 -2186537.92349727 -2.41767760518373 -3.7028 -0.9849 3176222 HSCI1_000238 COc1cc2ncnc(Nc3ccc(OCc4ccccc4)cc3)c2cc1OC 3488280.0 -1470000.0 -1.61 2395440.0 -2380000.0 -2.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D10 compound treatment 4671280.0 266262.07650273 0.294408732888905 0.6068 0.6918 407 HSCI1_000239 [O-][N+](=O)c1cccc2c(Br)n[nH]c12 5707240.0 752000.0 0.82 4709400.0 -66700.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D11 mock treatment 4583400.0 178382.07650273 0.197238907632127 0.4639 0.671 5558280.0 603000.0 0.66 4722120.0 -54000.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D12 mock treatment 4115760.0 -289257.92349727 -0.319835478838962 0.3097 0.4114 5548200.0 593000.0 0.65 4982280.0 206000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D13 mock treatment 4367120.0 -37897.9234972699 -0.0419041261245383 0.359 0.5576 5541600.0 586000.0 0.64 4797640.0 21500.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D14 mock treatment 4444960.0 39942.0765027301 0.0441643672526527 0.6389 0.7397 5713960.0 759000.0 0.83 5006800.0 231000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D15 mock treatment 4469920.0 64902.0765027301 0.0717628975030983 0.6353 0.6684 5817360.0 862000.0 0.94 4860400.0 84300.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D16 mock treatment 4651360.0 246342.07650273 0.272382982785184 0.6378 0.9325 5475600.0 520000.0 0.57 5037720.0 262000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D17 compound treatment 4192520.0 -212497.92349727 -0.234961152636069 0.0438 0.1018 3054787 HSCI1_000240 N/N=C(/N)\NO 5281720.0 326000.0 0.36 4729640.0 -46500.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D18 compound treatment 4348560.0 -56457.9234972699 -0.0624261101569209 -0.1954 -0.7125 907294 HSCI1_000241 CN(C)C(=N)NCCC[C@H](N)C(=O)O 4711520.0 -244000.0 -0.27 4767000.0 -9090.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D19 compound treatment 4542000.0 136982.07650273 0.151462499284033 0.5792 0.8882 3176223 HSCI1_000242 CSC(=N)NCCC[C@H](N)C(=O)O 5472520.0 517000.0 0.57 5060320.0 284000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D20 compound treatment 4534920.0 129902.07650273 0.1436340700303 0.6177 0.8248 3054789 HSCI1_000243 CNC(=N)NCCC[C@@H](N)C=O 5593600.0 638000.0 0.7 5002560.0 226000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D21 compound treatment 4039520.0 -365497.92349727 -0.404134835661637 0.0555 0.0657 3176224 HSCI1_000244 OP(=O)(O)C(Cl)(Cl)P(=O)(O)O 5605520.0 650000.0 0.71 4565120.0 -211000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D22 compound treatment 4185400.0 -219617.92349727 -0.242833810303664 0.3073 0.5072 3176225 HSCI1_000245 CNC(=N)NCCC[C@H](N)C=O 5365880.0 411000.0 0.45 5100360.0 324000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D23 compound treatment 4372640.0 -32377.9234972699 -0.035800605011459 0.4162 0.7716 2215 HSCI1_000246 CCCNC(=N)NCCCC(N)C(=O)O 5263000.0 308000.0 0.34 5194280.0 418000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 D24 mock treatment 4237880.0 -167137.92349727 -0.184806131315548 -0.3194 -0.9673 4841120.0 -114000.0 -0.13 4533560.0 -243000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E01 mock treatment 4163360.0 -241657.92349727 -0.267203666342118 -0.4501 -0.7362 4988440.0 33100.0 0.04 4229360.0 -547000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E02 mock treatment 4223360.0 -181657.92349727 -0.200861045547778 -0.1041 -0.4225 4872920.0 -82400.0 -0.09 4886400.0 110000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E03 mock treatment 3845600.0 -559417.92349727 -0.618554186068945 -0.5165 -0.7483 4981600.0 26300.0 0.03 4472280.0 -304000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E04 mock treatment 4502120.0 97102.0765027301 0.107366770662728 0.1703 0.7425 5139880.0 185000.0 0.2 4761600.0 -14500.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E05 compound treatment 3989120.0 -415897.92349727 -0.459862637128883 -0.7644 -0.9941 3176226 HSCI1_000247 CCCCc1c([nH]c2nccnc12)c3ccc(OC)cc3 4612640.0 -343000.0 -0.38 4289000.0 -487000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E06 compound treatment 4310960.0 -94057.9234972699 -0.104000819188041 0.1015 0.4525 2371 HSCI1_000248 CCCCCCCCNC(=O)C(Cc1ccc(OCc2ccncc2)cc1)NC(=O)C3CCC(CN)CC3 5095080.0 140000.0 0.15 4902320.0 126000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E07 compound treatment 1514040.0 -2890977.92349727 -3.19658420172315 -5.3479 -0.9992 1989 HSCI1_000249 Clc1[nH]c2ccccc2c1/C=C\3/C(=O)Nc4ccccc34 2297840.0 -2660000.0 -2.91 1631320.0 -3140000.0 -3.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E08 compound treatment 1037080.0 -3367937.92349727 -3.7239638086243 -6.4226 -0.9977 1416171 HSCI1_000250 OC(CN1CCNCC1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24 1857960.0 -3100000.0 -3.39 782040.0 -3990000.0 -4.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E09 mock treatment 4451960.0 46942.0765027301 0.0519043396786591 0.6373 0.8015 5613840.0 659000.0 0.72 5105720.0 330000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E10 mock treatment 4364040.0 -40977.9234972699 -0.0453097139919811 0.774 0.7692 5732440.0 777000.0 0.85 5309040.0 533000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E11 compound treatment 4552680.0 147662.07650273 0.163271485785425 0.525 0.9338 663 HSCI1_000251 Fc1ccc(cc1)c2nc3SCCn3c2c4ccncc4 5363960.0 409000.0 0.45 5073560.0 297000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E12 compound treatment 3176480.0 -1228537.92349727 -1.35840709316743 -2.2813 -0.9982 1000089 HSCI1_000252 COC1C(C)OC(OC2CC(C)(O)C(C(=O)OC)c3cc4C(=O)c5c6OC7OC(C)(C(O)C(C7O)N(C)C)c6cc(O)c5C(=O)c4c(O)c23)C(OC)C1(C)OC 3853600.0 -1100000.0 -1.21 3394560.0 -1380000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E13 compound treatment 4279680.0 -125337.92349727 -0.138587438828824 -0.1094 -0.3745 3054791 HSCI1_000253 Nc1nc2n(cnc2c(=O)[nH]1)C3OC4COP(O)(O)OC4C3O 5096440.0 141000.0 0.15 4571440.0 -205000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E14 compound treatment 4745520.0 340502.07650273 0.376496669018435 1.153 0.9548 3176276 HSCI1_000254 NCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N[N+](=O)[O-])C(=O)N 5658200.0 703000.0 0.77 5623840.0 848000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E15 mock treatment 4687000.0 281982.07650273 0.311790499537022 1.1874 0.9029 5966240.0 1010000.0 1.11 5411480.0 635000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E16 mock treatment 4586280.0 181262.07650273 0.200423353430256 1.0337 0.8939 5798640.0 843000.0 0.92 5440160.0 664000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E17 mock treatment 4770560.0 365542.07650273 0.404183656096607 0.6627 0.9891 5233480.0 278000.0 0.3 5213560.0 437000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E18 mock treatment 4342440.0 -62577.9234972699 -0.0691930574779437 0.0554 0.1502 5252280.0 297000.0 0.33 4616640.0 -159000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E19 compound treatment 4400240.0 -4777.92349726986 -0.00528299944606239 0.0518 0.5797 1000095 HSCI1_000255 CC(O)C(O)[C@H]1CNc2nc(N)[nH]c(=O)c2N1 5036560.0 81300.0 0.09 4782080.0 5990.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E20 compound treatment 4227200.0 -177817.92349727 -0.19661511781694 -0.1656 -0.2752 3054834 HSCI1_000256 NCCNC[C@@H](N)CCCNC(=N)N[N+](=O)[O-] 5279000.0 324000.0 0.35 4333000.0 -443000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E21 compound treatment 4669080.0 264062.07650273 0.291976170126446 0.6111 0.7716 423 HSCI1_000257 COC(=O)[C@@H](N)CCCNC(=N)N[N+](=O)[O-] 5626880.0 672000.0 0.74 4806920.0 30800.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E22 compound treatment 4955920.0 550902.07650273 0.609138125937256 0.3419 0.4465 2114444 HSCI1_000258 O=c1n(CCN2CCCCC2)c(=O)c3ccc4c5ccc6c(=O)n(CCN7CCCCC7)c(=O)c8ccc(c9ccc1c3c94)c5c86 4648120.0 -307000.0 -0.34 5094360.0 318000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E23 compound treatment 4456880.0 51862.0765027301 0.057344434583795 0.1662 0.534 832002 HSCI1_000259 CC(=N)NCCC[C@H](N)C(=O)O 5227720.0 272000.0 0.3 4708560.0 -67500.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 E24 mock treatment 4262360.0 -142657.92349727 -0.157738342031457 0.283 0.3766 4880200.0 -75100.0 -0.08 5503560.0 727000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F01 mock treatment 4301000.0 -104017.92349727 -0.115013694239901 -0.3551 -0.5453 5072160.0 117000.0 0.13 4150360.0 -626000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F02 mock treatment 4369880.0 -35137.9234972699 -0.0388523655679986 0.166 0.3397 5381240.0 426000.0 0.47 4636440.0 -140000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F03 mock treatment 4564080.0 159062.07650273 0.17587658373635 -0.3451 -0.5945 4655320.0 -300000.0 -0.33 4332520.0 -444000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F04 mock treatment 4203880.0 -201137.92349727 -0.222400283099007 0.142 0.2102 5520840.0 566000.0 0.62 4625560.0 -151000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F05 compound treatment 5018480.0 613462.07650273 0.678311365218821 -0.5375 -0.4033 3176278 HSCI1_000260 CC(=O)O/N=C/1\C(=C/2\C(=O)Nc3cc(Br)ccc23)\Nc4ccccc14 4126600.0 -829000.0 -0.91 4076880.0 -699000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F06 compound treatment 4482160.0 77142.0765027301 0.0852967921451437 0.556 0.8765 1505 HSCI1_000261 CC(C)Cn1c(=O)n(C)c(=O)c2[nH]cnc12 5420200.0 465000.0 0.51 5143400.0 367000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F07 compound treatment 1975520.0 -2429497.92349727 -2.68632099098695 -4.4796 -0.9992 3054836 HSCI1_000262 COc1ccc(CNc2nc(nc3n(cnc23)C(C)C)N(CCO)CCO)cc1 2720920.0 -2230000.0 -2.45 2159800.0 -2620000.0 -2.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F08 compound treatment 1507080.0 -2897937.92349727 -3.2042799457353 -5.5124 -0.9943 1980 HSCI1_000263 CC1(C2CCC(O2)C1(C)C(=O)O)C(=O)O 1678360.0 -3280000.0 -3.59 2031120.0 -2740000.0 -2.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F09 mock treatment 4424480.0 19462.0765027301 0.0215194193548511 0.1807 0.2832 5478160.0 523000.0 0.57 4496000.0 -280000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F10 mock treatment 4633800.0 228782.07650273 0.252966709099373 0.66 0.9442 5470600.0 515000.0 0.56 5100720.0 325000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F11 compound treatment 3448720.0 -956297.92349727 -1.05738850841658 -1.594 -0.8596 832084 HSCI1_000264 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c4nc[nH]c4n2)cc1 4779680.0 -176000.0 -0.19 3270280.0 -1510000.0 -1.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F12 compound treatment 4584240.0 179222.07650273 0.198167704323248 1.0408 0.8975 445 HSCI1_000265 NC(=O)c1cccc(N)c1 5775160.0 820000.0 0.9 5480320.0 704000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F13 compound treatment 4636720.0 231702.07650273 0.256195383311365 0.2559 0.6442 2194 HSCI1_000266 OS(=O)(=O)c1cc(c2c(NC(=O)c3cccc(c3)[N+](=O)[O-])ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 5217080.0 262000.0 0.29 4676760.0 -99300.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F14 compound treatment 4360040.0 -44977.9234972699 -0.0497325553782705 0.5386 0.7346 2025 HSCI1_000267 NCCCC(N)(C(F)F)C(=O)O 5551680.0 596000.0 0.65 5104440.0 328000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F15 mock treatment 4939080.0 534062.07650273 0.590517963700978 0.7378 0.9142 5435440.0 480000.0 0.53 4937040.0 161000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F16 mock treatment 4869200.0 464182.07650273 0.513250924682502 1.1559 0.9067 5960120.0 1000000.0 1.1 5163120.0 387000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F17 mock treatment 4730840.0 325822.07650273 0.360264841130753 0.4609 0.7104 5440600.0 485000.0 0.53 4683040.0 -93100.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F18 mock treatment 4612040.0 207022.07650273 0.228906451957959 0.8062 0.9315 5408640.0 453000.0 0.5 5444720.0 669000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F19 compound treatment 4280960.0 -124057.92349727 -0.137172129585211 -0.515 -0.9341 2259 HSCI1_000268 CN1CCc2cc3OCOc3cc2C(=O)Cc4ccc5OCOc5c4C1 4620440.0 -335000.0 -0.37 4389280.0 -387000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F20 compound treatment 4408960.0 3942.07650273014 0.00435879477604842 0.2587 0.5827 2674 HSCI1_000269 N[C@@H](CCC(=O)O)C(=O)O 5360760.0 405000.0 0.44 4775840.0 -252.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F21 compound treatment 1851200.0 -2553817.92349727 -2.82378290127282 -4.8718 -0.9998 3176279 HSCI1_000270 CC[C@]1(O)C[C@H]2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)[C@@H]7[C@@]86CCN9CC=C[C@@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC 2456440.0 -2500000.0 -2.74 1908440.0 -2870000.0 -2.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F22 compound treatment 4276320.0 -128697.92349727 -0.142302625593307 -0.3524 -0.3439 2129 HSCI1_000271 OCC(O)C1OC(=O)C(=C1O)O 5361000.0 406000.0 0.44 3867040.0 -909000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F23 compound treatment 2057120.0 -2347897.92349727 -2.59609502670664 -4.8641 -0.9981 1000078 HSCI1_000272 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](OC5CC(N)C(O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO 2201440.0 -2750000.0 -3.02 1973200.0 -2800000.0 -2.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 F24 mock treatment 4114640.0 -290377.92349727 -0.321073874427123 -0.6225 -0.9732 4699560.0 -256000.0 -0.28 4300720.0 -475000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G01 mock treatment 4129040.0 -275977.92349727 -0.305151645436481 -0.2256 -0.7146 4950920.0 -4380.0 0.0 4695560.0 -80500.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G02 compound treatment 3727760.0 -677257.92349727 -0.74885109330903 -1.3286 -0.989 25 HSCI1_000273 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)OCC[N+](C)(C)C 4118760.0 -837000.0 -0.92 4142120.0 -634000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G03 mock treatment 4361200.0 -43817.9234972699 -0.0484499313762466 0.1652 0.6832 5116240.0 161000.0 0.18 4933920.0 158000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G04 mock treatment 4342520.0 -62497.9234972699 -0.0691046006502179 -0.2729 -0.7757 4896160.0 -59100.0 -0.06 4438440.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G05 mock treatment 4484600.0 79582.0765027301 0.0879947253907803 0.3795 0.5593 5563360.0 608000.0 0.67 4679920.0 -96200.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G06 mock treatment 4215160.0 -189857.92349727 -0.209927870389671 0.9276 0.6884 6009800.0 1050000.0 1.15 5435440.0 659000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G07 compound treatment 4625720.0 220702.07650273 0.244032569499069 0.0662 0.2443 3054838 HSCI1_000274 CC(C)(c1ccc(NS(=O)(=O)C(F)(F)F)cc1)c2ccc(cc2)C(C)(C)c3cccc(NS(=O)(=O)C(F)(F)F)c3 4848240.0 -107000.0 -0.12 4764000.0 -12100.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G08 compound treatment 4672920.0 267902.07650273 0.296222097857283 0.7917 0.9062 546 HSCI1_000275 Cc1ncc2ccccc2c1C#N 5244320.0 289000.0 0.32 5532000.0 756000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G09 compound treatment 3487840.0 -917177.92349727 -1.01413311965867 -1.2076 -0.7761 1947905 HSCI1_000276 Clc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1Cl 5045160.0 89900.0 0.1 3604360.0 -1170000.0 -1.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G10 compound treatment 4818920.0 413902.07650273 0.457655808456845 0.6097 0.9472 636 HSCI1_000277 C/C(=C(\C#N)/C(=O)Nc1cccc(F)c1)/O 5124720.0 169000.0 0.19 5187520.0 411000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G11 compound treatment 3480880.0 -924137.92349727 -1.02182886367081 -1.5255 -0.8199 3176281 HSCI1_000278 COc1ccc(CNC(=O)Nc2ncc(s2)[N+](=O)[O-])cc1 4894160.0 -61100.0 -0.07 3228120.0 -1550000.0 -1.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G12 compound treatment 5889560.0 1484542.07650273 1.64147353391106 2.8543 0.9992 3054840 HSCI1_000279 CC1OC(C[C@H]1O)n2cnc3c(N)ncnc23 6537400.0 1580000.0 1.73 6340240.0 1560000.0 1.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G13 compound treatment 210120.0 -4194897.92349727 -4.63834203682576 -8.2778 -0.9987 2319 HSCI1_000280 CN(C)CC1Cc2ccccc2C1=O 278120.0 -4680000.0 -5.12 215280.0 -4560000.0 -4.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G14 compound treatment 4394880.0 -10137.9234972699 -0.0112096069036901 0.7954 0.8098 3176282 HSCI1_000281 N[C@@H](CCN/C(=N/O)/N)C(=O)O 5579880.0 625000.0 0.68 5478520.0 702000.0 0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G15 compound treatment 3120400.0 -1284617.92349727 -1.42041532940321 -1.8318 -0.9715 2145 HSCI1_000282 NC(=N)NCCS 4187640.0 -768000.0 -0.84 3867720.0 -908000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G16 compound treatment 5518800.0 1113782.07650273 1.23152036581589 2.5849 0.9836 3583 HSCI1_000283 Cn1cc(NC(=O)c2cc(NC(=O)CNC(=N)N)cn2C)cc1C(=O)NCCC(=N)N 6662840.0 1710000.0 1.87 6146960.0 1370000.0 1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G17 mock treatment 5099000.0 693982.07650273 0.767343162324826 1.1888 0.9777 5697120.0 742000.0 0.81 5253800.0 478000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G18 mock treatment 5046680.0 641662.07650273 0.709492396992161 1.1144 0.9773 5659480.0 704000.0 0.77 5224080.0 448000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G19 mock treatment 4823640.0 418622.07650273 0.462874761292667 0.8342 0.9347 5607960.0 653000.0 0.71 5042320.0 266000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G20 mock treatment 4935240.0 530222.07650273 0.58627203597014 0.8558 0.8233 5738400.0 783000.0 0.86 4814400.0 38300.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G21 compound treatment 4688760.0 283742.07650273 0.313736549746989 0.5547 0.7914 1030173 HSCI1_000284 NC(=N)NO 5527320.0 572000.0 0.63 4796640.0 20500.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G22 compound treatment 730720.0 -3674297.92349727 -4.0627092304002 -7.3942 -0.9994 3176283 HSCI1_000285 COc1cc(ccc1[n+]2nc(nn2c3ccc(cc3)[N+](=O)[O-])c4ccccc4)c5ccc(c(OC)c5)[n+]6nc(nn6c7ccc(cc7)[N+](=O)[O-])c8ccccc8 995760.0 -3960000.0 -4.34 383520.0 -4390000.0 -4.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G23 compound treatment 4780480.0 375462.07650273 0.415152302734604 0.1209 0.2512 469 HSCI1_000286 CCCC(=O)O 4987240.0 31900.0 0.03 4536160.0 -240000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 G24 mock treatment 4347720.0 -57297.9234972699 -0.0633549068480417 -0.3376 -0.4046 5198880.0 244000.0 0.27 3990720.0 -785000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H01 mock treatment 4472160.0 67142.0765027301 0.0742396886794203 -0.002 -0.0074 5084160.0 129000.0 0.14 4558040.0 -218000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H02 compound treatment 4392880.0 -12137.9234972699 -0.0134210275968348 -0.0772 -0.303 1594 HSCI1_000287 N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)O 5055200.0 99900.0 0.11 4547200.0 -229000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H03 mock treatment 4270800.0 -134217.92349727 -0.148406146706386 -0.0831 -0.2066 5198800.0 244000.0 0.27 4514760.0 -261000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H04 mock treatment 4009800.0 -395217.92349727 -0.436996547161767 0.177 0.1741 5780480.0 825000.0 0.9 4616480.0 -160000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H05 mock treatment 4335320.0 -69697.9234972699 -0.0770657151455387 0.4581 0.7349 5313160.0 358000.0 0.39 5252920.0 477000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H06 mock treatment 4537400.0 132382.07650273 0.1463762316898 0.5044 0.9345 5334880.0 380000.0 0.42 5086560.0 310000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H07 compound treatment 3827280.0 -577737.92349727 -0.638810799618151 -0.814 -0.7491 3054842 HSCI1_000288 CSc1nc(c([nH]1)c2ccnc(NC(C)c3ccccc3)c2)c4ccc(F)cc4 5048520.0 93200.0 0.1 3906040.0 -870000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H08 compound treatment 4262000.0 -143017.92349727 -0.158136397756223 0.3424 0.555 1961 HSCI1_000289 CC(C)(C)c1cc(O)c(cc1O)C(C)(C)C 5123320.0 168000.0 0.18 5341200.0 565000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H09 compound treatment 3986520.0 -418497.92349727 -0.462737484029971 -0.3314 -0.5662 572 HSCI1_000290 CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 5130280.0 175000.0 0.19 4474360.0 -302000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H10 compound treatment 5073320.0 668302.07650273 0.738948520624849 -1.8941 -0.5963 1907755 HSCI1_000291 COCc1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1 2338560.0 -2620000.0 -2.87 3626240.0 -1150000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H11 compound treatment 2735280.0 -1669737.92349727 -1.84624649807515 -2.6459 -0.9261 574 HSCI1_000292 NCCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 4354400.0 -601000.0 -0.66 2705000.0 -2070000.0 -2.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H12 compound treatment 1934080.0 -2470937.92349727 -2.73214162774891 -4.6306 -0.9998 3176284 HSCI1_000293 COc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2cc1O 2516680.0 -2440000.0 -2.67 2167720.0 -2610000.0 -2.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H13 compound treatment 4679600.0 274582.07650273 0.303608242972387 1.4381 0.8227 2195 HSCI1_000294 OS(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc5ccc(c6cc(cc(c56)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c3)ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 6441840.0 1490000.0 1.63 5333360.0 557000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H14 compound treatment 4869600.0 464582.07650273 0.513693208821131 0.9802 0.8607 1714 HSCI1_000295 CN(C)C(=N)NC(=N)N 5868080.0 913000.0 1.0 4959960.0 184000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H15 compound treatment 4896120.0 491102.07650273 0.54301664721223 1.3184 0.8778 2197 HSCI1_000296 OS(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc4ccc(cc4S(=O)(=O)O)S(=O)(=O)O)C(=O)Nc5ccc(cc5S(=O)(=O)O)S(=O)(=O)O)cc(c2)C(=O)Nc6ccc(cc6S(=O)(=O)O)S(=O)(=O)O)c(c1)S(=O)(=O)O 6181200.0 1230000.0 1.34 5172600.0 397000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H16 compound treatment 5404640.0 999622.07650273 1.1052924726512 1.6277 0.9683 3054849 HSCI1_000297 CCNC(=N)NCCC[C@H](N)C(=O)O 5975480.0 1020000.0 1.12 5370760.0 595000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H17 mock treatment 5489360.0 1084342.07650273 1.19896825321281 0.9207 0.7394 5256640.0 301000.0 0.33 4841600.0 65500.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H18 mock treatment 4851960.0 446942.07650273 0.494188478307595 0.609 0.9599 5189720.0 234000.0 0.26 5078880.0 303000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H19 mock treatment 4948680.0 543662.07650273 0.601132783028072 0.7247 0.9502 5305600.0 350000.0 0.38 5045600.0 270000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H20 mock treatment 5054200.0 649182.07650273 0.717807338798385 1.2868 0.9961 5574680.0 619000.0 0.68 5605880.0 830000.0 0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H21 compound treatment 389720.0 -4015297.92349727 -4.43975645858136 -7.9477 -0.9984 3054896 HSCI1_000298 NC(=O)c1cn(C2OC(CO)[C@H](O)[C@@H]2O)c3ncnc(N)c13 435040.0 -4520000.0 -4.95 415800.0 -4360000.0 -4.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H22 compound treatment 3895600.0 -509417.92349727 -0.563268668740328 -1.153 -0.9935 2063 HSCI1_000299 CCOC(=O)c1cnc2n(CC)ncc2c1NN=C(C)C 4327680.0 -628000.0 -0.69 4032360.0 -744000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H23 compound treatment 2205880.0 -2199137.92349727 -2.43160955555054 -2.6217 -0.919 606 HSCI1_000300 CNCCNS(=O)(=O)c1cccc2cnccc12 3981440.0 -974000.0 -1.07 3737000.0 -1040000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 H24 mock treatment 4503760.0 98742.0765027301 0.109180135631106 0.1399 0.3355 4763440.0 -192000.0 -0.21 5118160.0 342000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I01 mock treatment 4149560.0 -255457.92349727 -0.282462469124817 -0.4865 -0.9969 4674840.0 -280000.0 -0.31 4524000.0 -252000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I02 compound treatment 4430600.0 25582.0765027301 0.0282863666758739 -0.3988 -0.7394 662 HSCI1_000301 Cc1nc(c(o1)c2ccncc2)c3ccccc3 4741720.0 -214000.0 -0.23 4292640.0 -483000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I03 compound treatment 3903680.0 -501337.92349727 -0.554334529140024 -0.7536 -0.926 3054901 HSCI1_000302 Clc1cc(Cl)c(NC(=O)Nc2ccncc2)c(Cl)c1 4437960.0 -517000.0 -0.57 4592360.0 -184000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I04 compound treatment 3674640.0 -730377.92349727 -0.807586426918953 -1.6108 -0.9288 2110413 HSCI1_000303 Cc1cc(C)c(/C=C/2\C(=O)Nc3ccccc23)[nH]1 3646520.0 -1310000.0 -1.43 4228880.0 -547000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I05 mock treatment 4097120.0 -307897.92349727 -0.34044591969907 -0.1929 -0.5666 4959320.0 4020.0 0.0 4778000.0 1910.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I06 mock treatment 4618720.0 213702.07650273 0.236292597073063 0.2543 0.4467 4727280.0 -228000.0 -0.25 5228400.0 452000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I07 mock treatment 4982360.0 577342.07650273 0.638373107500628 0.6906 0.7361 5573600.0 618000.0 0.68 4657160.0 -119000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I08 mock treatment 4491880.0 86862.0765027301 0.0960442967138269 0.4123 0.8434 5364560.0 409000.0 0.45 4945360.0 169000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I09 compound treatment 4361000.0 -44017.9234972699 -0.048671073445561 0.18 0.5917 2023 HSCI1_000304 CCCCn1c(=O)n(CCCC)c2ncn(CC(=O)C)c2c1=O 5222360.0 267000.0 0.29 4843760.0 67700.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I10 compound treatment 4972480.0 567462.07650273 0.627448689276494 1.4827 0.9809 2196 HSCI1_000305 OS(=O)(=O)c1cc(c2c(NC(=O)c3ccc(NC(=O)c4ccc(NC(=O)Nc5ccc(cc5)C(=O)Nc6ccc(cc6)C(=O)Nc7ccc(c8cc(cc(c78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)cc4)cc3)ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 5899720.0 944000.0 1.03 5679280.0 903000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I11 compound treatment 2239800.0 -2165217.92349727 -2.39410386059481 -4.202 -0.9997 3054905 HSCI1_000306 Oc1ccc(cc1O)C(=O)/C(=C/c2ccc3oc(=O)[nH]c3c2)/C#N 2663400.0 -2290000.0 -2.51 2410560.0 -2370000.0 -2.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I12 compound treatment 3398640.0 -1006377.92349727 -1.11276248257292 -2.3974 -0.9708 3054907 HSCI1_000307 Cc1nc2cc3nc(cnc3cc2n1C)c4cccs4 3251040.0 -1700000.0 -1.87 3607000.0 -1170000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I13 compound treatment 4693400.0 288382.07650273 0.318867045755085 0.5575 0.9071 3479224 HSCI1_000308 CC(=N)NCCCCC(N)C(=O)O 5417640.0 462000.0 0.51 4916080.0 140000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I14 compound treatment 2972240.0 -1432777.92349727 -1.58423737435136 -2.6759 -0.9986 2061 HSCI1_000309 Oc1cc(c2cc(ccc2c1N=Nc3ccc4ccccc4c3O)[N+](=O)[O-])S(=O)(=O)O 3648560.0 -1310000.0 -1.43 3162360.0 -1610000.0 -1.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I15 compound treatment 4247200.0 -157817.92349727 -0.174500910885493 0.4884 0.6411 2087 HSCI1_000310 NC(CCC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(=O)O 5310600.0 355000.0 0.39 5405200.0 629000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I16 compound treatment 4300680.0 -104337.92349727 -0.115367521550805 0.0606 0.1681 1870 HSCI1_000311 NC(=N)SCCc1cccc(CCSC(=N)N)c1 5252040.0 297000.0 0.32 4671800.0 -104000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I17 compound treatment 4486400.0 81382.0765027301 0.0899850040146105 0.0942 0.2078 2408 HSCI1_000312 NCCC(O)(P(=O)(O)O)P(=O)(O)O 5273560.0 318000.0 0.35 4501680.0 -274000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I18 compound treatment 4412400.0 7382.07650273014 0.00816243836825727 0.2038 0.5533 3054955 HSCI1_000313 Cc1ccc(cc1)S(=O)(=O)N[C@H](CCCCN)C(=O)CCl 5290920.0 336000.0 0.37 4753440.0 -22700.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I19 mock treatment 4407000.0 1982.07650273014 0.00219160249676663 0.1687 0.7716 5038760.0 83500.0 0.09 4974000.0 198000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I20 mock treatment 4542360.0 137342.07650273 0.151860555008799 0.0427 0.0976 4657280.0 -298000.0 -0.33 5023640.0 248000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I21 mock treatment 4765120.0 360102.07650273 0.398168591811253 0.1069 0.2355 4959520.0 4220.0 0.0 4559200.0 -217000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I22 mock treatment 4395600.0 -9417.92349726986 -0.010413495454158 0.1461 0.7812 5083680.0 128000.0 0.14 4898440.0 122000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I23 compound treatment 4446360.0 41342.0765027301 0.045712361737854 0.1137 0.886 1956 HSCI1_000314 N[C@H](CSCCB(O)O)C(=O)O 5059400.0 104000.0 0.11 4813200.0 37100.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 I24 mock treatment 4318600.0 -86417.9234972699 -0.0955531921402283 -0.7261 -0.8577 4540760.0 -415000.0 -0.45 4070520.0 -706000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J01 mock treatment 4258920.0 -146097.92349727 -0.161541985623666 -0.4399 -0.6197 5033400.0 78100.0 0.09 4092680.0 -683000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J02 compound treatment 2407320.0 -1997697.92349727 -2.20887526333701 -4.2564 -0.9956 1005830 HSCI1_000315 Cc1cc(ccc1N=Nc2cc(c3ccccc3c2N)S(=O)(=O)O)c4ccc(N=Nc5cc(c6ccccc6c5N)S(=O)(=O)O)c(C)c4 2430640.0 -2520000.0 -2.76 2386040.0 -2390000.0 -2.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J03 compound treatment 3186640.0 -1218377.92349727 -1.34717307604625 -1.8338 -0.9811 573 HSCI1_000316 CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26 4071160.0 -884000.0 -0.97 3918320.0 -858000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J04 compound treatment 1236960.0 -3168057.92349727 -3.50295442455142 -6.3895 -0.9992 1038990 HSCI1_000317 FC(F)(F)c1ccc2Sc3ccccc3N(CCCN4CCN(CCCl)CC4)c2c1 1417640.0 -3540000.0 -3.87 1099440.0 -3680000.0 -3.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J05 mock treatment 4444200.0 39182.0765027301 0.0433240273892577 0.3918 0.7667 5090600.0 135000.0 0.15 5261520.0 485000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J06 mock treatment 4697200.0 292182.07650273 0.32306874507206 0.504 0.8321 5421800.0 467000.0 0.51 4814960.0 38900.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J07 mock treatment 4688520.0 283502.07650273 0.313471179263812 0.5407 0.9652 5334400.0 379000.0 0.42 4983320.0 207000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J08 mock treatment 4505520.0 100502.07650273 0.111126185841074 0.2881 0.7924 4996000.0 40700.0 0.04 5118240.0 342000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J09 compound treatment 2574040.0 -1830977.92349727 -2.02453123435647 -3.2224 -0.998 3054961 HSCI1_000318 OCc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1CO 3342120.0 -1610000.0 -1.77 2992240.0 -1780000.0 -1.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J10 compound treatment 2544480.0 -1860537.92349727 -2.05721603220115 -3.9315 -0.821 1979 HSCI1_000319 Clc1ccc(cc1)C(c2ccc(Cl)cc2)[n+]3ccn(CC(OCc4ccc(Cl)cc4Cl)c5ccc(Cl)cc5Cl)c3 4543120.0 -412000.0 -0.45 490520.0 -4290000.0 -4.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J11 compound treatment 3899840.0 -505177.92349727 -0.558580456870862 -1.2766 -0.6724 580 HSCI1_000320 Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCN)c4ccccc34)c5ccccc15 5097200.0 142000.0 0.16 2974560.0 -1800000.0 -1.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J12 compound treatment 4830560.0 425542.07650273 0.470526276890947 1.2667 0.9456 3054964 HSCI1_000321 CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CCC[C@]2(C)C3C(=O)C[C@@](C)(O[C@]13C)C=C 5933480.0 978000.0 1.07 5426000.0 650000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J13 compound treatment 4436920.0 31902.0765027301 0.0352744560662111 0.0263 0.4073 907101 HSCI1_000322 NCCCCNS(=O)(=O)c1ccc2c(Cl)cccc2c1 4994520.0 39200.0 0.04 4743480.0 -32600.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J14 compound treatment 4920760.0 515742.07650273 0.570261350151772 0.6703 0.9332 3176334 HSCI1_000323 CC(C)[C@@]1(C)[C@@H]([C@H](OO)c2ccc[nH]2)[C@]3(O)[C@]4(O)[C@@]1(C)[C@@]5(O)C[C@@]3(C)[C@@]6(O)CCC(=C)[C@@H](O)[C@]46O5 5142640.0 187000.0 0.21 5160320.0 384000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J15 compound treatment 2061720.0 -2343297.92349727 -2.59100875911241 -3.9979 -0.9952 3054966 HSCI1_000324 C[C@@H]1CNCCCN1S(=O)(=O)c2cccc3cncc(C)c23 2855280.0 -2100000.0 -2.3 2749480.0 -2030000.0 -2.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J16 compound treatment 4343280.0 -61737.9234972699 -0.0682642607868229 0.4394 0.6954 3176335 HSCI1_000325 CN1CCN(CCCC(=O)O[C@H]2[C@@H](O)[C@H]3C(C)(C)CC[C@H](O)[C@]3(C)[C@@]4(O)C(=O)C[C@@](C)(O[C@]24C)C=C)CC1 5188480.0 233000.0 0.26 5348040.0 572000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J17 compound treatment 1903680.0 -2501337.92349727 -2.7657552222847 -4.5473 -0.9993 1049343 HSCI1_000326 CCC(C)C1NC(=O)C(NC(=O)c2c(N)c(=O)c(C)c3oc4c(C)ccc(C(=O)NC5C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C6CCCN6C(=O)C(NC5=O)C(C)C)c4nc23)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCN7C1=O 2623280.0 -2330000.0 -2.55 2228680.0 -2550000.0 -2.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J18 compound treatment 4594840.0 189822.07650273 0.209888233996915 0.2138 0.8381 3054969 HSCI1_000327 C[C@@]12CCC(=O)C=C2CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@@]4(O)C[C@H](O)[C@@H]31 4970200.0 14900.0 0.02 4919760.0 144000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J19 mock treatment 3747040.0 -657977.92349727 -0.727532997827115 0.0778 0.078 5152720.0 197000.0 0.22 5419840.0 644000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J20 mock treatment 4540440.0 135422.07650273 0.14973759114338 0.2184 0.989 5049960.0 94700.0 0.1 4900520.0 124000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J21 mock treatment 4722280.0 317262.07650273 0.350799960564094 0.1524 0.4042 4995760.0 40500.0 0.04 4645480.0 -131000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J22 mock treatment 4607480.0 202462.07650273 0.223864412777589 0.3046 0.7842 4943040.0 -12300.0 -0.01 5092080.0 316000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J23 compound treatment 2910640.0 -1494377.92349727 -1.65234913170022 -2.5654 -0.9943 3054970 HSCI1_000328 NC(=NCCSSCCN=C(N)N)N 3796800.0 -1160000.0 -1.27 3259200.0 -1520000.0 -1.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 J24 mock treatment 4175920.0 -229097.92349727 -0.25331594438917 -0.7476 -0.9506 4409160.0 -546000.0 -0.6 4334200.0 -442000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K01 mock treatment 4208240.0 -196777.92349727 -0.217579385987952 -0.4755 -0.9783 4631800.0 -323000.0 -0.35 4525320.0 -251000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K02 compound treatment 2485640.0 -1919377.92349727 -2.12227602899347 -4.2304 -0.9882 637 HSCI1_000329 C/C(=C(\C#N)/C(=O)Nc1ccc(OC(F)(F)F)cc1)/O 2918240.0 -2040000.0 -2.23 1812600.0 -2960000.0 -2.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K03 compound treatment 3681680.0 -723337.92349727 -0.799802226079083 -1.3803 -0.9968 391 HSCI1_000330 Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1 4157480.0 -798000.0 -0.87 4061400.0 -715000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K04 compound treatment 90160.0 -4314857.92349727 -4.77098305000058 -8.5164 -0.9985 3055003 HSCI1_000331 O=C1c2ccccc2-[n+]3ccc4c5ccccc5[nH]c4c13 119560.0 -4840000.0 -5.3 108680.0 -4670000.0 -4.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K05 compound treatment 693520.0 -3711497.92349727 -4.10384165529269 -6.7648 -0.9988 3055004 HSCI1_000332 Fc1ccc(cc1)C(=O)/C=C/2\C(=O)Nc3ccc(Br)cc23 1338640.0 -3620000.0 -3.96 1136720.0 -3640000.0 -3.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K06 compound treatment 138720.0 -4266297.92349727 -4.71728975557102 -8.4407 -0.9983 3176336 HSCI1_000333 CC(C)(C)C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c3ccccc32 136600.0 -4820000.0 -5.28 167120.0 -4610000.0 -4.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K07 mock treatment 3960560.0 -444457.92349727 -0.491441724626989 0.0445 0.07 5243840.0 289000.0 0.32 5027800.0 252000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K08 mock treatment 4540040.0 135022.07650273 0.149295307004751 0.545 0.7234 5627400.0 672000.0 0.74 4834440.0 58300.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K09 mock treatment 4597040.0 192022.07650273 0.212320796759374 0.4044 0.8471 5341080.0 386000.0 0.42 4841440.0 65300.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K10 mock treatment 4945880.0 540862.07650273 0.59803679405767 1.0947 0.9814 5412280.0 457000.0 0.5 5570840.0 795000.0 0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K11 compound treatment 1755120.0 -2649897.92349727 -2.93001955137149 -5.0052 -0.9989 3055006 HSCI1_000334 COc1cccc(c1)c2cc(NCc3ccc4OCOc4c3)nc(N)n2 2187640.0 -2770000.0 -3.03 2077400.0 -2700000.0 -2.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K12 compound treatment 4204400.0 -200617.92349727 -0.22182531371879 0.2146 0.4501 3176337 HSCI1_000335 COc1ccc(cc1)c2cnc3c(cnn3c2)c4ccsc4 5254960.0 300000.0 0.33 5040520.0 264000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K13 compound treatment 3269480.0 -1135537.92349727 -1.2555760309362 -1.7821 -0.8816 3055009 HSCI1_000336 CC1=C(O)C(=O)[C@H]2O[C@H]2C1=O 4708520.0 -247000.0 -0.27 3220800.0 -1560000.0 -1.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K14 compound treatment 5295960.0 890942.07650273 0.985123872185714 1.1707 0.9388 1709 HSCI1_000337 NCCCC(O)(P(=O)(O)O)P(=O)(O)O 5562200.0 607000.0 0.66 5152640.0 377000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K15 mock treatment 4871960.0 466942.07650273 0.516302685239042 0.7019 0.9284 5115960.0 161000.0 0.18 5297640.0 522000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K16 mock treatment 4432600.0 27582.0765027301 0.0304977873690186 0.0961 0.747 5068920.0 114000.0 0.12 4787560.0 11500.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K17 compound treatment 3605400.0 -799617.92349727 -0.884145811315622 -2.2398 -0.9333 3176338 HSCI1_000338 CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(=O)(O)CO 4040280.0 -915000.0 -1.0 2789960.0 -1990000.0 -1.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K18 compound treatment 4512520.0 107502.07650273 0.11886615826708 -0.1884 -0.4274 1932 HSCI1_000339 OP(=O)(O)Oc1cccc2ccccc12 4568120.0 -387000.0 -0.42 4754960.0 -21100.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K19 compound treatment 4545120.0 140102.07650273 0.154912315565338 -1.1026 -0.5096 95 HSCI1_000340 CCCCCC(O)/C=C/C=O 2986200.0 -1970000.0 -2.16 4867440.0 91300.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K20 compound treatment 4352040.0 -52977.9234972699 -0.0585782381508492 0.0588 0.2858 3176339 HSCI1_000341 CC(C)[C@@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@@H](O)C[C@H](O)C3=C)\CCC[C@]12C 4924360.0 -30900.0 -0.03 4969680.0 194000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K21 mock treatment 4645560.0 240542.07650273 0.265969862775064 -0.0351 -0.089 4920080.0 -35200.0 -0.04 4489000.0 -287000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K22 mock treatment 4251520.0 -153497.92349727 -0.169724242188301 -0.5328 -0.9457 4657080.0 -298000.0 -0.33 4351120.0 -425000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K23 mock treatment 4526720.0 121702.07650273 0.134567245188407 0.0614 0.3479 4869880.0 -85400.0 -0.09 4841120.0 65000.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 K24 mock treatment 4360440.0 -44577.9234972699 -0.0492902712396415 -0.7764 -0.8455 4337920.0 -617000.0 -0.68 4158960.0 -617000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L01 mock treatment 4321560.0 -83457.9234972699 -0.0922802895143741 -0.2998 -0.8682 4670040.0 -285000.0 -0.31 4661920.0 -114000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L02 compound treatment 3927800.0 -477217.92349727 -0.527664795580699 -0.5742 -0.7631 594 HSCI1_000342 Cc1nc2sccn2c(=O)c1CCN3CCC(=C(c4ccccc4)c5ccc(F)cc5)CC3 4469120.0 -486000.0 -0.53 4841360.0 65300.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L03 compound treatment 144680.0 -4260337.92349727 -4.71069972190545 -8.381 -0.9986 581 HSCI1_000343 Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16 214440.0 -4740000.0 -5.19 178800.0 -4600000.0 -4.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L04 compound treatment 840040.0 -3564977.92349727 -3.94183297531291 -6.2274 -0.997 1002019 HSCI1_000344 COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O 1679320.0 -3280000.0 -3.59 1530880.0 -3250000.0 -3.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L05 compound treatment 2061520.0 -2343497.92349727 -2.59122990118173 -4.919 -0.9961 3055016 HSCI1_000345 COc1cc2ncnc(N3CCN(CC3)C(=O)Nc4ccc(Oc5ccccc5)cc4)c2cc1OC 2045840.0 -2910000.0 -3.19 2043280.0 -2730000.0 -2.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L06 compound treatment 4282040.0 -122977.92349727 -0.135977962410913 -0.1479 -0.3735 2348 HSCI1_000346 COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)CCC5=O 4666640.0 -289000.0 -0.32 4971320.0 195000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L07 mock treatment 4472680.0 67662.0765027301 0.074814658059638 0.2855 0.73 4989680.0 34400.0 0.04 5156680.0 381000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L08 mock treatment 4628520.0 223502.07650273 0.247128558469471 0.5632 0.9394 5170400.0 215000.0 0.24 5267200.0 491000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L09 mock treatment 4613800.0 208782.07650273 0.230852502167927 0.7624 0.8346 5173160.0 218000.0 0.24 5624160.0 848000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L10 mock treatment 4768200.0 363182.07650273 0.401574179678696 1.0349 0.8066 5125800.0 171000.0 0.19 5976000.0 1200000.0 1.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L11 compound treatment 2280960.0 -2124057.92349727 -2.34859282272989 -4.99 -0.9858 582 HSCI1_000347 CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26 2434440.0 -2520000.0 -2.76 1254960.0 -3520000.0 -3.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L12 compound treatment 5188240.0 783222.07650273 0.866016753652942 1.2529 0.9377 595 HSCI1_000348 Fc1ccc(cc1)C(=C2CCN(CCn3c(=O)c4ccccc4[nH]c3=S)CC2)c5ccc(F)cc5 5272880.0 318000.0 0.35 5728960.0 953000.0 0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L13 compound treatment 4913360.0 508342.07650273 0.562079093587137 0.0542 0.0797 3176385 HSCI1_000349 NCC1OC(OC2C(N)CC(N)C(O)C2O[C@@H]3OC[C@H](COCC4OCC(O)C(O)C4N)[C@@H]3O)C(N)C(O)C1O 4618960.0 -336000.0 -0.37 4676520.0 -99600.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L14 compound treatment 4630480.0 225462.07650273 0.249295750748753 0.2374 0.7604 3055065 HSCI1_000350 Nc1ncn([C@@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 4932960.0 -22300.0 -0.02 4961760.0 186000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L15 mock treatment 4647880.0 242862.07650273 0.268535110779112 0.7299 0.9473 5305920.0 351000.0 0.38 5385600.0 610000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L16 mock treatment 4532520.0 127502.07650273 0.140980365198527 0.504 0.9392 5298120.0 343000.0 0.38 5131360.0 355000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L17 compound treatment 3617400.0 -787617.92349727 -0.870877287156753 -0.8924 -0.864 372 HSCI1_000351 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC 4830600.0 -125000.0 -0.14 4239680.0 -536000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L18 compound treatment 4507280.0 102262.07650273 0.113072236051041 0.0052 0.0383 1367 HSCI1_000352 Cc1cc(O)ccc1Cl 4915800.0 -39500.0 -0.04 4715480.0 -60600.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L19 compound treatment 1160000.0 -3245017.92349727 -3.58804989282362 -4.5307 -0.9002 3055069 HSCI1_000353 CC/C(=C(\c1ccc(O)cc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 4198840.0 -756000.0 -0.83 1357440.0 -3420000.0 -3.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L20 compound treatment 4776920.0 371902.07650273 0.411215973900807 0.5727 0.8233 2237 HSCI1_000354 FS(=O)(=O)Cc1ccccc1 4973600.0 18300.0 0.02 5334840.0 559000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L21 mock treatment 4644360.0 239342.07650273 0.264643010359177 0.2292 0.4888 4773200.0 -182000.0 -0.2 5106640.0 331000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L22 mock treatment 4693080.0 288062.07650273 0.318513218444182 -0.1006 -0.213 4721600.0 -234000.0 -0.26 4540160.0 -236000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L23 mock treatment 4892160.0 487142.07650273 0.538638034239803 0.192 0.2094 4391400.0 -564000.0 -0.62 5186160.0 410000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 L24 mock treatment 4208480.0 -196537.92349727 -0.217314015504774 -0.6393 -0.9471 4620600.0 -335000.0 -0.37 4254440.0 -522000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M01 mock treatment 4270560.0 -134457.92349727 -0.148671517189564 -0.2717 -0.5119 4514040.0 -441000.0 -0.48 4936840.0 161000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M02 compound treatment 4534280.0 129262.07650273 0.142926415408494 -0.3722 -0.6474 1900 HSCI1_000355 COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1 4597440.0 -358000.0 -0.39 4381720.0 -394000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M03 compound treatment 2319840.0 -2085177.92349727 -2.30560280445516 -4.1606 -0.9951 3055072 HSCI1_000356 Cn1cc(/C=C/2\C(=O)Nc3ccc(cc23)S(=O)(=O)N)c4ccccc14 2463280.0 -2490000.0 -2.73 2612160.0 -2160000.0 -2.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M04 compound treatment 1077240.0 -3327777.92349727 -3.67955848110595 -6.4504 -0.9987 292 HSCI1_000357 O=C1NCc2c1c3c4ccccc4[nH]c3c5[nH]c6ccccc6c25 1326560.0 -3630000.0 -3.97 1269600.0 -3510000.0 -3.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M05 compound treatment 2604320.0 -1800697.92349727 -1.99105032506226 -3.9686 -0.9931 907290 HSCI1_000358 CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](O)[C@@]3(C)O[C@](C)(CC(=O)[C@@]32O)C=C 2539160.0 -2420000.0 -2.65 2547280.0 -2230000.0 -2.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M06 compound treatment 5260880.0 855862.07650273 0.946335553227957 0.346 0.3422 3055076 HSCI1_000359 NS(=O)(=O)c1ccc(N/C=C/2\C(=O)Nc3ccccc23)cc1 4630000.0 -325000.0 -0.36 4785280.0 9190.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M07 compound treatment 4742280.0 337262.07650273 0.372914167495541 -0.6854 -0.4358 3055122 HSCI1_000360 OC(=O)c1ccc2c3nc4ccccc4n3c(=O)c5cccc1c52 3560280.0 -1400000.0 -1.53 4743840.0 -32300.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M08 compound treatment 2051240.0 -2353777.92349727 -2.60259660354449 -4.6995 -0.9935 3176387 HSCI1_000361 Nc1cccc(c1)c2cc3c(Oc4cccc(O)c4)ncnc3[nH]2 2089480.0 -2870000.0 -3.14 2385840.0 -2390000.0 -2.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M09 mock treatment 4990960.0 585942.07650273 0.647882216481151 0.4108 0.6325 4977920.0 22600.0 0.02 4814880.0 38800.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M10 mock treatment 4703520.0 298502.07650273 0.330056834462397 0.9843 0.6706 4905720.0 -49600.0 -0.05 6200080.0 1420000.0 1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M11 mock treatment 5303640.0 898622.07650273 0.99361572764739 0.9625 0.7446 4826360.0 -129000.0 -0.14 5587800.0 812000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M12 mock treatment 5072520.0 667502.07650273 0.738063952347591 0.9991 0.7688 4887200.0 -68100.0 -0.07 5839280.0 1060000.0 1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M13 mock treatment 5327440.0 922422.07650273 1.01993163389581 0.7362 0.6145 4683000.0 -272000.0 -0.3 5327440.0 551000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M14 mock treatment 5077040.0 672022.07650273 0.743061763114098 0.8758 0.879 5065960.0 111000.0 0.12 5426400.0 650000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M15 compound treatment 4704880.0 299862.07650273 0.331560600533735 0.3663 0.8008 2796 HSCI1_000362 CCCCCCCC/C=C\CCCCCCCC(=O)O 4944320.0 -11000.0 -0.01 5089800.0 314000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M16 compound treatment 1797160.0 -2607857.92349727 -2.88353548840159 -5.3203 -0.9967 3176388 HSCI1_000363 COC(=O)CC(O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@@H]2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC 1829840.0 -3130000.0 -3.42 1877680.0 -2900000.0 -2.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M17 compound treatment 2875920.0 -1529097.92349727 -1.69073939493321 -3.6223 -0.8716 1000076 HSCI1_000364 CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OCC[N+](C)(C)C)OC 1585920.0 -3370000.0 -3.69 3885840.0 -890000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M18 compound treatment 3350520.0 -1054497.92349727 -1.16596926444998 -2.7875 -0.9354 2058 HSCI1_000365 OC(=O)C1C(C2CCC1O2)C(=O)O 2700480.0 -2250000.0 -2.47 3587560.0 -1190000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M19 compound treatment 4557440.0 152422.07650273 0.16853466703511 0.1046 0.32 1000072 HSCI1_000366 CC(C)OP(=O)(F)OC(C)C 4780240.0 -175000.0 -0.19 4979760.0 204000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M20 compound treatment 296560.0 -4108457.92349727 -4.54276443446804 -8.0249 -0.9993 3176389 HSCI1_000367 CC(=O)O[C@@H]1CC2[C@@]3(C)CCCC(C)(C)C3CC[C@@]2(C)C4CC=C(C=O)[C@H](C=O)[C@@]14C 508800.0 -4450000.0 -4.87 304680.0 -4470000.0 -4.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M21 compound treatment 4430760.0 25742.0765027301 0.0284632803313254 -0.3358 -0.4956 3176390 HSCI1_000368 CCCC(=O)OC1C(OC2COP(O)(O)OC12)n3cnc4c(=O)[nH]c(NOC(=C)CC)nc34 4339960.0 -615000.0 -0.67 4839680.0 63600.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M22 compound treatment 4146400.0 -258617.92349727 -0.285956513819985 -1.6113 -0.8979 3055129 HSCI1_000369 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@@]21C)c5ccc(cc5)N(C)C 3790720.0 -1160000.0 -1.28 3550880.0 -1230000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M23 mock treatment 4611720.0 206702.07650273 0.228552624647056 0.0117 0.0199 4523160.0 -432000.0 -0.47 5040120.0 264000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 M24 mock treatment 4446520.0 41502.0765027301 0.0458892753933055 -0.4267 -0.6082 4321320.0 -634000.0 -0.69 4685680.0 -90400.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N01 mock treatment 4546800.0 141782.07650273 0.15676990894758 0.1335 0.1875 4542120.0 -413000.0 -0.45 5301080.0 525000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N02 compound treatment 1915880.0 -2489137.92349727 -2.75226555605652 -4.6435 -0.9939 600 HSCI1_000370 COC(=O)/C=C/c1cc(O)ccc1O 2213080.0 -2740000.0 -3.0 2496800.0 -2280000.0 -2.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N03 compound treatment 1708120.0 -2696897.92349727 -2.98198793766039 -5.3035 -0.9969 630 HSCI1_000371 COc1ccc(cc1)S(=O)(=O)N(CCO)c2ccccc2CN(C)C/C=C/c3ccc(Cl)cc3 1857920.0 -3100000.0 -3.39 1974160.0 -2800000.0 -2.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N04 compound treatment 3687560.0 -717457.92349727 -0.793300649241238 -1.551 -0.9964 2283 HSCI1_000372 CCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 4118400.0 -837000.0 -0.92 3803000.0 -973000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N05 compound treatment 3614160.0 -790857.92349727 -0.874459788679648 -2.8472 -0.9494 629 HSCI1_000373 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2CN(C)C/C=C/c3ccc(Cl)cc3 3106560.0 -1850000.0 -2.02 2750960.0 -2030000.0 -2.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N06 compound treatment 5033360.0 628342.07650273 0.694764335175818 0.7818 0.6824 1884 HSCI1_000374 Cc1ccnc(N)c1 4751000.0 -204000.0 -0.22 5656000.0 880000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N07 compound treatment 992480.0 -3412537.92349727 -3.77327849008142 -7.5896 -0.9944 1918023 HSCI1_000375 CC[n+]1c(/C=C/N(C)c2ccccc2)n(c3ccccc3)c4ccc(cc14)c5nc6ccccc6s5 480280.0 -4480000.0 -4.9 320400.0 -4460000.0 -4.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N08 compound treatment 4696560.0 291542.07650273 0.322361090450254 -0.1525 -0.2893 2344 HSCI1_000376 FC(F)(F)C(=O)CC(=O)c1cccs1 4715680.0 -240000.0 -0.26 4453160.0 -323000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N09 mock treatment 4844680.0 439662.07650273 0.486138906984549 1.7836 0.9111 5849560.0 894000.0 0.98 6394040.0 1620000.0 1.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N10 mock treatment 4890160.0 485142.07650273 0.536426613546659 0.7402 0.8079 4958000.0 2700.0 0.0 5516160.0 740000.0 0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N11 mock treatment 4974160.0 569142.07650273 0.629306282658735 0.5779 0.6814 4799400.0 -156000.0 -0.17 5316560.0 540000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N12 mock treatment 5113280.0 708262.07650273 0.783132706073879 1.5011 0.7531 4940600.0 -14700.0 -0.02 6602560.0 1830000.0 1.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N13 mock treatment 5221080.0 816062.07650273 0.902328281434378 1.134 0.9316 5231920.0 277000.0 0.3 5532200.0 756000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N14 mock treatment 4890360.0 485342.07650273 0.536647755615973 0.5918 0.5734 4654520.0 -301000.0 -0.33 5590880.0 815000.0 0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N15 compound treatment 1639160.0 -2765857.92349727 -3.05823772316002 -4.7525 -0.9871 1000048 HSCI1_000377 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 3024400.0 -1930000.0 -2.11 1728160.0 -3050000.0 -3.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N16 compound treatment 5136480.0 731462.07650273 0.808785186114358 0.8018 0.8734 2187 HSCI1_000378 O=C(NC1CCCCC1)NC2CCCCC2 5127880.0 173000.0 0.19 5165600.0 390000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N17 compound treatment 4783880.0 378862.07650273 0.41891171791295 0.7003 0.7788 2083 HSCI1_000379 CC(CCC(=O)NCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C 4953880.0 -1420.0 0.0 5568920.0 793000.0 0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N18 compound treatment 4957680.0 552662.07650273 0.611084176147223 0.6488 0.7192 1934 HSCI1_000380 NNC(=N)N 4830480.0 -125000.0 -0.14 5423080.0 647000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N19 compound treatment 5166840.0 761822.07650273 0.842354552236294 0.9496 0.8846 30 HSCI1_000381 COC(=O)C1=C(C)NC(=C(C1c2ccccc2C(F)(F)F)[N+](=O)[O-])C 5097040.0 142000.0 0.16 5421000.0 645000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N20 compound treatment 213960.0 -4191057.92349727 -4.63409610909492 -8.2891 -0.9985 420 HSCI1_000382 CCN1C(=O)C=CC1=O 248240.0 -4710000.0 -5.15 224040.0 -4550000.0 -4.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N21 compound treatment 2950960.0 -1454057.92349727 -1.60776689052642 -1.8298 -0.8879 3054850 HSCI1_000383 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 3812800.0 -1140000.0 -1.25 4466880.0 -309000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N22 compound treatment 2033280.0 -2371737.92349727 -2.62245516136893 -4.6701 -0.9975 2003 HSCI1_000384 CNC1CCc2cc(OC)c(OC)c(OC)c2-c3ccc(OC)c(=O)cc13 2252640.0 -2700000.0 -2.96 2278360.0 -2500000.0 -2.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N23 mock treatment 4230040.0 -174977.92349727 -0.193474900432675 0.0381 0.1257 4981080.0 25800.0 0.03 5006440.0 230000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 N24 mock treatment 4276960.0 -128057.92349727 -0.141594970971501 -0.737 -0.6854 3984160.0 -971000.0 -1.06 4704960.0 -71100.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O01 mock treatment 4422080.0 17062.0765027301 0.0188657145230775 -0.7182 -0.6022 3868360.0 -1090000.0 -1.19 4703880.0 -72200.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O02 mock treatment 4675880.0 270862.07650273 0.299495000483138 0.0588 0.0909 4505920.0 -449000.0 -0.49 5069480.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O03 compound treatment 2697800.0 -1707217.92349727 -1.88768852186468 -3.6215 -0.9843 3054852 HSCI1_000385 O=C/1Nc2ccc(cc2\C1=C\c3ccc[nH]3)c4cccnc4 2565720.0 -2390000.0 -2.62 3014280.0 -1760000.0 -1.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O04 compound treatment 1431280.0 -2973737.92349727 -3.28809279000548 -5.0683 -0.9939 3176393 HSCI1_000386 Cn1nc(N)c2cn(C3OC(CO)C(O)C3O)c4ncnc1c24 2227280.0 -2730000.0 -2.99 2282120.0 -2490000.0 -2.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O05 compound treatment 1146120.0 -3258897.92349727 -3.60339715243405 -6.461 -0.997 3176394 HSCI1_000387 C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5[nH]cnc25 1181400.0 -3770000.0 -4.13 1333920.0 -3440000.0 -3.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O06 compound treatment 3307040.0 -1097977.92349727 -1.21404555031894 -2.5545 -0.9639 575 HSCI1_000388 O=C1NC(=O)C(=C1c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 3083240.0 -1870000.0 -2.05 3619880.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O07 compound treatment 2432160.0 -1972857.92349727 -2.18140941832815 -4.0654 -0.9873 3176395 HSCI1_000389 CCCCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@@H](N2C1=O)c5ccc(OC)cc5 2335240.0 -2620000.0 -2.87 2792400.0 -1980000.0 -1.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O08 compound treatment 3444880.0 -960137.92349727 -1.06163443614741 -1.7668 -0.9823 2116778 HSCI1_000390 CCOC(=O)c1cnc2oc3ccc(O)cc3c2c1c4ccccc4 3827600.0 -1130000.0 -1.23 4015200.0 -761000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O09 compound treatment 1694000.0 -2711017.92349727 -2.99760056775399 -5.6177 -0.9964 3176396 HSCI1_000391 CC(C)[C@H](CO)Nc1nc(Nc2cc(N)cc(Cl)c2)c3ncn(C(C)C)c3n1 1639560.0 -3320000.0 -3.63 1685720.0 -3090000.0 -3.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O10 compound treatment 2560800.0 -1844217.92349727 -2.03917083934509 -4.0023 -0.9844 676 HSCI1_000392 COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC 2313160.0 -2640000.0 -2.89 2783600.0 -1990000.0 -2.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O11 mock treatment 4802800.0 397782.07650273 0.439831757670099 1.0296 0.9448 5373120.0 418000.0 0.46 5658800.0 883000.0 0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O12 mock treatment 4784720.0 379702.07650273 0.419840514604071 0.9308 0.9631 5359720.0 404000.0 0.44 5522960.0 747000.0 0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O13 mock treatment 4799720.0 394702.07650273 0.436426169802656 0.7324 0.7427 4909000.0 -46300.0 -0.05 5655800.0 880000.0 0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O14 mock treatment 5238160.0 833142.07650273 0.921213814153833 0.9813 0.7944 4915680.0 -39600.0 -0.04 5594920.0 819000.0 0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O15 compound treatment 4716280.0 311262.07650273 0.34416569848466 0.5054 0.7675 1398 HSCI1_000393 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OC(=O)C)c(C)c(C)c2O1 4928400.0 -26900.0 -0.03 5334760.0 559000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O16 compound treatment 4566000.0 160982.07650273 0.177999547601769 -0.5859 -0.6215 2060355 HSCI1_000394 CC1=C(C=C)/C(=C/c2[nH]c(Cc3[nH]c(\C=C\4/NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)/NC1=O 4164360.0 -791000.0 -0.87 4450680.0 -325000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O17 compound treatment 5120960.0 715942.07650273 0.791624561535555 0.5816 0.5575 1929 HSCI1_000395 Nc1cccc2c(=O)[nH]ccc12 4626360.0 -329000.0 -0.36 5350000.0 574000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O18 compound treatment 4797360.0 392342.07650273 0.433816693384745 0.6235 0.8474 2286 HSCI1_000396 CCSC(=N)N 5004840.0 49500.0 0.05 5365760.0 590000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O19 compound treatment 4645600.0 240582.07650273 0.266014091188927 0.4035 0.7096 23 HSCI1_000397 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O 4895560.0 -59700.0 -0.07 5272560.0 496000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O20 compound treatment 503720.0 -3901297.92349727 -4.31370547907212 -6.8197 -0.9917 3054913 HSCI1_000398 Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc2ccccc2)C(=O)CCl 2020680.0 -2930000.0 -3.21 506800.0 -4270000.0 -4.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O21 compound treatment 4654480.0 249462.07650273 0.275832799066489 -0.6023 -0.6126 3176397 HSCI1_000399 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(=C/C=C/3\C[C@@H](O)C[C@H](O)C3=C)/CCC[C@@]12C 4445480.0 -510000.0 -0.56 4018040.0 -758000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O22 compound treatment 4624280.0 219262.07650273 0.242440346600005 -0.3016 -0.2982 988 HSCI1_000400 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 4077120.0 -878000.0 -0.96 4972320.0 196000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O23 mock treatment 4660440.0 255422.07650273 0.282422832732061 -0.3639 -0.3056 3918760.0 -1040000.0 -1.14 4997680.0 222000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 O24 mock treatment 3415440.0 -989577.92349727 -1.0941865487505 -1.0508 -0.766 4204960.0 -750000.0 -0.82 4871640.0 95500.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P01 mock treatment 4048360.0 -356657.92349727 -0.394360356197938 -1.2763 -0.9131 3876920.0 -1080000.0 -1.18 4143000.0 -633000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P02 mock treatment 4545680.0 140662.07650273 0.155531513359419 -0.3312 -0.3451 4109480.0 -846000.0 -0.93 4972440.0 196000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P03 mock treatment 4857720.0 452702.07650273 0.500557369903852 -0.21 -0.235 4291000.0 -664000.0 -0.73 4639800.0 -136000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P04 mock treatment 5068720.0 663702.07650273 0.733862253030616 -0.1082 -0.082 3964320.0 -991000.0 -1.09 4939400.0 163000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P05 mock treatment 4877760.0 472742.07650273 0.522715805249162 -0.5706 -0.3436 3517280.0 -1440000.0 -1.57 4839720.0 63600.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P06 mock treatment 5268200.0 863182.07650273 0.954429352964866 0.7211 0.6554 4763040.0 -192000.0 -0.21 5279320.0 503000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P07 mock treatment 4736800.0 331782.07650273 0.366854874796325 -0.2638 -0.2631 4108400.0 -847000.0 -0.93 4879400.0 103000.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P08 mock treatment 4850520.0 445502.07650273 0.492596255408531 -0.174 -0.1758 4173440.0 -782000.0 -0.86 4838120.0 62000.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P09 mock treatment 4951560.0 546542.07650273 0.6043172288262 -0.0121 -0.0135 4347040.0 -608000.0 -0.67 4816760.0 40700.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P10 mock treatment 5025120.0 620102.07650273 0.685653281920062 0.2797 0.2628 4345680.0 -610000.0 -0.67 5240920.0 465000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P11 mock treatment 5404920.0 999902.07650273 1.10560207154824 0.8419 0.6359 4674280.0 -281000.0 -0.31 5434160.0 658000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P12 mock treatment 4979120.0 574102.07650273 0.634790605977734 0.0471 0.0381 4066600.0 -889000.0 -0.97 5194560.0 418000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P13 mock treatment 4288560.0 -116457.92349727 -0.128768730951261 -0.7625 -0.7957 4128560.0 -827000.0 -0.91 4490560.0 -286000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P14 mock treatment 4735280.0 330262.07650273 0.365174195069535 -0.2012 -0.1869 4062840.0 -892000.0 -0.98 5038920.0 263000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P15 mock treatment 4580120.0 175102.07650273 0.19361217769537 -0.1481 -0.2192 4386000.0 -569000.0 -0.62 4948840.0 173000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P16 mock treatment 4679840.0 274822.07650273 0.303873613455564 -0.2746 -0.1856 3735160.0 -1220000.0 -1.34 5330880.0 555000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P17 mock treatment 4609360.0 204342.07650273 0.225943148229145 -0.6113 -0.4594 3758200.0 -1200000.0 -1.31 4802200.0 26100.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P18 mock treatment 5075560.0 670542.07650273 0.741425311801171 0.1234 0.0993 4116680.0 -839000.0 -0.92 5165480.0 389000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P19 mock treatment 4517440.0 112422.07650273 0.124306253172216 -0.8178 -0.6195 3777320.0 -1180000.0 -1.29 4526200.0 -250000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P20 mock treatment 4332080.0 -72937.9234972699 -0.0806482166684331 -0.8136 -0.7356 3975360.0 -980000.0 -1.07 4521680.0 -254000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P21 mock treatment 4578400.0 173382.07650273 0.191710355899266 -1.4936 -0.7489 3869400.0 -1090000.0 -1.19 3192200.0 -1580000.0 -1.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P22 mock treatment 4404680.0 -337.923497269861 -3.73645507281196E-4 -0.493 -0.3119 3622040.0 -1330000.0 -1.46 5380400.0 604000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P23 mock treatment 4224600.0 -180417.92349727 -0.199489964718028 -1.3072 -0.7263 3345400.0 -1610000.0 -1.76 4475560.0 -301000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2105 P24 mock treatment 3636880.0 -768137.92349727 -0.849338049605524 -1.9858 -0.9212 3284680.0 -1670000.0 -1.83 4018160.0 -758000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A01 compound treatment 4689680.0 -1401797.41935484 -1.54998191037905 -2.5876 -0.999 3220649 PK04_107001 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 3909000.0 -1280000.0 -1.4 4376240.0 -1530000.0 -1.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A02 compound treatment 5098040.0 -993437.41935484 -1.09845403325277 -1.8612 -0.9737 3188507 PK04_107002 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(o3)c4ccc(Cl)c(Cl)c4 4498800.0 -690000.0 -0.76 4536480.0 -1360000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A03 compound treatment 5715880.0 -375597.41935484 -0.415301952726517 -0.9364 -0.9047 3220651 PK04_107003 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4cncn4C)oc(C(=O)C)c1C(=O)OC 4904680.0 -284000.0 -0.31 5008960.0 -892000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A04 compound treatment 5157320.0 -934157.41935484 -1.03290752390796 -1.2807 -0.9628 3070126 PK04_107004 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 4639040.0 -550000.0 -0.6 5319920.0 -581000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A05 compound treatment 5377680.0 -713797.41935484 -0.789253191937283 -1.1044 -0.9653 3220653 PK04_107005 CCCCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 4826720.0 -362000.0 -0.4 5176640.0 -725000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A06 compound treatment 5326000.0 -765477.41935484 -0.846396302648141 -1.1565 -0.8922 3070127 PK04_107006 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 5011040.0 -178000.0 -0.19 4942480.0 -959000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A07 compound treatment 5886600.0 -204877.41935484 -0.226535082359687 -0.154 -0.5915 3220655 PK04_107007 CCOC(=O)c1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 5251040.0 62400.0 0.07 5793240.0 -108000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A08 compound treatment 5490960.0 -600517.41935484 -0.663998323877568 -1.3378 -0.8099 3070128 PK04_107008 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3CO[Si](C(C)C)(C(C)C)c31 5053520.0 -135000.0 -0.15 4401520.0 -1500000.0 -1.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A09 compound treatment 6049520.0 -41957.4193548402 -0.0463927526961214 -0.367 -0.7904 3220657 PK04_107009 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)c3ccccn3)oc(C(=O)C)c1C(=O)OC 5048480.0 -140000.0 -0.15 5467120.0 -434000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A10 compound treatment 5551320.0 -540157.41935484 -0.597257647358461 -0.6101 -0.8902 3070129 PK04_107010 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C3CC3 5034480.0 -154000.0 -0.17 5611760.0 -290000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A11 compound treatment 6058480.0 -32997.4193548402 -0.0364855879908332 -0.0307 -0.0968 3220659 PK04_107011 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCCC3)oc(C(=O)C)c1C(=O)OC 5384280.0 196000.0 0.21 5671240.0 -230000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A12 compound treatment 5844880.0 -246597.41935484 -0.272665318018685 -0.3757 -0.8903 3188513 PK04_107012 CCCCCCc1nc(CCCc2cc3CO[Si](C(C)C)(C(C)C)c3c(CCCCCC)n2)cc4CO[Si](C(C)C)(C(C)C)c41 5132040.0 -56600.0 -0.06 5586360.0 -315000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A13 mock treatment 5627960.0 -463517.41935484 -0.512516006397157 -0.9342 -0.9991 4670720.0 -518000.0 -0.57 5364800.0 -536000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A14 mock treatment 5456840.0 -634637.41935484 -0.701725160902616 -0.9463 -0.9764 4816760.0 -372000.0 -0.41 5373160.0 -528000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A15 compound treatment 5701880.0 -389597.41935484 -0.43078189757853 -0.6057 -0.9363 3220661 PK04_107013 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 4774400.0 -414000.0 -0.45 5737240.0 -164000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A16 compound treatment 5804520.0 -286957.41935484 -0.317291787606345 -0.3521 -0.8704 3188514 PK04_107014 CCCCCCc1nc(c2ccc(o2)c3ccc(Cl)c(Cl)c3)c(C)c4CO[Si](C(C)C)(C(C)C)c41 4963320.0 -225000.0 -0.25 5855640.0 -45600.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A17 compound treatment 5328520.0 -762957.41935484 -0.843609912574779 -0.9824 -0.9341 3220663 PK04_107015 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)c3ccccc3C)C(C)C)oc(C(=O)C)c1C(=O)OC 4901720.0 -287000.0 -0.31 5359440.0 -542000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A18 compound treatment 5344880.0 -746597.41935484 -0.825520491304855 -1.1116 -0.9718 3070178 PK04_107016 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 4782680.0 -406000.0 -0.44 5248400.0 -653000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A19 compound treatment 5622840.0 -468637.41935484 -0.518177243371608 -0.9046 -0.9852 3220665 PK04_107017 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(Cc3ccccc3)nn2)C(C)C)oc(C(=O)C)c1C(=O)OC 4608360.0 -580000.0 -0.64 5489560.0 -412000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A20 compound treatment 5337880.0 -753597.41935484 -0.833260463730862 -1.0442 -0.9642 3070179 PK04_107018 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 4777120.0 -412000.0 -0.45 5378520.0 -523000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A21 compound treatment 5453760.0 -637717.41935484 -0.705130748770059 -1.4295 -0.9883 3220667 PK04_107019 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)C3(O)CCCCC3)C(C)C)oc(C(=O)C)c1C(=O)OC 4486160.0 -703000.0 -0.77 4903280.0 -998000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A22 compound treatment 5198760.0 -892717.41935484 -0.987086887146006 -1.8581 -0.9938 3070180 PK04_107020 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 4054440.0 -1130000.0 -1.24 4915640.0 -986000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A23 compound treatment 4761040.0 -1330437.41935484 -1.47107842004765 -2.1499 -0.987 3220669 PK04_107021 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)c3cncn3C)C(C)C)oc(C(=O)C)c1C(=O)OC 4294640.0 -894000.0 -0.98 4632240.0 -1270000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 A24 compound treatment 4360880.0 -1730597.41935484 -1.91353947233204 -2.0656 -0.8578 3070181 PK04_107022 CCCCCCc1nc(C2CC2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 4989040.0 -200000.0 -0.22 4460840.0 -1440000.0 -1.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B01 compound treatment 4925800.0 -1165677.41935484 -1.28890158334639 -1.4356 -0.9227 3188518 PK04_107023 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 4509000.0 -680000.0 -0.74 5449560.0 -452000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B02 compound treatment 5792480.0 -298997.41935484 -0.330604540179076 -0.6142 -0.9919 3188519 PK04_107024 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 4806920.0 -382000.0 -0.42 5587280.0 -314000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B03 compound treatment 6080880.0 -10597.4193548402 -0.0117176762276128 -0.1793 -0.5843 3070182 PK04_107025 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 5195680.0 7010.0 0.01 5595800.0 -305000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B04 compound treatment 6143840.0 52362.5806451598 0.0578978471925818 0.4338 0.6521 3188520 PK04_107026 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 5217440.0 28800.0 0.03 6560960.0 660000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B05 compound treatment 5976840.0 -114637.41935484 -0.126755780684999 0.1322 0.3036 3188521 PK04_107027 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 5565560.0 377000.0 0.41 5844520.0 -56800.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B06 compound treatment 5544760.0 -546717.41935484 -0.604511107231976 -0.1521 -0.2337 3070183 PK04_107028 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5340720.0 152000.0 0.17 6075240.0 174000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B07 compound treatment 6365040.0 273562.58064516 0.302480975854383 0.5134 0.9943 3188640 PK04_107029 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 5491920.0 303000.0 0.33 6155000.0 254000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B08 compound treatment 6659080.0 567602.58064516 0.627604046160514 0.8268 0.9745 3188641 PK04_107030 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5587120.0 398000.0 0.44 6268120.0 367000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B09 compound treatment 6634560.0 543082.58064516 0.600492028462561 1.014 0.9358 3070184 PK04_107031 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 5962640.0 774000.0 0.85 6208400.0 307000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B10 compound treatment 6618080.0 526602.58064516 0.582269921951049 1.0176 0.9995 3188642 PK04_107032 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 5706440.0 518000.0 0.57 6512280.0 611000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B11 compound treatment 6518600.0 427122.58064516 0.472273856674032 1.0491 0.9623 3070185 PK04_107033 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 5642880.0 454000.0 0.5 6745680.0 844000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B12 compound treatment 6662040.0 570562.58064516 0.630876948786369 0.6984 0.9206 3188643 PK04_107034 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 5517720.0 329000.0 0.36 6118960.0 218000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B13 mock treatment 6235080.0 143602.58064516 0.158782859213842 0.3704 0.6898 5161840.0 -26800.0 -0.03 6411600.0 510000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B14 mock treatment 6549600.0 458122.58064516 0.506550877417775 0.4667 0.7373 5529160.0 340000.0 0.37 5830520.0 -70800.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B15 compound treatment 6788000.0 696522.58064516 0.770152224040621 1.3348 0.9813 3188644 PK04_107035 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 6061480.0 873000.0 0.96 6485160.0 584000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B16 compound treatment 6576920.0 485442.58064516 0.536758884086131 1.3533 0.9531 3070186 PK04_107036 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 6212600.0 1020000.0 1.12 6584720.0 683000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B17 compound treatment 6317480.0 226002.58064516 0.249893391771403 0.6335 0.9136 3188645 PK04_107037 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 5732880.0 544000.0 0.6 6151760.0 250000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B18 compound treatment 6614680.0 523202.58064516 0.578510506772703 0.8671 0.9849 3188646 PK04_107038 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5533480.0 345000.0 0.38 6445040.0 544000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B19 compound treatment 6177760.0 86282.5806451598 0.0954035421483156 0.3244 0.8719 3070187 PK04_107039 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 5494120.0 305000.0 0.33 6032760.0 131000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B20 compound treatment 6463600.0 372122.58064516 0.411459787612553 0.7478 0.998 3188647 PK04_107040 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5566240.0 378000.0 0.41 6369880.0 469000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B21 compound treatment 5873880.0 -217597.41935484 -0.240599717968087 -0.4058 -0.9185 3188648 PK04_107041 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 5090320.0 -98300.0 -0.11 5548000.0 -353000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B22 compound treatment 6035600.0 -55877.4193548402 -0.0617842407204083 -1.289 -0.8258 3070188 PK04_107042 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 4376320.0 -812000.0 -0.89 4624720.0 -1280000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B23 compound treatment 5675000.0 -416477.41935484 -0.460503391694394 -0.7525 -0.9839 3188649 PK04_107043 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 4889800.0 -299000.0 -0.33 5387640.0 -514000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 B24 compound treatment 4614040.0 -1477437.41935484 -1.63361784099378 -2.0764 -0.9664 3188650 PK04_107044 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 4387280.0 -801000.0 -0.88 4819960.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C01 compound treatment 5555440.0 -536037.41935484 -0.592702120730583 -1.1976 -0.9949 3414054 PK04_107045 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 4502760.0 -686000.0 -0.75 5173440.0 -728000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C02 compound treatment 5892960.0 -198517.41935484 -0.219502764555487 -0.3463 -0.9837 3188651 PK04_107046 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5 4977280.0 -211000.0 -0.23 5753040.0 -148000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C03 compound treatment 6273680.0 182202.58064516 0.201463278591534 0.624 0.9103 3414055 PK04_107047 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(Cc4ccccc4)nn3)oc(C(=O)C)c1C(=O)OC 5723640.0 535000.0 0.59 6193760.0 292000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C04 compound treatment 6734560.0 643082.58064516 0.711063063119795 1.3233 0.983 3070235 PK04_107048 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4cc(C)c(OC)c(C)c4 5756280.0 568000.0 0.62 6857280.0 956000.0 0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C05 compound treatment 6534560.0 443082.58064516 0.489920993805327 0.6728 0.9781 3414056 PK04_107049 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 5451320.0 263000.0 0.29 6287680.0 386000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C06 compound treatment 6619400.0 527922.58064516 0.583729459608524 1.1056 0.9916 3070236 PK04_107050 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(OC)nc4 5879160.0 690000.0 0.76 6474360.0 573000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C07 compound treatment 6903000.0 811522.58064516 0.89730891389644 1.2292 0.9444 3414057 PK04_107051 CCCCc1cn(C[C@@H]2CCCN2C(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 5517960.0 329000.0 0.36 6769320.0 868000.0 0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C08 compound treatment 6847400.0 755922.58064516 0.835831418627018 0.8212 0.8767 3188655 PK04_107052 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3[C@@H](O[Si](C(C)C)(C(C)C)c31)c4ccccc4 5402920.0 214000.0 0.23 6251960.0 351000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C09 compound treatment 6800000.0 708522.58064516 0.783420748199489 1.0662 0.9817 3220705 PK04_107053 CCc1oc(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCCC3)c(C(=O)OC)c1C(=O)OC 5660040.0 471000.0 0.52 6446440.0 545000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C10 compound treatment 5887280.0 -204197.41935484 -0.225783199324018 0.6763 0.6667 3188656 PK04_107054 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)C4CC4 5797800.0 609000.0 0.67 6628800.0 728000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C11 mock treatment 6343240.0 251762.58064516 0.278376490299106 0.6272 0.9589 5457760.0 269000.0 0.29 6412720.0 511000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C12 mock treatment 6384800.0 293322.58064516 0.324329812302653 0.6397 0.996 5536360.0 348000.0 0.38 6302760.0 401000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C13 compound treatment 6665280.0 573802.58064516 0.634459450309263 0.8303 0.9579 3220708 PK04_107055 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 5451720.0 263000.0 0.29 6415040.0 514000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C14 compound treatment 7143200.0 1051722.58064516 1.16290053914312 1.4325 0.9508 3188772 PK04_107056 CCCCCCc1nc(CCCc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCCCCC)n2)c4ccccc4)cc5[C@@H](O[Si](C(C)C)(C(C)C)c51)c6ccccc6 5647760.0 459000.0 0.5 6713880.0 813000.0 0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C15 mock treatment 6207160.0 115682.58064516 0.127911426337542 0.3599 0.9365 5355040.0 166000.0 0.18 6213360.0 312000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C16 mock treatment 6388640.0 297162.58064516 0.328575740033491 0.7035 0.9816 5658640.0 470000.0 0.51 6275120.0 374000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C17 compound treatment 6577480.0 486002.58064516 0.537378081880212 1.0428 0.9886 3220711 PK04_107057 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 5678920.0 490000.0 0.54 6630680.0 729000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C18 compound treatment 6296840.0 205362.58064516 0.22707153021815 0.734 0.9319 3070242 PK04_107058 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 5566360.0 378000.0 0.41 6529760.0 628000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C19 compound treatment 6766560.0 675082.58064516 0.74644579421011 0.9839 0.9732 3220713 PK04_107059 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4N)oc(C(=O)C)c1C(=O)OC 5575000.0 386000.0 0.42 6434000.0 533000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C20 compound treatment 6287800.0 196322.58064516 0.217075908685136 0.08 0.1966 3070245 PK04_107060 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4 5372040.0 183000.0 0.2 5622920.0 -278000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C21 compound treatment 6483000.0 391522.58064516 0.432910568336057 0.3794 0.7847 3220715 PK04_107061 COC(=O)c1cn(C[C@@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 5197000.0 8330.0 0.01 6115560.0 214000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C22 compound treatment 5965040.0 -126437.41935484 -0.139803162774553 -0.2349 -0.9861 3070527 PK04_107062 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)cc(OC)c1OC 5041480.0 -147000.0 -0.16 5795880.0 -105000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C23 compound treatment 5882920.0 -208557.41935484 -0.230604096435073 -0.4405 -0.4639 3220717 PK04_107063 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4)oc(C(=O)N5CCOCC5)c1C(=O)OC 5488440.0 300000.0 0.33 5043640.0 -858000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 C24 compound treatment 5361760.0 -729717.41935484 -0.806856100654714 -1.3644 -0.9702 3070530 PK04_107064 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)C4CC4)C(C)C 4697680.0 -491000.0 -0.54 4886320.0 -1010000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D01 compound treatment 5519320.0 -572157.41935484 -0.632640378448776 -0.8309 -0.9564 3188777 PK04_107065 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 4709760.0 -479000.0 -0.52 5620160.0 -281000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D02 compound treatment 6349320.0 257842.58064516 0.285099209206266 0.0243 0.0647 3188778 PK04_107066 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 4965280.0 -223000.0 -0.24 5902920.0 1630.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D03 compound treatment 6152200.0 60722.5806451598 0.0671415856899266 0.2516 0.7042 3070575 PK04_107067 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 5508720.0 320000.0 0.35 5919400.0 18100.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D04 compound treatment 6261240.0 169762.58064516 0.187708241880175 0.6939 0.8698 3188779 PK04_107068 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5461280.0 273000.0 0.3 6614320.0 713000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D05 compound treatment 5913880.0 -177597.41935484 -0.196371304105194 0.1899 0.412 3188780 PK04_107069 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 5550840.0 362000.0 0.4 6029480.0 128000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D06 compound treatment 6601240.0 509762.58064516 0.56364975971477 1.2169 0.9877 3070579 PK04_107070 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5952200.0 764000.0 0.84 6606760.0 705000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D07 compound treatment 6575400.0 483922.58064516 0.535078204359341 1.1282 0.985 3188781 PK04_107071 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 5748000.0 559000.0 0.61 6704960.0 804000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D08 compound treatment 6944640.0 853162.58064516 0.943350692727712 1.3429 0.9802 3188782 PK04_107072 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 5705640.0 517000.0 0.57 6714880.0 814000.0 0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D09 compound treatment 6804840.0 713362.58064516 0.788772386276899 1.1198 0.9645 3188783 PK04_107073 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 5551360.0 363000.0 0.4 6652240.0 751000.0 0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D10 compound treatment 6540240.0 448762.58064516 0.496201428573858 0.9935 0.9867 3070632 PK04_107074 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 5833920.0 645000.0 0.71 6417480.0 516000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D11 mock treatment 6814160.0 722682.58064516 0.799077606706953 1.0623 0.9384 5458440.0 270000.0 0.3 6644000.0 743000.0 0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D12 mock treatment 6922800.0 831322.58064516 0.919201978758572 1.2728 0.945 5531120.0 342000.0 0.38 6808360.0 907000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D13 compound treatment 6632840.0 541362.58064516 0.598590206666456 1.1465 0.9694 3188784 PK04_107075 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 6002680.0 814000.0 0.89 6395280.0 494000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D14 compound treatment 6789800.0 698322.58064516 0.772142502664451 1.1962 0.9961 3188785 PK04_107076 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 5758960.0 570000.0 0.62 6574160.0 673000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D15 mock treatment 6783320.0 691842.58064516 0.764977499618662 1.2925 0.9961 5788640.0 600000.0 0.66 6715040.0 814000.0 0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D16 mock treatment 6640120.0 548642.58064516 0.606639777989503 1.132 0.9971 5765600.0 577000.0 0.63 6620960.0 720000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D17 compound treatment 6216040.0 124562.58064516 0.137730134215105 1.3383 0.8617 3070637 PK04_107077 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 6267120.0 1080000.0 1.18 6896920.0 996000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D18 compound treatment 6546800.0 455322.58064516 0.503454888447372 0.7997 0.996 3188786 PK04_107078 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5558720.0 370000.0 0.41 6375960.0 475000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D19 compound treatment 6334200.0 242722.58064516 0.268380868766093 0.9654 0.9308 3188787 PK04_107079 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 5917200.0 729000.0 0.8 6504960.0 604000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D20 compound treatment 6862080.0 770602.58064516 0.8520632465147 1.1652 0.9632 3070641 PK04_107080 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5876040.0 687000.0 0.75 6313200.0 412000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D21 compound treatment 6513440.0 421962.58064516 0.466568391285719 0.6285 0.9122 3188905 PK04_107081 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 5635440.0 447000.0 0.49 6033560.0 132000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D22 compound treatment 6599720.0 508242.58064516 0.56196907998798 0.048 0.0705 3188906 PK04_107082 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 5089560.0 -99100.0 -0.11 5532360.0 -369000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D23 compound treatment 5783520.0 -307957.41935484 -0.340511704884364 -0.6317 -0.9734 3070684 PK04_107083 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 4938720.0 -250000.0 -0.27 5423040.0 -478000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 D24 compound treatment 5580440.0 -511037.41935484 -0.565059362066275 -1.0934 -0.9593 3188907 PK04_107084 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 4380760.0 -808000.0 -0.88 5458840.0 -442000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E01 mock treatment 5393080.0 -698397.41935484 -0.772225252600069 -0.8553 -0.9072 4733920.0 -455000.0 -0.5 5690840.0 -210000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E02 mock treatment 5865520.0 -225957.41935484 -0.249843456465432 -0.2586 -0.7474 4972920.0 -216000.0 -0.24 5939360.0 38100.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E03 compound treatment 6425800.0 334322.58064516 0.369663936512119 0.4001 0.9204 3220739 PK04_107085 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)N5CCOCC5)c1C(=O)OC 5339040.0 150000.0 0.16 6059320.0 158000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E04 compound treatment 6267960.0 176482.58064516 0.195138615409141 0.7809 0.8879 3070690 PK04_107086 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C(=C)C 5882480.0 694000.0 0.76 6297440.0 396000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E05 compound treatment 6805240.0 713762.58064516 0.789214670415528 0.6471 0.6771 3220741 PK04_107087 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCC4)oc(C(=O)N5CCOCC5)c1C(=O)OC 5653320.0 465000.0 0.51 5724600.0 -177000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E06 compound treatment 6459840.0 368362.58064516 0.407302316709441 0.7597 0.9871 3070694 PK04_107088 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 5527760.0 339000.0 0.37 6436640.0 535000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E07 compound treatment 6446720.0 355242.58064516 0.392795396962412 0.9426 0.9404 3220743 PK04_107089 COCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)N4CCOCC4)c(C(=O)OC)c3C(=O)OC)nn1 5939320.0 751000.0 0.82 6317600.0 416000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E08 compound treatment 6985680.0 894202.58064516 0.988729045351041 1.2139 0.9603 3188910 PK04_107090 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)c5ccc(o5)c6ccc(Cl)c(Cl)c6)C(C)C 5703400.0 515000.0 0.56 6449520.0 548000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E09 mock treatment 6861720.0 770242.58064516 0.851665190789934 1.3478 0.9627 6103200.0 915000.0 1.0 6380920.0 480000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E10 mock treatment 6520360.0 428882.58064516 0.474219906883999 0.8235 0.9383 5427480.0 239000.0 0.26 6589480.0 688000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E11 compound treatment 6556720.0 465242.58064516 0.51442353508537 1.053 0.9854 3188911 PK04_107091 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 5877960.0 689000.0 0.75 6453960.0 553000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E12 compound treatment 6134920.0 43442.5806451598 0.0480349109011565 0.8421 0.8262 3070742 PK04_107092 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 5700600.0 512000.0 0.56 6748240.0 847000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E13 compound treatment 6622880.0 531402.58064516 0.587577331614596 1.5048 0.9527 3188912 PK04_107093 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](C)Cn3cc(CN(C)C2=O)nn3 5894360.0 706000.0 0.77 7142920.0 1240000.0 1.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E14 compound treatment 6885440.0 793962.58064516 0.87789264021063 1.1979 0.9657 3070746 PK04_107094 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 5588320.0 400000.0 0.44 6657840.0 757000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E15 compound treatment 7089120.0 997642.58064516 1.10310372360048 1.3652 0.9577 3188913 PK04_107095 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 5674280.0 486000.0 0.53 6628440.0 727000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E16 compound treatment 6068080.0 -23397.4193548402 -0.0258707686637387 0.37 0.6778 3070750 PK04_107096 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 5316200.0 128000.0 0.14 6426560.0 525000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E17 mock treatment 6444360.0 352882.58064516 0.390185920544502 0.4969 0.8348 5208320.0 19700.0 0.02 6348680.0 447000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E18 mock treatment 6234640.0 143162.58064516 0.15829634666135 0.8256 0.8597 5577000.0 388000.0 0.43 6744720.0 843000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E19 compound treatment 6223640.0 132162.58064516 0.146133532849055 0.9295 0.8656 3220747 PK04_107097 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCCC2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 5698440.0 510000.0 0.56 6803560.0 902000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E20 compound treatment 5957560.0 -133917.41935484 -0.148073876166914 0.0504 0.226 3188915 PK04_107098 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)C(C)C 5301800.0 113000.0 0.12 6012320.0 111000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E21 compound treatment 5927560.0 -163917.41935484 -0.181245186564084 0.4538 0.6393 3220749 PK04_107099 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCC(C)C)oc(C(=O)Cc2ccccc2)c1C(=O)OC 5593640.0 405000.0 0.44 6423240.0 522000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E22 compound treatment 5856000.0 -235477.41935484 -0.260369818964801 0.1385 0.3031 3070803 PK04_107100 CC(C)[Si](O[Si](C#Cc1ccc(Oc2ccccc2)cc1)(C(C)C)C(C)C)(C#Cc3ccc(Oc4ccccc4)cc3)C(C)C 5335960.0 147000.0 0.16 6238960.0 338000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E23 compound treatment 6208520.0 117042.58064516 0.129415192408881 0.2582 0.9952 3220751 PK04_107101 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2ccc(OC)cc2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 5339120.0 150000.0 0.16 6053720.0 152000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 E24 compound treatment 5318880.0 -772597.41935484 -0.854268960315736 -0.7453 -0.8173 3070808 PK04_107102 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)c6ccccc6)C(C)C 4937000.0 -252000.0 -0.28 5740840.0 -160000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F01 mock treatment 5684240.0 -407237.41935484 -0.450286628092066 -0.9191 -0.9885 4732000.0 -457000.0 -0.5 5262040.0 -639000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F02 mock treatment 6251160.0 159682.58064516 0.176562681586725 -0.0861 -0.2956 5023560.0 -165000.0 -0.18 5756880.0 -144000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F03 compound treatment 6316280.0 224802.58064516 0.248566539355516 0.5559 0.9464 3188918 PK04_107103 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 5623000.0 434000.0 0.48 6139000.0 238000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F04 compound treatment 6281520.0 190042.58064516 0.210132047708662 0.6825 0.9471 3188919 PK04_107104 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5598880.0 410000.0 0.45 6422240.0 521000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F05 compound treatment 6786480.0 695002.58064516 0.768471544313831 1.0571 0.9786 3188920 PK04_107105 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5603640.0 415000.0 0.45 6507160.0 606000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F06 compound treatment 6489560.0 398082.58064516 0.440164028209571 1.3087 0.953 3188921 PK04_107106 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5922880.0 734000.0 0.8 6920200.0 1020000.0 1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F07 compound treatment 6429920.0 338442.58064516 0.374219463139997 1.4176 0.9327 3070852 PK04_107107 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 6094640.0 906000.0 0.99 6986320.0 1090000.0 1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F08 compound treatment 7103360.0 1011882.58064516 1.11884903893567 1.1091 0.8766 3188922 PK04_107108 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5448560.0 260000.0 0.28 6416920.0 516000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F09 mock treatment 6613120.0 521642.58064516 0.57678559863205 1.1035 0.9607 5597600.0 409000.0 0.45 6784840.0 884000.0 0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F10 mock treatment 6795360.0 703882.58064516 0.778290252191393 1.2725 0.9934 5927760.0 739000.0 0.81 6515400.0 614000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F11 compound treatment 6495720.0 404242.58064516 0.446975203944457 0.8344 0.9401 3189029 PK04_107109 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 5837800.0 649000.0 0.71 6187640.0 286000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F12 compound treatment 6357320.0 265842.58064516 0.293944891978845 0.9747 0.9471 3070859 PK04_107110 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5841560.0 653000.0 0.71 6578200.0 677000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F13 compound treatment 6646600.0 555122.58064516 0.613804781035292 1.7284 0.9252 3189030 PK04_107111 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 5932720.0 744000.0 0.81 7460760.0 1560000.0 1.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F14 compound treatment 7286440.0 1194962.58064516 1.32128248918614 1.5747 0.9519 3189031 PK04_107112 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5802560.0 614000.0 0.67 6632560.0 731000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F15 compound treatment 6736240.0 644762.58064516 0.712920656502036 0.9088 0.9638 3070862 PK04_107113 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 5646480.0 458000.0 0.5 6259760.0 358000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F16 compound treatment 6336320.0 244842.58064516 0.270724974700826 0.7966 0.9384 3189032 PK04_107114 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 5811240.0 623000.0 0.68 6326920.0 426000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F17 mock treatment 6599120.0 507642.58064516 0.561305653780037 0.7923 0.9759 5479280.0 291000.0 0.32 6392360.0 491000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F18 mock treatment 6775280.0 683802.58064516 0.75608758843222 0.9964 0.974 5675880.0 487000.0 0.53 6335880.0 435000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F19 compound treatment 6882560.0 791082.58064516 0.874708194412501 1.3402 0.985 3189033 PK04_107115 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5977920.0 789000.0 0.86 6481400.0 580000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F20 compound treatment 6063080.0 -28397.4193548402 -0.0313993203966004 0.517 0.7632 3070022 PK04_107116 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 5503160.0 314000.0 0.34 6481680.0 580000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F21 compound treatment 5697840.0 -393637.41935484 -0.435248967378682 0.1018 0.1617 3189034 PK04_107117 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5558000.0 369000.0 0.4 6107600.0 206000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F22 compound treatment 6583160.0 491682.58064516 0.543658516648742 0.6412 0.947 3189035 PK04_107118 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 5477200.0 289000.0 0.32 6151280.0 250000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F23 compound treatment 5976880.0 -114597.41935484 -0.126711552271136 -0.1771 -0.6045 3070031 PK04_107119 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 4957040.0 -232000.0 -0.25 5974680.0 73400.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 F24 compound treatment 5244160.0 -847317.41935484 -0.936887637411622 -1.2238 -0.9406 3189036 PK04_107120 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 4429120.0 -760000.0 -0.83 5551560.0 -350000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G01 compound treatment 5968000.0 -123477.41935484 -0.136530260148699 -0.5736 -0.9233 3220772 PK04_107121 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCc2c[nH]c3ccccc23)oc(C(=O)Cc4ccccc4)c1C(=O)OC 4804080.0 -385000.0 -0.42 5467120.0 -434000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G02 compound treatment 6303080.0 211602.58064516 0.233971162780761 0.1988 0.7826 3070078 PK04_107122 CC[C@@H]1O[Si](C(C)C)(C(C)C)c2c1cc(nc2c3ccc(Oc4ccccc4)cc3)c5cc(C)c(OC)c(C)c5 5199840.0 11200.0 0.01 5999000.0 97700.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G03 mock treatment 6376080.0 284602.58064516 0.314688018080542 0.3433 0.8859 5387040.0 198000.0 0.22 5963680.0 62400.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G04 mock treatment 6436800.0 345322.58064516 0.381826750324415 0.2071 0.5234 5244200.0 55500.0 0.06 5817640.0 -83600.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G05 compound treatment 6940040.0 848562.58064516 0.938264425133479 1.2738 0.9812 3220775 PK04_107123 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2nc[nH]n2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 5747880.0 559000.0 0.61 6554600.0 653000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G06 compound treatment 6833760.0 742282.58064516 0.820749529499771 1.4806 0.8976 3070081 PK04_107124 CC(C)[Si]1(OCc2c1c(nc(c3ccc(o3)c4ccc(Cl)c(Cl)c4)c2C)c5ccccc5)C(C)C 6453480.0 1260000.0 1.39 6258560.0 357000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G07 compound treatment 6727160.0 635682.58064516 0.702880806555159 1.3884 0.9948 3189039 PK04_107125 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccc3 5916880.0 728000.0 0.8 6802560.0 901000.0 0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G08 compound treatment 6550040.0 458562.58064516 0.507037389970266 1.2526 0.9255 3189040 PK04_107126 COc1c(C)cc(cc1C)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 6231200.0 1040000.0 1.14 6420320.0 519000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G09 compound treatment 6777280.0 685802.58064516 0.758299009125365 0.977 0.8032 3070086 PK04_107127 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(CCCNC(=N)N)nn2 6057000.0 868000.0 0.95 5884280.0 -17000.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G10 compound treatment 6810080.0 718602.58064516 0.794566308492938 1.6651 0.987 3189041 PK04_107128 COc1ccc(cn1)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 6027160.0 838000.0 0.92 7068400.0 1170000.0 1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G11 compound treatment 7146880.0 1055402.58064516 1.1669695532185 1.67 0.9755 3070089 PK04_107129 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccc2 5793800.0 605000.0 0.66 6960360.0 1060000.0 1.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G12 compound treatment 6851280.0 759802.58064516 0.840121574771718 1.7429 0.9932 3189042 PK04_107130 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 6168480.0 980000.0 1.07 7003000.0 1100000.0 1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G13 compound treatment 6838000.0 746522.58064516 0.825437741369238 1.9113 0.9839 3070134 PK04_107131 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)C3(O)CCCCC3 6279080.0 1090000.0 1.19 7187600.0 1290000.0 1.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G14 compound treatment 7076720.0 985242.58064516 1.08939291530299 1.4245 0.9684 3070137 PK04_107132 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 5925120.0 736000.0 0.81 6470720.0 569000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G15 compound treatment 5966120.0 -125357.41935484 -0.138608995600255 0.4949 0.628 3189043 PK04_107133 N[C@@H](Cc1ccccc1)Cn2cc(nn2)C3(O)CCCCC3 5853600.0 665000.0 0.73 6168000.0 267000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G16 compound treatment 6463880.0 372402.58064516 0.411769386509594 1.4168 0.9342 3189044 PK04_107134 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 6258240.0 1070000.0 1.17 6769040.0 868000.0 0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G17 compound treatment 6090480.0 -997.419354840182 -0.0011028569005183 0.8133 0.7456 3070143 PK04_107135 N[C@@H](Cc1ccccc1)Cn2cc(nn2)c3ccccc3 5546320.0 358000.0 0.39 6915720.0 1010000.0 1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G18 compound treatment 5623120.0 -468357.41935484 -0.517867644474567 0.2491 0.2909 3189045 PK04_107136 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)C4CC4)c5ccccc5)C(C)C 5698800.0 510000.0 0.56 6290480.0 389000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G19 mock treatment 6213960.0 122482.58064516 0.135430256694234 -0.0791 -0.1368 4723360.0 -465000.0 -0.51 6137600.0 236000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G20 mock treatment 6052040.0 -39437.4193548402 -0.0436063626227591 0.5961 0.7703 5593360.0 405000.0 0.44 6532000.0 631000.0 0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G21 compound treatment 6262200.0 170722.58064516 0.188769723812884 0.6038 0.8405 3070191 PK04_107137 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(Cc3ccccc3)nn2 5362760.0 174000.0 0.19 6565320.0 664000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G22 compound treatment 6368800.0 277322.58064516 0.306638446757496 0.2123 0.6417 3189046 PK04_107138 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 5291760.0 103000.0 0.11 5849640.0 -51600.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G23 compound treatment 5987800.0 -103677.41935484 -0.114637195286566 -0.072 -0.516 3070196 PK04_107139 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccn2 5132880.0 -55800.0 -0.06 5952120.0 50800.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 G24 compound treatment 5174920.0 -916557.41935484 -1.01344702180829 -1.4773 -0.9551 3189047 PK04_107140 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 4750520.0 -438000.0 -0.48 4839560.0 -1060000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H01 compound treatment 5737920.0 -353557.41935484 -0.390932096688063 -0.6045 -0.9152 3189157 PK04_107141 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 5057720.0 -131000.0 -0.14 5390400.0 -511000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H02 compound treatment 5913200.0 -178277.41935484 -0.197123187140863 -0.1206 -0.591 3189158 PK04_107142 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 5217120.0 28500.0 0.03 5858440.0 -42800.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H03 mock treatment 5984720.0 -106757.41935484 -0.118042783154009 0.3495 0.6204 5650920.0 462000.0 0.51 6117720.0 216000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H04 mock treatment 6308520.0 217042.58064516 0.239986227066115 0.4465 0.9307 5544600.0 356000.0 0.39 6044400.0 143000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H05 compound treatment 6709640.0 618162.58064516 0.683508761283212 0.5393 0.7637 3070201 PK04_107143 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 5296080.0 107000.0 0.12 6033760.0 132000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H06 compound treatment 6940840.0 849362.58064516 0.939148993410737 1.5557 0.9986 3189159 PK04_107144 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 6032720.0 844000.0 0.92 6729360.0 828000.0 0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H07 compound treatment 6956680.0 865202.58064516 0.956663445300443 1.4103 0.9841 3071172 PK04_107145 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5987160.0 798000.0 0.87 6510680.0 609000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H08 compound treatment 6630600.0 539122.58064516 0.596113415490134 0.8415 0.92 3071173 PK04_107146 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 5796400.0 608000.0 0.67 6096440.0 195000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H09 compound treatment 6768840.0 677362.58064516 0.748966813800295 0.9014 0.9376 3071174 PK04_107147 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5677680.0 489000.0 0.54 6177080.0 276000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H10 compound treatment 6860520.0 769042.58064516 0.850338338374047 1.6399 0.9772 3189160 PK04_107148 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 6314480.0 1130000.0 1.23 6655760.0 754000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H11 compound treatment 7128240.0 1036762.58064516 1.14635911235839 1.1472 0.856 3189161 PK04_107149 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 5341040.0 152000.0 0.17 6572680.0 671000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H12 compound treatment 6842160.0 750682.58064516 0.830037496410979 1.3243 0.9951 3071175 PK04_107150 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5789320.0 601000.0 0.66 6704280.0 803000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H13 compound treatment 7286040.0 1194562.58064516 1.32084020504751 2.4453 0.9223 3189162 PK04_107151 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 5861800.0 673000.0 0.74 8070880.0 2170000.0 2.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H14 compound treatment 6719800.0 628322.58064516 0.694742778404387 0.9837 0.9439 3189163 PK04_107152 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5847640.0 659000.0 0.72 6187600.0 286000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H15 compound treatment 6386480.0 295002.58064516 0.326187405684894 0.9395 0.9592 3071176 PK04_107153 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 5834600.0 646000.0 0.71 6492840.0 592000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H16 compound treatment 4662640.0 -1428837.41935484 -1.57988031815037 -0.2773 -0.1575 3189164 PK04_107154 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5709040.0 520000.0 0.57 6429040.0 528000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H17 compound treatment 6548240.0 456762.58064516 0.505047111346436 0.6459 0.8223 3189165 PK04_107155 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 5199840.0 11200.0 0.01 6500560.0 599000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H18 compound treatment 6453880.0 362402.58064516 0.40071228304387 0.8831 0.9887 3071177 PK04_107156 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5702240.0 514000.0 0.56 6465720.0 564000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H19 mock treatment 6647680.0 556202.58064516 0.61499894820959 0.8701 0.7661 5133080.0 -55600.0 -0.06 6850840.0 950000.0 0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H20 mock treatment 5724760.0 -366717.41935484 -0.405483244848955 0.0216 0.0408 5305400.0 117000.0 0.13 6215200.0 314000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H21 compound treatment 4178080.0 -1913397.41935484 -2.11566332368546 -1.431 -0.6667 3189166 PK04_107157 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5188000.0 -666.0 0.0 5540480.0 -361000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H22 compound treatment 5474760.0 -616717.41935484 -0.68191083149204 -0.4338 -0.613 3189167 PK04_107158 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5038960.0 -150000.0 -0.16 5995480.0 94200.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H23 compound treatment 4972880.0 -1118597.41935484 -1.23684474022977 -0.9075 -0.6934 3071178 PK04_107159 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 5266000.0 77300.0 0.08 5483120.0 -418000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 H24 compound treatment 4493000.0 -1598477.41935484 -1.7674530213429 -1.8754 -0.9125 3189168 PK04_107160 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 4474080.0 -715000.0 -0.78 5205520.0 -696000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I01 compound treatment 5228520.0 -862957.41935484 -0.954180947232013 -1.4563 -0.9881 3071179 PK04_107161 CC(C)[C@@H](C(=O)O)n1cc(nn1)C2(O)CCCCC2 4357120.0 -832000.0 -0.91 5246040.0 -655000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I02 compound treatment 5861800.0 -229677.41935484 -0.253956698954681 -0.6619 -0.9664 3189169 PK04_107162 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 4832720.0 -356000.0 -0.39 5400440.0 -501000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I03 compound treatment 5926200.0 -165277.41935484 -0.182748952635422 -0.081 -0.3432 3071180 PK04_107163 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccn3 5113720.0 -74900.0 -0.08 6025440.0 124000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I04 compound treatment 6182440.0 90962.5806451598 0.100578266570274 -0.1376 -0.4084 3189170 PK04_107164 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)cc(OC)c1OC 4895520.0 -293000.0 -0.32 5883480.0 -17800.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I05 mock treatment 5841640.0 -249837.41935484 -0.27624781954158 -0.1692 -0.4341 5358280.0 170000.0 0.19 5699520.0 -202000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I06 mock treatment 6211320.0 119842.58064516 0.132511181379283 0.1286 0.8635 5214800.0 26100.0 0.03 5962600.0 61300.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I07 compound treatment 6339520.0 248042.58064516 0.274263247809857 0.7413 0.8292 3071181 PK04_107165 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@]4(O[C@@]23[C@H]5[C@@H]4C(=O)N(C)C5=O)C(=O)C)c1 5948600.0 760000.0 0.83 6078200.0 177000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I08 compound treatment 6758000.0 666522.58064516 0.73698091364345 0.9388 0.9569 3189171 PK04_107166 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 5695080.0 506000.0 0.55 6234520.0 333000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I09 compound treatment 6325160.0 233682.58064516 0.258385247233079 0.6266 0.7281 3189172 PK04_107167 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@@]4(O[C@]23[C@@H]5[C@H]4C(=O)N(C)C5=O)C(=O)C)c1 5938200.0 750000.0 0.82 5907280.0 5990.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I10 compound treatment 6345120.0 253642.58064516 0.280455225750663 0.592 0.992 3071182 PK04_107168 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 5526880.0 338000.0 0.37 6274480.0 373000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I11 compound treatment 6362840.0 271362.58064516 0.300048413091924 0.5383 0.9958 3189173 PK04_107169 NC(=N)NCc1cn(CCc2c[nH]c3ccccc23)nn1 5446400.0 258000.0 0.28 6250120.0 349000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I12 compound treatment 6308720.0 217242.58064516 0.240207369135429 0.7714 0.9482 3189286 PK04_107170 CC(C)[Si]1(O[C@H](c2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 5650240.0 462000.0 0.51 6489600.0 588000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I13 compound treatment 6219320.0 127842.58064516 0.141356864151862 0.562 0.922 3071183 PK04_107171 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@H](Cc4ccccc4)C(=O)N23 5521200.0 333000.0 0.36 6367480.0 466000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I14 compound treatment 7039120.0 947642.58064516 1.04781820627187 1.3927 0.9645 3189287 PK04_107172 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 5658520.0 470000.0 0.51 6748200.0 847000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I15 compound treatment 7303080.0 1211602.58064516 1.3396815093531 1.2241 0.8187 3071184 PK04_107173 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@@H](Cc4ccccc4)C(=O)N23 5306880.0 118000.0 0.13 6550000.0 649000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I16 compound treatment 6568280.0 476802.58064516 0.527205546691746 1.0839 0.9521 3189288 PK04_107174 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 5594200.0 406000.0 0.44 6804040.0 903000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I17 compound treatment 6112280.0 20802.5806451598 0.0230016286547587 0.1814 0.8464 3071185 PK04_107175 COc1ccc(cc1)[C@H]2OC[C@@H]3CC4(CC=CC4)C(=O)N23 5357000.0 168000.0 0.18 6007760.0 106000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I18 compound treatment 6085920.0 -5557.41935484018 -0.00614489608088817 -0.2635 -0.7941 3189289 PK04_107176 COc1cc(Cc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5)cc(OC)c1OC 5043280.0 -145000.0 -0.16 5611240.0 -290000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I19 compound treatment 5710840.0 -380637.41935484 -0.420874732873242 0.0166 0.0288 3071186 PK04_107177 COc1ccc(cc1)[C@H]2OC[C@@H]3CCC(=O)N23 5545520.0 357000.0 0.39 5959960.0 58700.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I20 compound treatment 5751560.0 -339917.41935484 -0.375850207560816 -0.039 -0.0743 3189171 PK04_107178 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 5138880.0 -49800.0 -0.05 6262760.0 361000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I21 mock treatment 5552840.0 -538637.41935484 -0.595576967631671 -0.611 -0.8562 4836720.0 -352000.0 -0.39 5824240.0 -77000.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I22 mock treatment 5567720.0 -523757.41935484 -0.579123997674675 -0.7201 -0.9631 4896600.0 -292000.0 -0.32 5554320.0 -347000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I23 compound treatment 5726440.0 -365037.41935484 -0.403625651466713 -1.254 -0.8944 3189290 PK04_107179 COc1ccc(cc1)[C@H]2OC[C@@H]3CC(CC=C)(CC=C)C(=O)N23 4065400.0 -1120000.0 -1.23 5364920.0 -536000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 I24 compound treatment 4873000.0 -1218477.41935484 -1.34728308964541 -1.9316 -0.9828 3071182 PK04_107180 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 4422320.0 -766000.0 -0.84 4746240.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J01 compound treatment 5523440.0 -568037.41935484 -0.628084851820898 -1.0778 -0.9974 3189291 PK04_107181 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 4672840.0 -516000.0 -0.56 5229800.0 -671000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J02 compound treatment 5645080.0 -446397.41935484 -0.493586245263839 -1.1203 -0.9826 3071187 PK04_107182 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 4591720.0 -597000.0 -0.65 5111000.0 -790000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J03 compound treatment 6210320.0 118842.58064516 0.131405471032711 0.1167 0.5638 3189292 PK04_107183 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 5122880.0 -65800.0 -0.07 6043560.0 142000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J04 compound treatment 5997120.0 -94357.4193548402 -0.104331974856512 0.0633 0.144 3189293 PK04_107184 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5028520.0 -160000.0 -0.18 6289280.0 388000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J05 mock treatment 5954120.0 -137357.41935484 -0.151877519759123 -0.1826 -0.3572 5419640.0 231000.0 0.25 5485480.0 -416000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J06 mock treatment 6485720.0 394242.58064516 0.435918100478734 0.5004 0.882 5513000.0 324000.0 0.36 5976640.0 75400.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J07 compound treatment 6130160.0 38682.5806451598 0.0427717296514722 0.2759 0.6742 3071188 PK04_107185 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 5215320.0 26700.0 0.03 6305800.0 405000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J08 compound treatment 5473480.0 -617997.41935484 -0.683326140735652 -0.4237 -0.5738 3189294 PK04_107186 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5344760.0 156000.0 0.17 5680600.0 -221000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J09 compound treatment 5910400.0 -181077.41935484 -0.200219176111265 0.0923 0.2645 3189295 PK04_107187 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5269040.0 80400.0 0.09 6172440.0 271000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J10 compound treatment 6164280.0 72802.5806451598 0.0804985666765204 0.0523 0.3144 3071189 PK04_107188 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5099360.0 -89300.0 -0.1 6008840.0 108000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J11 compound treatment 6293320.0 201842.58064516 0.223179429798215 0.3639 0.9449 3189296 PK04_107189 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 5293760.0 105000.0 0.12 6192240.0 291000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J12 compound treatment 6361320.0 269842.58064516 0.298367733365134 0.7407 0.9219 3189297 PK04_107190 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5811160.0 622000.0 0.68 6203000.0 302000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J13 compound treatment 6325520.0 234042.58064516 0.258783302957845 0.2907 0.7558 3071190 PK04_107191 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 5446160.0 257000.0 0.28 5864080.0 -37200.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J14 compound treatment 7228600.0 1137122.58064516 1.25732820274039 0.1798 0.1178 3189298 PK04_107192 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 4401280.0 -787000.0 -0.86 5818040.0 -83200.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J15 compound treatment 6574760.0 483282.58064516 0.534370549737535 0.6637 0.9136 3071191 PK04_107193 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 5618240.0 430000.0 0.47 6045560.0 144000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J16 compound treatment 6161240.0 69762.5806451598 0.0771372072229405 -0.139 -0.4846 3189299 PK04_107194 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 4939800.0 -249000.0 -0.27 5856080.0 -45200.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J17 compound treatment 4301280.0 -1790197.41935484 -1.97943980898775 -1.6935 -0.7749 3189300 PK04_107195 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 5162960.0 -25700.0 -0.03 4978920.0 -922000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J18 compound treatment 5410760.0 -680717.41935484 -0.75267629367267 -0.5044 -0.5726 3071192 PK04_107196 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 4843000.0 -346000.0 -0.38 6157880.0 257000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J19 compound treatment 5960560.0 -130917.41935484 -0.144756745127197 0.2396 0.5389 3189301 PK04_107197 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5535800.0 347000.0 0.38 6080280.0 179000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J20 compound treatment 5830560.0 -260917.41935484 -0.288499090181601 -0.5079 -0.9671 3189302 PK04_107198 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 4832520.0 -356000.0 -0.39 5700800.0 -200000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J21 mock treatment 5831520.0 -259957.41935484 -0.287437608248892 -0.3115 -0.8381 4974120.0 -215000.0 -0.23 5884240.0 -17000.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J22 mock treatment 7287560.0 1196082.58064516 1.3225208847743 0.4394 0.3144 4793040.0 -396000.0 -0.43 5773600.0 -128000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J23 compound treatment 5262840.0 -828637.41935484 -0.91623296813765 -1.3015 -0.9537 3071251 PK04_107199 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 4808560.0 -380000.0 -0.42 4982880.0 -918000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 J24 compound treatment 5318480.0 -772997.41935484 -0.854711244454365 -1.9639 -0.9782 3189414 PK04_107200 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 4180000.0 -1010000.0 -1.1 4464120.0 -1440000.0 -1.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K01 compound treatment 4957400.0 -1134077.41935484 -1.25396113639471 -2.0961 -0.9908 3071252 PK04_107201 COc1cccc(C[C@H]2C[C@@H](CO)NC2=O)c1 3921720.0 -1270000.0 -1.39 4915720.0 -986000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K02 compound treatment 5171880.0 -919597.41935484 -1.01680838126187 -1.1693 -0.9236 3189415 PK04_107202 CCCCCCC#C[Si](O[C@@H](C#C)c1ccccc1)(C(C)C)C(C)C 4569680.0 -619000.0 -0.68 5571800.0 -329000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K03 compound treatment 5890040.0 -201437.41935484 -0.222731438767478 -0.1002 -0.319 3071253 PK04_107203 COC(=O)c1c(CC[C@@H](CO)NC(=O)N(C)Cc2ccccc2)oc(C(=O)OCC=C)c1C(=O)OC 5069960.0 -119000.0 -0.13 6079880.0 179000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K04 compound treatment 5413600.0 -677877.41935484 -0.749536076288404 -0.9387 -0.922 3189416 PK04_107204 CCCCCCC#C[Si](OCC#CC)(C(C)C)C(C)C 4594040.0 -595000.0 -0.65 5676920.0 -224000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K05 compound treatment 6027760.0 -63717.4193548402 -0.0704530098375355 -0.1008 -0.4723 3189417 PK04_107205 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(COC2=O)nn4 5262200.0 73500.0 0.08 5717280.0 -184000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K06 compound treatment 6131680.0 40202.5806451598 0.0444524093782621 0.36 0.8595 3071254 PK04_107206 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccccc2)C(C)C 5502160.0 313000.0 0.34 6136240.0 235000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K07 mock treatment 6058720.0 -32757.4193548402 -0.0362202175076558 0.3239 0.4292 5864360.0 676000.0 0.74 5759000.0 -142000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K08 mock treatment 5430280.0 -661197.41935484 -0.731092827707577 -0.4441 -0.519 4884840.0 -304000.0 -0.33 6194880.0 294000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K09 compound treatment 5452600.0 -638877.41935484 -0.706413372772083 -0.2052 -0.2738 3071255 PK04_107207 NC(=N)NCC#C 5329080.0 140000.0 0.15 6097800.0 197000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K10 compound treatment 6502720.0 411242.58064516 0.454715176370463 0.1801 0.3729 3189418 PK04_107208 CC#CCO[Si](C#Cc1ccccc1)(C(C)C)C(C)C 5040840.0 -148000.0 -0.16 5920400.0 19100.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K11 compound treatment 6509520.0 418042.58064516 0.462234006727155 0.4974 0.8595 3189419 PK04_107209 OC(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 5239400.0 50700.0 0.06 6243800.0 343000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K12 compound treatment 6579120.0 487642.58064516 0.53919144684859 0.7835 0.9316 3071256 PK04_107210 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccc(Oc3ccccc3)cc2)C(C)C 5747160.0 558000.0 0.61 6106880.0 206000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K13 compound treatment 5935320.0 -156157.41935484 -0.172664874274683 -0.1717 -0.6911 3189420 PK04_107211 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@](Cc4ccccc4)(C(=O)OCC=C)C(=O)N23 5031480.0 -157000.0 -0.17 5948600.0 47300.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K14 compound treatment 6486760.0 395282.58064516 0.437068039239169 0.4866 0.8083 3071257 PK04_107212 CC[C@@H](O[Si](C#Cc1ccc(Oc2ccccc2)cc1)(C(C)C)C(C)C)C#C 5566680.0 378000.0 0.41 5893160.0 -8130.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K15 mock treatment 5942000.0 -149477.41935484 -0.165278729159579 0.0136 0.0572 5205960.0 17300.0 0.02 6070560.0 169000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K16 mock treatment 6221840.0 130362.58064516 0.144143254225224 0.3867 0.939 5495320.0 307000.0 0.34 6090360.0 189000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K17 compound treatment 5647560.0 -443917.41935484 -0.490844083604339 -0.2631 -0.5022 1035256 PK04_107213 C#CCNCc1ccccc1 5087480.0 -101000.0 -0.11 6046680.0 145000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K18 compound treatment 5569000.0 -522477.41935484 -0.577708688431062 -0.2715 -0.4579 3189421 PK04_107214 CC(C)[Si](Oc1ccccc1Br)(C#CCCCC#N)C(C)C 5166720.0 -21900.0 -0.02 6032240.0 131000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K19 compound treatment 5758000.0 -333477.41935484 -0.36872943292889 -0.2592 -0.5355 3071258 PK04_107215 CC(C)[C@H](N=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 5351160.0 162000.0 0.18 5644080.0 -257000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K20 compound treatment 5399320.0 -692157.41935484 -0.765325620037457 -0.6709 -0.8226 3189422 PK04_107216 CC[C@@H](O[Si](C#CCCCC#N)(C(C)C)C(C)C)C#C 4988440.0 -200000.0 -0.22 5724440.0 -177000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K21 compound treatment 5931120.0 -160357.41935484 -0.177308857730286 -1.214 -0.7254 3189423 PK04_107217 [N-]=[N+]=NC[C@H](Cc1ccccc1)NC(=O)c2ccccc2 4927560.0 -261000.0 -0.29 4267640.0 -1630000.0 -1.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K22 compound treatment 5452320.0 -639157.41935484 -0.706722971669123 -1.3866 -0.9292 3071259 PK04_107218 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#Cc4ccccc4)C(C)C 4763120.0 -426000.0 -0.47 4676760.0 -1220000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K23 mock treatment 5015120.0 -1076357.41935484 -1.19013953519055 -1.7944 -0.9625 4615800.0 -573000.0 -0.63 4615480.0 -1290000.0 -1.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 K24 mock treatment 4086320.0 -2005157.41935484 -2.21712330508694 -2.2962 -0.8793 4769920.0 -419000.0 -0.46 4604560.0 -1300000.0 -1.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L01 compound treatment 4771960.0 -1319517.41935484 -1.45900406306308 -1.8849 -0.9651 3189424 PK04_107219 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 4212600.0 -976000.0 -1.07 5167160.0 -734000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L02 compound treatment 6029520.0 -61957.4193548402 -0.0685069596275682 -0.6278 -0.8459 3189425 PK04_107220 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 4829840.0 -359000.0 -0.39 5277640.0 -624000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L03 compound treatment 6063920.0 -27557.4193548402 -0.0304705237054797 0.2691 0.6845 3071260 PK04_107221 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 5527800.0 339000.0 0.37 6025960.0 125000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L04 compound treatment 5674000.0 -417477.41935484 -0.461609102040967 -0.2308 -0.3935 3189426 PK04_107222 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 5448960.0 260000.0 0.29 5678800.0 -222000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L05 compound treatment 5992120.0 -99357.4193548402 -0.109860526589374 0.4358 0.6837 3189427 PK04_107223 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 5675480.0 487000.0 0.53 6231600.0 330000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L06 compound treatment 6170600.0 79122.5806451598 0.0874866560668576 0.4358 0.8668 3071261 PK04_107224 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 5590040.0 401000.0 0.44 6128200.0 227000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L07 mock treatment 6080880.0 -10597.4193548402 -0.0117176762276128 -0.2656 -0.7899 4912000.0 -277000.0 -0.3 5756440.0 -145000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L08 mock treatment 6212800.0 121322.58064516 0.13414763269221 -0.1552 -0.4727 4944680.0 -244000.0 -0.27 5765960.0 -135000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L09 compound treatment 5715880.0 -375597.41935484 -0.415301952726517 -0.1109 -0.1975 3189428 PK04_107225 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5512320.0 324000.0 0.35 5770520.0 -131000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L10 compound treatment 6131800.0 40322.5806451598 0.0445850946198508 0.6647 0.823 3189429 PK04_107226 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 5568080.0 379000.0 0.42 6589960.0 689000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L11 compound treatment 5622400.0 -469077.41935484 -0.518663755924099 -0.3199 -0.5565 3071262 PK04_107227 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 5013160.0 -176000.0 -0.19 6057440.0 156000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L12 compound treatment 5775640.0 -315837.41935484 -0.349224702415354 -0.0231 -0.0349 3189430 PK04_107228 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 5663400.0 475000.0 0.52 5691440.0 -210000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L13 compound treatment 6090160.0 -1317.41935484018 -0.00145668421142145 0.2102 0.7208 3189431 PK04_107229 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 5268360.0 79700.0 0.09 6178560.0 277000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L14 compound treatment 5949880.0 -141597.41935484 -0.156565731628589 -0.1739 -0.516 3071263 PK04_107230 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5303680.0 115000.0 0.13 5631600.0 -270000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L15 mock treatment 5867360.0 -224117.41935484 -0.247808949427739 -0.0583 -0.2094 5302840.0 114000.0 0.13 5923000.0 21700.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L16 mock treatment 5936640.0 -154837.41935484 -0.171205336617207 -0.4231 -0.9694 4970320.0 -218000.0 -0.24 5579960.0 -321000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L17 compound treatment 5761600.0 -329877.41935484 -0.36474887568123 0.2391 0.362 3189432 PK04_107231 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 5544560.0 356000.0 0.39 6289040.0 388000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L18 compound treatment 5955720.0 -135757.41935484 -0.150108383204607 -0.2456 -0.9349 3189547 PK04_107232 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5003160.0 -186000.0 -0.2 5829480.0 -71800.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L19 compound treatment 6528160.0 436682.58064516 0.482844447587264 0.1665 0.252 3071264 PK04_107233 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 5377120.0 188000.0 0.21 5501800.0 -399000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L20 compound treatment 6065800.0 -25677.4193548402 -0.0283917882539237 -0.6692 -0.6372 3189548 PK04_107234 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5111760.0 -76900.0 -0.08 4858560.0 -1040000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L21 compound treatment 4900480.0 -1190997.41935484 -1.3168981693216 -0.9907 -0.6731 3189549 PK04_107235 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5389600.0 201000.0 0.22 5284480.0 -617000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L22 compound treatment 5626640.0 -464837.41935484 -0.513975544054633 -1.008 -0.8874 3071265 PK04_107236 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 4960000.0 -229000.0 -0.25 4923280.0 -978000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L23 mock treatment 5391480.0 -699997.41935484 -0.773994389154584 -1.432 -0.9892 4540080.0 -649000.0 -0.71 4908880.0 -992000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 L24 mock treatment 4777840.0 -1313637.41935484 -1.45250248622524 -2.2318 -0.9959 4107040.0 -1080000.0 -1.18 4677080.0 -1220000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M01 compound treatment 4923640.0 -1167837.41935484 -1.29128991769499 -1.9228 -0.9903 3189550 PK04_107237 COc1cccc(C[C@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 4158880.0 -1030000.0 -1.13 4993200.0 -908000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M02 compound treatment 5025960.0 -1065517.41935484 -1.17815363503371 -1.652 -0.9349 3071266 PK04_107238 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCc4ccccc4)C(C)C 4784200.0 -404000.0 -0.44 4665520.0 -1240000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M03 compound treatment 5295720.0 -795757.41935484 -0.879877211942352 -0.9709 -0.9266 3189551 PK04_107239 COc1cccc(C[C@@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 4853760.0 -335000.0 -0.37 5467840.0 -433000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M04 compound treatment 5791080.0 -300397.41935484 -0.332152534664277 -0.7469 -0.881 3189552 PK04_107240 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 4996440.0 -192000.0 -0.21 5152920.0 -748000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M05 compound treatment 5208120.0 -883357.41935484 -0.976737438302089 -0.8153 -0.7887 3071267 PK04_107241 CN(C)S(=O)(=O)NCC#C 5081040.0 -108000.0 -0.12 5584800.0 -316000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M06 compound treatment 5908280.0 -183197.41935484 -0.202563282045999 -0.5943 -0.9539 3189553 PK04_107242 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](CO)Cc2ccccc2 4764000.0 -425000.0 -0.47 5540800.0 -360000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M07 compound treatment 5607160.0 -484317.41935484 -0.535514781605862 -0.5286 -0.881 3414058 PK04_107243 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 4994920.0 -194000.0 -0.21 5734080.0 -167000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M08 compound treatment 5466680.0 -624797.41935484 -0.690844971092344 -0.8089 -0.7824 3189554 PK04_107244 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(Cc2cccc(Cl)c2)nn1 5240640.0 52000.0 0.06 5136960.0 -764000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M09 mock treatment 5624680.0 -466797.41935484 -0.516142736333915 -0.6024 -0.945 4967800.0 -221000.0 -0.24 5617000.0 -284000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M10 mock treatment 6196440.0 104962.58064516 0.116058211422287 -0.3844 -0.6317 4977720.0 -211000.0 -0.23 5352360.0 -549000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M11 compound treatment 6312400.0 220922.58064516 0.244276383210815 0.2961 0.6681 3189555 PK04_107245 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 5516240.0 328000.0 0.36 5811520.0 -89800.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M12 compound treatment 6222960.0 131482.58064516 0.145381649813385 0.0488 0.2912 3071269 PK04_107246 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](C)c2ccccc2 5207160.0 18500.0 0.02 5820520.0 -80800.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M13 mock treatment 5937800.0 -153677.41935484 -0.169922712615183 0.4433 0.63 5511640.0 323000.0 0.35 6483280.0 582000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M14 mock treatment 5774000.0 -317477.41935484 -0.351038067383733 -0.209 -0.5568 5269480.0 80800.0 0.09 5802120.0 -99200.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M15 compound treatment 5460160.0 -631317.41935484 -0.698054202551996 -0.4351 -0.5552 3189556 PK04_107247 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 5391800.0 203000.0 0.22 5624280.0 -277000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M16 compound treatment 6190320.0 98842.5806451598 0.109291264101264 -0.3584 -0.4394 3189557 PK04_107248 CCCC#C[Si](O[C@H](CC)c1cn(Cc2ccccc2)nn1)(C(C)C)C(C)C 5256880.0 68200.0 0.07 5099480.0 -802000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M17 compound treatment 5717360.0 -374117.41935484 -0.41366550141359 -0.2862 -0.5323 3189558 PK04_107249 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H](Cc5ccccc5)NC2=O 5369800.0 181000.0 0.2 5621880.0 -279000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M18 compound treatment 5529600.0 -561877.41935484 -0.621273676086013 -1.1101 -0.9984 3071329 PK04_107250 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C(C)C)C(C)C 4632640.0 -556000.0 -0.61 5211240.0 -690000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M19 compound treatment 5672360.0 -419117.41935484 -0.463422467009345 -0.6068 -0.9457 3189559 PK04_107251 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H]5CCCN5C2=O 5021160.0 -168000.0 -0.18 5498640.0 -403000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M20 compound treatment 5724440.0 -367037.41935484 -0.405837072159858 -0.7241 -0.9363 3071330 PK04_107252 CCCC#C[Si](O[C@H](CC)c1cn(Cc2cccc(Cl)c2)nn1)(C(C)C)C(C)C 4976440.0 -212000.0 -0.23 5287520.0 -614000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M21 compound treatment 5106520.0 -984957.41935484 -1.08907760951384 -1.1686 -0.9024 3189560 PK04_107253 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H]5CCCN5C2=O)nn4 4911280.0 -277000.0 -0.3 5272400.0 -629000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M22 compound treatment 4954400.0 -1137077.41935484 -1.25727826743442 -1.7497 -0.9544 3071331 PK04_107254 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](C)c2ccccc2)(C(C)C)C(C)C 4673480.0 -515000.0 -0.56 4696480.0 -1200000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M23 compound treatment 5329640.0 -761837.41935484 -0.842371516986618 -1.6114 -0.9929 3189561 PK04_107255 CN1Cc2cn(C[C@H](Cc3ccccc3)NC(=O)c4cc(c(CC[C@@H](CO)NC1=O)o4)S(=O)(=O)c5ccc(C)cc5)nn2 4195800.0 -993000.0 -1.09 5043080.0 -858000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 M24 compound treatment 4591480.0 -1499997.41935484 -1.65856266641246 -2.7075 -0.9991 3071332 PK04_107256 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C(C)C)C(C)C 3813640.0 -1380000.0 -1.51 4381640.0 -1520000.0 -1.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N01 compound treatment 6150080.0 58602.5806451598 0.0647974797551932 -1.3182 -0.7875 3189562 PK04_107257 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 4247440.0 -941000.0 -1.03 4588800.0 -1310000.0 -1.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N02 compound treatment 5165240.0 -926237.41935484 -1.02415029796311 -0.9575 -0.597 3189563 PK04_107258 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5641640.0 453000.0 0.5 4775040.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N03 compound treatment 5328040.0 -763437.41935484 -0.844140653541134 -0.1747 -0.0894 3071333 PK04_107259 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 4325360.0 -863000.0 -0.95 7383000.0 1480000.0 1.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N04 compound treatment 5250600.0 -840877.41935484 -0.929766862779696 -0.9105 -0.6898 3189564 PK04_107260 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5420920.0 232000.0 0.25 5002880.0 -898000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N05 compound treatment 5608440.0 -483037.41935484 -0.534099472362249 -0.5784 -0.6886 3189681 PK04_107261 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 5335120.0 146000.0 0.16 5275480.0 -626000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N06 compound treatment 5662160.0 -429317.41935484 -0.474700712544383 0.3627 0.396 3071334 PK04_107262 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 5644200.0 456000.0 0.5 6503200.0 602000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N07 compound treatment 5525840.0 -565637.41935484 -0.625431146989125 -0.903 -0.9349 3189682 PK04_107263 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 4554760.0 -634000.0 -0.69 5657760.0 -244000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N08 compound treatment 6384880.0 293402.58064516 0.324418269130379 -0.5216 -0.5605 3071335 PK04_107264 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 4574760.0 -614000.0 -0.67 5347760.0 -554000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N09 mock treatment 5441600.0 -649877.41935484 -0.718576186584379 -0.7044 -0.8594 5071080.0 -118000.0 -0.13 5529840.0 -371000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N10 mock treatment 5689760.0 -401717.41935484 -0.444183106978987 -0.4575 -0.8977 5002360.0 -186000.0 -0.2 5757640.0 -144000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N11 compound treatment 6230040.0 138562.58064516 0.153210079067118 -0.3119 -0.5312 3189683 PK04_107265 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5055680.0 -133000.0 -0.15 5355440.0 -546000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N12 compound treatment 5530240.0 -561237.41935484 -0.620566021464206 -0.5289 -0.6005 3189684 PK04_107266 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5434120.0 245000.0 0.27 5339040.0 -562000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N13 mock treatment 6594200.0 502722.58064516 0.555865558874901 -0.0037 -0.0052 5068320.0 -120000.0 -0.13 5472320.0 -429000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N14 mock treatment 5648720.0 -442757.41935484 -0.489561459602315 -0.6469 -0.963 4972960.0 -216000.0 -0.24 5508000.0 -393000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N15 compound treatment 5838760.0 -252717.41935484 -0.279432265339708 -0.738 -0.7253 3071336 PK04_107267 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 5169800.0 -18900.0 -0.02 4926600.0 -975000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N16 compound treatment 5793920.0 -297557.41935484 -0.329012317280012 -0.0483 -0.0721 3189685 PK04_107268 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5660640.0 472000.0 0.52 5630760.0 -271000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N17 compound treatment 6169840.0 78362.5806451598 0.0866463162034626 -0.6103 -0.7344 3189686 PK04_107269 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 4556240.0 -632000.0 -0.69 5451680.0 -450000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N18 compound treatment 5712920.0 -378557.41935484 -0.418574855352371 -0.5221 -0.9497 3071337 PK04_107270 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 4905320.0 -283000.0 -0.31 5726400.0 -175000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N19 compound treatment 5746280.0 -345197.41935484 -0.381688358190718 -0.5303 -0.8519 3189687 PK04_107271 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 5145360.0 -43300.0 -0.05 5413560.0 -488000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N20 compound treatment 5486120.0 -605357.41935484 -0.669349961954978 -1.4163 -0.974 3189688 PK04_107272 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 4551560.0 -637000.0 -0.7 4819080.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N21 compound treatment 5875760.0 -215717.41935484 -0.238520982516531 -0.0486 -0.0395 3071339 PK04_107273 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 6035280.0 847000.0 0.93 5131280.0 -770000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N22 compound treatment 5267760.0 -823717.41935484 -0.910792873232514 -1.7222 -0.9947 3189689 PK04_107274 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 4336440.0 -852000.0 -0.93 4766480.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N23 compound treatment 4823960.0 -1267517.41935484 -1.40150712504132 -1.8438 -0.9732 3189690 PK04_107275 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 4459960.0 -729000.0 -0.8 4910800.0 -990000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 N24 compound treatment 4683320.0 -1408157.41935484 -1.55701422818325 -2.6645 -0.9826 3071341 PK04_107276 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 4116880.0 -1070000.0 -1.17 4023720.0 -1880000.0 -1.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O01 compound treatment 4130840.0 -1960637.41935484 -2.16789708045754 -3.1771 -0.9907 3414059 PK04_107277 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(Cc5ccccc5)C2=O)nn4 3765960.0 -1420000.0 -1.56 4130640.0 -1770000.0 -1.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O02 compound treatment 4459520.0 -1631957.41935484 -1.80447220374614 -2.4289 -0.9782 3189692 PK04_107278 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C(C)C)C(C)C 4189360.0 -999000.0 -1.09 4597840.0 -1300000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O03 compound treatment 5196080.0 -895397.41935484 -0.99005019087482 -1.2872 -0.929 3414060 PK04_107279 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(nn4)C5(CCCCC5)NC2=O 4890160.0 -299000.0 -0.33 4991960.0 -909000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O04 compound treatment 4884640.0 -1206837.41935484 -1.33441262121131 -1.8881 -0.9704 3189693 PK04_107280 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C(C)C)C(C)C 4539000.0 -650000.0 -0.71 4681240.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O05 compound treatment 5496280.0 -595197.41935484 -0.658115944833803 -1.8662 -0.9542 3071393 PK04_107281 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cnnn3C[C@H](Cc4ccccc4)NC2=O 4194680.0 -994000.0 -1.09 4420880.0 -1480000.0 -1.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O06 compound treatment 4956680.0 -1134797.41935484 -1.25475724784424 -1.8298 -0.9825 3189694 PK04_107282 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C(C)C)C(C)C 4474640.0 -714000.0 -0.78 4772640.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O07 compound treatment 5559160.0 -532317.41935484 -0.588588878241334 -0.8268 -0.8331 3189695 PK04_107283 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 5146960.0 -41700.0 -0.05 5106360.0 -795000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O08 compound treatment 5591160.0 -500317.41935484 -0.553206147151019 -1.2722 -0.9543 3071395 PK04_107284 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 4648840.0 -540000.0 -0.59 4846000.0 -1060000.0 -1.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O09 compound treatment 4754520.0 -1336957.41935484 -1.4782876515073 -1.1288 -0.7362 3189696 PK04_107285 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 4823560.0 -365000.0 -0.4 5824520.0 -76800.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O10 compound treatment 5126440.0 -965037.41935484 -1.06705185941012 -0.949 -0.8255 3189697 PK04_107286 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 5008720.0 -180000.0 -0.2 5523000.0 -378000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O11 mock treatment 5315000.0 -776477.41935484 -0.858559116460437 -0.753 -0.8063 5107160.0 -81500.0 -0.09 5546160.0 -355000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O12 mock treatment 5589080.0 -502397.41935484 -0.55550602467189 -0.4085 -0.6938 5224440.0 35800.0 0.04 5710680.0 -191000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O13 compound treatment 6166800.0 75322.5806451598 0.0832849567498827 -0.7223 -0.7014 3071396 PK04_107287 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](C)NC2=O)nn4 4840280.0 -348000.0 -0.38 4951800.0 -949000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O14 compound treatment 5415880.0 -675597.41935484 -0.747015056698219 -0.7694 -0.8313 3187592 PK04_107288 CC(C)[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 5151560.0 -37100.0 -0.04 5358200.0 -543000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O15 compound treatment 5097920.0 -993557.41935484 -1.09858671849436 -1.035 -0.8601 3187593 PK04_107289 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](Cc5ccccc5)NC2=O 4859240.0 -329000.0 -0.36 5569160.0 -332000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O16 compound treatment 5114760.0 -976717.41935484 -1.07996655625808 -0.8339 -0.7339 3071397 PK04_107290 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 5178480.0 -10200.0 -0.01 5549280.0 -352000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O17 compound treatment 5487640.0 -603837.41935484 -0.667669282228188 -0.9925 -0.9917 3187594 PK04_107291 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 4672440.0 -516000.0 -0.57 5417040.0 -484000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O18 compound treatment 5224520.0 -866957.41935484 -0.958603788618302 -1.274 -0.9767 3071398 PK04_107292 CC(C)[Si](O[C@H](C)c1cn(Cc2ccccc2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 4658120.0 -531000.0 -0.58 5236600.0 -665000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O19 compound treatment 5680440.0 -411037.41935484 -0.454488327409041 -1.0162 -0.9874 3187595 PK04_107293 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](NC2=O)C(C)C)nn4 4581640.0 -607000.0 -0.66 5262640.0 -639000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O20 compound treatment 5224320.0 -867157.41935484 -0.958824930687617 -1.5629 -0.966 3071399 PK04_107294 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 4656880.0 -532000.0 -0.58 4739680.0 -1160000.0 -1.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O21 compound treatment 5217280.0 -874197.41935484 -0.966609131527486 -1.3393 -0.9219 3187594 PK04_107295 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 4900520.0 -288000.0 -0.32 4867480.0 -1030000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O22 compound treatment 4674280.0 -1417197.41935484 -1.56700984971627 -2.6907 -0.9867 3187596 PK04_107296 CC(C)[Si](O[C@H](C)c1cn(Cc2cccc(Cl)c2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 3490080.0 -1700000.0 -1.86 4672400.0 -1230000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O23 compound treatment 4709360.0 -1382117.41935484 -1.52822153075851 -2.2625 -0.9792 3187597 PK04_107297 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](NC2=O)C(C)C 4344040.0 -845000.0 -0.92 4441000.0 -1460000.0 -1.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 O24 compound treatment 4316760.0 -1774717.41935484 -1.96232341282281 -2.9261 -0.9797 3071400 PK04_107298 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](C)c2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 4091320.0 -1100000.0 -1.2 4003960.0 -1900000.0 -1.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P01 compound treatment 4548400.0 -1543077.41935484 -1.70619666814279 -3.1667 -0.9919 3187598 PK04_107299 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 3707040.0 -1480000.0 -1.62 3752760.0 -2150000.0 -2.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P02 compound treatment 4591640.0 -1499837.41935484 -1.65838575275701 -2.4704 -0.9817 3071401 PK04_107300 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 4241480.0 -947000.0 -1.04 4323680.0 -1580000.0 -1.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P03 compound treatment 4863760.0 -1227717.41935484 -1.35749985324774 -2.6118 -0.948 3187599 PK04_107301 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 4296520.0 -892000.0 -0.98 3719840.0 -2180000.0 -2.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P04 compound treatment 5022480.0 -1068997.41935484 -1.18200150703978 -2.1045 -0.995 3187600 PK04_107302 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 4197320.0 -991000.0 -1.09 4528760.0 -1370000.0 -1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P05 compound treatment 4661600.0 -1429877.41935484 -1.5810302569108 -2.1122 -0.9746 3071402 PK04_107303 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 4111400.0 -1080000.0 -1.18 5006840.0 -894000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P06 compound treatment 5235800.0 -855677.41935484 -0.946131375908966 -1.626 -0.999 3187601 PK04_107304 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 4288080.0 -901000.0 -0.99 5020440.0 -881000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P07 compound treatment 4834920.0 -1256557.41935484 -1.38938853964289 -2.1054 -0.993 3187602 PK04_107305 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 4244240.0 -944000.0 -1.03 4682720.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P08 compound treatment 5087640.0 -1003837.41935484 -1.10995342085712 -1.572 -0.9878 3071403 PK04_107306 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 4444520.0 -744000.0 -0.81 5106200.0 -795000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P09 compound treatment 4673040.0 -1418437.41935484 -1.56838093054602 -2.4283 -0.9944 3187603 PK04_107307 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 4086880.0 -1100000.0 -1.21 4475400.0 -1430000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P10 compound treatment 6154160.0 62682.5806451598 0.0693087779692083 -0.9045 -0.7772 3187604 PK04_107308 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 4372600.0 -816000.0 -0.89 5161680.0 -740000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P11 mock treatment 5220920.0 -870557.41935484 -0.962584345865963 -1.8476 -0.9971 4129800.0 -1060000.0 -1.16 4827160.0 -1070000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P12 mock treatment 5613600.0 -477877.41935484 -0.528394006973936 -1.5831 -0.9413 4381560.0 -807000.0 -0.88 4576280.0 -1330000.0 -1.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P13 compound treatment 4442160.0 -1649317.41935484 -1.82366733536264 -2.4964 -0.9807 3071404 PK04_107309 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 4155560.0 -1030000.0 -1.13 4537240.0 -1360000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P14 compound treatment 4579360.0 -1512117.41935484 -1.67196387581291 -2.1695 -0.973 3187605 PK04_107310 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 4215760.0 -973000.0 -1.07 4884600.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P15 compound treatment 5048480.0 -1042997.41935484 -1.1532530380289 -1.9477 -0.9823 3187606 PK04_107311 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 4413600.0 -775000.0 -0.85 4534760.0 -1370000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P16 compound treatment 2137520.0 -3953957.41935484 -4.37193162848712 -4.3503 -0.878 3071405 PK04_107312 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 4171200.0 -1020000.0 -1.11 3859760.0 -2040000.0 -2.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P17 compound treatment 4366080.0 -1725397.41935484 -1.90778977852986 -2.5126 -0.975 3187607 PK04_107313 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 3996640.0 -1190000.0 -1.31 4766520.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P18 compound treatment 4842960.0 -1248517.41935484 -1.38049862845644 -2.2502 -0.998 3187608 PK04_107314 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 4103840.0 -1080000.0 -1.19 4577120.0 -1320000.0 -1.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P19 compound treatment 4227920.0 -1863557.41935484 -2.0605547200123 -2.4679 -0.9535 3187728 PK04_107315 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 4204640.0 -984000.0 -1.08 4768960.0 -1130000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P20 compound treatment 4571760.0 -1519717.41935484 -1.68036727444686 -3.0252 -0.9937 3071452 PK04_107316 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 3776920.0 -1410000.0 -1.55 3895040.0 -2010000.0 -2.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P21 compound treatment 4566080.0 -1525397.41935484 -1.68664770921539 -2.4299 -0.9883 3187729 PK04_107317 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 3946760.0 -1240000.0 -1.36 4743320.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P22 compound treatment 4177360.0 -1914117.41935484 -2.11645943513499 -2.968 -0.9824 3187730 PK04_107318 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 3985480.0 -1200000.0 -1.32 4200800.0 -1700000.0 -1.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P23 compound treatment 4140160.0 -1951317.41935484 -2.15759186002749 -3.1558 -0.9815 3071453 PK04_107319 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 3973720.0 -1210000.0 -1.33 3930360.0 -1970000.0 -1.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2107 P24 compound treatment 3437480.0 -2653997.41935484 -2.93455240635694 -3.9469 -0.9735 3187731 PK04_107320 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 3706600.0 -1480000.0 -1.62 3630720.0 -2270000.0 -2.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A01 compound treatment 3987200.0 -1134165.71428571 -1.25405876501332 -2.6565 -0.9811 3187732 PK04_108001 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 4035480.0 -1780000.0 -1.95 4131080.0 -1390000.0 -1.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A02 compound treatment 4510160.0 -611205.71428571 -0.675816482169847 -1.5574 -0.9848 3071454 PK04_108002 CCC1=C2CN(Cc3ccccc3Br)[C@@H]([C@@H](O)Cc4ccccc4)C2C=CCC1 4914040.0 -906000.0 -0.99 4493040.0 -1030000.0 -1.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A03 compound treatment 4737720.0 -383645.71428571 -0.424201035703845 -0.8277 -0.9291 3187733 PK04_108003 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5567320.0 -252000.0 -0.28 4788840.0 -730000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A04 compound treatment 4832160.0 -289205.71428571 -0.319777750573554 -0.9899 -0.9311 3071455 PK04_108004 CCC1=C2CN(Cc3ccccc3)[C@H](C2C=CCC1)C(=O)Cc4ccccc4 5031160.0 -789000.0 -0.86 4990040.0 -529000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A05 compound treatment 4762280.0 -359085.71428571 -0.397044789592029 -0.7382 -0.9464 3187734 PK04_108005 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 5256160.0 -564000.0 -0.62 5255800.0 -263000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A06 compound treatment 4875560.0 -245805.71428571 -0.271789921532314 -0.6539 -0.9781 3071456 PK04_108006 C/C=C\[C@@H](NCc1ccccc1Br)[C@@H](O)Cc2ccccc2 5459480.0 -360000.0 -0.39 5054600.0 -465000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A07 compound treatment 4738040.0 -383325.71428571 -0.423847208392942 -0.8507 -0.9593 3187735 PK04_108007 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5187960.0 -632000.0 -0.69 5162840.0 -356000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A08 compound treatment 5118320.0 -3045.7142857099 -0.00336767779841262 -0.6371 -0.7906 3071457 PK04_108008 CC(=CCN[C@H](CO)c1ccccc1)C 5181680.0 -638000.0 -0.7 5119360.0 -400000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A09 compound treatment 5137360.0 15994.2857142901 0.0176850472003247 -0.4018 -0.7857 3187736 PK04_108009 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5546280.0 -273000.0 -0.3 5106600.0 -413000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A10 compound treatment 5166360.0 44994.2857142901 0.0497506472509226 -0.4384 -0.7154 3071458 PK04_108010 CC(=CCN(CC#C)[C@H](CO)c1ccccc1)C 5312240.0 -508000.0 -0.56 5266800.0 -252000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A11 compound treatment 5322920.0 201554.28571429 0.222860659110288 -0.2609 -0.4772 3071459 PK04_108011 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5606560.0 -213000.0 -0.23 5079520.0 -440000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A12 compound treatment 4110200.0 -1011165.71428571 -1.11805639238492 -3.1701 -0.9389 3187737 PK04_108012 CC(=CCN(CC#Cc1ccccc1)[C@H](CO)c2ccccc2)C 3327920.0 -2490000.0 -2.73 3881280.0 -1640000.0 -1.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A13 mock treatment 4134640.0 -986725.71428571 -1.09103283151469 -1.4042 -0.9531 5023520.0 -796000.0 -0.87 5051800.0 -467000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A14 mock treatment 5265120.0 143754.28571429 0.158950601078407 -0.2614 -0.5459 5624520.0 -195000.0 -0.21 5122840.0 -396000.0 -0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A15 compound treatment 4946680.0 -174685.71428571 -0.193151801684089 -0.4695 -0.8354 3187738 PK04_108013 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5347040.0 -473000.0 -0.52 5417320.0 -102000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A16 compound treatment 5160520.0 39154.2857142901 0.0432932988269401 -0.4853 -0.6259 3071460 PK04_108014 O=C1OC[C@@H](c2ccccc2)n3cc(/C=C/c4ccccc4)cc13 5121200.0 -699000.0 -0.77 5400760.0 -118000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A17 compound treatment 4930400.0 -190965.71428571 -0.211152766126287 -0.8929 -0.8421 3187739 PK04_108015 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 4930000.0 -890000.0 -0.97 5159440.0 -360000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A18 compound treatment 4961120.0 -160245.71428571 -0.177185344279585 -0.9446 -0.8709 3071461 PK04_108016 CC(=C)C/1CN([C@H](CO)c2ccccc2)C(=O)\C1=C/c3ccccc3 4970000.0 -850000.0 -0.93 4992720.0 -527000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A19 compound treatment 4811480.0 -309885.71428571 -0.34264384054067 -0.878 -0.948 3187740 PK04_108017 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5142840.0 -677000.0 -0.74 5084080.0 -435000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A20 compound treatment 4751560.0 -369805.71428571 -0.408898004507284 -0.8548 -0.8727 3071462 PK04_108018 OCC(/C=C/c1ccccc1)N(CC#C)C(C(=O)O)c2ccccc2 5028920.0 -791000.0 -0.87 5314320.0 -205000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A21 compound treatment 4506040.0 -615325.71428571 -0.680372008797725 -1.6445 -0.9697 3187741 PK04_108019 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 4668000.0 -1150000.0 -1.26 4615880.0 -903000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A22 compound treatment 4205840.0 -915525.71428571 -1.01230625483874 -1.8903 -0.9963 3071463 PK04_108020 C/C=C/CN([C@H](CO[Si](C)(C)C(C)(C)C)c1ccccc1)C(=O)C#Cc2ccccc2 4872280.0 -947000.0 -1.04 4299440.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A23 compound treatment 4505480.0 -615885.71428571 -0.680991206591806 -1.5094 -0.9766 3187742 PK04_108021 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 4783880.0 -1040000.0 -1.13 4723200.0 -796000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 A24 compound treatment 4759080.0 -362285.71428571 -0.40058306270106 -1.5977 -0.9167 3071464 PK04_108022 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 4560720.0 -1260000.0 -1.38 4534920.0 -984000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B01 compound treatment 5045840.0 -75525.7142857099 -0.0835095637179759 -1.0009 -0.8387 2133065 PK04_108023 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(C3CCCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 4913680.0 -906000.0 -0.99 4863680.0 -656000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B02 compound treatment 4997920.0 -123445.71428571 -0.136495203525722 -0.9036 -0.8788 3071465 PK04_108024 CCCCNC(=O)c1ccc(C#CC(C)(C)C)c(OC(=O)C)c1 5254520.0 -565000.0 -0.62 4712600.0 -807000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B03 compound treatment 5435720.0 314354.28571429 0.347584786203648 -0.0589 -0.1119 2133224 PK04_108025 CCCCC(=O)N(Cc1ccccc1F)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 5463520.0 -356000.0 -0.39 5460040.0 -59200.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B04 compound treatment 5447560.0 326194.28571429 0.360676396707065 0.0364 0.0658 1952196 PK04_108026 CCCCNC(=O)c1ccc(C#C[Si](C)(C)C)c(OC(=O)C)c1 5450480.0 -369000.0 -0.4 5625560.0 106000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B05 compound treatment 5422840.0 301474.28571429 0.333343236939797 -0.0561 -0.1178 2133510 PK04_108027 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCc3cccc(F)c3)C(=O)CCC4CCCC4)C(=O)NCCO 5720880.0 -98900.0 -0.11 5198200.0 -321000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B06 compound treatment 5167920.0 46554.2857142901 0.0514755553915755 0.1449 0.9497 3071510 PK04_108028 CCCCNC(=O)c1ccc(C#C[Si](C(C)C)(C(C)C)C(C)C)c(OC(=O)C)c1 5928280.0 109000.0 0.12 5599560.0 80300.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B07 compound treatment 5495240.0 373874.28571429 0.413396666031634 0.1065 0.2237 2128988 PK04_108029 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H]3O[C@@H]32)C(=O)NCCO 5604480.0 -215000.0 -0.24 5526000.0 6760.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B08 compound treatment 5536440.0 415074.28571429 0.458951932310414 0.1293 0.192 3187870 PK04_108030 COC(=O)C[C@H]1O[C@@H](CCc2ccccc2)[C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3 5413040.0 -407000.0 -0.45 5728880.0 210000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B09 compound treatment 5788840.0 667474.28571429 0.738033223785273 0.654 0.7812 3187871 PK04_108031 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)N(Cc3ccco3)C(=O)Cc4ccccc4 5819360.0 -399.0 0.0 5913000.0 394000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B10 compound treatment 5650360.0 528994.28571429 0.584914454991935 1.2605 0.9851 3071511 PK04_108032 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(I)cc52 6635440.0 816000.0 0.89 6221720.0 702000.0 0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B11 compound treatment 5302520.0 181154.28571429 0.200304168040213 0.4337 0.9873 2129008 PK04_108033 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)NCc3ccc(F)cc3 6049920.0 230000.0 0.25 5816960.0 298000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B12 compound treatment 5602080.0 480714.28571429 0.531530759459423 0.5201 0.8445 3187872 PK04_108034 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc52 5879280.0 59500.0 0.07 5822240.0 303000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B13 mock treatment 4623480.0 -497885.71428571 -0.55051738569627 -0.1913 -0.328 5846080.0 26300.0 0.03 5708960.0 190000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B14 mock treatment 5978920.0 857554.28571429 0.948206646461744 0.6208 0.6513 5901600.0 81800.0 0.09 5556520.0 37300.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B15 compound treatment 5864960.0 743594.28571429 0.82219989536636 0.6663 0.7095 3187873 PK04_108035 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CCC\C=C\CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 5720440.0 -99300.0 -0.11 5958360.0 439000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B16 compound treatment 5487560.0 366194.28571429 0.404904810569958 0.7753 0.9284 3414061 PK04_108036 COC(=O)C[C@@H]1C[C@H](C)[C@]2(O1)C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42 6445480.0 626000.0 0.69 5771080.0 252000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B17 compound treatment 4964080.0 -157285.71428571 -0.17391244165373 -0.2015 -0.8795 3187874 PK04_108037 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CCC\C=C\CNC(=O)[C@@H](Cc5ccccc5)NC(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 5686120.0 -134000.0 -0.15 5490600.0 -28600.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B18 compound treatment 5317160.0 195794.28571429 0.216491767514032 0.0665 0.2915 3071513 PK04_108038 CC(C)[Si](OCC[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)O)C(=O)N(Cc3ccccc3)c4ccccc42)(C(C)C)C(C)C 5771320.0 -48400.0 -0.05 5471120.0 -48100.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B19 compound treatment 5430760.0 309394.28571429 0.342100462884649 0.2116 0.6124 3187875 PK04_108039 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CCC\C=C\CNC(=O)[C@@H]5CCCN5C(=O)CNC4=O)[C@@H]6O[C@@]61C 5860120.0 40400.0 0.04 5499480.0 -19800.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B20 compound treatment 5407560.0 286194.28571429 0.316447982844171 0.2615 0.6589 3071514 PK04_108040 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccccc53 6023680.0 204000.0 0.22 5432760.0 -86500.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B21 compound treatment 5092000.0 -29365.7142857099 -0.0324699741201966 -0.6789 -0.8339 3187876 PK04_108041 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/CC\C=C\CNC(=O)[C@@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 5240000.0 -580000.0 -0.63 5012520.0 -507000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B22 compound treatment 4742600.0 -378765.71428571 -0.418805169212572 -0.8242 -0.9863 3071515 PK04_108042 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(C)cc3)C(=O)N(C)c4ccccc42 5282360.0 -537000.0 -0.59 5100520.0 -419000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B23 compound treatment 4723160.0 -398205.71428571 -0.440300178349939 -1.0443 -0.98 3187877 PK04_108043 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC(=O)[C@@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 5241840.0 -578000.0 -0.63 4786320.0 -733000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 B24 compound treatment 4278920.0 -842445.71428571 -0.931500942711235 -1.8648 -0.9943 3071516 PK04_108044 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(C)c4ccccc42 4711960.0 -1110000.0 -1.21 4437840.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C01 compound treatment 4126840.0 -994525.71428571 -1.09965737221796 -1.3326 -0.9508 3187878 PK04_108045 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 5370240.0 -450000.0 -0.49 4805560.0 -714000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C02 compound treatment 4804520.0 -316845.71428571 -0.350339584552813 -0.6699 -0.8538 3071464 PK04_108046 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 5187760.0 -632000.0 -0.69 5401840.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C03 compound treatment 5629920.0 508554.28571429 0.562313735507997 0.4758 0.7154 3187879 PK04_108047 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 5743640.0 -76100.0 -0.08 5863080.0 344000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C04 compound treatment 5631280.0 509914.28571429 0.563817501579335 0.8282 0.9783 3071517 PK04_108048 CC(=C)C1C(=C)CN([C@H](CO)c2ccccc2)C1=O 6126560.0 307000.0 0.34 6052080.0 533000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C05 compound treatment 5537600.0 416234.28571429 0.460234556312438 0.7057 0.9798 3071518 PK04_108049 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 6250760.0 431000.0 0.47 5808240.0 289000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C06 compound treatment 5426480.0 305114.28571429 0.33736802260132 0.8278 0.9757 3187880 PK04_108050 CC(C)(C)OC(=O)N(CC#C)[C@H](CO)c1ccccc1 6365560.0 546000.0 0.6 6016240.0 497000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C07 compound treatment 5539480.0 418114.28571429 0.462313291763994 0.5353 0.9435 3187881 PK04_108051 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 6025400.0 206000.0 0.23 5758000.0 239000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C08 compound treatment 4546840.0 -574525.71428571 -0.635259026657574 -3.5478 -0.8985 3071519 PK04_108052 CC(=CCN([C@H](CO)c1ccccc1)C(=O)C#Cc2ccccc2)C 3242560.0 -2580000.0 -2.82 2841520.0 -2680000.0 -2.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C09 compound treatment 5439240.0 317874.28571429 0.351476886623583 0.4247 0.7306 3187882 PK04_108053 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 5753040.0 -66700.0 -0.07 5974800.0 456000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C10 compound treatment 5380440.0 259074.28571429 0.286461118245129 -1.2713 -0.6816 3071520 PK04_108054 OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 5037760.0 -782000.0 -0.86 3893040.0 -1630000.0 -1.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C11 mock treatment 5221920.0 100554.28571429 0.111183914106482 0.4303 0.5117 5655560.0 -164000.0 -0.18 6330200.0 811000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C12 mock treatment 6056560.0 935194.28571429 1.03405399776962 1.4685 0.9599 6274560.0 455000.0 0.5 6526960.0 1010000.0 1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C13 compound treatment 5675040.0 553674.28571429 0.612203386345341 0.7692 0.9659 3187883 PK04_108055 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 6155720.0 336000.0 0.37 5870200.0 351000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C14 compound treatment 5724200.0 602834.28571429 0.666560106982837 0.9257 0.9848 3071521 PK04_108056 CC(C)(C)[Si](C)(C)OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 6234320.0 415000.0 0.45 6000320.0 481000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C15 mock treatment 5435520.0 314154.28571429 0.347363644134334 0.4892 0.9438 5950000.0 130000.0 0.14 5875280.0 356000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C16 mock treatment 5378440.0 257074.28571429 0.284249697551985 0.4183 0.7959 5818160.0 -1600.0 0.0 5959760.0 441000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C17 compound treatment 5694640.0 573274.28571429 0.633875309138159 0.803 0.9674 3188001 PK04_108057 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 6182320.0 363000.0 0.4 5877920.0 359000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C18 compound treatment 5368960.0 247594.28571429 0.273767563466479 0.1364 0.3244 3071522 PK04_108058 O=C1OC[C@H](N2CC(=CC21)/C=C/c3ccccc3)c4ccccc4 5597360.0 -222000.0 -0.24 5724480.0 205000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C19 compound treatment 5639000.0 517634.28571429 0.572353585454874 0.7573 0.873 3188002 PK04_108059 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5905960.0 86200.0 0.09 6161920.0 643000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C20 compound treatment 5607040.0 485674.28571429 0.537015082778422 -0.3526 -0.3469 3071523 PK04_108060 OCC(/C=C/c1ccccc1)N(CC#C)Cc2ccccc2Br 5485120.0 -335000.0 -0.37 4740760.0 -778000.0 -0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C21 compound treatment 5688560.0 567194.28571429 0.627152590230999 0.3269 0.5091 3188003 PK04_108061 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5876680.0 56900.0 0.06 5396440.0 -123000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C22 compound treatment 5448360.0 326994.28571429 0.361560964984323 0.0046 0.0104 3071524 PK04_108062 OCC1C=C(CN1Cc2ccccc2Br)/C=C/c3ccccc3 5624960.0 -195000.0 -0.21 5379480.0 -140000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C23 compound treatment 4775280.0 -346085.71428571 -0.382670555086588 -0.4016 -0.7028 3188004 PK04_108063 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5443000.0 -377000.0 -0.41 5618520.0 99300.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 C24 compound treatment 4706680.0 -414685.71428571 -0.458522284861451 -1.4053 -0.9552 3071525 PK04_108064 CCOC(=O)C1OC[C@H](N1CC#C)c2ccccc2 4883720.0 -936000.0 -1.03 4572160.0 -947000.0 -0.95 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D01 compound treatment 4384480.0 -736885.71428571 -0.814782158527059 -2.4758 -0.952 3188005 PK04_108065 CC(C)C[C@@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 4067200.0 -1750000.0 -1.92 3970640.0 -1550000.0 -1.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D02 compound treatment 4468080.0 -653285.71428571 -0.722344773553611 -1.4941 -0.9767 3414062 PK04_108066 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccccc3)C(=O)N(C)c4ccccc42 4787480.0 -1030000.0 -1.13 4786800.0 -732000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D03 compound treatment 5352040.0 230674.28571429 0.255058944402475 -1.264 -0.6046 3188006 PK04_108067 CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 3962320.0 -1860000.0 -2.03 5110400.0 -409000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D04 compound treatment 5255760.0 134394.28571429 0.14860115223449 0.1862 0.3015 3071527 PK04_108068 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 5520280.0 -299000.0 -0.33 6019320.0 500000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D05 compound treatment 5304680.0 183314.28571429 0.202692502388809 0.0715 0.3041 3188007 PK04_108069 CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)C(C)C 5715680.0 -104000.0 -0.11 5554280.0 35000.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D06 compound treatment 5615760.0 494394.28571429 0.546656877000532 0.5518 0.7995 3071528 PK04_108070 CCOC(=O)[C@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@@H]2O[Si](C)(C)C(C)(C)C 5808760.0 -11000.0 -0.01 5938800.0 420000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D07 compound treatment 4903280.0 -218085.71428571 -0.241139630725329 0.1312 0.2996 3188008 PK04_108071 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CC\C=C\CNC(=O)[C@@H]5CCCN5C(=O)[C@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 6133320.0 314000.0 0.34 5643720.0 124000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D08 compound treatment 5238320.0 116954.28571429 0.129317563790268 0.8918 0.8832 3071529 PK04_108072 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 6488040.0 668000.0 0.73 6200280.0 681000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D09 compound treatment 5315400.0 194034.28571429 0.214545717304064 0.5954 0.9042 3188009 PK04_108073 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)CNC2=O)[C@@H]6O[C@]6(C)[C@H]4C 6342840.0 523000.0 0.57 5762280.0 243000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D10 compound treatment 5651440.0 530074.28571429 0.586108622166233 0.7873 0.8126 3071530 PK04_108074 CCOC(=O)[C@H]1C[C@H]2O[C@]32C[C@H]1C(=O)N4CCCC4[C@@H]3O[Si](C)(C)C(C)(C)C 5825320.0 5560.0 0.01 6287960.0 769000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D11 mock treatment 5582040.0 460674.28571429 0.509372324114113 1.051 0.9822 6314120.0 494000.0 0.54 6286120.0 767000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D12 mock treatment 5407800.0 286434.28571429 0.316713353327349 0.9054 0.9606 6345640.0 526000.0 0.58 6192360.0 673000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D13 compound treatment 5882880.0 761514.28571429 0.842014224776936 1.279 0.934 3188010 PK04_108075 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 6751880.0 932000.0 1.02 5870480.0 351000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D14 compound treatment 6059520.0 938154.28571429 1.03732690039547 1.1293 0.8102 3071531 PK04_108076 CCOC(=O)[C@@H]1[C@@H]2CN(CCC2=C[C@@H]3[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]4CCCN4C(=O)[C@@H]13)S(=O)(=O)c5ccc(C)cc5 5808680.0 -11100.0 -0.01 6446720.0 927000.0 0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D15 mock treatment 5524080.0 402714.28571429 0.44528535242678 0.8781 0.9891 6379560.0 560000.0 0.61 5980160.0 461000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D16 mock treatment 5568160.0 446794.28571429 0.494025064503689 0.8515 0.9998 6277280.0 458000.0 0.5 5997320.0 478000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D17 compound treatment 5669920.0 548554.28571429 0.60654214937089 0.5227 0.7176 3071578 PK04_108077 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 5734400.0 -85400.0 -0.09 5910080.0 391000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D18 compound treatment 5798600.0 677234.28571429 0.748824956767819 0.8356 0.9143 3071579 PK04_108078 O=C1C=C(C(=O)C2=C1CC(=CC2)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 6025720.0 206000.0 0.23 5990560.0 471000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D19 compound treatment 5645360.0 523994.28571429 0.579385903259074 0.4382 0.6769 3071580 PK04_108079 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc6ccccc6)NC2=O)[C@@H]7O[C@]7(C)[C@H]4C 6069280.0 250000.0 0.27 5426000.0 -93200.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D20 compound treatment 5511760.0 390394.28571429 0.431663000957009 0.7815 0.9994 3188011 PK04_108080 O=C1C=C(C(=O)c2ccc(cc12)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 6248080.0 428000.0 0.47 5970520.0 451000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D21 compound treatment 5081840.0 -39525.7142857099 -0.0437039912413716 -0.9465 -0.7034 3188012 PK04_108081 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 4618560.0 -1200000.0 -1.32 5240040.0 -279000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D22 compound treatment 4866920.0 -254445.71428571 -0.281343258926699 -0.3927 -0.9753 3071581 PK04_108082 O=C1C2CC=C(CC2C(=O)c3ccccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 5599840.0 -220000.0 -0.24 5361800.0 -157000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D23 compound treatment 5268560.0 147194.28571429 0.162754244670616 -0.1222 -0.3325 3188013 PK04_108083 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 5775520.0 -44200.0 -0.05 5194360.0 -325000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 D24 compound treatment 4911600.0 -209765.71428571 -0.231940120641847 -1.065 -0.8478 3071582 PK04_108084 O=C1c2ccccc2C(=O)c3cc(ccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 5388920.0 -431000.0 -0.47 4382440.0 -1140000.0 -1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E01 mock treatment 4796200.0 -325165.71428571 -0.359539094636295 -0.937 -0.8576 4909560.0 -910000.0 -1.0 5253520.0 -266000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E02 mock treatment 4976480.0 -144885.71428571 -0.160201633356233 -0.2678 -0.4908 5374280.0 -445000.0 -0.49 5702840.0 184000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E03 compound treatment 5368880.0 247514.28571429 0.273679106638753 -0.0356 -0.0859 3188014 PK04_108085 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5536760.0 -283000.0 -0.31 5493920.0 -25300.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E04 compound treatment 5235760.0 114394.28571429 0.126486945303043 -0.2155 -0.2292 3071583 PK04_108086 C/C=C/CN([C@H](CO)c1ccccc1)C(=O)C#Cc2ccccc2 5034880.0 -785000.0 -0.86 5877680.0 358000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E05 compound treatment 5206960.0 85594.2857142901 0.0946424873217596 0.1249 0.5652 3188015 PK04_108087 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5758960.0 -60800.0 -0.07 5706920.0 188000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E06 compound treatment 5702400.0 581034.28571429 0.64245562142756 0.4507 0.6525 3071584 PK04_108088 OCC(NCC#C)/C=C/c1ccccc1 5731680.0 -88100.0 -0.1 5753120.0 234000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E07 compound treatment 5667480.0 546114.28571429 0.603844216125254 0.7905 0.92 3188129 PK04_108089 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 5985600.0 166000.0 0.18 6100960.0 582000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E08 compound treatment 5878440.0 757074.28571429 0.837104870838155 1.3193 0.9933 3071585 PK04_108090 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 6560160.0 740000.0 0.81 6154200.0 635000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E09 mock treatment 5683360.0 561994.28571429 0.621402896428823 0.8788 0.9854 6192680.0 373000.0 0.41 6009800.0 491000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E10 mock treatment 4363200.0 -758165.71428571 -0.838311674702118 0.1184 0.106 6301160.0 481000.0 0.53 6033560.0 514000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E11 compound treatment 5495520.0 374154.28571429 0.413706264928674 0.6607 0.8946 3071586 PK04_108091 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 6364960.0 545000.0 0.6 5652400.0 133000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E12 compound treatment 5686600.0 565234.28571429 0.624985397951717 0.7508 0.7654 3188130 PK04_108092 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 6506520.0 687000.0 0.75 5442800.0 -76400.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E13 compound treatment 6201240.0 1079874.28571429 1.19402817071171 1.3456 0.9336 3188131 PK04_108093 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 6387320.0 568000.0 0.62 6032520.0 513000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E14 compound treatment 5639160.0 517794.28571429 0.572530499110325 1.1197 0.9966 3071587 PK04_108094 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 6431840.0 612000.0 0.67 6213360.0 694000.0 0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E15 compound treatment 5933040.0 811674.28571429 0.897476655761005 1.2345 0.9663 3188132 PK04_108095 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 6232360.0 413000.0 0.45 6305280.0 786000.0 0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E16 compound treatment 5635160.0 513794.28571429 0.568107657724036 -0.055 -0.0737 3071588 PK04_108096 BrC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 5441920.0 -378000.0 -0.41 5270560.0 -249000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E17 mock treatment 5481480.0 360114.28571429 0.398182091662799 0.6385 0.9984 6145560.0 326000.0 0.36 5868960.0 350000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E18 mock treatment 5371560.0 250194.28571429 0.276642410367567 0.4528 0.9477 6149240.0 329000.0 0.36 5665520.0 146000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E19 compound treatment 5558840.0 437474.28571429 0.483719844073635 0.3596 0.6189 3188133 PK04_108097 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5685320.0 -134000.0 -0.15 5804640.0 285000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E20 compound treatment 4785200.0 -336165.71428571 -0.371701908448591 -0.6335 -0.9273 3071589 PK04_108098 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 5323400.0 -496000.0 -0.54 5337880.0 -181000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E21 compound treatment 4605160.0 -516205.71428571 -0.570773999245475 -0.5788 -0.8934 3188134 PK04_108099 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 5604960.0 -215000.0 -0.24 5323480.0 -196000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E22 compound treatment 5065200.0 -56165.7142857099 -0.0621030114083353 -0.7543 -0.6142 3071590 PK04_108100 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 4699920.0 -1120000.0 -1.23 5501320.0 -17900.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E23 compound treatment 4926640.0 -194725.71428571 -0.215310237029399 -0.7156 -0.9471 3188135 PK04_108101 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 5344120.0 -476000.0 -0.52 5017840.0 -501000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 E24 compound treatment 4528640.0 -592725.71428571 -0.65538295496519 -1.7819 -0.9686 3071591 PK04_108102 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 4707160.0 -1110000.0 -1.22 4310960.0 -1210000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F01 mock treatment 5247120.0 125754.28571429 0.139047814840105 -0.4227 -0.5504 5139720.0 -680000.0 -0.74 5393200.0 -126000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F02 mock treatment 5144600.0 23234.2857142901 0.0256903901095085 -0.387 -0.6491 5285360.0 -534000.0 -0.59 5408880.0 -110000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F03 compound treatment 5391480.0 270114.28571429 0.298668160471288 0.231 0.7008 3188136 PK04_108103 CC(C)C[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 5943200.0 123000.0 0.14 5485560.0 -33700.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F04 compound treatment 5287880.0 166514.28571429 0.184116568566393 0.5802 0.8883 3071592 PK04_108104 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 6041960.0 222000.0 0.24 6094720.0 575000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F05 compound treatment 6065000.0 943634.28571429 1.04338619309469 0.9006 0.8134 3188137 PK04_108105 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](C)NC4=O)[C@@H]6O[C@@]61C 6015400.0 196000.0 0.21 5820440.0 301000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F06 compound treatment 5441520.0 320154.28571429 0.353997906213768 0.5875 0.9983 3071592 PK04_108106 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 6103840.0 284000.0 0.31 5870400.0 351000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F07 compound treatment 5476560.0 355194.28571429 0.392741996757663 1.0605 0.9634 3071593 PK04_108107 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 6557440.0 738000.0 0.81 6153240.0 634000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F08 compound treatment 5717520.0 596154.28571429 0.659173961867734 0.2026 0.2786 3188138 PK04_108108 Cc1ccc(cc1)S(=O)(=O)N(CCC=C)CC#C[C@H]2Oc3ccccc3S(=O)(=O)N4CCC[C@@H]24 5818120.0 -1640.0 0.0 5213800.0 -305000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F09 mock treatment 5370760.0 249394.28571429 0.275757842090309 0.6115 0.9881 6184880.0 365000.0 0.4 5901480.0 382000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F10 mock treatment 6028520.0 907154.28571429 1.00304987965173 1.1201 0.9261 6334000.0 514000.0 0.56 5891840.0 373000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F11 compound treatment 5937880.0 816514.28571429 0.902828293838415 1.4983 0.9937 3188139 PK04_108109 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 6487360.0 668000.0 0.73 6477040.0 958000.0 0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F12 compound treatment 5715560.0 594194.28571429 0.657006769588452 1.2015 0.9989 3071594 PK04_108110 O=S1(=O)N2CCC[C@H]2[C@H](Oc3ccccc31)C#C 6490960.0 671000.0 0.74 6205840.0 687000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F13 compound treatment 5774200.0 652834.28571429 0.721845624311454 1.1832 0.9943 3188140 PK04_108111 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](C)NC(=O)[C@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 6501600.0 682000.0 0.75 6098040.0 579000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F14 compound treatment 5854120.0 732754.28571429 0.810213995209516 1.5895 0.9211 3414064 PK04_108112 O=S1(=O)N2CCC[C@@H]2[C@@H](Oc3ccccc31)C#C 6281440.0 462000.0 0.51 6951360.0 1430000.0 1.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F15 compound treatment 6207880.0 1086514.28571429 1.20137008741295 1.3468 0.9317 3071596 PK04_108113 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](C)NC(=O)[C@@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 6387280.0 568000.0 0.62 6027360.0 508000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F16 compound treatment 5423360.0 301994.28571429 0.333918206320014 0.506 0.8399 3188141 PK04_108114 C=CC(=C)[C@H]1Oc2ccccc2S(=O)(=O)N3CCC[C@@H]13 5858960.0 39200.0 0.04 6017000.0 498000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F17 mock treatment 5466040.0 344674.28571429 0.381109923911722 0.6916 0.9456 6345680.0 526000.0 0.58 5759200.0 240000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F18 mock treatment 5099320.0 -22045.7142857099 -0.0243761743832871 0.6219 0.7953 6281280.0 462000.0 0.51 6113280.0 594000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F19 compound treatment 5495960.0 374594.28571429 0.414192777481166 0.6258 0.9936 3188142 PK04_108115 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 6106720.0 287000.0 0.31 5873520.0 354000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F20 compound treatment 4341160.0 -780205.71428571 -0.862681530740573 -1.7114 -0.9451 3071597 PK04_108116 Cc1ccc(cc1)S(=O)(=O)NC/C=C\C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 4491240.0 -1330000.0 -1.45 4874800.0 -644000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F21 compound treatment 5037880.0 -83485.7142857099 -0.0923110180766917 0.0824 0.4169 3188143 PK04_108117 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC(=O)[C@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 5962000.0 142000.0 0.16 5598240.0 79000.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F22 compound treatment 5393840.0 272474.28571429 0.301277636889199 0.3011 0.7094 3071598 PK04_108118 Cc1ccc(cc1)S(=O)(=O)NC/C=C/C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 5755520.0 -64200.0 -0.07 5808880.0 290000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F23 compound treatment 5431240.0 309874.28571429 0.342631203851004 0.2544 0.6413 3188144 PK04_108119 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC(=O)[C@@H](C)NC4=O)[C@@H]5O[C@@]51C 5743400.0 -76400.0 -0.08 5700280.0 181000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 F24 compound treatment 4254720.0 -866645.71428571 -0.958259133098286 -2.4215 -0.9752 3188260 PK04_108120 CC(=O)O[C@@H]([C@@H]1CCCN1S(=O)(=O)c2ccccc2[N+](=O)[O-])C(=C)C3=CCN(C3)S(=O)(=O)c4ccc(C)cc4 4411800.0 -1410000.0 -1.54 3831240.0 -1690000.0 -1.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G01 compound treatment 4288160.0 -833205.71428571 -0.921284179108907 -1.3135 -0.9701 3071599 PK04_108121 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 5033000.0 -787000.0 -0.86 5028760.0 -490000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G02 compound treatment 4378840.0 -742525.71428571 -0.821018364881727 -1.3523 -0.9543 3188261 PK04_108122 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3cccc(C)c3)C(=O)[C@@]42CO4 4853800.0 -966000.0 -1.06 5057560.0 -462000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G03 mock treatment 5050640.0 -70725.7142857099 -0.0782021540544286 0.4497 0.6608 6404400.0 585000.0 0.64 5735320.0 216000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G04 mock treatment 5689640.0 568274.28571429 0.628346757405297 0.6559 0.9049 6024560.0 205000.0 0.22 5801720.0 282000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G05 compound treatment 5033760.0 -87605.7142857099 -0.0968665447045697 0.5385 0.728 3188262 PK04_108123 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 6233080.0 413000.0 0.45 6094200.0 575000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G06 compound treatment 5378680.0 257314.28571429 0.284515068035162 -0.0049 -0.0134 3071600 PK04_108124 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(OC)C(=O)[C@@]43CO4)Br 5747240.0 -72500.0 -0.08 5306440.0 -213000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G07 compound treatment 5994080.0 872714.28571429 0.96496921531578 1.2971 0.9752 3189036 PK04_108125 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 6322160.0 502000.0 0.55 6248080.0 729000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G08 compound treatment 5244320.0 122954.28571429 0.135951825869702 0.5468 0.9126 3071601 PK04_108126 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 6120680.0 301000.0 0.33 5999080.0 480000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G09 compound treatment 6148760.0 1027394.28571429 1.13600049172359 1.824 0.9934 3188263 PK04_108127 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 6624720.0 805000.0 0.88 6656840.0 1140000.0 1.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G10 compound treatment 5699240.0 577874.28571429 0.638961576732391 1.0507 0.9767 3071602 PK04_108128 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 6212000.0 392000.0 0.43 6267920.0 749000.0 0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G11 compound treatment 6227400.0 1106034.28571429 1.22295355337804 1.5272 0.9035 3188264 PK04_108129 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 6851200.0 1030000.0 1.13 5810800.0 292000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G12 compound treatment 5838560.0 717194.28571429 0.79300914221685 0.661 0.5962 3071603 PK04_108130 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 5506600.0 -313000.0 -0.34 6211560.0 692000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G13 compound treatment 5912840.0 791474.28571429 0.875141306760243 1.9547 0.9795 3188265 PK04_108131 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 7130840.0 1310000.0 1.44 6590080.0 1070000.0 1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G14 compound treatment 5342720.0 221354.28571429 0.244753723972421 0.959 0.86 3071604 PK04_108132 CCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 6192080.0 372000.0 0.41 6524240.0 1010000.0 1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G15 compound treatment 5754240.0 632874.28571429 0.69977564579387 0.8376 0.9468 3188266 PK04_108133 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 6095120.0 275000.0 0.3 5967160.0 448000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G16 compound treatment 4848960.0 -272405.71428571 -0.301201816751138 0.2952 0.4543 3071651 PK04_108134 IC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 6166040.0 346000.0 0.38 5950960.0 432000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G17 compound treatment 5328280.0 206914.28571429 0.228787266567916 0.3484 0.9681 3188267 PK04_108135 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 6044800.0 225000.0 0.25 5646960.0 128000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G18 compound treatment 5500040.0 378674.28571429 0.418704075695181 0.437 0.7512 3071652 PK04_108136 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 5764040.0 -55700.0 -0.06 5917080.0 398000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G19 mock treatment 5388400.0 267034.28571429 0.295262572603845 0.7336 0.9139 6449480.0 630000.0 0.69 5804040.0 285000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G20 mock treatment 5539520.0 418154.28571429 0.462357520177857 0.8252 0.9931 6322960.0 503000.0 0.55 5933640.0 414000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G21 compound treatment 5228440.0 107074.28571429 0.118393145566134 0.7493 0.8772 3189164 PK04_108137 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 6449600.0 630000.0 0.69 6007120.0 488000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G22 compound treatment 5009080.0 -112285.71428571 -0.124155476057975 -0.1458 -0.5744 3071653 PK04_108138 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 5891520.0 71800.0 0.08 5313040.0 -206000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G23 compound treatment 5210520.0 89154.2857142901 0.0985788161555572 0.1381 0.6357 3189167 PK04_108139 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 5776720.0 -43000.0 -0.05 5706400.0 187000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 G24 compound treatment 4736400.0 -384965.71428571 -0.425660573361321 -0.9238 -0.9745 3188268 PK04_108140 CCCCO[C@H]1C[C@H]2C(=C[C@]1(CO)C(=O)[C@@]32CO3)Br 5175680.0 -644000.0 -0.71 5051880.0 -467000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H01 compound treatment 4792560.0 -328805.71428571 -0.363563880297818 -1.1724 -0.8989 3188269 PK04_108141 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 4785280.0 -1030000.0 -1.13 4986960.0 -532000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H02 compound treatment 5231520.0 110154.28571429 0.121798733433576 -0.0441 -0.2054 3071654 PK04_108142 [O-][N+](=O)c1ccccc1S(=O)(=O)N2CCC[C@@H]2[C@H]3OCC=C3C(=C)C=C 5798960.0 -20800.0 -0.02 5344440.0 -175000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H03 mock treatment 5068160.0 -53205.7142857099 -0.0588301087824812 0.0278 0.2817 5853200.0 33400.0 0.04 5589400.0 70200.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H04 mock treatment 5580240.0 458874.28571429 0.507382045490283 0.2881 0.3991 5484360.0 -335000.0 -0.37 5876920.0 358000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H05 compound treatment 6027240.0 905874.28571429 1.00163457040812 1.0912 0.9172 3188270 PK04_108143 CC(C)C[C@@H]1NC(=O)CNC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 6139720.0 320000.0 0.35 6055360.0 536000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H06 compound treatment 5318840.0 197474.28571429 0.218349360896273 0.9531 0.909 3071655 PK04_108144 CN1C(=O)C2CC=C(CC2C1=O)C3=CCO[C@@H]3[C@H]4CCCN4S(=O)(=O)c5ccccc5[N+](=O)[O-] 6577440.0 758000.0 0.83 6119760.0 601000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H07 compound treatment 5450200.0 328834.28571429 0.363595472022016 0.8091 0.9312 3188271 PK04_108145 CC(C)C[C@H]1NC(=O)CNC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 6106120.0 286000.0 0.31 6240800.0 722000.0 0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H08 compound treatment 5781840.0 660474.28571429 0.730293251359267 0.881 0.913 3071656 PK04_108146 CN1C(=C)C2CC3C4C(C5CO[C@H]([C@H]6CCCN6S(=O)(=O)c7ccccc7[N+](=O)[O-])C5=C3CC2C1=O)C(=O)N(C)C4=O 5999000.0 179000.0 0.2 6116440.0 597000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H09 compound treatment 5633520.0 512154.28571429 0.566294292755657 0.2059 0.3041 3188272 PK04_108147 CC(C)C[C@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 5943600.0 124000.0 0.14 5175160.0 -344000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H10 compound treatment 5821600.0 700234.28571429 0.774256294738983 1.2741 0.9992 3071529 PK04_108148 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 6487360.0 668000.0 0.73 6218160.0 699000.0 0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H11 compound treatment 5539920.0 418554.28571429 0.462799804316486 0.9611 0.9853 3188273 PK04_108149 CC(C)C[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC1=O)[C@@H]6O[C@]6(C)[C@H]4C 6447920.0 628000.0 0.69 6031400.0 512000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H12 compound treatment 5826080.0 704714.28571429 0.779209877091627 1.3373 0.9946 3071527 PK04_108150 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 6431360.0 612000.0 0.67 6383440.0 864000.0 0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H13 compound treatment 5911960.0 790594.28571429 0.87416828165526 1.0922 0.8655 3071658 PK04_108151 CC(C)C[C@H]1NC(=O)[C@@H](C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 6644120.0 824000.0 0.9 5633640.0 114000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H14 compound treatment 5421400.0 300034.28571429 0.331751014040732 1.1187 0.936 3188274 PK04_108152 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 6662840.0 843000.0 0.92 6199440.0 680000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H15 compound treatment 6038960.0 917594.28571429 1.01459349566995 1.3692 0.9475 3188275 PK04_108153 CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 6679160.0 859000.0 0.94 5933520.0 414000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H16 compound treatment 5736040.0 614674.28571429 0.679651717486254 1.015 0.9835 3071661 PK04_108154 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 6407520.0 588000.0 0.64 5952480.0 433000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H17 compound treatment 5548960.0 427594.28571429 0.4727954258495 0.2933 0.5315 3188391 PK04_108155 CC(C)C[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 5652840.0 -167000.0 -0.18 5736480.0 217000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H18 compound treatment 5674000.0 552634.28571429 0.611053447584906 0.9293 0.8758 3071664 PK04_108156 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)N(Cc6ccccc6)C3=O 5950200.0 130000.0 0.14 6371960.0 853000.0 0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H19 mock treatment 5302680.0 181314.28571429 0.200481081695664 0.5394 0.9243 6268840.0 449000.0 0.49 5760440.0 241000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H20 mock treatment 5205240.0 83874.2857142901 0.0927406655256552 0.2241 0.2328 5350760.0 -469000.0 -0.51 6325440.0 806000.0 0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H21 compound treatment 5337200.0 215834.28571429 0.238650202859341 0.5243 0.9219 3188392 PK04_108157 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)CNC4=O)[C@@H]6O[C@@]61C 5992480.0 173000.0 0.19 5997760.0 479000.0 0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H22 compound treatment 4923840.0 -197525.71428571 -0.218406225999801 -0.1725 -0.7638 3071666 PK04_108158 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(Cc4ccccc4)C3=O 5777160.0 -42600.0 -0.05 5485600.0 -33600.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H23 compound treatment 5133720.0 12354.2857142901 0.0136602615388014 -0.0291 -0.0662 3188393 PK04_108159 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@@H]6CCCN6C2=O)[C@@H]7O[C@]7(C)[C@H]4C 5507920.0 -312000.0 -0.34 5795640.0 276000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 H24 compound treatment 4783640.0 -337725.71428571 -0.373426816589244 -0.9079 -0.9681 3071711 PK04_108160 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(Cc4ccccc4)C3=O 5178480.0 -641000.0 -0.7 5024120.0 -495000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I01 compound treatment 5057800.0 -63565.7142857099 -0.0702852679729707 -0.6469 -0.8155 3188394 PK04_108161 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5165880.0 -654000.0 -0.72 5186280.0 -333000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I02 compound treatment 4692560.0 -428805.71428571 -0.474134914955052 -1.8067 -0.9321 3071714 PK04_108162 OC[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 4552640.0 -1270000.0 -1.39 4256200.0 -1260000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I03 compound treatment 4775720.0 -345645.71428571 -0.382184042534096 -0.2873 -0.7335 3188395 PK04_108163 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5783560.0 -36200.0 -0.04 5443760.0 -75500.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I04 compound treatment 4525360.0 -596005.71428571 -0.659009684901948 -1.0387 -0.9054 3071715 PK04_108164 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 4988280.0 -831000.0 -0.91 5290600.0 -229000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I05 mock treatment 4979320.0 -142045.71428571 -0.157061415971968 0.032 0.1422 5955280.0 136000.0 0.15 5583160.0 63900.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I06 mock treatment 5045840.0 -75525.7142857099 -0.0835095637179759 0.3452 0.7014 6166840.0 347000.0 0.38 5819520.0 300000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I07 compound treatment 5331360.0 209994.28571429 0.232192854435359 0.0375 0.1001 3188396 PK04_108165 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 5569760.0 -250000.0 -0.27 5625400.0 106000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I08 compound treatment 4911880.0 -209485.71428571 -0.231630521744807 -0.1976 -0.5508 3071717 PK04_108166 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 5599800.0 -220000.0 -0.24 5649080.0 130000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I09 compound treatment 5427080.0 305714.28571429 0.338031448809263 0.422 0.8494 3188397 PK04_108167 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 6151160.0 331000.0 0.36 5549160.0 29900.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I10 compound treatment 5447760.0 326394.28571429 0.360897538776379 0.6064 0.7544 3071720 PK04_108168 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 6475040.0 655000.0 0.72 5491120.0 -28100.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I11 compound treatment 5755960.0 634594.28571429 0.701677467589975 1.1135 0.9974 3188398 PK04_108169 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 6403000.0 583000.0 0.64 6105320.0 586000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I12 compound treatment 5398160.0 276794.28571429 0.306054305586391 0.8288 0.9307 3071724 PK04_108170 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@]4(CO4)C2=O 6495600.0 676000.0 0.74 5907120.0 388000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I13 compound treatment 6018360.0 896994.28571429 0.991815862530557 1.1275 0.9342 3071725 PK04_108171 COC(=O)[C@H](Cc1ccc(O)cc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 6190880.0 371000.0 0.41 6071920.0 553000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I14 compound treatment 5452120.0 330754.28571429 0.365718435887435 0.3381 0.7673 3071727 PK04_108172 C[C@]12COC[C@@]2(C=C(Br)[C@@H]3C1)C(=O)[C@@]43CO4 5797240.0 -22500.0 -0.02 5763000.0 244000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I15 compound treatment 5101280.0 -20085.7142857099 -0.0222089821040053 -0.6767 -0.7027 3188399 PK04_108173 COC(=O)[C@H](Cc1ccc(O)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 4961880.0 -858000.0 -0.94 5309600.0 -210000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I16 compound treatment 5274640.0 153274.28571429 0.169476963577776 -0.0179 -0.0348 3071766 PK04_108174 CCCCC[C@H]1OC[C@@]2(C=C(Br)[C@@H]3CC12)C(=O)[C@@]43CO4 5428200.0 -392000.0 -0.43 5746720.0 227000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I17 compound treatment 5093720.0 -27645.7142857099 -0.0305681523240922 -0.9205 -0.8214 3188400 PK04_108175 COC(=O)[C@H](Cc1ccc(OCC#C)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 4990000.0 -830000.0 -0.91 4866440.0 -653000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I18 compound treatment 5623200.0 501834.28571429 0.554883361979031 0.8167 0.9774 3071767 PK04_108176 CC1(C)OC[C@@]2(C=C(Br)[C@@H]3C[C@H]12)C(=O)[C@@]43CO4 6305360.0 486000.0 0.53 5845920.0 327000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I19 compound treatment 5840800.0 719434.28571429 0.795485933393172 0.0301 0.0311 3188401 PK04_108177 Oc1ccc(C[C@@H]2N(CC#C)[C@@H](/C=C/C3CC3)[C@@H](Cc4ccccc4)OC2=O)cc1 5364680.0 -455000.0 -0.5 5275200.0 -244000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I20 compound treatment 5265160.0 143794.28571429 0.15899482949227 0.1837 0.2526 3071770 PK04_108178 BrC1=C[C@]23COCC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 5440040.0 -380000.0 -0.42 6092240.0 573000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I21 mock treatment 4832320.0 -289045.71428571 -0.319600836918102 -0.212 -0.6054 5887840.0 68100.0 0.07 5397520.0 -122000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I22 mock treatment 4871320.0 -250045.71428571 -0.276478133401781 -0.4064 -0.9918 5617600.0 -202000.0 -0.22 5313920.0 -205000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I23 compound treatment 4577840.0 -543525.71428571 -0.600982005913831 -0.4597 -0.7069 3188402 PK04_108179 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccc(OCC#C)cc4 5597240.0 -223000.0 -0.24 5567480.0 48200.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 I24 compound treatment 4469440.0 -651925.71428571 -0.720841007482273 -1.3064 -0.993 3071774 PK04_108180 C=CCC1=C[C@H]2[C@H]([C@H]3C=C[C@]2(CC=C)C(=O)[C@@]43CO4)[C@@]5(CO5)C1=O 5019360.0 -800000.0 -0.88 4856280.0 -663000.0 -0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J01 compound treatment 4746800.0 -374565.71428571 -0.414161185756969 -0.7086 -0.9567 3188403 PK04_108181 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 5309360.0 -510000.0 -0.56 5265880.0 -253000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J02 compound treatment 4745120.0 -376245.71428571 -0.41601877913921 -0.8447 -0.9685 3071776 PK04_108182 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(Cc5ccccc5)C3=O 5213520.0 -606000.0 -0.66 5137440.0 -382000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J03 compound treatment 4746480.0 -374885.71428571 -0.414515013067872 -0.3937 -0.8398 3188404 PK04_108183 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@@H](C)NC4=O)[C@@H]6O[C@@]61C 5768960.0 -50800.0 -0.06 5308240.0 -211000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J04 compound treatment 5232160.0 110794.28571429 0.122506388055383 0.1702 0.2497 3188405 PK04_108184 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)C 5472760.0 -347000.0 -0.38 6069480.0 550000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J05 mock treatment 5172760.0 51394.2857142901 0.0568271934689856 0.1914 0.2673 5501680.0 -318000.0 -0.35 6140040.0 621000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J06 mock treatment 5276280.0 154914.28571429 0.171290328546154 0.6114 0.7995 6484520.0 665000.0 0.73 5678280.0 159000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J07 compound treatment 5066720.0 -54645.7142857099 -0.0604223316815454 -0.0593 -0.222 3070928 PK04_108185 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@H](C)NC4=O)[C@@H]6O[C@@]61C 5633480.0 -186000.0 -0.2 5680320.0 161000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J08 compound treatment 5186520.0 65154.2857142901 0.072041767837821 0.224 0.6285 3070929 PK04_108186 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(C)C4=O 6137200.0 317000.0 0.35 5487680.0 -31600.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J09 compound treatment 5081720.0 -39645.7142857099 -0.0438366764829603 0.4567 0.7461 3070930 PK04_108187 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C1=O)[C@@H]6O[C@]6(C)[C@H]3C 6100280.0 281000.0 0.31 6045040.0 526000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J10 compound treatment 5006520.0 -114845.71428571 -0.1269860945452 0.2543 0.3144 3188406 PK04_108188 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)COc5ccccc5 6524680.0 705000.0 0.77 5315400.0 -204000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J11 compound treatment 5109560.0 -11805.7142857099 -0.0130537004343863 0.6969 0.7612 3188407 PK04_108189 CC(C)C[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C1=O)[C@@H]6O[C@]6(C)[C@H]3C 6179240.0 359000.0 0.39 6342720.0 823000.0 0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J12 compound treatment 5740640.0 619274.28571429 0.684737985080486 1.032 0.7951 3070931 PK04_108190 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(C)C3=O 5819880.0 121.0 0.0 6617840.0 1100000.0 1.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J13 compound treatment 5594160.0 472794.28571429 0.52277353351457 0.6237 0.9013 3070932 PK04_108191 OCC(NC(=O)OCC1c2ccccc2-c3ccccc13)C=C 5929680.0 110000.0 0.12 5954840.0 436000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J14 compound treatment 5443520.0 322154.28571429 0.356209326906912 0.6252 0.9867 3070933 PK04_108192 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(C)C3=O 6217880.0 398000.0 0.44 5808920.0 290000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J15 compound treatment 5161360.0 39994.2857142901 0.0442220955180609 0.2153 0.5531 3188522 PK04_108193 COc1ccc(CN([C@H](COC(=O)OC(C)(C)C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 6169440.0 350000.0 0.38 5465200.0 -54000.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J16 compound treatment 5261680.0 140314.28571429 0.155146957486198 0.3837 0.6863 3188523 PK04_108194 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(C)C3=O 6309640.0 490000.0 0.54 5492320.0 -26900.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J17 compound treatment 5111640.0 -9725.7142857099 -0.0107538229135159 0.1891 0.5166 3070934 PK04_108195 CC(=O)OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 5795440.0 -24300.0 -0.03 5882920.0 364000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J18 compound treatment 4962440.0 -158925.71428571 -0.175725806622109 0.064 0.0806 3188524 PK04_108196 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 5468080.0 -352000.0 -0.39 6188520.0 669000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J19 compound treatment 4988120.0 -133245.71428571 -0.147331164922131 0.0959 0.175 3070935 PK04_108197 O=C(CCCCCCC(=O)Nc1ccccc1)N/N=C/c2ccccc2 5653600.0 -166000.0 -0.18 6012880.0 494000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J20 compound treatment 4698720.0 -422645.71428571 -0.467323739220167 -0.274 -0.5842 3188525 PK04_108198 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 5790800.0 -29000.0 -0.03 5543560.0 24300.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J21 mock treatment 4939640.0 -181725.71428571 -0.200936002523958 -0.2385 -0.6311 5540320.0 -279000.0 -0.31 5612760.0 93500.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J22 mock treatment 4748400.0 -372965.71428571 -0.412392049202453 -0.5684 -0.972 5617080.0 -203000.0 -0.22 5170320.0 -349000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J23 compound treatment 4432520.0 -688845.71428571 -0.761663833477724 -1.1887 -0.9948 3070936 PK04_108199 C/C(=N\O)/C(=O)NCCCCCNC(=O)OCc1ccccc1 5278760.0 -541000.0 -0.59 4817000.0 -702000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 J24 compound treatment 3795920.0 -1325445.71428571 -1.46555904010568 -1.8981 -0.9719 3188526 PK04_108200 OB1C[C@H]2C(=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O)[C@@H](CCc6ccccc6)O1 4937680.0 -882000.0 -0.97 4666200.0 -853000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K01 compound treatment 4775840.0 -345525.71428571 -0.382051357292508 -1.1471 -0.9572 3070937 PK04_108201 COC(=O)[C@H](Cc1ccc(O)cc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 5054920.0 -765000.0 -0.84 4754800.0 -764000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K02 compound treatment 4450920.0 -670445.71428571 -0.741318763100793 -1.4753 -0.9955 3188527 PK04_108202 CC1=C[C@]2(CO)C(=O)[C@]3(CO3)[C@H]1[C@@H]4[C@@]5(CO5)C(=O)C(=C[C@@]42C)CO 4967440.0 -852000.0 -0.93 4641880.0 -877000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K03 compound treatment 4392520.0 -728845.71428571 -0.805892247340617 -1.0919 -0.9531 3188528 PK04_108203 Oc1ccc(C[C@@H]2N3CC4=CCCC=C[C@@H]4[C@H]3[C@@H](Cc5ccccc5)OC2=O)cc1 5499760.0 -320000.0 -0.35 4786880.0 -732000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K04 compound treatment 4870720.0 -250645.71428571 -0.277141559609724 -2.3048 -0.8679 3070938 PK04_108204 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 3947400.0 -1870000.0 -2.05 3860680.0 -1660000.0 -1.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K05 compound treatment 5260280.0 138914.28571429 0.153598963000997 -0.1197 -0.3959 3188529 PK04_108205 COC(=O)[C@H](Cc1ccccc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 5621600.0 -198000.0 -0.22 5375840.0 -143000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K06 compound treatment 4738520.0 -382845.71428571 -0.423316467426588 -1.3665 -0.7864 3070939 PK04_108206 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)c4ccccc4)C2 4302480.0 -1520000.0 -1.66 5238320.0 -281000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K07 mock treatment 5254280.0 132914.28571429 0.146964700921563 0.2504 0.984 5921480.0 102000.0 0.11 5694040.0 175000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K08 mock treatment 5501560.0 380194.28571429 0.420384755421971 0.183 0.4247 5811200.0 -8560.0 -0.01 5425520.0 -93700.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K09 compound treatment 4204640.0 -916725.71428571 -1.01363310725463 -2.0398 -0.9929 3188530 PK04_108207 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 4579680.0 -1240000.0 -1.36 4362000.0 -1160000.0 -1.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K10 compound treatment 5076120.0 -45245.7142857099 -0.0500286544237654 -0.5133 -0.8547 3188531 PK04_108208 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Oc4ccccc4)cc3)C2 5487360.0 -332000.0 -0.36 5045920.0 -473000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K11 compound treatment 4705360.0 -416005.71428571 -0.459981822518926 -1.1979 -0.9507 3070940 PK04_108209 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 4909040.0 -911000.0 -1.0 4903960.0 -615000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K12 compound treatment 5180080.0 58714.2857142901 0.0649209932058951 -0.4833 -0.7473 3188532 PK04_108210 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)C(F)(F)F)C2 5353000.0 -467000.0 -0.51 5129720.0 -390000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K13 compound treatment 4999320.0 -122045.71428571 -0.134947209040521 -0.8041 -0.8736 3188533 PK04_108211 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 5371480.0 -448000.0 -0.49 4755160.0 -764000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K14 compound treatment 5529360.0 407994.28571429 0.451123503056682 0.5126 0.9176 3070941 PK04_108212 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4[nH]ccc4c3)C2 5945040.0 125000.0 0.14 5817760.0 299000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K15 mock treatment 4983640.0 -137725.71428571 -0.152284747274775 0.1345 0.1706 6463080.0 643000.0 0.7 5201080.0 -318000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K16 mock treatment 5378640.0 257274.28571429 0.284470839621299 -0.0201 -0.0515 5583040.0 -237000.0 -0.26 5459440.0 -59800.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K17 compound treatment 4817840.0 -303525.71428571 -0.335611522736469 0.0357 0.0609 3188534 PK04_108213 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 6253040.0 433000.0 0.47 5442480.0 -76800.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K18 compound treatment 4793680.0 -327685.71428571 -0.362325484709657 -0.3822 -0.8492 3070942 PK04_108214 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3cccc4[nH]ccc34)C2 5787840.0 -31900.0 -0.03 5255520.0 -264000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K19 compound treatment 5149160.0 27794.2857142901 0.0307324292898784 0.0673 0.9892 3188535 PK04_108215 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 5859320.0 39600.0 0.04 5561560.0 42300.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K20 compound treatment 4860080.0 -261285.71428571 -0.288906317697254 -0.4088 -0.8232 3070943 PK04_108216 CC(C)Oc1ccc(cc1)C(=O)N2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C 5451240.0 -369000.0 -0.4 5503760.0 -15500.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K21 compound treatment 4412840.0 -708525.71428571 -0.783424213098267 -1.3546 -1.0 3188536 PK04_108217 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 5112080.0 -708000.0 -0.77 4734200.0 -785000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K22 compound treatment 4613800.0 -507565.71428571 -0.56122066185109 -1.2007 -0.9874 3188537 PK04_108218 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Br)cc3)C2 5058800.0 -761000.0 -0.83 4836520.0 -683000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K23 mock treatment 4524040.0 -597325.71428571 -0.660469222559423 -0.833 -0.9612 5402040.0 -418000.0 -0.46 5195480.0 -324000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 K24 mock treatment 4262960.0 -858405.71428571 -0.94914807984253 -1.5593 -0.9778 4807920.0 -1010000.0 -1.11 4877960.0 -641000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L01 compound treatment 4564440.0 -556925.71428571 -0.615798524557901 -1.7214 -0.9647 3070944 PK04_108219 O/N=C(\Cc1ccccc1)/C(=O)NCCCCCNC(=O)OCc2ccccc2 4790600.0 -1030000.0 -1.13 4285040.0 -1230000.0 -1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L02 compound treatment 4904960.0 -216405.71428571 -0.239282037343087 -0.4447 -0.9297 3188538 PK04_108220 CCCC[C@H]1OB(O)C[C@H]2C1=C(C)Cn3n2c(=O)n(c4ccccc4)c3=O 5690240.0 -130000.0 -0.14 5131480.0 -388000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L03 compound treatment 4801280.0 -320085.71428571 -0.353922086075707 -0.5683 -0.7612 3188539 PK04_108221 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccccc4)c5ccccc5 5843880.0 24100.0 0.03 4864680.0 -655000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L04 compound treatment 5657720.0 536354.28571429 0.593052483142708 0.4002 0.6058 3215882 PK04_108222 CCCC[C@H]1OB(O)C[C@H]2C1=C(COC)Cn3n2c(=O)n(c4ccccc4)c3=O 6047920.0 228000.0 0.25 5370080.0 -149000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L05 compound treatment 4865800.0 -255565.71428571 -0.28258165451486 -0.1806 -0.5307 3188540 PK04_108223 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccccc4)c5ccccc5 5684240.0 -136000.0 -0.15 5636960.0 118000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L06 compound treatment 5227040.0 105674.28571429 0.116845151080932 -0.2236 -0.4821 3215880 PK04_108224 CCCC[C@H]1OB(O)C[C@H]2C1=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O 5765720.0 -54000.0 -0.06 5075880.0 -443000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L07 mock treatment 5057680.0 -63685.7142857099 -0.0704179532145593 -0.3235 -0.6901 5794880.0 -24900.0 -0.03 5058280.0 -461000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L08 mock treatment 5337280.0 215914.28571429 0.238738659687067 0.0064 0.0164 5883280.0 63500.0 0.07 5223000.0 -296000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L09 compound treatment 5139040.0 17674.2857142901 0.0195426405825663 -0.0705 -0.4834 3188541 PK04_108225 C[C@@H]1ON([C@@H]([C@H]1C(=O)O)c2ccccc2)c3ccccc3 5822360.0 2600.0 0.0 5375240.0 -144000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L10 compound treatment 5120120.0 -1245.7142857099 -0.0013773991745824 -0.0944 -0.7556 3188542 PK04_108226 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 5713720.0 -106000.0 -0.12 5473440.0 -45800.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L11 compound treatment 5121760.0 394.285714290105 4.35965793796235E-4 -0.3579 -0.3114 3070947 PK04_108227 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 4850480.0 -969000.0 -1.06 5958760.0 440000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L12 compound treatment 5089640.0 -31725.7142857099 -0.0350794505381073 0.0661 0.2912 3188543 PK04_108228 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 5760320.0 -59400.0 -0.07 5733160.0 214000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L13 compound treatment 5865800.0 744434.28571429 0.82312869205748 0.8201 0.886 3188544 PK04_108229 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 6110800.0 291000.0 0.32 5796840.0 278000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L14 compound treatment 5375240.0 253874.28571429 0.280711424442953 -0.1222 -0.2705 3070948 PK04_108230 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)C=CC3=O 5553400.0 -266000.0 -0.29 5319280.0 -200000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L15 mock treatment 4965200.0 -156165.71428571 -0.172674046065569 -0.7447 -0.6838 5780680.0 -39100.0 -0.04 4448600.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L16 mock treatment 4702120.0 -419245.71428571 -0.463564324041821 -0.4372 -0.5789 5324720.0 -495000.0 -0.54 5766720.0 247000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L17 compound treatment 5038800.0 -82565.7142857099 -0.0912937645578451 -0.6622 -0.7901 3188657 PK04_108231 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5cccc(c5)C(=O)OC(C)(C)C 5576640.0 -243000.0 -0.27 4732560.0 -787000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L18 compound treatment 4780840.0 -340525.71428571 -0.376522805559646 -0.492 -0.9608 3070949 PK04_108232 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)C=CC3=O 5657800.0 -162000.0 -0.18 5222000.0 -297000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L19 compound treatment 4911160.0 -210205.71428571 -0.232426633194339 -0.8307 -0.8888 3188658 PK04_108233 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 5464680.0 -355000.0 -0.39 4704560.0 -815000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L20 compound treatment 5062680.0 -58685.7142857099 -0.0648894014816976 -0.4597 -0.5811 3070950 PK04_108234 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)C=CC3=O 5870120.0 50400.0 0.06 4735480.0 -784000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L21 compound treatment 5021440.0 -99925.7142857099 -0.110488896174341 -0.7474 -0.6842 3188659 PK04_108235 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4cccc(NC(=O)OCC5c6ccccc6-c7ccccc57)c4)c8ccc(I)cc8 4831880.0 -988000.0 -1.08 5417480.0 -102000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L22 compound treatment 5330440.0 209074.28571429 0.231175600916512 -0.3749 -0.5598 3070951 PK04_108236 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)C=CC3=O 5473400.0 -346000.0 -0.38 5019760.0 -499000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L23 mock treatment 4316080.0 -805285.71428571 -0.890412746232607 -1.1544 -0.9703 5369800.0 -450000.0 -0.49 4905200.0 -614000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 L24 mock treatment 4589160.0 -532205.71428571 -0.588465364790632 -1.6655 -0.9594 4885040.0 -935000.0 -1.02 4251120.0 -1270000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M01 compound treatment 4092920.0 -1028445.71428571 -1.13716306717369 -1.8742 -0.9799 3188660 PK04_108237 COC(=O)[C@H](Cc1ccccc1)N[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 4614200.0 -1210000.0 -1.32 4733160.0 -786000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M02 compound treatment 4809760.0 -311605.71428571 -0.344545662336774 -1.2897 -0.9234 3070952 PK04_108238 CC(C)Cc1ccc(CN2CC[C@@H](N)C2)cc1 4816960.0 -1000000.0 -1.1 4730880.0 -788000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M03 compound treatment 3870600.0 -1250765.71428571 -1.38298459142365 -2.2632 -0.9894 3188661 PK04_108239 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 4455640.0 -1360000.0 -1.49 4479880.0 -1040000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M04 compound treatment 4500640.0 -620725.71428571 -0.686342844669216 -2.355 -0.9342 3070953 PK04_108240 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3ccccc3)cc1 4039400.0 -1780000.0 -1.95 4081480.0 -1440000.0 -1.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M05 compound treatment 4216040.0 -905325.71428571 -1.0010280093037 -0.7808 -0.7268 3188662 PK04_108241 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@@H]2[C@@H](O)Cc3ccccc3)/C=C/C4CC4 5465200.0 -355000.0 -0.39 5556080.0 36800.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M06 compound treatment 4781520.0 -339845.71428571 -0.375770922523977 -0.8333 -0.9684 3070954 PK04_108242 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)c3ccccc3)cc1 5221600.0 -598000.0 -0.66 5108200.0 -411000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M07 compound treatment 4748360.0 -373005.71428571 -0.412436277616316 -0.2822 -0.5772 3188663 PK04_108243 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 5619080.0 -201000.0 -0.22 5662200.0 143000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M08 compound treatment 4806680.0 -314685.71428571 -0.347951250204217 -0.6977 -0.6958 3188664 PK04_108244 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)Nc3ccccc3)cc1 4963920.0 -856000.0 -0.94 5595720.0 76500.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M09 mock treatment 4751200.0 -370165.71428571 -0.40929606023205 -0.4133 -0.7761 5849520.0 29800.0 0.03 5181280.0 -338000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M10 mock treatment 4885680.0 -235685.71428571 -0.260600132825002 -0.5313 -0.9492 5626240.0 -194000.0 -0.21 5073120.0 -446000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M11 compound treatment 4656920.0 -464445.71428571 -0.513542431706891 -0.4736 -0.7596 3070955 PK04_108245 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 5860040.0 40300.0 0.04 5169600.0 -350000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M12 compound treatment 4932640.0 -188725.71428571 -0.208675974949965 -0.2648 -0.5988 3188665 PK04_108246 CC(C)Oc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 5930000.0 110000.0 0.12 5149840.0 -369000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M13 mock treatment 5139440.0 18074.2857142901 0.0199849247211952 0.3429 0.8378 6050160.0 230000.0 0.25 5839640.0 320000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M14 mock treatment 5133200.0 11834.2857142901 0.0130852921585838 -0.3326 -0.66 5733600.0 -86200.0 -0.09 5026120.0 -493000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M15 compound treatment 4541960.0 -579405.71428571 -0.640654893148847 -0.8449 -0.9649 3188666 PK04_108247 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 5357680.0 -462000.0 -0.51 5203560.0 -316000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M16 compound treatment 5011640.0 -109725.71428571 -0.12132485757075 -0.6156 -0.8618 3070994 PK04_108248 CC(C)Oc1ccc(CN2CC[C@@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 5245200.0 -575000.0 -0.63 5204640.0 -315000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M17 compound treatment 4911320.0 -210045.71428571 -0.232249719538887 -1.0998 -0.8842 3188667 PK04_108249 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4ccccc4Br 5254240.0 -566000.0 -0.62 4469640.0 -1050000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M18 compound treatment 4784320.0 -337045.71428571 -0.372674933553574 -0.6733 -0.9949 3070995 PK04_108250 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4OCOc4c3)C2 5415320.0 -404000.0 -0.44 5169800.0 -349000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M19 compound treatment 4495080.0 -626285.71428571 -0.692490594196158 -1.5332 -0.9166 3188668 PK04_108251 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/c2ccccc2)[C@@H](O)Cc3ccccc3 4519360.0 -1300000.0 -1.42 4982200.0 -537000.0 -0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M20 compound treatment 4749280.0 -372085.71428571 -0.411419024097469 -0.5781 -0.9864 2133134 PK04_108252 CCCCC(=O)N(CCN1CCOCC1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 5540360.0 -279000.0 -0.31 5236360.0 -283000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M21 compound treatment 3857640.0 -1263725.71428571 -1.39731459751523 -1.7355 -0.9632 3070996 PK04_108253 O[C@@H](Cc1ccccc1)[C@@H](/C=C/c2ccccc2)N(CC#C)Cc3ccccc3Br 5097840.0 -722000.0 -0.79 4704120.0 -815000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M22 compound treatment 4526840.0 -594525.71428571 -0.657373233589021 -1.2441 -0.9882 2133147 PK04_108254 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCCO4)C(=O)NCCO 5250760.0 -569000.0 -0.62 4647960.0 -871000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M23 compound treatment 4098840.0 -1022525.71428571 -1.13061726192198 -1.5877 -0.9768 3070997 PK04_108255 CCCC/C=C/[C@H]([C@@H](O)Cc1ccccc1)N(CC#Cc2ccccc2)Cc3ccccc3Br 4932240.0 -888000.0 -0.97 4874120.0 -645000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 M24 compound treatment 3809480.0 -1311885.71428571 -1.45056560780615 -2.3688 -0.9966 3188671 PK04_108256 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCCc3c[nH]c4ccccc34)[C@@H]2O)C(=O)NCCO 4499680.0 -1320000.0 -1.45 4316880.0 -1200000.0 -1.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N01 compound treatment 4252280.0 -869085.71428571 -0.960957066343922 -1.3817 -0.9068 3188672 PK04_108257 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(OC(=O)OC(C)(C)C)cc4)c5ccc(I)cc5 5560080.0 -260000.0 -0.28 4375560.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N02 compound treatment 4465600.0 -655765.71428571 -0.725086935213111 -0.8707 -0.7275 3070998 PK04_108258 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 5962520.0 143000.0 0.16 4583200.0 -936000.0 -0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N03 compound treatment 4611760.0 -509605.71428571 -0.563476310958097 -0.985 -0.9818 3188673 PK04_108259 COC(=O)CCCCCCC(=O)Nc1ccc(NC(=O)CCCC[P+](c2ccccc2)(c3ccccc3)c4ccccc4)cc1 5175040.0 -645000.0 -0.71 5084200.0 -435000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N04 compound treatment 4951160.0 -170205.71428571 -0.188198219331445 -0.4669 -0.7081 3070999 PK04_108260 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 5242800.0 -577000.0 -0.63 5530560.0 11300.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N05 compound treatment 5592320.0 470954.28571429 0.520739026476877 -0.9108 -0.5748 3188674 PK04_108261 CC(C)[C@H]1COC(=O)N1C(=O)[C@@H]2[C@@H](C)ON([C@@H]2c3ccccc3)c4ccccc4 4735080.0 -1080000.0 -1.19 4612120.0 -907000.0 -0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N06 compound treatment 4001720.0 -1119645.71428571 -1.23800385078109 -2.8499 -0.9818 3071000 PK04_108262 OC[C@@H]1[C@H]2[C@@H](CC(=C1[C@H](O)CCc3ccccc3)COc4ccccc4)C(=O)N(Cc5ccccc5)C2=O 3979640.0 -1840000.0 -2.02 3842240.0 -1680000.0 -1.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N07 compound treatment 5042560.0 -78805.7142857099 -0.0871362936547331 -0.9441 -0.8304 3188675 PK04_108263 CC(C)[C@@H](CO)NC(=O)[C@@H]1[C@@H](C)ON([C@@H]1c2ccccc2)c3ccccc3 4922680.0 -897000.0 -0.98 4955560.0 -564000.0 -0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N08 compound treatment 4730400.0 -390965.71428571 -0.432294835440755 -0.6313 -0.9536 3188676 PK04_108264 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 5634960.0 -185000.0 -0.2 5062080.0 -457000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N09 mock treatment 4859880.0 -261485.71428571 -0.289127459766568 0.1815 0.1833 6641320.0 822000.0 0.9 5224080.0 -295000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N10 mock treatment 4719240.0 -402125.71428571 -0.444634562908502 -0.256 -0.4007 6116440.0 297000.0 0.32 5196760.0 -322000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N11 compound treatment 4737440.0 -383925.71428571 -0.424510634600886 -0.6208 -0.6997 3071001 PK04_108265 COC(=O)[C@@H]1N[C@H]2[C@@H](COc3ccccc23)[C@@H]1C(=O)OC 5928600.0 109000.0 0.12 4752080.0 -767000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N12 compound treatment 5830720.0 709354.28571429 0.784340373099723 1.7775 0.9837 3188677 PK04_108266 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 6780520.0 961000.0 1.05 6757040.0 1240000.0 1.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N13 mock treatment 5261000.0 139634.28571429 0.154395074450529 -0.1858 -0.469 5693080.0 -127000.0 -0.14 5182960.0 -336000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N14 mock treatment 4766920.0 -354445.71428571 -0.391914293583933 -0.7547 -0.9966 5422440.0 -397000.0 -0.44 5040880.0 -478000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N15 compound treatment 4339360.0 -782005.71428571 -0.864671809364403 -0.8735 -0.8634 3071002 PK04_108267 OCC1CC(=NO1)c2ccccc2 5358200.0 -462000.0 -0.51 5376920.0 -142000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N16 compound treatment 4815560.0 -305805.71428571 -0.338132542326654 -0.6751 -0.9743 3188788 PK04_108268 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(Cc4ccccc4)C3=O 5348240.0 -472000.0 -0.52 5205560.0 -314000.0 -0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N17 compound treatment 4861600.0 -259765.71428571 -0.287225637970464 -0.7991 -0.8818 3071004 PK04_108269 O[C@H](C=C)[C@H]1CC(=NO1)c2ccccc2 5558120.0 -262000.0 -0.29 4711840.0 -807000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N18 compound treatment 4930000.0 -191365.71428571 -0.211595050264916 -0.7798 -0.902 3071005 PK04_108270 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)C 5449600.0 -370000.0 -0.41 4788120.0 -731000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N19 compound treatment 4709360.0 -412005.71428571 -0.455558981132637 -0.7336 -0.9593 3414065 PK04_108271 O[C@@H]([C@H]1CC(=NO1)c2ccccc2)[C@@H]3CC(=NO3)c4ccccc4 5310520.0 -509000.0 -0.56 5262800.0 -256000.0 -0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N20 compound treatment 4867720.0 -253645.71428571 -0.280458690649441 -0.787 -0.811 3188790 PK04_108272 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(C)C3=O 4985680.0 -834000.0 -0.91 5350640.0 -169000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N21 compound treatment 4385960.0 -735405.71428571 -0.813145707214132 -0.6175 -0.5281 3071008 PK04_108273 CC[C@H](C)C(=O)O[C@H]1CC[C@@]2(C)C(CCC3=C2CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CCCC(C)C)C1(C)C 6232520.0 413000.0 0.45 4813320.0 -706000.0 -0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N22 compound treatment 4650800.0 -470565.71428571 -0.520309379027913 -0.3128 -0.2722 3188791 PK04_108274 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)COc4ccccc4 6471400.0 652000.0 0.71 4786680.0 -733000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N23 compound treatment 4333200.0 -788165.71428571 -0.871482985099289 -1.7966 -0.9829 3188792 PK04_108275 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)CCl)C(C)(C)C4CC3 4623520.0 -1200000.0 -1.31 4592240.0 -927000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 N24 compound treatment 3888560.0 -1232805.71428571 -1.36312603359921 -2.3946 -0.9842 3188793 PK04_108276 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 4270720.0 -1550000.0 -1.7 4435080.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O01 compound treatment 3737800.0 -1383565.71428571 -1.52982292544846 -2.6698 -0.9985 3071055 PK04_108277 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 4501320.0 -1320000.0 -1.44 3874600.0 -1640000.0 -1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O02 compound treatment 4066280.0 -1055085.71428571 -1.16661919080638 -1.9548 -0.9995 2129060 PK04_108278 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCC3CCCCC3)[C@@H]2O)C(=O)NCCO 4782000.0 -1040000.0 -1.14 4440320.0 -1080000.0 -1.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O03 compound treatment 4269080.0 -852285.71428571 -0.942381132521507 -2.9447 -0.9537 3188794 PK04_108279 O[C@@H](Cc1ccccc1)[C@H](NCc2cccc(Cl)c2)/C=C/C3CC3 3908440.0 -1910000.0 -2.09 3461800.0 -2060000.0 -2.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O04 compound treatment 4424960.0 -696405.71428571 -0.770023003697811 -1.2702 -0.7314 2129057 PK04_108280 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC[C@@H]3CCCO3)[C@@H]2O)C(=O)NCCO 4402760.0 -1420000.0 -1.55 5640560.0 121000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O05 compound treatment 3414320.0 -1707045.71428571 -1.88749810835768 -2.3778 -0.9665 3188796 PK04_108281 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4cccc(Cl)c4 4780120.0 -1040000.0 -1.14 4430760.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O06 compound treatment 4484800.0 -636565.71428571 -0.703857296558922 -1.1223 -0.9667 2129061 PK04_108282 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC3CCCCCC3)[C@@H]2O)C(=O)NCCO 5440320.0 -379000.0 -0.42 4697760.0 -821000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O07 compound treatment 4626480.0 -494885.71428571 -0.547200254656553 -1.1914 -0.9781 3071060 PK04_108283 O[C@@H](Cc1ccccc1)[C@H](NCc2ccccc2Br)/C=C/c3ccccc3 5247720.0 -572000.0 -0.63 4632560.0 -887000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O08 compound treatment 4175520.0 -945845.71428571 -1.04583139254682 -1.4875 -0.9862 2129067 PK04_108284 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccccc3F)[C@@H]2O)C(=O)NCCO 5057240.0 -763000.0 -0.84 4826240.0 -693000.0 -0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O09 compound treatment 4505720.0 -615645.71428571 -0.680725836108628 -0.8982 -0.9741 3188797 PK04_108285 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC=C3CN2Cc4cccc(Cl)c4 5379720.0 -440000.0 -0.48 5127600.0 -392000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O10 compound treatment 4757640.0 -363725.71428571 -0.402175285600124 -0.3625 -0.8192 2129068 PK04_108286 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccc(F)cc3)[C@@H]2O)C(=O)NCCO 5656840.0 -163000.0 -0.18 5472120.0 -47100.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O11 mock treatment 5104840.0 -16525.7142857099 -0.0182726532702078 -0.8956 -0.8125 4990960.0 -829000.0 -0.91 4896120.0 -623000.0 -0.63 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O12 mock treatment 4957440.0 -163925.71428571 -0.181254358354971 -0.824 -0.884 5408760.0 -411000.0 -0.45 4726160.0 -793000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O13 compound treatment 4187560.0 -933805.71428571 -1.03251863997408 -1.0332 -0.8325 3188798 PK04_108287 COC1(C)CN(Cc2ccccc2Br)[C@H](/C=C/c3ccccc3)[C@H](Cc4ccccc4)O1 5194480.0 -625000.0 -0.68 5447160.0 -72100.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O14 compound treatment 4697520.0 -423845.71428571 -0.468650591636053 -0.7215 -0.8493 3071064 PK04_108288 CCCC(=O)N(CCc1c[nH]c2ccccc12)[C@@H]3CC(=C[C@H](Oc4c(I)cc(CO)cc4OC)[C@H]3O)C(=O)NCCO 5176560.0 -643000.0 -0.7 5442920.0 -76300.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O15 compound treatment 4450520.0 -670845.71428571 -0.741761047239422 -1.0598 -0.9827 3188799 PK04_108289 CN1C(=O)C2C3[C@H]([C@@H](O)Cc4ccccc4)N(Cc5cccc(Cl)c5)CC3=CC(C6CC6)C2C1=O 5242520.0 -577000.0 -0.63 5059160.0 -460000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O16 compound treatment 4832120.0 -289245.71428571 -0.319821978987416 -0.3609 -0.8234 2133032 PK04_108290 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4ccc(cc4)C(F)(F)F)C(=O)NCCO 5814600.0 -5160.0 -0.01 5220680.0 -299000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O17 compound treatment 4131840.0 -989525.71428571 -1.0941288204851 -1.4569 -0.977 3071066 PK04_108291 O[C@@H](Cc1ccccc1)[C@H](N(CC#C)CC2=CCCCC2)c3ccccc3Br 5213840.0 -606000.0 -0.66 4756280.0 -763000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O18 compound treatment 4314600.0 -806765.71428571 -0.892049197545534 -1.3633 -0.9666 2133035 PK04_108292 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 4930800.0 -889000.0 -0.97 5025240.0 -494000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O19 compound treatment 4218840.0 -902525.71428571 -0.997932020333301 -1.2965 -0.9651 3071068 PK04_108293 O=C(Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4ccccc4)c5ccccc5 5137200.0 -683000.0 -0.75 5020880.0 -498000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O20 compound treatment 3863960.0 -1257405.71428571 -1.39032650812489 -1.5988 -0.9402 2133267 PK04_108294 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(Cc3ccc(F)cc3)C(=O)C4CCCO4)C(=O)NCCO 5247720.0 -572000.0 -0.63 4769440.0 -750000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O21 compound treatment 4392680.0 -728685.71428571 -0.805715333685166 -1.6457 -0.9942 3071112 PK04_108295 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4cccc(Cl)c4)c5ccccc5 4877000.0 -943000.0 -1.03 4510520.0 -1010000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O22 compound treatment 4257320.0 -864045.71428571 -0.955384286197198 -1.5304 -0.9983 2133153 PK04_108296 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCOC4)C(=O)NCCO 5058240.0 -762000.0 -0.83 4660920.0 -858000.0 -0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O23 compound treatment 4011360.0 -1110005.71428571 -1.22734480304013 -1.9458 -0.9963 3188804 PK04_108297 Clc1cccc(CN2CC3=CCCC=CC3[C@@H]2[C@H](Cc4ccccc4)OC(=O)C=C)c1 4769600.0 -1050000.0 -1.15 4529920.0 -989000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 O24 compound treatment 3821720.0 -1299645.71428571 -1.43703171316411 -2.9089 -0.9846 2132929 PK04_108298 CC/C=C/C(=O)N(C[C@@H]1CCCO1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 3902360.0 -1920000.0 -2.1 4023040.0 -1500000.0 -1.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P01 compound treatment 3368160.0 -1753205.71428571 -1.93853769795546 -3.3886 -0.9968 3188805 PK04_108299 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)C(C)(C)C)C(C)(C)C4CC3 3850400.0 -1970000.0 -2.16 3751560.0 -1770000.0 -1.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P02 compound treatment 4190880.0 -930485.71428571 -1.02884768162346 -2.0917 -0.9944 3071118 PK04_108300 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 4607840.0 -1210000.0 -1.33 4256800.0 -1260000.0 -1.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P03 compound treatment 4132280.0 -989085.71428571 -1.0936423079326 -2.3593 -0.9897 3188806 PK04_108301 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccccc5)C(C)(C)C4CC3 4395360.0 -1420000.0 -1.56 4091440.0 -1430000.0 -1.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P04 compound treatment 4071360.0 -1050005.71428571 -1.16100218224579 -2.192 -0.9596 3071120 PK04_108302 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(C)C3=O 4209640.0 -1610000.0 -1.76 4649920.0 -869000.0 -0.87 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P05 compound treatment 4663120.0 -458245.71428571 -0.506687027558142 -1.6541 -0.8924 3188807 PK04_108303 COc1ccc(cc1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 4335680.0 -1480000.0 -1.63 4788760.0 -730000.0 -0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P06 compound treatment 4128080.0 -993285.71428571 -1.09828629138821 -2.2739 -0.9863 3188808 PK04_108304 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 4345040.0 -1470000.0 -1.61 4298320.0 -1220000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P07 compound treatment 4259480.0 -861885.71428571 -0.952995951848602 -2.182 -0.9758 3071124 PK04_108305 COc1cccc(c1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 4327480.0 -1490000.0 -1.63 4331360.0 -1190000.0 -1.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P08 compound treatment 4436040.0 -685325.71428571 -0.757771733057789 -1.7137 -0.9834 3188923 PK04_108306 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 4720240.0 -1100000.0 -1.2 4516440.0 -1000000.0 -1.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P09 compound treatment 3907240.0 -1214125.71428571 -1.34247136432524 -2.3657 -0.9999 3188924 PK04_108307 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(Br)cc5)C(C)(C)C4CC3 4554320.0 -1270000.0 -1.39 4154920.0 -1360000.0 -1.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P10 compound treatment 3944920.0 -1176445.71428571 -1.3008081984664 -2.3964 -0.9921 3071127 PK04_108308 OC[C@H]1C(=C(COc2ccccc2)Cn3n1c(=O)n(c4ccccc4)c3=O)[C@H](O)CCc5ccccc5 4334280.0 -1490000.0 -1.63 4300440.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P11 mock treatment 4298840.0 -822525.71428571 -0.909475192607514 -1.4887 -0.9981 5101440.0 -718000.0 -0.79 4640000.0 -879000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P12 mock treatment 3407160.0 -1714205.71428571 -1.89541499443914 -2.6081 -0.9667 4300120.0 -1520000.0 -1.66 4564960.0 -954000.0 -0.96 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P13 compound treatment 4138440.0 -982925.71428571 -1.08683113219772 -1.9675 -0.959 3188925 PK04_108309 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(N)cc5)C(C)(C)C4CC3 4386800.0 -1430000.0 -1.57 4770200.0 -749000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P14 compound treatment 4390200.0 -731165.71428571 -0.808457495344665 -1.947 -0.9763 3071425 PK04_108310 CCCC[C@@H](O)C1=C(C)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 4525880.0 -1290000.0 -1.42 4376480.0 -1140000.0 -1.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P15 compound treatment 3863920.0 -1257445.71428571 -1.39037073653876 -1.8313 -0.9738 3188926 PK04_108311 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(nc5)C(F)(F)F)C(C)(C)C4CC3 5089120.0 -731000.0 -0.8 4541360.0 -978000.0 -0.98 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P16 compound treatment 3923920.0 -1197445.71428571 -1.32402811574442 -2.304 -0.998 3215868 PK04_108312 CCCC[C@@H](O)C1=C(COC)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 4507600.0 -1310000.0 -1.44 4294000.0 -1230000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P17 compound treatment 3814800.0 -1306565.71428571 -1.44468322876239 -2.182 -0.994 3188927 PK04_108313 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)F)C(=O)N(C)c3ccccc32 4807000.0 -1010000.0 -1.11 4298040.0 -1220000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P18 compound treatment 3810160.0 -1311205.71428571 -1.44981372477049 -2.2726 -0.9945 3215866 PK04_108314 CCCC[C@@H](O)C1=C(COc2ccccc2)Cn3n([C@H]1CO)c(=O)n(c4ccccc4)c3=O 4793920.0 -1030000.0 -1.12 4161080.0 -1360000.0 -1.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P19 compound treatment 3751040.0 -1370325.71428571 -1.51518332045984 -2.5431 -0.9731 3071435 PK04_108315 COC(=O)C[C@H]1O[C@@]2(C[C@@H]1[Si](C)(C)C)C(=O)N(C)c3ccccc32 4113720.0 -1710000.0 -1.87 4501680.0 -1020000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P20 compound treatment 3647080.0 -1474285.71428571 -1.6301329680895 -2.0484 -0.9265 3071437 PK04_108316 OB1OC(CCc2ccccc2)CC=C1 4539880.0 -1280000.0 -1.4 5004880.0 -514000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P21 compound treatment 3585640.0 -1535725.71428571 -1.69806781178291 -2.511 -0.9839 3188929 PK04_108317 COC(=O)C/C=C/C[C@]1(O)C(=O)N(C)c2ccccc21 4389760.0 -1430000.0 -1.57 4438040.0 -1080000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P22 compound treatment 3742720.0 -1378645.71428571 -1.52438283054332 -2.3909 -0.9861 3071483 PK04_108318 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)c2ccncc2)c3ccccc3)c1 4391600.0 -1430000.0 -1.56 4470280.0 -1050000.0 -1.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P23 compound treatment 3576440.0 -1544925.71428571 -1.70824034697137 -2.8125 -0.9842 3188930 PK04_108319 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO[Si](C(C)C)(C(C)C)C(C)C)nn2)/C=C/C 4055280.0 -1760000.0 -1.93 4292760.0 -1230000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.2108 P24 compound treatment 3241080.0 -1880285.71428571 -2.07905136879787 -3.5633 -0.9977 3071486 PK04_108320 CC(=O)OC(C/C=C\B1OC(C)(C)C(C)(C)O1)c2ccccc2 3795800.0 -2020000.0 -2.22 3649560.0 -1870000.0 -1.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A01 mock treatment 3813920.0 -559911.45833333 -0.619099892643571 -1.7631 -0.961 3904560.0 -1020000.0 -1.12 3670920.0 -1310000.0 -1.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A02 mock treatment 4231960.0 -141871.45833333 -0.15686873936247 -0.8885 -0.8966 4264640.0 -663000.0 -0.73 4326960.0 -654000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A03 mock treatment 4209760.0 -164071.45833333 -0.181415509056376 -1.1379 -0.8901 4101920.0 -825000.0 -0.9 4098600.0 -882000.0 -0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A04 mock treatment 4336600.0 -37231.4583333302 -0.0411672086971402 -0.6097 -0.8454 4426000.0 -501000.0 -0.55 4516800.0 -464000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A05 mock treatment 4092680.0 -281151.45833333 -0.310872076433066 -0.715 -0.9835 4530240.0 -397000.0 -0.43 4490000.0 -491000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A06 mock treatment 4357360.0 -16471.4583333302 -0.0182126619022984 -0.3583 -0.8385 4670760.0 -257000.0 -0.28 4660600.0 -320000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A07 mock treatment 4347120.0 -26711.4583333302 -0.0295351358511992 -0.4806 -0.8449 4573560.0 -354000.0 -0.39 4566920.0 -414000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A08 mock treatment 4691480.0 317648.54166667 0.351227279094452 0.1511 0.2956 5123000.0 196000.0 0.21 4678280.0 -303000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A09 mock treatment 4308280.0 -65551.4583333302 -0.0724809257120689 -0.3801 -0.8921 4704080.0 -223000.0 -0.24 4640760.0 -340000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A10 mock treatment 4439400.0 65568.5416666698 0.0724998149304964 -0.2558 -0.6848 4715840.0 -212000.0 -0.23 4698000.0 -283000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A11 mock treatment 4263720.0 -110111.45833333 -0.121751378755332 -0.436 -0.6617 4336240.0 -591000.0 -0.65 4994840.0 14000.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A12 mock treatment 4702480.0 328648.54166667 0.363390092906748 0.0419 0.085 4964440.0 37000.0 0.04 4650720.0 -330000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A13 mock treatment 4614040.0 240208.54166667 0.26560106985589 -0.2224 -0.4171 4601520.0 -326000.0 -0.36 4688000.0 -293000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A14 mock treatment 4406880.0 33048.5416666698 0.0365421144599639 0.223 0.4378 4800480.0 -127000.0 -0.14 5467800.0 487000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A15 mock treatment 4631960.0 258128.54166667 0.285415399266466 -0.0722 -0.1757 4704320.0 -223000.0 -0.24 4815320.0 -166000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A16 mock treatment 4360760.0 -13071.4583333302 -0.0144532467239525 -0.3407 -0.7248 4816040.0 -111000.0 -0.12 4528760.0 -452000.0 -0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A17 mock treatment 4145160.0 -228671.45833333 -0.252844397444949 -0.2407 -0.7665 4946560.0 19200.0 0.02 4796480.0 -184000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A18 mock treatment 4212080.0 -161751.45833333 -0.178850261052328 -0.2806 -0.93 4716760.0 -211000.0 -0.23 4904600.0 -76300.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A19 mock treatment 4270200.0 -103631.45833333 -0.114586375709544 -0.4662 -0.8848 4712000.0 -215000.0 -0.24 4525520.0 -455000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A20 mock treatment 4163240.0 -210591.45833333 -0.232853154378921 -0.3532 -0.7269 4540160.0 -387000.0 -0.42 5025840.0 45000.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A21 mock treatment 4022520.0 -351311.45833333 -0.388448714348581 -0.4054 -0.8018 4936280.0 8880.0 0.01 4658640.0 -322000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A22 mock treatment 4078280.0 -295551.45833333 -0.326794305423707 -0.3104 -0.5878 5081040.0 154000.0 0.17 4603160.0 -378000.0 -0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A23 mock treatment 4084760.0 -289071.45833333 -0.319629302377918 -0.4725 -0.5594 5150240.0 223000.0 0.24 4240640.0 -740000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base A24 mock treatment 3787680.0 -586151.45833333 -0.648113732137629 -1.7751 -0.9661 3747480.0 -1180000.0 -1.29 3850640.0 -1130000.0 -1.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B01 mock treatment 4075160.0 -298671.45833333 -0.330244121705013 -0.7219 -0.9885 4487760.0 -440000.0 -0.48 4543720.0 -437000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B02 mock treatment 4391160.0 17328.5416666698 0.0191603478118467 -0.1219 -0.3142 5049200.0 122000.0 0.13 4618560.0 -362000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B03 mock treatment 4669360.0 295528.54166667 0.326768966228272 -0.0301 -0.0712 4768520.0 -159000.0 -0.17 4776600.0 -204000.0 -0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B04 mock treatment 4456160.0 82328.5416666698 0.0910315203390488 -0.0204 -0.1514 4897440.0 -30000.0 -0.03 4887680.0 -93200.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B05 mock treatment 4780320.0 406488.54166667 0.449458586283939 0.108 0.1459 5167680.0 240000.0 0.26 4457160.0 -524000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B06 mock treatment 4549440.0 175608.54166667 0.194172181467317 0.3647 0.8741 5257360.0 330000.0 0.36 5056720.0 75900.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B07 mock treatment 4511440.0 137608.54166667 0.152155188297568 0.2203 0.6396 5201880.0 274000.0 0.3 4909880.0 -71000.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B08 mock treatment 4735840.0 362008.54166667 0.400276590068401 0.6851 0.9622 5411560.0 484000.0 0.53 5236040.0 255000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B09 mock treatment 5165840.0 792008.54166667 0.875732039094507 0.8387 0.8084 5434960.0 508000.0 0.56 5001920.0 21100.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B10 mock treatment 4886760.0 512928.54166667 0.567150395573099 0.7749 0.8949 5512080.0 585000.0 0.64 5115120.0 134000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B11 mock treatment 4832400.0 458568.54166667 0.507043981133426 1.0092 0.9452 5277000.0 350000.0 0.38 5835840.0 855000.0 0.86 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B12 mock treatment 4724200.0 350368.54166667 0.387406121634299 0.5419 0.9748 5124760.0 197000.0 0.22 5314680.0 334000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B13 mock treatment 4527120.0 153288.54166667 0.169492726531822 0.3515 0.8394 5272520.0 345000.0 0.38 5041960.0 61100.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B14 mock treatment 4834160.0 460328.54166667 0.508990031343393 0.734 0.9661 5168120.0 241000.0 0.26 5477800.0 497000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B15 mock treatment 4938360.0 564528.54166667 0.624205049456231 0.9311 0.9708 5510400.0 583000.0 0.64 5329600.0 349000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B16 mock treatment 4657840.0 284008.54166667 0.314031183035758 0.5651 0.9318 5089040.0 162000.0 0.18 5466840.0 486000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B17 mock treatment 4314040.0 -59791.4583333302 -0.0661120341158122 0.2767 0.6934 5227160.0 300000.0 0.33 5197200.0 216000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B18 mock treatment 4826280.0 452448.54166667 0.500277033812403 0.5839 0.9263 5077800.0 150000.0 0.16 5325960.0 345000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B19 mock treatment 4966080.0 592248.54166667 0.654855340263217 0.5204 0.7673 5022400.0 95000.0 0.1 5122840.0 142000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B20 mock treatment 3777240.0 -596591.45833333 -0.659657348155845 0.2903 0.2701 5321560.0 394000.0 0.43 5709080.0 728000.0 0.73 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B21 mock treatment 4234280.0 -139551.45833333 -0.154303491358422 -0.4729 -0.9527 4649760.0 -278000.0 -0.3 4621360.0 -360000.0 -0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B22 mock treatment 5027040.0 653208.54166667 0.722259442990267 0.3055 0.4127 4896640.0 -30800.0 -0.03 4822080.0 -159000.0 -0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B23 mock treatment 4384040.0 10208.5416666698 0.0112876901442516 -0.0578 -0.5891 4913600.0 -13800.0 -0.02 4884880.0 -96000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base B24 mock treatment 4177440.0 -196391.45833333 -0.217152067457594 -1.0945 -0.892 4304600.0 -623000.0 -0.68 3987800.0 -993000.0 -1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C01 mock treatment 4465800.0 91968.5416666698 0.101690568080006 -0.3269 -0.5971 4456240.0 -471000.0 -0.52 4829560.0 -151000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C02 mock treatment 4727160.0 353328.54166667 0.390679024260153 -0.0117 -0.024 4713160.0 -214000.0 -0.23 4805080.0 -176000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C03 mock treatment 5394960.0 1021128.54166667 1.12907239370116 1.4663 0.9728 5601800.0 674000.0 0.74 5650560.0 670000.0 0.67 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C04 mock treatment 5493360.0 1119528.54166667 1.23787429180388 1.9389 0.9972 5900000.0 973000.0 1.07 6032440.0 1050000.0 1.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C05 mock treatment 5559840.0 1186008.54166667 1.31138191564401 1.5556 0.9402 5718840.0 791000.0 0.87 5495360.0 514000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C06 mock treatment 5402320.0 1028488.54166667 1.13721042185193 1.7566 0.95 6157080.0 1230000.0 1.35 5537480.0 557000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C07 mock treatment 5381120.0 1007288.54166667 1.1137693625046 1.608 0.989 5741560.0 814000.0 0.89 5757800.0 777000.0 0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C08 mock treatment 4878120.0 504288.54166667 0.557597058178714 1.041 0.9986 5484480.0 557000.0 0.61 5613920.0 633000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C09 mock treatment 4974120.0 600288.54166667 0.663745251449658 0.7437 0.9329 5216760.0 289000.0 0.32 5287280.0 306000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C10 mock treatment 4933480.0 559648.54166667 0.618809182964958 0.8443 0.9705 5399360.0 472000.0 0.52 5306440.0 326000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C11 mock treatment 5049720.0 675888.54166667 0.747336953650527 0.7485 0.8766 5087040.0 160000.0 0.17 5353840.0 373000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C12 mock treatment 4887920.0 514088.54166667 0.568433019575122 0.8007 0.9659 5190920.0 264000.0 0.29 5508800.0 528000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C13 mock treatment 5135560.0 761728.54166667 0.842251129800297 0.828 0.8326 4989040.0 61600.0 0.07 5503320.0 522000.0 0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C14 mock treatment 5168800.0 794968.54166667 0.879004941720361 0.541 0.6058 4855800.0 -71600.0 -0.08 5116760.0 136000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C15 mock treatment 4764880.0 391048.54166667 0.432386418532862 0.5602 0.8834 5344440.0 417000.0 0.46 5061800.0 80900.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C16 mock treatment 5022800.0 648968.54166667 0.7175712311208 0.9606 0.9437 5184200.0 257000.0 0.28 5643480.0 663000.0 0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C17 mock treatment 4706240.0 332408.54166667 0.36754756380986 0.5658 0.8617 4994320.0 66900.0 0.07 5518160.0 537000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C18 mock treatment 4965520.0 591688.54166667 0.654236142469136 0.6781 0.8888 5076480.0 149000.0 0.16 5336680.0 356000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C19 mock treatment 4687760.0 313928.54166667 0.347114036605203 0.9949 0.963 5563000.0 636000.0 0.7 5658480.0 678000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C20 mock treatment 4793440.0 419608.54166667 0.463965506030968 0.4167 0.7824 5166160.0 239000.0 0.26 4977200.0 -3660.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C21 mock treatment 4594240.0 220408.54166667 0.243708004993758 -0.0138 -0.0424 4874000.0 -53400.0 -0.06 4772400.0 -208000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C22 mock treatment 4857840.0 484008.54166667 0.535173252350227 0.0527 0.0821 4617760.0 -310000.0 -0.34 4876480.0 -104000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C23 mock treatment 4324240.0 -49591.4583333302 -0.0548337885807743 -0.0744 -0.9692 4901400.0 -26000.0 -0.03 4935480.0 -45400.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base C24 mock treatment 4279120.0 -94711.4583333302 -0.104723439418118 -0.755 -0.8801 4354880.0 -573000.0 -0.63 4406880.0 -574000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D01 mock treatment 4571880.0 198048.54166667 0.2189843216444 -0.1979 -0.4363 4667280.0 -260000.0 -0.28 4704920.0 -276000.0 -0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D02 mock treatment 4856440.0 482608.54166667 0.533625257865025 -0.1031 -0.1242 4351440.0 -576000.0 -0.63 4899720.0 -81100.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D03 mock treatment 4358960.0 -14871.4583333302 -0.0164435253477827 -0.0947 -0.4741 4969480.0 42100.0 0.05 4787840.0 -193000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D04 mock treatment 4907760.0 533928.54166667 0.590370312851118 0.7383 0.9501 5329160.0 402000.0 0.44 5228440.0 248000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D05 mock treatment 4816640.0 442808.54166667 0.489617986071446 0.6085 0.7899 5469800.0 542000.0 0.59 4951360.0 -29500.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D06 mock treatment 4419560.0 45728.5416666698 0.0505625216545011 0.2108 0.8616 5128120.0 201000.0 0.22 5075240.0 94400.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D07 mock treatment 4703640.0 329808.54166667 0.364672716908772 0.1827 0.493 4942000.0 14600.0 0.02 4916920.0 -63900.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D08 mock treatment 4655360.0 281528.54166667 0.311289021376259 0.8862 0.8287 5133520.0 206000.0 0.23 5975240.0 994000.0 1.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D09 mock treatment 4925240.0 551408.54166667 0.609698129709202 0.4392 0.6952 4914800.0 -12600.0 -0.01 5145040.0 164000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D10 mock treatment 4628960.0 255128.54166667 0.282098268226749 0.5833 0.9394 5390360.0 463000.0 0.51 5201360.0 220000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D11 mock treatment 3832640.0 -541191.45833333 -0.598400994955737 -0.1579 -0.2314 5226880.0 299000.0 0.33 4977800.0 -3060.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D12 mock treatment 4987840.0 614008.54166667 0.678915597404631 0.9071 0.97 5254080.0 327000.0 0.36 5513440.0 533000.0 0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D13 mock treatment 4882080.0 508248.54166667 0.56197567115114 0.7192 0.8543 5497200.0 570000.0 0.62 5040440.0 59600.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D14 mock treatment 4796960.0 423128.54166667 0.467857606450902 0.774 0.9971 5360600.0 433000.0 0.47 5377840.0 397000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D15 mock treatment 5047040.0 673208.54166667 0.744373649921713 1.0128 0.8604 5022200.0 94800.0 0.1 5883600.0 903000.0 0.91 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D16 mock treatment 5093720.0 719888.54166667 0.79598820889971 1.0681 0.9563 5252520.0 325000.0 0.36 5676400.0 696000.0 0.7 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D17 mock treatment 5138000.0 764168.54166667 0.844949063045933 1.1205 0.9433 5226840.0 299000.0 0.33 5746080.0 765000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D18 mock treatment 4833520.0 459688.54166667 0.508282376721587 0.8245 0.8861 5070080.0 143000.0 0.16 5741680.0 761000.0 0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D19 mock treatment 5094760.0 720928.54166667 0.797138147660145 0.6739 0.7413 4870360.0 -57000.0 -0.06 5411880.0 431000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D20 mock treatment 4642080.0 268248.54166667 0.296605187973778 0.5179 0.9991 5187840.0 260000.0 0.29 5295000.0 314000.0 0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D21 mock treatment 4389480.0 15648.5416666698 0.0173027544296051 0.2314 0.5135 4870400.0 -57000.0 -0.06 5425120.0 444000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D22 mock treatment 4669960.0 296128.54166667 0.327432392436215 0.4509 0.8897 4994840.0 67400.0 0.07 5359240.0 378000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D23 mock treatment 4776640.0 402808.54166667 0.445389572208552 0.2617 0.5701 5002840.0 75400.0 0.08 4906480.0 -74400.0 -0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base D24 mock treatment 4232280.0 -141551.45833333 -0.156514912051567 -0.4077 -0.7478 4901720.0 -25700.0 -0.03 4461280.0 -520000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E01 mock treatment 4713640.0 339808.54166667 0.375729820374495 0.1241 0.2725 5002800.0 75400.0 0.08 4738320.0 -243000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E02 mock treatment 4977200.0 603368.54166667 0.667150839317101 0.4754 0.5663 5319920.0 393000.0 0.43 4708280.0 -273000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E03 mock treatment 4629000.0 255168.54166667 0.282142496640612 0.2754 0.7901 4918600.0 -8800.0 -0.01 5184720.0 204000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E04 mock treatment 4106520.0 -267311.45833333 -0.295569045236504 -0.4514 -0.9948 4694400.0 -233000.0 -0.26 4750520.0 -230000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E05 mock treatment 4901240.0 527408.54166667 0.583161081391466 0.7175 0.8703 5454120.0 527000.0 0.58 5063320.0 82500.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E06 mock treatment 5067280.0 693448.54166667 0.766753227336338 0.6991 0.68 5523200.0 596000.0 0.65 4773240.0 -208000.0 -0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E07 mock treatment 4725360.0 351528.54166667 0.388688745636323 0.7471 0.8445 5644720.0 717000.0 0.79 5100160.0 119000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E08 mock treatment 5287000.0 913168.54166667 1.00969990468521 1.5563 0.9654 5954000.0 1030000.0 1.12 5540520.0 560000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E09 mock treatment 4856000.0 482168.54166667 0.533138745312533 0.8181 0.9957 5339640.0 412000.0 0.45 5411720.0 431000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E10 mock treatment 4552880.0 179048.54166667 0.197975825059526 0.8813 0.8898 5691240.0 764000.0 0.84 5471160.0 490000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E11 mock treatment 4629680.0 255848.54166667 0.282894379676281 0.8833 0.9517 5537080.0 610000.0 0.67 5558120.0 577000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E12 mock treatment 5287240.0 913408.54166667 1.00996527516839 1.2886 0.969 5459080.0 532000.0 0.58 5618240.0 637000.0 0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E13 mock treatment 5067400.0 693568.54166667 0.766885912577926 0.9882 0.9483 5505360.0 578000.0 0.63 5291560.0 311000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E14 mock treatment 4751720.0 377888.54166667 0.41783527037197 0.5974 0.9573 5107880.0 180000.0 0.2 5398680.0 418000.0 0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E15 mock treatment 4812640.0 438808.54166667 0.485195144685157 0.652 0.8544 4980360.0 53000.0 0.06 5564800.0 584000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E16 mock treatment 4533400.0 159568.54166667 0.176436587508296 0.6433 0.9375 5355360.0 428000.0 0.47 5448240.0 467000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E17 mock treatment 4536960.0 163128.54166667 0.180372916342094 0.4228 0.907 5063120.0 136000.0 0.15 5382720.0 402000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E18 mock treatment 4664840.0 291008.54166667 0.321771155461765 -0.5847 -0.2944 3209120.0 -1720000.0 -1.88 5526120.0 545000.0 0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E19 mock treatment 4709720.0 335888.54166667 0.371395435815931 0.4524 0.9227 5030160.0 103000.0 0.11 5279520.0 299000.0 0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E20 mock treatment 4474240.0 100408.54166667 0.111022763405077 0.6103 0.8797 5264720.0 337000.0 0.37 5555440.0 575000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E21 mock treatment 4890960.0 517128.54166667 0.571794379028702 0.6438 0.9023 5295440.0 368000.0 0.4 5120600.0 140000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E22 mock treatment 4563680.0 189848.54166667 0.209917496802507 0.1985 0.8333 5027760.0 100000.0 0.11 5004680.0 23800.0 0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E23 mock treatment 4608360.0 234528.54166667 0.259320635087359 0.0626 0.1924 4964960.0 37600.0 0.04 4789520.0 -191000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base E24 mock treatment 4339560.0 -34271.4583333302 -0.0378943060712861 -0.832 -0.8328 4215320.0 -712000.0 -0.78 4359760.0 -621000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F01 mock treatment 4367160.0 -6671.45833333023 -0.0073767005058895 -0.2325 -0.7441 4656920.0 -270000.0 -0.3 4882160.0 -98700.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F02 mock treatment 4795400.0 421568.54166667 0.46613269831025 0.2353 0.5028 4894560.0 -32800.0 -0.04 4958400.0 -22500.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F03 mock treatment 4653800.0 279968.54166667 0.309564113235606 0.4437 0.8582 5303000.0 376000.0 0.41 5028320.0 47500.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F04 mock treatment 4774680.0 400848.54166667 0.443222379929271 0.301 0.6739 4960840.0 33400.0 0.04 5022200.0 41300.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F05 mock treatment 4863720.0 489888.54166667 0.541674829188072 0.7971 0.8543 5616800.0 689000.0 0.75 5064480.0 83600.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F06 mock treatment 4680400.0 306568.54166667 0.33897600845443 0.8262 0.979 5405040.0 478000.0 0.52 5547800.0 567000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F07 mock treatment 4402520.0 28688.5416666698 0.0317212173489085 0.2655 0.8656 5098440.0 171000.0 0.19 5220760.0 240000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F08 mock treatment 5025520.0 651688.54166667 0.720578763263477 0.793 0.8813 5404880.0 477000.0 0.52 5110400.0 130000.0 0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F09 mock treatment 5217520.0 843688.54166667 0.932875149805366 1.0374 0.9193 5433760.0 506000.0 0.55 5289120.0 308000.0 0.31 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F10 mock treatment 4639040.0 265208.54166667 0.293243828520198 0.9736 0.9304 5436320.0 509000.0 0.56 5813720.0 833000.0 0.84 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F11 mock treatment 4738280.0 364448.54166667 0.402974523314037 0.8817 0.9678 5562680.0 635000.0 0.7 5407720.0 427000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F12 mock treatment 5088120.0 714288.54166667 0.789796230958905 0.8608 0.8671 5027760.0 100000.0 0.11 5570040.0 589000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F13 mock treatment 5044800.0 670968.54166667 0.741896858745391 0.7836 0.7916 4891960.0 -35400.0 -0.04 5632640.0 652000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F14 mock treatment 5532680.0 1158848.54166667 1.2813508226311 1.1089 0.8151 5175560.0 248000.0 0.27 5347040.0 366000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F15 mock treatment 4083600.0 -290231.45833333 -0.320911926379942 0.2587 0.4098 5281200.0 354000.0 0.39 5361120.0 380000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F16 mock treatment 4591240.0 217408.54166667 0.240390873954041 0.7299 0.9307 5512360.0 585000.0 0.64 5362760.0 382000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F17 mock treatment 4844840.0 471008.54166667 0.520799017844786 0.8953 0.9672 5245920.0 319000.0 0.35 5659440.0 679000.0 0.68 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F18 mock treatment 5103160.0 729328.54166667 0.806426114571353 1.0654 0.9675 5498600.0 571000.0 0.63 5392680.0 412000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F19 mock treatment 4751240.0 377408.54166667 0.417304529405615 0.5297 0.9047 5020960.0 93600.0 0.1 5377200.0 396000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F20 mock treatment 4675680.0 301848.54166667 0.333757055618609 0.7481 0.9873 5362760.0 435000.0 0.48 5464320.0 483000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F21 mock treatment 4559960.0 186128.54166667 0.205804254313258 0.4045 0.9926 5176520.0 249000.0 0.27 5202000.0 221000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F22 mock treatment 4998680.0 624848.54166667 0.690901497561475 0.7441 0.9101 5128480.0 201000.0 0.22 5357200.0 376000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F23 mock treatment 4941520.0 567688.54166667 0.6276990941514 0.463 0.6549 5201400.0 274000.0 0.3 4855480.0 -125000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base F24 mock treatment 4275120.0 -98711.4583333302 -0.109146280804408 -0.7326 -0.86 4529040.0 -398000.0 -0.44 4260000.0 -721000.0 -0.72 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G01 mock treatment 4234640.0 -139191.45833333 -0.153905435633656 -0.2926 -0.6122 5010000.0 82600.0 0.09 4539040.0 -442000.0 -0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G02 mock treatment 4970920.0 597088.54166667 0.660206978340627 0.8389 0.8179 5644200.0 717000.0 0.78 4988680.0 7820.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G03 mock treatment 4669480.0 295648.54166667 0.326901651469861 0.0524 0.1149 4645160.0 -282000.0 -0.31 5053480.0 72600.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G04 mock treatment 4677280.0 303448.54166667 0.335526192173125 0.6524 0.9944 5321120.0 394000.0 0.43 5342800.0 362000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G05 mock treatment 4760800.0 386968.54166667 0.427875120318847 0.7988 0.9885 5289320.0 362000.0 0.4 5538200.0 557000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G06 mock treatment 4829840.0 456008.54166667 0.504213362646201 1.0453 0.9901 5469120.0 542000.0 0.59 5691320.0 710000.0 0.71 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G07 mock treatment 4956640.0 582808.54166667 0.644417434591574 1.081 0.9635 5681240.0 754000.0 0.83 5381760.0 401000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G08 mock treatment 5026800.0 652968.54166667 0.721994072507089 1.3174 0.9994 5640640.0 713000.0 0.78 5756840.0 776000.0 0.78 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G09 mock treatment 4825000.0 451168.54166667 0.498861724568791 1.0978 0.8725 5950160.0 1020000.0 1.12 5262320.0 281000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G10 mock treatment 5284280.0 910448.54166667 1.00669237254254 1.4062 0.9772 5456680.0 529000.0 0.58 5827080.0 846000.0 0.85 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G11 mock treatment 5015760.0 641928.54166667 0.70978703028093 1.2813 0.988 5489640.0 562000.0 0.62 5871400.0 891000.0 0.89 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G12 mock treatment 4919040.0 545208.54166667 0.602842725560454 1.4161 0.8028 5114440.0 187000.0 0.2 6620040.0 1640000.0 1.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G13 mock treatment 5278920.0 905088.54166667 1.00076576508491 1.5082 0.9867 5539720.0 612000.0 0.67 5918520.0 938000.0 0.94 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G14 mock treatment 4656680.0 282848.54166667 0.312748559033735 0.6814 0.9809 5383080.0 456000.0 0.5 5348000.0 367000.0 0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G15 mock treatment 4810840.0 437008.54166667 0.483204866061327 0.8879 0.9965 5367200.0 440000.0 0.48 5551920.0 571000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G16 mock treatment 4212920.0 -160911.45833333 -0.177921464361207 0.4599 0.6236 5247400.0 320000.0 0.35 5602680.0 622000.0 0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G17 mock treatment 4744560.0 370728.54166667 0.409918384290512 0.7784 0.9975 5338960.0 412000.0 0.45 5466760.0 486000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G18 mock treatment 5048240.0 674408.54166667 0.7457005023376 0.8473 0.9139 5123080.0 196000.0 0.21 5486560.0 506000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G19 mock treatment 5365880.0 992048.54166667 1.09691833682284 0.9803 0.8324 5165520.0 238000.0 0.26 5319840.0 339000.0 0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G20 mock treatment 4526800.0 152968.54166667 0.169138899220919 0.7358 0.8944 5307360.0 380000.0 0.42 5667600.0 687000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G21 mock treatment 4903520.0 529688.54166667 0.585682100981651 0.8383 0.983 5261480.0 334000.0 0.37 5479440.0 499000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G22 mock treatment 4961120.0 587288.54166667 0.649371016944218 0.6464 0.872 5227080.0 300000.0 0.33 5122400.0 142000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G23 mock treatment 4726960.0 353128.54166667 0.390457882190839 -0.0662 -0.1035 4928640.0 1240.0 0.0 4476160.0 -505000.0 -0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base G24 mock treatment 4506920.0 133088.54166667 0.147157377531061 -0.2397 -0.5418 4752160.0 -175000.0 -0.19 4611760.0 -369000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H01 mock treatment 4540520.0 166688.54166667 0.184309245175891 -0.0167 -0.046 5006520.0 79100.0 0.09 4682080.0 -299000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H02 mock treatment 4539600.0 165768.54166667 0.183291991657045 0.0854 0.2355 5112480.0 185000.0 0.2 4743600.0 -237000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H03 mock treatment 4697840.0 324008.54166667 0.358259596898652 0.2961 0.7017 4872560.0 -54800.0 -0.06 5194720.0 214000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H04 mock treatment 4659160.0 285328.54166667 0.315490720693234 1.1089 0.9329 5762720.0 835000.0 0.91 5668880.0 688000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H05 mock treatment 4712560.0 338728.54166667 0.374535653200197 0.5925 0.9806 5297000.0 370000.0 0.4 5226920.0 246000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H06 mock treatment 4784680.0 410848.54166667 0.454279483394994 0.6492 0.9585 5341120.0 414000.0 0.45 5197160.0 216000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H07 mock treatment 4446040.0 72208.5416666698 0.0798417316317367 0.7993 0.8434 5653480.0 726000.0 0.8 5488520.0 508000.0 0.51 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H08 mock treatment 5166400.0 792568.54166667 0.876351236888588 1.0585 0.9559 5354160.0 427000.0 0.47 5468760.0 488000.0 0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H09 mock treatment 4712440.0 338608.54166667 0.374402967958608 0.7159 0.9302 5502400.0 575000.0 0.63 5215920.0 235000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H10 mock treatment 4893720.0 519888.54166667 0.574846139585242 0.6806 0.9497 5220680.0 293000.0 0.32 5262640.0 282000.0 0.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H11 mock treatment 4523080.0 149248.54166667 0.16502565673167 0.6778 0.9255 5394840.0 467000.0 0.51 5476120.0 495000.0 0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H12 mock treatment 4774320.0 400488.54166667 0.442824324204505 1.0822 0.9784 5548200.0 621000.0 0.68 5729920.0 749000.0 0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H13 mock treatment 4841360.0 467528.54166667 0.516951145838714 0.9534 0.9514 5642840.0 715000.0 0.78 5330560.0 350000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H14 mock treatment 4806080.0 432248.54166667 0.477941684811642 0.9239 0.9504 5249480.0 322000.0 0.35 5747640.0 767000.0 0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H15 mock treatment 4638160.0 264328.54166667 0.292270803415215 0.2877 0.7646 4900760.0 -26600.0 -0.03 5215280.0 234000.0 0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H16 mock treatment 4901200.0 527368.54166667 0.583116852977603 0.8955 0.9853 5454760.0 527000.0 0.58 5369960.0 389000.0 0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H17 mock treatment 4854160.0 480328.54166667 0.53110423827484 0.7628 0.9893 5299880.0 372000.0 0.41 5361720.0 381000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H18 mock treatment 4654960.0 281128.54166667 0.31084673723763 0.4063 0.6351 4793440.0 -134000.0 -0.15 5518520.0 538000.0 0.54 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H19 mock treatment 5018760.0 644928.54166667 0.713104161320648 0.9508 0.96 5230280.0 303000.0 0.33 5580720.0 600000.0 0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H20 mock treatment 4992520.0 618688.54166667 0.684090321826589 0.8366 0.9565 5320040.0 393000.0 0.43 5314640.0 334000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H21 mock treatment 4607360.0 233528.54166667 0.258214924740787 0.5683 0.769 4958880.0 31500.0 0.03 5669960.0 689000.0 0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H22 mock treatment 4529240.0 155408.54166667 0.171836832466555 -0.1711 -0.405 4841680.0 -85700.0 -0.09 4607840.0 -373000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H23 mock treatment 5029720.0 655888.54166667 0.72522274671908 0.1976 0.2536 4809400.0 -118000.0 -0.13 4727960.0 -253000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base H24 mock treatment 4260800.0 -113031.45833333 -0.124980052967324 -0.7671 -0.8526 4207760.0 -720000.0 -0.79 4566840.0 -414000.0 -0.42 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I01 mock treatment 4142960.0 -230871.45833333 -0.255276960207408 -0.6401 -0.9373 4662160.0 -265000.0 -0.29 4420000.0 -561000.0 -0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I02 mock treatment 4540600.0 166768.54166667 0.184397702003617 0.165 0.7993 4935680.0 8280.0 0.01 5072800.0 91900.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I03 mock treatment 4030480.0 -343351.45833333 -0.379647259989865 -0.089 -0.2154 5007160.0 79800.0 0.09 5118440.0 138000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I04 mock treatment 4385280.0 11448.5416666698 0.0126587709740013 -0.0882 -0.6055 4907320.0 -20100.0 -0.02 4838000.0 -143000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I05 mock treatment 4224200.0 -149631.45833333 -0.165449051651871 0.0122 0.0417 5143160.0 216000.0 0.24 4931360.0 -49500.0 -0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I06 mock treatment 3126560.0 -1247271.45833333 -1.37912095646354 -0.316 -0.2086 5167080.0 240000.0 0.26 5548120.0 567000.0 0.57 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I07 mock treatment 4471560.0 97728.5416666698 0.108059459676263 0.1149 0.2004 5330280.0 403000.0 0.44 4631920.0 -349000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I08 mock treatment 4481960.0 108128.54166667 0.119558847280615 0.3951 0.7959 5359240.0 432000.0 0.47 5072320.0 91500.0 0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I09 mock treatment 4718160.0 344328.54166667 0.380727631141002 0.7774 0.994 5381240.0 454000.0 0.5 5447920.0 467000.0 0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I10 mock treatment 4561560.0 187728.54166667 0.207573390867773 0.7312 0.9344 5470760.0 543000.0 0.6 5443080.0 462000.0 0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I11 mock treatment 4766680.0 392848.54166667 0.434376697156692 0.8748 0.9804 5321920.0 395000.0 0.43 5627280.0 646000.0 0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I12 mock treatment 4710760.0 336928.54166667 0.372545374576367 0.5998 0.8609 5003720.0 76300.0 0.08 5561480.0 581000.0 0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I13 mock treatment 4579480.0 205648.54166667 0.22738772027835 0.461 0.9592 5270320.0 343000.0 0.38 5175680.0 195000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I14 mock treatment 4377800.0 3968.54166666977 0.00438805758164021 0.4521 0.8196 5261720.0 334000.0 0.37 5392000.0 411000.0 0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I15 mock treatment 4384760.0 10928.5416666698 0.0120838015937837 0.5395 0.8069 5443240.0 516000.0 0.56 5337080.0 356000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I16 mock treatment 4609560.0 235728.54166667 0.260647487503246 0.5482 0.9691 5163440.0 236000.0 0.26 5409720.0 429000.0 0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I17 mock treatment 4186400.0 -187431.45833333 -0.207244902752306 -0.1061 -0.267 4719440.0 -208000.0 -0.23 5231160.0 250000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I18 mock treatment 4120000.0 -253831.45833333 -0.280664069764709 0.0667 0.1628 5041640.0 114000.0 0.13 5250960.0 270000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I19 mock treatment 4542520.0 168688.54166667 0.186520665869036 0.1751 0.8405 5007960.0 80600.0 0.09 5009240.0 28400.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I20 mock treatment 4281080.0 -92751.4583333302 -0.102556247138837 0.3935 0.6663 5398800.0 471000.0 0.52 5247760.0 267000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I21 mock treatment 4348720.0 -25111.4583333302 -0.0277659992966835 -0.2358 -0.867 4735920.0 -191000.0 -0.21 4810520.0 -170000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I22 mock treatment 4514960.0 141128.54166667 0.156047288717502 -0.0203 -0.0716 4714480.0 -213000.0 -0.23 5022680.0 41800.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I23 mock treatment 4370920.0 -2911.45833333023 -0.0032192296027775 -0.0695 -0.7219 4842280.0 -85100.0 -0.09 4956960.0 -23900.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base I24 mock treatment 4179440.0 -194391.45833333 -0.214940646764449 -1.2823 -0.8779 3834320.0 -1090000.0 -1.2 4174760.0 -806000.0 -0.81 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J01 mock treatment 3717800.0 -656031.45833333 -0.725380771156105 -0.9871 -0.9819 4476960.0 -450000.0 -0.49 4491560.0 -489000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J02 mock treatment 3542760.0 -831071.45833333 -0.918924310220127 -1.0426 -0.9369 4507160.0 -420000.0 -0.46 4555680.0 -425000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J03 mock treatment 4215080.0 -158751.45833333 -0.175533130012611 -0.6835 -0.7463 4113600.0 -814000.0 -0.89 4864160.0 -117000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J04 mock treatment 3800160.0 -573671.45833333 -0.634314467012407 0.0858 0.1015 5234840.0 307000.0 0.34 5425560.0 445000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J05 mock treatment 4132440.0 -241391.45833333 -0.266909033053349 -0.0703 -0.1746 5176920.0 250000.0 0.27 4853160.0 -128000.0 -0.13 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J06 mock treatment 4387600.0 13768.5416666698 0.0152240189780491 -0.1438 -0.731 4768320.0 -159000.0 -0.17 4891080.0 -89800.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J07 mock treatment 3955680.0 -418151.45833333 -0.462354393913476 -0.1206 -0.2044 4836480.0 -90900.0 -0.1 5332600.0 352000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J08 mock treatment 3834320.0 -539511.45833333 -0.596543401573495 -0.0516 -0.0741 5144440.0 217000.0 0.24 5249400.0 269000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J09 mock treatment 4304160.0 -69671.4583333302 -0.077036452339947 0.166 0.5978 5049440.0 122000.0 0.13 5210920.0 230000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J10 mock treatment 4145320.0 -228511.45833333 -0.252667483789497 -0.2014 -0.408 4613120.0 -314000.0 -0.34 5227920.0 247000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J11 mock treatment 3821840.0 -551991.45833333 -0.610342666698718 0.0107 0.0138 5326920.0 400000.0 0.44 5171560.0 191000.0 0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J12 mock treatment 4649640.0 275808.54166667 0.304964358193865 0.4954 0.9872 5130440.0 203000.0 0.22 5310360.0 329000.0 0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J13 mock treatment 4838240.0 464408.54166667 0.513501329557409 0.7265 0.928 5094480.0 167000.0 0.18 5540800.0 560000.0 0.56 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J14 mock treatment 4421520.0 47688.5416666698 0.0527297139337829 0.3518 0.8509 5107200.0 180000.0 0.2 5339240.0 358000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J15 mock treatment 4879240.0 505408.54166667 0.558835453766875 0.6743 0.9081 5354840.0 427000.0 0.47 5121320.0 140000.0 0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J16 mock treatment 4460040.0 86208.5416666698 0.0953216764837495 0.1897 0.6018 4871720.0 -55700.0 -0.06 5274040.0 293000.0 0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J17 mock treatment 4453200.0 79368.5416666698 0.0877586177131947 0.2876 0.6918 5298440.0 371000.0 0.41 4984880.0 4020.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J18 mock treatment 4481600.0 107768.54166667 0.119160791555849 0.1995 0.4465 5288960.0 362000.0 0.4 4811960.0 -169000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J19 mock treatment 4529080.0 155248.54166667 0.171659918811104 0.1204 0.3455 4749080.0 -178000.0 -0.2 5212280.0 231000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J20 mock treatment 4336320.0 -37511.4583333302 -0.0414768075941805 0.2107 0.4791 4899640.0 -27800.0 -0.03 5416160.0 435000.0 0.44 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J21 mock treatment 4341360.0 -32471.4583333302 -0.0359040274474559 0.0108 0.1857 4968160.0 40800.0 0.04 4990800.0 9940.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J22 mock treatment 4530400.0 156568.54166667 0.173119456468579 -0.1796 -0.354 4920680.0 -6720.0 -0.01 4505720.0 -475000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J23 mock treatment 4575240.0 201408.54166667 0.222699508408883 -0.1172 -0.2901 4830920.0 -96500.0 -0.11 4662000.0 -319000.0 -0.32 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base J24 mock treatment 3927400.0 -446431.45833333 -0.493623882514542 -1.096 -0.9798 4379360.0 -548000.0 -0.6 4179240.0 -802000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K01 mock treatment 4084880.0 -288951.45833333 -0.31949661713633 -0.9876 -0.8826 4016560.0 -911000.0 -1.0 4588720.0 -392000.0 -0.39 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K02 mock treatment 4092960.0 -280871.45833333 -0.310562477536025 -0.2486 -0.569 4681840.0 -246000.0 -0.27 5129160.0 148000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K03 mock treatment 4177280.0 -196551.45833333 -0.217328981113045 -0.4428 -0.8265 4868840.0 -58600.0 -0.06 4497160.0 -484000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K04 mock treatment 3861760.0 -512071.45833333 -0.56620270966355 -0.1522 -0.2192 5285000.0 358000.0 0.39 4892160.0 -88700.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K05 mock treatment 4196960.0 -176871.45833333 -0.195568601492502 7.0E-4 0.0015 5270880.0 343000.0 0.38 4802120.0 -179000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K06 mock treatment 4332240.0 -41591.4583333302 -0.0459881058081956 0.4355 0.6733 5492800.0 565000.0 0.62 5161280.0 180000.0 0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K07 mock treatment 4287920.0 -85911.4583333302 -0.0949931883682818 0.171 0.4734 5242920.0 316000.0 0.35 5026360.0 45500.0 0.05 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K08 mock treatment 4269080.0 -104751.45833333 -0.115824771297705 0.0375 0.0768 5304400.0 377000.0 0.41 4749520.0 -231000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K09 mock treatment 4207360.0 -166471.45833333 -0.18406921388815 0.1181 0.2811 4937680.0 10300.0 0.01 5356800.0 376000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K10 mock treatment 4378840.0 5008.54166666977 0.00553799634207544 -0.127 -0.522 4943040.0 15600.0 0.02 4739080.0 -242000.0 -0.24 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K11 mock treatment 4219320.0 -154511.45833333 -0.170844918143144 0.3214 0.5109 5053440.0 126000.0 0.14 5568320.0 587000.0 0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K12 mock treatment 4178800.0 -195031.45833333 -0.215648301386256 0.2744 0.5078 5189280.0 262000.0 0.29 5383600.0 403000.0 0.4 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K13 mock treatment 4065640.0 -308191.45833333 -0.340770484204382 0.2225 0.3147 5035240.0 108000.0 0.12 5586680.0 606000.0 0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K14 mock treatment 4375920.0 2088.54166666977 0.00230932213008421 0.2563 0.8194 5117280.0 190000.0 0.21 5213680.0 233000.0 0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K15 mock treatment 4401920.0 28088.5416666698 0.0310577911409651 0.1183 0.4159 5171280.0 244000.0 0.27 4888040.0 -92800.0 -0.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K16 mock treatment 4421600.0 47768.5416666698 0.0528181707615087 0.1549 0.9356 5050000.0 123000.0 0.13 5061840.0 81000.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K17 mock treatment 4063720.0 -310111.45833333 -0.3428934480698 -0.3589 -0.7631 4635720.0 -292000.0 -0.32 5021320.0 40500.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K18 mock treatment 4038880.0 -334951.45833333 -0.370359293078657 -0.194 -0.5078 4884840.0 -42600.0 -0.05 5061560.0 80700.0 0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K19 mock treatment 4233640.0 -140191.45833333 -0.155011145980228 -0.2443 -0.7823 4679800.0 -248000.0 -0.27 4983800.0 2940.0 0.0 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K20 mock treatment 4085720.0 -288111.45833333 -0.318567820445209 -0.0841 -0.2243 4906360.0 -21000.0 -0.02 5176160.0 195000.0 0.2 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K21 mock treatment 4404600.0 30768.5416666698 0.0340210948697789 0.0075 0.1007 4959640.0 32200.0 0.04 4924760.0 -56100.0 -0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K22 mock treatment 3812280.0 -561551.45833333 -0.62091325761195 -0.4378 -0.6447 4698520.0 -229000.0 -0.25 5093720.0 113000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K23 mock treatment 3968000.0 -405831.45833333 -0.448732042443705 -0.7311 -0.9747 4660440.0 -267000.0 -0.29 4457600.0 -523000.0 -0.53 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base K24 mock treatment 3780400.0 -593431.45833333 -0.656163303460676 -1.2014 -0.9987 4303160.0 -624000.0 -0.68 4242480.0 -738000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L01 mock treatment 3389040.0 -984791.45833333 -1.08889410469523 -1.4709 -0.9717 4129280.0 -798000.0 -0.87 4398200.0 -583000.0 -0.58 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L02 mock treatment 3755920.0 -617911.45833333 -0.683231092744767 -0.8648 -0.9425 4689880.0 -238000.0 -0.26 4428320.0 -553000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L03 mock treatment 3959960.0 -413871.45833333 -0.457621953630147 -0.2048 -0.4373 4930240.0 2840.0 0.0 5080240.0 99400.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L04 mock treatment 4031240.0 -342591.45833333 -0.37880692012647 -0.513 -0.9788 4671600.0 -256000.0 -0.28 4752080.0 -229000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L05 mock treatment 3910120.0 -463711.45833333 -0.512730557303312 -0.1697 -0.2922 4882040.0 -45400.0 -0.05 5248360.0 267000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L06 mock treatment 3986760.0 -387071.45833333 -0.427988916342008 -0.3639 -0.7636 4736000.0 -191000.0 -0.21 4988080.0 7220.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L07 mock treatment 3663400.0 -710431.45833333 -0.78553141400964 -0.6299 -0.7101 4561200.0 -366000.0 -0.4 5076000.0 95100.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L08 mock treatment 3667360.0 -706471.45833333 -0.781152801037213 -0.1844 -0.2045 4938320.0 10900.0 0.01 5429120.0 448000.0 0.45 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L09 mock treatment 3738240.0 -635591.45833333 -0.702780051672166 -0.7016 -0.7851 4962280.0 34900.0 0.04 4432120.0 -549000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L10 mock treatment 3756000.0 -617831.45833333 -0.683142635917041 -0.506 -0.6447 4605600.0 -322000.0 -0.35 5139360.0 158000.0 0.16 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L11 mock treatment 3851600.0 -522231.45833333 -0.577436726784725 -0.0635 -0.0922 5026920.0 99500.0 0.11 5338120.0 357000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L12 mock treatment 4163440.0 -210391.45833333 -0.232632012309607 -0.0256 -0.0785 5132920.0 206000.0 0.23 4944280.0 -36600.0 -0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L13 mock treatment 3969040.0 -404791.45833333 -0.44758210368327 -0.4606 -0.6917 5042800.0 115000.0 0.13 4505920.0 -475000.0 -0.48 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L14 mock treatment 4056960.0 -316871.45833333 -0.350368050012629 -0.1181 -0.3232 5002280.0 74900.0 0.08 5044400.0 63500.0 0.06 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L15 mock treatment 3873240.0 -500591.45833333 -0.5535091548849 -0.337 -0.6003 4972560.0 45200.0 0.05 4901440.0 -79400.0 -0.08 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L16 mock treatment 4148400.0 -225431.45833333 -0.249261895922055 -0.2498 -0.8868 4856680.0 -70700.0 -0.08 4875200.0 -106000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L17 mock treatment 4182800.0 -191031.45833333 -0.211225459999966 0.1264 0.3005 4995040.0 67600.0 0.07 5335640.0 355000.0 0.36 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L18 mock treatment 3929680.0 -444151.45833333 -0.491102862924357 -0.443 -0.8379 4809520.0 -118000.0 -0.13 4834320.0 -147000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L19 mock treatment 3216600.0 -1157231.45833333 -1.27956279685816 -1.219 -0.7338 3978760.0 -949000.0 -1.04 5187240.0 206000.0 0.21 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L20 mock treatment 3990360.0 -383471.45833333 -0.424008359094347 -0.1713 -0.3288 4798840.0 -129000.0 -0.14 5248000.0 267000.0 0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L21 mock treatment 3921000.0 -452831.45833333 -0.500700428732605 -0.1871 -0.333 4864520.0 -62900.0 -0.07 5225480.0 245000.0 0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L22 mock treatment 3991240.0 -382591.45833333 -0.423035333989364 -1.0571 -0.9736 4223760.0 -704000.0 -0.77 4345760.0 -635000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L23 mock treatment 4174360.0 -199471.45833333 -0.220557655325037 -0.5865 -0.9622 4511600.0 -416000.0 -0.46 4642080.0 -339000.0 -0.34 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base L24 mock treatment 3627000.0 -746831.45833333 -0.825779270624873 -1.0573 -0.9686 4427000.0 -500000.0 -0.55 4524960.0 -456000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M01 mock treatment 3916960.0 -456871.45833333 -0.505167498532757 -1.1191 -0.9588 4455800.0 -472000.0 -0.52 4067360.0 -914000.0 -0.92 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M02 mock treatment 4334200.0 -39631.4583333302 -0.0438209135289138 -0.6318 -0.8386 4523960.0 -403000.0 -0.44 4374360.0 -607000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M03 mock treatment 3962560.0 -411271.45833333 -0.454747106729058 -0.8791 -0.9968 4458440.0 -469000.0 -0.51 4428480.0 -552000.0 -0.55 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M04 mock treatment 4021960.0 -351871.45833333 -0.389067912142661 -0.2136 -0.4461 5116040.0 189000.0 0.21 4794120.0 -187000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M05 mock treatment 4100360.0 -273471.45833333 -0.30238022097139 -0.1443 -0.4734 4945840.0 18400.0 0.02 5013040.0 32200.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M06 mock treatment 3281560.0 -1092271.45833333 -1.20773585274482 -0.9958 -0.7886 4660560.0 -267000.0 -0.29 4756840.0 -224000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M07 mock treatment 3891600.0 -482231.45833333 -0.533208312921832 -0.1842 -0.2924 5218400.0 291000.0 0.32 4876720.0 -104000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M08 mock treatment 4095560.0 -278271.45833333 -0.307687630634937 -0.3306 -0.9171 4797800.0 -130000.0 -0.14 4858280.0 -123000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M09 mock treatment 3711480.0 -662351.45833333 -0.732368860546442 -0.7554 -0.8745 4528960.0 -398000.0 -0.44 4841600.0 -139000.0 -0.14 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M10 mock treatment 4392440.0 18608.5416666698 0.0205756570554593 -0.1007 -0.5551 4763400.0 -164000.0 -0.18 4965520.0 -15300.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M11 mock treatment 4257480.0 -116351.45833333 -0.128651011317944 -0.204 -0.8428 4741160.0 -186000.0 -0.2 4960240.0 -20600.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M12 mock treatment 3936240.0 -437591.45833333 -0.483849403050842 -0.1745 -0.3446 4960600.0 33200.0 0.04 5125560.0 145000.0 0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M13 mock treatment 4256960.0 -116871.45833333 -0.129225980698161 0.2294 0.5746 5209080.0 282000.0 0.31 5198200.0 217000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M14 mock treatment 4024920.0 -348911.45833333 -0.385795009516807 -0.1968 -0.293 5302320.0 375000.0 0.41 4616560.0 -364000.0 -0.37 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M15 mock treatment 3803800.0 -570031.45833333 -0.630289681350883 -0.5574 -0.8197 4713400.0 -214000.0 -0.23 4880480.0 -100000.0 -0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M16 mock treatment 4207360.0 -166471.45833333 -0.18406921388815 0.1086 0.2743 4947760.0 20400.0 0.02 5329480.0 349000.0 0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M17 mock treatment 3988160.0 -385671.45833333 -0.426440921856807 -0.3504 -0.7011 4698200.0 -229000.0 -0.25 5051120.0 70300.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M18 mock treatment 3957040.0 -416791.45833333 -0.460850627842138 -0.6538 -0.8206 4334240.0 -593000.0 -0.65 4958960.0 -21900.0 -0.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M19 mock treatment 3975160.0 -398671.45833333 -0.440815156362247 -0.9735 -0.9874 4390000.0 -537000.0 -0.59 4326440.0 -654000.0 -0.66 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M20 mock treatment 3657560.0 -716271.45833333 -0.791988762433622 -0.8287 -0.8669 4451360.0 -476000.0 -0.52 4859200.0 -122000.0 -0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M21 mock treatment 3717600.0 -656231.45833333 -0.725601913225419 -1.2602 -0.8894 3844000.0 -1080000.0 -1.19 4711200.0 -270000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M22 mock treatment 3890160.0 -483671.45833333 -0.534800535820896 -0.8425 -0.9719 4631320.0 -296000.0 -0.32 4382800.0 -598000.0 -0.6 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M23 mock treatment 3800880.0 -572951.45833333 -0.633518355562875 -0.8752 -0.977 4594920.0 -332000.0 -0.36 4464440.0 -516000.0 -0.52 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base M24 mock treatment 3583240.0 -790591.45833333 -0.874165155390879 -1.5669 -0.9954 3993520.0 -934000.0 -1.02 4166640.0 -814000.0 -0.82 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N01 mock treatment 4338800.0 -35031.4583333302 -0.0387346459346811 -0.3654 -0.813 4756080.0 -171000.0 -0.19 4575760.0 -405000.0 -0.41 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N02 mock treatment 3743640.0 -630191.45833333 -0.696809215800675 -0.6859 -0.8651 4799880.0 -128000.0 -0.14 4630560.0 -350000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N03 mock treatment 4572120.0 198288.54166667 0.219249692127577 0.0364 0.0843 5085440.0 158000.0 0.17 4652760.0 -328000.0 -0.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N04 mock treatment 4013480.0 -360351.45833333 -0.398444335881595 0.6965 0.4928 5180960.0 254000.0 0.28 6303240.0 1320000.0 1.33 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N05 mock treatment 3786280.0 -587551.45833333 -0.649661726622831 -0.7203 -0.9087 4547480.0 -380000.0 -0.42 4799680.0 -181000.0 -0.18 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N06 mock treatment 4313400.0 -60431.4583333302 -0.0668196887376185 1.2773 0.7743 5744560.0 817000.0 0.89 6360280.0 1380000.0 1.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N07 mock treatment 3757440.0 -616391.45833333 -0.681550413017977 -0.3184 -0.4605 4940920.0 13500.0 0.01 5095720.0 115000.0 0.12 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N08 mock treatment 3920960.0 -452871.45833333 -0.500744657146468 -0.3722 -0.677 4730640.0 -197000.0 -0.22 5052160.0 71300.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N09 mock treatment 3873400.0 -500431.45833333 -0.553332241229448 -0.4226 -0.537 5197840.0 270000.0 0.3 4507680.0 -473000.0 -0.47 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N10 mock treatment 3722600.0 -651231.45833333 -0.720073361492557 -0.4224 -0.528 5147080.0 220000.0 0.24 4729600.0 -251000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N11 mock treatment 4032120.0 -341711.45833333 -0.377833895021486 -0.0197 -0.0438 5081560.0 154000.0 0.17 5155200.0 174000.0 0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N12 mock treatment 4906840.0 533008.54166667 0.589353059332271 0.2595 0.2966 4450880.0 -477000.0 -0.52 5361440.0 381000.0 0.38 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N13 mock treatment 3844880.0 -528951.45833333 -0.584867100313691 -0.2345 -0.3124 5301680.0 374000.0 0.41 4750440.0 -230000.0 -0.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N14 mock treatment 3819120.0 -554711.45833333 -0.613350198841395 -0.5396 -0.695 5050840.0 123000.0 0.14 4526040.0 -455000.0 -0.46 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N15 mock treatment 3789960.0 -583871.45833333 -0.645592712547444 -0.5085 -0.6945 4624400.0 -303000.0 -0.33 5077120.0 96300.0 0.1 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N16 mock treatment 3863960.0 -509871.45833333 -0.563770146901091 -0.6117 -0.9006 4608240.0 -319000.0 -0.35 4835120.0 -146000.0 -0.15 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N17 mock treatment 3925800.0 -448031.45833333 -0.495393019069058 -0.3379 -0.5376 4640040.0 -287000.0 -0.31 5204920.0 224000.0 0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N18 mock treatment 3983920.0 -389911.45833333 -0.431129133726273 -0.6746 -0.9824 4514760.0 -413000.0 -0.45 4696480.0 -284000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N19 mock treatment 3809280.0 -564551.45833333 -0.624230388651667 -0.4232 -0.5588 5150160.0 223000.0 0.24 4629440.0 -351000.0 -0.35 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N20 mock treatment 3712200.0 -661631.45833333 -0.73157274909691 -0.7043 -0.8633 4636240.0 -291000.0 -0.32 4811960.0 -169000.0 -0.17 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N21 mock treatment 3686840.0 -686991.45833333 -0.759613563485984 -0.7836 -0.8056 4372720.0 -555000.0 -0.61 4990640.0 9780.0 0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N22 mock treatment 3779640.0 -594191.45833333 -0.657003643324071 -1.3401 -0.9748 3992600.0 -935000.0 -1.02 4342760.0 -638000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N23 mock treatment 3312560.0 -1061271.45833333 -1.17345883200108 -0.8922 -0.7012 4489200.0 -438000.0 -0.48 5088560.0 108000.0 0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base N24 mock treatment 3489680.0 -884151.45833333 -0.977615415416187 -1.4717 -0.9857 4082640.0 -845000.0 -0.93 4336760.0 -644000.0 -0.65 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O01 mock treatment 3689880.0 -683951.45833333 -0.756252204032404 -1.4615 -0.9881 3987560.0 -940000.0 -1.03 4237560.0 -743000.0 -0.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O02 mock treatment 4067960.0 -305871.45833333 -0.338205236200334 -0.7981 -0.981 4419080.0 -508000.0 -0.56 4495200.0 -486000.0 -0.49 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O03 mock treatment 4232120.0 -141711.45833333 -0.156691825707018 -0.4602 -0.9581 4613760.0 -314000.0 -0.34 4685000.0 -296000.0 -0.3 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O04 mock treatment 4030040.0 -343791.45833333 -0.380133772542357 -0.6274 -0.8593 4845560.0 -81800.0 -0.09 4366120.0 -615000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O05 mock treatment 4648600.0 274768.54166667 0.30381441943343 -0.2885 -0.4304 4441160.0 -486000.0 -0.53 4710880.0 -270000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O06 mock treatment 4062320.0 -311511.45833333 -0.344441442555002 -0.5409 -0.99 4614160.0 -313000.0 -0.34 4732360.0 -249000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O07 mock treatment 3834480.0 -539351.45833333 -0.596366487918044 -0.966 -0.9403 4212000.0 -715000.0 -0.78 4688560.0 -292000.0 -0.29 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O08 mock treatment 4276320.0 -97511.4583333302 -0.107819428388521 -0.8171 -0.8778 4322320.0 -605000.0 -0.66 4338280.0 -643000.0 -0.64 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O09 mock treatment 4042760.0 -331071.45833333 -0.366069136933957 -0.3123 -0.7756 4774280.0 -153000.0 -0.17 4973640.0 -7220.0 -0.01 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O10 mock treatment 4556080.0 182248.54166667 0.201514098168557 0.1405 0.657 4904360.0 -23000.0 -0.03 5047760.0 66900.0 0.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O11 mock treatment 4173080.0 -200751.45833333 -0.221972964568649 -0.1254 -0.3221 5136040.0 209000.0 0.23 4758000.0 -223000.0 -0.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O12 mock treatment 3983680.0 -390151.45833333 -0.431394504209451 -0.7562 -0.9406 4350120.0 -577000.0 -0.63 4735560.0 -245000.0 -0.25 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O13 mock treatment 4235000.0 -138831.45833333 -0.15350737990889 -1.018 -0.8682 4344880.0 -583000.0 -0.64 4012560.0 -968000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O14 mock treatment 4380480.0 6648.54166666977 0.00735136131045408 -0.0755 -0.4515 4776880.0 -151000.0 -0.16 5007520.0 26700.0 0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O15 mock treatment 4018640.0 -355191.45833333 -0.392738870493282 -0.2762 -0.6658 4811320.0 -116000.0 -0.13 5022160.0 41300.0 0.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O16 mock treatment 4399800.0 25968.5416666698 0.0287136852062317 -0.2495 -0.5742 4532360.0 -395000.0 -0.43 4952760.0 -28100.0 -0.03 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O17 mock treatment 4113280.0 -260551.45833333 -0.288094443293675 -0.6236 -0.8302 4301480.0 -626000.0 -0.69 4874760.0 -106000.0 -0.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O18 mock treatment 4125200.0 -248631.45833333 -0.274914375962533 -0.4529 -0.9789 4634640.0 -293000.0 -0.32 4792560.0 -188000.0 -0.19 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O19 mock treatment 3958000.0 -415831.45833333 -0.459789145909428 -0.6668 -0.9775 4538320.0 -389000.0 -0.43 4712800.0 -268000.0 -0.27 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O20 mock treatment 4550640.0 176808.54166667 0.195499033883204 -0.3386 -0.5745 4608560.0 -319000.0 -0.35 4549520.0 -431000.0 -0.43 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O21 mock treatment 4025480.0 -348351.45833333 -0.385175811722727 -0.696 -0.8073 4881080.0 -46300.0 -0.05 4213960.0 -767000.0 -0.77 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O22 mock treatment 3763040.0 -610791.45833333 -0.675358435077172 -1.053 -0.9917 4333080.0 -594000.0 -0.65 4484960.0 -496000.0 -0.5 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O23 mock treatment 3740800.0 -633031.45833333 -0.699949433184941 -1.0683 -0.994 4439920.0 -487000.0 -0.53 4366520.0 -614000.0 -0.62 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base O24 mock treatment 3693880.0 -679951.45833333 -0.751829362646115 -1.6221 -0.9771 4162920.0 -764000.0 -0.84 3764680.0 -1220000.0 -1.22 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P01 mock treatment 3217720.0 -1156111.45833333 -1.27832440127 -2.3947 -0.9945 3476360.0 -1450000.0 -1.59 3705080.0 -1280000.0 -1.28 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P02 mock treatment 3438480.0 -935351.45833333 -1.03422778516069 -1.6039 -0.9938 4053320.0 -874000.0 -0.96 4197160.0 -784000.0 -0.79 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P03 mock treatment 3395080.0 -978751.45833333 -1.08221561420193 -1.4796 -0.9677 4423280.0 -504000.0 -0.55 4055680.0 -925000.0 -0.93 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P04 mock treatment 3635520.0 -738311.45833333 -0.816358618472077 -1.4184 -0.9968 4104760.0 -823000.0 -0.9 4244040.0 -737000.0 -0.74 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P05 mock treatment 3814400.0 -559431.45833333 -0.618569151677216 -1.3885 -0.9796 4225000.0 -702000.0 -0.77 3967360.0 -1010000.0 -1.02 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P06 mock treatment 3927400.0 -446431.45833333 -0.493623882514542 -0.5129 -0.5931 4325560.0 -602000.0 -0.66 5244240.0 263000.0 0.26 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P07 mock treatment 4107600.0 -266231.45833333 -0.294374878062206 -0.7995 -0.9622 4491840.0 -436000.0 -0.48 4369640.0 -611000.0 -0.61 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P08 mock treatment 3674720.0 -699111.45833333 -0.773014772886441 -1.0207 -0.9442 4651320.0 -276000.0 -0.3 4290760.0 -690000.0 -0.69 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P09 mock treatment 3594120.0 -779711.45833333 -0.862135026820172 -1.5291 -0.9958 4201200.0 -726000.0 -0.8 3993360.0 -988000.0 -0.99 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P10 mock treatment 4397720.0 23888.5416666698 0.0264138076853612 -0.915 -0.8027 4209840.0 -718000.0 -0.79 4158320.0 -823000.0 -0.83 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P11 mock treatment 3944080.0 -429751.45833333 -0.475180633933715 -1.0867 -0.9624 4442160.0 -485000.0 -0.53 4108280.0 -873000.0 -0.88 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P12 mock treatment 3682960.0 -690871.45833333 -0.763903719630685 -1.7873 -0.9722 3682960.0 -1240000.0 -1.36 4015280.0 -966000.0 -0.97 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P13 mock treatment 3810840.0 -562991.45833333 -0.622505480511014 -1.1096 -0.9964 4275080.0 -652000.0 -0.71 4397880.0 -583000.0 -0.59 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P14 mock treatment 3847200.0 -526631.45833333 -0.582301852309644 -1.4661 -0.9726 4120760.0 -807000.0 -0.88 3910960.0 -1070000.0 -1.07 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P15 mock treatment 4677880.0 304048.54166667 0.336189618381068 -0.5074 -0.527 4550360.0 -377000.0 -0.41 4181520.0 -799000.0 -0.8 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P16 mock treatment 3541200.0 -832631.45833333 -0.92064921836078 -1.613 -0.991 4212760.0 -715000.0 -0.78 3894160.0 -1090000.0 -1.09 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P17 mock treatment 3428600.0 -945231.45833333 -1.04515220338483 -1.6066 -0.9955 4166160.0 -761000.0 -0.83 4080200.0 -901000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P18 mock treatment 3755760.0 -618071.45833333 -0.683408006400218 -1.4257 -0.9929 4114880.0 -813000.0 -0.89 4087840.0 -893000.0 -0.9 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P19 mock treatment 3566080.0 -807751.45833333 -0.89313914493806 -1.8147 -0.9923 3819480.0 -1110000.0 -1.21 3947800.0 -1030000.0 -1.04 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P20 mock treatment 3819040.0 -554791.45833333 -0.613438655669121 -1.5322 -0.9739 4079880.0 -848000.0 -0.93 3872480.0 -1110000.0 -1.11 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P21 mock treatment 3630520.0 -743311.45833333 -0.821887170204938 -1.393 -0.9993 4170880.0 -757000.0 -0.83 4221120.0 -760000.0 -0.76 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P22 mock treatment 4189560.0 -184271.45833333 -0.203750858057137 -1.2641 -0.8675 4235000.0 -692000.0 -0.76 3757720.0 -1220000.0 -1.23 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P23 mock treatment 3425560.0 -948271.45833333 -1.04851356283841 -2.2388 -0.9695 3946000.0 -981000.0 -1.07 3232720.0 -1750000.0 -1.75 1054.0009 CellTiterGlo(1054.0009) KRasSyntheticLethal 1054.0009.Base P24 mock treatment 3275360.0 -1098471.45833333 -1.21459125689357 -2.4318 -0.9491 3059640.0 -1870000.0 -2.05 4032200.0 -949000.0 -0.95