ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B RAW_VALUE_C BSUB_VALUE_C Z_SCORE_C COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A01 compound treatment 6786600.0 -2920000.0 -2.51 6457680.0 -3140000.0 -2.61 7050720.0 -2099385.0 -1.76533012905538 -3.9761 -0.9868 3000745 BCB02_000001 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5cccc(O)c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A02 compound treatment 7262880.0 -2440000.0 -2.1 7175320.0 -2430000.0 -2.01 7300120.0 -1849985.0 -1.55561474374663 -3.2747 -0.9921 3000746 BCB02_000002 CC(C)OC(=O)C1=CCC(O1)c2cccc(Cl)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A03 compound treatment 8277000.0 -1430000.0 -1.23 8179800.0 -1420000.0 -1.18 8365840.0 -784265.0 -0.659472480590086 -1.7723 -0.9696 3000747 BCB02_000003 OC(C1CCCCC1)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A04 compound treatment 8488680.0 -1220000.0 -1.05 8656120.0 -945000.0 -0.78 8095400.0 -1054705.0 -0.886879973785349 -1.5703 -0.9928 3000748 BCB02_000004 CCOC(=O)C1=CCC(O1)c2cccc(Cl)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A05 compound treatment 9202520.0 -505000.0 -0.43 8042480.0 -1560000.0 -1.29 8601560.0 -548545.0 -0.461260328926178 -1.2637 -0.8776 3000749 BCB02_000005 CC(=C)[C@H]1CCC(=CC1)C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A06 compound treatment 8721840.0 -986000.0 -0.85 8679800.0 -921000.0 -0.76 8299000.0 -851105.0 -0.715676876556553 -1.3442 -0.9975 3000750 BCB02_000006 COC(=O)C1=CCC(O1)c2cccc(Cl)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A07 compound treatment 8763480.0 -944000.0 -0.81 9140680.0 -460000.0 -0.38 8817560.0 -332545.0 -0.279630324007612 -0.851 -0.9051 3093754 BCB02_000007 CCCCC(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A08 compound treatment 9249200.0 -458000.0 -0.39 8695000.0 -906000.0 -0.75 8481440.0 -668665.0 -0.562266792772558 -0.9863 -0.9687 2065163 BCB02_000008 CCOC(=O)/C=C/c1ccccc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A09 compound treatment 9973320.0 266000.0 0.23 9234960.0 -366000.0 -0.3 8588000.0 -562105.0 -0.472662657012732 -0.3162 -0.5212 3093755 BCB02_000009 CCCCCCCCCCC(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A10 compound treatment 9871360.0 164000.0 0.14 9455040.0 -146000.0 -0.12 8751680.0 -398425.0 -0.335027475507775 -0.182 -0.4749 3000752 BCB02_000010 CCOC(=O)/C=C/c1cc(F)ccc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A11 compound treatment 9441640.0 -266000.0 -0.23 8769640.0 -831000.0 -0.69 8505760.0 -644345.0 -0.541816599626171 -0.8432 -0.9302 3093756 BCB02_000011 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A12 compound treatment 8305160.0 -1400000.0 -1.21 8067320.0 -1530000.0 -1.27 7853000.0 -1297105.0 -1.09070920152729 -2.0612 -0.998 3000753 BCB02_000012 CCOC(=O)/C=C/c1cc(ccc1O)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A13 compound treatment 9005600.0 -702000.0 -0.6 8411320.0 -1190000.0 -0.99 8559160.0 -590945.0 -0.49691362618797 -1.2055 -0.9572 3093757 BCB02_000013 COc1ccc(C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O)c6ccccc16 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A14 compound treatment 8932520.0 -775000.0 -0.67 8855560.0 -746000.0 -0.62 8412800.0 -737305.0 -0.619984772113346 -1.1001 -0.9994 3000754 BCB02_000014 CCOC(=O)/C=C/c1cccc(OC)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A15 compound treatment 8900360.0 -807000.0 -0.69 9105080.0 -496000.0 -0.41 8990840.0 -159265.0 -0.133922697839608 -0.716 -0.8748 3093824 BCB02_000015 COc1cc(OC)c(cc1Br)C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A16 compound treatment 9108440.0 -599000.0 -0.52 9064880.0 -536000.0 -0.44 8724040.0 -426065.0 -0.358269389100132 -0.7613 -0.9895 3000755 BCB02_000016 CCOC(=O)/C=C/c1cccc(C)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A17 mock treatment 9480120.0 -227000.0 -0.2 8803520.0 -798000.0 -0.66 9130080.0 -20025.0 -0.0168386150393253 -0.5047 -0.7313 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A18 mock treatment 8961080.0 -746000.0 -0.64 8807520.0 -794000.0 -0.66 8595880.0 -554225.0 -0.466036525351814 -1.0201 -0.9892 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A19 mock treatment 8870120.0 -837000.0 -0.72 9103680.0 -497000.0 -0.41 8870040.0 -280065.0 -0.23550095984962 -0.7903 -0.9155 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A20 mock treatment 9501040.0 -206000.0 -0.18 8559600.0 -1040000.0 -0.86 8907720.0 -242385.0 -0.203816614547159 -0.7191 -0.7943 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A21 mock treatment 8509680.0 -1200000.0 -1.03 8309720.0 -1290000.0 -1.07 8166240.0 -983865.0 -0.827312059209279 -1.6914 -0.9941 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A22 mock treatment 8317160.0 -1390000.0 -1.2 8158240.0 -1440000.0 -1.2 8181160.0 -968945.0 -0.814766134795459 -1.8523 -0.9861 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A23 mock treatment 8604480.0 -1100000.0 -0.95 7960680.0 -1640000.0 -1.36 7852320.0 -1297785.0 -1.09128099969093 -1.9638 -0.9889 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 A24 mock treatment 9873840.0 166000.0 0.14 8209400.0 -1390000.0 -1.15 7268320.0 -1881785.0 -1.58235471669297 -1.4975 -0.7625 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B01 compound treatment 9023400.0 -684000.0 -0.59 8873200.0 -728000.0 -0.6 8399400.0 -750705.0 -0.631252559455516 -1.053 -0.9996 3093825 BCB02_000017 COc1ccc(cc1OCc2ccccc2)C(O)C3C=CC4C(N3n5cnnc5)C(=O)N(Cc6ccccc6)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B02 compound treatment 9154320.0 -553000.0 -0.48 9674880.0 73800.0 0.06 8590040.0 -560065.0 -0.470947262521835 -0.5114 -0.7606 3000756 BCB02_000018 CCOC(=O)C1=CCC(N(CCN2CC(=CCC2c3cc4ccccc4[nH]3)C(=O)OCC)C1)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B03 compound treatment 9119560.0 -588000.0 -0.51 9579960.0 -21100.0 -0.02 9206400.0 56295.0 0.0473373200319011 -0.2749 -0.5407 3093826 BCB02_000019 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5cc(cc(c5)C(F)(F)F)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B04 compound treatment 9751920.0 44400.0 0.04 8878840.0 -722000.0 -0.6 8663080.0 -487025.0 -0.409529412710483 -0.5603 -0.771 3000757 BCB02_000020 CC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B05 compound treatment 1.000704E7 300000.0 0.26 9651000.0 49900.0 0.04 9176840.0 26735.0 0.0224809175069345 0.1857 0.7087 3093827 BCB02_000021 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(s5)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B06 compound treatment 9880360.0 173000.0 0.15 9747560.0 146000.0 0.12 9055400.0 -94705.0 -0.0796355074806145 0.1101 0.5293 3093828 BCB02_000022 Cc1ccc(cc1)[C@@H]2C[C@@H](Sc3ccccc3)[C@@H](CN2S(=O)(=O)c4ccc(C)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B07 compound treatment 9938320.0 231000.0 0.2 1.017216E7 571000.0 0.47 9277960.0 127855.0 0.1075106679577 0.4503 0.8579 3000758 BCB02_000023 CC(C(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B08 compound treatment 1.043152E7 724000.0 0.62 1.026752E7 666000.0 0.55 9360240.0 210135.0 0.176698245757235 0.7809 0.9171 3093829 BCB02_000024 Cc1ccc(cc1)C2CC=C(CN2S(=O)(=O)c3ccc(C)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B09 compound treatment 1.079256E7 1090000.0 0.93 1.04654E7 864000.0 0.72 1.02258E7 1075695.0 0.904530037689241 1.4753 0.9937 3000759 BCB02_000025 CC(CC(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(C)o5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B10 compound treatment 1.0048E7 340000.0 0.29 1.001772E7 417000.0 0.35 9623640.0 473535.0 0.398185946199596 0.5986 0.9924 3093830 BCB02_000026 Cc1ccc(cc1)S(=O)(=O)N2CC(=CCC2c3ccccc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B11 compound treatment 1.029496E7 587000.0 0.51 9485680.0 -115000.0 -0.1 9133760.0 -16345.0 -0.0137441779184905 0.2287 0.4442 3093831 BCB02_000027 OC(Cc1ccccc1)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B12 compound treatment 1.049952E7 792000.0 0.68 9925200.0 324000.0 0.27 9631760.0 481655.0 0.405013888977091 0.7826 0.9348 3000760 BCB02_000028 Cc1ccc(cc1)[C@@H]2CC=C([C@@H](N2S(=O)(=O)c3ccc(C)cc3)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B13 compound treatment 1.035392E7 646000.0 0.56 9265800.0 -335000.0 -0.28 9344680.0 194575.0 0.163614158365879 0.2551 0.3966 3093832 BCB02_000029 OC(C1CCCCC1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B14 compound treatment 1.05726E7 865000.0 0.74 9648160.0 47100.0 0.04 9678560.0 528455.0 0.444367056709446 0.7089 0.8168 3093833 BCB02_000030 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B15 compound treatment 1.046E7 752000.0 0.65 9666600.0 65500.0 0.05 9147040.0 -3065.0 -0.00257729613460835 0.4038 0.6213 3000761 BCB02_000031 CC(=C)[C@H]1CCC(=CC1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B16 compound treatment 1.007396E7 366000.0 0.32 9550560.0 -50500.0 -0.04 9355480.0 205375.0 0.172695658611807 0.2576 0.7115 3093834 BCB02_000032 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccc(C#N)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B17 mock treatment 9869360.0 162000.0 0.14 9990400.0 389000.0 0.32 9685240.0 535135.0 0.449984132787483 0.5267 0.9222 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B18 mock treatment 1.000736E7 300000.0 0.26 9748920.0 148000.0 0.12 9512000.0 361895.0 0.304310141805575 0.3955 0.9474 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B19 mock treatment 9504840.0 -203000.0 -0.17 1.01206E7 519000.0 0.43 9513560.0 363455.0 0.30562191406332 0.3246 0.5833 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B20 mock treatment 1.040732E7 700000.0 0.6 1.004316E7 442000.0 0.37 9452880.0 302775.0 0.254597336755642 0.7064 0.9423 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B21 mock treatment 8867520.0 -840000.0 -0.72 9271120.0 -330000.0 -0.27 9298520.0 148415.0 0.12479915361106 -0.5034 -0.6429 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B22 mock treatment 9197320.0 -510000.0 -0.44 9344800.0 -256000.0 -0.21 9442520.0 292415.0 0.24588582355677 -0.2343 -0.4289 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B23 mock treatment 9401080.0 -306000.0 -0.26 9486320.0 -115000.0 -0.1 8971720.0 -178385.0 -0.150000316793511 -0.2938 -0.9241 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 B24 mock treatment 8714080.0 -993000.0 -0.85 8311080.0 -1290000.0 -1.07 8086400.0 -1063705.0 -0.894447890656956 -1.6279 -0.9951 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C01 compound treatment 8274400.0 -1430000.0 -1.23 8879320.0 -722000.0 -0.6 8275160.0 -874945.0 -0.735723447469787 -1.4826 -0.9528 3093835 BCB02_000033 CC(=O)n1cc(C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5)c6ccccc16 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C02 compound treatment 9420600.0 -287000.0 -0.25 9402800.0 -198000.0 -0.16 9121840.0 -28265.0 -0.0237674633751076 -0.2513 -0.8441 3000762 BCB02_000034 CCOC(=O)/C=C/c1ccccc1OC(=O)C#CC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C03 compound treatment 9681800.0 -25700.0 -0.02 9735720.0 135000.0 0.11 9284800.0 134695.0 0.113262284780121 0.1171 0.7291 3000763 BCB02_000035 Cc1ccccc1C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C04 compound treatment 1.063376E7 926000.0 0.8 9237040.0 -364000.0 -0.3 9319240.0 169135.0 0.142222180008803 0.368 0.4258 3093836 BCB02_000036 CCOC(=O)[C@H]1CC=C2[C@@H]1c3ccccc3OC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C05 compound treatment 1.000308E7 296000.0 0.25 1.026948E7 668000.0 0.55 8884960.0 -265145.0 -0.222955035435801 0.3383 0.5208 3093837 BCB02_000037 OC(/C=C/c1ccc(cc1)[N+](=O)[O-])C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C06 compound treatment 9933840.0 226000.0 0.19 1.003876E7 438000.0 0.36 9000720.0 -149385.0 -0.125614806873888 0.2495 0.5794 3000764 BCB02_000038 CCOC(=O)[C@H]1CC=C2[C@@H]1c3cc(Br)ccc3OC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C07 compound treatment 1.053492E7 827000.0 0.71 1.041348E7 812000.0 0.67 9539320.0 389215.0 0.327282973909164 0.9892 0.957 3093838 BCB02_000039 OC(C(c1ccccc1)c2ccccc2)C3C=CC4C(N3n5cnnc5)C(=O)N(Cc6ccccc6)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C08 compound treatment 9380600.0 -327000.0 -0.28 6214000.0 -3390000.0 -2.81 4058800.0 -5091305.0 -4.28117477866628 -4.2564 -0.8299 3000765 BCB02_000040 CCOC(=O)/C=C/c1cc(Br)ccc1OC(=O)C#CC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C09 compound treatment 1.01328E7 425000.0 0.37 9615120.0 14000.0 0.01 9035520.0 -114585.0 -0.0963521949703417 0.1624 0.4289 3093839 BCB02_000041 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5cccc6ccccc56 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C10 compound treatment 1.032764E7 620000.0 0.53 8976840.0 -624000.0 -0.52 8838200.0 -311905.0 -0.262274567982061 -0.1423 -0.1804 3000766 BCB02_000042 O=c1oc2ccccc2cc1C#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C11 compound treatment 1.068636E7 979000.0 0.84 1.026956E7 668000.0 0.55 1.012808E7 977975.0 0.822359278056638 1.2813 0.9846 3093840 BCB02_000043 OC(C1CCC=CC1)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C12 compound treatment 1.012132E7 414000.0 0.36 1.0428E7 827000.0 0.69 1.01012E7 951095.0 0.799756433000106 1.0634 0.9561 3000767 BCB02_000044 Cn1c2C3NC(C(=O)c2c4ccccc14)C(C)(C=C3)C(=O)OCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C13 compound treatment 1.042648E7 719000.0 0.62 1.017792E7 577000.0 0.48 9582680.0 432575.0 0.363743515637261 0.8435 0.9778 3093841 BCB02_000045 CC(=O)n1cc(C(O)C2C=CC3C(N2n4cnnc4)C(=O)N(Cc5ccccc5)C3=O)c6ccccc16 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C14 compound treatment 9326280.0 -381000.0 -0.33 9463280.0 -138000.0 -0.11 8936880.0 -213225.0 -0.179296563883153 -0.359 -0.9181 3000768 BCB02_000046 [O-][N+](=O)c1ccccc1S(=O)(=O)N2C3CC=C(C2C(=O)c4c3[nH]c5ccccc45)C(=O)OCc6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C15 compound treatment 9904120.0 197000.0 0.17 9556240.0 -44900.0 -0.04 9705880.0 555775.0 0.467339888813035 0.346 0.6942 3093842 BCB02_000047 CCCCC(CC)C(O)C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C16 compound treatment 9926720.0 219000.0 0.19 1.014116E7 540000.0 0.45 9813240.0 663135.0 0.557616728294781 0.6895 0.9321 3093843 BCB02_000048 CCOC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C17 mock treatment 1.033548E7 628000.0 0.54 1.002648E7 425000.0 0.35 9825920.0 675815.0 0.568279082287223 0.8439 0.9813 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C18 mock treatment 1.056304E7 856000.0 0.74 1.085364E7 1250000.0 1.04 9209080.0 58975.0 0.0495908775003351 1.0536 0.8267 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C19 mock treatment 1.00894E7 382000.0 0.33 1.038808E7 787000.0 0.65 9324880.0 174775.0 0.146964741248344 0.6515 0.8739 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C20 mock treatment 9959320.0 252000.0 0.22 9893080.0 292000.0 0.24 9637120.0 487015.0 0.409521003913959 0.5014 0.959 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C21 mock treatment 9640200.0 -67300.0 -0.06 8960600.0 -641000.0 -0.53 9356120.0 206015.0 0.173233821589344 -0.2402 -0.4275 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C22 mock treatment 9673240.0 -34300.0 -0.03 1.00118E7 411000.0 0.34 9376760.0 226655.0 0.190589577614895 0.2897 0.74 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C23 mock treatment 9451600.0 -256000.0 -0.22 9504440.0 -96700.0 -0.08 9608480.0 458375.0 0.385438210669201 0.0491 0.1088 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 C24 mock treatment 8730360.0 -977000.0 -0.84 9038680.0 -562000.0 -0.47 8527200.0 -622905.0 -0.523788139878699 -1.0573 -0.9655 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D01 compound treatment 8982280.0 -725000.0 -0.62 8909320.0 -692000.0 -0.57 8634240.0 -515865.0 -0.433780381885721 -0.9421 -0.9892 3000769 BCB02_000049 CCCCC(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D02 compound treatment 9342040.0 -365000.0 -0.31 9823720.0 223000.0 0.18 9371200.0 221095.0 0.185914286747547 0.0324 0.079 3093844 BCB02_000050 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D03 compound treatment 8729600.0 -978000.0 -0.84 9956400.0 355000.0 0.29 9106880.0 -43225.0 -0.0363470229750231 -0.3367 -0.3773 3093845 BCB02_000051 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5c(F)cccc5Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D04 compound treatment 9897560.0 190000.0 0.16 1.00266E7 425000.0 0.35 9585960.0 435855.0 0.366501600897136 0.5098 0.9539 3000770 BCB02_000052 Cc1ccc(cc1)S(=O)(=O)N2C[C@H]([C@@H](C[C@H]2c3ccccc3)Sc4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D05 compound treatment 1.026984E7 562000.0 0.48 9548600.0 -52500.0 -0.04 9498760.0 348655.0 0.293176895207789 0.4235 0.7463 3093846 BCB02_000053 Cc1cc(C)c(C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5)c(C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D06 compound treatment 1.014456E7 437000.0 0.38 9001760.0 -599000.0 -0.5 8510040.0 -640065.0 -0.538217634713896 -0.3806 -0.4621 3000771 BCB02_000054 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D07 compound treatment 1.0272E7 564000.0 0.49 1.031616E7 715000.0 0.59 9412440.0 262335.0 0.220592163612555 0.7503 0.9404 3092586 BCB02_000055 Cc1ccccc1C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D08 compound treatment 9734800.0 27300.0 0.02 9195440.0 -406000.0 -0.34 8432040.0 -718065.0 -0.603806247601155 -0.5293 -0.7653 3092495 BCB02_000056 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(F)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D09 compound treatment 1.045824E7 751000.0 0.65 1.012424E7 523000.0 0.43 9661920.0 511815.0 0.430374819293498 0.8721 0.9805 3000772 BCB02_000057 OC(C1CCC=CC1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D10 compound treatment 1.014076E7 433000.0 0.37 1.024204E7 641000.0 0.53 9130360.0 -19745.0 -0.0166031687366531 0.5127 0.7892 3092496 BCB02_000058 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D11 compound treatment 1.01546E7 447000.0 0.38 1.061108E7 1010000.0 0.84 9221960.0 71855.0 0.060421407423257 0.7408 0.8017 3092497 BCB02_000059 CC(=O)n1cc(C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5)c6ccccc16 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D12 compound treatment 1.03924E7 685000.0 0.59 9212320.0 -389000.0 -0.32 8285480.0 -864625.0 -0.727045569457012 -0.2657 -0.2683 3000773 BCB02_000060 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc(Cl)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D13 compound treatment 1.00032E7 296000.0 0.25 1.009656E7 495000.0 0.41 9517040.0 366935.0 0.308548175253675 0.5624 0.9806 3092498 BCB02_000061 CCCCC(CC)C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D14 compound treatment 9896680.0 189000.0 0.16 8867920.0 -733000.0 -0.61 8686680.0 -463425.0 -0.389684652913825 -0.4822 -0.6511 3000774 BCB02_000062 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2Cl)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D15 compound treatment 9826600.0 119000.0 0.1 9822360.0 221000.0 0.18 9356720.0 206615.0 0.173738349380784 0.2654 0.9733 3092499 BCB02_000063 CC(=CCC/C(=C/C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)/C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D16 compound treatment 8565560.0 -1140000.0 -0.98 7750040.0 -1850000.0 -1.54 8001680.0 -1148425.0 -0.965687214808349 -2.0115 -0.975 3000775 BCB02_000064 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D17 mock treatment 1.084792E7 1140000.0 0.98 9814800.0 214000.0 0.18 9779280.0 629175.0 0.529060455299251 0.9745 0.8631 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D18 mock treatment 1.0951E7 1240000.0 1.07 1.005476E7 454000.0 0.38 1.011384E7 963735.0 0.810385151806451 1.303 0.9346 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D19 mock treatment 9933200.0 226000.0 0.19 9979360.0 378000.0 0.31 9502200.0 352095.0 0.296069521212047 0.4642 0.9812 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D20 mock treatment 1.016792E7 460000.0 0.4 9966520.0 365000.0 0.3 9639880.0 489775.0 0.411841831754585 0.6416 0.9917 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D21 mock treatment 9704000.0 -3510.0 0.0 9885360.0 284000.0 0.24 9823160.0 673055.0 0.565958254446597 0.4612 0.7521 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D22 mock treatment 9273040.0 -434000.0 -0.37 9302600.0 -299000.0 -0.25 8992200.0 -157905.0 -0.132779101512343 -0.4355 -0.9311 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D23 mock treatment 9639040.0 -68500.0 -0.06 9548520.0 -52600.0 -0.04 9484760.0 334655.0 0.281404580074178 0.1033 0.3551 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 D24 mock treatment 8948960.0 -759000.0 -0.65 9580480.0 -20600.0 -0.02 8660080.0 -490025.0 -0.412052051667685 -0.6247 -0.809 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E01 compound treatment 9278360.0 -429000.0 -0.37 9429520.0 -172000.0 -0.14 8311840.0 -838265.0 -0.704879981819727 -0.7024 -0.8688 3092500 BCB02_000065 CCCCC(CC)C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E02 compound treatment 1.01114E7 404000.0 0.35 1.017604E7 575000.0 0.48 8864560.0 -285545.0 -0.240108980344776 0.3374 0.5296 3000776 BCB02_000066 CCOC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(CC)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E03 compound treatment 9186200.0 -521000.0 -0.45 1.003108E7 430000.0 0.36 9532480.0 382375.0 0.321531357086743 0.1325 0.2017 3000847 BCB02_000067 CC1(C)[C@H]2C[C@@H]1C=C(C2)C(O)C3C=CC4C(N3n5cnnc5)C(=O)N(Cc6ccccc6)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E04 compound treatment 1.03112E7 604000.0 0.52 9749680.0 149000.0 0.12 9547280.0 397175.0 0.333976375942274 0.5639 0.8954 3000848 BCB02_000068 CCOC(=O)[C@H]1[C@H](C[C@@H]2[C@H]1C(=O)N(CC)C2=O)Sc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E05 compound treatment 9814080.0 107000.0 0.09 9570960.0 -30100.0 -0.03 9276520.0 126415.0 0.106299801258243 0.0999 0.7004 3000849 BCB02_000069 OC(C1C=CC2C(N1n3cnnc3)C(=O)N(Cc4ccccc4)C2=O)c5ccc(Br)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E06 compound treatment 1.040032E7 693000.0 0.6 9719160.0 118000.0 0.1 9465080.0 314975.0 0.264856068514931 0.5537 0.8393 3000850 BCB02_000070 OC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E07 compound treatment 1.015152E7 444000.0 0.38 9011920.0 -589000.0 -0.49 9035600.0 -114505.0 -0.0962849245981496 -0.1172 -0.1866 3000851 BCB02_000071 OC(/C=C/c1ccc(cc1)[N+](=O)[O-])C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E08 compound treatment 1.074164E7 1030000.0 0.89 1.096644E7 1370000.0 1.13 1.010764E7 957535.0 0.805171697961567 1.6326 0.9893 3092501 BCB02_000072 OC(=O)[C@H]1[C@H](C[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3)Sc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E09 compound treatment 1.055828E7 851000.0 0.73 1.134544E7 1740000.0 1.45 9660320.0 510215.0 0.429029411849656 1.5059 0.8977 3000852 BCB02_000073 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E10 compound treatment 9860480.0 153000.0 0.13 8930080.0 -671000.0 -0.56 7989480.0 -1160625.0 -0.975945946567638 -0.8088 -0.715 3092502 BCB02_000074 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E11 compound treatment 1.05788E7 871000.0 0.75 9829680.0 229000.0 0.19 9409440.0 259335.0 0.218069524655352 0.6683 0.8316 3092503 BCB02_000075 COc1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E12 compound treatment 9176040.0 -531000.0 -0.46 9022720.0 -578000.0 -0.48 9060800.0 -89305.0 -0.0750947573576503 -0.5845 -0.8761 3000853 BCB02_000076 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E13 compound treatment 1.075964E7 1050000.0 0.91 9904120.0 303000.0 0.25 9376120.0 226015.0 0.190051414637359 0.7776 0.8111 3092504 BCB02_000077 CN(C)c1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E14 compound treatment 1.075444E7 1050000.0 0.9 9546920.0 -54200.0 -0.04 9030480.0 -119625.0 -0.100590228418442 0.4362 0.4805 3000854 BCB02_000078 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(OC)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E15 compound treatment 1.04838E7 776000.0 0.67 1.019832E7 597000.0 0.5 9688560.0 538455.0 0.452775853233454 0.9332 0.9854 3092505 BCB02_000079 OC(C(c1ccccc1)c2ccccc2)C3C=CC4C(N3Nc5ccccc5F)C(=O)N(C4=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E16 compound treatment 9885240.0 178000.0 0.15 8988400.0 -613000.0 -0.51 8970440.0 -179665.0 -0.151076642748583 -0.2924 -0.5298 3000855 BCB02_000080 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E17 mock treatment 9819080.0 112000.0 0.1 9982200.0 381000.0 0.32 1.024688E7 1096775.0 0.922255780761849 0.7704 0.7864 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E18 mock treatment 9944880.0 237000.0 0.2 1.027892E7 678000.0 0.56 9543840.0 393735.0 0.331083749938015 0.6337 0.9268 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E19 mock treatment 1.036288E7 655000.0 0.56 1.063208E7 1030000.0 0.86 1.005512E7 905015.0 0.761008698617478 1.2588 0.9863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E20 mock treatment 9781800.0 74300.0 0.06 1.063144E7 1030000.0 0.85 9870840.0 720735.0 0.606051396273065 0.8803 0.8386 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E21 mock treatment 9793040.0 85500.0 0.07 1.013064E7 530000.0 0.44 9461640.0 311535.0 0.261963442510672 0.4474 0.8658 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E22 mock treatment 9254880.0 -453000.0 -0.39 9699800.0 98700.0 0.08 9594240.0 444135.0 0.373464084419014 0.038 0.0696 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E23 mock treatment 9835680.0 128000.0 0.11 9246040.0 -355000.0 -0.29 9304200.0 154095.0 0.129575350036696 -0.0316 -0.0928 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 E24 mock treatment 9074400.0 -633000.0 -0.54 8879040.0 -722000.0 -0.6 8543320.0 -606785.0 -0.510233159881998 -0.955 -0.9978 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F01 compound treatment 8390640.0 -1320000.0 -1.13 8403120.0 -1200000.0 -0.99 7641240.0 -1508865.0 -1.26877387671968 -1.9606 -0.9951 3092506 BCB02_000081 OC(COCc1ccccc1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F02 compound treatment 8610440.0 -1100000.0 -0.94 9160800.0 -440000.0 -0.37 7688680.0 -1461425.0 -1.22888254600979 -1.4655 -0.9204 3092507 BCB02_000082 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F03 compound treatment 9680080.0 -27400.0 -0.02 9518240.0 -82900.0 -0.07 9073160.0 -76945.0 -0.0647014848539769 -0.0907 -0.9318 3000856 BCB02_000083 COc1ccc(NN2C3C(C=CC2C(O)c4ccccc4)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F04 compound treatment 8908080.0 -799000.0 -0.69 8900560.0 -701000.0 -0.58 8066120.0 -1083985.0 -0.911500930007643 -1.259 -0.9825 3092508 BCB02_000084 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F05 compound treatment 9862000.0 154000.0 0.13 1.025592E7 655000.0 0.54 9215400.0 65295.0 0.054905236903508 0.4221 0.7511 3092509 BCB02_000085 CCCCC(O)C1C=CC2C(N1Nc3ccc(OC)cc3)C(=O)N(C4CCCCC4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F06 compound treatment 9378840.0 -329000.0 -0.28 8331160.0 -1270000.0 -1.05 6926280.0 -2223825.0 -1.86996919300013 -1.8512 -0.8551 3000857 BCB02_000086 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(F)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F07 compound treatment 9959520.0 252000.0 0.22 1.067404E7 1070000.0 0.89 8025680.0 -1124425.0 -0.94550610315073 0.0932 0.0708 3092510 BCB02_000087 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(F)cc4)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F08 compound treatment 9943320.0 236000.0 0.2 8672640.0 -928000.0 -0.77 7665760.0 -1484345.0 -1.24815550764281 -1.0481 -0.7079 3000858 BCB02_000088 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(Cl)c(Cl)c2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F09 compound treatment 1.05062E7 799000.0 0.69 1.022804E7 627000.0 0.52 9462800.0 312695.0 0.262938862907457 0.8489 0.942 3092511 BCB02_000089 C/C=C/C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F10 compound treatment 9181680.0 -526000.0 -0.45 7238600.0 -2360000.0 -1.96 6981000.0 -2169105.0 -1.82395625842076 -2.4459 -0.9008 3000859 BCB02_000090 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc(Cl)c2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F11 compound treatment 1.016088E7 453000.0 0.39 9510280.0 -90800.0 -0.08 9412600.0 262495.0 0.220726704356939 0.3092 0.6802 3092512 BCB02_000091 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F12 compound treatment 1.047844E7 771000.0 0.66 8581960.0 -1020000.0 -0.85 8203200.0 -946905.0 -0.796233147256547 -0.5648 -0.4222 3092513 BCB02_000092 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2Cl)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F13 compound treatment 1.048872E7 781000.0 0.67 9566000.0 -35100.0 -0.03 9401000.0 250895.0 0.21097250038909 0.4932 0.6993 3000860 BCB02_000093 CN(C)c1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F14 compound treatment 9722880.0 15400.0 0.01 8919600.0 -682000.0 -0.57 8010480.0 -1139625.0 -0.958287473867222 -0.872 -0.7837 3092514 BCB02_000094 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc3ccccc23)S(=O)(=O)c4ccc(C)cc4)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F15 compound treatment 1.060564E7 898000.0 0.77 9953840.0 353000.0 0.29 9736600.0 586495.0 0.493171711734787 0.8999 0.9351 3092515 BCB02_000095 COc1cc(cc(OC)c1OC)C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F16 compound treatment 9972760.0 265000.0 0.23 9018200.0 -583000.0 -0.48 8218480.0 -931625.0 -0.783384506167863 -0.5997 -0.6322 3000861 BCB02_000096 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccc(cc2)C(F)(F)F)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F17 mock treatment 1.055216E7 845000.0 0.73 1.058028E7 979000.0 0.81 9539040.0 388935.0 0.327047527606492 1.0775 0.9468 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F18 mock treatment 1.107544E7 1370000.0 1.18 1.027824E7 677000.0 0.56 9799880.0 649775.0 0.546382576138707 1.3195 0.933 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F19 mock treatment 1.02808E7 573000.0 0.49 1.016848E7 567000.0 0.47 9515320.0 365215.0 0.307101862251545 0.7339 0.9814 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F20 mock treatment 1.044936E7 742000.0 0.64 1.047664E7 876000.0 0.73 9252960.0 102855.0 0.0864886766476807 0.8379 0.863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F21 mock treatment 1.04778E7 770000.0 0.66 1.006756E7 466000.0 0.39 9194760.0 44655.0 0.0375494808779562 0.6278 0.8169 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F22 mock treatment 1.054492E7 837000.0 0.72 9865360.0 264000.0 0.22 9386840.0 236735.0 0.199065644511095 0.6576 0.844 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F23 mock treatment 9913120.0 206000.0 0.18 9934320.0 333000.0 0.28 9551720.0 401615.0 0.337709881598933 0.4567 0.9699 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 F24 mock treatment 8804720.0 -903000.0 -0.78 9079840.0 -521000.0 -0.43 8029400.0 -1120705.0 -0.9423780308438 -1.2423 -0.9588 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G01 compound treatment 8544640.0 -1160000.0 -1.0 8122800.0 -1480000.0 -1.23 7962560.0 -1187545.0 -0.998582426810267 -1.8624 -0.9951 3092516 BCB02_000097 CC(C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G02 compound treatment 8481480.0 -1230000.0 -1.06 8299720.0 -1300000.0 -1.08 7769720.0 -1380385.0 -1.16073765897923 -1.9027 -0.9992 3000862 BCB02_000098 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2C)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G03 compound treatment 8284400.0 -1420000.0 -1.22 9137360.0 -464000.0 -0.38 8767920.0 -382185.0 -0.321371589952786 -1.1148 -0.8424 3092587 BCB02_000099 CCCCCCCCCCC(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G04 compound treatment 8516440.0 -1190000.0 -1.03 8676880.0 -924000.0 -0.77 7817240.0 -1332865.0 -1.12077905789715 -1.6816 -0.9883 3000863 BCB02_000100 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)C[Si](C)(C)C)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G05 compound treatment 9546440.0 -161000.0 -0.14 1.011248E7 511000.0 0.42 9797720.0 647615.0 0.544566276089522 0.4793 0.6807 3092588 BCB02_000101 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G06 compound treatment 9388160.0 -319000.0 -0.27 9197400.0 -404000.0 -0.33 8138680.0 -1011425.0 -0.850486702429444 -0.8431 -0.8833 3092589 BCB02_000102 CCOC(=O)C1=CC[C@H](N([C@H]1/C=C/c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G07 compound treatment 1.002904E7 322000.0 0.28 9885800.0 285000.0 0.24 9482440.0 332335.0 0.279453739280608 0.4575 0.9972 3000864 BCB02_000103 COc1ccc(C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5)c6ccccc16 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G08 compound treatment 9808560.0 101000.0 0.09 9186160.0 -415000.0 -0.34 8301880.0 -848225.0 -0.713255143157639 -0.5603 -0.7033 3092590 BCB02_000104 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4cccc(Cl)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G09 compound treatment 1.088792E7 1180000.0 1.02 1.032812E7 727000.0 0.6 9436240.0 286135.0 0.240605099339693 1.0736 0.8905 3092591 BCB02_000105 COc1ccc(cc1OCc2ccccc2)C(O)C3C=CC4C(N3Nc5ccc(cc5)[N+](=O)[O-])C(=O)N(C4=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G10 compound treatment 9937360.0 230000.0 0.2 8687280.0 -914000.0 -0.76 7866000.0 -1284105.0 -1.07977776604608 -0.9469 -0.7098 3000865 BCB02_000106 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2I)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G11 compound treatment 1.068504E7 978000.0 0.84 9954000.0 353000.0 0.29 9364360.0 214255.0 0.180162669925126 0.7588 0.8349 3092592 BCB02_000107 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccccn5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G12 compound treatment 1.028468E7 577000.0 0.5 8667600.0 -934000.0 -0.77 8824320.0 -325785.0 -0.273945977557383 -0.3185 -0.3318 3000866 BCB02_000108 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G13 compound treatment 1.052696E7 819000.0 0.71 1.074332E7 1140000.0 0.95 9537640.0 387535.0 0.325870296093131 1.1424 0.9323 3092593 BCB02_000109 CCOc1cc(ccc1O)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G14 compound treatment 9931080.0 224000.0 0.19 9682760.0 81700.0 0.07 8702120.0 -447985.0 -0.376701471080757 -0.0673 -0.1571 3000867 BCB02_000110 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G15 compound treatment 9581160.0 -126000.0 -0.11 8886040.0 -715000.0 -0.59 7902080.0 -1248025.0 -1.04943882818746 -1.0112 -0.8354 3092594 BCB02_000111 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5cc(cc(c5)C(F)(F)F)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G16 compound treatment 1.022996E7 522000.0 0.45 9817360.0 216000.0 0.18 9413560.0 263455.0 0.221533948823244 0.4911 0.9224 3092595 BCB02_000112 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(SC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OCc5ccccc5)c(OC)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G17 mock treatment 1.024564E7 538000.0 0.46 1.019108E7 590000.0 0.49 9288960.0 138855.0 0.116760344134108 0.6174 0.9028 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G18 mock treatment 1.006464E7 357000.0 0.31 1.11296E7 1530000.0 1.27 9556840.0 406735.0 0.342015185419225 1.107 0.8207 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G19 mock treatment 9938480.0 231000.0 0.2 9435400.0 -166000.0 -0.14 9877840.0 727735.0 0.611937553839871 0.3887 0.5908 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G20 mock treatment 1.0528E7 820000.0 0.71 1.057696E7 976000.0 0.81 9905120.0 755015.0 0.634876750757364 1.2416 0.995 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G21 mock treatment 1.039104E7 684000.0 0.59 1.075592E7 1150000.0 0.96 9615360.0 465255.0 0.391223462677718 1.1186 0.9398 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G22 mock treatment 9766040.0 58500.0 0.05 9497680.0 -103000.0 -0.09 9109440.0 -40665.0 -0.0341943710648771 -0.0402 -0.3821 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G23 mock treatment 9959080.0 252000.0 0.22 9735400.0 134000.0 0.11 8978360.0 -171745.0 -0.144416875901569 0.1059 0.3742 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 G24 mock treatment 9907400.0 200000.0 0.17 9307840.0 -293000.0 -0.24 8529000.0 -621105.0 -0.522274556504377 -0.3427 -0.5699 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H01 compound treatment 9618880.0 -88600.0 -0.08 8369480.0 -1230000.0 -1.02 8430720.0 -719385.0 -0.604916208742324 -0.9832 -0.8263 3000868 BCB02_000113 CC(=CCC/C(=C/C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)/C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H02 compound treatment 8378880.0 -1330000.0 -1.14 9581080.0 -20000.0 -0.02 8119120.0 -1030985.0 -0.866934308430403 -1.1703 -0.8155 3092596 BCB02_000114 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccc(cc2)C(C)C)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H03 compound treatment 9835560.0 128000.0 0.11 9224800.0 -376000.0 -0.31 8576240.0 -573865.0 -0.482551401724965 -0.3952 -0.6753 3092597 BCB02_000115 OC(CCc1ccccc1)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H04 compound treatment 9609440.0 -98100.0 -0.08 8927440.0 -674000.0 -0.56 8998600.0 -151505.0 -0.127397471736978 -0.4449 -0.768 3000869 BCB02_000116 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccccc2F)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H05 compound treatment 1.003148E7 324000.0 0.28 1.010576E7 505000.0 0.42 9198720.0 48615.0 0.0408793643014632 0.4263 0.8447 3092598 BCB02_000117 COc1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccccc4F)C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H06 compound treatment 9745760.0 38200.0 0.03 9969840.0 369000.0 0.31 8499120.0 -650985.0 -0.547400040518112 -0.1204 -0.1918 3000870 BCB02_000118 CCOC(=O)C1=C[C@@H](CC)N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H07 compound treatment 1.00936E7 386000.0 0.33 1.060512E7 1000000.0 0.83 9903400.0 753295.0 0.633430437755234 1.0384 0.9458 3000871 BCB02_000119 O=c1cccc(o1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H08 compound treatment 9938840.0 231000.0 0.2 9869960.0 269000.0 0.22 8281080.0 -869025.0 -0.730745439927575 -0.1782 -0.2257 3092599 BCB02_000120 CCOC(=O)C1=CCN(C1c2ccccc2)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H09 compound treatment 1.041196E7 704000.0 0.61 9954480.0 353000.0 0.29 9715040.0 564935.0 0.475042346429026 0.7935 0.9629 3000872 BCB02_000121 COc1cccc(c1)c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H10 compound treatment 1.085636E7 1150000.0 0.99 9437280.0 -164000.0 -0.14 7840160.0 -1309945.0 -1.10150609626412 -0.1436 -0.0966 3092600 BCB02_000122 CCC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(=O)OCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H11 compound treatment 1.075044E7 1040000.0 0.9 1.05608E7 960000.0 0.8 9879120.0 729015.0 0.613013879794944 1.3318 0.9885 1984103 BCB02_000123 Cc1ccc(cc1)c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H12 compound treatment 1.107868E7 1370000.0 1.18 9571160.0 -29900.0 -0.02 8582480.0 -567625.0 -0.477304312693984 0.3914 0.3074 3092601 BCB02_000124 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H13 compound treatment 1.05294E7 822000.0 0.71 1.00594E7 458000.0 0.38 1.015388E7 1003775.0 0.844053973088578 1.1152 0.9572 3000873 BCB02_000125 Clc1cccc(c1)c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H14 compound treatment 1.051032E7 803000.0 0.69 1.05638E7 963000.0 0.8 9846400.0 696295.0 0.585500297568391 1.198 0.9922 3000874 BCB02_000126 Cc1ccc(cc1)[C@@H]2N(CC=C2C(=O)O)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H15 compound treatment 1.03518E7 644000.0 0.55 1.067552E7 1070000.0 0.89 9476800.0 326695.0 0.274711178041068 0.9933 0.9155 3000875 BCB02_000127 Clc1ccccc1c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H16 compound treatment 1.021968E7 512000.0 0.44 1.05084E7 907000.0 0.75 9709120.0 559015.0 0.470064338886814 0.9604 0.9693 3092602 BCB02_000128 C[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H17 mock treatment 1.054756E7 840000.0 0.72 1.031244E7 711000.0 0.59 9938160.0 788055.0 0.662659414472685 1.1407 0.9966 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H18 mock treatment 1.055712E7 850000.0 0.73 9901040.0 300000.0 0.25 9254840.0 104735.0 0.0880695303941941 0.6167 0.7933 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H19 mock treatment 1.073316E7 1030000.0 0.88 9653800.0 52700.0 0.04 9607840.0 457735.0 0.384900047691664 0.7571 0.7854 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H20 mock treatment 1.01036E7 396000.0 0.34 1.011632E7 515000.0 0.43 9617080.0 466975.0 0.392669775679847 0.6703 0.9958 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H21 mock treatment 1.014832E7 441000.0 0.38 1.01892E7 588000.0 0.49 9479040.0 328935.0 0.276594748462446 0.6604 0.9753 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H22 mock treatment 9919680.0 212000.0 0.18 9506200.0 -94900.0 -0.08 9251080.0 100975.0 0.0849078229011673 0.109 0.5041 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H23 mock treatment 9795680.0 88200.0 0.08 9865880.0 265000.0 0.22 9610480.0 460375.0 0.387119969974002 0.3941 0.8729 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 H24 mock treatment 9015240.0 -692000.0 -0.6 9465960.0 -135000.0 -0.11 8241120.0 -908985.0 -0.76434699083751 -0.85 -0.8713 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I01 compound treatment 8960720.0 -747000.0 -0.64 8640960.0 -960000.0 -0.8 8103680.0 -1046425.0 -0.879917490263471 -1.339 -0.992 3092603 BCB02_000129 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5cccs5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I02 compound treatment 8280680.0 -1430000.0 -1.23 8277240.0 -1320000.0 -1.1 7850040.0 -1300065.0 -1.0931982052984 -1.9742 -0.9985 3000947 BCB02_000130 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(cc2)[N+](=O)[O-])S(=O)(=O)c3ccc(C)cc3)c4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I03 compound treatment 8718480.0 -989000.0 -0.85 9146840.0 -454000.0 -0.38 7869800.0 -1280305.0 -1.07658242336696 -1.3306 -0.9349 3000948 BCB02_000131 OC(C(c1ccccc1)c2ccccc2)C3C=CC4C(N3Nc5ccc(cc5)[N+](=O)[O-])C(=O)N(C4=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I04 compound treatment 8967880.0 -740000.0 -0.64 8431480.0 -1170000.0 -0.97 7824720.0 -1325385.0 -1.11448927809719 -1.5712 -0.9765 3000949 BCB02_000132 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(cc2)[N+](=O)[O-])S(=O)(=O)c3ccc(C)cc3)c4cccc(Br)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I05 compound treatment 9552320.0 -155000.0 -0.13 9299400.0 -302000.0 -0.25 8781360.0 -368745.0 -0.31007016742452 -0.4006 -0.9533 3000950 BCB02_000133 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5cccc6ccccc56 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I06 compound treatment 9403200.0 -304000.0 -0.26 9340440.0 -261000.0 -0.22 7643560.0 -1506545.0 -1.26682303592611 -1.0075 -0.7681 3000951 BCB02_000134 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I07 compound treatment 1.081456E7 1110000.0 0.95 1.076112E7 1160000.0 0.96 9294280.0 144175.0 0.12123382388488 1.1757 0.8647 3092604 BCB02_000135 C/C=C/C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I08 compound treatment 9690120.0 -17400.0 -0.01 8515800.0 -1090000.0 -0.9 8178280.0 -971825.0 -0.817187868194374 -1.0003 -0.8226 3000952 BCB02_000136 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccc4ccccc34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I09 compound treatment 1.01506E7 443000.0 0.38 9968920.0 368000.0 0.31 9662160.0 512055.0 0.430576630410074 0.6449 0.9905 3092605 BCB02_000137 CCC(CC)C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I10 compound treatment 9666080.0 -41400.0 -0.04 8940520.0 -661000.0 -0.55 8416880.0 -733225.0 -0.616553983131551 -0.6929 -0.8393 3092606 BCB02_000138 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(F)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I11 compound treatment 1.074208E7 1030000.0 0.89 9987680.0 387000.0 0.32 9222440.0 72335.0 0.0608250296564093 0.7343 0.7743 3000953 BCB02_000139 CC(C)C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I12 compound treatment 9590320.0 -117000.0 -0.1 8764920.0 -836000.0 -0.69 7155800.0 -1994305.0 -1.67697049518111 -1.4269 -0.7851 3092607 BCB02_000140 CCOC(=O)[C@@H]1N([C@@H](CC=C1C(=O)OCC)c2ccccc2)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I13 compound treatment 1.00772E7 370000.0 0.32 1.101932E7 1420000.0 1.18 9778760.0 628655.0 0.528623197880003 1.1682 0.8793 3092678 BCB02_000141 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5cccc(O)c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I14 compound treatment 1.013596E7 428000.0 0.37 9366560.0 -235000.0 -0.19 8904440.0 -245665.0 -0.206574699807034 -0.0187 -0.0402 3000954 BCB02_000142 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OC)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I15 compound treatment 1.054752E7 840000.0 0.72 1.028876E7 688000.0 0.57 9419760.0 269655.0 0.226747402668128 0.8777 0.9254 3092679 BCB02_000143 OB(O)c1ccc(cc1)C(O)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I16 compound treatment 9410760.0 -297000.0 -0.26 8407320.0 -1190000.0 -0.99 7147840.0 -2002265.0 -1.68366389721422 -1.6913 -0.8585 3000955 BCB02_000144 CCOC(=O)C1=CC[C@H](N([C@H]1C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I17 mock treatment 1.06362E7 929000.0 0.8 9958400.0 357000.0 0.3 9776040.0 625935.0 0.526336005225473 0.9365 0.9347 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I18 mock treatment 1.047508E7 768000.0 0.66 1.019556E7 594000.0 0.49 9506040.0 355935.0 0.299298499077266 0.8389 0.9566 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I19 mock treatment 1.04168E7 709000.0 0.61 1.041656E7 815000.0 0.68 9422040.0 271935.0 0.228664608275602 0.875 0.9314 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I20 mock treatment 9809560.0 102000.0 0.09 9890480.0 289000.0 0.24 9331800.0 181695.0 0.152783628442957 0.2775 0.9319 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I21 mock treatment 1.003676E7 329000.0 0.28 9830560.0 229000.0 0.19 8795760.0 -354345.0 -0.297961500429949 0.1015 0.2239 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I22 mock treatment 1.01302E7 423000.0 0.36 1.029156E7 690000.0 0.57 8460960.0 -689145.0 -0.579488008053725 0.2062 0.231 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I23 mock treatment 9892240.0 185000.0 0.16 9739400.0 138000.0 0.11 9052800.0 -97305.0 -0.0818217945768565 0.1108 0.5215 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 I24 mock treatment 9420280.0 -287000.0 -0.25 8841200.0 -760000.0 -0.63 7816280.0 -1333825.0 -1.12158630236345 -1.1542 -0.881 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J01 compound treatment 8798360.0 -909000.0 -0.78 8874400.0 -727000.0 -0.6 8121280.0 -1028825.0 -0.865118008381217 -1.2993 -0.9895 3000956 BCB02_000145 CCCc1cccc(=O)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J02 compound treatment 9809400.0 102000.0 0.09 9032920.0 -568000.0 -0.47 8555040.0 -595065.0 -0.500378050355861 -0.5104 -0.7365 3092680 BCB02_000146 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J03 compound treatment 9455120.0 -252000.0 -0.22 9657000.0 55900.0 0.05 8206000.0 -944105.0 -0.793878684229824 -0.557 -0.6757 3000957 BCB02_000147 Fc1ccc(cc1)c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J04 compound treatment 9783880.0 76400.0 0.07 1.044044E7 839000.0 0.7 8779400.0 -370705.0 -0.311718291543226 0.26 0.3395 3092681 BCB02_000148 CCC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J05 compound treatment 9950320.0 243000.0 0.21 9965480.0 364000.0 0.3 9257640.0 107535.0 0.0904239934209163 0.3474 0.9179 3000958 BCB02_000149 O=c1cccc(o1)c2ccc(C#N)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J06 compound treatment 9472000.0 -236000.0 -0.2 1.007136E7 470000.0 0.39 8740120.0 -409985.0 -0.344748044289528 -0.0908 -0.1626 3000959 BCB02_000150 CC(C)[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J07 compound treatment 9724440.0 16900.0 0.01 9756680.0 156000.0 0.13 8648000.0 -502105.0 -0.422209877868686 -0.1608 -0.3641 3092682 BCB02_000151 FC(F)(F)c1ccc(cc1)c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J08 compound treatment 1.013964E7 432000.0 0.37 9852880.0 252000.0 0.21 9111880.0 -38225.0 -0.0321426247130192 0.3167 0.7405 3092683 BCB02_000152 Cc1ccc(cc1)[C@@H]2N([C@@H](C=C2C(=O)O)C(C)(C)C)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J09 compound treatment 1.035828E7 651000.0 0.56 1.011324E7 512000.0 0.42 9528000.0 377895.0 0.317764216243987 0.7521 0.9749 3000960 BCB02_000153 FC(F)(F)c1ccccc1c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J10 compound treatment 1.066548E7 958000.0 0.82 1.071832E7 1120000.0 0.93 9423760.0 273655.0 0.230110921277731 1.144 0.9067 3092684 BCB02_000154 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J11 compound treatment 1.023036E7 523000.0 0.45 1.012092E7 520000.0 0.43 9503080.0 352975.0 0.29680949530616 0.6801 0.9852 3000961 BCB02_000155 O=c1cccc(o1)c2ccc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J12 compound treatment 1.042392E7 716000.0 0.62 1.063156E7 1030000.0 0.85 9716840.0 566735.0 0.476555929803348 1.1247 0.9723 3000962 BCB02_000156 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C#N)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J13 compound treatment 1.087912E7 1170000.0 1.01 1.006384E7 463000.0 0.38 1.007412E7 924015.0 0.776985412013093 1.2524 0.9419 3092685 BCB02_000157 O=c1cccc(o1)c2ccco2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J14 compound treatment 1.071936E7 1010000.0 0.87 1.044588E7 845000.0 0.7 1.000092E7 850815.0 0.715433021457357 1.3204 0.9949 3092686 BCB02_000158 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(OC)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J15 compound treatment 1.011572E7 408000.0 0.35 9889800.0 289000.0 0.24 9494160.0 344055.0 0.289308848806745 0.5081 0.9881 3000963 BCB02_000159 O=c1cccc(CCc2ccccc2)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J16 compound treatment 1.052492E7 817000.0 0.7 1.022352E7 622000.0 0.52 9312120.0 162015.0 0.13623511688371 0.7829 0.8864 3092687 BCB02_000160 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3cccc(Cl)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J17 mock treatment 9860880.0 153000.0 0.13 9876040.0 275000.0 0.23 9968480.0 818375.0 0.688154885533476 0.6052 0.8213 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J18 mock treatment 1.057044E7 863000.0 0.74 9666720.0 65600.0 0.05 9720680.0 570575.0 0.479784907668567 0.7372 0.8322 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J19 mock treatment 9711160.0 3650.0 0.0 1.0215E7 614000.0 0.51 9690840.0 540735.0 0.454693058840928 0.5584 0.8178 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J20 mock treatment 1.015056E7 443000.0 0.38 9932760.0 332000.0 0.28 1.097476E7 1824655.0 1.53431526215132 1.2648 0.7882 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J21 mock treatment 9578640.0 -129000.0 -0.11 9570240.0 -30900.0 -0.03 9225480.0 75375.0 0.0633813037997077 -0.0422 -0.3241 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J22 mock treatment 8933200.0 -774000.0 -0.67 9238000.0 -363000.0 -0.3 9142040.0 -8065.0 -0.00678169439661217 -0.5626 -0.7692 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J23 mock treatment 9034400.0 -673000.0 -0.58 9080040.0 -521000.0 -0.43 8664280.0 -485825.0 -0.408520357127602 -0.8199 -0.9875 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 J24 mock treatment 8196440.0 -1510000.0 -1.3 9325040.0 -276000.0 -0.23 8860320.0 -289785.0 -0.243674310070956 -1.0237 -0.7624 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K01 compound treatment 8774600.0 -933000.0 -0.8 8728040.0 -873000.0 -0.72 8118120.0 -1031985.0 -0.867775188082804 -1.3827 -0.9973 3000964 BCB02_000161 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccc(C#N)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K02 compound treatment 3770400.0 -5940000.0 -5.11 5576320.0 -4020000.0 -3.34 3184960.0 -5965145.0 -5.01596905412016 -7.7737 -0.984 3092688 BCB02_000162 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccncc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K03 compound treatment 9500280.0 -207000.0 -0.18 9415240.0 -186000.0 -0.15 8686080.0 -464025.0 -0.390189180705265 -0.4173 -0.9153 3092689 BCB02_000163 CC(C(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K04 compound treatment 9185760.0 -522000.0 -0.45 7193480.0 -2410000.0 -2.0 7365240.0 -1784865.0 -1.50085666078229 -2.2789 -0.8978 3000965 BCB02_000164 CCOC(=O)C1=CC[C@H](N([C@H]1C=C(C)C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K05 compound treatment 9687160.0 -20400.0 -0.02 9653960.0 52900.0 0.04 9094000.0 -56105.0 -0.0471775528979449 -0.012 -0.1804 3092690 BCB02_000165 CC(CC(O)C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(C)o5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K06 compound treatment 1.0479E7 771000.0 0.66 9533600.0 -67500.0 -0.06 7334320.0 -1815785.0 -1.52685665963452 -0.5305 -0.3185 3000966 BCB02_000166 CCOC(=O)C1=CC[C@H](N([C@H]1C#N)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K07 compound treatment 9422200.0 -285000.0 -0.25 9961880.0 361000.0 0.3 9305600.0 155495.0 0.130752581550057 0.1065 0.2607 3092691 BCB02_000167 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5cccs5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K08 compound treatment 9435360.0 -272000.0 -0.23 8168000.0 -1430000.0 -1.19 7627840.0 -1522265.0 -1.28004166406185 -1.5607 -0.8854 3092692 BCB02_000168 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(OC)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K09 compound treatment 9729480.0 22000.0 0.02 9840200.0 239000.0 0.2 8825200.0 -324905.0 -0.273206003463271 -0.0323 -0.0955 3000967 BCB02_000169 OC(Cc1ccccc1)C2C=CC3C(N2Nc4ccc(cc4)[N+](=O)[O-])C(=O)N(C3=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K10 compound treatment 9791200.0 83700.0 0.07 9346080.0 -255000.0 -0.21 9080360.0 -69745.0 -0.0586471513566914 -0.1144 -0.4952 3092693 BCB02_000170 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K11 compound treatment 1.041612E7 709000.0 0.61 1.070844E7 1110000.0 0.92 9513880.0 363775.0 0.305890995552088 1.0591 0.9255 3000968 BCB02_000171 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc(C#N)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K12 compound treatment 1.023956E7 532000.0 0.46 9391360.0 -210000.0 -0.17 8612600.0 -537505.0 -0.451977017563673 -0.097 -0.1456 3092694 BCB02_000172 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(cc4)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K13 compound treatment 1.080744E7 1100000.0 0.95 1.059544E7 994000.0 0.82 1.020836E7 1058255.0 0.889865096551372 1.5365 0.9984 3092695 BCB02_000173 OC(C1C=CC2C(N1Nc3ccc(cc3)[N+](=O)[O-])C(=O)N(C2=O)c4ccccc4)c5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K14 compound treatment 9678640.0 -28900.0 -0.02 8674320.0 -927000.0 -0.77 7228080.0 -1922025.0 -1.61619171390558 -1.3913 -0.7773 3000969 BCB02_000174 CCOC(=O)C1=CC[C@H](N([C@H]1C=C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K15 compound treatment 1.032112E7 614000.0 0.53 9590840.0 -10300.0 -0.01 9469520.0 319415.0 0.26858957417159 0.455 0.768 3092696 BCB02_000175 CC1(C)[C@H]2C[C@@H]1C=C(C2)C(O)C3C=CC4C(N3Nc5ccc(cc5)[N+](=O)[O-])C(=O)N(C4=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K16 compound treatment 1.032276E7 615000.0 0.53 8740600.0 -861000.0 -0.71 8701440.0 -448665.0 -0.377273269244389 -0.3243 -0.3358 3000970 BCB02_000176 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(cc2)[N+](=O)[O-])S(=O)(=O)c3ccc(C)cc3)c4ccc(cc4)N(CC)CC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K17 mock treatment 1.022532E7 518000.0 0.45 1.011516E7 514000.0 0.43 8993760.0 -156345.0 -0.131467329254598 0.4276 0.678 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K18 mock treatment 1.096888E7 1260000.0 1.09 9979800.0 379000.0 0.31 9272360.0 122255.0 0.102801741904256 0.8675 0.7644 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K19 mock treatment 1.043724E7 730000.0 0.63 9948800.0 348000.0 0.29 9996120.0 846015.0 0.711396799125833 0.9398 0.9476 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K20 mock treatment 9933160.0 226000.0 0.19 9722720.0 122000.0 0.1 9317440.0 167335.0 0.140708596634482 0.2516 0.9671 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K21 mock treatment 9656800.0 -50700.0 -0.04 9971520.0 370000.0 0.31 8951680.0 -198425.0 -0.166851545027622 0.0559 0.1586 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K22 mock treatment 9514920.0 -193000.0 -0.17 9237360.0 -364000.0 -0.3 8524840.0 -625265.0 -0.525772615858364 -0.5735 -0.9125 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K23 mock treatment 9810880.0 103000.0 0.09 9191880.0 -409000.0 -0.34 9253080.0 102975.0 0.0865895822059688 -0.0946 -0.2618 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 K24 mock treatment 9008440.0 -699000.0 -0.6 9751800.0 151000.0 0.13 8423200.0 -726905.0 -0.611239623728378 -0.6281 -0.7247 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L01 compound treatment 1.027316E7 566000.0 0.49 9243720.0 -357000.0 -0.3 8903440.0 -246665.0 -0.207415579459435 -0.0099 -0.0163 3000971 BCB02_000177 [O-][N+](=O)c1ccc(cc1)c2cccc(=O)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L02 compound treatment 8257120.0 -1450000.0 -1.25 9612840.0 11700.0 0.01 8775840.0 -374265.0 -0.314711823105772 -0.8968 -0.6966 3092697 BCB02_000178 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(cc2)[N+](=O)[O-])c3ccccc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L03 compound treatment 9446520.0 -261000.0 -0.22 9581600.0 -19500.0 -0.02 9511360.0 361255.0 0.303771978828038 0.0364 0.0961 3000972 BCB02_000179 O=c1cccc(/C=C/c2ccccc2)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L04 compound treatment 1.016884E7 461000.0 0.4 1.056048E7 959000.0 0.8 9208960.0 58855.0 0.049489971942047 0.7173 0.8052 3092698 BCB02_000180 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccco3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L05 compound treatment 9813320.0 106000.0 0.09 9815440.0 214000.0 0.18 9888920.0 738815.0 0.621254500388471 0.5139 0.7875 3000973 BCB02_000181 O=c1cccc(o1)c2cccc3ccccc23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L06 compound treatment 1.046776E7 760000.0 0.65 1.057856E7 977000.0 0.81 1.007128E7 921175.0 0.774597313800275 1.2931 0.996 3092699 BCB02_000182 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3cccc4ccccc34)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L07 compound treatment 1.00408E7 333000.0 0.29 9641120.0 40000.0 0.03 9306680.0 156575.0 0.13166073157465 0.2608 0.8217 3000974 BCB02_000183 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(Cl)c2)c3cccc(Cl)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L08 compound treatment 1.006932E7 362000.0 0.31 1.055212E7 951000.0 0.79 9484440.0 334335.0 0.28113549858541 0.7976 0.8926 3092700 BCB02_000184 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(Br)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L09 compound treatment 9311800.0 -396000.0 -0.34 9227560.0 -374000.0 -0.31 8564840.0 -585265.0 -0.492137429762334 -0.6597 -0.9788 3092701 BCB02_000185 CCOC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(c2)[N+](=O)[O-])c3cccc(c3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L10 compound treatment 1.01766E7 469000.0 0.4 1.029388E7 693000.0 0.57 9459480.0 309375.0 0.260147142461487 0.7151 0.9548 3000975 BCB02_000186 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(cc3)C(C)C)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L11 compound treatment 1.022004E7 513000.0 0.44 9968120.0 367000.0 0.3 9098240.0 -51865.0 -0.0436122231717657 0.4053 0.7537 3092771 BCB02_000187 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccccn2)c3ccccn3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L12 compound treatment 1.022932E7 522000.0 0.45 1.081084E7 1210000.0 1.0 9594680.0 444575.0 0.37383407146607 1.0545 0.9081 3000976 BCB02_000188 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](C=C([C@@H]2c3ccccc3)C(=O)O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L13 compound treatment 7308760.0 -2400000.0 -2.06 6838320.0 -2760000.0 -2.29 7342240.0 -1807865.0 -1.52019689278751 -3.3928 -0.9866 3092772 BCB02_000189 COC(=O)c1cccc(c1)[C@@H]2C/C(=C\C(=O)OC(C)C)/O[C@@H](O2)c3cccc(c3)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L14 compound treatment 1.005888E7 351000.0 0.3 1.023552E7 634000.0 0.53 9791000.0 640895.0 0.538915564825388 0.7896 0.9728 3092773 BCB02_000190 CC(C)[C@@H]1[C@@H](Sc2ccccc2)[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L15 compound treatment 8915240.0 -792000.0 -0.68 9100840.0 -500000.0 -0.42 6741640.0 -2408465.0 -2.02522921201941 -1.8025 -0.828 3000977 BCB02_000191 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2ccc(C#N)cc2)c3ccc(C#N)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L16 compound treatment 9973960.0 266000.0 0.23 1.057508E7 974000.0 0.81 9501960.0 351855.0 0.295867710095471 0.7697 0.8644 3092774 BCB02_000192 CC[C@@H]1C(Sc2ccccc2)C([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L17 mock treatment 9980600.0 273000.0 0.24 1.01508E7 550000.0 0.46 9803000.0 652895.0 0.549006120654198 0.7159 0.9528 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L18 mock treatment 1.009844E7 391000.0 0.34 9938400.0 337000.0 0.28 9657040.0 506935.0 0.426271326589782 0.6019 0.9853 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L19 mock treatment 9991240.0 284000.0 0.24 1.025888E7 658000.0 0.55 9770120.0 620015.0 0.52135799768326 0.757 0.9544 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L20 mock treatment 9629120.0 -78400.0 -0.07 1.027012E7 669000.0 0.55 9374760.0 224655.0 0.188907818310094 0.3905 0.6618 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L21 mock treatment 9678560.0 -29000.0 -0.02 1.028416E7 683000.0 0.57 9194360.0 44255.0 0.0372131290169959 0.3342 0.588 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L22 mock treatment 1.000888E7 301000.0 0.26 1.022376E7 623000.0 0.52 8096520.0 -1053585.0 -0.88593818857466 -0.0635 -0.0601 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L23 mock treatment 9256400.0 -451000.0 -0.39 9817480.0 216000.0 0.18 8894120.0 -255985.0 -0.21525257781981 -0.2448 -0.5112 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 L24 mock treatment 9027960.0 -680000.0 -0.58 8846280.0 -755000.0 -0.63 8856680.0 -293425.0 -0.246735112005695 -0.8416 -0.9439 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M01 compound treatment 8251360.0 -1460000.0 -1.25 8178320.0 -1420000.0 -1.18 8272160.0 -877945.0 -0.73824608642699 -1.8312 -0.9776 3000978 BCB02_000193 CC1(C)[C@H]2C[C@H]1C=C(C2)C(O)C3C=CC4C(N3Nc5ccccc5F)C(=O)N(C4=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M02 compound treatment 8014400.0 -1690000.0 -1.46 8165600.0 -1440000.0 -1.19 8187200.0 -962905.0 -0.809687221694959 -1.9963 -0.9744 3001047 BCB02_000194 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(c(OC)c4)c5ccc(OCc6ccccc6)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M03 compound treatment 7278080.0 -2430000.0 -2.09 8221320.0 -1380000.0 -1.14 7824600.0 -1325505.0 -1.11459018365548 -2.5115 -0.9544 3092775 BCB02_000195 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(I)cc4)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M04 compound treatment 8635480.0 -1070000.0 -0.92 8682680.0 -918000.0 -0.76 7975840.0 -1174265.0 -0.987415545026385 -1.5427 -0.9944 3001048 BCB02_000196 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M05 compound treatment 9391440.0 -316000.0 -0.27 9605800.0 4690.0 0.0 8479800.0 -670305.0 -0.563645835402495 -0.4802 -0.7673 3092776 BCB02_000197 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(cc4)[N+](=O)[O-])C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M06 compound treatment 8194360.0 -1510000.0 -1.3 8675040.0 -926000.0 -0.77 7704360.0 -1445745.0 -1.21569755306014 -1.8973 -0.9779 3001049 BCB02_000198 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M07 compound treatment 9168560.0 -539000.0 -0.46 9161680.0 -439000.0 -0.36 9081640.0 -68465.0 -0.0575708254016184 -0.5115 -0.8629 3092777 BCB02_000199 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(OC)cc4)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M08 compound treatment 8698680.0 -1010000.0 -0.87 8644200.0 -957000.0 -0.79 8056080.0 -1094025.0 -0.919943361717747 -1.4907 -0.9982 3092778 BCB02_000200 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(CC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M09 compound treatment 1.029288E7 585000.0 0.5 1.024968E7 649000.0 0.54 9440160.0 290055.0 0.243901347577104 0.7423 0.9561 3001050 BCB02_000201 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(cc4)N(C)C)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M10 compound treatment 7451760.0 -2260000.0 -1.94 7779720.0 -1820000.0 -1.51 7174080.0 -1976025.0 -1.66159921513522 -2.9525 -0.9946 3001168 BCB02_000202 CCOC(=O)C1=C(N([C@@H](CC1)c2ccccc2)S(=O)(=O)CC[Si](C)(C)C)C(=O)OCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M11 compound treatment 1.058184E7 874000.0 0.75 1.003688E7 436000.0 0.36 9917520.0 767415.0 0.645303658447133 1.0157 0.9626 3092779 BCB02_000203 COc1ccc(NN2C3C(C=CC2C(O)c4cc(OC)c(OC)c(OC)c4)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M12 compound treatment 8905680.0 -802000.0 -0.69 9029440.0 -572000.0 -0.47 8225480.0 -924625.0 -0.777498348601057 -1.1211 -0.9812 3092780 BCB02_000204 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)c4cc(Cl)ccc4Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M13 compound treatment 1.059604E7 889000.0 0.76 9844800.0 244000.0 0.2 9524840.0 374735.0 0.315107036542401 0.7401 0.8693 3001169 BCB02_000205 COc1ccc(NN2C3C(C=CC2C(O)C4=CC[C@H](CC4)C(=C)C)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M14 compound treatment 1.00358E7 328000.0 0.28 1.00408E7 440000.0 0.36 9056680.0 -93425.0 -0.0785591815255415 0.3284 0.7016 3092781 BCB02_000206 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(cc2)[N+](=O)[O-])c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M15 compound treatment 1.01402E7 433000.0 0.37 9559080.0 -42000.0 -0.03 9494200.0 344095.0 0.289342483992841 0.3619 0.7654 3001170 BCB02_000207 COc1ccc(NN2C3C(C=CC2C(O)c4ccco4)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M16 mock treatment 9540800.0 -167000.0 -0.14 9721320.0 120000.0 0.1 9607880.0 457775.0 0.38493368287776 0.197 0.466 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M17 mock treatment 9982800.0 275000.0 0.24 1.02028E7 602000.0 0.5 9216200.0 66095.0 0.0555779406254286 0.4571 0.8231 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M18 mock treatment 9113840.0 -594000.0 -0.51 9526480.0 -74600.0 -0.06 9430120.0 280015.0 0.235458915867 -0.1948 -0.3442 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M19 mock treatment 1.006148E7 354000.0 0.3 9745760.0 145000.0 0.12 9260800.0 110695.0 0.0930811731225027 0.2989 0.8781 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M20 mock treatment 9664160.0 -43400.0 -0.04 9554920.0 -46200.0 -0.04 9434720.0 284615.0 0.239326962268044 0.0945 0.3854 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M21 mock treatment 9462080.0 -245000.0 -0.21 9779600.0 178000.0 0.15 9535080.0 384975.0 0.323717644182985 0.1504 0.3634 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M22 mock treatment 9744440.0 36900.0 0.03 9202160.0 -399000.0 -0.33 9077960.0 -72145.0 -0.0606652625224532 -0.2078 -0.6147 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M23 mock treatment 9543240.0 -164000.0 -0.14 9154360.0 -447000.0 -0.37 8446920.0 -703185.0 -0.591293958373432 -0.637 -0.8946 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 M24 mock treatment 8753480.0 -954000.0 -0.82 9220800.0 -380000.0 -0.32 7675640.0 -1474465.0 -1.23984761667709 -1.372 -0.9025 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N01 compound treatment 7482160.0 -2230000.0 -1.92 8118080.0 -1480000.0 -1.23 7279480.0 -1870625.0 -1.57297049977218 -2.7242 -0.9846 3092782 BCB02_000208 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccc(cc2)C(F)(F)F)c3ccc(cc3)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N02 compound treatment 8846240.0 -861000.0 -0.74 9216360.0 -385000.0 -0.32 8811440.0 -338665.0 -0.284776507480305 -0.7767 -0.9075 3092783 BCB02_000209 CCC[C@@H]1[C@@H](Sc2ccccc2)[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N03 compound treatment 9345000.0 -363000.0 -0.31 8692760.0 -908000.0 -0.75 7187920.0 -1962185.0 -1.649961440746 -1.5678 -0.8518 3001171 BCB02_000210 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2ccc([Ac])cc2)c3ccc([Ac])cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N04 compound treatment 9412600.0 -295000.0 -0.25 9400200.0 -201000.0 -0.17 8818440.0 -331665.0 -0.2788903499135 -0.4038 -0.9794 3092784 BCB02_000211 CCS[C@@H]1[C@@H](CC)N([C@H]([C@@H]1C(=O)O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N05 compound treatment 6863640.0 -2840000.0 -2.45 6925480.0 -2680000.0 -2.22 5123640.0 -4026465.0 -3.38577248960385 -4.6494 -0.9828 3001172 BCB02_000212 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccc([Ac])cc2)c3ccc([Ac])cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N06 compound treatment 9900800.0 193000.0 0.17 9768200.0 167000.0 0.14 8734120.0 -415985.0 -0.349793322203932 -0.0259 -0.0629 3092785 BCB02_000213 CCOC1=C2C(N(CC2C3C(C1)C(=O)N(C3=O)c4ccccc4)S(=O)(=O)c5ccc(C)cc5)c6ccc(C)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N07 compound treatment 6728360.0 -2980000.0 -2.56 6108200.0 -3490000.0 -2.9 5797360.0 -3352745.0 -2.8192550501884 -4.7809 -0.9987 3092786 BCB02_000214 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(c2)C(F)(F)F)c3cccc(c3)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N08 compound treatment 9915480.0 208000.0 0.18 9875000.0 274000.0 0.23 8556040.0 -594065.0 -0.499537170703461 -0.0539 -0.0934 3001173 BCB02_000215 CCOC1=C2C(N(CC2n3n(C1)c(=O)n(c4ccccc4)c3=O)S(=O)(=O)c5ccc(C)cc5)c6ccc(C)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N09 compound treatment 6973080.0 -2730000.0 -2.35 7291680.0 -2310000.0 -1.92 7646480.0 -1503625.0 -1.2643676673411 -3.1948 -0.9718 3092787 BCB02_000216 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2cccc(c2)C(F)(F)F)c3cccc(c3)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N10 compound treatment 1.021552E7 508000.0 0.44 1.027256E7 671000.0 0.56 9129880.0 -20225.0 -0.0170067909698055 0.5642 0.7965 3001174 BCB02_000217 Cc1ccc(cc1)C2C3C(CN2S(=O)(=O)c4ccc(C)cc4)C5C(CC3=O)C(=O)N(C5=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N11 compound treatment 9231000.0 -477000.0 -0.41 9118560.0 -483000.0 -0.4 8477760.0 -672345.0 -0.565361229893392 -0.7943 -0.9867 3092788 BCB02_000218 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccccc2C(F)(F)F)c3ccccc3C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N12 compound treatment 1.057864E7 871000.0 0.75 1.02048E7 604000.0 0.5 9197600.0 47495.0 0.0399375790907743 0.7451 0.8256 3092789 BCB02_000219 CCN1C(=O)C2CC(=O)C3C(N(CC3C2C1=O)S(=O)(=O)c4ccc(C)cc4)c5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N13 compound treatment 7815960.0 -1890000.0 -1.63 7492680.0 -2110000.0 -1.75 7501600.0 -1648505.0 -1.38619431138092 -2.7501 -0.9955 3001175 BCB02_000220 CON(C)C(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(Cl)c2)c3cccc(Cl)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N14 compound treatment 1.016708E7 460000.0 0.4 1.03878E7 787000.0 0.65 9102680.0 -47425.0 -0.0398787175151063 0.5821 0.7618 3092790 BCB02_000221 CC[C@@H]1[C@@H]2[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)CC5C2C(=O)N(CC)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N15 compound treatment 1.004588E7 338000.0 0.29 9934960.0 334000.0 0.28 9163120.0 13015.0 0.010944048675996 0.3343 0.8317 3001176 BCB02_000222 CC(C)OC(=O)CC(=O)CC(O)c1ccc(cc1)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N16 mock treatment 9604080.0 -103000.0 -0.09 9826320.0 225000.0 0.19 9508080.0 357975.0 0.301013893568164 0.2303 0.6303 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N17 mock treatment 9851240.0 144000.0 0.12 9735640.0 135000.0 0.11 9382160.0 232055.0 0.19513032773786 0.2485 0.9686 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N18 mock treatment 9811040.0 104000.0 0.09 9672640.0 71500.0 0.06 9083080.0 -67025.0 -0.0563599587021613 0.0532 0.4394 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N19 mock treatment 9488560.0 -219000.0 -0.19 9765560.0 164000.0 0.14 9214320.0 64215.0 0.0539970868789151 0.0011 0.0048 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N20 mock treatment 9299280.0 -408000.0 -0.35 9365200.0 -236000.0 -0.2 9265520.0 115415.0 0.0970501250818343 -0.2598 -0.628 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N21 mock treatment 9385600.0 -322000.0 -0.28 9490680.0 -110000.0 -0.09 9088440.0 -61665.0 -0.0518528437652932 -0.2428 -0.8192 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N22 mock treatment 8464640.0 -1240000.0 -1.07 8586520.0 -1010000.0 -0.84 8678400.0 -471705.0 -0.396647136435703 -1.3325 -0.9399 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N23 mock treatment 8952880.0 -755000.0 -0.65 8970400.0 -631000.0 -0.52 8572520.0 -577585.0 -0.485679474031896 -0.9575 -0.9921 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 N24 mock treatment 7893040.0 -1810000.0 -1.56 8293680.0 -1310000.0 -1.08 7767920.0 -1382185.0 -1.16225124235355 -2.1988 -0.9867 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O01 compound treatment 8243600.0 -1460000.0 -1.26 8413040.0 -1190000.0 -0.99 7969240.0 -1180865.0 -0.99296535073223 -1.8697 -0.9931 3092791 BCB02_000223 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccc(Br)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O02 compound treatment 7716960.0 -1990000.0 -1.71 7096480.0 -2500000.0 -2.08 6751440.0 -2398665.0 -2.01698859142588 -3.3532 -0.9966 3001177 BCB02_000224 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccco3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O03 compound treatment 9158480.0 -549000.0 -0.47 8554560.0 -1050000.0 -0.87 8162920.0 -987185.0 -0.830103779655249 -1.2533 -0.971 3092792 BCB02_000225 COc1ccc(NN2C3C(C=CC2C(O)c4ccc(OC)c(OCc5ccccc5)c4)C(=O)N(C6CCCCC6)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O04 compound treatment 9267120.0 -440000.0 -0.38 9559320.0 -41800.0 -0.03 6713440.0 -2436665.0 -2.04894201821711 -1.4218 -0.6822 3001178 BCB02_000226 CCOC(=O)C1=CC[C@H](N([C@@H]1C#N)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O05 compound treatment 9533520.0 -174000.0 -0.15 9542840.0 -58300.0 -0.05 8434320.0 -715785.0 -0.601889041993682 -0.4619 -0.7424 3092860 BCB02_000227 COc1ccc(NN2C3C(C=CC2C(O)c4ccccn4)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O06 compound treatment 9839160.0 132000.0 0.11 9108840.0 -492000.0 -0.41 7771680.0 -1378425.0 -1.15908953486052 -0.8396 -0.6803 3001179 BCB02_000228 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)CC[Si](C)(C)C)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O07 compound treatment 9863000.0 155000.0 0.13 9680360.0 79300.0 0.07 8983120.0 -166985.0 -0.140414288756142 0.0341 0.1667 3092861 BCB02_000229 CCOc1cc(ccc1O)C(O)C2C=CC3C(N2Nc4ccc(OC)cc4)C(=O)N(C5CCCCC5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O08 compound treatment 7404280.0 -2300000.0 -1.98 4364120.0 -5240000.0 -4.34 3424640.0 -5725465.0 -4.81442701903275 -6.4323 -0.9486 3001245 BCB02_000230 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccn3C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O09 compound treatment 9002040.0 -705000.0 -0.61 9385320.0 -216000.0 -0.18 8377880.0 -772225.0 -0.649348289575181 -0.8288 -0.914 3092862 BCB02_000231 COc1ccc(NN2C3C(C=CC2C(O)c4cc(cc(c4)C(F)(F)F)C(F)(F)F)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O10 compound treatment 9394080.0 -313000.0 -0.27 8165360.0 -1440000.0 -1.19 5302880.0 -3847225.0 -3.23505322070753 -2.7112 -0.7841 3001246 BCB02_000232 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(C#N)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O11 compound treatment 1.013664E7 429000.0 0.37 9218440.0 -383000.0 -0.32 9251560.0 101455.0 0.0853114451343196 0.0792 0.1602 3092863 BCB02_000233 Cc1ccc(NN2C3C(C=CC2C(O)c4c(F)cccc4Cl)C(=O)N(C5CCCCC5)C3=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O12 compound treatment 1.030984E7 602000.0 0.52 9077360.0 -524000.0 -0.43 9500280.0 350175.0 0.294455032279438 0.2184 0.2961 3001247 BCB02_000234 CCOC(=O)C1=CCC(NC1)c2cc3ccccc3[nH]2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O13 compound treatment 1.067244E7 965000.0 0.83 1.05228E7 922000.0 0.76 9267040.0 116935.0 0.0983282621534835 0.9777 0.8628 3092864 BCB02_000235 OC(C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O14 compound treatment 8830960.0 -877000.0 -0.75 8321080.0 -1280000.0 -1.06 8761600.0 -388505.0 -0.326685949355959 -1.2372 -0.9213 3001248 BCB02_000236 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccccc2[N+](=O)[O-])c3cc4ccccc4[nH]3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O15 compound treatment 1.01462E7 439000.0 0.38 1.032828E7 727000.0 0.6 9220240.0 70135.0 0.0589750944211277 0.6003 0.8407 3092865 BCB02_000237 CCC(CC)C(O)C1C=CC2C(N1Nc3ccccc3F)C(=O)N(C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O16 mock treatment 1.04596E7 752000.0 0.65 9730640.0 130000.0 0.11 8943680.0 -206425.0 -0.173578582246828 0.3355 0.4944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O17 mock treatment 1.020376E7 496000.0 0.43 9413600.0 -188000.0 -0.16 9076720.0 -73385.0 -0.0617079532914302 0.1211 0.2641 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O18 mock treatment 1.005204E7 345000.0 0.3 9892600.0 291000.0 0.24 9108840.0 -41265.0 -0.0346988988563176 0.2908 0.7568 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O19 mock treatment 1.027212E7 565000.0 0.49 9519240.0 -81900.0 -0.07 9692240.0 542135.0 0.455870290354289 0.5045 0.7533 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O20 mock treatment 9866480.0 159000.0 0.14 9101600.0 -500000.0 -0.41 8974000.0 -176105.0 -0.148083111186037 -0.2457 -0.5333 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O21 mock treatment 9351960.0 -356000.0 -0.31 9386480.0 -215000.0 -0.18 9336160.0 186055.0 0.156449863727424 -0.1891 -0.4887 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O22 mock treatment 9882720.0 175000.0 0.15 8737240.0 -864000.0 -0.72 8983640.0 -166465.0 -0.139977031336893 -0.4075 -0.5466 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O23 mock treatment 8794320.0 -913000.0 -0.79 9389400.0 -212000.0 -0.18 8563440.0 -586665.0 -0.493314661275695 -0.84 -0.8894 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 O24 mock treatment 8167400.0 -1540000.0 -1.33 8043960.0 -1560000.0 -1.29 7793440.0 -1356665.0 -1.14079199362428 -2.1697 -0.998 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P01 compound treatment 8001320.0 -1710000.0 -1.47 8072120.0 -1530000.0 -1.27 7288240.0 -1861865.0 -1.56560439401715 -2.484 -0.9963 3001249 BCB02_000238 CC(C)OC(=O)CC(=O)CC(O)c1cccc(c1)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P02 compound treatment 9153200.0 -554000.0 -0.48 8946520.0 -655000.0 -0.54 8431480.0 -718625.0 -0.6042771402065 -0.9378 -0.9954 3092866 BCB02_000239 CC[C@@H]1[C@H]2[C@@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)CC5C2C(=O)N(CC)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P03 compound treatment 9033920.0 -674000.0 -0.58 8844040.0 -757000.0 -0.63 7220640.0 -1929465.0 -1.62244785851944 -1.634 -0.8911 3001250 BCB02_000240 CC(C)OC(=O)CC(=O)CC(O)c1cccc(C#N)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P04 compound treatment 7656280.0 -2050000.0 -1.77 7417720.0 -2180000.0 -1.81 6863560.0 -2286545.0 -1.92270916479871 -3.1751 -0.9994 3092867 BCB02_000241 CCOC(=O)C1=CC[C@H](N([C@H]1CC)S(=O)(=O)c2ccc(C)cc2)c3ccc(OC)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P05 compound treatment 9364280.0 -343000.0 -0.3 9012120.0 -589000.0 -0.49 1.003028E7 880175.0 0.740121248051844 -0.0253 -0.0271 3001251 BCB02_000242 CC(C)OC(=O)CC(=O)CC(O)c1ccc(C#N)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P06 compound treatment 7831800.0 -1880000.0 -1.61 9504560.0 -96500.0 -0.08 8016600.0 -1133505.0 -0.953141290394529 -1.5286 -0.8146 3092868 BCB02_000243 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P07 compound treatment 1.28316E7 3120000.0 2.69 1.11872E7 1590000.0 1.32 8519880.0 -630225.0 -0.529943378934272 2.006 0.6599 3001252 BCB02_000244 COC(=O)C1=CCC(CC1)(C=C)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P08 compound treatment 8701480.0 -1010000.0 -0.87 9455200.0 -146000.0 -0.12 6847800.0 -2302305.0 -1.93596142812054 -1.6875 -0.7944 3092869 BCB02_000245 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccc(Cl)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P09 compound treatment 9045880.0 -662000.0 -0.57 8252760.0 -1350000.0 -1.12 8239400.0 -910705.0 -0.765793303839639 -1.4167 -0.9635 3001253 BCB02_000246 COC(=O)/C=C(/CC(O)c1cccc(Cl)c1)\OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P10 compound treatment 8370680.0 -1340000.0 -1.15 7643520.0 -1960000.0 -1.62 6960200.0 -2189905.0 -1.8414465551907 -2.665 -0.9829 3092870 BCB02_000247 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P11 compound treatment 9975880.0 268000.0 0.23 9319400.0 -282000.0 -0.23 8290640.0 -859465.0 -0.722706630450624 -0.4188 -0.5276 3001254 BCB02_000248 OC(C/C(=C/C(=O)OCCF)/OCCF)c1cccc(Cl)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P12 compound treatment 1.122152E7 1510000.0 1.3 8534840.0 -1070000.0 -0.88 8129320.0 -1020785.0 -0.858357335975915 -0.254 -0.1416 3092871 BCB02_000249 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(Br)c2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OCC=C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P13 compound treatment 9431280.0 -276000.0 -0.24 8505760.0 -1100000.0 -0.91 7551920.0 -1598185.0 -1.34388124727212 -1.4378 -0.8769 3001255 BCB02_000250 CCO/C(=C\C(=O)OC)/CC(O)c1cccc(Cl)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P14 compound treatment 9302800.0 -405000.0 -0.35 8925120.0 -676000.0 -0.56 8137400.0 -1012705.0 -0.851563028384517 -1.0165 -0.9434 3092774 BCB02_000251 CC[C@@H]1C(Sc2ccccc2)C([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P15 compound treatment 9789480.0 82000.0 0.07 9340840.0 -260000.0 -0.22 8839120.0 -310985.0 -0.261500958701852 -0.2349 -0.6782 3092872 BCB02_000252 FCCOC(=O)C1=CCC(O1)c2cccc(Cl)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P16 mock treatment 9289360.0 -418000.0 -0.36 9112680.0 -488000.0 -0.41 8074080.0 -1076025.0 -0.904807527974533 -0.9641 -0.9141 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P17 mock treatment 9373400.0 -334000.0 -0.29 8746240.0 -855000.0 -0.71 8251880.0 -898225.0 -0.755299125777677 -1.0115 -0.9408 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P18 mock treatment 9580200.0 -127000.0 -0.11 9277240.0 -324000.0 -0.27 8090200.0 -1059905.0 -0.891252547977833 -0.7329 -0.782 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P19 mock treatment 9052440.0 -655000.0 -0.56 8531320.0 -1070000.0 -0.89 7563320.0 -1586785.0 -1.33429521923475 -1.6082 -0.9467 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P20 mock treatment 8740560.0 -967000.0 -0.83 8938320.0 -663000.0 -0.55 8194720.0 -955385.0 -0.803363806708905 -1.2617 -0.9852 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P21 mock treatment 8528920.0 -1180000.0 -1.01 8628680.0 -972000.0 -0.81 7485560.0 -1664545.0 -1.39968202100543 -1.8595 -0.9748 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P22 mock treatment 8270880.0 -1440000.0 -1.24 8667280.0 -934000.0 -0.77 8255840.0 -894265.0 -0.75196924235417 -1.5953 -0.9719 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P23 mock treatment 7955840.0 -1750000.0 -1.51 8427920.0 -1170000.0 -0.97 7291600.0 -1858505.0 -1.56277903838508 -2.3346 -0.9811 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2088 P24 mock treatment 7424560.0 -2280000.0 -1.96 7620400.0 -1980000.0 -1.64 6858200.0 -2291905.0 -1.92721627973558 -3.1957 -0.997 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A01 compound treatment 3020120.0 -5950000.0 -5.12 3063400.0 -5690000.0 -4.72 3198320.0 -6581626.66666667 -5.53435594369828 -8.876 -0.9979 3186889 PK04_093001 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A02 compound treatment 3006680.0 -5960000.0 -5.13 4743440.0 -4010000.0 -3.33 3149320.0 -6630626.66666667 -5.57555904666591 -8.1018 -0.9791 3067555 PK04_093002 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A03 compound treatment 7070880.0 -1900000.0 -1.63 7557680.0 -1200000.0 -0.99 7879520.0 -1900426.66666667 -1.59803011487981 -2.438 -0.9789 3186890 PK04_093003 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A04 compound treatment 7808680.0 -1160000.0 -1.0 7064120.0 -1690000.0 -1.4 8375960.0 -1403986.66666667 -1.18058382024198 -2.0668 -0.9905 3186891 PK04_093004 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A05 compound treatment 7629600.0 -1340000.0 -1.15 7273800.0 -1480000.0 -1.23 6885840.0 -2894106.66666667 -2.43359540787741 -2.7788 -0.9391 3067558 PK04_093005 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A06 compound treatment 7880200.0 -1090000.0 -0.94 7472440.0 -1280000.0 -1.06 8060360.0 -1719586.66666667 -1.44596543853966 -1.9889 -0.9826 3186892 PK04_093006 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A07 compound treatment 4267960.0 -4700000.0 -4.04 5006360.0 -3750000.0 -3.11 4603920.0 -5176026.66666667 -4.35241550428376 -6.643 -0.9906 3067559 PK04_093007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A08 compound treatment 7834040.0 -1130000.0 -0.97 8172200.0 -582000.0 -0.48 8529640.0 -1250306.66666667 -1.05135743526103 -1.4489 -0.9576 3186893 PK04_093008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A09 compound treatment 7848840.0 -1120000.0 -0.96 7944320.0 -810000.0 -0.67 8775240.0 -1004706.66666667 -0.844837392631401 -1.4314 -0.9898 3186894 PK04_093009 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A10 compound treatment 6055760.0 -2910000.0 -2.51 6674720.0 -2080000.0 -1.73 6798440.0 -2981506.66666667 -2.50708828949723 -3.8902 -0.9868 3067560 PK04_093010 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A11 compound treatment 7247440.0 -1720000.0 -1.48 7695120.0 -1060000.0 -0.88 7657200.0 -2122746.66666667 -1.78497447920155 -2.3924 -0.9648 3186895 PK04_093011 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A12 compound treatment 6706880.0 -2260000.0 -1.95 7081360.0 -1670000.0 -1.39 7109520.0 -2670426.66666667 -2.2455074472284 -3.2209 -0.9822 3186896 PK04_093012 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A13 mock treatment 8375400.0 -591000.0 -0.51 7831880.0 -923000.0 -0.77 8838680.0 -941266.66666667 -0.791491987483096 -1.1928 -0.9833 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A14 mock treatment 8471880.0 -495000.0 -0.43 8097080.0 -658000.0 -0.55 8869640.0 -910306.66666667 -0.765458353444769 -1.0029 -0.9718 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A15 compound treatment 4164800.0 -4800000.0 -4.13 4375880.0 -4380000.0 -3.63 3964720.0 -5815226.66666667 -4.88990577809833 -7.3065 -0.9926 3067562 PK04_093013 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A16 compound treatment 5665000.0 -3300000.0 -2.84 6135520.0 -2620000.0 -2.17 5951600.0 -3828346.66666667 -3.2191788143363 -4.7537 -0.9878 3186897 PK04_093014 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A17 compound treatment 8833360.0 -134000.0 -0.11 8112320.0 -642000.0 -0.53 8386360.0 -1393586.66666667 -1.17183867185701 -1.0506 -0.8129 3067564 PK04_093015 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A18 compound treatment 5516280.0 -3450000.0 -2.97 5302640.0 -3450000.0 -2.86 6247960.0 -3531986.66666667 -2.96997572055081 -5.0826 -0.9999 3186898 PK04_093016 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A19 compound treatment 3897000.0 -5070000.0 -4.36 4833760.0 -3920000.0 -3.25 3911800.0 -5868146.66666667 -4.93440512930338 -7.246 -0.9864 3186899 PK04_093017 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A20 compound treatment 3773120.0 -5190000.0 -4.47 4105880.0 -4650000.0 -3.86 3361960.0 -6417986.66666667 -5.39675439737942 -7.9231 -0.9906 3067604 PK04_093018 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A21 compound treatment 5789160.0 -3180000.0 -2.73 5716040.0 -3040000.0 -2.52 6191800.0 -3588146.66666667 -3.01719952182963 -4.7763 -0.9973 3186900 PK04_093019 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A22 compound treatment 7055920.0 -1910000.0 -1.64 6786160.0 -1970000.0 -1.63 7643080.0 -2136866.66666667 -1.79684769989345 -2.9298 -0.999 3067607 PK04_093020 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A23 compound treatment 7871040.0 -1100000.0 -0.94 7623240.0 -1130000.0 -0.94 8308040.0 -1471906.66666667 -1.23769636623304 -1.801 -0.9911 3186901 PK04_093021 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 A24 compound treatment 5367480.0 -3600000.0 -3.1 6789240.0 -1970000.0 -1.63 5835400.0 -3944546.66666667 -3.31688902994527 -4.6449 -0.9632 3186902 PK04_093022 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B01 compound treatment 6276320.0 -2690000.0 -2.32 6352600.0 -2400000.0 -1.99 6931040.0 -2848906.66666667 -2.39558764758889 -3.8705 -0.997 3067612 PK04_093023 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B02 compound treatment 8251440.0 -715000.0 -0.62 7818600.0 -936000.0 -0.78 8766520.0 -1013426.66666667 -0.852169863200335 -1.2958 -0.9914 3186903 PK04_093024 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B03 compound treatment 8029320.0 -938000.0 -0.81 7267560.0 -1490000.0 -1.23 9668880.0 -111066.66666667 -0.0933937000599809 -1.232 -0.8341 3067614 PK04_093025 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B04 compound treatment 3442120.0 -5520000.0 -4.75 3011400.0 -5740000.0 -4.76 3600360.0 -6179586.66666667 -5.19628868824707 -8.496 -0.9991 3186904 PK04_093026 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B05 compound treatment 6664280.0 -2300000.0 -1.98 5634160.0 -3120000.0 -2.59 8019160.0 -1760786.66666667 -1.48060968021857 -3.4935 -0.9757 3186905 PK04_093027 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B06 compound treatment 8884280.0 -82600.0 -0.07 8619960.0 -135000.0 -0.11 9859760.0 79813.3333333302 0.0671134079902771 -0.0668 -0.45 3068180 PK04_093028 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B07 compound treatment 7515920.0 -1450000.0 -1.25 7472800.0 -1280000.0 -1.06 8981360.0 -798586.66666667 -0.671515278678555 -1.7226 -0.972 3186906 PK04_093029 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B08 compound treatment 4699720.0 -4270000.0 -3.67 3298840.0 -5460000.0 -4.53 5008760.0 -4771186.66666667 -4.01199378580584 -7.0497 -0.9963 3186992 PK04_093030 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B09 compound treatment 6641760.0 -2330000.0 -2.0 5730120.0 -3020000.0 -2.51 7974040.0 -1805906.66666667 -1.51855017013489 -3.4807 -0.9803 3068181 PK04_093031 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B10 compound treatment 7325720.0 -1640000.0 -1.41 6946920.0 -1810000.0 -1.5 7676840.0 -2103106.66666667 -1.7684596028284 -2.7023 -0.9953 3186993 PK04_093032 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B11 compound treatment 3747080.0 -5220000.0 -4.49 3908440.0 -4850000.0 -4.02 4037520.0 -5742426.66666667 -4.82868973940355 -7.7026 -0.9972 3068182 PK04_093033 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B12 compound treatment 7972360.0 -995000.0 -0.86 8144080.0 -611000.0 -0.51 9752880.0 -27066.6666666698 -0.0227598092583167 -0.7998 -0.8039 3186994 PK04_093034 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B13 mock treatment 9311520.0 345000.0 0.3 9196720.0 442000.0 0.37 9393280.0 -386666.66666667 -0.325140132261632 0.1953 0.3408 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B14 mock treatment 9025120.0 58200.0 0.05 8988760.0 234000.0 0.19 9915160.0 135213.33333333 0.11369814073328 0.2067 0.8966 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B15 compound treatment 8517000.0 -450000.0 -0.39 8529560.0 -225000.0 -0.19 9781440.0 1493.33333333023 0.0012557136142492 -0.3306 -0.7691 3068183 PK04_093035 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B16 compound treatment 7381120.0 -1590000.0 -1.36 7939280.0 -815000.0 -0.68 8050440.0 -1729506.66666667 -1.45430696469148 -2.0181 -0.9583 3186995 PK04_093036 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B17 compound treatment 2742200.0 -6220000.0 -5.36 5631240.0 -3120000.0 -2.59 2976960.0 -6802986.66666667 -5.72049306355371 -7.8917 -0.956 3186996 PK04_093037 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B18 compound treatment 9085040.0 118000.0 0.1 8588160.0 -167000.0 -0.14 1.002372E7 243773.33333333 0.204984035797907 0.0973 0.3641 3068184 PK04_093038 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B19 compound treatment 4753400.0 -4210000.0 -3.63 7453240.0 -1300000.0 -1.08 5807600.0 -3972346.66666667 -3.34026548428201 -4.6455 -0.9204 3186997 PK04_093039 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B20 compound treatment 7326600.0 -1640000.0 -1.41 7715360.0 -1040000.0 -0.86 8098240.0 -1681706.66666667 -1.41411291730672 -2.1293 -0.9784 3186998 PK04_093040 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B21 compound treatment 6732040.0 -2230000.0 -1.92 7760480.0 -994000.0 -0.82 8880280.0 -899666.66666667 -0.756511393943224 -2.0234 -0.9093 3068185 PK04_093041 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B22 compound treatment 8549640.0 -417000.0 -0.36 8160840.0 -594000.0 -0.49 9684200.0 -95746.6666666698 -0.0805114237852012 -0.5382 -0.8753 3186999 PK04_093042 CN(C)C(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B23 compound treatment 8497360.0 -470000.0 -0.4 8186000.0 -569000.0 -0.47 9111520.0 -668426.66666667 -0.562066383122071 -0.8302 -0.991 3068186 PK04_093043 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 B24 compound treatment 7027360.0 -1940000.0 -1.67 6998640.0 -1760000.0 -1.46 7739160.0 -2040786.66666667 -1.71605598289079 -2.7955 -0.9976 3187000 PK04_093044 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C01 compound treatment 3907280.0 -5060000.0 -4.35 4302520.0 -4450000.0 -3.69 4940920.0 -4839026.66666667 -4.0690390614247 -6.9957 -0.9978 3187001 PK04_093045 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C02 compound treatment 7460920.0 -1510000.0 -1.3 7887160.0 -868000.0 -0.72 8866320.0 -913626.66666667 -0.768250073890739 -1.6073 -0.9626 3068187 PK04_093046 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C03 compound treatment 8423680.0 -543000.0 -0.47 7743840.0 -1010000.0 -0.84 9032600.0 -747346.66666667 -0.62842860528954 -1.1169 -0.9733 3187002 PK04_093047 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C04 compound treatment 8977280.0 10400.0 0.01 8747480.0 -7190.0 -0.01 9554840.0 -225106.66666667 -0.189287615619764 -0.1076 -0.5673 3068188 PK04_093048 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C05 compound treatment 9020920.0 54000.0 0.05 9016760.0 262000.0 0.22 9318360.0 -461586.66666667 -0.388138835819497 -0.0717 -0.1603 3187003 PK04_093049 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C06 compound treatment 9038600.0 71700.0 0.06 8027040.0 -728000.0 -0.6 9866080.0 86133.3333333302 0.07242776739345 -0.271 -0.4436 3187004 PK04_093050 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C07 compound treatment 8906440.0 -60400.0 -0.05 8208040.0 -547000.0 -0.45 9430080.0 -349866.66666667 -0.294195761053284 -0.4617 -0.8502 3068189 PK04_093051 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C08 compound treatment 8933000.0 -33900.0 -0.03 8346960.0 -408000.0 -0.34 9943040.0 163093.33333333 0.137141865442213 -0.1329 -0.3631 3187005 PK04_093052 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C09 compound treatment 8591640.0 -375000.0 -0.32 8793440.0 38800.0 0.03 9772480.0 -7466.66666666977 -0.00627856807126166 -0.1715 -0.5284 3187006 PK04_093053 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C10 compound treatment 4473040.0 -4490000.0 -3.87 5338040.0 -3420000.0 -2.83 4737520.0 -5042426.66666667 -4.24007398272302 -6.3174 -0.987 3068190 PK04_093054 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C11 mock treatment 9119080.0 152000.0 0.13 9014120.0 259000.0 0.22 1.01216E7 341653.33333333 0.287289336174893 0.3658 0.9572 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C12 mock treatment 9171000.0 204000.0 0.18 9286960.0 532000.0 0.44 1.015024E7 370293.33333333 0.311372129419651 0.5361 0.9436 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C13 compound treatment 4257840.0 -4710000.0 -4.05 5556280.0 -3200000.0 -2.65 5199760.0 -4580186.66666667 -3.85138577219729 -6.0954 -0.9849 3187007 PK04_093055 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C14 compound treatment 7668960.0 -1300000.0 -1.12 8313520.0 -441000.0 -0.37 8555440.0 -1224506.66666667 -1.02966274022909 -1.4507 -0.9283 3068191 PK04_093056 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C15 mock treatment 9203960.0 237000.0 0.2 8695240.0 -59400.0 -0.05 9988560.0 208613.33333333 0.175418707219496 0.1906 0.6968 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C16 mock treatment 8862040.0 -105000.0 -0.09 8496560.0 -258000.0 -0.21 9408520.0 -371426.66666667 -0.312325126359044 -0.356 -0.9146 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C17 compound treatment 3550600.0 -5420000.0 -4.66 4477480.0 -4280000.0 -3.55 3966840.0 -5813106.66666667 -4.88812311323524 -7.562 -0.9911 3187008 PK04_093057 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C18 compound treatment 8022960.0 -944000.0 -0.81 7971360.0 -783000.0 -0.65 8772240.0 -1007706.66666667 -0.847360031588603 -1.3334 -0.9938 3068193 PK04_093058 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C19 compound treatment 6245240.0 -2720000.0 -2.34 7266840.0 -1490000.0 -1.23 6992320.0 -2787626.66666667 -2.34405854248977 -3.4183 -0.9667 3187009 PK04_093059 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C20 compound treatment 6575600.0 -2390000.0 -2.06 7121440.0 -1630000.0 -1.35 8066760.0 -1713186.66666667 -1.44058380876429 -2.8022 -0.9818 3187010 PK04_093060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C21 compound treatment 7894840.0 -1070000.0 -0.92 7706120.0 -1050000.0 -0.87 8660760.0 -1119186.66666667 -0.94110129523824 -1.5782 -0.9995 3068197 PK04_093061 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C22 compound treatment 8394400.0 -572000.0 -0.49 7860840.0 -894000.0 -0.74 8822400.0 -957546.66666667 -0.805181508224181 -1.1774 -0.9809 3187011 PK04_093062 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C23 compound treatment 8116920.0 -850000.0 -0.73 7949480.0 -805000.0 -0.67 9370240.0 -409706.66666667 -0.344513999452945 -1.0069 -0.96 3068199 PK04_093063 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 C24 compound treatment 7508080.0 -1460000.0 -1.26 7614680.0 -1140000.0 -0.95 7793600.0 -1986346.66666667 -1.67027849461409 -2.2352 -0.9746 3187012 PK04_093064 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCCCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D01 compound treatment 8198080.0 -769000.0 -0.66 8592960.0 -162000.0 -0.13 9328040.0 -451906.66666667 -0.379999120784258 -0.6789 -0.8763 3187091 PK04_093065 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D02 compound treatment 8696760.0 -270000.0 -0.23 8687600.0 -67100.0 -0.06 9192400.0 -587546.66666667 -0.494056036835897 -0.4516 -0.8228 3068202 PK04_093066 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D03 compound treatment 8703880.0 -263000.0 -0.23 9190880.0 436000.0 0.36 1.017716E7 397213.33333333 0.33400860966228 0.2711 0.5002 3187092 PK04_093067 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D04 compound treatment 4060960.0 -4910000.0 -4.22 4140360.0 -4610000.0 -3.83 5178880.0 -4601066.66666667 -3.86894333933942 -6.8815 -0.999 3187093 PK04_093068 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D05 compound treatment 6201960.0 -2760000.0 -2.38 4437120.0 -4320000.0 -3.58 5654480.0 -4125466.66666667 -3.46902097665761 -5.4446 -0.9855 3068220 PK04_093069 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D06 compound treatment 6254680.0 -2710000.0 -2.33 4812400.0 -3940000.0 -3.27 4590360.0 -5189586.66666667 -4.36381783237032 -5.7553 -0.9702 3187094 PK04_093070 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D07 compound treatment 8718960.0 -248000.0 -0.21 8452360.0 -302000.0 -0.25 1.0199E7 419053.33333333 0.352373421270713 -0.0645 -0.1338 3068223 PK04_093071 COC(=O)[C@H]1COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D08 compound treatment 4112440.0 -4850000.0 -4.18 3530320.0 -5220000.0 -4.33 4331080.0 -5448866.66666667 -4.58184110864479 -7.5597 -0.9993 3187095 PK04_093072 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D09 compound treatment 3376680.0 -5590000.0 -4.81 3092920.0 -5660000.0 -4.7 3501480.0 -6278466.66666667 -5.27943486827646 -8.5375 -0.9987 3068225 PK04_093073 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D10 compound treatment 9415760.0 449000.0 0.39 8643520.0 -111000.0 -0.09 1.054204E7 762093.33333333 0.640828777230271 0.5398 0.716 3187096 PK04_093074 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D11 mock treatment 9324240.0 357000.0 0.31 9364280.0 610000.0 0.51 1.083708E7 1057133.33333333 0.888921909874593 0.9828 0.9202 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D12 mock treatment 9266520.0 300000.0 0.26 8927480.0 173000.0 0.14 1.100904E7 1229093.33333333 1.03351957490143 0.8284 0.7707 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D13 compound treatment 5336200.0 -3630000.0 -3.12 6520320.0 -2230000.0 -1.85 5367920.0 -4412026.66666667 -3.70998344984958 -5.0162 -0.966 3187097 PK04_093075 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D14 compound treatment 7844440.0 -1120000.0 -0.97 7760240.0 -994000.0 -0.82 8994800.0 -785146.66666667 -0.660213856150289 -1.4152 -0.9885 3068228 PK04_093076 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D15 mock treatment 9062560.0 95700.0 0.08 8826160.0 71500.0 0.06 1.04464E7 666453.33333333 0.560407047274662 0.4053 0.7117 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D16 mock treatment 8920600.0 -46300.0 -0.04 8474760.0 -280000.0 -0.23 1.006936E7 289413.33333333 0.243361783133478 -0.0166 -0.0489 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D17 compound treatment 8108800.0 -858000.0 -0.74 7636760.0 -1120000.0 -0.93 9312920.0 -467026.66666667 -0.392713221128557 -1.1885 -0.9517 3187098 PK04_093077 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D18 compound treatment 8503640.0 -463000.0 -0.4 8472240.0 -282000.0 -0.23 1.005648E7 276533.33333333 0.232531253210556 -0.2312 -0.4467 3187099 PK04_093078 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D19 compound treatment 8481320.0 -486000.0 -0.42 8359560.0 -395000.0 -0.33 9951880.0 171933.33333333 0.144575241569436 -0.347 -0.6305 3068229 PK04_093079 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D20 compound treatment 8141920.0 -825000.0 -0.71 8271520.0 -483000.0 -0.4 9758840.0 -21106.6666666698 -0.0177481665300081 -0.6516 -0.799 3187100 PK04_093080 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D21 compound treatment 6197840.0 -2770000.0 -2.38 6129040.0 -2630000.0 -2.18 6838640.0 -2941306.66666667 -2.47328492747072 -4.0614 -0.9986 3068232 PK04_093081 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D22 compound treatment 8985480.0 18600.0 0.02 7906040.0 -849000.0 -0.7 9683960.0 -95986.6666666698 -0.0807132349017774 -0.4438 -0.6262 3187101 PK04_093082 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D23 compound treatment 6974720.0 -1990000.0 -1.71 7055800.0 -1700000.0 -1.41 7567320.0 -2212626.66666667 -1.86055274235933 -2.8778 -0.9937 3187102 PK04_093083 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 D24 compound treatment 8311800.0 -655000.0 -0.56 7327040.0 -1430000.0 -1.18 8592680.0 -1187266.66666667 -0.998348381973684 -1.5857 -0.962 3068234 PK04_093084 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E01 mock treatment 8187920.0 -779000.0 -0.67 7557480.0 -1200000.0 -0.99 9052120.0 -727826.66666667 -0.612014634474677 -1.3138 -0.9764 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E02 mock treatment 8585600.0 -381000.0 -0.33 8435720.0 -319000.0 -0.26 9677600.0 -102346.66666667 -0.0860612294910463 -0.3919 -0.9109 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E03 compound treatment 7586480.0 -1380000.0 -1.19 7795640.0 -959000.0 -0.8 9264560.0 -515386.66666667 -0.433378161118658 -1.3954 -0.934 3187103 PK04_093085 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E04 compound treatment 5859600.0 -3110000.0 -2.67 5444880.0 -3310000.0 -2.75 6608960.0 -3170986.66666667 -2.66641816603413 -4.6687 -0.9999 3187104 PK04_093086 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E05 compound treatment 8642600.0 -324000.0 -0.28 9011040.0 256000.0 0.21 1.04934E7 713453.33333333 0.599928390937498 0.308 0.4432 3068237 PK04_093087 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E06 compound treatment 9604600.0 638000.0 0.55 8719400.0 -35300.0 -0.03 9795440.0 15493.3333333302 0.0130280287478599 0.3075 0.5593 3187105 PK04_093088 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E07 compound treatment 3645720.0 -5320000.0 -4.58 1404600.0 -7350000.0 -6.1 2391120.0 -7388826.66666667 -6.21311399911617 -9.7515 -0.9914 3068240 PK04_093089 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E08 compound treatment 4979120.0 -3990000.0 -3.43 3724240.0 -5030000.0 -4.17 4677200.0 -5102746.66666667 -4.29079584335583 -6.8681 -0.9954 3187106 PK04_093090 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E09 mock treatment 8958160.0 -8720.0 -0.01 9334400.0 580000.0 0.48 1.071492E7 934973.33333333 0.786200051537315 0.7272 0.7891 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E10 mock treatment 9811160.0 844000.0 0.73 9357040.0 602000.0 0.5 1.089E7 1110053.33333333 0.933421261079641 1.2469 0.971 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E11 compound treatment 8092440.0 -874000.0 -0.75 7917120.0 -838000.0 -0.69 9407680.0 -372266.66666667 -0.313031465267061 -1.0164 -0.949 3068242 PK04_093091 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E12 compound treatment 8031320.0 -936000.0 -0.81 7747400.0 -1010000.0 -0.84 8668440.0 -1111506.66666667 -0.934643339507802 -1.4869 -0.9979 3187107 PK04_093092 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E13 compound treatment 4693800.0 -4270000.0 -3.68 3575080.0 -5180000.0 -4.3 5706160.0 -4073786.66666667 -3.42556431622154 -6.5818 -0.9954 3068264 PK04_093093 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E14 compound treatment 6086680.0 -2880000.0 -2.48 5216880.0 -3540000.0 -2.93 7953000.0 -1826946.66666667 -1.53624227802141 -4.0125 -0.9698 3187108 PK04_093094 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E15 compound treatment 4518280.0 -4450000.0 -3.83 4163080.0 -4590000.0 -3.81 5317080.0 -4462866.66666667 -3.75273377137763 -6.5763 -1.0 3187109 PK04_093095 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E16 compound treatment 7813280.0 -1150000.0 -0.99 7276720.0 -1480000.0 -1.23 9283240.0 -496706.66666667 -0.417670529211812 -1.5222 -0.9327 3068267 PK04_093096 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E17 mock treatment 9599800.0 633000.0 0.54 8775000.0 20300.0 0.02 9839560.0 59613.3333333302 0.0501276390117817 0.3532 0.6453 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E18 mock treatment 8954560.0 -12300.0 -0.01 9325920.0 571000.0 0.47 1.017572E7 395773.33333333 0.332797742962823 0.4596 0.7936 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E19 compound treatment 8594720.0 -372000.0 -0.32 9141720.0 387000.0 0.32 1.0441E7 661053.33333333 0.555866297151698 0.3214 0.448 3187110 PK04_093097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E20 compound treatment 7738680.0 -1230000.0 -1.06 8193600.0 -561000.0 -0.47 8703080.0 -1076866.66666667 -0.90551526834864 -1.4018 -0.9552 3187111 PK04_093098 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E21 compound treatment 8347640.0 -619000.0 -0.53 8142840.0 -612000.0 -0.51 9224240.0 -555706.66666667 -0.467282428703457 -0.8705 -0.9986 3068269 PK04_093099 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E22 compound treatment 7421640.0 -1550000.0 -1.33 6951480.0 -1800000.0 -1.5 7782640.0 -1997306.66666667 -1.6794945356044 -2.6011 -0.9955 3187184 PK04_093100 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E23 compound treatment 8073920.0 -893000.0 -0.77 7734320.0 -1020000.0 -0.85 8559000.0 -1220946.66666667 -1.02666920866654 -1.5251 -0.9925 3068272 PK04_093101 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 E24 compound treatment 4126680.0 -4840000.0 -4.17 4288400.0 -4470000.0 -3.71 4491880.0 -5288066.66666667 -4.44662766053874 -7.1114 -0.9972 3187185 PK04_093102 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F01 mock treatment 8435480.0 -531000.0 -0.46 7691560.0 -1060000.0 -0.88 9270360.0 -509586.66666667 -0.428501059134734 -1.0206 -0.9433 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F02 mock treatment 8675560.0 -291000.0 -0.25 8617720.0 -137000.0 -0.11 9672080.0 -107866.66666667 -0.0907028851722985 -0.2627 -0.9065 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F03 compound treatment 5849480.0 -3120000.0 -2.68 4772840.0 -3980000.0 -3.3 5640160.0 -4139786.66666667 -3.48106237327999 -5.4659 -0.9942 3068274 PK04_093103 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F04 compound treatment 5853280.0 -3110000.0 -2.68 4972720.0 -3780000.0 -3.14 6068720.0 -3711226.66666667 -3.12069498944712 -5.1602 -0.9975 3187186 PK04_093104 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F05 compound treatment 3130520.0 -5840000.0 -5.02 3393200.0 -5360000.0 -4.45 3760480.0 -6019466.66666667 -5.06164703830466 -8.3903 -0.9983 3068276 PK04_093105 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F06 compound treatment 8470520.0 -496000.0 -0.43 7007040.0 -1750000.0 -1.45 8867800.0 -912146.66666667 -0.767005572005186 -1.5265 -0.9006 3187187 PK04_093106 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F07 compound treatment 7494040.0 -1470000.0 -1.27 6157920.0 -2600000.0 -2.15 7636120.0 -2143826.66666667 -1.80270022227416 -3.0164 -0.9788 3187188 PK04_093107 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F08 compound treatment 7905800.0 -1060000.0 -0.91 5731800.0 -3020000.0 -2.51 8229360.0 -1550586.66666667 -1.30385677728393 -2.7278 -0.9184 3068278 PK04_093108 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F09 mock treatment 9044600.0 77700.0 0.07 8936440.0 182000.0 0.15 1.085232E7 1072373.33333333 0.901736915777181 0.6463 0.705 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F10 mock treatment 9634520.0 668000.0 0.57 8570080.0 -185000.0 -0.15 1.000112E7 221173.33333333 0.185980155653649 0.3507 0.5629 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F11 compound treatment 7436400.0 -1530000.0 -1.32 5846000.0 -2910000.0 -2.41 8832120.0 -947826.66666667 -0.797008158002845 -2.6137 -0.9132 3187189 PK04_093109 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F12 compound treatment 9206760.0 240000.0 0.21 9554840.0 800000.0 0.66 1.03504E7 570453.33333333 0.479682600644189 0.7794 0.9228 3068280 PK04_093110 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F13 compound treatment 5197960.0 -3770000.0 -3.24 4826840.0 -3930000.0 -3.26 8459560.0 -1320386.66666667 -1.11028628130127 -4.395 -0.9292 3187190 PK04_093111 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F14 compound treatment 5226440.0 -3740000.0 -3.22 5140480.0 -3610000.0 -3.0 6062320.0 -3717626.66666667 -3.12607661922248 -5.3945 -0.9996 3187191 PK04_093112 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F15 compound treatment 3902000.0 -5060000.0 -4.36 3571280.0 -5180000.0 -4.3 5138760.0 -4641186.66666667 -3.90267943099374 -7.2525 -0.9988 3068282 PK04_093113 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F16 compound treatment 6947360.0 -2020000.0 -1.74 6428040.0 -2330000.0 -1.93 6690600.0 -3089346.66666667 -2.59776875121213 -3.6176 -0.9848 3187192 PK04_093114 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F17 mock treatment 9285720.0 319000.0 0.27 9505560.0 751000.0 0.62 1.018272E7 402773.33333333 0.338683900529628 0.7136 0.9386 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F18 mock treatment 9237000.0 270000.0 0.23 8953800.0 199000.0 0.17 1.0283E7 503053.33333333 0.423007312072377 0.4738 0.9288 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F19 compound treatment 4603120.0 -4360000.0 -3.76 4098920.0 -4660000.0 -3.86 4520520.0 -5259426.66666667 -4.42254486729398 -6.9516 -0.9974 3187193 PK04_093115 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F20 compound treatment 8871160.0 -95700.0 -0.08 8992160.0 237000.0 0.2 9723240.0 -56706.6666666698 -0.0476834821554753 0.0387 0.1767 3068312 PK04_093116 NC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F21 compound treatment 8481960.0 -485000.0 -0.42 7998680.0 -756000.0 -0.63 8620400.0 -1159546.66666667 -0.975039198009135 -1.166 -0.9463 3068314 PK04_093117 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F22 compound treatment 8931880.0 -35000.0 -0.03 8275640.0 -479000.0 -0.4 9689680.0 -90266.6666666698 -0.075903403290045 -0.2906 -0.7164 3187194 PK04_093118 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F23 compound treatment 6341640.0 -2630000.0 -2.26 5563760.0 -3190000.0 -2.65 5969360.0 -3810586.66666667 -3.20424479170966 -4.6827 -0.9899 3187195 PK04_093119 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 F24 compound treatment 8002320.0 -965000.0 -0.83 7637680.0 -1120000.0 -0.93 9095840.0 -684106.66666667 -0.575251376071715 -1.3464 -0.9823 3068317 PK04_093120 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G01 compound treatment 8016480.0 -950000.0 -0.82 7279360.0 -1480000.0 -1.22 8459200.0 -1320746.66666667 -1.11058899797614 -1.82 -0.987 3187196 PK04_093121 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G02 compound treatment 8530960.0 -436000.0 -0.38 8306040.0 -449000.0 -0.37 9331120.0 -448826.66666667 -0.377409211454863 -0.6494 -1.0 3068319 PK04_093122 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCCCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G03 mock treatment 9072040.0 105000.0 0.09 8926320.0 172000.0 0.14 9781160.0 1213.33333333023 0.00102026731157698 0.1351 0.8004 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G04 mock treatment 8838640.0 -128000.0 -0.11 8427760.0 -327000.0 -0.27 9393640.0 -386306.66666667 -0.324837415586768 -0.4078 -0.9326 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G05 compound treatment 9097000.0 130000.0 0.11 8716680.0 -38000.0 -0.03 1.056932E7 789373.33333333 0.663767974147764 0.4297 0.6376 3187197 PK04_093123 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G06 compound treatment 8962280.0 -4600.0 0.0 6364680.0 -2390000.0 -1.98 8378240.0 -1401706.66666667 -1.1786666146345 -1.8275 -0.7923 3187198 PK04_093124 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G07 compound treatment 8874960.0 -91900.0 -0.08 8907640.0 153000.0 0.13 1.047652E7 696573.33333333 0.585734342404973 0.3658 0.605 3068323 PK04_093125 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G08 compound treatment 8420000.0 -547000.0 -0.47 8242120.0 -513000.0 -0.43 9879560.0 99613.3333333302 0.0837628251078123 -0.4689 -0.7328 3187199 PK04_093126 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G09 compound treatment 8817840.0 -149000.0 -0.13 8839040.0 84400.0 0.07 1.003396E7 254013.33333333 0.21359464343849 0.0897 0.3465 3068325 PK04_093127 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G10 compound treatment 8535400.0 -431000.0 -0.37 8082360.0 -672000.0 -0.56 8416320.0 -1363626.66666667 -1.14664591747108 -1.1984 -0.9024 3187200 PK04_093128 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G11 compound treatment 8684600.0 -282000.0 -0.24 8280520.0 -474000.0 -0.39 1.010068E7 320733.33333333 0.269698133846669 -0.2116 -0.3954 3187201 PK04_093129 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G12 compound treatment 4882000.0 -4080000.0 -3.52 4652480.0 -4100000.0 -3.4 8376760.0 -1403186.66666667 -1.17991111652006 -4.6757 -0.929 3068327 PK04_093130 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G13 compound treatment 1346760.0 -7620000.0 -6.56 869000.0 -7890000.0 -6.54 1536760.0 -8243186.66666667 -6.93152793894129 -11.5651 -0.9996 3187202 PK04_093131 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G14 compound treatment 9754320.0 787000.0 0.68 9252920.0 498000.0 0.41 1.020368E7 423733.33333333 0.356308738043948 0.8356 0.9604 3187203 PK04_093132 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G15 compound treatment 9463120.0 496000.0 0.43 8732880.0 -21800.0 -0.02 1.0073E7 293053.33333333 0.246422585068216 0.3784 0.7669 3068330 PK04_093133 COC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G16 compound treatment 6555640.0 -2410000.0 -2.08 6372960.0 -2380000.0 -1.98 7516800.0 -2263146.66666667 -1.90303398239862 -3.4376 -0.9994 3068332 PK04_093134 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G17 compound treatment 8343960.0 -623000.0 -0.54 8672960.0 -81700.0 -0.07 9420960.0 -358986.66666667 -0.301864583483179 -0.5229 -0.8448 3187278 PK04_093135 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G18 compound treatment 7457520.0 -1510000.0 -1.3 7446120.0 -1310000.0 -1.09 8814120.0 -965826.66666667 -0.812143991746059 -1.8456 -0.983 3187279 PK04_093136 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G19 mock treatment 8825520.0 -141000.0 -0.12 8800920.0 46300.0 0.04 1.00724E7 292453.33333333 0.245918057276776 0.0939 0.3389 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G20 mock treatment 8945360.0 -21500.0 -0.02 9427000.0 672000.0 0.56 9376240.0 -403706.66666667 -0.339468721538541 0.1153 0.1766 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G21 compound treatment 8807400.0 -159000.0 -0.14 8819000.0 64300.0 0.05 9494680.0 -285266.66666667 -0.239874935508194 -0.1869 -0.6641 3187280 PK04_093137 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G22 compound treatment 5306440.0 -3660000.0 -3.15 5326240.0 -3430000.0 -2.84 6243320.0 -3536626.66666667 -2.97387740213795 -5.1779 -0.9991 3068361 PK04_093138 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G23 compound treatment 8211680.0 -755000.0 -0.65 7871760.0 -883000.0 -0.73 9155360.0 -624586.66666667 -0.525202219160822 -1.1013 -0.9911 3187281 PK04_093139 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 G24 compound treatment 5999640.0 -2970000.0 -2.55 4622440.0 -4130000.0 -3.43 6186560.0 -3593386.66666667 -3.02160573120821 -5.1981 -0.993 3187282 PK04_093140 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H01 compound treatment 5783400.0 -3180000.0 -2.74 6684080.0 -2070000.0 -1.72 7941080.0 -1838866.66666667 -1.54626556347802 -3.4663 -0.967 3068365 PK04_093141 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H02 compound treatment 6117280.0 -2850000.0 -2.45 5704720.0 -3050000.0 -2.53 6352520.0 -3427426.66666667 -2.88205334409578 -4.5407 -0.9975 3187283 PK04_093142 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H03 mock treatment 9109440.0 143000.0 0.12 8603840.0 -151000.0 -0.13 9605440.0 -174506.66666667 -0.146739105208285 -0.0861 -0.3768 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H04 mock treatment 9559440.0 593000.0 0.51 9309440.0 555000.0 0.46 9438920.0 -341026.66666667 -0.286762384926061 0.3946 0.5301 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H05 compound treatment 6395680.0 -2570000.0 -2.21 6157360.0 -2600000.0 -2.15 7157280.0 -2622666.66666667 -2.20534703502974 -3.7949 -0.9999 3068368 PK04_093143 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H06 compound treatment 9424200.0 457000.0 0.39 8971680.0 217000.0 0.18 1.046408E7 684133.33333333 0.575273799529108 0.6633 0.9214 3187284 PK04_093144 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H07 compound treatment 6094280.0 -2870000.0 -2.47 4489840.0 -4260000.0 -3.54 6003840.0 -3776106.66666667 -3.17525126129488 -5.3033 -0.9897 3187285 PK04_093145 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H08 compound treatment 9161840.0 195000.0 0.17 8925080.0 170000.0 0.14 1.028788E7 507933.33333333 0.427110804776093 0.4251 0.8853 3068370 PK04_093146 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H09 compound treatment 6901680.0 -2070000.0 -1.78 5058680.0 -3700000.0 -3.07 9242640.0 -537306.66666667 -0.451810243099283 -3.0572 -0.8557 3187286 PK04_093147 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H10 compound treatment 6696120.0 -2270000.0 -1.95 6204960.0 -2550000.0 -2.12 9481240.0 -298706.66666667 -0.25117635803646 -2.4945 -0.8629 3187287 PK04_093148 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H11 compound treatment 8180360.0 -787000.0 -0.68 7741480.0 -1010000.0 -0.84 9538440.0 -241506.66666667 -0.203078041919137 -0.9933 -0.9046 3068373 PK04_093149 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H12 compound treatment 8672280.0 -295000.0 -0.25 7989120.0 -766000.0 -0.64 9955280.0 175333.33333333 0.147434232387598 -0.4279 -0.6117 3187288 PK04_093150 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H13 compound treatment 8754360.0 -213000.0 -0.18 6348960.0 -2410000.0 -2.0 9612080.0 -167866.66666667 -0.141155664316344 -1.3393 -0.6666 3187289 PK04_093151 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H14 compound treatment 4234480.0 -4730000.0 -4.07 3914520.0 -4840000.0 -4.02 8251640.0 -1528306.66666667 -1.28512197862844 -5.4117 -0.9232 3068375 PK04_093152 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H15 compound treatment 8398280.0 -569000.0 -0.49 7764120.0 -991000.0 -0.82 9301000.0 -478946.66666667 -0.402736506585174 -0.9895 -0.9535 3187290 PK04_093153 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H16 compound treatment 9093440.0 127000.0 0.11 8811840.0 57200.0 0.05 9943440.0 163493.33333333 0.137478217303173 0.1696 0.9337 3187291 PK04_093154 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H17 compound treatment 8688040.0 -279000.0 -0.24 8295520.0 -459000.0 -0.38 9712600.0 -67346.6666666698 -0.0566304416570195 -0.3912 -0.8621 3068378 PK04_093155 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H18 compound treatment 9182000.0 215000.0 0.19 9387400.0 633000.0 0.52 1.041244E7 632493.33333333 0.531850774279132 0.717 0.9314 3187292 PK04_093156 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H19 mock treatment 9084120.0 117000.0 0.1 8426400.0 -328000.0 -0.27 9727800.0 -52146.6666666698 -0.0438490709405278 -0.1243 -0.4232 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H20 mock treatment 9514080.0 547000.0 0.47 9503080.0 748000.0 0.62 1.051912E7 739173.33333333 0.621555815597246 0.9892 0.9924 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H21 compound treatment 5721040.0 -3250000.0 -2.79 6290640.0 -2460000.0 -2.04 5569760.0 -4210186.66666667 -3.54026030080901 -4.837 -0.9769 3187293 PK04_093157 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H22 compound treatment 7525240.0 -1440000.0 -1.24 8094600.0 -660000.0 -0.55 7448240.0 -2331706.66666667 -1.96068469136722 -2.1645 -0.9079 3068380 PK04_093158 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H23 compound treatment 6940440.0 -2030000.0 -1.74 5199280.0 -3560000.0 -2.95 7300040.0 -2479906.66666667 -2.08530305585301 -3.9137 -0.9757 3068402 PK04_093159 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 H24 compound treatment 4128840.0 -4840000.0 -4.16 2023320.0 -6730000.0 -5.58 4663080.0 -5116866.66666667 -4.30266906404773 -8.1121 -0.9908 3187294 PK04_093160 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I01 compound treatment 7628800.0 -1340000.0 -1.15 7326800.0 -1430000.0 -1.18 8638360.0 -1141586.66666667 -0.959936999452017 -1.903 -0.996 3068406 PK04_093161 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I02 compound treatment 6894280.0 -2070000.0 -1.78 5974600.0 -2780000.0 -2.31 8504640.0 -1275306.66666667 -1.07237942657105 -2.9805 -0.9594 3187295 PK04_093162 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I03 compound treatment 8382840.0 -584000.0 -0.5 7372480.0 -1380000.0 -1.15 9161080.0 -618866.66666667 -0.520392387549089 -1.2527 -0.9239 3068409 PK04_093163 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I04 compound treatment 8725880.0 -241000.0 -0.21 8240440.0 -514000.0 -0.43 9503480.0 -276466.66666667 -0.232475194567068 -0.5003 -0.947 3187296 PK04_093164 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I05 mock treatment 8722200.0 -245000.0 -0.21 8549200.0 -205000.0 -0.17 9522120.0 -257826.66666667 -0.216801197846317 -0.3452 -0.9947 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I06 mock treatment 8846800.0 -120000.0 -0.1 9047480.0 293000.0 0.24 1.042144E7 641493.33333333 0.539418691150739 0.392 0.6528 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I07 compound treatment 7179440.0 -1790000.0 -1.54 4788080.0 -3970000.0 -3.29 6096320.0 -3683626.66666667 -3.09748671104086 -4.5763 -0.9586 3187297 PK04_093165 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I08 compound treatment 8246040.0 -721000.0 -0.62 9019280.0 265000.0 0.22 9844280.0 64333.3333333302 0.0540965909711133 -0.2002 -0.3032 3068413 PK04_093166 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I09 compound treatment 9058880.0 92000.0 0.08 8327120.0 -428000.0 -0.35 1.087104E7 1091093.33333333 0.917478182870123 0.3706 0.3756 3187298 PK04_093167 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I10 compound treatment 8733840.0 -233000.0 -0.2 8476800.0 -278000.0 -0.23 1.059744E7 817493.33333333 0.687413509973274 0.148 0.1967 3187366 PK04_093168 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I11 compound treatment 9667120.0 700000.0 0.6 9169480.0 415000.0 0.34 1.03104E7 530453.33333333 0.446047414548158 0.8041 0.9748 3068416 PK04_093169 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I12 compound treatment 8060000.0 -907000.0 -0.78 7131600.0 -1620000.0 -1.35 9933280.0 153333.33333333 0.128934880034781 -1.1536 -0.7387 3187367 PK04_093170 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I13 compound treatment 9091760.0 125000.0 0.11 9161040.0 406000.0 0.34 1.031936E7 539413.33333333 0.453581696233669 0.5186 0.9014 3068419 PK04_093171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I14 compound treatment 6999480.0 -1970000.0 -1.69 6945320.0 -1810000.0 -1.5 9052600.0 -727346.66666667 -0.611611012241524 -2.1973 -0.9374 3187368 PK04_093172 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I15 compound treatment 8780800.0 -186000.0 -0.16 8728760.0 -25900.0 -0.02 1.003704E7 257093.33333333 0.216184552767885 0.0199 0.0739 3068421 PK04_093173 COC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I16 compound treatment 6357120.0 -2610000.0 -2.25 7711200.0 -1040000.0 -0.87 7077120.0 -2702826.66666667 -2.27275194796619 -3.1087 -0.939 3187369 PK04_093174 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I17 compound treatment 9091640.0 125000.0 0.11 8761360.0 6690.0 0.01 1.008604E7 306093.33333333 0.257387655735522 0.2138 0.7665 3068423 PK04_093175 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I18 compound treatment 8943000.0 -23900.0 -0.02 8981800.0 227000.0 0.19 1.010884E7 328893.33333333 0.27655971181026 0.2566 0.7653 3187370 PK04_093176 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I19 compound treatment 4852400.0 -4110000.0 -3.54 4542800.0 -4210000.0 -3.49 5991000.0 -3788946.66666667 -3.18604815603171 -5.9012 -0.9989 3187371 PK04_093177 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I20 compound treatment 7196000.0 -1770000.0 -1.52 7970880.0 -784000.0 -0.65 7648640.0 -2131306.66666667 -1.7921724090261 -2.29 -0.9382 3068425 PK04_093178 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I21 mock treatment 8961240.0 -5640.0 0.0 8510160.0 -245000.0 -0.2 9199000.0 -580946.66666667 -0.488506231130052 -0.4019 -0.7599 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I22 mock treatment 9060440.0 93600.0 0.08 9091400.0 337000.0 0.28 9394960.0 -384986.66666667 -0.323727454445599 0.0209 0.048 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I23 compound treatment 8169320.0 -798000.0 -0.69 8374880.0 -380000.0 -0.32 9041640.0 -738306.66666667 -0.620827053231837 -0.9366 -0.958 3187372 PK04_093179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 I24 compound treatment 8200880.0 -766000.0 -0.66 7764120.0 -991000.0 -0.82 8203360.0 -1576586.66666667 -1.32571964824635 -1.6204 -0.957 3068456 PK04_093180 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J01 compound treatment 2465520.0 -6500000.0 -5.6 2672600.0 -6080000.0 -5.05 3797240.0 -5982706.66666667 -5.03073630228241 -9.048 -0.9987 3187373 PK04_093181 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J02 compound treatment 3719040.0 -5250000.0 -4.52 4524080.0 -4230000.0 -3.51 5115440.0 -4664506.66666667 -3.92228874448772 -6.8984 -0.9947 3187374 PK04_093182 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J03 compound treatment 7854040.0 -1110000.0 -0.96 5898480.0 -2860000.0 -2.37 8127560.0 -1652386.66666667 -1.38945832589833 -2.7231 -0.9361 3068460 PK04_093183 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J04 compound treatment 9194320.0 227000.0 0.2 7973840.0 -781000.0 -0.65 9723400.0 -56546.6666666698 -0.0475489414110912 -0.2884 -0.4252 3187375 PK04_093184 COCCCNC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J05 mock treatment 9040600.0 73700.0 0.06 8636400.0 -118000.0 -0.1 9394480.0 -385466.66666667 -0.324131076678751 -0.2072 -0.6012 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J06 mock treatment 9298520.0 332000.0 0.29 8598640.0 -156000.0 -0.13 1.03898E7 609853.33333333 0.512813258948779 0.3861 0.6425 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J07 compound treatment 4750400.0 -4220000.0 -3.63 4062720.0 -4690000.0 -3.89 4155160.0 -5624786.66666667 -4.72976865709513 -7.0731 -0.9935 3187376 PK04_093185 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J08 compound treatment 6635680.0 -2330000.0 -2.01 4533960.0 -4220000.0 -3.5 8325160.0 -1454786.66666667 -1.22330050658394 -3.8861 -0.9216 3068463 PK04_093186 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J09 compound treatment 8255280.0 -712000.0 -0.61 7336080.0 -1420000.0 -1.18 8417760.0 -1362186.66666667 -1.14543505077163 -1.6943 -0.9667 3187377 PK04_093187 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J10 compound treatment 8283320.0 -684000.0 -0.59 6825560.0 -1930000.0 -1.6 9566920.0 -213026.66666667 -0.179129789418763 -1.367 -0.7974 3068465 PK04_093188 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J11 compound treatment 6847680.0 -2120000.0 -1.82 4165280.0 -4590000.0 -3.81 9781200.0 1253.33333333023 0.00105390249767302 -3.2505 -0.77 3187378 PK04_093189 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J12 compound treatment 9186840.0 220000.0 0.19 8965280.0 211000.0 0.17 1.040092E7 620973.33333333 0.522163840683475 0.5116 0.8787 3068467 PK04_093190 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J13 compound treatment 6506600.0 -2460000.0 -2.12 6065280.0 -2690000.0 -2.23 9468400.0 -311546.66666667 -0.261973252773286 -2.6618 -0.8623 3187379 PK04_093191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J14 compound treatment 3102920.0 -5860000.0 -5.05 2530480.0 -6220000.0 -5.16 3705280.0 -6074666.66666667 -5.10806359511718 -8.844 -1.0 3187380 PK04_093192 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J15 compound treatment 8464840.0 -502000.0 -0.43 8020240.0 -734000.0 -0.61 9364560.0 -415386.66666667 -0.349290195878582 -0.8029 -0.9737 3068470 PK04_093193 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J16 compound treatment 8872880.0 -94000.0 -0.08 9099840.0 345000.0 0.29 9918720.0 138773.33333333 0.116691672295826 0.186 0.5819 3187381 PK04_093194 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J17 compound treatment 7526920.0 -1440000.0 -1.24 7284320.0 -1470000.0 -1.22 8308960.0 -1470986.66666667 -1.23692275695283 -2.1339 -1.0 3187382 PK04_093195 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J18 compound treatment 3682200.0 -5280000.0 -4.55 3162520.0 -5590000.0 -4.64 4354240.0 -5425706.66666667 -4.56236633589518 -7.9384 -1.0 3068473 PK04_093196 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J19 compound treatment 8665680.0 -301000.0 -0.26 8245000.0 -510000.0 -0.42 9674480.0 -105466.66666667 -0.0886847740065366 -0.445 -0.8832 3187383 PK04_093197 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J20 compound treatment 7918720.0 -1050000.0 -0.9 6752360.0 -2000000.0 -1.66 8100040.0 -1679906.66666667 -1.4125993339324 -2.2954 -0.9727 3068475 PK04_093198 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J21 mock treatment 8260320.0 -707000.0 -0.61 9251560.0 497000.0 0.41 9730480.0 -49466.6666666698 -0.0415955134720938 -0.1371 -0.1863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J22 mock treatment 8830160.0 -137000.0 -0.12 8743080.0 -11600.0 -0.01 9093560.0 -686386.66666667 -0.577168581679189 -0.4067 -0.6904 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J23 compound treatment 7988440.0 -978000.0 -0.84 7749440.0 -1010000.0 -0.83 8578320.0 -1201626.66666667 -1.01042341378216 -1.551 -0.9959 3187384 PK04_093199 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 J24 compound treatment 4984480.0 -3980000.0 -3.43 3964040.0 -4790000.0 -3.97 4362200.0 -5417746.66666667 -4.55567293386207 -6.9035 -0.9934 3068477 PK04_093200 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K01 compound treatment 8250600.0 -716000.0 -0.62 7760240.0 -994000.0 -0.82 7649480.0 -2130466.66666667 -1.79146607011809 -1.8665 -0.9033 3187385 PK04_093201 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K02 compound treatment 5880600.0 -3090000.0 -2.66 5558000.0 -3200000.0 -2.65 6806280.0 -2973666.66666667 -2.50049579302241 -4.5083 -0.9996 3187386 PK04_093202 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K03 compound treatment 8700760.0 -266000.0 -0.23 7559720.0 -1190000.0 -0.99 9529720.0 -250226.66666667 -0.210410512488071 -0.826 -0.7951 3187447 PK04_093203 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K04 compound treatment 7165160.0 -1800000.0 -1.55 4849080.0 -3910000.0 -3.24 6823560.0 -2956386.66666667 -2.48596539262893 -4.2011 -0.9617 3068500 PK04_093204 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K05 compound treatment 5595840.0 -3370000.0 -2.9 4626120.0 -4130000.0 -3.42 5427960.0 -4351986.66666667 -3.65949703551943 -5.7652 -0.9955 3187448 PK04_093205 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K06 compound treatment 2757320.0 -6210000.0 -5.34 2071960.0 -6680000.0 -5.54 2735760.0 -7044186.66666667 -5.92331323571277 -9.706 -0.9991 3187449 PK04_093206 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K07 mock treatment 9767000.0 800000.0 0.69 8188960.0 -566000.0 -0.47 9587120.0 -192826.66666667 -0.162144020440267 0.033 0.0389 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K08 mock treatment 8724960.0 -242000.0 -0.21 8911760.0 157000.0 0.13 1.01384E7 358453.33333333 0.301416114335226 0.1291 0.3319 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K09 compound treatment 8655400.0 -311000.0 -0.27 8540200.0 -214000.0 -0.18 9883280.0 103333.33333333 0.0868908974147431 -0.2073 -0.6221 3068503 PK04_093207 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K10 compound treatment 7623720.0 -1340000.0 -1.16 7694440.0 -1060000.0 -0.88 9987720.0 207773.33333333 0.174712368311479 -1.0743 -0.7343 3187450 PK04_093208 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K11 compound treatment 4445720.0 -4520000.0 -3.89 4177720.0 -4580000.0 -3.8 5444120.0 -4335826.66666667 -3.64590842033664 -6.5436 -0.9996 3068506 PK04_093209 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K12 compound treatment 8101680.0 -865000.0 -0.74 7379120.0 -1380000.0 -1.14 9786800.0 6853.33333333023 0.0057628285511173 -1.0854 -0.7966 3187451 PK04_093210 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K13 compound treatment 9242000.0 275000.0 0.24 9346200.0 592000.0 0.49 1.061104E7 831093.33333333 0.698849473245924 0.8235 0.9293 3187452 PK04_093211 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K14 compound treatment 8408560.0 -558000.0 -0.48 7545200.0 -1210000.0 -1.0 9284840.0 -495106.66666667 -0.416325121767971 -1.0971 -0.9236 3068509 PK04_093212 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K15 mock treatment 9120360.0 153000.0 0.13 9467720.0 713000.0 0.59 9978480.0 198533.33333333 0.166942640323296 0.5142 0.8179 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K16 mock treatment 8705000.0 -262000.0 -0.23 8639960.0 -115000.0 -0.1 9943520.0 163573.33333333 0.137545487675365 -0.1057 -0.3764 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K17 compound treatment 8607080.0 -360000.0 -0.31 8465160.0 -290000.0 -0.24 9774280.0 -5666.66666666977 -0.00476498469694028 -0.3202 -0.817 3187453 PK04_093213 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K18 compound treatment 8402480.0 -564000.0 -0.49 8168720.0 -586000.0 -0.49 9847280.0 67333.3333333302 0.0566192299283156 -0.5284 -0.7663 3187454 PK04_093214 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K19 compound treatment 2973120.0 -5990000.0 -5.16 2935000.0 -5820000.0 -4.83 3561760.0 -6218186.66666667 -5.22874664282974 -8.7844 -0.9994 3068511 PK04_093215 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K20 compound treatment 7590920.0 -1380000.0 -1.18 7275040.0 -1480000.0 -1.23 6939800.0 -2840146.66666667 -2.38822154183386 -2.7712 -0.9443 3187455 PK04_093216 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K21 compound treatment 8667400.0 -299000.0 -0.26 8575960.0 -179000.0 -0.15 9547440.0 -232506.66666667 -0.19551012504753 -0.3473 -0.9759 3068513 PK04_093217 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K22 compound treatment 6392000.0 -2570000.0 -2.22 4251720.0 -4500000.0 -3.74 6094560.0 -3685386.66666667 -3.09896665922908 -5.2253 -0.9793 3187456 PK04_093218 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K23 mock treatment 8889680.0 -77200.0 -0.07 8980920.0 226000.0 0.19 8550200.0 -1229746.66666667 -1.03406894960767 -0.527 -0.5005 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 K24 mock treatment 8214560.0 -752000.0 -0.65 8373520.0 -381000.0 -0.32 8324920.0 -1455026.66666667 -1.22350231770051 -1.2628 -0.8893 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L01 compound treatment 5066680.0 -3900000.0 -3.36 4567360.0 -4190000.0 -3.47 5404800.0 -4375146.66666667 -3.67897180826904 -6.0676 -0.9993 3187457 PK04_093219 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L02 compound treatment 4329040.0 -4640000.0 -3.99 4595960.0 -4160000.0 -3.45 4947840.0 -4832106.66666667 -4.06322017423009 -6.6422 -0.9975 3068516 PK04_093220 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L03 compound treatment 5838800.0 -3130000.0 -2.69 5566160.0 -3190000.0 -2.65 6785000.0 -2994946.66666667 -2.5183897120255 -4.5355 -0.9996 3187458 PK04_093221 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L04 compound treatment 8299280.0 -668000.0 -0.57 6485760.0 -2270000.0 -1.88 9073840.0 -706106.66666667 -0.593750728424532 -1.7612 -0.8568 3187459 PK04_093222 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L05 compound treatment 7236720.0 -1730000.0 -1.49 5075160.0 -3680000.0 -3.05 6929600.0 -2850346.66666667 -2.39679851428835 -4.0058 -0.9637 3068518 PK04_093223 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L06 compound treatment 7481880.0 -1490000.0 -1.28 6131320.0 -2620000.0 -2.18 7104720.0 -2675226.66666667 -2.24954366955993 -3.2931 -0.9741 3187460 PK04_093224 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L07 mock treatment 3374640.0 -5590000.0 -4.81 3095120.0 -5660000.0 -4.69 3662760.0 -6117186.66666667 -5.14381779793727 -8.4592 -0.9992 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L08 mock treatment 9119160.0 152000.0 0.13 7521880.0 -1230000.0 -1.02 9845200.0 65253.3333333302 0.054870200251322 -0.4831 -0.4679 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L09 compound treatment 6220400.0 -2750000.0 -2.36 4603240.0 -4150000.0 -3.44 7636320.0 -2143626.66666667 -1.80253204634368 -4.3937 -0.9658 3068520 PK04_093225 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L10 compound treatment 9211480.0 245000.0 0.21 8776560.0 21900.0 0.02 1.024028E7 460333.33333333 0.387084933321816 0.3555 0.8061 3187461 PK04_093226 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L11 compound treatment 7948440.0 -1020000.0 -0.88 5689960.0 -3060000.0 -2.54 7851400.0 -1928546.66666667 -1.62167565070532 -2.9102 -0.9267 3187462 PK04_093227 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L12 compound treatment 8907880.0 -59000.0 -0.05 8335200.0 -419000.0 -0.35 9900600.0 120653.33333333 0.101454932994324 -0.1716 -0.469 3187463 PK04_093228 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L13 compound treatment 4638240.0 -4330000.0 -3.73 4045160.0 -4710000.0 -3.91 5460200.0 -4319746.66666667 -3.63238707552603 -6.5037 -0.9995 3068543 PK04_093229 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L14 compound treatment 3913400.0 -5050000.0 -4.35 3320280.0 -5430000.0 -4.51 5172760.0 -4607186.66666667 -3.87408952281211 -7.3505 -0.998 3187464 PK04_093230 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L15 mock treatment 9061520.0 94600.0 0.08 8792320.0 37700.0 0.03 1.027076E7 490813.33333333 0.412714945126992 0.3033 0.7191 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L16 mock treatment 8845480.0 -121000.0 -0.1 8671480.0 -83200.0 -0.07 9935560.0 155613.33333333 0.130852085642255 -0.0246 -0.1359 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L17 compound treatment 8493160.0 -474000.0 -0.41 7881360.0 -873000.0 -0.72 9156720.0 -623226.66666667 -0.524058622833557 -0.9562 -0.9731 3068545 PK04_093231 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L18 compound treatment 4899680.0 -4070000.0 -3.5 3593600.0 -5160000.0 -4.28 5766560.0 -4013386.66666667 -3.37477518521654 -6.4413 -0.9942 3187465 PK04_093232 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L19 compound treatment 7400840.0 -1570000.0 -1.35 6679120.0 -2080000.0 -1.72 7863880.0 -1916066.66666667 -1.61118147264336 -2.7025 -0.995 3187466 PK04_093233 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L20 compound treatment 8786640.0 -180000.0 -0.16 8127240.0 -627000.0 -0.52 9284960.0 -494986.66666667 -0.416224216209683 -0.6304 -0.9212 3068547 PK04_093234 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L21 compound treatment 7918360.0 -1050000.0 -0.9 7082400.0 -1670000.0 -1.39 8252480.0 -1527466.66666667 -1.28441563972042 -2.0635 -0.985 3187467 PK04_093235 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L22 compound treatment 5600800.0 -3370000.0 -2.9 4600200.0 -4150000.0 -3.45 6378920.0 -3401026.66666667 -2.8598541212724 -5.3135 -0.9962 3068549 PK04_093236 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L23 mock treatment 9138080.0 171000.0 0.15 8298200.0 -456000.0 -0.38 9232880.0 -547066.66666667 -0.460017228506715 -0.3992 -0.6503 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 L24 mock treatment 8207920.0 -759000.0 -0.65 8187000.0 -568000.0 -0.47 8345400.0 -1434546.66666667 -1.20628110241935 -1.3455 -0.9277 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M01 compound treatment 4429680.0 -4540000.0 -3.9 4154640.0 -4600000.0 -3.82 4608480.0 -5171466.66666667 -4.34858109306881 -6.9683 -0.9983 3187528 PK04_093237 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M02 compound treatment 6168040.0 -2800000.0 -2.41 5646120.0 -3110000.0 -2.58 6633840.0 -3146106.66666667 -2.6454970802824 -4.4069 -0.9992 3187529 PK04_093238 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M03 compound treatment 8240920.0 -726000.0 -0.62 7537840.0 -1220000.0 -1.01 8988800.0 -791146.66666667 -0.665259134064693 -1.3276 -0.9756 3068551 PK04_093239 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M04 compound treatment 8419840.0 -547000.0 -0.47 7529720.0 -1220000.0 -1.02 9420200.0 -359746.66666667 -0.302503652019003 -1.0332 -0.8906 3187530 PK04_093240 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M05 compound treatment 8490560.0 -476000.0 -0.41 7766440.0 -988000.0 -0.82 9480480.0 -299466.66666667 -0.251815426572285 -0.8554 -0.8999 3068553 PK04_093241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M06 compound treatment 8078480.0 -888000.0 -0.76 6768680.0 -1990000.0 -1.65 8562040.0 -1217906.66666667 -1.02411293452324 -1.9839 -0.9515 3187531 PK04_093242 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M07 compound treatment 8563960.0 -403000.0 -0.35 8079240.0 -675000.0 -0.56 9322600.0 -457346.66666667 -0.384573506093318 -0.7457 -0.9774 3187532 PK04_093243 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M08 compound treatment 3759640.0 -5210000.0 -4.48 3636840.0 -5120000.0 -4.25 4633800.0 -5146146.66666667 -4.32729002027003 -7.537 -0.9997 3068555 PK04_093244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M09 mock treatment 8916960.0 -49900.0 -0.04 8432920.0 -322000.0 -0.27 9499040.0 -280906.66666667 -0.236208700223727 -0.3153 -0.8782 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M10 mock treatment 8953360.0 -13500.0 -0.01 8636960.0 -118000.0 -0.1 1.026704E7 487093.33333333 0.409586872820061 0.1734 0.4116 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M11 compound treatment 9292120.0 325000.0 0.28 8648000.0 -107000.0 -0.09 1.01028E7 322853.33333333 0.271480798709759 0.2673 0.6684 3187533 PK04_093245 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M12 compound treatment 4643800.0 -4320000.0 -3.72 3670200.0 -5080000.0 -4.22 4778040.0 -5001906.66666667 -4.20600153920774 -7.0117 -0.9984 3187534 PK04_093246 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M13 mock treatment 9039440.0 72600.0 0.06 8453680.0 -301000.0 -0.25 9603400.0 -176546.66666667 -0.148454499699183 -0.1938 -0.6523 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M14 mock treatment 9277960.0 311000.0 0.27 8688000.0 -66700.0 -0.06 1.012132E7 341373.33333333 0.287053889872221 0.2884 0.7275 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M15 compound treatment 8473680.0 -493000.0 -0.42 8309080.0 -446000.0 -0.37 9653960.0 -125986.66666667 -0.1059396244738 -0.5196 -0.9073 3068558 PK04_093247 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M16 compound treatment 8332160.0 -635000.0 -0.55 8617400.0 -137000.0 -0.11 9754680.0 -25266.6666666698 -0.0212462258839953 -0.3934 -0.7045 3187535 PK04_093248 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M17 compound treatment 8927920.0 -39000.0 -0.03 8510800.0 -244000.0 -0.2 1.003092E7 250973.33333333 0.211038369295192 -0.0143 -0.0487 3068560 PK04_093249 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M18 compound treatment 8177880.0 -789000.0 -0.68 7488520.0 -1270000.0 -1.05 8943080.0 -836866.66666667 -0.703704151772456 -1.4048 -0.9788 3187536 PK04_093250 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M19 compound treatment 8714600.0 -252000.0 -0.22 8355480.0 -399000.0 -0.33 9360880.0 -419066.66666667 -0.352384632999417 -0.52 -0.981 3187537 PK04_093251 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M20 compound treatment 9101040.0 134000.0 0.12 8927160.0 172000.0 0.14 9313880.0 -466066.66666667 -0.391905976662253 -0.077 -0.1778 3068562 PK04_093252 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCOCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M21 compound treatment 8570160.0 -397000.0 -0.34 8215200.0 -539000.0 -0.45 9674880.0 -105066.66666667 -0.0883484221455763 -0.5065 -0.8889 3068586 PK04_093253 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M22 compound treatment 7784000.0 -1180000.0 -1.02 7399480.0 -1360000.0 -1.12 8893560.0 -886386.66666667 -0.745344512159342 -1.6672 -0.9865 3187538 PK04_093254 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M23 compound treatment 2494720.0 -6470000.0 -5.57 2688080.0 -6070000.0 -5.03 2771680.0 -7008266.66666667 -5.89310883859854 -9.524 -0.9979 3068589 PK04_093255 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 M24 compound treatment 5389640.0 -3580000.0 -3.08 5660880.0 -3090000.0 -2.57 6046400.0 -3733546.66666667 -3.1394634232887 -5.0718 -0.9962 3187539 PK04_093256 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N01 compound treatment 4143720.0 -4820000.0 -4.15 3757680.0 -5000000.0 -4.15 4642480.0 -5137466.66666667 -4.31999118488719 -7.2841 -0.9998 3187540 PK04_093257 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N02 compound treatment 5346360.0 -3620000.0 -3.12 4967720.0 -3790000.0 -3.14 5742040.0 -4037906.66666667 -3.3953935542934 -5.5731 -0.9992 3187541 PK04_093258 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N03 compound treatment 3396880.0 -5570000.0 -4.79 2373560.0 -6380000.0 -5.29 3786840.0 -5993106.66666667 -5.03948145066738 -8.7335 -0.9992 3068594 PK04_093259 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CC=C)C3=O)[C@@H](O2)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N04 compound treatment 8372360.0 -595000.0 -0.51 7371120.0 -1380000.0 -1.15 9731320.0 -48626.6666666698 -0.0408891745640772 -0.9817 -0.7808 3187542 PK04_093260 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N05 compound treatment 7184560.0 -1780000.0 -1.53 5019000.0 -3740000.0 -3.1 7790160.0 -1989786.66666667 -1.67317112061835 -3.6408 -0.9478 3068597 PK04_093261 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N06 compound treatment 8536320.0 -431000.0 -0.37 9291840.0 537000.0 0.45 9652800.0 -127146.66666667 -0.106915044870585 -0.0184 -0.0312 3187543 PK04_093262 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N07 compound treatment 6980320.0 -1990000.0 -1.71 4090400.0 -4660000.0 -3.87 6532160.0 -3247786.66666667 -2.73099772333851 -4.7978 -0.9529 3187544 PK04_093263 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CC=C)C3=O)[C@H](O2)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N08 compound treatment 4046320.0 -4920000.0 -4.23 2636120.0 -6120000.0 -5.08 2971800.0 -6808146.66666667 -5.7248320025601 -8.6807 -0.9927 3068600 PK04_093264 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N09 mock treatment 8521720.0 -445000.0 -0.38 8381920.0 -373000.0 -0.31 9401600.0 -378346.66666667 -0.318144013553657 -0.5834 -0.9953 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N10 mock treatment 8982120.0 15200.0 0.01 8785600.0 30900.0 0.03 1.001128E7 231333.33333333 0.194523492922041 0.1347 0.685 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N11 compound treatment 5796720.0 -3170000.0 -2.73 3756040.0 -5000000.0 -4.15 5516480.0 -4263466.66666667 -3.58506236868892 -6.0392 -0.9863 3187545 PK04_093265 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N12 compound treatment 8721640.0 -245000.0 -0.21 8145120.0 -610000.0 -0.51 9347080.0 -432866.66666667 -0.363988772202547 -0.624 -0.9485 3187546 PK04_093266 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N13 mock treatment 8869520.0 -97400.0 -0.08 8770480.0 15800.0 0.01 9429520.0 -350426.66666667 -0.294666653658628 -0.2109 -0.6879 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N14 mock treatment 9010880.0 44000.0 0.04 8922760.0 168000.0 0.14 1.000208E7 222133.33333333 0.186787400119954 0.2102 0.8902 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N15 compound treatment 7258440.0 -1710000.0 -1.47 6008000.0 -2750000.0 -2.28 7126960.0 -2652986.66666667 -2.23084250609053 -3.4524 -0.9832 3068603 PK04_093267 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N16 compound treatment 8630280.0 -337000.0 -0.29 8184920.0 -570000.0 -0.47 9377720.0 -402226.66666667 -0.338224219652988 -0.6354 -0.9785 3187547 PK04_093268 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N17 compound treatment 7871680.0 -1100000.0 -0.94 4601040.0 -4150000.0 -3.45 5449160.0 -4330786.66666667 -3.64167038688854 -4.6361 -0.9088 3068605 PK04_093269 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N18 compound treatment 5308440.0 -3660000.0 -3.15 3806480.0 -4950000.0 -4.1 5328560.0 -4451386.66666667 -3.74308047296807 -6.3489 -0.9943 3187548 PK04_093270 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N19 compound treatment 8599520.0 -367000.0 -0.32 7471440.0 -1280000.0 -1.06 8802280.0 -977666.66666667 -0.822100006830484 -1.2718 -0.9205 3068607 PK04_093271 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N20 compound treatment 8257920.0 -709000.0 -0.61 8151360.0 -603000.0 -0.5 8606680.0 -1173266.66666667 -0.986576066840074 -1.2108 -0.9584 3186297 PK04_093272 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N21 compound treatment 5174040.0 -3790000.0 -3.26 5112480.0 -3640000.0 -3.02 5257400.0 -4522546.66666667 -3.80291746903291 -5.8247 -0.9953 3186298 PK04_093273 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CC=C)C3=O)[C@@H](O2)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N22 compound treatment 7958840.0 -1010000.0 -0.87 8528680.0 -226000.0 -0.19 8772840.0 -1007106.66666667 -0.846855503797163 -1.0981 -0.8951 3068610 PK04_093274 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N23 compound treatment 3904080.0 -5060000.0 -4.36 4079560.0 -4680000.0 -3.88 4289200.0 -5490746.66666667 -4.61705714848733 -7.4205 -0.9975 3068635 PK04_093275 CC(=O)N1Cc2ccccc2C[C@]3(N=C(O[C@@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 N24 compound treatment 6106760.0 -2860000.0 -2.46 6295720.0 -2460000.0 -2.04 6396720.0 -3383226.66666667 -2.84488646345967 -4.2414 -0.9911 3186299 PK04_093276 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O01 compound treatment 4300200.0 -4670000.0 -4.02 3819280.0 -4940000.0 -4.09 3986120.0 -5793826.66666667 -4.87191095353695 -7.4954 -0.996 3068638 PK04_093277 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O02 compound treatment 4450360.0 -4520000.0 -3.89 5001760.0 -3750000.0 -3.11 5645120.0 -4134826.66666667 -3.47689161020408 -6.0491 -0.9959 3186300 PK04_093278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O03 compound treatment 1055120.0 -7910000.0 -6.81 1357360.0 -7400000.0 -6.14 1210080.0 -8569866.66666667 -7.20622650378757 -11.6348 -0.9978 3068640 PK04_093279 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O04 compound treatment 8389040.0 -578000.0 -0.5 7883800.0 -871000.0 -0.72 9196200.0 -583746.66666667 -0.490860694156775 -0.9876 -0.9826 3186301 PK04_093280 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O05 compound treatment 7884880.0 -1080000.0 -0.93 7857800.0 -897000.0 -0.74 8620480.0 -1159466.66666667 -0.974971927636943 -1.5301 -0.9936 3068642 PK04_093281 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O06 compound treatment 8067320.0 -900000.0 -0.77 7782760.0 -972000.0 -0.81 8700480.0 -1079466.66666667 -0.907701555444882 -1.4365 -0.9977 3186302 PK04_093282 COCCCNC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O07 compound treatment 7812960.0 -1150000.0 -0.99 8456800.0 -298000.0 -0.25 9947960.0 168013.33333333 0.141278993332025 -0.6345 -0.6141 3186303 PK04_093283 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O08 compound treatment 5734480.0 -3230000.0 -2.78 4906680.0 -3850000.0 -3.19 6756520.0 -3023426.66666667 -2.54233796452587 -4.917 -0.9956 3068645 PK04_093284 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O09 compound treatment 983560.0 -7980000.0 -6.87 945840.0 -7810000.0 -6.48 1186400.0 -8593546.66666667 -7.22613853395642 -11.8789 -0.999 3186304 PK04_093285 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O10 compound treatment 3971440.0 -5000000.0 -4.3 4095120.0 -4660000.0 -3.87 4868320.0 -4911626.66666667 -4.130086924189 -7.0984 -0.9991 3186305 PK04_093286 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O11 mock treatment 9005400.0 38500.0 0.03 9042000.0 287000.0 0.24 1.035548E7 575533.33333333 0.483954269278384 0.4362 0.807 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O12 mock treatment 9064800.0 97900.0 0.08 9254240.0 500000.0 0.41 9771600.0 -8346.66666666977 -0.00701854216537433 0.2839 0.6711 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O13 compound treatment 7950880.0 -1020000.0 -0.87 7368320.0 -1390000.0 -1.15 9065520.0 -714426.66666667 -0.600746847132507 -1.5157 -0.9687 3068648 PK04_093287 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O14 compound treatment 8322560.0 -644000.0 -0.55 8601320.0 -153000.0 -0.13 8909960.0 -869986.66666667 -0.73155408585997 -0.816 -0.8805 3186306 PK04_093288 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O15 compound treatment 8216440.0 -750000.0 -0.65 8180640.0 -574000.0 -0.48 8904000.0 -875946.66666667 -0.736565728588278 -1.0731 -0.9852 3068650 PK04_093289 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O16 compound treatment 7009760.0 -1960000.0 -1.68 7081640.0 -1670000.0 -1.39 8245400.0 -1534546.66666667 -1.29036906765942 -2.5188 -0.9934 3186307 PK04_093290 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O17 compound treatment 4282480.0 -4680000.0 -4.03 4065160.0 -4690000.0 -3.89 4628480.0 -5151466.66666667 -4.3317635000208 -7.0746 -0.999 3186308 PK04_093291 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O18 compound treatment 7733280.0 -1230000.0 -1.06 7869080.0 -886000.0 -0.73 8559800.0 -1220146.66666667 -1.02599650494462 -1.6295 -0.9881 3068652 PK04_093292 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O19 compound treatment 4244080.0 -4720000.0 -4.06 3299280.0 -5460000.0 -4.53 3991520.0 -5788426.66666667 -4.86737020341399 -7.7698 -0.9973 3186309 PK04_093293 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O20 compound treatment 7986240.0 -981000.0 -0.84 6691240.0 -2060000.0 -1.71 7538040.0 -2241906.66666667 -1.88517369858163 -2.564 -0.9558 3068654 PK04_093294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O21 compound treatment 2203720.0 -6760000.0 -5.82 2117960.0 -6640000.0 -5.51 1857520.0 -7922426.66666667 -6.66180738163722 -10.3854 -0.9967 3186310 PK04_093295 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O22 compound treatment 7634520.0 -1330000.0 -1.15 7690680.0 -1060000.0 -0.88 8165920.0 -1614026.66666667 -1.35720218243223 -1.9552 -0.9855 3186311 PK04_093296 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O23 compound treatment 5787920.0 -3180000.0 -2.74 5916320.0 -2840000.0 -2.35 6254040.0 -3525906.66666667 -2.96486317226421 -4.6508 -0.9956 3068656 PK04_093297 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 O24 compound treatment 5988640.0 -2980000.0 -2.56 5982560.0 -2770000.0 -2.3 5984960.0 -3794986.66666667 -3.19112706913221 -4.65 -0.9904 3186312 PK04_093298 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P01 compound treatment 3716920.0 -5250000.0 -4.52 3426680.0 -5330000.0 -4.42 3642080.0 -6137866.66666667 -5.16120718914891 -8.1403 -0.9976 3186313 PK04_093299 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P02 compound treatment 2372080.0 -6590000.0 -5.68 2577120.0 -6180000.0 -5.12 2941080.0 -6838866.66666667 -5.75066382548185 -9.5558 -0.9987 3186314 PK04_093300 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P03 compound treatment 2912920.0 -6050000.0 -5.21 3269840.0 -5480000.0 -4.55 3362560.0 -6417386.66666667 -5.39624986958797 -8.7507 -0.9974 3067960 PK04_093301 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P04 compound treatment 2590440.0 -6380000.0 -5.49 2963720.0 -5790000.0 -4.8 2948880.0 -6831066.66666667 -5.74410496419312 -9.2583 -0.9973 3186315 PK04_093302 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P05 compound treatment 4227600.0 -4740000.0 -4.08 3959600.0 -4800000.0 -3.98 4562800.0 -5217146.66666667 -4.38699247559048 -7.1843 -0.9991 3186316 PK04_093303 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P06 compound treatment 3906520.0 -5060000.0 -4.36 3717760.0 -5040000.0 -4.18 4082480.0 -5697466.66666667 -4.79088379023162 -7.6929 -0.9983 3067963 PK04_093304 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P07 compound treatment 7825960.0 -1140000.0 -0.98 6949920.0 -1800000.0 -1.5 7738400.0 -2041546.66666667 -1.71669505142661 -2.4224 -0.9766 3186317 PK04_093305 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P08 compound treatment 5822400.0 -3140000.0 -2.71 5701600.0 -3050000.0 -2.53 6313280.0 -3466666.66666667 -2.91504946165599 -4.7077 -0.9984 3186362 PK04_093306 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P09 compound treatment 4622000.0 -4340000.0 -3.74 4350960.0 -4400000.0 -3.65 5004400.0 -4775546.66666667 -4.0156600210903 -6.5865 -0.9992 3067965 PK04_093307 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P10 compound treatment 7886040.0 -1080000.0 -0.93 7769160.0 -986000.0 -0.82 8512560.0 -1267386.66666667 -1.06571965972403 -1.6244 -0.9942 3186363 PK04_093308 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P11 mock treatment 8245760.0 -721000.0 -0.62 9227480.0 473000.0 0.39 9778960.0 -986.666666669771 -8.29667923704699E-4 -0.1323 -0.1803 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P12 mock treatment 8739080.0 -228000.0 -0.2 8800760.0 46100.0 0.04 9023240.0 -756706.66666667 -0.636299238836011 -0.4585 -0.6875 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P13 compound treatment 2088320.0 -6880000.0 -5.92 2133520.0 -6620000.0 -5.49 2450720.0 -7329226.66666667 -6.16299757183309 -10.1473 -0.9989 3186364 PK04_093309 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P14 compound treatment 8052640.0 -914000.0 -0.79 7121080.0 -1630000.0 -1.36 7800840.0 -1979106.66666667 -1.66419052593071 -2.1975 -0.9614 3067968 PK04_093310 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P15 compound treatment 7065680.0 -1900000.0 -1.64 6457040.0 -2300000.0 -1.91 7539760.0 -2240186.66666667 -1.8837273855795 -3.1327 -0.9977 3186365 PK04_093311 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P16 compound treatment 8173800.0 -793000.0 -0.68 8373080.0 -382000.0 -0.32 8444800.0 -1335146.66666667 -1.12269766497071 -1.225 -0.9064 3186366 PK04_093312 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P17 compound treatment 3751160.0 -5220000.0 -4.49 3974000.0 -4780000.0 -3.97 4772160.0 -5007786.66666667 -4.21094591156386 -7.3125 -0.9987 3067970 PK04_093313 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P18 compound treatment 7855240.0 -1110000.0 -0.96 8186840.0 -568000.0 -0.47 8425560.0 -1354386.66666667 -1.1388761894829 -1.4819 -0.9498 3186367 PK04_093314 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P19 compound treatment 6233760.0 -2730000.0 -2.35 5850600.0 -2900000.0 -2.41 6932120.0 -2847826.66666667 -2.3946794975643 -4.1315 -0.9999 3067972 PK04_093315 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CC=C)C3=O)[C@H](O2)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P20 compound treatment 6001240.0 -2970000.0 -2.55 6360520.0 -2390000.0 -1.99 6281680.0 -3498266.66666667 -2.94162125867185 -4.3186 -0.9878 3186368 PK04_093316 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P21 compound treatment 3903640.0 -5060000.0 -4.36 3609120.0 -5150000.0 -4.27 3966280.0 -5813666.66666667 -4.88859400584058 -7.8028 -0.9982 3067974 PK04_093317 CC(=O)N1Cc2ccccc2C[C@@]3(N=C(O[C@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P22 compound treatment 7565120.0 -1400000.0 -1.21 7613320.0 -1140000.0 -0.95 8382800.0 -1397146.66666667 -1.17483220341956 -1.9215 -0.9946 3186369 PK04_093318 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P23 compound treatment 7088880.0 -1880000.0 -1.62 7516040.0 -1240000.0 -1.03 7083960.0 -2695986.66666667 -2.26700033114377 -2.8353 -0.9554 3067976 PK04_093319 CC(=O)N1Cc2ccccc2C[C@@]3(COC(=N3)c4ccc(OCCCO)cc4)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2093 P24 compound treatment 4457200.0 -4510000.0 -3.88 4096520.0 -4660000.0 -3.86 4383360.0 -5396586.66666667 -4.53787992041727 -7.0918 -0.9971 3186370 PK04_093320 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A01 compound treatment 4345400.0 -5990000.0 -5.16 4626800.0 -5370000.0 -4.46 4683080.0 -4506342.5 -3.7892917149988 -7.7392 -0.9923 3186371 PK04_094001 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A02 compound treatment 3473560.0 -6860000.0 -5.91 3466280.0 -6530000.0 -5.42 3478320.0 -5711102.5 -4.80234988502514 -9.3131 -0.9965 3067979 PK04_094002 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A03 compound treatment 5827280.0 -4510000.0 -3.88 7460840.0 -2540000.0 -2.11 5387400.0 -3802022.5 -3.19704335821989 -5.3036 -0.9727 3068002 PK04_094003 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A04 compound treatment 8932840.0 -1410000.0 -1.21 8482320.0 -1520000.0 -1.26 7704560.0 -1484862.5 -1.24859066286293 -2.1463 -0.9998 3186372 PK04_094004 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A05 compound treatment 8793960.0 -1540000.0 -1.33 8390400.0 -1610000.0 -1.34 8055240.0 -1134182.5 -0.953710986359031 -2.0891 -0.9892 3068007 PK04_094005 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A06 compound treatment 6299040.0 -4040000.0 -3.48 4832840.0 -5170000.0 -4.29 6709080.0 -2480342.5 -2.08566953923485 -5.6862 -0.9637 3186373 PK04_094006 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A07 compound treatment 7547880.0 -2790000.0 -2.4 7681000.0 -2320000.0 -1.92 8017080.0 -1172342.5 -0.985798953894644 -3.0665 -0.949 3186374 PK04_094007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A08 compound treatment 6386920.0 -3950000.0 -3.4 7148720.0 -2850000.0 -2.37 7497360.0 -1692062.5 -1.42282092684037 -4.1506 -0.9476 3068010 PK04_094008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A09 compound treatment 8888520.0 -1450000.0 -1.25 9069920.0 -931000.0 -0.77 7940960.0 -1248462.5 -1.04980671303539 -1.7721 -0.9823 3186375 PK04_094009 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A10 compound treatment 6007640.0 -4330000.0 -3.73 6101480.0 -3900000.0 -3.23 5931240.0 -3258182.5 -2.73973936805826 -5.601 -0.9923 3068013 PK04_094010 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A11 compound treatment 3312600.0 -7030000.0 -6.05 2869640.0 -7130000.0 -5.92 2889120.0 -6300302.5 -5.29779617621967 -9.9649 -0.9984 3186376 PK04_094011 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A12 compound treatment 4462240.0 -5880000.0 -5.06 4057080.0 -5940000.0 -4.93 3911280.0 -5278142.5 -4.43828263072171 -8.3287 -0.9985 3186377 PK04_094012 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A13 mock treatment 8902600.0 -1440000.0 -1.24 8758240.0 -1240000.0 -1.03 8540000.0 -649422.5 -0.546086166061236 -1.6236 -0.9556 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A14 mock treatment 9165520.0 -1170000.0 -1.01 9287880.0 -713000.0 -0.59 8516880.0 -672542.5 -0.565527303624742 -1.2505 -0.9626 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A15 compound treatment 5281560.0 -5060000.0 -4.35 5247360.0 -4750000.0 -3.94 5332280.0 -3857142.5 -3.24339264466022 -6.6616 -0.993 3068016 PK04_094013 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A16 compound treatment 6253960.0 -4080000.0 -3.51 6572280.0 -3430000.0 -2.84 5800120.0 -3389302.5 -2.84999550808104 -5.3168 -0.9948 3186378 PK04_094014 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A17 compound treatment 8534640.0 -1800000.0 -1.55 8438600.0 -1560000.0 -1.3 8304760.0 -884662.5 -0.743894695491992 -2.0737 -0.9626 3068018 PK04_094015 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A18 compound treatment 2372960.0 -7960000.0 -6.85 2456840.0 -7540000.0 -6.26 2581360.0 -6608062.5 -5.55658529804253 -10.779 -0.9964 3186379 PK04_094016 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A19 compound treatment 4037880.0 -6300000.0 -5.42 3771080.0 -6230000.0 -5.17 3162120.0 -6027302.5 -5.06823603111426 -9.0403 -0.9996 3186380 PK04_094017 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A20 compound treatment 7327480.0 -3010000.0 -2.59 6197080.0 -3800000.0 -3.16 5545320.0 -3644102.5 -3.06425164351276 -5.0868 -0.9965 3068020 PK04_094018 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A21 compound treatment 7869000.0 -2470000.0 -2.12 7921560.0 -2080000.0 -1.72 7690120.0 -1499302.5 -1.2607329650436 -2.9505 -0.9792 3186381 PK04_094019 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A22 compound treatment 8252720.0 -2090000.0 -1.79 7957800.0 -2040000.0 -1.69 7832560.0 -1356862.5 -1.14095806735563 -2.6733 -0.9831 3186437 PK04_094020 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A23 compound treatment 8184320.0 -2150000.0 -1.85 7492040.0 -2510000.0 -2.08 6890760.0 -2298662.5 -1.93289852398667 -3.3876 -0.9988 3068021 PK04_094021 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 A24 compound treatment 8170280.0 -2170000.0 -1.87 8359360.0 -1640000.0 -1.36 7582080.0 -1607342.5 -1.35158160268898 -2.6435 -0.9879 3186438 PK04_094022 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B01 compound treatment 6120680.0 -4220000.0 -3.63 6522000.0 -3480000.0 -2.89 6313000.0 -2876422.5 -2.41872515195774 -5.1581 -0.9863 3186439 PK04_094023 CCCN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B02 compound treatment 4958320.0 -5380000.0 -4.63 7247080.0 -2750000.0 -2.28 5115920.0 -4073502.5 -3.42532536625365 -5.9695 -0.9635 3089331 PK04_094024 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B03 compound treatment 8410080.0 -1930000.0 -1.66 8040200.0 -1960000.0 -1.63 5013920.0 -4175502.5 -3.51109509079853 -3.924 -0.932 3068022 PK04_094025 CCCN1C(=O)[C@]2(Cc3ccccc13)N=C(O[C@@H]2c4ccccc4)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B04 compound treatment 5428520.0 -4910000.0 -4.23 4459760.0 -5540000.0 -4.6 2633920.0 -6555502.5 -5.51238866351235 -8.2759 -0.9937 3089332 PK04_094026 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B05 compound treatment 8781840.0 -1560000.0 -1.34 7440000.0 -2560000.0 -2.12 8208840.0 -980582.5 -0.824551871750273 -2.4757 -0.9367 3186440 PK04_094027 CCCN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B06 compound treatment 7471520.0 -2870000.0 -2.47 3625080.0 -6380000.0 -5.29 6604960.0 -2584462.5 -2.17322192864281 -5.7326 -0.9205 3000708 PK04_094028 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B07 compound treatment 8076320.0 -2260000.0 -1.95 5493600.0 -4510000.0 -3.74 7087000.0 -2102422.5 -1.76788430099955 -4.3031 -0.9414 3068023 PK04_094029 CN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B08 compound treatment 8720840.0 -1620000.0 -1.39 6423360.0 -3580000.0 -2.97 6879840.0 -2309582.5 -1.94208092979089 -3.6381 -0.9549 3089333 PK04_094030 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B09 compound treatment 9523320.0 -815000.0 -0.7 7495520.0 -2510000.0 -2.08 8170000.0 -1019422.5 -0.857211637449519 -2.0995 -0.8916 3186441 PK04_094031 CN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B10 compound treatment 6412040.0 -3930000.0 -3.38 5406280.0 -4590000.0 -3.81 5063680.0 -4125742.5 -3.46925291929506 -6.1542 -0.9986 3089654 PK04_094032 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B11 compound treatment 4407320.0 -5930000.0 -5.1 4024240.0 -5980000.0 -4.96 4040440.0 -5148982.5 -4.32967461481762 -8.309 -0.9976 3186442 PK04_094033 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B12 compound treatment 3410400.0 -6930000.0 -5.96 1820560.0 -8180000.0 -6.79 925720.0 -8263702.5 -6.94877928574333 -11.372 -0.9978 3089334 PK04_094034 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B13 mock treatment 1.006068E7 -277000.0 -0.24 1.021032E7 210000.0 0.17 9056800.0 -132622.5 -0.11151956170052 -0.1017 -0.3224 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B14 mock treatment 1.014404E7 -194000.0 -0.17 9925800.0 -74900.0 -0.06 8954120.0 -235302.5 -0.197861084409031 -0.2464 -0.9259 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B15 compound treatment 8669320.0 -1670000.0 -1.44 8096440.0 -1900000.0 -1.58 7925600.0 -1263822.5 -1.06272262449627 -2.3547 -0.9874 3068024 PK04_094035 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B16 compound treatment 5513240.0 -4820000.0 -4.15 5201360.0 -4800000.0 -3.98 4702280.0 -4487142.5 -3.7731468256727 -6.8744 -0.9992 3000709 PK04_094036 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B17 compound treatment 7133440.0 -3200000.0 -2.76 7816280.0 -2180000.0 -1.81 7338920.0 -1850502.5 -1.55604989896675 -3.5369 -0.9694 3186443 PK04_094037 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B18 compound treatment 4666480.0 -5670000.0 -4.88 4410200.0 -5590000.0 -4.64 3122040.0 -6067382.5 -5.10193848758249 -8.4413 -0.9992 3089363 PK04_094038 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B19 compound treatment 5140880.0 -5200000.0 -4.47 5522200.0 -4480000.0 -3.72 5190160.0 -3999262.5 -3.36289846085942 -6.6689 -0.9928 3068025 PK04_094039 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B20 compound treatment 5796840.0 -4540000.0 -3.91 4736240.0 -5260000.0 -4.37 4318640.0 -4870782.5 -4.09574189551973 -7.1425 -0.999 3089652 PK04_094040 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B21 compound treatment 5208720.0 -5130000.0 -4.41 5116800.0 -4880000.0 -4.05 5921120.0 -3268302.5 -2.74824907014055 -6.4745 -0.9822 3186444 PK04_094041 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B22 compound treatment 4592760.0 -5750000.0 -4.94 3932680.0 -6070000.0 -5.03 3737880.0 -5451542.5 -4.584091162448 -8.4076 -0.9992 3089653 PK04_094042 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B23 compound treatment 2927040.0 -7410000.0 -6.38 4425400.0 -5580000.0 -4.63 3034360.0 -6155062.5 -5.17566681550499 -9.3409 -0.9909 3186445 PK04_094043 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 B24 compound treatment 7754440.0 -2580000.0 -2.22 7140000.0 -2860000.0 -2.37 6446920.0 -2742502.5 -2.30611454890823 -3.9853 -0.9996 3089657 PK04_094044 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C01 compound treatment 8340440.0 -2000000.0 -1.72 7585160.0 -2420000.0 -2.0 7262480.0 -1926942.5 -1.62032673959626 -3.0849 -0.9959 3068026 PK04_094045 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C02 compound treatment 7850840.0 -2490000.0 -2.14 7477480.0 -2520000.0 -2.09 5345960.0 -3843462.5 -3.23188941101538 -4.3102 -0.9784 3068051 PK04_094046 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C03 compound treatment 9860000.0 -478000.0 -0.41 9205360.0 -795000.0 -0.66 7839160.0 -1350262.5 -1.13540826164979 -1.2739 -0.9257 3068052 PK04_094047 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C04 compound treatment 9912840.0 -425000.0 -0.37 9745720.0 -255000.0 -0.21 8495880.0 -693542.5 -0.583185776325158 -0.67 -0.9304 3068053 PK04_094048 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCOCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C05 compound treatment 9938760.0 -399000.0 -0.34 8415240.0 -1590000.0 -1.32 9191360.0 1937.5 0.00162920432652648 -0.9568 -0.7038 3068054 PK04_094049 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C06 compound treatment 1.04624E7 125000.0 0.11 9387440.0 -613000.0 -0.51 8797320.0 -392102.5 -0.329711013905471 -0.4222 -0.6858 3186446 PK04_094050 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C07 compound treatment 1.096712E7 629000.0 0.54 9820320.0 -180000.0 -0.15 8736480.0 -452942.5 -0.380870131957534 0.0064 0.0094 3068055 PK04_094051 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C08 compound treatment 1.05972E7 259000.0 0.22 9500440.0 -500000.0 -0.42 9503000.0 313577.5 0.263680939200701 0.0415 0.0768 3186447 PK04_094052 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C09 compound treatment 1.038652E7 48600.0 0.04 9280960.0 -720000.0 -0.6 8820680.0 -368742.5 -0.310068065225389 -0.4996 -0.7411 3068056 PK04_094053 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C10 compound treatment 9449320.0 -889000.0 -0.76 4818160.0 -5180000.0 -4.3 5735080.0 -3454342.5 -2.90468632067319 -4.6007 -0.8772 3186448 PK04_094054 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C11 mock treatment 1.070908E7 371000.0 0.32 9941880.0 -58800.0 -0.05 9214320.0 24897.5 0.0209358011456481 0.1683 0.5198 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C12 mock treatment 1.021232E7 -126000.0 -0.11 9673040.0 -328000.0 -0.27 9411280.0 221857.5 0.186555457482503 -0.1116 -0.3217 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C13 compound treatment 1.025476E7 -83100.0 -0.07 1.029736E7 297000.0 0.25 9799320.0 609897.5 0.512850397800096 0.3969 0.6922 3186449 PK04_094055 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C14 compound treatment 9402080.0 -936000.0 -0.81 8242640.0 -1760000.0 -1.46 8125960.0 -1063462.5 -0.894243977341249 -1.8233 -0.9643 3068057 PK04_094056 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C15 mock treatment 1.02444E7 -93500.0 -0.08 9851320.0 -149000.0 -0.12 9290920.0 101497.5 0.0853471825195467 -0.0687 -0.4028 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C16 mock treatment 1.023768E7 -100000.0 -0.09 1.012136E7 121000.0 0.1 9050880.0 -138542.5 -0.116497569242733 -0.0593 -0.3365 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C17 compound treatment 1.032292E7 -15000.0 -0.01 9175680.0 -825000.0 -0.68 9098440.0 -90982.5 -0.0765053329745526 -0.4468 -0.6486 3186450 PK04_094057 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C18 compound treatment 9798680.0 -539000.0 -0.46 7590360.0 -2410000.0 -2.0 8186600.0 -1002822.5 -0.843253035219666 -1.9092 -0.8603 3186451 PK04_094058 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C19 compound treatment 1.095904E7 621000.0 0.53 9336280.0 -664000.0 -0.55 9236720.0 47297.5 0.0397715053594252 0.0134 0.0174 3068058 PK04_094059 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C20 compound treatment 4952560.0 -5390000.0 -4.63 3451440.0 -6550000.0 -5.43 3578720.0 -5610702.5 -4.7179255679241 -8.5366 -0.9974 3186452 PK04_094060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C21 compound treatment 1.017176E7 -166000.0 -0.14 9237080.0 -764000.0 -0.63 8719320.0 -470102.5 -0.395299626792731 -0.6765 -0.8898 3068059 PK04_094061 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C22 compound treatment 9961840.0 -376000.0 -0.32 9199560.0 -801000.0 -0.66 8814600.0 -374822.5 -0.315180613511986 -0.7525 -0.9364 3186453 PK04_094062 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C23 compound treatment 9381720.0 -956000.0 -0.82 9050320.0 -950000.0 -0.79 8822520.0 -366902.5 -0.308520846664972 -1.1084 -0.9388 3186454 PK04_094063 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 C24 compound treatment 9137560.0 -1200000.0 -1.03 8565840.0 -1430000.0 -1.19 8481040.0 -708382.5 -0.595664430366785 -1.6276 -0.966 3068060 PK04_094064 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D01 compound treatment 6275040.0 -4060000.0 -3.5 8381280.0 -1620000.0 -1.34 5839720.0 -3349702.5 -2.81669667384597 -4.4206 -0.9432 3186455 PK04_094065 CN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D02 compound treatment 8302800.0 -2040000.0 -1.75 7645600.0 -2360000.0 -1.95 7332320.0 -1857102.5 -1.56159970467259 -3.0408 -0.9959 3000713 PK04_094066 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D03 compound treatment 9051880.0 -1290000.0 -1.11 8254880.0 -1750000.0 -1.45 6634480.0 -2554942.5 -2.14839916130394 -2.7156 -0.9638 3186456 PK04_094067 CCCN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D04 compound treatment 8885160.0 -1450000.0 -1.25 7811360.0 -2190000.0 -1.82 7591200.0 -1598222.5 -1.34391278025908 -2.5464 -0.9861 3089658 PK04_094068 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D05 compound treatment 1.052044E7 183000.0 0.16 8410560.0 -1590000.0 -1.32 8936560.0 -252862.5 -0.212626931105188 -0.7937 -0.5899 3068061 PK04_094069 CCCN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D06 compound treatment 9994400.0 -343000.0 -0.3 9444280.0 -556000.0 -0.46 8562400.0 -627022.5 -0.527250461847459 -0.7416 -0.975 3089659 PK04_094070 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D07 compound treatment 6163040.0 -4170000.0 -3.59 5840200.0 -4160000.0 -3.45 5876520.0 -3312902.5 -2.78575230263763 -5.6755 -0.9943 3186457 PK04_094071 CCCN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D08 compound treatment 1.02418E7 -96100.0 -0.08 9132640.0 -868000.0 -0.72 8968520.0 -220902.5 -0.18575241741446 -0.5708 -0.7627 3089664 PK04_094072 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D09 compound treatment 9859640.0 -478000.0 -0.41 8677120.0 -1320000.0 -1.1 8769400.0 -420022.5 -0.3531883738005 -1.0755 -0.8782 3068062 PK04_094073 CCCN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D10 compound treatment 7851600.0 -2490000.0 -2.14 6604840.0 -3400000.0 -2.82 5941200.0 -3248222.5 -2.73136420672034 -4.4388 -0.9932 3000714 PK04_094074 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D11 mock treatment 1.027444E7 -63400.0 -0.05 1.088536E7 885000.0 0.73 9661720.0 472297.5 0.39714535762975 0.6215 0.7432 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D12 mock treatment 1.100596E7 668000.0 0.57 1.049268E7 492000.0 0.41 9386000.0 196577.5 0.165298019869811 0.663 0.9155 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D13 compound treatment 9526680.0 -811000.0 -0.7 6631280.0 -3370000.0 -2.8 6574840.0 -2614582.5 -2.19854922377312 -3.2862 -0.9068 3186504 PK04_094075 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D14 compound treatment 9802480.0 -535000.0 -0.46 9623800.0 -377000.0 -0.31 8624200.0 -565222.5 -0.475284099329091 -0.721 -0.9848 3089660 PK04_094076 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D15 mock treatment 1.044172E7 104000.0 0.09 1.023556E7 235000.0 0.19 8694560.0 -494862.5 -0.416119806986174 -0.0762 -0.1627 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D16 mock treatment 1.015256E7 -185000.0 -0.16 1.051E7 509000.0 0.42 9103160.0 -86262.5 -0.072536381015221 0.11 0.2404 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D17 compound treatment 8388520.0 -1950000.0 -1.68 7630000.0 -2370000.0 -1.97 7526920.0 -1662502.5 -1.3979645243154 -2.9112 -0.9906 3186505 PK04_094077 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D18 compound treatment 1.027052E7 -67400.0 -0.06 9641880.0 -359000.0 -0.3 8554440.0 -634982.5 -0.533943863880569 -0.5136 -0.8364 3000715 PK04_094078 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D19 compound treatment 9976320.0 -362000.0 -0.31 8554040.0 -1450000.0 -1.2 8598400.0 -591022.5 -0.496978794361031 -1.1595 -0.8681 3068063 PK04_094079 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D20 compound treatment 9680240.0 -658000.0 -0.57 9120240.0 -880000.0 -0.73 8159760.0 -1029662.5 -0.865822245090103 -1.2484 -0.9858 3089662 PK04_094080 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D21 compound treatment 7370280.0 -2970000.0 -2.55 5012000.0 -4990000.0 -4.14 5362120.0 -3827302.5 -3.21830079583258 -5.722 -0.9812 3186506 PK04_094081 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D22 compound treatment 9487720.0 -850000.0 -0.73 8787440.0 -1210000.0 -1.01 8412600.0 -776822.5 -0.653214233777093 -1.3807 -0.9824 3000716 PK04_094082 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D23 compound treatment 7642680.0 -2700000.0 -2.32 5649520.0 -4350000.0 -3.61 5761360.0 -3428062.5 -2.8825880034081 -5.0875 -0.9842 3068064 PK04_094083 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 D24 compound treatment 2700560.0 -7640000.0 -6.57 2596360.0 -7400000.0 -6.14 2333760.0 -6855662.5 -5.76478709997696 -10.6696 -0.9986 3000811 PK04_094084 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E01 mock treatment 9863160.0 -475000.0 -0.41 9208240.0 -792000.0 -0.66 8817160.0 -372262.5 -0.31302796160184 -0.7962 -0.9536 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E02 mock treatment 1.010348E7 -234000.0 -0.2 9934080.0 -66600.0 -0.06 8628560.0 -560862.5 -0.471617864044624 -0.4207 -0.8154 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E03 compound treatment 1.002412E7 -314000.0 -0.27 8902320.0 -1100000.0 -0.91 8195560.0 -993862.5 -0.835718753534155 -1.1645 -0.9201 3186507 PK04_094085 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E04 compound treatment 9332240.0 -1010000.0 -0.87 8804680.0 -1200000.0 -0.99 8125320.0 -1064102.5 -0.894782140318785 -1.5891 -0.9983 3186508 PK04_094086 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E05 compound treatment 1.033368E7 -4200.0 0.0 9307120.0 -694000.0 -0.58 9132800.0 -56622.5 -0.0476127081180623 -0.3618 -0.6266 3068065 PK04_094087 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E06 compound treatment 1.08536E7 516000.0 0.44 9736600.0 -264000.0 -0.22 9019680.0 -169742.5 -0.142733014397637 0.0473 0.0919 3186509 PK04_094088 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E07 compound treatment 7778080.0 -2560000.0 -2.2 4067800.0 -5930000.0 -4.92 5348240.0 -3841182.5 -3.2299722054079 -5.9784 -0.9511 3068066 PK04_094089 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E08 compound treatment 1.049496E7 157000.0 0.14 1.00774E7 76700.0 0.06 9242360.0 52937.5 0.0445140665989655 0.1405 0.9011 3186510 PK04_094090 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E09 mock treatment 1.121028E7 872000.0 0.75 1.051724E7 517000.0 0.43 9930480.0 741057.5 0.62314017300898 1.0406 0.9765 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E10 mock treatment 1.063552E7 298000.0 0.26 1.038624E7 386000.0 0.32 9533960.0 344537.5 0.289714573239029 0.4998 0.996 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E11 compound treatment 7628920.0 -2710000.0 -2.33 5246880.0 -4750000.0 -3.94 4900280.0 -4289142.5 -3.60665265449735 -5.7052 -0.9785 3186511 PK04_094091 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E12 compound treatment 1.085876E7 521000.0 0.45 1.087184E7 871000.0 0.72 9432000.0 242577.5 0.203978483880247 0.7938 0.9077 3068067 PK04_094092 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E13 compound treatment 1.075696E7 419000.0 0.36 9093640.0 -907000.0 -0.75 8793360.0 -396062.5 -0.333040897328978 -0.4185 -0.4658 3186512 PK04_094093 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E14 compound treatment 1.106804E7 730000.0 0.63 9101720.0 -899000.0 -0.75 8606320.0 -583102.5 -0.490319027514017 -0.3509 -0.3214 3068068 PK04_094094 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E15 compound treatment 1.055076E7 213000.0 0.18 1.034852E7 348000.0 0.29 9293400.0 103977.5 0.0874325640575006 0.3228 0.9151 3186513 PK04_094095 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E16 compound treatment 1.075288E7 415000.0 0.36 9523600.0 -477000.0 -0.4 9366400.0 176977.5 0.148816778682756 0.0636 0.1149 3068069 PK04_094096 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E17 mock treatment 1.031388E7 -24000.0 -0.02 1.024196E7 241000.0 0.2 9205640.0 16217.5 0.0136369657628094 0.1115 0.5529 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E18 mock treatment 1.096764E7 630000.0 0.54 1.01606E7 160000.0 0.13 9398320.0 208897.5 0.175657657187389 0.4909 0.8392 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E19 compound treatment 1.100212E7 664000.0 0.57 9478520.0 -522000.0 -0.43 9262720.0 73297.5 0.0616343763218451 0.1155 0.1605 3186514 PK04_094097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E20 compound treatment 4510640.0 -5830000.0 -5.02 3166840.0 -6830000.0 -5.67 3205440.0 -5983982.5 -5.03180912457226 -9.0737 -0.9983 3186515 PK04_094098 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E21 compound treatment 6022960.0 -4310000.0 -3.71 4757840.0 -5240000.0 -4.35 4644120.0 -4545302.5 -3.82205238625633 -6.8618 -0.9976 3068070 PK04_094099 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E22 compound treatment 8878720.0 -1460000.0 -1.26 7588680.0 -2410000.0 -2.0 7726240.0 -1463182.5 -1.23036039199888 -2.5906 -0.9726 3186516 PK04_094100 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E23 compound treatment 9000600.0 -1340000.0 -1.15 9000400.0 -1000000.0 -0.83 8915880.0 -273542.5 -0.230016322316836 -1.2764 -0.888 3068071 PK04_094101 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 E24 compound treatment 7531440.0 -2810000.0 -2.42 5901960.0 -4100000.0 -3.4 5812560.0 -3376862.5 -2.83953496520518 -4.997 -0.9904 3186517 PK04_094102 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F01 mock treatment 9608240.0 -730000.0 -0.63 9501960.0 -499000.0 -0.41 8288080.0 -901342.5 -0.757920568094037 -1.039 -0.9731 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F02 mock treatment 1.009248E7 -245000.0 -0.21 9599440.0 -401000.0 -0.33 9106560.0 -82862.5 -0.0696773901970584 -0.3544 -0.8851 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F03 compound treatment 9391240.0 -947000.0 -0.81 8077800.0 -1920000.0 -1.6 5176280.0 -4013142.5 -3.37456987043474 -3.3397 -0.8741 3068072 PK04_094103 CN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F04 compound treatment 2657960.0 -7680000.0 -6.61 2487800.0 -7510000.0 -6.23 2407560.0 -6781862.5 -5.70273018162978 -10.7069 -0.9982 3000813 PK04_094104 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F05 compound treatment 8627800.0 -1710000.0 -1.47 8019320.0 -1980000.0 -1.64 7155560.0 -2033862.5 -1.71023359203095 -2.7861 -0.9981 3186518 PK04_094105 CN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F06 compound treatment 2902880.0 -7430000.0 -6.4 722760.0 -9280000.0 -7.7 1775840.0 -7413582.5 -6.2339306756444 -11.7372 -0.9954 3000814 PK04_094106 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F07 compound treatment 7198680.0 -3140000.0 -2.7 4596640.0 -5400000.0 -4.48 5191840.0 -3997582.5 -3.36148578304338 -6.0889 -0.9788 3186519 PK04_094107 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F08 compound treatment 7987240.0 -2350000.0 -2.02 6705760.0 -3290000.0 -2.73 6168800.0 -3020622.5 -2.53997999783393 -4.2126 -0.9925 3089667 PK04_094108 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F09 mock treatment 1.150244E7 1160000.0 1.0 9686880.0 -314000.0 -0.26 9106520.0 -82902.5 -0.0697110253831544 0.3881 0.3739 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F10 mock treatment 1.110652E7 769000.0 0.66 9691120.0 -310000.0 -0.26 9359440.0 170017.5 0.142964256302047 0.3162 0.4368 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F11 compound treatment 9641760.0 -696000.0 -0.6 7521160.0 -2480000.0 -2.06 6949960.0 -2239462.5 -1.88311844856455 -2.6207 -0.9188 3068073 PK04_094109 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F12 compound treatment 7624880.0 -2710000.0 -2.33 6798520.0 -3200000.0 -2.66 6344680.0 -2844742.5 -2.39208608456968 -4.2628 -0.9984 3089654 PK04_094110 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F13 compound treatment 1.006604E7 -272000.0 -0.23 8812000.0 -1190000.0 -0.99 7784120.0 -1405302.5 -1.18169027771793 -1.3867 -0.8907 3186520 PK04_094111 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F14 compound treatment 2263160.0 -8070000.0 -6.95 1877120.0 -8120000.0 -6.74 1477520.0 -7711902.5 -6.48478189354859 -11.6471 -0.9996 3089708 PK04_094112 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F15 compound treatment 5901360.0 -4440000.0 -3.82 4116640.0 -5880000.0 -4.88 4043880.0 -5145542.5 -4.32678198881336 -7.5207 -0.995 3186521 PK04_094113 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F16 compound treatment 5442360.0 -4900000.0 -4.21 3702600.0 -6300000.0 -5.22 3931920.0 -5257502.5 -4.42092687469615 -8.0015 -0.9956 3000817 PK04_094114 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F17 mock treatment 1.116556E7 828000.0 0.71 1.085468E7 854000.0 0.71 9701120.0 511697.5 0.430276015934341 1.0687 0.9779 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F18 mock treatment 1.108668E7 749000.0 0.64 9885360.0 -115000.0 -0.1 9159760.0 -29662.5 -0.0249425926893377 0.3024 0.4638 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F19 compound treatment 5114400.0 -5220000.0 -4.5 3985600.0 -6020000.0 -4.99 3469360.0 -5720062.5 -4.80988416671065 -8.2534 -0.9991 3068074 PK04_094115 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F20 compound treatment 4527840.0 -5810000.0 -5.0 3185240.0 -6820000.0 -5.65 2236400.0 -6953022.5 -5.8466551429347 -9.5268 -0.9978 3089709 PK04_094116 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F21 compound treatment 7891320.0 -2450000.0 -2.11 6629800.0 -3370000.0 -2.8 6431080.0 -2758342.5 -2.31943408260226 -4.1693 -0.9929 3186522 PK04_094117 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F22 compound treatment 6973920.0 -3360000.0 -2.9 6215920.0 -3780000.0 -3.14 5982800.0 -3206622.5 -2.69638361318047 -5.041 -0.9981 3000821 PK04_094118 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F23 compound treatment 8017320.0 -2320000.0 -2.0 5128080.0 -4870000.0 -4.04 5702000.0 -3487422.5 -2.93250261957461 -5.1799 -0.9631 3186523 PK04_094119 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 F24 compound treatment 2323960.0 -8010000.0 -6.9 1176600.0 -8820000.0 -7.32 2047320.0 -7142102.5 -6.00564866761064 -11.6757 -0.9967 3089711 PK04_094120 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G01 compound treatment 8481640.0 -1860000.0 -1.6 8533080.0 -1470000.0 -1.22 8012320.0 -1177102.5 -0.989801541040072 -2.1967 -0.981 3068075 PK04_094121 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G02 compound treatment 1.037616E7 38300.0 0.03 9333000.0 -668000.0 -0.55 8360200.0 -829222.5 -0.697276327562893 -0.7034 -0.7893 3186524 PK04_094122 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G03 mock treatment 1.008904E7 -249000.0 -0.21 9392200.0 -609000.0 -0.5 8922880.0 -266542.5 -0.224130164750031 -0.5445 -0.9191 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G04 mock treatment 1.0536E7 198000.0 0.17 9824680.0 -176000.0 -0.15 9036120.0 -153302.5 -0.128908952912168 -0.0603 -0.2329 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G05 compound treatment 1.066668E7 329000.0 0.28 1.013192E7 131000.0 0.11 9571680.0 382257.5 0.321432553727586 0.4118 0.932 3186575 PK04_094123 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G06 compound treatment 1.044796E7 110000.0 0.09 9725440.0 -275000.0 -0.23 9193520.0 4097.5 0.00344550437571214 -0.0752 -0.304 3186576 PK04_094124 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G07 compound treatment 1.079652E7 459000.0 0.39 9849680.0 -151000.0 -0.13 9871240.0 681817.5 0.573326462400759 0.4866 0.688 3068110 PK04_094125 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G08 compound treatment 1.10912E7 753000.0 0.65 1.013616E7 135000.0 0.11 9790200.0 600777.5 0.505181575370201 0.7309 0.881 3186577 PK04_094126 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G09 compound treatment 9498400.0 -839000.0 -0.72 7371800.0 -2630000.0 -2.18 7619160.0 -1570262.5 -1.32040178517796 -2.4386 -0.9203 3068111 PK04_094127 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G10 compound treatment 9744800.0 -593000.0 -0.51 9463680.0 -537000.0 -0.45 8815200.0 -374222.5 -0.314676085720545 -0.7336 -0.982 3186578 PK04_094128 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G11 compound treatment 1.052812E7 190000.0 0.16 1.006788E7 67200.0 0.06 9042080.0 -147342.5 -0.12389731018386 0.0552 0.2593 3186579 PK04_094129 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G12 compound treatment 1.149716E7 1160000.0 1.0 1.054184E7 541000.0 0.45 9592680.0 403257.5 0.339091026428002 1.031 0.9001 3068112 PK04_094130 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G13 compound treatment 1.134464E7 1010000.0 0.87 1.115724E7 1160000.0 0.96 9679920.0 490497.5 0.412449367303444 1.2923 0.9523 3186580 PK04_094131 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCCN3CCOCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G14 compound treatment 1.0754E7 416000.0 0.36 1.004056E7 39800.0 0.03 8919920.0 -269502.5 -0.226619168521137 0.095 0.2235 3186581 PK04_094132 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G15 compound treatment 1.073028E7 392000.0 0.34 1.0567E7 566000.0 0.47 9556160.0 366737.5 0.308382101522326 0.6442 0.9827 3068113 PK04_094133 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G16 compound treatment 8349080.0 -1990000.0 -1.71 8243040.0 -1760000.0 -1.46 7437920.0 -1751502.5 -1.47280281337907 -2.6804 -0.9972 3186582 PK04_094134 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G17 compound treatment 1.071876E7 381000.0 0.33 1.049596E7 495000.0 0.41 9000600.0 -188822.5 -0.158776998165443 0.3348 0.6098 3186583 PK04_094135 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G18 compound treatment 1.024812E7 -89800.0 -0.08 8532400.0 -1470000.0 -1.22 8247400.0 -942022.5 -0.7921275523537 -1.2052 -0.8283 3068114 PK04_094136 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G19 mock treatment 1.03398E7 1920.0 0.0 1.005684E7 56100.0 0.05 9391040.0 201617.5 0.169536053317911 0.1257 0.715 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G20 mock treatment 1.04368E7 98900.0 0.09 1.078656E7 786000.0 0.65 9328720.0 139297.5 0.117132433380296 0.4932 0.7385 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G21 compound treatment 9567320.0 -771000.0 -0.66 8966760.0 -1030000.0 -0.86 8140640.0 -1048782.5 -0.881899864044005 -1.3873 -0.9926 3186584 PK04_094137 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G22 compound treatment 1.001468E7 -323000.0 -0.28 9617240.0 -383000.0 -0.32 8874480.0 -314942.5 -0.264828739926228 -0.4972 -0.9969 3068115 PK04_094138 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G23 compound treatment 9026000.0 -1310000.0 -1.13 8600280.0 -1400000.0 -1.16 8440800.0 -748622.5 -0.629501427579392 -1.686 -0.9701 3186585 PK04_094139 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 G24 compound treatment 9313320.0 -1020000.0 -0.88 8572320.0 -1430000.0 -1.18 8466960.0 -722462.5 -0.607504015872588 -1.544 -0.9667 3186586 PK04_094140 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H01 compound treatment 4730000.0 -5610000.0 -4.83 4745600.0 -5260000.0 -4.36 4351480.0 -4837942.5 -4.06812740773489 -7.6522 -0.9975 3068116 PK04_094141 CCCN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H02 compound treatment 6478160.0 -3860000.0 -3.32 8155000.0 -1850000.0 -1.53 5466120.0 -3723302.5 -3.1308493119829 -4.6095 -0.9574 3000914 PK04_094142 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H03 mock treatment 1.071392E7 376000.0 0.32 1.028304E7 282000.0 0.23 9113280.0 -76142.5 -0.0640266789329253 0.2851 0.7047 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H04 mock treatment 1.1023E7 685000.0 0.59 1.000956E7 8830.0 0.01 9548120.0 358697.5 0.301621429117023 0.5188 0.7833 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H05 compound treatment 9981920.0 -356000.0 -0.31 9424520.0 -576000.0 -0.48 9279160.0 89737.5 0.0754584378073137 -0.4093 -0.7146 3068117 PK04_094143 CCCN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H06 compound treatment 7437160.0 -2900000.0 -2.5 4739120.0 -5260000.0 -4.36 7363440.0 -1825982.5 -1.53543152988988 -4.8479 -0.9221 3089723 PK04_094144 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H07 compound treatment 9852000.0 -486000.0 -0.42 6604440.0 -3400000.0 -2.82 8228160.0 -961262.5 -0.808306076865891 -2.3348 -0.7886 3186589 PK04_094145 CN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H08 compound treatment 9483040.0 -855000.0 -0.74 6212280.0 -3790000.0 -3.14 7844400.0 -1345022.5 -1.13100205227121 -2.8922 -0.8456 3089724 PK04_094146 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H09 compound treatment 1.026448E7 -73400.0 -0.06 8686920.0 -1310000.0 -1.09 8608760.0 -580662.5 -0.488267281162159 -0.9476 -0.7924 3186590 PK04_094147 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(C(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H10 compound treatment 1.000252E7 -335000.0 -0.29 8508960.0 -1490000.0 -1.24 8037800.0 -1151622.5 -0.9683759274969 -1.4402 -0.9015 3000917 PK04_094148 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H11 compound treatment 9115560.0 -1220000.0 -1.05 7300720.0 -2700000.0 -2.24 6679040.0 -2510382.5 -2.11092956399296 -3.1193 -0.959 3068119 PK04_094149 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H12 compound treatment 9697400.0 -640000.0 -0.55 7313280.0 -2690000.0 -2.23 5777280.0 -3412142.5 -2.86920119934188 -3.2619 -0.8876 3089768 PK04_094150 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H13 compound treatment 1.004148E7 -296000.0 -0.26 8406160.0 -1590000.0 -1.32 7831640.0 -1357782.5 -1.14173167663584 -1.5702 -0.8892 3186593 PK04_094151 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H14 compound treatment 1.075156E7 414000.0 0.36 1.0818E7 817000.0 0.68 9693760.0 504337.5 0.424087141692671 0.8418 0.9617 3089763 PK04_094152 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H15 compound treatment 9779240.0 -559000.0 -0.48 9177680.0 -823000.0 -0.68 7571600.0 -1617822.5 -1.36039402144614 -1.4572 -0.9129 3186594 PK04_094153 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H16 compound treatment 1.030336E7 -34500.0 -0.03 9669440.0 -331000.0 -0.27 8460880.0 -728542.5 -0.612616564159184 -0.5295 -0.7879 3089764 PK04_094154 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H17 compound treatment 1.086476E7 527000.0 0.45 1.009732E7 96600.0 0.08 9801560.0 612137.5 0.514733968221473 0.6052 0.8763 3068121 PK04_094155 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(C(=O)c5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H18 compound treatment 1.05986E7 261000.0 0.22 9921920.0 -78800.0 -0.07 8670240.0 -519182.5 -0.43657000013256 -0.1602 -0.3236 3000919 PK04_094156 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H19 mock treatment 1.126212E7 924000.0 0.8 1.050888E7 508000.0 0.42 9535040.0 345617.5 0.290622723263621 0.8704 0.9201 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H20 mock treatment 1.06096E7 272000.0 0.23 1.051484E7 514000.0 0.43 1.019412E7 1004697.5 0.844829684567918 0.869 0.8914 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H21 compound treatment 8865520.0 -1470000.0 -1.27 9429600.0 -571000.0 -0.47 8222440.0 -966982.5 -0.813115908477623 -1.4746 -0.9342 3068122 PK04_094157 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H22 compound treatment 5651600.0 -4690000.0 -4.03 6071360.0 -3930000.0 -3.26 4762960.0 -4426462.5 -3.72212224836502 -6.3595 -0.9963 3089766 PK04_094158 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H23 compound treatment 9031960.0 -1310000.0 -1.12 7817240.0 -2180000.0 -1.81 7797320.0 -1392102.5 -1.17059066630624 -2.3705 -0.9747 3068123 PK04_094159 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 H24 compound treatment 8082880.0 -2250000.0 -1.94 8777120.0 -1220000.0 -1.02 7159840.0 -2029582.5 -1.70663462711868 -2.6919 -0.9695 3089769 PK04_094160 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I01 compound treatment 6880560.0 -3460000.0 -2.98 7829600.0 -2170000.0 -1.8 7024760.0 -2164662.5 -1.82022065056497 -3.8087 -0.9702 3186651 PK04_094161 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I02 compound treatment 8603680.0 -1730000.0 -1.49 8879560.0 -1120000.0 -0.93 8362960.0 -826462.5 -0.694955499722267 -1.7999 -0.9519 3068124 PK04_094162 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I03 compound treatment 8978600.0 -1360000.0 -1.17 9438000.0 -563000.0 -0.47 7998440.0 -1190982.5 -1.00147295061539 -1.5231 -0.9465 3186652 PK04_094163 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I04 compound treatment 8257280.0 -2080000.0 -1.79 8472400.0 -1530000.0 -1.27 4452560.0 -4736862.5 -3.98313129247022 -4.0655 -0.894 3068125 PK04_094164 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I05 mock treatment 9949640.0 -388000.0 -0.33 9695920.0 -305000.0 -0.25 8848960.0 -340462.5 -0.286287988655495 -0.5042 -0.9935 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I06 mock treatment 1.002968E7 -308000.0 -0.27 9783960.0 -217000.0 -0.18 9184880.0 -4542.5 -0.00381969582103048 -0.2592 -0.8087 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I07 compound treatment 1.04832E7 145000.0 0.13 9305680.0 -695000.0 -0.58 9150440.0 -38982.5 -0.0327795910497128 -0.2796 -0.4732 3186653 PK04_094165 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I08 compound treatment 1.110388E7 766000.0 0.66 1.044656E7 446000.0 0.37 1.009372E7 904297.5 0.760405367466881 1.0332 0.9636 3068126 PK04_094166 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I09 compound treatment 1.052148E7 184000.0 0.16 1.01866E7 186000.0 0.15 1.003096E7 841537.5 0.707631760482209 0.5888 0.7943 3186654 PK04_094167 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I10 compound treatment 1.07152E7 377000.0 0.32 1.009864E7 97900.0 0.08 9570680.0 381257.5 0.320591674075185 0.4195 0.905 3068572 PK04_094168 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I11 compound treatment 1.102756E7 690000.0 0.59 1.033304E7 332000.0 0.28 9927360.0 737937.5 0.62051662849349 0.8601 0.9537 3186655 PK04_094169 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I12 compound treatment 9428320.0 -910000.0 -0.78 5082920.0 -4920000.0 -4.08 5535520.0 -3653902.5 -3.07249226410629 -4.5813 -0.8867 3186656 PK04_094170 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I13 compound treatment 9519760.0 -818000.0 -0.7 8546400.0 -1450000.0 -1.21 7100440.0 -2088982.5 -1.75658287847128 -2.1172 -0.9434 3068573 PK04_094171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I14 compound treatment 1.021912E7 -119000.0 -0.1 9364760.0 -636000.0 -0.53 8761520.0 -427902.5 -0.359814505461418 -0.5713 -0.8834 3186657 PK04_094172 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I15 compound treatment 9866040.0 -472000.0 -0.41 9785160.0 -216000.0 -0.18 8292480.0 -896942.5 -0.754220697623473 -0.7731 -0.8835 3068574 PK04_094173 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I16 compound treatment 7743480.0 -2590000.0 -2.23 5927120.0 -4070000.0 -3.38 4656520.0 -4532902.5 -3.81162547856656 -5.4408 -0.9782 3186658 PK04_094174 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I17 compound treatment 9514880.0 -823000.0 -0.71 9238520.0 -762000.0 -0.63 7635400.0 -1554022.5 -1.30674589962297 -1.5285 -0.9463 3186659 PK04_094175 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I18 compound treatment 9506880.0 -831000.0 -0.72 8991080.0 -1010000.0 -0.84 7010720.0 -2178702.5 -1.83202660088468 -1.9542 -0.9142 3068575 PK04_094176 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I19 compound treatment 1.082204E7 484000.0 0.42 1.026172E7 261000.0 0.22 9574160.0 384737.5 0.323517935265539 0.5524 0.9687 3186660 PK04_094177 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I20 compound treatment 8456720.0 -1880000.0 -1.62 8073160.0 -1930000.0 -1.6 8058960.0 -1130462.5 -0.9505829140521 -2.4068 -0.9759 3068577 PK04_094178 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I21 mock treatment 1.00356E7 -302000.0 -0.26 1.008316E7 82400.0 0.07 9518720.0 329297.5 0.276899567336441 0.0492 0.1273 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I22 mock treatment 1.007676E7 -261000.0 -0.22 1.01466E7 146000.0 0.12 9095040.0 -94382.5 -0.0793643237927152 -0.1057 -0.3955 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I23 compound treatment 9268920.0 -1070000.0 -0.92 9248880.0 -752000.0 -0.62 9457200.0 267777.5 0.225168651120746 -0.7613 -0.6713 3186661 PK04_094179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 I24 compound treatment 5664080.0 -4670000.0 -4.02 7283600.0 -2720000.0 -2.25 6811600.0 -2377822.5 -1.99946255727072 -4.7781 -0.9507 3186662 PK04_094180 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J01 compound treatment 8198000.0 -2140000.0 -1.84 7474640.0 -2530000.0 -2.1 7450800.0 -1738622.5 -1.46197228345615 -3.1172 -0.9897 3068611 PK04_094181 CN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J02 compound treatment 6305600.0 -4030000.0 -3.47 5788880.0 -4210000.0 -3.49 4534120.0 -4655302.5 -3.91454914802041 -6.2809 -0.9984 3089770 PK04_094182 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J03 compound treatment 8309520.0 -2030000.0 -1.75 8529840.0 -1470000.0 -1.22 7085320.0 -2104102.5 -1.76929697881558 -2.7339 -0.9874 3068612 PK04_094183 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J04 compound treatment 8999480.0 -1340000.0 -1.15 8546800.0 -1450000.0 -1.21 7960400.0 -1229022.5 -1.03346001259272 -1.9581 -0.998 3001007 PK04_094184 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J05 mock treatment 1.037332E7 35400.0 0.03 1.036884E7 368000.0 0.31 8634480.0 -554942.5 -0.466639856502412 -0.0755 -0.1352 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J06 mock treatment 1.020812E7 -130000.0 -0.11 1.00466E7 45900.0 0.04 9135320.0 -54102.5 -0.0454936913940124 -0.0688 -0.5439 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J07 compound treatment 7096720.0 -3240000.0 -2.79 5980040.0 -4020000.0 -3.34 6145680.0 -3043742.5 -2.55942113539744 -5.0139 -0.9937 3186665 PK04_094185 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J08 compound treatment 1.057076E7 233000.0 0.2 9338400.0 -662000.0 -0.55 8847000.0 -342422.5 -0.287936112774201 -0.3677 -0.5641 3089771 PK04_094186 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J09 compound treatment 9631080.0 -707000.0 -0.61 7290560.0 -2710000.0 -2.25 7505800.0 -1683622.5 -1.41572390257411 -2.4666 -0.905 3186666 PK04_094187 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J10 compound treatment 1.031132E7 -26600.0 -0.02 9546280.0 -454000.0 -0.38 8659680.0 -529742.5 -0.445449689261912 -0.488 -0.8357 3089776 PK04_094188 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J11 compound treatment 1.026232E7 -75600.0 -0.07 9561520.0 -439000.0 -0.36 9524840.0 335417.5 0.282045750809134 -0.0851 -0.1828 3068615 PK04_094189 CCCN1C(=O)[C@]2(COC(=N2)c3ccc(OCCCO)cc3)Cc4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J12 compound treatment 9186880.0 -1150000.0 -0.99 8921800.0 -1080000.0 -0.9 7783640.0 -1405782.5 -1.18209389995108 -1.7712 -0.9933 3001011 PK04_094190 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J13 compound treatment 1.026484E7 -73000.0 -0.06 8145640.0 -1860000.0 -1.54 6231880.0 -2957542.5 -2.48693730936049 -2.3606 -0.807 3068616 PK04_094191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J14 compound treatment 1.068768E7 350000.0 0.3 9562560.0 -438000.0 -0.36 8678840.0 -510582.5 -0.429338435121914 -0.2839 -0.445 3089772 PK04_094192 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J15 compound treatment 8687040.0 -1650000.0 -1.42 7051160.0 -2950000.0 -2.45 5010680.0 -4178742.5 -3.5138195408723 -4.2617 -0.9446 3068617 PK04_094193 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J16 compound treatment 1.018688E7 -151000.0 -0.13 9303320.0 -697000.0 -0.58 8496840.0 -692582.5 -0.582378531858853 -0.7453 -0.8967 3089773 PK04_094194 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J17 compound treatment 9960440.0 -377000.0 -0.32 9350960.0 -650000.0 -0.54 8187080.0 -1002342.5 -0.842849412986514 -0.9854 -0.9368 3186732 PK04_094195 CN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J18 compound treatment 9163920.0 -1170000.0 -1.01 8671720.0 -1330000.0 -1.1 7507760.0 -1681662.5 -1.4140757784554 -2.0363 -0.9894 3089774 PK04_094196 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J19 compound treatment 9575560.0 -762000.0 -0.66 9553400.0 -447000.0 -0.37 7162320.0 -2027102.5 -1.70454924558072 -1.5772 -0.8462 3186733 PK04_094197 CCCN1C(=O)[C@@]2(Cc3ccccc13)N=C(O[C@H]2c4ccccc4)c5ccc(OCCCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J20 compound treatment 9306840.0 -1030000.0 -0.89 8980040.0 -1020000.0 -0.85 7789240.0 -1400182.5 -1.17738497389763 -1.6809 -0.9887 3089775 PK04_094198 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J21 mock treatment 9636520.0 -701000.0 -0.6 9256440.0 -744000.0 -0.62 1.00946E7 905177.5 0.761145341560994 -0.2655 -0.2307 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J22 mock treatment 9732280.0 -606000.0 -0.52 9409240.0 -591000.0 -0.49 9240000.0 50577.5 0.0425295906192997 -0.5597 -0.7804 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J23 compound treatment 9183080.0 -1150000.0 -0.99 8787480.0 -1210000.0 -1.01 9003520.0 -185902.5 -0.156321629580433 -1.2451 -0.875 3068619 PK04_094199 COC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 J24 compound treatment 5317480.0 -5020000.0 -4.32 5520120.0 -4480000.0 -3.72 5581080.0 -3608342.5 -3.03418178714291 -6.3924 -0.99 3089828 PK04_094200 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K01 compound treatment 4187800.0 -6150000.0 -5.29 4011160.0 -5990000.0 -4.97 4282520.0 -4906902.5 -4.12611446856445 -8.3068 -0.9948 3068620 PK04_094201 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K02 compound treatment 5920760.0 -4420000.0 -3.8 6091800.0 -3910000.0 -3.24 4986480.0 -4202942.5 -3.5341688284604 -6.1075 -0.9979 3186736 PK04_094202 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K03 compound treatment 9543120.0 -795000.0 -0.68 6527840.0 -3470000.0 -2.88 5574360.0 -3615062.5 -3.03983249840704 -3.8133 -0.8986 3186737 PK04_094203 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K04 compound treatment 1.061904E7 281000.0 0.24 9924880.0 -75800.0 -0.06 8937640.0 -251782.5 -0.211718781080596 -0.0189 -0.0576 3068660 PK04_094204 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K05 compound treatment 1.050644E7 169000.0 0.15 1.019152E7 191000.0 0.16 9077200.0 -112222.5 -0.0943656167915449 0.1207 0.5145 3186738 PK04_094205 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K06 compound treatment 1.10144E7 677000.0 0.58 1.04848E7 484000.0 0.4 9049920.0 -139502.5 -0.117304813709038 0.5003 0.6978 3068661 PK04_094206 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K07 mock treatment 1.09488E7 611000.0 0.53 1.017E7 169000.0 0.14 9327280.0 137857.5 0.115921566680838 0.4516 0.8115 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K08 mock treatment 1.093396E7 596000.0 0.51 1.03528E7 352000.0 0.29 9342520.0 153097.5 0.128736572583426 0.5391 0.8923 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K09 compound treatment 7788520.0 -2550000.0 -2.19 7837200.0 -2160000.0 -1.79 6921800.0 -2267622.5 -1.90679761957615 -3.4039 -0.9964 3186739 PK04_094207 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K10 compound treatment 1.0963E7 625000.0 0.54 9795720.0 -205000.0 -0.17 9673720.0 484297.5 0.40723591345856 0.4475 0.6432 3186740 PK04_094208 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K11 compound treatment 6117880.0 -4220000.0 -3.63 5558080.0 -4440000.0 -3.69 5285840.0 -3903582.5 -3.28244309571771 -6.1198 -0.9987 3068664 PK04_094209 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K12 compound treatment 1.056312E7 225000.0 0.19 9882240.0 -118000.0 -0.1 9261280.0 71857.5 0.060423509622388 0.0901 0.3992 3186741 PK04_094210 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K13 compound treatment 1.130792E7 970000.0 0.83 9747680.0 -253000.0 -0.21 9519480.0 330057.5 0.277538635872266 0.521 0.5761 3068666 PK04_094211 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K14 compound treatment 7148840.0 -3190000.0 -2.74 6718800.0 -3280000.0 -2.72 6017560.0 -3171862.5 -2.66715463646302 -4.6964 -0.9999 3186742 PK04_094212 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K15 mock treatment 1.065904E7 321000.0 0.28 9877080.0 -124000.0 -0.1 9328000.0 138577.5 0.116527000030567 0.1676 0.5288 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K16 mock treatment 1.071128E7 373000.0 0.32 1.066932E7 669000.0 0.55 9298840.0 109417.5 0.0920069493665607 0.5589 0.863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K17 compound treatment 1.03666E7 28700.0 0.02 9201200.0 -800000.0 -0.66 8666920.0 -522502.5 -0.439361720578531 -0.6223 -0.7818 3186743 PK04_094213 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K18 compound treatment 8883080.0 -1450000.0 -1.25 8733200.0 -1270000.0 -1.05 7675920.0 -1513502.5 -1.27267345610769 -2.0647 -0.9965 3068667 PK04_094214 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K19 compound treatment 1.00108E7 -327000.0 -0.28 9492840.0 -508000.0 -0.42 9420280.0 230857.5 0.19412337435411 -0.2937 -0.5413 3186744 PK04_094215 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K20 compound treatment 8381080.0 -1960000.0 -1.68 9310160.0 -691000.0 -0.57 7941480.0 -1247942.5 -1.04936945561614 -1.9089 -0.9243 3186745 PK04_094216 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K21 compound treatment 8522840.0 -1820000.0 -1.56 8887880.0 -1110000.0 -0.92 7916160.0 -1273262.5 -1.07066052841493 -2.053 -0.9745 3068668 PK04_094217 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K22 compound treatment 9063440.0 -1270000.0 -1.1 9726640.0 -274000.0 -0.23 8206600.0 -982822.5 -0.826435442171651 -1.2417 -0.892 3186746 PK04_094218 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K23 mock treatment 9406920.0 -931000.0 -0.8 9555560.0 -445000.0 -0.37 8726880.0 -462542.5 -0.388942576620581 -0.9004 -0.9338 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 K24 mock treatment 8742680.0 -1600000.0 -1.37 9093560.0 -907000.0 -0.75 8808440.0 -380982.5 -0.320360432170775 -1.4121 -0.8836 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L01 compound treatment 9483600.0 -854000.0 -0.74 9384000.0 -617000.0 -0.51 8233680.0 -955742.5 -0.803664421184638 -1.1839 -0.9838 3068669 PK04_094219 CCOC(=O)N1C(N=C(N1C(=O)OCC)c2ccc(OCCCO)cc2)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L02 compound treatment 6386160.0 -3950000.0 -3.4 4900160.0 -5100000.0 -4.23 4769320.0 -4420102.5 -3.71677425377575 -6.5524 -0.9959 3001020 PK04_094220 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L03 compound treatment 8896640.0 -1440000.0 -1.24 9514000.0 -487000.0 -0.4 8844240.0 -345182.5 -0.290256940614827 -1.1168 -0.8357 3068670 PK04_094221 COCCCNC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L04 compound treatment 4528440.0 -5810000.0 -5.0 4372640.0 -5630000.0 -4.67 4666560.0 -4522862.5 -3.80318304685646 -7.778 -0.9937 3089829 PK04_094222 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L05 compound treatment 1.073164E7 394000.0 0.34 1.007632E7 75600.0 0.06 9192920.0 3497.5 0.00294097658427168 0.2336 0.6777 3186813 PK04_094223 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L06 compound treatment 9028760.0 -1310000.0 -1.13 8518160.0 -1480000.0 -1.23 8245840.0 -943582.5 -0.793439324611445 -1.8187 -0.9846 3001022 PK04_094224 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L07 mock treatment 1.090276E7 565000.0 0.49 1.024264E7 242000.0 0.2 9506320.0 316897.5 0.266472659646671 0.5504 0.9335 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L08 mock treatment 1.065584E7 318000.0 0.27 1.023116E7 230000.0 0.19 9660000.0 470577.5 0.395699044627621 0.4968 0.9597 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L09 compound treatment 1.091544E7 578000.0 0.5 9791320.0 -209000.0 -0.17 9161600.0 -27822.5 -0.0233953741289203 0.1732 0.3286 3067926 PK04_094225 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L10 compound treatment 9274720.0 -1060000.0 -0.91 9388840.0 -612000.0 -0.51 8307200.0 -882222.5 -0.741842949140134 -1.2496 -0.9743 3089768 PK04_094226 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L11 compound treatment 1.098964E7 652000.0 0.56 1.03718E7 371000.0 0.31 9618680.0 429257.5 0.360953897390421 0.71 0.9664 3186815 PK04_094227 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L12 compound treatment 8066200.0 -2270000.0 -1.96 8242800.0 -1760000.0 -1.46 7865920.0 -1323502.5 -1.11290632215154 -2.6133 -0.9747 3089830 PK04_094228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L13 compound treatment 1.095028E7 612000.0 0.53 1.118968E7 1190000.0 0.99 9426960.0 237537.5 0.199740450432147 0.9891 0.8707 3067927 PK04_094229 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L14 compound treatment 9494000.0 -844000.0 -0.73 1.019416E7 193000.0 0.16 8840600.0 -348822.5 -0.293317742549566 -0.496 -0.6204 3089831 PK04_094230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L15 mock treatment 1.048416E7 146000.0 0.13 1.064328E7 643000.0 0.53 9555240.0 365817.5 0.307608492242117 0.558 0.8883 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L16 mock treatment 1.06882E7 350000.0 0.3 1.038608E7 385000.0 0.32 9562600.0 373177.5 0.313797366483787 0.5398 0.9997 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L17 compound treatment 6464280.0 -3870000.0 -3.33 6825840.0 -3170000.0 -2.63 5378400.0 -3811022.5 -3.2046112750915 -5.2956 -0.9951 3067928 PK04_094231 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L18 compound treatment 9152680.0 -1190000.0 -1.02 8937480.0 -1060000.0 -0.88 8293800.0 -895622.5 -0.753110736482304 -1.533 -0.9925 3001180 PK04_094232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L19 compound treatment 1.035704E7 19200.0 0.02 1.018872E7 188000.0 0.16 9488720.0 299297.5 0.251673177764418 0.2449 0.8258 3067929 PK04_094233 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L20 compound treatment 9614160.0 -724000.0 -0.62 8745320.0 -1260000.0 -1.04 7723080.0 -1466342.5 -1.23301757170047 -1.6728 -0.9669 3001092 PK04_094234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L21 compound treatment 9763840.0 -574000.0 -0.49 9458400.0 -542000.0 -0.45 8831320.0 -358102.5 -0.301121105723845 -0.7188 -0.9808 3067930 PK04_094235 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L22 compound treatment 8269760.0 -2070000.0 -1.78 8178800.0 -1820000.0 -1.51 7573920.0 -1615502.5 -1.35844318065257 -2.6845 -0.9937 3001093 PK04_094236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L23 mock treatment 9501320.0 -837000.0 -0.72 9604760.0 -396000.0 -0.33 8715080.0 -474342.5 -0.39886495651891 -0.8356 -0.9429 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 L24 mock treatment 9149680.0 -1190000.0 -1.02 9107680.0 -893000.0 -0.74 8127400.0 -1062022.5 -0.893033110641792 -1.5337 -0.9917 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M01 compound treatment 3625760.0 -6710000.0 -5.78 3444080.0 -6560000.0 -5.44 2555640.0 -6633782.5 -5.57821272270228 -9.6961 -0.9997 3067931 PK04_094237 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M02 compound treatment 8972880.0 -1360000.0 -1.17 8337040.0 -1660000.0 -1.38 7797280.0 -1392142.5 -1.17062430149233 -2.1509 -0.9969 3186821 PK04_094238 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M03 compound treatment 8040880.0 -2300000.0 -1.98 6800360.0 -3200000.0 -2.65 6454720.0 -2734702.5 -2.2995556876195 -4.0018 -0.9929 3067933 PK04_094239 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M04 compound treatment 1.032336E7 -14500.0 -0.01 9872120.0 -129000.0 -0.11 8868160.0 -321262.5 -0.270143099329401 -0.2248 -0.7732 3186822 PK04_094240 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCCN3CCOCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M05 compound treatment 9731640.0 -606000.0 -0.52 9952720.0 -48000.0 -0.04 8617480.0 -571942.5 -0.480934810593225 -0.6019 -0.8469 3067934 PK04_094241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M06 compound treatment 1.099176E7 654000.0 0.56 1.01428E7 142000.0 0.12 9607640.0 418217.5 0.351670586027917 0.596 0.8843 3186823 PK04_094242 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M07 compound treatment 9607040.0 -731000.0 -0.63 9161000.0 -840000.0 -0.7 8189880.0 -999542.5 -0.840494949959792 -1.2506 -0.9926 3186824 PK04_094243 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M08 compound treatment 6319360.0 -4020000.0 -3.46 5910640.0 -4090000.0 -3.39 5373760.0 -3815662.5 -3.20851295667863 -5.8082 -0.9995 3186825 PK04_094244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M09 mock treatment 1.077044E7 433000.0 0.37 9735680.0 -265000.0 -0.22 9045640.0 -143782.5 -0.120903778621313 0.0182 0.0405 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M10 mock treatment 9977720.0 -360000.0 -0.31 9890560.0 -110000.0 -0.09 9883400.0 693977.5 0.583551558973952 0.1052 0.1577 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M11 compound treatment 7112280.0 -3230000.0 -2.78 7102560.0 -2900000.0 -2.4 6118920.0 -3070502.5 -2.58192307489568 -4.4815 -0.9983 3067981 PK04_094245 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M12 compound treatment 1.076264E7 425000.0 0.37 9743520.0 -257000.0 -0.21 9734920.0 545497.5 0.458697748185486 0.3527 0.5651 3186826 PK04_094246 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M13 mock treatment 1.133144E7 994000.0 0.86 1.109792E7 1100000.0 0.91 1.028064E7 1091217.5 0.917582592093632 1.549 0.9995 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M14 mock treatment 1.100656E7 669000.0 0.58 1.073024E7 730000.0 0.61 9338120.0 148697.5 0.125036702112863 0.7539 0.8927 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M15 compound treatment 9108880.0 -1230000.0 -1.06 8270680.0 -1730000.0 -1.44 3789440.0 -5399982.5 -4.54073540757021 -4.0609 -0.8325 3067982 PK04_094247 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M16 compound treatment 8238960.0 -2100000.0 -1.81 9680280.0 -320000.0 -0.27 8015640.0 -1173782.5 -0.987009820594101 -1.7663 -0.851 3186827 PK04_094248 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M17 compound treatment 8978840.0 -1360000.0 -1.17 8937600.0 -1060000.0 -0.88 7614160.0 -1575262.5 -1.32460618343996 -1.9492 -0.987 3067983 PK04_094249 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M18 compound treatment 9338560.0 -999000.0 -0.86 8427960.0 -1570000.0 -1.3 8091880.0 -1097542.5 -0.922901155895067 -1.7827 -0.9823 3186828 PK04_094250 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M19 compound treatment 9393520.0 -944000.0 -0.81 8968320.0 -1030000.0 -0.86 8924680.0 -264742.5 -0.22261658137571 -1.0922 -0.9091 3186829 PK04_094251 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M20 compound treatment 1.030788E7 -30000.0 -0.03 9365600.0 -635000.0 -0.53 9436720.0 247297.5 0.207947435839578 -0.199 -0.351 3067984 PK04_094252 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M21 compound treatment 9928520.0 -409000.0 -0.35 9551600.0 -449000.0 -0.37 8657560.0 -531862.5 -0.447232354125002 -0.6767 -0.9946 3186907 PK04_094253 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M22 compound treatment 8661360.0 -1680000.0 -1.44 7842160.0 -2160000.0 -1.79 7239880.0 -1949542.5 -1.63933061974052 -2.8134 -0.9962 3067985 PK04_094254 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M23 compound treatment 5804160.0 -4530000.0 -3.9 6254000.0 -3750000.0 -3.11 5368360.0 -3821062.5 -3.2130537068016 -5.9023 -0.9947 3186908 PK04_094255 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 M24 compound treatment 3718520.0 -6620000.0 -5.7 3653400.0 -6350000.0 -5.27 3491600.0 -5697822.5 -4.79118300324126 -9.0954 -0.9975 3186909 PK04_094256 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N01 compound treatment 8499440.0 -1840000.0 -1.58 8471720.0 -1530000.0 -1.27 8167360.0 -1022062.5 -0.859431559731857 -2.142 -0.9725 3067986 PK04_094257 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N02 compound treatment 8396600.0 -1940000.0 -1.67 7984960.0 -2020000.0 -1.67 8083560.0 -1105862.5 -0.929897274603041 -2.4669 -0.9712 3186910 PK04_094258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N03 compound treatment 9476880.0 -861000.0 -0.74 9064840.0 -936000.0 -0.78 8700040.0 -489382.5 -0.411511786491017 -1.1137 -0.9689 3067987 PK04_094259 CN(C)C(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N04 compound treatment 1.011704E7 -221000.0 -0.19 1.004272E7 42000.0 0.03 8793640.0 -395782.5 -0.332805451026306 -0.2818 -0.7322 3186911 PK04_094260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N05 compound treatment 1.05286E7 191000.0 0.16 1.020604E7 205000.0 0.17 8249640.0 -939782.5 -0.790243981932322 -0.2631 -0.319 3414052 PK04_094261 COC(=O)[C@@H]1N=C(O[C@@H]1C)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N06 compound treatment 1.08434E7 506000.0 0.44 1.002404E7 23300.0 0.02 9139920.0 -49502.5 -0.0416256449929689 0.2383 0.5448 3186912 PK04_094262 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N07 compound treatment 9849480.0 -488000.0 -0.42 9321600.0 -679000.0 -0.56 9767880.0 578457.5 0.486413141528616 -0.2871 -0.3359 3186913 PK04_094263 OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N08 compound treatment 1.009492E7 -243000.0 -0.21 1.043792E7 437000.0 0.36 9407680.0 218257.5 0.18352829073386 0.1946 0.4258 1952953 PK04_094264 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N09 mock treatment 1.00222E7 -316000.0 -0.27 1.006836E7 67600.0 0.06 9355040.0 165617.5 0.139264385831484 -0.0441 -0.1419 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N10 mock treatment 1.052872E7 191000.0 0.16 9807000.0 -194000.0 -0.16 9332000.0 142577.5 0.11989051864017 0.0713 0.2749 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N11 compound treatment 9880640.0 -457000.0 -0.39 1.00292E7 28500.0 0.02 9519640.0 330217.5 0.27767317661665 -0.0532 -0.1104 3068027 PK04_094265 CC(=O)OC[C@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N12 compound treatment 8722480.0 -1620000.0 -1.39 9005960.0 -995000.0 -0.83 7773040.0 -1416382.5 -1.19100722426653 -1.9667 -0.9794 3186914 PK04_094266 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N13 mock treatment 1.02664E7 -71500.0 -0.06 9893120.0 -108000.0 -0.09 8995040.0 -194382.5 -0.163452289032792 -0.1814 -0.925 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N14 mock treatment 1.000828E7 -330000.0 -0.28 1.040764E7 407000.0 0.34 9174560.0 -14862.5 -0.0124975738338064 0.0239 0.0542 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N15 compound treatment 9640160.0 -698000.0 -0.6 9972160.0 -28600.0 -0.02 9089720.0 -99702.5 -0.0838378035434873 -0.4088 -0.6737 3068028 PK04_094267 CC(=O)OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N16 compound treatment 8160520.0 -2180000.0 -1.87 7053160.0 -2950000.0 -2.45 7337720.0 -1851702.5 -1.55705895454963 -3.3926 -0.9828 3186915 PK04_094268 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N17 compound treatment 9661200.0 -677000.0 -0.58 9427760.0 -573000.0 -0.48 8971800.0 -217622.5 -0.182994332154586 -0.7163 -0.9259 3068029 PK04_094269 CC(=O)OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N18 compound treatment 8590640.0 -1750000.0 -1.5 6817520.0 -3180000.0 -2.64 6503640.0 -2685782.5 -2.25841985502406 -3.6967 -0.9764 1952947 PK04_094270 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@@H](Cc5ccccc5)C/C=C/C[C@H](Cc6ccccc6)C(=O)O[C@@H]14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N19 compound treatment 9046600.0 -1290000.0 -1.11 9110560.0 -890000.0 -0.74 9026400.0 -163022.5 -0.137082303133504 -1.1471 -0.8552 3068030 PK04_094271 OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N20 compound treatment 5464920.0 -4870000.0 -4.19 4757920.0 -5240000.0 -4.35 5082160.0 -4107262.5 -3.4537134633187 -6.9264 -0.9953 3186916 PK04_094272 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N21 compound treatment 9633720.0 -704000.0 -0.61 9738240.0 -262000.0 -0.22 8819520.0 -369902.5 -0.311043485622174 -0.6552 -0.9162 3068031 PK04_094273 CC(=O)OC[C@@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N22 compound treatment 5325520.0 -5010000.0 -4.31 4685720.0 -5320000.0 -4.41 4787920.0 -4401502.5 -3.7011338922411 -7.1731 -0.9971 1952944 PK04_094274 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N23 compound treatment 8422160.0 -1920000.0 -1.65 8161160.0 -1840000.0 -1.53 8192320.0 -997102.5 -0.838443203607934 -2.317 -0.9663 3186917 PK04_094275 CC(=O)OC[C@H](C=C)N(Cc1ccc(cc1)[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 N24 compound treatment 8437200.0 -1900000.0 -1.64 9939640.0 -61100.0 -0.05 7787800.0 -1401622.5 -1.17859584059709 -1.6541 -0.8202 3413982 PK04_094276 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O01 compound treatment 3161800.0 -7180000.0 -6.18 3197920.0 -6800000.0 -5.64 3336400.0 -5853022.5 -4.92168752529386 -9.6655 -0.9958 3068032 PK04_094277 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O02 compound treatment 4690880.0 -5650000.0 -4.86 4731840.0 -5270000.0 -4.37 4367560.0 -4821862.5 -4.05460606292428 -7.6704 -0.9972 3186919 PK04_094278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O03 compound treatment 9947040.0 -391000.0 -0.34 9323720.0 -677000.0 -0.56 8101920.0 -1087502.5 -0.914458724184963 -1.0464 -0.9305 3068033 PK04_094279 NC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O04 compound treatment 9494400.0 -843000.0 -0.73 8861640.0 -1140000.0 -0.94 9294520.0 105097.5 0.0883743492681894 -0.9137 -0.7647 3186920 PK04_094280 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O05 compound treatment 5220560.0 -5120000.0 -4.4 3581680.0 -6420000.0 -5.33 2917320.0 -6272102.5 -5.27408337002197 -8.6622 -0.9964 3068035 PK04_094281 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O06 compound treatment 9919120.0 -419000.0 -0.36 8799400.0 -1200000.0 -1.0 8187440.0 -1001982.5 -0.84254669631165 -1.2699 -0.938 3186921 PK04_094282 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O07 compound treatment 6427880.0 -3910000.0 -3.37 5818440.0 -4180000.0 -3.47 5232760.0 -3956662.5 -3.32707698766714 -5.8668 -0.9998 3186922 PK04_094283 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O08 compound treatment 9476840.0 -861000.0 -0.74 8841320.0 -1160000.0 -0.96 8533400.0 -656022.5 -0.551635971767081 -1.3016 -0.976 3068037 PK04_094284 CN(C)C(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O09 compound treatment 7289160.0 -3050000.0 -2.62 7563320.0 -2440000.0 -2.02 6899800.0 -2289622.5 -1.92529697192897 -3.7939 -0.9902 3186923 PK04_094285 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O10 compound treatment 8482760.0 -1860000.0 -1.6 4222200.0 -5780000.0 -4.79 4275560.0 -4913862.5 -4.13196699094515 -6.075 -0.9308 3068038 PK04_094286 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O11 mock treatment 1.094636E7 608000.0 0.52 9857920.0 -143000.0 -0.12 9706680.0 517257.5 0.434951306801689 0.4851 0.702 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O12 mock treatment 1.043236E7 94500.0 0.08 1.077888E7 778000.0 0.65 9401600.0 212177.5 0.178415742447263 0.5227 0.7747 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O13 compound treatment 1.014104E7 -197000.0 -0.17 9846520.0 -154000.0 -0.13 9146520.0 -42902.5 -0.0360758392871238 -0.1925 -0.894 3186924 PK04_094287 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O14 compound treatment 8613480.0 -1720000.0 -1.48 8923880.0 -1080000.0 -0.89 8271240.0 -918182.5 -0.772080981440466 -1.8184 -0.9588 3186925 PK04_094288 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O15 compound treatment 1.019872E7 -139000.0 -0.12 9892840.0 -108000.0 -0.09 9463800.0 274377.5 0.230718456826591 0.0124 0.0451 3187013 PK04_094289 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O16 compound treatment 1.010596E7 -232000.0 -0.2 8305560.0 -1700000.0 -1.41 8603360.0 -586062.5 -0.492808031285123 -1.2117 -0.8059 3068077 PK04_094290 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O17 compound treatment 1.041896E7 81100.0 0.07 8855520.0 -1150000.0 -0.95 8137800.0 -1051622.5 -0.884287962256824 -1.0188 -0.7838 3187014 PK04_094291 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O18 compound treatment 8744800.0 -1590000.0 -1.37 6430800.0 -3570000.0 -2.96 5805360.0 -3384062.5 -2.84558929870246 -4.1443 -0.9571 3187015 PK04_094292 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O19 compound treatment 9707080.0 -631000.0 -0.54 8945920.0 -1050000.0 -0.88 8847080.0 -342342.5 -0.287868842402009 -0.9848 -0.9211 3068081 PK04_094293 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O20 compound treatment 8802920.0 -1530000.0 -1.32 6492640.0 -3510000.0 -2.91 7292280.0 -1897142.5 -1.59526852595472 -3.3639 -0.9417 3187016 PK04_094294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O21 compound treatment 8740720.0 -1600000.0 -1.37 8531840.0 -1470000.0 -1.22 8451840.0 -737582.5 -0.620218116216887 -1.8552 -0.9569 3187017 PK04_094295 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O22 compound treatment 7759960.0 -2580000.0 -2.22 7335320.0 -2670000.0 -2.21 6924160.0 -2265262.5 -1.90481314359649 -3.6573 -0.9976 3068083 PK04_094296 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O23 compound treatment 4997160.0 -5340000.0 -4.6 4929440.0 -5070000.0 -4.21 4914000.0 -4275422.5 -3.59511578566641 -7.1583 -0.9951 3187018 PK04_094297 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 O24 compound treatment 3786120.0 -6550000.0 -5.64 3810920.0 -6190000.0 -5.13 3252560.0 -5936862.5 -4.99218687535114 -9.1024 -0.9986 3068084 PK04_094298 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P01 compound treatment 5500120.0 -4840000.0 -4.16 5146720.0 -4850000.0 -4.03 5759600.0 -3429822.5 -2.88406795159632 -6.3938 -0.9881 3187019 PK04_094299 CC(=O)OC[C@H](C=C)N(Cc1ccccc1[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P02 compound treatment 8223680.0 -2110000.0 -1.82 7500560.0 -2500000.0 -2.07 6757960.0 -2431462.5 -2.0445673418255 -3.4284 -0.9984 3413984 PK04_094300 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P03 compound treatment 8443480.0 -1890000.0 -1.63 8425640.0 -1580000.0 -1.31 8103040.0 -1086382.5 -0.913516938974274 -2.2231 -0.9749 3068086 PK04_094301 COc1ccc(CN([C@H](CO)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P04 compound treatment 8526200.0 -1810000.0 -1.56 8511600.0 -1490000.0 -1.24 8294960.0 -894462.5 -0.752135316085519 -2.0477 -0.9628 3413986 PK04_094302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P05 compound treatment 9568360.0 -770000.0 -0.66 1.146868E7 1470000.0 1.22 8054800.0 -1134622.5 -0.954080973406087 -0.2301 -0.1367 3068087 PK04_094303 COc1cc(CN([C@@H](COC(=O)C)C=C)S(=O)(=O)c2ccc(Br)cc2)ccc1OC(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P06 compound treatment 5375120.0 -4960000.0 -4.27 5068760.0 -4930000.0 -4.09 4599840.0 -4589582.5 -3.85928653726464 -7.0563 -0.9991 1952975 PK04_094304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P07 compound treatment 8737520.0 -1600000.0 -1.38 9339280.0 -661000.0 -0.55 8275040.0 -914382.5 -0.768885638761343 -1.5559 -0.9316 3068088 PK04_094305 OCCCNS(=O)(=O)c1ccc(Br)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P08 compound treatment 7863480.0 -2470000.0 -2.13 6155240.0 -3850000.0 -3.19 5563920.0 -3625502.5 -3.04861128197811 -4.8314 -0.9861 3413993 PK04_094306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P09 compound treatment 9458320.0 -880000.0 -0.76 1.056144E7 561000.0 0.47 8172880.0 -1016542.5 -0.854789904050605 -0.662 -0.5369 3068089 PK04_094307 CC[Si](CC)(CC)OC[C@@H](C=C)N(Cc1ccc(OC(=O)C)c(OC)c1)S(=O)(=O)c2ccc(Br)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P10 compound treatment 7847000.0 -2490000.0 -2.14 6047480.0 -3950000.0 -3.28 5490760.0 -3698662.5 -3.11013003734775 -4.9267 -0.9849 1952969 PK04_094308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5ccccc5)C/C=C/C[C@@H](Cc6ccccc6)C(=O)O[C@@H]14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P11 mock treatment 1.24036E7 2070000.0 1.78 9113240.0 -887000.0 -0.74 7956400.0 -1233022.5 -1.03682353120232 0.0028 0.0013 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P12 mock treatment 8951960.0 -1390000.0 -1.19 9003520.0 -997000.0 -0.83 7757760.0 -1431662.5 -1.20385586535521 -1.8613 -0.987 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P13 compound treatment 8579800.0 -1760000.0 -1.51 8471560.0 -1530000.0 -1.27 8234280.0 -955142.5 -0.803159893393198 -2.0697 -0.971 3068090 PK04_094309 COc1cc(CO)ccc1OC(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P14 compound treatment 8546480.0 -1790000.0 -1.54 8302800.0 -1700000.0 -1.41 8644960.0 -544462.5 -0.457827437745252 -1.9677 -0.9204 3068091 PK04_094310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P15 compound treatment 8719440.0 -1620000.0 -1.39 6921280.0 -3080000.0 -2.55 7583920.0 -1605502.5 -1.35003438412856 -3.0585 -0.9535 3187025 PK04_094311 COc1ccc(CN(C2=CC[C@@]3(C(=O)N)C(=O)C(=C(Cl)C(=O)[C@]3(C2)C#N)Cl)S(=O)(=O)c4ccc(Br)cc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P16 compound treatment 9102800.0 -1240000.0 -1.06 8351320.0 -1650000.0 -1.37 8088760.0 -1100662.5 -0.925524700410557 -1.938 -0.9866 3187026 PK04_094312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P17 compound treatment 8733200.0 -1600000.0 -1.38 8774880.0 -1230000.0 -1.02 7505960.0 -1683462.5 -1.41558936182972 -2.2018 -0.9901 3068092 PK04_094313 CC(C)(C)OC(=O)N1[C@H](COC1(C)C)C=C(Br)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P18 compound treatment 8981680.0 -1360000.0 -1.17 8218080.0 -1780000.0 -1.48 8341880.0 -847542.5 -0.712681242794876 -1.9392 -0.9627 3187027 PK04_094314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P19 compound treatment 8181200.0 -2160000.0 -1.86 8068400.0 -1930000.0 -1.6 8088720.0 -1100702.5 -0.925558335596653 -2.5315 -0.9657 1003211 PK04_094315 CNS(=O)(=O)c1ccc(C)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P20 compound treatment 7032200.0 -3310000.0 -2.84 6791040.0 -3210000.0 -2.66 6679880.0 -2509542.5 -2.11022322508495 -4.3982 -0.9925 3187028 PK04_094316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P21 compound treatment 8100160.0 -2240000.0 -1.93 7658360.0 -2340000.0 -1.94 8145200.0 -1044222.5 -0.878065452829058 -2.7407 -0.9539 3068127 PK04_094317 COc1cc(COC(=O)C)ccc1OC(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P22 compound treatment 7937080.0 -2400000.0 -2.07 7187600.0 -2810000.0 -2.33 6609320.0 -2580102.5 -2.16955569335835 -3.7929 -0.9987 3187029 PK04_094318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P23 compound treatment 7663880.0 -2670000.0 -2.3 7339920.0 -2660000.0 -2.21 6965440.0 -2223982.5 -1.87010163154538 -3.6828 -0.9962 3068129 PK04_094319 OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2094 P24 compound treatment 7382400.0 -2960000.0 -2.54 7468440.0 -2530000.0 -2.1 7182880.0 -2006542.5 -1.68726075992736 -3.6555 -0.9866 3413981 PK04_094320 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A01 compound treatment 7043160.0 -2530000.0 -2.18 7318640.0 -1850000.0 -1.54 7088560.0 -2344465.0 -1.97141291426576 -3.285 -0.9901 3067957 PK04_095001 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A02 compound treatment 8084080.0 -1490000.0 -1.29 7831120.0 -1340000.0 -1.11 7964000.0 -1469025.0 -1.23527323136803 -2.0973 -0.9982 3187176 PK04_095002 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A03 compound treatment 4762160.0 -4820000.0 -4.14 4762520.0 -4410000.0 -3.66 8274520.0 -1158505.0 -0.974163281704548 -5.0669 -0.9027 3067577 PK04_095003 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A04 compound treatment 8663840.0 -914000.0 -0.79 8080600.0 -1090000.0 -0.9 9488760.0 55735.0 0.0468664274265566 -0.9495 -0.7913 3187436 PK04_095004 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A05 compound treatment 4801200.0 -4780000.0 -4.11 5068440.0 -4100000.0 -3.4 6019360.0 -3413665.0 -2.87048143861266 -5.9958 -0.9894 3186425 PK04_095005 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6I)c7ccc(cc7)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A06 compound treatment 8802240.0 -776000.0 -0.67 8775160.0 -396000.0 -0.33 8662480.0 -770545.0 -0.647935611759148 -0.9492 -0.9621 3187069 PK04_095006 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A07 compound treatment 8105640.0 -1470000.0 -1.27 8186240.0 -985000.0 -0.82 8281120.0 -1151905.0 -0.968613475998703 -1.7625 -0.9836 3187427 PK04_095007 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A08 compound treatment 4083080.0 -5490000.0 -4.73 4142240.0 -5030000.0 -4.17 4824880.0 -4608145.0 -3.87489536581232 -7.3761 -0.9966 3187515 PK04_095008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6)c7ccc(cc7)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A09 compound treatment 8436280.0 -1140000.0 -0.98 8863440.0 -308000.0 -0.26 8515600.0 -917425.0 -0.771444015103772 -1.1601 -0.9099 3187425 PK04_095009 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A10 compound treatment 9002000.0 -576000.0 -0.5 8776920.0 -394000.0 -0.33 9179200.0 -253825.0 -0.213436277770624 -0.5982 -0.948 3068592 PK04_095010 CCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A11 compound treatment 3729840.0 -5850000.0 -5.03 3807520.0 -5360000.0 -4.45 4194120.0 -5238905.0 -4.40528861536063 -8.0182 -0.9981 3187517 PK04_095011 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A12 compound treatment 8666040.0 -912000.0 -0.78 8453080.0 -718000.0 -0.6 8407240.0 -1025785.0 -0.862561734237919 -1.2951 -0.989 3187344 PK04_095012 COCCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A13 mock treatment 9198520.0 -379000.0 -0.33 8737200.0 -434000.0 -0.36 9010760.0 -422265.0 -0.355074046421009 -0.6014 -0.9991 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A14 mock treatment 9010040.0 -568000.0 -0.49 8679960.0 -491000.0 -0.41 9440560.0 7535.0 0.00633602818083977 -0.5138 -0.8074 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A15 compound treatment 7987640.0 -1590000.0 -1.37 8091720.0 -1080000.0 -0.9 8594080.0 -838945.0 -0.70545177998336 -1.7145 -0.9625 3186552 PK04_095013 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A16 compound treatment 9283480.0 -294000.0 -0.25 8775320.0 -396000.0 -0.33 8703640.0 -729385.0 -0.613325005266332 -0.69 -0.9319 3187439 PK04_095014 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A17 compound treatment 8489920.0 -1090000.0 -0.94 8286200.0 -885000.0 -0.73 8947400.0 -485625.0 -0.408352181197122 -1.2003 -0.9541 3187073 PK04_095015 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A18 compound treatment 8728000.0 -850000.0 -0.73 8805160.0 -366000.0 -0.3 8952200.0 -480825.0 -0.404315958865598 -0.8311 -0.9346 3187272 PK04_095016 COCCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A19 compound treatment 8710640.0 -867000.0 -0.75 9234040.0 62700.0 0.05 8711200.0 -721825.0 -0.606967955094182 -0.7513 -0.7798 3187508 PK04_095017 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NC3CC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A20 compound treatment 5201760.0 -4380000.0 -3.77 4933400.0 -4240000.0 -3.52 6259800.0 -3173225.0 -2.66830033498942 -5.7447 -0.9901 3186432 PK04_095018 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A21 compound treatment 8233640.0 -1340000.0 -1.16 7436160.0 -1740000.0 -1.44 7946480.0 -1486545.0 -1.2500054428781 -2.2207 -0.9958 3068646 PK04_095019 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A22 compound treatment 8309040.0 -1270000.0 -1.09 8266400.0 -905000.0 -0.75 8379760.0 -1053265.0 -0.885669107085892 -1.5752 -0.9883 3068651 PK04_095020 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A23 compound treatment 7834880.0 -1740000.0 -1.5 8020960.0 -1150000.0 -0.95 8211680.0 -1221345.0 -1.02700415906141 -2.01 -0.9789 3187585 PK04_095021 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 A24 compound treatment 6898040.0 -2680000.0 -2.31 7244640.0 -1930000.0 -1.6 8038760.0 -1394265.0 -1.17240906855455 -2.9312 -0.9639 3187430 PK04_095022 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B01 compound treatment 2338800.0 -7240000.0 -6.23 2365520.0 -6810000.0 -5.65 2672960.0 -6760065.0 -5.68440110740658 -10.1385 -0.999 3187519 PK04_095023 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B02 compound treatment 9026000.0 -552000.0 -0.47 8828880.0 -342000.0 -0.28 8821600.0 -611425.0 -0.514134841469138 -0.735 -0.9731 3186885 PK04_095024 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B03 compound treatment 8828280.0 -750000.0 -0.65 8866440.0 -305000.0 -0.25 9320880.0 -112145.0 -0.0943004486184838 -0.5729 -0.8193 3187435 PK04_095025 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B04 compound treatment 9060840.0 -517000.0 -0.44 9039360.0 -132000.0 -0.11 9209200.0 -223825.0 -0.188209888198601 -0.4287 -0.8655 3186491 PK04_095026 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B05 compound treatment 9758440.0 181000.0 0.16 9005600.0 -166000.0 -0.14 9423880.0 -9145.0 -0.007689844421205 0.0059 0.0286 3068539 PK04_095027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(F)cc(c4)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B06 compound treatment 8940640.0 -637000.0 -0.55 8138560.0 -1030000.0 -0.86 9164440.0 -268585.0 -0.22584766144006 -0.9416 -0.9037 3186559 PK04_095028 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B07 compound treatment 8724720.0 -853000.0 -0.73 8404960.0 -766000.0 -0.64 9220200.0 -212825.0 -0.178960212022193 -0.8943 -0.9055 3068561 PK04_095029 CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B08 compound treatment 3509160.0 -6070000.0 -5.22 3281000.0 -5890000.0 -4.89 3804680.0 -5628345.0 -4.73276078719158 -8.5691 -0.9991 3068322 PK04_095030 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B09 compound treatment 9457800.0 -120000.0 -0.1 9128120.0 -43200.0 -0.04 9186600.0 -246425.0 -0.207213768342859 -0.2 -0.8535 3187432 PK04_095031 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B10 compound treatment 9415360.0 -162000.0 -0.14 9435480.0 264000.0 0.22 9519560.0 86535.0 0.0727655207205002 0.0878 0.3253 3068145 PK04_095032 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(F)(F)F)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B11 compound treatment 9330880.0 -247000.0 -0.21 9003200.0 -168000.0 -0.14 9337480.0 -95545.0 -0.0803418463886311 -0.2496 -0.9363 3187265 PK04_095033 CC(C)N1[C@H]([C@H](C(=O)NCCCN(C)C)c2ccccc2C1=O)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B12 compound treatment 9599080.0 21300.0 0.02 9757120.0 586000.0 0.49 9442640.0 9615.0 0.00808505785783336 0.2958 0.6082 3186629 PK04_095034 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B13 mock treatment 1.036752E7 790000.0 0.68 9763400.0 592000.0 0.49 9813320.0 380295.0 0.319782327409749 0.8606 0.9589 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B14 mock treatment 9763360.0 186000.0 0.16 9424200.0 253000.0 0.21 9944840.0 511815.0 0.430374819293498 0.4618 0.915 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B15 compound treatment 9190040.0 -388000.0 -0.33 8988480.0 -183000.0 -0.15 9558600.0 125575.0 0.105593462350226 -0.2193 -0.5748 3187269 PK04_095035 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3CCCCC3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B16 compound treatment 9461680.0 -116000.0 -0.1 9175360.0 4040.0 0.0 9755440.0 322415.0 0.271112213128793 0.1008 0.3487 3186887 PK04_095036 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B17 compound treatment 9442800.0 -135000.0 -0.12 9082960.0 -88400.0 -0.07 9476040.0 43015.0 0.0361704382480189 -0.0885 -0.6231 3068417 PK04_095037 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B18 compound treatment 9350760.0 -227000.0 -0.2 9558240.0 387000.0 0.32 9944520.0 511495.0 0.430105737804729 0.3208 0.5617 3067610 PK04_095038 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(C7CC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B19 compound treatment 9749040.0 171000.0 0.15 9128400.0 -42900.0 -0.04 9327400.0 -105625.0 -0.0888179132848308 0.0132 0.0754 3068639 PK04_095039 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B20 compound treatment 9332560.0 -245000.0 -0.21 9462440.0 291000.0 0.24 9478480.0 45455.0 0.0382221845998768 0.0396 0.1227 3068006 PK04_095040 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B21 compound treatment 8988680.0 -589000.0 -0.51 8938000.0 -233000.0 -0.19 8990200.0 -442825.0 -0.372362532074369 -0.6195 -0.9412 3068601 PK04_095041 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCc4ccccc4)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B22 compound treatment 9068040.0 -510000.0 -0.44 8734000.0 -437000.0 -0.36 9559520.0 126495.0 0.106367071630435 -0.4013 -0.693 3068203 PK04_095042 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5Cl)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B23 compound treatment 9279600.0 -298000.0 -0.26 8985760.0 -186000.0 -0.15 8956440.0 -476585.0 -0.400750629139419 -0.4684 -0.9365 3187355 PK04_095043 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCC(F)(F)F)c4ccccc4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 B24 compound treatment 7975360.0 -1600000.0 -1.38 8003480.0 -1170000.0 -0.97 8671920.0 -761105.0 -0.639997707840484 -1.7251 -0.9569 3068156 PK04_095044 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C01 compound treatment 8393080.0 -1180000.0 -1.02 8228040.0 -943000.0 -0.78 8939400.0 -493625.0 -0.415079218416328 -1.2801 -0.9478 3187590 PK04_095045 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C02 compound treatment 9026440.0 -551000.0 -0.47 9079200.0 -92100.0 -0.08 9220080.0 -212945.0 -0.179061117580481 -0.4215 -0.8217 3187180 PK04_095046 CC(C)NC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C03 compound treatment 8208840.0 -1370000.0 -1.18 7716640.0 -1450000.0 -1.21 9305800.0 -127225.0 -0.106980913776687 -1.4387 -0.8513 3186493 PK04_095047 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C04 compound treatment 4706840.0 -4870000.0 -4.19 741400.0 -8430000.0 -6.99 5708960.0 -3724065.0 -3.13149048271786 -8.2658 -0.9464 3186427 PK04_095048 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C05 compound treatment 9035480.0 -542000.0 -0.47 8737720.0 -434000.0 -0.36 9459240.0 26215.0 0.0220436600876861 -0.4644 -0.7876 3187172 PK04_095049 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C06 compound treatment 9605720.0 27900.0 0.02 9154560.0 -16800.0 -0.01 9379080.0 -53945.0 -0.0453612528487593 -0.0204 -0.3827 3187080 PK04_095050 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C07 compound treatment 9686960.0 109000.0 0.09 9291160.0 120000.0 0.1 9570720.0 137695.0 0.115784923737323 0.1785 0.996 3186988 PK04_095051 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C08 compound treatment 3973320.0 -5600000.0 -4.82 3714160.0 -5460000.0 -4.53 3737120.0 -5695905.0 -4.78957061650778 -8.1638 -0.9996 3068011 PK04_095052 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C09 compound treatment 9309600.0 -268000.0 -0.23 8980440.0 -191000.0 -0.16 8924320.0 -508705.0 -0.427759683574531 -0.4717 -0.9226 3068498 PK04_095053 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C10 compound treatment 8739400.0 -838000.0 -0.72 8354720.0 -817000.0 -0.68 8267600.0 -1165425.0 -0.979982168899162 -1.3735 -0.9861 3186550 PK04_095054 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C11 mock treatment 9431360.0 -146000.0 -0.13 9588880.0 418000.0 0.35 9624240.0 191215.0 0.160788802733812 0.2201 0.5472 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C12 mock treatment 1.03326E7 755000.0 0.65 9570240.0 399000.0 0.33 9886600.0 453575.0 0.381401988337677 0.7863 0.9557 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C13 compound treatment 9788440.0 211000.0 0.18 9363000.0 192000.0 0.16 9917160.0 484135.0 0.407099270515044 0.4315 0.912 3187361 PK04_095055 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C14 compound treatment 9642320.0 64500.0 0.06 9544440.0 373000.0 0.31 9867880.0 434855.0 0.365660721244735 0.4219 0.8747 3068504 PK04_095056 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C15 mock treatment 9970880.0 393000.0 0.34 9499080.0 328000.0 0.27 9886520.0 453495.0 0.381334717965485 0.5725 0.9909 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C16 mock treatment 9700880.0 123000.0 0.11 9144720.0 -26600.0 -0.02 9586520.0 153495.0 0.129070822245255 0.1229 0.7299 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C17 compound treatment 9441440.0 -136000.0 -0.12 9564400.0 393000.0 0.33 1.030768E7 874655.0 0.735479592370591 0.5451 0.6705 3067969 PK04_095057 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCCN(C)C)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C18 compound treatment 9711760.0 134000.0 0.12 8755920.0 -415000.0 -0.34 9447880.0 14855.0 0.0124912672364134 -0.1252 -0.3443 3187359 PK04_095058 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C19 compound treatment 9381000.0 -197000.0 -0.17 8807040.0 -364000.0 -0.3 9470880.0 37855.0 0.031831499241631 -0.2539 -0.7298 3187087 PK04_095059 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C20 compound treatment 9527360.0 -50500.0 -0.04 9358400.0 187000.0 0.16 9532800.0 99775.0 0.0838987673182863 0.113 0.6218 3187443 PK04_095060 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C21 compound treatment 8566520.0 -1010000.0 -0.87 8581640.0 -590000.0 -0.49 8997800.0 -435225.0 -0.365971846716123 -0.9962 -0.9369 3067571 PK04_095061 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C22 compound treatment 8875240.0 -703000.0 -0.6 8975840.0 -195000.0 -0.16 9628000.0 194975.0 0.163950510226839 -0.3481 -0.5379 3187181 PK04_095062 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C23 compound treatment 8406080.0 -1170000.0 -1.01 8667120.0 -504000.0 -0.42 8765480.0 -667545.0 -0.561325007561869 -1.1478 -0.935 3187509 PK04_095063 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)c4ccc(cc4)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 C24 compound treatment 8650600.0 -927000.0 -0.8 8651440.0 -520000.0 -0.43 8431040.0 -1001985.0 -0.842548798510781 -1.1962 -0.9662 3068474 PK04_095064 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D01 compound treatment 7707160.0 -1870000.0 -1.61 7259760.0 -1910000.0 -1.59 7822000.0 -1611025.0 -1.35467814200894 -2.6272 -0.9971 3068587 PK04_095065 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(CC3(CC4CC5CC(C4)C3)C5)C(=O)c6ccccc26)c7ccc(CO)cc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D02 compound treatment 3782400.0 -5800000.0 -4.99 3859080.0 -5310000.0 -4.41 3698280.0 -5734745.0 -4.82223038220703 -8.2081 -0.9987 3068318 PK04_095066 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D03 compound treatment 9132520.0 -445000.0 -0.38 9155160.0 -16200.0 -0.01 9750880.0 317855.0 0.267277801913845 -0.0747 -0.1598 3187363 PK04_095067 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D04 compound treatment 9304240.0 -274000.0 -0.24 9550560.0 379000.0 0.31 9525400.0 92375.0 0.0776762578905207 0.0905 0.226 3186486 PK04_095068 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CCN7CCOCC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D05 compound treatment 9623040.0 45200.0 0.04 9682880.0 512000.0 0.42 9623320.0 190295.0 0.160015193453604 0.3599 0.7906 3187179 PK04_095069 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(=O)c3ccccc23)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D06 compound treatment 8800760.0 -777000.0 -0.67 7910520.0 -1260000.0 -1.05 8439160.0 -993865.0 -0.835720855733286 -1.4725 -0.9839 3187522 PK04_095070 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D07 compound treatment 9862240.0 284000.0 0.24 9499960.0 329000.0 0.27 9877720.0 444695.0 0.373934977024358 0.5146 0.983 3068515 PK04_095071 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D08 compound treatment 9915560.0 338000.0 0.29 9919200.0 748000.0 0.62 9677040.0 244015.0 0.205187248380573 0.6445 0.9011 3186872 PK04_095072 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D09 compound treatment 1.024836E7 671000.0 0.58 9001200.0 -170000.0 -0.14 9934200.0 501175.0 0.421427859791953 0.495 0.6796 3068609 PK04_095073 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D10 compound treatment 3903960.0 -5670000.0 -4.88 3688680.0 -5480000.0 -4.55 3522520.0 -5910505.0 -4.97002338991298 -8.3147 -0.9993 3186795 PK04_095074 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D11 mock treatment 1.010108E7 523000.0 0.45 9836680.0 665000.0 0.55 9867120.0 434095.0 0.36502165270891 0.7894 0.9862 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D12 mock treatment 1.040824E7 830000.0 0.71 9841760.0 670000.0 0.56 1.011504E7 682015.0 0.573492536132108 1.0648 0.9934 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D13 compound treatment 9681240.0 103000.0 0.09 9364360.0 193000.0 0.16 9792160.0 359135.0 0.301989313964949 0.3182 0.9009 3067964 PK04_095075 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D14 compound treatment 1.05814E7 1000000.0 0.86 9579000.0 408000.0 0.34 9861360.0 428335.0 0.360178185911082 0.9019 0.9064 3068230 PK04_095076 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D15 mock treatment 9806440.0 229000.0 0.2 9322120.0 151000.0 0.13 9172120.0 -260905.0 -0.219389705709622 0.0592 0.1848 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D16 mock treatment 9633920.0 56100.0 0.05 9301480.0 130000.0 0.11 9809000.0 375975.0 0.316149727311378 0.2727 0.808 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D17 compound treatment 9627320.0 49500.0 0.04 9560720.0 389000.0 0.32 9596400.0 163375.0 0.137378713210975 0.2904 0.8213 3068595 PK04_095077 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCc3ccccc3)c4ccccc4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D18 compound treatment 9906920.0 329000.0 0.28 9160880.0 -10400.0 -0.01 1.002576E7 592735.0 0.498418800765768 0.4463 0.7784 3186982 PK04_095078 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D19 compound treatment 8722880.0 -855000.0 -0.74 8673280.0 -498000.0 -0.41 8980480.0 -452545.0 -0.380535882295704 -0.883 -0.9539 3187440 PK04_095079 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D20 compound treatment 9211080.0 -367000.0 -0.32 9176360.0 5040.0 0.0 9408120.0 -24905.0 -0.0209421077430411 -0.1919 -0.6066 3068415 PK04_095080 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D21 compound treatment 9464840.0 -113000.0 -0.1 8789360.0 -382000.0 -0.32 9657040.0 224015.0 0.188369655332557 -0.1303 -0.3418 3068596 PK04_095081 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCC(F)(F)F)c3ccccc3C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D22 compound treatment 4041360.0 -5540000.0 -4.76 3241240.0 -5930000.0 -4.92 4224320.0 -5208705.0 -4.37989404985813 -8.12 -0.9988 3186713 PK04_095082 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D23 compound treatment 9443440.0 -134000.0 -0.12 8889440.0 -282000.0 -0.23 9429280.0 -3745.0 -0.00314909429824087 -0.2036 -0.7804 3187357 PK04_095083 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 D24 compound treatment 3172880.0 -6400000.0 -5.51 3451240.0 -5720000.0 -4.75 3705800.0 -5727225.0 -4.81590696722097 -8.7027 -0.9976 3068270 PK04_095084 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCCN6CCOCC6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E01 mock treatment 8513520.0 -1060000.0 -0.92 8933520.0 -238000.0 -0.2 9294200.0 -138825.0 -0.116735117744536 -0.7101 -0.7521 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E02 mock treatment 9385360.0 -192000.0 -0.17 8843200.0 -328000.0 -0.27 9718520.0 285495.0 0.240066936362156 -0.1142 -0.2862 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E03 compound treatment 8794080.0 -784000.0 -0.67 8591200.0 -580000.0 -0.48 8499240.0 -933785.0 -0.785200806217048 -1.1206 -0.9817 3068636 PK04_095085 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E04 compound treatment 9167960.0 -410000.0 -0.35 9073720.0 -97600.0 -0.08 9201760.0 -231265.0 -0.194466032812463 -0.3627 -0.8827 3186556 PK04_095086 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E05 compound treatment 9908600.0 331000.0 0.28 9210200.0 38900.0 0.03 8799720.0 -633305.0 -0.532533288263667 -0.1245 -0.2058 3187587 PK04_095087 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E06 compound treatment 7569280.0 -2010000.0 -1.73 6063120.0 -3110000.0 -2.58 7975680.0 -1457345.0 -1.22545175702799 -3.1942 -0.9571 3186428 PK04_095088 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E07 compound treatment 9957280.0 379000.0 0.33 9009480.0 -162000.0 -0.13 9608880.0 175855.0 0.147872891272937 0.1964 0.5131 3187266 PK04_095089 CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E08 compound treatment 1.045884E7 881000.0 0.76 9372520.0 201000.0 0.17 9681440.0 248415.0 0.208887118851136 0.6547 0.8143 3187351 PK04_095090 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E09 mock treatment 9841960.0 264000.0 0.23 9542160.0 371000.0 0.31 9931560.0 498535.0 0.419207937509615 0.5509 0.9707 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E10 mock treatment 9806960.0 229000.0 0.2 9648240.0 477000.0 0.4 1.000912E7 576095.0 0.484426563349819 0.622 0.9484 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E11 compound treatment 9840920.0 263000.0 0.23 8967760.0 -204000.0 -0.17 1.034892E7 915895.0 0.770157469235599 0.4779 0.5826 3068004 PK04_095091 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E12 compound treatment 8711640.0 -866000.0 -0.75 8627160.0 -544000.0 -0.45 8805480.0 -627545.0 -0.527689821465838 -0.9957 -0.9773 3186500 PK04_095092 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E13 compound treatment 9799120.0 221000.0 0.19 9661120.0 490000.0 0.41 9913680.0 480655.0 0.40417300932469 0.5779 0.9569 3187346 PK04_095093 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCN3CCOCC3)c4ccccc4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E14 compound treatment 1.042284E7 845000.0 0.73 9797520.0 626000.0 0.52 1.021264E7 779615.0 0.655562390206422 1.0983 0.9909 3187262 PK04_095094 CC(C)N1[C@H]([C@H](C(=O)NCCN2CCOCC2)c3ccccc3C1=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E15 compound treatment 4634480.0 -4940000.0 -4.25 4111960.0 -5060000.0 -4.2 4508920.0 -4924105.0 -4.14057970078487 -7.2701 -0.9999 3067574 PK04_095095 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E16 compound treatment 9665280.0 87500.0 0.08 9359800.0 188000.0 0.16 9666960.0 233935.0 0.196711181484373 0.2473 0.9428 3187350 PK04_095096 COCCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E17 mock treatment 9357280.0 -221000.0 -0.19 9770720.0 599000.0 0.5 1.01412E7 708175.0 0.595489947838912 0.5213 0.6527 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E18 mock treatment 9430360.0 -147000.0 -0.13 8928400.0 -243000.0 -0.2 9751480.0 318455.0 0.267782329705286 -0.035 -0.0977 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E19 compound treatment 9180880.0 -397000.0 -0.34 8624920.0 -546000.0 -0.45 9188400.0 -244625.0 -0.205700184968537 -0.5777 -0.9569 3068657 PK04_095097 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E20 compound treatment 8508920.0 -1070000.0 -0.92 8053320.0 -1120000.0 -0.93 8298520.0 -1134505.0 -0.95398217004693 -1.6174 -0.9999 3068140 PK04_095098 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E21 compound treatment 9349600.0 -228000.0 -0.2 8879240.0 -292000.0 -0.24 9134320.0 -298705.0 -0.251174956570371 -0.3983 -0.9946 3186562 PK04_095099 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E22 compound treatment 9025520.0 -552000.0 -0.48 8750680.0 -421000.0 -0.35 9092600.0 -340425.0 -0.28625645566853 -0.6412 -0.9782 3187591 PK04_095100 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E23 compound treatment 9505320.0 -72500.0 -0.06 8993680.0 -178000.0 -0.15 9724800.0 291775.0 0.245347660579233 0.0205 0.0701 3187263 PK04_095101 CC(C)N1[C@H]([C@H](C(=O)NCc2ccccc2)c3ccccc3C1=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 E24 compound treatment 9163640.0 -414000.0 -0.36 8128160.0 -1040000.0 -0.87 8920480.0 -512545.0 -0.43098866143975 -0.9543 -0.9261 3068517 PK04_095102 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F01 mock treatment 8317360.0 -1260000.0 -1.08 7893320.0 -1280000.0 -1.06 9117440.0 -315585.0 -0.265369005102895 -1.3916 -0.9037 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F02 mock treatment 9257680.0 -320000.0 -0.28 9481640.0 310000.0 0.26 9682560.0 249535.0 0.209828904061825 0.1107 0.2565 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F03 compound treatment 9362520.0 -215000.0 -0.19 8798880.0 -372000.0 -0.31 9197640.0 -235385.0 -0.197930456980354 -0.3996 -0.9722 3187079 PK04_095103 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F04 compound treatment 9325880.0 -252000.0 -0.22 9673000.0 502000.0 0.42 9278120.0 -154905.0 -0.130256462555141 0.0399 0.0819 3068331 PK04_095104 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F05 compound treatment 8957200.0 -621000.0 -0.53 8790600.0 -381000.0 -0.32 8883840.0 -549185.0 -0.461798491903714 -0.7573 -0.9791 3068563 PK04_095105 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F06 compound treatment 9959840.0 382000.0 0.33 9279000.0 108000.0 0.09 9878320.0 445295.0 0.374439504815799 0.4576 0.9039 3186879 PK04_095106 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCCN6CCOCC6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F07 compound treatment 3817320.0 -5760000.0 -4.96 3616160.0 -5560000.0 -4.61 3562280.0 -5870745.0 -4.93659001493353 -8.3731 -0.9995 3187523 PK04_095107 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F08 compound treatment 9317440.0 -260000.0 -0.22 9417880.0 247000.0 0.2 9705480.0 272455.0 0.22910186569485 0.121 0.3182 3186563 PK04_095108 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F09 mock treatment 1.005384E7 476000.0 0.41 9019520.0 -152000.0 -0.13 9599200.0 166175.0 0.139733176237697 0.2445 0.5424 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F10 mock treatment 9629480.0 51700.0 0.04 9087520.0 -83800.0 -0.07 9669120.0 236095.0 0.198527481533559 0.1002 0.4659 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F11 compound treatment 1.034948E7 772000.0 0.66 9515640.0 344000.0 0.29 9753960.0 320935.0 0.26986771124324 0.7042 0.9125 3187257 PK04_095109 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F12 compound treatment 4562520.0 -5020000.0 -4.32 3720440.0 -5450000.0 -4.52 3622680.0 -5810345.0 -4.88580088392852 -7.9236 -0.9987 3068241 PK04_095110 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F13 compound treatment 1.005936E7 482000.0 0.41 9778640.0 607000.0 0.5 9992000.0 558975.0 0.470030703700718 0.8015 0.9968 3068554 PK04_095111 COCCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F14 compound treatment 9882960.0 305000.0 0.26 1.001672E7 845000.0 0.7 9804880.0 371855.0 0.312685303143487 0.7371 0.9082 3068362 PK04_095112 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)Sc4ccc(C)cc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F15 compound treatment 8642960.0 -935000.0 -0.8 7974320.0 -1200000.0 -0.99 8629160.0 -803865.0 -0.675953721777141 -1.4281 -0.9878 3186423 PK04_095113 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F16 compound treatment 9755000.0 177000.0 0.15 8677400.0 -494000.0 -0.41 9721160.0 288135.0 0.242286858644494 -0.0086 -0.0173 3068012 PK04_095114 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F17 mock treatment 1.005464E7 477000.0 0.41 8879760.0 -292000.0 -0.24 1.007896E7 645935.0 0.543153598273488 0.4109 0.5687 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F18 mock treatment 1.005676E7 479000.0 0.41 8879160.0 -292000.0 -0.24 9717480.0 284455.0 0.23919242152366 0.2361 0.4417 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F19 compound treatment 7085640.0 -2490000.0 -2.14 7118760.0 -2050000.0 -1.7 7169840.0 -2263185.0 -1.90306621611863 -3.3202 -0.9956 3067568 PK04_095115 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F20 compound treatment 3883400.0 -5690000.0 -4.9 3527920.0 -5640000.0 -4.68 3361800.0 -6071225.0 -5.10516956764684 -8.4799 -0.9994 3068266 PK04_095116 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F21 compound treatment 8517080.0 -1060000.0 -0.91 6972840.0 -2200000.0 -1.82 7911680.0 -1521345.0 -1.27926805478164 -2.3186 -0.9631 3186419 PK04_095117 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F22 compound treatment 3863480.0 -5710000.0 -4.92 2664600.0 -6510000.0 -5.4 3749320.0 -5683705.0 -4.77931188474849 -8.7151 -0.9986 3187524 PK04_095118 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F23 compound treatment 9568200.0 -9620.0 -0.01 8822000.0 -349000.0 -0.29 9559960.0 126935.0 0.106737058677491 -0.1105 -0.3576 3068017 PK04_095119 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)O)c4ccccc4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 F24 compound treatment 8532360.0 -1050000.0 -0.9 8308040.0 -863000.0 -0.72 8360600.0 -1072425.0 -0.901780361225891 -1.4536 -0.9947 3186554 PK04_095120 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G01 compound treatment 7395680.0 -2180000.0 -1.88 7685760.0 -1490000.0 -1.23 8192800.0 -1240225.0 -1.04287996689874 -2.3979 -0.9682 3186418 PK04_095121 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G02 compound treatment 9014440.0 -563000.0 -0.48 8879960.0 -291000.0 -0.24 9248440.0 -184585.0 -0.155213770638395 -0.5091 -0.9033 3067966 PK04_095122 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCN3CCOCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G03 mock treatment 9592840.0 15000.0 0.01 9802840.0 632000.0 0.52 9360520.0 -72505.0 -0.0609679791973175 0.2747 0.5207 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G04 mock treatment 1.011956E7 542000.0 0.47 9574000.0 403000.0 0.33 9896760.0 463735.0 0.389945325606069 0.6872 0.9908 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G05 compound treatment 9239520.0 -338000.0 -0.29 8941160.0 -230000.0 -0.19 9560560.0 127535.0 0.107241586468932 -0.2164 -0.594 3068153 PK04_095123 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G06 compound treatment 9615440.0 37600.0 0.03 9198120.0 26800.0 0.02 9390360.0 -42665.0 -0.0358761303696786 0.0108 0.2034 3187356 PK04_095124 COCCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G07 compound treatment 9943080.0 365000.0 0.31 9152160.0 -19200.0 -0.02 9360720.0 -72305.0 -0.0607998032668373 0.1372 0.428 3187173 PK04_095125 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G08 compound treatment 1.046568E7 888000.0 0.76 8868120.0 -303000.0 -0.25 9789320.0 356295.0 0.299601215752131 0.4689 0.5463 3068514 PK04_095126 CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G09 compound treatment 9282280.0 -296000.0 -0.25 8260680.0 -911000.0 -0.76 8814120.0 -618905.0 -0.520424621269096 -0.8835 -0.9281 3187442 PK04_095127 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G10 compound treatment 1.015676E7 579000.0 0.5 9389160.0 218000.0 0.18 9156920.0 -276105.0 -0.232171076426113 0.258 0.4458 3068420 PK04_095128 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G11 compound treatment 9919520.0 342000.0 0.29 9622200.0 451000.0 0.37 8947800.0 -485225.0 -0.408015829336161 0.1502 0.2396 3187434 PK04_095129 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G12 compound treatment 9260640.0 -317000.0 -0.27 8678560.0 -493000.0 -0.41 7824000.0 -1609025.0 -1.35299638270414 -1.1748 -0.8161 3186416 PK04_095130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G13 compound treatment 1.036664E7 789000.0 0.68 9979000.0 808000.0 0.67 1.012964E7 696615.0 0.585769379057159 1.117 0.9979 3068507 PK04_095131 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G14 compound treatment 1.027452E7 697000.0 0.6 9891440.0 720000.0 0.6 9645520.0 212495.0 0.178682721736901 0.7943 0.9181 3187162 PK04_095132 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G15 compound treatment 9746240.0 168000.0 0.14 9057440.0 -114000.0 -0.09 9821960.0 388935.0 0.327047527606492 0.218 0.5891 3068602 PK04_095133 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G16 compound treatment 9730200.0 152000.0 0.13 8814880.0 -356000.0 -0.3 9559360.0 126335.0 0.106232530886051 -0.0337 -0.0989 3187426 PK04_095134 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G17 compound treatment 9369400.0 -208000.0 -0.18 9221680.0 50400.0 0.04 9506560.0 73535.0 0.0618340852392903 -0.0437 -0.2251 3067567 PK04_095135 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G18 compound treatment 4539200.0 -5040000.0 -4.34 4039360.0 -5130000.0 -4.26 3627120.0 -5805905.0 -4.88206737827186 -7.7803 -0.9981 3187525 PK04_095136 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G19 mock treatment 1.01126E7 535000.0 0.46 8699520.0 -472000.0 -0.39 9624200.0 191175.0 0.160755167547716 0.1326 0.212 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G20 mock treatment 9795080.0 217000.0 0.19 9149840.0 -21500.0 -0.02 9482080.0 49055.0 0.0412493513485195 0.1215 0.6317 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G21 compound treatment 9727360.0 150000.0 0.13 9450960.0 280000.0 0.23 9363200.0 -69825.0 -0.0587144217288834 0.1743 0.6416 3187167 PK04_095137 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G22 compound treatment 9540800.0 -37000.0 -0.03 9254400.0 83100.0 0.07 9632960.0 199935.0 0.168121273302747 0.1185 0.6422 3187174 PK04_095138 COc1ccccc1CN2[C@H]([C@H](C(=O)NC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G23 compound treatment 9210280.0 -368000.0 -0.32 9101320.0 -70000.0 -0.06 9243080.0 -189945.0 -0.159720885575263 -0.3084 -0.8588 3068478 PK04_095139 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 G24 compound treatment 9223520.0 -354000.0 -0.3 8652640.0 -519000.0 -0.43 8798720.0 -634305.0 -0.533374167916067 -0.7324 -0.9765 3068471 PK04_095140 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H01 compound treatment 8345040.0 -1230000.0 -1.06 7996000.0 -1180000.0 -0.98 7885720.0 -1547305.0 -1.30109729055797 -1.9267 -0.9924 3068149 PK04_095141 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H02 compound treatment 7790760.0 -1790000.0 -1.54 5404720.0 -3770000.0 -3.12 8650600.0 -782425.0 -0.657925262029669 -3.0718 -0.8667 3068236 PK04_095142 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H03 mock treatment 9382440.0 -195000.0 -0.17 8748840.0 -422000.0 -0.35 9508160.0 75135.0 0.0631794926831315 -0.263 -0.6677 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H04 mock treatment 9997720.0 420000.0 0.36 9345160.0 174000.0 0.14 9510680.0 77655.0 0.0652985094071814 0.3296 0.8354 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H05 compound treatment 1.01712E7 593000.0 0.51 9305400.0 134000.0 0.11 9823000.0 389975.0 0.327922042444988 0.5484 0.8888 3187083 PK04_095143 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H06 compound treatment 5580120.0 -4000000.0 -3.44 3493320.0 -5680000.0 -4.71 4499160.0 -4933865.0 -4.1487866861923 -7.1012 -0.9921 3068265 PK04_095144 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H07 compound treatment 9270640.0 -307000.0 -0.26 9003240.0 -168000.0 -0.14 9252560.0 -180465.0 -0.151749346470504 -0.3207 -0.9569 3068458 PK04_095145 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H08 compound treatment 1.000148E7 424000.0 0.36 1.019448E7 1020000.0 0.85 9396960.0 -36065.0 -0.0303263246638336 0.6831 0.739 3068401 PK04_095146 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H09 compound treatment 9599120.0 21300.0 0.02 9647200.0 476000.0 0.39 9190800.0 -242225.0 -0.203682073802775 0.1209 0.272 3187071 PK04_095147 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H10 compound treatment 9438440.0 -139000.0 -0.12 8599080.0 -572000.0 -0.47 9040200.0 -392825.0 -0.330318549454331 -0.534 -0.9042 3068139 PK04_095148 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H11 compound treatment 1.024008E7 662000.0 0.57 9509520.0 338000.0 0.28 1.02606E7 827575.0 0.695890978335563 0.8928 0.9475 3187589 PK04_095149 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H12 compound treatment 1.03586E7 781000.0 0.67 9845480.0 674000.0 0.56 1.063916E7 1206135.0 1.0142143795484 1.2964 0.9682 3186627 PK04_095150 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H13 compound treatment 1.07596E7 1180000.0 1.02 9296240.0 125000.0 0.1 9723720.0 290695.0 0.24443951055464 0.7882 0.7498 3187261 PK04_095151 CC(C)N1[C@H]([C@H](C(=O)NC2CC2)c3ccccc3C1=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H14 compound treatment 1.038484E7 807000.0 0.69 1.050912E7 1340000.0 1.11 9683960.0 250935.0 0.211006135575186 1.1636 0.8774 3186980 PK04_095152 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H15 compound treatment 9669840.0 92000.0 0.08 9546120.0 375000.0 0.31 1.045312E7 1020095.0 0.857777129015759 0.7205 0.7867 3187166 PK04_095153 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H16 compound treatment 1.006704E7 489000.0 0.42 9959400.0 788000.0 0.65 9920640.0 487615.0 0.410025531705399 0.8573 0.9752 3186978 PK04_095154 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H17 compound treatment 1.014856E7 571000.0 0.49 9634960.0 464000.0 0.38 9817440.0 384415.0 0.32324675157764 0.6923 0.9853 3187349 PK04_095155 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCCN(C)C)c3ccccc3C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H18 compound treatment 9799200.0 221000.0 0.19 9388880.0 218000.0 0.18 1.01478E7 714775.0 0.601039753544757 0.5612 0.8557 3068412 PK04_095156 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H19 mock treatment 9871600.0 294000.0 0.25 9741280.0 570000.0 0.47 9911240.0 478215.0 0.402121262972832 0.6511 0.9715 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H20 mock treatment 9901800.0 324000.0 0.28 9632760.0 461000.0 0.38 9373760.0 -59265.0 -0.0498347325995313 0.3532 0.7417 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H21 compound treatment 9552920.0 -24900.0 -0.02 9098520.0 -72800.0 -0.06 9501160.0 68135.0 0.0572933351163261 -0.0142 -0.1647 3187512 PK04_095157 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H22 compound treatment 3928320.0 -5650000.0 -4.86 3615360.0 -5560000.0 -4.61 4104080.0 -5328945.0 -4.4810014192628 -8.0553 -0.9994 3186806 PK04_095158 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H23 compound treatment 8999960.0 -578000.0 -0.5 9357880.0 187000.0 0.15 9102160.0 -330865.0 -0.278217646191579 -0.3584 -0.607 3068599 PK04_095159 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NC4CC4)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 H24 compound treatment 9188520.0 -389000.0 -0.34 8400120.0 -771000.0 -0.64 8543000.0 -890025.0 -0.748403912627991 -0.9949 -0.9566 3187586 PK04_095160 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I01 compound treatment 8170840.0 -1410000.0 -1.21 8007960.0 -1160000.0 -0.97 8772520.0 -660505.0 -0.555405214808967 -1.577 -0.9586 3187165 PK04_095161 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I02 compound treatment 9012800.0 -565000.0 -0.49 8233160.0 -938000.0 -0.78 8569040.0 -863985.0 -0.726507406479475 -1.1495 -0.9821 3068418 PK04_095162 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I03 compound treatment 9727360.0 150000.0 0.13 8619560.0 -552000.0 -0.46 9625040.0 192015.0 0.161461506455733 -0.0967 -0.1927 3187178 PK04_095163 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I04 compound treatment 9586440.0 8620.0 0.01 8914640.0 -257000.0 -0.21 8956360.0 -476665.0 -0.400817899511611 -0.3501 -0.7712 3068019 PK04_095164 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I05 mock treatment 9215200.0 -363000.0 -0.31 9022840.0 -148000.0 -0.12 9091040.0 -341985.0 -0.287568227926276 -0.4173 -0.9444 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I06 mock treatment 9578280.0 459.0 0.0 9268720.0 97400.0 0.08 9703720.0 270695.0 0.227621917506625 0.1783 0.7382 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I07 compound treatment 9493720.0 -84100.0 -0.07 8862160.0 -309000.0 -0.26 9285920.0 -147105.0 -0.123697601266415 -0.2613 -0.8893 3068542 PK04_095165 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3Cc4ccccc4C3)C(=O)c5ccccc25)c6ccc(CO)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I08 compound treatment 9856960.0 279000.0 0.24 9266560.0 95200.0 0.08 1.008772E7 654695.0 0.550519704028519 0.5022 0.8289 3187345 PK04_095166 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I09 compound treatment 4131800.0 -5450000.0 -4.69 3537400.0 -5630000.0 -4.67 3702680.0 -5730345.0 -4.81853051173646 -8.1864 -0.9999 3067971 PK04_095167 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I10 compound treatment 9916960.0 339000.0 0.29 9265720.0 94400.0 0.08 9149120.0 -283905.0 -0.238729937714839 0.0759 0.1971 3068641 PK04_095168 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I11 compound treatment 9816480.0 239000.0 0.21 9385000.0 214000.0 0.18 9791000.0 357975.0 0.301013893568164 0.3947 0.974 3187358 PK04_095169 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I12 compound treatment 1.041484E7 837000.0 0.72 9683840.0 513000.0 0.43 9999200.0 566175.0 0.476085037198003 0.9362 0.9727 3068653 PK04_095170 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I13 compound treatment 9833680.0 256000.0 0.22 9537600.0 366000.0 0.3 9796160.0 363135.0 0.305352832574552 0.4789 0.9898 3067962 PK04_095171 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I14 compound treatment 9290560.0 -287000.0 -0.25 8577120.0 -594000.0 -0.49 9357800.0 -75225.0 -0.0632551718518476 -0.4638 -0.8357 3068606 PK04_095172 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I15 compound treatment 1.0508E7 930000.0 0.8 8848880.0 -322000.0 -0.27 9527560.0 94535.0 0.0794925579397063 0.3537 0.4172 3068476 PK04_095173 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I16 compound treatment 9265840.0 -312000.0 -0.27 8111920.0 -1060000.0 -0.88 8648760.0 -784265.0 -0.659472480590086 -1.0432 -0.9223 3186417 PK04_095174 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I17 compound treatment 9545720.0 -32100.0 -0.03 9153200.0 -18100.0 -0.02 9163200.0 -269825.0 -0.226890352209036 -0.1556 -0.6794 3187268 PK04_095175 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I18 compound treatment 9610880.0 33100.0 0.03 9588480.0 417000.0 0.35 9450440.0 17415.0 0.0146439191465593 0.2247 0.6465 3187264 PK04_095176 CC(C)N1[C@H]([C@H](C(=O)NCC(F)(F)F)c2ccccc2C1=O)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I19 compound treatment 8890000.0 -688000.0 -0.59 7800880.0 -1370000.0 -1.14 7989760.0 -1443265.0 -1.21361217152219 -1.6988 -0.9624 3186499 PK04_095177 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I20 compound treatment 9502840.0 -75000.0 -0.06 9130920.0 -40400.0 -0.03 9534000.0 100975.0 0.0849078229011673 -0.0076 -0.0678 3068422 PK04_095178 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I21 mock treatment 9605240.0 27400.0 0.02 8925440.0 -246000.0 -0.2 9188920.0 -244105.0 -0.205262927549289 -0.2226 -0.7669 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I22 mock treatment 8850800.0 -727000.0 -0.63 8933480.0 -238000.0 -0.2 8932840.0 -500185.0 -0.420595388936077 -0.718 -0.9213 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I23 compound treatment 9024400.0 -553000.0 -0.48 8448520.0 -723000.0 -0.6 9029440.0 -403585.0 -0.339366414514163 -0.8171 -0.9755 3068550 PK04_095179 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(C)C)C(=O)c3ccccc23)c4ccc(CO)cc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 I24 compound treatment 8534160.0 -1040000.0 -0.9 8428080.0 -743000.0 -0.62 1.212628E7 2693255.0 2.26470332822662 0.433 0.1723 3187258 PK04_095180 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4Cc5ccccc5C4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J01 compound treatment 8881400.0 -696000.0 -0.6 8197840.0 -973000.0 -0.81 8805080.0 -627945.0 -0.528026173326798 -1.1171 -0.9835 3187273 PK04_095181 CC(C)CNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J02 compound treatment 8395480.0 -1180000.0 -1.02 8583240.0 -588000.0 -0.49 8960600.0 -472425.0 -0.397252569785432 -1.0985 -0.9182 3186630 PK04_095182 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J03 compound treatment 9722120.0 144000.0 0.12 8647440.0 -524000.0 -0.43 8958040.0 -474985.0 -0.399405221695577 -0.4098 -0.6794 3187353 PK04_095183 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(=O)c3ccccc32)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J04 compound treatment 1.006464E7 487000.0 0.42 8722080.0 -449000.0 -0.37 9407480.0 -25545.0 -0.0214802707205775 0.0143 0.0255 3187588 PK04_095184 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)O)c3ccccc3C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J05 mock treatment 1.02582E7 680000.0 0.59 9407600.0 236000.0 0.2 9324880.0 -108145.0 -0.0909369300088807 0.3987 0.6388 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J06 mock treatment 1.014604E7 568000.0 0.49 9898040.0 727000.0 0.6 8839880.0 -593145.0 -0.498763561423252 0.3424 0.3711 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J07 compound treatment 9186720.0 -391000.0 -0.34 7445200.0 -1730000.0 -1.43 6932160.0 -2500865.0 -2.10292649190124 -2.2352 -0.871 3186420 PK04_095185 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J08 compound treatment 3794840.0 -5780000.0 -4.98 3700000.0 -5470000.0 -4.54 3735240.0 -5697785.0 -4.79115147025429 -8.2602 -0.9993 3186722 PK04_095186 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J09 compound treatment 5890640.0 -3690000.0 -3.17 3794200.0 -5380000.0 -4.46 4481080.0 -4951945.0 -4.16398979030771 -6.8116 -0.9903 3186426 PK04_095187 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J10 compound treatment 1.030528E7 727000.0 0.63 1.005592E7 885000.0 0.73 9454480.0 21455.0 0.0180410729422584 0.7956 0.8246 3186639 PK04_095188 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J11 compound treatment 1.002908E7 451000.0 0.39 9309200.0 138000.0 0.11 9441560.0 8535.0 0.00717690783324053 0.2944 0.7271 3187270 PK04_095189 CC(C)NC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J12 compound treatment 1.07666E7 1190000.0 1.02 9267800.0 96500.0 0.08 9233200.0 -199825.0 -0.168028776540983 0.5399 0.5192 3067980 PK04_095190 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J13 compound treatment 1.02316E7 654000.0 0.56 5068040.0 -4100000.0 -3.4 7799240.0 -1633785.0 -1.37381656289758 -2.4336 -0.6553 3186421 PK04_095191 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J14 compound treatment 9570920.0 -6900.0 -0.01 8143640.0 -1030000.0 -0.85 8603760.0 -829265.0 -0.69731206494812 -0.8982 -0.8155 3068150 PK04_095192 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J15 compound treatment 1.00298E7 452000.0 0.39 9076400.0 -94900.0 -0.08 1.00108E7 577775.0 0.485839241165852 0.4596 0.7327 3068598 PK04_095193 CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J16 compound treatment 3865160.0 -5710000.0 -4.92 3096400.0 -6070000.0 -5.04 3056840.0 -6376185.0 -5.36160422644297 -8.8437 -0.9993 3068324 PK04_095194 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J17 compound treatment 4456440.0 -5120000.0 -4.41 3441920.0 -5730000.0 -4.75 3404680.0 -6028345.0 -5.06911264815189 -8.2155 -0.9984 3067973 PK04_095195 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J18 compound treatment 9312640.0 -265000.0 -0.23 8893440.0 -278000.0 -0.23 9104880.0 -328145.0 -0.275930453537049 -0.4242 -0.996 3068414 PK04_095196 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J19 compound treatment 9142920.0 -435000.0 -0.37 8594960.0 -576000.0 -0.48 8896480.0 -536545.0 -0.451169773097369 -0.7526 -0.9949 3187085 PK04_095197 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J20 compound treatment 1.003384E7 456000.0 0.39 1.001204E7 841000.0 0.7 9788440.0 355415.0 0.298861241658018 0.8018 0.9386 3186884 PK04_095198 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J21 mock treatment 9721800.0 144000.0 0.12 9300040.0 129000.0 0.11 9028680.0 -404345.0 -0.340005483049987 -0.0631 -0.1673 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J22 mock treatment 9367000.0 -211000.0 -0.18 9058200.0 -113000.0 -0.09 9322720.0 -110305.0 -0.0927532300580664 -0.2125 -0.9471 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J23 compound treatment 9853920.0 276000.0 0.24 9155200.0 -16100.0 -0.01 8645560.0 -787465.0 -0.662163295477769 -0.2528 -0.3593 3187082 PK04_095199 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 J24 compound treatment 8603280.0 -975000.0 -0.84 8919600.0 -252000.0 -0.21 9240280.0 -192745.0 -0.162075348601985 -0.6984 -0.7942 3068227 PK04_095200 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K01 compound treatment 4130440.0 -5450000.0 -4.69 4300480.0 -4870000.0 -4.04 4473040.0 -4959985.0 -4.17075046271301 -7.4476 -0.9979 3187514 PK04_095201 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K02 compound treatment 8812760.0 -765000.0 -0.66 7907160.0 -1260000.0 -1.05 8750080.0 -682945.0 -0.574274554208841 -1.3172 -0.965 3187168 PK04_095202 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccc(OC(F)(F)F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K03 compound treatment 4152280.0 -5430000.0 -4.67 4414160.0 -4760000.0 -3.95 7938520.0 -1494505.0 -1.25669884491121 -5.6999 -0.9132 3068143 PK04_095203 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC5CC5)c6ccccc6C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K04 compound treatment 9158160.0 -420000.0 -0.36 8453360.0 -718000.0 -0.6 9488960.0 55935.0 0.0470346033570368 -0.5252 -0.7523 3187275 PK04_095204 CN(C)CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K05 compound treatment 9887400.0 310000.0 0.27 9102320.0 -69000.0 -0.06 9401080.0 -31945.0 -0.0268619004959424 0.1053 0.3844 3187271 PK04_095205 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K06 compound treatment 9508800.0 -69000.0 -0.06 8747120.0 -424000.0 -0.35 9088920.0 -344105.0 -0.289350892789365 -0.4045 -0.8805 3186561 PK04_095206 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K07 mock treatment 9096760.0 -481000.0 -0.41 8800120.0 -371000.0 -0.31 9216120.0 -216905.0 -0.182391001003988 -0.5221 -0.9541 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K08 mock treatment 9848640.0 271000.0 0.23 9176880.0 5560.0 0.0 9298720.0 -134305.0 -0.112934341715685 0.072 0.2781 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K09 compound treatment 9019120.0 -559000.0 -0.48 9076240.0 -95100.0 -0.08 8749560.0 -683465.0 -0.574711811628089 -0.655 -0.8693 3068519 PK04_095207 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K10 compound treatment 9424920.0 -153000.0 -0.13 8934400.0 -237000.0 -0.2 9135200.0 -297825.0 -0.250434982476258 -0.334 -0.9697 3068466 PK04_095208 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K11 compound treatment 9055120.0 -523000.0 -0.45 7618600.0 -1550000.0 -1.29 8817040.0 -615985.0 -0.517969252684085 -1.3025 -0.8925 3068556 PK04_095209 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K12 compound treatment 2651920.0 -6930000.0 -5.96 1255880.0 -7920000.0 -6.57 1548800.0 -7884225.0 -6.62968437744942 -11.0602 -0.9989 3067978 PK04_095210 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K13 compound treatment 9580520.0 2700.0 0.0 9258240.0 86900.0 0.07 9743000.0 309975.0 0.260651670252927 0.1935 0.7153 3068499 PK04_095211 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K14 compound treatment 9800800.0 223000.0 0.19 8374440.0 -797000.0 -0.66 9026600.0 -406425.0 -0.341754512726981 -0.4682 -0.6092 3068588 PK04_095212 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K15 mock treatment 9783560.0 206000.0 0.18 9624520.0 453000.0 0.38 9413880.0 -19145.0 -0.0160986409452126 0.31 0.7454 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K16 mock treatment 9424040.0 -154000.0 -0.13 9203320.0 32000.0 0.03 9624080.0 191055.0 0.160654261989428 0.0317 0.1509 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K17 compound treatment 3822240.0 -5760000.0 -4.95 3301000.0 -5870000.0 -4.87 3655240.0 -5777785.0 -4.85842184244636 -8.4765 -1.0 3068009 PK04_095213 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K18 compound treatment 8095120.0 -1480000.0 -1.28 5875240.0 -3300000.0 -2.73 6026880.0 -3406145.0 -2.8641580236266 -3.969 -0.954 3186498 PK04_095214 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCCN(C)C)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K19 compound treatment 9290640.0 -287000.0 -0.25 9607040.0 436000.0 0.36 9449200.0 16175.0 0.0136012283775824 0.0738 0.1686 3068472 PK04_095215 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K20 compound treatment 8977920.0 -600000.0 -0.52 8924040.0 -247000.0 -0.21 9623520.0 190495.0 0.160183369384084 -0.324 -0.5604 3187259 PK04_095216 COCCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K21 compound treatment 9023520.0 -554000.0 -0.48 8756600.0 -415000.0 -0.34 8782400.0 -650625.0 -0.547097323843248 -0.7899 -0.9834 3187078 PK04_095217 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K22 compound treatment 9069760.0 -508000.0 -0.44 8821160.0 -350000.0 -0.29 9355920.0 -77105.0 -0.064836025598361 -0.4576 -0.8651 3068508 PK04_095218 COc1ccccc1CN2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K23 mock treatment 8798440.0 -779000.0 -0.67 9080520.0 -90800.0 -0.08 9073640.0 -359385.0 -0.302199533878049 -0.6052 -0.8184 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 K24 mock treatment 8749440.0 -828000.0 -0.71 9123760.0 -47600.0 -0.04 8475840.0 -957185.0 -0.804877390083226 -0.8991 -0.8356 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L01 compound treatment 7812960.0 -1760000.0 -1.52 8099480.0 -1070000.0 -0.89 8836920.0 -596105.0 -0.501252565194358 -1.6797 -0.9179 3187175 PK04_095219 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCCN(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L02 compound treatment 3016000.0 -6560000.0 -5.65 3036160.0 -6140000.0 -5.09 2836720.0 -6596305.0 -5.54669865552943 -9.4013 -0.999 3186714 PK04_095220 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L03 compound treatment 8593240.0 -985000.0 -0.85 8716000.0 -455000.0 -0.38 8906120.0 -526905.0 -0.443063693248225 -0.9631 -0.9368 3067967 PK04_095221 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCc3ccccc3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L04 compound treatment 9943960.0 366000.0 0.32 9307320.0 136000.0 0.11 9637800.0 204775.0 0.172191130820367 0.3465 0.9205 3186429 PK04_095222 CC(C)CN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L05 compound treatment 9679640.0 102000.0 0.09 9145400.0 -25900.0 -0.02 8908440.0 -524585.0 -0.441112852454655 -0.2165 -0.4808 3068540 PK04_095223 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L06 compound treatment 9609240.0 31400.0 0.03 9302800.0 131000.0 0.11 9329400.0 -103625.0 -0.0871361539800293 0.0283 0.1989 3186551 PK04_095224 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L07 mock treatment 9526480.0 -51300.0 -0.04 9071680.0 -99600.0 -0.08 9958720.0 525695.0 0.44204622886882 0.182 0.4027 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L08 mock treatment 9239040.0 -339000.0 -0.29 9558800.0 387000.0 0.32 9347880.0 -85145.0 -0.0715966980036632 -0.0241 -0.0548 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L09 compound treatment 9216400.0 -361000.0 -0.31 8637640.0 -534000.0 -0.44 8409960.0 -1023065.0 -0.860274541583389 -0.9319 -0.9169 3187518 PK04_095225 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L10 compound treatment 9507680.0 -70100.0 -0.06 9210560.0 39200.0 0.03 9849520.0 416495.0 0.350222170826657 0.1861 0.5216 3068144 PK04_095226 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCc5ccccc5)c6ccccc6C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L11 compound treatment 9864920.0 287000.0 0.25 9317280.0 146000.0 0.12 9706640.0 273615.0 0.230077286091635 0.3454 0.963 3187076 PK04_095227 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L12 compound treatment 3837520.0 -5740000.0 -4.94 3356920.0 -5810000.0 -4.82 3487080.0 -5945945.0 -4.99982416479407 -8.5238 -0.9999 3068313 PK04_095228 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L13 compound treatment 9892360.0 315000.0 0.27 9203160.0 31800.0 0.03 9412440.0 -20585.0 -0.0173095076446698 0.1615 0.5928 3187347 PK04_095229 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(C)C)C(=O)c3ccccc32)c4ccc(CO)cc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L14 compound treatment 9975520.0 398000.0 0.34 9395440.0 224000.0 0.19 9700480.0 267455.0 0.224897467432847 0.4348 0.9667 3068194 PK04_095230 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(C)C)C4=O)c6ccccc6C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L15 mock treatment 9964680.0 387000.0 0.33 9598680.0 427000.0 0.35 9622920.0 189895.0 0.159678841592643 0.4891 0.9555 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L16 mock treatment 9416920.0 -161000.0 -0.14 9360280.0 189000.0 0.16 9120760.0 -312265.0 -0.262577284656925 -0.141 -0.4201 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L17 compound treatment 9390520.0 -187000.0 -0.16 9240040.0 68700.0 0.06 9797000.0 363975.0 0.306059171482569 0.1166 0.3325 3068510 PK04_095231 COc1ccccc1CN2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L18 compound treatment 4180000.0 -5400000.0 -4.65 3171640.0 -6000000.0 -4.98 3315120.0 -6117905.0 -5.1444218298209 -8.5258 -0.9991 3068263 PK04_095232 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3I)Sc4ccc(C)cc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L19 compound treatment 9878440.0 301000.0 0.26 9167680.0 -3640.0 0.0 9096160.0 -336865.0 -0.283262924105984 -0.0159 -0.0415 3067958 PK04_095233 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L20 compound treatment 9634240.0 56400.0 0.05 9304840.0 134000.0 0.11 9333520.0 -99505.0 -0.0836717298121381 0.0437 0.297 3068403 PK04_095234 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L21 compound treatment 8809720.0 -768000.0 -0.66 8731240.0 -440000.0 -0.37 9014360.0 -418665.0 -0.352046879672366 -0.7957 -0.955 3187163 PK04_095235 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L22 compound treatment 9089160.0 -489000.0 -0.42 9598200.0 427000.0 0.35 9027320.0 -405705.0 -0.341149079377252 -0.2353 -0.3637 3186433 PK04_095236 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L23 mock treatment 9316560.0 -261000.0 -0.22 8557640.0 -614000.0 -0.51 9067920.0 -365105.0 -0.307009365489781 -0.601 -0.9456 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 L24 mock treatment 8656360.0 -921000.0 -0.79 8312280.0 -859000.0 -0.71 8718800.0 -714225.0 -0.600577269735937 -1.216 -0.9937 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M01 compound treatment 7916800.0 -1660000.0 -1.43 7677200.0 -1490000.0 -1.24 7559920.0 -1873105.0 -1.57505588131014 -2.4503 -0.9953 3187444 PK04_095237 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M02 compound treatment 8836800.0 -741000.0 -0.64 8565640.0 -606000.0 -0.5 9179120.0 -253905.0 -0.213503548142816 -0.7816 -0.931 3068593 PK04_095238 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NC3CC3)c4ccccc4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M03 compound treatment 8439440.0 -1140000.0 -0.98 7724000.0 -1450000.0 -1.2 8598360.0 -834665.0 -0.701852815071085 -1.6641 -0.9782 3187441 PK04_095239 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M04 compound treatment 8476080.0 -1100000.0 -0.95 8307960.0 -863000.0 -0.72 8739000.0 -694025.0 -0.583591500757441 -1.2979 -0.9804 3068649 PK04_095240 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M05 compound treatment 8742080.0 -836000.0 -0.72 5832640.0 -3340000.0 -2.77 5388120.0 -4044905.0 -3.40127831039412 -3.9781 -0.895 3068152 PK04_095241 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M06 compound treatment 9718120.0 140000.0 0.12 8857920.0 -313000.0 -0.26 9161040.0 -271985.0 -0.228706652258222 -0.2124 -0.5793 3068655 PK04_095242 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M07 compound treatment 9336920.0 -241000.0 -0.21 8895160.0 -276000.0 -0.23 9506280.0 73255.0 0.0615986389366181 -0.2164 -0.6869 3068005 PK04_095243 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M08 compound treatment 9062600.0 -515000.0 -0.44 8122200.0 -1050000.0 -0.87 9287680.0 -145345.0 -0.122217653078189 -0.829 -0.8422 3187084 PK04_095244 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M09 mock treatment 9801360.0 224000.0 0.19 8653840.0 -517000.0 -0.43 9126720.0 -306305.0 -0.257565641928616 -0.2855 -0.5323 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M10 mock treatment 1.005728E7 479000.0 0.41 8481720.0 -690000.0 -0.57 9296800.0 -136225.0 -0.114548830648294 -0.1582 -0.2214 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M11 compound treatment 5798320.0 -3780000.0 -3.25 5934960.0 -3240000.0 -2.68 4853760.0 -4579265.0 -3.85061076145099 -5.6512 -0.9895 3186422 PK04_095245 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M12 compound treatment 9161240.0 -417000.0 -0.36 2658240.0 -6510000.0 -5.4 2515360.0 -6917665.0 -5.81692374062494 -6.6849 -0.8412 3068142 PK04_095246 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M13 mock treatment 9718080.0 140000.0 0.12 9890800.0 719000.0 0.6 9661560.0 228535.0 0.192170431361409 0.5252 0.8226 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M14 mock treatment 9999720.0 422000.0 0.36 9116240.0 -55100.0 -0.05 9277040.0 -155985.0 -0.131164612579733 0.1075 0.2766 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M15 compound treatment 9806080.0 228000.0 0.2 8835200.0 -336000.0 -0.28 9850400.0 417375.0 0.350962144920769 0.1551 0.3168 3068557 PK04_095247 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M16 compound treatment 9182480.0 -395000.0 -0.34 8664360.0 -507000.0 -0.42 9385160.0 -47865.0 -0.0402487045621626 -0.4625 -0.8526 3187170 PK04_095248 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M17 compound treatment 9427000.0 -151000.0 -0.13 8891320.0 -280000.0 -0.23 8774240.0 -658785.0 -0.553958901806838 -0.5289 -0.8606 3187431 PK04_095249 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M18 compound treatment 9988360.0 411000.0 0.35 8804320.0 -367000.0 -0.3 9002760.0 -430265.0 -0.361801083640215 -0.1807 -0.3061 3187074 PK04_095250 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M19 compound treatment 9909320.0 331000.0 0.29 9190920.0 19600.0 0.02 9094760.0 -338265.0 -0.284440155619345 0.0099 0.0245 3068552 PK04_095251 CC(C)NC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M20 compound treatment 9253080.0 -325000.0 -0.28 8864840.0 -306000.0 -0.25 9216160.0 -216865.0 -0.182357365817892 -0.4134 -0.9855 3068014 PK04_095252 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)O)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M21 compound treatment 9326800.0 -251000.0 -0.22 8847480.0 -324000.0 -0.27 9226760.0 -206265.0 -0.173444041502444 -0.38 -0.9846 3187086 PK04_095253 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M22 compound treatment 8459960.0 -1120000.0 -0.96 8416320.0 -755000.0 -0.63 8197720.0 -1235305.0 -1.03874283900893 -1.5168 -0.9797 3187428 PK04_095254 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M23 compound treatment 8921520.0 -656000.0 -0.56 8451600.0 -720000.0 -0.6 9411720.0 -21305.0 -0.0179149409943983 -0.6812 -0.8286 3187081 PK04_095255 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 M24 compound treatment 8609720.0 -968000.0 -0.83 8215200.0 -956000.0 -0.79 8240120.0 -1192905.0 -1.00308954174713 -1.5181 -0.9947 3068003 PK04_095256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N01 compound treatment 7667880.0 -1910000.0 -1.64 7393880.0 -1780000.0 -1.47 7789000.0 -1644025.0 -1.38242717053817 -2.5985 -0.9974 3187360 PK04_095257 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N02 compound treatment 8627200.0 -951000.0 -0.82 8602360.0 -569000.0 -0.47 8917960.0 -515065.0 -0.4331076781638 -0.9949 -0.9575 3068231 PK04_095258 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N03 compound treatment 8818240.0 -760000.0 -0.65 8600600.0 -571000.0 -0.47 1.076036E7 1327335.0 1.11612899341937 -0.0064 -0.0046 3068544 PK04_095259 CC(C)NC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N04 compound treatment 6216400.0 -3360000.0 -2.89 6225040.0 -2950000.0 -2.44 6362360.0 -3070665.0 -2.5820597178392 -4.5721 -0.9975 3187527 PK04_095260 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N05 compound treatment 8432520.0 -1150000.0 -0.99 8468360.0 -703000.0 -0.58 9916400.0 483375.0 0.40646020197922 -0.6711 -0.5522 3187260 PK04_095261 CCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N06 compound treatment 3620520.0 -5960000.0 -5.13 3552480.0 -5620000.0 -4.66 3647000.0 -5786025.0 -4.86535069078214 -8.4603 -0.9992 3186724 PK04_095262 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N07 compound treatment 9629280.0 51500.0 0.04 8453760.0 -718000.0 -0.6 8851160.0 -581865.0 -0.489278438944171 -0.6006 -0.7782 3068501 PK04_095263 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N08 compound treatment 9626320.0 48500.0 0.04 8875080.0 -296000.0 -0.25 8542080.0 -890945.0 -0.7491775219082 -0.5503 -0.697 3186871 PK04_095264 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N09 mock treatment 9003640.0 -574000.0 -0.49 8802200.0 -369000.0 -0.31 9049520.0 -383505.0 -0.322481551093955 -0.6483 -0.9752 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N10 mock treatment 9683720.0 106000.0 0.09 8906680.0 -265000.0 -0.22 9259760.0 -173265.0 -0.145695012973219 -0.1582 -0.5676 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N11 compound treatment 9565520.0 -12300.0 -0.01 8528520.0 -643000.0 -0.53 9324760.0 -108265.0 -0.0910378355671688 -0.3665 -0.6774 3187070 PK04_095265 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N12 compound treatment 3910760.0 -5670000.0 -4.88 3496320.0 -5670000.0 -4.71 3903160.0 -5529865.0 -4.64995095902316 -8.2186 -0.9998 3186804 PK04_095266 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N13 mock treatment 9160240.0 -418000.0 -0.36 8981320.0 -190000.0 -0.16 9278560.0 -154465.0 -0.129886475508084 -0.3735 -0.9035 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N14 mock treatment 9700200.0 122000.0 0.11 8906000.0 -265000.0 -0.22 9242800.0 -190225.0 -0.159956331877936 -0.1586 -0.5437 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N15 compound treatment 5437720.0 -4140000.0 -3.56 5925920.0 -3250000.0 -2.69 1776280.0 -7656745.0 -6.4384010741213 -7.3288 -0.9353 3186424 PK04_095267 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N16 compound treatment 9275000.0 -303000.0 -0.26 8671200.0 -500000.0 -0.41 8683920.0 -749105.0 -0.629907152011675 -0.7537 -0.9444 3068226 PK04_095268 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N17 compound treatment 8888080.0 -690000.0 -0.59 8890920.0 -280000.0 -0.23 8969640.0 -463385.0 -0.389651017727729 -0.702 -0.9395 3068455 PK04_095269 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N18 compound treatment 9129920.0 -448000.0 -0.39 8668760.0 -503000.0 -0.42 8749440.0 -683585.0 -0.574812717186377 -0.7951 -0.9841 3068137 PK04_095270 CN(C)CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N19 compound treatment 9375440.0 -202000.0 -0.17 8898840.0 -272000.0 -0.23 8277000.0 -1156025.0 -0.972077900166595 -0.7923 -0.7821 3068647 PK04_095271 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N20 compound treatment 8420440.0 -1160000.0 -1.0 8388640.0 -783000.0 -0.65 8671840.0 -761185.0 -0.640064978212676 -1.3195 -0.9772 3186492 PK04_095272 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N21 compound treatment 8785800.0 -792000.0 -0.68 7889120.0 -1280000.0 -1.06 9055200.0 -377825.0 -0.317705354668319 -1.1911 -0.9143 3067959 PK04_095273 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N22 compound treatment 8248880.0 -1330000.0 -1.14 8338720.0 -833000.0 -0.69 8632160.0 -800865.0 -0.673431082819939 -1.4479 -0.9677 3187526 PK04_095274 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)O)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N23 compound treatment 8907000.0 -671000.0 -0.58 8635880.0 -535000.0 -0.44 8841200.0 -591825.0 -0.497653600282083 -0.8771 -0.9942 3068468 PK04_095275 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 N24 compound treatment 8142600.0 -1440000.0 -1.24 8260960.0 -910000.0 -0.76 8349920.0 -1083105.0 -0.910760955913531 -1.675 -0.9793 3068222 PK04_095276 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O01 compound treatment 6854600.0 -2720000.0 -2.34 7189200.0 -1980000.0 -1.64 7211360.0 -2221665.0 -1.86815289295095 -3.3811 -0.989 3068590 PK04_095277 CC(C)NC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O02 compound treatment 4095520.0 -5480000.0 -4.72 4705440.0 -4470000.0 -3.7 4626760.0 -4806265.0 -4.04149044254596 -7.1964 -0.9949 3067977 PK04_095278 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O03 compound treatment 8807200.0 -771000.0 -0.66 8470360.0 -701000.0 -0.58 8750160.0 -682865.0 -0.574207283836649 -1.0502 -0.9978 3068512 PK04_095279 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O04 compound treatment 8603840.0 -974000.0 -0.84 8369720.0 -802000.0 -0.66 8715080.0 -717945.0 -0.603705342042867 -1.2164 -0.9901 3068637 PK04_095280 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O05 compound treatment 8494920.0 -1080000.0 -0.93 8321520.0 -850000.0 -0.7 8605960.0 -827065.0 -0.695462129712839 -1.3466 -0.9903 3068459 PK04_095281 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O06 compound treatment 9211000.0 -367000.0 -0.32 9580840.0 410000.0 0.34 9692960.0 259935.0 0.218574052446793 0.1401 0.2732 3187520 PK04_095282 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O07 compound treatment 8929280.0 -649000.0 -0.56 9019240.0 -152000.0 -0.13 8999080.0 -433945.0 -0.36489552076105 -0.6058 -0.8926 3186989 PK04_095283 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O08 compound treatment 8628360.0 -949000.0 -0.82 8404400.0 -767000.0 -0.64 8574200.0 -858825.0 -0.722168467473087 -1.256 -0.9948 3187364 PK04_095284 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O09 compound treatment 8153560.0 -1420000.0 -1.23 8078680.0 -1090000.0 -0.91 8525080.0 -907945.0 -0.763472475999013 -1.6718 -0.9805 3068604 PK04_095285 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O10 compound treatment 9093560.0 -484000.0 -0.42 9150840.0 -20500.0 -0.02 9573760.0 140735.0 0.118341197880622 -0.1821 -0.42 3187362 PK04_095286 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O11 mock treatment 9420600.0 -157000.0 -0.14 9492360.0 321000.0 0.27 9108280.0 -324745.0 -0.273071462718886 -0.082 -0.2026 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O12 mock treatment 1.002188E7 444000.0 0.38 9150280.0 -21000.0 -0.02 9267120.0 -165905.0 -0.139506138731549 0.13 0.3193 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O13 compound treatment 8787040.0 -791000.0 -0.68 8523000.0 -648000.0 -0.54 8402520.0 -1030505.0 -0.86653068619725 -1.2037 -0.9818 3068644 PK04_095287 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O14 compound treatment 9437600.0 -140000.0 -0.12 9200080.0 28800.0 0.02 9654640.0 221615.0 0.186351544166796 0.0517 0.2315 3068464 PK04_095288 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O15 compound treatment 3381960.0 -6200000.0 -5.33 3093480.0 -6080000.0 -5.04 3165680.0 -6267345.0 -5.27008288507567 -9.0323 -0.9997 3187516 PK04_095289 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O16 compound treatment 9391320.0 -187000.0 -0.16 9550200.0 379000.0 0.31 9237920.0 -195105.0 -0.164059824581651 -0.0059 -0.0152 3187164 PK04_095290 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O17 compound treatment 8760960.0 -817000.0 -0.7 8907840.0 -263000.0 -0.22 9257280.0 -175745.0 -0.147780394511172 -0.6174 -0.8222 3187177 PK04_095291 CC(C)CNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O18 compound treatment 8096600.0 -1480000.0 -1.27 8917760.0 -254000.0 -0.21 8812600.0 -620425.0 -0.521702758340745 -1.1587 -0.8315 3068546 PK04_095292 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O19 compound treatment 8941120.0 -637000.0 -0.55 9015040.0 -156000.0 -0.13 9245760.0 -187265.0 -0.157467328106829 -0.4821 -0.8246 3187256 PK04_095293 CC(C)CNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O20 compound treatment 8896160.0 -682000.0 -0.59 8797360.0 -374000.0 -0.31 8976440.0 -456585.0 -0.383933036091403 -0.7395 -0.9645 3187088 PK04_095294 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O21 compound treatment 7831600.0 -1750000.0 -1.5 8323240.0 -848000.0 -0.7 8466480.0 -966545.0 -0.812748023629698 -1.7431 -0.9434 3186494 PK04_095295 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(C)C)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O22 compound treatment 8549720.0 -1030000.0 -0.88 8747520.0 -424000.0 -0.35 8550840.0 -882185.0 -0.741811416153169 -1.1421 -0.9463 3187161 PK04_095296 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O23 compound treatment 8943640.0 -634000.0 -0.55 8773120.0 -398000.0 -0.33 8622160.0 -810865.0 -0.681839879343946 -0.8995 -0.9633 3187267 PK04_095297 CC(C)CNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 O24 compound treatment 7769360.0 -1810000.0 -1.56 8257240.0 -914000.0 -0.76 8224600.0 -1208425.0 -1.01613999395239 -1.9231 -0.9579 3068502 PK04_095298 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P01 compound treatment 6911160.0 -2670000.0 -2.3 6704760.0 -2470000.0 -2.05 7238000.0 -2195025.0 -1.84575185901099 -3.572 -0.9961 3068591 PK04_095299 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2CC4(CC5CC6CC(C5)C4)C6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P02 compound treatment 8159800.0 -1420000.0 -1.22 7872680.0 -1300000.0 -1.08 8293440.0 -1139585.0 -0.958253838681126 -1.8798 -0.9952 3187521 PK04_095300 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P03 compound treatment 8407560.0 -1170000.0 -1.01 7630240.0 -1540000.0 -1.28 8084240.0 -1348785.0 -1.13416586196337 -1.9744 -0.9953 3186990 PK04_095301 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P04 compound treatment 8219720.0 -1360000.0 -1.17 8184320.0 -987000.0 -0.82 8224720.0 -1208305.0 -1.01603908839411 -1.7342 -0.9899 3186985 PK04_095302 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P05 compound treatment 1908400.0 -7670000.0 -6.6 2350480.0 -6820000.0 -5.66 2842720.0 -6590305.0 -5.54165337761502 -10.2772 -0.9968 3067579 PK04_095303 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-])c(I)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P06 compound treatment 8795280.0 -783000.0 -0.67 8377840.0 -793000.0 -0.66 8696920.0 -736105.0 -0.618975716530465 -1.1262 -0.9994 3186975 PK04_095304 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P07 compound treatment 1.052448E7 947000.0 0.81 9308000.0 137000.0 0.11 8068240.0 -1364785.0 -1.14761993640178 -0.1267 -0.0898 3068548 PK04_095305 CC(C)CNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P08 compound treatment 8497000.0 -1080000.0 -0.93 9903480.0 732000.0 0.61 8566440.0 -866585.0 -0.728693693575717 -0.6071 -0.4569 3067563 PK04_095306 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CCN5CCOCC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P09 compound treatment 7836680.0 -1740000.0 -1.5 9788800.0 617000.0 0.51 8154560.0 -1278465.0 -1.07503520480654 -1.1901 -0.6218 3067961 PK04_095307 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P10 compound treatment 8445960.0 -1130000.0 -0.97 8464720.0 -707000.0 -0.59 8186480.0 -1246545.0 -1.04819432630191 -1.506 -0.9739 3068015 PK04_095308 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P11 mock treatment 8999560.0 -578000.0 -0.5 8809240.0 -362000.0 -0.3 8722760.0 -710265.0 -0.597247386312429 -0.8056 -0.9666 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P12 mock treatment 8647080.0 -931000.0 -0.8 8179560.0 -992000.0 -0.82 8515840.0 -917185.0 -0.771242203987196 -1.3828 -0.9997 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P13 compound treatment 7907240.0 -1670000.0 -1.44 7215760.0 -1960000.0 -1.62 7624560.0 -1808465.0 -1.52070142057895 -2.6447 -0.9988 3187510 PK04_095309 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P14 compound treatment 5553680.0 -4020000.0 -3.46 5346440.0 -3820000.0 -3.17 5518400.0 -3914625.0 -3.29172850927935 -5.732 -0.9994 3186495 PK04_095310 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCN5CCOCC5)c6ccccc6C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P15 compound treatment 9152280.0 -426000.0 -0.37 8622480.0 -549000.0 -0.46 8661080.0 -771945.0 -0.649112843272509 -0.8491 -0.9722 3187437 PK04_095311 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P16 compound treatment 9032080.0 -546000.0 -0.47 8255000.0 -916000.0 -0.76 8864720.0 -568305.0 -0.477876110857617 -0.9859 -0.973 3186625 PK04_095312 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C(C)C)C4=O)c6ccccc6C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P17 compound treatment 8360440.0 -1220000.0 -1.05 8472560.0 -699000.0 -0.58 8349480.0 -1083545.0 -0.911130942960587 -1.4656 -0.9741 3068541 PK04_095313 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P18 compound treatment 8974760.0 -603000.0 -0.52 8526480.0 -645000.0 -0.53 8629960.0 -803065.0 -0.67528101805522 -0.9984 -0.9927 3186878 PK04_095314 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NC6CC6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P19 compound treatment 5328760.0 -4250000.0 -3.66 6069440.0 -3100000.0 -2.57 5635120.0 -3797905.0 -3.19358103625113 -5.4408 -0.9902 3187513 PK04_095315 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P20 compound treatment 3677920.0 -5900000.0 -5.08 3532240.0 -5640000.0 -4.68 3512400.0 -5920625.0 -4.97853309199528 -8.5068 -0.9994 3068271 PK04_095316 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCc6ccccc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P21 compound treatment 3195600.0 -6380000.0 -5.49 2971560.0 -6200000.0 -5.14 3105200.0 -6327825.0 -5.32093928645287 -9.2127 -0.9996 3068008 PK04_095317 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P22 compound treatment 3364920.0 -6210000.0 -5.35 3106400.0 -6060000.0 -5.03 3152280.0 -6280745.0 -5.28135067241784 -9.0411 -0.9997 3068262 PK04_095318 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P23 compound treatment 7934360.0 -1640000.0 -1.41 7585360.0 -1590000.0 -1.32 7821560.0 -1611465.0 -1.355048129056 -2.3586 -0.9996 3068469 PK04_095319 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2095 P24 compound treatment 2931960.0 -6650000.0 -5.72 2865920.0 -6310000.0 -5.23 2997960.0 -6435065.0 -5.41111522037633 -9.4464 -0.9993 3186794 PK04_095320 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A01 compound treatment 4771560.0 -4610000.0 -3.97 4629360.0 -5110000.0 -4.24 4494720.0 -4819211.42857143 -4.05237683090294 -7.0779 -0.9996 3186490 PK04_096001 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A02 compound treatment 7677000.0 -1710000.0 -1.47 7829760.0 -1910000.0 -1.58 6820280.0 -2493651.42857143 -2.09686074646581 -2.9723 -0.9875 3186641 PK04_096002 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A03 compound treatment 2941040.0 -6440000.0 -5.54 3258640.0 -6480000.0 -5.38 2985680.0 -6328251.42857143 -5.32129786156179 -9.3766 -0.9998 3068261 PK04_096003 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A04 compound treatment 8145080.0 -1240000.0 -1.06 8016600.0 -1720000.0 -1.43 6934280.0 -2379651.42857143 -2.00100046609213 -2.5949 -0.9685 3186971 PK04_096004 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A05 compound treatment 7732840.0 -1650000.0 -1.42 9032800.0 -706000.0 -0.59 7436440.0 -1877491.42857143 -1.57874433984256 -2.0693 -0.9395 3186883 PK04_096005 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A06 compound treatment 2771520.0 -6610000.0 -5.69 3083920.0 -6650000.0 -5.52 2976880.0 -6337051.42857143 -5.32869760250292 -9.5488 -0.9996 3068309 PK04_096006 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A07 compound treatment 3284400.0 -6100000.0 -5.25 3153240.0 -6590000.0 -5.46 3046680.0 -6267251.42857143 -5.27000420276534 -9.2268 -0.9998 3186716 PK04_096007 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A08 compound treatment 7983720.0 -1400000.0 -1.2 7746200.0 -1990000.0 -1.65 7103800.0 -2210131.42857143 -1.85845454741715 -2.7223 -0.9852 3068367 PK04_096008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)Sc6ccc(C)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A09 compound treatment 8155600.0 -1230000.0 -1.06 8819720.0 -919000.0 -0.76 7596960.0 -1716971.42857143 -1.44376633803919 -1.8833 -0.9686 3068224 PK04_096009 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A10 compound treatment 8359880.0 -1020000.0 -0.88 8935400.0 -803000.0 -0.67 7827520.0 -1486411.42857143 -1.24989312538167 -1.6145 -0.9682 3186633 PK04_096010 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5C(F)(F)F)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A11 compound treatment 8311080.0 -1070000.0 -0.92 9082600.0 -656000.0 -0.54 7222040.0 -2091891.42857143 -1.75902893731728 -1.8622 -0.9043 3186986 PK04_096011 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A12 compound treatment 8389680.0 -993000.0 -0.85 8959720.0 -779000.0 -0.65 8170560.0 -1143371.42857143 -0.96143776942211 -1.4215 -0.9875 3186640 PK04_096012 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A13 mock treatment 8827080.0 -555000.0 -0.48 8955560.0 -783000.0 -0.65 7703800.0 -1610131.42857143 -1.35392675597669 -1.4327 -0.9091 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A14 mock treatment 7864360.0 -1520000.0 -1.31 9333840.0 -405000.0 -0.34 7064240.0 -2249691.42857143 -1.89171974646612 -2.0404 -0.8782 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A15 compound treatment 8363400.0 -1020000.0 -0.88 8778320.0 -960000.0 -0.8 7377120.0 -1936811.42857143 -1.62862532082297 -1.9066 -0.9467 3186881 PK04_096013 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A16 compound treatment 3501440.0 -5880000.0 -5.06 3395040.0 -6340000.0 -5.26 3167360.0 -6146571.42857143 -5.16852684631362 -8.9446 -0.9999 3186790 PK04_096014 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A17 compound treatment 8404960.0 -977000.0 -0.84 8554360.0 -1180000.0 -0.98 7956120.0 -1357811.42857143 -1.14175600208293 -1.7122 -0.9924 3186485 PK04_096015 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A18 compound treatment 2572440.0 -6810000.0 -5.86 3138280.0 -6600000.0 -5.48 2268920.0 -7045011.42857143 -5.92400676121656 -9.9654 -0.9994 3186802 PK04_096016 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A19 compound treatment 8004080.0 -1380000.0 -1.19 8366040.0 -1370000.0 -1.14 7694440.0 -1619491.42857143 -1.36179738952316 -2.1286 -0.997 3068405 PK04_096017 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A20 compound treatment 7837320.0 -1550000.0 -1.33 8063240.0 -1680000.0 -1.39 7360160.0 -1953771.42857143 -1.64288663972769 -2.5188 -0.9957 3068141 PK04_096018 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A21 compound treatment 7740680.0 -1640000.0 -1.41 8593920.0 -1140000.0 -0.95 7453360.0 -1860571.42857143 -1.56451665612394 -2.2674 -0.9806 3186624 PK04_096019 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5OC)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A22 compound treatment 7934480.0 -1450000.0 -1.25 8206240.0 -1530000.0 -1.27 7266320.0 -2047611.42857143 -1.72179478630898 -2.4475 -0.9883 3068200 PK04_096020 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCCN(C)C)C4=O)c6ccccc6C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A23 compound treatment 9404920.0 22500.0 0.02 7876880.0 -1860000.0 -1.54 7659600.0 -1654331.42857143 -1.3910936366128 -1.6837 -0.81 3068358 PK04_096021 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 A24 compound treatment 7768600.0 -1610000.0 -1.39 7117480.0 -2620000.0 -2.17 7146720.0 -2167211.42857143 -1.82236399273611 -3.1095 -0.9844 3068371 PK04_096022 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B01 compound treatment 7869160.0 -1510000.0 -1.3 8230280.0 -1510000.0 -1.25 7932280.0 -1381651.42857143 -1.16180257299616 -2.1452 -0.9989 3187511 PK04_096023 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCC(F)(F)F)c3ccc(cc3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B02 compound treatment 8727080.0 -655000.0 -0.56 9013880.0 -725000.0 -0.6 8521280.0 -792651.428571429 -0.666524457732113 -1.0576 -0.9976 3187030 PK04_096024 OCCCc1cc[n+](Cc2cccc(OC(F)(F)F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B03 compound treatment 9128520.0 -254000.0 -0.22 8973320.0 -765000.0 -0.63 8382120.0 -931811.428571429 -0.783541270160204 -0.9451 -0.9159 3187169 PK04_096025 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B04 compound treatment 9300120.0 -82300.0 -0.07 9723840.0 -14900.0 -0.01 8776120.0 -537811.428571429 -0.452234687114302 -0.3091 -0.6751 3068853 PK04_096026 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B05 compound treatment 8916240.0 -466000.0 -0.4 9005080.0 -734000.0 -0.61 8341880.0 -972051.428571429 -0.817378267372811 -1.0549 -0.9632 3068457 PK04_096027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B06 compound treatment 8460800.0 -922000.0 -0.79 9337080.0 -402000.0 -0.33 8442320.0 -871611.428571429 -0.732920315085678 -1.0735 -0.9498 3068854 PK04_096028 C[n+]1ccc2ccc(O)cc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B07 compound treatment 9118200.0 -264000.0 -0.23 9626160.0 -113000.0 -0.09 9179320.0 -134611.428571429 -0.113192011266314 -0.2506 -0.9258 3187352 PK04_096029 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCCN4CCOCC4)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B08 compound treatment 9257080.0 -125000.0 -0.11 9448200.0 -291000.0 -0.24 8965720.0 -348211.428571429 -0.292803905019117 -0.3705 -0.9396 3187112 PK04_096030 COc1cc2CC[N+](=Cc2cc1O)Cc3cc4OCOc4cc3Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B09 compound treatment 9188840.0 -194000.0 -0.17 9663440.0 -75300.0 -0.06 9017200.0 -296731.428571429 -0.249515420513526 -0.2763 -0.9016 3068505 PK04_096031 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B10 compound treatment 9372640.0 -9800.0 -0.01 9538600.0 -200000.0 -0.17 9367920.0 53988.5714285709 0.0453978911764706 -0.0745 -0.4324 3068855 PK04_096032 C[n+]1ccc(CCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B11 compound treatment 8903040.0 -479000.0 -0.41 8947720.0 -791000.0 -0.66 8587720.0 -726211.428571429 -0.610656413626606 -0.9696 -0.9826 3068374 PK04_096033 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B12 compound treatment 4079880.0 -5300000.0 -4.56 5475360.0 -4260000.0 -3.54 5999320.0 -3314611.42857143 -2.78718930590075 -6.2859 -0.9805 3187113 PK04_096034 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C=C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B13 mock treatment 9535640.0 153000.0 0.13 1.020724E7 469000.0 0.39 9745120.0 431188.571428571 0.362577696062039 0.5099 0.931 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B14 mock treatment 9271640.0 -111000.0 -0.1 9827000.0 88300.0 0.07 9181600.0 -132331.428571429 -0.11127480565884 -0.077 -0.4702 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B15 compound treatment 9369120.0 -13300.0 -0.01 9696640.0 -42100.0 -0.03 9736760.0 422828.571428571 0.355547942167969 0.1785 0.4994 3187255 PK04_096035 COCCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B16 compound treatment 8914880.0 -468000.0 -0.4 9317800.0 -421000.0 -0.35 8852040.0 -461891.428571429 -0.388395103904036 -0.6582 -0.9982 3068856 PK04_096036 Oc1ccc2cc[n+](Cc3sc4ccccc4c3Cl)cc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B17 compound treatment 8668320.0 -714000.0 -0.61 9344240.0 -394000.0 -0.33 8588480.0 -725451.428571429 -0.610017345090782 -0.896 -0.9679 3068608 PK04_096037 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B18 compound treatment 2044800.0 -7340000.0 -6.32 2387440.0 -7350000.0 -6.1 2420800.0 -6893131.42857143 -5.79629395960993 -10.5134 -0.9994 3187114 PK04_096038 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C5CC5)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B19 compound treatment 9089800.0 -293000.0 -0.25 9439480.0 -299000.0 -0.25 8373480.0 -940451.428571429 -0.790806470356946 -0.7453 -0.8604 3187171 PK04_096039 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B20 compound treatment 8554920.0 -828000.0 -0.71 9321080.0 -418000.0 -0.35 8422000.0 -891931.428571429 -0.750006989622461 -1.0442 -0.9573 3068857 PK04_096040 OCCCc1cc[n+](Cc2ccc(o2)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B21 compound treatment 8750920.0 -632000.0 -0.54 9616520.0 -122000.0 -0.1 8572160.0 -741771.428571429 -0.623740501017962 -0.7324 -0.8788 3068424 PK04_096041 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B22 compound treatment 7864920.0 -1520000.0 -1.31 9433800.0 -305000.0 -0.25 8339440.0 -974491.428571429 -0.819430013724668 -1.3732 -0.8789 3187115 PK04_096042 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B23 compound treatment 8297360.0 -1090000.0 -0.93 9008840.0 -730000.0 -0.61 8355640.0 -958291.428571429 -0.805807763355776 -1.354 -0.9854 3187072 PK04_096043 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 B24 compound treatment 7938520.0 -1440000.0 -1.24 8052120.0 -1690000.0 -1.4 7153800.0 -2160131.42857143 -1.81641056479711 -2.574 -0.987 3187116 PK04_096044 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C01 compound treatment 8516360.0 -866000.0 -0.75 9278000.0 -461000.0 -0.38 8116040.0 -1197891.42857143 -1.007282528071 -1.2326 -0.9408 3068218 PK04_096045 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C02 compound treatment 9141120.0 -241000.0 -0.21 8958600.0 -780000.0 -0.65 8499760.0 -814171.428571429 -0.684620187851778 -0.8888 -0.9213 3186566 PK04_096046 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C03 compound treatment 8805320.0 -577000.0 -0.5 8685120.0 -1050000.0 -0.87 8376000.0 -937931.428571429 -0.788687453632896 -1.2467 -0.9757 3186549 PK04_096047 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C04 compound treatment 3765160.0 -5620000.0 -4.83 3748720.0 -5990000.0 -4.97 3323280.0 -5990651.42857143 -5.03741689091129 -8.5685 -0.9999 3186726 PK04_096048 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C05 compound treatment 3994800.0 -5390000.0 -4.64 3956360.0 -5780000.0 -4.8 3752120.0 -5561811.42857143 -4.67681406077575 -8.1467 -0.9999 3186792 PK04_096049 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C06 compound treatment 9566640.0 184000.0 0.16 1.004192E7 303000.0 0.25 9580040.0 266108.571428571 0.223765283043721 0.3659 0.9834 3186987 PK04_096050 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C07 compound treatment 7722800.0 -1660000.0 -1.43 4627760.0 -5110000.0 -4.24 4410280.0 -4903651.42857143 -4.12338070875166 -5.6532 -0.9291 3068275 PK04_096051 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C08 compound treatment 9279760.0 -103000.0 -0.09 9810120.0 71400.0 0.06 9666840.0 352908.571428571 0.296753636872107 0.1545 0.4901 3186560 PK04_096052 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C09 compound treatment 9009760.0 -373000.0 -0.32 6903400.0 -2840000.0 -2.35 7874920.0 -1439011.42857143 -1.21003542985787 -2.2418 -0.8414 3068147 PK04_096053 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C10 compound treatment 9751280.0 369000.0 0.32 9251800.0 -487000.0 -0.4 9651120.0 337188.571428571 0.283535008736367 0.1138 0.1939 3186976 PK04_096054 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C11 mock treatment 9001040.0 -381000.0 -0.33 9344560.0 -394000.0 -0.33 9001240.0 -312691.428571429 -0.262935859765842 -0.5301 -0.9951 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C12 mock treatment 1.046948E7 1090000.0 0.94 1.015688E7 418000.0 0.35 9754360.0 440428.571428571 0.370347424050222 0.9542 0.8966 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C13 compound treatment 9402080.0 19600.0 0.02 9866520.0 128000.0 0.11 9295640.0 -18291.4285714291 -0.0153808900990567 0.0621 0.5725 3186974 PK04_096055 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C14 compound treatment 9193960.0 -188000.0 -0.16 1.052784E7 789000.0 0.65 9894560.0 580628.571428571 0.48823875131681 0.5662 0.68 3186876 PK04_096056 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C15 mock treatment 9112920.0 -270000.0 -0.23 9951520.0 213000.0 0.18 1.002192E7 707988.571428571 0.595333183846571 0.3117 0.4702 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C16 mock treatment 9412720.0 30300.0 0.03 9868440.0 130000.0 0.11 8534960.0 -778971.428571429 -0.655021224087271 -0.301 -0.4531 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C17 compound treatment 9061480.0 -321000.0 -0.28 9815560.0 76800.0 0.06 9019160.0 -294771.428571429 -0.24786729639482 -0.2658 -0.7058 3186553 PK04_096057 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C18 compound treatment 9766640.0 384000.0 0.33 9498320.0 -240000.0 -0.2 9456280.0 142348.571428571 0.119698017262602 0.1449 0.3583 3186634 PK04_096058 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C19 compound treatment 8784920.0 -598000.0 -0.51 1.022992E7 491000.0 0.41 9256640.0 -57291.4285714291 -0.0481751965426866 -0.0895 -0.136 3186638 PK04_096059 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C20 compound treatment 9394520.0 12100.0 0.01 1.001768E7 279000.0 0.23 8863920.0 -450011.428571429 -0.378405453633515 -0.0789 -0.1778 3068219 PK04_096060 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C21 compound treatment 8460680.0 -922000.0 -0.79 8844240.0 -894000.0 -0.74 8695680.0 -618251.428571429 -0.51987504635342 -1.1866 -0.9853 3068151 PK04_096061 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C22 compound treatment 8594960.0 -787000.0 -0.68 9619240.0 -119000.0 -0.1 9273600.0 -40331.4285714291 -0.0339138776379696 -0.4681 -0.6826 3068158 PK04_096062 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C23 compound treatment 3714760.0 -5670000.0 -4.88 3618560.0 -6120000.0 -5.08 3634840.0 -5679091.42857143 -4.77543242640931 -8.5046 -0.9997 3186800 PK04_096063 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 C24 compound treatment 8789360.0 -593000.0 -0.51 8641200.0 -1100000.0 -0.91 8191760.0 -1122171.42857143 -0.943611120791213 -1.3652 -0.9702 3068376 PK04_096064 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D01 compound treatment 8857920.0 -525000.0 -0.45 8798680.0 -940000.0 -0.78 8817560.0 -496371.428571429 -0.417388634318815 -0.9518 -0.9585 3068407 PK04_096065 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D02 compound treatment 8536280.0 -846000.0 -0.73 8973760.0 -765000.0 -0.63 8156960.0 -1156971.42857143 -0.97287373269476 -1.3485 -0.9836 3187117 PK04_096066 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D03 compound treatment 9532240.0 150000.0 0.13 9751840.0 13100.0 0.01 8961440.0 -352491.428571429 -0.296402869931392 -0.0904 -0.2796 3187274 PK04_096067 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D04 compound treatment 7467800.0 -1910000.0 -1.65 7117040.0 -2620000.0 -2.17 7932440.0 -1381491.42857143 -1.16166803225178 -2.8777 -0.9704 3068858 PK04_096068 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C=C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D05 compound treatment 9684160.0 302000.0 0.26 9318680.0 -420000.0 -0.35 9207320.0 -106611.428571429 -0.0896473809990923 -0.103 -0.2322 3187075 PK04_096069 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D06 compound treatment 9817360.0 435000.0 0.37 9898640.0 160000.0 0.13 9937000.0 623068.571428571 0.523925683764698 0.5952 0.9053 3187118 PK04_096070 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D07 compound treatment 9523200.0 141000.0 0.12 1.025052E7 512000.0 0.42 9466920.0 152988.571428571 0.128644976764146 0.3893 0.8466 3068634 PK04_096071 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D08 compound treatment 9446520.0 64100.0 0.06 9760920.0 22200.0 0.02 9420360.0 106428.571428571 0.0894936201483667 0.0941 0.8821 3068859 PK04_096072 OCc1ccc(cc1)c2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D09 compound treatment 6451080.0 -2930000.0 -2.52 7678200.0 -2060000.0 -1.71 6096360.0 -3217571.42857143 -2.70559034443178 -4.0055 -0.9829 3067975 PK04_096073 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D10 compound treatment 9649560.0 267000.0 0.23 9887880.0 149000.0 0.12 9902320.0 588388.571428571 0.49476397741944 0.4898 0.8756 3068860 PK04_096074 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D11 mock treatment 9478000.0 95600.0 0.08 1.015724E7 419000.0 0.35 9266360.0 -47571.4285714291 -0.0400018463213511 0.2248 0.6262 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D12 mock treatment 9536040.0 154000.0 0.13 9838000.0 99300.0 0.08 9995600.0 681668.571428571 0.573201231395383 0.4548 0.7657 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D13 compound treatment 9560360.0 178000.0 0.15 9904360.0 166000.0 0.14 9170160.0 -143771.428571429 -0.120894468882305 0.0979 0.4104 3187429 PK04_096075 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D14 compound treatment 1.00112E7 629000.0 0.54 9414320.0 -324000.0 -0.27 9460040.0 146108.571428571 0.122859724755629 0.228 0.3697 3187119 PK04_096076 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D15 mock treatment 9844280.0 462000.0 0.4 9977240.0 239000.0 0.2 9692760.0 378828.571428571 0.318549237462335 0.5276 0.9656 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D16 mock treatment 9097560.0 -285000.0 -0.25 9933800.0 195000.0 0.16 9586560.0 272628.571428571 0.229247818377374 0.0842 0.226 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D17 compound treatment 9815600.0 433000.0 0.37 1.025236E7 514000.0 0.43 1.015352E7 839588.571428571 0.705992946102512 0.8688 0.9601 3187348 PK04_096077 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D18 compound treatment 9672960.0 291000.0 0.25 9385720.0 -353000.0 -0.29 9748160.0 434228.571428571 0.365133970205338 0.1861 0.3507 3068861 PK04_096078 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C4CC4)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D19 compound treatment 9769320.0 387000.0 0.33 1.001884E7 280000.0 0.23 1.041796E7 1104028.57142857 0.92835516138337 0.8624 0.8511 3187354 PK04_096079 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D20 compound treatment 9543360.0 161000.0 0.14 1.01586E7 420000.0 0.35 9214760.0 -99171.4285714291 -0.0833912363852306 0.2329 0.6065 3187120 PK04_096080 OCc1ccc(cc1)c2cc[n+](Cc3sc4ccccc4c3Cl)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D21 compound treatment 9474360.0 91900.0 0.08 9827680.0 88900.0 0.07 9430080.0 116148.571428571 0.0976669703697021 0.1447 0.9926 3187433 PK04_096081 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D22 compound treatment 9115640.0 -267000.0 -0.23 9496600.0 -242000.0 -0.2 9789200.0 475268.571428571 0.399643671139865 -0.0178 -0.0354 3068862 PK04_096082 COc1cc2CCN(C)C(C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D23 compound treatment 8867000.0 -515000.0 -0.44 9583120.0 -156000.0 -0.13 8941760.0 -372171.428571429 -0.31295138149064 -0.5113 -0.9163 3068462 PK04_096083 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 D24 compound treatment 8193360.0 -1190000.0 -1.02 7915720.0 -1820000.0 -1.51 8441960.0 -871971.428571429 -0.733223031760542 -1.8873 -0.9591 3187121 PK04_096084 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E01 mock treatment 8740520.0 -642000.0 -0.55 8505880.0 -1230000.0 -1.02 8616280.0 -697651.428571429 -0.586640890754041 -1.2481 -0.9586 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E02 mock treatment 9157840.0 -225000.0 -0.19 9634280.0 -104000.0 -0.09 9173400.0 -140531.428571429 -0.118170018808526 -0.2299 -0.9476 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E03 compound treatment 3624680.0 -5760000.0 -4.96 3768200.0 -5970000.0 -4.95 3773600.0 -5540331.42857143 -4.65875196584218 -8.4103 -0.9996 3186708 PK04_096085 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E04 compound treatment 8525000.0 -857000.0 -0.74 7810600.0 -1930000.0 -1.6 8319880.0 -994051.428571429 -0.835877619725627 -1.8321 -0.9396 3186710 PK04_096086 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E05 compound treatment 9092840.0 -290000.0 -0.25 9567480.0 -171000.0 -0.14 9087040.0 -226891.428571429 -0.190788385589856 -0.3361 -0.9754 3186888 PK04_096087 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E06 compound treatment 1.025236E7 870000.0 0.75 9709240.0 -29500.0 -0.02 9528440.0 214508.571428571 0.180375892979841 0.5223 0.6778 3186565 PK04_096088 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E07 compound treatment 9591080.0 209000.0 0.18 1.03214E7 583000.0 0.48 9665600.0 351668.571428571 0.29571094610313 0.5535 0.9311 3186983 PK04_096089 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E08 compound treatment 9420480.0 38000.0 0.03 1.029324E7 555000.0 0.46 9857960.0 544028.571428571 0.457462556038942 0.5486 0.8446 3067581 PK04_096090 CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E09 mock treatment 9628280.0 246000.0 0.21 1.022332E7 485000.0 0.4 9981560.0 667628.571428571 0.561395281075676 0.6784 0.9393 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E10 mock treatment 1.020644E7 824000.0 0.71 1.023456E7 496000.0 0.41 1.008664E7 772708.571428571 0.649754914949949 1.0221 0.977 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E11 compound treatment 6478280.0 -2900000.0 -2.5 3801200.0 -5940000.0 -4.93 3599600.0 -5714331.42857143 -4.80506502535991 -7.0611 -0.9645 3186717 PK04_096091 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E12 compound treatment 1.006024E7 678000.0 0.58 1.063268E7 894000.0 0.74 9962880.0 648948.571428571 0.54568764916883 1.08 0.9909 3068221 PK04_096092 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E13 compound treatment 3896200.0 -5490000.0 -4.72 4425760.0 -5310000.0 -4.41 4098720.0 -5215211.42857143 -4.38536517325364 -7.8026 -0.9994 3068273 PK04_096093 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E14 compound treatment 9875000.0 493000.0 0.42 1.103004E7 1290000.0 1.07 1.01796E7 865668.571428571 0.727923087437124 1.2835 0.9418 3068377 PK04_096094 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E15 compound treatment 9702200.0 320000.0 0.28 9690280.0 -48500.0 -0.04 9854960.0 541028.571428571 0.454939917081739 0.3983 0.747 3068408 PK04_096095 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E16 compound treatment 9713880.0 331000.0 0.29 1.017072E7 432000.0 0.36 9564440.0 250508.571428571 0.210647560466269 0.4932 0.9783 3186635 PK04_096096 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E17 mock treatment 9686520.0 304000.0 0.26 1.015888E7 420000.0 0.35 9502120.0 188188.571428571 0.158243940528653 0.4437 0.9569 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E18 mock treatment 9995680.0 613000.0 0.53 9612560.0 -126000.0 -0.1 9351240.0 37308.5714285709 0.0313720185744258 0.2624 0.4868 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E19 compound treatment 6459560.0 -2920000.0 -2.52 3613200.0 -6130000.0 -5.08 4172000.0 -5141931.42857143 -4.32374551232571 -6.8825 -0.9652 3186791 PK04_096097 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E20 compound treatment 9617760.0 235000.0 0.2 9149640.0 -589000.0 -0.49 9174080.0 -139851.428571429 -0.117598220644894 -0.2331 -0.4302 3068233 PK04_096098 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E21 compound treatment 3988080.0 -5390000.0 -4.64 3695880.0 -6040000.0 -5.01 3467640.0 -5846291.42857143 -4.91602750429072 -8.4129 -0.9995 3186719 PK04_096099 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)Sc6ccc(C)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E22 compound treatment 4711840.0 -4670000.0 -4.02 4075840.0 -5660000.0 -4.7 3455320.0 -5858611.42857143 -4.92638714160829 -7.8773 -0.9964 3186789 PK04_096100 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E23 compound treatment 3417480.0 -5960000.0 -5.13 3454960.0 -6280000.0 -5.21 3392400.0 -5921531.42857143 -4.97929528933735 -8.8484 -0.9998 3186803 PK04_096101 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 E24 compound treatment 8461880.0 -921000.0 -0.79 7678520.0 -2060000.0 -1.71 7333480.0 -1980451.42857143 -1.66532130885374 -2.4056 -0.9568 3186711 PK04_096102 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F01 mock treatment 8449760.0 -933000.0 -0.8 9606360.0 -132000.0 -0.11 8432680.0 -881251.428571429 -0.741026394934821 -0.9547 -0.8695 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F02 mock treatment 8939040.0 -443000.0 -0.38 9864520.0 126000.0 0.1 9086720.0 -227211.428571429 -0.191057467078625 -0.2704 -0.6154 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F03 compound treatment 9503200.0 121000.0 0.1 9396960.0 -342000.0 -0.28 9303440.0 -10491.4285714291 -0.00882202881033076 -0.1088 -0.3601 3068521 PK04_096103 CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F04 compound treatment 9535560.0 153000.0 0.13 8921120.0 -818000.0 -0.68 9501960.0 188028.571428571 0.158109399784269 -0.2242 -0.3163 3187122 PK04_096104 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F05 compound treatment 9251680.0 -131000.0 -0.11 9141520.0 -597000.0 -0.5 9291320.0 -22611.4285714291 -0.019013490197428 -0.362 -0.712 3068461 PK04_096105 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F06 compound treatment 9144480.0 -238000.0 -0.2 9283000.0 -456000.0 -0.38 9270200.0 -43731.4285714291 -0.0367728684561322 -0.3577 -0.829 3068863 PK04_096106 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5ccc(CN6CCCC6)cc5)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F07 compound treatment 9439720.0 57300.0 0.05 9405960.0 -333000.0 -0.28 8987760.0 -326171.428571429 -0.274270917480204 -0.2893 -0.7375 3187077 PK04_096107 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F08 compound treatment 1.034024E7 958000.0 0.82 9969880.0 231000.0 0.19 1.026508E7 951148.571428571 0.799801480124341 1.0484 0.9003 3187123 PK04_096108 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F09 mock treatment 9960360.0 578000.0 0.5 9579000.0 -160000.0 -0.13 9791240.0 477308.571428571 0.401359065630763 0.4424 0.6778 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F10 mock treatment 9730240.0 348000.0 0.3 9884640.0 146000.0 0.12 9457640.0 143708.571428571 0.120841613589867 0.3125 0.9064 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F11 compound treatment 9632680.0 250000.0 0.22 9842000.0 103000.0 0.09 1.009636E7 782428.571428571 0.657928265171284 0.5537 0.7937 3187438 PK04_096109 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F12 compound treatment 9550880.0 168000.0 0.14 9015520.0 -723000.0 -0.6 8968240.0 -345691.428571429 -0.290684888295067 -0.4305 -0.631 3187124 PK04_096110 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OC)c3ccc(CO)cc3)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F13 compound treatment 9385600.0 3160.0 0.0 9968880.0 230000.0 0.19 9985520.0 671588.571428571 0.564725164499183 0.4378 0.7345 3068559 PK04_096111 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4CCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F14 compound treatment 9912680.0 530000.0 0.46 9945640.0 207000.0 0.17 9569280.0 255348.571428571 0.214717417983889 0.4865 0.9133 3068864 PK04_096112 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F15 compound treatment 4722040.0 -4660000.0 -4.01 3732800.0 -6010000.0 -4.98 3254760.0 -6059171.42857143 -5.09503396469379 -8.1339 -0.9947 3186801 PK04_096113 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F16 compound treatment 9774960.0 393000.0 0.34 8444640.0 -1290000.0 -1.07 8958960.0 -354971.428571429 -0.298488251469346 -0.5971 -0.5128 3187125 PK04_096114 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F17 mock treatment 9618080.0 236000.0 0.2 1.006156E7 323000.0 0.27 9783680.0 469748.571428571 0.395002015458613 0.4998 0.9638 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F18 mock treatment 1.009976E7 717000.0 0.62 1.03998E7 661000.0 0.55 1.000276E7 688828.571428571 0.579221929706572 1.0075 0.9988 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F19 compound treatment 5426400.0 -3960000.0 -3.4 4061120.0 -5680000.0 -4.71 3669600.0 -5644331.42857143 -4.74620344969186 -7.4252 -0.9896 3186718 PK04_096115 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NC6CC6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F20 compound treatment 8656160.0 -726000.0 -0.63 8836320.0 -902000.0 -0.75 8974280.0 -339651.428571429 -0.285605975194567 -0.958 -0.9427 3068865 PK04_096116 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F21 compound treatment 9220440.0 -162000.0 -0.14 8904400.0 -834000.0 -0.69 9074080.0 -239851.428571429 -0.20168618588497 -0.5965 -0.8124 3067569 PK04_096117 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F22 compound treatment 9130320.0 -252000.0 -0.22 1.004416E7 305000.0 0.25 9328240.0 14308.5714285709 0.0120317865692082 0.028 0.0838 3187126 PK04_096118 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C=C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F23 compound treatment 9017520.0 -365000.0 -0.31 9490160.0 -249000.0 -0.21 9255840.0 -58091.4285714291 -0.0488479002646072 -0.3286 -0.8673 3068643 PK04_096119 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 F24 compound treatment 8219240.0 -1160000.0 -1.0 8732280.0 -1010000.0 -0.83 7979000.0 -1334931.42857143 -1.122516675636 -1.7081 -0.9929 3187127 PK04_096120 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)c5cccs5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G01 compound treatment 8650480.0 -732000.0 -0.63 8592000.0 -1150000.0 -0.95 8339160.0 -974771.428571429 -0.819665460027341 -1.3862 -0.9867 3186434 PK04_096121 CN(C)CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G02 compound treatment 9355640.0 -26800.0 -0.02 9435680.0 -303000.0 -0.25 9307920.0 -6011.4285714291 -0.00505488796757533 -0.1614 -0.6391 3067602 PK04_096122 CC(C)N1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G03 mock treatment 9534960.0 153000.0 0.13 9018880.0 -720000.0 -0.6 9486440.0 172508.571428571 0.145058947579009 -0.1852 -0.2948 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G04 mock treatment 9521760.0 139000.0 0.12 9571800.0 -167000.0 -0.14 9043760.0 -270171.428571429 -0.227181656945761 -0.1419 -0.4862 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G05 compound treatment 8670320.0 -712000.0 -0.61 5491600.0 -4250000.0 -3.52 4420640.0 -4893291.42857143 -4.11466919555279 -4.7636 -0.8738 3068238 PK04_096123 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G06 compound treatment 3815440.0 -5570000.0 -4.79 4153520.0 -5590000.0 -4.63 3320480.0 -5993451.42857143 -5.03977135393801 -8.351 -0.9994 3068315 PK04_096124 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G07 compound treatment 4095160.0 -5290000.0 -4.55 4461200.0 -5280000.0 -4.38 4162520.0 -5151411.42857143 -4.33171705143047 -7.6558 -0.9998 3186805 PK04_096125 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G08 compound treatment 7712240.0 -1670000.0 -1.44 6134680.0 -3600000.0 -2.99 7253960.0 -2059971.42857143 -1.73218805881265 -3.5562 -0.9502 3186712 PK04_096126 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G09 compound treatment 9785120.0 403000.0 0.35 9951720.0 213000.0 0.18 9063120.0 -250811.428571429 -0.210902226875283 0.1803 0.4075 3068360 PK04_096127 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G10 compound treatment 9999520.0 617000.0 0.53 1.045812E7 719000.0 0.6 9734600.0 420668.571428571 0.353731642118783 0.8554 0.9791 3186431 PK04_096128 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N([C@@H]3c4ccc(CO)cc24)C5CCCCC5)c6ccc(cc6)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G11 compound treatment 9357320.0 -25100.0 -0.02 8189520.0 -1550000.0 -1.29 7611320.0 -1702611.42857143 -1.43169130623071 -1.5811 -0.8217 3186642 PK04_096129 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G12 compound treatment 1.02324E7 850000.0 0.73 1.029672E7 558000.0 0.46 8680080.0 -633851.428571429 -0.532992768930872 0.3819 0.3756 3068326 PK04_096130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G13 compound treatment 1.061748E7 1240000.0 1.06 1.034512E7 606000.0 0.5 9753440.0 439508.571428571 0.369573814770014 1.1175 0.9066 3186484 PK04_096131 CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G14 compound treatment 1.009056E7 708000.0 0.61 9897480.0 159000.0 0.13 9539680.0 225748.571428571 0.189827380272826 0.5375 0.8247 3068146 PK04_096132 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G15 compound treatment 9789400.0 407000.0 0.35 9560840.0 -178000.0 -0.15 9750320.0 436388.571428571 0.366950270254523 0.3289 0.6225 3068195 PK04_096133 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C6CC6)C4=O)c7ccccc7C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G16 compound treatment 7831200.0 -1550000.0 -1.34 3724640.0 -6010000.0 -4.99 3811800.0 -5502131.42857143 -4.62663036312047 -6.3225 -0.9118 3068279 PK04_096134 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G17 compound treatment 9837560.0 455000.0 0.39 9074920.0 -664000.0 -0.55 9993720.0 679788.571428571 0.571620377648869 0.2382 0.2692 3068328 PK04_096135 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G18 compound treatment 3872280.0 -5510000.0 -4.74 4417080.0 -5320000.0 -4.41 4174040.0 -5139891.42857143 -4.32203011783482 -7.7821 -0.9992 3068311 PK04_096136 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G19 mock treatment 9539560.0 157000.0 0.14 9569320.0 -169000.0 -0.14 1.016264E7 848708.571428571 0.713661768532407 0.409 0.5528 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G20 mock treatment 9692440.0 310000.0 0.27 1.008396E7 345000.0 0.29 9298760.0 -15171.4285714291 -0.0127573455835663 0.312 0.7967 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G21 compound treatment 3687080.0 -5700000.0 -4.9 4092840.0 -5650000.0 -4.68 3722520.0 -5591411.42857143 -4.70170409848681 -8.2486 -0.9998 3068284 PK04_096137 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G22 compound treatment 9404440.0 22000.0 0.02 8699600.0 -1040000.0 -0.86 8905720.0 -408211.428571429 -0.343256684163163 -0.6849 -0.738 3186501 PK04_096138 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G23 compound treatment 8731040.0 -651000.0 -0.56 9390240.0 -348000.0 -0.29 9335480.0 21548.5714285709 0.0181197552525898 -0.4801 -0.7609 3186555 PK04_096139 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 G24 compound treatment 9145000.0 -237000.0 -0.2 8981440.0 -757000.0 -0.63 8640520.0 -673411.428571429 -0.566257967979846 -0.8076 -0.9282 3186877 PK04_096140 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H01 compound treatment 8520840.0 -862000.0 -0.74 9422960.0 -316000.0 -0.26 8506560.0 -807371.428571429 -0.678902206215453 -0.9713 -0.9349 3186629 PK04_096141 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H02 compound treatment 9339680.0 -42800.0 -0.04 9443480.0 -295000.0 -0.24 8788000.0 -525931.428571429 -0.442245036843781 -0.418 -0.8246 3068866 PK04_096142 OCc1ccc(cc1)c2cc[n+](Cc3cc4OCOc4cc3Br)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H03 mock treatment 9527120.0 145000.0 0.12 9748920.0 10200.0 0.01 8568040.0 -745891.428571429 -0.627204925185853 -0.2853 -0.4462 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H04 mock treatment 9581400.0 199000.0 0.17 1.026368E7 525000.0 0.44 9668120.0 354188.571428571 0.29782996282718 0.5222 0.9415 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H05 compound treatment 9759080.0 377000.0 0.32 9872040.0 133000.0 0.11 9564360.0 250428.571428571 0.210580290094077 0.3726 0.9267 3186432 PK04_096143 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H06 compound treatment 1.00364E7 654000.0 0.56 9975000.0 236000.0 0.2 9610000.0 296068.571428571 0.248958037429648 0.5818 0.9008 3068867 PK04_096144 OCc1ccc(cc1)c2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H07 compound treatment 9878280.0 496000.0 0.43 9960560.0 222000.0 0.18 9449120.0 135188.571428571 0.113677318951413 0.4183 0.8742 3187128 PK04_096145 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3C4CC5CC(C4)CC3C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H08 compound treatment 9634760.0 252000.0 0.22 8993000.0 -746000.0 -0.62 9760840.0 446908.571428571 0.375796324197779 -0.0148 -0.0196 3068868 PK04_096146 COc1cc2CC[N+](=Cc2cc1O)Cc3sc4ccccc4c3Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H09 compound treatment 9312800.0 -69600.0 -0.06 9418200.0 -321000.0 -0.27 9147960.0 -165971.428571429 -0.139561997165602 -0.2687 -0.8774 3186637 PK04_096147 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H10 compound treatment 7672280.0 -1710000.0 -1.47 7086640.0 -2650000.0 -2.2 6466360.0 -2847571.42857143 -2.39446487304349 -3.5024 -0.9813 3187129 PK04_096148 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C4CC4)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H11 compound treatment 9985120.0 603000.0 0.52 1.023152E7 493000.0 0.41 9307000.0 -6931.4285714291 -0.00582849724778404 0.5321 0.8057 3187130 PK04_096149 CC1(C)OB(OC1(C)C)/C=C\CC(OC(=O)c2ccncc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H12 compound treatment 1.07832E7 1400000.0 1.21 9801320.0 62600.0 0.05 9986000.0 672068.571428571 0.565128786732335 1.0523 0.7897 3187131 PK04_096150 C[n+]1ccc(cc1)c2ccc(CO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H13 compound treatment 9044360.0 -338000.0 -0.29 6461160.0 -3280000.0 -2.72 5848560.0 -3465371.42857143 -2.91396032229669 -3.4202 -0.8559 3068898 PK04_096151 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)C)c2ccccc2)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H14 compound treatment 9324680.0 -57800.0 -0.05 1.007672E7 338000.0 0.28 9824120.0 510188.571428571 0.4290071886017 0.3809 0.7397 3187132 PK04_096152 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H15 compound treatment 9485080.0 103000.0 0.09 9785240.0 46500.0 0.04 9093240.0 -220691.428571429 -0.185574931744972 -0.0339 -0.1619 3187133 PK04_096153 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H16 compound treatment 9473320.0 90900.0 0.08 9444960.0 -294000.0 -0.24 9151560.0 -162371.428571429 -0.136534830416959 -0.1744 -0.6011 3187134 PK04_096154 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C2)c6cccs6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H17 compound treatment 9289240.0 -93200.0 -0.08 9211000.0 -528000.0 -0.44 8831520.0 -482411.428571429 -0.4056499543713 -0.5333 -0.8855 3068899 PK04_096155 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)c3ccncc3)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H18 compound treatment 9567280.0 185000.0 0.16 6663840.0 -3070000.0 -2.55 8506240.0 -807691.428571429 -0.679171287704221 -1.773 -0.6704 3068900 PK04_096156 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C5CC5)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H19 mock treatment 1.011824E7 736000.0 0.63 1.028748E7 549000.0 0.46 9860880.0 546948.571428571 0.459917924623952 0.894 0.9874 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H20 mock treatment 9547280.0 165000.0 0.14 1.019936E7 461000.0 0.38 9868680.0 554748.571428571 0.466476785912678 0.5718 0.9231 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H21 compound treatment 7721200.0 -1660000.0 -1.43 3447560.0 -6290000.0 -5.22 2833320.0 -6480611.42857143 -5.44941428540157 -6.9849 -0.9095 3187204 PK04_096157 CC(C)(C)OC(=O)COc1cccc(c1)C(=O)CCN2CCOCC2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H22 compound treatment 9285080.0 -97400.0 -0.08 9617880.0 -121000.0 -0.1 9087200.0 -226731.428571429 -0.190653844845472 -0.2163 -0.936 3187205 PK04_096158 OCCCc1cc[n+](Cc2cc3OCOc3cc2Br)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H23 compound treatment 8670480.0 -712000.0 -0.61 9094200.0 -645000.0 -0.53 8080760.0 -1233171.42857143 -1.0369487622077 -1.2611 -0.957 3068901 PK04_096159 COc1ccc(/C=C/C(=O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 H24 compound treatment 8831600.0 -551000.0 -0.47 8208720.0 -1530000.0 -1.27 7421040.0 -1892891.42857143 -1.59169388648953 -1.9255 -0.9212 3187206 PK04_096160 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I01 compound treatment 3225840.0 -6160000.0 -5.3 3381520.0 -6360000.0 -5.27 2868680.0 -6445251.42857143 -5.41968078089268 -9.233 -0.9999 3186796 PK04_096161 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I02 compound treatment 8931000.0 -451000.0 -0.39 9166920.0 -572000.0 -0.47 8594760.0 -719171.428571429 -0.604736620873705 -0.8473 -0.9839 3186628 PK04_096162 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I03 compound treatment 9050440.0 -332000.0 -0.29 8818200.0 -921000.0 -0.76 8911960.0 -401971.428571429 -0.338009595132182 -0.801 -0.9075 3186882 PK04_096163 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I04 compound treatment 3519040.0 -5860000.0 -5.05 3868000.0 -5870000.0 -4.87 3644320.0 -5669611.42857143 -4.76746088730455 -8.4778 -0.9997 3186797 PK04_096164 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I05 mock treatment 8537480.0 -845000.0 -0.73 9829720.0 91000.0 0.08 8925680.0 -388251.428571429 -0.326472726301244 -0.5648 -0.7053 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I06 mock treatment 9645640.0 263000.0 0.23 1.012428E7 386000.0 0.32 9662840.0 348908.571428571 0.293390118262504 0.4848 0.9903 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I07 compound treatment 9446440.0 64000.0 0.06 9195600.0 -543000.0 -0.45 9918240.0 604308.571428571 0.50815078148566 0.065 0.0955 3186430 PK04_096165 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(C5CC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I08 compound treatment 9266920.0 -116000.0 -0.1 8581560.0 -1160000.0 -0.96 9833600.0 519668.571428571 0.436978727706459 -0.3593 -0.3392 3186557 PK04_096166 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I09 compound treatment 9488360.0 106000.0 0.09 9749000.0 10300.0 0.01 9839800.0 525868.571428571 0.442192181551344 0.3128 0.6928 3186558 PK04_096167 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I10 compound treatment 3706600.0 -5680000.0 -4.88 4032760.0 -5710000.0 -4.73 3723800.0 -5590131.42857143 -4.70062777253174 -8.2671 -0.9999 3068320 PK04_096168 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I11 compound treatment 9630880.0 248000.0 0.21 1.070468E7 966000.0 0.8 9639320.0 325388.571428571 0.273612628838038 0.7441 0.852 3068364 PK04_096169 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I12 compound treatment 9468360.0 85900.0 0.07 9788600.0 49900.0 0.04 8452680.0 -861251.428571429 -0.724208801886806 -0.3515 -0.4821 3186489 PK04_096170 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I13 compound treatment 9675800.0 293000.0 0.25 9818800.0 80100.0 0.07 9846600.0 532668.571428571 0.447910163187669 0.4427 0.8539 3186807 PK04_096171 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I14 compound treatment 4591520.0 -4790000.0 -4.12 4237200.0 -5500000.0 -4.56 4114560.0 -5199371.42857143 -4.37204563955961 -7.5397 -0.9991 3068281 PK04_096172 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I15 compound treatment 1.01112E7 729000.0 0.63 9741440.0 2700.0 0.0 9524800.0 210868.571428571 0.177315091045103 0.4658 0.7146 3186567 PK04_096173 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I16 compound treatment 9773160.0 391000.0 0.34 1.033416E7 595000.0 0.49 9337840.0 23908.5714285709 0.0201042312322556 0.4909 0.8211 3068410 PK04_096174 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I17 compound treatment 9914520.0 532000.0 0.46 9807920.0 69200.0 0.06 9805080.0 491148.571428571 0.412996840019989 0.536 0.8654 3186973 PK04_096175 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I18 compound treatment 9325480.0 -57000.0 -0.05 9965720.0 227000.0 0.19 9709680.0 395748.571428571 0.332776921180956 0.2725 0.707 3068148 PK04_096176 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I19 compound treatment 9365080.0 -17400.0 -0.01 7902680.0 -1840000.0 -1.52 8715480.0 -598451.428571429 -0.503225629235885 -1.1785 -0.7347 3068239 PK04_096177 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I20 compound treatment 4931720.0 -4450000.0 -3.83 4812080.0 -4930000.0 -4.09 7570840.0 -1743091.42857143 -1.4657301145599 -5.4174 -0.9356 3068268 PK04_096178 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I21 mock treatment 8821200.0 -561000.0 -0.48 9569000.0 -170000.0 -0.14 9520200.0 206268.571428571 0.173447044644059 -0.26 -0.4886 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I22 mock treatment 9124640.0 -258000.0 -0.22 9790200.0 51500.0 0.04 8885600.0 -428331.428571429 -0.360175182769466 -0.3114 -0.7324 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I23 compound treatment 8764040.0 -618000.0 -0.53 9701160.0 -37600.0 -0.03 8599680.0 -714251.428571429 -0.600599492983893 -0.672 -0.8368 3186564 PK04_096179 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 I24 compound treatment 8837560.0 -545000.0 -0.47 8452720.0 -1290000.0 -1.07 7691600.0 -1622331.42857143 -1.36418548773598 -1.6743 -0.9332 3068366 PK04_096180 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J01 compound treatment 2017600.0 -7360000.0 -6.34 1953800.0 -7780000.0 -6.46 1814160.0 -7499771.42857143 -6.30640519194233 -11.0291 -0.9999 1230870 PK04_096181 Oc1cccc(c1)C(=O)CCN2CCOCC2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J02 compound treatment 7397000.0 -1990000.0 -1.71 8335480.0 -1400000.0 -1.16 7406040.0 -1907891.42857143 -1.60430708127554 -2.5849 -0.9877 3187207 PK04_096182 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)C3CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J03 compound treatment 7751040.0 -1630000.0 -1.4 8758240.0 -980000.0 -0.81 6713480.0 -2600451.42857143 -2.18666669334222 -2.5427 -0.9338 3068902 PK04_096183 COc1ccc(CC[C@H](O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J04 compound treatment 9018600.0 -364000.0 -0.31 9050920.0 -688000.0 -0.57 7993400.0 -1320531.42857143 -1.11040800864143 -1.1513 -0.8945 3187208 PK04_096184 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J05 mock treatment 9583880.0 201000.0 0.17 9078760.0 -660000.0 -0.55 9639040.0 325108.571428571 0.273377182535366 -0.0582 -0.0915 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J06 mock treatment 9496840.0 114000.0 0.1 9607240.0 -131000.0 -0.11 9972920.0 658988.571428571 0.554130080878933 0.3138 0.5474 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J07 compound treatment 9053240.0 -329000.0 -0.28 1.029984E7 561000.0 0.47 8679040.0 -634891.428571429 -0.533867283769369 -0.2031 -0.2662 3187209 PK04_096185 CCCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c5cccc(O)c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J08 compound treatment 9474960.0 92500.0 0.08 7740480.0 -2000000.0 -1.66 8476040.0 -837891.428571429 -0.704565853206724 -1.3179 -0.7309 3068903 PK04_096186 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J09 compound treatment 9935200.0 553000.0 0.48 9466760.0 -272000.0 -0.23 9347320.0 33388.5714285709 0.0280757703370148 0.1606 0.3046 1032549 PK04_096187 CCOC(=O)C1CCCCN1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J10 compound treatment 9516840.0 134000.0 0.12 9972160.0 233000.0 0.19 9909600.0 595668.571428571 0.500885581288917 0.4678 0.8515 3187210 PK04_096188 COc1cc2CCN(C)C(C=C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J11 compound treatment 9684400.0 302000.0 0.26 9968480.0 230000.0 0.19 9942360.0 628428.571428571 0.528432798701566 0.5652 0.9131 3187211 PK04_096189 CCOC(=O)[C@@H]1CCCCN1C(=O)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J12 compound treatment 1.006428E7 682000.0 0.59 1.021244E7 474000.0 0.39 1.006428E7 750348.571428571 0.630952845922267 0.93 0.982 3187212 PK04_096190 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4ccc(CN5CCCC5)cc4)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J13 compound treatment 1.017076E7 788000.0 0.68 1.044296E7 704000.0 0.58 1.023024E7 916308.571428571 0.770505233034698 1.1739 0.9938 3068904 PK04_096191 [O-][N+](=O)c1cc(Br)ccc1C(=O)NCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J14 compound treatment 9535200.0 153000.0 0.13 1.02604E7 522000.0 0.43 9077320.0 -236611.428571429 -0.198961735811192 0.2109 0.4268 3068905 PK04_096192 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C=C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J15 compound treatment 9233040.0 -149000.0 -0.13 9535640.0 -203000.0 -0.17 9417840.0 103908.571428571 0.0873746034243168 -0.1211 -0.5281 3187213 PK04_096193 CC(=O)Nc1cc(Br)ccc1C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J16 compound treatment 9312920.0 -69500.0 -0.06 9243840.0 -495000.0 -0.41 9201560.0 -112371.428571429 -0.0944908477969207 -0.3261 -0.7664 3187214 PK04_096194 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5cccs5)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J17 compound treatment 9223000.0 -159000.0 -0.14 9743680.0 4940.0 0.0 9450720.0 136788.571428571 0.115022726395254 -0.0104 -0.0583 3068906 PK04_096195 CC(=O)Nc1cc(Br)ccc1C(=O)NCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J18 compound treatment 9147840.0 -235000.0 -0.2 8876120.0 -863000.0 -0.72 8871560.0 -442371.428571429 -0.371981133089173 -0.7445 -0.8955 3187215 PK04_096196 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5cccs5)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J19 compound treatment 9634080.0 252000.0 0.22 9355320.0 -383000.0 -0.32 9378280.0 64348.5714285709 0.0541094043753425 -0.0274 -0.0704 3068907 PK04_096197 Brc1ccc2c(=O)oc(nc2c1)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J20 compound treatment 7249080.0 -2130000.0 -1.84 5028240.0 -4710000.0 -3.91 6659520.0 -2654411.42857143 -2.23204055938576 -4.6048 -0.9474 3187216 PK04_096198 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4ccc(CN5CCCC5)cc4)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J21 mock treatment 8918120.0 -464000.0 -0.4 9755880.0 17100.0 0.01 9346000.0 32068.5714285709 0.0269658091958458 -0.2069 -0.5163 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J22 mock treatment 8998320.0 -384000.0 -0.33 9262480.0 -476000.0 -0.4 9259320.0 -54611.4285714291 -0.0459216390742525 -0.4455 -0.8613 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J23 compound treatment 9206080.0 -176000.0 -0.15 9125400.0 -613000.0 -0.51 8515640.0 -798291.428571429 -0.671267018971654 -0.7689 -0.8984 3068908 PK04_096199 Nc1cc(Br)ccc1C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 J24 compound treatment 8281080.0 -1100000.0 -0.95 8762200.0 -977000.0 -0.81 9978920.0 664988.571428571 0.559175358793338 -0.6921 -0.5065 3068910 PK04_096200 Oc1ccc2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K01 compound treatment 8347080.0 -1040000.0 -0.89 8093080.0 -1650000.0 -1.37 8178800.0 -1135131.42857143 -0.954508921086327 -1.8537 -0.9813 3068198 PK04_096201 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(Cc6ccccc6)C4=O)c7ccccc7C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K02 compound treatment 8194320.0 -1190000.0 -1.02 7800320.0 -1940000.0 -1.61 6924200.0 -2389731.42857143 -2.00947653298833 -2.6789 -0.9673 3186870 PK04_096202 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K03 compound treatment 8498240.0 -884000.0 -0.76 9380600.0 -358000.0 -0.3 8076680.0 -1237251.42857143 -1.04037955118949 -1.2115 -0.9159 3068155 PK04_096203 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K04 compound treatment 8696680.0 -686000.0 -0.59 9727160.0 -11600.0 -0.01 8843520.0 -470411.428571429 -0.395559398542491 -0.5747 -0.8088 3186875 PK04_096204 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K05 compound treatment 9156280.0 -226000.0 -0.19 8867200.0 -872000.0 -0.72 8369600.0 -944331.428571429 -0.794069083408261 -0.9883 -0.9055 3068359 PK04_096205 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K06 compound treatment 9809120.0 427000.0 0.37 9186480.0 -552000.0 -0.46 9116240.0 -197691.428571429 -0.166234699739754 -0.1485 -0.2433 3186626 PK04_096206 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(F)(F)F)C4=O)c6ccccc6C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K07 mock treatment 9661440.0 279000.0 0.24 9755120.0 16400.0 0.01 9088240.0 -225691.428571429 -0.189779330006975 0.0369 0.1205 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K08 mock treatment 9622680.0 240000.0 0.21 9467240.0 -271000.0 -0.23 8996240.0 -317691.428571429 -0.267140258027846 -0.1649 -0.4061 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K09 compound treatment 8235600.0 -1150000.0 -0.99 8529080.0 -1210000.0 -1.0 7750520.0 -1563411.42857143 -1.31464085861653 -1.9082 -0.9908 3186869 PK04_096207 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K10 compound treatment 8829680.0 -553000.0 -0.48 1.050572E7 767000.0 0.64 9290960.0 -22971.4285714291 -0.0193162068722923 0.0815 0.1026 3068235 PK04_096208 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K11 compound treatment 9484760.0 102000.0 0.09 9976200.0 237000.0 0.2 9114800.0 -199131.428571429 -0.167445566439211 0.0679 0.2486 3186487 PK04_096209 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(Cc7ccccc7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K12 compound treatment 9721040.0 339000.0 0.29 9997800.0 259000.0 0.21 9488880.0 174948.571428571 0.147110693930867 0.3773 0.9653 3068411 PK04_096210 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K13 compound treatment 9347840.0 -34600.0 -0.03 9880720.0 142000.0 0.12 1.039548E7 1081548.57142857 0.909452186797401 0.5759 0.6276 3068329 PK04_096211 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K14 compound treatment 9900720.0 518000.0 0.45 1.046992E7 731000.0 0.61 1.005172E7 737788.571428571 0.620391397488114 0.9659 0.9901 3067608 PK04_096212 COCCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K15 mock treatment 9184920.0 -198000.0 -0.17 1.041496E7 676000.0 0.56 9299400.0 -14531.4285714291 -0.0122191826060299 0.2187 0.373 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K16 mock treatment 9541080.0 159000.0 0.14 1.0224E7 485000.0 0.4 9119600.0 -194331.428571429 -0.163409344107687 0.2169 0.4763 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K17 compound treatment 9264000.0 -118000.0 -0.1 9803480.0 64700.0 0.05 9239440.0 -74491.4285714291 -0.0626383265639797 -0.064 -0.4881 3186979 PK04_096213 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K18 compound treatment 1.017976E7 797000.0 0.69 9822720.0 84000.0 0.07 9411360.0 97428.5714285709 0.0819257032767598 0.4837 0.6964 3186636 PK04_096214 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K19 compound treatment 3728800.0 -5650000.0 -4.87 3953360.0 -5790000.0 -4.8 3715760.0 -5598171.42857143 -4.70738844493704 -8.298 -0.9999 3186793 PK04_096215 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K20 compound treatment 9310840.0 -71600.0 -0.06 9419400.0 -319000.0 -0.26 8455120.0 -858811.428571429 -0.722157055534948 -0.6055 -0.7846 3186637 PK04_096216 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K21 compound treatment 8469680.0 -913000.0 -0.79 9469000.0 -270000.0 -0.22 9309120.0 -4811.4285714291 -0.00404583238469441 -0.5851 -0.7163 3067613 PK04_096217 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N(CC4(CC5CC6CC(C5)C4)C6)[C@@H]3c7ccc(CO)cc27)c8ccc(cc8)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K22 compound treatment 9206920.0 -176000.0 -0.15 9205880.0 -533000.0 -0.44 8834440.0 -479491.428571429 -0.40319458578629 -0.5752 -0.9322 3186873 PK04_096218 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K23 mock treatment 9392000.0 9560.0 0.01 9415120.0 -324000.0 -0.27 9099040.0 -214891.428571429 -0.180697829761047 -0.2546 -0.7864 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 K24 mock treatment 9090200.0 -292000.0 -0.25 8878600.0 -860000.0 -0.71 8292480.0 -1021451.42857143 -0.858917722201408 -1.0531 -0.92 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L01 compound treatment 8343200.0 -1040000.0 -0.89 9080480.0 -658000.0 -0.55 8442840.0 -871091.428571429 -0.732483057666429 -1.2546 -0.9812 3068940 PK04_096219 Cc1nc2cc(Br)ccc2c(=O)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L02 compound treatment 4242560.0 -5140000.0 -4.42 5282240.0 -4460000.0 -3.7 4909000.0 -4404931.42857143 -3.70401720850635 -6.8269 -0.9963 3187217 PK04_096220 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5ccc(CN6CCCC6)cc5)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L03 compound treatment 9185800.0 -197000.0 -0.17 1.036588E7 627000.0 0.52 9383040.0 69108.5714285709 0.0581119915207701 0.2362 0.4294 3068941 PK04_096221 CC(C)c1nc2cc(Br)ccc2c(=O)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L04 compound treatment 8615440.0 -767000.0 -0.66 9751320.0 12600.0 0.01 8638440.0 -675491.428571429 -0.56800699765684 -0.703 -0.8072 3068942 PK04_096222 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L05 compound treatment 9362880.0 -19600.0 -0.02 1.036808E7 629000.0 0.52 9643000.0 329068.571428571 0.276707065958873 0.4515 0.7637 3187218 PK04_096223 Cc1nc2cc(Br)ccc2c(=O)n1Cc3cccc(O)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L06 compound treatment 9922400.0 540000.0 0.46 1.020992E7 471000.0 0.39 9523320.0 209388.571428571 0.176070589159549 0.5956 0.9421 3068943 PK04_096224 COc1cc2CCN(C)C(c3cccs3)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L07 mock treatment 9532280.0 150000.0 0.13 9641760.0 -97000.0 -0.08 9906680.0 592748.571428571 0.498430212703907 0.3158 0.606 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L08 mock treatment 9135600.0 -247000.0 -0.21 1.033536E7 597000.0 0.49 9635120.0 321188.571428571 0.270080934297955 0.319 0.5295 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L09 compound treatment 9307560.0 -74900.0 -0.06 8254040.0 -1480000.0 -1.23 9671840.0 357908.571428571 0.300958035134111 -0.5745 -0.4526 3187219 PK04_096225 Oc1cccc(CNC(=O)c2ccc(Br)cc2NC(=O)c3ccccc3)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L10 compound treatment 9785240.0 403000.0 0.35 7682400.0 -2060000.0 -1.71 9039160.0 -274771.428571429 -0.231049703346805 -0.9181 -0.5229 3187220 PK04_096226 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L11 compound treatment 9289800.0 -92600.0 -0.08 9518240.0 -220000.0 -0.18 9300280.0 -13651.4285714291 -0.0114792085119172 -0.1583 -0.7919 3068944 PK04_096227 Oc1cccc(Cn2c(nc3cc(Br)ccc3c2=O)c4ccccc4)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L12 compound treatment 9519840.0 137000.0 0.12 1.01798E7 441000.0 0.37 9765560.0 451628.571428571 0.379765276157111 0.4988 0.9229 3187221 PK04_096228 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L13 compound treatment 9284160.0 -98300.0 -0.08 9431320.0 -307000.0 -0.26 9125360.0 -188571.428571429 -0.158565877309859 -0.2876 -0.9219 1980253 PK04_096229 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2)/C#N)c(=O)n(c3ccccc3)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L14 compound treatment 8087120.0 -1300000.0 -1.11 8112280.0 -1630000.0 -1.35 8192880.0 -1121051.42857143 -0.942669335580525 -1.9669 -0.9894 3068945 PK04_096230 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L15 mock treatment 9500520.0 118000.0 0.1 9464080.0 -275000.0 -0.23 9298800.0 -15131.4285714291 -0.0127237103974703 -0.0802 -0.3211 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L16 mock treatment 9659320.0 277000.0 0.24 9474920.0 -264000.0 -0.22 9824520.0 510588.571428571 0.42934354046266 0.2591 0.482 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L17 compound treatment 8232520.0 -1150000.0 -0.99 5853720.0 -3890000.0 -3.22 5649600.0 -3664331.42857143 -3.08126173793834 -4.2111 -0.922 3187222 PK04_096231 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L18 compound treatment 8987040.0 -395000.0 -0.34 9487840.0 -251000.0 -0.21 9352360.0 38428.5714285709 0.0323138037851147 -0.298 -0.7446 3187223 PK04_096232 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6cccs6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L19 compound treatment 8822040.0 -560000.0 -0.48 7210880.0 -2530000.0 -2.1 7829600.0 -1484331.42857143 -1.24814409570467 -2.2098 -0.8883 3068946 PK04_096233 Cc1c(NC(=O)/C(=C/C=C/c2ccc(cc2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L20 compound treatment 8744280.0 -638000.0 -0.55 9078520.0 -660000.0 -0.55 8442440.0 -871491.428571429 -0.73281940952739 -1.0564 -0.99 3187224 PK04_096234 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5cccs5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L21 compound treatment 8353360.0 -1030000.0 -0.89 8575680.0 -1160000.0 -0.96 9090040.0 -223891.428571429 -0.188265746632654 -1.1771 -0.8896 3068947 PK04_096235 CN(C)c1ccc(/C=C/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L22 compound treatment 8645760.0 -737000.0 -0.63 9549160.0 -190000.0 -0.16 9131760.0 -182171.428571429 -0.153184247534494 -0.5453 -0.8127 3187225 PK04_096236 COc1cc2CCN(C)C(C3CC3)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L23 mock treatment 9024000.0 -358000.0 -0.31 9540880.0 -198000.0 -0.16 8787680.0 -526251.428571429 -0.442514118332549 -0.5284 -0.9371 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 L24 mock treatment 8722600.0 -660000.0 -0.57 8472000.0 -1270000.0 -1.05 8139520.0 -1174411.42857143 -0.987538673832629 -1.5047 -0.9709 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M01 compound treatment 7990320.0 -1390000.0 -1.2 7914280.0 -1820000.0 -1.51 7236280.0 -2077651.42857143 -1.7470548110671 -2.5742 -0.9887 3186502 PK04_096237 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M02 compound treatment 5063080.0 -4320000.0 -3.72 5160200.0 -4580000.0 -3.8 5302320.0 -4011611.42857143 -3.37328242362408 -6.2867 -0.9987 3186497 PK04_096238 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC(C)C)c5ccccc5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M03 compound treatment 8773840.0 -609000.0 -0.52 8451680.0 -1290000.0 -1.07 8053160.0 -1260771.42857143 -1.06015704061396 -1.5309 -0.9609 3068404 PK04_096239 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M04 compound treatment 2731240.0 -6650000.0 -5.72 7826640.0 -1910000.0 -1.59 2739640.0 -6574291.42857143 -5.52818789123847 -7.4124 -0.9135 3186643 PK04_096240 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M05 compound treatment 4028920.0 -5350000.0 -4.61 3590440.0 -6150000.0 -5.1 3346960.0 -5966971.42857143 -5.01750486074244 -8.5017 -0.999 3186723 PK04_096241 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M06 compound treatment 9715800.0 333000.0 0.29 9005120.0 -734000.0 -0.61 9012520.0 -301411.428571429 -0.253450737286761 -0.3321 -0.4618 3186868 PK04_096242 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M07 compound treatment 3984480.0 -5400000.0 -4.65 3955600.0 -5780000.0 -4.8 3362840.0 -5951091.42857143 -5.00415169186232 -8.3412 -0.9995 3186798 PK04_096243 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M08 compound treatment 3372960.0 -6010000.0 -5.17 3253680.0 -6490000.0 -5.38 3253280.0 -6060651.42857143 -5.09627846657934 -9.0344 -0.9997 3186799 PK04_096244 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M09 mock treatment 9405120.0 22700.0 0.02 9062520.0 -676000.0 -0.56 8683720.0 -630211.428571429 -0.529931966996133 -0.6186 -0.8013 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M10 mock treatment 9370240.0 -12200.0 -0.01 1.003088E7 292000.0 0.24 9038400.0 -275531.428571429 -0.23168877188263 1.0E-4 3.0E-4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M11 compound treatment 8363360.0 -1020000.0 -0.88 7910920.0 -1830000.0 -1.52 7659640.0 -1654291.42857143 -1.39106000142671 -2.1849 -0.9768 3186496 PK04_096245 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M12 compound treatment 9443040.0 60600.0 0.05 9952280.0 214000.0 0.18 9251560.0 -62371.4285714291 -0.0524468651768825 0.1021 0.5319 3068379 PK04_096246 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M13 mock treatment 9872000.0 490000.0 0.42 1.05196E7 781000.0 0.65 9487080.0 173148.571428571 0.145597110556546 0.7013 0.8919 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M14 mock treatment 9690160.0 308000.0 0.26 9839520.0 101000.0 0.08 9416720.0 102788.571428571 0.0864328182136279 0.2511 0.8632 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M15 compound treatment 8909680.0 -473000.0 -0.41 9570640.0 -168000.0 -0.14 9341560.0 27628.5714285709 0.0232323035391864 -0.302 -0.7011 3186488 PK04_096247 CC(C)N1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M16 compound treatment 9328640.0 -53800.0 -0.05 9310880.0 -428000.0 -0.35 9471880.0 157948.571428571 0.132815739840054 -0.155 -0.4059 3186886 PK04_096248 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M17 compound treatment 9262840.0 -120000.0 -0.1 9529640.0 -209000.0 -0.17 9581280.0 267348.571428571 0.224807973812698 -0.0298 -0.0986 3068154 PK04_096249 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M18 compound treatment 9470160.0 87700.0 0.08 9149200.0 -590000.0 -0.49 9678920.0 364988.571428571 0.306911463073109 -0.0616 -0.1057 3068369 PK04_096250 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M19 compound treatment 3479800.0 -5900000.0 -5.08 3605720.0 -6130000.0 -5.09 3810920.0 -5503011.42857143 -4.62737033721458 -8.542 -0.999 3186727 PK04_096251 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M20 compound treatment 8698760.0 -684000.0 -0.59 9409360.0 -329000.0 -0.27 9253840.0 -60091.4285714291 -0.0505296595694087 -0.5266 -0.8093 3186984 PK04_096252 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M21 compound treatment 8385320.0 -997000.0 -0.86 8917680.0 -821000.0 -0.68 8893760.0 -420171.428571429 -0.353313604805876 -1.0927 -0.9492 3068372 PK04_096253 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M22 compound treatment 3823840.0 -5560000.0 -4.78 4009960.0 -5730000.0 -4.75 3490480.0 -5823451.42857143 -4.89682181302988 -8.333 -0.9999 3186721 PK04_096254 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M23 compound treatment 3634320.0 -5750000.0 -4.95 3791920.0 -5950000.0 -4.93 3618400.0 -5695531.42857143 -4.78925648789478 -8.4695 -0.9999 3068316 PK04_096255 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 M24 compound treatment 3565560.0 -5820000.0 -5.01 3790760.0 -5950000.0 -4.93 3216560.0 -6097371.42857143 -5.1271555674155 -8.6993 -0.9999 3068283 PK04_096256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N01 compound treatment 8137680.0 -1240000.0 -1.07 8841160.0 -898000.0 -0.74 8358040.0 -955891.428571429 -0.803789652190014 -1.5125 -0.987 1694663 PK04_096257 Cc1c(NC(=O)CC#N)c(=O)n(c2ccccc2)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N02 compound treatment 7871720.0 -1510000.0 -1.3 8327800.0 -1410000.0 -1.17 7911320.0 -1402611.42857143 -1.17942741051048 -2.1074 -0.9988 3187226 PK04_096258 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C)C=C(CCCO)C=C1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N03 compound treatment 9603200.0 221000.0 0.19 8761720.0 -977000.0 -0.81 9129680.0 -184251.428571429 -0.154933277211488 -0.4477 -0.5287 3068949 PK04_096259 Cc1ccccc1/C=C/C=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N04 compound treatment 8833360.0 -549000.0 -0.47 9370600.0 -368000.0 -0.31 8718720.0 -595211.428571429 -0.500501179162106 -0.7381 -0.9802 3187227 PK04_096260 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2ccc(CN3CCCC3)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N05 compound treatment 9165440.0 -217000.0 -0.19 9017560.0 -721000.0 -0.6 8356320.0 -957611.428571429 -0.805235965192143 -0.9181 -0.8998 3068950 PK04_096261 CCOc1ccc(cc1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N06 compound treatment 8875480.0 -507000.0 -0.44 9672200.0 -66500.0 -0.06 9584440.0 270508.571428571 0.227465153514284 -0.1524 -0.3079 3187228 PK04_096262 Oc1ccc2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N07 compound treatment 8936200.0 -446000.0 -0.38 9600800.0 -138000.0 -0.11 9000000.0 -313931.428571429 -0.263978550534819 -0.4402 -0.9173 3068951 PK04_096263 [O-][N+](=O)c1cccc(c1)C2SCC(=O)N2c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N08 compound treatment 9074120.0 -308000.0 -0.27 9605360.0 -133000.0 -0.11 9144000.0 -169931.428571429 -0.142891880589109 -0.2996 -0.9331 3187299 PK04_096264 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4cccs4)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N09 mock treatment 9272880.0 -110000.0 -0.09 9718160.0 -20600.0 -0.02 9085080.0 -228851.428571429 -0.192436509708562 -0.1754 -0.8159 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N10 mock treatment 9378360.0 -4080.0 0.0 9940200.0 201000.0 0.17 9481640.0 167708.571428571 0.141022725247486 0.1759 0.8042 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N11 compound treatment 8849120.0 -533000.0 -0.46 9430560.0 -308000.0 -0.26 8366040.0 -947891.428571429 -0.797062614970808 -0.8728 -0.9143 3068985 PK04_096265 Cc1cc(C)cc(c1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N12 compound treatment 9204960.0 -177000.0 -0.15 9658360.0 -80400.0 -0.07 9165120.0 -148811.428571429 -0.125132502330405 -0.1989 -0.9545 3187300 PK04_096266 COc1cc2CCN(C)C(c3ccc(CN4CCCC4)cc3)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N13 mock treatment 9332480.0 -50000.0 -0.04 1.02608E7 522000.0 0.43 9766360.0 452428.571428571 0.380437979879031 0.4449 0.7696 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N14 mock treatment 8813240.0 -569000.0 -0.49 9939000.0 200000.0 0.17 9163400.0 -150531.428571429 -0.126578815332534 -0.26 -0.4882 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N15 compound treatment 8788880.0 -594000.0 -0.51 9571720.0 -167000.0 -0.14 9141760.0 -172171.428571429 -0.144775451010486 -0.4585 -0.8356 3068986 PK04_096267 COc1ccc(/C=C/C=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N16 compound treatment 8622920.0 -760000.0 -0.65 8839080.0 -900000.0 -0.75 8915520.0 -398411.428571429 -0.335016063569636 -1.0017 -0.9566 3187301 PK04_096268 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N17 compound treatment 8912280.0 -470000.0 -0.4 9074200.0 -665000.0 -0.55 8951520.0 -362411.428571429 -0.304744396083208 -0.7278 -0.9722 3068987 PK04_096269 Cc1cccc(/C=C/C=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N18 compound treatment 8556760.0 -826000.0 -0.71 9436320.0 -302000.0 -0.25 8779800.0 -534131.428571429 -0.449140249993467 -0.8144 -0.9283 3068988 PK04_096270 OCCCc1cc[n+](Cc2sc3ccccc3c2Cl)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N19 compound treatment 8566760.0 -816000.0 -0.7 9236360.0 -502000.0 -0.42 1.099572E7 1681788.57142857 1.41418178935444 0.1706 0.1045 3068989 PK04_096271 Cc1ccc(/C=C/C=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N20 compound treatment 6986520.0 -2400000.0 -2.06 7937680.0 -1800000.0 -1.49 7157440.0 -2156491.42857143 -1.81334976286237 -3.1001 -0.9917 3187302 PK04_096272 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N21 compound treatment 8542840.0 -840000.0 -0.72 9222080.0 -517000.0 -0.43 9121440.0 -192491.428571429 -0.16186212554727 -0.7581 -0.886 3068990 PK04_096273 COc1cccc(/C=C/C=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N22 compound treatment 8886480.0 -496000.0 -0.43 8250200.0 -1490000.0 -1.23 8252760.0 -1061171.42857143 -0.892317461994767 -1.4746 -0.932 3068991 PK04_096274 Oc1ccc2cc[n+](Cc3cc4OCOc4cc3Br)cc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N23 compound treatment 8898880.0 -484000.0 -0.42 8540760.0 -1200000.0 -0.99 8352000.0 -961931.428571429 -0.808868565290515 -1.281 -0.9509 3187303 PK04_096275 Clc1ccccc1/C=C/C=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 N24 compound treatment 1.118448E7 1800000.0 1.55 8195320.0 -1540000.0 -1.28 7537200.0 -1776731.42857143 -1.49401730606666 -0.7064 -0.2819 3187304 PK04_096276 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)C5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O01 compound treatment 7425720.0 -1960000.0 -1.68 7853480.0 -1890000.0 -1.56 7722360.0 -1591571.42857143 -1.33832002962813 -2.6479 -0.9956 3186631 PK04_096277 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O02 compound treatment 8766240.0 -616000.0 -0.53 8636920.0 -1100000.0 -0.91 8201000.0 -1112931.42857143 -0.93584139280303 -1.3742 -0.9735 3067615 PK04_096278 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O03 compound treatment 3281440.0 -6100000.0 -5.25 3600760.0 -6140000.0 -5.09 3364680.0 -5949251.42857143 -5.0026044733019 -8.8596 -0.9998 3186715 PK04_096279 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O04 compound treatment 8409520.0 -973000.0 -0.84 8649840.0 -1090000.0 -0.9 8763520.0 -550411.428571429 -0.462829770734552 -1.2722 -0.9669 3068363 PK04_096280 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O05 compound treatment 3657640.0 -5720000.0 -4.93 3469600.0 -6270000.0 -5.2 3531200.0 -5782731.42857143 -4.86258119358412 -8.6546 -0.9996 3068310 PK04_096281 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O06 compound treatment 9233720.0 -149000.0 -0.13 8779080.0 -960000.0 -0.8 9479080.0 165148.571428571 0.13887007333734 -0.4533 -0.5541 3068196 PK04_096282 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCN6CCOCC6)C4=O)c7ccccc7C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O07 compound treatment 2852080.0 -6530000.0 -5.62 3063640.0 -6680000.0 -5.54 2964240.0 -6349691.42857143 -5.33932632130926 -9.5246 -0.9998 3068277 PK04_096283 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O08 compound treatment 3311200.0 -6070000.0 -5.23 3353280.0 -6390000.0 -5.3 3279640.0 -6034291.42857143 -5.07411287894206 -9.0046 -0.9998 3186720 PK04_096284 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O09 compound treatment 9481960.0 99500.0 0.09 8977120.0 -762000.0 -0.63 9400760.0 86828.5714285709 0.0730123789613117 -0.2732 -0.4257 3186632 PK04_096285 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O10 compound treatment 9037520.0 -345000.0 -0.3 1.009384E7 355000.0 0.29 9523080.0 209148.571428571 0.175868778042973 0.1002 0.2209 3068157 PK04_096286 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(C5CCCCC5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O11 mock treatment 9797720.0 415000.0 0.36 1.082232E7 1080000.0 0.9 9857240.0 543308.571428571 0.456857122689213 0.9891 0.9246 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O12 mock treatment 9677040.0 295000.0 0.25 1.019576E7 457000.0 0.38 9154000.0 -159931.428571429 -0.134483084065101 0.2876 0.6049 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O13 compound treatment 8341440.0 -1040000.0 -0.9 9794720.0 56000.0 0.05 8707000.0 -606931.428571429 -0.510356288688243 -0.7851 -0.7607 3186874 PK04_096287 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O14 compound treatment 9632840.0 250000.0 0.22 1.00272E7 288000.0 0.24 9442640.0 128708.571428571 0.108228418803856 0.3251 0.9568 3068138 PK04_096288 COCCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O15 compound treatment 8913960.0 -468000.0 -0.4 9017600.0 -721000.0 -0.6 9553840.0 239908.571428571 0.201734236150821 -0.4617 -0.6163 3186972 PK04_096289 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O16 compound treatment 9766360.0 384000.0 0.33 9761520.0 22800.0 0.02 9291440.0 -22491.4285714291 -0.0189125846391399 0.1908 0.5754 3186981 PK04_096290 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O17 compound treatment 3230640.0 -6150000.0 -5.29 2926640.0 -6810000.0 -5.65 2886600.0 -6427331.42857143 -5.40461221752166 -9.4398 -0.9996 3186709 PK04_096291 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCc5ccccc5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O18 compound treatment 3642440.0 -5740000.0 -4.94 3786360.0 -5950000.0 -4.94 3550760.0 -5763171.42857143 -4.84613358758316 -8.501 -1.0 3186725 PK04_096292 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O19 compound treatment 3541240.0 -5840000.0 -5.03 3571840.0 -6170000.0 -5.12 3598880.0 -5715051.42857143 -4.80567045870964 -8.6306 -0.9997 3068321 PK04_096293 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O20 compound treatment 8707000.0 -675000.0 -0.58 9242160.0 -497000.0 -0.41 8855400.0 -458531.428571429 -0.38556974827197 -0.7961 -0.9827 3068192 PK04_096294 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O21 compound treatment 8944600.0 -438000.0 -0.38 9222160.0 -517000.0 -0.43 8781240.0 -532691.428571429 -0.44792938329401 -0.7236 -0.9974 3068201 PK04_096295 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O22 compound treatment 9008280.0 -374000.0 -0.32 8438920.0 -1300000.0 -1.08 8266760.0 -1047171.42857143 -0.880545146861156 -1.3168 -0.9216 3068381 PK04_096296 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O23 compound treatment 8654000.0 -728000.0 -0.63 8521960.0 -1220000.0 -1.01 8439880.0 -874051.428571429 -0.734972061437536 -1.3691 -0.9799 3186880 PK04_096297 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCc6ccccc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 O24 compound treatment 8056840.0 -1330000.0 -1.14 8398800.0 -1340000.0 -1.11 7681320.0 -1632611.42857143 -1.37282973056266 -2.093 -0.9954 3186977 PK04_096298 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P01 compound treatment 7763640.0 -1620000.0 -1.39 7581240.0 -2160000.0 -1.79 7851920.0 -1462011.42857143 -1.22937566186309 -2.5475 -0.9874 3068992 PK04_096299 Cc1c(NC(=O)/C(=C/c2cccc(c2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P02 compound treatment 8037720.0 -1340000.0 -1.16 9120480.0 -618000.0 -0.51 8357400.0 -956531.428571429 -0.804327815167551 -1.4287 -0.9526 3187305 PK04_096300 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)C2CC2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P03 compound treatment 7813040.0 -1570000.0 -1.35 8905680.0 -833000.0 -0.69 8945040.0 -368891.428571429 -0.310193296230765 -1.3579 -0.8769 3187306 PK04_096301 COc1cccc(/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P04 compound treatment 8112920.0 -1270000.0 -1.09 8472760.0 -1270000.0 -1.05 8261960.0 -1051971.42857143 -0.88458136919268 -1.7479 -0.9961 3068993 PK04_096302 COc1cc2CC[N+](=Cc2cc1O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P05 compound treatment 1.12206E7 1840000.0 1.58 7780160.0 -1960000.0 -1.62 7949480.0 -1364451.42857143 -1.14733944297487 -0.6871 -0.2704 3068994 PK04_096303 Cc1c(NC(=O)/C(=C/c2ccccc2Cl)/C#N)c(=O)n(c3ccccc3)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P06 compound treatment 5433560.0 -3950000.0 -3.4 5599640.0 -4140000.0 -3.43 5363280.0 -3950651.42857143 -3.32202240001373 -5.8626 -0.9999 3187307 PK04_096304 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4cccs4)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P07 compound treatment 8514040.0 -868000.0 -0.75 8890800.0 -848000.0 -0.7 8044840.0 -1269091.42857143 -1.06715315932193 -1.4537 -0.9819 3187308 PK04_096305 Cc1c(NC(=O)/C(=C/c2ccc(Cl)cc2)/C#N)c(=O)n(c3ccccc3)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P08 compound treatment 8616040.0 -766000.0 -0.66 8546720.0 -1190000.0 -0.99 8680160.0 -633771.428571429 -0.53292549855868 -1.2594 -0.9668 3068995 PK04_096306 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3CCCO)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P09 compound treatment 8521800.0 -861000.0 -0.74 8486480.0 -1250000.0 -1.04 8101640.0 -1212291.42857143 -1.01939119506557 -1.616 -0.9895 1972122 PK04_096307 Cc1cc(C)cc(c1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)CC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P10 compound treatment 8544240.0 -838000.0 -0.72 8936400.0 -802000.0 -0.67 8768120.0 -545811.428571429 -0.458961724333508 -1.0658 -0.9836 3187309 PK04_096308 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P11 mock treatment 9204280.0 -178000.0 -0.15 8597120.0 -1140000.0 -0.95 8605920.0 -708011.428571429 -0.595352403952912 -0.979 -0.8671 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P12 mock treatment 8743600.0 -639000.0 -0.55 8191520.0 -1550000.0 -1.28 8631640.0 -682291.428571429 -0.573724979293165 -1.3897 -0.9206 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P13 compound treatment 8189760.0 -1190000.0 -1.03 8433600.0 -1310000.0 -1.08 8186160.0 -1127771.42857143 -0.948320046844658 -1.7652 -0.9985 3068996 PK04_096309 Clc1ccc(/C=C/C=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P14 compound treatment 8519880.0 -863000.0 -0.74 8131760.0 -1610000.0 -1.33 7734960.0 -1578971.42857143 -1.32772494600788 -1.9648 -0.9714 3187310 PK04_096310 COc1cc2CC[N+](=Cc2cc1O)Cc3cccc(OC(F)(F)F)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P15 compound treatment 8251040.0 -1130000.0 -0.97 9009600.0 -729000.0 -0.6 8336280.0 -977651.428571429 -0.822087193426255 -1.386 -0.9826 3068997 PK04_096311 O=C/C=C/c1ccc2OCOc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P16 compound treatment 7774960.0 -1610000.0 -1.38 7351720.0 -2390000.0 -1.98 7892360.0 -1421571.42857143 -1.19537048872 -2.6322 -0.9766 3187311 PK04_096312 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3ccc(CN4CCCC4)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P17 compound treatment 3109920.0 -6270000.0 -5.4 3425920.0 -6310000.0 -5.24 4270400.0 -5043531.42857143 -4.24100295452948 -8.5888 -0.9947 3068998 PK04_096313 O=C/C=C/c1ccc(cc1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P18 compound treatment 6900480.0 -2480000.0 -2.14 7296800.0 -2440000.0 -2.03 7024640.0 -2289291.42857143 -1.92501858070119 -3.5142 -0.9991 3187312 PK04_096314 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P19 compound treatment 3931680.0 -5450000.0 -4.69 4557720.0 -5180000.0 -4.3 4252320.0 -5061611.42857143 -4.25620605864488 -7.6472 -0.999 3187313 PK04_096315 O=C/C=C/c1ccc(\C=C\c2ccccc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P20 compound treatment 7787040.0 -1600000.0 -1.37 7702840.0 -2040000.0 -1.69 7855680.0 -1458251.42857143 -1.22621395437006 -2.4758 -0.991 3187314 PK04_096316 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4cccs4)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P21 compound treatment 8490200.0 -892000.0 -0.77 8172080.0 -1570000.0 -1.3 7904680.0 -1409251.42857143 -1.18501085140243 -1.8779 -0.9785 3069028 PK04_096317 [O-][N+](=O)c1cccc(c1)C2N(C(=O)CS2(=O)=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P22 compound treatment 7850560.0 -1530000.0 -1.32 7797560.0 -1940000.0 -1.61 7543400.0 -1770531.42857143 -1.48880385222177 -2.5505 -0.9967 3187315 PK04_096318 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P23 compound treatment 4320000.0 -5060000.0 -4.36 4113640.0 -5630000.0 -4.67 4587360.0 -4726571.42857143 -3.97447773990453 -7.5043 -0.9979 3069029 PK04_096319 CCOc1ccc(cc1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2096 P24 compound treatment 7273920.0 -2110000.0 -1.81 7181800.0 -2560000.0 -2.12 6433240.0 -2880691.42857143 -2.42231480713101 -3.6709 -0.9932 3187316 PK04_096320 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)C3CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A01 compound treatment 6054960.0 -3070000.0 -2.64 6268280.0 -1800000.0 -1.5 6675680.0 -2944035.0 -2.47557912745569 -3.8178 -0.9748 2141518 PK04_097001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A02 compound treatment 6688200.0 -2430000.0 -2.1 6537600.0 -1530000.0 -1.27 7360080.0 -2259635.0 -1.9000810933526 -3.0419 -0.9806 2141905 PK04_097002 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A03 compound treatment 6641320.0 -2480000.0 -2.14 6175280.0 -1900000.0 -1.57 7816440.0 -1803275.0 -1.51633725518299 -3.0171 -0.9874 2141091 PK04_097003 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A04 compound treatment 7196200.0 -1930000.0 -1.66 6830840.0 -1240000.0 -1.03 7947040.0 -1672675.0 -1.40651837257945 -2.364 -0.9826 2141692 PK04_097004 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A05 compound treatment 7691680.0 -1430000.0 -1.23 6335000.0 -1740000.0 -1.44 7421360.0 -2198355.0 -1.84855198825348 -2.6105 -0.9859 2141533 PK04_097005 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A06 compound treatment 7298600.0 -1820000.0 -1.57 6363120.0 -1710000.0 -1.42 7639800.0 -1979915.0 -1.66487023698306 -2.6863 -0.9979 2141714 PK04_097006 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A07 compound treatment 8082200.0 -1040000.0 -0.9 7044240.0 -1030000.0 -0.85 8502000.0 -1117715.0 -0.939863800683121 -1.5522 -0.9992 2141463 PK04_097007 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A08 compound treatment 7131600.0 -1990000.0 -1.71 7058520.0 -1010000.0 -0.84 7568720.0 -2050995.0 -1.72463996267571 -2.4708 -0.9604 2141076 PK04_097008 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A09 compound treatment 7391960.0 -1730000.0 -1.49 7116360.0 -956000.0 -0.79 8074120.0 -1545595.0 -1.29965938635236 -2.0683 -0.971 2141109 PK04_097009 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A10 compound treatment 7079880.0 -2040000.0 -1.76 6333960.0 -1740000.0 -1.44 7814360.0 -1805355.0 -1.51808628485998 -2.7242 -0.9964 2141546 PK04_097010 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A11 compound treatment 7975080.0 -1150000.0 -0.99 6979760.0 -1090000.0 -0.91 8651720.0 -967995.0 -0.813967299125679 -1.5636 -0.9969 2141079 PK04_097011 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A12 compound treatment 7003720.0 -2120000.0 -1.82 6713000.0 -1360000.0 -1.13 8744360.0 -875355.0 -0.736068208127272 -2.129 -0.9391 2141141 PK04_097012 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A13 mock treatment 7026680.0 -2100000.0 -1.8 6937720.0 -1130000.0 -0.94 8495160.0 -1124555.0 -0.945615417505542 -2.131 -0.9497 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A14 mock treatment 7847120.0 -1280000.0 -1.1 7286200.0 -786000.0 -0.65 8481640.0 -1138075.0 -0.956984110406001 -1.563 -0.9794 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A15 compound treatment 5756320.0 -3370000.0 -2.9 4921080.0 -3150000.0 -2.61 6973240.0 -2646475.0 -2.22536697808731 -4.467 -0.9943 2141882 PK04_097013 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A16 compound treatment 7591280.0 -1530000.0 -1.32 6737080.0 -1340000.0 -1.11 8432800.0 -1186915.0 -0.998052672629254 -1.9768 -0.9933 2141936 PK04_097014 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A17 compound treatment 6320800.0 -2800000.0 -2.41 5559560.0 -2510000.0 -2.08 6579480.0 -3040235.0 -2.55647175001664 -4.0718 -0.9965 2141372 PK04_097015 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A18 compound treatment 6998080.0 -2120000.0 -1.83 7450800.0 -622000.0 -0.52 8315040.0 -1304675.0 -1.09707466049597 -1.9869 -0.9056 2141092 PK04_097016 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A19 compound treatment 7486520.0 -1640000.0 -1.41 6904360.0 -1170000.0 -0.97 7717800.0 -1901915.0 -1.5992816240958 -2.2959 -0.9808 2141344 PK04_097017 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A20 compound treatment 7478240.0 -1640000.0 -1.42 7271760.0 -801000.0 -0.66 7903680.0 -1716035.0 -1.44297891430755 -2.0338 -0.9559 2141115 PK04_097018 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A21 compound treatment 6604480.0 -2520000.0 -2.17 6039040.0 -2030000.0 -1.69 7279880.0 -2339835.0 -1.96751964147514 -3.3612 -0.9949 2141570 PK04_097019 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A22 compound treatment 7488320.0 -1630000.0 -1.41 6332600.0 -1740000.0 -1.44 7199160.0 -2420555.0 -2.03539544701693 -2.8206 -0.9847 2141549 PK04_097020 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A23 compound treatment 3661000.0 -5460000.0 -4.7 4639720.0 -3430000.0 -2.85 3878280.0 -5741435.0 -4.82785586708159 -7.1454 -0.9768 2141876 PK04_097021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 A24 compound treatment 7334600.0 -1790000.0 -1.54 6419800.0 -1650000.0 -1.37 8110000.0 -1509715.0 -1.26948862442422 -2.413 -0.9968 2141753 PK04_097022 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B01 compound treatment 7214720.0 -1910000.0 -1.64 7187040.0 -885000.0 -0.73 8290720.0 -1328995.0 -1.11752485364236 -2.0174 -0.9526 2141940 PK04_097023 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B02 compound treatment 6523960.0 -2600000.0 -2.24 5766520.0 -2310000.0 -1.91 6861640.0 -2758075.0 -2.31920914729524 -3.7348 -0.9967 2142685 PK04_097024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B03 compound treatment 8063560.0 -1060000.0 -0.91 7323520.0 -749000.0 -0.62 8969640.0 -650075.0 -0.546634840034427 -1.2006 -0.9752 2141335 PK04_097025 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B04 compound treatment 7990000.0 -1130000.0 -0.97 7907000.0 -166000.0 -0.14 8948000.0 -671715.0 -0.56483147571238 -0.9682 -0.853 2143933 PK04_097026 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B05 compound treatment 8674080.0 -449000.0 -0.39 7091080.0 -981000.0 -0.81 8464440.0 -1155275.0 -0.971447240427294 -1.2539 -0.9463 2141445 PK04_097027 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B06 compound treatment 9038920.0 -83800.0 -0.07 7793440.0 -279000.0 -0.23 9191960.0 -427755.0 -0.359690475712689 -0.383 -0.8829 2144925 PK04_097028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B07 compound treatment 4023680.0 -5100000.0 -4.39 5212520.0 -2860000.0 -2.37 5046240.0 -4573475.0 -3.84574206826359 -6.1238 -0.9722 2141881 PK04_097029 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B08 compound treatment 8678720.0 -444000.0 -0.38 7684920.0 -388000.0 -0.32 9559920.0 -59795.0 -0.0502803988153038 -0.4353 -0.8672 2144289 PK04_097030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B09 compound treatment 7213960.0 -1910000.0 -1.64 6474920.0 -1600000.0 -1.33 8470480.0 -1149235.0 -0.966368327326793 -2.2716 -0.9785 2141150 PK04_097031 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B10 compound treatment 8378480.0 -744000.0 -0.64 7057920.0 -1010000.0 -0.84 8739080.0 -880635.0 -0.740508052691948 -1.2833 -0.9939 2144633 PK04_097032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B11 compound treatment 8744680.0 -378000.0 -0.33 7267000.0 -806000.0 -0.67 9642440.0 22725.0 0.0191089901008074 -0.5626 -0.7567 2141161 PK04_097033 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B12 compound treatment 9023000.0 -99800.0 -0.09 8212520.0 140000.0 0.12 9452400.0 -167315.0 -0.140691779041434 -0.0637 -0.3161 2144765 PK04_097034 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B13 mock treatment 9350680.0 228000.0 0.2 8046000.0 -26500.0 -0.02 9516880.0 -102835.0 -0.0864718590546327 0.0506 0.2349 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B14 mock treatment 9455200.0 332000.0 0.29 8134160.0 61600.0 0.05 9476360.0 -143355.0 -0.120544302569912 0.1251 0.3976 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B15 compound treatment 8773800.0 -349000.0 -0.3 7938720.0 -134000.0 -0.11 9220160.0 -399555.0 -0.335977669514988 -0.4315 -0.9296 2141135 PK04_097035 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B16 compound treatment 8786600.0 -336000.0 -0.29 7950440.0 -122000.0 -0.1 9348800.0 -270915.0 -0.227806911030153 -0.357 -0.9349 2144753 PK04_097036 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B17 compound treatment 7816600.0 -1310000.0 -1.12 7610720.0 -462000.0 -0.38 8572520.0 -1047195.0 -0.880564967595819 -1.3786 -0.9325 2141225 PK04_097037 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B18 compound treatment 911000.0 -8210000.0 -7.07 2976160.0 -5100000.0 -4.23 1366400.0 -8253315.0 -6.94004464835402 -10.5281 -0.9776 2144045 PK04_097038 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B19 compound treatment 7081280.0 -2040000.0 -1.76 6739200.0 -1330000.0 -1.11 7821800.0 -1797915.0 -1.51183014024612 -2.5258 -0.9835 2141420 PK04_097039 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B20 compound treatment 8342280.0 -780000.0 -0.67 7876680.0 -196000.0 -0.16 8867480.0 -752235.0 -0.63253910532369 -0.8468 -0.9039 2144377 PK04_097040 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B21 compound treatment 8334480.0 -788000.0 -0.68 7383040.0 -689000.0 -0.57 9126240.0 -493475.0 -0.414953086468468 -0.9615 -0.9815 2141808 PK04_097041 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B22 compound treatment 7909680.0 -1210000.0 -1.04 7807160.0 -265000.0 -0.22 9033720.0 -585995.0 -0.492751271908586 -1.0143 -0.8631 2143265 PK04_097042 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B23 compound treatment 7753360.0 -1370000.0 -1.18 7420560.0 -652000.0 -0.54 8583280.0 -1036435.0 -0.871517102535987 -1.4959 -0.9574 2141931 PK04_097043 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 B24 compound treatment 6378120.0 -2740000.0 -2.36 4497480.0 -3580000.0 -2.97 6833160.0 -2786555.0 -2.34315739979561 -4.4289 -0.9937 2142705 PK04_097044 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C01 compound treatment 7592000.0 -1530000.0 -1.32 6922760.0 -1150000.0 -0.95 7617040.0 -2002675.0 -1.6840086578717 -2.2836 -0.9754 2141223 PK04_097045 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C02 compound treatment 8974400.0 -148000.0 -0.13 7606880.0 -466000.0 -0.39 8792280.0 -827435.0 -0.695773255184227 -0.6984 -0.8666 2141108 PK04_097046 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C03 compound treatment 5639320.0 -3480000.0 -3.0 4868200.0 -3200000.0 -2.66 6983680.0 -2636035.0 -2.21658819451625 -4.5454 -0.9927 2141329 PK04_097047 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C04 compound treatment 9159520.0 36800.0 0.03 7917320.0 -155000.0 -0.13 9397480.0 -222235.0 -0.186872889551284 -0.164 -0.7156 2141703 PK04_097048 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C05 compound treatment 8321040.0 -802000.0 -0.69 7663760.0 -409000.0 -0.34 9028240.0 -591475.0 -0.497359292403743 -0.8813 -0.9625 2065845 PK04_097049 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C06 compound treatment 8948880.0 -174000.0 -0.15 8051160.0 -21400.0 -0.02 8937160.0 -682555.0 -0.573946611144404 -0.428 -0.7213 2141782 PK04_097050 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C07 compound treatment 8704640.0 -418000.0 -0.36 8360120.0 288000.0 0.24 8742000.0 -877715.0 -0.738052684106938 -0.4961 -0.5802 2141574 PK04_097051 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C08 compound treatment 8302920.0 -820000.0 -0.71 6959720.0 -1110000.0 -0.92 8525360.0 -1094355.0 -0.920220852003039 -1.4716 -0.9929 2141856 PK04_097052 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C09 compound treatment 8241480.0 -881000.0 -0.76 7258760.0 -814000.0 -0.68 8284560.0 -1335155.0 -1.12270467230114 -1.4758 -0.975 2141751 PK04_097053 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C10 compound treatment 9786320.0 664000.0 0.57 8084600.0 12100.0 0.01 9817880.0 198165.0 0.166632916317998 0.4317 0.7256 2141441 PK04_097054 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C11 mock treatment 8878920.0 -244000.0 -0.21 8582000.0 509000.0 0.42 9413760.0 -205955.0 -0.1731833688102 0.0229 0.0455 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C12 mock treatment 9683680.0 561000.0 0.48 8458120.0 386000.0 0.32 9867680.0 247965.0 0.208508723007556 0.5838 0.9485 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C13 compound treatment 8937840.0 -185000.0 -0.16 8042880.0 -29600.0 -0.02 9986320.0 366605.0 0.308270684968383 0.0719 0.2067 2141937 PK04_097055 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C14 compound treatment 1269080.0 -7850000.0 -6.76 5750680.0 -2320000.0 -1.93 8080440.0 -1539275.0 -1.29434502694919 -5.7618 -0.8062 2141727 PK04_097056 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C15 mock treatment 9293640.0 171000.0 0.15 7390360.0 -682000.0 -0.57 8966160.0 -653555.0 -0.549561101224782 -0.5591 -0.6968 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C16 mock treatment 9027400.0 -95400.0 -0.08 7765080.0 -307000.0 -0.26 9652440.0 32725.0 0.027517786624815 -0.1787 -0.6637 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C17 compound treatment 9144680.0 21900.0 0.02 7901120.0 -171000.0 -0.14 9148560.0 -471155.0 -0.396184652626883 -0.2999 -0.7118 2141078 PK04_097057 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C18 compound treatment 9307040.0 184000.0 0.16 8315720.0 243000.0 0.2 9528200.0 -91515.0 -0.076953101389456 0.1636 0.6107 2141467 PK04_097058 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C19 compound treatment 9242600.0 120000.0 0.1 7950120.0 -122000.0 -0.1 9676720.0 57005.0 0.0479343445851056 0.0286 0.1876 2141339 PK04_097059 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C20 compound treatment 2727320.0 -6400000.0 -5.5 2415000.0 -5660000.0 -4.69 4462880.0 -5156835.0 -4.3362776222881 -8.3911 -0.995 2141364 PK04_097060 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C21 compound treatment 3367560.0 -5760000.0 -4.95 4130240.0 -3940000.0 -3.27 4914480.0 -4705235.0 -3.95653637126391 -7.0322 -0.9858 2141370 PK04_097061 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C22 compound treatment 8312760.0 -810000.0 -0.7 7543040.0 -529000.0 -0.44 9362280.0 -257435.0 -0.216471853315791 -0.7811 -0.9168 2141489 PK04_097062 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C23 compound treatment 8057880.0 -1060000.0 -0.92 8095920.0 23400.0 0.02 9224640.0 -395075.0 -0.332210528672232 -0.7097 -0.7279 2141706 PK04_097063 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 C24 compound treatment 7942080.0 -1180000.0 -1.02 7353160.0 -719000.0 -0.6 8915280.0 -704435.0 -0.592345057938933 -1.2732 -0.9653 2141172 PK04_097064 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D01 compound treatment 8033520.0 -1090000.0 -0.94 7080640.0 -992000.0 -0.82 8993080.0 -626635.0 -0.526924620982154 -1.3205 -0.9752 2141788 PK04_097065 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D02 compound treatment 8799800.0 -323000.0 -0.28 8083080.0 10600.0 0.01 8927880.0 -691835.0 -0.581749974318683 -0.4913 -0.7619 2143973 PK04_097066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D03 compound treatment 9046960.0 -75800.0 -0.07 8335440.0 263000.0 0.22 9655440.0 35725.0 0.0300404255820173 0.1056 0.4599 2141854 PK04_097067 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D04 compound treatment 7396160.0 -1730000.0 -1.49 7324440.0 -748000.0 -0.62 8047640.0 -1572075.0 -1.32192587954793 -1.9794 -0.9501 2141969 PK04_097068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D05 compound treatment 9024520.0 -98200.0 -0.08 7882960.0 -190000.0 -0.16 1.007112E7 451405.0 0.379577279491967 0.0795 0.1896 2141087 PK04_097069 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D06 compound treatment 9173440.0 50700.0 0.04 7814200.0 -258000.0 -0.21 9232360.0 -387355.0 -0.325718937755698 -0.2866 -0.7305 2144657 PK04_097070 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D07 compound treatment 8466480.0 -656000.0 -0.56 8294600.0 222000.0 0.18 9545600.0 -74115.0 -0.0623217954376827 -0.2557 -0.4281 2141768 PK04_097071 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D08 compound treatment 5761600.0 -3360000.0 -2.89 5521200.0 -2550000.0 -2.12 4974160.0 -4645555.0 -3.90635267360864 -5.1474 -0.9709 2144733 PK04_097072 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D09 compound treatment 8645000.0 -478000.0 -0.41 8409080.0 337000.0 0.28 1.028428E7 664565.0 0.558819186197715 0.2464 0.3295 2141552 PK04_097073 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D10 compound treatment 5272440.0 -3850000.0 -3.31 5192560.0 -2880000.0 -2.39 6165360.0 -3454355.0 -2.90469683166885 -4.9696 -0.9914 2143885 PK04_097074 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D11 mock treatment 9022040.0 -101000.0 -0.09 8617440.0 545000.0 0.45 9750200.0 130485.0 0.109722181443514 0.2743 0.5797 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D12 mock treatment 9711440.0 589000.0 0.51 8605040.0 533000.0 0.44 1.030636E7 686645.0 0.577385808922723 0.8809 0.9941 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D13 compound treatment 9055320.0 -67400.0 -0.06 8571040.0 499000.0 0.41 9580720.0 -38995.0 -0.0327901020453678 0.1863 0.4448 2141513 PK04_097075 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D14 compound treatment 9225800.0 103000.0 0.09 8620760.0 548000.0 0.45 1.04538E7 834085.0 0.701365104872692 0.7187 0.855 2144449 PK04_097076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D15 mock treatment 9318080.0 195000.0 0.17 7896120.0 -176000.0 -0.15 9712480.0 92765.0 0.078004200954957 0.0576 0.244 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D16 mock treatment 9203000.0 80200.0 0.07 8203320.0 131000.0 0.11 1.05116E7 891885.0 0.749967948781456 0.5355 0.7038 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D17 compound treatment 9137840.0 15100.0 0.01 8358640.0 286000.0 0.24 1.025344E7 633725.0 0.532886457717675 0.4522 0.775 2141816 PK04_097077 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D18 compound treatment 8557800.0 -565000.0 -0.49 7357640.0 -715000.0 -0.59 9158120.0 -461595.0 -0.388145843149931 -0.8472 -0.9857 2142085 PK04_097078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D19 compound treatment 9653720.0 531000.0 0.46 8344960.0 272000.0 0.23 1.026732E7 647605.0 0.544557867292997 0.7087 0.9501 2141432 PK04_097079 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D20 compound treatment 9175280.0 52500.0 0.05 8561600.0 489000.0 0.41 9612760.0 -6955.0 -0.00584831798244732 0.257 0.6294 2144825 PK04_097080 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D21 compound treatment 8488520.0 -634000.0 -0.55 8051360.0 -21200.0 -0.02 9036960.0 -582755.0 -0.490026821834808 -0.6082 -0.8289 2141123 PK04_097081 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D22 compound treatment 5633560.0 -3490000.0 -3.0 5003800.0 -3070000.0 -2.55 5895440.0 -3724275.0 -3.13166706744486 -5.0116 -0.9962 2144893 PK04_097082 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D23 compound treatment 8051560.0 -1070000.0 -0.92 7379560.0 -693000.0 -0.57 8482760.0 -1136955.0 -0.956042325195312 -1.4161 -0.9785 2141421 PK04_097083 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 D24 compound treatment 8256000.0 -867000.0 -0.75 7077360.0 -995000.0 -0.83 8413200.0 -1206515.0 -1.01453391381631 -1.4931 -0.9916 2143085 PK04_097084 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E01 mock treatment 8136920.0 -986000.0 -0.85 7445600.0 -627000.0 -0.52 9183880.0 -435835.0 -0.366484783304088 -1.0017 -0.9446 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E02 mock treatment 8900040.0 -223000.0 -0.19 7831880.0 -241000.0 -0.2 9738480.0 118765.0 0.0998670719173769 -0.1683 -0.5719 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E03 compound treatment 5983040.0 -3140000.0 -2.7 5548600.0 -2520000.0 -2.09 6458520.0 -3161195.0 -2.65818455277104 -4.3036 -0.9938 2141878 PK04_097085 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E04 compound treatment 9770920.0 648000.0 0.56 8015160.0 -57400.0 -0.05 1.00472E7 427485.0 0.359463438206541 0.5021 0.7547 2141520 PK04_097086 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E05 compound treatment 1583680.0 -7540000.0 -6.49 1475040.0 -6600000.0 -5.47 1943440.0 -7676275.0 -6.45482345373268 -10.6327 -0.9971 2141359 PK04_097087 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E06 compound treatment 7449000.0 -1670000.0 -1.44 7628120.0 -444000.0 -0.37 8853960.0 -765755.0 -0.643907798224148 -1.4163 -0.8741 2141507 PK04_097088 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E07 compound treatment 9390960.0 268000.0 0.23 8367760.0 295000.0 0.24 9992200.0 372485.0 0.313215057324499 0.4555 0.9908 2141863 PK04_097089 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E08 compound treatment 9908480.0 786000.0 0.68 8188920.0 116000.0 0.1 1.034284E7 723125.0 0.608061098642303 0.7972 0.8718 2141163 PK04_097090 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E09 mock treatment 9102320.0 -20400.0 -0.02 8505800.0 433000.0 0.36 9987920.0 368205.0 0.309616092412224 0.3761 0.7923 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E10 mock treatment 9686520.0 564000.0 0.49 8393760.0 321000.0 0.27 1.00424E7 422685.0 0.355427215875017 0.6392 0.9716 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E11 compound treatment 9682240.0 559000.0 0.48 8135960.0 63400.0 0.05 9942040.0 322325.0 0.271036533960077 0.4649 0.8375 2141456 PK04_097091 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E12 compound treatment 993000.0 -8130000.0 -7.0 1732040.0 -6340000.0 -5.26 1396040.0 -8223675.0 -6.91512097545686 -11.0688 -0.9923 2141683 PK04_097092 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E13 compound treatment 1.01746E7 1050000.0 0.91 8515960.0 443000.0 0.37 1.065536E7 1035645.0 0.87085280761059 1.2378 0.9457 2141357 PK04_097093 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E14 compound treatment 4462320.0 -4660000.0 -4.01 3476000.0 -4600000.0 -3.81 5055640.0 -4564075.0 -3.83783779953102 -6.733 -0.9997 2141366 PK04_097094 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E15 compound treatment 9526120.0 403000.0 0.35 8190560.0 118000.0 0.1 9118400.0 -501315.0 -0.42154558294329 0.0136 0.0245 2141575 PK04_097095 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E16 compound treatment 9262320.0 140000.0 0.12 8239960.0 167000.0 0.14 1.007884E7 459125.0 0.386068870408501 0.3724 0.8712 2141485 PK04_097096 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E17 mock treatment 9313160.0 190000.0 0.16 7990400.0 -82100.0 -0.07 1.022576E7 606045.0 0.509610908939222 0.3495 0.6477 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E18 mock treatment 9401920.0 279000.0 0.24 7999280.0 -73200.0 -0.06 1.008924E7 469525.0 0.394814018793469 0.3316 0.7113 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E19 compound treatment 8535440.0 -587000.0 -0.51 7695520.0 -377000.0 -0.31 9500240.0 -119475.0 -0.100464096470581 -0.5304 -0.8799 2141377 PK04_097097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E20 compound treatment 4795200.0 -4330000.0 -3.72 4790600.0 -3280000.0 -2.72 5142040.0 -4477675.0 -3.7651857975636 -5.896 -0.9901 2141326 PK04_097098 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E21 compound treatment 7570480.0 -1550000.0 -1.34 6621880.0 -1450000.0 -1.2 7203200.0 -2416515.0 -2.03199829322124 -2.6393 -0.9727 2141702 PK04_097099 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E22 compound treatment 8014280.0 -1110000.0 -0.95 6793120.0 -1280000.0 -1.06 7932200.0 -1687515.0 -1.41899702662108 -1.9828 -0.9853 2141417 PK04_097100 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E23 compound treatment 9112440.0 -10300.0 -0.01 7861680.0 -211000.0 -0.17 9498360.0 -121355.0 -0.102044950217095 -0.165 -0.8142 2141167 PK04_097101 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 E24 compound treatment 7536000.0 -1590000.0 -1.37 7090840.0 -982000.0 -0.81 8202560.0 -1417155.0 -1.19165680379801 -1.9466 -0.9797 2141113 PK04_097102 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F01 mock treatment 8181360.0 -941000.0 -0.81 6938760.0 -1130000.0 -0.94 8743480.0 -876235.0 -0.736808182221384 -1.4362 -0.9949 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F02 mock treatment 9051400.0 -71400.0 -0.06 7620000.0 -453000.0 -0.38 9235560.0 -384155.0 -0.323028122868016 -0.4387 -0.8791 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F03 compound treatment 5824760.0 -3300000.0 -2.84 5763040.0 -2310000.0 -1.92 6334240.0 -3285475.0 -2.7626890759714 -4.3399 -0.9864 2141216 PK04_097103 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F04 compound treatment 9060160.0 -62600.0 -0.05 7651960.0 -421000.0 -0.35 9298040.0 -321675.0 -0.270489962186016 -0.3887 -0.874 2142933 PK04_097104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F05 compound treatment 8990440.0 -132000.0 -0.11 7348720.0 -724000.0 -0.6 9379000.0 -240715.0 -0.20241234552765 -0.5293 -0.8221 2141355 PK04_097105 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F06 compound treatment 8077960.0 -1040000.0 -0.9 7680480.0 -392000.0 -0.33 8581600.0 -1038115.0 -0.87292978035202 -1.2109 -0.9353 2142833 PK04_097106 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F07 compound treatment 8146360.0 -976000.0 -0.84 7749440.0 -323000.0 -0.27 9195880.0 -423835.0 -0.356394227475278 -0.8457 -0.8889 2141414 PK04_097107 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F08 compound treatment 9276400.0 154000.0 0.13 8517960.0 445000.0 0.37 1.005724E7 437525.0 0.367905869916645 0.5021 0.9334 2144249 PK04_097108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F09 mock treatment 9016640.0 -106000.0 -0.09 8374680.0 302000.0 0.25 9862800.0 243085.0 0.20440523030384 0.21 0.6248 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F10 mock treatment 9206080.0 83300.0 0.07 8813320.0 741000.0 0.61 9921720.0 302005.0 0.253949859423293 0.5428 0.8116 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F11 compound treatment 6051480.0 -3070000.0 -2.64 5503320.0 -2570000.0 -2.13 6353160.0 -3266555.0 -2.74677963294798 -4.3425 -0.9943 2141568 PK04_097109 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F12 compound treatment 1137080.0 -7990000.0 -6.87 1618000.0 -6450000.0 -5.35 932680.0 -8687035.0 -7.30475097119328 -11.2768 -0.9918 2142765 PK04_097110 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F13 compound treatment 8261960.0 -861000.0 -0.74 7995520.0 -77000.0 -0.06 9028200.0 -591515.0 -0.497392927589839 -0.7518 -0.8403 2141348 PK04_097111 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F14 compound treatment 9150560.0 27800.0 0.02 8472600.0 400000.0 0.33 1.01872E7 567485.0 0.477186589542648 0.4809 0.8267 2142645 PK04_097112 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F15 compound treatment 9186480.0 63700.0 0.05 7673880.0 -399000.0 -0.33 9887040.0 267325.0 0.224788153078035 -0.0295 -0.0731 2141505 PK04_097113 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F16 compound treatment 9662800.0 540000.0 0.46 8458200.0 386000.0 0.32 9958720.0 339005.0 0.285062406562121 0.6176 0.977 2142977 PK04_097114 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F17 mock treatment 9632680.0 510000.0 0.44 8660840.0 588000.0 0.49 9889960.0 270245.0 0.227243521663045 0.6664 0.9594 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F18 mock treatment 9611040.0 488000.0 0.42 8474000.0 401000.0 0.33 1.02282E7 608485.0 0.51166265529108 0.7303 0.9854 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F19 compound treatment 9145800.0 23000.0 0.02 8475840.0 403000.0 0.33 9833280.0 213565.0 0.179582462964969 0.3083 0.8108 2141200 PK04_097115 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F20 compound treatment 8894760.0 -228000.0 -0.2 7487800.0 -585000.0 -0.49 9155200.0 -464515.0 -0.390601211734941 -0.6189 -0.9478 2142045 PK04_097116 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F21 compound treatment 8140000.0 -983000.0 -0.85 7716560.0 -356000.0 -0.3 9094120.0 -525595.0 -0.44196214090358 -0.914 -0.9149 2141938 PK04_097117 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F22 compound treatment 9384440.0 262000.0 0.23 8302520.0 230000.0 0.19 9620880.0 1165.0 9.79624795046892E-4 0.2408 0.8156 2144373 PK04_097118 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F23 compound treatment 7302400.0 -1820000.0 -1.57 7287240.0 -785000.0 -0.65 8521200.0 -1098515.0 -0.923718911357027 -1.8139 -0.939 2141419 PK04_097119 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 F24 compound treatment 6940560.0 -2180000.0 -1.88 6271640.0 -1800000.0 -1.49 7468480.0 -2151235.0 -1.80892973903236 -2.9912 -0.9953 2142769 PK04_097120 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G01 compound treatment 8185000.0 -938000.0 -0.81 7167000.0 -906000.0 -0.75 8823960.0 -795755.0 -0.669134187796171 -1.286 -0.9971 2141178 PK04_097121 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G02 compound treatment 7568840.0 -1550000.0 -1.34 7262240.0 -810000.0 -0.67 8536320.0 -1083395.0 -0.911004811012727 -1.6862 -0.9623 2141487 PK04_097122 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G03 mock treatment 8633760.0 -489000.0 -0.42 8375720.0 303000.0 0.25 9129520.0 -490195.0 -0.412195001208593 -0.3357 -0.5241 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G04 mock treatment 8877280.0 -245000.0 -0.21 8127960.0 55400.0 0.05 9078560.0 -541155.0 -0.455046228294936 -0.3581 -0.7109 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G05 compound treatment 8836720.0 -286000.0 -0.25 8151080.0 78600.0 0.07 9514680.0 -105035.0 -0.0883217942899144 -0.1555 -0.5769 2141519 PK04_097123 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G06 compound treatment 9531880.0 409000.0 0.35 9892040.0 1820000.0 1.51 9621240.0 1525.0 0.00128234146991117 1.0755 0.6939 2141537 PK04_097124 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G07 compound treatment 4502200.0 -4620000.0 -3.98 5339040.0 -2730000.0 -2.27 5214040.0 -4405675.0 -3.70464246259074 -5.744 -0.9754 2141722 PK04_097125 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G08 compound treatment 8579920.0 -543000.0 -0.47 8018600.0 -53900.0 -0.04 9657560.0 37845.0 0.031823090445107 -0.2772 -0.5892 2141577 PK04_097126 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G09 compound treatment 9966960.0 844000.0 0.73 8107440.0 34900.0 0.03 1.006E7 440285.0 0.370226697757271 0.65 0.7966 2141458 PK04_097127 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G10 compound treatment 9783160.0 660000.0 0.57 8606640.0 534000.0 0.44 1.082324E7 1203525.0 1.01201968365563 1.1683 0.9403 2141190 PK04_097128 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G11 compound treatment 8766960.0 -356000.0 -0.31 8103840.0 31300.0 0.03 9728960.0 109245.0 0.0918618976265216 -0.1088 -0.3391 2141333 PK04_097129 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G12 compound treatment 9454960.0 332000.0 0.29 8842720.0 770000.0 0.64 9737040.0 117325.0 0.0986562052179198 0.5909 0.8359 2141508 PK04_097130 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G13 compound treatment 9333480.0 211000.0 0.18 8559400.0 487000.0 0.4 1.018444E7 564725.0 0.474865761702022 0.6121 0.9427 2141118 PK04_097131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G14 compound treatment 6748560.0 -2370000.0 -2.04 5477920.0 -2590000.0 -2.15 6981840.0 -2637875.0 -2.21813541307667 -3.703 -0.9994 2141927 PK04_097132 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G15 compound treatment 9291600.0 169000.0 0.15 7763960.0 -309000.0 -0.26 1.021404E7 594325.0 0.499755799413085 0.2246 0.3873 2141159 PK04_097133 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G16 compound treatment 8585040.0 -538000.0 -0.46 7700800.0 -372000.0 -0.31 9408960.0 -210755.0 -0.177219591141723 -0.5475 -0.9381 2141713 PK04_097134 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G17 compound treatment 9384920.0 262000.0 0.23 8624720.0 552000.0 0.46 1.036492E7 745205.0 0.626627721367312 0.7565 0.9359 2141795 PK04_097135 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G18 compound treatment 1.046464E7 1340000.0 1.15 8096160.0 23600.0 0.02 9819040.0 199325.0 0.167608336714783 0.7749 0.6639 2141553 PK04_097136 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G19 mock treatment 9182800.0 60000.0 0.05 8182040.0 110000.0 0.09 9628080.0 8365.0 0.0070339582923324 0.0864 0.8243 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G20 mock treatment 9458840.0 336000.0 0.29 8540920.0 468000.0 0.39 9975120.0 355405.0 0.298852832861494 0.5639 0.9907 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G21 compound treatment 8790400.0 -332000.0 -0.29 8072960.0 448.0 0.0 9593720.0 -25995.0 -0.0218586665641579 -0.1776 -0.6189 2141819 PK04_097137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G22 compound treatment 9022240.0 -101000.0 -0.09 8155360.0 82800.0 0.07 8880280.0 -739435.0 -0.62177584577296 -0.3693 -0.5847 2141516 PK04_097138 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G23 compound treatment 9131680.0 8920.0 0.01 7997320.0 -75200.0 -0.06 9707480.0 87765.0 0.0737998026929532 0.011 0.1138 2141691 PK04_097139 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 G24 compound treatment 4357120.0 -4770000.0 -4.1 4295360.0 -3780000.0 -3.13 5079680.0 -4540035.0 -3.81762305268731 -6.3812 -0.994 2141155 PK04_097140 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H01 compound treatment 8495360.0 -627000.0 -0.54 7342440.0 -730000.0 -0.61 8422360.0 -1197355.0 -1.00683145620032 -1.2427 -0.961 2141157 PK04_097141 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H02 compound treatment 8204280.0 -918000.0 -0.79 7828240.0 -244000.0 -0.2 9473240.0 -146475.0 -0.123167847085402 -0.6445 -0.7809 2143037 PK04_097142 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H03 mock treatment 8920240.0 -203000.0 -0.17 8017840.0 -54700.0 -0.05 9382520.0 -237195.0 -0.1994524491512 -0.242 -0.9004 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H04 mock treatment 8910440.0 -212000.0 -0.18 8462120.0 390000.0 0.32 9536400.0 -83315.0 -0.0700578882397697 0.0407 0.1076 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H05 compound treatment 4332040.0 -4790000.0 -4.12 4578400.0 -3490000.0 -2.9 5691600.0 -3928115.0 -3.30307197579023 -5.961 -0.9892 2141926 PK04_097143 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H06 compound treatment 9352040.0 229000.0 0.2 7700920.0 -372000.0 -0.31 1.005432E7 434605.0 0.365450501331635 0.1469 0.2841 2143177 PK04_097144 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H07 compound treatment 9212440.0 89700.0 0.08 8272520.0 200000.0 0.17 1.018848E7 568765.0 0.478262915497721 0.4165 0.8133 2141694 PK04_097145 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H08 compound treatment 3997560.0 -5130000.0 -4.41 4044600.0 -4030000.0 -3.34 4389640.0 -5230075.0 -4.39786364802993 -7.015 -0.9924 2143025 PK04_097146 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H09 compound treatment 419960.0 -8700000.0 -7.49 1032520.0 -7040000.0 -5.84 675080.0 -8944635.0 -7.52136156965172 -12.0386 -0.9937 2141749 PK04_097147 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H10 compound treatment 9842960.0 720000.0 0.62 8376440.0 304000.0 0.25 1.01896E7 569885.0 0.47920470070841 0.7801 0.9478 2143077 PK04_097148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H11 compound treatment 8684280.0 -438000.0 -0.38 8554560.0 482000.0 0.4 1.00964E7 476685.0 0.400834717104659 0.2444 0.3592 2141097 PK04_097149 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H12 compound treatment 9951840.0 829000.0 0.71 9241880.0 1170000.0 0.97 1.051088E7 891165.0 0.749362515431728 1.4047 0.9904 2142913 PK04_097150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H13 compound treatment 9119400.0 -3360.0 0.0 8289360.0 217000.0 0.18 9798360.0 178645.0 0.150218945503135 0.1889 0.806 2141401 PK04_097151 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H14 compound treatment 9501520.0 379000.0 0.33 8588000.0 515000.0 0.43 9995400.0 375685.0 0.315905872212181 0.6175 0.9901 2143093 PK04_097152 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H15 compound treatment 9681680.0 559000.0 0.48 8533120.0 461000.0 0.38 1.118148E7 1561765.0 1.31325641033168 1.2565 0.8667 2141777 PK04_097153 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H16 compound treatment 8819400.0 -303000.0 -0.26 7683480.0 -389000.0 -0.32 9642480.0 22765.0 0.0191426252869034 -0.326 -0.7845 2143865 PK04_097154 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H17 compound treatment 9792200.0 669000.0 0.58 8018520.0 -54000.0 -0.04 9950640.0 330925.0 0.278268098970723 0.4674 0.7288 2141142 PK04_097155 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H18 compound treatment 9568400.0 446000.0 0.38 8774320.0 702000.0 0.58 1.032608E7 706365.0 0.593967955668066 0.9005 0.9832 2143925 PK04_097156 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H19 mock treatment 9764040.0 641000.0 0.55 8387800.0 315000.0 0.26 1.023976E7 620045.0 0.521383224072832 0.7707 0.9597 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H20 mock treatment 9994880.0 872000.0 0.75 8090960.0 18400.0 0.02 9980840.0 361125.0 0.303662664473226 0.6175 0.7625 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H21 compound treatment 9357080.0 234000.0 0.2 8349400.0 277000.0 0.23 9441520.0 -178195.0 -0.149840549659554 0.1625 0.4775 2141168 PK04_097157 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H22 compound treatment 8942480.0 -180000.0 -0.16 8199600.0 127000.0 0.11 9551160.0 -68555.0 -0.0576465045703345 -0.062 -0.3159 2143057 PK04_097158 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H23 compound treatment 9440840.0 318000.0 0.27 7935080.0 -137000.0 -0.11 9234800.0 -384915.0 -0.323667191403841 -0.0946 -0.2156 2141804 PK04_097159 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 H24 compound treatment 8603280.0 -519000.0 -0.45 8115400.0 42900.0 0.04 9398160.0 -221555.0 -0.186301091387652 -0.3451 -0.7107 2142649 PK04_097160 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I01 compound treatment 8424000.0 -699000.0 -0.6 7806880.0 -266000.0 -0.22 8474600.0 -1145115.0 -0.962903903158902 -1.0304 -0.891 2141890 PK04_097161 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I02 compound treatment 8120320.0 -1000000.0 -0.86 7847480.0 -225000.0 -0.19 9175760.0 -443955.0 -0.373312726081582 -0.8214 -0.8571 2141465 PK04_097162 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I03 compound treatment 8753800.0 -369000.0 -0.32 7583800.0 -489000.0 -0.41 9859160.0 239445.0 0.201344428369101 -0.3012 -0.5447 2141772 PK04_097163 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I04 compound treatment 8611320.0 -511000.0 -0.44 7784480.0 -288000.0 -0.24 9525800.0 -93915.0 -0.0789712125552179 -0.4377 -0.8632 2141343 PK04_097164 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I05 mock treatment 9098520.0 -24200.0 -0.02 7513840.0 -559000.0 -0.46 8971920.0 -647795.0 -0.544717634426954 -0.5941 -0.8303 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I06 mock treatment 9770120.0 647000.0 0.56 7894280.0 -178000.0 -0.15 9800440.0 180725.0 0.151967975180128 0.324 0.5436 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I07 compound treatment 9904720.0 782000.0 0.67 8849040.0 777000.0 0.64 1.017288E7 553165.0 0.465145192920269 1.029 0.9882 2141794 PK04_097165 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I08 compound treatment 7268000.0 -1850000.0 -1.6 6388000.0 -1680000.0 -1.4 7633360.0 -1986355.0 -1.67028550194452 -2.6928 -0.9973 2141922 PK04_097166 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I09 compound treatment 9922080.0 799000.0 0.69 8246280.0 174000.0 0.14 1.026044E7 640725.0 0.53877261528448 0.7915 0.8937 2141780 PK04_097167 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I10 compound treatment 9541000.0 418000.0 0.36 7705200.0 -367000.0 -0.3 8820440.0 -799275.0 -0.672094084172622 -0.3561 -0.4338 2141799 PK04_097168 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I11 compound treatment 9372400.0 250000.0 0.21 7854960.0 -218000.0 -0.18 1.01172E7 497485.0 0.418325013874595 0.2614 0.5189 2141177 PK04_097169 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I12 compound treatment 6927440.0 -2200000.0 -1.89 5782400.0 -2290000.0 -1.9 7563160.0 -2056555.0 -1.72931525354306 -3.1861 -0.9991 2141747 PK04_097170 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I13 compound treatment 9754880.0 632000.0 0.54 8152560.0 80000.0 0.07 9933520.0 313805.0 0.263872239321622 0.5048 0.8298 2141423 PK04_097171 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I14 compound treatment 1.047816E7 1360000.0 1.17 8464480.0 392000.0 0.33 1.044832E7 828605.0 0.696757084377536 1.2635 0.9044 2141775 PK04_097172 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I15 compound treatment 9791000.0 668000.0 0.58 7799240.0 -273000.0 -0.23 9778960.0 159245.0 0.13390588024656 0.2785 0.4403 2141538 PK04_097173 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I16 compound treatment 9754320.0 632000.0 0.54 7950920.0 -122000.0 -0.1 1.033144E7 711725.0 0.598475070604935 0.6011 0.7378 2065871 PK04_097174 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I17 compound treatment 9482000.0 359000.0 0.31 7869520.0 -203000.0 -0.17 9525240.0 -94475.0 -0.0794421051605623 0.0354 0.0981 2141729 PK04_097175 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I18 compound treatment 1.004812E7 925000.0 0.8 8539640.0 467000.0 0.39 9594360.0 -25355.0 -0.0213205035866214 0.6712 0.7576 2141892 PK04_097176 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I19 compound treatment 9116600.0 -6160.0 -0.01 8170400.0 97900.0 0.08 9584120.0 -35595.0 -0.0299311112272052 0.0265 0.3061 2141687 PK04_097177 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I20 compound treatment 9713720.0 591000.0 0.51 8592240.0 520000.0 0.43 9641240.0 21525.0 0.0180999345179265 0.553 0.8291 2141680 PK04_097178 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I21 mock treatment 9497360.0 375000.0 0.32 7906680.0 -166000.0 -0.14 9286720.0 -332995.0 -0.280008719851193 -0.055 -0.1225 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I22 mock treatment 8691920.0 -431000.0 -0.37 8384040.0 312000.0 0.26 9150920.0 -468795.0 -0.394200176647217 -0.2925 -0.4877 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I23 compound treatment 8891280.0 -231000.0 -0.2 7918040.0 -154000.0 -0.13 9369200.0 -250515.0 -0.210652966121178 -0.3106 -0.9799 2141841 PK04_097179 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 I24 compound treatment 5145880.0 -3980000.0 -3.42 5360440.0 -2710000.0 -2.25 5391840.0 -4227875.0 -3.55513406039389 -5.3276 -0.9823 2141766 PK04_097180 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J01 compound treatment 8166640.0 -956000.0 -0.82 6579680.0 -1490000.0 -1.24 7983400.0 -1636315.0 -1.37594398841816 -1.9845 -0.9796 2141705 PK04_097181 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J02 compound treatment 7713760.0 -1410000.0 -1.21 7043200.0 -1030000.0 -0.85 8879240.0 -740475.0 -0.622650360611457 -1.5526 -0.9652 2143397 PK04_097182 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J03 compound treatment 8876440.0 -246000.0 -0.21 7743800.0 -329000.0 -0.27 9534200.0 -85515.0 -0.0719078234750514 -0.3213 -0.9108 2141179 PK04_097183 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J04 compound treatment 8848800.0 -274000.0 -0.24 8177920.0 105000.0 0.09 9430120.0 -189595.0 -0.159426577696923 -0.1777 -0.5968 2144337 PK04_097184 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J05 mock treatment 8210720.0 -912000.0 -0.78 7924120.0 -148000.0 -0.12 9486840.0 -132875.0 -0.111731883812752 -0.5888 -0.7338 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J06 mock treatment 8472080.0 -651000.0 -0.56 8026600.0 -45900.0 -0.04 9748560.0 128845.0 0.108343138813577 -0.2828 -0.4946 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J07 compound treatment 9644960.0 522000.0 0.45 7887440.0 -185000.0 -0.15 1.035264E7 732925.0 0.616301719235831 0.5267 0.6769 2141805 PK04_097185 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J08 compound treatment 9762440.0 640000.0 0.55 7792320.0 -280000.0 -0.23 1.005312E7 433405.0 0.364441445748754 0.3941 0.563 2143365 PK04_097186 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J09 compound treatment 9143720.0 21000.0 0.02 7909760.0 -163000.0 -0.14 9277600.0 -342115.0 -0.287677542281088 -0.2336 -0.734 2141901 PK04_097187 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J10 compound treatment 8412840.0 -710000.0 -0.61 7750560.0 -322000.0 -0.27 9201880.0 -417835.0 -0.351348949560874 -0.7098 -0.9417 2144881 PK04_097188 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J11 compound treatment 7016520.0 -2110000.0 -1.81 6315000.0 -1760000.0 -1.46 6715200.0 -2904515.0 -2.44234756359281 -3.2984 -0.9779 2141717 PK04_097189 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J12 compound treatment 7353040.0 -1770000.0 -1.52 6702640.0 -1370000.0 -1.14 6880840.0 -2738875.0 -2.30306425796915 -2.8651 -0.9596 2143405 PK04_097190 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J13 compound treatment 9954840.0 832000.0 0.72 8556000.0 483000.0 0.4 1.029024E7 670525.0 0.563830828926023 0.9705 0.9746 2141188 PK04_097191 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J14 compound treatment 8617640.0 -505000.0 -0.43 8033120.0 -39400.0 -0.03 1.029272E7 673005.0 0.565916210463977 0.0569 0.0796 2142929 PK04_097192 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J15 compound treatment 9352120.0 229000.0 0.2 8290360.0 218000.0 0.18 9634120.0 14405.0 0.012112871392833 0.2253 0.841 2141365 PK04_097193 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J16 compound treatment 9377960.0 255000.0 0.22 7768160.0 -304000.0 -0.25 8654680.0 -965035.0 -0.811478295354572 -0.4875 -0.5554 2144325 PK04_097194 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J17 compound treatment 3539320.0 -5580000.0 -4.81 3554680.0 -4520000.0 -3.75 4343520.0 -5276195.0 -4.43664501759866 -7.4997 -0.9949 2141221 PK04_097195 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J18 compound treatment 9255800.0 133000.0 0.11 8921760.0 849000.0 0.7 1.006852E7 448805.0 0.377390992395725 0.6907 0.8555 2143377 PK04_097196 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J19 compound treatment 9810240.0 687000.0 0.59 7771640.0 -301000.0 -0.25 9854040.0 234325.0 0.197039124548809 0.3113 0.4634 2141815 PK04_097197 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J20 compound treatment 8080200.0 -1040000.0 -0.9 7213480.0 -859000.0 -0.71 8604600.0 -1015115.0 -0.853589548346803 -1.4223 -0.9954 2142585 PK04_097198 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J21 mock treatment 9521840.0 399000.0 0.34 7996320.0 -76200.0 -0.06 9392240.0 -227475.0 -0.191279098929864 0.0514 0.129 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J22 mock treatment 8881680.0 -241000.0 -0.21 7872000.0 -201000.0 -0.17 9628440.0 8725.0 0.00733667496719668 -0.2116 -0.7954 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J23 compound treatment 8652880.0 -470000.0 -0.4 7584840.0 -488000.0 -0.4 9057680.0 -562035.0 -0.472603795437064 -0.7399 -0.9972 2141186 PK04_097199 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 J24 compound treatment 7854560.0 -1270000.0 -1.09 7374840.0 -698000.0 -0.58 8359320.0 -1260395.0 -1.05984050948766 -1.5762 -0.9683 2144237 PK04_097200 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K01 compound treatment 8409560.0 -713000.0 -0.61 7508720.0 -564000.0 -0.47 7955000.0 -1664715.0 -1.39982497054634 -1.4326 -0.8962 2141164 PK04_097201 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K02 compound treatment 7891440.0 -1230000.0 -1.06 8117160.0 44600.0 0.04 9599880.0 -19835.0 -0.0166788479053692 -0.6001 -0.5658 2141443 PK04_097202 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K03 compound treatment 8062320.0 -1060000.0 -0.91 7503640.0 -569000.0 -0.47 8913960.0 -705755.0 -0.593455019080102 -1.142 -0.9625 2141548 PK04_097203 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K04 compound treatment 9220040.0 97300.0 0.08 8381280.0 309000.0 0.26 9657080.0 37365.0 0.0314194682119546 0.2144 0.7901 2141351 PK04_097204 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K05 compound treatment 9658640.0 536000.0 0.46 8104040.0 31500.0 0.03 9543640.0 -76075.0 -0.0639699195563882 0.2444 0.5242 2141786 PK04_097205 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K06 compound treatment 7895160.0 -1230000.0 -1.06 7568680.0 -504000.0 -0.42 9575920.0 -43795.0 -0.0368263243768915 -0.8726 -0.7676 2141746 PK04_097206 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K07 mock treatment 9958240.0 835000.0 0.72 7742560.0 -330000.0 -0.27 1.037772E7 758005.0 0.637390980918042 0.6251 0.6257 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K08 mock treatment 9646280.0 524000.0 0.45 8101560.0 29000.0 0.02 9993040.0 373325.0 0.313921396232516 0.4553 0.8283 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K09 compound treatment 4466040.0 -4660000.0 -4.01 4180560.0 -3890000.0 -3.23 5157480.0 -4462235.0 -3.75220261573053 -6.3443 -0.9961 2141350 PK04_097207 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K10 compound treatment 1440400.0 -7680000.0 -6.61 1527800.0 -6540000.0 -5.43 1259200.0 -8360515.0 -7.03018694709138 -11.0108 -0.9944 2141331 PK04_097208 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K11 compound treatment 9732640.0 610000.0 0.52 8263120.0 191000.0 0.16 9767080.0 147365.0 0.123916229976039 0.4659 0.8289 2141806 PK04_097209 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K12 compound treatment 9752160.0 629000.0 0.54 8399040.0 327000.0 0.27 1.017452E7 554805.0 0.466524235550207 0.7385 0.966 2141720 PK04_097210 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K13 compound treatment 9550160.0 427000.0 0.37 7628600.0 -444000.0 -0.37 9592040.0 -27675.0 -0.0232713443801912 -0.0137 -0.0263 2141904 PK04_097211 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K14 compound treatment 9316520.0 194000.0 0.17 8182280.0 110000.0 0.09 9365800.0 -253915.0 -0.21351195693934 0.0256 0.0895 2141222 PK04_097212 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K15 mock treatment 9890520.0 768000.0 0.66 7609000.0 -464000.0 -0.38 9912560.0 292845.0 0.246247401807302 0.3017 0.3756 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K16 mock treatment 9446640.0 324000.0 0.28 7930120.0 -142000.0 -0.12 9472360.0 -147355.0 -0.123907821179515 0.0212 0.0648 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K17 compound treatment 9256800.0 134000.0 0.12 7707240.0 -365000.0 -0.3 9638640.0 18925.0 0.0159136474216845 -0.0992 -0.3055 2141773 PK04_097213 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K18 compound treatment 9181120.0 58400.0 0.05 8362520.0 290000.0 0.24 9896840.0 277125.0 0.233028773671562 0.3024 0.893 2141524 PK04_097214 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K19 compound treatment 8261280.0 -861000.0 -0.74 7311240.0 -761000.0 -0.63 8751240.0 -868475.0 -0.730282956118754 -1.2143 -0.9975 2141218 PK04_097215 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K20 compound treatment 8904560.0 -218000.0 -0.19 7751920.0 -321000.0 -0.27 9028480.0 -591235.0 -0.497157481287166 -0.549 -0.9238 2141861 PK04_097216 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K21 compound treatment 9286120.0 163000.0 0.14 8175360.0 103000.0 0.09 9304840.0 -314875.0 -0.264771980549691 -0.0224 -0.072 2141117 PK04_097217 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K22 compound treatment 8546480.0 -576000.0 -0.5 7844040.0 -228000.0 -0.19 9342320.0 -277395.0 -0.23325581117771 -0.5304 -0.9147 2141354 PK04_097218 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K23 mock treatment 8991800.0 -131000.0 -0.11 8169040.0 96500.0 0.08 8878000.0 -741715.0 -0.623693051380434 -0.3789 -0.5932 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 K24 mock treatment 8556760.0 -566000.0 -0.49 7868240.0 -204000.0 -0.17 8935040.0 -684675.0 -0.575729276007494 -0.7115 -0.9205 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L01 compound treatment 6984560.0 -2140000.0 -1.84 6631080.0 -1440000.0 -1.2 7661680.0 -1958035.0 -1.64647179018853 -2.7034 -0.9854 2141684 PK04_097219 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L02 compound treatment 8486400.0 -636000.0 -0.55 7686480.0 -386000.0 -0.32 9384800.0 -234915.0 -0.197535243543726 -0.6151 -0.9258 2143489 PK04_097220 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L03 compound treatment 205720.0 -8920000.0 -7.67 189840.0 -7880000.0 -6.54 205440.0 -9414275.0 -7.91627228960521 -12.7767 -0.9967 2141375 PK04_097221 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L04 compound treatment 9105320.0 -17400.0 -0.02 7780000.0 -293000.0 -0.24 9477400.0 -142315.0 -0.119669787731415 -0.2179 -0.804 2143313 PK04_097222 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L05 compound treatment 6947560.0 -2180000.0 -1.87 6468120.0 -1600000.0 -1.33 7616480.0 -2003235.0 -1.68447955047705 -2.8218 -0.9907 2141889 PK04_097223 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L06 compound treatment 7473760.0 -1650000.0 -1.42 7022920.0 -1050000.0 -0.87 8567920.0 -1051795.0 -0.884433013996863 -1.8327 -0.9721 2144793 PK04_097224 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L07 mock treatment 8068360.0 -1050000.0 -0.91 6205000.0 -1870000.0 -1.55 8943920.0 -675795.0 -0.568262264694175 -1.7465 -0.9274 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L08 mock treatment 8917640.0 -205000.0 -0.18 8502520.0 430000.0 0.36 1.000064E7 380925.0 0.320312081590761 0.289 0.5656 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L09 compound treatment 9118480.0 -4280.0 0.0 8439800.0 367000.0 0.3 1.035304E7 733325.0 0.616638071096791 0.5298 0.7703 2141438 PK04_097225 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L10 compound treatment 9457920.0 335000.0 0.29 8495480.0 423000.0 0.35 1.063928E7 1019565.0 0.857331462799986 0.8641 0.8906 2142993 PK04_097226 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L11 compound treatment 8223240.0 -900000.0 -0.77 7693800.0 -379000.0 -0.31 9522920.0 -96795.0 -0.0813929459541321 -0.6753 -0.8045 2141185 PK04_097227 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L12 compound treatment 9260040.0 137000.0 0.12 8274600.0 202000.0 0.17 1.051556E7 895845.0 0.753297832204963 0.5999 0.7684 2144653 PK04_097228 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L13 compound treatment 7906800.0 -1220000.0 -1.05 7609600.0 -463000.0 -0.38 1.00884E7 468685.0 0.394107679885453 -0.5984 -0.5061 2141893 PK04_097229 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L14 compound treatment 8757880.0 -365000.0 -0.31 8172560.0 100000.0 0.08 9702160.0 82445.0 0.0693263229421811 -0.0934 -0.2811 2143417 PK04_097230 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L15 mock treatment 9616240.0 493000.0 0.42 8303480.0 231000.0 0.19 9892400.0 272685.0 0.229295268014903 0.4882 0.9401 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L16 mock treatment 9905120.0 782000.0 0.67 7903840.0 -169000.0 -0.14 9576720.0 -42995.0 -0.0361536206549709 0.2871 0.4169 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L17 compound treatment 9720160.0 597000.0 0.51 8102400.0 29900.0 0.02 9892080.0 272365.0 0.229026186526134 0.4434 0.787 2141152 PK04_097231 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L18 compound treatment 8905600.0 -217000.0 -0.19 8951000.0 878000.0 0.73 9961440.0 341725.0 0.287349599216651 0.4788 0.5945 2143325 PK04_097232 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L19 compound treatment 8860320.0 -262000.0 -0.23 7254080.0 -818000.0 -0.68 9047080.0 -572635.0 -0.481517119752512 -0.8004 -0.928 2141709 PK04_097233 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L20 compound treatment 8605160.0 -518000.0 -0.45 7028560.0 -1040000.0 -0.87 9071400.0 -548315.0 -0.461066926606126 -1.0234 -0.9498 2142773 PK04_097234 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L21 compound treatment 9084120.0 -38600.0 -0.03 7741440.0 -331000.0 -0.27 8638480.0 -981235.0 -0.825100545723465 -0.6541 -0.7517 2141174 PK04_097235 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L22 compound treatment 9180800.0 58000.0 0.05 7991840.0 -80700.0 -0.07 8948000.0 -671715.0 -0.56483147571238 -0.3359 -0.5883 2142985 PK04_097236 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L23 mock treatment 8477760.0 -645000.0 -0.56 8289600.0 217000.0 0.18 9530160.0 -89555.0 -0.0753049772707505 -0.26 -0.4418 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 L24 mock treatment 8292680.0 -830000.0 -0.71 7521280.0 -551000.0 -0.46 8963000.0 -656715.0 -0.552218280926368 -0.9953 -0.9834 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M01 compound treatment 8158080.0 -965000.0 -0.83 7316760.0 -756000.0 -0.63 8377320.0 -1242395.0 -1.04470467574445 -1.4445 -0.9797 2141838 PK04_097237 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M02 compound treatment 8636640.0 -486000.0 -0.42 7830920.0 -242000.0 -0.2 9393240.0 -226475.0 -0.190438219277463 -0.4672 -0.9317 2141189 PK04_097238 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M03 compound treatment 7214160.0 -1910000.0 -1.64 6347920.0 -1720000.0 -1.43 7595640.0 -2024075.0 -1.70200348243308 -2.757 -0.9973 2141724 PK04_097239 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M04 compound treatment 8556240.0 -567000.0 -0.49 7711360.0 -361000.0 -0.3 8541200.0 -1078515.0 -0.906901318309011 -0.9781 -0.9121 2141153 PK04_097240 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M05 compound treatment 8587240.0 -536000.0 -0.46 7795920.0 -277000.0 -0.23 9459480.0 -160235.0 -0.134738351102437 -0.4764 -0.8951 2141436 PK04_097241 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M06 compound treatment 8623880.0 -499000.0 -0.43 7503760.0 -569000.0 -0.47 9747560.0 127845.0 0.107502259161176 -0.4582 -0.7083 2141769 PK04_097242 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M07 compound treatment 8771040.0 -352000.0 -0.3 6345320.0 -1730000.0 -1.43 9307520.0 -312195.0 -0.262518423081257 -1.1536 -0.7754 2141771 PK04_097243 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M08 compound treatment 6460560.0 -2660000.0 -2.29 5707640.0 -2360000.0 -1.96 7393240.0 -2226475.0 -1.87219752407899 -3.5364 -0.9961 2141480 PK04_097244 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M09 mock treatment 8776680.0 -346000.0 -0.3 7826680.0 -246000.0 -0.2 9548480.0 -71235.0 -0.0599000620387685 -0.3243 -0.8862 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M10 mock treatment 9650040.0 527000.0 0.45 7935720.0 -137000.0 -0.11 1.008884E7 469125.0 0.394477666932509 0.4242 0.6933 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M11 compound treatment 8472560.0 -650000.0 -0.56 7499760.0 -573000.0 -0.48 9701560.0 81845.0 0.0688217951507406 -0.5577 -0.7563 2141571 PK04_097245 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M12 compound treatment 7003280.0 -2120000.0 -1.82 7875080.0 -197000.0 -0.16 5755240.0 -3864475.0 -3.24955839471145 -3.0238 -0.8107 2141879 PK04_097246 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M13 mock treatment 9960600.0 838000.0 0.72 8581440.0 509000.0 0.42 1.00954E7 475685.0 0.399993837452258 0.891 0.9618 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M14 mock treatment 9388120.0 265000.0 0.23 8291400.0 219000.0 0.18 1.011E7 490285.0 0.412270680377309 0.4747 0.9399 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M15 compound treatment 8638440.0 -484000.0 -0.42 7289600.0 -783000.0 -0.65 9687760.0 68045.0 0.0572176559476101 -0.5826 -0.7529 2141832 PK04_097247 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M16 compound treatment 9355840.0 233000.0 0.2 8249040.0 177000.0 0.15 9872080.0 252365.0 0.212208593478119 0.3229 0.9884 2141542 PK04_097248 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M17 compound treatment 8021440.0 -1100000.0 -0.95 6875800.0 -1200000.0 -0.99 8735200.0 -884515.0 -0.743770665743263 -1.5498 -0.9927 2141399 PK04_097249 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M18 compound treatment 9233800.0 111000.0 0.1 7818720.0 -254000.0 -0.21 9668080.0 48365.0 0.040669144388363 -0.0429 -0.1827 2141903 PK04_097250 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M19 compound treatment 1467800.0 -7650000.0 -6.59 692200.0 -7380000.0 -6.12 2042200.0 -7577515.0 -6.37177817926158 -11.0172 -0.9996 2141716 PK04_097251 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M20 compound treatment 9054920.0 -67800.0 -0.06 7582560.0 -490000.0 -0.41 9433120.0 -186595.0 -0.156903938739721 -0.359 -0.8166 2141203 PK04_097252 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M21 compound treatment 8603440.0 -519000.0 -0.45 8312120.0 240000.0 0.2 8930400.0 -689315.0 -0.579630957594633 -0.4779 -0.6301 2141110 PK04_097253 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M22 compound treatment 7442360.0 -1680000.0 -1.45 6549560.0 -1520000.0 -1.26 7752520.0 -1867195.0 -1.57008628256445 -2.4709 -0.9961 2141731 PK04_097254 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M23 compound treatment 8426760.0 -696000.0 -0.6 7655080.0 -417000.0 -0.35 8839960.0 -779755.0 -0.655680113357759 -0.9243 -0.9697 2141095 PK04_097255 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 M24 compound treatment 6896440.0 -2230000.0 -1.92 6432920.0 -1640000.0 -1.36 6955400.0 -2664315.0 -2.24036827108614 -3.185 -0.981 2141894 PK04_097256 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N01 compound treatment 8273400.0 -849000.0 -0.73 7289920.0 -783000.0 -0.65 1.113552E7 1515805.0 1.27460958150734 -0.061 -0.038 2141340 PK04_097257 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N02 compound treatment 8341000.0 -782000.0 -0.67 7771560.0 -301000.0 -0.25 8198760.0 -1420955.0 -1.19485214647713 -1.2224 -0.8771 2142089 PK04_097258 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N03 compound treatment 8597200.0 -526000.0 -0.45 8041680.0 -30800.0 -0.03 9434680.0 -185035.0 -0.155592166481976 -0.3657 -0.7635 2141511 PK04_097259 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N04 compound treatment 8166400.0 -956000.0 -0.82 8245600.0 173000.0 0.14 9671560.0 51845.0 0.0435954055787177 -0.3671 -0.4388 2144305 PK04_097260 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N05 compound treatment 7859400.0 -1260000.0 -1.09 7888760.0 -184000.0 -0.15 9201400.0 -418315.0 -0.351752571794026 -0.9188 -0.797 2141839 PK04_097261 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N06 compound treatment 8824880.0 -298000.0 -0.26 8267160.0 195000.0 0.16 9866720.0 247005.0 0.207701478541251 0.0651 0.1773 2142057 PK04_097262 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N07 compound treatment 8563120.0 -560000.0 -0.48 8062400.0 -10100.0 -0.01 9800280.0 180565.0 0.151833434435744 -0.1953 -0.3866 2141431 PK04_097263 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N08 compound treatment 8858280.0 -264000.0 -0.23 8071160.0 -1350.0 0.0 9952360.0 332645.0 0.279714411972853 0.0294 0.0816 2144369 PK04_097264 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N09 mock treatment 8660000.0 -463000.0 -0.4 7707040.0 -365000.0 -0.3 9734080.0 114365.0 0.0961672014468135 -0.3495 -0.6856 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N10 mock treatment 8888080.0 -235000.0 -0.2 8062960.0 -9550.0 -0.01 9989440.0 369725.0 0.310894229483873 0.0583 0.1572 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N11 compound treatment 8857440.0 -265000.0 -0.23 8014640.0 -57900.0 -0.05 9854320.0 234605.0 0.197274570851482 -0.0457 -0.1494 2141527 PK04_097265 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N12 compound treatment 8824160.0 -299000.0 -0.26 7934640.0 -138000.0 -0.11 9779720.0 160005.0 0.134544948782384 -0.1367 -0.4385 2144009 PK04_097266 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N13 mock treatment 9234680.0 112000.0 0.1 8423840.0 351000.0 0.29 9311520.0 -308195.0 -0.259154904471654 0.0743 0.1848 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N14 mock treatment 9141760.0 19000.0 0.02 8433120.0 361000.0 0.3 1.047724E7 857525.0 0.721075323924966 0.5985 0.7664 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N15 compound treatment 9121440.0 -1320.0 0.0 7893760.0 -179000.0 -0.15 9877840.0 258125.0 0.217052060275948 0.039 0.1485 2141907 PK04_097267 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N16 compound treatment 8725760.0 -397000.0 -0.34 7309000.0 -764000.0 -0.63 9278160.0 -341555.0 -0.287206649675743 -0.7288 -0.9405 2143157 PK04_097268 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N17 compound treatment 8829000.0 -294000.0 -0.25 7843160.0 -229000.0 -0.19 9405800.0 -213915.0 -0.17987677084331 -0.3597 -0.9882 2141544 PK04_097269 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N18 compound treatment 9169200.0 46400.0 0.04 7637240.0 -435000.0 -0.36 9379440.0 -240275.0 -0.202042358480594 -0.302 -0.7266 2144297 PK04_097270 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N19 compound treatment 9086560.0 -36200.0 -0.03 7036840.0 -1040000.0 -0.86 8991440.0 -628275.0 -0.528303663612091 -0.819 -0.8117 2141483 PK04_097271 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N20 compound treatment 8037480.0 -1090000.0 -0.93 7187160.0 -885000.0 -0.73 8758120.0 -861595.0 -0.724497704110237 -1.3816 -0.9928 2142217 PK04_097272 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N21 compound treatment 9026800.0 -96000.0 -0.08 8120640.0 48100.0 0.04 9613800.0 -5915.0 -0.00497380314395053 -0.0275 -0.2994 2141887 PK04_097273 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N22 compound treatment 8674640.0 -448000.0 -0.39 7878720.0 -194000.0 -0.16 8464520.0 -1155195.0 -0.971379970055102 -0.8763 -0.8287 2143065 PK04_097274 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N23 compound treatment 8369360.0 -753000.0 -0.65 7966240.0 -106000.0 -0.09 8906080.0 -713635.0 -0.60008115074102 -0.7717 -0.8692 2141817 PK04_097275 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 N24 compound treatment 7826000.0 -1300000.0 -1.12 7669600.0 -403000.0 -0.33 1.063924E7 1019525.0 0.85729782761389 -0.3424 -0.2367 2144333 PK04_097276 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O01 compound treatment 8072120.0 -1050000.0 -0.9 7262760.0 -810000.0 -0.67 7923120.0 -1696595.0 -1.42663221386488 -1.7336 -0.9537 2141166 PK04_097277 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O02 compound treatment 7265880.0 -1860000.0 -1.6 7190360.0 -882000.0 -0.73 8458760.0 -1160955.0 -0.97622343685293 -1.9088 -0.9494 2141900 PK04_097278 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O03 compound treatment 8954160.0 -169000.0 -0.15 8001720.0 -70800.0 -0.06 9707080.0 87365.0 0.0734634508319928 -0.0753 -0.4353 2141790 PK04_097279 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O04 compound treatment 5295480.0 -3830000.0 -3.29 5275960.0 -2800000.0 -2.32 5571000.0 -4048715.0 -3.40448206186976 -5.2067 -0.9871 2141883 PK04_097280 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O05 compound treatment 8488520.0 -634000.0 -0.55 8195240.0 123000.0 0.1 8944680.0 -675035.0 -0.567623196158351 -0.5841 -0.7356 2141427 PK04_097281 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O06 compound treatment 8668320.0 -454000.0 -0.39 8258160.0 186000.0 0.15 9351880.0 -267835.0 -0.225217001700759 -0.2669 -0.5597 2141093 PK04_097282 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O07 compound treatment 9109800.0 -13000.0 -0.01 8362200.0 290000.0 0.24 9518200.0 -101515.0 -0.0853618979134637 0.083 0.3252 2141812 PK04_097283 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O08 compound treatment 8929560.0 -193000.0 -0.17 8179280.0 107000.0 0.09 9268200.0 -351515.0 -0.295581811013655 -0.2155 -0.6149 2141430 PK04_097284 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O09 compound treatment 9120520.0 -2240.0 0.0 8393200.0 321000.0 0.27 9421320.0 -198395.0 -0.16682631863805 0.0562 0.1789 2141454 PK04_097285 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O10 compound treatment 9916400.0 794000.0 0.68 8199280.0 127000.0 0.11 9128440.0 -491275.0 -0.413103151233186 0.2166 0.269 2141529 PK04_097286 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O11 mock treatment 8944480.0 -178000.0 -0.15 8149960.0 77400.0 0.06 9701960.0 82245.0 0.0691581470117009 -0.0116 -0.0642 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O12 mock treatment 9444320.0 322000.0 0.28 8558200.0 486000.0 0.4 1.039376E7 774045.0 0.65087869054255 0.7682 0.9437 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O13 compound treatment 9250600.0 128000.0 0.11 7905440.0 -167000.0 -0.14 8994240.0 -625475.0 -0.525949200585369 -0.3202 -0.5769 2141368 PK04_097287 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O14 compound treatment 8849960.0 -273000.0 -0.23 7998600.0 -73900.0 -0.06 9710960.0 91245.0 0.0767260638833078 -0.1267 -0.4977 2141362 PK04_097288 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O15 compound treatment 9371360.0 249000.0 0.21 7651320.0 -421000.0 -0.35 9626600.0 6885.0 0.00578945640677927 -0.0749 -0.1827 2141460 PK04_097289 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O16 compound treatment 8063640.0 -1060000.0 -0.91 7576120.0 -496000.0 -0.41 8293120.0 -1326595.0 -1.11550674247659 -1.4081 -0.9398 2141860 PK04_097290 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O17 compound treatment 9250920.0 128000.0 0.11 8108280.0 35800.0 0.03 8929360.0 -690355.0 -0.58050547243313 -0.2543 -0.4299 2141175 PK04_097291 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O18 compound treatment 8698800.0 -424000.0 -0.36 7749840.0 -323000.0 -0.27 8880440.0 -739275.0 -0.621641305028576 -0.7241 -0.9417 2141486 PK04_097292 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O19 compound treatment 5518680.0 -3600000.0 -3.1 4566680.0 -3510000.0 -2.91 5425240.0 -4194475.0 -3.5270486800037 -5.5063 -0.9967 2141156 PK04_097293 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O20 compound treatment 8610720.0 -512000.0 -0.44 7718640.0 -354000.0 -0.29 9287520.0 -332195.0 -0.279336016129272 -0.5852 -0.9775 2141685 PK04_097294 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O21 compound treatment 9261280.0 139000.0 0.12 8178480.0 106000.0 0.09 9269600.0 -350115.0 -0.294404579500294 -0.0504 -0.1529 2141094 PK04_097295 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O22 compound treatment 7815880.0 -1310000.0 -1.12 7741520.0 -331000.0 -0.27 8328240.0 -1291475.0 -1.08597504908428 -1.4349 -0.9039 2141379 PK04_097296 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O23 compound treatment 638160.0 -8480000.0 -7.3 1456920.0 -6620000.0 -5.49 693800.0 -8925915.0 -7.50562030255878 -11.7178 -0.9911 2141397 PK04_097297 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 O24 compound treatment 7508000.0 -1610000.0 -1.39 7531760.0 -541000.0 -0.45 7988600.0 -1631115.0 -1.37157141422567 -1.8532 -0.925 2065842 PK04_097298 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P01 compound treatment 5177640.0 -3950000.0 -3.4 5448760.0 -2620000.0 -2.18 5761720.0 -3857995.0 -3.24410949456389 -5.0899 -0.9834 2141898 PK04_097299 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P02 compound treatment 7593440.0 -1530000.0 -1.32 7700480.0 -372000.0 -0.31 8608360.0 -1011355.0 -0.850427840853776 -1.4291 -0.8948 2143305 PK04_097300 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P03 compound treatment 8909160.0 -214000.0 -0.18 7291320.0 -781000.0 -0.65 8125440.0 -1494275.0 -1.25650544259115 -1.2057 -0.8457 2141555 PK04_097301 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P04 compound treatment 8402840.0 -720000.0 -0.62 7101160.0 -971000.0 -0.81 8719560.0 -900155.0 -0.756922023506811 -1.26 -0.9942 2144945 PK04_097302 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P05 compound treatment 302960.0 -8820000.0 -7.59 293120.0 -7780000.0 -6.45 307960.0 -9311755.0 -7.83006530764109 -12.6291 -0.9966 2141923 PK04_097303 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P06 compound treatment 7878120.0 -1240000.0 -1.07 7592320.0 -480000.0 -0.4 8849520.0 -770195.0 -0.647641303880807 -1.2224 -0.9305 2144433 PK04_097304 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P07 compound treatment 7492080.0 -1630000.0 -1.4 6936400.0 -1140000.0 -0.94 9669280.0 49565.0 0.0416781999712439 -1.3304 -0.7867 2141482 PK04_097305 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P08 compound treatment 1.008108E7 958000.0 0.82 7786880.0 -286000.0 -0.24 9454960.0 -164755.0 -0.138539127131288 0.2594 0.2984 2143929 PK04_097306 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P09 compound treatment 1.02168E7 1090000.0 0.94 7497440.0 -575000.0 -0.48 1.320752E7 3587805.0 3.01691222128173 2.01 0.6289 2141698 PK04_097307 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P10 compound treatment 1.110336E7 1980000.0 1.7 7025120.0 -1050000.0 -0.87 8760080.0 -859635.0 -0.722849579991532 0.0652 0.0319 2142653 PK04_097308 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P11 mock treatment 8807720.0 -315000.0 -0.27 8191600.0 119000.0 0.1 8941280.0 -678435.0 -0.570482186976513 -0.4289 -0.6708 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P12 mock treatment 8151640.0 -971000.0 -0.84 7791960.0 -281000.0 -0.23 9077200.0 -542515.0 -0.456189824622201 -0.8803 -0.8981 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P13 compound treatment 5997040.0 -3130000.0 -2.69 4645440.0 -3430000.0 -2.84 5633040.0 -3986675.0 -3.35231388823482 -5.13 -0.9955 2141449 PK04_097309 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P14 compound treatment 8704520.0 -418000.0 -0.36 7951160.0 -121000.0 -0.1 8426920.0 -1192795.0 -1.00299704498537 -0.845 -0.7895 2144933 PK04_097310 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P15 compound treatment 7991040.0 -1130000.0 -0.97 7766680.0 -306000.0 -0.25 9190520.0 -429195.0 -0.360901342412146 -0.9172 -0.8578 2141416 PK04_097311 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P16 compound treatment 8188480.0 -934000.0 -0.8 7455960.0 -617000.0 -0.51 8676080.0 -943635.0 -0.793483470793196 -1.2177 -0.9819 2144445 PK04_097312 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P17 compound treatment 8357480.0 -765000.0 -0.66 7667480.0 -405000.0 -0.34 9528600.0 -91115.0 -0.0766167495284957 -0.6185 -0.832 2141453 PK04_097313 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P18 compound treatment 4641360.0 -4480000.0 -3.86 4286200.0 -3790000.0 -3.14 5125200.0 -4494515.0 -3.77934621091002 -6.2222 -0.996 2142745 PK04_097314 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P19 compound treatment 8364480.0 -758000.0 -0.65 7813480.0 -259000.0 -0.21 8986520.0 -633195.0 -0.532440791501902 -0.8083 -0.9298 2141541 PK04_097315 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P20 compound treatment 7474880.0 -1650000.0 -1.42 7286440.0 -786000.0 -0.65 8498200.0 -1121515.0 -0.943059143362244 -1.7398 -0.954 2142193 PK04_097316 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P21 compound treatment 8557640.0 -565000.0 -0.49 7950440.0 -122000.0 -0.1 9662760.0 43045.0 0.0361956646375909 -0.3184 -0.6392 2141134 PK04_097317 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P22 compound treatment 7748320.0 -1370000.0 -1.18 7777880.0 -295000.0 -0.24 8575760.0 -1043955.0 -0.877840517522041 -1.3309 -0.8913 2142729 PK04_097318 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P23 compound treatment 7982200.0 -1140000.0 -0.98 7393720.0 -679000.0 -0.56 8289920.0 -1329795.0 -1.11819755736428 -1.5374 -0.9664 2141121 PK04_097319 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2097 P24 compound treatment 6790000.0 -2330000.0 -2.01 6473600.0 -1600000.0 -1.33 7798720.0 -1820995.0 -1.53123764262353 -2.809 -0.9849 2144273 PK04_097320 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A01 compound treatment 6162360.0 -2690000.0 -2.32 6690840.0 -3110000.0 -2.58 6602360.0 -3463968.3870968 -2.9127805332692 -4.5099 -0.9957 2141696 PK04_098001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A02 compound treatment 6030240.0 -2830000.0 -2.43 6985120.0 -2820000.0 -2.34 7302600.0 -2763728.3870968 -2.32396296547208 -4.0947 -0.9998 2144133 PK04_098002 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A03 compound treatment 6516720.0 -2340000.0 -2.01 7557960.0 -2240000.0 -1.86 7865840.0 -2200488.3870968 -1.85034591005388 -3.3051 -0.9992 2141089 PK04_098003 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A04 compound treatment 6721720.0 -2130000.0 -1.84 7902760.0 -1900000.0 -1.58 7957120.0 -2109208.3870968 -1.77359041538274 -2.9938 -0.9979 2142093 PK04_098004 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A05 compound treatment 3976440.0 -4880000.0 -4.2 5631840.0 -4170000.0 -3.46 5756640.0 -4309688.3870968 -3.62392927289757 -6.5139 -0.9965 2141744 PK04_098005 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A06 compound treatment 6752400.0 -2100000.0 -1.81 7669240.0 -2130000.0 -1.77 7930320.0 -2136008.3870968 -1.79612599006708 -3.1034 -1.0 2143237 PK04_098006 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A07 compound treatment 6793520.0 -2060000.0 -1.77 8215600.0 -1590000.0 -1.32 7947560.0 -2118768.3870968 -1.78162922485969 -2.8129 -0.9911 2141337 PK04_098007 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A08 compound treatment 7314000.0 -1540000.0 -1.33 7740680.0 -2060000.0 -1.71 8027480.0 -2038848.3870968 -1.71442612303982 -2.743 -0.9935 2144129 PK04_098008 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A09 compound treatment 6988200.0 -1870000.0 -1.61 8106320.0 -1700000.0 -1.41 7863280.0 -2203048.3870968 -1.85249856196402 -2.8095 -0.9937 2141791 PK04_098009 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A10 compound treatment 7050680.0 -1800000.0 -1.55 7573040.0 -2230000.0 -1.85 8430040.0 -1636288.3870968 -1.37592161016937 -2.7587 -0.9926 2144193 PK04_098010 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A11 compound treatment 4311320.0 -4540000.0 -3.91 4708160.0 -5090000.0 -4.23 5087000.0 -4979328.3870968 -4.18701592333122 -7.115 -0.9994 2141133 PK04_098011 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A12 compound treatment 7678000.0 -1180000.0 -1.01 8085440.0 -1720000.0 -1.42 7575480.0 -2490848.3870968 -2.09450372592496 -2.6164 -0.9591 2143993 PK04_098012 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A13 mock treatment 7181160.0 -1670000.0 -1.44 7539520.0 -2260000.0 -1.88 7852720.0 -2213608.3870968 -1.86137825109338 -2.9902 -0.9932 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A14 mock treatment 6981640.0 -1870000.0 -1.61 8090760.0 -1710000.0 -1.42 8703080.0 -1363248.3870968 -1.14632782987786 -2.4125 -0.9907 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A15 compound treatment 7611200.0 -1240000.0 -1.07 8215720.0 -1590000.0 -1.32 8240200.0 -1826128.3870968 -1.53555420338113 -2.2645 -0.9896 2141695 PK04_098013 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A16 compound treatment 7319680.0 -1540000.0 -1.32 8061200.0 -1740000.0 -1.44 8127080.0 -1939248.3870968 -1.6306745096607 -2.5383 -0.9963 2144913 PK04_098014 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A17 compound treatment 7121080.0 -1730000.0 -1.49 7293920.0 -2510000.0 -2.08 7764960.0 -2301368.3870968 -1.93517384938807 -3.1803 -0.9908 2141801 PK04_098015 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A18 compound treatment 6903160.0 -1950000.0 -1.68 8078000.0 -1720000.0 -1.43 7403800.0 -2662528.3870968 -2.23886594464913 -3.0883 -0.9825 2142117 PK04_098016 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A19 compound treatment 7256240.0 -1600000.0 -1.38 7289920.0 -2510000.0 -2.08 7785960.0 -2280368.3870968 -1.91751537668765 -3.1048 -0.9861 2141835 PK04_098017 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A20 compound treatment 6666560.0 -2190000.0 -1.88 7593640.0 -2210000.0 -1.83 8277640.0 -1788688.3870968 -1.50407166919524 -3.0137 -0.9954 2144205 PK04_098018 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A21 compound treatment 2477400.0 -6380000.0 -5.49 3229080.0 -6570000.0 -5.45 2798440.0 -7267888.3870968 -6.11141946062951 -9.8457 -0.9986 2141920 PK04_098019 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A22 compound treatment 6597680.0 -2260000.0 -1.94 7689960.0 -2110000.0 -1.75 7081760.0 -2984568.3870968 -2.50966282790827 -3.5823 -0.9881 2141945 PK04_098020 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A23 compound treatment 6812920.0 -2040000.0 -1.76 9004360.0 -798000.0 -0.66 6971720.0 -3094608.3870968 -2.60219322485845 -2.8993 -0.9034 2141111 PK04_098021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 A24 compound treatment 5335600.0 -3520000.0 -3.03 5688320.0 -4110000.0 -3.41 6204760.0 -3861568.3870968 -3.24711428306374 -5.5939 -0.9988 2143385 PK04_098022 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B01 compound treatment 3280600.0 -5570000.0 -4.8 4584000.0 -5220000.0 -4.33 4141120.0 -5925208.3870968 -4.98238716894406 -8.1458 -0.9983 2142845 PK04_098023 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B02 compound treatment 8149560.0 -706000.0 -0.61 8833280.0 -969000.0 -0.8 9291440.0 -774888.3870968 -0.651587877591347 -1.1909 -0.9926 2143009 PK04_098024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B03 compound treatment 7909880.0 -945000.0 -0.81 9393760.0 -408000.0 -0.34 9574200.0 -492128.3870968 -0.413820747078506 -0.9042 -0.9287 2144209 PK04_098025 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B04 compound treatment 7633440.0 -1220000.0 -1.05 9184320.0 -618000.0 -0.51 9015280.0 -1051048.3870968 -0.883805202398342 -1.4133 -0.9639 2142037 PK04_098026 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B05 compound treatment 8116480.0 -739000.0 -0.64 9037840.0 -764000.0 -0.63 9392880.0 -673448.3870968 -0.566289045651813 -1.0601 -0.9986 2144313 PK04_098027 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B06 compound treatment 7630720.0 -1220000.0 -1.05 8395120.0 -1410000.0 -1.17 8719680.0 -1346648.3870968 -1.13236922764801 -1.9361 -0.9991 2143245 PK04_098028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B07 compound treatment 8504560.0 -351000.0 -0.3 8988200.0 -814000.0 -0.68 9581080.0 -485248.3870968 -0.408035495069989 -0.7997 -0.9467 2144661 PK04_098029 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B08 compound treatment 8287480.0 -568000.0 -0.49 9240600.0 -561000.0 -0.47 9041880.0 -1024448.3870968 -0.861437803644482 -1.0484 -0.9579 2143409 PK04_098030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B09 compound treatment 7805480.0 -1050000.0 -0.9 8356960.0 -1450000.0 -1.2 9469640.0 -596688.3870968 -0.50174312353353 -1.5035 -0.9499 2144745 PK04_098031 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B10 compound treatment 8068080.0 -787000.0 -0.68 9771440.0 -30600.0 -0.03 9892280.0 -174048.3870968 -0.146353747242871 -0.4903 -0.7069 2143049 PK04_098032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B11 compound treatment 7764960.0 -1090000.0 -0.94 9255520.0 -547000.0 -0.45 9542360.0 -523968.3870968 -0.440594355210947 -1.0579 -0.935 2143257 PK04_098033 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B12 compound treatment 7522240.0 -1330000.0 -1.15 7386880.0 -2420000.0 -2.0 8979040.0 -1087288.3870968 -0.914278681001346 -2.347 -0.9451 2141502 PK04_098034 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B13 mock treatment 8844720.0 -10600.0 -0.01 9744080.0 -58000.0 -0.05 9714560.0 -351768.3870968 -0.295794879067535 -0.2038 -0.6797 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B14 mock treatment 8565200.0 -290000.0 -0.25 8473160.0 -1330000.0 -1.1 8741480.0 -1324848.3870968 -1.11403805122567 -1.4238 -0.8971 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B15 compound treatment 7845360.0 -1010000.0 -0.87 8322600.0 -1480000.0 -1.23 8856760.0 -1209568.3870968 -1.01710144489691 -1.7976 -0.9901 2142113 PK04_098035 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B16 compound treatment 8127240.0 -728000.0 -0.63 9657320.0 -145000.0 -0.12 9773040.0 -293288.3870968 -0.246620236995138 -0.5735 -0.8384 2141859 PK04_098036 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B17 compound treatment 6766600.0 -2090000.0 -1.8 8285440.0 -1520000.0 -1.26 8601480.0 -1464848.3870968 -1.23176120256178 -2.4754 -0.9838 2144033 PK04_098037 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B18 compound treatment 8989720.0 134000.0 0.12 9246840.0 -555000.0 -0.46 9528880.0 -537448.3870968 -0.451929412925309 -0.46 -0.7017 2141540 PK04_098038 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B19 compound treatment 7344000.0 -1510000.0 -1.3 9082400.0 -720000.0 -0.6 8867200.0 -1199128.3870968 -1.00832266132585 -1.6778 -0.9584 2144437 PK04_098039 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B20 compound treatment 3869160.0 -4990000.0 -4.29 4427520.0 -5370000.0 -4.46 4223320.0 -5843008.3870968 -4.91326686151671 -7.8884 -0.9983 2144725 PK04_098040 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B21 compound treatment 7629720.0 -1230000.0 -1.05 8401280.0 -1400000.0 -1.16 9027840.0 -1038488.3870968 -0.873243753964188 -1.784 -0.9934 2143413 PK04_098041 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B22 compound treatment 8452760.0 -403000.0 -0.35 8223840.0 -1580000.0 -1.31 8969120.0 -1097208.3870968 -0.922620207153161 -1.4886 -0.9084 2141509 PK04_098042 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B23 compound treatment 7990000.0 -865000.0 -0.74 8170400.0 -1630000.0 -1.35 9224960.0 -841368.3870968 -0.70748955688295 -1.6199 -0.9533 2142009 PK04_098043 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 B24 compound treatment 6827680.0 -2030000.0 -1.75 8090480.0 -1710000.0 -1.42 8489480.0 -1576848.3870968 -1.32593972363066 -2.5928 -0.9929 2141342 PK04_098044 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C01 compound treatment 7632200.0 -1220000.0 -1.05 8371680.0 -1430000.0 -1.19 8499360.0 -1566968.3870968 -1.31763183266494 -2.0536 -0.9959 2141145 PK04_098045 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C02 compound treatment 8049800.0 -805000.0 -0.69 9612160.0 -190000.0 -0.16 1.001584E7 -50488.3870967999 -0.0424546573922324 -0.5157 -0.7241 2143097 PK04_098046 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C03 compound treatment 7679960.0 -1180000.0 -1.01 9185720.0 -616000.0 -0.51 9609160.0 -457168.3870968 -0.384423594430576 -1.1012 -0.9201 2141834 PK04_098047 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C04 compound treatment 4649280.0 -4210000.0 -3.62 5274640.0 -4530000.0 -3.76 5696880.0 -4369448.3870968 -3.67418024092504 -6.3796 -0.9999 2142605 PK04_098048 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C05 compound treatment 7026760.0 -1830000.0 -1.57 9110480.0 -692000.0 -0.57 8947560.0 -1118768.3870968 -0.940749572458922 -1.783 -0.9281 2141398 PK04_098049 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C06 compound treatment 8750280.0 -105000.0 -0.09 1.032776E7 526000.0 0.44 1.054056E7 474231.6129032 0.398771713815497 0.4298 0.719 2143013 PK04_098050 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C07 compound treatment 8616400.0 -239000.0 -0.21 1.007536E7 273000.0 0.23 1.03036E7 237271.6129032 0.199516871382612 0.1274 0.3487 2141793 PK04_098051 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C08 compound treatment 8386240.0 -469000.0 -0.4 9861560.0 59500.0 0.05 1.00756E7 9271.61290320009 0.00779631063523734 -0.2001 -0.4919 2143277 PK04_098052 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C09 compound treatment 5997920.0 -2860000.0 -2.46 7806720.0 -2000000.0 -1.66 7370800.0 -2695528.3870968 -2.26661497317835 -3.6841 -0.9873 2141681 PK04_098053 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C10 compound treatment 3683680.0 -5170000.0 -4.45 4383520.0 -5420000.0 -4.5 4746400.0 -5319928.3870968 -4.47341953293892 -7.7477 -1.0 2144125 PK04_098054 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C11 mock treatment 8299920.0 -555000.0 -0.48 9897080.0 95000.0 0.08 1.0104E7 37671.6129032001 0.0316772927634191 -0.2122 -0.437 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C12 mock treatment 8995880.0 141000.0 0.12 9558040.0 -244000.0 -0.2 1.026612E7 199791.6129032 0.168000702010631 0.05 0.1726 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C13 compound treatment 6032680.0 -2820000.0 -2.43 8336560.0 -1470000.0 -1.22 8864080.0 -1202248.3870968 -1.01094620584134 -2.6881 -0.9274 2141376 PK04_098055 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C14 compound treatment 8300320.0 -555000.0 -0.48 9582360.0 -220000.0 -0.18 1.037828E7 311951.6129032 0.262313763823901 -0.2295 -0.3995 2143897 PK04_098056 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C15 mock treatment 8075080.0 -780000.0 -0.67 9372280.0 -430000.0 -0.36 9644440.0 -421888.3870968 -0.354757360293877 -0.7983 -0.9516 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C16 mock treatment 8176240.0 -679000.0 -0.58 9200600.0 -601000.0 -0.5 1.031016E7 243831.6129032 0.205033041902361 -0.5071 -0.6376 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C17 compound treatment 8873800.0 18500.0 0.02 1.000924E7 207000.0 0.17 1.021052E7 144191.6129032 0.121247793337149 0.1784 0.8459 2141461 PK04_098057 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C18 compound treatment 8138160.0 -717000.0 -0.62 9422120.0 -380000.0 -0.32 8889600.0 -1176728.3870968 -0.98948695711207 -1.1096 -0.9185 2143145 PK04_098058 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C19 compound treatment 8581200.0 -274000.0 -0.24 9535680.0 -266000.0 -0.22 1.021588E7 149551.6129032 0.125754908274017 -0.1912 -0.5512 2141551 PK04_098059 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C20 compound treatment 8233920.0 -621000.0 -0.53 9672160.0 -130000.0 -0.11 1.002692E7 -39408.3870967999 -0.0331377108436319 -0.3901 -0.7138 2144941 PK04_098060 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C21 compound treatment 6391160.0 -2460000.0 -2.12 7039960.0 -2760000.0 -2.29 7757040.0 -2309288.3870968 -1.94183361623508 -3.6684 -0.9977 2141535 PK04_098061 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C22 compound treatment 7322640.0 -1530000.0 -1.32 8763480.0 -1040000.0 -0.86 8415800.0 -1650528.3870968 -1.38789573641955 -2.0603 -0.9813 2142185 PK04_098062 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C23 compound treatment 8724760.0 -131000.0 -0.11 9264320.0 -538000.0 -0.45 9221440.0 -844888.3870968 -0.7104494532594 -0.7326 -0.8656 2141425 PK04_098063 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 C24 compound treatment 7421080.0 -1430000.0 -1.23 8128720.0 -1670000.0 -1.39 8559720.0 -1506608.3870968 -1.26687633684603 -2.2455 -0.9987 2144353 PK04_098064 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D01 compound treatment 8374560.0 -481000.0 -0.41 9621640.0 -180000.0 -0.15 8987200.0 -1079128.3870968 -0.907417103037755 -0.8492 -0.8421 2143317 PK04_098065 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D02 compound treatment 8213680.0 -642000.0 -0.55 9714680.0 -87400.0 -0.07 9710840.0 -355488.3870968 -0.298922951374466 -0.5332 -0.8436 2144805 PK04_098066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D03 compound treatment 8946800.0 91500.0 0.08 1.023688E7 435000.0 0.36 1.07022E7 635871.6129032 0.534691500829557 0.5624 0.8656 2142937 PK04_098067 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D04 compound treatment 9527360.0 672000.0 0.58 9740200.0 -61900.0 -0.05 1.009428E7 27951.6129032001 0.0235039425420836 0.3179 0.547 2141997 PK04_098068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D05 compound treatment 8024000.0 -831000.0 -0.72 9586840.0 -215000.0 -0.18 1.00624E7 -3928.38709679991 -0.00330330077645276 -0.518 -0.7025 2144781 PK04_098069 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D06 compound treatment 4991600.0 -3860000.0 -3.33 6412320.0 -3390000.0 -2.81 5903600.0 -4162728.3870968 -3.50035359918075 -5.5643 -0.9959 2144025 PK04_098070 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D07 compound treatment 8455080.0 -400000.0 -0.34 9739200.0 -62900.0 -0.05 1.010772E7 41391.6129032001 0.0348053650703499 -0.2089 -0.5966 2144817 PK04_098071 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D08 compound treatment 9078760.0 223000.0 0.19 9895080.0 93000.0 0.08 1.077468E7 708351.6129032 0.595638458035564 0.4995 0.792 2144197 PK04_098072 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D09 compound treatment 7965000.0 -890000.0 -0.77 9537360.0 -265000.0 -0.22 9311960.0 -754368.3870968 -0.634333027124083 -0.9354 -0.9182 2144761 PK04_098073 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D10 compound treatment 5742240.0 -3110000.0 -2.68 7093400.0 -2710000.0 -2.25 7361400.0 -2704928.3870968 -2.27451924191092 -4.1574 -0.9966 2142125 PK04_098074 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D11 mock treatment 9331040.0 476000.0 0.41 9841600.0 39500.0 0.03 1.100608E7 939751.6129032 0.790218009601101 0.7116 0.799 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D12 mock treatment 9727120.0 872000.0 0.75 9918800.0 117000.0 0.1 1.078536E7 719031.6129032 0.604619052723204 0.8382 0.8655 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D13 compound treatment 8572120.0 -283000.0 -0.24 9043440.0 -759000.0 -0.63 9365520.0 -700808.3870968 -0.589295512941498 -0.8443 -0.9423 2143225 PK04_098075 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D14 compound treatment 9602520.0 747000.0 0.64 1.011568E7 314000.0 0.26 1.12716E7 1205271.6129032 1.01348837490655 1.1066 0.901 2144233 PK04_098076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D15 mock treatment 9658760.0 803000.0 0.69 9743600.0 -58500.0 -0.05 1.010032E7 33991.6129032001 0.0285828556425843 0.3877 0.5589 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D16 mock treatment 8835080.0 -20200.0 -0.02 1.047752E7 675000.0 0.56 1.044904E7 382711.6129032 0.321814408027779 0.4993 0.7724 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D17 compound treatment 9137920.0 283000.0 0.24 9964200.0 162000.0 0.13 1.023104E7 164711.6129032 0.138502643804412 0.2981 0.9598 2143045 PK04_098077 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D18 compound treatment 8747040.0 -108000.0 -0.09 1.01532E7 351000.0 0.29 1.085672E7 790391.6129032 0.664624224718523 0.4981 0.6808 2142013 PK04_098078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D19 compound treatment 8457520.0 -398000.0 -0.34 9991200.0 189000.0 0.16 9259240.0 -807088.3870968 -0.678664202398651 -0.4989 -0.6428 2142213 PK04_098079 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D20 compound treatment 8595040.0 -260000.0 -0.22 9586800.0 -215000.0 -0.18 1.050788E7 441551.6129032 0.37129176677504 -0.018 -0.0385 2141447 PK04_098080 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D21 compound treatment 8670640.0 -185000.0 -0.16 9448840.0 -353000.0 -0.29 9510600.0 -555728.3870968 -0.467300692971195 -0.5307 -0.9246 2143393 PK04_098081 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D22 compound treatment 9055520.0 200000.0 0.17 9390520.0 -412000.0 -0.34 1.009608E7 29751.6129032001 0.025017525916405 -0.0832 -0.217 2065844 PK04_098082 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D23 compound treatment 7699400.0 -1160000.0 -0.99 9000320.0 -802000.0 -0.67 9425560.0 -640768.3870968 -0.538809098611356 -1.2694 -0.9673 2144185 PK04_098083 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 D24 compound treatment 7830080.0 -1030000.0 -0.88 8633440.0 -1170000.0 -0.97 8524480.0 -1541848.3870968 -1.29650893579664 -1.8177 -0.9859 2141197 PK04_098084 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E01 mock treatment 8253480.0 -602000.0 -0.52 8967040.0 -835000.0 -0.69 9699200.0 -367128.3870968 -0.308710790528411 -0.8772 -0.9552 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E02 mock treatment 8203480.0 -652000.0 -0.56 1.017256E7 370000.0 0.31 9821880.0 -244448.3870968 -0.205551674771885 -0.2651 -0.3946 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E03 compound treatment 8218840.0 -636000.0 -0.55 9734080.0 -68000.0 -0.06 9775360.0 -290968.3870968 -0.244669396201568 -0.4901 -0.8133 2141526 PK04_098085 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E04 compound treatment 9000280.0 145000.0 0.12 1.024544E7 443000.0 0.37 1.034512E7 278791.6129032 0.234430194550292 0.4198 0.9252 2142637 PK04_098086 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E05 compound treatment 8423280.0 -432000.0 -0.37 9739760.0 -62300.0 -0.05 9845640.0 -220688.3870968 -0.185572374230843 -0.3516 -0.8398 2141181 PK04_098087 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E06 compound treatment 7981600.0 -874000.0 -0.75 9574680.0 -227000.0 -0.19 1.014648E7 80151.6129032001 0.0673978603974036 -0.5041 -0.6478 2142777 PK04_098088 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E07 compound treatment 8664080.0 -191000.0 -0.16 1.01774E7 375000.0 0.31 1.078704E7 720711.6129032 0.606031730539238 0.4347 0.6201 2141090 PK04_098089 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E08 compound treatment 8199920.0 -655000.0 -0.56 9468280.0 -334000.0 -0.28 9146280.0 -920048.3870968 -0.773649967933842 -0.9322 -0.9353 2144801 PK04_098090 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E09 mock treatment 9044680.0 189000.0 0.16 1.06476E7 846000.0 0.7 1.047568E7 409351.6129032 0.344215441967735 0.6978 0.8743 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E10 mock treatment 8935320.0 80000.0 0.07 1.034548E7 543000.0 0.45 1.05408E7 474471.6129032 0.398973524932073 0.5304 0.8753 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E11 compound treatment 8469000.0 -386000.0 -0.33 9997160.0 195000.0 0.16 1.035844E7 292111.6129032 0.24563071152027 0.0433 0.0976 2141328 PK04_098091 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E12 compound treatment 6059120.0 -2800000.0 -2.41 8094480.0 -1710000.0 -1.42 8635960.0 -1430368.3870968 -1.202767672147 -2.9017 -0.9543 2144117 PK04_098092 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E13 compound treatment 7943000.0 -912000.0 -0.79 9378880.0 -423000.0 -0.35 8828920.0 -1237408.3870968 -1.04051153441975 -1.2567 -0.9309 2141750 PK04_098093 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E14 compound treatment 9051160.0 196000.0 0.17 9982920.0 181000.0 0.15 1.053532E7 468991.6129032 0.394365504436917 0.4116 0.906 2142133 PK04_098094 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E15 compound treatment 8194840.0 -660000.0 -0.57 9578040.0 -224000.0 -0.19 1.018816E7 121831.6129032 0.102445724309467 -0.3763 -0.6202 2141837 PK04_098095 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E16 compound treatment 8903400.0 48100.0 0.04 1.001112E7 209000.0 0.17 1.0237E7 170671.6129032 0.143514286532721 0.2069 0.9039 2143333 PK04_098096 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E17 mock treatment 8722040.0 -133000.0 -0.11 1.01824E7 380000.0 0.32 1.058192E7 515591.6129032 0.433550496238793 0.3663 0.668 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E18 mock treatment 8895560.0 40300.0 0.03 9531040.0 -271000.0 -0.22 1.013544E7 69111.6129032001 0.0581145490348991 -0.0762 -0.3247 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E19 compound treatment 3422800.0 -5430000.0 -4.68 4081120.0 -5720000.0 -4.75 4297760.0 -5768568.3870968 -4.850671780192 -8.2399 -0.9999 2141392 PK04_098097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E20 compound treatment 8316200.0 -539000.0 -0.46 1.065924E7 857000.0 0.71 1.054372E7 477391.6129032 0.401428893517084 0.3744 0.3987 2144457 PK04_098098 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E21 compound treatment 8622360.0 -233000.0 -0.2 9474240.0 -328000.0 -0.27 9986520.0 -79808.3870967999 -0.0671092488006228 -0.3115 -0.9043 2141783 PK04_098099 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E22 compound treatment 8286880.0 -568000.0 -0.49 9261200.0 -541000.0 -0.45 9596800.0 -469528.3870968 -0.394816866934249 -0.7694 -0.9962 2142073 PK04_098100 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E23 compound treatment 7541120.0 -1310000.0 -1.13 8730840.0 -1070000.0 -0.89 9200880.0 -865448.3870968 -0.72773793891276 -1.5862 -0.984 2141929 PK04_098101 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 E24 compound treatment 7971160.0 -884000.0 -0.76 8649720.0 -1150000.0 -0.96 9398160.0 -668168.3870968 -0.561849201087137 -1.3156 -0.9783 2141993 PK04_098102 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F01 mock treatment 7871320.0 -984000.0 -0.85 8807200.0 -995000.0 -0.83 8799720.0 -1266608.3870968 -1.06506522026985 -1.5803 -0.993 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F02 mock treatment 8632240.0 -223000.0 -0.19 9659520.0 -143000.0 -0.12 9844600.0 -221728.3870968 -0.186446889069339 -0.2867 -0.9801 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F03 compound treatment 7382640.0 -1470000.0 -1.27 8884560.0 -918000.0 -0.76 8830160.0 -1236168.3870968 -1.03946884365077 -1.7713 -0.9801 2142917 PK04_098103 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F04 compound treatment 8644960.0 -210000.0 -0.18 1.047E7 668000.0 0.55 1.030716E7 240831.6129032 0.202510402945159 0.3323 0.5385 2142953 PK04_098104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F05 compound treatment 6555720.0 -2300000.0 -1.98 8624120.0 -1180000.0 -0.98 8510600.0 -1555728.3870968 -1.30818034537196 -2.4621 -0.9596 2144897 PK04_098105 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F06 compound treatment 8731120.0 -124000.0 -0.11 1.028388E7 482000.0 0.4 1.003236E7 -33968.3870967999 -0.0285633255345717 0.1526 0.3679 2144329 PK04_098106 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F07 compound treatment 7104080.0 -1750000.0 -1.51 8204240.0 -1600000.0 -1.33 8519280.0 -1547048.3870968 -1.30088150998912 -2.3865 -0.9978 2144721 PK04_098107 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F08 compound treatment 9052000.0 197000.0 0.17 9865440.0 63400.0 0.05 9507160.0 -559168.3870968 -0.470193318975454 -0.1434 -0.2853 2143969 PK04_098108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F09 mock treatment 9295440.0 440000.0 0.38 9866920.0 64900.0 0.05 1.022996E7 163631.6129032 0.137594493779819 0.3292 0.8097 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F10 mock treatment 8944080.0 88800.0 0.08 1.060116E7 799000.0 0.66 1.088384E7 817511.6129032 0.687428880891632 0.8237 0.8598 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F11 compound treatment 8559720.0 -296000.0 -0.25 1.041144E7 609000.0 0.51 1.001712E7 -49208.3870967999 -0.0413783314371594 0.1211 0.2134 2141973 PK04_098109 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F12 compound treatment 9174760.0 319000.0 0.27 1.003428E7 232000.0 0.19 1.073448E7 668151.6129032 0.561835096009053 0.5943 0.9081 2141515 PK04_098110 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F13 compound treatment 9228280.0 373000.0 0.32 1.022232E7 420000.0 0.35 9407320.0 -659008.3870968 -0.554146743471146 0.0667 0.0915 2144053 PK04_098111 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F14 compound treatment 8440240.0 -415000.0 -0.36 9829960.0 27900.0 0.02 1.025616E7 189831.6129032 0.15962554067272 -0.1007 -0.257 2143249 PK04_098112 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F15 compound treatment 4445720.0 -4410000.0 -3.8 5521440.0 -4280000.0 -3.55 5469920.0 -4596408.3870968 -3.86502628683392 -6.4728 -0.9994 2144873 PK04_098113 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F16 compound treatment 8722720.0 -133000.0 -0.11 9939520.0 137000.0 0.11 9996920.0 -69408.3870967999 -0.0583641004156549 -0.0337 -0.1966 2141199 PK04_098114 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F17 mock treatment 9702920.0 848000.0 0.73 1.024312E7 441000.0 0.37 1.087088E7 804551.6129032 0.676531080596518 1.023 0.965 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F18 mock treatment 9122760.0 267000.0 0.23 9804880.0 2810.0 0.0 1.065696E7 590631.6129032 0.496650105354946 0.421 0.7691 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F19 compound treatment 5550720.0 -3300000.0 -2.84 6054520.0 -3750000.0 -3.11 7260080.0 -2806248.3870968 -2.35971716829216 -4.7993 -0.9938 2142825 PK04_098115 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F20 compound treatment 8813440.0 -41800.0 -0.04 9597160.0 -205000.0 -0.17 1.007712E7 10791.6129032001 0.0090744477068865 -0.1137 -0.6534 2144217 PK04_098116 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F21 compound treatment 7681440.0 -1170000.0 -1.01 8947640.0 -854000.0 -0.71 9214040.0 -852288.3870968 -0.716671962687166 -1.4063 -0.9854 2144057 PK04_098117 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F22 compound treatment 8699240.0 -156000.0 -0.13 9554240.0 -248000.0 -0.21 1.056316E7 496831.6129032 0.417775593959754 0.045 0.0928 2141689 PK04_098118 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F23 compound treatment 7115280.0 -1740000.0 -1.5 7671080.0 -2130000.0 -1.77 7436440.0 -2629888.3870968 -2.21141963279477 -3.162 -0.9873 2144037 PK04_098119 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 F24 compound treatment 8148560.0 -707000.0 -0.61 8878880.0 -923000.0 -0.77 8637120.0 -1429208.3870968 -1.20179225175022 -1.4872 -0.9598 2141464 PK04_098120 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G01 compound treatment 4349000.0 -4510000.0 -3.88 5622800.0 -4180000.0 -3.47 5111360.0 -4954968.3870968 -4.16653209499874 -6.6463 -0.9972 2141573 PK04_098121 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G02 compound treatment 6998080.0 -1860000.0 -1.6 9129760.0 -672000.0 -0.56 8973240.0 -1093088.3870968 -0.91915578298527 -1.7755 -0.9217 2144113 PK04_098122 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G03 mock treatment 8986520.0 131000.0 0.11 9977560.0 175000.0 0.15 1.041388E7 347551.6129032 0.292249079449368 0.318 0.9204 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G04 mock treatment 9107000.0 252000.0 0.22 1.0398E7 596000.0 0.49 1.026112E7 194791.6129032 0.163796303748627 0.5051 0.8954 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G05 compound treatment 8899680.0 44400.0 0.04 1.021984E7 418000.0 0.35 9960320.0 -106008.3870968 -0.0891402956935229 0.1707 0.4743 2141531 PK04_098123 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G06 compound treatment 2350880.0 -6500000.0 -5.6 3313040.0 -6490000.0 -5.38 3190000.0 -6876328.3870968 -5.78216462393547 -9.6782 -0.9996 2143985 PK04_098124 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G07 compound treatment 9370200.0 515000.0 0.44 9553160.0 -249000.0 -0.21 1.037556E7 309231.6129032 0.260026571169371 0.2868 0.5179 2065843 PK04_098125 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G08 compound treatment 4482160.0 -4370000.0 -3.76 5166800.0 -4640000.0 -3.85 5745840.0 -4320488.3870968 -3.6330107731435 -6.4906 -0.9997 2144713 PK04_098126 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G09 compound treatment 9002040.0 147000.0 0.13 1.025524E7 453000.0 0.38 1.039988E7 333551.6129032 0.280476764315757 0.4519 0.9303 2141779 PK04_098127 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G10 compound treatment 8618440.0 -237000.0 -0.2 1.001052E7 208000.0 0.17 1.033696E7 270631.6129032 0.227568616586701 0.1135 0.3234 2142633 PK04_098128 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G11 compound treatment 751640.0 -8100000.0 -6.97 987560.0 -8810000.0 -7.31 1011480.0 -9054848.3870968 -7.61403776428359 -12.6443 -0.9994 2141711 PK04_098129 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G12 compound treatment 8702680.0 -153000.0 -0.13 1.007036E7 268000.0 0.22 9632000.0 -434328.3870968 -0.365217903169742 -0.1582 -0.3536 2142689 PK04_098130 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G13 compound treatment 9213600.0 358000.0 0.31 1.061436E7 812000.0 0.67 1.065164E7 585311.6129032 0.492176625604174 0.8513 0.9569 2141802 PK04_098131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G14 compound treatment 7964720.0 -891000.0 -0.77 9636280.0 -166000.0 -0.14 9273120.0 -793208.3870968 -0.666992792823329 -0.907 -0.8846 2142905 PK04_098132 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G15 compound treatment 8994920.0 140000.0 0.12 1.02922E7 490000.0 0.41 1.03498E7 283471.6129032 0.238365511323527 0.4418 0.9082 2141192 PK04_098133 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G16 compound treatment 8147400.0 -708000.0 -0.61 9169360.0 -633000.0 -0.52 1.038728E7 320951.6129032 0.269881680695508 -0.499 -0.5882 2142129 PK04_098134 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G17 compound treatment 5968840.0 -2890000.0 -2.48 7859440.0 -1940000.0 -1.61 8693560.0 -1372768.3870968 -1.15433300416872 -3.0311 -0.9537 2141728 PK04_098135 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G18 compound treatment 8066240.0 -789000.0 -0.68 9516880.0 -285000.0 -0.24 9100640.0 -965688.3870968 -0.812027715269413 -0.9975 -0.9196 2144641 PK04_098136 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G19 mock treatment 8827840.0 -27400.0 -0.02 9965680.0 164000.0 0.14 1.0011E7 -55328.3870967999 -0.0465245149098521 0.0379 0.2604 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G20 mock treatment 8974080.0 119000.0 0.1 9888200.0 86100.0 0.07 1.064712E7 580791.6129032 0.488375849575323 0.3822 0.7583 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G21 compound treatment 8150240.0 -705000.0 -0.61 9708840.0 -93200.0 -0.08 9802280.0 -264048.3870968 -0.22203291595894 -0.5232 -0.804 2141885 PK04_098137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G22 compound treatment 8894920.0 39600.0 0.03 9697480.0 -105000.0 -0.09 9697880.0 -368448.3870968 -0.30982075166958 -0.2093 -0.6468 2144357 PK04_098138 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G23 compound treatment 8456600.0 -399000.0 -0.34 9653560.0 -149000.0 -0.12 9689560.0 -376768.3870968 -0.316816870377554 -0.4521 -0.9361 2141361 PK04_098139 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 G24 compound treatment 8088880.0 -766000.0 -0.66 9924560.0 122000.0 0.1 8783000.0 -1283328.3870968 -1.07912472805799 -0.9452 -0.7449 2142625 PK04_098140 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H01 compound treatment 8079800.0 -775000.0 -0.67 9263720.0 -538000.0 -0.45 8494200.0 -1572128.3870968 -1.32197077167133 -1.4064 -0.9093 2142737 PK04_098141 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H02 compound treatment 8352720.0 -503000.0 -0.43 9284280.0 -518000.0 -0.43 9621360.0 -444968.3870968 -0.374164862671286 -0.7137 -0.9979 2144017 PK04_098142 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H03 mock treatment 9002480.0 147000.0 0.13 9713720.0 -88300.0 -0.07 1.009252E7 26191.6129032001 0.0220239943538583 0.0435 0.2942 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H04 mock treatment 8840880.0 -14400.0 -0.01 1.048016E7 678000.0 0.56 1.002216E7 -44168.3870967999 -0.0371402979890596 0.2962 0.5252 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H05 compound treatment 8350600.0 -505000.0 -0.43 1.014228E7 340000.0 0.28 1.01678E7 101471.6129032 0.0853254145865879 -0.0386 -0.0735 2143493 PK04_098143 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H06 compound treatment 9327400.0 472000.0 0.41 9507520.0 -295000.0 -0.24 9881800.0 -184528.3870968 -0.155166166000031 0.0039 0.0079 2141857 PK04_098144 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H07 compound treatment 8665680.0 -190000.0 -0.16 9747440.0 -54600.0 -0.05 1.011724E7 50911.6129032001 0.0428105393612052 -0.0957 -0.5476 2143497 PK04_098145 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H08 compound treatment 7954200.0 -901000.0 -0.78 8724840.0 -1080000.0 -0.89 9346480.0 -719848.3870968 -0.605305861523209 -1.3132 -0.988 2141183 PK04_098146 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H09 compound treatment 8708400.0 -147000.0 -0.13 9947840.0 146000.0 0.12 1.044764E7 381311.6129032 0.320637176514418 0.182 0.4982 2143289 PK04_098147 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H10 compound treatment 8618240.0 -237000.0 -0.2 1.03366E7 535000.0 0.44 1.012856E7 62231.6129032001 0.0523292970263819 0.1684 0.3431 2142033 PK04_098148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H11 compound treatment 8966240.0 111000.0 0.1 1.012588E7 324000.0 0.27 1.086352E7 797191.6129032 0.670342206354848 0.5972 0.8199 2143345 PK04_098149 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H12 compound treatment 6741840.0 -2110000.0 -1.82 8707800.0 -1090000.0 -0.91 8566080.0 -1500248.3870968 -1.26152834225677 -2.3026 -0.9624 2141965 PK04_098150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H13 compound treatment 9390480.0 535000.0 0.46 9794800.0 -7270.0 -0.01 1.018304E7 116711.6129032 0.0981404204891756 0.3191 0.6775 2142053 PK04_098151 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H14 compound treatment 1.046348E7 1610000.0 1.38 1.01698E7 368000.0 0.31 1.060204E7 535711.6129032 0.450468994845096 1.2353 0.8306 2143285 PK04_098152 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H15 compound treatment 8624560.0 -231000.0 -0.2 1.00252E7 223000.0 0.19 9692440.0 -373888.3870968 -0.31439513697864 -0.1893 -0.4557 2143953 PK04_098153 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H16 compound treatment 7864040.0 -991000.0 -0.85 1.005608E7 254000.0 0.21 9557600.0 -508728.3870968 -0.427779349308359 -0.6179 -0.6322 2142849 PK04_098154 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H17 compound treatment 8885640.0 30400.0 0.03 9709240.0 -92800.0 -0.08 9817360.0 -248968.3870968 -0.209352450800736 -0.1502 -0.669 2142197 PK04_098155 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H18 compound treatment 4943320.0 -3910000.0 -3.37 5736760.0 -4070000.0 -3.37 6495640.0 -3570688.3870968 -3.00251920977341 -5.6244 -0.9986 2141678 PK04_098156 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H19 mock treatment 8883000.0 27700.0 0.02 1.021668E7 415000.0 0.34 1.049128E7 424951.6129032 0.357333164545187 0.4187 0.8431 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H20 mock treatment 9486720.0 631000.0 0.54 9987320.0 185000.0 0.15 9722360.0 -343968.3870968 -0.289236017778809 0.2355 0.3711 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H21 compound treatment 8494800.0 -360000.0 -0.31 1.028248E7 480000.0 0.4 1.072932E7 662991.6129032 0.557496157002666 0.3728 0.4956 2142657 PK04_098157 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H22 compound treatment 8091760.0 -764000.0 -0.66 8165120.0 -1640000.0 -1.36 9724800.0 -341528.3870968 -0.287184271426951 -1.3292 -0.8655 2141194 PK04_098158 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H23 compound treatment 7225080.0 -1630000.0 -1.4 8017600.0 -1780000.0 -1.48 8162160.0 -1904168.3870968 -1.60117645145448 -2.5891 -0.9985 2142665 PK04_098159 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 H24 compound treatment 8680920.0 -174000.0 -0.15 8889720.0 -912000.0 -0.76 9946160.0 -120168.3870968 -0.101047151571518 -0.5819 -0.7478 2141813 PK04_098160 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I01 compound treatment 5773680.0 -3080000.0 -2.65 7312160.0 -2490000.0 -2.07 6792160.0 -3274168.3870968 -2.75318157524353 -4.3133 -0.9927 2141395 PK04_098161 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I02 compound treatment 7561120.0 -1290000.0 -1.11 8928560.0 -874000.0 -0.72 9487000.0 -579328.3870968 -0.487145452767853 -1.3427 -0.9487 2144813 PK04_098162 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I03 compound treatment 3929120.0 -4930000.0 -4.24 5634440.0 -4170000.0 -3.46 7654600.0 -2411728.3870968 -2.02797332782702 -5.6147 -0.9623 2141107 PK04_098163 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I04 compound treatment 7409520.0 -1450000.0 -1.24 8689240.0 -1110000.0 -0.92 8945480.0 -1120848.3870968 -0.942498602135915 -1.7955 -0.9901 2142597 PK04_098164 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I05 mock treatment 8332680.0 -523000.0 -0.45 9811160.0 9090.0 0.01 9893880.0 -172448.3870968 -0.14500833979903 -0.339 -0.7174 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I06 mock treatment 9826360.0 971000.0 0.84 9671520.0 -131000.0 -0.11 1.031988E7 253551.6129032 0.213206392123696 0.5431 0.6248 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I07 compound treatment 8988560.0 133000.0 0.11 9889560.0 87500.0 0.07 1.012276E7 56431.6129032001 0.0474521950424574 0.1355 0.9425 2141144 PK04_098165 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I08 compound treatment 8670920.0 -184000.0 -0.16 9106200.0 -696000.0 -0.58 9846160.0 -220168.3870968 -0.185135116811594 -0.5318 -0.8486 2142693 PK04_098166 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I09 compound treatment 8659440.0 -196000.0 -0.17 9127400.0 -675000.0 -0.56 9952400.0 -113928.3870968 -0.0958000625405369 -0.4758 -0.8032 2141896 PK04_098167 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I10 compound treatment 8902640.0 47400.0 0.04 1.035484E7 553000.0 0.46 9751360.0 -314968.3870968 -0.264850507859187 0.1354 0.2549 2141957 PK04_098168 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I11 compound treatment 8418520.0 -437000.0 -0.38 8661200.0 -1140000.0 -0.95 8852320.0 -1214008.3870968 -1.02083495055357 -1.3528 -0.9382 2141394 PK04_098169 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I12 compound treatment 9128440.0 273000.0 0.24 1.035556E7 553000.0 0.46 1.096884E7 902511.6129032 0.758903651345697 0.839 0.9143 2142049 PK04_098170 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I13 compound treatment 8619680.0 -236000.0 -0.2 1.046752E7 665000.0 0.55 1.00814E7 15071.6129032001 0.0126734126191618 0.209 0.3552 2141346 PK04_098171 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I14 compound treatment 8325400.0 -530000.0 -0.46 9164760.0 -637000.0 -0.53 9711640.0 -354688.3870968 -0.298250247652545 -0.7407 -0.9756 2143477 PK04_098172 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I15 compound treatment 6040280.0 -2810000.0 -2.42 8304960.0 -1500000.0 -1.24 8505000.0 -1561328.3870968 -1.3128892714254 -2.8738 -0.9508 2141373 PK04_098173 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I16 compound treatment 7714440.0 -1140000.0 -0.98 9491000.0 -311000.0 -0.26 9996760.0 -69568.3870967999 -0.058498641160039 -0.7496 -0.7372 2144645 PK04_098174 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I17 compound treatment 9170120.0 315000.0 0.27 1.017684E7 375000.0 0.31 9678720.0 -387608.3870968 -0.325932005809578 0.1478 0.2811 2141116 PK04_098175 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I18 compound treatment 9260760.0 405000.0 0.35 1.02402E7 438000.0 0.36 9922120.0 -144208.3870968 -0.121261898415232 0.3413 0.6586 2142097 PK04_098176 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I19 compound treatment 8788240.0 -67000.0 -0.06 1.018364E7 382000.0 0.32 1.06722E7 605871.6129032 0.509465111257534 0.4436 0.7362 2141442 PK04_098177 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I20 compound treatment 8925920.0 70600.0 0.06 9350120.0 -452000.0 -0.37 1.003164E7 -34688.3870967999 -0.0291687588843003 -0.1982 -0.5203 2142005 PK04_098178 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I21 mock treatment 8520280.0 -335000.0 -0.29 9689760.0 -112000.0 -0.09 9960160.0 -106168.3870968 -0.089274836437907 -0.2718 -0.8604 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I22 mock treatment 8318280.0 -537000.0 -0.46 1.013144E7 329000.0 0.27 9975360.0 -90968.3870967999 -0.0764934657214154 -0.1532 -0.2826 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I23 compound treatment 8254040.0 -601000.0 -0.52 9012760.0 -789000.0 -0.65 1.003732E7 -29008.3870967999 -0.024392562458664 -0.6909 -0.8275 2141137 PK04_098179 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 I24 compound treatment 7480800.0 -1370000.0 -1.18 8895240.0 -907000.0 -0.75 8369840.0 -1696488.3870968 -1.42654256524389 -1.9409 -0.9704 2144905 PK04_098180 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J01 compound treatment 7249760.0 -1610000.0 -1.38 8019600.0 -1780000.0 -1.48 8094240.0 -1972088.3870968 -1.65828899744554 -2.6089 -0.9971 2142853 PK04_098181 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J02 compound treatment 8340080.0 -515000.0 -0.44 9509880.0 -292000.0 -0.24 9730280.0 -336048.3870968 -0.282576250931795 -0.5591 -0.9657 2141434 PK04_098182 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J03 compound treatment 5972400.0 -2880000.0 -2.48 6581560.0 -3220000.0 -2.67 8709520.0 -1356808.3870968 -1.1409125649164 -3.6337 -0.9511 2142925 PK04_098183 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J04 compound treatment 8748480.0 -107000.0 -0.09 9476360.0 -326000.0 -0.27 9833120.0 -233208.3870968 -0.1961001874789 -0.3223 -0.9307 2141810 PK04_098184 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J05 mock treatment 8772120.0 -83200.0 -0.07 9781720.0 -20300.0 -0.02 1.010508E7 38751.6129032001 0.0325854427880119 -0.0323 -0.401 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J06 mock treatment 9258200.0 403000.0 0.35 9837720.0 35700.0 0.03 1.023356E7 167231.6129032 0.140621660528462 0.2985 0.7952 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J07 compound treatment 8660520.0 -195000.0 -0.17 1.034072E7 539000.0 0.45 1.035624E7 289911.6129032 0.243780776284988 0.302 0.5635 2143253 PK04_098185 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J08 compound treatment 8383000.0 -472000.0 -0.41 9172520.0 -630000.0 -0.52 9665480.0 -400848.3870968 -0.337065252407364 -0.7308 -0.984 2141219 PK04_098186 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J09 compound treatment 9171000.0 316000.0 0.27 1.041364E7 612000.0 0.51 9440720.0 -625608.3870968 -0.52606136308096 0.1461 0.1873 2142945 PK04_098187 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J10 compound treatment 9410400.0 555000.0 0.48 1.057532E7 773000.0 0.64 1.05708E7 504471.6129032 0.424199914504096 0.8911 0.9842 2141450 PK04_098188 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J11 compound treatment 1.005224E7 1200000.0 1.03 9979480.0 177000.0 0.15 1.038612E7 319791.6129032 0.268906260298723 0.835 0.7769 2144285 PK04_098189 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J12 compound treatment 6349200.0 -2510000.0 -2.16 7795680.0 -2010000.0 -1.66 9797120.0 -269208.3870968 -0.226371854965328 -2.3369 -0.8548 2141139 PK04_098190 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J13 compound treatment 8829920.0 -25400.0 -0.02 9876080.0 74000.0 0.06 9487840.0 -578488.3870968 -0.486439113859836 -0.258 -0.5257 2143473 PK04_098191 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J14 compound treatment 8898520.0 43200.0 0.04 1.0781E7 979000.0 0.81 1.006388E7 -2448.38709679991 -0.00205879889089963 0.4892 0.6017 2144013 PK04_098192 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J15 compound treatment 6981440.0 -1870000.0 -1.61 8117760.0 -1680000.0 -1.4 8386440.0 -1679888.3870968 -1.41258396301404 -2.5534 -0.9978 2142837 PK04_098193 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J16 compound treatment 9676000.0 821000.0 0.71 1.030632E7 504000.0 0.42 9380280.0 -686048.3870968 -0.576884129272063 0.3163 0.3152 2141784 PK04_098194 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J17 compound treatment 8692760.0 -163000.0 -0.14 9189120.0 -613000.0 -0.51 9617760.0 -448568.3870968 -0.377192029419929 -0.5921 -0.9132 2144425 PK04_098195 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J18 compound treatment 6395000.0 -2460000.0 -2.12 8012200.0 -1790000.0 -1.48 8535880.0 -1530448.3870968 -1.28692290775927 -2.8228 -0.9772 2141332 PK04_098196 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J19 compound treatment 9044760.0 189000.0 0.16 9735000.0 -67100.0 -0.06 1.011828E7 51951.6129032001 0.043685054199702 0.0873 0.4908 2143957 PK04_098197 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J20 compound treatment 8879120.0 23800.0 0.02 9107080.0 -695000.0 -0.58 1.016716E7 100831.6129032 0.0847872516090514 -0.2721 -0.4666 2141933 PK04_098198 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J21 mock treatment 8858040.0 2760.0 0.0 9165400.0 -637000.0 -0.53 9731240.0 -335088.3870968 -0.28176900646549 -0.4662 -0.7789 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J22 mock treatment 8744800.0 -110000.0 -0.1 9601400.0 -201000.0 -0.17 1.014492E7 78591.6129032001 0.0660860881396584 -0.1129 -0.5565 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J23 compound treatment 7623800.0 -1230000.0 -1.06 8728600.0 -1070000.0 -0.89 8200720.0 -1865608.3870968 -1.56875213205791 -2.0318 -0.9711 2144049 PK04_098199 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 J24 compound treatment 8074560.0 -781000.0 -0.67 7916120.0 -1890000.0 -1.56 7782280.0 -2284048.3870968 -1.92060981380849 -2.4001 -0.9351 2141196 PK04_098200 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K01 compound treatment 7857720.0 -998000.0 -0.86 9099240.0 -703000.0 -0.58 8412080.0 -1654248.3870968 -1.39102380872648 -1.6354 -0.9423 2141522 PK04_098201 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K02 compound treatment 8106520.0 -749000.0 -0.64 9443200.0 -359000.0 -0.3 9492040.0 -574288.3870968 -0.482907419319753 -0.8227 -0.9583 2142617 PK04_098202 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K03 compound treatment 8481600.0 -374000.0 -0.32 1.037044E7 568000.0 0.47 9815000.0 -251328.3870968 -0.211336926780402 -0.0355 -0.0583 2141439 PK04_098203 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K04 compound treatment 8818360.0 -36900.0 -0.03 9607920.0 -194000.0 -0.16 1.011556E7 49231.6129032001 0.0413978615451719 -0.0874 -0.5164 2143329 PK04_098204 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K05 compound treatment 7536320.0 -1320000.0 -1.14 8740120.0 -1060000.0 -0.88 9516040.0 -550288.3870968 -0.462726307662135 -1.4312 -0.9481 2141725 PK04_098205 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K06 compound treatment 8726720.0 -129000.0 -0.11 1.024108E7 439000.0 0.36 9548200.0 -518128.3870968 -0.435683618040926 -0.1052 -0.1818 2142973 PK04_098206 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K07 mock treatment 9229120.0 374000.0 0.32 9428280.0 -374000.0 -0.31 1.045072E7 384391.6129032 0.323227085843812 0.1933 0.3506 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K08 mock treatment 9763720.0 908000.0 0.78 9720960.0 -81100.0 -0.07 1.011816E7 51831.6129032001 0.0435841486414139 0.4377 0.5569 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K09 compound treatment 2271720.0 -6580000.0 -5.67 3228080.0 -6570000.0 -5.45 3887560.0 -6178768.3870968 -5.19560061360679 -9.4196 -0.9994 2141136 PK04_098207 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K10 compound treatment 9057440.0 202000.0 0.17 1.045892E7 657000.0 0.54 1.011544E7 49111.6129032001 0.0412969559868838 0.4389 0.7653 2143005 PK04_098208 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K11 compound treatment 1854320.0 -7000000.0 -6.03 2012280.0 -7790000.0 -6.46 3303720.0 -6762608.3870968 -5.68653978986446 -10.4928 -0.9986 2141925 PK04_098209 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K12 compound treatment 8558080.0 -297000.0 -0.26 8974520.0 -828000.0 -0.69 9027360.0 -1038968.3870968 -0.873647376197341 -1.0484 -0.9195 2144741 PK04_098210 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K13 compound treatment 8999680.0 144000.0 0.12 9846640.0 44600.0 0.04 9931760.0 -134568.3870968 -0.113155818566089 0.0278 0.1614 2141147 PK04_098211 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K14 compound treatment 8090160.0 -765000.0 -0.66 9160160.0 -642000.0 -0.53 9691640.0 -374688.3870968 -0.31506784070056 -0.8695 -0.9623 2143465 PK04_098212 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K15 mock treatment 9380960.0 526000.0 0.45 1.009696E7 295000.0 0.24 9722640.0 -343688.3870968 -0.289000571476137 0.2356 0.3993 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K16 mock treatment 9137320.0 282000.0 0.24 1.043568E7 634000.0 0.53 1.0522E7 455671.6129032 0.383164987466939 0.6648 0.9576 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K17 compound treatment 8727920.0 -127000.0 -0.11 9745240.0 -56800.0 -0.05 9947880.0 -118448.3870968 -0.0996008385693884 -0.148 -0.9523 2141530 PK04_098213 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K18 compound treatment 8750680.0 -105000.0 -0.09 1.0452E7 650000.0 0.54 1.060512E7 538791.6129032 0.453058904174491 0.5209 0.7337 2143169 PK04_098214 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K19 compound treatment 8986680.0 131000.0 0.11 9757800.0 -44300.0 -0.04 1.017028E7 103951.6129032 0.0874107961245418 0.0946 0.6407 2141707 PK04_098215 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K20 compound treatment 9018080.0 163000.0 0.14 9958160.0 156000.0 0.13 1.054432E7 477991.6129032 0.401933421308524 0.3877 0.8714 2143073 PK04_098216 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K21 compound treatment 8850920.0 -4360.0 0.0 9876200.0 74100.0 0.06 9866200.0 -200128.3870968 -0.168283888577483 -0.0638 -0.3561 2141428 PK04_098217 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K22 compound treatment 1509320.0 -7350000.0 -6.32 1657680.0 -8140000.0 -6.76 2224680.0 -7841648.3870968 -6.59388256999098 -11.3579 -0.9996 2142725 PK04_098218 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K23 mock treatment 8957760.0 102000.0 0.09 9280880.0 -521000.0 -0.43 9983320.0 -83008.3870967999 -0.0698000636883053 -0.239 -0.535 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 K24 mock treatment 8306160.0 -549000.0 -0.47 9337000.0 -465000.0 -0.39 9495360.0 -570968.3870968 -0.480115698873783 -0.7728 -0.9954 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L01 compound treatment 8016200.0 -839000.0 -0.72 9071640.0 -730000.0 -0.61 9485200.0 -581128.3870968 -0.488659036142174 -1.0489 -0.9878 2143889 PK04_098219 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L02 compound treatment 5942360.0 -2910000.0 -2.51 5980720.0 -3820000.0 -3.17 6186080.0 -3880248.3870968 -3.26282191497059 -5.1614 -0.9937 2141700 PK04_098220 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L03 compound treatment 7225880.0 -1630000.0 -1.4 8108840.0 -1690000.0 -1.4 8233120.0 -1833208.3870968 -1.54150763132012 -2.5106 -0.999 2142733 PK04_098221 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L04 compound treatment 9287720.0 432000.0 0.37 1.046072E7 659000.0 0.55 1.039572E7 329391.6129032 0.27697870496177 0.6903 0.963 2141934 PK04_098222 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L05 compound treatment 8737160.0 -118000.0 -0.1 1.050896E7 707000.0 0.59 1.017744E7 111111.6129032 0.0934314944357313 0.3338 0.5541 2143873 PK04_098223 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L06 compound treatment 8819480.0 -35800.0 -0.03 1.087876E7 1080000.0 0.89 1.105652E7 990191.6129032 0.832631979268196 0.9786 0.8012 2141797 PK04_098224 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L07 mock treatment 4972920.0 -3880000.0 -3.34 6591560.0 -3210000.0 -2.66 6573080.0 -3493248.3870968 -2.93740148949149 -5.1627 -0.9957 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L08 mock treatment 9072200.0 217000.0 0.19 1.015956E7 357000.0 0.3 9740760.0 -325568.3870968 -0.273763832174635 0.121 0.272 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L09 compound treatment 9035680.0 180000.0 0.16 1.014952E7 347000.0 0.29 1.042416E7 357831.6129032 0.300893322276048 0.4298 0.9665 2142957 PK04_098225 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L10 compound treatment 8159120.0 -696000.0 -0.6 1.026288E7 461000.0 0.38 1.06012E7 534871.6129032 0.44976265593708 0.1345 0.1599 3413983 PK04_098226 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L11 compound treatment 3112600.0 -5740000.0 -4.94 4284680.0 -5520000.0 -4.58 4285360.0 -5780968.3870968 -4.86109868788177 -8.3026 -0.9995 2142717 PK04_098227 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L12 compound treatment 9633600.0 778000.0 0.67 1.049544E7 693000.0 0.58 1.033624E7 269911.6129032 0.226963183236973 0.8499 0.9323 3413985 PK04_098228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L13 compound treatment 9210600.0 355000.0 0.31 1.093076E7 1130000.0 0.94 1.05878E7 521471.6129032 0.438494868594909 0.9703 0.8999 2143357 PK04_098229 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L14 compound treatment 6426480.0 -2430000.0 -2.09 7655360.0 -2150000.0 -1.78 7613520.0 -2452808.3870968 -2.06251666394764 -3.4258 -0.9975 3413987 PK04_098230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L15 mock treatment 9233600.0 378000.0 0.33 1.027348E7 471000.0 0.39 1.019508E7 128751.6129032 0.108264611504081 0.4763 0.9155 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L16 mock treatment 9242120.0 387000.0 0.33 1.016088E7 359000.0 0.3 1.015024E7 83911.6129032001 0.0705595678904305 0.4048 0.8953 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L17 compound treatment 8757080.0 -98200.0 -0.08 9961440.0 159000.0 0.13 1.05148E7 448471.6129032 0.377110653969653 0.2453 0.6005 2143089 PK04_098231 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L18 compound treatment 8635000.0 -220000.0 -0.19 8836560.0 -966000.0 -0.8 9526280.0 -540048.3870968 -0.454115700021551 -0.8341 -0.8873 3413990 PK04_098232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L19 compound treatment 8874720.0 19400.0 0.02 9720480.0 -81600.0 -0.07 9373080.0 -693248.3870968 -0.582938462769348 -0.366 -0.6234 2144137 PK04_098233 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L20 compound treatment 8431280.0 -424000.0 -0.36 9212200.0 -590000.0 -0.49 9652800.0 -413528.3870968 -0.347727606399806 -0.694 -0.9878 3413992 PK04_098234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L21 compound treatment 8515680.0 -340000.0 -0.29 9188800.0 -613000.0 -0.51 9379520.0 -686808.3870968 -0.577523197807887 -0.7959 -0.9668 2143369 PK04_098235 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L22 compound treatment 8043680.0 -812000.0 -0.7 8506600.0 -1300000.0 -1.07 8701680.0 -1364648.3870968 -1.14750506139122 -1.6863 -0.9802 3413998 PK04_098236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5cccc(Br)c5)C/C=C/C[C@@H](Cc6cccc(Br)c6)C(=O)O[C@@H]14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L23 mock treatment 8864080.0 8800.0 0.01 9809280.0 7210.0 0.01 9874280.0 -192048.3870968 -0.161489580986085 -0.0854 -0.5279 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 L24 mock treatment 8302240.0 -553000.0 -0.48 9046360.0 -756000.0 -0.63 9062640.0 -1003688.3870968 -0.843981142060642 -1.124 -0.974 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M01 compound treatment 7886520.0 -969000.0 -0.83 8856680.0 -945000.0 -0.78 8694080.0 -1372248.3870968 -1.15389574674947 -1.6004 -0.9846 2141977 PK04_098237 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M02 compound treatment 7777840.0 -1080000.0 -0.93 9789800.0 -12300.0 -0.01 9638760.0 -427568.3870968 -0.359533556719513 -0.7488 -0.7529 2144277 PK04_098238 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M03 compound treatment 7963200.0 -892000.0 -0.77 8819400.0 -983000.0 -0.82 9337360.0 -728968.3870968 -0.612974683953104 -1.2678 -0.9931 2143353 PK04_098239 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M04 compound treatment 6277960.0 -2580000.0 -2.22 7725360.0 -2080000.0 -1.72 8379560.0 -1686768.3870968 -1.41836921502256 -3.0942 -0.9834 2142753 PK04_098240 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M05 compound treatment 8001440.0 -854000.0 -0.73 1.005648E7 254000.0 0.21 9128080.0 -938248.3870968 -0.788953977607536 -0.7579 -0.6899 2142713 PK04_098241 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M06 compound treatment 8176040.0 -679000.0 -0.58 9802240.0 172.0 0.0 1.00708E7 4471.61290320009 0.00376008830371367 -0.3353 -0.5735 2143893 PK04_098242 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M07 compound treatment 8178360.0 -677000.0 -0.58 9512040.0 -290000.0 -0.24 9785840.0 -280488.3870968 -0.235856977444408 -0.6114 -0.9085 2143173 PK04_098243 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M08 compound treatment 8088840.0 -766000.0 -0.66 9562520.0 -240000.0 -0.2 9930360.0 -135968.3870968 -0.11433305007945 -0.5616 -0.8042 2143913 PK04_098244 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M09 mock treatment 8744760.0 -111000.0 -0.1 9471960.0 -330000.0 -0.27 9730880.0 -335448.3870968 -0.282071723140354 -0.3759 -0.9293 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M10 mock treatment 9189160.0 334000.0 0.29 1.005372E7 252000.0 0.21 1.066668E7 600351.6129032 0.504823455576282 0.5779 0.9362 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M11 compound treatment 7607000.0 -1250000.0 -1.07 8778040.0 -1020000.0 -0.85 8776720.0 -1289608.3870968 -1.08440545227507 -1.7368 -0.9942 2143965 PK04_098245 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M12 compound treatment 8482880.0 -372000.0 -0.32 9521040.0 -281000.0 -0.23 1.073196E7 665631.6129032 0.559716079285004 0.0035 0.0051 2144453 PK04_098246 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M13 mock treatment 8732240.0 -123000.0 -0.11 1.021564E7 414000.0 0.34 1.078076E7 714431.6129032 0.600751006322161 0.4838 0.6913 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M14 mock treatment 9107760.0 252000.0 0.22 9846440.0 44400.0 0.04 1.05536E7 487271.6129032 0.409736784482803 0.3833 0.8238 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M15 compound treatment 8587240.0 -268000.0 -0.23 9448320.0 -354000.0 -0.29 9701000.0 -365328.3870968 -0.307197207154089 -0.48 -0.9929 2142065 PK04_098247 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M16 compound treatment 9228800.0 374000.0 0.32 1.022516E7 423000.0 0.35 1.0303E7 236671.6129032 0.199012343591171 0.5031 0.9753 2143293 PK04_098248 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M17 compound treatment 8622280.0 -233000.0 -0.2 9254160.0 -548000.0 -0.45 9816520.0 -249808.3870968 -0.210058789708753 -0.4995 -0.926 2142857 PK04_098249 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M18 compound treatment 8752040.0 -103000.0 -0.09 9629840.0 -172000.0 -0.14 9553560.0 -512768.3870968 -0.431176503104058 -0.3827 -0.8269 2142613 PK04_098250 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M19 compound treatment 9112840.0 258000.0 0.22 9729880.0 -72200.0 -0.06 9434520.0 -631808.3870968 -0.531274816925845 -0.2133 -0.3686 2142697 PK04_098251 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M20 compound treatment 8630800.0 -224000.0 -0.19 9272360.0 -530000.0 -0.44 9041800.0 -1024528.3870968 -0.861505074016674 -0.8626 -0.8747 2144821 PK04_098252 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M21 compound treatment 8423400.0 -432000.0 -0.37 9722840.0 -79200.0 -0.07 9950200.0 -116128.3870968 -0.0976499977758186 -0.3089 -0.7923 2142965 PK04_098253 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M22 compound treatment 8453160.0 -402000.0 -0.35 9367320.0 -435000.0 -0.36 9600000.0 -466328.3870968 -0.392126052046567 -0.6344 -0.9986 2144777 PK04_098254 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M23 compound treatment 8504200.0 -351000.0 -0.3 9074720.0 -727000.0 -0.6 9688480.0 -377848.3870968 -0.317725020402147 -0.7063 -0.9469 2141143 PK04_098255 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 M24 compound treatment 7292680.0 -1560000.0 -1.34 6372000.0 -3430000.0 -2.85 7187160.0 -2879168.3870968 -2.42103411254523 -3.8171 -0.9613 2144937 PK04_098256 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N01 compound treatment 7106160.0 -1750000.0 -1.51 7812600.0 -1990000.0 -1.65 7508920.0 -2557408.3870968 -2.15047267558876 -3.0636 -0.988 2144901 PK04_098257 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N02 compound treatment 7385480.0 -1470000.0 -1.26 8050320.0 -1750000.0 -1.45 7821040.0 -2245288.3870968 -1.88801731848143 -2.6594 -0.9859 3413999 PK04_098258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N03 compound treatment 8812560.0 -42700.0 -0.04 9486560.0 -316000.0 -0.26 9737000.0 -329328.3870968 -0.276925539667662 -0.3322 -0.8678 2143297 PK04_098259 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N04 compound treatment 6148440.0 -2710000.0 -2.33 7538280.0 -2260000.0 -1.88 7290120.0 -2776208.3870968 -2.33445714353405 -3.777 -0.9952 3414005 PK04_098260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N05 compound treatment 8400760.0 -455000.0 -0.39 1.05964E7 794000.0 0.66 1.017428E7 107951.6129032 0.0907743147341449 0.207 0.2683 2142017 PK04_098261 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N06 compound treatment 8901840.0 46600.0 0.04 1.008156E7 279000.0 0.23 1.02664E7 200071.6129032 0.168236148313303 0.2541 0.8786 3188747 PK04_098262 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)CCc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N07 compound treatment 8867440.0 12200.0 0.01 1.001776E7 216000.0 0.18 9957360.0 -108968.3870968 -0.0916292994646291 0.0564 0.2804 2143017 PK04_098263 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N08 compound treatment 6508000.0 -2350000.0 -2.02 7068200.0 -2730000.0 -2.27 7890320.0 -2176008.3870968 -1.82976117616311 -3.5321 -0.9962 3188748 PK04_098264 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N09 mock treatment 9062680.0 207000.0 0.18 9852800.0 50700.0 0.04 9991680.0 -74648.3870967999 -0.0627703097942349 0.0911 0.4701 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N10 mock treatment 8577800.0 -277000.0 -0.24 9876680.0 74600.0 0.06 9723800.0 -342528.3870968 -0.288025151079352 -0.2684 -0.7078 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N11 compound treatment 8659600.0 -196000.0 -0.17 1.094392E7 1140000.0 0.95 9682080.0 -384248.3870968 -0.323106650177512 0.2631 0.2593 2144265 PK04_098265 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N12 compound treatment 4586840.0 -4270000.0 -3.67 5603840.0 -4200000.0 -3.48 9670320.0 -396008.3870968 -0.332995394889745 -4.324 -0.8523 3069249 PK04_098266 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3c(OC)cccc3OC)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N13 mock treatment 8747920.0 -107000.0 -0.09 1.042228E7 620000.0 0.51 1.044548E7 379151.6129032 0.318820876465232 0.4278 0.6986 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N14 mock treatment 8464640.0 -391000.0 -0.34 9649680.0 -152000.0 -0.13 9960200.0 -106128.3870968 -0.089241201251811 -0.3186 -0.8609 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N15 compound treatment 8280520.0 -575000.0 -0.49 9414600.0 -387000.0 -0.32 9089520.0 -976808.3870968 -0.821378297004109 -0.9454 -0.9349 2143165 PK04_098267 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N16 compound treatment 7266640.0 -1590000.0 -1.37 8884960.0 -917000.0 -0.76 8358920.0 -1707408.3870968 -1.43572497104811 -2.0575 -0.9689 3188751 PK04_098268 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N17 compound treatment 8044920.0 -810000.0 -0.7 9336680.0 -465000.0 -0.39 9585840.0 -480488.3870968 -0.404032907924561 -0.8588 -0.961 2144365 PK04_098269 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N18 compound treatment 1937920.0 -6920000.0 -5.95 2084440.0 -7720000.0 -6.4 2100080.0 -7966248.3870968 -6.69865617468011 -11.001 -0.9988 3188752 PK04_098270 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3cccc(F)c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N19 compound treatment 7040640.0 -1810000.0 -1.56 7953560.0 -1850000.0 -1.53 8059080.0 -2007248.3870968 -1.68785432602395 -2.7615 -0.9991 2142105 PK04_098271 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N20 compound treatment 7747880.0 -1110000.0 -0.95 8063400.0 -1740000.0 -1.44 7956760.0 -2109568.3870968 -1.7738931320576 -2.4072 -0.9718 3068687 PK04_098272 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(OC)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N21 compound treatment 8302000.0 -553000.0 -0.48 9467960.0 -334000.0 -0.28 9378560.0 -687768.3870968 -0.578330442274192 -0.7688 -0.9625 2144245 PK04_098273 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N22 compound treatment 2085720.0 -6770000.0 -5.83 2066080.0 -7740000.0 -6.42 2052880.0 -8013448.3870968 -6.73834569427343 -10.9593 -0.9982 3068689 PK04_098274 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N23 compound treatment 8052960.0 -802000.0 -0.69 8631320.0 -1170000.0 -0.97 9390200.0 -676128.3870968 -0.568542603120247 -1.2876 -0.9752 2143153 PK04_098275 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 N24 compound treatment 440440.0 -8410000.0 -7.24 500360.0 -9300000.0 -7.72 468600.0 -9597728.3870968 -8.07053450997891 -13.2959 -0.999 3188876 PK04_098276 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O01 compound treatment 7359400.0 -1500000.0 -1.29 8128320.0 -1670000.0 -1.39 8211200.0 -1855128.3870968 -1.55993971330075 -2.4456 -0.9968 2143373 PK04_098277 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O02 compound treatment 7680120.0 -1180000.0 -1.01 9460080.0 -342000.0 -0.28 8955000.0 -1111328.3870968 -0.93449342784506 -1.2873 -0.9156 2142209 PK04_098278 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O03 compound treatment 8615240.0 -240000.0 -0.21 9427880.0 -374000.0 -0.31 9835520.0 -230808.3870968 -0.194082076313138 -0.4105 -0.9766 2144345 PK04_098279 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O04 compound treatment 8199640.0 -656000.0 -0.56 9148160.0 -654000.0 -0.54 8934160.0 -1132168.3870968 -0.952017359801092 -1.1886 -0.9644 2142673 PK04_098280 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O05 compound treatment 7956840.0 -898000.0 -0.77 8843280.0 -959000.0 -0.8 9196840.0 -869488.3870968 -0.731135092708459 -1.3278 -0.9994 2143977 PK04_098281 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O06 compound treatment 8784840.0 -70400.0 -0.06 9678400.0 -124000.0 -0.1 9546480.0 -519848.3870968 -0.437129931043056 -0.3466 -0.765 2142077 PK04_098282 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O07 compound treatment 8813200.0 -42100.0 -0.04 9596120.0 -206000.0 -0.17 1.029052E7 224191.6129032 0.18851816552921 -0.0107 -0.0417 2141985 PK04_098283 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O08 compound treatment 6701120.0 -2150000.0 -1.85 7086040.0 -2720000.0 -2.25 8089440.0 -1976888.3870968 -1.66232521977707 -3.331 -0.9919 2143485 PK04_098284 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O09 compound treatment 8807360.0 -47900.0 -0.04 9543160.0 -259000.0 -0.21 9617920.0 -448408.3870968 -0.377057488675545 -0.3655 -0.8385 2144665 PK04_098285 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O10 compound treatment 9201520.0 346000.0 0.3 9888320.0 86300.0 0.07 1.03092E7 242871.6129032 0.204225797436056 0.3313 0.8995 2143273 PK04_098286 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O11 mock treatment 9167800.0 313000.0 0.27 1.06858E7 884000.0 0.73 1.058068E7 514351.6129032 0.432507805469816 0.8283 0.9278 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O12 mock treatment 9211680.0 356000.0 0.31 9604560.0 -198000.0 -0.16 1.007696E7 10631.6129032001 0.00893990696250238 0.0877 0.252 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O13 compound treatment 8848680.0 -6600.0 -0.01 1.01308E7 329000.0 0.27 9333320.0 -733008.3870968 -0.616371837748803 -0.2017 -0.2992 2144773 PK04_098287 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O14 compound treatment 8015160.0 -840000.0 -0.72 9849600.0 47500.0 0.04 9679320.0 -387008.3870968 -0.325427478018138 -0.5826 -0.7338 2143945 PK04_098288 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O15 compound treatment 8814280.0 -41000.0 -0.04 1.029048E7 488000.0 0.41 1.030236E7 236031.6129032 0.198474180613635 0.3281 0.7251 2144317 PK04_098289 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O16 compound treatment 8549560.0 -306000.0 -0.26 9888080.0 86000.0 0.07 1.026964E7 203311.6129032 0.170960598387082 -0.012 -0.0373 2143905 PK04_098290 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O17 compound treatment 8598840.0 -256000.0 -0.22 9541440.0 -261000.0 -0.22 9572160.0 -494168.3870968 -0.415536141569404 -0.4922 -0.9505 2143917 PK04_098291 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O18 compound treatment 8692480.0 -163000.0 -0.14 1.003888E7 237000.0 0.2 9591600.0 -474728.3870968 -0.399189441126733 -0.1979 -0.4244 2144253 PK04_098292 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O19 compound treatment 6345280.0 -2510000.0 -2.16 6570880.0 -3230000.0 -2.68 6997720.0 -3068608.3870968 -2.58033035389603 -4.2845 -0.9959 2144105 PK04_098293 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O20 compound treatment 8349360.0 -506000.0 -0.44 9627320.0 -175000.0 -0.14 9766480.0 -299848.3870968 -0.252136407514887 -0.4807 -0.918 2144293 PK04_098294 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O21 compound treatment 8477080.0 -378000.0 -0.33 9702960.0 -99100.0 -0.08 9619840.0 -446488.3870968 -0.375442999742935 -0.4522 -0.8978 2142997 PK04_098295 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O22 compound treatment 6687800.0 -2170000.0 -1.87 7771920.0 -2030000.0 -1.68 8045280.0 -2021048.3870968 -1.69945846522708 -3.0305 -0.9989 2144737 PK04_098296 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O23 compound treatment 8454720.0 -401000.0 -0.34 8942920.0 -859000.0 -0.71 8544920.0 -1521408.3870968 -1.27932135570157 -1.3491 -0.8967 2141452 PK04_098297 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 O24 compound treatment 6785600.0 -2070000.0 -1.78 7838960.0 -1960000.0 -1.63 7948680.0 -2117648.3870968 -1.780687439649 -2.9967 -0.9991 2142677 PK04_098298 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P01 compound treatment 1117440.0 -7740000.0 -6.66 1583240.0 -8220000.0 -6.82 1635640.0 -8430688.3870968 -7.08919432044112 -11.8742 -0.9997 2144005 PK04_098299 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P02 compound treatment 631680.0 -8220000.0 -7.08 744160.0 -9060000.0 -7.51 951480.0 -9114848.3870968 -7.66449054342763 -12.8496 -0.9994 3068772 PK04_098300 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(C#N)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P03 compound treatment 7971440.0 -884000.0 -0.76 8581400.0 -1220000.0 -1.01 8398960.0 -1667368.3870968 -1.40205614976598 -1.8333 -0.9703 2142593 PK04_098301 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P04 compound treatment 6669480.0 -2190000.0 -1.88 7331800.0 -2470000.0 -2.05 7604920.0 -2461408.3870968 -2.06974822895829 -3.4642 -0.9991 3000699 PK04_098302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P05 compound treatment 6673720.0 -2180000.0 -1.88 9123920.0 -678000.0 -0.56 9101440.0 -964888.3870968 -0.811355011547492 -1.8772 -0.8849 2144921 PK04_098303 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P06 compound treatment 2519040.0 -6340000.0 -5.45 3377640.0 -6420000.0 -5.33 3066720.0 -6999608.3870968 -5.88582826748344 -9.6236 -0.9991 3000700 PK04_098304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P07 compound treatment 1.087272E7 2020000.0 1.74 9330200.0 -472000.0 -0.39 8725160.0 -1341168.3870968 -1.12776120715285 0.1253 0.0595 2143937 PK04_098305 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P08 compound treatment 6241280.0 -2610000.0 -2.25 7139520.0 -2660000.0 -2.21 6302720.0 -3763608.3870968 -3.16474171231456 -4.4013 -0.9853 3000701 PK04_098306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P09 compound treatment 8532960.0 -322000.0 -0.28 8945360.0 -857000.0 -0.71 8754680.0 -1311648.3870968 -1.10293843981398 -1.2073 -0.9002 2144785 PK04_098307 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P10 compound treatment 7587440.0 -1270000.0 -1.09 7632080.0 -2170000.0 -1.8 7145840.0 -2920488.3870968 -2.45577925978243 -3.0871 -0.9544 3089322 PK04_098308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P11 mock treatment 8240680.0 -615000.0 -0.53 9615160.0 -187000.0 -0.16 9207720.0 -858608.3870968 -0.721986322090339 -0.8117 -0.8937 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P12 mock treatment 8238080.0 -617000.0 -0.53 9220280.0 -582000.0 -0.48 8687680.0 -1378648.3870968 -1.15927737652483 -1.2546 -0.9202 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P13 compound treatment 4406920.0 -4450000.0 -3.83 5042360.0 -4760000.0 -3.95 5435120.0 -4631208.3870968 -3.89428889873747 -6.7384 -0.9999 2144213 PK04_098309 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P14 compound treatment 4969160.0 -3890000.0 -3.34 6221440.0 -3580000.0 -2.97 7195440.0 -2870888.3870968 -2.41407162902335 -5.0397 -0.9915 3089323 PK04_098310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P15 compound treatment 8527640.0 -328000.0 -0.28 8609000.0 -1190000.0 -0.99 8939440.0 -1126888.3870968 -0.947577515236416 -1.2813 -0.9159 2144225 PK04_098311 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P16 compound treatment 6580120.0 -2280000.0 -1.96 7583320.0 -2220000.0 -1.84 7592200.0 -2474128.3870968 -2.08044421813682 -3.3943 -0.9988 3000703 PK04_098312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P17 compound treatment 7340520.0 -1510000.0 -1.3 8453280.0 -1350000.0 -1.12 8431000.0 -1635328.3870968 -1.37511436570306 -2.1926 -0.9964 2141953 PK04_098313 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P18 compound treatment 6056000.0 -2800000.0 -2.41 6126840.0 -3680000.0 -3.05 6593560.0 -3472768.3870968 -2.92018027421032 -4.8372 -0.9951 3000704 PK04_098314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)c4cc5ccccc5[nH]4)[C@H]1OC(=O)c6cc7ccccc7[nH]6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P19 compound treatment 7926920.0 -928000.0 -0.8 8955200.0 -847000.0 -0.7 8592800.0 -1473528.3870968 -1.23906003794462 -1.5823 -0.9688 2143337 PK04_098315 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P20 compound treatment 3212520.0 -5640000.0 -4.86 3581360.0 -6220000.0 -5.16 3328880.0 -6737448.3870968 -5.66538325781005 -9.0542 -0.998 3089326 PK04_098316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P21 compound treatment 8418040.0 -437000.0 -0.38 8769160.0 -1030000.0 -0.86 8324280.0 -1742048.3870968 -1.46485304220727 -1.5577 -0.8961 2143233 PK04_098317 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P22 compound treatment 6673680.0 -2180000.0 -1.88 6949800.0 -2850000.0 -2.37 7693320.0 -2373008.3870968 -1.99541446768606 -3.6022 -0.995 3089328 PK04_098318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P23 compound treatment 7169760.0 -1690000.0 -1.45 7614520.0 -2190000.0 -1.81 7995480.0 -2070848.3870968 -1.74133427191664 -2.8906 -0.9956 2142969 PK04_098319 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2098 P24 compound treatment 7006520.0 -1850000.0 -1.59 7190960.0 -2610000.0 -2.17 7313360.0 -2752968.3870968 -2.31491510041225 -3.5057 -0.9883 3189006 PK04_098320 CC(C)[Si](OCCCNS(=O)(=O)c1ccc(Br)cc1)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A01 compound treatment 6407760.0 -3200000.0 -2.75 6446440.0 -4120000.0 -3.42 7174280.0 -3394310.0 -2.85420621294044 -5.2109 -0.9953 3052787 PK04_100001 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A02 compound treatment 7411480.0 -2200000.0 -1.89 7617480.0 -2950000.0 -2.45 8136920.0 -2431670.0 -2.04474182435337 -3.6839 -0.994 3052649 PK04_100002 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A03 compound treatment 7620000.0 -1990000.0 -1.71 8047320.0 -2520000.0 -2.09 8863000.0 -1705590.0 -1.43419592633822 -3.0219 -0.9884 3176622 PK04_100003 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A04 compound treatment 7691720.0 -1920000.0 -1.65 8293720.0 -2270000.0 -1.89 8588080.0 -1980510.0 -1.66537056037624 -3.0017 -0.9981 3175961 PK04_100004 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A05 compound treatment 7828520.0 -1780000.0 -1.53 8231120.0 -2330000.0 -1.94 8695400.0 -1873190.0 -1.57512735608059 -2.9116 -0.9942 3176556 PK04_100005 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A06 compound treatment 8161720.0 -1450000.0 -1.24 8552600.0 -2010000.0 -1.67 9146640.0 -1421950.0 -1.19568882173127 -2.373 -0.9881 3176630 PK04_100006 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A07 compound treatment 8168360.0 -1440000.0 -1.24 8745440.0 -1820000.0 -1.51 9257640.0 -1310950.0 -1.10235118031478 -2.2235 -0.9914 3175901 PK04_100007 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A08 compound treatment 8105680.0 -1500000.0 -1.29 8614560.0 -1950000.0 -1.62 8465560.0 -2103030.0 -1.76839513538838 -2.7019 -0.992 3176729 PK04_100008 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A09 compound treatment 8454080.0 -1150000.0 -0.99 9347440.0 -1220000.0 -1.01 9239400.0 -1329190.0 -1.11768882517457 -1.802 -0.9986 3052580 PK04_100009 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A10 compound treatment 8432320.0 -1180000.0 -1.01 8721320.0 -1840000.0 -1.53 9846600.0 -721990.0 -0.607106700236828 -1.818 -0.9409 3176731 PK04_100010 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A11 compound treatment 8300800.0 -1310000.0 -1.12 9221200.0 -1340000.0 -1.12 9245920.0 -1322670.0 -1.11220628984092 -1.9355 -1.0 3176633 PK04_100011 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A12 compound treatment 7663840.0 -1940000.0 -1.67 9401400.0 -1160000.0 -0.97 8957800.0 -1610790.0 -1.35448053529063 -2.3056 -0.9773 3176445 PK04_100012 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A13 mock treatment 7573720.0 -2030000.0 -1.75 9173680.0 -1390000.0 -1.16 9432120.0 -1136470.0 -0.955634498563898 -2.2291 -0.9673 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A14 mock treatment 8291040.0 -1320000.0 -1.13 9507160.0 -1060000.0 -0.88 9157480.0 -1411110.0 -1.18657368629924 -1.8463 -0.9921 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A15 compound treatment 8176600.0 -1430000.0 -1.23 9325680.0 -1240000.0 -1.03 8963240.0 -1605350.0 -1.34990614998157 -2.0844 -0.994 3175963 PK04_100013 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A16 compound treatment 8556360.0 -1050000.0 -0.9 8923200.0 -1640000.0 -1.36 9555520.0 -1013070.0 -0.851869949457643 -1.8009 -0.9765 3052785 PK04_100014 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A17 compound treatment 8037280.0 -1570000.0 -1.35 8936240.0 -1630000.0 -1.35 9683520.0 -885070.0 -0.744237353950345 -1.9905 -0.9703 3052837 PK04_100015 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A18 compound treatment 8012240.0 -1600000.0 -1.37 9117920.0 -1450000.0 -1.2 9039360.0 -1529230.0 -1.28589839084082 -2.2286 -0.9985 3176262 PK04_100016 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A19 compound treatment 8019160.0 -1590000.0 -1.37 8546040.0 -2020000.0 -1.68 9229960.0 -1338630.0 -1.12562672909324 -2.4066 -0.9871 3176686 PK04_100017 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A20 compound treatment 7610360.0 -2000000.0 -1.72 8664680.0 -1900000.0 -1.58 9441840.0 -1126750.0 -0.947461148342562 -2.45 -0.973 3176371 PK04_100018 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A21 compound treatment 7328160.0 -2280000.0 -1.96 8361760.0 -2200000.0 -1.83 9033840.0 -1534750.0 -1.29054004652207 -2.9334 -0.9856 3052829 PK04_100019 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A22 compound treatment 7930440.0 -1680000.0 -1.44 8210920.0 -2360000.0 -1.95 9495760.0 -1072830.0 -0.902120917485113 -2.4821 -0.9579 3052833 PK04_100020 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A23 compound treatment 7500800.0 -2110000.0 -1.81 7761600.0 -2800000.0 -2.33 8530280.0 -2038310.0 -1.713973404285 -3.3795 -0.9907 3052878 PK04_100021 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 A24 compound treatment 6334080.0 -3270000.0 -2.82 7088120.0 -3480000.0 -2.89 9238240.0 -1330350.0 -1.11866424557136 -3.9381 -0.9411 3052694 PK04_100022 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B01 compound treatment 7680080.0 -1930000.0 -1.66 9015240.0 -1550000.0 -1.29 8992800.0 -1575790.0 -1.3250497474566 -2.4655 -0.9932 3052928 PK04_100023 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B02 compound treatment 8484880.0 -1120000.0 -0.97 9407400.0 -1160000.0 -0.96 9463000.0 -1105590.0 -0.929668134897762 -1.6495 -0.9999 3052800 PK04_100024 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B03 compound treatment 8685960.0 -921000.0 -0.79 9930640.0 -635000.0 -0.53 9333080.0 -1235510.0 -1.03891521933767 -1.362 -0.9665 3052842 PK04_100025 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B04 compound treatment 8667280.0 -940000.0 -0.81 1.02856E7 -281000.0 -0.23 1.056144E7 -7150.0 -0.00601228951466547 -0.6049 -0.7185 3176782 PK04_100026 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B05 compound treatment 9045080.0 -562000.0 -0.48 9230760.0 -1340000.0 -1.11 9957960.0 -610630.0 -0.513466342145479 -1.2154 -0.9254 3175971 PK04_100027 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B06 compound treatment 9385560.0 -222000.0 -0.19 1.04682E7 -97900.0 -0.08 1.05632E7 -5390.0 -0.00453234132644012 -0.1597 -0.7697 3176561 PK04_100028 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B07 compound treatment 8921560.0 -686000.0 -0.59 1.029784E7 -268000.0 -0.22 1.035988E7 -208710.0 -0.175499992252564 -0.5706 -0.8714 3176369 PK04_100029 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B08 compound treatment 9354200.0 -253000.0 -0.22 1.079408E7 228000.0 0.19 1.04576E7 -110990.0 -0.0933292326199609 -0.0705 -0.2325 3176441 PK04_100030 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B09 compound treatment 9786240.0 179000.0 0.15 1.038252E7 -184000.0 -0.15 1.052048E7 -48110.0 -0.0404547200770008 -0.0224 -0.1017 3052641 PK04_100031 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B10 compound treatment 9237880.0 -369000.0 -0.32 1.065148E7 85400.0 0.07 1.051424E7 -54350.0 -0.0457018091079816 -0.1691 -0.514 3176555 PK04_100032 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B11 compound treatment 9062080.0 -545000.0 -0.47 1.074376E7 178000.0 0.15 1.056696E7 -1630.0 -0.00137063383341325 -0.1867 -0.3795 3176554 PK04_100033 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B12 compound treatment 9528880.0 -78500.0 -0.07 1.08332E7 267000.0 0.22 1.095156E7 382970.0 0.322031680479921 0.2748 0.6928 3052747 PK04_100034 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B13 mock treatment 9637760.0 30400.0 0.03 1.084516E7 279000.0 0.23 1.04096E7 -158990.0 -0.133691455935198 0.0716 0.2664 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B14 mock treatment 9056600.0 -551000.0 -0.47 1.041168E7 -154000.0 -0.13 1.145188E7 883290.0 0.742740588169072 0.0812 0.0912 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B15 compound treatment 8955760.0 -652000.0 -0.56 1.061876E7 52700.0 0.04 1.049056E7 -78030.0 -0.0656138392768317 -0.3364 -0.5941 3052707 PK04_100035 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B16 compound treatment 9362040.0 -245000.0 -0.21 1.06206E7 54500.0 0.05 1.059772E7 29130.0 0.0244948242744343 -0.0817 -0.3758 3176447 PK04_100036 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B17 compound treatment 8897440.0 -710000.0 -0.61 1.030468E7 -261000.0 -0.22 1.09728E7 404210.0 0.339891964296913 -0.2817 -0.3849 3176194 PK04_100037 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B18 compound treatment 9445800.0 -162000.0 -0.14 9979120.0 -587000.0 -0.49 1.13162E7 747610.0 0.628650036931336 0.0015 0.0019 3176504 PK04_100038 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B19 compound treatment 9440000.0 -167000.0 -0.14 1.005916E7 -507000.0 -0.42 1.054088E7 -27710.0 -0.0233007751680252 -0.3394 -0.7625 3176439 PK04_100039 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B20 compound treatment 8776920.0 -830000.0 -0.71 1.053592E7 -30200.0 -0.03 1.078508E7 216490.0 0.182042035948242 -0.322 -0.4363 3176678 PK04_100040 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B21 compound treatment 9219960.0 -387000.0 -0.33 9946960.0 -619000.0 -0.51 9876280.0 -692310.0 -0.582149392153574 -0.8252 -0.9766 3176260 PK04_100041 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B22 compound treatment 8857600.0 -750000.0 -0.65 1.022032E7 -346000.0 -0.29 1.031664E7 -251950.0 -0.211859628422373 -0.6605 -0.8959 3176621 PK04_100042 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B23 compound treatment 8607000.0 -1000000.0 -0.86 9570720.0 -995000.0 -0.83 9758440.0 -810150.0 -0.68123865039248 -1.3671 -0.9952 3176370 PK04_100043 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 B24 compound treatment 7301000.0 -2310000.0 -1.98 8812840.0 -1750000.0 -1.45 8963680.0 -1604910.0 -1.34953616293451 -2.7649 -0.9852 3176636 PK04_100044 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C01 compound treatment 7996720.0 -1610000.0 -1.39 8091040.0 -2480000.0 -2.05 9080720.0 -1487870.0 -1.25111960841753 -2.7081 -0.9758 3052532 PK04_100045 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C02 compound treatment 9006000.0 -601000.0 -0.52 9130440.0 -1440000.0 -1.19 9494880.0 -1073710.0 -0.902860891579226 -1.5077 -0.9533 3052638 PK04_100046 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C03 compound treatment 9056160.0 -551000.0 -0.47 9495080.0 -1070000.0 -0.89 9956160.0 -612430.0 -0.514979925519801 -1.0842 -0.9584 3052540 PK04_100047 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C04 compound treatment 9138320.0 -469000.0 -0.4 9831920.0 -734000.0 -0.61 1.030796E7 -260630.0 -0.219158463805211 -0.7112 -0.9323 3052751 PK04_100048 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C05 compound treatment 9235920.0 -371000.0 -0.32 9839720.0 -726000.0 -0.6 1.027868E7 -289910.0 -0.243779420027506 -0.6732 -0.9294 3052702 PK04_100049 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C06 compound treatment 9766640.0 159000.0 0.14 1.042772E7 -138000.0 -0.11 1.06568E7 88210.0 0.0741739941382715 0.0557 0.2876 3176680 PK04_100050 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C07 compound treatment 9724920.0 118000.0 0.1 1.11974E7 631000.0 0.52 1.099992E7 431330.0 0.362696620470022 0.5702 0.884 3052743 PK04_100051 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C08 compound treatment 9492040.0 -115000.0 -0.1 1.0431E7 -135000.0 -0.11 1.100936E7 440770.0 0.370634524388685 0.092 0.2301 3176043 PK04_100052 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C09 compound treatment 9867760.0 260000.0 0.22 9857960.0 -708000.0 -0.59 1.088228E7 313690.0 0.263775538161596 -0.0575 -0.0843 3052925 PK04_100053 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C10 compound treatment 9690760.0 83400.0 0.07 1.087492E7 309000.0 0.26 1.076544E7 196850.0 0.165527159575091 0.2849 0.9093 3176324 PK04_100054 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C11 mock treatment 9448280.0 -159000.0 -0.14 1.139224E7 826000.0 0.69 1.10212E7 452610.0 0.38059053947311 0.5364 0.674 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C12 mock treatment 9753720.0 146000.0 0.13 1.183516E7 1270000.0 1.05 1.126352E7 694930.0 0.584352496842864 1.0179 0.8408 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C13 compound treatment 9374280.0 -233000.0 -0.2 1.111592E7 550000.0 0.46 1.105E7 481410.0 0.404807873462252 0.3812 0.5938 3176376 PK04_100055 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C14 compound treatment 9840760.0 233000.0 0.2 1.09958E7 430000.0 0.36 1.122188E7 653290.0 0.549338268116896 0.6389 0.9328 3176324 PK04_100056 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C15 mock treatment 9365360.0 -242000.0 -0.21 1.02186E7 -348000.0 -0.29 1.087796E7 309370.0 0.260142938063225 -0.1365 -0.3098 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C16 mock treatment 9429520.0 -178000.0 -0.15 1.08036E7 237000.0 0.2 1.016224E7 -406350.0 -0.341691446753051 -0.1719 -0.4063 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C17 compound treatment 9702280.0 94900.0 0.08 1.09084E7 342000.0 0.28 1.080276E7 234170.0 0.196908788202687 0.3248 0.9147 3052884 PK04_100057 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C18 compound treatment 9719120.0 112000.0 0.1 1.121968E7 654000.0 0.54 1.065332E7 84730.0 0.0712477329479168 0.4097 0.7379 3176562 PK04_100058 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C19 compound treatment 9220600.0 -387000.0 -0.33 1.072812E7 162000.0 0.13 1.064772E7 79130.0 0.0665388068944725 -0.0762 -0.2086 3176124 PK04_100059 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C20 compound treatment 9388880.0 -218000.0 -0.19 1.05686E7 2490.0 0.0 1.087672E7 308130.0 0.259100247294248 0.0422 0.1319 3052784 PK04_100060 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C21 compound treatment 9017480.0 -590000.0 -0.51 9819320.0 -747000.0 -0.62 1.033256E7 -236030.0 -0.198472824356153 -0.7654 -0.9275 3052792 PK04_100061 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C22 compound treatment 8664960.0 -942000.0 -0.81 9496280.0 -1070000.0 -0.89 1.022484E7 -343750.0 -0.289052380512763 -1.1476 -0.928 3052749 PK04_100062 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C23 compound treatment 8612000.0 -995000.0 -0.86 9571920.0 -994000.0 -0.82 9443880.0 -1124710.0 -0.945745753851665 -1.5168 -0.9983 3176204 PK04_100063 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 C24 compound treatment 8523720.0 -1080000.0 -0.93 9177080.0 -1390000.0 -1.15 9111120.0 -1457470.0 -1.22555686698454 -1.9113 -0.9937 3176041 PK04_100064 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D01 compound treatment 8498880.0 -1110000.0 -0.95 9568080.0 -998000.0 -0.83 9761360.0 -807230.0 -0.67878328180747 -1.4207 -0.9907 3052926 PK04_100065 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D02 compound treatment 9179880.0 -427000.0 -0.37 1.06234E7 57300.0 0.05 1.052208E7 -46510.0 -0.0391093126331596 -0.2076 -0.5564 3176201 PK04_100066 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D03 compound treatment 9977440.0 370000.0 0.32 1.016948E7 -397000.0 -0.33 1.04898E7 -78790.0 -0.0662529078126563 -0.0443 -0.0958 3052885 PK04_100067 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D04 compound treatment 9277000.0 -330000.0 -0.28 1.046984E7 -96300.0 -0.08 1.10668E7 498210.0 0.418934651622585 0.0316 0.0617 3176377 PK04_100068 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D05 compound treatment 9315080.0 -292000.0 -0.25 1.063932E7 73200.0 0.06 1.020048E7 -368110.0 -0.309536208845246 -0.2889 -0.716 3052790 PK04_100069 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D06 compound treatment 9675560.0 68200.0 0.06 1.138776E7 822000.0 0.68 1.143632E7 867730.0 0.729656500777716 0.8487 0.8485 3052881 PK04_100070 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D07 compound treatment 9676040.0 68700.0 0.06 1.05648E7 -1310.0 0.0 1.08098E7 241210.0 0.202828580955589 0.1506 0.7128 3052536 PK04_100071 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D08 compound treatment 9894600.0 287000.0 0.25 1.088568E7 320000.0 0.27 1.075596E7 187370.0 0.157555620470331 0.3867 0.9785 3052923 PK04_100072 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D09 compound treatment 9742720.0 135000.0 0.12 1.147276E7 907000.0 0.75 1.138896E7 820370.0 0.689832440440016 0.8998 0.8759 3052690 PK04_100073 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D10 compound treatment 9476000.0 -131000.0 -0.11 1.021968E7 -346000.0 -0.29 1.087144E7 302850.0 0.254660402729572 -0.0842 -0.2103 3052841 PK04_100074 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D11 mock treatment 1.036248E7 755000.0 0.65 1.094916E7 383000.0 0.32 1.150088E7 932290.0 0.783943691136709 1.0113 0.948 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D12 mock treatment 9834400.0 227000.0 0.2 1.111536E7 549000.0 0.46 1.067692E7 108330.0 0.0910924927445749 0.4285 0.85 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D13 compound treatment 1.00482E7 441000.0 0.38 1.12972E7 731000.0 0.61 1.123952E7 670930.0 0.564171385185245 0.8949 0.9823 3176624 PK04_100075 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D14 compound treatment 9839200.0 232000.0 0.2 1.121148E7 645000.0 0.54 1.117456E7 605970.0 0.509547842965292 0.7185 0.9385 3176375 PK04_100076 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D15 mock treatment 9852120.0 245000.0 0.21 1.040776E7 -158000.0 -0.13 1.058452E7 15930.0 0.0133952128627442 0.0535 0.2152 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D16 mock treatment 1.030532E7 698000.0 0.6 1.115696E7 591000.0 0.49 1.06414E7 72810.0 0.0612244474912997 0.6651 0.8553 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D17 compound treatment 9642120.0 34700.0 0.03 1.125656E7 690000.0 0.57 1.078436E7 215770.0 0.181436602598513 0.4527 0.7525 3176503 PK04_100077 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D18 compound treatment 9961920.0 355000.0 0.31 1.137872E7 813000.0 0.67 1.05402E7 -28390.0 -0.0238725733316577 0.5516 0.745 3052543 PK04_100078 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D19 compound treatment 9495240.0 -112000.0 -0.1 1.058124E7 15100.0 0.01 1.110344E7 534850.0 0.449744482086549 0.2112 0.4589 3052538 PK04_100079 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D20 compound treatment 9306320.0 -301000.0 -0.26 1.13054E7 739000.0 0.61 1.11124E7 543810.0 0.45727876377206 0.4685 0.58 3052705 PK04_100080 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D21 compound treatment 9035680.0 -572000.0 -0.49 9860840.0 -705000.0 -0.59 1.0365E7 -203590.0 -0.171194688432272 -0.7207 -0.92 3052691 PK04_100081 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D22 compound treatment 9290480.0 -317000.0 -0.27 1.048108E7 -85000.0 -0.07 1.01462E7 -422390.0 -0.355179156377559 -0.4033 -0.8895 3052534 PK04_100082 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D23 compound treatment 9100240.0 -507000.0 -0.44 1.080452E7 238000.0 0.2 1.068972E7 121130.0 0.101855752295305 -0.079 -0.1613 3176202 PK04_100083 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 D24 compound treatment 8316520.0 -1290000.0 -1.11 9172560.0 -1390000.0 -1.16 1.002708E7 -541510.0 -0.455344740571538 -1.5718 -0.943 3176197 PK04_100084 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E01 mock treatment 9005720.0 -602000.0 -0.52 9166320.0 -1400000.0 -1.16 9871680.0 -696910.0 -0.586017438554617 -1.3077 -0.9341 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E02 mock treatment 9051640.0 -556000.0 -0.48 1.011432E7 -452000.0 -0.37 1.057316E7 4570.0 0.0038428200114715 -0.4903 -0.8069 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E03 compound treatment 9035960.0 -571000.0 -0.49 1.007332E7 -493000.0 -0.41 1.06744E7 105810.0 0.088973476020525 -0.4686 -0.7257 3176672 PK04_100085 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E04 compound treatment 9644320.0 36900.0 0.03 1.064516E7 79100.0 0.07 1.02208E7 -347790.0 -0.292449534308462 -0.1126 -0.3737 3052883 PK04_100086 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E05 compound treatment 9954640.0 347000.0 0.3 9780120.0 -786000.0 -0.65 1.07916E7 223010.0 0.187524571281895 -0.0956 -0.129 3176126 PK04_100087 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E06 compound treatment 9835400.0 228000.0 0.2 1.049992E7 -66200.0 -0.05 1.085552E7 286930.0 0.241273598663352 0.2209 0.6995 3052533 PK04_100088 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E07 compound treatment 9914680.0 307000.0 0.26 1.088472E7 319000.0 0.26 1.186436E7 1295770.0 1.08958662719134 0.9344 0.8111 3175839 PK04_100089 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E08 compound treatment 9814920.0 208000.0 0.18 1.133E7 764000.0 0.63 1.145092E7 882330.0 0.741933343702767 0.8973 0.9046 3052695 PK04_100090 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E09 mock treatment 9683280.0 75900.0 0.07 1.083416E7 268000.0 0.22 1.192232E7 1353730.0 1.13832401184449 0.8233 0.7087 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E10 mock treatment 1.023736E7 630000.0 0.54 1.06882E7 122000.0 0.1 1.11566E7 588010.0 0.494445644408174 0.657 0.8869 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E11 compound treatment 1.001616E7 409000.0 0.35 1.140456E7 838000.0 0.7 1.092592E7 357330.0 0.300471526192365 0.7782 0.9315 3176568 PK04_100091 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E12 compound treatment 9982640.0 375000.0 0.32 1.20862E7 1520000.0 1.26 1.142524E7 856650.0 0.720339554229115 1.3304 0.8942 3176044 PK04_100092 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E13 compound treatment 1.120048E7 1590000.0 1.37 1.164616E7 1080000.0 0.9 1.156904E7 1000450.0 0.841258048244345 1.7946 0.9746 3052753 PK04_100093 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E14 compound treatment 9750960.0 144000.0 0.12 1.148352E7 917000.0 0.76 1.079588E7 227290.0 0.19112353619417 0.6211 0.7819 3175962 PK04_100094 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E15 compound treatment 9748040.0 141000.0 0.12 1.113696E7 571000.0 0.47 1.132964E7 761050.0 0.639951459459602 0.7128 0.8851 3176325 PK04_100095 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E16 compound treatment 1.003216E7 425000.0 0.37 1.094632E7 380000.0 0.32 1.065016E7 81570.0 0.0685905532463304 0.4328 0.8874 3052542 PK04_100096 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E17 mock treatment 9787280.0 180000.0 0.15 1.10748E7 509000.0 0.42 1.108492E7 516330.0 0.434171390924087 0.5837 0.934 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E18 mock treatment 9669840.0 62500.0 0.05 1.054676E7 -19300.0 -0.02 1.054188E7 -26710.0 -0.0224598955156244 0.0088 0.1456 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E19 compound treatment 9422120.0 -185000.0 -0.16 1.071572E7 150000.0 0.12 1.099272E7 424130.0 0.356642286972737 0.1855 0.4526 3052746 PK04_100097 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E20 compound treatment 9490120.0 -117000.0 -0.1 1.064448E7 78400.0 0.07 1.018284E7 -385750.0 -0.324369325913595 -0.208 -0.6014 3176676 PK04_100098 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E21 compound treatment 9437600.0 -170000.0 -0.15 1.070816E7 142000.0 0.12 1.090104E7 332450.0 0.279550440440634 0.1451 0.4308 3052756 PK04_100099 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E22 compound treatment 8904720.0 -703000.0 -0.6 1.04034E7 -163000.0 -0.13 1.095812E7 389530.0 0.32754785099967 -0.238 -0.3395 3176560 PK04_100100 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E23 compound treatment 9864840.0 257000.0 0.22 1.003728E7 -529000.0 -0.44 1.010288E7 -465710.0 -0.39160606291956 -0.3514 -0.5593 3052487 PK04_100101 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 E24 compound treatment 9035760.0 -572000.0 -0.49 9320240.0 -1250000.0 -1.03 9483720.0 -1084870.0 -0.912245108500018 -1.4074 -0.9616 3176563 PK04_100102 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F01 mock treatment 8588520.0 -1020000.0 -0.88 8498960.0 -2070000.0 -1.71 9261360.0 -1307230.0 -1.09922310800785 -2.131 -0.9609 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F02 mock treatment 8799600.0 -808000.0 -0.7 1.002528E7 -541000.0 -0.45 1.055932E7 -9270.0 -0.00779495437775509 -0.6649 -0.8036 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F03 compound treatment 9599320.0 -8060.0 -0.01 1.022304E7 -343000.0 -0.28 1.033148E7 -237110.0 -0.199380974380745 -0.2834 -0.8155 3176684 PK04_100103 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F04 compound treatment 9715320.0 108000.0 0.09 1.08024E7 236000.0 0.2 1.027908E7 -289510.0 -0.243443068166546 0.0263 0.0805 3176121 PK04_100104 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F05 compound treatment 9186720.0 -421000.0 -0.36 1.0814E7 248000.0 0.21 1.069488E7 126290.0 0.106194691301693 -0.029 -0.0674 3176435 PK04_100105 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F06 compound treatment 1.015408E7 547000.0 0.47 1.08828E7 317000.0 0.26 1.097748E7 408890.0 0.343827281070149 0.6218 0.9728 3176627 PK04_100106 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F07 compound treatment 9931800.0 324000.0 0.28 1.06568E7 90700.0 0.08 1.077768E7 209090.0 0.175819526520476 0.3061 0.9046 3176774 PK04_100107 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F08 compound treatment 1.022732E7 620000.0 0.53 1.139236E7 826000.0 0.69 1.114848E7 579890.0 0.48761770163068 0.9853 0.9891 3174822 PK04_100108 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F09 mock treatment 9875720.0 268000.0 0.23 1.055876E7 -7350.0 -0.01 1.085228E7 283690.0 0.238549148589573 0.2675 0.8057 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F10 mock treatment 1.007244E7 465000.0 0.4 1.056308E7 -3030.0 0.0 1.172824E7 1159650.0 0.975126088906547 0.7926 0.752 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F11 compound treatment 1.03002E7 693000.0 0.6 1.131672E7 751000.0 0.62 1.155612E7 987530.0 0.830393883135328 1.1832 0.9885 3176192 PK04_100109 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F12 compound treatment 1.010952E7 502000.0 0.43 1.157164E7 1010000.0 0.83 1.13076E7 739010.0 0.621418471920689 1.0899 0.9676 3052594 PK04_100110 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F13 compound treatment 9736120.0 129000.0 0.11 1.108592E7 520000.0 0.43 1.219332E7 1624730.0 1.3662023976451 1.1017 0.7667 3052748 PK04_100111 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F14 compound treatment 1.009516E7 488000.0 0.42 1.12288E7 663000.0 0.55 1.140032E7 831730.0 0.699384833291288 0.9636 0.9796 3176567 PK04_100112 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F15 compound treatment 9400360.0 -207000.0 -0.18 1.055388E7 -12200.0 -0.01 1.115592E7 587330.0 0.493873846244541 0.1764 0.3359 3052759 PK04_100113 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F16 compound treatment 1.015048E7 543000.0 0.47 1.12748E7 709000.0 0.59 1.158492E7 1016330.0 0.85461121712447 1.1027 0.9692 3176780 PK04_100114 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F17 mock treatment 1.026744E7 660000.0 0.57 1.173652E7 1170000.0 0.97 1.119088E7 622290.0 0.523270998892472 1.1907 0.9597 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F18 mock treatment 1.01946E7 587000.0 0.51 1.083724E7 271000.0 0.22 1.1173E7 604410.0 0.508236070707547 0.7151 0.9519 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F19 compound treatment 9246960.0 -360000.0 -0.31 1.121308E7 647000.0 0.54 1.144948E7 880890.0 0.74072247700331 0.5584 0.5782 3176625 PK04_100115 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F20 compound treatment 9819520.0 212000.0 0.18 1.076E7 194000.0 0.16 1.077724E7 208650.0 0.17544953947342 0.2996 0.9986 3052750 PK04_100116 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F21 compound treatment 9228920.0 -378000.0 -0.33 1.081492E7 249000.0 0.21 1.088676E7 318170.0 0.267542679004351 0.0856 0.1823 3052889 PK04_100117 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F22 compound treatment 9651040.0 43700.0 0.04 1.06232E7 57100.0 0.05 1.137856E7 809970.0 0.681087292055048 0.4423 0.6468 3052696 PK04_100118 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F23 compound treatment 9126040.0 -481000.0 -0.41 9976200.0 -590000.0 -0.49 1.057592E7 7330.0 0.00616364785209761 -0.5182 -0.8081 3176674 PK04_100119 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 F24 compound treatment 8514120.0 -1090000.0 -0.94 9241240.0 -1320000.0 -1.1 9798160.0 -770430.0 -0.647838910599121 -1.5518 -0.9789 3176436 PK04_100120 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G01 compound treatment 7872760.0 -1730000.0 -1.49 8742200.0 -1820000.0 -1.51 9450800.0 -1117790.0 -0.939926866657051 -2.2781 -0.9802 3052845 PK04_100121 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G02 compound treatment 9361640.0 -246000.0 -0.21 9751120.0 -815000.0 -0.68 9879240.0 -689350.0 -0.579660388382467 -0.8471 -0.9255 3052835 PK04_100122 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G03 mock treatment 9919520.0 312000.0 0.27 9843000.0 -723000.0 -0.6 1.071136E7 142770.0 0.120052387973257 -0.1219 -0.1825 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G04 mock treatment 9616240.0 8860.0 0.01 1.062312E7 57000.0 0.05 1.03974E7 -171190.0 -0.143950187694487 -0.0514 -0.3388 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G05 compound treatment 9733600.0 126000.0 0.11 1.09748E7 409000.0 0.34 1.067396E7 105370.0 0.0886034889734686 0.3096 0.8439 3176502 PK04_100123 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G06 compound treatment 9346280.0 -261000.0 -0.22 1.065936E7 93300.0 0.08 1.092772E7 359130.0 0.301985109566687 0.0893 0.2323 3176265 PK04_100124 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G07 compound treatment 9984920.0 378000.0 0.32 1.077016E7 204000.0 0.17 1.100528E7 436690.0 0.36720373540689 0.4973 0.9588 3052742 PK04_100125 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G08 compound treatment 9730680.0 123000.0 0.11 1.032556E7 -241000.0 -0.2 1.149716E7 928570.0 0.780815618829779 0.3969 0.4882 3052639 PK04_100126 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G09 compound treatment 1.023432E7 627000.0 0.54 1.114236E7 576000.0 0.48 1.22796E7 1711010.0 1.43875349405423 1.4182 0.8813 3176200 PK04_100127 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G10 compound treatment 1.03058E7 698000.0 0.6 1.147724E7 911000.0 0.76 1.143012E7 861530.0 0.724443046932831 1.2017 0.9954 3052650 PK04_100128 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G11 compound treatment 9737960.0 131000.0 0.11 1.129344E7 727000.0 0.6 1.158208E7 1013490.0 0.852223118911651 0.9053 0.862 3176683 PK04_100129 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G12 compound treatment 1.021512E7 608000.0 0.52 1.10172E7 451000.0 0.37 1.134984E7 781250.0 0.656937228438098 0.8973 0.976 3176631 PK04_100130 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G13 compound treatment 1.022528E7 618000.0 0.53 1.20184E7 1450000.0 1.2 1.104768E7 479090.0 0.402857032668683 1.2352 0.8969 3176045 PK04_100131 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G14 compound treatment 9819360.0 212000.0 0.18 1.145196E7 886000.0 0.73 1.109688E7 528290.0 0.4442283115668 0.7861 0.8954 3176196 PK04_100132 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G15 compound treatment 9774400.0 167000.0 0.14 1.101964E7 454000.0 0.38 1.105028E7 481690.0 0.405043319764925 0.5341 0.935 3176446 PK04_100133 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G16 compound treatment 1.048672E7 879000.0 0.76 1.073384E7 168000.0 0.14 1.103852E7 469930.0 0.395154575052692 0.7454 0.8617 3052834 PK04_100134 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G17 compound treatment 9500000.0 -107000.0 -0.09 1.11344E7 568000.0 0.47 1.104076E7 472170.0 0.397038145474069 0.4481 0.7189 3052640 PK04_100135 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G18 compound treatment 9997960.0 391000.0 0.34 1.098148E7 415000.0 0.34 1.097668E7 408090.0 0.343154577348228 0.5911 0.9999 3176727 PK04_100136 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G19 mock treatment 9796160.0 189000.0 0.16 1.073864E7 173000.0 0.14 1.045692E7 -111670.0 -0.0939010307835935 0.1222 0.5179 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G20 mock treatment 9358440.0 -249000.0 -0.21 1.150012E7 934000.0 0.77 1.101952E7 450930.0 0.379177861657077 0.5426 0.6104 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G21 compound treatment 9476600.0 -131000.0 -0.11 1.091452E7 348000.0 0.29 1.053052E7 -38070.0 -0.0320122883668971 0.0834 0.2675 3176272 PK04_100137 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G22 compound treatment 9139240.0 -468000.0 -0.4 1.086184E7 296000.0 0.25 1.075724E7 188650.0 0.158631946425404 6.0E-4 0.0012 3176261 PK04_100138 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G23 compound treatment 9184880.0 -422000.0 -0.36 1.015444E7 -412000.0 -0.34 1.072484E7 156250.0 0.13138744568762 -0.3312 -0.6421 3176513 PK04_100139 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 G24 compound treatment 8786560.0 -821000.0 -0.71 9634440.0 -932000.0 -0.77 9479440.0 -1089150.0 -0.915844073412293 -1.3828 -0.9941 3052924 PK04_100140 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H01 compound treatment 7896720.0 -1710000.0 -1.47 9134560.0 -1430000.0 -1.19 9831720.0 -736870.0 -0.619618989464552 -1.8934 -0.9512 3176557 PK04_100141 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H02 compound treatment 9824160.0 217000.0 0.19 1.018832E7 -378000.0 -0.31 1.136676E7 798170.0 0.671164912156719 0.3143 0.4114 3052875 PK04_100142 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H03 mock treatment 9432680.0 -175000.0 -0.15 1.042224E7 -144000.0 -0.12 1.001104E7 -557550.0 -0.468832450196047 -0.4264 -0.8417 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H04 mock treatment 9861640.0 254000.0 0.22 1.095096E7 385000.0 0.32 1.039848E7 -170110.0 -0.143042037669894 0.2281 0.5527 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H05 compound treatment 9762880.0 156000.0 0.13 1.076436E7 198000.0 0.16 1.043644E7 -132150.0 -0.111122246064761 0.1081 0.4514 3052652 PK04_100143 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H06 compound treatment 1.067388E7 1070000.0 0.92 1.026244E7 -304000.0 -0.25 1.093556E7 366970.0 0.308577606041509 0.5626 0.5623 3052786 PK04_100144 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H07 compound treatment 9581400.0 -26000.0 -0.02 1.054696E7 -19100.0 -0.02 1.084324E7 274650.0 0.23094759653187 0.1113 0.4784 3176328 PK04_100145 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H08 compound treatment 9584680.0 -22700.0 -0.02 1.100232E7 436000.0 0.36 1.095784E7 389250.0 0.327312404696998 0.3866 0.7917 3176321 PK04_100146 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H09 compound treatment 9993000.0 386000.0 0.33 1.058612E7 20000.0 0.02 1.109436E7 525770.0 0.44210929484275 0.4564 0.8253 3176735 PK04_100147 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H10 compound treatment 1.010084E7 493000.0 0.42 1.089084E7 325000.0 0.27 1.130232E7 733730.0 0.616978627356013 0.7569 0.9509 3175969 PK04_100148 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H11 compound treatment 9689360.0 82000.0 0.07 1.04492E7 -117000.0 -0.1 1.114376E7 575170.0 0.483648749671348 0.264 0.5298 3176193 PK04_100149 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H12 compound treatment 1.085696E7 1250000.0 1.08 1.141208E7 846000.0 0.7 1.19962E7 1427610.0 1.20044820056386 1.7192 0.978 3176050 PK04_100150 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H13 compound treatment 9703960.0 96600.0 0.08 1.113864E7 573000.0 0.47 1.166196E7 1093370.0 0.919392585545425 0.853 0.8217 3176569 PK04_100151 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H14 compound treatment 1.009192E7 485000.0 0.42 1.112388E7 558000.0 0.46 1.226072E7 1692130.0 1.42287768621691 1.3294 0.8559 3052874 PK04_100152 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H15 compound treatment 9662680.0 55300.0 0.05 1.123256E7 666000.0 0.55 1.109412E7 525530.0 0.441907483726174 0.6018 0.8484 3052832 PK04_100153 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H16 compound treatment 1.010932E7 502000.0 0.43 1.160632E7 1040000.0 0.86 1.130068E7 732090.0 0.615599584726076 1.103 0.9636 3176267 PK04_100154 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H17 compound treatment 9832880.0 226000.0 0.19 1.180272E7 1240000.0 1.03 1.136128E7 792690.0 0.666556891661563 1.0892 0.8793 3176378 PK04_100155 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H18 compound treatment 9873320.0 266000.0 0.23 1.17288E7 1160000.0 0.96 1.137852E7 809930.0 0.681053656868952 1.0822 0.8998 3176322 PK04_100156 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H19 mock treatment 9930800.0 323000.0 0.28 1.130748E7 741000.0 0.62 1.074908E7 180490.0 0.151770368461814 0.6034 0.8721 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H20 mock treatment 9841240.0 234000.0 0.2 1.098412E7 418000.0 0.35 1.126576E7 697170.0 0.586236067264241 0.6549 0.9221 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H21 compound treatment 9860840.0 253000.0 0.22 1.114432E7 578000.0 0.48 1.036088E7 -207710.0 -0.174659112600163 0.302 0.5441 3052801 PK04_100157 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H22 compound treatment 9915040.0 308000.0 0.26 1.122364E7 658000.0 0.55 1.02704E7 -298190.0 -0.250741903549384 0.323 0.4923 3176726 PK04_100158 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H23 compound treatment 9421640.0 -186000.0 -0.16 1.09946E7 428000.0 0.36 1.045804E7 -110550.0 -0.0929592455729046 0.0593 0.1479 3176558 PK04_100159 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 H24 compound treatment 1.044556E7 838000.0 0.72 9646400.0 -920000.0 -0.76 9402200.0 -1166390.0 -0.980793617763729 -0.5903 -0.4108 3052704 PK04_100160 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I01 compound treatment 8716120.0 -891000.0 -0.77 8697040.0 -1870000.0 -1.55 8705920.0 -1862670.0 -1.56628130213733 -2.2423 -0.9609 3052648 PK04_100161 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I02 compound treatment 9621160.0 13800.0 0.01 8913480.0 -1650000.0 -1.37 1.015416E7 -414430.0 -0.348485754344449 -0.9859 -0.6969 3176506 PK04_100162 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I03 compound treatment 9236360.0 -371000.0 -0.32 1.01916E7 -375000.0 -0.31 9961960.0 -606630.0 -0.510102823535876 -0.6582 -0.9719 3176274 PK04_100163 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I04 compound treatment 9602320.0 -5060.0 0.0 1.068616E7 120000.0 0.1 1.054676E7 -21830.0 -0.0183564028119087 0.0444 0.4379 3176679 PK04_100164 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I05 mock treatment 9351720.0 -256000.0 -0.22 1.026732E7 -299000.0 -0.25 1.007044E7 -498150.0 -0.418884198843441 -0.512 -0.9585 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I06 mock treatment 1.03852E7 778000.0 0.67 1.087148E7 305000.0 0.25 1.056416E7 -4430.0 -0.00372509686013539 0.5306 0.7413 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I07 compound treatment 1.011808E7 511000.0 0.44 1.12802E7 714000.0 0.59 1.048336E7 -85230.0 -0.0716681727741172 0.5544 0.7481 3052930 PK04_100165 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I08 compound treatment 9923280.0 316000.0 0.27 1.088592E7 320000.0 0.27 1.091784E7 349250.0 0.293677218600967 0.4797 0.999 3176444 PK04_100166 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I09 compound treatment 1.008552E7 478000.0 0.41 1.065224E7 86100.0 0.07 1.066372E7 95130.0 0.0799928813328848 0.325 0.7643 3052697 PK04_100167 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I10 compound treatment 9935560.0 328000.0 0.28 1.035204E7 -214000.0 -0.18 1.12944E7 725810.0 0.610318860508999 0.4129 0.5936 3176731 PK04_100168 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I11 compound treatment 1.024376E7 636000.0 0.55 9966680.0 -599000.0 -0.5 1.102832E7 459730.0 0.386577602598204 0.2523 0.3023 3052535 PK04_100169 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I12 compound treatment 1.035104E7 744000.0 0.64 1.171984E7 1150000.0 0.96 1.15398E7 971210.0 0.816670727208147 1.3936 0.9873 3176198 PK04_100170 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I13 compound treatment 1.108156E7 1470000.0 1.27 1.112872E7 563000.0 0.47 1.105172E7 483130.0 0.406254186464382 1.2365 0.876 3176119 PK04_100171 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I14 compound treatment 9612480.0 5100.0 0.0 1.135436E7 788000.0 0.65 1.150872E7 940130.0 0.790536187611531 0.8365 0.8153 3176442 PK04_100172 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I15 compound treatment 1.02396E7 632000.0 0.54 1.136684E7 801000.0 0.66 1.14362E7 867610.0 0.729555595219428 1.1189 0.993 3176566 PK04_100173 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I16 compound treatment 9791200.0 184000.0 0.16 1.093468E7 369000.0 0.31 1.141236E7 843770.0 0.709509024306194 0.6775 0.8591 3052844 PK04_100174 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I17 compound treatment 9873160.0 266000.0 0.23 1.121776E7 652000.0 0.54 1.098252E7 413930.0 0.348065314518249 0.6451 0.9453 3176781 PK04_100175 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I18 compound treatment 1.022652E7 619000.0 0.53 1.077196E7 206000.0 0.17 1.133316E7 764570.0 0.642911355836053 0.7774 0.9121 3052891 PK04_100176 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I19 compound treatment 9972720.0 365000.0 0.31 1.099632E7 430000.0 0.36 1.042856E7 -140030.0 -0.117748377725679 0.3196 0.6523 3052840 PK04_100177 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I20 compound treatment 9789960.0 183000.0 0.16 1.100012E7 434000.0 0.36 1.098924E7 420650.0 0.353716025782382 0.5028 0.9512 3174821 PK04_100178 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I21 mock treatment 9171320.0 -436000.0 -0.38 9908400.0 -658000.0 -0.55 1.030864E7 -259950.0 -0.218586665641579 -0.6579 -0.9434 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I22 mock treatment 9205320.0 -402000.0 -0.35 1.135244E7 786000.0 0.65 1.077664E7 208050.0 0.174945011681979 0.2778 0.3661 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I23 compound treatment 9480320.0 -127000.0 -0.11 1.033024E7 -236000.0 -0.2 1.052552E7 -43070.0 -0.036216686628901 -0.197 -0.8677 3176670 PK04_100179 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 I24 compound treatment 8561480.0 -1050000.0 -0.9 9440680.0 -1130000.0 -0.93 1.015912E7 -409470.0 -0.344314991268541 -1.2575 -0.9372 3176728 PK04_100180 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J01 compound treatment 8785160.0 -822000.0 -0.71 9635600.0 -931000.0 -0.77 9532160.0 -1036430.0 -0.871512898137725 -1.3574 -0.9963 3176783 PK04_100181 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J02 compound treatment 9291160.0 -316000.0 -0.27 9469480.0 -1100000.0 -0.91 9557560.0 -1011030.0 -0.850154554966746 -1.1732 -0.9205 3176448 PK04_100182 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J03 compound treatment 9235720.0 -372000.0 -0.32 1.03386E7 -228000.0 -0.19 1.043216E7 -136430.0 -0.114721210977036 -0.3599 -0.9258 3176047 PK04_100183 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J04 compound treatment 9560440.0 -46900.0 -0.04 1.086192E7 296000.0 0.25 1.009844E7 -470150.0 -0.39533956857622 -0.1099 -0.2353 3176269 PK04_100184 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J05 mock treatment 9622360.0 15000.0 0.01 1.005068E7 -515000.0 -0.43 1.079368E7 225090.0 0.189273600958888 -0.1301 -0.2782 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J06 mock treatment 9138720.0 -469000.0 -0.4 1.070764E7 142000.0 0.12 1.047416E7 -94430.0 -0.0794042655762043 -0.2109 -0.4934 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J07 compound treatment 9133240.0 -474000.0 -0.41 1.025112E7 -315000.0 -0.26 1.076076E7 192170.0 0.161591842801855 -0.2932 -0.5739 3176635 PK04_100185 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J08 compound treatment 9709200.0 102000.0 0.09 1.074084E7 175000.0 0.14 1.046632E7 -102270.0 -0.0859967620510263 0.0846 0.4455 3176114 PK04_100186 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J09 compound treatment 9902120.0 295000.0 0.25 1.059268E7 26600.0 0.02 1.014064E7 -427950.0 -0.359854447244907 -0.0486 -0.1102 3175966 PK04_100187 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J10 compound treatment 1.02518E7 644000.0 0.55 1.02306E7 -336000.0 -0.28 1.083396E7 265370.0 0.223144233357591 0.2883 0.4373 3052757 PK04_100188 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J11 compound treatment 1.02544E7 647000.0 0.56 1.041768E7 -148000.0 -0.12 1.039228E7 -176310.0 -0.148255491514779 0.1648 0.2797 3174819 PK04_100189 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J12 compound treatment 9402920.0 -204000.0 -0.18 1.110452E7 538000.0 0.45 1.106548E7 496890.0 0.417824690481416 0.3975 0.6246 3176738 PK04_100190 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J13 compound treatment 9775760.0 168000.0 0.14 1.137704E7 811000.0 0.67 1.11836E7 615010.0 0.517149395022995 0.7706 0.8952 3176380 PK04_100191 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J14 compound treatment 1.062256E7 1020000.0 0.87 1.167916E7 1110000.0 0.92 1.086804E7 299450.0 0.251801411911409 1.1829 0.9128 3176199 PK04_100192 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J15 compound treatment 9773520.0 166000.0 0.14 1.08028E7 237000.0 0.2 1.091696E7 348370.0 0.292937244506855 0.365 0.9593 3176623 PK04_100193 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J16 compound treatment 9695080.0 87700.0 0.08 1.091732E7 351000.0 0.29 1.111916E7 550570.0 0.462963110222289 0.4791 0.8676 3176632 PK04_100194 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J17 compound treatment 9955480.0 348000.0 0.3 1.110852E7 542000.0 0.45 1.121784E7 649250.0 0.545941114321197 0.748 0.9735 3052795 PK04_100195 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J18 compound treatment 9291440.0 -316000.0 -0.27 1.109876E7 533000.0 0.44 1.069464E7 126050.0 0.105992880185116 0.1593 0.3009 3052636 PK04_100196 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J19 compound treatment 9917160.0 310000.0 0.27 1.06862E7 120000.0 0.1 1.067168E7 103090.0 0.0866862833659949 0.2615 0.8789 3052591 PK04_100197 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J20 compound treatment 9151640.0 -456000.0 -0.39 1.1309E7 743000.0 0.62 1.055952E7 -9070.0 -0.00762677844727494 0.125 0.171 3176629 PK04_100198 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J21 mock treatment 9329840.0 -278000.0 -0.24 1.07712E7 205000.0 0.17 1.051748E7 -51110.0 -0.0429773590342031 -0.0645 -0.2176 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J22 mock treatment 9100640.0 -507000.0 -0.44 1.047584E7 -90300.0 -0.07 1.049404E7 -74550.0 -0.062687578086477 -0.3312 -0.7411 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J23 compound treatment 9376440.0 -231000.0 -0.2 1.056716E7 1050.0 0.0 1.0054E7 -514590.0 -0.43270826032891 -0.3641 -0.7646 3176776 PK04_100199 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 J24 compound treatment 8559440.0 -1050000.0 -0.9 9479200.0 -1090000.0 -0.9 8836920.0 -1731670.0 -1.45612606767283 -1.882 -0.9723 3052544 PK04_100200 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K01 compound treatment 8470160.0 -1140000.0 -0.98 8374200.0 -2190000.0 -1.82 9564920.0 -1003670.0 -0.843965680725076 -2.1022 -0.9423 3176739 PK04_100201 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K02 compound treatment 8729920.0 -877000.0 -0.76 9786000.0 -780000.0 -0.65 9706280.0 -862310.0 -0.725098933061704 -1.2283 -0.9979 3176042 PK04_100202 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K03 compound treatment 8966880.0 -640000.0 -0.55 1.09376E7 371000.0 0.31 9905760.0 -662830.0 -0.557360260000799 -0.4621 -0.5486 3052528 PK04_100203 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K04 compound treatment 9833200.0 226000.0 0.19 1.054488E7 -21200.0 -0.02 1.04064E7 -162190.0 -0.13638227082288 0.0233 0.0979 3176564 PK04_100204 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K05 compound treatment 9701800.0 94400.0 0.08 9923280.0 -643000.0 -0.53 1.075092E7 182330.0 0.153317587022232 -0.1725 -0.3075 3176329 PK04_100205 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K06 compound treatment 9902640.0 295000.0 0.25 1.089928E7 333000.0 0.28 1.05434E7 -25190.0 -0.0211817584439753 0.2941 0.782 3052588 PK04_100206 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K07 mock treatment 9563600.0 -43800.0 -0.04 1.067688E7 111000.0 0.09 1.113464E7 566050.0 0.475979927241453 0.3061 0.6296 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K08 mock treatment 1.018232E7 575000.0 0.49 1.094128E7 375000.0 0.31 1.05836E7 15010.0 0.0126216035825355 0.4727 0.8084 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K09 compound treatment 9266600.0 -341000.0 -0.29 1.07682E7 202000.0 0.17 1.018868E7 -379910.0 -0.319458588743575 -0.257 -0.5527 3176733 PK04_100207 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K10 compound treatment 9728920.0 122000.0 0.1 1.049032E7 -75800.0 -0.06 1.116792E7 599330.0 0.503964402073351 0.3151 0.6076 3052589 PK04_100208 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K11 compound treatment 9657280.0 49900.0 0.04 1.052108E7 -45000.0 -0.04 1.0781E7 212410.0 0.178611246966447 0.1063 0.5673 3052651 PK04_100209 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K12 compound treatment 9994320.0 387000.0 0.33 1.093792E7 372000.0 0.31 1.17848E7 1216210.0 1.02268624204633 0.9608 0.8587 3176507 PK04_100210 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K13 compound treatment 1.0045E7 438000.0 0.38 1.130164E7 736000.0 0.61 1.125596E7 687370.0 0.577995446670714 0.9034 0.9809 3052706 PK04_100211 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K14 compound treatment 1.013384E7 526000.0 0.45 1.125752E7 691000.0 0.57 1.127684E7 708250.0 0.595553013812842 0.9366 0.9934 3175959 PK04_100212 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K15 mock treatment 1.013624E7 529000.0 0.46 1.058488E7 18800.0 0.02 1.082048E7 251890.0 0.211809175643229 0.3941 0.7846 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K16 mock treatment 9998840.0 391000.0 0.34 1.090172E7 336000.0 0.28 1.114308E7 574490.0 0.483076951507716 0.6342 0.9735 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K17 compound treatment 9474360.0 -133000.0 -0.11 1.046332E7 -103000.0 -0.09 1.024624E7 -322350.0 -0.271057555951387 -0.2718 -0.8873 3174817 PK04_100213 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K18 compound treatment 9601520.0 -5860.0 -0.01 1.095448E7 388000.0 0.32 1.09444E7 375810.0 0.316010982168732 0.3655 0.81 3176725 PK04_100214 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K19 compound treatment 9710200.0 103000.0 0.09 1.066464E7 98500.0 0.08 1.021524E7 -353350.0 -0.29712482517581 -0.0733 -0.2285 3052537 PK04_100215 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K20 compound treatment 9221560.0 -386000.0 -0.33 1.051388E7 -52200.0 -0.04 1.083716E7 268570.0 0.225835048245274 -0.0863 -0.2138 3052596 PK04_100216 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K21 compound treatment 9256600.0 -351000.0 -0.3 1.039868E7 -167000.0 -0.14 1.0751E7 182410.0 0.153384857394424 -0.1659 -0.4534 3176049 PK04_100217 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K22 compound treatment 9499000.0 -108000.0 -0.09 1.063564E7 69500.0 0.06 9993560.0 -575030.0 -0.483531026520012 -0.2997 -0.6045 3052637 PK04_100218 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K23 mock treatment 9268920.0 -338000.0 -0.29 1.04344E7 -132000.0 -0.11 9710360.0 -858230.0 -0.721668144079909 -0.6479 -0.8245 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 K24 mock treatment 8958480.0 -649000.0 -0.56 9733080.0 -833000.0 -0.69 8956880.0 -1611710.0 -1.35525414457084 -1.5039 -0.928 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L01 compound treatment 8801600.0 -806000.0 -0.69 8820440.0 -1750000.0 -1.45 9279600.0 -1288990.0 -1.08388546314806 -1.8623 -0.9613 3052595 PK04_100219 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L02 compound treatment 9493560.0 -114000.0 -0.1 1.03898E7 -176000.0 -0.15 1.104476E7 476170.0 0.400401664083672 0.0902 0.2062 3176046 PK04_100220 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L03 compound treatment 9598880.0 -8500.0 -0.01 9810120.0 -756000.0 -0.63 1.012356E7 -445030.0 -0.374216671707913 -0.5824 -0.7974 3052585 PK04_100221 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L04 compound treatment 9670360.0 63000.0 0.05 1.027564E7 -290000.0 -0.24 1.071484E7 146250.0 0.122978649163612 -0.0368 -0.1335 3176734 PK04_100222 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L05 compound treatment 9820880.0 214000.0 0.18 1.083524E7 269000.0 0.22 1.020296E7 -365630.0 -0.307450827307292 0.0575 0.1362 3176688 PK04_100223 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L06 compound treatment 1.067656E7 1070000.0 0.92 1.083168E7 266000.0 0.22 1.11378E7 569210.0 0.47863710694304 0.9348 0.8816 3176372 PK04_100224 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L07 mock treatment 9671640.0 64300.0 0.06 1.0311E7 -255000.0 -0.21 1.031272E7 -255870.0 -0.215155876659784 -0.2145 -0.699 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L08 mock treatment 9938840.0 331000.0 0.29 1.06236E7 57500.0 0.05 1.099568E7 427090.0 0.359131290743843 0.3996 0.8665 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L09 compound treatment 9790520.0 183000.0 0.16 1.096296E7 397000.0 0.33 1.131024E7 741650.0 0.623638394203027 0.6411 0.8873 3176559 PK04_100225 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L10 compound treatment 1.011452E7 507000.0 0.44 1.04348E7 -131000.0 -0.11 1.122408E7 655490.0 0.551188203352178 0.5073 0.7131 3052527 PK04_100226 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L11 compound treatment 9567400.0 -40000.0 -0.03 1.113416E7 568000.0 0.47 1.190232E7 1333730.0 1.12150641879647 0.8997 0.7393 3176432 PK04_100227 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L12 compound treatment 1.015552E7 548000.0 0.47 1.074216E7 176000.0 0.15 1.139476E7 826170.0 0.69470954242394 0.7578 0.889 3176326 PK04_100228 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L13 compound treatment 9895480.0 288000.0 0.25 1.075584E7 190000.0 0.16 1.114156E7 572970.0 0.481798814436066 0.5122 0.9077 3176737 PK04_100229 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L14 compound treatment 9489200.0 -118000.0 -0.1 1.111968E7 554000.0 0.46 1.10486E7 480010.0 0.403630641948891 0.4394 0.709 3175964 PK04_100230 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L15 mock treatment 9682400.0 75000.0 0.06 1.102376E7 458000.0 0.38 1.042964E7 -138950.0 -0.116840227701086 0.189 0.4697 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L16 mock treatment 9168600.0 -439000.0 -0.38 1.104444E7 478000.0 0.4 1.11356E7 567010.0 0.476787171707758 0.2863 0.3943 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L17 compound treatment 9524520.0 -82900.0 -0.07 1.18196E7 1250000.0 1.04 1.093116E7 362570.0 0.304877735570945 0.7352 0.677 3176787 PK04_100231 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L18 compound treatment 9420840.0 -187000.0 -0.16 1.098544E7 419000.0 0.35 1.132164E7 753050.0 0.633224422240396 0.4737 0.6401 3175960 PK04_100232 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L19 compound treatment 9777480.0 170000.0 0.15 1.073492E7 169000.0 0.14 1.09892E7 420610.0 0.353682390596286 0.3696 0.9067 3176273 PK04_100233 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L20 compound treatment 9876400.0 269000.0 0.23 1.08526E7 286000.0 0.24 1.086848E7 299890.0 0.252171398958465 0.4165 0.9994 3052882 PK04_100234 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L21 compound treatment 9522520.0 -84900.0 -0.07 1.022152E7 -345000.0 -0.29 1.06656E7 97010.0 0.0815737350793982 -0.1601 -0.523 3176053 PK04_100235 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L22 compound treatment 9331400.0 -276000.0 -0.24 1.024232E7 -324000.0 -0.27 1.01856E7 -382990.0 -0.322048498072969 -0.4781 -0.9921 3052696 PK04_100236 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L23 mock treatment 8953480.0 -654000.0 -0.56 9922960.0 -643000.0 -0.53 1.023648E7 -332110.0 -0.279264541358818 -0.7942 -0.9635 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 L24 mock treatment 9363840.0 -244000.0 -0.21 1.004744E7 -519000.0 -0.43 9332240.0 -1236350.0 -1.03962155824569 -0.9697 -0.8472 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M01 compound treatment 8756000.0 -851000.0 -0.73 8538000.0 -2030000.0 -1.68 9306600.0 -1261990.0 -1.06118171253324 -2.0071 -0.9468 3176052 PK04_100237 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M02 compound treatment 9016920.0 -590000.0 -0.51 9920360.0 -646000.0 -0.54 9681960.0 -886630.0 -0.74554912620809 -1.0331 -0.9846 3176323 PK04_100238 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M03 compound treatment 8796720.0 -811000.0 -0.7 9678720.0 -887000.0 -0.74 1.009336E7 -475230.0 -0.399611237210416 -1.0585 -0.971 3176206 PK04_100239 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M04 compound treatment 8741600.0 -866000.0 -0.75 9986000.0 -580000.0 -0.48 1.026828E7 -300310.0 -0.252524568412474 -0.8538 -0.9258 3052883 PK04_100240 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M05 compound treatment 9061880.0 -545000.0 -0.47 1.013248E7 -434000.0 -0.36 1.005824E7 -510350.0 -0.429142930602731 -0.7265 -0.9942 3052744 PK04_100241 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M06 compound treatment 9311400.0 -296000.0 -0.25 1.103084E7 465000.0 0.39 1.054084E7 -27750.0 -0.0233344103541212 0.062 0.1341 3176505 PK04_100242 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M07 compound treatment 9585120.0 -22300.0 -0.02 1.04676E7 -98500.0 -0.08 1.0528E7 -40590.0 -0.0341313050909471 -0.0779 -0.8603 3176434 PK04_100243 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M08 compound treatment 9412000.0 -195000.0 -0.17 1.020836E7 -358000.0 -0.3 1.063132E7 62730.0 0.0527483805951 -0.238 -0.6895 3176729 PK04_100244 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M09 mock treatment 1.00636E7 456000.0 0.39 1.035516E7 -211000.0 -0.17 1.036052E7 -208070.0 -0.174961829275027 0.0246 0.0531 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M10 mock treatment 1.001784E7 410000.0 0.35 1.084528E7 279000.0 0.23 1.092392E7 355330.0 0.298789766887564 0.5102 0.986 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M11 compound treatment 9740760.0 133000.0 0.11 1.093196E7 366000.0 0.3 1.063816E7 69570.0 0.0584999974175212 0.2753 0.8349 3052590 PK04_100245 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M12 compound treatment 9891400.0 284000.0 0.24 1.064572E7 79600.0 0.07 1.052896E7 -39630.0 -0.0333240606246423 0.16 0.6266 3176565 PK04_100246 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M13 mock treatment 1.007608E7 469000.0 0.4 1.152652E7 960000.0 0.8 1.114868E7 580090.0 0.48778587756116 0.9745 0.9577 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M14 mock treatment 9972280.0 365000.0 0.31 1.07998E7 234000.0 0.19 1.101184E7 443250.0 0.372719905926639 0.5084 0.9693 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M15 compound treatment 9688320.0 80900.0 0.07 1.047224E7 -93900.0 -0.08 1.048756E7 -81030.0 -0.068136478234034 -0.0441 -0.3534 3176508 PK04_100247 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M16 compound treatment 1.028728E7 680000.0 0.59 1.10894E7 523000.0 0.43 1.065764E7 89050.0 0.0748803330462881 0.6317 0.8625 3052587 PK04_100248 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M17 compound treatment 1.01218E7 514000.0 0.44 1.057712E7 11000.0 0.01 1.066428E7 95690.0 0.0804637739382292 0.3073 0.6829 3052643 PK04_100249 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M18 compound treatment 9164920.0 -442000.0 -0.38 1.034136E7 -225000.0 -0.19 1.042104E7 -147550.0 -0.124071792711733 -0.3991 -0.9035 3176777 PK04_100250 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M19 compound treatment 8882560.0 -725000.0 -0.62 9837120.0 -729000.0 -0.6 1.04198E7 -148790.0 -0.12511448348071 -0.7815 -0.8904 3052583 PK04_100251 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M20 compound treatment 9448920.0 -158000.0 -0.14 9799480.0 -767000.0 -0.64 9999280.0 -569310.0 -0.47872119490828 -0.7223 -0.8944 3052586 PK04_100252 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M21 compound treatment 9076440.0 -531000.0 -0.46 1.000532E7 -561000.0 -0.47 1.028884E7 -279750.0 -0.235236082759114 -0.6682 -0.9639 3052593 PK04_100253 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M22 compound treatment 9083920.0 -523000.0 -0.45 1.01028E7 -463000.0 -0.38 9714800.0 -853790.0 -0.717934638423249 -0.8965 -0.9633 3176374 PK04_100254 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M23 compound treatment 9012280.0 -595000.0 -0.51 1.002056E7 -546000.0 -0.45 9400400.0 -1168190.0 -0.98230720113805 -1.1241 -0.9394 3052699 PK04_100255 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 M24 compound treatment 9294360.0 -313000.0 -0.27 9118280.0 -1450000.0 -1.2 9350600.0 -1217990.0 -1.02418300782761 -1.4403 -0.8995 3176628 PK04_100256 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N01 compound treatment 8302640.0 -1300000.0 -1.12 8938000.0 -1630000.0 -1.35 9186400.0 -1382190.0 -1.16225544675181 -2.0991 -0.9967 3052530 PK04_100257 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N02 compound treatment 8745400.0 -862000.0 -0.74 9795840.0 -770000.0 -0.64 9941040.0 -627550.0 -0.5276940258641 -1.1019 -0.9907 3176510 PK04_100258 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N03 compound treatment 9219160.0 -388000.0 -0.33 1.017588E7 -390000.0 -0.32 9846000.0 -722590.0 -0.607611228028269 -0.7306 -0.9547 3052646 PK04_100259 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N04 compound treatment 9578360.0 -29000.0 -0.02 1.030112E7 -265000.0 -0.22 1.034768E7 -220910.0 -0.185758724011853 -0.2486 -0.8605 3176040 PK04_100260 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N05 compound treatment 8610160.0 -997000.0 -0.86 1.028564E7 -280000.0 -0.23 9436680.0 -1131910.0 -0.95180008734895 -1.1794 -0.9054 3052838 PK04_100261 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N06 compound treatment 9842920.0 236000.0 0.2 1.034792E7 -218000.0 -0.18 1.02912E7 -277390.0 -0.233251606779448 -0.1221 -0.341 3176263 PK04_100262 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N07 compound treatment 9740520.0 133000.0 0.11 1.008948E7 -477000.0 -0.4 1.030212E7 -266470.0 -0.224069200975232 -0.2915 -0.6219 3176511 PK04_100263 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N08 compound treatment 9091960.0 -515000.0 -0.44 9929400.0 -637000.0 -0.53 9959440.0 -609150.0 -0.512221840259926 -0.8568 -0.9973 3052644 PK04_100264 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N09 mock treatment 9395600.0 -212000.0 -0.18 1.055776E7 -8350.0 -0.01 9835320.0 -733270.0 -0.616591822715909 -0.4652 -0.7235 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N10 mock treatment 9512920.0 -94500.0 -0.08 9893360.0 -673000.0 -0.56 1.0698E7 129410.0 0.108818235817183 -0.3063 -0.5333 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N11 compound treatment 9746120.0 139000.0 0.12 1.054788E7 -18200.0 -0.02 1.01512E7 -417390.0 -0.350974758115555 -0.1424 -0.3839 3052880 PK04_100265 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N12 compound treatment 1.03894E7 782000.0 0.67 1.11018E7 536000.0 0.44 1.091564E7 347050.0 0.291827283365686 0.8136 0.9486 3176732 PK04_100266 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N13 mock treatment 1.021568E7 608000.0 0.52 9946400.0 -620000.0 -0.51 1.042088E7 -147710.0 -0.124206333456117 -0.0663 -0.089 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N14 mock treatment 9195280.0 -412000.0 -0.35 1.06906E7 124000.0 0.1 1.016952E7 -399070.0 -0.335569842883573 -0.3389 -0.679 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N15 compound treatment 9365120.0 -242000.0 -0.21 1.042912E7 -137000.0 -0.11 1.066684E7 98250.0 0.0826164258483752 -0.1383 -0.55 3052703 PK04_100267 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N16 compound treatment 9282800.0 -325000.0 -0.28 1.018648E7 -380000.0 -0.31 1.05212E7 -47390.0 -0.0398492867272723 -0.3661 -0.8658 3176120 PK04_100268 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N17 compound treatment 9126120.0 -481000.0 -0.41 1.058724E7 21100.0 0.02 1.007032E7 -498270.0 -0.418985104401729 -0.4709 -0.799 3052843 PK04_100269 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N18 compound treatment 9174800.0 -433000.0 -0.37 9968760.0 -597000.0 -0.5 1.055948E7 -9110.0 -0.00766041363337097 -0.5055 -0.8155 3176116 PK04_100270 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N19 compound treatment 9345960.0 -261000.0 -0.22 9691040.0 -875000.0 -0.73 1.009852E7 -470070.0 -0.395272298204028 -0.7772 -0.9073 3176319 PK04_100271 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N20 compound treatment 8967720.0 -640000.0 -0.55 1.001184E7 -554000.0 -0.46 1.017252E7 -396070.0 -0.333047203926371 -0.7756 -0.9807 3052797 PK04_100272 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N21 compound treatment 9219000.0 -388000.0 -0.33 1.000888E7 -557000.0 -0.46 1.012012E7 -448470.0 -0.377109297712171 -0.6776 -0.9909 3052581 PK04_100273 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N22 compound treatment 8843680.0 -764000.0 -0.66 9631080.0 -935000.0 -0.78 9312240.0 -1256350.0 -1.0564391512937 -1.4372 -0.9803 3176118 PK04_100274 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N23 compound treatment 8940120.0 -667000.0 -0.57 9924560.0 -642000.0 -0.53 9110960.0 -1457630.0 -1.22569140772893 -1.3465 -0.9258 3176207 PK04_100275 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 N24 compound treatment 1.174916E7 2140000.0 1.84 8962800.0 -1600000.0 -1.33 8586920.0 -1981670.0 -1.66634598077302 -0.6657 -0.2362 3176266 PK04_100276 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O01 compound treatment 8117000.0 -1490000.0 -1.28 7844680.0 -2720000.0 -2.26 8749240.0 -1819350.0 -1.52985439559533 -2.9273 -0.9713 3176687 PK04_100277 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O02 compound treatment 8559800.0 -1050000.0 -0.9 9588080.0 -978000.0 -0.81 9938440.0 -630150.0 -0.529880312960342 -1.2949 -0.9783 3176323 PK04_100278 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O03 compound treatment 8822720.0 -785000.0 -0.68 9463520.0 -1100000.0 -0.91 9983520.0 -585070.0 -0.491973458230116 -1.202 -0.9703 3176438 PK04_100279 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O04 compound treatment 8584400.0 -1020000.0 -0.88 9361920.0 -1200000.0 -1.0 9576240.0 -992350.0 -0.834446923059899 -1.5668 -0.9971 3176117 PK04_100280 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O05 compound treatment 8985520.0 -622000.0 -0.54 1.008472E7 -481000.0 -0.4 9611440.0 -957150.0 -0.804847959295392 -1.0042 -0.9603 3176384 PK04_100281 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O06 compound treatment 9101560.0 -506000.0 -0.44 1.034696E7 -219000.0 -0.18 1.027568E7 -292910.0 -0.246302058984708 -0.4985 -0.9367 3052695 PK04_100282 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O07 compound treatment 9424960.0 -182000.0 -0.16 1.06208E7 54700.0 0.05 1.0355E7 -213590.0 -0.179603484956279 -0.1681 -0.6924 3052929 PK04_100283 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O08 compound treatment 9207320.0 -400000.0 -0.34 1.035804E7 -208000.0 -0.17 1.0128E7 -440590.0 -0.370483166051253 -0.5123 -0.9587 3052798 PK04_100284 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O09 compound treatment 9197440.0 -410000.0 -0.35 1.038656E7 -180000.0 -0.15 1.041912E7 -149470.0 -0.125686281644342 -0.3623 -0.8988 3176509 PK04_100285 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O10 compound treatment 9888240.0 281000.0 0.24 1.0709E7 143000.0 0.12 1.076312E7 194530.0 0.163576318781521 0.3024 0.9601 3176681 PK04_100286 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O11 mock treatment 9595800.0 -11600.0 -0.01 1.055584E7 -10300.0 -0.01 1.07146E7 146010.0 0.122776838047036 0.0602 0.4877 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O12 mock treatment 1.011856E7 511000.0 0.44 1.0892E7 326000.0 0.27 1.07108E7 142210.0 0.119581495367913 0.4791 0.904 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O13 compound treatment 1.012524E7 518000.0 0.45 1.056836E7 2250.0 0.0 1.049052E7 -78070.0 -0.0656474744629277 0.2205 0.4894 3176682 PK04_100287 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O14 compound treatment 9515000.0 -92400.0 -0.08 1.117244E7 606000.0 0.5 1.029932E7 -269270.0 -0.226423664001954 0.1138 0.2042 3176320 PK04_100288 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O15 compound treatment 9552160.0 -55200.0 -0.05 1.082012E7 254000.0 0.21 1.044416E7 -124430.0 -0.104630655148227 0.0338 0.1409 3176268 PK04_100289 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O16 compound treatment 9316720.0 -291000.0 -0.25 1.10356E7 469000.0 0.39 1.061284E7 44250.0 0.0372089246187339 0.1019 0.2195 3176373 PK04_100290 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O17 compound treatment 9805760.0 198000.0 0.17 1.120452E7 638000.0 0.53 1.045596E7 -112630.0 -0.0947082752498982 0.3497 0.6195 3052700 PK04_100291 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O18 compound treatment 9097080.0 -510000.0 -0.44 1.052416E7 -41900.0 -0.03 1.011008E7 -458510.0 -0.385551729422275 -0.4963 -0.8477 3176275 PK04_100292 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O19 compound treatment 9074800.0 -533000.0 -0.46 9911560.0 -655000.0 -0.54 9878480.0 -690110.0 -0.580299456918292 -0.9132 -0.9954 3052887 PK04_100293 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O20 compound treatment 9213920.0 -393000.0 -0.34 1.013636E7 -430000.0 -0.36 1.028836E7 -280230.0 -0.235639704992266 -0.5374 -0.9856 3176039 PK04_100294 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O21 compound treatment 9168360.0 -439000.0 -0.38 1.0317E7 -249000.0 -0.21 9843280.0 -725310.0 -0.609898420682799 -0.6896 -0.9236 3176637 PK04_100295 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O22 compound treatment 8386640.0 -1220000.0 -1.05 9792520.0 -774000.0 -0.64 9103880.0 -1464710.0 -1.23164483566792 -1.6882 -0.9694 3176115 PK04_100296 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O23 compound treatment 9110920.0 -496000.0 -0.43 9725600.0 -841000.0 -0.7 9538920.0 -1029670.0 -0.865828551687496 -1.1491 -0.9649 3052755 PK04_100297 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 O24 compound treatment 7857360.0 -1750000.0 -1.51 9082720.0 -1480000.0 -1.23 8423800.0 -2144790.0 -1.80351026967264 -2.6213 -0.9883 3176443 PK04_100298 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P01 compound treatment 7483480.0 -2120000.0 -1.83 7612280.0 -2950000.0 -2.45 7438080.0 -3130510.0 -2.63238216063712 -3.9899 -0.989 3052698 PK04_100299 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P02 compound treatment 8223320.0 -1380000.0 -1.19 9054360.0 -1510000.0 -1.25 8664000.0 -1904590.0 -1.60153097716597 -2.3364 -0.9912 3176634 PK04_100300 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P03 compound treatment 9345840.0 -262000.0 -0.23 8462320.0 -2100000.0 -1.75 9477560.0 -1091030.0 -0.917424927158807 -1.6672 -0.8401 3174820 PK04_100301 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P04 compound treatment 9463440.0 -144000.0 -0.12 8789240.0 -1780000.0 -1.47 8981680.0 -1586910.0 -1.3344003291913 -1.693 -0.8498 3052597 PK04_100302 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P05 compound treatment 8846120.0 -761000.0 -0.66 9595760.0 -970000.0 -0.8 1.369944E7 3130850.0 2.63266805971894 0.677 0.2392 3176270 PK04_100303 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P06 compound treatment 1.303288E7 3430000.0 2.95 9186600.0 -1380000.0 -1.14 1.428548E7 3716890.0 3.12545717121188 2.8459 0.6401 3176677 PK04_100304 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P07 compound treatment 9021880.0 -585000.0 -0.5 9201360.0 -1360000.0 -1.13 1.328792E7 2719330.0 2.28662926516297 0.3756 0.1444 3176122 PK04_100305 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P08 compound treatment 8897360.0 -710000.0 -0.61 9156920.0 -1410000.0 -1.17 1.230356E7 1734970.0 1.45890097052576 -0.1854 -0.0943 3052701 PK04_100306 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P09 compound treatment 8813720.0 -794000.0 -0.68 9010320.0 -1560000.0 -1.29 1.113828E7 569690.0 0.479040729176192 -0.8629 -0.5615 3175972 PK04_100307 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P10 compound treatment 9831080.0 224000.0 0.19 9203560.0 -1360000.0 -1.13 9858360.0 -710230.0 -0.597217955524595 -0.8862 -0.6855 3052830 PK04_100308 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P11 mock treatment 1.165596E7 2050000.0 1.76 9240440.0 -1330000.0 -1.1 9894600.0 -673990.0 -0.566744476921592 0.0558 0.0259 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P12 mock treatment 8974800.0 -633000.0 -0.54 9379680.0 -1190000.0 -0.98 9605520.0 -963070.0 -0.809825966837605 -1.3501 -0.9741 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P13 compound treatment 8217920.0 -1390000.0 -1.2 8613760.0 -1950000.0 -1.62 9369400.0 -1199190.0 -1.00837447036247 -2.2077 -0.9805 3052541 PK04_100309 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P14 compound treatment 9421280.0 -186000.0 -0.16 9325520.0 -1240000.0 -1.03 9326360.0 -1242230.0 -1.0445659306018 -1.2897 -0.8743 3052545 PK04_100310 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P15 compound treatment 1.129048E7 1680000.0 1.45 9629920.0 -936000.0 -0.78 9697640.0 -870950.0 -0.732364133258446 -0.0349 -0.0194 3176381 PK04_100311 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P16 compound treatment 1.176216E7 2150000.0 1.85 9294920.0 -1270000.0 -1.05 9201640.0 -1366950.0 -1.14944044084923 -0.2018 -0.0833 3052789 PK04_100312 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P17 compound treatment 8643360.0 -964000.0 -0.83 9059240.0 -1510000.0 -1.25 9130120.0 -1438470.0 -1.20958015358893 -1.8991 -0.9854 3052890 PK04_100313 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P18 compound treatment 8777000.0 -830000.0 -0.71 9293800.0 -1270000.0 -1.06 9637120.0 -931470.0 -0.783254169821741 -1.4742 -0.9854 3176779 PK04_100314 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P19 compound treatment 7966840.0 -1640000.0 -1.41 8849680.0 -1720000.0 -1.42 8898440.0 -1670150.0 -1.40439515145714 -2.4481 -1.0 3052876 PK04_100315 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P20 compound treatment 8456200.0 -1150000.0 -0.99 8994320.0 -1570000.0 -1.3 9240160.0 -1328430.0 -1.11704975663875 -1.9698 -0.9937 3176264 PK04_100316 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P21 compound treatment 9434880.0 -172000.0 -0.15 8949360.0 -1620000.0 -1.34 9065720.0 -1502870.0 -1.26373280320354 -1.5897 -0.8599 3052692 PK04_100317 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P22 compound treatment 7871040.0 -1740000.0 -1.49 8477520.0 -2090000.0 -1.73 8930760.0 -1637830.0 -1.37721792109155 -2.6582 -0.9954 3176051 PK04_100318 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P23 compound treatment 8964920.0 -642000.0 -0.55 8635120.0 -1930000.0 -1.6 8624080.0 -1944510.0 -1.63509889288981 -2.1881 -0.9292 3052754 PK04_100319 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2100 P24 compound treatment 7069000.0 -2540000.0 -2.18 6934080.0 -3630000.0 -3.01 7260320.0 -3308270.0 -2.78185692764788 -4.607 -0.9915 3176127 PK04_100320 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A01 compound treatment 6885520.0 -2280000.0 -1.96 7689960.0 -2520000.0 -2.09 7130800.0 -2775342.5 -2.33372903669307 -3.6868 -0.9974 3189007 PK04_101001 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A02 compound treatment 8039120.0 -1130000.0 -0.97 8298600.0 -1910000.0 -1.59 7414760.0 -2491382.5 -2.09495285059735 -2.6842 -0.9586 3069619 PK04_101002 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A03 compound treatment 8423640.0 -742000.0 -0.64 8817280.0 -1390000.0 -1.15 8033200.0 -1872942.5 -1.57491923836662 -1.9445 -0.9464 3189008 PK04_101003 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A04 compound treatment 8587240.0 -578000.0 -0.5 8874920.0 -1330000.0 -1.11 8595080.0 -1311062.5 -1.10244577927568 -1.5628 -0.9532 3189009 PK04_101004 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A05 compound treatment 8557720.0 -607000.0 -0.52 8880520.0 -1330000.0 -1.1 8288120.0 -1618022.5 -1.36056219737662 -1.7238 -0.9433 3069620 PK04_101005 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A06 compound treatment 8364440.0 -801000.0 -0.69 9862440.0 -347000.0 -0.29 8181480.0 -1724662.5 -1.45023360350863 -1.4013 -0.8591 3189010 PK04_101006 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A07 compound treatment 8909360.0 -256000.0 -0.22 9850800.0 -359000.0 -0.3 8607160.0 -1298982.5 -1.09228795307468 -0.9295 -0.8059 3189011 PK04_101007 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A08 compound treatment 8720640.0 -445000.0 -0.38 9020560.0 -1190000.0 -0.99 8563760.0 -1342382.5 -1.12878212998887 -1.442 -0.9321 3069621 PK04_101008 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A09 compound treatment 9057600.0 -108000.0 -0.09 9328000.0 -881000.0 -0.73 8414760.0 -1491382.5 -1.25407319819658 -1.1996 -0.8247 3189120 PK04_101009 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A10 compound treatment 9248760.0 83600.0 0.07 9272480.0 -937000.0 -0.78 8859040.0 -1047102.5 -0.880487186227972 -0.9155 -0.7781 3069622 PK04_101010 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A11 compound treatment 8087880.0 -1080000.0 -0.93 9269240.0 -940000.0 -0.78 8942760.0 -963382.5 -0.81008874172898 -1.4533 -0.9971 3189121 PK04_101011 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A12 compound treatment 8606800.0 -558000.0 -0.48 9673640.0 -536000.0 -0.44 8790560.0 -1115582.5 -0.938070624824377 -1.0756 -0.9403 3069678 PK04_101012 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A13 mock treatment 8672200.0 -493000.0 -0.42 9669400.0 -540000.0 -0.45 8497120.0 -1409022.5 -1.18481835002486 -1.1876 -0.8891 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A14 mock treatment 9039320.0 -126000.0 -0.11 9214040.0 -995000.0 -0.83 8791720.0 -1114422.5 -0.937095204427592 -1.0803 -0.8617 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A15 compound treatment 8971200.0 -194000.0 -0.17 9812760.0 -397000.0 -0.33 8976960.0 -929182.5 -0.781330657616874 -0.7374 -0.8535 3189122 PK04_101013 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A16 compound treatment 9020720.0 -144000.0 -0.12 9131720.0 -1080000.0 -0.89 8724000.0 -1182142.5 -0.994039574488172 -1.1618 -0.8653 3069679 PK04_101014 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A17 compound treatment 8581480.0 -584000.0 -0.5 9692640.0 -517000.0 -0.43 9027800.0 -878342.5 -0.738580336088819 -0.9639 -0.9729 3189123 PK04_101015 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A18 compound treatment 8332120.0 -833000.0 -0.72 9549560.0 -660000.0 -0.55 8538040.0 -1368102.5 -1.15040955464862 -1.3941 -0.9537 3189124 PK04_101016 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A19 compound treatment 8375840.0 -789000.0 -0.68 8781400.0 -1430000.0 -1.18 8146360.0 -1759782.5 -1.47976529690095 -1.9305 -0.9587 3069680 PK04_101017 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A20 compound treatment 8008520.0 -1160000.0 -1.0 9330920.0 -878000.0 -0.73 8253920.0 -1652222.5 -1.38932028148872 -1.7976 -0.9675 3189125 PK04_101018 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A21 compound treatment 8396120.0 -769000.0 -0.66 8928280.0 -1280000.0 -1.06 8446400.0 -1459742.5 -1.22746776599462 -1.7044 -0.9721 3069681 PK04_101019 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A22 compound treatment 7933840.0 -1230000.0 -1.06 8874200.0 -1340000.0 -1.11 8051280.0 -1854862.5 -1.55971613425121 -2.1518 -0.984 3189126 PK04_101020 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A23 compound treatment 8056560.0 -1110000.0 -0.95 8774160.0 -1440000.0 -1.19 8003680.0 -1902462.5 -1.59974200570549 -2.1619 -0.9779 3189127 PK04_101021 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 A24 compound treatment 7166000.0 -2000000.0 -1.72 7891000.0 -2320000.0 -1.92 7910720.0 -1995422.5 -1.67791017819267 -3.0725 -0.9982 3069682 PK04_101022 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B01 compound treatment 8276800.0 -888000.0 -0.76 8991560.0 -1220000.0 -1.01 8752440.0 -1153702.5 -0.970124957173894 -1.5848 -0.9932 3189128 PK04_101023 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B02 compound treatment 8578240.0 -587000.0 -0.51 9532760.0 -677000.0 -0.56 9267160.0 -638982.5 -0.537307382490172 -0.9259 -0.9991 3189129 PK04_101024 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B03 compound treatment 9500840.0 336000.0 0.29 9661520.0 -548000.0 -0.45 9130120.0 -776022.5 -0.652541530055173 -0.4723 -0.5583 3069683 PK04_101025 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B04 compound treatment 9177960.0 12800.0 0.01 1.003804E7 -171000.0 -0.14 9143840.0 -762302.5 -0.641004661224234 -0.4458 -0.6789 3189130 PK04_101026 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B05 compound treatment 8602200.0 -563000.0 -0.48 1.020568E7 -3630.0 0.0 9209600.0 -696542.5 -0.58570841528236 -0.6197 -0.8152 3069684 PK04_101027 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B06 compound treatment 8752600.0 -413000.0 -0.36 9999960.0 -209000.0 -0.17 9558440.0 -347702.5 -0.292375957338877 -0.4741 -0.9642 3189131 PK04_101028 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5c(Cl)cccc5CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B07 compound treatment 9019440.0 -146000.0 -0.13 1.048332E7 274000.0 0.23 1.052012E7 613977.5 0.516281186781891 0.3569 0.6176 3189132 PK04_101029 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B08 compound treatment 9067200.0 -98000.0 -0.08 1.041076E7 201000.0 0.17 1.007812E7 171977.5 0.144612380420753 0.1313 0.555 3069685 PK04_101030 OCc1cccc(Cl)c1N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B09 compound treatment 9384280.0 219000.0 0.19 1.06184E7 409000.0 0.34 1.019636E7 290217.5 0.244037990520619 0.4457 0.9719 3189133 PK04_101031 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B10 compound treatment 9226960.0 61800.0 0.05 1.039288E7 184000.0 0.15 9748000.0 -158142.5 -0.132978810429788 0.0418 0.2001 3189129 PK04_101032 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B11 compound treatment 8904320.0 -261000.0 -0.22 1.04774E7 268000.0 0.22 1.01506E7 244457.5 0.20555933762676 0.1174 0.3115 3189134 PK04_101033 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B12 compound treatment 9355280.0 190000.0 0.16 1.035544E7 146000.0 0.12 9942200.0 36057.5 0.0303200180664406 0.1819 0.8838 3069686 PK04_101034 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B13 mock treatment 8974320.0 -191000.0 -0.16 1.067696E7 468000.0 0.39 9412760.0 -493382.5 -0.414875305100621 -0.1104 -0.1867 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B14 mock treatment 9378240.0 213000.0 0.18 1.073264E7 523000.0 0.43 1.015744E7 251297.5 0.211310954449181 0.4785 0.9265 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B15 compound treatment 9247760.0 82600.0 0.07 1.012528E7 -84000.0 -0.07 1.022084E7 314697.5 0.26462272441139 0.1536 0.5431 3189135 PK04_101035 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B16 compound treatment 9139400.0 -25800.0 -0.02 1.013756E7 -71700.0 -0.06 9383800.0 -522342.5 -0.439227179834147 -0.3008 -0.6777 3069686 PK04_101036 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B17 compound treatment 9483920.0 319000.0 0.27 9920480.0 -289000.0 -0.24 9394640.0 -511502.5 -0.430112044402122 -0.2283 -0.4051 3189136 PK04_101037 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B18 compound treatment 9531120.0 366000.0 0.31 1.013032E7 -79000.0 -0.07 9937680.0 31537.5 0.0265192420375891 0.1593 0.4936 3069687 PK04_101038 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5ccc(CCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B19 compound treatment 9206920.0 41700.0 0.04 9960400.0 -249000.0 -0.21 9515240.0 -390902.5 -0.32870195832259 -0.2883 -0.7395 3189137 PK04_101039 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B20 compound treatment 9472720.0 308000.0 0.26 1.046E7 251000.0 0.21 1.045024E7 544097.5 0.457520516672125 0.537 0.9455 3069688 PK04_101040 OCCc1ccc(cc1)N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B21 compound treatment 8841600.0 -324000.0 -0.28 9093600.0 -1120000.0 -0.93 8869840.0 -1036302.5 -0.871405685982044 -1.1983 -0.9208 3189138 PK04_101041 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B22 compound treatment 9204960.0 39800.0 0.03 9732160.0 -477000.0 -0.4 9488840.0 -417302.5 -0.35090118114597 -0.4114 -0.7761 3189139 PK04_101042 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B23 compound treatment 8785480.0 -380000.0 -0.33 9190920.0 -1020000.0 -0.84 8851160.0 -1054982.5 -0.88711331788889 -1.1886 -0.9375 3069689 PK04_101043 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 B24 compound treatment 8184680.0 -981000.0 -0.84 8691000.0 -1520000.0 -1.26 8659240.0 -1246902.5 -1.04849494077765 -1.8198 -0.9872 3189140 PK04_101044 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C01 compound treatment 8630200.0 -535000.0 -0.46 9229920.0 -979000.0 -0.81 8829080.0 -1077062.5 -0.905679940613899 -1.2578 -0.9669 3189247 PK04_101045 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C02 compound treatment 8771560.0 -394000.0 -0.34 9737880.0 -471000.0 -0.39 9379000.0 -527142.5 -0.44326340216567 -0.6773 -0.9941 3069724 PK04_101046 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C03 compound treatment 8842040.0 -323000.0 -0.28 1.008108E7 -128000.0 -0.11 9494120.0 -412022.5 -0.346461336581294 -0.422 -0.9238 3189248 PK04_101047 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C04 compound treatment 9345920.0 181000.0 0.16 1.01648E7 -44500.0 -0.04 9758280.0 -147862.5 -0.124334567603108 -0.0033 -0.0163 3189249 PK04_101048 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C05 compound treatment 8849520.0 -316000.0 -0.27 1.056352E7 354000.0 0.29 9629800.0 -276342.5 -0.232370785343558 -0.1214 -0.2623 3069725 PK04_101049 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C06 compound treatment 9192760.0 27600.0 0.02 1.00354E7 -174000.0 -0.14 9943160.0 37017.5 0.0311272625327453 -0.0516 -0.3454 3189250 PK04_101050 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C07 compound treatment 8512400.0 -653000.0 -0.56 1.01458E7 -63500.0 -0.05 9669000.0 -237142.5 -0.199408302969448 -0.4699 -0.7852 3069726 PK04_101051 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C08 compound treatment 9243240.0 78000.0 0.07 1.041388E7 205000.0 0.17 9753880.0 -152262.5 -0.128034438073672 0.0628 0.2818 3189251 PK04_101052 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C09 compound treatment 9158560.0 -6650.0 -0.01 1.037272E7 163000.0 0.14 1.017272E7 266577.5 0.224159595537865 0.2044 0.78 3189252 PK04_101053 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C10 compound treatment 9176680.0 11500.0 0.01 1.077656E7 567000.0 0.47 9549640.0 -356502.5 -0.299775698280004 0.1043 0.1869 3069727 PK04_101054 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C11 mock treatment 9109680.0 -55500.0 -0.05 1.060648E7 397000.0 0.33 9825800.0 -80342.5 -0.0675583734730085 0.1236 0.3639 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C12 mock treatment 9756000.0 591000.0 0.51 1.079364E7 584000.0 0.48 1.003408E7 127937.5 0.107580040529023 0.6355 0.8943 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C13 compound treatment 9724960.0 560000.0 0.48 1.092668E7 717000.0 0.6 1.00872E7 181057.5 0.152247567664552 0.7096 0.909 3189253 PK04_101055 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C14 compound treatment 9611280.0 446000.0 0.38 1.059032E7 381000.0 0.32 9911360.0 5217.5 0.00438728958640099 0.4067 0.8178 3069728 PK04_101056 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C15 mock treatment 9025440.0 -140000.0 -0.12 1.037036E7 161000.0 0.13 1.026536E7 359217.5 0.302058686536272 0.1821 0.518 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C16 mock treatment 9329400.0 164000.0 0.14 1.031856E7 109000.0 0.09 1.008916E7 183017.5 0.153895691783257 0.2228 0.9781 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C17 compound treatment 8573760.0 -591000.0 -0.51 1.061256E7 403000.0 0.33 1.023124E7 325097.5 0.273367872796358 0.0571 0.0855 3189254 PK04_101057 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C18 compound treatment 9096320.0 -68900.0 -0.06 1.056352E7 354000.0 0.29 9809240.0 -96902.5 -0.0814833405167651 0.0884 0.2845 3189255 PK04_101058 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C19 compound treatment 8777320.0 -388000.0 -0.33 1.048768E7 278000.0 0.23 9733520.0 -172622.5 -0.145154747796551 -0.1432 -0.3322 3069729 PK04_101059 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C20 compound treatment 8968880.0 -196000.0 -0.17 1.012128E7 -88000.0 -0.07 1.005948E7 153337.5 0.128938383700002 -0.0653 -0.2904 3189256 PK04_101060 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C21 compound treatment 8901280.0 -264000.0 -0.23 9856240.0 -353000.0 -0.29 9224960.0 -681182.5 -0.572792503821484 -0.6309 -0.9248 3189257 PK04_101061 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C22 compound treatment 8508360.0 -657000.0 -0.57 1.011584E7 -93500.0 -0.08 9620680.0 -285462.5 -0.240039607773453 -0.5097 -0.8234 3069730 PK04_101062 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C23 compound treatment 8570920.0 -594000.0 -0.51 9561200.0 -648000.0 -0.54 9625720.0 -280422.5 -0.235801574325354 -0.7419 -0.9528 3189258 PK04_101063 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 C24 compound treatment 7476400.0 -1690000.0 -1.45 8765320.0 -1440000.0 -1.2 8944200.0 -961942.5 -0.808877875029523 -1.9978 -0.9746 3069731 PK04_101064 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D01 compound treatment 8832240.0 -333000.0 -0.29 9407000.0 -802000.0 -0.67 9375160.0 -530982.5 -0.446492380030889 -0.8075 -0.9487 3189259 PK04_101065 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D02 compound treatment 8812280.0 -353000.0 -0.3 9817080.0 -392000.0 -0.33 1.030372E7 397577.5 0.334314830002365 -0.1702 -0.3058 3069687 PK04_101066 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5ccc(CCO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D03 compound treatment 9639240.0 474000.0 0.41 1.028992E7 80600.0 0.07 1.02304E7 324257.5 0.272661533888341 0.4316 0.8715 3189260 PK04_101067 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D04 compound treatment 9623840.0 459000.0 0.39 9805520.0 -404000.0 -0.33 9435600.0 -470542.5 -0.395669613839787 -0.1939 -0.2977 3069688 PK04_101068 OCCc1ccc(cc1)N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D05 compound treatment 8973920.0 -191000.0 -0.16 1.043892E7 230000.0 0.19 1.001076E7 104617.5 0.0879707270350371 0.0657 0.2464 3069732 PK04_101069 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D06 compound treatment 8866280.0 -299000.0 -0.26 1.04216E7 212000.0 0.18 9874240.0 -31902.5 -0.0268261631107154 -0.0623 -0.1992 3189139 PK04_101070 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D07 compound treatment 9730400.0 565000.0 0.49 1.056356E7 354000.0 0.29 1.009604E7 189897.5 0.159680943791774 0.5427 0.9193 3189261 PK04_101071 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D08 compound treatment 1.00232E7 858000.0 0.74 1.081944E7 610000.0 0.51 1.005144E7 145297.5 0.1221777112947 0.7891 0.8733 3069733 PK04_101072 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D09 compound treatment 8926400.0 -239000.0 -0.21 1.060016E7 391000.0 0.32 1.04628E7 556657.5 0.468081965106279 0.3388 0.5596 3189262 PK04_101073 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D10 compound treatment 9380720.0 216000.0 0.19 1.084412E7 635000.0 0.53 1.107884E7 1172697.5 0.986097466171246 0.9805 0.8652 3069733 PK04_101074 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D11 mock treatment 9428280.0 263000.0 0.23 1.057488E7 366000.0 0.3 1.02384E7 332257.5 0.279388571107547 0.4671 0.993 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D12 mock treatment 9729200.0 564000.0 0.49 1.094652E7 737000.0 0.61 1.031504E7 408897.5 0.343833587667542 0.8318 0.975 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D13 compound treatment 9494120.0 329000.0 0.28 1.122184E7 1010000.0 0.84 1.063688E7 730737.5 0.614462294996204 1.0031 0.9301 3189263 PK04_101075 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D14 compound treatment 1.003964E7 874000.0 0.75 1.115652E7 947000.0 0.79 1.121516E7 1309017.5 1.10072618038652 1.5237 0.9845 3069734 PK04_101076 CC(C)(C)N(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D15 mock treatment 9582200.0 417000.0 0.36 1.013052E7 -78800.0 -0.07 1.018748E7 281337.5 0.2365709792073 0.306 0.7039 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D16 mock treatment 9386440.0 221000.0 0.19 1.047848E7 269000.0 0.22 1.139244E7 1486297.5 1.24979732516413 0.9604 0.7481 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D17 compound treatment 9418920.0 254000.0 0.22 1.080256E7 593000.0 0.49 1.09136E7 1007457.5 0.847150512408544 0.8993 0.8959 3189264 PK04_101077 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D18 compound treatment 9233520.0 68300.0 0.06 1.087392E7 665000.0 0.55 1.065084E7 744697.5 0.626200974943719 0.7138 0.8534 3069734 PK04_101078 CC(C)(C)N(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D19 compound treatment 9455360.0 290000.0 0.25 1.068524E7 476000.0 0.39 9883800.0 -22342.5 -0.0187873536337641 0.3613 0.7727 3069735 PK04_101079 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D20 compound treatment 8767440.0 -398000.0 -0.34 1.029004E7 80700.0 0.07 1.02182E7 312057.5 0.262402802129052 -0.0075 -0.0171 3189265 PK04_101080 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCOCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D21 compound treatment 9181920.0 16700.0 0.01 1.04238E7 214000.0 0.18 9866280.0 -39862.5 -0.0335195651438255 0.0917 0.5048 3189266 PK04_101081 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D22 compound treatment 8961440.0 -204000.0 -0.18 1.007844E7 -131000.0 -0.11 9597880.0 -308262.5 -0.259211663848191 -0.3136 -0.9467 3189265 PK04_101082 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCOCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D23 compound treatment 8698400.0 -467000.0 -0.4 1.004044E7 -169000.0 -0.14 9594080.0 -312062.5 -0.262407006527314 -0.4643 -0.9289 3069736 PK04_101083 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 D24 compound treatment 7767160.0 -1400000.0 -1.2 9264240.0 -945000.0 -0.78 9081600.0 -824542.5 -0.693341010789658 -1.5476 -0.9705 3189267 PK04_101084 OCCOCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E01 mock treatment 8699960.0 -465000.0 -0.4 9903560.0 -306000.0 -0.25 9464640.0 -441502.5 -0.371250468734069 -0.592 -0.9832 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E02 mock treatment 9751960.0 587000.0 0.5 1.000608E7 -203000.0 -0.17 9857400.0 -48742.5 -0.0409865764571443 0.1705 0.3194 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E03 compound treatment 8553760.0 -611000.0 -0.53 9988600.0 -221000.0 -0.18 9582160.0 -323982.5 -0.272430291983931 -0.5668 -0.9139 3189373 PK04_101085 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E04 compound treatment 8817160.0 -348000.0 -0.3 1.012992E7 -79400.0 -0.07 1.0134E7 227857.5 0.191600735396907 -0.1003 -0.2775 3189374 PK04_101086 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E05 compound treatment 8795720.0 -369000.0 -0.32 9795880.0 -413000.0 -0.34 1.00394E7 133257.5 0.112053520279795 -0.3169 -0.6589 3069761 PK04_101087 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E06 compound treatment 9231000.0 65800.0 0.06 1.016528E7 -44000.0 -0.04 1.063356E7 727417.5 0.611670574550234 0.3648 0.5927 3189375 PK04_101088 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E07 compound treatment 9693520.0 528000.0 0.45 1.05062E7 297000.0 0.25 1.023976E7 333617.5 0.280532167434812 0.5667 0.9632 3189376 PK04_101089 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E08 compound treatment 9391480.0 226000.0 0.19 1.125176E7 1040000.0 0.86 1.06426E7 736457.5 0.619272126607937 0.9693 0.8964 3069762 PK04_101090 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E09 mock treatment 9410280.0 245000.0 0.21 1.073524E7 526000.0 0.44 1.085928E7 953137.5 0.801473929690134 0.8364 0.893 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E10 mock treatment 9728960.0 564000.0 0.49 1.033716E7 128000.0 0.11 1.10562E7 1150057.5 0.967059950840893 0.8997 0.8276 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E11 compound treatment 8835600.0 -330000.0 -0.28 1.116476E7 955000.0 0.79 1.052908E7 622937.5 0.523815468467402 0.5963 0.6014 3189377 PK04_101091 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E12 compound treatment 9247160.0 82000.0 0.07 1.055708E7 348000.0 0.29 1.007084E7 164697.5 0.138490776551275 0.2872 0.8765 3069763 PK04_101092 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E13 compound treatment 1.039816E7 1230000.0 1.06 1.073448E7 525000.0 0.44 1.066064E7 754497.5 0.634441595537246 1.2305 0.9387 3189378 PK04_101093 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E14 compound treatment 9331040.0 166000.0 0.14 1.10464E7 837000.0 0.69 1.089312E7 986977.5 0.829929297127376 0.9625 0.8818 3189379 PK04_101094 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E15 compound treatment 8753360.0 -412000.0 -0.35 1.044764E7 238000.0 0.2 1.044624E7 540097.5 0.454156998062522 0.1717 0.2819 3069764 PK04_101095 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E16 compound treatment 9502680.0 337000.0 0.29 1.083124E7 622000.0 0.52 1.06342E7 728057.5 0.61220873752777 0.819 0.9617 3189380 PK04_101096 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E17 mock treatment 9739000.0 574000.0 0.49 1.065604E7 447000.0 0.37 1.00382E7 132057.5 0.111044464696914 0.5632 0.8978 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E18 mock treatment 8877720.0 -287000.0 -0.25 1.0129E7 -80300.0 -0.07 1.035448E7 448337.5 0.376997881158228 0.0363 0.0797 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E19 compound treatment 9291160.0 126000.0 0.11 1.030004E7 90700.0 0.08 9890040.0 -16102.5 -0.0135402646027833 0.0982 0.7404 3069765 PK04_101097 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E20 compound treatment 8329800.0 -835000.0 -0.72 1.050232E7 293000.0 0.24 1.032476E7 418617.5 0.352006937888877 -0.0715 -0.0855 3189381 PK04_101098 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E21 compound treatment 8691240.0 -474000.0 -0.41 1.045708E7 248000.0 0.21 9462400.0 -443742.5 -0.373134039155447 -0.3323 -0.5634 3189382 PK04_101099 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E22 compound treatment 8963840.0 -201000.0 -0.17 1.01278E7 -81500.0 -0.07 9286920.0 -619222.5 -0.520691600558733 -0.4397 -0.7953 3069730 PK04_101100 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E23 compound treatment 8635080.0 -530000.0 -0.46 9741800.0 -468000.0 -0.39 9352640.0 -553502.5 -0.465428989802955 -0.756 -0.9969 3069766 PK04_101101 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 E24 compound treatment 9565720.0 401000.0 0.34 9293440.0 -916000.0 -0.76 8676440.0 -1229702.5 -1.03403181075635 -0.8366 -0.6297 3069731 PK04_101102 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F01 mock treatment 8350080.0 -815000.0 -0.7 9709520.0 -500000.0 -0.41 8993720.0 -912422.5 -0.767237514642637 -1.0874 -0.9715 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F02 mock treatment 9838920.0 674000.0 0.58 1.027204E7 62700.0 0.05 9758440.0 -147702.5 -0.124200026858724 0.2931 0.4924 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F03 compound treatment 9409640.0 244000.0 0.21 1.034484E7 136000.0 0.11 9307400.0 -598742.5 -0.503470385277565 -0.1043 -0.1872 3189383 PK04_101103 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F04 compound treatment 9124960.0 -40200.0 -0.03 1.048456E7 275000.0 0.23 1.00616E7 155457.5 0.130721048563092 0.1873 0.7058 3189267 PK04_101104 OCCOCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F05 compound treatment 9354160.0 189000.0 0.16 1.094248E7 733000.0 0.61 9681240.0 -224902.5 -0.189115936024063 0.3359 0.5109 3189384 PK04_101105 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F06 compound treatment 9102320.0 -62900.0 -0.05 1.069504E7 486000.0 0.4 1.040724E7 501097.5 0.421362691618892 0.4447 0.7594 3069767 PK04_101106 CCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F07 compound treatment 9223400.0 58200.0 0.05 1.047888E7 270000.0 0.22 1.067532E7 769177.5 0.64678570883449 0.5314 0.7745 3189385 PK04_101107 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F08 compound treatment 9410520.0 245000.0 0.21 1.089228E7 683000.0 0.57 1.03846E7 478457.5 0.402325176288539 0.6813 0.9381 3069767 PK04_101108 CCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F09 mock treatment 9787480.0 622000.0 0.54 1.047748E7 268000.0 0.22 1.041344E7 507297.5 0.426576145463777 0.6839 0.95 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F10 mock treatment 9339080.0 174000.0 0.15 1.071028E7 501000.0 0.42 1.03646E7 458457.5 0.385507583240524 0.5489 0.9363 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F11 compound treatment 9564520.0 399000.0 0.34 1.06224E7 413000.0 0.34 9902880.0 -3262.5 -0.0027433698659575 0.3947 0.8132 3069768 PK04_101109 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F12 compound treatment 1.015976E7 995000.0 0.86 1.11074E7 898000.0 0.75 1.061204E7 705897.5 0.593574844430569 1.267 0.9894 3189386 PK04_101110 CCCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F13 compound treatment 9255360.0 90200.0 0.08 1.03634E7 154000.0 0.13 1.014132E7 235177.5 0.197755974452481 0.2328 0.9389 3189387 PK04_101111 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F14 compound treatment 1.039344E7 1230000.0 1.06 1.081828E7 609000.0 0.51 1.089968E7 993537.5 0.835445467647125 1.3843 0.962 3189386 PK04_101112 CCCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F15 compound treatment 9154080.0 -11100.0 -0.01 1.063968E7 430000.0 0.36 1.003476E7 128617.5 0.108151838692655 0.263 0.7049 3069769 PK04_101113 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F16 compound treatment 9672760.0 508000.0 0.44 1.101924E7 810000.0 0.67 1.072492E7 818777.5 0.688493339593568 1.0376 0.9821 3189388 PK04_101114 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F17 mock treatment 9381920.0 217000.0 0.19 1.121584E7 1010000.0 0.83 1.068952E7 783377.5 0.65872619989858 0.9701 0.8984 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F18 mock treatment 9391200.0 226000.0 0.19 1.093228E7 723000.0 0.6 1.07932E7 887057.5 0.745908602259492 0.8892 0.9104 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F19 compound treatment 8790520.0 -375000.0 -0.32 9897440.0 -312000.0 -0.26 1.02348E7 328657.5 0.276361404358904 -0.176 -0.3539 3189389 PK04_101115 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F20 compound treatment 9668080.0 503000.0 0.43 9885960.0 -323000.0 -0.27 1.005152E7 145377.5 0.122244981666892 0.1656 0.3162 3189388 PK04_101116 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F21 compound treatment 8680400.0 -485000.0 -0.42 1.070816E7 499000.0 0.41 1.031092E7 404777.5 0.340369163499651 0.1945 0.2865 3069770 PK04_101117 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F22 compound treatment 8608880.0 -556000.0 -0.48 1.012732E7 -82000.0 -0.07 1.000188E7 95737.5 0.0805037157217183 -0.2692 -0.5491 3189390 PK04_101118 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F23 compound treatment 8994440.0 -171000.0 -0.15 9929000.0 -280000.0 -0.23 9656360.0 -249782.5 -0.210037021775794 -0.3404 -0.9834 3189391 PK04_101119 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 F24 compound treatment 8583680.0 -582000.0 -0.5 9742560.0 -467000.0 -0.39 9006840.0 -899302.5 -0.756205173603139 -0.9491 -0.9625 3189390 PK04_101120 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G01 compound treatment 8538240.0 -627000.0 -0.54 9051840.0 -1160000.0 -0.96 8616120.0 -1290022.5 -1.08475367138917 -1.4922 -0.9653 3189392 PK04_101121 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G02 compound treatment 8913280.0 -252000.0 -0.22 9455520.0 -754000.0 -0.63 9592640.0 -313502.5 -0.263617873226771 -0.6384 -0.8961 3189374 PK04_101122 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G03 mock treatment 8957640.0 -208000.0 -0.18 9776840.0 -432000.0 -0.36 9985240.0 79097.5 0.0665114783057695 -0.2719 -0.6692 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G04 mock treatment 9318040.0 153000.0 0.13 1.004544E7 -164000.0 -0.14 9936320.0 30177.5 0.0253756457103241 0.0121 0.0634 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G05 compound treatment 8872880.0 -292000.0 -0.25 1.016376E7 -45500.0 -0.04 9474400.0 -431742.5 -0.363043483326637 -0.3767 -0.8497 3069794 PK04_101123 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G06 compound treatment 9688120.0 523000.0 0.45 1.094892E7 740000.0 0.61 9756720.0 -149422.5 -0.125646339860853 0.5415 0.7022 3189375 PK04_101124 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G07 compound treatment 9699200.0 534000.0 0.46 1.045228E7 243000.0 0.2 1.022012E7 313977.5 0.264017291061661 0.5341 0.942 3189393 PK04_101125 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G08 compound treatment 9561280.0 396000.0 0.34 1.094128E7 732000.0 0.61 9807280.0 -98862.5 -0.0831314646354707 0.4994 0.7121 3069762 PK04_101126 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G09 compound treatment 9295680.0 130000.0 0.11 1.0797E7 588000.0 0.49 9733240.0 -172902.5 -0.145390194099223 0.2624 0.5036 3069795 PK04_101127 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G10 compound treatment 9454640.0 289000.0 0.25 1.096592E7 757000.0 0.63 1.015848E7 252337.5 0.212185469287678 0.6287 0.8882 3069763 PK04_101128 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G11 compound treatment 9971640.0 806000.0 0.69 1.144668E7 1240000.0 1.03 1.04162E7 510057.5 0.428896973304403 1.241 0.9464 3189504 PK04_101129 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G12 compound treatment 9593120.0 428000.0 0.37 1.183232E7 1620000.0 1.35 1.04372E7 531057.5 0.446555446004819 1.2478 0.8514 3189379 PK04_101130 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G13 compound treatment 9383240.0 218000.0 0.19 1.051796E7 309000.0 0.26 1.079304E7 886897.5 0.745774061515108 0.6867 0.8473 3069796 PK04_101131 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G14 compound treatment 9683160.0 518000.0 0.45 1.061612E7 407000.0 0.34 1.000872E7 102577.5 0.0862553325441395 0.502 0.8874 3189380 PK04_101132 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G15 compound treatment 9305560.0 140000.0 0.12 1.05304E7 321000.0 0.27 1.040264E7 496497.5 0.417494645217849 0.4646 0.9114 3189505 PK04_101133 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G16 compound treatment 8974720.0 -190000.0 -0.16 1.085572E7 646000.0 0.54 1.037352E7 467377.5 0.393008229739939 0.4419 0.6453 3189381 PK04_101134 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G17 compound treatment 9064080.0 -101000.0 -0.09 1.115388E7 945000.0 0.78 9855000.0 -51142.5 -0.0430046876229061 0.3773 0.4779 3189506 PK04_101135 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G18 compound treatment 9282000.0 117000.0 0.1 1.049592E7 287000.0 0.24 1.057496E7 668817.5 0.562395026919549 0.52 0.8403 3069797 PK04_101136 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G19 mock treatment 8975640.0 -190000.0 -0.16 1.053112E7 322000.0 0.27 9887040.0 -19102.5 -0.0160629035599856 0.0507 0.1617 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G20 mock treatment 8935640.0 -230000.0 -0.2 1.039764E7 188000.0 0.16 1.007848E7 172337.5 0.144915097095617 0.0598 0.2058 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G21 compound treatment 9149680.0 -15500.0 -0.01 1.089804E7 689000.0 0.57 1.013344E7 227297.5 0.191129842791563 0.4325 0.7177 3189507 PK04_101137 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G22 compound treatment 8725240.0 -440000.0 -0.38 9845680.0 -364000.0 -0.3 9284280.0 -621862.5 -0.522911522841071 -0.6947 -0.9748 3189508 PK04_101138 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G23 compound treatment 8615200.0 -550000.0 -0.47 1.01832E7 -26100.0 -0.02 9519760.0 -386382.5 -0.324901182293739 -0.4734 -0.8239 3069798 PK04_101139 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 G24 compound treatment 8339880.0 -825000.0 -0.71 9467280.0 -742000.0 -0.62 8941400.0 -964742.5 -0.811232338056245 -1.2339 -0.9938 3189509 PK04_101140 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H01 compound treatment 8643480.0 -522000.0 -0.45 9533080.0 -676000.0 -0.56 9423480.0 -482662.5 -0.405861075226884 -0.8174 -0.9905 3069799 PK04_101141 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H02 compound treatment 9310000.0 145000.0 0.12 9772160.0 -437000.0 -0.36 9505880.0 -400262.5 -0.336572591869061 -0.3317 -0.6502 3189510 PK04_101142 CC(C)(CO)N1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H03 mock treatment 9152280.0 -12900.0 -0.01 1.026024E7 50900.0 0.04 9988240.0 82097.5 0.0690341172629718 0.0578 0.7078 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H04 mock treatment 9412960.0 248000.0 0.21 1.070596E7 497000.0 0.41 1.044324E7 537097.5 0.45163435910532 0.6217 0.9603 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H05 compound treatment 9205240.0 40000.0 0.03 1.074988E7 541000.0 0.45 9873400.0 -32742.5 -0.0275325020187321 0.2629 0.5834 3189511 PK04_101143 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H06 compound treatment 9979000.0 814000.0 0.7 1.083788E7 629000.0 0.52 1.0199E7 292857.5 0.246257912802957 0.8476 0.9343 3069800 PK04_101144 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H07 compound treatment 9739800.0 575000.0 0.49 1.032708E7 118000.0 0.1 1.049496E7 588817.5 0.495124654727488 0.6278 0.8885 3189512 PK04_101145 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H08 compound treatment 9625720.0 461000.0 0.4 1.058812E7 379000.0 0.31 1.011588E7 209737.5 0.176363996095405 0.5121 0.956 3069800 PK04_101146 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H09 compound treatment 9226280.0 61100.0 0.05 1.079124E7 582000.0 0.48 1.006796E7 161817.5 0.136069043152361 0.3876 0.7686 3189513 PK04_101147 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H10 compound treatment 9746600.0 581000.0 0.5 1.108292E7 874000.0 0.72 1.077816E7 872017.5 0.733261772287384 1.1307 0.9866 3189510 PK04_101148 CC(C)(CO)N1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H11 compound treatment 9755080.0 590000.0 0.51 1.146684E7 1260000.0 1.04 1.058448E7 678337.5 0.570400201210404 1.2247 0.9473 3069801 PK04_101149 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H12 compound treatment 9799320.0 634000.0 0.55 1.113208E7 923000.0 0.77 1.08934E7 987257.5 0.830164743430048 1.2363 0.9858 3189514 PK04_101150 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H13 compound treatment 9729760.0 565000.0 0.49 1.108084E7 872000.0 0.72 1.058652E7 680377.5 0.572115595701302 1.0283 0.9866 3189515 PK04_101151 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H14 compound treatment 1.03778E7 1210000.0 1.04 1.03244E7 115000.0 0.1 1.08692E7 963057.5 0.80981545584195 1.1252 0.8496 3189514 PK04_101152 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H15 compound treatment 9651520.0 486000.0 0.42 1.087292E7 664000.0 0.55 1.086664E7 960497.5 0.807662803931804 1.0258 0.9647 3069802 PK04_101153 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H16 compound treatment 9296080.0 131000.0 0.11 1.115428E7 945000.0 0.78 1.085936E7 953217.5 0.801541200062326 0.9804 0.8701 3189516 PK04_101154 CC(C)(C)N(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H17 compound treatment 9973080.0 808000.0 0.7 1.082236E7 613000.0 0.51 1.04368E7 530657.5 0.446219094143859 0.9527 0.982 3189517 PK04_101155 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H18 compound treatment 9756040.0 591000.0 0.51 1.101548E7 806000.0 0.67 1.12184E7 1312257.5 1.1034506304603 1.3168 0.9495 3189516 PK04_101156 CC(C)(C)N(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H19 mock treatment 8887000.0 -278000.0 -0.24 1.068196E7 473000.0 0.39 1.080576E7 899617.5 0.756470050693645 0.5249 0.5931 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H20 mock treatment 8899440.0 -266000.0 -0.23 1.041788E7 209000.0 0.17 1.052448E7 618337.5 0.519947422066358 0.268 0.4514 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H21 compound treatment 8480720.0 -684000.0 -0.59 1.031664E7 107000.0 0.09 1.023852E7 332377.5 0.279489476665835 -0.1273 -0.1935 3069803 PK04_101157 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H22 compound treatment 8385480.0 -780000.0 -0.67 1.015224E7 -57100.0 -0.05 9829040.0 -77102.5 -0.06483392339923 -0.4522 -0.6691 3189518 PK04_101158 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCCCCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H23 compound treatment 8810960.0 -354000.0 -0.3 1.06746E7 465000.0 0.39 9952480.0 46337.5 0.0389642608931205 0.0693 0.1405 3069804 PK04_101159 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 H24 compound treatment 8085640.0 -1080000.0 -0.93 9500600.0 -709000.0 -0.59 9448960.0 -457182.5 -0.384435461683713 -1.0978 -0.9425 3189518 PK04_101160 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCCCCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I01 compound treatment 8231560.0 -934000.0 -0.8 8669760.0 -1540000.0 -1.28 8378160.0 -1527982.5 -1.28484939347445 -1.9431 -0.9805 3189519 PK04_101161 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I02 compound treatment 8215280.0 -950000.0 -0.82 1.008636E7 -123000.0 -0.1 9341880.0 -564262.5 -0.474476854862787 -0.8048 -0.8465 3189520 PK04_101162 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I03 compound treatment 9100200.0 -65000.0 -0.06 1.000664E7 -203000.0 -0.17 9610880.0 -295262.5 -0.248280228366981 -0.2727 -0.8941 3069839 PK04_101163 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I04 compound treatment 8974640.0 -191000.0 -0.16 9877920.0 -331000.0 -0.27 9609480.0 -296662.5 -0.249457459880342 -0.3974 -0.9793 3189521 PK04_101164 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I05 mock treatment 8891200.0 -274000.0 -0.24 9696560.0 -513000.0 -0.43 9332880.0 -573262.5 -0.482044771734394 -0.66 -0.9639 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I06 mock treatment 9165840.0 631.0 0.0 1.0441E7 232000.0 0.19 9310560.0 -595582.5 -0.500813205575979 -0.1779 -0.3316 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I07 compound treatment 9613240.0 448000.0 0.39 1.017108E7 -38200.0 -0.03 9805080.0 -101062.5 -0.0849813998707523 0.1552 0.3919 3069840 PK04_101165 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I08 compound treatment 9651240.0 486000.0 0.42 1.052108E7 312000.0 0.26 1.044032E7 534177.5 0.44917899052031 0.6502 0.9761 3189522 PK04_101166 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I09 compound treatment 9579280.0 414000.0 0.36 1.014324E7 -66100.0 -0.05 1.046324E7 557097.5 0.468451952153335 0.4446 0.752 3189523 PK04_101167 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I10 compound treatment 9810160.0 645000.0 0.56 1.062884E7 420000.0 0.35 9884200.0 -21942.5 -0.0184510017728038 0.5108 0.7793 3069841 PK04_101168 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I11 compound treatment 9550600.0 385000.0 0.33 1.084084E7 632000.0 0.52 1.011616E7 210017.5 0.176599442398078 0.5959 0.9243 3189524 PK04_101169 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I12 compound treatment 9712600.0 547000.0 0.47 1.098436E7 775000.0 0.64 1.094356E7 1037417.5 0.872343266794471 1.1469 0.9705 3189640 PK04_101170 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I13 compound treatment 9719720.0 555000.0 0.48 1.074668E7 537000.0 0.45 1.0022E7 115857.5 0.0974222143280216 0.5892 0.8923 3069842 PK04_101171 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I14 compound treatment 9662360.0 497000.0 0.43 1.040128E7 192000.0 0.16 1.043732E7 531177.5 0.446656351563107 0.5969 0.9345 3189641 PK04_101172 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I15 compound treatment 9543920.0 379000.0 0.33 1.081548E7 606000.0 0.5 1.040208E7 495937.5 0.417023752612504 0.7193 0.9852 3069843 PK04_101173 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I16 compound treatment 9390600.0 225000.0 0.19 1.062548E7 416000.0 0.35 9979120.0 72977.5 0.0613652948330768 0.3467 0.8653 3189642 PK04_101174 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I17 compound treatment 9568920.0 404000.0 0.35 1.057152E7 362000.0 0.3 1.038208E7 475937.5 0.400206159564489 0.6051 0.9933 3069844 PK04_101175 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I18 compound treatment 9469560.0 304000.0 0.26 1.02478E7 38500.0 0.03 9934960.0 28817.5 0.0242320493830591 0.1837 0.6931 3189643 PK04_101176 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I19 compound treatment 8962600.0 -203000.0 -0.17 1.021184E7 2530.0 0.0 1.073928E7 833137.5 0.700568371402043 0.305 0.4225 3069845 PK04_101177 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I20 compound treatment 9170840.0 5630.0 0.0 1.060384E7 395000.0 0.33 1.0021E7 114857.5 0.0965813346756209 0.2475 0.7253 3189644 PK04_101178 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I21 mock treatment 8931280.0 -234000.0 -0.2 1.014192E7 -67400.0 -0.06 9743480.0 -162662.5 -0.136779586458639 -0.2275 -0.9109 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I22 mock treatment 8704320.0 -461000.0 -0.4 1.02452E7 35900.0 0.03 9924960.0 18817.5 0.0158232528590514 -0.2027 -0.5091 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I23 compound treatment 8754400.0 -411000.0 -0.35 1.010624E7 -103000.0 -0.09 9319600.0 -586542.5 -0.493211653518276 -0.5382 -0.8783 3189645 PK04_101179 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 I24 compound treatment 1.047972E7 1310000.0 1.13 9141080.0 -1070000.0 -0.89 9620560.0 -285582.5 -0.240140513331742 0.0029 0.002 3069846 PK04_101180 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J01 compound treatment 8003440.0 -1160000.0 -1.0 9109240.0 -1100000.0 -0.91 8044440.0 -1861702.5 -1.56546775107364 -2.008 -0.9702 3189646 PK04_101181 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J02 compound treatment 8630520.0 -535000.0 -0.46 9608080.0 -601000.0 -0.5 9425000.0 -481142.5 -0.404582938155235 -0.7872 -0.9964 3189647 PK04_101182 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J03 compound treatment 8356600.0 -809000.0 -0.7 9869000.0 -340000.0 -0.28 8925240.0 -980902.5 -0.824820953239042 -1.041 -0.9332 3069847 PK04_101183 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J04 compound treatment 9027280.0 -138000.0 -0.12 9822920.0 -386000.0 -0.32 1.001764E7 111497.5 0.0937559790435543 -0.1995 -0.5628 3189647 PK04_101184 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J05 mock treatment 9031280.0 -134000.0 -0.12 1.001744E7 -192000.0 -0.16 9830360.0 -75782.5 -0.063723962258061 -0.1952 -0.945 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J06 mock treatment 9887720.0 723000.0 0.62 9923120.0 -286000.0 -0.24 1.00336E7 127457.5 0.107176418295871 0.2838 0.421 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J07 compound treatment 9351120.0 186000.0 0.16 9986480.0 -223000.0 -0.18 1.005372E7 147577.5 0.124094916902174 0.0573 0.209 3189648 PK04_101185 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J08 compound treatment 9452720.0 288000.0 0.25 1.085E7 641000.0 0.53 1.090672E7 1000577.5 0.841365260400027 0.9355 0.9122 3189649 PK04_101186 CCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J09 compound treatment 9474040.0 309000.0 0.27 1.005392E7 -155000.0 -0.13 1.037228E7 466137.5 0.391965538970962 0.3053 0.6221 3069848 PK04_101187 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J10 compound treatment 9002560.0 -163000.0 -0.14 1.105456E7 845000.0 0.7 1.058072E7 674577.5 0.567238493717377 0.6515 0.7138 3189649 PK04_101188 CCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J11 compound treatment 9680400.0 515000.0 0.44 1.02904E7 81100.0 0.07 9946280.0 40137.5 0.0337508070482357 0.3143 0.6989 3189650 PK04_101189 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J12 compound treatment 1.012556E7 960000.0 0.83 1.067544E7 466000.0 0.39 1.026348E7 357337.5 0.300477832789758 0.8739 0.9097 3189651 PK04_101190 CCCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J13 compound treatment 9576520.0 411000.0 0.35 1.102132E7 812000.0 0.67 1.096452E7 1058377.5 0.889968104308791 1.1071 0.9455 3069849 PK04_101191 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J14 compound treatment 9812480.0 647000.0 0.56 1.109196E7 883000.0 0.73 1.084428E7 938137.5 0.788860734904123 1.1998 0.99 3189651 PK04_101192 CCCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J15 compound treatment 9607000.0 442000.0 0.38 1.045096E7 242000.0 0.2 1.068208E7 775937.5 0.652470055284719 0.712 0.9112 3189652 PK04_101193 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J16 compound treatment 9467760.0 303000.0 0.26 1.073836E7 529000.0 0.44 9950120.0 43977.5 0.0369797849134546 0.4251 0.8308 3069850 PK04_101194 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J17 compound treatment 9487800.0 323000.0 0.28 1.033316E7 124000.0 0.1 9509400.0 -396742.5 -0.333612695492611 0.027 0.0605 3189653 PK04_101195 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J18 compound treatment 9487360.0 322000.0 0.28 1.081012E7 601000.0 0.5 9785200.0 -120942.5 -0.10169808736048 0.3891 0.6717 3069850 PK04_101196 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J19 compound treatment 8765520.0 -400000.0 -0.34 9790000.0 -419000.0 -0.35 1.207724E7 2171097.5 1.82563171112817 0.6546 0.3463 3189654 PK04_101197 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J20 compound treatment 9663040.0 498000.0 0.43 1.012436E7 -84900.0 -0.07 1.010412E7 197977.5 0.166475251383172 0.3028 0.6511 3069851 PK04_101198 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2c(Cl)cccc2CO)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J21 mock treatment 9317920.0 153000.0 0.13 9845960.0 -363000.0 -0.3 9937680.0 31537.5 0.0265192420375891 -0.0828 -0.2511 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J22 mock treatment 8391040.0 -774000.0 -0.67 1.013508E7 -74200.0 -0.06 9383680.0 -522462.5 -0.439328085392435 -0.6739 -0.8419 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J23 compound treatment 9000760.0 -164000.0 -0.14 9182400.0 -1030000.0 -0.85 8943960.0 -962182.5 -0.809079686146099 -1.0407 -0.8794 3189655 PK04_101199 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 J24 compound treatment 8602480.0 -563000.0 -0.48 8730800.0 -1480000.0 -1.23 8623560.0 -1282582.5 -1.0784975267753 -1.6104 -0.9453 3069851 PK04_101200 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2c(Cl)cccc2CO)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K01 compound treatment 8425080.0 -740000.0 -0.64 9058280.0 -1150000.0 -0.95 8724240.0 -1181902.5 -0.993837763371595 -1.4928 -0.9832 3189656 PK04_101201 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K02 compound treatment 8790120.0 -375000.0 -0.32 9682120.0 -527000.0 -0.44 9585080.0 -321062.5 -0.269974923398921 -0.5947 -0.9799 3189657 PK04_101202 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K03 compound treatment 8522480.0 -643000.0 -0.55 1.002552E7 -184000.0 -0.15 9526440.0 -379702.5 -0.319284106215702 -0.5917 -0.9012 3069890 PK04_101203 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K04 compound treatment 9120400.0 -44800.0 -0.04 1.064828E7 439000.0 0.36 9198400.0 -707742.5 -0.595126267389249 -0.1556 -0.2227 3189658 PK04_101204 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCC(C)OC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K05 compound treatment 9080800.0 -84400.0 -0.07 1.027116E7 61900.0 0.05 9855160.0 -50982.5 -0.042870146878522 -0.0371 -0.3755 3069891 PK04_101205 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K06 compound treatment 8891560.0 -274000.0 -0.24 9725360.0 -484000.0 -0.4 1.044164E7 535497.5 0.450288951661479 -0.1078 -0.1664 3189659 PK04_101206 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K07 mock treatment 9645480.0 480000.0 0.41 1.021588E7 6570.0 0.01 1.008048E7 174337.5 0.146596856400418 0.3264 0.7442 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K08 mock treatment 9315240.0 150000.0 0.13 1.035196E7 143000.0 0.12 9760160.0 -145982.5 -0.122753713856595 0.072 0.3366 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K09 compound treatment 9214480.0 49300.0 0.04 1.022892E7 19600.0 0.02 9680520.0 -225622.5 -0.189721369373792 -0.0757 -0.3878 3187684 PK04_101207 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K10 compound treatment 9961000.0 796000.0 0.68 1.077376E7 564000.0 0.47 9921880.0 15737.5 0.013233343529657 0.6734 0.8116 3069892 PK04_101208 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K11 compound treatment 9552080.0 387000.0 0.33 1.061784E7 409000.0 0.34 1.012752E7 221377.5 0.18615183524935 0.4954 0.9708 3187685 PK04_101209 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K12 compound treatment 1.032608E7 1160000.0 1.0 1.073756E7 528000.0 0.44 1.062268E7 716537.5 0.602521803932113 1.1777 0.945 3187686 PK04_101210 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K13 compound treatment 9748600.0 583000.0 0.5 1.117652E7 967000.0 0.8 1.042172E7 515577.5 0.433538628985655 1.0034 0.9638 3069893 PK04_101211 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K14 compound treatment 9990720.0 826000.0 0.71 1.077624E7 567000.0 0.47 1.008916E7 183017.5 0.153895691783257 0.7706 0.89 3187687 PK04_101212 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K15 mock treatment 9568440.0 403000.0 0.35 1.08942E7 685000.0 0.57 1.02954E7 389257.5 0.327318711294391 0.7174 0.967 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K16 mock treatment 8967800.0 -197000.0 -0.17 1.048036E7 271000.0 0.22 9747480.0 -158662.5 -0.133416067849036 -0.0453 -0.1453 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K17 compound treatment 9239000.0 73800.0 0.06 1.051028E7 301000.0 0.25 1.03158E7 409657.5 0.344472656203366 0.3797 0.8827 3069894 PK04_101213 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K18 compound treatment 9483240.0 318000.0 0.27 1.0567E7 358000.0 0.3 1.025664E7 350497.5 0.294726215967337 0.4995 0.9993 3187688 PK04_101214 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K19 compound treatment 9071520.0 -93700.0 -0.08 1.018016E7 -29100.0 -0.02 1.044144E7 535297.5 0.450120775730999 0.1994 0.4354 3069895 PK04_101215 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K20 compound treatment 9281760.0 117000.0 0.1 9839600.0 -370000.0 -0.31 9482440.0 -423702.5 -0.356282810921335 -0.3249 -0.6758 3187689 PK04_101216 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K21 compound treatment 8849200.0 -316000.0 -0.27 9561000.0 -648000.0 -0.54 9743200.0 -162942.5 -0.137015032761312 -0.5466 -0.8845 3187690 PK04_101217 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K22 compound treatment 8718000.0 -447000.0 -0.38 9843400.0 -366000.0 -0.3 8772840.0 -1133302.5 -0.952971012264918 -0.9477 -0.8843 3069896 PK04_101218 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K23 mock treatment 8772880.0 -392000.0 -0.34 9768000.0 -441000.0 -0.37 9214320.0 -691822.5 -0.581739463323028 -0.7422 -0.9691 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 K24 mock treatment 8188160.0 -977000.0 -0.84 8705880.0 -1500000.0 -1.25 8802240.0 -1103902.5 -0.928249150484336 -1.7415 -0.9853 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L01 compound treatment 8742040.0 -423000.0 -0.36 9454080.0 -755000.0 -0.63 9118080.0 -788062.5 -0.662665721070078 -0.9546 -0.9721 3187691 PK04_101219 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L02 compound treatment 8785720.0 -379000.0 -0.33 1.019124E7 -18100.0 -0.01 8278120.0 -1628022.5 -1.36897099390062 -0.9876 -0.7017 3187692 PK04_101220 OCc1cccc(Cl)c1N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L03 compound treatment 9269080.0 104000.0 0.09 1.024192E7 32600.0 0.03 9697280.0 -208862.5 -0.175628226399555 -0.0342 -0.1718 3069897 PK04_101221 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L04 compound treatment 9037960.0 -127000.0 -0.11 1.05584E7 349000.0 0.29 9619200.0 -286942.5 -0.241284109659007 -0.0353 -0.09 3187693 PK04_101222 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L05 compound treatment 9118360.0 -46800.0 -0.04 1.045776E7 248000.0 0.21 1.049376E7 587617.5 0.494115599144607 0.381 0.7096 3187694 PK04_101223 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L06 compound treatment 9450000.0 285000.0 0.25 1.055292E7 344000.0 0.29 9932800.0 26657.5 0.0224157493338734 0.319 0.8471 3187693 PK04_101224 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L07 mock treatment 9034440.0 -131000.0 -0.11 1.05092E7 300000.0 0.25 1.041728E7 511137.5 0.429805123328996 0.3268 0.6418 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L08 mock treatment 9696760.0 532000.0 0.46 1.042108E7 212000.0 0.18 9851760.0 -54382.5 -0.0457291376966846 0.3391 0.6891 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L09 compound treatment 9010480.0 -155000.0 -0.13 1.087352E7 664000.0 0.55 9985760.0 79617.5 0.0669487357250179 0.2799 0.4903 3069898 PK04_101225 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L10 compound treatment 9642520.0 477000.0 0.41 1.084896E7 640000.0 0.53 9953720.0 47577.5 0.0400069516620974 0.5666 0.8429 3187692 PK04_101226 OCc1cccc(Cl)c1N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L11 compound treatment 9902680.0 737000.0 0.63 1.040768E7 198000.0 0.16 1.004656E7 140417.5 0.118074218590984 0.5296 0.795 3187695 PK04_101227 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L12 compound treatment 9795960.0 631000.0 0.54 1.05516E7 342000.0 0.28 1.050096E7 594817.5 0.500169932641892 0.7661 0.9687 3187696 PK04_101228 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L13 compound treatment 9797320.0 632000.0 0.54 1.111588E7 907000.0 0.75 1.030392E7 397777.5 0.334483005932845 0.9414 0.9542 3069899 PK04_101229 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L14 compound treatment 9496320.0 331000.0 0.28 1.059776E7 388000.0 0.32 1.015748E7 251337.5 0.211344589635277 0.4726 0.986 3187696 PK04_101230 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L15 mock treatment 9770880.0 606000.0 0.52 1.022436E7 15100.0 0.01 9846560.0 -59582.5 -0.0501017118891686 0.2792 0.5331 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L16 mock treatment 8960360.0 -205000.0 -0.18 1.016212E7 -47200.0 -0.04 1.049088E7 584737.5 0.491693865745692 0.1595 0.3045 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L17 compound treatment 8941720.0 -223000.0 -0.19 1.030168E7 92400.0 0.08 9899280.0 -6862.5 -0.00577053661460025 -0.0701 -0.3386 3187697 PK04_101231 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L18 compound treatment 8996280.0 -169000.0 -0.15 1.058488E7 376000.0 0.31 1.015436E7 248217.5 0.208721045119787 0.2164 0.5381 3187698 PK04_101232 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L19 compound treatment 9240960.0 75800.0 0.07 1.04352E7 226000.0 0.19 1.02634E7 357257.5 0.300410562417566 0.3193 0.8868 3069900 PK04_101233 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L20 compound treatment 8962760.0 -202000.0 -0.17 1.00542E7 -155000.0 -0.13 9762280.0 -143862.5 -0.120971048993505 -0.2447 -0.9864 3187698 PK04_101234 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L21 compound treatment 9144600.0 -20600.0 -0.02 9383760.0 -826000.0 -0.68 9045360.0 -860782.5 -0.723814489392662 -0.8235 -0.8263 3187699 PK04_101235 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L22 compound treatment 9003400.0 -162000.0 -0.14 9723560.0 -486000.0 -0.4 8602960.0 -1303182.5 -1.09581964761476 -0.9457 -0.8043 3187700 PK04_101236 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2ccc(CCO)cc2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L23 mock treatment 9075480.0 -89700.0 -0.08 9770000.0 -439000.0 -0.36 9319320.0 -586822.5 -0.493447099820948 -0.5399 -0.8732 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 L24 mock treatment 8308480.0 -857000.0 -0.74 9000600.0 -1210000.0 -1.0 8669080.0 -1237062.5 -1.04022068499802 -1.6052 -0.9896 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M01 compound treatment 8661800.0 -503000.0 -0.43 8488320.0 -1720000.0 -1.43 8647480.0 -1258662.5 -1.05838368548988 -1.6855 -0.9214 3187701 PK04_101237 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M02 compound treatment 8203720.0 -961000.0 -0.83 9292080.0 -917000.0 -0.76 8634120.0 -1272022.5 -1.06961783764595 -1.5346 -0.989 3069926 PK04_101238 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M03 compound treatment 8434800.0 -730000.0 -0.63 9373520.0 -836000.0 -0.69 8684880.0 -1221262.5 -1.02693478649009 -1.3561 -0.976 3187702 PK04_101239 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M04 compound treatment 8458080.0 -707000.0 -0.61 9237960.0 -971000.0 -0.81 9325360.0 -580782.5 -0.488368186720447 -1.0986 -0.9794 3069927 PK04_101240 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M05 compound treatment 8729440.0 -436000.0 -0.38 9803040.0 -406000.0 -0.34 9353440.0 -552702.5 -0.464756286081034 -0.6794 -0.9908 3187703 PK04_101241 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M06 compound treatment 9040400.0 -125000.0 -0.11 9734200.0 -475000.0 -0.39 8995920.0 -910222.5 -0.765387579407355 -0.7315 -0.8431 3187824 PK04_101242 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCC(C)OC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M07 compound treatment 9049760.0 -115000.0 -0.1 9921560.0 -288000.0 -0.24 9007480.0 -898662.5 -0.755667010625603 -0.6315 -0.7906 3069928 PK04_101243 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M08 compound treatment 8190840.0 -974000.0 -0.84 9617560.0 -592000.0 -0.49 8461560.0 -1444582.5 -1.21472003046423 -1.4689 -0.9443 3187825 PK04_101244 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M09 mock treatment 8910360.0 -255000.0 -0.22 9761320.0 -448000.0 -0.37 9653520.0 -252622.5 -0.212425119988612 -0.4638 -0.9644 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M10 mock treatment 8765920.0 -399000.0 -0.34 1.027892E7 69600.0 0.06 1.01466E7 240457.5 0.202195819017157 -0.0483 -0.1199 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M11 compound treatment 9566200.0 401000.0 0.35 1.0791E7 582000.0 0.48 1.00224E7 116257.5 0.097758566188982 0.5343 0.8886 3187826 PK04_101245 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M12 compound treatment 8634800.0 -530000.0 -0.46 1.013828E7 -71000.0 -0.06 9692880.0 -213262.5 -0.179328096870118 -0.4011 -0.812 3069929 PK04_101246 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M13 mock treatment 8999400.0 -166000.0 -0.14 1.022872E7 19400.0 0.02 1.028284E7 376697.5 0.316757262860237 0.1098 0.3157 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M14 mock treatment 9488440.0 323000.0 0.28 1.044612E7 237000.0 0.2 9598160.0 -307982.5 -0.258976217545519 0.1245 0.291 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M15 compound treatment 8954960.0 -210000.0 -0.18 1.050856E7 299000.0 0.25 9766560.0 -139582.5 -0.11737208408123 -0.0289 -0.0879 3187827 PK04_101247 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M16 compound treatment 8797200.0 -368000.0 -0.32 1.011632E7 -93000.0 -0.08 9812640.0 -93502.5 -0.0786243496986025 -0.2728 -0.8135 3187828 PK04_101248 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M17 compound treatment 9551960.0 387000.0 0.33 1.0436E7 227000.0 0.19 9864280.0 -41862.5 -0.035201324448627 0.2804 0.7304 3069930 PK04_101249 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M18 compound treatment 8940680.0 -225000.0 -0.19 9690360.0 -519000.0 -0.43 9458040.0 -448102.5 -0.376800274439914 -0.5777 -0.9566 3187829 PK04_101250 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M19 compound treatment 8869840.0 -295000.0 -0.25 1.029704E7 87700.0 0.07 9468560.0 -437582.5 -0.367954220496658 -0.3172 -0.7 3069931 PK04_101251 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M20 compound treatment 8679400.0 -486000.0 -0.42 1.055236E7 343000.0 0.28 9926560.0 20417.5 0.0171686603028926 -0.0672 -0.1327 3187830 PK04_101252 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M21 compound treatment 8693800.0 -471000.0 -0.41 9986720.0 -223000.0 -0.18 8984480.0 -921662.5 -0.77500724263082 -0.7883 -0.8817 3187831 PK04_101253 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M22 compound treatment 8299080.0 -866000.0 -0.75 9337920.0 -871000.0 -0.72 8723760.0 -1182382.5 -0.994241385604748 -1.4218 -0.989 3069932 PK04_101254 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M23 compound treatment 7991920.0 -1170000.0 -1.01 9459560.0 -750000.0 -0.62 9345800.0 -560342.5 -0.471180606625376 -1.2141 -0.9514 3187832 PK04_101255 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 M24 compound treatment 7587440.0 -1580000.0 -1.36 8453200.0 -1760000.0 -1.46 8198400.0 -1707742.5 -1.43600591979001 -2.4542 -0.9995 3187833 PK04_101256 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N01 compound treatment 8059200.0 -1110000.0 -0.95 8694720.0 -1510000.0 -1.26 8640280.0 -1265862.5 -1.06443801898716 -1.8895 -0.9934 3069933 PK04_101257 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N02 compound treatment 8401440.0 -764000.0 -0.66 1.000748E7 -202000.0 -0.17 8982280.0 -923862.5 -0.776857177866102 -0.9247 -0.8966 3187700 PK04_101258 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2ccc(CCO)cc2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N03 compound treatment 9195800.0 30600.0 0.03 9946360.0 -263000.0 -0.22 9521200.0 -384942.5 -0.323690315594282 -0.2976 -0.7608 3187834 PK04_101259 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N04 compound treatment 9378120.0 213000.0 0.18 1.015884E7 -50500.0 -0.04 8927920.0 -978222.5 -0.822567395770608 -0.3933 -0.4661 3069934 PK04_101260 OCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N05 compound treatment 8624720.0 -540000.0 -0.47 9962600.0 -247000.0 -0.2 9476520.0 -429622.5 -0.361260818463548 -0.5953 -0.9547 3187835 PK04_101261 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N06 compound treatment 9519640.0 354000.0 0.31 1.011632E7 -93000.0 -0.08 9715160.0 -190982.5 -0.160593298214629 0.0389 0.11 3069934 PK04_101262 OCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N07 compound treatment 8793480.0 -372000.0 -0.32 9616880.0 -592000.0 -0.49 1.016408E7 257937.5 0.216894395341122 -0.3432 -0.549 3187836 PK04_101263 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N08 compound treatment 8652120.0 -513000.0 -0.44 1.004436E7 -165000.0 -0.14 9871680.0 -34462.5 -0.0289788150208614 -0.3507 -0.7571 3069935 PK04_101264 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N09 mock treatment 8913400.0 -252000.0 -0.22 1.026332E7 54000.0 0.04 9392120.0 -514022.5 -0.432231061126172 -0.3488 -0.7183 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N10 mock treatment 9027120.0 -138000.0 -0.12 1.018932E7 -20000.0 -0.02 1.011648E7 210337.5 0.176868523886846 0.0239 0.1119 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N11 compound treatment 9045200.0 -120000.0 -0.1 1.007328E7 -136000.0 -0.11 9759440.0 -146702.5 -0.123359147206323 -0.196 -0.9974 3187837 PK04_101265 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N12 compound treatment 8984040.0 -181000.0 -0.16 1.025108E7 41800.0 0.03 1.000724E7 101097.5 0.0850108306585864 -0.0209 -0.1157 3069935 PK04_101266 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N13 mock treatment 9258880.0 93700.0 0.08 9940560.0 -269000.0 -0.22 9068320.0 -837822.5 -0.70450789257354 -0.4889 -0.6577 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N14 mock treatment 8914240.0 -251000.0 -0.22 1.039152E7 182000.0 0.15 9694320.0 -211822.5 -0.178117230170661 -0.1403 -0.4409 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N15 compound treatment 8904360.0 -261000.0 -0.22 1.022908E7 19800.0 0.02 9945560.0 39417.5 0.0331453736985072 -0.101 -0.4439 3069936 PK04_101267 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N16 compound treatment 9492240.0 327000.0 0.28 9755440.0 -454000.0 -0.38 9425520.0 -480622.5 -0.404145680735987 -0.2882 -0.4649 3187838 PK04_101268 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N17 compound treatment 8478200.0 -687000.0 -0.59 9844880.0 -364000.0 -0.3 9680600.0 -225542.5 -0.1896540990016 -0.6254 -0.9056 3187839 PK04_101269 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N18 compound treatment 8959200.0 -206000.0 -0.18 9286120.0 -923000.0 -0.77 9151520.0 -754622.5 -0.634546705493796 -0.9109 -0.9016 3187838 PK04_101270 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N19 compound treatment 8488120.0 -677000.0 -0.58 9447080.0 -762000.0 -0.63 9483800.0 -422342.5 -0.35513921459407 -0.9066 -0.9744 3187840 PK04_101271 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N20 compound treatment 9069760.0 -95400.0 -0.08 9960440.0 -249000.0 -0.21 9395320.0 -510822.5 -0.42954024623849 -0.4146 -0.8573 3187841 PK04_101272 CC(C)(C)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N21 compound treatment 8080120.0 -1090000.0 -0.93 9579840.0 -629000.0 -0.52 9664440.0 -241702.5 -0.203242714184396 -0.958 -0.8796 3069973 PK04_101273 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N22 compound treatment 9026520.0 -139000.0 -0.12 8931520.0 -1280000.0 -1.06 9261520.0 -644622.5 -0.542049943729712 -0.9939 -0.8306 3187841 PK04_101274 CC(C)(C)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N23 compound treatment 8391120.0 -774000.0 -0.67 9498440.0 -711000.0 -0.59 8704120.0 -1202022.5 -1.0107562619779 -1.3087 -0.9719 3187842 PK04_101275 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 N24 compound treatment 7831640.0 -1330000.0 -1.15 7987560.0 -2220000.0 -1.84 8086120.0 -1820022.5 -1.53041988716157 -2.6103 -0.9827 3187843 PK04_101276 COc1ccc(cc1)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O01 compound treatment 7772280.0 -1390000.0 -1.2 8058680.0 -2150000.0 -1.78 7980400.0 -1925742.5 -1.61931768401338 -2.6571 -0.9873 3069974 PK04_101277 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O02 compound treatment 8266800.0 -898000.0 -0.77 9128480.0 -1080000.0 -0.9 9254400.0 -651742.5 -0.548037006854806 -1.2805 -0.9815 3187957 PK04_101278 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O03 compound treatment 7791880.0 -1370000.0 -1.18 9341360.0 -868000.0 -0.72 8937920.0 -968222.5 -0.8141585992466 -1.5682 -0.9766 3187958 PK04_101279 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O04 compound treatment 9137160.0 -28000.0 -0.02 9473320.0 -736000.0 -0.61 8602440.0 -1303702.5 -1.09625690503401 -0.9994 -0.7963 3069975 PK04_101280 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O05 compound treatment 8649600.0 -516000.0 -0.44 9819120.0 -390000.0 -0.32 9418960.0 -487182.5 -0.409661851255736 -0.6796 -0.9918 3187959 PK04_101281 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O06 compound treatment 9317560.0 152000.0 0.13 9760760.0 -449000.0 -0.37 9810360.0 -95782.5 -0.0805415553060763 -0.1856 -0.461 3187960 PK04_101282 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O07 compound treatment 9097800.0 -67400.0 -0.06 9788480.0 -421000.0 -0.35 9264000.0 -642142.5 -0.539964562191758 -0.5468 -0.847 3069976 PK04_101283 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O08 compound treatment 9307000.0 142000.0 0.12 1.0094E7 -115000.0 -0.1 9559840.0 -346302.5 -0.291198725825516 -0.1529 -0.4635 3187961 PK04_101284 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O09 compound treatment 9082840.0 -82400.0 -0.07 9680760.0 -529000.0 -0.44 9695680.0 -210462.5 -0.176973633843396 -0.3963 -0.8288 3069977 PK04_101285 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O10 compound treatment 8944200.0 -221000.0 -0.19 9779720.0 -430000.0 -0.36 1.062092E7 714777.5 0.601041855743888 0.0314 0.0434 3187962 PK04_101286 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O11 mock treatment 9767440.0 602000.0 0.52 1.039384E7 185000.0 0.15 9756720.0 -149422.5 -0.125646339860853 0.3151 0.5679 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O12 mock treatment 9589000.0 424000.0 0.36 1.0037E7 -172000.0 -0.14 1.091676E7 1010617.5 0.84980769211013 0.6187 0.6612 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O13 compound treatment 9405240.0 240000.0 0.21 1.04404E7 231000.0 0.19 9415560.0 -490582.5 -0.412520842073898 -0.0082 -0.0165 3187963 PK04_101287 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O14 compound treatment 9763520.0 598000.0 0.51 1.118132E7 972000.0 0.81 1.004784E7 141697.5 0.119150544546057 0.8316 0.8626 3069978 PK04_101288 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O15 compound treatment 9098240.0 -67000.0 -0.06 1.026668E7 57400.0 0.05 9781640.0 -124502.5 -0.104691618923026 -0.0662 -0.515 3187964 PK04_101289 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O16 compound treatment 9130080.0 -35100.0 -0.03 1.068968E7 480000.0 0.4 9808280.0 -97862.5 -0.0822905849830699 0.1651 0.4046 3187965 PK04_101290 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O17 compound treatment 8685600.0 -480000.0 -0.41 1.064848E7 439000.0 0.36 1.089952E7 993377.5 0.835310926902741 0.4543 0.4541 3069979 PK04_101291 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O18 compound treatment 9156840.0 -8370.0 -0.01 1.02674E7 58100.0 0.05 9966280.0 60137.5 0.050568400096251 0.0529 0.7527 3187966 PK04_101292 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O19 compound treatment 9341480.0 176000.0 0.15 9599360.0 -610000.0 -0.51 8773680.0 -1132462.5 -0.952264673356902 -0.7543 -0.6927 3187967 PK04_101293 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O20 compound treatment 9076880.0 -88300.0 -0.08 9910880.0 -298000.0 -0.25 1.00622E7 156057.5 0.131225576354532 -0.1111 -0.3825 3069980 PK04_101294 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O21 compound treatment 8439080.0 -726000.0 -0.62 9887640.0 -322000.0 -0.27 9358960.0 -547182.5 -0.460114630399782 -0.7805 -0.9511 3187968 PK04_101295 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O22 compound treatment 8204840.0 -960000.0 -0.83 9646680.0 -563000.0 -0.47 8669880.0 -1236262.5 -1.0395479812761 -1.3469 -0.9568 3069981 PK04_101296 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O23 compound treatment 7988600.0 -1180000.0 -1.01 9353520.0 -856000.0 -0.71 9229040.0 -677102.5 -0.569361714839689 -1.3232 -0.9719 3187969 PK04_101297 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 O24 compound treatment 7431520.0 -1730000.0 -1.49 7870920.0 -2340000.0 -1.94 8211160.0 -1694982.5 -1.42527629542538 -2.8043 -0.9902 3187970 PK04_101298 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P01 compound treatment 6951040.0 -2210000.0 -1.91 7447600.0 -2760000.0 -2.29 7822720.0 -2083422.5 -1.75190758760393 -3.4344 -0.9935 3069982 PK04_101299 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P02 compound treatment 7947600.0 -1220000.0 -1.05 8990920.0 -1220000.0 -1.01 8300280.0 -1605862.5 -1.35033710080342 -1.9682 -0.9912 3187843 PK04_101300 COc1ccc(cc1)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P03 compound treatment 8330080.0 -835000.0 -0.72 1.145772E7 1250000.0 1.04 8439640.0 -1466502.5 -1.23315211244485 -0.529 -0.3 3187971 PK04_101301 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P04 compound treatment 7945520.0 -1220000.0 -1.05 8909080.0 -1300000.0 -1.08 8818240.0 -1087902.5 -0.914795076045923 -1.757 -0.9975 3069983 PK04_101302 OCCOCCN(C(C(=O)N(CC=C)Cc1ccccc1)c2cccs2)C(=O)/C=C\C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P05 compound treatment 8056800.0 -1110000.0 -0.95 9258360.0 -951000.0 -0.79 9458600.0 -447542.5 -0.376329381834569 -1.2235 -0.9456 3187972 PK04_101303 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P06 compound treatment 8250480.0 -915000.0 -0.79 9204000.0 -1010000.0 -0.83 8589800.0 -1316342.5 -1.10688562384035 -1.5751 -0.9882 3187973 PK04_101304 OCCOCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P07 compound treatment 8516720.0 -648000.0 -0.56 8647720.0 -1560000.0 -1.3 8726440.0 -1179702.5 -0.991987828136314 -1.6429 -0.9527 3069985 PK04_101305 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P08 compound treatment 8303720.0 -861000.0 -0.74 9203160.0 -1010000.0 -0.83 8957960.0 -948182.5 -0.797307371012489 -1.3703 -0.9988 3187974 PK04_101306 CCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P09 compound treatment 8114440.0 -1050000.0 -0.9 8862600.0 -1350000.0 -1.12 9978200.0 72057.5 0.0605916855528681 -1.1321 -0.787 3187975 PK04_101307 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P10 compound treatment 8744280.0 -421000.0 -0.36 8912640.0 -1300000.0 -1.08 1.252016E7 2614017.5 2.19807412676952 0.4389 0.1774 3187974 PK04_101308 CCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P11 mock treatment 8622120.0 -543000.0 -0.47 9285160.0 -924000.0 -0.77 9086760.0 -819382.5 -0.68900207178327 -1.1103 -0.981 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P12 mock treatment 8446160.0 -719000.0 -0.62 8816000.0 -1390000.0 -1.16 8789640.0 -1116502.5 -0.938844234104585 -1.5667 -0.9715 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P13 compound treatment 8749000.0 -416000.0 -0.36 9478160.0 -731000.0 -0.61 8926320.0 -979822.5 -0.823912803214449 -1.0327 -0.9527 3069986 PK04_101309 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P14 compound treatment 8254280.0 -911000.0 -0.78 9363960.0 -845000.0 -0.7 1.103888E7 1132737.5 0.952495915261312 -0.3076 -0.2168 3069301 PK04_101310 CCCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P15 compound treatment 8049840.0 -1120000.0 -0.96 8219040.0 -1990000.0 -1.65 8804120.0 -1102022.5 -0.926668296737822 -2.0425 -0.9622 3187976 PK04_101311 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCCCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P16 compound treatment 7703240.0 -1460000.0 -1.26 8767280.0 -1440000.0 -1.2 8776520.0 -1129622.5 -0.949876575144083 -1.9655 -0.9932 3069301 PK04_101312 CCCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P17 compound treatment 8020760.0 -1140000.0 -0.98 8623600.0 -1590000.0 -1.32 8265680.0 -1640462.5 -1.37943153677649 -2.1246 -0.9902 3187977 PK04_101313 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P18 compound treatment 8337080.0 -828000.0 -0.71 8912520.0 -1300000.0 -1.08 9153320.0 -752822.5 -0.633033122119475 -1.3981 -0.9727 3069302 PK04_101314 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P19 compound treatment 7797400.0 -1370000.0 -1.18 8035000.0 -2170000.0 -1.8 8773600.0 -1132542.5 -0.952331943729094 -2.2709 -0.9643 3189130 PK04_101315 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P20 compound treatment 8648520.0 -517000.0 -0.44 8482880.0 -1730000.0 -1.43 8577520.0 -1328622.5 -1.11721162597184 -1.7286 -0.9244 3069302 PK04_101316 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P21 compound treatment 7965040.0 -1200000.0 -1.03 8784080.0 -1430000.0 -1.18 8622640.0 -1283502.5 -1.07927113605551 -1.9021 -0.9984 3189131 PK04_101317 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5c(Cl)cccc5CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P22 compound treatment 8171760.0 -993000.0 -0.86 8160600.0 -2050000.0 -1.7 8674440.0 -1231702.5 -1.03571357006115 -2.0728 -0.9569 3069303 PK04_101318 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P23 compound treatment 7775000.0 -1390000.0 -1.2 7680600.0 -2530000.0 -2.1 7948200.0 -1957942.5 -1.64639400882069 -2.8525 -0.9759 3069685 PK04_101319 OCc1cccc(Cl)c1N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2101 P24 compound treatment 7199560.0 -1970000.0 -1.69 7330920.0 -2880000.0 -2.39 7319880.0 -2586262.5 -2.17473551201713 -3.6109 -0.9904 3069303 PK04_101320 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A01 compound treatment 5295120.0 -4440000.0 -3.82 5485200.0 -3630000.0 -3.01 3333160.0 -6579626.4516129 -5.53267400355913 -7.1406 -0.9691 3188092 PK04_102001 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A02 compound treatment 2021320.0 -7710000.0 -6.64 3056200.0 -6060000.0 -5.03 1296200.0 -8616586.4516129 -7.2455122203134 -10.9196 -0.9892 3188093 PK04_102002 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A03 compound treatment 2742320.0 -6990000.0 -6.02 4175800.0 -4940000.0 -4.1 4114760.0 -5798026.4516129 -4.8754424672427 -8.6568 -0.9878 3069304 PK04_102003 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccccc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A04 compound treatment 1740480.0 -7990000.0 -6.88 1922640.0 -7200000.0 -5.97 2756160.0 -7156626.4516129 -6.01786156299438 -10.8933 -0.9978 3188094 PK04_102004 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A05 compound treatment 7135600.0 -2600000.0 -2.24 7662400.0 -1460000.0 -1.21 7398080.0 -2514706.4516129 -2.11456548692222 -3.2099 -0.9707 3069305 PK04_102005 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A06 compound treatment 6890680.0 -2840000.0 -2.45 6613400.0 -2510000.0 -2.08 6926400.0 -2986386.4516129 -2.51119160136661 -4.063 -0.9967 3188095 PK04_102006 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A07 compound treatment 4017560.0 -5720000.0 -4.92 3107080.0 -6010000.0 -4.99 5684800.0 -4227986.4516129 -3.5552277777874 -7.7728 -0.9894 3069306 PK04_102007 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A08 compound treatment 2064800.0 -7670000.0 -6.6 2044280.0 -7070000.0 -5.87 2383760.0 -7529026.4516129 -6.33100514554842 -10.8547 -0.9988 3188096 PK04_102008 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A09 compound treatment 5532600.0 -4200000.0 -3.62 5327640.0 -3790000.0 -3.15 5489000.0 -4423786.4516129 -3.71987201372747 -6.0515 -0.9974 3188097 PK04_102009 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A10 compound treatment 4002800.0 -5730000.0 -4.93 3554560.0 -5560000.0 -4.62 3449480.0 -6463306.4516129 -5.43486288239188 -8.651 -0.9977 3069307 PK04_102010 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A11 compound treatment 7519600.0 -2210000.0 -1.91 6679720.0 -2440000.0 -2.02 5467360.0 -4445426.4516129 -3.73806864940542 -4.4271 -0.9503 3188098 PK04_102011 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A12 compound treatment 3333120.0 -6400000.0 -5.51 2927360.0 -6190000.0 -5.14 2804480.0 -7108306.4516129 -5.97723025819037 -9.5973 -0.9981 3069308 PK04_102012 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A13 mock treatment 8921680.0 -813000.0 -0.7 7899560.0 -1220000.0 -1.01 8981280.0 -931506.451612899 -0.783284821241325 -1.4402 -0.9876 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A14 mock treatment 9058640.0 -676000.0 -0.58 7419720.0 -1700000.0 -1.41 8953800.0 -958986.451612899 -0.806392194089298 -1.6153 -0.9364 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A15 compound treatment 270080.0 -9460000.0 -8.15 227600.0 -8890000.0 -7.38 305920.0 -9606866.4516129 -8.07821852249283 -13.6253 -0.999 3188099 PK04_102013 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A16 compound treatment 1709920.0 -8020000.0 -6.91 1616840.0 -7500000.0 -6.22 2515720.0 -7397066.4516129 -6.22004266661762 -11.1717 -0.9988 3188100 PK04_102014 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A17 compound treatment 3171800.0 -6560000.0 -5.65 3474440.0 -5640000.0 -4.68 4363680.0 -5549106.4516129 -4.6661307041671 -8.6585 -0.9958 3069309 PK04_102015 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@]5(O[C@H](CCO)[C@H]([C@@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A18 compound treatment 601160.0 -9130000.0 -7.86 653400.0 -8470000.0 -7.02 1354160.0 -8558626.4516129 -7.19677483566025 -12.748 -0.9988 3188101 PK04_102016 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A19 compound treatment 156840.0 -9580000.0 -8.24 140120.0 -8980000.0 -7.45 194040.0 -9718746.4516129 -8.17229613800342 -13.7778 -0.999 3069310 PK04_102017 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A20 compound treatment 3126800.0 -6610000.0 -5.69 2950920.0 -6170000.0 -5.12 3620360.0 -6292426.4516129 -5.29117336738963 -9.2924 -0.999 3188102 PK04_102018 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@@]5(O[C@@H](CCO)[C@@H]([C@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A21 compound treatment 5146440.0 -4590000.0 -3.95 5283880.0 -3840000.0 -3.18 5958280.0 -3954506.4516129 -3.32526401044884 -6.0365 -0.9955 3188103 PK04_102019 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A22 compound treatment 229800.0 -9500000.0 -8.18 174480.0 -8940000.0 -7.42 257240.0 -9655546.4516129 -8.1191525439717 -13.6944 -0.9991 3069311 PK04_102020 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A23 compound treatment 4490920.0 -5240000.0 -4.51 4531880.0 -4590000.0 -3.81 5074600.0 -4838186.4516129 -4.06833254168235 -7.1514 -0.9975 3188104 PK04_102021 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 A24 compound treatment 8080800.0 -1650000.0 -1.42 6929840.0 -2190000.0 -1.82 7020280.0 -2892506.4516129 -2.43224981959923 -3.2745 -0.9767 3188105 PK04_102022 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B01 compound treatment 4960080.0 -4770000.0 -4.11 5405280.0 -3710000.0 -3.08 6082040.0 -3830746.4516129 -3.22119674466772 -6.0109 -0.9915 3069350 PK04_102023 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B02 compound treatment 4043000.0 -5690000.0 -4.9 5284440.0 -3830000.0 -3.18 4227040.0 -5685746.4516129 -4.78102849987114 -7.425 -0.9837 3188106 PK04_102024 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B03 compound treatment 8511840.0 -1220000.0 -1.05 8617200.0 -502000.0 -0.42 9425080.0 -487706.451612899 -0.410102431505865 -1.0847 -0.9012 3069351 PK04_102025 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCCCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B04 compound treatment 5679480.0 -4060000.0 -3.49 6935600.0 -2180000.0 -1.81 7223880.0 -2688906.4516129 -2.26104672237043 -4.3661 -0.9626 3188107 PK04_102026 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B05 compound treatment 5042560.0 -4690000.0 -4.04 7483560.0 -1640000.0 -1.36 8961760.0 -951026.451612899 -0.799698792056188 -3.5764 -0.8251 3188221 PK04_102027 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B06 compound treatment 4327640.0 -5410000.0 -4.65 4777880.0 -4340000.0 -3.6 7268040.0 -2644746.4516129 -2.22391347692041 -6.0498 -0.9618 3069352 PK04_102028 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B07 compound treatment 5655640.0 -4080000.0 -3.51 4807960.0 -4310000.0 -3.58 5462880.0 -4449906.4516129 -3.74183579024818 -6.2519 -0.9996 3188222 PK04_102029 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B08 compound treatment 8052640.0 -1680000.0 -1.45 4658440.0 -4460000.0 -3.7 5423240.0 -4489546.4516129 -3.77516825966934 -5.1517 -0.9399 3069353 PK04_102030 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B09 compound treatment 6387800.0 -3350000.0 -2.88 4376600.0 -4740000.0 -3.93 4911440.0 -5001346.4516129 -4.20553046576805 -6.3624 -0.9881 3188223 PK04_102031 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B10 compound treatment 8199160.0 -1540000.0 -1.32 6207920.0 -2910000.0 -2.42 7007120.0 -2905666.4516129 -2.44331579582482 -3.5679 -0.9693 3188224 PK04_102032 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B11 compound treatment 8310920.0 -1420000.0 -1.23 7938960.0 -1180000.0 -0.98 8659480.0 -1253306.4516129 -1.05387989338389 -1.8811 -0.9955 3069354 PK04_102033 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B12 compound treatment 7143000.0 -2590000.0 -2.23 5959560.0 -3160000.0 -2.62 6397640.0 -3515146.4516129 -2.95581512637004 -4.5075 -0.9936 3188225 PK04_102034 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B13 mock treatment 9251400.0 -483000.0 -0.42 8887480.0 -232000.0 -0.19 9867000.0 -45786.4516128991 -0.038500895516919 -0.3732 -0.812 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B14 mock treatment 9714840.0 -19700.0 -0.02 8941560.0 -178000.0 -0.15 1.048388E7 571093.548387101 0.480220944456065 0.1825 0.363 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B15 compound treatment 4762360.0 -4970000.0 -4.28 3701680.0 -5420000.0 -4.49 4650120.0 -5262666.4516129 -4.42526913653342 -7.6202 -0.9998 3188226 PK04_102035 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B16 compound treatment 9718360.0 -16100.0 -0.01 6905360.0 -2210000.0 -1.84 6869120.0 -3043666.4516129 -2.55935718785612 -2.5459 -0.8082 3069355 PK04_102036 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B17 compound treatment 7548960.0 -2190000.0 -1.88 6587680.0 -2530000.0 -2.1 7573960.0 -2338826.4516129 -1.96667157365797 -3.4339 -0.999 3188227 PK04_102037 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B18 compound treatment 3728080.0 -6010000.0 -5.17 3570520.0 -5550000.0 -4.6 3758120.0 -6154666.4516129 -5.1753337864749 -8.63 -0.9986 3069356 PK04_102038 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B19 compound treatment 8369920.0 -1360000.0 -1.17 8001880.0 -1120000.0 -0.93 9205040.0 -707746.451612899 -0.59512959022013 -1.5567 -0.9669 3188228 PK04_102039 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B20 compound treatment 3636680.0 -6100000.0 -5.25 3913920.0 -5210000.0 -4.32 4540040.0 -5372746.4516129 -4.5178331686697 -8.1314 -0.9964 3188229 PK04_102040 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B21 compound treatment 6548880.0 -3190000.0 -2.74 7415640.0 -1700000.0 -1.41 8231120.0 -1681666.4516129 -1.41407910128628 -3.2152 -0.9476 3069357 PK04_102041 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B22 compound treatment 4708280.0 -5030000.0 -4.33 4635560.0 -4480000.0 -3.72 4503920.0 -5408866.4516129 -4.54820574171441 -7.2708 -0.9965 3188230 PK04_102042 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(I)c6)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B23 compound treatment 4411080.0 -5320000.0 -4.58 4578760.0 -4540000.0 -3.77 5101040.0 -4811746.4516129 -4.04609968367287 -7.1558 -0.9967 3069358 PK04_102043 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 B24 compound treatment 7162320.0 -2570000.0 -2.21 7402240.0 -1720000.0 -1.42 7362440.0 -2550346.4516129 -2.14453443773378 -3.3385 -0.9833 3188231 PK04_102044 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C01 compound treatment 7426320.0 -2310000.0 -1.99 8338360.0 -781000.0 -0.65 6055880.0 -3856906.4516129 -3.24319415637452 -3.3933 -0.8796 3188232 PK04_102045 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C02 compound treatment 2369240.0 -7370000.0 -6.34 3673680.0 -5450000.0 -4.52 3194000.0 -6718786.4516129 -5.64969081598723 -9.5297 -0.9908 3069359 PK04_102046 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C03 compound treatment 5018000.0 -4720000.0 -4.06 7363360.0 -1760000.0 -1.46 5865680.0 -4047106.4516129 -3.40312946626115 -5.1493 -0.9373 3188233 PK04_102047 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C04 compound treatment 8754320.0 -980000.0 -0.84 8690600.0 -428000.0 -0.36 7567080.0 -2345706.4516129 -1.97245682566649 -1.8311 -0.8421 3188234 PK04_102048 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C05 compound treatment 8158960.0 -1580000.0 -1.36 8748840.0 -370000.0 -0.31 8956040.0 -956746.451612899 -0.80450862366792 -1.4247 -0.8869 3069360 PK04_102049 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C06 compound treatment 2675520.0 -7060000.0 -6.08 1616360.0 -7500000.0 -6.22 2785560.0 -7127226.4516129 -5.99313970121379 -10.5611 -0.9999 3188235 PK04_102050 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C07 compound treatment 9698760.0 -35700.0 -0.03 8836280.0 -283000.0 -0.23 9604240.0 -308546.451612899 -0.259450432981744 -0.303 -0.8629 3069393 PK04_102051 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C08 compound treatment 4623240.0 -5110000.0 -4.4 3781600.0 -5340000.0 -4.43 3636600.0 -6276186.4516129 -5.27751748183465 -8.1431 -0.9963 3188236 PK04_102052 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C09 compound treatment 2432720.0 -7300000.0 -6.28 710000.0 -8410000.0 -6.98 288840.0 -9623946.4516129 -8.09258074695583 -12.328 -0.9946 3069394 PK04_102053 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C10 compound treatment 2488920.0 -7250000.0 -6.24 2490440.0 -6630000.0 -5.5 2204680.0 -7708106.4516129 -6.48158987370035 -10.5172 -0.9976 3188352 PK04_102054 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C11 mock treatment 9840840.0 106000.0 0.09 9111680.0 -7410.0 -0.01 9978360.0 65573.5483871009 0.0551394625744302 0.0811 0.758 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C12 mock treatment 1.00026E7 268000.0 0.23 9444200.0 325000.0 0.27 1.016064E7 247853.548387101 0.208415005614042 0.4093 0.9943 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C13 compound treatment 9473800.0 -261000.0 -0.22 9036320.0 -82800.0 -0.07 1.049292E7 580133.548387101 0.487822496513768 0.1125 0.2077 3188353 PK04_102055 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C14 compound treatment 502960.0 -9230000.0 -7.95 484080.0 -8640000.0 -7.16 507640.0 -9405146.4516129 -7.90859627901054 -13.2889 -0.9989 3069395 PK04_102056 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C15 mock treatment 9824160.0 89700.0 0.08 9260480.0 141000.0 0.12 1.061088E7 698093.548387101 0.587012660310962 0.4512 0.7475 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C16 mock treatment 1.04418E7 707000.0 0.61 8877120.0 -242000.0 -0.2 1.10602E7 1147413.5483871 0.964836705727674 0.7926 0.6843 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C17 compound treatment 3832760.0 -5900000.0 -5.08 3318880.0 -5800000.0 -4.81 4347680.0 -5565106.4516129 -4.67958477860551 -8.4123 -0.9994 3188354 PK04_102057 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C18 compound treatment 7003520.0 -2730000.0 -2.35 5747960.0 -3370000.0 -2.8 7417640.0 -2495146.4516129 -2.09811788092126 -4.183 -0.9929 3069396 PK04_102058 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C19 compound treatment 2920680.0 -6810000.0 -5.86 3064440.0 -6050000.0 -5.02 3219720.0 -6693066.4516129 -5.62806339132748 -9.535 -0.9979 3188355 PK04_102059 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C20 compound treatment 3401200.0 -6330000.0 -5.45 3059880.0 -6060000.0 -5.03 3238480.0 -6674306.4516129 -5.61228848904844 -9.2893 -0.9989 3188356 PK04_102060 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C21 compound treatment 7044560.0 -2690000.0 -2.32 5165880.0 -3950000.0 -3.28 5848320.0 -4064466.4516129 -3.41772713702683 -5.2032 -0.9869 3069397 PK04_102061 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C22 compound treatment 3535440.0 -6200000.0 -5.34 3351080.0 -5770000.0 -4.78 4236120.0 -5676666.4516129 -4.77339331262734 -8.5988 -0.9986 3188357 PK04_102062 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C23 compound treatment 3769560.0 -5960000.0 -5.13 3221080.0 -5900000.0 -4.89 3798240.0 -6114546.4516129 -5.14159769482059 -8.7573 -0.9997 3188358 PK04_102063 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 C24 compound treatment 3831480.0 -5900000.0 -5.08 4212440.0 -4910000.0 -4.07 4100640.0 -5812146.4516129 -4.8873156879346 -8.1049 -0.9957 3069398 PK04_102064 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D01 compound treatment 3819240.0 -5920000.0 -5.09 5766080.0 -3350000.0 -2.78 4419720.0 -5493066.4516129 -4.61900780844656 -7.212 -0.9726 3188359 PK04_102065 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D02 compound treatment 5701480.0 -4030000.0 -3.47 6112640.0 -3010000.0 -2.49 7629520.0 -2283266.4516129 -1.91995230017058 -4.5524 -0.9716 3069399 PK04_102066 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(I)cc6)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D03 compound treatment 5767200.0 -3970000.0 -3.41 6973720.0 -2150000.0 -1.78 7325680.0 -2587106.4516129 -2.17544517375603 -4.2548 -0.9621 3188360 PK04_102067 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D04 compound treatment 9068800.0 -666000.0 -0.57 9069520.0 -49600.0 -0.04 9516960.0 -395826.451612899 -0.332842409043283 -0.5467 -0.8235 3188361 PK04_102068 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D05 compound treatment 6909840.0 -2820000.0 -2.43 5371400.0 -3750000.0 -3.11 7494240.0 -2418546.4516129 -2.03370649954736 -4.3727 -0.9849 3069400 PK04_102069 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D06 compound treatment 9686920.0 -47600.0 -0.04 8800200.0 -319000.0 -0.26 9645160.0 -267626.451612899 -0.225041637605505 -0.3063 -0.8759 3188362 PK04_102070 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D07 compound treatment 9308560.0 -426000.0 -0.37 8083520.0 -1040000.0 -0.86 9365880.0 -546906.451612899 -0.45988250692799 -0.9732 -0.9347 3188363 PK04_102071 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D08 compound treatment 1.030112E7 567000.0 0.49 9115160.0 -3930.0 0.0 1.017192E7 259133.548387101 0.217900128093122 0.4055 0.7591 3069401 PK04_102072 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D09 compound treatment 4070800.0 -5660000.0 -4.87 5062520.0 -4060000.0 -3.37 4485640.0 -5427146.4516129 -4.5635770217603 -7.3919 -0.9886 3188364 PK04_102073 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D10 compound treatment 1.0002E7 267000.0 0.23 9151240.0 32100.0 0.03 1.009868E7 185893.548387101 0.15631410235129 0.2386 0.8534 3069402 PK04_102074 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D11 mock treatment 9888560.0 154000.0 0.13 9407280.0 288000.0 0.24 1.053972E7 626933.548387101 0.527175664246124 0.5189 0.8739 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D12 mock treatment 9918880.0 184000.0 0.16 9944520.0 825000.0 0.68 1.10482E7 1135413.5483871 0.954746149898865 1.0382 0.8757 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D13 compound treatment 9077360.0 -657000.0 -0.57 9677120.0 558000.0 0.46 1.064588E7 733093.548387101 0.616443448144989 0.2966 0.3103 3069403 PK04_102075 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D14 compound treatment 9250160.0 -484000.0 -0.42 8710880.0 -408000.0 -0.34 1.009184E7 179053.548387101 0.150562485528869 -0.3493 -0.6262 3188365 PK04_102076 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D15 mock treatment 1.033084E7 596000.0 0.51 8996160.0 -123000.0 -0.1 1.038828E7 475493.548387101 0.399832849686552 0.4683 0.7111 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D16 mock treatment 9984680.0 250000.0 0.22 8914600.0 -204000.0 -0.17 1.019148E7 278693.548387101 0.234347734094081 0.1617 0.4483 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D17 compound treatment 9572920.0 -162000.0 -0.14 8892480.0 -227000.0 -0.19 9283320.0 -629466.451612899 -0.529305531030198 -0.4944 -0.8544 3188366 PK04_102077 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D18 compound treatment 9734920.0 413.0 0.0 9307920.0 189000.0 0.16 1.085164E7 938853.548387101 0.78946284542297 0.5464 0.6789 3069404 PK04_102078 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D19 compound treatment 8545920.0 -1190000.0 -1.02 6779600.0 -2340000.0 -1.94 9292880.0 -619906.451612899 -0.521266721553246 -2.0121 -0.8923 3188367 PK04_102079 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D20 compound treatment 4891400.0 -4840000.0 -4.17 5575280.0 -3540000.0 -2.94 6060960.0 -3851826.4516129 -3.23892248774033 -5.9738 -0.9887 3069405 PK04_102080 COc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D21 compound treatment 6805880.0 -2930000.0 -2.52 6405080.0 -2710000.0 -2.25 8212160.0 -1700626.4516129 -1.4300221794958 -3.5807 -0.9757 3188368 PK04_102081 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D22 compound treatment 9635160.0 -99300.0 -0.09 9106080.0 -13000.0 -0.01 9612040.0 -300746.451612899 -0.252891571693018 -0.2016 -0.7546 3069440 PK04_102082 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D23 compound treatment 7446280.0 -2290000.0 -1.97 7122840.0 -2000000.0 -1.66 8375760.0 -1537026.4516129 -1.29245426836304 -2.8393 -0.9861 3188485 PK04_102083 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 D24 compound treatment 8906920.0 -828000.0 -0.71 8568040.0 -551000.0 -0.46 8993760.0 -919026.451612899 -0.772790643179363 -1.1213 -0.9784 3069441 PK04_102084 O[C@H](CC=C)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E01 mock treatment 8808440.0 -926000.0 -0.8 8730400.0 -389000.0 -0.32 7128680.0 -2784106.4516129 -2.34109846527898 -1.998 -0.8011 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E02 mock treatment 8933120.0 -801000.0 -0.69 9042200.0 -76900.0 -0.06 8542280.0 -1370506.4516129 -1.15243098864526 -1.1004 -0.8184 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E03 compound treatment 6031960.0 -3700000.0 -3.19 6085600.0 -3030000.0 -2.52 5737160.0 -4175626.4516129 -3.51119931918769 -5.3199 -0.991 3069442 PK04_102085 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E04 compound treatment 7175800.0 -2560000.0 -2.2 5664560.0 -3450000.0 -2.87 5948840.0 -3963946.4516129 -3.3332019143675 -4.8504 -0.9865 3188486 PK04_102086 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E05 compound treatment 5448280.0 -4290000.0 -3.69 4074960.0 -5040000.0 -4.18 4127600.0 -5785186.4516129 -4.86464557250587 -7.3543 -0.9936 3188487 PK04_102087 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E06 compound treatment 9551560.0 -183000.0 -0.16 8680920.0 -438000.0 -0.36 1.0014E7 101213.548387101 0.0851084133859935 -0.2516 -0.6211 3069443 PK04_102088 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E07 compound treatment 7070800.0 -2660000.0 -2.29 4545920.0 -4570000.0 -3.79 6924360.0 -2988426.4516129 -2.51290699585751 -4.9647 -0.9744 3188488 PK04_102089 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E08 compound treatment 6405680.0 -3330000.0 -2.86 4234200.0 -4880000.0 -4.05 4781920.0 -5130866.4516129 -4.314441198347 -6.4846 -0.9861 3188489 PK04_102090 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E09 mock treatment 9883360.0 149000.0 0.13 9573880.0 455000.0 0.38 9214920.0 -697866.451612899 -0.58682169925441 -0.047 -0.0663 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E10 mock treatment 1.065544E7 921000.0 0.79 1.017464E7 1060000.0 0.88 9676400.0 -236386.451612899 -0.198772557264505 0.8484 0.7084 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E11 compound treatment 8005600.0 -1730000.0 -1.49 5650200.0 -3470000.0 -2.88 5851640.0 -4061146.4516129 -3.41493541658086 -4.4921 -0.9543 3069444 PK04_102091 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E12 compound treatment 4021040.0 -5710000.0 -4.92 4210440.0 -4910000.0 -4.07 5289000.0 -4623786.4516129 -3.88804794420762 -7.4347 -0.9946 3188490 PK04_102092 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E13 compound treatment 8794200.0 -940000.0 -0.81 7271640.0 -1850000.0 -1.53 9903280.0 -9506.45161289908 -0.00799378172781927 -1.3567 -0.7828 3069445 PK04_102093 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E14 compound treatment 3441000.0 -6290000.0 -5.42 3404120.0 -5710000.0 -4.74 5704080.0 -4208706.4516129 -3.53901561808911 -7.9076 -0.9858 3188491 PK04_102094 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E15 compound treatment 2471880.0 -7260000.0 -6.25 1693880.0 -7430000.0 -6.16 4185600.0 -5727186.4516129 -4.81587455266663 -9.9455 -0.9935 3188492 PK04_102095 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E16 compound treatment 8717160.0 -1020000.0 -0.88 6759440.0 -2360000.0 -1.96 1.031544E7 402653.548387101 0.33858317580568 -1.4402 -0.6634 3069446 PK04_102096 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E17 mock treatment 1.052192E7 787000.0 0.68 9132600.0 13500.0 0.01 1.049412E7 581333.548387101 0.488831552096649 0.68 0.8137 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E18 mock treatment 1.004912E7 315000.0 0.27 8528880.0 -590000.0 -0.49 9565680.0 -347106.451612899 -0.291874752378318 -0.2949 -0.4673 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E19 compound treatment 3220640.0 -6510000.0 -5.61 3275080.0 -5840000.0 -4.85 8625720.0 -1287066.4516129 -1.08226799044894 -6.6605 -0.8892 3188493 PK04_102097 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E20 compound treatment 8750240.0 -984000.0 -0.85 7978960.0 -1140000.0 -0.95 9233680.0 -679106.451612899 -0.571046796975372 -1.3648 -0.9803 3188494 PK04_102098 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E21 compound treatment 4564240.0 -5170000.0 -4.45 4132400.0 -4990000.0 -4.14 4482040.0 -5430746.4516129 -4.56660418850894 -7.594 -0.9991 3069448 PK04_102099 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E22 compound treatment 3916800.0 -5820000.0 -5.01 3030240.0 -6090000.0 -5.05 3447480.0 -6465306.4516129 -5.43654464169668 -8.9458 -0.9993 3188495 PK04_102100 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E23 compound treatment 4020840.0 -5710000.0 -4.92 3924040.0 -5200000.0 -4.31 4162480.0 -5750306.4516129 -4.83531569023013 -8.1189 -0.9984 3069450 PK04_102101 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 E24 compound treatment 7550600.0 -2180000.0 -1.88 8496360.0 -623000.0 -0.52 8227280.0 -1685506.4516129 -1.4173080791515 -2.2017 -0.9135 3188496 PK04_102102 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F01 mock treatment 8426960.0 -1310000.0 -1.13 8288880.0 -830000.0 -0.69 9574880.0 -337906.451612899 -0.284138659576231 -1.2114 -0.8976 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F02 mock treatment 9595880.0 -139000.0 -0.12 9554400.0 435000.0 0.36 9215480.0 -697306.451612899 -0.586350806649066 -0.1989 -0.2846 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F03 compound treatment 6703040.0 -3030000.0 -2.61 8594760.0 -524000.0 -0.43 9743800.0 -168986.451612899 -0.142097268692693 -1.8395 -0.6945 3188497 PK04_102103 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F04 compound treatment 8228280.0 -1510000.0 -1.3 8954760.0 -164000.0 -0.14 9739720.0 -173066.451612899 -0.145528057674488 -0.9112 -0.6947 3069264 PK04_102104 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F05 compound treatment 8474520.0 -1260000.0 -1.08 8681600.0 -437000.0 -0.36 8850520.0 -1062266.4516129 -0.893238244589249 -1.3513 -0.9313 3069265 PK04_102105 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F06 compound treatment 7852720.0 -1880000.0 -1.62 7354240.0 -1760000.0 -1.46 8286760.0 -1626026.4516129 -1.3672925574267 -2.5697 -0.9976 3188498 PK04_102106 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F07 compound treatment 2313320.0 -7420000.0 -6.39 2027800.0 -7090000.0 -5.88 2281200.0 -7631586.4516129 -6.41724576269864 -10.7889 -0.9992 3188499 PK04_102107 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F08 compound treatment 1.049432E7 760000.0 0.65 9342920.0 224000.0 0.19 1.026196E7 349173.548387101 0.293612931995287 0.6543 0.8836 3069441 PK04_102108 O[C@H](CC=C)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F09 mock treatment 9744920.0 10400.0 0.01 9678200.0 559000.0 0.46 1.077632E7 863533.548387101 0.726127790004145 0.6922 0.8033 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F10 mock treatment 1.038464E7 650000.0 0.56 9982680.0 864000.0 0.72 1.100732E7 1094533.5483871 0.920370989708722 1.268 0.9802 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F11 compound treatment 5433280.0 -4300000.0 -3.7 4050200.0 -5070000.0 -4.21 4992080.0 -4920706.4516129 -4.13772193059846 -6.9539 -0.9985 3188500 PK04_102109 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F12 compound treatment 1.020756E7 473000.0 0.41 8819280.0 -300000.0 -0.25 1.098224E7 1069453.5483871 0.89928172802651 0.6107 0.5999 3069270 PK04_102110 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F13 compound treatment 8077080.0 -1660000.0 -1.43 5837960.0 -3280000.0 -2.72 6125200.0 -3787586.4516129 -3.1849043788701 -4.2339 -0.9566 3188501 PK04_102111 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F14 compound treatment 8873720.0 -861000.0 -0.74 8213720.0 -905000.0 -0.75 9577760.0 -335026.451612899 -0.281716926177316 -1.024 -0.9378 3188502 PK04_102112 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F15 compound treatment 9285880.0 -449000.0 -0.39 8573080.0 -546000.0 -0.45 9403720.0 -509066.451612899 -0.428063620881146 -0.7316 -0.9979 3188623 PK04_102113 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F16 compound treatment 9877440.0 143000.0 0.12 9109480.0 -9610.0 -0.01 1.06638E7 751013.548387101 0.631512011516011 0.431 0.6699 3069312 PK04_102114 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F17 mock treatment 1.014628E7 412000.0 0.35 9323320.0 204000.0 0.17 9707880.0 -204906.451612899 -0.172301665806929 0.2029 0.4731 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F18 mock treatment 9682760.0 -51700.0 -0.04 9255920.0 137000.0 0.11 9925360.0 12573.5483871009 0.0105728409971896 0.0459 0.3752 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F19 compound treatment 5745720.0 -3990000.0 -3.43 5370400.0 -3750000.0 -3.11 7409080.0 -2503706.4516129 -2.10531581074581 -4.9929 -0.9813 3188624 PK04_102115 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F20 compound treatment 9799520.0 65000.0 0.06 9438240.0 319000.0 0.26 9938120.0 25333.5483871009 0.0213024653618234 0.1975 0.7275 3069314 PK04_102116 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F21 compound treatment 8586560.0 -1150000.0 -0.99 7957960.0 -1160000.0 -0.96 8980960.0 -931826.451612899 -0.783553902730093 -1.5789 -0.995 3069316 PK04_102117 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F22 compound treatment 9170840.0 -564000.0 -0.49 7961280.0 -1160000.0 -0.96 9405160.0 -507626.451612899 -0.426852754181688 -1.0811 -0.9339 3188625 PK04_102118 O[C@@H](CC=C)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F23 compound treatment 7817800.0 -1920000.0 -1.65 6920840.0 -2200000.0 -1.82 7441360.0 -2471426.4516129 -2.07817221556631 -3.2051 -0.9955 3188626 PK04_102119 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 F24 compound treatment 8985760.0 -749000.0 -0.64 8249560.0 -870000.0 -0.72 8877880.0 -1034906.4516129 -0.870231777299564 -1.2909 -0.9922 3069318 PK04_102120 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G01 compound treatment 5076680.0 -4660000.0 -4.01 6355520.0 -2760000.0 -2.29 3815400.0 -6097386.4516129 -5.12716819998539 -6.5982 -0.9562 3069320 PK04_102121 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO)nn2)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G02 compound treatment 7998720.0 -1740000.0 -1.49 8245560.0 -874000.0 -0.72 7632440.0 -2280346.4516129 -1.91749693158557 -2.3879 -0.9414 3188627 PK04_102122 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G03 mock treatment 8694760.0 -1040000.0 -0.89 9053200.0 -65900.0 -0.05 8066440.0 -1846346.4516129 -1.55255516244364 -1.4446 -0.8058 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G04 mock treatment 9358160.0 -376000.0 -0.32 9160000.0 40900.0 0.03 8771080.0 -1141706.4516129 -0.960037724175966 -0.7217 -0.7119 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G05 compound treatment 8416960.0 -1320000.0 -1.13 8177800.0 -941000.0 -0.78 8637320.0 -1275466.4516129 -1.07251378648109 -1.7247 -0.9882 3069321 PK04_102123 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G06 compound treatment 1863760.0 -7870000.0 -6.77 1027680.0 -8090000.0 -6.71 2170120.0 -7742666.4516129 -6.51065067448732 -11.5452 -0.9999 3188628 PK04_102124 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G07 compound treatment 8514760.0 -1220000.0 -1.05 7546320.0 -1570000.0 -1.3 7807960.0 -2104826.4516129 -1.76990573499619 -2.3812 -0.9773 3069362 PK04_102125 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4ccccc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G08 compound treatment 4179640.0 -5550000.0 -4.78 3565840.0 -5550000.0 -4.61 3962320.0 -5950466.4516129 -5.00362616145467 -8.3088 -0.9994 3188629 PK04_102126 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G09 compound treatment 1296600.0 -8440000.0 -7.26 704040.0 -8420000.0 -6.98 920360.0 -8992426.4516129 -7.5615484288717 -12.5888 -0.9995 3188630 PK04_102127 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G10 compound treatment 8580480.0 -1150000.0 -0.99 6723880.0 -2400000.0 -1.99 7319440.0 -2593346.4516129 -2.18069226278701 -2.9796 -0.9572 3188631 PK04_102128 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G11 compound treatment 563000.0 -9170000.0 -7.89 280360.0 -8840000.0 -7.33 369040.0 -9543746.4516129 -8.02514219883329 -13.4239 -0.9992 3069365 PK04_102129 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G12 compound treatment 9767600.0 33100.0 0.03 8883760.0 -235000.0 -0.2 1.119472E7 1281933.5483871 1.07795183656862 0.5261 0.4801 3188632 PK04_102130 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G13 compound treatment 3665080.0 -6070000.0 -5.22 3729480.0 -5390000.0 -4.47 4965840.0 -4946946.4516129 -4.15978661267745 -7.9989 -0.9954 3069368 PK04_102131 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccccc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G14 compound treatment 4319320.0 -5420000.0 -4.66 2636360.0 -6480000.0 -5.38 6764840.0 -3147946.4516129 -2.64704411800848 -7.3239 -0.9646 3069370 PK04_102132 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G15 compound treatment 6785080.0 -2950000.0 -2.54 6531400.0 -2590000.0 -2.15 9443000.0 -469786.451612899 -0.395033868134843 -2.933 -0.8761 3188633 PK04_102133 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G16 compound treatment 3662800.0 -6070000.0 -5.23 3285920.0 -5830000.0 -4.84 4333040.0 -5579746.4516129 -4.69189525671666 -8.5197 -0.999 3188634 PK04_102134 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G17 compound treatment 439520.0 -9290000.0 -8.0 466520.0 -8650000.0 -7.18 599920.0 -9312866.4516129 -7.830999904687 -13.284 -0.9989 3188635 PK04_102135 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G18 compound treatment 9642640.0 -91900.0 -0.08 9303200.0 184000.0 0.15 9628360.0 -284426.451612899 -0.239168415765838 -0.0956 -0.3244 3069408 PK04_102136 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G19 mock treatment 9569120.0 -165000.0 -0.14 9904560.0 785000.0 0.65 1.03858E7 473013.548387101 0.397747468148598 0.5237 0.6743 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G20 mock treatment 9908480.0 174000.0 0.15 9039760.0 -79300.0 -0.07 9775120.0 -137666.451612899 -0.115760917979501 -0.0184 -0.0918 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G21 compound treatment 1170440.0 -8560000.0 -7.37 1178480.0 -7940000.0 -6.59 1321720.0 -8591066.4516129 -7.22405297158413 -12.2294 -0.9988 3188636 PK04_102137 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G22 compound treatment 1143800.0 -8590000.0 -7.39 743200.0 -8380000.0 -6.95 1003200.0 -8909586.4516129 -7.49188995846682 -12.6057 -0.9995 3188637 PK04_102138 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G23 compound treatment 8920640.0 -814000.0 -0.7 8933480.0 -186000.0 -0.15 9165840.0 -746946.451612899 -0.628092072594239 -0.8559 -0.8978 3069412 PK04_102139 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 G24 compound treatment 4805760.0 -4930000.0 -4.24 3784440.0 -5330000.0 -4.43 4841960.0 -5070826.4516129 -4.26395478401686 -7.4659 -0.9998 3188638 PK04_102140 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H01 compound treatment 4330680.0 -5400000.0 -4.65 5302160.0 -3820000.0 -3.17 6769880.0 -3142906.4516129 -2.64280608456038 -6.0391 -0.9715 3188639 PK04_102141 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H02 compound treatment 7770280.0 -1960000.0 -1.69 8407600.0 -711000.0 -0.59 8282360.0 -1630426.4516129 -1.37099242789727 -2.1083 -0.9349 3069414 PK04_102142 CSc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H03 mock treatment 8943080.0 -791000.0 -0.68 9061120.0 -58000.0 -0.05 9073960.0 -838826.451612899 -0.705352095056822 -0.8283 -0.8437 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H04 mock treatment 9732200.0 -2310.0 0.0 8708640.0 -410000.0 -0.34 1.03768E7 464013.548387101 0.390179551276991 0.0275 0.0532 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H05 compound treatment 5995680.0 -3740000.0 -3.22 6456600.0 -2660000.0 -2.21 7829080.0 -2083706.4516129 -1.75214635673749 -4.1446 -0.9688 3188755 PK04_102143 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H06 compound treatment 9134240.0 -600000.0 -0.52 8771560.0 -348000.0 -0.29 9978600.0 65813.5483871009 0.0553412736910064 -0.4328 -0.7283 3188362 PK04_102144 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H07 compound treatment 7609280.0 -2130000.0 -1.83 5745160.0 -3370000.0 -2.8 6349080.0 -3563706.4516129 -2.99664824229062 -4.4021 -0.9804 3188756 PK04_102145 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H08 compound treatment 1.079808E7 1060000.0 0.92 8636680.0 -482000.0 -0.4 9801080.0 -111706.451612899 -0.0939316822031775 0.2432 0.2424 3069452 PK04_102146 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H09 compound treatment 7837040.0 -1900000.0 -1.63 5561720.0 -3560000.0 -2.95 6236480.0 -3676306.4516129 -3.09133129115095 -4.4314 -0.9686 3188757 PK04_102147 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H10 compound treatment 7457560.0 -2280000.0 -1.96 5041840.0 -4080000.0 -3.38 5218040.0 -4694746.4516129 -3.94771676434198 -5.3634 -0.9654 3069454 PK04_102148 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H11 compound treatment 5530400.0 -4200000.0 -3.62 2957000.0 -6160000.0 -5.11 4026320.0 -5886466.4516129 -4.94980986370102 -7.8981 -0.9894 3188758 PK04_102149 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H12 compound treatment 1.021588E7 481000.0 0.41 8626640.0 -492000.0 -0.41 1.074876E7 835973.548387101 0.70295314678398 0.4092 0.4484 3069456 PK04_102150 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H13 compound treatment 7599000.0 -2140000.0 -1.84 3943920.0 -5180000.0 -4.29 4727120.0 -5185666.4516129 -4.36052140329856 -6.0573 -0.948 3188759 PK04_102151 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H14 compound treatment 6703120.0 -3030000.0 -2.61 6910480.0 -2210000.0 -1.83 6921560.0 -2991226.4516129 -2.51526145888423 -4.0163 -0.989 3069458 PK04_102152 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H15 compound treatment 9140480.0 -594000.0 -0.51 8655880.0 -463000.0 -0.38 1.013552E7 222733.548387101 0.187292108745734 -0.4089 -0.6136 3188760 PK04_102153 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H16 compound treatment 9963440.0 229000.0 0.2 9272080.0 153000.0 0.13 1.009196E7 179173.548387101 0.150663391087157 0.274 0.9835 3069460 PK04_102154 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H17 compound treatment 4195120.0 -5540000.0 -4.77 3902800.0 -5220000.0 -4.33 3909840.0 -6002946.4516129 -5.04775552561266 -8.1651 -0.998 3188761 PK04_102155 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H18 compound treatment 5145600.0 -4590000.0 -3.95 5287800.0 -3830000.0 -3.18 4245400.0 -5667386.4516129 -4.76558994945306 -6.8666 -0.9869 3069461 PK04_102156 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H19 mock treatment 9609920.0 -125000.0 -0.11 9180280.0 61200.0 0.05 1.05806E7 667813.548387101 0.561550824436267 0.2916 0.5081 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H20 mock treatment 1.01662E7 432000.0 0.37 1.031272E7 1190000.0 0.99 9972880.0 60093.5483871009 0.050531442079274 0.8154 0.7701 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H21 compound treatment 7411400.0 -2320000.0 -2.0 6786040.0 -2330000.0 -1.94 6151000.0 -3761786.4516129 -3.16320968383816 -4.098 -0.9727 3188762 PK04_102157 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H22 compound treatment 9001080.0 -733000.0 -0.63 7994720.0 -1120000.0 -0.93 8503440.0 -1409346.4516129 -1.18509075434451 -1.5872 -0.9708 3069504 PK04_102158 O[C@H](CC=C)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H23 compound treatment 5077280.0 -4660000.0 -4.01 6528320.0 -2590000.0 -2.15 6361520.0 -3551266.4516129 -2.98618769941475 -5.2791 -0.9703 3188763 PK04_102159 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 H24 compound treatment 8644400.0 -1090000.0 -0.94 8218640.0 -900000.0 -0.75 8944920.0 -967866.451612899 -0.813859205402617 -1.4428 -0.9955 3069401 PK04_102160 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I01 compound treatment 5261960.0 -4470000.0 -3.85 7418480.0 -1700000.0 -1.41 3628080.0 -6284706.4516129 -5.2846817764731 -6.088 -0.9102 3069507 PK04_102161 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I02 compound treatment 5533240.0 -4200000.0 -3.62 7532200.0 -1590000.0 -1.32 4444520.0 -5468266.4516129 -4.59815399306702 -5.5024 -0.9177 3188764 PK04_102162 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I03 compound treatment 8403560.0 -1330000.0 -1.15 8708160.0 -411000.0 -0.34 7757600.0 -2155186.4516129 -1.81225243429109 -1.9045 -0.8773 3188765 PK04_102163 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I04 compound treatment 1363000.0 -8370000.0 -7.2 1988600.0 -7130000.0 -5.92 1738520.0 -8174266.4516129 -6.87357433246349 -11.5434 -0.9967 3069594 PK04_102164 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I05 mock treatment 9365240.0 -369000.0 -0.32 9171840.0 52700.0 0.04 9273120.0 -639666.451612899 -0.537882503484685 -0.4688 -0.7485 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I06 mock treatment 9524960.0 -210000.0 -0.18 9045240.0 -73900.0 -0.06 9833320.0 -79466.4516128991 -0.0668217222097768 -0.1781 -0.8822 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I07 compound treatment 9636600.0 -97900.0 -0.08 8909840.0 -209000.0 -0.17 8831760.0 -1081026.4516129 -0.909013146868287 -0.6737 -0.725 3188766 PK04_102165 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I08 compound treatment 9666200.0 -68300.0 -0.06 8494160.0 -625000.0 -0.52 8490280.0 -1422506.4516129 -1.1961567305701 -1.0239 -0.7846 3188767 PK04_102166 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I09 compound treatment 1.028152E7 547000.0 0.47 8852960.0 -266000.0 -0.22 1.019724E7 284453.548387101 0.23919120089191 0.2824 0.4935 3069598 PK04_102167 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I10 compound treatment 6121960.0 -3610000.0 -3.11 4366560.0 -4750000.0 -3.94 4806600.0 -5106186.4516129 -4.29368828852575 -6.5502 -0.9915 3188768 PK04_102168 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I11 compound treatment 1317640.0 -8420000.0 -7.24 944680.0 -8170000.0 -6.78 865200.0 -9047586.4516129 -7.60793135049813 -12.4899 -0.9989 3188769 PK04_102169 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I12 compound treatment 3539520.0 -6190000.0 -5.33 3172800.0 -5950000.0 -4.93 3465440.0 -6447346.4516129 -5.42144244313956 -9.0563 -0.9992 3069636 PK04_102170 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I13 compound treatment 4168440.0 -5570000.0 -4.79 2774480.0 -6340000.0 -5.26 4937280.0 -4975506.4516129 -4.18380213555002 -8.22 -0.9957 3188770 PK04_102171 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I14 compound treatment 2857640.0 -6880000.0 -5.92 2591280.0 -6530000.0 -5.42 3163200.0 -6749586.4516129 -5.67558990928117 -9.8204 -0.9993 3188771 PK04_102172 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I15 compound treatment 9689960.0 -44500.0 -0.04 8312320.0 -807000.0 -0.67 1.006688E7 154093.548387101 0.129574129404946 -0.3337 -0.4888 3069640 PK04_102173 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I16 compound treatment 5366240.0 -4370000.0 -3.76 3197160.0 -5920000.0 -4.91 5910600.0 -4002186.4516129 -3.36535715227531 -6.9499 -0.9869 3188888 PK04_102174 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I17 compound treatment 8942040.0 -792000.0 -0.68 8172280.0 -947000.0 -0.79 8681680.0 -1231106.4516129 -1.03521236510059 -1.4449 -0.9846 3069645 PK04_102175 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I18 compound treatment 8323040.0 -1410000.0 -1.21 7482360.0 -1640000.0 -1.36 8256800.0 -1655986.4516129 -1.39248531181263 -2.2892 -0.9983 3188889 PK04_102176 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I19 compound treatment 3654920.0 -6080000.0 -5.23 3081760.0 -6040000.0 -5.01 4022640.0 -5890146.4516129 -4.95290430082185 -8.772 -0.9997 3069647 PK04_102177 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I20 compound treatment 3467560.0 -6270000.0 -5.39 3167240.0 -5950000.0 -4.94 3626640.0 -6286146.4516129 -5.28589264317256 -9.0165 -0.9993 3188890 PK04_102178 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I21 mock treatment 9571880.0 -163000.0 -0.14 8628680.0 -490000.0 -0.41 9656040.0 -256746.451612899 -0.215892866987384 -0.4403 -0.9148 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I22 mock treatment 9241600.0 -493000.0 -0.42 8781080.0 -338000.0 -0.28 9498360.0 -414426.451612899 -0.348482770577937 -0.608 -0.9863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I23 compound treatment 1087240.0 -8650000.0 -7.44 1015200.0 -8100000.0 -6.72 1022560.0 -8890226.4516129 -7.47561052839634 -12.4942 -0.9988 3188891 PK04_102179 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 I24 compound treatment 1917920.0 -7820000.0 -6.73 2691600.0 -6430000.0 -5.33 2707000.0 -7205786.4516129 -6.0591992067064 -10.4607 -0.9956 3069706 PK04_102180 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J01 compound treatment 3866680.0 -5870000.0 -5.05 4485000.0 -4630000.0 -3.84 3936440.0 -5976346.4516129 -5.0253881268588 -8.0366 -0.9927 3188892 PK04_102181 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J02 compound treatment 8491920.0 -1240000.0 -1.07 8721680.0 -397000.0 -0.33 9069760.0 -843026.451612899 -0.708883789596905 -1.217 -0.9187 3069707 PK04_102182 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J03 compound treatment 4084720.0 -5650000.0 -4.86 3867960.0 -5250000.0 -4.36 4501840.0 -5410946.4516129 -4.54995477139141 -7.9493 -0.999 3188893 PK04_102183 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J04 compound treatment 9204040.0 -530000.0 -0.46 9920200.0 801000.0 0.66 9759160.0 -153626.451612899 -0.129181357231818 0.0455 0.0558 3069711 PK04_102184 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J05 mock treatment 9892720.0 158000.0 0.14 9188960.0 69900.0 0.06 9825000.0 -87786.4516128991 -0.0738178409177512 0.0695 0.42 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J06 mock treatment 1.035688E7 622000.0 0.54 9723560.0 604000.0 0.5 1.020468E7 291893.548387101 0.245447345505771 0.7405 0.9571 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J07 compound treatment 9811200.0 76700.0 0.07 8385800.0 -733000.0 -0.61 9742760.0 -170026.451612899 -0.14297178353119 -0.3956 -0.6296 3188894 PK04_102185 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J08 compound treatment 6370000.0 -3360000.0 -2.9 3009880.0 -6110000.0 -5.07 2821200.0 -7091586.4516129 -5.96317075040223 -8.0407 -0.9636 3069714 PK04_102186 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J09 compound treatment 6708240.0 -3030000.0 -2.6 5354640.0 -3760000.0 -3.12 6406720.0 -3506066.4516129 -2.94817993912624 -5.0089 -0.9972 3188895 PK04_102187 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J10 compound treatment 1.026344E7 529000.0 0.46 9192440.0 73300.0 0.06 1.016816E7 255373.548387101 0.214738420600095 0.4219 0.8322 3069716 PK04_102188 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J11 compound treatment 5045080.0 -4690000.0 -4.04 4400680.0 -4720000.0 -3.91 4429080.0 -5483706.4516129 -4.61113717490009 -7.2523 -0.9974 3188896 PK04_102189 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J12 compound treatment 6935000.0 -2800000.0 -2.41 3993240.0 -5130000.0 -4.25 5344160.0 -4568626.4516129 -3.8416650225812 -6.0641 -0.9755 3069744 PK04_102190 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J13 compound treatment 7749760.0 -1980000.0 -1.71 6745040.0 -2370000.0 -1.97 7402040.0 -2510746.4516129 -2.11123560349871 -3.3422 -0.9963 3188897 PK04_102191 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J14 compound treatment 1.024008E7 506000.0 0.44 9930840.0 812000.0 0.67 1.089168E7 978893.548387101 0.823131666705097 1.1152 0.9706 3069746 PK04_102192 OCCOc1ccc(cc1)[C@@H](O)CC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J15 compound treatment 7796520.0 -1940000.0 -1.67 7567840.0 -1550000.0 -1.29 7065800.0 -2846986.4516129 -2.39397297782194 -3.0881 -0.9684 3069749 PK04_102193 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J16 compound treatment 9549840.0 -185000.0 -0.16 9192240.0 73100.0 0.06 9324840.0 -587946.451612899 -0.494392207862518 -0.3422 -0.6544 3188898 PK04_102194 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J17 compound treatment 7975520.0 -1760000.0 -1.51 7427360.0 -1690000.0 -1.4 8003640.0 -1909146.4516129 -1.60536240461441 -2.6111 -0.9985 3188899 PK04_102195 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J18 compound treatment 9542960.0 -192000.0 -0.16 9589560.0 470000.0 0.39 9148560.0 -764226.451612899 -0.642622472987725 -0.2409 -0.3129 3069504 PK04_102196 O[C@H](CC=C)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J19 compound treatment 8446800.0 -1290000.0 -1.11 8440080.0 -679000.0 -0.56 8237600.0 -1675186.4516129 -1.40863020113873 -1.7783 -0.9465 3188900 PK04_102197 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J20 compound treatment 1.044112E7 707000.0 0.61 9060000.0 -59100.0 -0.05 8828880.0 -1083906.4516129 -0.911434880267201 -0.2034 -0.1855 3069264 PK04_102198 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J21 mock treatment 9672680.0 -61800.0 -0.05 8993080.0 -126000.0 -0.1 9766960.0 -145826.451612899 -0.122622495943092 -0.1619 -0.9539 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J22 mock treatment 9499160.0 -235000.0 -0.2 8812520.0 -307000.0 -0.25 9518200.0 -394586.451612899 -0.331799718274306 -0.4553 -0.9802 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J23 compound treatment 8558920.0 -1180000.0 -1.01 7968840.0 -1150000.0 -0.95 7053760.0 -2859026.4516129 -2.40409716883685 -2.5231 -0.9084 3069786 PK04_102199 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 J24 compound treatment 8394720.0 -1340000.0 -1.15 7903280.0 -1220000.0 -1.01 7757520.0 -2155266.4516129 -1.81231970466329 -2.2944 -0.9669 3188901 PK04_102200 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K01 compound treatment 6883560.0 -2850000.0 -2.45 7119680.0 -2000000.0 -1.66 4741760.0 -5171026.4516129 -4.34821092518742 -4.8847 -0.9285 3069787 PK04_102201 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(CCO)nn2)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K02 compound treatment 547920.0 -9190000.0 -7.91 524720.0 -8590000.0 -7.13 469800.0 -9442986.4516129 -7.94041516505739 -13.2654 -0.9988 3188902 PK04_102202 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K03 compound treatment 7526800.0 -2210000.0 -1.9 7521600.0 -1600000.0 -1.33 7521520.0 -2391266.4516129 -2.01076730262987 -3.023 -0.9855 3188903 PK04_102203 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K04 compound treatment 3770920.0 -5960000.0 -5.13 3395400.0 -5720000.0 -4.75 2959120.0 -6953666.4516129 -5.84719662874312 -9.0805 -0.9962 3069790 PK04_102204 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K05 compound treatment 8713120.0 -1020000.0 -0.88 8913480.0 -206000.0 -0.17 8604040.0 -1308746.4516129 -1.10049826131299 -1.2414 -0.875 3188904 PK04_102205 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K06 compound treatment 1011480.0 -8720000.0 -7.51 948200.0 -8170000.0 -6.78 1405360.0 -8507426.4516129 -7.15372179745733 -12.3781 -0.9991 3189012 PK04_102206 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K07 mock treatment 1.016908E7 435000.0 0.37 9886200.0 767000.0 0.64 9840360.0 -72426.4516128991 -0.0609019294568754 0.5482 0.7401 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K08 mock treatment 1.048412E7 750000.0 0.65 9392200.0 273000.0 0.23 1.007424E7 161453.548387101 0.135763003646616 0.5817 0.8344 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K09 compound treatment 5759840.0 -3970000.0 -3.42 5141600.0 -3980000.0 -3.3 6022040.0 -3890746.4516129 -3.27164952381177 -5.7689 -0.9998 3069821 PK04_102207 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K10 compound treatment 7399320.0 -2340000.0 -2.01 7724600.0 -1390000.0 -1.16 6516440.0 -3396346.4516129 -2.85591862366483 -3.4771 -0.9452 3189013 PK04_102208 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K11 compound treatment 443080.0 -9290000.0 -8.0 449680.0 -8670000.0 -7.19 440400.0 -9472386.4516129 -7.96513702683797 -13.3677 -0.9988 3069825 PK04_102209 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K12 compound treatment 5018480.0 -4720000.0 -4.06 2883520.0 -6240000.0 -5.17 3265280.0 -6647506.4516129 -5.5897529143641 -8.5571 -0.9916 3189014 PK04_102210 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K13 compound treatment 9821440.0 86900.0 0.07 8880640.0 -238000.0 -0.2 1.065144E7 738653.548387101 0.621118739012337 0.2876 0.4383 3189015 PK04_102211 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K14 compound treatment 4120240.0 -5610000.0 -4.83 3194160.0 -5920000.0 -4.92 4421640.0 -5491146.4516129 -4.61739331951395 -8.2933 -0.9997 3069831 PK04_102212 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K15 mock treatment 9996280.0 262000.0 0.23 9346360.0 227000.0 0.19 1.047848E7 565693.548387101 0.475680194333101 0.5136 0.9186 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K16 mock treatment 9528080.0 -206000.0 -0.18 9549240.0 430000.0 0.36 1.014192E7 229133.548387101 0.192673738521099 0.2147 0.4849 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K17 compound treatment 1193960.0 -8540000.0 -7.35 1020240.0 -8100000.0 -6.72 1425960.0 -8486826.4516129 -7.13639967661787 -12.2429 -0.9993 3189016 PK04_102213 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K18 compound treatment 3830360.0 -5900000.0 -5.08 3353600.0 -5770000.0 -4.78 3458360.0 -6454426.4516129 -5.42739587107856 -8.8286 -0.9987 3069867 PK04_102214 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K19 compound treatment 3993160.0 -5740000.0 -4.94 4225200.0 -4890000.0 -4.06 4832520.0 -5080266.4516129 -4.27189268793552 -7.6631 -0.9964 3189017 PK04_102215 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K20 compound treatment 7542720.0 -2190000.0 -1.89 6664680.0 -2450000.0 -2.04 5250240.0 -4662546.4516129 -3.92064043953468 -4.5282 -0.9427 3069873 PK04_102216 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K21 compound treatment 2870400.0 -6860000.0 -5.91 3139000.0 -5980000.0 -4.96 3272760.0 -6640026.4516129 -5.58346313456414 -9.4985 -0.9974 3189018 PK04_102217 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K22 compound treatment 8933800.0 -801000.0 -0.69 8233440.0 -886000.0 -0.73 7954600.0 -1958186.4516129 -1.64659914276814 -1.7727 -0.9184 3189019 PK04_102218 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K23 mock treatment 9732400.0 -2110.0 0.0 9112040.0 -7050.0 -0.01 8899960.0 -1012826.4516129 -0.851665154574555 -0.4961 -0.5825 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 K24 mock treatment 8930080.0 -804000.0 -0.69 8410520.0 -709000.0 -0.59 1.10896E7 1176813.5483871 0.989558567508256 -0.1678 -0.1249 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L01 compound treatment 6053560.0 -3680000.0 -3.17 5289640.0 -3830000.0 -3.18 6191400.0 -3721386.4516129 -3.12923814588117 -5.4698 -1.0 3069879 PK04_102219 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L02 compound treatment 7168640.0 -2570000.0 -2.21 7870920.0 -1250000.0 -1.04 7825360.0 -2087426.4516129 -1.75527442904442 -2.8862 -0.9605 3189020 PK04_102220 C[C@@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L03 compound treatment 4816320.0 -4920000.0 -4.23 5110800.0 -4010000.0 -3.33 4992000.0 -4920786.4516129 -4.13778920097065 -6.7525 -0.9946 3189021 PK04_102221 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L04 compound treatment 9661040.0 -73500.0 -0.06 9132080.0 13000.0 0.01 1.014916E7 236373.548387101 0.198761707204481 0.0845 0.4044 3069907 PK04_102222 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L05 compound treatment 7077560.0 -2660000.0 -2.29 6990040.0 -2130000.0 -1.77 7095960.0 -2816826.4516129 -2.36861204750554 -3.7074 -0.9923 3189022 PK04_102223 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L06 compound treatment 9668960.0 -65500.0 -0.06 8914200.0 -205000.0 -0.17 9511320.0 -401466.451612899 -0.337584970282823 -0.3256 -0.852 3069909 PK04_102224 C[C@@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L07 mock treatment 9621960.0 -113000.0 -0.1 7764720.0 -1350000.0 -1.12 9712240.0 -200546.451612899 -0.168635430522461 -0.802 -0.7033 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L08 mock treatment 1.036208E7 628000.0 0.54 8829360.0 -290000.0 -0.24 9994200.0 81413.5483871009 0.0684589962684583 0.2126 0.3572 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L09 compound treatment 3415760.0 -6320000.0 -5.44 3279120.0 -5840000.0 -4.84 2843880.0 -7068906.4516129 -5.94409959988578 -9.3686 -0.9966 3189023 PK04_102225 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L10 compound treatment 9761680.0 27200.0 0.02 9063280.0 -55800.0 -0.05 9548600.0 -364186.451612899 -0.306236976841323 -0.19 -0.6118 3069912 PK04_102226 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L11 compound treatment 9946000.0 211000.0 0.18 7777560.0 -1340000.0 -1.11 9201840.0 -710946.451612899 -0.597820405107812 -0.8826 -0.6915 3189024 PK04_102227 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L12 compound treatment 9997240.0 263000.0 0.23 9994480.0 875000.0 0.73 1.006412E7 151333.548387101 0.12725330156432 0.6233 0.8083 3069746 PK04_102228 OCCOc1ccc(cc1)[C@@H](O)CC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L13 compound treatment 5320280.0 -4410000.0 -3.8 5279960.0 -3840000.0 -3.18 5742840.0 -4169946.4516129 -3.50642312276206 -6.0566 -0.9974 3069917 PK04_102229 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L14 compound treatment 1.031972E7 585000.0 0.5 9135440.0 16300.0 0.01 9784920.0 -127866.451612899 -0.107520297385974 0.2365 0.4591 3069920 PK04_102230 O[C@@H](CC=C)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L15 mock treatment 1.038456E7 650000.0 0.56 9627720.0 509000.0 0.42 9837200.0 -75586.4516128991 -0.0635591091584618 0.5299 0.7531 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L16 mock treatment 9746040.0 11500.0 0.01 9066760.0 -52300.0 -0.04 1.022832E7 315533.548387101 0.265325740488525 0.1339 0.4975 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L17 compound treatment 9487040.0 -247000.0 -0.21 7374440.0 -1740000.0 -1.45 9367000.0 -545786.451612899 -0.458940721717302 -1.2235 -0.798 3189025 PK04_102231 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L18 compound treatment 9676760.0 -57700.0 -0.05 9681160.0 562000.0 0.47 9790000.0 -122786.451612899 -0.103248628751778 0.1809 0.3768 3069953 PK04_102232 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L19 compound treatment 5006800.0 -4730000.0 -4.07 5465160.0 -3650000.0 -3.03 542400.0 -9370386.4516129 -7.87936730229309 -8.6484 -0.9228 3189026 PK04_102233 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L20 compound treatment 9530720.0 -204000.0 -0.18 9255040.0 136000.0 0.11 9798240.0 -114546.451612899 -0.0963197804159956 -0.0918 -0.3995 3069956 PK04_102234 CO[C@@H](C=C)[C@@H](O)c1ccc(OC)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L21 compound treatment 9165760.0 -569000.0 -0.49 8773600.0 -345000.0 -0.29 9497720.0 -415066.451612899 -0.349020933555474 -0.6496 -0.9754 3189027 PK04_102235 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L22 compound treatment 9346040.0 -388000.0 -0.33 8816040.0 -303000.0 -0.25 8637600.0 -1275186.4516129 -1.07227834017842 -0.9573 -0.8317 3069961 PK04_102236 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L23 mock treatment 9212680.0 -522000.0 -0.45 8968720.0 -150000.0 -0.12 9517360.0 -395426.451612899 -0.332506057182323 -0.5233 -0.914 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 L24 mock treatment 8586160.0 -1150000.0 -0.99 8319760.0 -799000.0 -0.66 9044200.0 -868586.451612899 -0.730376673512269 -1.3751 -0.9848 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M01 compound treatment 1621880.0 -8110000.0 -6.98 1530920.0 -7590000.0 -6.29 943240.0 -8969546.4516129 -7.54230910242477 -12.02 -0.9973 3069962 PK04_102237 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M02 compound treatment 173080.0 -9560000.0 -8.23 174280.0 -8940000.0 -7.42 163000.0 -9749786.4516129 -8.19839704241394 -13.7685 -0.9989 3188628 PK04_102238 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M03 compound treatment 2105120.0 -7630000.0 -6.57 2461920.0 -6660000.0 -5.52 1444160.0 -8468626.4516129 -7.12109566694418 -11.0908 -0.9947 3189028 PK04_102239 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M04 compound treatment 3215480.0 -6520000.0 -5.61 2456760.0 -6660000.0 -5.53 4296800.0 -5615986.4516129 -4.72236873531966 -9.1566 -0.9971 3189141 PK04_102240 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M05 compound treatment 2555240.0 -7180000.0 -6.18 2257000.0 -6860000.0 -5.69 4474240.0 -5438546.4516129 -4.57316304979767 -9.4942 -0.9926 3069277 PK04_102241 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M06 compound treatment 6380720.0 -3350000.0 -2.89 5274240.0 -3840000.0 -3.19 6265800.0 -3646986.4516129 -3.06667669974255 -5.2785 -0.9992 3189142 PK04_102242 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M07 compound treatment 1773360.0 -7960000.0 -6.85 821560.0 -8300000.0 -6.88 1966840.0 -7945946.4516129 -6.68158469022735 -11.7876 -0.9999 3189143 PK04_102243 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M08 compound treatment 2307080.0 -7430000.0 -6.39 2241680.0 -6880000.0 -5.71 1686200.0 -8226586.4516129 -6.9175691558771 -10.9784 -0.9969 3069284 PK04_102244 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M09 mock treatment 1.015096E7 416000.0 0.36 8813400.0 -306000.0 -0.25 1.015004E7 237253.548387101 0.199501681298594 0.1757 0.3643 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M10 mock treatment 1.011236E7 378000.0 0.33 9052840.0 -66300.0 -0.05 9700560.0 -212226.451612899 -0.178456904862502 0.053 0.1413 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M11 compound treatment 1.028256E7 548000.0 0.47 9268880.0 150000.0 0.12 1.04116E7 498813.548387101 0.419442163180538 0.5862 0.9113 3189144 PK04_102245 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M12 compound treatment 8587440.0 -1150000.0 -0.99 6057520.0 -3060000.0 -2.54 7917440.0 -1995346.4516129 -1.67784623065135 -3.005 -0.9391 3189145 PK04_102246 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M13 mock treatment 1.016084E7 426000.0 0.37 9596680.0 478000.0 0.4 1.115772E7 1244933.5483871 1.0468392894298 1.045 0.8871 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M14 mock treatment 1.002744E7 293000.0 0.25 8986520.0 -133000.0 -0.11 1.095808E7 1045293.5483871 0.878966075624508 0.5895 0.6401 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M15 compound treatment 9354680.0 -380000.0 -0.33 7254120.0 -1860000.0 -1.55 9517840.0 -394946.451612899 -0.33210243494917 -1.2737 -0.7883 3189146 PK04_102247 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M16 compound treatment 8482320.0 -1250000.0 -1.08 6977480.0 -2140000.0 -1.78 9043240.0 -869546.451612899 -0.731183917978573 -2.0701 -0.9397 3189147 PK04_102248 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M17 compound treatment 4803520.0 -4930000.0 -4.24 2903680.0 -6220000.0 -5.16 3507160.0 -6405626.4516129 -5.3863609440414 -8.5369 -0.995 3069327 PK04_102249 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M18 compound treatment 7858240.0 -1880000.0 -1.61 4894000.0 -4230000.0 -3.51 6089360.0 -3823426.4516129 -3.21504150561215 -4.8121 -0.958 3189148 PK04_102250 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M19 compound treatment 8224600.0 -1510000.0 -1.3 6835080.0 -2280000.0 -1.89 6982680.0 -2930106.4516129 -2.46386689452949 -3.2667 -0.9697 3069330 PK04_102251 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M20 compound treatment 5894080.0 -3840000.0 -3.31 2886120.0 -6230000.0 -5.17 3834800.0 -6077986.4516129 -5.11085513472881 -7.8443 -0.9822 3189149 PK04_102252 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M21 compound treatment 3379400.0 -6360000.0 -5.47 2915680.0 -6200000.0 -5.15 3398880.0 -6513906.4516129 -5.47741139280336 -9.2913 -0.9996 3189150 PK04_102253 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M22 compound treatment 8323760.0 -1410000.0 -1.21 7443160.0 -1680000.0 -1.39 8795920.0 -1116866.4516129 -0.939150273610331 -2.0459 -0.9879 3189151 PK04_102254 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M23 compound treatment 3683520.0 -6050000.0 -5.21 3623240.0 -5500000.0 -4.56 3982280.0 -5930506.4516129 -4.98684220359275 -8.5181 -0.9985 3189152 PK04_102255 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 M24 compound treatment 2004320.0 -7730000.0 -6.65 2193720.0 -6930000.0 -5.75 3082080.0 -6830706.4516129 -5.74380206668392 -10.4742 -0.9975 3069375 PK04_102256 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N01 compound treatment 3652840.0 -6080000.0 -5.23 3553720.0 -5570000.0 -4.62 4031600.0 -5881186.4516129 -4.94537001913634 -8.5427 -0.9987 3189153 PK04_102257 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N02 compound treatment 8563680.0 -1170000.0 -1.01 8466840.0 -652000.0 -0.54 9330040.0 -582746.451612899 -0.490019633670034 -1.1771 -0.946 3069379 PK04_102258 CSc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N03 compound treatment 8426040.0 -1310000.0 -1.13 8266600.0 -852000.0 -0.71 9494920.0 -417866.451612899 -0.351375396582196 -1.2613 -0.9171 3189154 PK04_102259 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N04 compound treatment 9448840.0 -286000.0 -0.25 8973160.0 -146000.0 -0.12 9602480.0 -310306.451612899 -0.260930381169969 -0.3625 -0.958 3069716 PK04_102260 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N05 compound treatment 8185240.0 -1550000.0 -1.33 7469600.0 -1650000.0 -1.37 9002120.0 -910666.451612899 -0.765760889285293 -2.002 -0.9726 3069403 PK04_102261 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N06 compound treatment 1.002212E7 288000.0 0.25 8836400.0 -283000.0 -0.23 9640840.0 -271946.451612899 -0.228674237703876 -0.1245 -0.3033 3069417 PK04_102262 C[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N07 compound treatment 4060600.0 -5670000.0 -4.88 3171120.0 -5950000.0 -4.93 4079720.0 -5833066.4516129 -4.90490689026282 -8.5 -1.0 3189155 PK04_102263 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N08 compound treatment 8532040.0 -1200000.0 -1.03 7879680.0 -1240000.0 -1.03 9512160.0 -400626.451612899 -0.336878631374807 -1.3856 -0.9255 3069421 PK04_102264 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N09 mock treatment 9808160.0 73700.0 0.06 9404400.0 285000.0 0.24 9481240.0 -431546.451612899 -0.362878630227038 -0.0363 -0.0828 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N10 mock treatment 9599640.0 -135000.0 -0.12 9131360.0 12300.0 0.01 9964360.0 51573.5483871009 0.0433671474408195 -0.0361 -0.2904 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N11 compound treatment 6050120.0 -3680000.0 -3.17 4644880.0 -4470000.0 -3.71 5665520.0 -4247266.4516129 -3.57143993748569 -6.0356 -0.9978 3189156 PK04_102265 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N12 compound treatment 9772360.0 37900.0 0.03 7981880.0 -1140000.0 -0.94 9868280.0 -44506.4516128991 -0.0374245695618461 -0.5475 -0.5795 3069424 PK04_102266 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N13 mock treatment 9791840.0 57300.0 0.05 9502000.0 383000.0 0.32 1.017168E7 258893.548387101 0.217698316976546 0.3376 0.8695 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N14 mock treatment 9977640.0 243000.0 0.21 9015280.0 -104000.0 -0.09 9462920.0 -449866.451612899 -0.37828354545902 -0.1473 -0.3342 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N15 compound treatment 6226800.0 -3510000.0 -3.02 4214320.0 -4900000.0 -4.07 5591800.0 -4320986.4516129 -3.63342958546067 -6.1899 -0.9928 3189268 PK04_102267 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N16 compound treatment 9220960.0 -514000.0 -0.44 9011360.0 -108000.0 -0.09 9762320.0 -150466.451612899 -0.126524177530231 -0.3798 -0.811 3069404 PK04_102268 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N17 compound treatment 8863760.0 -871000.0 -0.75 6122640.0 -3000000.0 -2.49 6427200.0 -3485586.4516129 -2.93095872384507 -3.56 -0.9092 3069428 PK04_102269 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N18 compound treatment 8677120.0 -1060000.0 -0.91 8355560.0 -764000.0 -0.63 8866840.0 -1045946.4516129 -0.879515088662068 -1.3989 -0.9884 3189269 PK04_102270 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N19 compound treatment 8639240.0 -1100000.0 -0.94 8276160.0 -843000.0 -0.7 8606360.0 -1306426.4516129 -1.09854742051942 -1.5822 -0.9842 3070277 PK04_102271 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N20 compound treatment 9392280.0 -342000.0 -0.29 8701120.0 -418000.0 -0.35 9374000.0 -538786.451612899 -0.453054564150496 -0.6318 -0.984 3069270 PK04_102272 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N21 compound treatment 5944320.0 -3790000.0 -3.26 3062120.0 -6060000.0 -5.02 3771920.0 -6140866.4516129 -5.16372964727177 -7.7656 -0.9819 3070278 PK04_102273 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N22 compound treatment 7952680.0 -1780000.0 -1.53 7850000.0 -1270000.0 -1.05 8335280.0 -1577506.4516129 -1.32649307669222 -2.2591 -0.9888 3070279 PK04_102274 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N23 compound treatment 4032000.0 -5700000.0 -4.91 4322040.0 -4800000.0 -3.98 4406920.0 -5505866.4516129 -4.62977106799729 -7.8041 -0.9963 3070280 PK04_102275 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 N24 compound treatment 7415560.0 -2320000.0 -2.0 7839360.0 -1280000.0 -1.06 8216520.0 -1696266.4516129 -1.42635594421133 -2.5887 -0.9685 3189270 PK04_102276 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O01 compound treatment 7727840.0 -2010000.0 -1.73 8404840.0 -714000.0 -0.59 5537120.0 -4375666.4516129 -3.67940888485394 -3.4635 -0.8432 3189271 PK04_102277 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O02 compound treatment 2986800.0 -6750000.0 -5.81 2866040.0 -6250000.0 -5.19 2159320.0 -7753466.4516129 -6.51973217473325 -10.112 -0.9957 3070281 PK04_102278 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O03 compound treatment 7461960.0 -2270000.0 -1.96 7057560.0 -2060000.0 -1.71 6550320.0 -3362466.4516129 -2.82742962104149 -3.749 -0.9763 3189272 PK04_102279 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O04 compound treatment 382360.0 -9350000.0 -8.05 412040.0 -8710000.0 -7.22 326560.0 -9586226.4516129 -8.06086276646728 -13.4712 -0.9987 3189273 PK04_102280 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O05 compound treatment 1240120.0 -8490000.0 -7.31 1594600.0 -7520000.0 -6.24 956160.0 -8956626.4516129 -7.53144493731575 -12.1729 -0.9968 3070282 PK04_102281 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O06 compound treatment 292240.0 -9440000.0 -8.13 241160.0 -8880000.0 -7.36 394960.0 -9517826.4516129 -8.00334659824306 -13.5646 -0.9991 3189274 PK04_102282 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O07 compound treatment 2378760.0 -7360000.0 -6.33 2956960.0 -6160000.0 -5.11 2524600.0 -7388186.4516129 -6.2125756553043 -10.1932 -0.9957 3070283 PK04_102283 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O08 compound treatment 3787360.0 -5950000.0 -5.12 3255400.0 -5860000.0 -4.86 3558560.0 -6354226.4516129 -5.343139729908 -8.8484 -0.9993 3189275 PK04_102284 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O09 compound treatment 1445960.0 -8290000.0 -7.13 2674800.0 -6440000.0 -5.35 2510160.0 -7402626.4516129 -6.22471795748496 -10.7989 -0.9932 3189276 PK04_102285 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O10 compound treatment 5094240.0 -4640000.0 -3.99 4430240.0 -4690000.0 -3.89 5343320.0 -4569466.4516129 -3.84237136148921 -6.7698 -0.9999 3070284 PK04_102286 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O11 mock treatment 9767600.0 33100.0 0.03 9370640.0 252000.0 0.21 9715760.0 -197026.451612899 -0.165675534146011 0.0413 0.154 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O12 mock treatment 1.026432E7 530000.0 0.46 9985720.0 867000.0 0.72 1.026792E7 355133.548387101 0.298624574723596 0.8507 0.943 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O13 compound treatment 6726920.0 -3010000.0 -2.59 7218360.0 -1900000.0 -1.58 7190720.0 -2722066.4516129 -2.28893029164404 -3.7263 -0.9811 3189277 PK04_102287 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4ccccc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O14 compound treatment 4102320.0 -5630000.0 -4.85 4569280.0 -4550000.0 -3.77 6192040.0 -3720746.4516129 -3.12869998290364 -6.7841 -0.984 3189278 PK04_102288 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O15 compound treatment 530040.0 -9200000.0 -7.92 493480.0 -8630000.0 -7.16 625400.0 -9287386.4516129 -7.80957429114383 -13.2137 -0.999 3070285 PK04_102289 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O16 compound treatment 5520160.0 -4210000.0 -3.63 6201200.0 -2920000.0 -2.42 7289640.0 -2623146.4516129 -2.20575047642856 -4.7651 -0.9751 3189279 PK04_102290 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O17 compound treatment 3960440.0 -5770000.0 -4.97 3794920.0 -5320000.0 -4.42 3961120.0 -5951666.4516129 -5.00463521703755 -8.3085 -0.9984 3070286 PK04_102291 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O18 compound treatment 2624840.0 -7110000.0 -6.12 3198040.0 -5920000.0 -4.91 3661960.0 -6250826.4516129 -5.25619277384976 -9.4033 -0.9957 3189280 PK04_102292 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O19 compound treatment 2261720.0 -7470000.0 -6.43 2592400.0 -6530000.0 -5.41 2840080.0 -7072706.4516129 -5.9472949425649 -10.2728 -0.9976 3189281 PK04_102293 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O20 compound treatment 2636280.0 -7100000.0 -6.11 2227760.0 -6890000.0 -5.72 6556800.0 -3355986.4516129 -2.82198072089393 -8.4569 -0.9578 3070287 PK04_102294 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O21 compound treatment 3005200.0 -6730000.0 -5.79 2611720.0 -6510000.0 -5.4 3202920.0 -6709866.4516129 -5.64219016948781 -9.718 -0.9996 3189282 PK04_102295 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O22 compound treatment 1009240.0 -8730000.0 -7.51 847240.0 -8270000.0 -6.86 1173600.0 -8739186.4516129 -7.34860406569773 -12.54 -0.9993 3070288 PK04_102296 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O23 compound treatment 891000.0 -8840000.0 -7.61 1455600.0 -7660000.0 -6.36 967200.0 -8945586.4516129 -7.52216162595325 -12.4076 -0.9968 3189283 PK04_102297 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 O24 compound treatment 2082440.0 -7650000.0 -6.59 2091240.0 -7030000.0 -5.83 2330560.0 -7582226.4516129 -6.37573994305614 -10.8493 -0.9987 3189284 PK04_102298 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P01 compound treatment 1487400.0 -8250000.0 -7.1 2242760.0 -6880000.0 -5.7 1939480.0 -7973306.4516129 -6.70459115751703 -11.2622 -0.996 3070289 PK04_102299 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P02 compound treatment 7829800.0 -1900000.0 -1.64 7500520.0 -1620000.0 -1.34 8783600.0 -1129186.4516129 -0.949509910927908 -2.2699 -0.9775 3069953 PK04_102300 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P03 compound treatment 4605200.0 -5130000.0 -4.41 4941880.0 -4180000.0 -3.47 5056360.0 -4856426.4516129 -4.08367018654214 -6.9071 -0.9952 3189285 PK04_102301 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P04 compound treatment 7764840.0 -1970000.0 -1.7 8136040.0 -983000.0 -0.82 8461040.0 -1451746.4516129 -1.2207440516063 -2.1543 -0.9607 3070290 PK04_102302 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P05 compound treatment 339200.0 -9400000.0 -8.09 454440.0 -8660000.0 -7.19 473480.0 -9439306.4516129 -7.93732072793655 -13.401 -0.9987 3189394 PK04_102303 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P06 compound treatment 9119080.0 -615000.0 -0.53 8300840.0 -818000.0 -0.68 8271160.0 -1641626.4516129 -1.38041028000416 -1.4947 -0.9187 3069907 PK04_102304 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P07 compound treatment 7344200.0 -2390000.0 -2.06 6764120.0 -2350000.0 -1.95 7075520.0 -2837266.4516129 -2.38579962760061 -3.6931 -0.9963 3189395 PK04_102305 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P08 compound treatment 8164800.0 -1570000.0 -1.35 8283600.0 -835000.0 -0.69 9068080.0 -844706.451612899 -0.710296467412938 -1.5902 -0.9487 3069314 PK04_102306 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P09 compound treatment 3809400.0 -5930000.0 -5.1 4068880.0 -5050000.0 -4.19 3607520.0 -6305266.4516129 -5.30197026212646 -8.424 -0.9951 3070291 PK04_102307 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P10 compound treatment 7611280.0 -2120000.0 -1.83 7312880.0 -1810000.0 -1.5 6750800.0 -3161986.4516129 -2.65885006832818 -3.4552 -0.9713 3189396 PK04_102308 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P11 mock treatment 9730440.0 -4070.0 0.0 8680720.0 -438000.0 -0.36 9121600.0 -791186.451612899 -0.665292588416449 -0.5961 -0.7862 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P12 mock treatment 9744880.0 10400.0 0.01 8673160.0 -446000.0 -0.37 9106520.0 -806266.451612899 -0.677973053574653 -0.5999 -0.7766 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P13 compound treatment 2656520.0 -7080000.0 -6.09 2601520.0 -6520000.0 -5.41 2695400.0 -7217386.4516129 -6.06895341067425 -10.1425 -0.9985 3189397 PK04_102309 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P14 compound treatment 8769760.0 -965000.0 -0.83 8714880.0 -404000.0 -0.34 8865960.0 -1046826.4516129 -0.880255062756181 -1.1812 -0.9407 3070292 PK04_102310 OCCOc1ccc(cc1)[C@H](O)CC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P15 compound treatment 3919200.0 -5820000.0 -5.0 4317680.0 -4800000.0 -3.98 4544400.0 -5368386.4516129 -4.51416693338523 -7.7955 -0.9957 3070293 PK04_102311 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P16 compound treatment 8041600.0 -1690000.0 -1.46 8253040.0 -866000.0 -0.72 8690200.0 -1222586.4516129 -1.02804807046214 -1.8495 -0.9621 3070292 PK04_102312 OCCOc1ccc(cc1)[C@H](O)CC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P17 compound treatment 5949840.0 -3780000.0 -3.26 6644720.0 -2470000.0 -2.05 6741000.0 -3171786.4516129 -2.66709068892171 -4.6055 -0.9833 3189398 PK04_102313 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P18 compound treatment 7922600.0 -1810000.0 -1.56 7909560.0 -1210000.0 -1.0 7836920.0 -2075866.4516129 -1.74555386026266 -2.4874 -0.9767 3070294 PK04_102314 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P19 compound treatment 7892640.0 -1840000.0 -1.59 7430880.0 -1690000.0 -1.4 7581960.0 -2330826.4516129 -1.95994453643876 -2.8554 -0.9902 3189399 PK04_102315 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P20 compound treatment 7916440.0 -1820000.0 -1.56 8040080.0 -1080000.0 -0.9 8079960.0 -1832826.4516129 -1.54118646954318 -2.31 -0.974 3070290 PK04_102316 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P21 compound treatment 3877800.0 -5860000.0 -5.04 3728200.0 -5390000.0 -4.47 3970680.0 -5942106.4516129 -4.9965964075606 -8.3769 -0.9986 3189400 PK04_102317 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P22 compound treatment 8461840.0 -1270000.0 -1.1 7729360.0 -1390000.0 -1.15 8166400.0 -1746386.4516129 -1.46850083238966 -2.1458 -0.9913 3070295 PK04_102318 COc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P23 compound treatment 1749680.0 -7980000.0 -6.87 2939440.0 -6180000.0 -5.13 3081200.0 -6831586.4516129 -5.74454204077803 -10.244 -0.9926 3189401 PK04_102319 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2102 P24 compound treatment 7043720.0 -2690000.0 -2.32 6752280.0 -2370000.0 -1.96 7338800.0 -2573986.4516129 -2.16441283271653 -3.7202 -0.9978 3414053 PK04_102320 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A01 compound treatment 3964960.0 -5730000.0 -4.93 3528760.0 -6450000.0 -5.35 3248600.0 -4961642.5 -4.17214422073686 -8.3474 -0.9949 3070297 PK04_103001 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A02 compound treatment 5955840.0 -3740000.0 -3.22 6087880.0 -3890000.0 -3.23 5300160.0 -2910082.5 -2.44702916105755 -5.1365 -0.9924 3189402 PK04_103002 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A03 compound treatment 6633120.0 -3060000.0 -2.64 7587920.0 -2390000.0 -1.98 6338600.0 -1871642.5 -1.5738260948185 -3.5774 -0.9782 3070298 PK04_103003 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A04 compound treatment 6862680.0 -2840000.0 -2.44 7713160.0 -2270000.0 -1.88 7190960.0 -1019282.5 -0.857093914298183 -2.9895 -0.9349 3189403 PK04_103004 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A05 compound treatment 7751960.0 -1950000.0 -1.67 6343680.0 -3640000.0 -3.02 6333720.0 -1876522.5 -1.57792958752221 -3.6197 -0.954 3070299 PK04_103005 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A06 compound treatment 8265560.0 -1430000.0 -1.23 8059920.0 -1920000.0 -1.59 7141920.0 -1068322.5 -0.898330652451916 -2.1501 -0.9749 3189404 PK04_103006 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccc(OCCO)cc3)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A07 compound treatment 7930000.0 -1770000.0 -1.52 7892480.0 -2090000.0 -1.73 7069880.0 -1140362.5 -0.958907622610868 -2.4321 -0.974 3070300 PK04_103007 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A08 compound treatment 7606880.0 -2090000.0 -1.8 8276040.0 -1700000.0 -1.41 6732880.0 -1477362.5 -1.24228406546993 -2.5725 -0.9879 3189405 PK04_103008 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A09 compound treatment 8298960.0 -1400000.0 -1.2 8870640.0 -1110000.0 -0.92 6861160.0 -1349082.5 -1.13441602365996 -1.8816 -0.9939 3189406 PK04_103009 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A10 compound treatment 8719920.0 -978000.0 -0.84 8811320.0 -1170000.0 -0.97 8698680.0 488437.5 0.410717155219499 -0.8087 -0.5999 3070355 PK04_103010 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A11 compound treatment 8294320.0 -1400000.0 -1.21 8652800.0 -1330000.0 -1.1 7412040.0 -798202.5 -0.671192240745422 -1.7208 -0.9738 3189407 PK04_103011 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1cccc(OCCO)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A12 compound treatment 7837480.0 -1860000.0 -1.6 7759520.0 -2220000.0 -1.84 8208200.0 -2042.5 -0.00171749669002856 -1.9891 -0.8149 3189408 PK04_103012 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccc(CO)o2)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A13 mock treatment 8868480.0 -829000.0 -0.71 8734000.0 -1250000.0 -1.03 7419760.0 -790482.5 -0.664700649828888 -1.3928 -0.9799 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A14 mock treatment 8405160.0 -1290000.0 -1.11 8785400.0 -1200000.0 -0.99 7452880.0 -757362.5 -0.636850715741375 -1.5823 -0.9765 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A15 compound treatment 3883400.0 -5810000.0 -5.0 3451040.0 -6530000.0 -5.42 4459320.0 -3750922.5 -3.15407440798221 -7.8374 -0.9772 3070356 PK04_103013 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A16 compound treatment 8008200.0 -1690000.0 -1.45 8493160.0 -1490000.0 -1.23 7288040.0 -922202.5 -0.775461317643117 -1.9996 -0.9713 3189409 PK04_103014 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A17 compound treatment 7748960.0 -1950000.0 -1.68 8114640.0 -1870000.0 -1.55 6946920.0 -1263322.5 -1.06230218467007 -2.4753 -0.9833 3070357 PK04_103015 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A18 compound treatment 7676400.0 -2020000.0 -1.74 8050360.0 -1930000.0 -1.6 6702960.0 -1507282.5 -1.26744318466976 -2.6606 -0.9918 3189410 PK04_103016 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A19 compound treatment 4922840.0 -4770000.0 -4.11 5627960.0 -4350000.0 -3.61 5228520.0 -2981722.5 -2.50726977935554 -5.9048 -0.9813 3070358 PK04_103017 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccccc1OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A20 compound treatment 7807800.0 -1890000.0 -1.63 8329600.0 -1650000.0 -1.37 6632560.0 -1577682.5 -1.32664111219877 -2.4957 -0.9958 3189411 PK04_103018 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccccc2OCCO)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A21 compound treatment 7537400.0 -2160000.0 -1.86 8227480.0 -1750000.0 -1.45 7056040.0 -1154202.5 -0.970545397000094 -2.4734 -0.9691 3070359 PK04_103019 CCCCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A22 compound treatment 7255400.0 -2440000.0 -2.1 7446920.0 -2530000.0 -2.1 6651720.0 -1558522.5 -1.31052985805877 -3.1837 -0.98 3189412 PK04_103020 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A23 compound treatment 7105160.0 -2590000.0 -2.23 7251080.0 -2730000.0 -2.26 6708480.0 -1501762.5 -1.2628015289885 -3.3246 -0.9719 3070360 PK04_103021 CC(C)C(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 A24 compound treatment 6423640.0 -3270000.0 -2.82 6522600.0 -3460000.0 -2.87 6105800.0 -2104442.5 -1.7695828778974 -4.3047 -0.9799 3189413 PK04_103022 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B01 compound treatment 7356560.0 -2340000.0 -2.01 7310640.0 -2670000.0 -2.21 6833720.0 -1376522.5 -1.15748976132183 -3.1103 -0.9689 3189525 PK04_103023 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B02 compound treatment 7611320.0 -2090000.0 -1.8 7922400.0 -2060000.0 -1.71 6676960.0 -1533282.5 -1.28930605563218 -2.7668 -0.9906 3070361 PK04_103024 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B03 compound treatment 8140520.0 -1560000.0 -1.34 8543280.0 -1440000.0 -1.19 6862240.0 -1348002.5 -1.13350787363536 -2.1166 -0.9975 3189526 PK04_103025 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B04 compound treatment 8381840.0 -1320000.0 -1.13 9444840.0 -536000.0 -0.44 8101920.0 -108322.5 -0.0910861861471819 -0.963 -0.7894 3189527 PK04_103026 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B05 compound treatment 9211280.0 -486000.0 -0.42 8939560.0 -1040000.0 -0.86 8371360.0 161117.5 0.13548042739568 -0.6621 -0.6831 3070362 PK04_103027 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B06 compound treatment 9977080.0 279000.0 0.24 9581040.0 -399000.0 -0.33 8327400.0 117157.5 0.0985153578761426 0.0044 0.0104 3189528 PK04_103028 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B07 compound treatment 9229400.0 -468000.0 -0.4 9399760.0 -581000.0 -0.48 8125080.0 -85162.5 -0.0716114133975802 -0.5522 -0.8734 3070363 PK04_103029 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B08 compound treatment 9842120.0 144000.0 0.12 9976680.0 -3840.0 0.0 8203440.0 -6802.5 -0.00572008383545621 0.0666 0.5353 3189529 PK04_103030 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3c5ccc(CO)cc5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B09 compound treatment 9091040.0 -607000.0 -0.52 9868440.0 -112000.0 -0.09 8035520.0 -174722.5 -0.146920595066593 -0.44 -0.7995 3189530 PK04_103031 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B10 compound treatment 9625920.0 -71800.0 -0.06 1.044972E7 469000.0 0.39 8013320.0 -196922.5 -0.16558812334989 0.0935 0.2186 3070364 PK04_103032 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4ccc(CN5CCCC5)cc4)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B11 compound treatment 8426520.0 -1270000.0 -1.09 8642320.0 -1340000.0 -1.11 7189080.0 -1021162.5 -0.858674768044696 -1.7683 -0.9937 3189531 PK04_103033 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B12 compound treatment 1.006512E7 367000.0 0.32 1.013924E7 159000.0 0.13 8482400.0 272157.5 0.228851703998261 0.3907 0.9485 3189532 PK04_103034 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B13 mock treatment 9136640.0 -561000.0 -0.48 1.00618E7 81300.0 0.07 8583080.0 372837.5 0.31351146740197 -0.0589 -0.1015 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B14 mock treatment 9578520.0 -119000.0 -0.1 9889400.0 -91100.0 -0.08 8853880.0 643637.5 0.541221677272097 0.2096 0.377 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B15 compound treatment 9564960.0 -133000.0 -0.11 9277960.0 -703000.0 -0.58 7872720.0 -337522.5 -0.283815802477437 -0.5663 -0.8603 3070365 PK04_103035 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B16 compound treatment 1.018804E7 490000.0 0.42 1.017068E7 190000.0 0.16 8216440.0 6197.5 0.00521135164575374 0.3377 0.7496 3189533 PK04_103036 CC1C=C(CCCO)C/C(=N/P(=O)(Oc2ccccc2)Oc3ccccc3)/N1Cc4cccc(OC(F)(F)F)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B17 compound treatment 9688440.0 -9270.0 -0.01 9992600.0 12100.0 0.01 8171480.0 -38762.5 -0.0325945975261847 -0.0176 -0.5036 3070366 PK04_103037 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B18 compound treatment 8991240.0 -706000.0 -0.61 9316320.0 -664000.0 -0.55 8090520.0 -119722.5 -0.100672214184551 -0.7273 -0.8797 3189534 PK04_103038 CN1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B19 compound treatment 9651480.0 -46200.0 -0.04 9777240.0 -203000.0 -0.17 7935720.0 -274522.5 -0.230840384376189 -0.2536 -0.8787 3189535 PK04_103039 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B20 compound treatment 8841240.0 -856000.0 -0.74 9662400.0 -318000.0 -0.26 8380320.0 170077.5 0.143014709081191 -0.4954 -0.6224 3070367 PK04_103040 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B21 compound treatment 9693920.0 -3790.0 0.0 9369000.0 -612000.0 -0.51 7499240.0 -711002.5 -0.597867535056075 -0.64 -0.8162 3189536 PK04_103041 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B22 compound treatment 9012320.0 -685000.0 -0.59 9472520.0 -508000.0 -0.42 7546920.0 -663322.5 -0.557774393229607 -0.9059 -0.9904 3189537 PK04_103042 CN1C(=O)C2C(C3C(N(C)C2C=C3c4ccc(CO)cc4)c5cccs5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B23 compound treatment 8889160.0 -809000.0 -0.7 8913880.0 -1070000.0 -0.88 7570200.0 -640042.5 -0.538198714921717 -1.2234 -0.9805 3070368 PK04_103043 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 B24 compound treatment 7679840.0 -2020000.0 -1.74 7909800.0 -2070000.0 -1.72 7370480.0 -839762.5 -0.706139199099198 -2.4021 -0.9447 3189538 PK04_103044 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C01 compound treatment 8228880.0 -1470000.0 -1.26 7813360.0 -2170000.0 -1.8 7315880.0 -894362.5 -0.752051228120279 -2.202 -0.948 3070369 PK04_103045 COCC(=C)C(=O)CC[C@H](OC(=O)C)c1ccc(CO)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C02 compound treatment 7978640.0 -1720000.0 -1.48 8779760.0 -1200000.0 -1.0 7194560.0 -1015682.5 -0.85406674754954 -1.9224 -0.9721 3189539 PK04_103046 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C03 compound treatment 8483040.0 -1210000.0 -1.05 9448480.0 -532000.0 -0.44 7511240.0 -699002.5 -0.587776979227266 -1.1977 -0.9372 3189540 PK04_103047 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C04 compound treatment 8959520.0 -738000.0 -0.64 8634560.0 -1350000.0 -1.12 7027200.0 -1183042.5 -0.994796366175332 -1.5858 -0.976 3070370 PK04_103048 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C05 compound treatment 8992760.0 -705000.0 -0.61 9524200.0 -456000.0 -0.38 8286440.0 76197.5 0.0640729273138073 -0.5318 -0.7407 3189541 PK04_103049 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C06 compound treatment 9913400.0 216000.0 0.19 1.045192E7 471000.0 0.39 8129800.0 -80442.5 -0.0676424614382486 0.2939 0.6708 3189542 PK04_103050 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C07 compound treatment 9652400.0 -45300.0 -0.04 9944960.0 -35600.0 -0.03 8447720.0 237477.5 0.199689997653003 0.0757 0.3684 3070371 PK04_103051 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C08 compound treatment 9794160.0 96400.0 0.08 9635440.0 -345000.0 -0.29 8139400.0 -70842.5 -0.0595700167752012 -0.1517 -0.4992 3189543 PK04_103052 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccc(CO)o3)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C09 compound treatment 9868880.0 171000.0 0.15 1.041692E7 436000.0 0.36 8058360.0 -151882.5 -0.127714903805759 0.2203 0.5358 3070372 PK04_103053 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C10 compound treatment 9758480.0 60800.0 0.05 1.019984E7 219000.0 0.18 7944080.0 -266162.5 -0.223810630482119 0.006 0.0205 3189544 PK04_103054 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C11 mock treatment 9327920.0 -370000.0 -0.32 1.029868E7 318000.0 0.26 8750520.0 540277.5 0.454308356399954 0.2309 0.3759 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C12 mock treatment 9882240.0 185000.0 0.16 1.042612E7 446000.0 0.37 8794280.0 584037.5 0.491105249989012 0.5887 0.9272 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C13 compound treatment 1.005312E7 355000.0 0.31 1.024552E7 265000.0 0.22 8184960.0 -25282.5 -0.0212595398118223 0.2912 0.772 3189545 PK04_103055 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C14 compound treatment 9385240.0 -312000.0 -0.27 9707760.0 -273000.0 -0.23 8331880.0 121637.5 0.102282498718898 -0.2268 -0.6197 3189546 PK04_103056 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C15 mock treatment 9802680.0 105000.0 0.09 1.01346E7 154000.0 0.13 8254360.0 44117.5 0.0370975080647908 0.1474 0.9162 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C16 mock treatment 9364640.0 -333000.0 -0.29 1.032708E7 347000.0 0.29 8725880.0 515637.5 0.4335890817648 0.2508 0.4223 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C17 compound treatment 1.035288E7 655000.0 0.56 1.017676E7 196000.0 0.16 8481640.0 271397.5 0.228212635462437 0.5513 0.8755 3070427 PK04_103057 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C18 compound treatment 9192520.0 -505000.0 -0.43 1.055932E7 579000.0 0.48 8348480.0 138237.5 0.116241100948751 0.0933 0.1418 3189660 PK04_103058 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3ccccc3OCCO)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C19 compound treatment 9523680.0 -174000.0 -0.15 9579680.0 -401000.0 -0.33 7388640.0 -821602.5 -0.6908688246116 -0.6773 -0.867 3070428 PK04_103059 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C20 compound treatment 9349920.0 -348000.0 -0.3 9019360.0 -961000.0 -0.8 7767880.0 -442362.5 -0.371973625235134 -0.8479 -0.9124 3189661 PK04_103060 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C21 compound treatment 9339200.0 -359000.0 -0.31 1.024264E7 262000.0 0.22 7512120.0 -698122.5 -0.587037005133153 -0.3915 -0.561 3189662 PK04_103061 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C22 compound treatment 9404480.0 -293000.0 -0.25 9655920.0 -325000.0 -0.27 7791320.0 -418922.5 -0.35226340618286 -0.5045 -0.989 3070429 PK04_103062 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C23 compound treatment 8459680.0 -1240000.0 -1.07 9447280.0 -533000.0 -0.44 8181400.0 -28842.5 -0.0242530713743691 -0.8846 -0.7666 3189663 PK04_103063 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 C24 compound treatment 8169440.0 -1530000.0 -1.32 8236400.0 -1740000.0 -1.45 7421920.0 -788322.5 -0.662884349779702 -1.9774 -0.9578 3189664 PK04_103064 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)c2ccncc2)c3cccc(OCCO)c3)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D01 compound treatment 7923320.0 -1770000.0 -1.53 8187200.0 -1790000.0 -1.49 7272360.0 -937882.5 -0.788646310592761 -2.1959 -0.966 3070430 PK04_103065 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D02 compound treatment 2096400.0 -7600000.0 -6.54 5008800.0 -4970000.0 -4.12 4087600.0 -4122642.5 -3.46664619237262 -8.1597 -0.9628 3189665 PK04_103066 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5ccc(CN6CCCC6)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D03 compound treatment 8920480.0 -777000.0 -0.67 9626880.0 -354000.0 -0.29 8329320.0 119077.5 0.100129846808752 -0.4978 -0.6752 3070431 PK04_103067 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D04 compound treatment 9247280.0 -450000.0 -0.39 8932920.0 -1050000.0 -0.87 7431120.0 -779122.5 -0.655148256977615 -1.1038 -0.9554 3189666 PK04_103068 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D05 compound treatment 8985600.0 -712000.0 -0.61 8780080.0 -1200000.0 -1.0 7494640.0 -715602.5 -0.601735581457119 -1.2762 -0.9704 3189667 PK04_103069 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D06 compound treatment 9558840.0 -139000.0 -0.12 9924000.0 -56500.0 -0.05 8421880.0 211637.5 0.177961667434967 0.0067 0.0304 3189668 PK04_103070 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D07 compound treatment 8236440.0 -1460000.0 -1.26 8622480.0 -1360000.0 -1.13 7043960.0 -1166282.5 -0.980703223201095 -1.9427 -0.995 3070432 PK04_103071 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D08 compound treatment 9841160.0 143000.0 0.12 9696280.0 -284000.0 -0.24 7882240.0 -328002.5 -0.275810628186582 -0.2241 -0.5847 3189669 PK04_103072 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D09 compound treatment 8892240.0 -805000.0 -0.69 9740680.0 -240000.0 -0.2 7720680.0 -489562.5 -0.41166314482845 -0.7528 -0.9065 3070433 PK04_103073 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D10 compound treatment 1.0404E7 706000.0 0.61 1.108332E7 1100000.0 0.91 8564960.0 354717.5 0.298274728100468 1.0513 0.9237 3189670 PK04_103074 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D11 mock treatment 1.025584E7 558000.0 0.48 1.045252E7 472000.0 0.39 8402920.0 192677.5 0.162018589225448 0.5969 0.9319 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D12 mock treatment 1.028012E7 582000.0 0.5 1.055588E7 575000.0 0.48 8785360.0 575117.5 0.483604603489597 0.8442 0.9998 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D13 compound treatment 9979280.0 282000.0 0.24 9770240.0 -210000.0 -0.17 7676080.0 -534162.5 -0.449166377325524 -0.2201 -0.4081 3189671 PK04_103075 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D14 compound treatment 1.017492E7 477000.0 0.41 1.043076E7 450000.0 0.37 8952640.0 742397.5 0.624266951743197 0.8132 0.9734 3070434 PK04_103076 NC(=O)N1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D15 mock treatment 9936160.0 238000.0 0.21 1.057756E7 597000.0 0.5 8578680.0 368437.5 0.309811596931407 0.5833 0.942 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D16 mock treatment 1.02014E7 504000.0 0.43 1.073508E7 755000.0 0.63 8288200.0 77957.5 0.0655528755020326 0.6495 0.8499 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D17 compound treatment 9804400.0 107000.0 0.09 9461880.0 -519000.0 -0.43 7694720.0 -515522.5 -0.433492380604773 -0.4457 -0.7216 3189672 PK04_103077 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D18 compound treatment 9760200.0 62500.0 0.05 1.001136E7 30800.0 0.03 8240040.0 29797.5 0.0250561114424118 0.0603 0.9331 3189673 PK04_103078 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D19 compound treatment 1.01266E7 429000.0 0.37 9917280.0 -63200.0 -0.05 8005800.0 -204442.5 -0.171911538335943 0.0836 0.2036 3070435 PK04_103079 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D20 compound treatment 9901160.0 203000.0 0.18 9689800.0 -291000.0 -0.24 7673640.0 -536602.5 -0.451218123677382 -0.2987 -0.5523 3189674 PK04_103080 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)CC2)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D21 compound treatment 1.051868E7 821000.0 0.71 1.019268E7 212000.0 0.18 7644280.0 -565962.5 -0.475906350271868 0.2348 0.2699 3189675 PK04_103081 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D22 compound treatment 1.053744E7 840000.0 0.72 1.000904E7 28500.0 0.02 7627040.0 -583202.5 -0.490403115479257 0.1478 0.1691 3070436 PK04_103082 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D23 compound treatment 8864720.0 -833000.0 -0.72 9533600.0 -447000.0 -0.37 8082640.0 -127602.5 -0.107298345845469 -0.6899 -0.8473 3189676 PK04_103083 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 D24 compound treatment 8685200.0 -1010000.0 -0.87 8302360.0 -1680000.0 -1.39 7415520.0 -794722.5 -0.668265979555067 -1.6927 -0.9546 3070437 PK04_103084 CN1CCC(=CC1C2CC2)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E01 mock treatment 8335520.0 -1360000.0 -1.17 8854400.0 -1130000.0 -0.93 8159680.0 -50562.5 -0.0425169774245137 -1.2408 -0.8274 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E02 mock treatment 9047960.0 -650000.0 -0.56 9540960.0 -440000.0 -0.36 7921080.0 -289162.5 -0.243150862487336 -0.6738 -0.9483 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E03 compound treatment 9064000.0 -634000.0 -0.55 9960640.0 -19900.0 -0.02 7837960.0 -372282.5 -0.313044779194888 -0.5051 -0.803 3189677 PK04_103085 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E04 compound treatment 9370480.0 -327000.0 -0.28 9311000.0 -670000.0 -0.56 7638040.0 -572202.5 -0.481153439302849 -0.7611 -0.9671 3070438 PK04_103086 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E05 compound treatment 9271880.0 -426000.0 -0.37 9652720.0 -328000.0 -0.27 8192320.0 -17922.5 -0.0150706655701527 -0.3773 -0.8263 3189678 PK04_103087 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E06 compound treatment 9730200.0 32500.0 0.03 9636840.0 -344000.0 -0.29 8387760.0 177517.5 0.149270853695053 -0.0623 -0.1928 3189679 PK04_103088 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E07 compound treatment 1.00176E7 320000.0 0.28 1.031192E7 331000.0 0.27 8530200.0 319957.5 0.269045751383018 0.473 0.9999 3189680 PK04_103089 COCC(=C)C(=O)CC[C@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E08 compound treatment 1.061524E7 918000.0 0.79 1.035608E7 376000.0 0.31 8394160.0 183917.5 0.154652483470418 0.7251 0.8403 3070490 PK04_103090 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E09 mock treatment 9700680.0 2970.0 0.0 1.05342E7 554000.0 0.46 8847800.0 637557.5 0.536109128985501 0.5762 0.8162 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E10 mock treatment 1.043692E7 739000.0 0.64 1.105148E7 1070000.0 0.89 8408240.0 197997.5 0.166492068976221 0.9764 0.8833 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E11 compound treatment 5393840.0 -4300000.0 -3.7 6397200.0 -3580000.0 -2.97 5114880.0 -3095362.5 -2.60282734305436 -5.3575 -0.9892 3187704 PK04_103091 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E12 compound treatment 9460200.0 -238000.0 -0.2 1.018152E7 201000.0 0.17 7800840.0 -409402.5 -0.344258231892004 -0.2205 -0.5084 3070491 PK04_103092 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E13 compound treatment 6956920.0 -2740000.0 -2.36 8298880.0 -1680000.0 -1.4 6150680.0 -2059562.5 -1.73184419909765 -3.1672 -0.977 3187705 PK04_103093 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E14 compound treatment 9441040.0 -257000.0 -0.22 9860240.0 -120000.0 -0.1 8001840.0 -208402.5 -0.17524142175945 -0.2863 -0.9573 3187706 PK04_103094 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccccc1OCCO)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E15 compound treatment 9934520.0 237000.0 0.2 1.0216E7 235000.0 0.2 8260760.0 50517.5 0.0424791378401557 0.255 0.8931 3070492 PK04_103095 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E16 compound treatment 1.021328E7 516000.0 0.44 9770880.0 -210000.0 -0.17 8314080.0 103837.5 0.0873148409061645 0.2062 0.4256 3187707 PK04_103096 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E17 mock treatment 1.046024E7 763000.0 0.66 1.105028E7 1070000.0 0.89 8715720.0 505477.5 0.425045744496408 1.1367 0.961 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E18 mock treatment 9907640.0 210000.0 0.18 1.036644E7 386000.0 0.32 8609120.0 398877.5 0.335407973550486 0.4828 0.9702 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E19 compound treatment 8690520.0 -1010000.0 -0.87 9907200.0 -73300.0 -0.06 7424880.0 -785362.5 -0.660395346008596 -0.9169 -0.8401 3070493 PK04_103097 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E20 compound treatment 9675520.0 -22200.0 -0.02 1.015184E7 171000.0 0.14 7434000.0 -776242.5 -0.652726523578701 -0.3058 -0.4576 3187708 PK04_103098 CC(C)C(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E21 compound treatment 9114680.0 -583000.0 -0.5 9522080.0 -458000.0 -0.38 7191120.0 -1019122.5 -0.856959373553799 -1.004 -0.9442 3187709 PK04_103099 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E22 compound treatment 8911920.0 -786000.0 -0.68 9913440.0 -67100.0 -0.06 7882960.0 -327282.5 -0.275205194836853 -0.5815 -0.7941 3070494 PK04_103100 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E23 compound treatment 9367560.0 -330000.0 -0.28 1.000324E7 22700.0 0.02 7997440.0 -212802.5 -0.178941292230014 -0.2565 -0.7626 3187710 PK04_103101 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 E24 compound treatment 8746360.0 -951000.0 -0.82 8816120.0 -1160000.0 -0.97 7745520.0 -464722.5 -0.390775694262815 -1.256 -0.9478 3187711 PK04_103102 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F01 mock treatment 8054520.0 -1640000.0 -1.41 8545840.0 -1430000.0 -1.19 7701000.0 -509242.5 -0.428211656387697 -1.7509 -0.9228 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F02 mock treatment 9284840.0 -413000.0 -0.36 9134960.0 -846000.0 -0.7 7679320.0 -530922.5 -0.446441927251745 -0.8679 -0.9598 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F03 compound treatment 9781600.0 83900.0 0.07 9684080.0 -296000.0 -0.25 7898040.0 -312202.5 -0.26252472967865 -0.2519 -0.6865 3070495 PK04_103103 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F04 compound treatment 8697600.0 -1000000.0 -0.86 9757840.0 -223000.0 -0.18 7765200.0 -445042.5 -0.374227182703568 -0.8197 -0.8569 3187712 PK04_103104 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F05 compound treatment 5266360.0 -4430000.0 -3.81 6222840.0 -3760000.0 -3.12 5406000.0 -2804242.5 -2.35803045864745 -5.3631 -0.9821 3070496 PK04_103105 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F06 compound treatment 1.004884E7 351000.0 0.3 9993240.0 12700.0 0.01 8488680.0 278437.5 0.234132428215338 0.3157 0.8256 3187713 PK04_103106 CN1C(C2CC2)C3C4C(C1C=C3c5ccc(CO)cc5)C(=O)N(C(=O)N)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F07 compound treatment 9330640.0 -367000.0 -0.32 9932640.0 -47900.0 -0.04 7682240.0 -528002.5 -0.443986558666735 -0.4617 -0.845 3070497 PK04_103107 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F08 compound treatment 1.010188E7 404000.0 0.35 1.016956E7 189000.0 0.16 8167960.0 -42282.5 -0.0355544939026354 0.2708 0.7068 3187714 PK04_103108 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)CC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F09 mock treatment 1.020496E7 507000.0 0.44 1.062828E7 648000.0 0.54 8764520.0 554277.5 0.466080671533565 0.8314 0.9961 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F10 mock treatment 1.059328E7 896000.0 0.77 1.11024E7 1120000.0 0.93 9060720.0 850477.5 0.715149224574672 1.3952 0.9936 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F11 compound treatment 1.0006E7 308000.0 0.27 1.011732E7 137000.0 0.11 8430400.0 220157.5 0.185125962073421 0.3256 0.9496 3187715 PK04_103109 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F12 compound treatment 1.0316E7 618000.0 0.53 1.102016E7 1040000.0 0.86 8766640.0 556397.5 0.467863336396655 1.0753 0.9633 3070498 PK04_103110 CC1C=C(CCCO)CCN1Cc2cccc(OC(F)(F)F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F13 compound treatment 9220320.0 -477000.0 -0.41 9537560.0 -443000.0 -0.37 7515360.0 -694882.5 -0.584312555059375 -0.7867 -0.9794 3187716 PK04_103111 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F14 compound treatment 1.005372E7 356000.0 0.31 1.044268E7 462000.0 0.38 8634160.0 423917.5 0.356463600046601 0.6041 0.9958 3070499 PK04_103112 CN1CCC(=CC1c2cccs2)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F15 compound treatment 9848120.0 150000.0 0.13 1.022076E7 240000.0 0.2 8431120.0 220877.5 0.18573139542315 0.297 0.9848 3187717 PK04_103113 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F16 compound treatment 1.030612E7 608000.0 0.52 1.044324E7 463000.0 0.38 8385320.0 175077.5 0.147219107343195 0.6089 0.9147 3187718 PK04_103114 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F17 mock treatment 1.01196E7 422000.0 0.36 1.036772E7 387000.0 0.32 8827200.0 616957.5 0.518787008146045 0.6946 0.9783 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F18 mock treatment 9785720.0 88000.0 0.08 9907440.0 -73100.0 -0.06 8226640.0 16397.5 0.0137883241002415 0.0167 0.1703 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F19 compound treatment 9771160.0 73400.0 0.06 9895720.0 -84800.0 -0.07 7221400.0 -988842.5 -0.831497537679104 -0.4842 -0.5786 3070500 PK04_103115 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1cccc(OCCO)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F20 compound treatment 7799120.0 -1900000.0 -1.63 8398080.0 -1580000.0 -1.31 6383960.0 -1826282.5 -1.5356837937856 -2.5879 -0.996 3187719 PK04_103116 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)CC1)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F21 compound treatment 8948120.0 -750000.0 -0.65 9453440.0 -527000.0 -0.44 7201960.0 -1008282.5 -0.847844238121775 -1.1144 -0.9677 3070501 PK04_103117 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F22 compound treatment 1.004152E7 344000.0 0.3 9569800.0 -411000.0 -0.34 7297880.0 -912362.5 -0.767187061863493 -0.4688 -0.5267 3187720 PK04_103118 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)CC2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F23 compound treatment 9582720.0 -115000.0 -0.1 9587920.0 -393000.0 -0.33 7675080.0 -535162.5 -0.450007256977924 -0.505 -0.895 3187721 PK04_103119 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 F24 compound treatment 8226680.0 -1470000.0 -1.27 9092720.0 -888000.0 -0.74 7123720.0 -1086522.5 -0.91363466212561 -1.6836 -0.9753 3070502 PK04_103120 CN1C(C2C3C(C1C=C2c4ccc(CO)cc4)C(=O)N(C(=O)N)C3=O)c5cccs5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G01 compound treatment 3761640.0 -5940000.0 -5.11 4856480.0 -5120000.0 -4.25 3771400.0 -4438842.5 -3.73253233846174 -7.5587 -0.9916 3187722 PK04_103121 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G02 compound treatment 8240000.0 -1460000.0 -1.25 8522200.0 -1460000.0 -1.21 6810840.0 -1399402.5 -1.17672908776876 -2.1022 -0.9997 3187723 PK04_103122 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G03 mock treatment 9517080.0 -181000.0 -0.16 9861160.0 -119000.0 -0.1 7665000.0 -545242.5 -0.458483323874124 -0.4116 -0.833 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G04 mock treatment 9498680.0 -199000.0 -0.17 9922680.0 -57800.0 -0.05 8688880.0 478637.5 0.402476534625971 0.1058 0.2404 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G05 compound treatment 8810040.0 -888000.0 -0.76 8434360.0 -1550000.0 -1.28 6373320.0 -1836922.5 -1.54463075328714 -2.0734 -0.9652 3070503 PK04_103123 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G06 compound treatment 8698160.0 -1000000.0 -0.86 9353240.0 -627000.0 -0.52 7683640.0 -526602.5 -0.442809327153374 -1.0528 -0.9583 3187724 PK04_103124 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G07 compound treatment 6532480.0 -3170000.0 -2.72 5556520.0 -4420000.0 -3.67 4660360.0 -3549882.5 -2.98502396266356 -5.4151 -0.992 3070504 PK04_103125 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G08 compound treatment 9195720.0 -502000.0 -0.43 9026880.0 -954000.0 -0.79 7756320.0 -453922.5 -0.381694194016886 -0.9266 -0.9465 3187725 PK04_103126 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G09 compound treatment 9637840.0 -59900.0 -0.05 1.073456E7 754000.0 0.63 8144000.0 -66242.5 -0.0557019703741577 0.2992 0.4749 3187726 PK04_103127 CCCCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G10 compound treatment 9956520.0 259000.0 0.22 1.126024E7 1280000.0 1.06 8631760.0 421517.5 0.35444548888084 0.9462 0.8291 3070543 PK04_103128 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G11 compound treatment 1.00534E7 356000.0 0.31 1.084532E7 865000.0 0.72 8572200.0 361957.5 0.30436269678385 0.7667 0.9157 3187727 PK04_103129 CC(C)C(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G12 compound treatment 1.0185E7 487000.0 0.42 1.021084E7 230000.0 0.19 8634680.0 424437.5 0.35690085746585 0.5585 0.9582 3187844 PK04_103130 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G13 compound treatment 1.041672E7 719000.0 0.62 1.04026E7 422000.0 0.35 8485800.0 275557.5 0.231710694816424 0.6932 0.927 3070544 PK04_103131 COCC(=C)C(=O)CC[C@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G14 compound treatment 9416800.0 -281000.0 -0.24 9937760.0 -42800.0 -0.04 7227800.0 -982442.5 -0.826115907903739 -0.637 -0.7394 3187845 PK04_103132 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G15 compound treatment 1.025872E7 561000.0 0.48 1.005824E7 77700.0 0.06 8312000.0 101757.5 0.0855658112291709 0.3654 0.7388 3070545 PK04_103133 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G16 compound treatment 1.07416E7 1040000.0 0.9 1.008696E7 106000.0 0.09 8154480.0 -55762.5 -0.0468895516169977 0.5426 0.6003 3187846 PK04_103134 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G17 compound treatment 1.026012E7 562000.0 0.48 9911040.0 -69500.0 -0.06 8653200.0 442957.5 0.372473948628312 0.4612 0.7518 3070546 PK04_103135 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G18 compound treatment 1.044008E7 742000.0 0.64 1.060872E7 628000.0 0.52 7615320.0 -594922.5 -0.500258225005394 0.3809 0.395 3187847 PK04_103136 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G19 mock treatment 9815480.0 118000.0 0.1 1.078336E7 803000.0 0.67 8344080.0 133837.5 0.112541230478187 0.508 0.7438 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G20 mock treatment 1.035348E7 656000.0 0.56 1.037748E7 397000.0 0.33 8542240.0 331997.5 0.279169942397923 0.6772 0.953 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G21 compound treatment 1.019612E7 498000.0 0.43 1.067292E7 692000.0 0.57 8302640.0 92397.5 0.0776951776826997 0.6241 0.8656 3070547 PK04_103137 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G22 compound treatment 9238920.0 -459000.0 -0.39 9754600.0 -226000.0 -0.19 7862520.0 -347722.5 -0.292392774931925 -0.505 -0.9603 3187848 PK04_103138 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G23 compound treatment 9842800.0 145000.0 0.12 1.0063E7 82500.0 0.07 7736400.0 -473842.5 -0.39844451669271 -0.1184 -0.2799 3070548 PK04_103139 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 G24 compound treatment 8968360.0 -729000.0 -0.63 9246600.0 -734000.0 -0.61 7936680.0 -273562.5 -0.230033139909884 -0.8467 -0.9364 3187849 PK04_103140 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(CO)o1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H01 compound treatment 1956160.0 -7740000.0 -6.66 2120200.0 -7860000.0 -6.52 1901600.0 -6308642.5 -5.30480911252069 -10.6742 -0.9951 3070549 PK04_103141 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccccc1OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H02 compound treatment 8398960.0 -1300000.0 -1.12 9383160.0 -597000.0 -0.5 7799600.0 -410642.5 -0.345300922660981 -1.1308 -0.89 3187850 PK04_103142 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)CC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H03 mock treatment 9224000.0 -474000.0 -0.41 9729320.0 -251000.0 -0.21 7297360.0 -912882.5 -0.767624319282742 -0.7989 -0.8938 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H04 mock treatment 9735880.0 38200.0 0.03 1.043564E7 455000.0 0.38 8358800.0 148557.5 0.124918978961527 0.3091 0.7745 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H05 compound treatment 1.00318E7 334000.0 0.29 9889520.0 -91000.0 -0.08 8342040.0 131797.5 0.11082583598729 0.1864 0.5876 3187851 PK04_103143 CCCCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H06 compound treatment 1.009268E7 395000.0 0.34 1.095172E7 971000.0 0.81 8264920.0 54677.5 0.0459771971941428 0.688 0.7856 3187852 PK04_103144 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H07 compound treatment 9584800.0 -113000.0 -0.1 1.045192E7 471000.0 0.39 8553520.0 343277.5 0.288655064877004 0.3363 0.6785 3070550 PK04_103145 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H08 compound treatment 1.018808E7 490000.0 0.42 1.090564E7 925000.0 0.77 8228920.0 18677.5 0.0157055297077153 0.6958 0.7943 3187853 PK04_103146 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C(=O)N)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H09 compound treatment 1.015412E7 456000.0 0.39 1.004792E7 67400.0 0.06 8081200.0 -129042.5 -0.108509212544926 0.1964 0.4775 3070551 PK04_103147 COCC(=C)C(=O)CC[C@@H](OC(=O)C)c1ccc(CO)o1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H10 compound treatment 1.013824E7 441000.0 0.38 1.052488E7 544000.0 0.45 7638920.0 -571322.5 -0.480413465208736 0.2023 0.2659 3070552 PK04_103148 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)CC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H11 compound treatment 9490640.0 -207000.0 -0.18 1.020264E7 222000.0 0.18 8203800.0 -6442.5 -0.00541736716059193 4.0E-4 0.0014 3187854 PK04_103149 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H12 compound treatment 1.048656E7 789000.0 0.68 1.064916E7 669000.0 0.55 9434920.0 1224677.5 1.02980639050304 1.3068 0.9662 3070553 PK04_103150 CN1CCC(=CC1c2cccs2)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H13 compound treatment 1.013812E7 440000.0 0.38 1.039596E7 415000.0 0.34 8222880.0 12637.5 0.0106266166072147 0.4239 0.8274 3187855 PK04_103151 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H14 compound treatment 9972720.0 275000.0 0.24 1.084796E7 867000.0 0.72 7971920.0 -238322.5 -0.200400540959281 0.4364 0.5569 3187856 PK04_103152 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H15 compound treatment 1.030028E7 603000.0 0.52 1.051012E7 530000.0 0.44 8690800.0 480557.5 0.404091023558581 0.7864 0.9945 3070554 PK04_103153 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(OCCO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H16 compound treatment 1.039964E7 702000.0 0.6 1.073924E7 759000.0 0.63 8181640.0 -28602.5 -0.0240512602577929 0.6983 0.8001 3187857 PK04_103154 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H17 compound treatment 1.000416E7 306000.0 0.26 1.016752E7 187000.0 0.16 8261040.0 50797.5 0.0427145841428279 0.2665 0.8626 3187858 PK04_103155 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H18 compound treatment 1.042216E7 724000.0 0.62 9971600.0 -8920.0 -0.01 7947840.0 -262402.5 -0.220648922989092 0.2283 0.3452 3070555 PK04_103156 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)CC2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H19 mock treatment 1.048776E7 790000.0 0.68 9933880.0 -46600.0 -0.04 8280480.0 70237.5 0.0590612845854987 0.4043 0.5915 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H20 mock treatment 1.039984E7 702000.0 0.6 1.058656E7 606000.0 0.5 7961640.0 -248602.5 -0.209044783785961 0.5185 0.6374 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H21 compound treatment 9988240.0 291000.0 0.25 1.0403E7 422000.0 0.35 8281640.0 71397.5 0.0600367049822836 0.3814 0.8773 3187859 PK04_103157 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H22 compound treatment 9792440.0 94700.0 0.08 9733560.0 -247000.0 -0.2 7691760.0 -518482.5 -0.43598138437588 -0.3229 -0.661 3070556 PK04_103158 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H23 compound treatment 1.002956E7 332000.0 0.29 9292480.0 -688000.0 -0.57 7970400.0 -239842.5 -0.201678678030931 -0.2811 -0.4199 3187860 PK04_103159 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3cccc(OCCO)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 H24 compound treatment 8744560.0 -953000.0 -0.82 8341680.0 -1640000.0 -1.36 7403280.0 -806962.5 -0.678558346500452 -1.6503 -0.9557 3070597 PK04_103160 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I01 compound treatment 8265560.0 -1430000.0 -1.23 8694280.0 -1290000.0 -1.07 7876160.0 -334082.5 -0.280923176473179 -1.4899 -0.9006 3187861 PK04_103161 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I02 compound treatment 8375440.0 -1320000.0 -1.14 8608240.0 -1370000.0 -1.14 7460360.0 -749882.5 -0.630560935941417 -1.6783 -0.9708 3187862 PK04_103162 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I03 compound treatment 8989400.0 -708000.0 -0.61 9573760.0 -407000.0 -0.34 7954200.0 -256042.5 -0.215300928399823 -0.6711 -0.9202 3070598 PK04_103163 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I04 compound treatment 9772200.0 74500.0 0.06 9932520.0 -48000.0 -0.04 7943320.0 -266922.5 -0.224449699017943 -0.1156 -0.488 3187863 PK04_103164 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I05 mock treatment 9483240.0 -214000.0 -0.18 9846200.0 -134000.0 -0.11 8282560.0 72317.5 0.0608103142624923 -0.1358 -0.6062 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I06 mock treatment 1.018148E7 484000.0 0.42 9932520.0 -48000.0 -0.04 8123760.0 -86482.5 -0.0727213745387492 0.1754 0.4132 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I07 compound treatment 9078840.0 -619000.0 -0.53 9766880.0 -214000.0 -0.18 8573880.0 363637.5 0.305775374599883 -0.2333 -0.365 3070599 PK04_103165 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I08 compound treatment 1.040392E7 706000.0 0.61 1.052156E7 541000.0 0.45 8445680.0 235437.5 0.197974603162105 0.7243 0.9274 3187864 PK04_103166 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I09 compound treatment 1.022836E7 531000.0 0.46 1.043552E7 455000.0 0.38 8011240.0 -199002.5 -0.167337153026883 0.385 0.6253 3187865 PK04_103167 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I10 compound treatment 1.068752E7 990000.0 0.85 1.028436E7 304000.0 0.25 8339480.0 129237.5 0.108673184077144 0.7001 0.7822 3070600 PK04_103168 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I11 compound treatment 1.086008E7 1160000.0 1.0 1.069304E7 713000.0 0.59 8529080.0 318837.5 0.268103966172329 1.0736 0.9003 3187866 PK04_103169 COCC(=C=CC[C@H](O)c1ccccc1OCCO)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I12 compound treatment 1.00372E7 339000.0 0.29 1.072412E7 744000.0 0.62 8834920.0 624677.5 0.525278599062579 0.8281 0.9615 3187978 PK04_103170 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I13 compound treatment 1.02724E7 575000.0 0.49 1.090468E7 924000.0 0.77 8337680.0 127437.5 0.107159600702823 0.7901 0.86 3070601 PK04_103171 CCCCC(=C=CC[C@H](O)c1ccc(CO)o1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I14 compound treatment 9693800.0 -3910.0 0.0 1.01174E7 137000.0 0.11 7921000.0 -289242.5 -0.243218132859528 -0.0768 -0.2861 3187979 PK04_103172 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I15 compound treatment 1.019892E7 501000.0 0.43 1.053204E7 552000.0 0.46 8334240.0 123997.5 0.104266974698564 0.5734 0.8996 3070602 PK04_103173 CC(C)C(=C=CC[C@H](O)c1ccc(CO)o1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I16 compound treatment 9898600.0 201000.0 0.17 1.019644E7 216000.0 0.18 7614360.0 -595882.5 -0.501065469471699 -0.0861 -0.1538 3187980 PK04_103174 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I17 compound treatment 1.028272E7 585000.0 0.5 1.12732E7 1290000.0 1.07 8603360.0 393117.5 0.330564506752658 1.1007 0.8949 3070603 PK04_103175 COCC(=C=CC[C@H](O)c1ccc(CO)o1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I18 compound treatment 1.014804E7 450000.0 0.39 1.050708E7 527000.0 0.44 7864760.0 -345482.5 -0.290509204510547 0.3082 0.4726 3187981 PK04_103176 COCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I19 compound treatment 1.026376E7 566000.0 0.49 1.014972E7 169000.0 0.14 8461240.0 250997.5 0.211058690553461 0.4842 0.8816 3070604 PK04_103177 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I20 compound treatment 9539760.0 -158000.0 -0.14 1.020504E7 225000.0 0.19 7590600.0 -619642.5 -0.521044770012741 -0.2718 -0.477 3187982 PK04_103178 CC(C)C(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I21 mock treatment 9766800.0 69100.0 0.06 1.038968E7 409000.0 0.34 8437760.0 227517.5 0.191314836315091 0.3408 0.8645 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I22 mock treatment 9941440.0 244000.0 0.21 9669280.0 -311000.0 -0.26 8117960.0 -92282.5 -0.0775984765226736 -0.0728 -0.213 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I23 compound treatment 8789960.0 -908000.0 -0.78 9389840.0 -591000.0 -0.49 7861840.0 -348402.5 -0.292964573095558 -0.9031 -0.9333 3187983 PK04_103179 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 I24 compound treatment 8409680.0 -1290000.0 -1.11 8624680.0 -1360000.0 -1.12 7644040.0 -566202.5 -0.476108161388444 -1.5643 -0.9484 3070605 PK04_103180 CCCCC(=C)/C(=C/C[C@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cnc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J01 compound treatment 5062480.0 -4640000.0 -3.99 5796920.0 -4180000.0 -3.47 4572760.0 -3637482.5 -3.05868502021387 -6.0729 -0.9942 3187984 PK04_103181 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J02 compound treatment 9687480.0 -10200.0 -0.01 9007680.0 -973000.0 -0.81 7252320.0 -957922.5 -0.805497538826872 -0.9361 -0.8209 3187985 PK04_103182 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J03 compound treatment 8006760.0 -1690000.0 -1.46 8451760.0 -1530000.0 -1.27 6598240.0 -1612002.5 -1.35550010186916 -2.355 -0.9984 3070606 PK04_103183 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J04 compound treatment 8982880.0 -715000.0 -0.62 9461080.0 -519000.0 -0.43 7794760.0 -415482.5 -0.349370780178601 -0.8057 -0.9726 3187986 PK04_103184 CN1CCC(=CC1c2ccc(CN3CCCC3)cc2)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J05 mock treatment 1.031784E7 620000.0 0.53 1.052168E7 541000.0 0.45 8282360.0 72117.5 0.0606421383320122 0.6023 0.8604 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J06 mock treatment 1.00066E7 309000.0 0.27 1.071552E7 735000.0 0.61 8296840.0 86597.5 0.0728180756987753 0.5476 0.8183 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J07 compound treatment 6817680.0 -2880000.0 -2.48 6399120.0 -3580000.0 -2.97 5815160.0 -2395082.5 -2.01397614007116 -4.3092 -0.9879 3187987 PK04_103185 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccccc3OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J08 compound treatment 8979360.0 -718000.0 -0.62 8663040.0 -1320000.0 -1.09 6928080.0 -1282162.5 -1.0781443573213 -1.6104 -0.973 3070607 PK04_103186 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3ccc(CN4CCCC4)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J09 compound treatment 9673240.0 -24500.0 -0.02 9858840.0 -122000.0 -0.1 8249880.0 39637.5 0.0333303672220353 -0.0512 -0.4724 3187988 PK04_103187 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J10 compound treatment 1.047956E7 782000.0 0.67 1.041304E7 433000.0 0.36 8223000.0 12757.5 0.0107275221655028 0.6018 0.7891 3070608 PK04_103188 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J11 compound treatment 1.0389E7 691000.0 0.59 1.025856E7 278000.0 0.23 8050560.0 -159682.5 -0.134273765094485 0.3991 0.6121 3187989 PK04_103189 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J12 compound treatment 1.047556E7 778000.0 0.67 1.051148E7 531000.0 0.44 8438200.0 227957.5 0.191684823362147 0.7515 0.912 3070609 PK04_103190 CN1CCC(=CC1C2CC2)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J13 compound treatment 1.054576E7 848000.0 0.73 9885160.0 -95400.0 -0.08 8414840.0 204597.5 0.172041874682066 0.475 0.63 3187990 PK04_103191 COCC(=C)C(=O)CC[C@@H](OC(=O)c1ccccc1c2ccccc2C(=O)O)c3ccc(CO)o3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J14 compound treatment 9809520.0 112000.0 0.1 9133840.0 -847000.0 -0.7 8077800.0 -132442.5 -0.111368203363088 -0.4143 -0.5773 3187991 PK04_103192 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J15 compound treatment 8557040.0 -1140000.0 -0.98 8072360.0 -1910000.0 -1.58 5803160.0 -2407082.5 -2.02406669589996 -2.6493 -0.9631 3070610 PK04_103193 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J16 compound treatment 1.041808E7 720000.0 0.62 1.024028E7 260000.0 0.22 8207280.0 -2962.5 -0.00249110597023727 0.4809 0.7327 3187992 PK04_103194 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J17 compound treatment 8372520.0 -1330000.0 -1.14 7628880.0 -2350000.0 -1.95 6376240.0 -1834002.5 -1.54217538470213 -2.6752 -0.9778 3070654 PK04_103195 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J18 compound treatment 1.001744E7 320000.0 0.28 9603240.0 -377000.0 -0.31 8116920.0 -93322.5 -0.0784729913611704 -0.0671 -0.1583 3187993 PK04_103196 CN1C(C2CC2)C3C4C(C1C=C3CCCO)C(=O)N(C(=O)N)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J19 compound treatment 9493080.0 -205000.0 -0.18 1.003092E7 50400.0 0.04 7727040.0 -483202.5 -0.406315150239181 -0.3121 -0.7017 3070655 PK04_103197 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J20 compound treatment 9643360.0 -54400.0 -0.05 1.006544E7 84900.0 0.07 7471320.0 -738922.5 -0.621344894951104 -0.3451 -0.5503 3187994 PK04_103198 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C3CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J21 mock treatment 9925040.0 227000.0 0.2 9818720.0 -162000.0 -0.13 8498280.0 288037.5 0.242204872878385 0.1753 0.517 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J22 mock treatment 9602760.0 -95000.0 -0.08 9700600.0 -280000.0 -0.23 7726720.0 -483522.5 -0.406584231727949 -0.416 -0.8752 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J23 compound treatment 6800120.0 -2900000.0 -2.49 7317800.0 -2660000.0 -2.21 3919080.0 -4291162.5 -3.6083512313952 -4.7984 -0.9771 3187995 PK04_103199 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 J24 compound treatment 8504120.0 -1190000.0 -1.03 8613800.0 -1370000.0 -1.13 6768200.0 -1442042.5 -1.21258419614713 -1.9478 -0.9977 3070656 PK04_103200 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)CCCO)C(=O)OCCS(=O)(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K01 compound treatment 8128080.0 -1570000.0 -1.35 8733840.0 -1250000.0 -1.03 6623280.0 -1586962.5 -1.33444447537305 -2.1475 -0.9932 3187996 PK04_103201 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K02 compound treatment 6857880.0 -2840000.0 -2.44 8436720.0 -1540000.0 -1.28 6928480.0 -1281762.5 -1.07780800546034 -2.7728 -0.936 3187997 PK04_103202 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2cccc(OCCO)c2)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K03 compound treatment 8958720.0 -739000.0 -0.64 9101400.0 -879000.0 -0.73 7330160.0 -880082.5 -0.740043466683996 -1.2155 -0.9978 3070657 PK04_103203 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K04 compound treatment 7478560.0 -2220000.0 -1.91 8448400.0 -1530000.0 -1.27 7102600.0 -1107642.5 -0.931394040384315 -2.3742 -0.9589 3187998 PK04_103204 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K05 compound treatment 9112560.0 -585000.0 -0.5 1.003176E7 51200.0 0.04 7611480.0 -598762.5 -0.503487202870613 -0.5569 -0.7806 3070658 PK04_103205 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K06 compound treatment 9111840.0 -586000.0 -0.5 9277840.0 -703000.0 -0.58 6873280.0 -1336962.5 -1.12422456227286 -1.2767 -0.9367 3187999 PK04_103206 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K07 mock treatment 1.023304E7 535000.0 0.46 1.007488E7 94400.0 0.08 8564800.0 354557.5 0.298140187356084 0.4833 0.8719 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K08 mock treatment 9992920.0 295000.0 0.25 1.022424E7 244000.0 0.2 8476920.0 266677.5 0.224243683503105 0.3929 0.9956 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K09 compound treatment 9680560.0 -17200.0 -0.01 9814040.0 -166000.0 -0.14 8227280.0 17037.5 0.014326487077778 -0.08 -0.5729 3188000 PK04_103207 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K10 compound treatment 9035680.0 -662000.0 -0.57 9613200.0 -367000.0 -0.3 7410360.0 -799882.5 -0.672604918561455 -0.8932 -0.9577 3070659 PK04_103208 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccc(OCCO)cc2)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K11 compound treatment 9800960.0 103000.0 0.09 1.01556E7 175000.0 0.15 7799800.0 -410442.5 -0.345132746730501 -0.0641 -0.1666 3188108 PK04_103209 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K12 compound treatment 9540200.0 -158000.0 -0.14 1.01602E7 180000.0 0.15 7899600.0 -310642.5 -0.261212957420905 -0.143 -0.4335 3188109 PK04_103210 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K13 compound treatment 1.0458E7 760000.0 0.65 9836880.0 -144000.0 -0.12 8343760.0 133517.5 0.112272148989419 0.3738 0.5542 3070660 PK04_103211 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K14 compound treatment 1.018932E7 492000.0 0.42 1.073712E7 757000.0 0.63 8640960.0 430717.5 0.362181581682927 0.8158 0.9721 3188110 PK04_103212 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K15 mock treatment 1.014E7 442000.0 0.38 9888440.0 -92100.0 -0.08 8008680.0 -201562.5 -0.169489804937029 0.0778 0.1837 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K16 mock treatment 9796920.0 99200.0 0.09 1.052472E7 544000.0 0.45 8395200.0 184957.5 0.155526998308915 0.3997 0.8241 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K17 compound treatment 9855080.0 157000.0 0.14 9741080.0 -239000.0 -0.2 8066920.0 -143322.5 -0.120516973981209 -0.1061 -0.3944 3070661 PK04_103213 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K18 compound treatment 9927320.0 230000.0 0.2 1.060404E7 624000.0 0.52 8387200.0 176957.5 0.148799961089708 0.4986 0.8697 3188111 PK04_103214 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K19 compound treatment 9654400.0 -43300.0 -0.04 9407120.0 -573000.0 -0.48 7289400.0 -920842.5 -0.774317721315852 -0.7432 -0.8171 3188112 PK04_103215 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K20 compound treatment 9547760.0 -150000.0 -0.13 9837920.0 -143000.0 -0.12 7831920.0 -378322.5 -0.318123692295389 -0.3265 -0.8991 3070662 PK04_103216 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K21 compound treatment 9562320.0 -135000.0 -0.12 9291160.0 -689000.0 -0.57 7198720.0 -1011522.5 -0.850568688195553 -0.8885 -0.8614 3188113 PK04_103217 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K22 compound treatment 9818680.0 121000.0 0.1 8919760.0 -1060000.0 -0.88 7684280.0 -525962.5 -0.442271164175837 -0.7033 -0.7101 3188114 PK04_103218 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K23 mock treatment 9921400.0 224000.0 0.19 1.003504E7 54500.0 0.05 7627400.0 -582842.5 -0.490100398804393 -0.1457 -0.2757 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 K24 mock treatment 8461720.0 -1240000.0 -1.06 8413440.0 -1570000.0 -1.3 7259000.0 -951242.5 -0.799880462748835 -1.8265 -0.9817 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L01 compound treatment 3257880.0 -6440000.0 -5.54 3578200.0 -6400000.0 -5.31 3564920.0 -4645322.5 -3.90615716908945 -8.5215 -0.9894 3070663 PK04_103219 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L02 compound treatment 6123880.0 -3570000.0 -3.08 5715800.0 -4260000.0 -3.54 4983920.0 -3226322.5 -2.71294894233277 -5.3847 -0.9942 3188115 PK04_103220 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L03 compound treatment 4504880.0 -5190000.0 -4.47 4805800.0 -5170000.0 -4.29 3448000.0 -4762242.5 -4.00447281804815 -7.3707 -0.999 3070664 PK04_103221 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2cccc(OCCO)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L04 compound treatment 8883960.0 -814000.0 -0.7 9153360.0 -827000.0 -0.69 7667160.0 -543082.5 -0.456667023824939 -1.0642 -0.9839 3188116 PK04_103222 CC1C=C(CCCO)C=C(C(=O)OCCS(=O)(=O)C)C(=CN1Cc2cccc(OC(F)(F)F)c2)C(=O)OCCS(=O)(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L05 compound treatment 2731160.0 -6970000.0 -6.0 2982440.0 -7000000.0 -5.81 3978040.0 -4232202.5 -3.55877296708965 -8.868 -0.9774 3070665 PK04_103223 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L06 compound treatment 9572840.0 -125000.0 -0.11 7677160.0 -2300000.0 -1.91 6491240.0 -1719002.5 -1.44547422467605 -1.9998 -0.8338 3188117 PK04_103224 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L07 mock treatment 8742360.0 -955000.0 -0.82 9469120.0 -511000.0 -0.42 8354320.0 144077.5 0.121151838118771 -0.6497 -0.6963 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L08 mock treatment 1.00668E7 369000.0 0.32 1.001736E7 36800.0 0.03 8519440.0 309197.5 0.259997886323186 0.3512 0.8531 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L09 compound treatment 8219000.0 -1480000.0 -1.27 6535520.0 -3440000.0 -2.86 6648360.0 -1561882.5 -1.31335521369084 -3.143 -0.9263 3188118 PK04_103225 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L10 compound treatment 9988240.0 291000.0 0.25 1.013196E7 151000.0 0.13 8206240.0 -4002.5 -0.00336562080873406 0.215 0.7681 3188119 PK04_103226 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L11 compound treatment 5456920.0 -4240000.0 -3.65 4316120.0 -5660000.0 -4.7 2893200.0 -5317042.5 -4.4709928492001 -7.4015 -0.9945 3070666 PK04_103227 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccccc2OCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L12 compound treatment 9019720.0 -678000.0 -0.58 9247520.0 -733000.0 -0.61 7028600.0 -1181642.5 -0.993619134661971 -1.2616 -0.9683 3188120 PK04_103228 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L13 compound treatment 9735520.0 37800.0 0.03 1.015296E7 172000.0 0.14 8238520.0 28277.5 0.0237779743707626 0.1151 0.7745 3188121 PK04_103229 CCCCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L14 compound treatment 9047360.0 -650000.0 -0.56 8890200.0 -1090000.0 -0.9 6840120.0 -1370122.5 -1.15210813154647 -1.5105 -0.9633 3188122 PK04_103230 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CO)cc3)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L15 mock treatment 1.007796E7 380000.0 0.33 1.026664E7 286000.0 0.24 8399040.0 188797.5 0.158755976174133 0.4176 0.9616 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L16 mock treatment 9776080.0 78400.0 0.07 1.03944E7 414000.0 0.34 8248680.0 38437.5 0.0323213116391544 0.2558 0.728 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L17 compound treatment 9753960.0 56200.0 0.05 1.022556E7 245000.0 0.2 8340080.0 129837.5 0.109177711868584 0.2083 0.8837 3070709 PK04_103231 CC(C)C(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L18 compound treatment 9104880.0 -593000.0 -0.51 9383920.0 -597000.0 -0.49 7952680.0 -257562.5 -0.216579065471472 -0.7054 -0.9492 3188123 PK04_103232 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L19 compound treatment 9523120.0 -175000.0 -0.15 1.001956E7 39000.0 0.03 8253400.0 43157.5 0.036290263598486 -0.0471 -0.2982 3070710 PK04_103233 COCC(=C)C(=O)CC[C@@H](OC(=O)c1cccnc1)c2ccc(CO)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L20 compound treatment 8005880.0 -1690000.0 -1.46 8757040.0 -1220000.0 -1.01 7351640.0 -858602.5 -0.721981371750428 -1.8435 -0.9621 3188124 PK04_103234 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L21 compound treatment 9623520.0 -74200.0 -0.06 9508240.0 -472000.0 -0.39 7793400.0 -416842.5 -0.350514376505866 -0.4654 -0.8789 3070711 PK04_103235 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L22 compound treatment 8855800.0 -842000.0 -0.72 9882440.0 -98100.0 -0.08 7615800.0 -594442.5 -0.499854602772242 -0.7539 -0.8528 3188125 PK04_103236 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L23 mock treatment 8880240.0 -817000.0 -0.7 9654600.0 -326000.0 -0.27 7805520.0 -404722.5 -0.340322915118769 -0.7588 -0.9175 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 L24 mock treatment 7929120.0 -1770000.0 -1.52 8280360.0 -1700000.0 -1.41 7722640.0 -487602.5 -0.410015020709744 -1.9298 -0.9123 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M01 compound treatment 7814680.0 -1880000.0 -1.62 7878240.0 -2100000.0 -1.74 6696920.0 -1513322.5 -1.27252209777026 -2.6772 -0.9918 3070712 PK04_103237 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M02 compound treatment 7970840.0 -1730000.0 -1.49 8366320.0 -1610000.0 -1.34 6969920.0 -1240322.5 -1.04296195266485 -2.2333 -0.9899 3188126 PK04_103238 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccc(OCCO)cc3)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M03 compound treatment 7819520.0 -1880000.0 -1.62 9013520.0 -967000.0 -0.8 6691560.0 -1518682.5 -1.27702921270713 -2.1337 -0.9652 3070713 PK04_103239 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M04 compound treatment 7886320.0 -1810000.0 -1.56 8291680.0 -1690000.0 -1.4 6394520.0 -1815722.5 -1.52680410465625 -2.5904 -0.999 3188127 PK04_103240 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M05 compound treatment 8573800.0 -1120000.0 -0.97 9116400.0 -864000.0 -0.72 7349080.0 -861162.5 -0.724134023660574 -1.3904 -0.9897 3188128 PK04_103241 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M06 compound treatment 9533840.0 -164000.0 -0.14 9443240.0 -537000.0 -0.45 7375360.0 -834882.5 -0.702035706395482 -0.7441 -0.8822 3070714 PK04_103242 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M07 compound treatment 8961360.0 -736000.0 -0.63 9174120.0 -806000.0 -0.67 7183640.0 -1026602.5 -0.863249153353757 -1.2505 -0.9904 3188237 PK04_103243 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M08 compound treatment 8855480.0 -842000.0 -0.72 9083680.0 -897000.0 -0.74 6480960.0 -1729282.5 -1.45411846750273 -1.6876 -0.9444 3070715 PK04_103244 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccc(CO)o2)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M09 mock treatment 9879320.0 182000.0 0.16 9827480.0 -153000.0 -0.13 7553840.0 -656402.5 -0.551955506034993 -0.3017 -0.5135 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M10 mock treatment 9909760.0 212000.0 0.18 1.015372E7 173000.0 0.14 7780360.0 -429882.5 -0.361479447173172 -0.0204 -0.0474 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M11 compound treatment 9900080.0 202000.0 0.17 9821720.0 -159000.0 -0.13 7862080.0 -348162.5 -0.292762761978981 -0.1445 -0.3957 3188238 PK04_103245 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M12 compound treatment 9385600.0 -312000.0 -0.27 9680920.0 -300000.0 -0.25 7659280.0 -550962.5 -0.463293155485857 -0.5661 -0.9588 3188239 PK04_103246 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M13 mock treatment 9879600.0 182000.0 0.16 9625320.0 -355000.0 -0.29 8594800.0 384557.5 0.323366576928107 0.107 0.2302 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M14 mock treatment 9588160.0 -110000.0 -0.09 1.04902E7 510000.0 0.42 8244680.0 34437.5 0.0289577930295514 0.2064 0.4754 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M15 compound treatment 9372440.0 -325000.0 -0.28 9767360.0 -213000.0 -0.18 7893320.0 -316922.5 -0.266493681637981 -0.4176 -0.9825 3070716 PK04_103247 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M16 compound treatment 9330200.0 -368000.0 -0.32 9756280.0 -224000.0 -0.19 8293360.0 83117.5 0.0698918145084206 -0.2497 -0.6684 3188240 PK04_103248 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(CO)o1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M17 compound treatment 8982520.0 -715000.0 -0.62 9881520.0 -99000.0 -0.08 8255520.0 45277.5 0.0380729284615756 -0.3808 -0.6121 3070717 PK04_103249 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M18 compound treatment 9392520.0 -305000.0 -0.26 9560960.0 -420000.0 -0.35 7611800.0 -598442.5 -0.503218121381845 -0.6431 -0.9659 3188241 PK04_103250 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M19 compound treatment 9164440.0 -533000.0 -0.46 9769960.0 -211000.0 -0.17 7878520.0 -331722.5 -0.278938700493513 -0.5269 -0.9329 3188242 PK04_103251 CCCCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M20 compound treatment 9527840.0 -170000.0 -0.15 9620400.0 -360000.0 -0.3 7838240.0 -372002.5 -0.312809332892216 -0.4375 -0.9582 3070718 PK04_103252 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)C)c2ccccc2OCCO)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M21 compound treatment 9312240.0 -385000.0 -0.33 9023040.0 -957000.0 -0.79 7447480.0 -762762.5 -0.641391465864339 -1.0204 -0.9506 3188243 PK04_103253 CC(C)C(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M22 compound treatment 8879720.0 -818000.0 -0.7 8876360.0 -1100000.0 -0.92 7273760.0 -936482.5 -0.7874690790794 -1.3899 -0.9941 3188244 PK04_103254 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccccc1OCCO)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M23 compound treatment 8977840.0 -720000.0 -0.62 9246400.0 -734000.0 -0.61 7602800.0 -607442.5 -0.510786038253452 -1.0042 -0.9965 3188245 PK04_103255 COCC(=C=CC[C@H](O)c1ccc(OCCO)cc1)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 M24 compound treatment 7638440.0 -2060000.0 -1.77 7660200.0 -2320000.0 -1.92 6455000.0 -1755242.5 -1.47594770327905 -2.9867 -0.9942 3070768 PK04_103256 COCC(=C)/C(=C/C[C@@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N01 compound treatment 8149320.0 -1550000.0 -1.33 7974600.0 -2010000.0 -1.66 7547520.0 -662722.5 -0.557269865438166 -2.0519 -0.9312 3188246 PK04_103257 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N02 compound treatment 8349280.0 -1350000.0 -1.16 8498160.0 -1480000.0 -1.23 7637080.0 -573162.5 -0.481960683769154 -1.6583 -0.9432 3188247 PK04_103258 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)CCCO)C(=O)OCCS(=O)(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N03 compound treatment 8478480.0 -1220000.0 -1.05 9111600.0 -869000.0 -0.72 7484240.0 -726002.5 -0.610480729842087 -1.3745 -0.9735 3070772 PK04_103259 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N04 compound treatment 7905160.0 -1790000.0 -1.54 7990000.0 -1990000.0 -1.65 6874480.0 -1335762.5 -1.12321550668998 -2.4926 -0.9877 3188248 PK04_103260 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N05 compound treatment 8998040.0 -700000.0 -0.6 9548280.0 -432000.0 -0.36 7728520.0 -481722.5 -0.405070648353628 -0.7885 -0.9741 3188249 PK04_103261 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N06 compound treatment 7436280.0 -2260000.0 -1.95 8038880.0 -1940000.0 -1.61 6613680.0 -1596562.5 -1.3425169200361 -2.8287 -0.9888 3188250 PK04_103262 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N07 compound treatment 9013600.0 -684000.0 -0.59 9258600.0 -722000.0 -0.6 8152400.0 -57842.5 -0.0486385812939913 -0.7138 -0.8485 3070060 PK04_103263 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N08 compound treatment 9488080.0 -210000.0 -0.18 8984320.0 -996000.0 -0.83 6867720.0 -1342522.5 -1.12889985314021 -1.2331 -0.8741 3188251 PK04_103264 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CN4CCCC4)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N09 mock treatment 8946640.0 -751000.0 -0.65 9586440.0 -394000.0 -0.33 8145480.0 -64762.5 -0.0544574684886046 -0.5934 -0.8169 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N10 mock treatment 9834560.0 137000.0 0.12 9819120.0 -161000.0 -0.13 8101080.0 -109162.5 -0.0917925250551985 -0.0623 -0.3106 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N11 compound treatment 9607960.0 -89800.0 -0.08 9760200.0 -220000.0 -0.18 7724760.0 -485482.5 -0.408232355846654 -0.3858 -0.85 3070061 PK04_103265 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N12 compound treatment 9035320.0 -662000.0 -0.57 1.460616E7 4630000.0 3.84 8705720.0 495477.5 0.4166369479724 2.1269 0.5451 3188252 PK04_103266 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N13 mock treatment 9762640.0 64900.0 0.06 9977120.0 -3400.0 0.0 7620200.0 -590042.5 -0.496154732301679 -0.2558 -0.5124 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N14 mock treatment 9375560.0 -322000.0 -0.28 9733520.0 -247000.0 -0.2 7949920.0 -260322.5 -0.218899893312098 -0.4048 -0.9911 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N15 compound treatment 9557880.0 -140000.0 -0.12 9644800.0 -336000.0 -0.28 7582080.0 -628162.5 -0.528209064651196 -0.5352 -0.8787 3070062 PK04_103267 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N16 compound treatment 9216520.0 -481000.0 -0.41 1.017712E7 197000.0 0.16 7896760.0 -313482.5 -0.263601055633723 -0.2971 -0.5744 3188253 PK04_103268 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N17 compound treatment 8878600.0 -819000.0 -0.7 9076720.0 -904000.0 -0.75 7517040.0 -693202.5 -0.582899877243341 -1.1764 -0.9947 3070063 PK04_103269 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N18 compound treatment 9053640.0 -644000.0 -0.55 9060000.0 -921000.0 -0.76 7542880.0 -667362.5 -0.561171547025306 -1.0849 -0.9882 3188254 PK04_103270 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2ccc(CN3CCCC3)cc2)CCCO)C(=O)OCCS(=O)(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N19 compound treatment 9603440.0 -94300.0 -0.08 9712280.0 -268000.0 -0.22 7802880.0 -407362.5 -0.342542837401107 -0.3731 -0.8959 3070064 PK04_103271 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N20 compound treatment 9889080.0 191000.0 0.16 9473400.0 -507000.0 -0.42 7226480.0 -983762.5 -0.827225869044908 -0.6254 -0.6635 3188255 PK04_103272 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N21 compound treatment 9103320.0 -594000.0 -0.51 9080400.0 -900000.0 -0.75 7348640.0 -861602.5 -0.72450401070763 -1.1448 -0.9874 3070065 PK04_103273 CCCCC(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N22 compound treatment 8463680.0 -1230000.0 -1.06 8584240.0 -1400000.0 -1.16 6675560.0 -1534682.5 -1.29048328714554 -2.027 -0.9968 3188256 PK04_103274 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2sc3ccccc3c2Cl)c4ccc(CN5CCCC5)cc4)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N23 compound treatment 9121520.0 -576000.0 -0.5 8832320.0 -1150000.0 -0.95 7018160.0 -1192082.5 -1.00239791823304 -1.415 -0.9632 3070066 PK04_103275 CC(C)C(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 N24 compound treatment 8292400.0 -1410000.0 -1.21 8278320.0 -1700000.0 -1.41 6917560.0 -1292682.5 -1.08699041126455 -2.1411 -0.9942 3188257 PK04_103276 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O01 compound treatment 7916760.0 -1780000.0 -1.53 7164120.0 -2820000.0 -2.34 6617480.0 -1592762.5 -1.33932157735697 -3.0071 -0.9704 3188258 PK04_103277 CCCCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O02 compound treatment 6886240.0 -2810000.0 -2.42 8051240.0 -1930000.0 -1.6 6598200.0 -1612042.5 -1.35553373705526 -3.1036 -0.9692 3070067 PK04_103278 CC(C)C(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O03 compound treatment 8416080.0 -1280000.0 -1.1 9244680.0 -736000.0 -0.61 7566280.0 -643962.5 -0.541494963159128 -1.3019 -0.9489 3188259 PK04_103279 CC(C)C(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O04 compound treatment 8401280.0 -1300000.0 -1.12 8394160.0 -1590000.0 -1.32 6836000.0 -1374242.5 -1.15557255571436 -2.0711 -0.9974 3188369 PK04_103280 CCCCC(=C)/C(=C/C[C@@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cnc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O05 compound treatment 8876760.0 -821000.0 -0.71 9483080.0 -497000.0 -0.41 7795360.0 -414882.5 -0.34886625238716 -0.8476 -0.9529 3070068 PK04_103281 COCC(=C=CC[C@H](O)c1cccc(OCCO)c1)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O06 compound treatment 9065480.0 -632000.0 -0.54 8970760.0 -1010000.0 -0.84 7479760.0 -730482.5 -0.614247870684842 -1.1524 -0.9828 3188370 PK04_103282 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O07 compound treatment 8980120.0 -718000.0 -0.62 9419040.0 -561000.0 -0.47 7910920.0 -299322.5 -0.251694199755728 -0.7708 -0.9476 3070069 PK04_103283 CCCCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O08 compound treatment 7902000.0 -1800000.0 -1.55 7492800.0 -2490000.0 -2.06 5945200.0 -2265042.5 -1.90462815007296 -3.1834 -0.9931 3188371 PK04_103284 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccc(CO)o3)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O09 compound treatment 9504680.0 -193000.0 -0.17 9188960.0 -792000.0 -0.66 7618680.0 -591562.5 -0.497432869373328 -0.7622 -0.907 3188372 PK04_103285 CC(C)C(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O10 compound treatment 9027040.0 -671000.0 -0.58 8640400.0 -1340000.0 -1.11 6914600.0 -1295642.5 -1.08947941503566 -1.6041 -0.9663 3070070 PK04_103286 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(CO)o2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O11 mock treatment 9734400.0 36700.0 0.03 1.016524E7 185000.0 0.15 8105400.0 -104842.5 -0.0881599249568272 0.0558 0.3107 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O12 mock treatment 9768480.0 70800.0 0.06 1.013744E7 157000.0 0.13 7987760.0 -222482.5 -0.187081007265253 0.0023 0.0098 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O13 compound treatment 9138400.0 -559000.0 -0.48 9618600.0 -362000.0 -0.3 7845120.0 -365122.5 -0.307024080883698 -0.6285 -0.9743 3188373 PK04_103287 COCC(=C=CC[C@H](O)c1ccccc1OCCO)C[C@H](O)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O14 compound treatment 8713440.0 -984000.0 -0.85 8323160.0 -1660000.0 -1.37 7054560.0 -1155682.5 -0.971789898885647 -1.8439 -0.9783 3188374 PK04_103288 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3ccccc3OCCO)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O15 compound treatment 9260280.0 -437000.0 -0.38 9953680.0 -26800.0 -0.02 8130120.0 -80122.5 -0.0673733799494803 -0.2691 -0.7024 3070071 PK04_103289 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O16 compound treatment 8157440.0 -1540000.0 -1.33 7919360.0 -2060000.0 -1.71 6676520.0 -1533722.5 -1.28967604267923 -2.4971 -0.9914 3188375 PK04_103290 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccccc2OCCO)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O17 compound treatment 8203800.0 -1490000.0 -1.29 9329480.0 -651000.0 -0.54 6895040.0 -1315202.5 -1.10592702103662 -1.6926 -0.951 3070072 PK04_103291 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2ccc(OCCO)cc2)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O18 compound treatment 9420640.0 -277000.0 -0.24 1.00416E7 61100.0 0.05 7794880.0 -415362.5 -0.349269874620313 -0.3101 -0.728 3188376 PK04_103292 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O19 compound treatment 9039120.0 -659000.0 -0.57 9310760.0 -670000.0 -0.56 7472200.0 -738042.5 -0.620604920856992 -1.0063 -0.9988 3188377 PK04_103293 COCC(=C)/C(=C/C[C@H](OC(=O)C)c1ccc(OCCO)cc1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O20 compound treatment 7700280.0 -2000000.0 -1.72 9450440.0 -530000.0 -0.44 7798960.0 -411282.5 -0.345839085638518 -1.4461 -0.7999 3070073 PK04_103294 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@@H](OC(=O)c2ccncc2)c3cccc(OCCO)c3)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O21 compound treatment 8897120.0 -801000.0 -0.69 9180560.0 -800000.0 -0.66 7419400.0 -790842.5 -0.665003366503752 -1.1649 -0.9998 3188378 PK04_103295 CCCCC(=C)/C(=C/C[C@H](OC(=O)C)c1cccc(OCCO)c1)/c2cc(ccc2OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O22 compound treatment 7574080.0 -2120000.0 -1.83 7519240.0 -2460000.0 -2.04 6348800.0 -1861442.5 -1.56524912236401 -3.1377 -0.9943 3188379 PK04_103296 CCCCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2cccc(OCCO)c2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O23 compound treatment 8704640.0 -993000.0 -0.85 9052120.0 -928000.0 -0.77 6883240.0 -1327002.5 -1.11584940093495 -1.5823 -0.9873 3070074 PK04_103297 COC(=O)c1ccc(OC)c(c1)/C(=C\C[C@H](OC(=O)C)c2cccc(OCCO)c2)/C(=C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 O24 compound treatment 7456680.0 -2240000.0 -1.93 7444360.0 -2540000.0 -2.1 6600720.0 -1609522.5 -1.35341472033121 -3.1096 -0.9844 3188380 PK04_103298 COCC(=C)/C(=C/C[C@@H](OC(=O)c1ccncc1)c2ccc(OCCO)cc2)/c3cc(ccc3OC)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P01 compound treatment 6789480.0 -2910000.0 -2.5 6452800.0 -3530000.0 -2.93 5889680.0 -2320562.5 -1.95131378837425 -4.2613 -0.9871 3070075 PK04_103299 COCC(=C=CC[C@@H](O)c1ccc(CO)o1)CCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P02 compound treatment 7864760.0 -1830000.0 -1.58 7810680.0 -2170000.0 -1.8 6706640.0 -1503602.5 -1.26434874754892 -2.68 -0.9901 3188381 PK04_103300 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)c3ccc(CO)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P03 compound treatment 7899880.0 -1800000.0 -1.55 7497720.0 -2480000.0 -2.06 6230880.0 -1979362.5 -1.66440565097511 -3.0434 -0.9923 3188382 PK04_103301 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P04 compound treatment 7718280.0 -1980000.0 -1.7 7931440.0 -2050000.0 -1.7 8068920.0 -141322.5 -0.118835214676407 -2.0336 -0.844 3070118 PK04_103302 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P05 compound treatment 7784240.0 -1910000.0 -1.65 7840080.0 -2140000.0 -1.78 8565920.0 355677.5 0.299081972566773 -1.8033 -0.739 3188383 PK04_103303 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P06 compound treatment 8504080.0 -1190000.0 -1.03 8234840.0 -1750000.0 -1.45 1.027984E7 2069597.5 1.74028242640949 -0.4244 -0.1707 3070119 PK04_103304 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cccc(OC(F)(F)F)c3)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P07 compound treatment 8748520.0 -949000.0 -0.82 8596360.0 -1380000.0 -1.15 7332320.0 -877922.5 -0.738227166634811 -1.5608 -0.9811 3188384 PK04_103305 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P08 compound treatment 8917160.0 -781000.0 -0.67 6823840.0 -3160000.0 -2.62 6248080.0 -1962162.5 -1.64994252095382 -2.8523 -0.9006 3188385 PK04_103306 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3ccc(CN4CCCC4)cc3)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P09 compound treatment 7839160.0 -1860000.0 -1.6 7957040.0 -2020000.0 -1.68 6356840.0 -1853402.5 -1.55848844995871 -2.7924 -0.9995 3070120 PK04_103307 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P10 compound treatment 8673240.0 -1020000.0 -0.88 8300520.0 -1680000.0 -1.39 7226680.0 -983562.5 -0.827057693114428 -1.7912 -0.9709 3188386 PK04_103308 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P11 mock treatment 8911680.0 -786000.0 -0.68 8888360.0 -1090000.0 -0.91 7554320.0 -655922.5 -0.551551883801841 -1.2321 -0.9794 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P12 mock treatment 8403360.0 -1290000.0 -1.11 8819040.0 -1160000.0 -0.96 7720480.0 -489762.5 -0.41183132075893 -1.4372 -0.9398 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P13 compound treatment 5000720.0 -4700000.0 -4.04 4494680.0 -5490000.0 -4.55 4499920.0 -3710322.5 -3.11993469409474 -6.7626 -0.9887 3070121 PK04_103309 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P14 compound treatment 8441320.0 -1260000.0 -1.08 9570840.0 -410000.0 -0.34 7161200.0 -1049042.5 -0.88211849275363 -1.3298 -0.9259 3188387 PK04_103310 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P15 compound treatment 8636560.0 -1060000.0 -0.91 1.127528E7 1290000.0 1.07 7883960.0 -326282.5 -0.274364315184453 -0.0655 -0.0456 3188388 PK04_103311 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P16 compound treatment 7793520.0 -1900000.0 -1.64 8390440.0 -1590000.0 -1.32 7559240.0 -651002.5 -0.547414755912029 -2.0238 -0.931 3070122 PK04_103312 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2ccc(CN3CCCC3)cc2)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P17 compound treatment 8076320.0 -1620000.0 -1.4 8076200.0 -1900000.0 -1.58 6654760.0 -1555482.5 -1.30797358391547 -2.4729 -0.9969 3188389 PK04_103313 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P18 compound treatment 8644360.0 -1050000.0 -0.91 8518040.0 -1460000.0 -1.21 7788040.0 -422202.5 -0.355021491442734 -1.4288 -0.9185 3188390 PK04_103314 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P19 compound treatment 8488640.0 -1210000.0 -1.04 8373760.0 -1610000.0 -1.33 6816240.0 -1394002.5 -1.1721883376458 -2.0471 -0.9949 3070123 PK04_103315 CC(C)C(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P20 compound treatment 8396000.0 -1300000.0 -1.12 8166280.0 -1810000.0 -1.51 7301400.0 -908842.5 -0.764227165487042 -1.957 -0.966 3188503 PK04_103316 COP(=O)(OC)/N=C\1/CC(=CC(C)N1Cc2cccc(OC(F)(F)F)c2)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P21 compound treatment 8662440.0 -1040000.0 -0.89 8148400.0 -1830000.0 -1.52 7479400.0 -730842.5 -0.614550587359706 -1.7467 -0.9361 3188504 PK04_103317 COCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)COCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P22 compound treatment 8193760.0 -1500000.0 -1.29 8049360.0 -1930000.0 -1.6 6733400.0 -1476842.5 -1.24184680805068 -2.3892 -0.9934 3070124 PK04_103318 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cc3OCOc3cc2Br)c4ccc(CN5CCCC5)cc4)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P23 compound treatment 7115560.0 -2580000.0 -2.22 7613400.0 -2370000.0 -1.96 6357400.0 -1852842.5 -1.55801755735336 -3.3163 -0.99 3188505 PK04_103319 CCCCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2103 P24 compound treatment 5676200.0 -4020000.0 -3.46 6585680.0 -3390000.0 -2.82 5497920.0 -2712322.5 -2.28073680099877 -4.941 -0.986 3188506 PK04_103320 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)c5ccc(CO)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A01 mock treatment 6008120.0 -3180000.0 -2.74 6267720.0 -2880000.0 -2.39 5988840.0 -2983927.76470588 -2.50912414157487 -4.4092 -0.9984 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A02 mock treatment 7298160.0 -1890000.0 -1.63 7202320.0 -1950000.0 -1.61 6980440.0 -1992327.76470588 -1.67530787825427 -2.8392 -0.9999 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A03 mock treatment 7536880.0 -1650000.0 -1.42 8031160.0 -1120000.0 -0.93 7510160.0 -1462607.76470588 -1.22987710878454 -2.0664 -0.9857 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A04 mock treatment 8039640.0 -1150000.0 -0.99 7815480.0 -1330000.0 -1.11 8095720.0 -877047.76470588 -0.737491619524748 -1.6356 -0.987 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A05 mock treatment 7633480.0 -1560000.0 -1.34 8738840.0 -410000.0 -0.34 7445080.0 -1527687.76470588 -1.28460155656278 -1.711 -0.907 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A06 mock treatment 8461520.0 -728000.0 -0.63 8283080.0 -866000.0 -0.72 7266160.0 -1706607.76470588 -1.43505174397033 -1.6047 -0.9316 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A07 mock treatment 7998680.0 -1190000.0 -1.02 8172600.0 -976000.0 -0.81 7821800.0 -1150967.76470588 -0.967825373910366 -1.6179 -0.9953 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A08 mock treatment 8432280.0 -757000.0 -0.65 8359560.0 -789000.0 -0.65 7728680.0 -1244087.76470588 -1.04612808714193 -1.3581 -0.9732 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A09 mock treatment 8713200.0 -476000.0 -0.41 8276760.0 -872000.0 -0.72 8049720.0 -923047.76470588 -0.776172083535183 -1.1023 -0.9692 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A10 mock treatment 8339120.0 -850000.0 -0.73 8136760.0 -1010000.0 -0.84 8291400.0 -681367.76470588 -0.572948289142966 -1.2379 -0.9885 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A11 mock treatment 9538320.0 349000.0 0.3 8766680.0 -382000.0 -0.32 7951960.0 -1020807.76470588 -0.858376478353882 -0.5051 -0.5245 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A12 mock treatment 6942040.0 -2250000.0 -1.93 7701880.0 -1450000.0 -1.2 6508040.0 -2464727.76470588 -2.0725394260484 -3.0062 -0.9765 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A13 mock treatment 8567320.0 -622000.0 -0.54 8675800.0 -473000.0 -0.39 8936160.0 -36607.7647058796 -0.0307827244610491 -0.5533 -0.8328 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A14 mock treatment 8812120.0 -377000.0 -0.32 8737760.0 -411000.0 -0.34 8362440.0 -610327.76470588 -0.513212198636416 -0.6805 -0.9772 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A15 mock treatment 8306200.0 -883000.0 -0.76 8323640.0 -825000.0 -0.68 9528040.0 555272.23529412 0.466917124201916 -0.5644 -0.502 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A16 mock treatment 8106760.0 -1080000.0 -0.93 8965160.0 -183000.0 -0.15 1.04616E7 1488832.23529412 1.25192873249717 0.097 0.0619 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A17 mock treatment 8418520.0 -771000.0 -0.66 8527960.0 -621000.0 -0.51 8012960.0 -959807.76470588 -0.807082819557435 -1.1463 -0.9841 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A18 mock treatment 8418520.0 -771000.0 -0.66 8132440.0 -1020000.0 -0.84 7853680.0 -1119087.76470588 -0.941018130591829 -1.413 -0.9902 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A19 mock treatment 8651720.0 -538000.0 -0.46 8001560.0 -1150000.0 -0.95 8391640.0 -581127.76470588 -0.488658512786314 -1.0987 -0.9427 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A20 mock treatment 8470080.0 -719000.0 -0.62 7908080.0 -1240000.0 -1.03 7732360.0 -1240407.76470588 -1.04303365002109 -1.5538 -0.9768 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A21 mock treatment 8010720.0 -1180000.0 -1.01 8471000.0 -678000.0 -0.56 7997440.0 -975327.76470588 -0.820133271762695 -1.3837 -0.9742 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A22 mock treatment 8267200.0 -922000.0 -0.79 7949280.0 -1200000.0 -0.99 8066200.0 -906567.76470588 -0.762314386863619 -1.4728 -0.9927 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A23 mock treatment 7216520.0 -1970000.0 -1.7 7289920.0 -1860000.0 -1.54 7036280.0 -1936487.76470588 -1.62835315846421 -2.8107 -0.9992 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 A24 mock treatment 6197920.0 -2990000.0 -2.57 6510480.0 -2640000.0 -2.19 7262760.0 -1710007.76470588 -1.43791073478849 -3.5802 -0.9749 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B01 mock treatment 7069320.0 -2120000.0 -1.82 7373320.0 -1780000.0 -1.47 7457720.0 -1515047.76470588 -1.27397283775644 -2.6393 -0.989 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B02 mock treatment 8238120.0 -951000.0 -0.82 8594080.0 -555000.0 -0.46 8371840.0 -600927.76470588 -0.505307929903849 -1.03 -0.9659 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B03 compound treatment 4890760.0 -4300000.0 -3.7 4684960.0 -4460000.0 -3.7 4628360.0 -4344407.76470588 -3.65312409107307 -6.383 -1.0 2277 HSCI1_000001 CCc1nc([nH]c1c2ccncc2)c3ccc(OC)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B04 compound treatment 6170920.0 -3020000.0 -2.6 6404000.0 -2740000.0 -2.28 5879800.0 -3092967.76470588 -2.60081365887265 -4.316 -0.9981 656 HSCI1_000002 Oc1c(Br)cc(/C=C/2\C(=O)Nc3ccc(I)cc23)cc1Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B05 compound treatment 9117520.0 -71900.0 -0.06 8747840.0 -401000.0 -0.33 6880720.0 -2092047.76470588 -1.75916039719168 -1.2433 -0.6941 2114187 HSCI1_000003 CCOC(=O)c1cccc(NC(=O)CBr)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B06 compound treatment 9182360.0 -7030.0 -0.01 1.006752E7 919000.0 0.76 9130480.0 157712.23529412 0.132617009593468 0.5132 0.6632 1362420 HSCI1_000004 Oc1c(I)cc(Cl)cc1C(=O)Nc2cc(ccc2Cl)S(=O)(=O)c3ccc(Cl)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B07 compound treatment 9320760.0 131000.0 0.11 9361560.0 213000.0 0.18 8390080.0 -582687.76470588 -0.489970285044059 -0.1156 -0.2169 3175973 HSCI1_000005 COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B08 compound treatment 9289840.0 100000.0 0.09 8516840.0 -632000.0 -0.52 8451800.0 -520967.76470588 -0.438071192897884 -0.5056 -0.7343 3175974 HSCI1_000006 CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1CCC(O)C(O)C1O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B09 compound treatment 9964040.0 775000.0 0.67 9985320.0 837000.0 0.69 9514400.0 541632.23529412 0.455447525743169 1.0486 0.9848 9 HSCI1_000007 [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc34)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B10 compound treatment 3045160.0 -6140000.0 -5.29 4000880.0 -5150000.0 -4.27 2695560.0 -6277207.76470588 -5.27837628323326 -8.566 -0.9954 571 HSCI1_000008 CCCCCCCCCCCCCCCCCCOC[C@H](COC(=O)OC1C(O)C(O)C(O)C(CO)C1O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B11 mock treatment 9477280.0 288000.0 0.25 9264520.0 116000.0 0.1 9465640.0 492872.23529412 0.414446233892108 0.4378 0.8893 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B12 mock treatment 9623760.0 434000.0 0.37 7805680.0 -1340000.0 -1.11 7540040.0 -1432727.76470588 -1.20475162477081 -1.1229 -0.6672 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B13 mock treatment 9894080.0 705000.0 0.61 9930160.0 782000.0 0.65 9447400.0 474632.23529412 0.399108589032318 0.9549 0.981 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B14 mock treatment 9675840.0 486000.0 0.42 9789680.0 641000.0 0.53 1.007812E7 1105352.23529412 0.929468203394529 1.0854 0.944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B15 compound treatment 9147880.0 -41500.0 -0.04 9129000.0 -19600.0 -0.02 8619160.0 -353607.76470588 -0.297341574272092 -0.2017 -0.6725 3055039 HSCI1_000009 Cn1cnc2nc(NCCO)nc(NCc3ccccc3)c12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B16 compound treatment 8708600.0 -481000.0 -0.41 9069360.0 -79300.0 -0.07 8055680.0 -917087.76470588 -0.771160440806875 -0.7221 -0.8228 3175975 HSCI1_000010 CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1C(O)C(O)C(O)CC1OC)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B17 compound treatment 9621560.0 432000.0 0.37 1.004644E7 898000.0 0.74 9095400.0 122632.23529412 0.103118951387249 0.7043 0.8396 3055043 HSCI1_000011 CCCCCCCCCCCCCCC[C@@H](O)[C@H](N)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B18 compound treatment 8717320.0 -472000.0 -0.41 9223080.0 74500.0 0.06 8752120.0 -220647.76470588 -0.185538215688886 -0.306 -0.6787 2326 HSCI1_000012 CCCCCC(=O)O[C@@H]1[C@@H](OC(=O)/C(=C\C)/C)C(=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(=O)C)[C@@H]12)OC(=O)CCC)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B19 compound treatment 9370480.0 181000.0 0.16 9362360.0 214000.0 0.18 9102640.0 129872.23529412 0.10920692007063 0.2554 0.9819 2026 HSCI1_000013 CCCCCCCCCCNc1cc(CO)c2cc[nH]c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B20 compound treatment 363760.0 -8830000.0 -7.6 383320.0 -8770000.0 -7.27 435360.0 -8537407.76470588 -7.17893247358947 -12.7283 -0.9997 193 HSCI1_000014 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B21 compound treatment 4112160.0 -5080000.0 -4.37 7451000.0 -1700000.0 -1.41 4170600.0 -4802167.76470588 -4.03804516075604 -5.6673 -0.9269 3055048 HSCI1_000015 Nc1nc(Cl)nc2n(cnc12)C3OC(CO)[C@H](O)[C@H]3F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B22 compound treatment 3565480.0 -5620000.0 -4.84 4011040.0 -5140000.0 -4.26 3038720.0 -5934047.76470588 -4.98982002171542 -8.136 -0.9978 3175977 HSCI1_000016 CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@]41OC(=O)CCCCCCCCC)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B23 mock treatment 8442480.0 -747000.0 -0.64 8370720.0 -778000.0 -0.65 8410440.0 -562327.76470588 -0.472849975321179 -1.0167 -0.9907 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 B24 mock treatment 7288120.0 -1900000.0 -1.64 8010840.0 -1140000.0 -0.94 7597080.0 -1375687.76470588 -1.15678784939787 -2.1575 -0.974 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C01 mock treatment 8189920.0 -999000.0 -0.86 8003680.0 -1140000.0 -0.95 7931360.0 -1041407.76470588 -0.875698599193338 -1.5506 -0.999 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C02 mock treatment 8435320.0 -754000.0 -0.65 8495800.0 -653000.0 -0.54 8807760.0 -165007.76470588 -0.138751671829307 -0.7675 -0.896 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C03 compound treatment 8653800.0 -536000.0 -0.46 7876240.0 -1270000.0 -1.06 6562280.0 -2410487.76470588 -2.02693011370218 -2.0458 -0.8775 2257 HSCI1_000017 COc1ccc(cc1)C(=O)CBr 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C04 compound treatment 2385360.0 -6800000.0 -5.86 2333680.0 -6810000.0 -5.65 2249440.0 -6723327.76470588 -5.65350951376229 -9.9089 -0.9999 561 HSCI1_000018 C[C@@H](NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C05 compound treatment 383960.0 -8810000.0 -7.58 395160.0 -8750000.0 -7.26 251680.0 -8721087.76470588 -7.33338524814245 -12.8018 -0.9998 2256 HSCI1_000019 Oc1ccc(cc1)C(=O)CBr 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C06 compound treatment 9243840.0 54400.0 0.05 8776760.0 -372000.0 -0.31 8834680.0 -138087.76470588 -0.116115191586679 -0.2181 -0.6551 1000099 HSCI1_000020 C[C@H](NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C07 compound treatment 7811920.0 -1380000.0 -1.19 8484600.0 -664000.0 -0.55 5135760.0 -3837007.76470588 -3.22646175544492 -2.8653 -0.8231 2258 HSCI1_000021 OC(=O)COc1ccc(cc1)C(=O)CBr 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C08 compound treatment 1.0034E7 845000.0 0.73 9683520.0 535000.0 0.44 9390240.0 417472.23529412 0.35104390810109 0.8785 0.9537 2227 HSCI1_000022 CCCCCCCCCCCCCCCC(=O)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C09 compound treatment 9994000.0 805000.0 0.69 9799960.0 651000.0 0.54 9685080.0 712312.23529412 0.598968864814932 1.0576 0.9948 2147 HSCI1_000023 CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(F)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C10 compound treatment 4288480.0 -4900000.0 -4.22 4352920.0 -4800000.0 -3.98 4095960.0 -4876807.76470588 -4.10080841801123 -7.0997 -0.9997 617 HSCI1_000024 COc1cc(OC)c(/C=C\2/C(=O)Nc3ccccc23)c(OC)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C11 mock treatment 1.012828E7 939000.0 0.81 9913400.0 765000.0 0.63 9767200.0 794432.23529412 0.668021901870083 1.2185 0.9943 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C12 mock treatment 1.01536E7 964000.0 0.83 1.024024E7 1090000.0 0.91 9706080.0 733312.23529412 0.616627337515348 1.358 0.988 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C13 mock treatment 1.001772E7 828000.0 0.71 9908920.0 760000.0 0.63 9689640.0 716872.23529412 0.602803276029879 1.1238 0.9974 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C14 mock treatment 1.075108E7 1560000.0 1.34 1.04466E7 1300000.0 1.08 9039240.0 66472.2352941204 0.0558951501084218 1.4299 0.8299 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C15 mock treatment 9966480.0 777000.0 0.67 9726000.0 577000.0 0.48 9175720.0 202952.23529412 0.170658405068078 0.7612 0.906 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C16 mock treatment 9851120.0 662000.0 0.57 1.023224E7 1080000.0 0.9 9268400.0 295632.23529412 0.248591131252581 0.9913 0.9071 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C17 compound treatment 9616520.0 427000.0 0.37 8077840.0 -1070000.0 -0.89 9226280.0 253512.23529412 0.213173280293461 -0.1775 -0.1803 3055108 HSCI1_000025 CSCC1OC([C@@H](O)[C@H]1O)n2ccc3c(N)ncnc23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C18 compound treatment 9745600.0 556000.0 0.48 8718040.0 -431000.0 -0.36 8845560.0 -127207.76470588 -0.106966420968558 0.0084 0.0138 3055110 HSCI1_000026 ClCC(=O)c1cc(Br)c(Br)s1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C19 compound treatment 3546720.0 -5640000.0 -4.86 744320.0 -8400000.0 -6.97 859960.0 -8112807.76470588 -6.82189497318011 -10.7677 -0.9882 2121 HSCI1_000027 Oc1ccc(cc1)c2oc3cc(O)cc(O)c3c(=O)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C20 compound treatment 234120.0 -8960000.0 -7.71 164840.0 -8980000.0 -7.45 163480.0 -8809287.76470588 -7.40755083348419 -13.0293 -0.9998 1916983 HSCI1_000028 CC(C)C(N1C(=O)/C(=C/c2ccccc2)/SC1=S)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C21 compound treatment 9244040.0 54600.0 0.05 9189400.0 40800.0 0.03 8805920.0 -166847.76470588 -0.140298890389725 -0.0343 -0.2261 2188 HSCI1_000029 Oc1ccc(O)c2C(=O)C(=C(Cl)C(=O)c12)Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C22 compound treatment 8983920.0 -205000.0 -0.18 8780800.0 -368000.0 -0.31 8719000.0 -253767.76470588 -0.213388149776399 -0.4015 -0.974 563 HSCI1_000030 Oc1ccc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C23 compound treatment 9053320.0 -136000.0 -0.12 8822040.0 -327000.0 -0.27 8390760.0 -582007.76470588 -0.489398486880426 -0.5066 -0.8864 1031143 HSCI1_000031 CS(=O)(=O)SCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 C24 mock treatment 8106680.0 -1080000.0 -0.93 8057120.0 -1090000.0 -0.91 7865600.0 -1107167.76470588 -0.930994845135212 -1.5983 -0.9999 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D01 mock treatment 9059040.0 -130000.0 -0.11 8902040.0 -247000.0 -0.2 8441560.0 -531207.76470588 -0.446681800538468 -0.4408 -0.8746 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D02 mock treatment 9262760.0 73400.0 0.06 8839160.0 -309000.0 -0.26 9023240.0 50472.2352941204 0.0424410756700096 -0.0873 -0.3259 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D03 compound treatment 8948960.0 -240000.0 -0.21 9161680.0 13100.0 0.01 8590440.0 -382327.76470588 -0.321491637889042 -0.2988 -0.7813 551 HSCI1_000032 CC(C)(C)c1cc(C=C(C#N)C#N)cc(Br)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D04 compound treatment 8045200.0 -1140000.0 -0.98 6548800.0 -2600000.0 -2.16 6318680.0 -2654087.76470588 -2.231768397027 -3.1022 -0.9528 3479696 HSCI1_000033 OC(=O)C(CCCCNC(=O)CNC(=O)c1cccc(c1)C(=O)NCC(=O)NCCCCC(NC(=O)OCc2ccc(cc2)C(F)(F)F)C(=O)O)NC(=O)OCc3ccc(cc3)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D05 compound treatment 8600160.0 -589000.0 -0.51 9018600.0 -130000.0 -0.11 8285360.0 -687407.76470588 -0.578027202243467 -0.6888 -0.8871 674 HSCI1_000034 CCOC(=O)c1c(C)[nH]c(/C=C/2\C(=O)Nc3ccccc23)c1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D06 compound treatment 8833080.0 -356000.0 -0.31 9355640.0 207000.0 0.17 8538280.0 -434487.76470588 -0.365351920558265 -0.2888 -0.5697 146 HSCI1_000035 CCCCCC#CCC#CCC#CCC#CCCCC(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D07 compound treatment 9041760.0 -148000.0 -0.13 9475120.0 327000.0 0.27 9135640.0 162872.23529412 0.136955948599856 0.1621 0.4926 3175981 HSCI1_000036 O=c1sn(Cc2ccccc2)c(=S)n1Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D08 compound treatment 9343800.0 154000.0 0.13 9031160.0 -117000.0 -0.1 8640920.0 -331847.76470588 -0.279044033035851 -0.1406 -0.434 1000097 HSCI1_000037 Cc1c(C)c2OC(C)(COc3ccc(CC4SC(=O)NC4=O)cc3)CCc2c(C)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D09 compound treatment 9294240.0 105000.0 0.09 9530320.0 382000.0 0.32 8877840.0 -94927.7647058796 -0.0798228257890617 0.1888 0.5574 628 HSCI1_000038 Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc34)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D10 compound treatment 9100720.0 -88700.0 -0.08 8844800.0 -304000.0 -0.25 7116840.0 -1855927.76470588 -1.56061189366681 -1.0906 -0.6891 3175982 HSCI1_000039 COc1ccc(Nc2nccc(NCCO)n2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D11 mock treatment 1.037296E7 1180000.0 1.02 1.017596E7 1030000.0 0.85 9858400.0 885632.23529412 0.744710126169033 1.5101 0.9918 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D12 mock treatment 1.036544E7 1180000.0 1.01 1.052812E7 1380000.0 1.14 1.019832E7 1225552.23529412 1.0305419376131 1.8401 0.9985 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D13 mock treatment 1.047276E7 1280000.0 1.1 9991000.0 842000.0 0.7 1.015084E7 1178072.23529412 0.990616971717112 1.6131 0.9836 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D14 mock treatment 1.03848E7 1200000.0 1.03 9970200.0 822000.0 0.68 1.005744E7 1084672.23529412 0.912078812182881 1.5141 0.9867 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D15 mock treatment 1.002368E7 834000.0 0.72 9773160.0 625000.0 0.52 9534320.0 561552.23529412 0.472197848418993 0.9863 0.9829 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D16 mock treatment 9548880.0 359000.0 0.31 1.037496E7 1230000.0 1.02 9516560.0 543792.23529412 0.457263825792355 1.03 0.8898 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D17 compound treatment 9724520.0 535000.0 0.46 1.04996E7 1350000.0 1.12 9824240.0 851472.23529412 0.715985677243023 1.3263 0.9424 584 HSCI1_000040 Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D18 compound treatment 9403960.0 215000.0 0.18 8874600.0 -274000.0 -0.23 8783200.0 -189567.76470588 -0.15940367609227 -0.1167 -0.3499 2180 HSCI1_000041 COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c4ncn(C(C)C)c4n2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D19 compound treatment 8185160.0 -1000000.0 -0.86 9439840.0 291000.0 0.24 8315760.0 -657007.76470588 -0.552464460810484 -0.6785 -0.6438 3055161 HSCI1_000042 COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D20 compound treatment 8935320.0 -254000.0 -0.22 9377320.0 229000.0 0.19 9365280.0 392512.23529412 0.330055551977167 0.1739 0.396 2067 HSCI1_000043 CC(C)C(C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1)c3ccc(Cl)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D21 compound treatment 9547880.0 358000.0 0.31 9243160.0 94500.0 0.08 9128920.0 156152.23529412 0.131305237335722 0.2992 0.8689 3055164 HSCI1_000044 N/C(=C(/C#N)\c1ccccc1C(F)(F)F)/Sc2ccc(N)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D22 compound treatment 9713120.0 524000.0 0.45 9425160.0 277000.0 0.23 9571840.0 599072.23529412 0.503747652977069 0.6835 0.9575 2407 HSCI1_000045 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ncc(C)s3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D23 compound treatment 3882160.0 -5310000.0 -4.57 3207000.0 -5940000.0 -4.93 3447320.0 -5525447.76470588 -4.64623659574447 -8.1654 -0.9995 550 HSCI1_000046 COC1=C(Br)[C@H](O)[C@](O)(CC#N)C=C1Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 D24 mock treatment 8826400.0 -363000.0 -0.31 8425640.0 -723000.0 -0.6 8092480.0 -880287.76470588 -0.740216069598527 -0.954 -0.9515 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E01 mock treatment 8447160.0 -742000.0 -0.64 8606880.0 -542000.0 -0.45 8471200.0 -501567.76470588 -0.421758127641309 -0.8718 -0.9821 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E02 mock treatment 9364560.0 175000.0 0.15 8747720.0 -401000.0 -0.33 9260000.0 287232.23529412 0.241527742172415 0.0345 0.0788 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E03 mock treatment 9706480.0 517000.0 0.45 9233400.0 84800.0 0.07 9198640.0 225872.23529412 0.189931366701104 0.4072 0.8328 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E04 mock treatment 9203040.0 13600.0 0.01 9067320.0 -81300.0 -0.07 9414680.0 441912.23529412 0.371595006805765 0.1824 0.4827 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E05 compound treatment 5908320.0 -3280000.0 -2.82 6147600.0 -3000000.0 -2.49 2495400.0 -6477367.76470588 -5.4466867544578 -6.2123 -0.9383 2294 HSCI1_000047 CC(=O)NC(C(=O)O)C(C)(C)SN=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E06 compound treatment 9372640.0 183000.0 0.16 9523960.0 375000.0 0.31 9547040.0 574272.23529412 0.48289383759753 0.5496 0.9225 3175983 HSCI1_000048 CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCC/C=C/C/C=C/C\C=C\C\C=C\CCCCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E07 compound treatment 9824600.0 635000.0 0.55 1.017256E7 1020000.0 0.85 9404280.0 431512.23529412 0.362849858420797 1.0155 0.9461 640 HSCI1_000049 O=C/1Nc2ccccc2\C1=C\c3ccc[nH]3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E08 compound treatment 1.00904E7 901000.0 0.78 1.050696E7 1360000.0 1.13 1.004688E7 1074112.23529412 0.903199123053529 1.6197 0.9882 1907779 HSCI1_000050 CC(C)n1cnc2c(NCc3ccccc3)nc(NCCO)nc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E09 mock treatment 9787160.0 598000.0 0.51 1.003276E7 884000.0 0.73 1.035664E7 1383872.23529412 1.16367000418119 1.3923 0.9481 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E10 mock treatment 1.006948E7 880000.0 0.76 1.045872E7 1310000.0 1.09 9863520.0 890752.23529412 0.749015429989325 1.4972 0.9838 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E11 compound treatment 9922960.0 734000.0 0.63 1.05222E7 1370000.0 1.14 1.007884E7 1106072.23529412 0.930073636744257 1.5594 0.9742 627 HSCI1_000051 C=CC(=O)c1ccc2ccccc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E12 compound treatment 6722800.0 -2470000.0 -2.12 6419800.0 -2730000.0 -2.26 3720600.0 -5252167.76470588 -4.41644100433638 -5.0824 -0.9416 536 HSCI1_000052 ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E13 compound treatment 1.096904E7 1780000.0 1.53 1.106376E7 1920000.0 1.59 1.06692E7 1696432.23529412 1.42649534833557 2.6251 0.999 593 HSCI1_000053 Oc1ccc2ccc(=O)oc2c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E14 compound treatment 6332600.0 -2860000.0 -2.46 6123320.0 -3030000.0 -2.51 6041480.0 -2931287.76470588 -2.4648602366725 -4.2916 -1.0 3055208 HSCI1_000054 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E15 mock treatment 1.019144E7 1000000.0 0.86 9892840.0 744000.0 0.62 9789560.0 816792.23529412 0.686823970897764 1.2509 0.99 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E16 mock treatment 1.011872E7 929000.0 0.8 1.018448E7 1040000.0 0.86 9558920.0 586152.23529412 0.492883487868051 1.2425 0.9759 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E17 mock treatment 9545560.0 356000.0 0.31 1.08902E7 1740000.0 1.44 1.073808E7 1765312.23529412 1.48441513879294 1.8681 0.8921 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E18 mock treatment 9393160.0 204000.0 0.18 1.012436E7 976000.0 0.81 9831920.0 859152.23529412 0.72244363297346 0.9857 0.8969 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E19 compound treatment 9794120.0 605000.0 0.52 1.026608E7 1120000.0 0.93 9553320.0 580552.23529412 0.488174561814607 1.1175 0.9553 1912 HSCI1_000055 [O-][N+](=O)c1cccc2cn[nH]c12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E20 compound treatment 9282480.0 93100.0 0.08 9573960.0 425000.0 0.35 9556040.0 583272.23529412 0.490461754469137 0.5331 0.8747 3175984 HSCI1_000056 CCCC(=O)OCSC(=S)OC1CC2CC1C3CCCC23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E21 compound treatment 9659040.0 470000.0 0.4 1.009452E7 946000.0 0.78 9354040.0 381272.23529412 0.320604064684183 0.8715 0.928 596 HSCI1_000057 CN(C)c1ccc(/C=C\2/C(=O)Nc3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E22 compound treatment 3481600.0 -5710000.0 -4.91 3180280.0 -5970000.0 -4.95 3066800.0 -5905967.76470588 -4.966208121076 -8.5619 -1.0 564 HSCI1_000058 Oc1ccc(/C=C(\C#N)/C(=O)NCCCCc2ccccc2)cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E23 compound treatment 9322640.0 133000.0 0.11 9179560.0 30900.0 0.03 8813240.0 -159527.76470588 -0.134143651334151 0.0036 0.0201 2175 HSCI1_000059 CCCCCCCCN1C(=O)C(=C(C)C1(C)O)C(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 E24 mock treatment 8660000.0 -529000.0 -0.46 7953720.0 -1190000.0 -0.99 7814640.0 -1158127.76470588 -0.973846072221555 -1.3976 -0.9557 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F01 mock treatment 8549040.0 -640000.0 -0.55 8529640.0 -619000.0 -0.51 7999120.0 -973647.76470588 -0.818720593946662 -1.0873 -0.9774 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F02 mock treatment 9037760.0 -152000.0 -0.13 9370680.0 222000.0 0.18 8784760.0 -188007.76470588 -0.158091903834525 -0.0603 -0.2186 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F03 mock treatment 9457120.0 268000.0 0.23 1.011552E7 967000.0 0.8 9000600.0 27832.2352941204 0.0234035603396563 0.6096 0.7302 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F04 mock treatment 9618680.0 429000.0 0.37 8903040.0 -246000.0 -0.2 9566800.0 594032.23529412 0.49950961952897 0.3841 0.5874 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F05 compound treatment 9700600.0 511000.0 0.44 9614200.0 466000.0 0.39 9775120.0 802352.23529412 0.674681668717097 0.8665 0.9701 2108 HSCI1_000060 COc1cc2C/C(=C\c3cc(C)c(O)c(C)c3)/C(=O)c2c(N)c1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F06 compound treatment 9430960.0 242000.0 0.21 1.01278E7 979000.0 0.81 7964760.0 -1008007.76470588 -0.847613218803152 0.0996 0.0836 2303 HSCI1_000061 COc1cc2CCN3Cc4c(OC)c(O)ccc4CC3c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F07 compound treatment 5415160.0 -3770000.0 -3.25 5570680.0 -3580000.0 -2.97 4319360.0 -4653407.76470588 -3.9129559036649 -5.8482 -0.9932 1967 HSCI1_000062 Brc1cccc(Nc2ncnc3cc4[nH]cnc4cc23)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F08 compound treatment 9701920.0 513000.0 0.44 9985040.0 836000.0 0.69 9535600.0 562832.23529412 0.473274174374066 0.9285 0.9787 1918768 HSCI1_000063 Clc1ccc(C(=O)n2nnc3ccccc23)c(Cl)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F09 mock treatment 9725200.0 536000.0 0.46 9973200.0 825000.0 0.68 9669160.0 696392.23529412 0.585582060748712 0.9993 0.9877 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F10 mock treatment 1.033976E7 1150000.0 0.99 1.0556E7 1410000.0 1.17 1.001024E7 1037472.23529412 0.872389292589565 1.7494 0.9929 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F11 compound treatment 9710640.0 521000.0 0.45 9773320.0 625000.0 0.52 8817680.0 -155087.76470588 -0.130410145677492 0.4829 0.6921 583 HSCI1_000064 CC(C)n1cnc2c(NCc3ccccc3)nc(NCCCO)nc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F12 compound treatment 9019960.0 -169000.0 -0.15 9670840.0 522000.0 0.43 7618000.0 -1354767.76470588 -1.13919664706964 -0.4918 -0.4006 1085933 HSCI1_000065 COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F13 compound treatment 8094120.0 -1100000.0 -0.94 7610560.0 -1540000.0 -1.28 5840560.0 -3132207.76470588 -2.63380977643286 -2.8015 -0.9112 675 HSCI1_000066 Brc1ccc2NC(=O)/C(=C\c3cc4CCCCc4[nH]3)/c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F14 compound treatment 9147840.0 -41600.0 -0.04 9155320.0 6710.0 0.01 8071960.0 -900807.76470588 -0.75747092006579 -0.4548 -0.5997 2144 HSCI1_000067 O=C(Nc1ccccc1)C2C(=O)NC(=S)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F15 mock treatment 1.005828E7 869000.0 0.75 1.025136E7 1100000.0 0.91 9715920.0 743152.23529412 0.624901593294972 1.3207 0.9881 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F16 mock treatment 9876840.0 687000.0 0.59 1.000832E7 860000.0 0.71 1.046492E7 1492152.23529412 1.25472045294314 1.4778 0.9474 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F17 mock treatment 1.00336E7 844000.0 0.73 1.015912E7 1010000.0 0.84 9399960.0 427192.23529412 0.359217258322426 1.1109 0.9527 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F18 mock treatment 9848640.0 659000.0 0.57 9830800.0 682000.0 0.57 9545480.0 572712.23529412 0.481582065339785 0.9324 0.9972 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F19 compound treatment 9337240.0 148000.0 0.13 9545560.0 397000.0 0.33 9003800.0 31032.2352941204 0.0260943752273387 0.2786 0.7872 643 HSCI1_000068 CNc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F20 compound treatment 9373880.0 184000.0 0.16 9780000.0 631000.0 0.52 9439480.0 466712.23529412 0.392448822185304 0.6207 0.9216 122 HSCI1_000069 C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F21 compound treatment 9066040.0 -123000.0 -0.11 8615680.0 -533000.0 -0.44 8477960.0 -494807.76470588 -0.41607378119108 -0.5568 -0.9034 590 HSCI1_000070 CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F22 compound treatment 9221320.0 31900.0 0.03 9341720.0 193000.0 0.16 9290160.0 317392.23529412 0.266888672488822 0.2624 0.8399 2060831 HSCI1_000071 O=C1CCCC(=O)C1CC2C(=O)CCCC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F23 compound treatment 7764680.0 -1420000.0 -1.23 7571040.0 -1580000.0 -1.31 6332960.0 -2639807.76470588 -2.21976063559072 -2.7451 -0.9619 3176054 HSCI1_000072 N/C(=C(/C#N)\C(=C(/N)\Sc1ccccc1)\[N+]#[C-])/Sc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 F24 mock treatment 8293040.0 -896000.0 -0.77 8439520.0 -709000.0 -0.59 7711560.0 -1261207.76470588 -1.06052394679103 -1.3973 -0.9722 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G01 mock treatment 8094680.0 -1090000.0 -0.94 8521440.0 -627000.0 -0.52 8232960.0 -739807.76470588 -0.622089296029267 -1.2035 -0.9681 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G02 compound treatment 7707440.0 -1480000.0 -1.28 4031200.0 -5120000.0 -4.25 3749680.0 -5223087.76470588 -4.39198822404457 -5.7231 -0.9172 305 HSCI1_000073 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G03 mock treatment 9904760.0 715000.0 0.62 1.010996E7 961000.0 0.8 9512880.0 540112.23529412 0.45416938867152 1.0781 0.9755 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G04 mock treatment 9071960.0 -117000.0 -0.1 9796400.0 648000.0 0.54 9878280.0 905512.23529412 0.76142681365876 0.6915 0.7377 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G05 mock treatment 1.010004E7 911000.0 0.78 9869680.0 721000.0 0.6 9126840.0 154072.23529412 0.129556207658729 0.8726 0.8776 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G06 mock treatment 9853800.0 664000.0 0.57 9415920.0 267000.0 0.22 9746880.0 774112.23529412 0.650935227333299 0.834 0.9325 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G07 compound treatment 9180200.0 -9190.0 -0.01 9743600.0 595000.0 0.49 8895880.0 -76887.7647058796 -0.0646533568597519 0.2431 0.4882 2073 HSCI1_000074 CC(=CCC/C(=C/CC/C(=C/CSc1nc[nH]n1)/C)/C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G08 compound treatment 3676040.0 -5510000.0 -4.75 3394880.0 -5750000.0 -4.77 3270200.0 -5702567.76470588 -4.79517319977769 -8.2638 -1.0 3176055 HSCI1_000075 CCOc1cc(/C=C(/C#N)\C(=O)N)cc(CSc2ccccc2)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G09 compound treatment 8109720.0 -1080000.0 -0.93 8326280.0 -822000.0 -0.68 5369840.0 -3602927.76470588 -3.02962864641095 -2.6795 -0.8266 2335 HSCI1_000076 COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G10 compound treatment 8712760.0 -477000.0 -0.41 8380480.0 -768000.0 -0.64 7421320.0 -1551447.76470588 -1.30458085710382 -1.3579 -0.9001 3055275 HSCI1_000077 CC(C)(C)OC(=O)NC(CC(=O)CCl)C(=O)Cc1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G11 compound treatment 9291880.0 102000.0 0.09 9685760.0 537000.0 0.45 8753040.0 -219727.76470588 -0.184764606408677 0.2015 0.4109 2134 HSCI1_000078 COc1cc(O)c(cc1/C=C/C(=O)c2ccc(O)cc2)C(C)(C)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G12 compound treatment 9674040.0 485000.0 0.42 9892240.0 744000.0 0.62 9237080.0 264312.23529412 0.222254780539389 0.7253 0.9333 3055277 HSCI1_000079 COc1cc(cc(CN(C)CCc2ccc(cc2)[N+](=O)[O-])c1O)N(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G13 compound treatment 5904680.0 -3280000.0 -2.83 6870720.0 -2280000.0 -1.89 4324800.0 -4647967.76470588 -3.90838151835584 -4.9796 -0.9612 1002387 HSCI1_000080 Oc1ccc(C=C(C#N)C#N)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G14 compound treatment 6951600.0 -2240000.0 -1.93 8226720.0 -922000.0 -0.76 6198080.0 -2774687.76470588 -2.33317848310654 -2.9005 -0.9295 3176058 HSCI1_000081 C[C@@H]1[C@@H](O)[C@@]2(O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@]13O)C2(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G15 compound treatment 545520.0 -8640000.0 -7.44 668200.0 -8480000.0 -7.04 312520.0 -8660247.76470588 -7.28222613009038 -12.5612 -0.9997 672 HSCI1_000082 Oc1ccc(CC(C#N)C#N)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G16 compound treatment 9445560.0 256000.0 0.22 9349520.0 201000.0 0.17 9357320.0 384552.23529412 0.323362149944057 0.4102 0.9643 3176059 HSCI1_000083 OCc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G17 mock treatment 9486880.0 297000.0 0.26 1.015504E7 1010000.0 0.83 9630400.0 657632.23529412 0.552989565421658 0.9491 0.9182 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G18 mock treatment 9838120.0 649000.0 0.56 1.04268E7 1280000.0 1.06 9879040.0 906272.23529412 0.762065882194584 1.3745 0.9679 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G19 mock treatment 9304440.0 115000.0 0.1 9812160.0 664000.0 0.55 9699480.0 726712.23529412 0.611077531809503 0.7278 0.8785 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G20 mock treatment 9677400.0 488000.0 0.42 9990640.0 842000.0 0.7 9700280.0 727512.23529412 0.611750235531424 0.999 0.9802 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G21 compound treatment 9340360.0 151000.0 0.13 9901320.0 753000.0 0.62 9418600.0 445832.23529412 0.374891255043176 0.652 0.8813 3415700 HSCI1_000084 CCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G22 compound treatment 8593080.0 -596000.0 -0.51 9717520.0 569000.0 0.47 8745760.0 -227007.76470588 -0.190886210278155 -0.134 -0.1854 3176060 HSCI1_000085 CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]4CCCC[C@@H]4N)nc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G23 compound treatment 7484440.0 -1700000.0 -1.47 8394640.0 -754000.0 -0.63 6993400.0 -1979367.76470588 -1.66441007795916 -2.1692 -0.941 3055326 HSCI1_000086 Cc1ccc(cc1)c2cn3c4CCCCc4sc3n2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 G24 mock treatment 8514240.0 -675000.0 -0.58 9060720.0 -87900.0 -0.07 8919200.0 -53567.7647058796 -0.045044043365766 -0.4036 -0.6871 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H01 mock treatment 9284120.0 94700.0 0.08 8815000.0 -334000.0 -0.28 8790840.0 -181927.76470588 -0.152979355547928 -0.201 -0.6156 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H02 compound treatment 9338280.0 149000.0 0.13 8260000.0 -889000.0 -0.74 7808960.0 -1163807.76470588 -0.978622268647192 -0.9166 -0.7441 1886 HSCI1_000087 NCCOB(c1ccccc1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H03 mock treatment 9756960.0 568000.0 0.49 9195640.0 47000.0 0.04 9223000.0 250232.23529412 0.210415195033586 0.426 0.7989 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H04 mock treatment 9514120.0 325000.0 0.28 9412040.0 263000.0 0.22 9084720.0 111952.23529412 0.0941383566996086 0.3419 0.9314 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H05 mock treatment 9727320.0 538000.0 0.46 1.033804E7 1190000.0 0.99 9893160.0 920392.23529412 0.773939102886483 1.2838 0.9604 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H06 mock treatment 1.022208E7 1030000.0 0.89 1.024812E7 1100000.0 0.91 9552800.0 580032.23529412 0.487737304395359 1.3213 0.9689 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H07 compound treatment 1.008588E7 896000.0 0.77 1.002836E7 880000.0 0.73 9412040.0 439272.23529412 0.369375084523427 1.0801 0.9605 2278 HSCI1_000088 Oc1cc(ccc1NC(=O)Nc2ccccc2Br)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H08 compound treatment 1.014948E7 960000.0 0.83 1.016716E7 1020000.0 0.84 8574000.0 -398767.76470588 -0.33531569937451 0.7713 0.6279 1891 HSCI1_000089 Clc1oc(=O)c2ccccc2c1Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H09 compound treatment 9718360.0 529000.0 0.46 1.031376E7 1170000.0 0.97 9582240.0 609472.23529412 0.512492801362037 1.1168 0.9424 1966 HSCI1_000090 Cn1cnc2cc3c(Nc4cccc(Br)c4)ncnc3cc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H10 compound treatment 5138000.0 -4050000.0 -3.49 4722680.0 -4430000.0 -3.67 4089680.0 -4883087.76470588 -4.10608914222831 -6.5036 -0.9976 3176061 HSCI1_000091 CC1(CCC2(C)O1)C(C2C(=O)O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H11 compound treatment 3311040.0 -5880000.0 -5.06 5910600.0 -3240000.0 -2.69 4170800.0 -4801967.76470588 -4.03787698482556 -6.803 -0.9707 291 HSCI1_000092 CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H12 compound treatment 8764840.0 -425000.0 -0.37 1.07886E7 1640000.0 1.36 8750080.0 -222687.76470588 -0.187253610179783 0.4664 0.3282 3055333 HSCI1_000093 O=C/1Nc2ccccc2\C1=C/c3c[nH]cn3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H13 compound treatment 1.0002E7 813000.0 0.7 1.043204E7 1280000.0 1.06 1.00284E7 1055632.23529412 0.887659667077163 1.531 0.9861 3176062 HSCI1_000094 CC[C@@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H14 compound treatment 9260200.0 70800.0 0.06 9787920.0 639000.0 0.53 9384080.0 411312.23529412 0.345864089442302 0.5411 0.8506 1040138 HSCI1_000095 COc1cc(C=O)c(cc1OC)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H15 compound treatment 9628640.0 439000.0 0.38 1.009048E7 942000.0 0.78 9585440.0 612672.23529412 0.51518361624972 0.9668 0.9578 3176063 HSCI1_000096 CC(C)n1cnc2c(NCc3ccccc3O)nc(NCCCO)nc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H16 compound treatment 1019400.0 -8170000.0 -7.03 2936600.0 -6210000.0 -5.15 1647200.0 -7325567.76470588 -6.15992087562413 -10.5913 -0.9922 2109 HSCI1_000097 OCc1c[nH]c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H17 mock treatment 9832640.0 643000.0 0.55 1.004144E7 893000.0 0.74 1.00044E7 1031632.23529412 0.867478555419544 1.2481 0.9844 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H18 mock treatment 1.018872E7 999000.0 0.86 1.025172E7 1100000.0 0.92 9514720.0 541952.23529412 0.455716607231938 1.288 0.9641 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H19 mock treatment 9321680.0 132000.0 0.11 1.02796E7 1130000.0 0.94 9424640.0 451872.23529412 0.379970168143677 0.8268 0.8117 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H20 mock treatment 9744480.0 555000.0 0.48 1.075076E7 1600000.0 1.33 1.0016E7 1043232.23529412 0.877232759387393 1.5496 0.9321 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H21 compound treatment 2187400.0 -7000000.0 -6.03 5968960.0 -3180000.0 -2.64 2559240.0 -6413527.76470588 -5.39300499744854 -8.1158 -0.9541 3176064 HSCI1_000098 O/N=C\1/C(=C\2/C(=O)Nc3ccc(cc23)S(=O)(=O)O)/Nc4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H22 compound treatment 8912640.0 -277000.0 -0.24 9200840.0 52200.0 0.04 8770000.0 -202767.76470588 -0.17050328750396 -0.2109 -0.7124 2069332 HSCI1_000099 CC(=O)/C(=N/O)/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H23 compound treatment 7705280.0 -1480000.0 -1.28 9585080.0 436000.0 0.36 7585600.0 -1387167.76470588 -1.16644114780743 -1.2018 -0.6801 642 HSCI1_000100 COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 H24 mock treatment 8523680.0 -666000.0 -0.57 8142400.0 -1010000.0 -0.83 8279560.0 -693207.76470588 -0.582904304227391 -1.1493 -0.9837 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I01 mock treatment 8175600.0 -1010000.0 -0.87 8778000.0 -371000.0 -0.31 7506520.0 -1466247.76470588 -1.23293791071928 -1.3931 -0.9038 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I02 compound treatment 8481600.0 -708000.0 -0.61 8826080.0 -323000.0 -0.27 8454920.0 -517847.76470588 -0.435447648382393 -0.7576 -0.9527 666 HSCI1_000101 CC(C)c1cc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc(C(C)C)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I03 compound treatment 8473240.0 -716000.0 -0.62 9565560.0 417000.0 0.35 8638880.0 -333887.76470588 -0.280759427526749 -0.3182 -0.4185 3176066 HSCI1_000102 CCCCC/C=C/C/C=C/C\C=C\C\C=C\CCCC(=O)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I04 compound treatment 8821920.0 -367000.0 -0.32 7763720.0 -1380000.0 -1.15 7496480.0 -1476287.76470588 -1.24138034242938 -1.5626 -0.9081 2104844 HSCI1_000103 Oc1ccc(O)c(CNc2ccc(cc2)C(=O)OC3(CC4CC5CC(C4)C3)C5)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I05 mock treatment 8968360.0 -221000.0 -0.19 9131640.0 -17000.0 -0.01 9114240.0 141472.23529412 0.118961124038479 -0.0493 -0.2192 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I06 mock treatment 1.01096E7 920000.0 0.79 1.027456E7 1130000.0 0.93 9279960.0 307192.23529412 0.258311700034334 1.1457 0.9154 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I07 mock treatment 9804680.0 615000.0 0.53 9626320.0 478000.0 0.4 9445160.0 472392.23529412 0.39722501861094 0.7639 0.9901 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I08 mock treatment 9596720.0 407000.0 0.35 1.011836E7 970000.0 0.8 9967520.0 994752.23529412 0.836466913839004 1.1498 0.9484 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I09 compound treatment 1.062472E7 1440000.0 1.24 1.015736E7 1010000.0 0.84 1.030392E7 1331152.23529412 1.11933882890662 1.8426 0.9879 626 HSCI1_000104 CC(C)N(CCC(=O)c1ccc2ccccc2c1)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I10 compound treatment 9866040.0 677000.0 0.58 9939960.0 791000.0 0.66 8764560.0 -208207.76470588 -0.17507767281302 0.6142 0.6863 3055340 HSCI1_000105 Cc1ccc(N/N=C/2\C(=O)Nc3ccc(Br)cc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I11 compound treatment 9324080.0 135000.0 0.12 9681520.0 533000.0 0.44 8519680.0 -453087.76470588 -0.38099228209292 0.1022 0.1718 568 HSCI1_000106 COc1ccc(C=C(C#N)C#N)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I12 compound treatment 8700880.0 -489000.0 -0.42 9176440.0 27800.0 0.02 7685440.0 -1287327.76470588 -1.08248772331173 -0.8544 -0.7356 3176067 HSCI1_000107 Ic1cccc(CSc2nnc(o2)c3ccncc3)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I13 compound treatment 9258880.0 69500.0 0.06 9816920.0 668000.0 0.55 8718120.0 -254647.76470588 -0.214128123870512 0.231 0.3867 558 HSCI1_000108 Oc1ccc(C=C(C#N)C#N)cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I14 compound treatment 8456320.0 -733000.0 -0.63 9269400.0 121000.0 0.1 7492880.0 -1479887.76470588 -1.24440750917803 -1.0249 -0.7327 3176068 HSCI1_000109 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)CCCCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I15 compound treatment 9175480.0 -13900.0 -0.01 9399960.0 251000.0 0.21 9391200.0 418432.23529412 0.351851152567395 0.3166 0.7738 1975 HSCI1_000110 C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)CC[C@@H]1c5ccc(=O)oc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I16 compound treatment 7672280.0 -1520000.0 -1.31 8243600.0 -905000.0 -0.75 8114720.0 -858047.76470588 -0.721514906129134 -1.6039 -0.9604 1001980 HSCI1_000111 CCCCCCCC/C=C/CCCCCCCC(=O)OCC(CO)OC(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I17 compound treatment 849640.0 -8340000.0 -7.18 1877560.0 -7270000.0 -6.03 662720.0 -8310047.76470588 -6.98775007581964 -11.6608 -0.9972 130 HSCI1_000112 C/C(=C\C=C\C(=C\C(=O)Nc1ccc(O)cc1)\C)/C=C/C2=C(C)CCCC2(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I18 compound treatment 3478200.0 -5710000.0 -4.92 3919560.0 -5230000.0 -4.34 3665840.0 -5306927.76470588 -4.46248757410185 -7.9187 -0.9985 1922639 HSCI1_000113 CC(C)C(N1C(=O)/C(=C/c2ccc(Br)cc2)/SC1=S)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I19 mock treatment 9841880.0 652000.0 0.56 9692400.0 544000.0 0.45 9770560.0 797792.23529412 0.670847257502149 0.972 0.9875 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I20 mock treatment 9516640.0 327000.0 0.28 1.010132E7 953000.0 0.79 9901720.0 928952.23529412 0.781137032711034 1.0699 0.9333 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I21 mock treatment 9382840.0 193000.0 0.17 1.03818E7 1230000.0 1.02 8970720.0 -2047.76470587961 -0.0017219236740786 0.6858 0.6616 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I22 mock treatment 9027160.0 -162000.0 -0.14 9286080.0 137000.0 0.11 9364040.0 391272.23529412 0.32901286120819 0.1752 0.467 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I23 compound treatment 9073560.0 -116000.0 -0.1 9282280.0 134000.0 0.11 8959240.0 -13527.7647058796 -0.0113752220836394 -1.0E-4 -7.0E-4 565 HSCI1_000114 Oc1cc(C=C(C#N)C#N)cc(O)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 I24 mock treatment 8573440.0 -616000.0 -0.53 8584840.0 -564000.0 -0.47 8010440.0 -962327.76470588 -0.809201836281485 -1.0433 -0.9709 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J01 mock treatment 8850920.0 -338000.0 -0.29 8243800.0 -905000.0 -0.75 7985160.0 -987607.76470588 -0.830459273894177 -1.081 -0.9346 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J02 compound treatment 7403440.0 -1790000.0 -1.54 6774400.0 -2370000.0 -1.97 6556800.0 -2415967.76470588 -2.03153813419733 -3.1975 -0.993 3176070 HSCI1_000115 OC(=O)c1c(Br)c(Br)c(Br)c(Br)c1c2c3ccc(O)cc3oc4cc(=O)ccc24 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J03 compound treatment 4629120.0 -4560000.0 -3.92 2426280.0 -6720000.0 -5.58 2183840.0 -6788927.76470588 -5.70867121895978 -8.7815 -0.9874 294 HSCI1_000116 [O-][N+](=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J04 compound treatment 8995120.0 -194000.0 -0.17 8710080.0 -439000.0 -0.36 7938040.0 -1034727.76470588 -0.870081523115301 -0.8089 -0.8446 3055387 HSCI1_000117 C[C@@]12CCC3C(CCC4=C[C@H](O)CCC34)C2CC[C@@H]1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J05 mock treatment 9492640.0 303000.0 0.26 9499040.0 350000.0 0.29 9060480.0 87712.2352941204 0.0737554339254141 0.3611 0.9083 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J06 mock treatment 9564040.0 375000.0 0.32 1.006604E7 917000.0 0.76 9587600.0 614832.23529412 0.516999916298905 0.9241 0.9478 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J07 mock treatment 9823400.0 634000.0 0.55 9252560.0 104000.0 0.09 9709760.0 736992.23529412 0.619721774636183 0.7226 0.8704 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J08 mock treatment 9732440.0 543000.0 0.47 9651560.0 503000.0 0.42 9732600.0 759832.23529412 0.638927465897016 0.8796 0.983 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J09 compound treatment 7867200.0 -1320000.0 -1.14 7585040.0 -1560000.0 -1.3 6329120.0 -2643647.76470588 -2.22298961345594 -2.6893 -0.9557 633 HSCI1_000118 OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3ccccc3O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J10 compound treatment 9476680.0 287000.0 0.25 9568360.0 420000.0 0.35 9003240.0 30472.2352941204 0.0256234826219943 0.3586 0.8381 2251 HSCI1_000119 O=C(NC1=CC(=O)c2ccccc2C1=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J11 compound treatment 1.001196E7 823000.0 0.71 1.036388E7 1220000.0 1.01 9447080.0 474312.23529412 0.39883950754355 1.2211 0.943 645 HSCI1_000120 Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J12 compound treatment 1.000216E7 813000.0 0.7 1.034128E7 1190000.0 0.99 1.094752E7 1974752.23529412 1.66052897319175 1.9338 0.9407 3176071 HSCI1_000121 Nc1nc(Cl)nc2n(cnc12)C3C[C@@H](O)C(CO)O3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J13 compound treatment 1.036548E7 1180000.0 1.01 9875200.0 727000.0 0.6 9390120.0 417352.23529412 0.350943002542802 1.135 0.9233 646 HSCI1_000122 CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J14 compound treatment 7705840.0 -1480000.0 -1.28 8863320.0 -285000.0 -0.24 7443120.0 -1529647.76470588 -1.28624968068149 -1.6164 -0.8844 854065 HSCI1_000123 CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J15 compound treatment 2461320.0 -6730000.0 -5.79 4547840.0 -4600000.0 -3.82 1505440.0 -7467327.76470588 -6.27912397514846 -9.1719 -0.9804 670 HSCI1_000124 CN(C)S(=O)(=O)c1ccc2NC(=O)/C(=C\c3cc4CCCCc4[nH]3)/c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J16 compound treatment 9971560.0 782000.0 0.67 9395000.0 246000.0 0.2 9396480.0 423712.23529412 0.356290997132071 0.7124 0.9033 3176072 HSCI1_000125 CN(C)c1ccc(/C=C/2\C(=O)Nc3ccccc23)c4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J17 compound treatment 9969600.0 780000.0 0.67 9682240.0 534000.0 0.44 9957360.0 984592.23529412 0.827923576570612 1.1213 0.9714 1996 HSCI1_000126 CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J18 compound treatment 8609600.0 -580000.0 -0.5 9710080.0 561000.0 0.47 9153200.0 180432.23529412 0.151721795296013 0.0684 0.0978 2268 HSCI1_000127 CC(=CC1C(C(=O)OCc2coc(Cc3ccccc3)c2)C1(C)C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J19 mock treatment 1.022036E7 1030000.0 0.89 1.051136E7 1360000.0 1.13 9800080.0 827312.23529412 0.69567002484102 1.5666 0.9812 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J20 mock treatment 9731160.0 542000.0 0.47 1.023092E7 1080000.0 0.9 9966960.0 994192.23529412 0.83599602123366 1.2702 0.9679 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J21 mock treatment 9317120.0 128000.0 0.11 1.023796E7 1090000.0 0.9 9498400.0 525632.23529412 0.441993451304757 0.8404 0.8304 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J22 mock treatment 9482360.0 293000.0 0.25 9524080.0 375000.0 0.31 9451480.0 478712.23529412 0.402539378014113 0.5578 0.9821 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J23 compound treatment 8855280.0 -334000.0 -0.29 8409880.0 -739000.0 -0.61 8566800.0 -405967.76470588 -0.341370032871796 -0.7169 -0.9456 654 HSCI1_000128 CC(C)C(CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 J24 mock treatment 8246080.0 -943000.0 -0.81 8354320.0 -794000.0 -0.66 8560320.0 -412447.76470588 -0.346818933019353 -1.0494 -0.9526 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K01 mock treatment 8079440.0 -1110000.0 -0.96 8289400.0 -859000.0 -0.71 7532040.0 -1440727.76470588 -1.21147866199001 -1.6625 -0.9782 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K02 compound treatment 8566040.0 -623000.0 -0.54 8902240.0 -246000.0 -0.2 8424480.0 -548287.76470588 -0.461044025001473 -0.6939 -0.9424 3055432 HSCI1_000129 CCOC(=O)c1cc(OC)c(OC)cc1NC(=O)c2cc(OC)c(OC)c(OC)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K03 compound treatment 9033560.0 -156000.0 -0.13 8781080.0 -368000.0 -0.3 9284280.0 311512.23529412 0.261944300132705 -0.1022 -0.2412 570 HSCI1_000130 NC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K04 compound treatment 8434800.0 -755000.0 -0.65 6146880.0 -3000000.0 -2.49 5998120.0 -2974647.76470588 -2.50132077840059 -3.2568 -0.9075 1005921 HSCI1_000131 OCC1OC(Oc2cc(O)c3c(=O)c(coc3c2)c4ccc(O)cc4)C(O)C(O)C1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K05 compound treatment 8710840.0 -479000.0 -0.41 7325880.0 -1820000.0 -1.51 6703840.0 -2268927.76470588 -1.90789519010833 -2.2123 -0.896 559 HSCI1_000132 OC(=O)/C(=C/c1ccc(O)c(O)c1)/C#N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K06 compound treatment 8030160.0 -1160000.0 -1.0 8479040.0 -670000.0 -0.56 7994040.0 -978727.76470588 -0.822992262580858 -1.3719 -0.9746 620 HSCI1_000133 COc1cc(/C=C(\C#N)/C(=O)c2ccc(O)c(O)c2)cc(I)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K07 mock treatment 9981360.0 792000.0 0.68 1.03576E7 1210000.0 1.0 8952920.0 -19847.7647058796 -0.0166895814868122 0.9629 0.794 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K08 mock treatment 1.002596E7 837000.0 0.72 1.009732E7 949000.0 0.79 9185240.0 212472.23529412 0.178663579358934 0.9732 0.8999 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K09 mock treatment 9322520.0 133000.0 0.11 9326200.0 178000.0 0.15 9858120.0 885352.23529412 0.74447467986636 0.581 0.757 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K10 mock treatment 1.032868E7 1140000.0 0.98 1.03972E7 1250000.0 1.04 9445320.0 472552.23529412 0.397359559355325 1.3935 0.9412 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K11 compound treatment 9214520.0 25100.0 0.02 9193240.0 44600.0 0.04 8619400.0 -353367.76470588 -0.297139763155515 -0.1377 -0.4586 553 HSCI1_000134 Oc1cc(C=C(C#N)C#N)ccc1[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K12 compound treatment 9298240.0 109000.0 0.09 9960120.0 812000.0 0.67 7066600.0 -1906167.76470588 -1.60285768740342 -0.4827 -0.2772 3176129 HSCI1_000135 Oc1cc(/C=C(\C#N)/C(=O)NCCCc2ccccc2)cc(I)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K13 compound treatment 9216360.0 27000.0 0.02 9519120.0 371000.0 0.31 8866080.0 -106687.76470588 -0.0897115705012947 0.1391 0.4332 1000035 HSCI1_000136 O=C1c2ccccc2-c3n[nH]c4cccc1c34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K14 compound treatment 9517920.0 329000.0 0.28 1.001704E7 868000.0 0.72 9482760.0 509992.23529412 0.428842093541209 0.8268 0.9344 1 HSCI1_000137 Oc1ccc(/C=C(\C#N)/C(=O)NCCCNC(=O)\C(=C\c2ccc(O)c(O)c2)\C#N)cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K15 mock treatment 9295760.0 106000.0 0.09 1.05814E7 1430000.0 1.19 9436880.0 464112.23529412 0.390262535089062 0.9644 0.7688 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K16 mock treatment 9743360.0 554000.0 0.48 9558640.0 410000.0 0.34 9401520.0 428752.23529412 0.360529030580171 0.6798 0.9884 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K17 compound treatment 7741520.0 -1450000.0 -1.25 8907560.0 -241000.0 -0.2 7922880.0 -1049887.76470588 -0.882829258645696 -1.3446 -0.873 554 HSCI1_000138 Oc1cc(C=C(C#N)C#N)cc([N+](=O)[O-])c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K18 compound treatment 8821120.0 -368000.0 -0.32 9219240.0 70600.0 0.06 8292800.0 -679967.76470588 -0.571771057629605 -0.4793 -0.7302 3176130 HSCI1_000139 CN(C)c1ccc2c(c3ccccc3C(=O)O)c4ccc(=[N+](C)C)cc4oc2c1.CC(=O)NCCSS(=O)(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K19 compound treatment 9828800.0 639000.0 0.55 9885320.0 737000.0 0.61 9395240.0 422472.23529412 0.355248306363094 0.8757 0.9775 555 HSCI1_000140 Cc1cc2ncc(nc2cc1C)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K20 compound treatment 3675840.0 -5510000.0 -4.75 3753200.0 -5400000.0 -4.48 3151440.0 -5821327.76470588 -4.8950360672968 -8.1499 -0.9993 2311 HSCI1_000141 COC(=O)c1c(c2cc(OC)c(OC)c(OC)c2)c3ccnc(OCc4ncccn4)c3c(=O)n1Cc5ccnc(C)c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K21 mock treatment 9202640.0 13200.0 0.01 9872200.0 724000.0 0.6 9303600.0 330832.23529412 0.278190095017088 0.5138 0.7764 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K22 mock treatment 9404600.0 215000.0 0.19 9336880.0 188000.0 0.16 8980840.0 8072.23529412039 0.00678777840821714 0.201 0.8294 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K23 mock treatment 8962800.0 -227000.0 -0.2 9385160.0 237000.0 0.2 8924200.0 -48567.7647058796 -0.0408396451037622 -0.0229 -0.0818 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 K24 mock treatment 8100720.0 -1090000.0 -0.94 8261640.0 -887000.0 -0.74 8707320.0 -265447.76470588 -0.22320962411644 -1.0946 -0.9031 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L01 mock treatment 8731520.0 -458000.0 -0.39 8025320.0 -1120000.0 -0.93 8479920.0 -492847.76470588 -0.414425657072374 -1.0048 -0.919 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L02 compound treatment 8716960.0 -472000.0 -0.41 7345280.0 -1800000.0 -1.5 6747680.0 -2225087.76470588 -1.87103102614708 -2.1787 -0.8966 1995 HSCI1_000142 CN(C1CCCCC1)C(=O)CCCOc2ccc3[nH]c(=O)ccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L03 compound treatment 5792480.0 -3400000.0 -2.92 5691640.0 -3460000.0 -2.87 5640040.0 -3332727.76470588 -2.80242296433226 -4.9616 -0.9999 3176131 HSCI1_000143 Nc1ncnc2n(cc(I)c12)C3OC(CO)[C@H](O)[C@@H]3O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L04 compound treatment 9020920.0 -168000.0 -0.14 7522480.0 -1630000.0 -1.35 7446320.0 -1526447.76470588 -1.28355886579381 -1.6036 -0.8586 3055484 HSCI1_000144 COc1cc(SC)ccc1c2nc3ccncc3[nH]2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L05 compound treatment 9254880.0 65500.0 0.06 9711800.0 563000.0 0.47 9488280.0 515512.23529412 0.433483749222461 0.5526 0.8636 1907775 HSCI1_000145 CS(=O)(=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L06 compound treatment 1.013176E7 942000.0 0.81 1.006684E7 918000.0 0.76 9884880.0 912112.23529412 0.766976619364605 1.3509 0.9996 3176132 HSCI1_000146 COc1ccc(cc1)C(=C2C(=O)Nc3ccccc23)c4ccc(OC)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L07 mock treatment 1.016152E7 972000.0 0.84 9583880.0 435000.0 0.36 9748840.0 776072.23529412 0.652583351452005 1.0683 0.9531 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L08 mock treatment 1.025804E7 1070000.0 0.92 9251160.0 103000.0 0.09 9854520.0 881752.23529412 0.741447513117718 1.0082 0.8512 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L09 mock treatment 1.050632E7 1320000.0 1.13 1.035208E7 1200000.0 1.0 9644200.0 671432.23529412 0.564593704624789 1.5567 0.9654 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L10 mock treatment 9763480.0 574000.0 0.49 9973640.0 825000.0 0.68 9618320.0 645552.23529412 0.542831739220657 0.9938 0.9902 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L11 compound treatment 1033920.0 -8160000.0 -7.02 1975360.0 -7170000.0 -5.95 664120.0 -8308647.76470588 -6.98657284430627 -11.5217 -0.9972 3055486 HSCI1_000147 O=C1NC(=O)c2c1c3c4ccccc4n5C6CCC(O6)n7c8ccccc8c2c7c53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L12 compound treatment 8623440.0 -566000.0 -0.49 9669920.0 521000.0 0.43 8951600.0 -21167.7647058796 -0.0177995426279812 -0.0418 -0.0642 3176133 HSCI1_000148 OC(=O)c1ccc(Cl)cc1NC(=O)Nc2cccc(c2)C(F)(F)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L13 compound treatment 1250200.0 -7940000.0 -6.83 1272720.0 -7880000.0 -6.53 1129280.0 -7843487.76470588 -6.59542926519554 -11.525 -0.9998 3176134 HSCI1_000149 O/N=C\1/C(=C\2/C(=O)Nc3ccc(I)cc23)/Nc4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L14 compound treatment 776720.0 -8410000.0 -7.24 1938800.0 -7210000.0 -5.98 632600.0 -8340167.76470588 -7.01307737094995 -11.6823 -0.9967 3055490 HSCI1_000150 COc1cc(ccc1c2nc3ccncc3[nH]2)S(=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L15 mock treatment 1.011284E7 923000.0 0.79 1.042832E7 1280000.0 1.06 1.011872E7 1145952.23529412 0.963607917282 1.6281 0.9932 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L16 mock treatment 1.008276E7 893000.0 0.77 9812520.0 664000.0 0.55 9666280.0 693512.23529412 0.583160327349798 1.0986 0.9887 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L17 compound treatment 9683040.0 494000.0 0.42 1.001972E7 871000.0 0.72 9053520.0 80752.2352941204 0.0679029115447048 0.7017 0.8344 3176135 HSCI1_000151 C[S+](O)c1ccc(CSc2nc(c([nH]2)c3ccc(F)cc3)c4ccncc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L18 compound treatment 8892360.0 -297000.0 -0.26 9653920.0 505000.0 0.42 7937240.0 -1035527.76470588 -0.870754226837221 -0.4083 -0.4085 2109556 HSCI1_000152 Nc1n[nH]c2nc3ccccc3nc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L19 compound treatment 9301320.0 112000.0 0.1 9999440.0 851000.0 0.71 9214680.0 241912.23529412 0.203419076325612 0.5806 0.7837 3176136 HSCI1_000153 C[C@@H]1C2NCC(C)C[C@H]2O[C@@]31CCC4C5CC=C6CC(O)CCC6(C)C5C(=O)C4=C3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L20 compound treatment 9825680.0 636000.0 0.55 9990240.0 842000.0 0.7 9554720.0 581952.23529412 0.489351793327968 1.0018 0.9886 3055494 HSCI1_000154 OB(O)c1ccc(cc1)C(=O)/C=C/c2ccc(I)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L21 mock treatment 9656320.0 467000.0 0.4 9762080.0 613000.0 0.51 8915240.0 -57527.7647058796 -0.0483739267892731 0.4979 0.7657 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L22 mock treatment 9463800.0 274000.0 0.24 9137000.0 -11600.0 -0.01 8921280.0 -51487.7647058796 -0.0432950136887724 0.1058 0.4403 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L23 mock treatment 8995880.0 -194000.0 -0.17 9445240.0 297000.0 0.25 8482600.0 -490167.76470588 -0.41217209960394 -0.1921 -0.378 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 L24 mock treatment 8905440.0 -284000.0 -0.24 8184080.0 -965000.0 -0.8 7501840.0 -1470927.76470588 -1.23687322749251 -1.3172 -0.8821 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M01 mock treatment 7759160.0 -1430000.0 -1.23 8105840.0 -1040000.0 -0.87 8101680.0 -871087.76470588 -0.73247997679644 -1.633 -0.9759 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M02 compound treatment 1996360.0 -7190000.0 -6.19 1840120.0 -7310000.0 -6.06 1622840.0 -7349927.76470588 -6.18040470395661 -10.6428 -1.0 2095175 HSCI1_000155 Oc1ccc(/C=C(\C#N)/C(=O)NC2CCC(CC3CCC(CC3)NC(=O)\C(=C\c4ccc(O)c(O)c4)\C#N)CC2)cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M03 compound treatment 8480400.0 -709000.0 -0.61 8855120.0 -293000.0 -0.24 8588800.0 -383967.76470588 -0.322870680518979 -0.6793 -0.9279 552 HSCI1_000156 NC(=C(C#N)C#N)/C(=C/c1ccc(O)cc1)/C#N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M04 compound treatment 8580160.0 -609000.0 -0.52 8452360.0 -696000.0 -0.58 7873560.0 -1099207.76470588 -0.924301443102102 -1.1698 -0.9672 613 HSCI1_000157 Oc1cc(/C=C/c2ccc(O)c(O)c2)oc(=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M05 compound treatment 8465280.0 -724000.0 -0.62 8024160.0 -1120000.0 -0.93 7990320.0 -982447.76470588 -0.826120334887789 -1.3753 -0.9872 657 HSCI1_000158 COc1ccc(/C=C(\C#N)/c2cccnc2)cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M06 compound treatment 8271680.0 -918000.0 -0.79 7281360.0 -1870000.0 -1.55 7869720.0 -1103047.76470588 -0.927530420967321 -1.8858 -0.9569 3176139 HSCI1_000159 CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)CCCCCCCCC)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M07 compound treatment 3829000.0 -5360000.0 -4.61 3586680.0 -5560000.0 -4.61 4686440.0 -4286327.76470588 -3.60428580086163 -7.4084 -0.9939 671 HSCI1_000160 NC(=C(C#N)C#N)/C(=C/c1cc(O)c(O)c(O)c1)/C#N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M08 compound treatment 7530200.0 -1660000.0 -1.43 7855960.0 -1290000.0 -1.07 8009040.0 -963727.76470588 -0.810379067794846 -1.9114 -0.9747 3176140 HSCI1_000161 Nc1ncnc2n(cnc12)C3OC(CO)[C@H](O)[C@@H]3S 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M09 mock treatment 9738840.0 549000.0 0.47 9137320.0 -11300.0 -0.01 9449640.0 476872.23529412 0.400992159453696 0.4991 0.8049 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M10 mock treatment 9727080.0 538000.0 0.46 9733520.0 585000.0 0.49 9431840.0 459072.23529412 0.386024501640962 0.7702 0.9955 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M11 mock treatment 9562960.0 374000.0 0.32 9775320.0 627000.0 0.52 9245840.0 273072.23529412 0.22962088629442 0.6184 0.947 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M12 mock treatment 1.022252E7 1030000.0 0.89 9777320.0 629000.0 0.52 9747480.0 774712.23529412 0.65143975512474 1.1906 0.9764 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M13 mock treatment 1.006088E7 871000.0 0.75 9508920.0 360000.0 0.3 9574040.0 601272.23529412 0.505597588212351 0.8975 0.9421 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M14 mock treatment 9949560.0 760000.0 0.65 9446760.0 298000.0 0.25 9464240.0 491472.23529412 0.413269002378747 0.7591 0.9344 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M15 compound treatment 9710440.0 521000.0 0.45 9494440.0 346000.0 0.29 9112240.0 139472.23529412 0.117279364733678 0.4922 0.903 585 HSCI1_000162 Oc1ccc(C(=O)/C=C/c2ccc(O)c(O)c2)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M16 compound treatment 9035360.0 -154000.0 -0.13 8966760.0 -182000.0 -0.15 8608760.0 -364007.76470588 -0.30608672265706 -0.3404 -0.9297 2024 HSCI1_000163 CN(N=O)c1cc(O)ccc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M17 compound treatment 9625600.0 436000.0 0.38 9974840.0 826000.0 0.69 9721600.0 748832.23529412 0.629677789720608 0.976 0.9725 569 HSCI1_000164 COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M18 compound treatment 9022480.0 -167000.0 -0.14 8994360.0 -154000.0 -0.13 9284120.0 311352.23529412 0.261809759388321 -0.0057 -0.0174 1890 HSCI1_000165 CN(N=O)c1ccc(O)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M19 compound treatment 1522560.0 -7670000.0 -6.6 1905600.0 -7240000.0 -6.01 1577360.0 -7395407.76470588 -6.2186479105478 -10.869 -0.9992 1008455 HSCI1_000166 BrCC(=O)c1ccc(Br)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M20 compound treatment 4327400.0 -4860000.0 -4.18 4627520.0 -4520000.0 -3.75 3925720.0 -5047047.76470588 -4.24395977003594 -7.0315 -0.9985 3176141 HSCI1_000167 CCN(N=O)c1ccc(O)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M21 compound treatment 9473880.0 284000.0 0.24 9505400.0 357000.0 0.3 9038200.0 65432.2352941204 0.055020635269925 0.344 0.8865 560 HSCI1_000168 Oc1ccc(/C=C(\C#N)/C(=O)Nc2ccccc2)cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M22 compound treatment 8114560.0 -1070000.0 -0.93 5665560.0 -3480000.0 -2.89 8121920.0 -850847.76470588 -0.715460572631848 -2.6154 -0.839 566 HSCI1_000169 COc1cc(/C=C(\C#N)/C(=O)N)cc(CSc2nc3ccccc3s2)c1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M23 mock treatment 8867600.0 -322000.0 -0.28 8803800.0 -345000.0 -0.29 8811320.0 -161447.76470588 -0.135758140266761 -0.4034 -0.959 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 M24 mock treatment 8632680.0 -557000.0 -0.48 8828400.0 -320000.0 -0.27 8047680.0 -925087.76470588 -0.777887478026081 -0.8791 -0.924 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N01 mock treatment 8234720.0 -955000.0 -0.82 8218280.0 -930000.0 -0.77 8567200.0 -405567.76470588 -0.341033681010835 -1.1168 -0.9483 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N02 compound treatment 8521200.0 -668000.0 -0.58 8766280.0 -382000.0 -0.32 8406280.0 -566487.76470588 -0.476348034675167 -0.7902 -0.9739 837968 HSCI1_000170 Nc1ncnc2n(cnc12)C3CCCO3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N03 compound treatment 6317680.0 -2870000.0 -2.47 5397520.0 -3750000.0 -3.11 5776920.0 -3195847.76470588 -2.68732335751164 -4.775 -0.9954 3176143 HSCI1_000171 CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](OC(=O)CCC(=O)O)[C@@]3(C)O[C@](C)(CC(=O)[C@@]32O)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N04 compound treatment 816680.0 -8370000.0 -7.21 263200.0 -8890000.0 -7.37 270240.0 -8702527.76470588 -7.31777852179389 -12.6409 -1.0 831810 HSCI1_000172 Brc1c(Br)c(Br)c2[nH]nnc2c1Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N05 compound treatment 1.183384E7 2640000.0 2.28 9612880.0 464000.0 0.39 8986480.0 13712.2352941204 0.0115303396477575 1.543 0.6685 3054768 HSCI1_000173 C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@@]42OC(=O)/C=C\[C@H](O)CCC[C@@H](C)C/C=C\[C@H]4C(=O)C1=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N06 compound treatment 9665600.0 476000.0 0.41 9844400.0 696000.0 0.58 9787200.0 814432.23529412 0.684839494918098 0.9653 0.98 3054769 HSCI1_000174 Cn1sc(=O)n(Cc2ccccc2)c1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N07 compound treatment 1093280.0 -8100000.0 -6.97 849160.0 -8300000.0 -6.88 800000.0 -8172767.76470588 -6.87231411713806 -11.9657 -1.0 621 HSCI1_000175 CS(=O)c1ccc(cc1)c2nc(c([nH]2)c3ccncc3)c4cccc(I)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N08 compound treatment 8841800.0 -348000.0 -0.3 8975840.0 -173000.0 -0.14 8978960.0 6192.23529412039 0.0052069246617037 -0.2525 -0.761 3054770 HSCI1_000176 c1ccc(cc1)c2n[nH]c3c2oc4ccccc34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N09 mock treatment 9688160.0 499000.0 0.43 9537880.0 389000.0 0.32 9433400.0 460632.23529412 0.387336273898707 0.6579 0.9934 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N10 mock treatment 9554280.0 365000.0 0.31 9332800.0 184000.0 0.15 9089600.0 116832.23529412 0.0982418494033244 0.3262 0.8993 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N11 mock treatment 8940600.0 -249000.0 -0.21 9745320.0 597000.0 0.5 8959280.0 -13487.7647058796 -0.0113415868975434 0.1556 0.2885 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N12 mock treatment 9402840.0 213000.0 0.18 9711360.0 563000.0 0.47 9657120.0 684352.23529412 0.575457869733807 0.7078 0.9272 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N13 mock treatment 9801440.0 612000.0 0.53 9560960.0 412000.0 0.34 9383880.0 411112.23529412 0.345695913511822 0.7012 0.9781 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N14 mock treatment 9577920.0 389000.0 0.33 9397760.0 249000.0 0.21 9417120.0 444352.23529412 0.373646753157623 0.5281 0.9737 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N15 compound treatment 5456800.0 -3730000.0 -3.21 4807240.0 -4340000.0 -3.6 4687200.0 -4285567.76470588 -3.6036467323258 -6.0146 -0.9986 3176144 HSCI1_000177 CC1C2C(Cc3ccccc3)NC(=O)C42OC(=O)O/C=C\C(C)(O)C(=O)C(C)C/C=C\C4C5OC51C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N16 compound treatment 8661200.0 -528000.0 -0.45 8462320.0 -686000.0 -0.57 8909880.0 -62887.7647058796 -0.0528810417261412 -0.6217 -0.8511 1056418 HSCI1_000178 Nc1ncnc2n(cnc12)C3CCC(CO)O3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N17 compound treatment 8840000.0 -349000.0 -0.3 9284240.0 136000.0 0.11 8607760.0 -365007.76470588 -0.30692760230946 -0.2859 -0.6436 2177 HSCI1_000179 CC(C)CC[C@@H](O)[C@](C)(O)C1CC[C@@]2(O)C3=CC(=O)[C@]4(O)C[C@@H](O)[C@@H](O)C[C@]4(C)C3[C@H](O)C[C@]12C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N18 compound treatment 8976040.0 -213000.0 -0.18 9187360.0 38700.0 0.03 9239880.0 267112.23529412 0.224609243566111 0.0422 0.1447 3054771 HSCI1_000180 COc1ccc2NC(=O)/C(=C\c3c[nH]cn3)/c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N19 compound treatment 7861880.0 -1330000.0 -1.14 8352240.0 -796000.0 -0.66 8845640.0 -127127.76470588 -0.106899150596366 -1.1028 -0.8329 3176146 HSCI1_000181 CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)CCC)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N20 compound treatment 8667600.0 -522000.0 -0.45 8383120.0 -765000.0 -0.64 8713040.0 -259727.76470588 -0.218399792504708 -0.752 -0.9309 2127 HSCI1_000182 CC1(C)CCC2=C(O1)c3ccccc3C(=O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N21 compound treatment 7927720.0 -1260000.0 -1.09 7443480.0 -1710000.0 -1.41 6626480.0 -2346287.76470588 -1.97294564001805 -2.5827 -0.9711 3054772 HSCI1_000183 CC(C)(O)/C=C/C(=O)[C@](C)(O)C1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4C(C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@@]12C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N22 compound treatment 8865960.0 -323000.0 -0.28 8323440.0 -825000.0 -0.68 8211800.0 -760967.76470588 -0.639882309474067 -0.9254 -0.9467 1937872 HSCI1_000184 [O-][N+](=O)c1ccccc1c2ccc(C=C3C(=O)N(C(=S)N(C3=O)c4ccccc4)c5ccccc5)o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N23 mock treatment 8690960.0 -498000.0 -0.43 8439200.0 -709000.0 -0.59 8732320.0 -240447.76470588 -0.202187632806421 -0.7042 -0.9317 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 N24 mock treatment 7818440.0 -1370000.0 -1.18 7601960.0 -1550000.0 -1.28 8109120.0 -863647.76470588 -0.726223832182578 -1.8413 -0.9751 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O01 mock treatment 7220080.0 -1970000.0 -1.69 7955480.0 -1190000.0 -0.99 7426480.0 -1546287.76470588 -1.30024191809744 -2.3007 -0.9772 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O02 mock treatment 7814680.0 -1370000.0 -1.18 8108840.0 -1040000.0 -0.86 8177160.0 -795607.76470588 -0.66901038063323 -1.5673 -0.9736 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O03 compound treatment 353760.0 -8840000.0 -7.6 289640.0 -8860000.0 -7.35 267960.0 -8704807.76470588 -7.31969572740136 -12.8594 -0.9999 5 HSCI1_000185 CC(C)(C)c1cc(C=C(C#N)C#N)cc(c1O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O04 compound treatment 5323560.0 -3870000.0 -3.33 5518920.0 -3630000.0 -3.01 5191960.0 -3780807.76470588 -3.17920431897999 -5.4949 -0.9992 2090 HSCI1_000186 CCOC(=O)C(C#N)C1C(=C(N)Oc2ccc(Br)cc12)C(=O)OCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O05 compound treatment 7695560.0 -1490000.0 -1.29 6845360.0 -2300000.0 -1.91 6090600.0 -2882167.76470588 -2.42355622814657 -3.2447 -0.9705 2107241 HSCI1_000187 ClC1=C(N2C(=O)CCC2=O)C(=O)c3ccccc3C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O06 compound treatment 8890200.0 -299000.0 -0.26 8623480.0 -525000.0 -0.44 8830560.0 -142207.76470588 -0.11957961575457 -0.4692 -0.9024 651 HSCI1_000188 Nc1ncnc2n(ncc12)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O07 compound treatment 1082960.0 -8110000.0 -6.98 1022800.0 -8130000.0 -6.74 1244400.0 -7728367.76470588 -6.49862719961116 -11.6719 -0.9996 562 HSCI1_000189 Oc1ccc(/C=C(\C#N)/C(=O)c2ccc(O)c(O)c2)cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O08 compound treatment 302920.0 -8890000.0 -7.65 329600.0 -8820000.0 -7.32 3480760.0 -5492007.76470588 -4.61811758016818 -11.3058 -0.9791 3176147 HSCI1_000190 CS/C(=C(\C#N)/C(=C(\N)/SC)/[N+]#[C-])/N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O09 compound treatment 4796160.0 -4390000.0 -3.78 5126920.0 -4020000.0 -3.34 5079920.0 -3892847.76470588 -3.27341647523498 -5.9991 -0.9979 3176148 HSCI1_000191 OCc1cc2ncnc(Nc3ccc(O)cc3)c2cc1CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O10 compound treatment 1.056768E7 1380000.0 1.19 9940360.0 792000.0 0.66 9770240.0 797472.23529412 0.670578176013381 1.4512 0.9594 3054774 HSCI1_000192 Nc1ccc(cc1)c2cc(=O)c3cc(O)ccc3o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O11 mock treatment 9359200.0 170000.0 0.15 9357240.0 209000.0 0.17 9128560.0 155792.23529412 0.131002520660858 0.2599 0.9933 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O12 mock treatment 1.001684E7 827000.0 0.71 8998200.0 -150000.0 -0.12 9698160.0 725392.23529412 0.609967570668334 0.6913 0.7308 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O13 mock treatment 9867240.0 678000.0 0.58 9643680.0 495000.0 0.41 1.018048E7 1207712.23529412 1.01554064461427 1.1603 0.9349 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O14 mock treatment 9987640.0 798000.0 0.69 9076480.0 -72100.0 -0.06 9433080.0 460312.23529412 0.387067192409939 0.5856 0.7405 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O15 compound treatment 9062080.0 -127000.0 -0.11 8543680.0 -605000.0 -0.5 9187080.0 214312.23529412 0.180210797919351 -0.2489 -0.4573 3176208 HSCI1_000193 COc1ccc(N=O)c(CCc2cc(OC)ccc2N=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O16 compound treatment 3892400.0 -5300000.0 -4.56 3905360.0 -5240000.0 -4.35 3552680.0 -5420087.76470588 -4.55764151556752 -7.7747 -0.9998 3054775 HSCI1_000194 CC(C)(C)OC(=O)NC(CC(=O)O)C(=O)OCCF 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O17 compound treatment 8465920.0 -723000.0 -0.62 7625040.0 -1520000.0 -1.26 7011520.0 -1961247.76470588 -1.64917333865766 -2.0414 -0.9411 1860 HSCI1_000195 CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O18 compound treatment 9032960.0 -156000.0 -0.13 8623120.0 -525000.0 -0.44 9310120.0 337352.23529412 0.283672630350741 -0.1656 -0.3083 634 HSCI1_000196 OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O19 compound treatment 9144160.0 -45200.0 -0.04 8571120.0 -577000.0 -0.48 8726120.0 -246647.76470588 -0.207401086651306 -0.4188 -0.8 589 HSCI1_000197 Nc1cc(Nc2ccc(cc2)S(=O)(=O)N)ncn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O20 compound treatment 661160.0 -8530000.0 -7.34 472760.0 -8680000.0 -7.2 533280.0 -8439487.76470588 -7.09659353802639 -12.4901 -0.9999 3054776 HSCI1_000198 Oc1ccc2[nH]c(cc2c1)C(=O)c3cc4ccccc4[nH]3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O21 compound treatment 8993720.0 -196000.0 -0.17 9113200.0 -35400.0 -0.03 8832600.0 -140167.76470588 -0.117864221263672 -0.1822 -0.8777 557 HSCI1_000199 Cc1cc2ncc(nc2cc1C)c3ccc(O)c(O)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O22 compound treatment 8514240.0 -675000.0 -0.58 8933560.0 -215000.0 -0.18 8721840.0 -250927.76470588 -0.211000051563581 -0.5603 -0.8708 1000586 HSCI1_000200 O/N=C\1/C(=C\2/C(=O)Nc3ccccc23)/Nc4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O23 mock treatment 8231040.0 -958000.0 -0.82 8219920.0 -929000.0 -0.77 7882560.0 -1090207.76470588 -0.916733526230495 -1.4503 -0.9974 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 O24 mock treatment 7537000.0 -1650000.0 -1.42 8068320.0 -1080000.0 -0.9 7502960.0 -1469807.76470588 -1.23593144228183 -2.052 -0.9835 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P01 mock treatment 6409720.0 -2780000.0 -2.39 6956200.0 -2190000.0 -1.82 6182160.0 -2790607.76470588 -2.34656528717276 -3.786 -0.993 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P02 mock treatment 7567360.0 -1620000.0 -1.4 7294600.0 -1850000.0 -1.54 7325600.0 -1647167.76470588 -1.38506985743163 -2.4936 -0.9988 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P03 mock treatment 7593440.0 -1600000.0 -1.37 7973160.0 -1180000.0 -0.98 7611400.0 -1361367.76470588 -1.14474645277549 -2.0169 -0.9903 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P04 mock treatment 8060160.0 -1130000.0 -0.97 7869240.0 -1280000.0 -1.06 8197040.0 -775727.76470588 -0.652293693143503 -1.5505 -0.9813 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P05 mock treatment 9835000.0 646000.0 0.56 8393920.0 -755000.0 -0.63 8027960.0 -944807.76470588 -0.794469624771424 -0.4994 -0.4327 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P06 mock treatment 8625640.0 -564000.0 -0.49 8544080.0 -605000.0 -0.5 1.217504E7 3202272.23529412 2.69272556410674 0.985 0.3541 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P07 mock treatment 8549040.0 -640000.0 -0.55 8209280.0 -939000.0 -0.78 1.115944E7 2186672.23529412 1.83872818912852 0.2935 0.1417 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P08 mock treatment 8207120.0 -982000.0 -0.85 7928760.0 -1220000.0 -1.01 1.143768E7 2464912.23529412 2.07269454361251 0.1243 0.0506 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P09 mock treatment 8415080.0 -774000.0 -0.67 8192880.0 -956000.0 -0.79 9179040.0 206272.23529412 0.173450125514049 -0.7424 -0.7069 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P10 mock treatment 8797280.0 -392000.0 -0.34 8494240.0 -654000.0 -0.54 8508640.0 -464127.76470588 -0.390275593455424 -0.7336 -0.9795 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P11 mock treatment 8111320.0 -1080000.0 -0.93 7983160.0 -1170000.0 -0.97 8325520.0 -647247.76470588 -0.544257475403052 -1.4081 -0.9736 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P12 mock treatment 8957200.0 -232000.0 -0.2 7992480.0 -1160000.0 -0.96 8165960.0 -806807.76470588 -0.678428232740118 -1.0608 -0.8902 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P13 mock treatment 8423160.0 -766000.0 -0.66 8546400.0 -602000.0 -0.5 8686840.0 -285927.76470588 -0.240430839397608 -0.808 -0.9378 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P14 mock treatment 8273600.0 -916000.0 -0.79 7991760.0 -1160000.0 -0.96 7648360.0 -1324407.76470588 -1.11366754082275 -1.6521 -0.9904 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P15 mock treatment 8514480.0 -675000.0 -0.58 8459720.0 -689000.0 -0.57 7751040.0 -1221727.76470588 -1.02732601811424 -1.2584 -0.9597 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P16 mock treatment 7616360.0 -1570000.0 -1.35 7885760.0 -1260000.0 -1.05 8005760.0 -967007.76470588 -0.813137153054721 -1.8559 -0.9793 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P17 mock treatment 7977600.0 -1210000.0 -1.04 9931760.0 783000.0 0.65 7890680.0 -1082087.76470588 -0.909905583453001 -0.7524 -0.4921 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P18 mock treatment 8321600.0 -868000.0 -0.75 8294440.0 -854000.0 -0.71 7981400.0 -991367.76470588 -0.833620981387204 -1.3216 -0.9977 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P19 mock treatment 8136440.0 -1050000.0 -0.91 7929280.0 -1220000.0 -1.01 8076680.0 -896087.76470588 -0.753501968106459 -1.5422 -0.993 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P20 mock treatment 8106280.0 -1080000.0 -0.93 7709000.0 -1440000.0 -1.19 1.117008E7 2197312.23529412 1.84767514863007 -0.1609 -0.0674 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P21 mock treatment 7790120.0 -1400000.0 -1.2 7948200.0 -1200000.0 -1.0 8443960.0 -528807.76470588 -0.444663689372706 -1.527 -0.9398 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P22 mock treatment 7716920.0 -1470000.0 -1.27 7545160.0 -1600000.0 -1.33 7848640.0 -1124127.76470588 -0.945256164039929 -2.0454 -0.99 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P23 mock treatment 6452160.0 -2740000.0 -2.36 7342800.0 -1810000.0 -1.5 7178000.0 -1794767.76470588 -1.50918369412598 -3.0963 -0.9757 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2104 P24 mock treatment 6109320.0 -3080000.0 -2.65 6329760.0 -2820000.0 -2.34 6198080.0 -2774687.76470588 -2.33317848310654 -4.2276 -0.9982 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A01 mock treatment 7276640.0 -1640000.0 -1.41 4373120.0 -4820000.0 -4.0 7293200.0 -1815218.78453039 -1.52638054056725 -4.0076 -0.8885 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A02 mock treatment 7811440.0 -1110000.0 -0.95 6698000.0 -2500000.0 -2.07 7511600.0 -1596818.78453039 -1.34273242448293 -2.5224 -0.9527 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A03 mock treatment 8321040.0 -597000.0 -0.51 6420920.0 -2780000.0 -2.3 7904320.0 -1204098.78453039 -1.0125021673921 -2.2112 -0.861 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A04 mock treatment 8037800.0 -881000.0 -0.76 6041600.0 -3160000.0 -2.62 8300960.0 -807458.78453039 -0.678975662063859 -2.3411 -0.8335 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A05 mock treatment 8938000.0 19700.0 0.02 7032320.0 -2170000.0 -1.8 8477160.0 -631258.78453039 -0.530812667310844 -1.3337 -0.7121 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A06 mock treatment 8011080.0 -907000.0 -0.78 7780200.0 -1420000.0 -1.18 8213080.0 -895338.78453039 -0.752872165916838 -1.5643 -0.9779 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A07 mock treatment 8340920.0 -577000.0 -0.5 8287880.0 -910000.0 -0.75 8876920.0 -231498.78453039 -0.194662617467114 -0.835 -0.9034 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A08 mock treatment 8393440.0 -525000.0 -0.45 7701720.0 -1500000.0 -1.24 8591480.0 -516938.78453039 -0.434683305448388 -1.2282 -0.8834 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A09 mock treatment 8327320.0 -591000.0 -0.51 7793280.0 -1400000.0 -1.16 8280160.0 -828258.78453039 -0.696465958833795 -1.3683 -0.9441 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A10 mock treatment 8228480.0 -690000.0 -0.59 8503880.0 -694000.0 -0.58 8637360.0 -471058.78453039 -0.396103746996241 -0.9037 -0.9857 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A11 mock treatment 8105400.0 -813000.0 -0.7 8374600.0 -823000.0 -0.68 8841920.0 -266498.78453039 -0.224093405301141 -0.9274 -0.9248 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A12 mock treatment 8382760.0 -536000.0 -0.46 8459840.0 -738000.0 -0.61 8817680.0 -290738.78453039 -0.244476328075335 -0.7606 -0.9458 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A13 mock treatment 8378440.0 -540000.0 -0.46 8460960.0 -737000.0 -0.61 8480000.0 -628418.78453039 -0.528424569098026 -0.9261 -0.9938 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A14 mock treatment 8642000.0 -276000.0 -0.24 9022600.0 -175000.0 -0.15 8493320.0 -615098.78453039 -0.517224052128048 -0.5197 -0.8846 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A15 mock treatment 8441120.0 -477000.0 -0.41 9144200.0 -53300.0 -0.04 8477360.0 -631058.78453039 -0.530644491380364 -0.569 -0.8462 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A16 mock treatment 8455880.0 -462000.0 -0.4 9544160.0 347000.0 0.29 8494280.0 -614138.78453039 -0.516416807661743 -0.3619 -0.5079 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A17 mock treatment 8464720.0 -454000.0 -0.39 9626760.0 429000.0 0.36 8680960.0 -427458.78453039 -0.359441394151568 -0.2273 -0.3557 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A18 mock treatment 8185440.0 -733000.0 -0.63 9402680.0 205000.0 0.17 8473480.0 -634938.78453039 -0.533907104431679 -0.5741 -0.6805 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A19 mock treatment 8639960.0 -278000.0 -0.24 8828120.0 -369000.0 -0.31 8220120.0 -888298.78453039 -0.746952373163937 -0.7465 -0.8864 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A20 mock treatment 8208040.0 -710000.0 -0.61 8289280.0 -908000.0 -0.75 8615920.0 -492498.78453039 -0.414132206743714 -1.027 -0.9736 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A21 mock treatment 8234840.0 -683000.0 -0.59 7955560.0 -1240000.0 -1.03 8297240.0 -811178.78453039 -0.68210373437079 -1.3283 -0.9706 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A22 mock treatment 7819840.0 -1100000.0 -0.95 8209200.0 -988000.0 -0.82 9283040.0 174621.21546961 0.146835426965885 -0.9344 -0.7416 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A23 mock treatment 7539360.0 -1380000.0 -1.19 8350080.0 -847000.0 -0.7 8628600.0 -479818.78453039 -0.403469852751272 -1.324 -0.9213 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 A24 mock treatment 8234600.0 -684000.0 -0.59 7395840.0 -1800000.0 -1.49 8670360.0 -438058.78453039 -0.368354718467016 -1.4153 -0.8588 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B01 mock treatment 8174800.0 -744000.0 -0.64 8883160.0 -314000.0 -0.26 8472680.0 -635738.78453039 -0.534579808153599 -0.8286 -0.9485 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B02 mock treatment 8929200.0 10900.0 0.01 9262480.0 65000.0 0.05 8608760.0 -499658.78453039 -0.420152905054903 -0.206 -0.4863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B03 compound treatment 7649000.0 -1270000.0 -1.09 7853920.0 -1340000.0 -1.11 5550480.0 -3557938.78453039 -2.99179832839912 -3.0015 -0.8895 577 HSCI1_000201 CN1C(=O)C(=C(C1=O)c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B04 compound treatment 7410120.0 -1510000.0 -1.3 7280440.0 -1920000.0 -1.59 7353440.0 -1754978.78453039 -1.47572595030663 -2.5196 -0.9966 614 HSCI1_000202 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B05 compound treatment 8868480.0 -49800.0 -0.04 8471480.0 -726000.0 -0.6 9356800.0 248381.21546961 0.208858710126965 -0.2519 -0.3943 907102 HSCI1_000203 NCCCCCCNS(=O)(=O)c1cccc2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B06 compound treatment 9254080.0 336000.0 0.29 8744920.0 -453000.0 -0.38 9827280.0 718861.21546961 0.604475768988477 0.2991 0.3894 1012954 HSCI1_000204 OC(Cc1ccncc1)C(Cl)(Cl)Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B07 compound treatment 7578560.0 -1340000.0 -1.15 7536920.0 -1660000.0 -1.38 7771720.0 -1336698.78453039 -1.12400280930044 -2.11 -0.9957 3176210 HSCI1_000205 CCCC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c3cc4ccccc4[nH]3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B08 compound treatment 6472720.0 -2450000.0 -2.1 6394640.0 -2800000.0 -2.33 6295280.0 -2813138.78453039 -2.36551116329103 -3.9234 -0.9987 321 HSCI1_000206 O=c1cc(oc2c(cccc12)c3ccccc3)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B09 compound treatment 748880.0 -8170000.0 -7.03 1360120.0 -7840000.0 -6.5 1104240.0 -8004178.78453039 -6.73055107408949 -11.6989 -0.9995 3176211 HSCI1_000207 C[C@@H](O)[C@]1(C)CC[C@@H](O1)[C@]2(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)/C(=C/C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(=O)O)/O)O2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B10 compound treatment 9138120.0 220000.0 0.19 9482080.0 285000.0 0.24 9732560.0 624141.21546961 0.524827648313077 0.5485 0.9055 3103895 HSCI1_000208 C[C@@H]1CC2C3CCC4=CC(=O)C=CC4(C)[C@@]3(F)[C@@H](O)CC2(C)[C@@]1(O)C(=O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B11 mock treatment 9539600.0 621000.0 0.53 9540080.0 343000.0 0.28 9794320.0 685901.21546961 0.576760375645348 0.8058 0.9636 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B12 mock treatment 9229680.0 311000.0 0.27 9372440.0 175000.0 0.15 9612400.0 503981.21546961 0.423787549280601 0.4832 0.9257 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B13 mock treatment 9166400.0 248000.0 0.21 9548320.0 351000.0 0.29 9301120.0 192701.21546961 0.162038531081291 0.3848 0.9727 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B14 mock treatment 9199040.0 281000.0 0.24 9508400.0 311000.0 0.26 9442400.0 333981.21546961 0.280838008372471 0.4505 0.9981 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B15 compound treatment 5588440.0 -3330000.0 -2.87 4596120.0 -4600000.0 -3.82 2965760.0 -6142658.78453039 -5.16523678355242 -6.8406 -0.9726 1940 HSCI1_000209 NSC(=S)N1CCCC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B16 compound treatment 9011160.0 92800.0 0.08 9318960.0 121000.0 0.1 9742680.0 634261.21546961 0.533337350395372 0.4122 0.7514 1000071 HSCI1_000210 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B17 compound treatment 9694520.0 776000.0 0.67 9416320.0 219000.0 0.18 9841040.0 732621.21546961 0.616046273005512 0.8462 0.9131 3176212 HSCI1_000211 Nc1ncnc2n(cnc12)C3OC(CO)[C@H](O)[C@@H]3O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B18 compound treatment 9214080.0 296000.0 0.25 9577000.0 380000.0 0.31 8906880.0 -201538.78453039 -0.169469863081187 0.2309 0.5261 831767 HSCI1_000212 NCCCNCCCCNCCCN 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B19 compound treatment 9108520.0 190000.0 0.16 9632480.0 435000.0 0.36 9261880.0 153461.21546961 0.129042413521085 0.3773 0.9055 3054778 HSCI1_000213 NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B20 compound treatment 9776000.0 858000.0 0.74 1.030264E7 1110000.0 0.92 9865040.0 756621.21546961 0.63622738466313 1.3228 0.9887 2293 HSCI1_000214 CSC(=N)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B21 compound treatment 8126560.0 -792000.0 -0.68 8285440.0 -912000.0 -0.76 8435440.0 -672978.78453039 -0.565894166409004 -1.157 -0.9932 1001920 HSCI1_000215 CNC[C@H](O)c1ccc(O)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B22 compound treatment 8810400.0 -108000.0 -0.09 8946640.0 -251000.0 -0.21 8942480.0 -165938.78453039 -0.13953454745572 -0.2543 -0.9518 3054779 HSCI1_000216 CN/C(=N\C)/NCCC[C@H](N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B23 mock treatment 9282440.0 364000.0 0.31 8973800.0 -224000.0 -0.19 8614000.0 -494418.78453039 -0.415746695676323 -0.1662 -0.3008 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 B24 mock treatment 8010680.0 -908000.0 -0.78 8313200.0 -884000.0 -0.73 8281120.0 -827298.78453039 -0.69565871436749 -1.2762 -0.9989 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C01 mock treatment 8358400.0 -560000.0 -0.48 5303000.0 -3890000.0 -3.23 8194360.0 -914058.78453039 -0.76861343300978 -2.5873 -0.771 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C02 mock treatment 8999600.0 81300.0 0.07 7447800.0 -1750000.0 -1.45 9020160.0 -88258.7845303901 -0.0742150160572284 -0.8405 -0.5776 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C03 compound treatment 8988880.0 70600.0 0.06 6905880.0 -2290000.0 -1.9 9397720.0 289301.21546961 0.243267505503204 -0.9221 -0.4809 2022 HSCI1_000217 CC1(C)C(C=C(Br)Br)C1C(=O)OC(C#N)c2cccc(Oc3ccccc3)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C04 compound treatment 9092440.0 174000.0 0.15 7934280.0 -1260000.0 -1.05 9466480.0 358061.21546961 0.301086390402281 -0.3447 -0.3132 3176214 HSCI1_000218 COc1ccc2c(cc(C)c3nnc(SCC(=O)Nc4cccc(c4)C(=O)C)n32)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C05 compound treatment 7981800.0 -937000.0 -0.81 6687840.0 -2510000.0 -2.08 8136120.0 -972298.78453039 -0.817586263965601 -2.1394 -0.8998 3054780 HSCI1_000219 CCCCc1c([nH]c2nccnc12)c3ccc(O)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C06 compound treatment 8576880.0 -341000.0 -0.29 9031520.0 -166000.0 -0.14 8965360.0 -143058.78453039 -0.12029522100879 -0.3186 -0.9206 3054781 HSCI1_000220 NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C07 compound treatment 8973240.0 54900.0 0.05 9623040.0 426000.0 0.35 9127720.0 19301.2154696099 0.0162299993549979 0.2405 0.6745 360 HSCI1_000221 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C08 compound treatment 8024920.0 -893000.0 -0.77 7418520.0 -1780000.0 -1.48 7912240.0 -1196178.78453039 -1.00584240054508 -1.8767 -0.9652 2260 HSCI1_000222 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(CO)c8c1c2c(c34)c(c65)c78 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C09 compound treatment 8726120.0 -192000.0 -0.17 8144320.0 -1050000.0 -0.87 8822200.0 -286218.78453039 -0.240675552046484 -0.7389 -0.8021 3054782 HSCI1_000223 O=c1cc(oc2c1ccc3ccccc32)N4CCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C10 compound treatment 8354440.0 -564000.0 -0.49 7979080.0 -1220000.0 -1.01 8431480.0 -676938.78453039 -0.569224049832511 -1.1924 -0.9483 3176215 HSCI1_000224 C1CCC(CC1)n2cnc3c(Nc4ccc(cc4)N5CCOCC5)nc(Oc6cccc7ccccc67)nc23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C11 mock treatment 9663480.0 745000.0 0.64 9301120.0 104000.0 0.09 9311480.0 203061.21546961 0.170750044280162 0.5185 0.7748 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C12 mock treatment 9748880.0 831000.0 0.71 1.002016E7 823000.0 0.68 9560200.0 451781.21546961 0.379893631425281 1.026 0.9691 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C13 mock treatment 9732960.0 815000.0 0.7 1.001172E7 814000.0 0.68 1.018164E7 1073221.21546961 0.902449882613212 1.3158 0.9912 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C14 mock treatment 9530440.0 612000.0 0.53 1.016756E7 970000.0 0.8 9405280.0 296861.21546961 0.249624555675354 0.9129 0.9187 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C15 mock treatment 8994400.0 76100.0 0.07 9874240.0 677000.0 0.56 9394480.0 286061.21546961 0.240543055429426 0.5008 0.8153 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C16 mock treatment 9077960.0 160000.0 0.14 1.014736E7 950000.0 0.79 9930840.0 822421.21546961 0.6915572657911 0.9335 0.8829 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C17 compound treatment 9856160.0 938000.0 0.81 1.044292E7 1250000.0 1.03 9309240.0 200821.21546961 0.168866473858785 1.16 0.8775 3176216 HSCI1_000225 CCCCCCCCCCCCCCCCC(=C)OOCC(COP(=O)(ON)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(=O)(O)ON)[C@H](OP(=O)(O)ON)[C@H]1O)OOC(=C)CC/C=C/C/C=C/C\C=C\C\C=C\CCCCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C18 compound treatment 9768960.0 851000.0 0.73 9528800.0 331000.0 0.27 9440640.0 332221.21546961 0.279358060184245 0.7426 0.8943 907140 HSCI1_000226 NCCCCNS(=O)(=O)c1ccc2ccccc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C19 compound treatment 9347160.0 429000.0 0.37 1.009476E7 897000.0 0.74 8681000.0 -427418.78453039 -0.359407758965472 0.4353 0.4809 3054783 HSCI1_000227 Nc1nc2n(cnc2c(=O)[nH]1)C3OC(COP(=O)(O)OP(=S)(O)O)[C@H](O)[C@@H]3O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C20 compound treatment 2374880.0 -6540000.0 -5.63 2784560.0 -6410000.0 -5.32 2560080.0 -6548338.78453039 -5.50636484093836 -9.502 -0.9997 2081802 HSCI1_000228 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccc(O)c(CN(C)C)c5cc4Cn3c2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C21 compound treatment 5280640.0 -3640000.0 -3.13 4906360.0 -4290000.0 -3.56 3481400.0 -5627018.78453039 -4.73164559958849 -6.5946 -0.9846 3176218 HSCI1_000229 Nc1nc2n(C3OC4COP(O)(O)OC4C3O)c(Br)nc2c(=O)[nH]1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C22 compound treatment 6633600.0 -2280000.0 -1.97 6441120.0 -2760000.0 -2.29 5548960.0 -3559458.78453039 -2.99307646547076 -4.1835 -0.9846 3054784 HSCI1_000230 Nc1nc(Cl)nc2n(cnc12)C3C[C@@H](O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C23 compound treatment 7570200.0 -1350000.0 -1.16 7245200.0 -1950000.0 -1.62 6859520.0 -2248898.78453039 -1.89105322822042 -2.6967 -0.9817 1338 HSCI1_000231 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 C24 mock treatment 8725120.0 -193000.0 -0.17 8505960.0 -692000.0 -0.57 8470200.0 -638218.78453039 -0.536665189691553 -0.7371 -0.9179 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D01 mock treatment 9203160.0 285000.0 0.25 9214800.0 17300.0 0.01 8665640.0 -442778.78453039 -0.372323670426348 -0.0651 -0.1461 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D02 mock treatment 9112880.0 195000.0 0.17 9047640.0 -150000.0 -0.12 9882720.0 774301.21546961 0.651094136917576 0.4008 0.5863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D03 compound treatment 4776360.0 -4140000.0 -3.56 4786320.0 -4410000.0 -3.66 5183880.0 -3924538.78453039 -3.30006480896924 -6.0761 -0.9991 3176219 HSCI1_000232 O/N=C/1\C(=C/2\C(=O)Nc3cc(Br)ccc23)\Nc4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D04 compound treatment 7434560.0 -1480000.0 -1.28 7223280.0 -1970000.0 -1.64 7773400.0 -1335018.78453039 -1.12259013148441 -2.331 -0.9874 3054785 HSCI1_000233 O=C1NC(=O)c2c1ccc(Nc3ccccc3)c2Nc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D05 compound treatment 7777760.0 -1140000.0 -0.98 7360920.0 -1840000.0 -1.52 7968560.0 -1139858.78453039 -0.958484058521873 -1.9998 -0.9754 1277018 HSCI1_000234 COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D06 compound treatment 7758040.0 -1160000.0 -1.0 7995320.0 -1200000.0 -1.0 8696000.0 -412418.78453039 -0.34679456417946 -1.3525 -0.9307 1919 HSCI1_000235 CCCCCc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D07 compound treatment 8713760.0 -205000.0 -0.18 9064880.0 -133000.0 -0.11 8275200.0 -833218.78453039 -0.700636721909702 -0.5697 -0.7796 3176221 HSCI1_000236 C1C[C@H](N/C/2=N/CCCCCCCCCCC2)[C@@H](C1)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D08 compound treatment 9020400.0 102000.0 0.09 8885680.0 -312000.0 -0.26 9254280.0 145861.21546961 0.122651728162839 -0.0278 -0.0929 3054786 HSCI1_000237 OCC1OC([C@@H](O)[C@H]1O)n2cnc3cc(Cl)c(Cl)cc23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D09 compound treatment 6696880.0 -2220000.0 -1.91 4880880.0 -4320000.0 -3.58 5300720.0 -3807698.78453039 -3.20181643038273 -5.0198 -0.9709 3176222 HSCI1_000238 COc1cc2ncnc(Nc3ccc(OCc4ccccc4)cc3)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D10 compound treatment 9347760.0 429000.0 0.37 9353320.0 156000.0 0.13 1.011796E7 1009541.21546961 0.848902666348332 0.7781 0.8324 407 HSCI1_000239 [O-][N+](=O)c1cccc2c(Br)n[nH]c12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D11 mock treatment 9676280.0 758000.0 0.65 9505440.0 308000.0 0.26 9237640.0 129221.21546961 0.10865949074689 0.5868 0.8278 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D12 mock treatment 1.000784E7 1090000.0 0.94 9995200.0 798000.0 0.66 1.003308E7 924661.21546961 0.777528801452555 1.3723 0.99 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D13 mock treatment 9440760.0 522000.0 0.45 9454400.0 257000.0 0.21 9712400.0 603981.21546961 0.507875514520677 0.6759 0.9506 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D14 mock treatment 9516560.0 598000.0 0.51 1.0492E7 1290000.0 1.07 9241120.0 132701.21546961 0.111585751937245 0.9817 0.8207 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D15 mock treatment 9726240.0 808000.0 0.7 9434560.0 237000.0 0.2 9475240.0 366821.21546961 0.308452496157312 0.6931 0.8821 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D16 mock treatment 9491400.0 573000.0 0.49 9970280.0 773000.0 0.64 9783520.0 675101.21546961 0.56767887539942 0.9826 0.9944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D17 compound treatment 9635560.0 717000.0 0.62 9304160.0 107000.0 0.09 9270000.0 161581.21546961 0.135870356298579 0.4859 0.7614 3054787 HSCI1_000240 N/N=C(/N)\NO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D18 compound treatment 9801400.0 883000.0 0.76 1.026852E7 1070000.0 0.89 9890320.0 781901.21546961 0.657484822275821 1.3314 0.9925 907294 HSCI1_000241 CN(C)C(=N)NCCC[C@H](N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D19 compound treatment 9547040.0 629000.0 0.54 9673200.0 476000.0 0.39 9830600.0 722181.21546961 0.607267489434448 0.8908 0.9854 3176223 HSCI1_000242 CSC(=N)NCCC[C@H](N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D20 compound treatment 9276160.0 358000.0 0.31 9666360.0 469000.0 0.39 9523960.0 415541.21546961 0.349420152822277 0.6041 0.9955 3054789 HSCI1_000243 CNC(=N)NCCC[C@@H](N)C=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D21 compound treatment 8860160.0 -58200.0 -0.05 9632240.0 435000.0 0.36 8774920.0 -333498.78453039 -0.280432342011992 0.0174 0.0379 3176224 HSCI1_000244 OP(=O)(O)C(Cl)(Cl)P(=O)(O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D22 compound treatment 9394640.0 476000.0 0.41 9652120.0 455000.0 0.38 8930440.0 -177978.78453039 -0.149658738470625 0.368 0.638 3176225 HSCI1_000245 CNC(=N)NCCC[C@H](N)C=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D23 compound treatment 9455480.0 537000.0 0.46 9580480.0 383000.0 0.32 9228560.0 120141.21546961 0.101024303503091 0.5087 0.8924 2215 HSCI1_000246 CCCNC(=N)NCCCC(N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 D24 mock treatment 8525120.0 -393000.0 -0.34 8898600.0 -299000.0 -0.25 8496560.0 -611858.78453039 -0.514499602054269 -0.6356 -0.9574 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E01 mock treatment 8816520.0 -102000.0 -0.09 5344560.0 -3850000.0 -3.2 8980040.0 -128378.78453039 -0.107951107711547 -1.9583 -0.6121 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E02 mock treatment 9549240.0 631000.0 0.54 8038200.0 -1160000.0 -0.96 9433360.0 324941.21546961 0.273236456314768 -0.084 -0.0738 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E03 mock treatment 9100400.0 182000.0 0.16 7171840.0 -2030000.0 -1.68 9127040.0 18621.2154696099 0.0156582011913654 -0.8707 -0.5159 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E04 mock treatment 9274560.0 356000.0 0.31 7690800.0 -1510000.0 -1.25 9782320.0 673901.21546961 0.566669819816539 -0.2175 -0.1546 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E05 compound treatment 8462040.0 -456000.0 -0.39 7643000.0 -1550000.0 -1.29 8895600.0 -212818.78453039 -0.178954985560268 -1.0746 -0.7902 3176226 HSCI1_000247 CCCCc1c([nH]c2nccnc12)c3ccc(OC)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E06 compound treatment 9524440.0 606000.0 0.52 1.002244E7 825000.0 0.68 1.007832E7 969901.21546961 0.815570196927165 1.1672 0.9845 2371 HSCI1_000248 CCCCCCCCNC(=O)C(Cc1ccc(OCc2ccncc2)cc1)NC(=O)C3CCC(CN)CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E07 compound treatment 2575680.0 -6340000.0 -5.46 3078120.0 -6120000.0 -5.08 2759800.0 -6348618.78453039 -5.33842435676088 -9.1646 -0.9995 1989 HSCI1_000249 Clc1[nH]c2ccccc2c1/C=C\3/C(=O)Nc4ccccc34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E08 compound treatment 596120.0 -8320000.0 -7.16 432840.0 -8760000.0 -7.27 437760.0 -8670658.78453039 -7.29098054482156 -12.5425 -1.0 1416171 HSCI1_000250 OC(CN1CCNCC1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E09 mock treatment 9396280.0 478000.0 0.41 9189600.0 -7900.0 -0.01 9742680.0 634261.21546961 0.533337350395372 0.5416 0.8041 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E10 mock treatment 9689960.0 772000.0 0.66 9618000.0 421000.0 0.35 9599520.0 491101.21546961 0.412957019357679 0.8232 0.9614 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E11 compound treatment 9116320.0 198000.0 0.17 9351840.0 154000.0 0.13 9318200.0 209781.21546961 0.176400755544296 0.2742 0.9909 663 HSCI1_000251 Fc1ccc(cc1)c2nc3SCCn3c2c4ccncc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E12 compound treatment 6287520.0 -2630000.0 -2.26 7256640.0 -1940000.0 -1.61 5953520.0 -3154898.78453039 -2.65289019329551 -3.7684 -0.981 1000089 HSCI1_000252 COC1C(C)OC(OC2CC(C)(O)C(C(=O)OC)c3cc4C(=O)c5c6OC7OC(C)(C(O)C(C7O)N(C)C)c6cc(O)c5C(=O)c4c(O)c23)C(OC)C1(C)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E13 compound treatment 9566640.0 648000.0 0.56 1.02614E7 1060000.0 0.88 9789520.0 681101.21546961 0.572724153313824 1.1624 0.976 3054791 HSCI1_000253 Nc1nc2n(cnc2c(=O)[nH]1)C3OC4COP(O)(O)OC4C3O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E14 compound treatment 9438920.0 521000.0 0.45 1.089656E7 1700000.0 1.41 9798360.0 689941.21546961 0.580157529441047 1.4074 0.8859 3176276 HSCI1_000254 NCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N[N+](=O)[O-])C(=O)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E15 mock treatment 9440640.0 522000.0 0.45 9606680.0 409000.0 0.34 9898680.0 790261.21546961 0.664514576169892 0.8392 0.9633 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E16 mock treatment 9551680.0 633000.0 0.55 1.014188E7 944000.0 0.78 9060160.0 -48258.7845303901 -0.0405798299611978 0.7436 0.7784 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E17 mock treatment 9667520.0 749000.0 0.64 9780440.0 583000.0 0.48 9861720.0 753301.21546961 0.633435664217159 1.0172 0.9923 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E18 mock treatment 9444040.0 526000.0 0.45 9898320.0 701000.0 0.58 9997160.0 888741.21546961 0.747324404338319 1.0284 0.98 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E19 compound treatment 9300160.0 382000.0 0.33 1.01454E7 948000.0 0.79 9367480.0 259061.21546961 0.217839304814605 0.7695 0.8748 1000095 HSCI1_000255 CC(O)C(O)[C@H]1CNc2nc(N)[nH]c(=O)c2N1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E20 compound treatment 9103840.0 186000.0 0.16 9427200.0 230000.0 0.19 9765480.0 657061.21546961 0.55250940647011 0.5212 0.8602 3054834 HSCI1_000256 NCCNC[C@@H](N)CCCNC(=N)N[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E21 compound treatment 8945160.0 26800.0 0.02 9413240.0 216000.0 0.18 8819200.0 -289218.78453039 -0.243198191003686 -0.0237 -0.0784 423 HSCI1_000257 COC(=O)[C@@H](N)CCCNC(=N)N[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E22 compound treatment 9456040.0 538000.0 0.46 9729360.0 532000.0 0.44 8982680.0 -125738.78453039 -0.105731185429209 0.4609 0.7111 2114444 HSCI1_000258 O=c1n(CCN2CCCCC2)c(=O)c3ccc4c5ccc6c(=O)n(CCN7CCCCC7)c(=O)c8ccc(c9ccc1c3c94)c5c86 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E23 compound treatment 9267080.0 349000.0 0.3 9041040.0 -156000.0 -0.13 8609000.0 -499418.78453039 -0.419951093938327 -0.1441 -0.2707 832002 HSCI1_000259 CC(=N)NCCC[C@H](N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 E24 mock treatment 8256720.0 -662000.0 -0.57 8993520.0 -204000.0 -0.17 8540720.0 -567698.78453039 -0.477366356604251 -0.702 -0.9213 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F01 mock treatment 8445240.0 -473000.0 -0.41 8472600.0 -725000.0 -0.6 7799200.0 -1309218.78453039 -1.10089543645247 -1.2179 -0.9234 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F02 mock treatment 9591840.0 674000.0 0.58 9504640.0 307000.0 0.25 9563360.0 454941.21546961 0.382550811126867 0.7026 0.9498 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F03 mock treatment 8800200.0 -118000.0 -0.1 9815320.0 618000.0 0.51 9632680.0 524261.21546961 0.440840588631288 0.4917 0.7193 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F04 mock treatment 8965400.0 47100.0 0.04 9427080.0 230000.0 0.19 9754320.0 645901.21546961 0.543125189549317 0.4469 0.7746 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F05 compound treatment 4767920.0 -4150000.0 -3.57 4991440.0 -4210000.0 -3.49 5112720.0 -3995698.78453039 -3.35990180503407 -6.0166 -0.9997 3176278 HSCI1_000260 CC(=O)O/N=C/1\C(=C/2\C(=O)Nc3cc(Br)ccc23)\Nc4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F06 compound treatment 9300960.0 383000.0 0.33 9081680.0 -116000.0 -0.1 9705320.0 596901.21546961 0.50192208658168 0.4244 0.6982 1505 HSCI1_000261 CC(C)Cn1c(=O)n(C)c(=O)c2[nH]cnc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F07 compound treatment 3318200.0 -5600000.0 -4.82 3474800.0 -5720000.0 -4.75 3451400.0 -5657018.78453039 -4.75687198916051 -8.2699 -1.0 3054836 HSCI1_000262 COc1ccc(CNc2nc(nc3n(cnc23)C(C)C)N(CCO)CCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F08 compound treatment 2408240.0 -6510000.0 -5.6 2386240.0 -6810000.0 -5.65 2218360.0 -6890058.78453039 -5.79371023575675 -9.8421 -0.9999 1980 HSCI1_000263 CC1(C2CCC(O2)C1(C)C(=O)O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F09 mock treatment 9152320.0 234000.0 0.2 9048360.0 -149000.0 -0.12 1.0026E7 917581.21546961 0.771575373513557 0.4903 0.6076 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F10 mock treatment 9986520.0 1070000.0 0.92 9821200.0 624000.0 0.52 9779480.0 671061.21546961 0.564281721603721 1.1553 0.9657 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F11 compound treatment 9523120.0 605000.0 0.52 1.000688E7 809000.0 0.67 9857480.0 749061.21546961 0.62987033449098 1.0518 0.9946 832084 HSCI1_000264 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c4nc[nH]c4n2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F12 compound treatment 9490800.0 572000.0 0.49 9566720.0 369000.0 0.31 9907360.0 798941.21546961 0.67181341155273 0.8492 0.9567 445 HSCI1_000265 NC(=O)c1cccc(N)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F13 compound treatment 9533640.0 615000.0 0.53 9924760.0 727000.0 0.6 1.062156E7 1513141.21546961 1.27236965929736 1.3887 0.923 2194 HSCI1_000266 OS(=O)(=O)c1cc(c2c(NC(=O)c3cccc(c3)[N+](=O)[O-])ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F14 compound treatment 9095840.0 178000.0 0.15 9659600.0 462000.0 0.38 9543400.0 434981.21546961 0.365766853264948 0.5207 0.9443 2025 HSCI1_000267 NCCCC(N)(C(F)F)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F15 mock treatment 9717400.0 799000.0 0.69 9373880.0 176000.0 0.15 9453040.0 344621.21546961 0.289784967874015 0.6488 0.8532 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F16 mock treatment 9428160.0 510000.0 0.44 9594960.0 397000.0 0.33 9514520.0 406101.21546961 0.341482248903614 0.6409 0.9914 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F17 mock treatment 9108520.0 190000.0 0.16 9579760.0 382000.0 0.32 9893320.0 784901.21546961 0.660007461233024 0.6586 0.8778 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F18 mock treatment 9378480.0 460000.0 0.4 9527680.0 330000.0 0.27 9537240.0 428821.21546961 0.360587034606159 0.595 0.989 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F19 compound treatment 9137720.0 219000.0 0.19 8982440.0 -215000.0 -0.18 9366200.0 257781.21546961 0.216762978859532 0.1312 0.3877 2259 HSCI1_000268 CN1CCc2cc3OCOc3cc2C(=O)Cc4ccc5OCOc5c4C1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F20 compound treatment 9034000.0 116000.0 0.1 9191840.0 -5660.0 0.0 9508440.0 400021.21546961 0.336369700617017 0.249 0.7097 2674 HSCI1_000269 N[C@@H](CCC(=O)O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F21 compound treatment 3778120.0 -5140000.0 -4.42 3844240.0 -5350000.0 -4.44 3747000.0 -5361418.78453039 -4.50830796391085 -7.7209 -1.0 3176279 HSCI1_000270 CC[C@]1(O)C[C@H]2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)[C@@H]7[C@@]86CCN9CC=C[C@@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F22 compound treatment 8888640.0 -29700.0 -0.03 9244520.0 47000.0 0.04 8838680.0 -269738.78453039 -0.226817855374919 -0.1232 -0.532 2129 HSCI1_000271 OCC(O)C1OC(=O)C(=C1O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F23 compound treatment 3521040.0 -5400000.0 -4.65 2820640.0 -6380000.0 -5.29 2477560.0 -6630858.78453039 -5.57575422985447 -8.9552 -0.9972 1000078 HSCI1_000272 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](OC5CC(N)C(O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 F24 mock treatment 8478160.0 -440000.0 -0.38 8430320.0 -767000.0 -0.64 8316680.0 -791738.78453039 -0.665757033928119 -0.9705 -0.9745 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G01 mock treatment 8183920.0 -734000.0 -0.63 5277960.0 -3920000.0 -3.25 7981560.0 -1126858.78453039 -0.947552623040663 -2.7893 -0.8096 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G02 compound treatment 7159200.0 -1760000.0 -1.51 5673560.0 -3520000.0 -2.92 9069920.0 -38498.7845303901 -0.0323728445537663 -2.5806 -0.7838 25 HSCI1_000273 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)OCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G03 mock treatment 9232600.0 314000.0 0.27 7226000.0 -1970000.0 -1.64 9936040.0 827621.21546961 0.695929839983584 -0.3863 -0.2149 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G04 mock treatment 9208280.0 290000.0 0.25 8365920.0 -832000.0 -0.69 9661280.0 552861.21546961 0.46488974668995 0.0142 0.0163 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G05 mock treatment 9484440.0 566000.0 0.49 8909880.0 -288000.0 -0.24 9758600.0 650181.21546961 0.546724154461593 0.4592 0.5962 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G06 mock treatment 9313600.0 395000.0 0.34 1.006176E7 864000.0 0.72 1.012204E7 1013621.21546961 0.852333455330127 1.1024 0.9466 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G07 compound treatment 9018720.0 100000.0 0.09 9481600.0 284000.0 0.24 9118400.0 9981.21546960995 0.00839300099462275 0.1908 0.7597 3054838 HSCI1_000274 CC(C)(c1ccc(NS(=O)(=O)C(F)(F)F)cc1)c2ccc(cc2)C(C)(C)c3cccc(NS(=O)(=O)C(F)(F)F)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G08 compound treatment 9769520.0 851000.0 0.73 9264680.0 67200.0 0.06 9573480.0 465061.21546961 0.391060513209163 0.6809 0.8181 546 HSCI1_000275 Cc1ncc2ccccc2c1C#N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G09 compound treatment 5969000.0 -2950000.0 -2.54 5349200.0 -3850000.0 -3.19 7107200.0 -2001218.78453039 -1.6827841559138 -4.2802 -0.9701 1947905 HSCI1_000276 Clc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G10 compound treatment 9005240.0 86900.0 0.07 8783280.0 -414000.0 -0.34 8993160.0 -115258.78453039 -0.0969187666720491 -0.2112 -0.5789 636 HSCI1_000277 C/C(=C(\C#N)/C(=O)Nc1cccc(F)c1)/O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G11 compound treatment 7699840.0 -1220000.0 -1.05 6911640.0 -2290000.0 -1.9 7933360.0 -1175058.78453039 -0.98808302228638 -2.2707 -0.9535 3176281 HSCI1_000278 COc1ccc(CNC(=O)Nc2ncc(s2)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G12 compound treatment 9638800.0 720000.0 0.62 1.047504E7 1280000.0 1.06 1.058348E7 1475061.21546961 1.24034896213394 1.686 0.966 3054840 HSCI1_000279 CC1OC(C[C@H]1O)n2cnc3c(N)ncnc23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G13 compound treatment 661600.0 -8260000.0 -7.11 741800.0 -8460000.0 -7.01 582480.0 -8525938.78453039 -7.16928844152612 -12.2918 -1.0 2319 HSCI1_000280 CN(C)CC1Cc2ccccc2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G14 compound treatment 9068280.0 150000.0 0.13 9859800.0 662000.0 0.55 9594120.0 485701.21546961 0.408416269234715 0.6275 0.9008 3176282 HSCI1_000281 N[C@@H](CCN/C(=N/O)/N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G15 compound treatment 8850520.0 -67800.0 -0.06 1.02088E7 1010000.0 0.84 8592840.0 -515578.78453039 -0.433539709121123 0.2004 0.2118 2145 HSCI1_000282 NC(=N)NCCS 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G16 compound treatment 9361640.0 443000.0 0.38 1.057616E7 1380000.0 1.14 9666080.0 557661.21546961 0.468925969021474 1.1513 0.89 3583 HSCI1_000283 Cn1cc(NC(=O)c2cc(NC(=O)CNC(=N)N)cn2C)cc1C(=O)NCCC(=N)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G17 mock treatment 9308840.0 391000.0 0.34 1.014012E7 943000.0 0.78 9564120.0 455701.21546961 0.383189879662692 0.8668 0.9286 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G18 mock treatment 9891160.0 973000.0 0.84 9635680.0 438000.0 0.36 9296440.0 188021.21546961 0.158103214308055 0.7845 0.8469 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G19 mock treatment 9091120.0 173000.0 0.15 9219360.0 21900.0 0.02 9061800.0 -46618.7845303901 -0.0392007873312606 0.0737 0.4759 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G20 mock treatment 9242000.0 324000.0 0.28 9700880.0 503000.0 0.42 9442360.0 333941.21546961 0.280804373186375 0.5641 0.9806 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G21 compound treatment 8960600.0 42300.0 0.04 9051400.0 -146000.0 -0.12 8834960.0 -273458.78453039 -0.22994592768185 -0.1817 -0.6924 1030173 HSCI1_000284 NC(=N)NO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G22 compound treatment 7048440.0 -1870000.0 -1.61 1830560.0 -7370000.0 -6.11 1404040.0 -7704378.78453039 -6.47845535429974 -8.1979 -0.9058 3176283 HSCI1_000285 COc1cc(ccc1[n+]2nc(nn2c3ccc(cc3)[N+](=O)[O-])c4ccccc4)c5ccc(c(OC)c5)[n+]6nc(nn6c7ccc(cc7)[N+](=O)[O-])c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G23 compound treatment 8943400.0 25100.0 0.02 9275200.0 77700.0 0.06 8639480.0 -468938.78453039 -0.394321082133152 -0.178 -0.4448 469 HSCI1_000286 CCCC(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 G24 mock treatment 9052800.0 134000.0 0.12 9432720.0 235000.0 0.2 8998960.0 -109458.78453039 -0.0920416646881246 0.1263 0.516 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H01 mock treatment 9004080.0 85800.0 0.07 9348960.0 151000.0 0.13 9438520.0 330101.21546961 0.277575395321156 0.2754 0.8785 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H02 compound treatment 9668440.0 750000.0 0.65 9894360.0 697000.0 0.58 9658280.0 549861.21546961 0.462367107732748 0.9734 0.9911 1594 HSCI1_000287 N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H03 mock treatment 9583320.0 665000.0 0.57 9634440.0 437000.0 0.36 9806960.0 698541.21546961 0.587389094451694 0.8788 0.9801 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H04 mock treatment 9327000.0 409000.0 0.35 9509960.0 312000.0 0.26 1.016056E7 1052141.21546961 0.884724139540604 0.8635 0.8751 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H05 mock treatment 9400720.0 482000.0 0.42 9720560.0 523000.0 0.43 9574360.0 465941.21546961 0.391800487303276 0.7164 0.9991 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H06 mock treatment 9315320.0 397000.0 0.34 9577360.0 380000.0 0.32 9549000.0 440581.21546961 0.370475779318392 0.5931 0.9978 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H07 compound treatment 8575200.0 -343000.0 -0.3 8654160.0 -543000.0 -0.45 9124360.0 15941.2154696099 0.0134046437229313 -0.423 -0.7847 3054842 HSCI1_000288 CSc1nc(c([nH]1)c2ccnc(NC(C)c3ccccc3)c2)c4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H08 compound treatment 9653480.0 735000.0 0.63 9747680.0 550000.0 0.46 1.020456E7 1096141.21546961 0.921722844246238 1.161 0.9614 1961 HSCI1_000289 CC(C)(C)c1cc(O)c(cc1O)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H09 compound treatment 8155280.0 -763000.0 -0.66 7480680.0 -1720000.0 -1.42 8094640.0 -1013778.78453039 -0.852465951947185 -1.6936 -0.9488 572 HSCI1_000290 CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H10 compound treatment 6248040.0 -2670000.0 -2.3 9797640.0 600000.0 0.5 1.002356E7 915141.21546961 0.769523627161699 -0.5951 -0.2405 1907755 HSCI1_000291 COCc1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H11 compound treatment 3862760.0 -5060000.0 -4.35 4065080.0 -5130000.0 -4.26 4211440.0 -4896978.78453039 -4.11776981814984 -7.3476 -0.9997 574 HSCI1_000292 NCCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H12 compound treatment 3420920.0 -5500000.0 -4.73 3566360.0 -5630000.0 -4.67 3669840.0 -5438578.78453039 -4.57319023789009 -8.069 -0.9999 3176284 HSCI1_000293 COc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H13 compound treatment 9865560.0 947000.0 0.82 9497680.0 300000.0 0.25 9874120.0 765701.21546961 0.643862571906929 0.9862 0.9232 2195 HSCI1_000294 OS(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc5ccc(c6cc(cc(c56)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c3)ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H14 compound treatment 9383840.0 466000.0 0.4 9634880.0 437000.0 0.36 9982200.0 873781.21546961 0.734744844738404 0.865 0.9483 1714 HSCI1_000295 CN(C)C(=N)NC(=N)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H15 compound treatment 9362600.0 444000.0 0.38 9874160.0 677000.0 0.56 9839240.0 730821.21546961 0.61453268963119 0.8996 0.9822 2197 HSCI1_000296 OS(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc4ccc(cc4S(=O)(=O)O)S(=O)(=O)O)C(=O)Nc5ccc(cc5S(=O)(=O)O)S(=O)(=O)O)cc(c2)C(=O)Nc6ccc(cc6S(=O)(=O)O)S(=O)(=O)O)c(c1)S(=O)(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H16 compound treatment 9665760.0 747000.0 0.64 1.020664E7 1010000.0 0.84 1.03236E7 1215181.21546961 1.02182115806803 1.4447 0.9833 3054849 HSCI1_000297 CCNC(=N)NCCC[C@H](N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H17 mock treatment 9731320.0 813000.0 0.7 1.03344E7 1140000.0 0.94 9923080.0 814661.21546961 0.68503203968847 1.344 0.9886 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H18 mock treatment 9277920.0 360000.0 0.31 1.070296E7 1510000.0 1.25 1.030036E7 1191941.21546961 1.00227911494623 1.4784 0.9064 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H19 mock treatment 9176520.0 258000.0 0.22 9836320.0 639000.0 0.53 9667160.0 558741.21546961 0.469834119046067 0.7055 0.9505 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H20 mock treatment 9326720.0 408000.0 0.35 1.015828E7 961000.0 0.8 9406880.0 298461.21546961 0.250969963119196 0.808 0.8913 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H21 compound treatment 957480.0 -7960000.0 -6.85 1132160.0 -8070000.0 -6.69 1070200.0 -8038218.78453039 -6.75917461745722 -11.721 -1.0 3054896 HSCI1_000298 NC(=O)c1cn(C2OC(CO)[C@H](O)[C@@H]2O)c3ncnc(N)c13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H22 compound treatment 8824240.0 -94100.0 -0.08 8813880.0 -384000.0 -0.32 8302040.0 -806378.78453039 -0.678067512039266 -0.622 -0.8255 2063 HSCI1_000299 CCOC(=O)c1cnc2n(CC)ncc2c1NN=C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H23 compound treatment 8423840.0 -494000.0 -0.43 8878080.0 -319000.0 -0.26 7874400.0 -1234018.78453039 -1.03766128659193 -0.9978 -0.8658 606 HSCI1_000300 CNCCNS(=O)(=O)c1cccc2cnccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 H24 mock treatment 8733560.0 -185000.0 -0.16 9160080.0 -37400.0 -0.03 8486480.0 -621938.78453039 -0.522975668950469 -0.4117 -0.7519 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I01 mock treatment 8391480.0 -527000.0 -0.45 5904200.0 -3290000.0 -2.73 8825880.0 -282538.78453039 -0.237581114925649 -1.9763 -0.711 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I02 compound treatment 9028640.0 110000.0 0.09 7580960.0 -1620000.0 -1.34 8673840.0 -434578.78453039 -0.365428457276661 -0.9304 -0.6678 662 HSCI1_000301 Cc1nc(c(o1)c2ccncc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I03 compound treatment 9245040.0 327000.0 0.28 7015720.0 -2180000.0 -1.81 9707800.0 599381.21546961 0.504007468119634 -0.5916 -0.3114 3054901 HSCI1_000302 Clc1cc(Cl)c(NC(=O)Nc2ccncc2)c(Cl)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I04 compound treatment 9250000.0 332000.0 0.29 7271080.0 -1930000.0 -1.6 8814160.0 -294258.78453039 -0.247436224451786 -0.9007 -0.5485 2110413 HSCI1_000303 Cc1cc(C)c(/C=C/2\C(=O)Nc3ccccc23)[nH]1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I05 mock treatment 8911080.0 -7250.0 -0.01 8501840.0 -696000.0 -0.58 9062120.0 -46298.7845303901 -0.0389317058424923 -0.3593 -0.6211 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I06 mock treatment 9466920.0 549000.0 0.47 9425720.0 228000.0 0.19 1.03332E7 1224781.21546961 1.02989360273107 0.9765 0.8501 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I07 mock treatment 8718800.0 -200000.0 -0.17 9879680.0 682000.0 0.57 9596280.0 487861.21546961 0.4102325692839 0.4644 0.6453 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I08 mock treatment 9249280.0 331000.0 0.28 1.001428E7 817000.0 0.68 9736680.0 628261.21546961 0.528292072480968 0.8607 0.9508 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I09 compound treatment 9246400.0 328000.0 0.28 9610480.0 413000.0 0.34 9648400.0 539981.21546961 0.454059216767028 0.623 0.981 2023 HSCI1_000304 CCCCn1c(=O)n(CCCC)c2ncn(CC(=O)C)c2c1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I10 compound treatment 9566080.0 648000.0 0.56 9534720.0 337000.0 0.28 9522120.0 413701.21546961 0.34787293426186 0.6842 0.958 2196 HSCI1_000305 OS(=O)(=O)c1cc(c2c(NC(=O)c3ccc(NC(=O)c4ccc(NC(=O)Nc5ccc(cc5)C(=O)Nc6ccc(cc6)C(=O)Nc7ccc(c8cc(cc(c78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)cc4)cc3)ccc(c2c1)S(=O)(=O)O)S(=O)(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I11 compound treatment 3504120.0 -5410000.0 -4.66 3624080.0 -5570000.0 -4.62 3838000.0 -5270418.78453039 -4.43178791554238 -7.9184 -0.9998 3054905 HSCI1_000306 Oc1ccc(cc1O)C(=O)/C(=C/c2ccc3oc(=O)[nH]c3c2)/C#N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I12 compound treatment 5572400.0 -3350000.0 -2.88 7605520.0 -1590000.0 -1.32 7850440.0 -1257978.78453039 -1.05780876306345 -3.0358 -0.9089 3054907 HSCI1_000307 Cc1nc2cc3nc(cnc3cc2n1C)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I13 compound treatment 9650080.0 732000.0 0.63 9435640.0 238000.0 0.2 9325280.0 216861.21546961 0.182354183483293 0.5829 0.8513 3479224 HSCI1_000308 CC(=N)NCCCCC(N)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I14 compound treatment 6414720.0 -2500000.0 -2.15 7228680.0 -1970000.0 -1.63 5437760.0 -3670658.78453039 -3.08658228281773 -3.969 -0.9673 2061 HSCI1_000309 Oc1cc(c2cc(ccc2c1N=Nc3ccc4ccccc4c3O)[N+](=O)[O-])S(=O)(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I15 compound treatment 9452040.0 534000.0 0.46 1.038536E7 1190000.0 0.99 9347360.0 238941.21546961 0.200920806208302 0.9501 0.8594 2087 HSCI1_000310 NC(CCC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I16 compound treatment 9298600.0 380000.0 0.33 1.06284E7 1430000.0 1.19 9494480.0 386061.21546961 0.324631020669503 1.0617 0.8338 1870 HSCI1_000311 NC(=N)SCCc1cccc(CCSC(=N)N)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I17 compound treatment 9250480.0 332000.0 0.29 1.050848E7 1310000.0 1.09 9563360.0 454941.21546961 0.382550811126867 1.0138 0.8535 2408 HSCI1_000312 NCCC(O)(P(=O)(O)O)P(=O)(O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I18 compound treatment 9143120.0 225000.0 0.19 1.030688E7 1110000.0 0.92 8571560.0 -536858.78453039 -0.451433628124212 0.3824 0.3666 3054955 HSCI1_000313 Cc1ccc(cc1)S(=O)(=O)N[C@H](CCCCN)C(=O)CCl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I19 mock treatment 9357840.0 440000.0 0.38 1.06166E7 1420000.0 1.18 1.001668E7 908261.21546961 0.763738375153182 1.339 0.9213 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I20 mock treatment 9548400.0 630000.0 0.54 9317600.0 120000.0 0.1 9143040.0 34621.2154696099 0.0291122756297776 0.3874 0.7017 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I21 mock treatment 8918000.0 -325.0 0.0 8786600.0 -411000.0 -0.34 9076480.0 -31938.7845303901 -0.0268566740340173 -0.2125 -0.6214 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I22 mock treatment 9325640.0 407000.0 0.35 9071480.0 -126000.0 -0.1 9106480.0 -1938.78453039005 -0.00163028446199437 0.1411 0.3857 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I23 compound treatment 9873880.0 956000.0 0.82 9752840.0 555000.0 0.46 9019240.0 -89178.7845303901 -0.0749886253374371 0.6975 0.7376 1956 HSCI1_000314 N[C@H](CSCCB(O)O)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 I24 mock treatment 8604560.0 -314000.0 -0.27 9020640.0 -177000.0 -0.15 8835400.0 -273018.78453039 -0.229575940634794 -0.3732 -0.9728 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J01 mock treatment 8627600.0 -291000.0 -0.25 8421320.0 -776000.0 -0.64 8073320.0 -1035098.78453039 -0.870393506136369 -1.0187 -0.9168 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J02 compound treatment 4887480.0 -4030000.0 -3.47 5184720.0 -4010000.0 -3.33 4908280.0 -4200138.78453039 -3.53181124117089 -5.9639 -0.9997 1005830 HSCI1_000315 Cc1cc(ccc1N=Nc2cc(c3ccccc3c2N)S(=O)(=O)O)c4ccc(N=Nc5cc(c6ccccc6c5N)S(=O)(=O)O)c(C)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J03 compound treatment 6376640.0 -2540000.0 -2.19 6303360.0 -2890000.0 -2.4 8862640.0 -245778.78453039 -0.206670378903397 -2.7684 -0.8506 573 HSCI1_000316 CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J04 compound treatment 5208960.0 -3710000.0 -3.19 7058160.0 -2140000.0 -1.77 7433040.0 -1675378.78453039 -1.40879192997553 -3.6812 -0.9403 1038990 HSCI1_000317 FC(F)(F)c1ccc2Sc3ccccc3N(CCCN4CCN(CCCl)CC4)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J05 mock treatment 9274520.0 356000.0 0.31 9425040.0 228000.0 0.19 9557720.0 449301.21546961 0.377808249887327 0.5041 0.966 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J06 mock treatment 9210680.0 292000.0 0.25 9663120.0 466000.0 0.39 9795360.0 686941.21546961 0.577634890483845 0.7018 0.9496 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J07 mock treatment 9521320.0 603000.0 0.52 9463280.0 266000.0 0.22 9660160.0 551741.21546961 0.463947961479261 0.6948 0.9515 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J08 mock treatment 9390960.0 473000.0 0.41 9855400.0 658000.0 0.55 9312920.0 204501.21546961 0.17196091097962 0.6492 0.9247 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J09 compound treatment 8038600.0 -880000.0 -0.76 7395680.0 -1800000.0 -1.49 7236360.0 -1872058.78453039 -1.57417614000971 -2.209 -0.9608 3054961 HSCI1_000318 OCc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J10 compound treatment 7371680.0 -1550000.0 -1.33 5832520.0 -3360000.0 -2.79 4163040.0 -4945378.78453039 -4.15846839332603 -4.7811 -0.9226 1979 HSCI1_000319 Clc1ccc(cc1)C(c2ccc(Cl)cc2)[n+]3ccn(CC(OCc4ccc(Cl)cc4Cl)c5ccc(Cl)cc5Cl)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J11 compound treatment 6981480.0 -1940000.0 -1.67 6911600.0 -2290000.0 -1.9 5240680.0 -3867738.78453039 -3.25230284471287 -3.935 -0.9557 580 HSCI1_000320 Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCN)c4ccccc34)c5ccccc15 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J12 compound treatment 9445360.0 527000.0 0.45 9495200.0 298000.0 0.25 9609880.0 501461.21546961 0.421668532556551 0.6479 0.9718 3054964 HSCI1_000321 CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CCC[C@]2(C)C3C(=O)C[C@@](C)(O[C@]13C)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J13 compound treatment 9140560.0 222000.0 0.19 1.009868E7 901000.0 0.75 9739240.0 630821.21546961 0.530444724391114 0.8483 0.9059 907101 HSCI1_000322 NCCCCNS(=O)(=O)c1ccc2c(Cl)cccc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J14 compound treatment 9604720.0 686000.0 0.59 1.008544E7 888000.0 0.74 9445360.0 336941.21546961 0.283327012143577 0.9299 0.9433 3176334 HSCI1_000323 CC(C)[C@@]1(C)[C@@H]([C@H](OO)c2ccc[nH]2)[C@]3(O)[C@]4(O)[C@@]1(C)[C@@]5(O)C[C@@]3(C)[C@@]6(O)CCC(=C)[C@@H](O)[C@]46O5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J15 compound treatment 6676440.0 -2240000.0 -1.93 5884680.0 -3310000.0 -2.75 6605200.0 -2503218.78453039 -2.10490574141898 -3.9159 -0.9881 3054966 HSCI1_000324 C[C@@H]1CNCCCN1S(=O)(=O)c2cccc3cncc(C)c23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J16 compound treatment 9686800.0 768000.0 0.66 9641640.0 444000.0 0.37 8960280.0 -148138.78453039 -0.124566889642986 0.5227 0.6812 3176335 HSCI1_000325 CN1CCN(CCCC(=O)O[C@H]2[C@@H](O)[C@H]3C(C)(C)CC[C@H](O)[C@]3(C)[C@@]4(O)C(=O)C[C@@](C)(O[C@]24C)C=C)CC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J17 compound treatment 1933840.0 -6980000.0 -6.01 2358000.0 -6840000.0 -5.67 2269720.0 -6838698.78453039 -5.75052265680945 -10.0664 -0.9997 1049343 HSCI1_000326 CCC(C)C1NC(=O)C(NC(=O)c2c(N)c(=O)c(C)c3oc4c(C)ccc(C(=O)NC5C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C6CCCN6C(=O)C(NC5=O)C(C)C)c4nc23)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCN7C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J18 compound treatment 9447080.0 529000.0 0.46 9934760.0 737000.0 0.61 9332040.0 223621.21546961 0.188038529933522 0.7244 0.9226 3054969 HSCI1_000327 C[C@@]12CCC(=O)C=C2CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@@]4(O)C[C@H](O)[C@@H]31 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J19 mock treatment 1.018088E7 1260000.0 1.09 9490000.0 293000.0 0.24 9475680.0 367261.21546961 0.308822483204368 0.9457 0.8185 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J20 mock treatment 9324680.0 406000.0 0.35 9452560.0 255000.0 0.21 8969720.0 -138698.78453039 -0.116628985724323 0.2567 0.604 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J21 mock treatment 8934640.0 16300.0 0.01 9237960.0 40500.0 0.03 9004000.0 -104418.78453039 -0.0878036312400248 -0.0232 -0.2442 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J22 mock treatment 8913280.0 -5050.0 0.0 9612200.0 415000.0 0.34 8925400.0 -183018.78453039 -0.153896771918725 0.1073 0.2846 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J23 compound treatment 8521160.0 -397000.0 -0.34 8451000.0 -746000.0 -0.62 7844000.0 -1264418.78453039 -1.06322402802491 -1.1687 -0.9152 3054970 HSCI1_000328 NC(=NCCSSCCN=C(N)N)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 J24 mock treatment 8632560.0 -286000.0 -0.25 9613680.0 416000.0 0.35 8650400.0 -458018.78453039 -0.385138676328935 -0.165 -0.2881 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K01 mock treatment 8805640.0 -113000.0 -0.1 5661000.0 -3540000.0 -2.93 8328160.0 -780258.78453039 -0.656103735518558 -2.1286 -0.7077 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K02 compound treatment 5048560.0 -3870000.0 -3.33 4249560.0 -4950000.0 -4.1 5038240.0 -4070178.78453039 -3.42253052154488 -6.2687 -0.9955 637 HSCI1_000329 C/C(=C(\C#N)/C(=O)Nc1ccc(OC(F)(F)F)cc1)/O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K03 compound treatment 8161520.0 -757000.0 -0.65 5748640.0 -3450000.0 -2.86 8407800.0 -700618.78453039 -0.589136080001361 -2.368 -0.7912 391 HSCI1_000330 Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K04 compound treatment 240640.0 -8680000.0 -7.47 272160.0 -8930000.0 -7.4 344520.0 -8763898.78453039 -7.3693841636114 -12.8414 -1.0 3055003 HSCI1_000331 O=C1c2ccccc2-[n+]3ccc4c5ccccc5[nH]c4c13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K05 compound treatment 828680.0 -8090000.0 -6.96 1344520.0 -7850000.0 -6.51 3785880.0 -5322538.78453039 -4.47561456302551 -10.3649 -0.984 3055004 HSCI1_000332 Fc1ccc(cc1)C(=O)/C=C/2\C(=O)Nc3ccc(Br)cc23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K06 compound treatment 262840.0 -8660000.0 -7.45 342160.0 -8860000.0 -7.35 298080.0 -8810338.78453039 -7.40843461466889 -12.8194 -1.0 3176336 HSCI1_000333 CC(C)(C)C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c3ccccc32 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K07 mock treatment 8767640.0 -151000.0 -0.13 9106800.0 -90700.0 -0.08 9209360.0 100941.21546961 0.0848794141769963 -0.0693 -0.4023 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K08 mock treatment 9580680.0 662000.0 0.57 9643400.0 446000.0 0.37 9239880.0 131461.21546961 0.110543061168268 0.6065 0.8809 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K09 mock treatment 9135960.0 218000.0 0.19 9624520.0 427000.0 0.35 9274000.0 165581.21546961 0.139233874908182 0.3931 0.9265 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K10 mock treatment 9068520.0 150000.0 0.13 9382720.0 185000.0 0.15 9160920.0 52501.2154696099 0.0441472038147033 0.1888 0.9185 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K11 compound treatment 3068920.0 -5850000.0 -5.03 2711640.0 -6490000.0 -5.38 2994920.0 -6113498.78453039 -5.14071673288842 -8.9809 -0.9996 3055006 HSCI1_000334 COc1cccc(c1)c2cc(NCc3ccc4OCOc4c3)nc(N)n2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K12 compound treatment 8669360.0 -249000.0 -0.21 8748880.0 -449000.0 -0.37 8739080.0 -369338.78453039 -0.310569468754036 -0.5179 -0.9772 3176337 HSCI1_000335 COc1ccc(cc1)c2cnc3c(cnn3c2)c4ccsc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K13 compound treatment 5531800.0 -3390000.0 -2.91 5202840.0 -3990000.0 -3.31 3282880.0 -5825538.78453039 -4.89857702818309 -6.4242 -0.9743 3055009 HSCI1_000336 CC1=C(O)C(=O)[C@H]2O[C@H]2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K14 compound treatment 9807040.0 889000.0 0.76 1.057344E7 1380000.0 1.14 9586440.0 478021.21546961 0.401958313504277 1.3327 0.9309 1709 HSCI1_000337 NCCCC(O)(P(=O)(O)O)P(=O)(O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K15 mock treatment 9514080.0 596000.0 0.51 1.02164E7 1020000.0 0.85 9403080.0 294661.21546961 0.247774620440073 0.9271 0.9096 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K16 mock treatment 9180960.0 263000.0 0.23 1.032208E7 1120000.0 0.93 9798120.0 689701.21546961 0.579955718324471 1.004 0.8952 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K17 compound treatment 7337880.0 -1580000.0 -1.36 8160320.0 -1040000.0 -0.86 7462000.0 -1646418.78453039 -1.384440055242 -2.0814 -0.9804 3176338 HSCI1_000338 CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(=O)(O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K18 compound treatment 9041320.0 123000.0 0.11 9380240.0 183000.0 0.15 9612760.0 504341.21546961 0.424090265955465 0.3935 0.8505 1932 HSCI1_000339 OP(=O)(O)Oc1cccc2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K19 compound treatment 8712800.0 -206000.0 -0.18 9346160.0 149000.0 0.12 8966000.0 -142418.78453039 -0.119757058031254 -0.1001 -0.4057 95 HSCI1_000340 CCCCCC(O)/C=C/C=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K20 compound treatment 8140200.0 -778000.0 -0.67 8153800.0 -1040000.0 -0.87 8483480.0 -624938.78453039 -0.525498307907671 -1.1899 -0.98 3176339 HSCI1_000341 CC(C)[C@@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@@H](O)C[C@H](O)C3=C)\CCC[C@]12C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K21 mock treatment 9047040.0 129000.0 0.11 8947200.0 -250000.0 -0.21 8410800.0 -697618.78453039 -0.586613441044159 -0.3946 -0.6243 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K22 mock treatment 8957440.0 39100.0 0.03 9146400.0 -51100.0 -0.04 9209920.0 101501.21546961 0.0853503067823408 0.0442 0.4377 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K23 mock treatment 9143000.0 225000.0 0.19 8815480.0 -382000.0 -0.32 9062720.0 -45698.7845303901 -0.0384271780510519 -0.0935 -0.2506 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 K24 mock treatment 8659920.0 -258000.0 -0.22 9004360.0 -193000.0 -0.16 8608400.0 -500018.78453039 -0.420455621729767 -0.4637 -0.9238 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L01 mock treatment 8830600.0 -87700.0 -0.08 8807560.0 -390000.0 -0.32 9154000.0 45581.2154696099 0.03832831662009 -0.2082 -0.6227 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L02 compound treatment 8433400.0 -485000.0 -0.42 8406720.0 -791000.0 -0.66 9013480.0 -94938.7845303901 -0.0798320921352655 -0.6658 -0.8518 594 HSCI1_000342 Cc1nc2sccn2c(=O)c1CCN3CCC(=C(c4ccccc4)c5ccc(F)cc5)CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L03 compound treatment 403200.0 -8520000.0 -7.33 374880.0 -8820000.0 -7.32 388160.0 -8720258.78453039 -7.33268817558063 -12.6902 -1.0 581 HSCI1_000343 Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L04 compound treatment 1671600.0 -7250000.0 -6.24 1056080.0 -8140000.0 -6.75 1304480.0 -7803938.78453039 -6.56217333249276 -11.2889 -0.9995 1002019 HSCI1_000344 COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L05 compound treatment 3819600.0 -5100000.0 -4.39 6088640.0 -3110000.0 -2.58 6111600.0 -2996818.78453039 -2.519963937844 -5.4774 -0.9644 3055016 HSCI1_000345 COc1cc2ncnc(N3CCN(CC3)C(=O)Nc4ccc(Oc5ccccc5)cc4)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L06 compound treatment 5065160.0 -3850000.0 -3.32 8563240.0 -634000.0 -0.53 7279240.0 -1829178.78453039 -1.53811922051477 -3.1064 -0.8411 2348 HSCI1_000346 COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)CCC5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L07 mock treatment 9235560.0 317000.0 0.27 9605840.0 408000.0 0.34 1.01352E7 1026781.21546961 0.863399431555721 0.8517 0.8809 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L08 mock treatment 9420480.0 502000.0 0.43 9871280.0 674000.0 0.56 9669120.0 560701.21546961 0.471482243164772 0.8444 0.9941 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L09 mock treatment 9550200.0 632000.0 0.54 9856600.0 659000.0 0.55 9660280.0 551861.21546961 0.464048867037549 0.8976 0.9973 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L10 mock treatment 9332040.0 414000.0 0.36 9564600.0 367000.0 0.3 1.02586E7 1150181.21546961 0.967163980661975 0.9398 0.8745 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L11 compound treatment 6443520.0 -2470000.0 -2.13 6754000.0 -2440000.0 -2.03 5264640.0 -3843778.78453039 -3.23215536824135 -4.2661 -0.9763 582 HSCI1_000347 CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L12 compound treatment 9435960.0 518000.0 0.45 9179800.0 -17700.0 -0.01 1.001896E7 910541.21546961 0.765655580760656 0.6908 0.7797 595 HSCI1_000348 Fc1ccc(cc1)C(=C2CCN(CCn3c(=O)c4ccccc4[nH]c3=S)CC2)c5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L13 compound treatment 8887520.0 -30800.0 -0.03 1.006232E7 865000.0 0.72 9742960.0 634541.21546961 0.533572796698045 0.707 0.7904 3176385 HSCI1_000349 NCC1OC(OC2C(N)CC(N)C(O)C2O[C@@H]3OC[C@H](COCC4OCC(O)C(O)C4N)[C@@H]3O)C(N)C(O)C1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L14 compound treatment 9072280.0 154000.0 0.13 9070200.0 -127000.0 -0.11 9123800.0 15381.2154696099 0.0129337511175869 0.023 0.1353 3055065 HSCI1_000350 Nc1ncn([C@@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L15 mock treatment 9152760.0 234000.0 0.2 9759760.0 562000.0 0.47 9312880.0 204461.21546961 0.171927275793524 0.485 0.9041 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L16 mock treatment 9476960.0 559000.0 0.48 9594920.0 397000.0 0.33 9650600.0 542181.21546961 0.45590915200231 0.7311 0.9879 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L17 compound treatment 9011280.0 93000.0 0.08 8507800.0 -690000.0 -0.57 7385600.0 -1722818.78453039 -1.44868326068542 -1.1205 -0.7185 372 HSCI1_000351 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L18 compound treatment 9547600.0 629000.0 0.54 9580560.0 383000.0 0.32 9911040.0 802621.21546961 0.674907848673565 0.8858 0.9609 1367 HSCI1_000352 Cc1cc(O)ccc1Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L19 compound treatment 8992880.0 74600.0 0.06 8486720.0 -711000.0 -0.59 4393840.0 -4714578.78453039 -3.96439336955194 -2.5922 -0.6467 3055069 HSCI1_000353 CC/C(=C(\c1ccc(O)cc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L20 compound treatment 8810880.0 -107000.0 -0.09 9285640.0 88100.0 0.07 8745840.0 -362578.78453039 -0.304885122303806 -0.1872 -0.5727 2237 HSCI1_000354 FS(=O)(=O)Cc1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L21 mock treatment 8981440.0 63100.0 0.05 9577720.0 380000.0 0.32 8424160.0 -684258.78453039 -0.575379288888084 -0.1187 -0.1803 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L22 mock treatment 8876520.0 -41800.0 -0.04 9419600.0 222000.0 0.18 8793400.0 -315018.78453039 -0.264892886035626 -0.0673 -0.2074 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L23 mock treatment 9251320.0 333000.0 0.29 9361000.0 164000.0 0.14 9107240.0 -1178.78453039005 -9.91215926169788E-4 0.2432 0.767 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 L24 mock treatment 8475360.0 -443000.0 -0.38 9119080.0 -78400.0 -0.07 8815160.0 -293258.78453039 -0.246595344799385 -0.4 -0.8722 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M01 mock treatment 8667720.0 -251000.0 -0.22 5301280.0 -3900000.0 -3.23 8358200.0 -750218.78453039 -0.630843710760439 -2.3548 -0.7135 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M02 compound treatment 8844760.0 -73600.0 -0.06 7472680.0 -1720000.0 -1.43 9339960.0 231541.21546961 0.194698296780536 -0.7503 -0.5191 1900 HSCI1_000355 COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M03 compound treatment 6117800.0 -2800000.0 -2.41 4177640.0 -5020000.0 -4.16 5860920.0 -3247498.78453039 -2.73075564910782 -5.3724 -0.9711 3055072 HSCI1_000356 Cn1cc(/C=C/2\C(=O)Nc3ccc(cc23)S(=O)(=O)N)c4ccccc14 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M04 compound treatment 3043640.0 -5870000.0 -5.06 1769240.0 -7430000.0 -6.16 6534840.0 -2573578.78453039 -2.1640700337619 -7.7263 -0.9354 292 HSCI1_000357 O=C1NCc2c1c3c4ccccc4[nH]c3c5[nH]c6ccccc6c25 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M05 compound treatment 4965080.0 -3950000.0 -3.4 5929880.0 -3270000.0 -2.71 6353200.0 -2755218.78453039 -2.31680741382397 -4.867 -0.9875 907290 HSCI1_000358 CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](O)[C@@]3(C)O[C@](C)(CC(=O)[C@@]32O)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M06 compound treatment 8565560.0 -353000.0 -0.3 9002520.0 -195000.0 -0.16 9146040.0 37621.2154696099 0.0316349145869799 -0.2504 -0.7249 3055076 HSCI1_000359 NS(=O)(=O)c1ccc(N/C=C/2\C(=O)Nc3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M07 compound treatment 7979720.0 -939000.0 -0.81 9191680.0 -5820.0 0.0 8434920.0 -673498.78453039 -0.566331423828252 -0.7961 -0.807 3055122 HSCI1_000360 OC(=O)c1ccc2c3nc4ccccc4n3c(=O)c5cccc1c52 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M08 compound treatment 4038120.0 -4880000.0 -4.2 3900760.0 -5300000.0 -4.39 4012800.0 -5095618.78453039 -4.28480215230272 -7.4356 -0.9998 3176387 HSCI1_000361 Nc1cccc(c1)c2cc3c(Oc4cccc(O)c4)ncnc3[nH]2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M09 mock treatment 8951920.0 33600.0 0.03 1.005252E7 855000.0 0.71 9111120.0 2701.21546960995 0.00227139712514518 0.4275 0.6022 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M10 mock treatment 8988440.0 70100.0 0.06 9131280.0 -66200.0 -0.05 9622720.0 514301.21546961 0.432465427293377 0.2528 0.5744 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M11 mock treatment 9698120.0 780000.0 0.67 9119520.0 -78000.0 -0.06 9718600.0 610181.21546961 0.513088968365562 0.6464 0.7629 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M12 mock treatment 9714080.0 796000.0 0.68 9540280.0 343000.0 0.28 9915320.0 806901.21546961 0.678506813585841 0.9513 0.9465 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M13 mock treatment 8872920.0 -45400.0 -0.04 1.05934E7 1400000.0 1.16 1.011324E7 1004821.21546961 0.844933714389 1.1338 0.7907 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M14 mock treatment 9459880.0 542000.0 0.47 1.053764E7 1340000.0 1.11 1.00534E7 944981.21546961 0.794615475989338 1.3697 0.9487 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M15 compound treatment 8835480.0 -82800.0 -0.07 1.044596E7 1250000.0 1.04 9489840.0 381421.21546961 0.320729339082363 0.742 0.6829 2796 HSCI1_000362 CCCCCCCC/C=C\CCCCCCCC(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M16 compound treatment 2464920.0 -6450000.0 -5.55 3031920.0 -6170000.0 -5.11 2448680.0 -6659738.78453039 -5.60003883421581 -9.3928 -0.9992 3176388 HSCI1_000363 COC(=O)CC(O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@@H]2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M17 compound treatment 8604440.0 -314000.0 -0.27 9916400.0 719000.0 0.6 8755440.0 -352978.78453039 -0.296812677640759 0.017 0.0236 1000076 HSCI1_000364 CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OCC[N+](C)(C)C)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M18 compound treatment 8330480.0 -588000.0 -0.51 8943280.0 -254000.0 -0.21 9084000.0 -24418.7845303901 -0.0205332590479636 -0.4257 -0.7761 2058 HSCI1_000365 OC(=O)C1C(C2CCC1O2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M19 compound treatment 9001080.0 82800.0 0.07 8956040.0 -241000.0 -0.2 8981720.0 -126698.78453039 -0.106538429895514 -0.136 -0.5721 1000072 HSCI1_000366 CC(C)OP(=O)(F)OC(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M20 compound treatment 371120.0 -8550000.0 -7.36 399560.0 -8800000.0 -7.3 306320.0 -8802098.78453039 -7.40150576633311 -12.7341 -1.0 3176389 HSCI1_000367 CC(=O)O[C@@H]1CC2[C@@]3(C)CCCC(C)(C)C3CC[C@@]2(C)C4CC=C(C=O)[C@H](C=O)[C@@]14C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M21 compound treatment 8627680.0 -291000.0 -0.25 8883120.0 -314000.0 -0.26 8859400.0 -249018.78453039 -0.209394828977175 -0.4159 -0.9958 3176390 HSCI1_000368 CCCC(=O)OC1C(OC2COP(O)(O)OC12)n3cnc4c(=O)[nH]c(NOC(=C)CC)nc34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M22 compound treatment 7393480.0 -1520000.0 -1.31 8826240.0 -371000.0 -0.31 7987240.0 -1121178.78453039 -0.942776426615027 -1.4798 -0.8996 3055129 HSCI1_000369 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@@]21C)c5ccc(cc5)N(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M23 mock treatment 8784480.0 -134000.0 -0.12 9261840.0 64300.0 0.05 8826840.0 -281578.78453039 -0.236773870459344 -0.1724 -0.6417 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 M24 mock treatment 8081040.0 -837000.0 -0.72 8925880.0 -272000.0 -0.23 8356360.0 -752058.78453039 -0.632390929320856 -0.9112 -0.9252 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N01 mock treatment 8658320.0 -260000.0 -0.22 8601040.0 -596000.0 -0.49 8607880.0 -500538.78453039 -0.420892879149016 -0.6579 -0.9575 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N02 compound treatment 3371280.0 -5550000.0 -4.77 3200800.0 -6000000.0 -4.97 3612560.0 -5495858.78453039 -4.62135582437961 -8.2965 -0.9995 600 HSCI1_000370 COC(=O)/C=C/c1cc(O)ccc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N03 compound treatment 4343760.0 -4570000.0 -3.94 4051600.0 -5150000.0 -4.27 3765560.0 -5342858.78453039 -4.49270123756229 -7.3316 -0.9985 630 HSCI1_000371 COc1ccc(cc1)S(=O)(=O)N(CCO)c2ccccc2CN(C)C/C=C/c3ccc(Cl)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N04 compound treatment 6422080.0 -2500000.0 -2.15 7568120.0 -1630000.0 -1.35 7878800.0 -1229618.78453039 -1.03396141612137 -2.6177 -0.9551 2283 HSCI1_000372 CCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N05 compound treatment 7638200.0 -1280000.0 -1.1 7817760.0 -1380000.0 -1.14 7921720.0 -1186698.78453039 -0.997870861440325 -1.873 -0.9984 629 HSCI1_000373 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2CN(C)C/C=C/c3ccc(Cl)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N06 compound treatment 9424480.0 506000.0 0.44 9734360.0 537000.0 0.45 9966920.0 858501.21546961 0.72189620364972 0.9254 0.9705 1884 HSCI1_000374 Cc1ccnc(N)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N07 compound treatment 798560.0 -8120000.0 -6.99 4215160.0 -4980000.0 -4.13 3466720.0 -5641698.78453039 -4.74398971288573 -9.1599 -0.9741 1918023 HSCI1_000375 CC[n+]1c(/C=C/N(C)c2ccccc2)n(c3ccccc3)c4ccc(cc14)c5nc6ccccc6s5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N08 compound treatment 9199400.0 281000.0 0.24 9275520.0 78000.0 0.06 9018960.0 -89458.7845303901 -0.0752240716401093 0.1336 0.511 2344 HSCI1_000376 FC(F)(F)C(=O)CC(=O)c1cccs1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N09 mock treatment 9015120.0 96800.0 0.08 8883160.0 -314000.0 -0.26 9611320.0 502901.21546961 0.422879399256008 0.1417 0.2813 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N10 mock treatment 9474280.0 556000.0 0.48 9907920.0 710000.0 0.59 9549360.0 440941.21546961 0.370778495993257 0.8306 0.9831 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N11 mock treatment 9150440.0 232000.0 0.2 8927760.0 -270000.0 -0.22 9803600.0 695181.21546961 0.584563738819627 0.3236 0.4926 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N12 mock treatment 9277000.0 359000.0 0.31 9712080.0 515000.0 0.43 9577440.0 469021.21546961 0.39439039663267 0.6524 0.9914 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N13 mock treatment 9570080.0 652000.0 0.56 9187520.0 -9980.0 -0.01 9517440.0 409021.21546961 0.343937617488624 0.5176 0.7867 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N14 mock treatment 9322360.0 404000.0 0.35 9799440.0 602000.0 0.5 9449320.0 340901.21546961 0.286656895567084 0.6546 0.9731 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N15 compound treatment 2918840.0 -6000000.0 -5.16 5959200.0 -3240000.0 -2.69 5214920.0 -3893498.78453039 -3.27396390455872 -6.4223 -0.9617 1000048 HSCI1_000377 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N16 compound treatment 9114320.0 196000.0 0.17 9270840.0 73300.0 0.06 9043440.0 -64978.7845303901 -0.0546393377493386 0.101 0.5386 2187 HSCI1_000378 O=C(NC1CCCCC1)NC2CCCCC2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N17 compound treatment 9013840.0 95500.0 0.08 8850880.0 -347000.0 -0.29 8917040.0 -191378.78453039 -0.160926525812795 -0.2115 -0.6227 2083 HSCI1_000379 CC(CCC(=O)NCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N18 compound treatment 8774800.0 -144000.0 -0.12 9422520.0 225000.0 0.19 8868840.0 -239578.78453039 -0.201456925058512 -0.0799 -0.2652 1934 HSCI1_000380 NNC(=N)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N19 compound treatment 8829720.0 -88600.0 -0.08 8743560.0 -454000.0 -0.38 9037440.0 -70978.7845303901 -0.0596846156637432 -0.2959 -0.761 30 HSCI1_000381 COC(=O)C1=C(C)NC(=C(C1c2ccccc2C(F)(F)F)[N+](=O)[O-])C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N20 compound treatment 263720.0 -8650000.0 -7.45 304320.0 -8890000.0 -7.38 240560.0 -8867858.78453039 -7.45680201227499 -12.865 -1.0 420 HSCI1_000382 CCN1C(=O)C=CC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N21 compound treatment 8126880.0 -791000.0 -0.68 7957280.0 -1240000.0 -1.03 7756480.0 -1351938.78453039 -1.13681781520303 -1.6436 -0.9797 3054850 HSCI1_000383 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N22 compound treatment 3336000.0 -5580000.0 -4.8 3910040.0 -5290000.0 -4.39 3305320.0 -5803098.78453039 -4.87970768878322 -8.1235 -0.9989 2003 HSCI1_000384 CNC1CCc2cc(OC)c(OC)c(OC)c2-c3ccc(OC)c(=O)cc13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N23 mock treatment 8936800.0 18500.0 0.02 8684040.0 -513000.0 -0.43 9004360.0 -104058.78453039 -0.0875009145651605 -0.2873 -0.6602 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 N24 mock treatment 8011280.0 -907000.0 -0.78 8175840.0 -1020000.0 -0.85 1.136928E7 2260861.21546961 1.90111219299046 0.1576 0.0709 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O01 mock treatment 7969000.0 -949000.0 -0.82 5711880.0 -3490000.0 -2.89 8567440.0 -540978.78453039 -0.454898052292103 -2.4038 -0.791 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O02 mock treatment 8147000.0 -771000.0 -0.66 7476440.0 -1720000.0 -1.43 9358400.0 249981.21546961 0.210204117570806 -1.0862 -0.6838 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O03 compound treatment 3154920.0 -5760000.0 -4.96 2445840.0 -6750000.0 -5.6 3187280.0 -5921138.78453039 -4.9789651229526 -8.9721 -0.9984 3054852 HSCI1_000385 O=C/1Nc2ccc(cc2\C1=C\c3ccc[nH]3)c4cccnc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O04 compound treatment 3046880.0 -5870000.0 -5.05 2713840.0 -6480000.0 -5.38 3355560.0 -5752858.78453039 -4.8374618950466 -8.8157 -0.999 3176393 HSCI1_000386 Cn1nc(N)c2cn(C3OC(CO)C(O)C3O)c4ncnc1c24 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O05 compound treatment 2461800.0 -6460000.0 -5.56 2265360.0 -6930000.0 -5.75 2289600.0 -6818818.78453039 -5.73380596931972 -9.8388 -0.9999 3176394 HSCI1_000387 C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5[nH]cnc25 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O06 compound treatment 7075440.0 -1840000.0 -1.59 7345560.0 -1850000.0 -1.54 7967600.0 -1140818.78453039 -0.959291302988178 -2.3565 -0.9788 575 HSCI1_000388 O=C1NC(=O)C(=C1c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O07 compound treatment 4459000.0 -4460000.0 -3.84 4849960.0 -4350000.0 -3.61 4715520.0 -4392898.78453039 -3.69389920296766 -6.4307 -0.9997 3176395 HSCI1_000389 CCCCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@@H](N2C1=O)c5ccc(OC)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O08 compound treatment 8369600.0 -549000.0 -0.47 7842920.0 -1350000.0 -1.12 8184760.0 -923658.78453039 -0.776685877672828 -1.3699 -0.9478 2116778 HSCI1_000390 CCOC(=O)c1cnc2oc3ccc(O)cc3c2c1c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O09 compound treatment 2568160.0 -6350000.0 -5.47 2377840.0 -6820000.0 -5.66 2523960.0 -6584458.78453039 -5.53673741398308 -9.6183 -0.9999 3176396 HSCI1_000391 CC(C)[C@H](CO)Nc1nc(Nc2cc(N)cc(Cl)c2)c3ncn(C(C)C)c3n1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O10 compound treatment 6812720.0 -2110000.0 -1.81 6803360.0 -2390000.0 -1.99 8160760.0 -947658.78453039 -0.796866989330446 -2.653 -0.9461 676 HSCI1_000392 COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O11 mock treatment 1.000728E7 1090000.0 0.94 9264720.0 67200.0 0.06 9782440.0 674021.21546961 0.566770725374827 0.9005 0.8211 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O12 mock treatment 1.01256E7 1210000.0 1.04 9354440.0 157000.0 0.13 9945560.0 837141.21546961 0.70393501427444 1.0815 0.8571 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O13 mock treatment 9412480.0 494000.0 0.43 9639480.0 442000.0 0.37 9234440.0 126021.21546961 0.105968675859208 0.5184 0.9072 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O14 mock treatment 9884600.0 966000.0 0.83 1.092544E7 1730000.0 1.43 1.008544E7 977021.21546961 0.821557260052259 1.7821 0.9634 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O15 compound treatment 9452040.0 534000.0 0.46 1.026296E7 1070000.0 0.88 9630960.0 522541.21546961 0.439394275629159 1.0292 0.9453 1398 HSCI1_000393 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OC(=O)C)c(C)c(C)c2O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O16 compound treatment 7741040.0 -1180000.0 -1.01 8594720.0 -603000.0 -0.5 8349800.0 -758618.78453039 -0.637907099840605 -1.242 -0.9572 2060355 HSCI1_000394 CC1=C(C=C)/C(=C/c2[nH]c(Cc3[nH]c(\C=C\4/NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)/NC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O17 compound treatment 9073200.0 155000.0 0.13 9894680.0 697000.0 0.58 9493720.0 385301.21546961 0.323991952133678 0.5979 0.8843 1929 HSCI1_000395 Nc1cccc2c(=O)[nH]ccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O18 compound treatment 8953480.0 35200.0 0.03 9276520.0 79000.0 0.07 9421640.0 313221.21546961 0.263381346788631 0.2074 0.7594 2286 HSCI1_000396 CCSC(=N)N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O19 compound treatment 9914200.0 996000.0 0.86 9024720.0 -173000.0 -0.14 9367240.0 258821.21546961 0.217637493698029 0.5377 0.6003 23 HSCI1_000397 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O20 compound treatment 664920.0 -8250000.0 -7.1 1140560.0 -8060000.0 -6.68 755760.0 -8352658.78453039 -7.02358081535811 -12.015 -0.9997 3054913 HSCI1_000398 Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc2ccccc2)C(=O)CCl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O21 compound treatment 7395440.0 -1520000.0 -1.31 7922640.0 -1270000.0 -1.06 7485320.0 -1623098.78453039 -1.36483074174802 -2.1553 -0.9943 3176397 HSCI1_000399 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(=C/C=C/3\C[C@@H](O)C[C@H](O)C3=C)/CCC[C@@]12C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O22 compound treatment 8588560.0 -330000.0 -0.28 9225920.0 28400.0 0.02 8657040.0 -451378.78453039 -0.379555235436994 -0.3694 -0.7784 988 HSCI1_000400 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O23 mock treatment 9108800.0 190000.0 0.16 9411720.0 214000.0 0.18 8603200.0 -505218.78453039 -0.424828195922251 -0.048 -0.0983 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 O24 mock treatment 8060200.0 -858000.0 -0.74 8362520.0 -835000.0 -0.69 7785280.0 -1323138.78453039 -1.11260048121389 -1.4687 -0.9763 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P01 mock treatment 7475880.0 -1440000.0 -1.24 7345120.0 -1850000.0 -1.54 7486800.0 -1621618.78453039 -1.36358623986247 -2.3912 -0.9962 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P02 mock treatment 8055040.0 -863000.0 -0.74 8528160.0 -669000.0 -0.56 8748800.0 -359618.78453039 -0.3023961185327 -0.9241 -0.9473 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P03 mock treatment 8656400.0 -262000.0 -0.23 8402680.0 -795000.0 -0.66 8186960.0 -921458.78453039 -0.774835942437546 -0.9582 -0.9195 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P04 mock treatment 8315120.0 -603000.0 -0.52 8668440.0 -529000.0 -0.44 8723680.0 -384738.78453039 -0.323519015401007 -0.7399 -0.9828 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P05 mock treatment 8094600.0 -824000.0 -0.71 8975360.0 -222000.0 -0.18 8749400.0 -359018.78453039 -0.30189159074126 -0.69 -0.8709 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P06 mock treatment 8237280.0 -681000.0 -0.59 8601160.0 -596000.0 -0.49 8525520.0 -582898.78453039 -0.490147727320743 -0.907 -0.9965 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P07 mock treatment 8572280.0 -346000.0 -0.3 8649680.0 -548000.0 -0.45 8563000.0 -545418.78453039 -0.458631557948762 -0.6991 -0.9832 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P08 mock treatment 8185480.0 -733000.0 -0.63 8828760.0 -369000.0 -0.31 9482480.0 374061.21546961 0.314540464840693 -0.3592 -0.4675 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P09 mock treatment 8627760.0 -291000.0 -0.25 8102480.0 -1100000.0 -0.91 8932440.0 -175978.78453039 -0.147976979165824 -0.7543 -0.7909 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P10 mock treatment 8518880.0 -399000.0 -0.34 8528720.0 -669000.0 -0.55 8500680.0 -607738.78453039 -0.511035177886378 -0.8138 -0.9818 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P11 mock treatment 8593920.0 -324000.0 -0.28 8758120.0 -439000.0 -0.36 8962920.0 -145498.78453039 -0.122346967360648 -0.4423 -0.9308 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P12 mock treatment 8465640.0 -453000.0 -0.39 8793480.0 -404000.0 -0.34 8900560.0 -207858.78453039 -0.17478422248436 -0.5194 -0.9567 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P13 mock treatment 8303840.0 -614000.0 -0.53 8115200.0 -1080000.0 -0.9 8791120.0 -317298.78453039 -0.2668100916431 -0.9777 -0.909 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P14 mock treatment 8379640.0 -539000.0 -0.46 1.0691E7 1490000.0 1.24 8622520.0 -485898.78453039 -0.408582401037869 0.2118 0.1529 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P15 mock treatment 8441640.0 -477000.0 -0.41 8722120.0 -475000.0 -0.39 9031280.0 -77138.7845303901 -0.0648644343225319 -0.502 -0.8765 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P16 mock treatment 8332080.0 -586000.0 -0.5 1.186352E7 2670000.0 2.21 8373280.0 -735138.78453039 -0.618163245602235 0.6287 0.2674 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P17 mock treatment 7777040.0 -1140000.0 -0.98 8830720.0 -367000.0 -0.3 8438960.0 -669458.78453039 -0.562934270032553 -1.0678 -0.9108 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P18 mock treatment 8658720.0 -260000.0 -0.22 8383240.0 -814000.0 -0.68 8545960.0 -562458.78453039 -0.472960147225671 -0.792 -0.9271 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P19 mock treatment 7778520.0 -1140000.0 -0.98 7831440.0 -1370000.0 -1.13 8240120.0 -868298.78453039 -0.730134780115921 -1.6422 -0.985 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P20 mock treatment 7772400.0 -1150000.0 -0.99 8377640.0 -820000.0 -0.68 7753680.0 -1354738.78453039 -1.13917227822975 -1.6198 -0.9798 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P21 mock treatment 8205760.0 -713000.0 -0.61 7816920.0 -1380000.0 -1.15 7959560.0 -1148858.78453039 -0.96605197539348 -1.573 -0.9716 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P22 mock treatment 7898840.0 -1020000.0 -0.88 8176320.0 -1020000.0 -0.85 8163040.0 -945378.78453039 -0.794949783722972 -1.4546 -0.9992 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P23 mock treatment 7803360.0 -1110000.0 -0.96 8083560.0 -1110000.0 -0.92 7718920.0 -1389498.78453039 -1.1684012549472 -1.7621 -0.9944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2105 P24 mock treatment 7053920.0 -1860000.0 -1.6 7140400.0 -2060000.0 -1.71 7243360.0 -1865058.78453039 -1.56828998244291 -2.8171 -0.9994 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A01 compound treatment 6618600.0 -3260000.0 -2.81 6438200.0 -3660000.0 -3.04 6929040.0 -3001616.77419355 -2.52399846972418 -4.8316 -0.9972 3220649 PK04_107001 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A02 compound treatment 7576320.0 -2300000.0 -1.98 7388000.0 -2710000.0 -2.25 7601200.0 -2329456.77419355 -1.95879280256648 -3.5745 -0.9979 3188507 PK04_107002 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(o3)c4ccc(Cl)c(Cl)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A03 compound treatment 8436880.0 -1440000.0 -1.24 8234920.0 -1870000.0 -1.55 7255600.0 -2675056.77419355 -2.24940081043618 -2.909 -0.9698 3220651 PK04_107003 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4cncn4C)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A04 compound treatment 8045800.0 -1830000.0 -1.58 7657200.0 -2450000.0 -2.03 7617040.0 -2313616.77419355 -1.94547326887245 -3.2046 -0.9944 3070126 PK04_107004 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A05 compound treatment 8669480.0 -1210000.0 -1.04 8411680.0 -1690000.0 -1.4 8234840.0 -1695816.77419355 -1.42597781961926 -2.2334 -0.9907 3220653 PK04_107005 CCCCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A06 compound treatment 8378360.0 -1500000.0 -1.29 9009640.0 -1090000.0 -0.91 7727120.0 -2203536.77419355 -1.85290923673618 -2.3381 -0.961 3070127 PK04_107006 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A07 compound treatment 8587840.0 -1290000.0 -1.11 9234600.0 -868000.0 -0.72 8255760.0 -1674896.77419355 -1.40838661729103 -1.8697 -0.9675 3220655 PK04_107007 CCOC(=O)c1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A08 compound treatment 8285040.0 -1590000.0 -1.37 8228280.0 -1870000.0 -1.55 7711120.0 -2219536.77419355 -1.86636331117459 -2.7665 -0.9919 3070128 PK04_107008 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3CO[Si](C(C)C)(C(C)C)c31 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A09 compound treatment 8489040.0 -1390000.0 -1.2 8742840.0 -1360000.0 -1.13 8273720.0 -1656936.77419355 -1.39328441873392 -2.1456 -0.9959 3220657 PK04_107009 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)c3ccccn3)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A10 compound treatment 8582600.0 -1300000.0 -1.11 8886800.0 -1220000.0 -1.01 9003840.0 -926816.77419355 -0.77934136692307 -1.6757 -0.9897 3070129 PK04_107010 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C3CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A11 compound treatment 8582240.0 -1300000.0 -1.12 9220200.0 -882000.0 -0.73 8342400.0 -1588256.77419355 -1.33553280420703 -1.8373 -0.9734 3220659 PK04_107011 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCCC3)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A12 compound treatment 7757920.0 -2120000.0 -1.82 8453000.0 -1650000.0 -1.37 7913640.0 -2017016.77419355 -1.69606836397038 -2.8225 -0.9931 3188513 PK04_107012 CCCCCCc1nc(CCCc2cc3CO[Si](C(C)C)(C(C)C)c3c(CCCCCC)n2)cc4CO[Si](C(C)C)(C(C)C)c41 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A13 mock treatment 9135160.0 -743000.0 -0.64 9462040.0 -640000.0 -0.53 8440600.0 -1490056.77419355 -1.25295842234128 -1.399 -0.9305 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A14 mock treatment 8904320.0 -974000.0 -0.84 9123160.0 -979000.0 -0.81 8416520.0 -1514136.77419355 -1.27320680437109 -1.6877 -0.9772 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A15 compound treatment 8383320.0 -1490000.0 -1.29 9144320.0 -958000.0 -0.79 8468440.0 -1462216.77419355 -1.22954833281844 -1.9113 -0.9808 3220661 PK04_107013 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A16 compound treatment 8619000.0 -1260000.0 -1.08 9006200.0 -1100000.0 -0.91 8800200.0 -1130456.77419355 -0.950578099337962 -1.6993 -0.9971 3188514 PK04_107014 CCCCCCc1nc(c2ccc(o2)c3ccc(Cl)c(Cl)c3)c(C)c4CO[Si](C(C)C)(C(C)C)c41 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A17 compound treatment 9074640.0 -803000.0 -0.69 8867520.0 -1230000.0 -1.02 9446560.0 -484096.77419355 -0.407067127212204 -1.2255 -0.9419 3220663 PK04_107015 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)c3ccccc3C)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A18 compound treatment 8045600.0 -1830000.0 -1.58 8903560.0 -1200000.0 -0.99 9050040.0 -880616.77419355 -0.740492726982155 -1.912 -0.9532 3070178 PK04_107016 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A19 compound treatment 8882640.0 -995000.0 -0.86 8749800.0 -1350000.0 -1.12 9182840.0 -747816.77419355 -0.628823909143333 -1.5053 -0.9742 3220665 PK04_107017 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(Cc3ccccc3)nn2)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A20 compound treatment 8157560.0 -1720000.0 -1.48 8508400.0 -1590000.0 -1.32 7838840.0 -2091816.77419355 -1.75896616196996 -2.6337 -0.993 3070179 PK04_107018 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A21 compound treatment 8523520.0 -1350000.0 -1.17 8805240.0 -1300000.0 -1.08 8083760.0 -1846896.77419355 -1.55301791750397 -2.1908 -0.9869 3220667 PK04_107019 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)C3(O)CCCCC3)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A22 compound treatment 7382080.0 -2500000.0 -2.15 8035240.0 -2070000.0 -1.71 9285360.0 -645296.77419355 -0.542616927179207 -2.5434 -0.9079 3070180 PK04_107020 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A23 compound treatment 7137720.0 -2740000.0 -2.36 7630560.0 -2470000.0 -2.05 7414440.0 -2516216.77419355 -2.11583548644885 -3.7669 -0.9982 3220669 PK04_107021 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)c3cncn3C)C(C)C)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 A24 compound treatment 5314840.0 -4560000.0 -3.93 6005080.0 -4100000.0 -3.4 5886680.0 -4043976.77419355 -3.40049778420064 -6.1929 -0.9976 3070181 PK04_107022 CCCCCCc1nc(C2CC2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B01 compound treatment 8113200.0 -1760000.0 -1.52 8924560.0 -1180000.0 -0.98 8401080.0 -1529576.77419355 -1.28618998620416 -2.1835 -0.9849 3188518 PK04_107023 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B02 compound treatment 8747080.0 -1130000.0 -0.97 8523200.0 -1580000.0 -1.31 8634680.0 -1295976.77419355 -1.08976049940334 -1.9473 -0.9924 3188519 PK04_107024 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B03 compound treatment 9416040.0 -462000.0 -0.4 8875440.0 -1230000.0 -1.02 9048400.0 -882256.77419355 -0.741871769612092 -1.2454 -0.943 3070182 PK04_107025 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B04 compound treatment 9914440.0 36600.0 0.03 9493720.0 -609000.0 -0.5 9412920.0 -517736.77419355 -0.435354318718965 -0.5246 -0.7861 3188520 PK04_107026 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B05 compound treatment 9577600.0 -300000.0 -0.26 9114080.0 -988000.0 -0.82 8889320.0 -1041336.77419355 -0.875638904716006 -1.128 -0.9193 3188521 PK04_107027 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B06 compound treatment 9860040.0 -17800.0 -0.02 9405320.0 -697000.0 -0.58 8666160.0 -1264496.77419355 -1.06328960794576 -0.9565 -0.7903 3070183 PK04_107028 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B07 compound treatment 9729680.0 -148000.0 -0.13 9163480.0 -939000.0 -0.78 9132240.0 -798416.77419355 -0.671372419554812 -0.9108 -0.8791 3188640 PK04_107029 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B08 compound treatment 9787360.0 -90500.0 -0.08 9715440.0 -387000.0 -0.32 9486080.0 -444576.77419355 -0.373835563349325 -0.446 -0.8943 3188641 PK04_107030 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B09 compound treatment 9926760.0 48900.0 0.04 9491720.0 -611000.0 -0.51 9347400.0 -583256.77419355 -0.490448753544263 -0.5513 -0.7805 3070184 PK04_107031 COc1ccc(CC(=O)N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B10 compound treatment 1.011136E7 234000.0 0.2 1.01718E7 69600.0 0.06 9797520.0 -133136.77419355 -0.111952004405631 0.0847 0.3572 3188642 PK04_107032 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B11 compound treatment 9253360.0 -624000.0 -0.54 1.010992E7 7700.0 0.01 9040720.0 -889936.77419355 -0.74832972534253 -0.7387 -0.8017 3070185 PK04_107033 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B12 compound treatment 9981400.0 104000.0 0.09 1.066892E7 567000.0 0.47 9288280.0 -642376.77419355 -0.540161558594197 0.011 0.0153 3188643 PK04_107034 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B13 mock treatment 1.010284E7 225000.0 0.19 9847200.0 -255000.0 -0.21 9631720.0 -298936.77419355 -0.251369850773678 -0.1555 -0.4077 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B14 mock treatment 1.0216E7 338000.0 0.29 1.004084E7 -61400.0 -0.05 9920720.0 -9936.77419354953 -0.00835563122985682 0.1338 0.4527 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B15 compound treatment 9851160.0 -26700.0 -0.02 9805720.0 -297000.0 -0.25 1.014596E7 215303.22580645 0.181044101676892 -0.0507 -0.1657 3188644 PK04_107035 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B16 compound treatment 1.01804E7 303000.0 0.26 1.009656E7 -5660.0 0.0 1.022176E7 291103.22580645 0.24478277932887 0.289 0.8084 3070186 PK04_107036 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B17 compound treatment 9733480.0 -144000.0 -0.12 9858440.0 -244000.0 -0.2 1.006576E7 135103.22580645 0.11360555355435 -0.1229 -0.4671 3188645 PK04_107037 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B18 compound treatment 1.014812E7 270000.0 0.23 1.007892E7 -23300.0 -0.02 9893480.0 -37176.7741935495 -0.0312611929612537 0.1051 0.4462 3188646 PK04_107038 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B19 compound treatment 1.023952E7 362000.0 0.31 9738840.0 -363000.0 -0.3 9710480.0 -220176.77419355 -0.185142169350594 -0.1012 -0.2148 3070187 PK04_107039 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B20 compound treatment 1.002844E7 151000.0 0.13 1.046012E7 358000.0 0.3 1.00144E7 83743.2258064505 0.0704179746070469 0.2869 0.8654 3188647 PK04_107040 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B21 compound treatment 1.000084E7 123000.0 0.11 9586680.0 -516000.0 -0.43 8901520.0 -1029136.77419355 -0.865380172956717 -0.6854 -0.7058 3188648 PK04_107041 COc1ccc(CC(=O)N(Cc2cc3ccccc3o2)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B22 compound treatment 1.001388E7 136000.0 0.12 9851280.0 -251000.0 -0.21 9109120.0 -821536.77419355 -0.690813557118318 -0.4514 -0.6176 3070188 PK04_107042 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B23 compound treatment 8639760.0 -1240000.0 -1.07 8726520.0 -1380000.0 -1.14 8313240.0 -1617416.77419355 -1.36005285487104 -2.0593 -0.9945 3188649 PK04_107043 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 B24 compound treatment 7062240.0 -2820000.0 -2.42 8971360.0 -1130000.0 -0.94 9135480.0 -795176.77419355 -0.668647969481034 -2.3267 -0.8672 3188650 PK04_107044 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C01 compound treatment 8318120.0 -1560000.0 -1.34 8157880.0 -1940000.0 -1.61 8304440.0 -1626216.77419355 -1.36745259581217 -2.4958 -0.9964 3414054 PK04_107045 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C02 compound treatment 8880160.0 -998000.0 -0.86 9468640.0 -634000.0 -0.53 8788960.0 -1141696.77419355 -0.960029586630947 -1.3535 -0.9729 3188651 PK04_107046 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C03 compound treatment 9601800.0 -276000.0 -0.24 9146840.0 -955000.0 -0.79 9248840.0 -681816.77419355 -0.573325852084883 -0.9258 -0.9197 3414055 PK04_107047 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(Cc4ccccc4)nn3)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C04 compound treatment 9582840.0 -295000.0 -0.25 9901320.0 -201000.0 -0.17 9594960.0 -335696.77419355 -0.28228058679593 -0.4058 -0.9787 3070235 PK04_107048 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4cc(C)c(OC)c(C)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C05 compound treatment 1.006516E7 187000.0 0.16 9882160.0 -220000.0 -0.18 9460240.0 -470416.77419355 -0.395563893567361 -0.2407 -0.5182 3414056 PK04_107049 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C06 compound treatment 9881080.0 3250.0 0.0 9525480.0 -577000.0 -0.48 9753800.0 -176856.77419355 -0.148715262808593 -0.3605 -0.7195 3070236 PK04_107050 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(OC)nc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C07 compound treatment 9985080.0 107000.0 0.09 9938800.0 -163000.0 -0.14 9695560.0 -235096.77419355 -0.197688093764413 -0.1391 -0.5416 3414057 PK04_107051 CCCCc1cn(C[C@@H]2CCCN2C(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C08 compound treatment 9846480.0 -31400.0 -0.03 9780440.0 -322000.0 -0.27 9331560.0 -599096.77419355 -0.503768287238292 -0.4605 -0.8069 3188655 PK04_107052 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3[C@@H](O[Si](C(C)C)(C(C)C)c31)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C09 compound treatment 1.003236E7 155000.0 0.13 9875440.0 -227000.0 -0.19 9715000.0 -215656.77419355 -0.181341393321742 -0.1365 -0.4657 3220705 PK04_107053 CCc1oc(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCCC3)c(C(=O)OC)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C10 compound treatment 9943600.0 65800.0 0.06 9707640.0 -395000.0 -0.33 9660920.0 -269736.77419355 -0.226816164923576 -0.2873 -0.7142 3188656 PK04_107054 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C11 mock treatment 9933360.0 55500.0 0.05 1.016388E7 61700.0 0.05 1.01696E7 238943.22580645 0.200922496659646 0.1731 0.8137 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C12 mock treatment 9754800.0 -123000.0 -0.11 1.056444E7 462000.0 0.38 1.012188E7 191223.22580645 0.160795719647081 0.2531 0.5898 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C13 compound treatment 1.005152E7 174000.0 0.15 1.050892E7 407000.0 0.34 1.00906E7 159943.22580645 0.134493004119985 0.3587 0.9134 3220708 PK04_107055 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C14 compound treatment 9916120.0 38300.0 0.03 1.033968E7 237000.0 0.2 1.0109E7 178343.22580645 0.149965189724159 0.2193 0.8782 3188772 PK04_107056 CCCCCCc1nc(CCCc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCCCCC)n2)c4ccccc4)cc5[C@@H](O[Si](C(C)C)(C(C)C)c51)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C15 mock treatment 9912080.0 34200.0 0.03 9574680.0 -528000.0 -0.44 1.001924E7 88583.2258064505 0.0744878321246666 -0.1926 -0.433 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C16 mock treatment 9730440.0 -147000.0 -0.13 9703200.0 -399000.0 -0.33 1.029596E7 365303.22580645 0.307176049537006 -0.087 -0.1855 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C17 compound treatment 1.0285E7 407000.0 0.35 1.097644E7 874000.0 0.73 1.034644E7 415783.22580645 0.349623654390197 0.8229 0.9372 3220711 PK04_107057 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C18 compound treatment 1.050276E7 625000.0 0.54 1.028944E7 187000.0 0.16 9890200.0 -40456.7741935495 -0.0340192782211282 0.3805 0.6785 3070242 PK04_107058 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C19 compound treatment 1.019836E7 321000.0 0.28 9876200.0 -226000.0 -0.19 1.062676E7 696103.22580645 0.585339038551179 0.389 0.5773 3220713 PK04_107059 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4N)oc(C(=O)C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C20 compound treatment 1.02444E7 367000.0 0.32 9916560.0 -186000.0 -0.15 9706160.0 -224496.77419355 -0.188774769448965 -0.0158 -0.0396 3070245 PK04_107060 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C21 compound treatment 9421760.0 -456000.0 -0.39 9495560.0 -607000.0 -0.5 9836360.0 -94296.7741935495 -0.0792922387063854 -0.563 -0.8753 3220715 PK04_107061 COC(=O)c1cn(C[C@@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C22 compound treatment 9505160.0 -373000.0 -0.32 9468720.0 -634000.0 -0.53 9504440.0 -426216.77419355 -0.358397012931247 -0.6955 -0.9763 3070527 PK04_107062 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)cc(OC)c1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C23 compound treatment 9294320.0 -584000.0 -0.5 9161640.0 -941000.0 -0.78 9586760.0 -343896.77419355 -0.289175799945616 -0.9074 -0.9336 3220717 PK04_107063 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 C24 compound treatment 7626720.0 -2250000.0 -1.94 8381920.0 -1720000.0 -1.43 7876680.0 -2053976.77419355 -1.72714727592312 -2.9397 -0.9925 3070530 PK04_107064 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)C4CC4)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D01 compound treatment 9052120.0 -826000.0 -0.71 9241040.0 -861000.0 -0.71 8290120.0 -1640536.77419355 -1.37949399243454 -1.6192 -0.9478 3188777 PK04_107065 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D02 compound treatment 9743880.0 -134000.0 -0.12 9847480.0 -255000.0 -0.21 9460760.0 -469896.77419355 -0.395126636148113 -0.4167 -0.9006 3188778 PK04_107066 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D03 compound treatment 9310560.0 -567000.0 -0.49 9805920.0 -296000.0 -0.25 9628520.0 -302136.77419355 -0.25406066566136 -0.5705 -0.9464 3070575 PK04_107067 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D04 compound treatment 1.04118E7 534000.0 0.46 9803160.0 -299000.0 -0.25 9835040.0 -95616.7741935495 -0.0804021998475544 0.0757 0.1432 3188779 PK04_107068 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D05 compound treatment 9601400.0 -276000.0 -0.24 1.019872E7 96500.0 0.08 9621560.0 -309096.77419355 -0.25991318804207 -0.2412 -0.6675 3188780 PK04_107069 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D06 compound treatment 1.00126E7 135000.0 0.12 1.010228E7 58.1 0.0 9750040.0 -180616.77419355 -0.151876970301619 -0.0207 -0.1083 3070579 PK04_107070 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D07 compound treatment 9647600.0 -230000.0 -0.2 1.029572E7 193000.0 0.16 1.014384E7 213183.22580645 0.179261436813802 0.0818 0.2623 3188781 PK04_107071 COc1ccc(CC(=O)N(Cc2cccc3ccccc23)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D08 compound treatment 9904880.0 27000.0 0.02 9802360.0 -300000.0 -0.25 1.078108E7 850423.22580645 0.715103586509666 0.2827 0.3732 3188782 PK04_107072 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D09 compound treatment 1.005284E7 175000.0 0.15 1.02958E7 194000.0 0.16 1.023512E7 304463.22580645 0.256016931484944 0.3275 0.9698 3188783 PK04_107073 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc(OC)cc5)c6ccc(OCCCO)cc46)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D10 compound treatment 1.061608E7 738000.0 0.64 1.017984E7 77600.0 0.06 1.060132E7 670663.22580645 0.563947060194104 0.7296 0.8564 3070632 PK04_107074 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5cccc6ccccc56)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D11 mock treatment 1.004444E7 167000.0 0.14 1.015608E7 53900.0 0.04 9983680.0 53023.2258064505 0.0445861516852954 0.1343 0.8574 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D12 mock treatment 1.085312E7 975000.0 0.84 1.03326E7 230000.0 0.19 1.084088E7 910223.22580645 0.765388189723231 1.0368 0.9001 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D13 compound treatment 9833920.0 -43900.0 -0.04 1.074784E7 646000.0 0.54 1.030312E7 372463.22580645 0.313196747848196 0.4682 0.7533 3188784 PK04_107075 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D14 compound treatment 1.07904E7 913000.0 0.79 1.118056E7 1080000.0 0.89 1.089124E7 960583.22580645 0.807734889018134 1.4363 0.9984 3188785 PK04_107076 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D15 mock treatment 1.007876E7 201000.0 0.17 1.042064E7 318000.0 0.26 1.052176E7 591103.22580645 0.497046675049099 0.5393 0.9159 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D16 mock treatment 1.087412E7 996000.0 0.86 1.03288E7 227000.0 0.19 1.09372E7 1006543.22580645 0.846381717842473 1.0922 0.8957 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D17 compound treatment 1.0359E7 481000.0 0.41 1.078808E7 686000.0 0.57 1.089616E7 965503.22580645 0.811872016907946 1.0363 0.9645 3070637 PK04_107077 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)Cc5ccc6ccccc6c5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D18 compound treatment 1.052232E7 644000.0 0.55 1.03304E7 228000.0 0.19 1.06548E7 724143.22580645 0.608917304004497 0.7811 0.9242 3188786 PK04_107078 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D19 compound treatment 1.098908E7 1110000.0 0.96 1.042096E7 319000.0 0.26 1.079364E7 862983.22580645 0.725665034943819 1.1238 0.9142 3188787 PK04_107079 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc6ccccc6n5)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D20 compound treatment 1.00952E7 217000.0 0.19 1.080108E7 699000.0 0.58 1.109276E7 1162103.22580645 0.977188956569936 1.0069 0.8744 3070641 PK04_107080 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D21 compound treatment 1.02406E7 363000.0 0.31 1.028452E7 182000.0 0.15 1.011544E7 184783.22580645 0.15538045468562 0.3573 0.9399 3188905 PK04_107081 COc1ccc(CC(=O)N(Cc2ccc(cc2)c3ccccc3)[C@@H]4[C@@H](C(CC=C)OC(=O)C)N(C(=O)c5ccc(cc5)c6ccccc6)c7ccc(OCCCO)cc47)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D22 compound treatment 1.08282E7 950000.0 0.82 9909320.0 -193000.0 -0.16 9279520.0 -651136.77419355 -0.547527664349227 0.0637 0.0639 3188906 PK04_107082 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4cccc5ccccc45)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D23 compound treatment 9515720.0 -362000.0 -0.31 9962440.0 -140000.0 -0.12 9377200.0 -553456.77419355 -0.465390539902721 -0.5156 -0.9014 3070684 PK04_107083 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 D24 compound treatment 8662200.0 -1220000.0 -1.05 8430800.0 -1670000.0 -1.39 8258640.0 -1672016.77419355 -1.40596488389212 -2.2163 -0.9918 3188907 PK04_107084 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E01 mock treatment 8614400.0 -1260000.0 -1.09 9168200.0 -934000.0 -0.77 8621680.0 -1308976.77419355 -1.10069193488455 -1.7106 -0.9886 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E02 mock treatment 9282080.0 -596000.0 -0.51 9552080.0 -550000.0 -0.46 9394800.0 -535856.77419355 -0.450591058020467 -0.8197 -0.9983 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E03 compound treatment 9252160.0 -626000.0 -0.54 9622920.0 -479000.0 -0.4 9426160.0 -504496.77419355 -0.424221072121179 -0.7854 -0.991 3220739 PK04_107085 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E04 compound treatment 9299080.0 -579000.0 -0.5 9929240.0 -173000.0 -0.14 9755240.0 -175416.77419355 -0.147504396109135 -0.4556 -0.8453 3070690 PK04_107086 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C(=C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E05 compound treatment 9372560.0 -505000.0 -0.43 9891960.0 -210000.0 -0.17 9763240.0 -167416.77419355 -0.140777358889929 -0.433 -0.8852 3220741 PK04_107087 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCC4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E06 compound treatment 8628320.0 -1250000.0 -1.08 9552640.0 -550000.0 -0.46 9040320.0 -890336.77419355 -0.74866607720349 -1.3163 -0.9488 3070694 PK04_107088 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E07 compound treatment 9525000.0 -353000.0 -0.3 1.065496E7 553000.0 0.46 1.0615E7 684343.22580645 0.575450293838946 0.4217 0.5297 3220743 PK04_107089 COCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)N4CCOCC4)c(C(=O)OC)c3C(=O)OC)nn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E08 compound treatment 1.024148E7 364000.0 0.31 1.04002E7 298000.0 0.25 1.037668E7 446023.22580645 0.375051855078796 0.5399 0.9863 3188910 PK04_107090 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)c5ccc(o5)c6ccc(Cl)c(Cl)c6)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E09 mock treatment 1.02238E7 346000.0 0.3 1.051392E7 412000.0 0.34 1.044512E7 514463.22580645 0.432601658489104 0.6189 0.9879 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E10 mock treatment 1.048912E7 611000.0 0.53 1.095104E7 849000.0 0.7 1.063776E7 707103.22580645 0.594588714727588 1.0536 0.9928 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E11 compound treatment 1.044788E7 570000.0 0.49 1.05012E7 399000.0 0.33 1.166232E7 1731663.22580645 1.45612037139132 1.315 0.8366 3188911 PK04_107091 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E12 compound treatment 9835720.0 -42100.0 -0.04 1.08786E7 776000.0 0.64 1.049732E7 566663.22580645 0.476495576344424 0.626 0.7806 3070742 PK04_107092 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E13 compound treatment 1.085244E7 975000.0 0.84 1.055152E7 449000.0 0.37 1.0339E7 408343.22580645 0.343367509776335 0.8977 0.916 3188912 PK04_107093 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](C)Cn3cc(CN(C)C2=O)nn3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E14 compound treatment 1.055552E7 678000.0 0.58 1.085204E7 750000.0 0.62 1.113676E7 1206103.22580645 1.01418766127557 1.2814 0.9671 3070746 PK04_107094 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E15 compound treatment 1.065144E7 774000.0 0.67 1.05058E7 404000.0 0.33 1.086708E7 936423.22580645 0.787419236616131 1.0323 0.9522 3188913 PK04_107095 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E16 compound treatment 9346600.0 -531000.0 -0.46 9695400.0 -407000.0 -0.34 9812240.0 -118416.77419355 -0.0995742559222918 -0.5163 -0.8949 3070750 PK04_107096 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E17 mock treatment 9443040.0 -435000.0 -0.37 1.076652E7 664000.0 0.55 1.084732E7 916663.22580645 0.770803454684692 0.5471 0.5371 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E18 mock treatment 1.0394E7 516000.0 0.44 1.122032E7 1120000.0 0.93 1.105644E7 1125783.22580645 0.94664820759474 1.3385 0.9576 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E19 compound treatment 1.011808E7 240000.0 0.21 1.089216E7 790000.0 0.66 1.011972E7 189063.22580645 0.158979419597895 0.5895 0.8358 3220747 PK04_107097 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCCC2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E20 compound treatment 9613880.0 -264000.0 -0.23 9917880.0 -184000.0 -0.15 9679320.0 -251336.77419355 -0.211343979319402 -0.3415 -0.9871 3188915 PK04_107098 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E21 compound treatment 1.015996E7 282000.0 0.24 1.014064E7 38400.0 0.03 1.025692E7 326263.22580645 0.27434810790728 0.317 0.862 3220749 PK04_107099 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCC(C)C)oc(C(=O)Cc2ccccc2)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E22 compound treatment 1.019696E7 319000.0 0.27 1.028412E7 182000.0 0.15 9796360.0 -134296.77419355 -0.112927424802416 0.1805 0.5419 3070803 PK04_107100 CC(C)[Si](O[Si](C#Cc1ccc(Oc2ccccc2)cc1)(C(C)C)C(C)C)(C#Cc3ccc(Oc4ccccc4)cc3)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E23 compound treatment 9621040.0 -257000.0 -0.22 1.019168E7 89500.0 0.07 9532560.0 -398096.77419355 -0.334751477105738 -0.278 -0.6815 3220751 PK04_107101 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2ccc(OC)cc2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 E24 compound treatment 8407440.0 -1470000.0 -1.27 9136720.0 -966000.0 -0.8 8167080.0 -1763576.77419355 -1.48295582486593 -2.0492 -0.9723 3070808 PK04_107102 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)c6ccccc6)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F01 mock treatment 9039040.0 -839000.0 -0.72 8516360.0 -1590000.0 -1.32 9163520.0 -767136.77419355 -0.645069704027716 -1.5488 -0.9482 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F02 mock treatment 9477800.0 -400000.0 -0.34 9272600.0 -830000.0 -0.69 9157640.0 -773016.77419355 -0.650014076383833 -0.9714 -0.9643 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F03 compound treatment 1.015088E7 273000.0 0.23 1.044672E7 344000.0 0.29 1.001344E7 82783.2258064505 0.0696107301407421 0.3409 0.9054 3188918 PK04_107103 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F04 compound treatment 9888960.0 11100.0 0.01 1.054852E7 446000.0 0.37 1.0048E7 117343.22580645 0.0986715309277126 0.2763 0.7208 3188919 PK04_107104 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F05 compound treatment 9922680.0 44800.0 0.04 1.038424E7 282000.0 0.23 1.020148E7 270823.22580645 0.227729739978182 0.2888 0.8786 3188920 PK04_107105 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F06 compound treatment 1.045344E7 576000.0 0.5 1.08702E7 768000.0 0.64 1.009056E7 159903.22580645 0.134459368933889 0.7315 0.894 3188921 PK04_107106 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F07 compound treatment 9575640.0 -302000.0 -0.26 9889000.0 -213000.0 -0.18 9785280.0 -145376.77419355 -0.122244371351016 -0.3229 -0.9568 3070852 PK04_107107 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F08 compound treatment 1.004244E7 165000.0 0.14 1.11582E7 1060000.0 0.88 1.04466E7 515943.22580645 0.433846160374658 0.838 0.8484 3188922 PK04_107108 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F09 mock treatment 1.013668E7 259000.0 0.22 1.015284E7 50600.0 0.04 1.007896E7 148303.22580645 0.12470516496604 0.2249 0.8691 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F10 mock treatment 1.045652E7 579000.0 0.5 1.054904E7 447000.0 0.37 1.062184E7 691183.22580645 0.581201910661368 0.8371 0.9843 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F11 compound treatment 1.029852E7 421000.0 0.36 1.063188E7 530000.0 0.44 9993920.0 63263.2258064505 0.0531967593258792 0.4934 0.8629 3189029 PK04_107109 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F12 compound treatment 1.054508E7 667000.0 0.57 1.071084E7 609000.0 0.5 1.06836E7 752943.22580645 0.633134637993639 0.9886 0.9958 3070859 PK04_107110 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F13 compound treatment 1.019172E7 314000.0 0.27 1.092464E7 822000.0 0.68 1.0178E7 247343.22580645 0.207985885739812 0.6699 0.8784 3189030 PK04_107111 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F14 compound treatment 1.044152E7 564000.0 0.49 9945000.0 -157000.0 -0.13 1.046688E7 536223.22580645 0.450899199725345 0.4651 0.689 3189031 PK04_107112 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F15 compound treatment 1.03324E7 455000.0 0.39 1.110112E7 999000.0 0.83 1.056444E7 633783.22580645 0.532935418613564 1.012 0.9546 3070862 PK04_107113 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F16 compound treatment 1.013864E7 261000.0 0.22 1.04762E7 374000.0 0.31 1.02562E7 325543.22580645 0.273742674557552 0.4668 0.9916 3189032 PK04_107114 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F17 mock treatment 1.042928E7 551000.0 0.47 1.121264E7 1110000.0 0.92 1.070492E7 774263.22580645 0.651062192182823 1.1817 0.9656 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F18 mock treatment 1.06198E7 742000.0 0.64 1.088756E7 785000.0 0.65 1.043844E7 507783.22580645 0.426984582411067 0.9913 0.9842 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F19 compound treatment 1.052176E7 644000.0 0.55 1.090356E7 801000.0 0.66 1.074488E7 814223.22580645 0.684663743092758 1.0991 0.9959 3189033 PK04_107115 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F20 compound treatment 1.065136E7 774000.0 0.67 1.043864E7 336000.0 0.28 1.06116E7 680943.22580645 0.572591303020784 0.8761 0.9508 3070022 PK04_107116 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F21 compound treatment 1.005204E7 174000.0 0.15 1.086736E7 765000.0 0.63 1.008632E7 155663.22580645 0.13089403920771 0.5286 0.7946 3189034 PK04_107117 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F22 compound treatment 1.070004E7 822000.0 0.71 1.0413E7 311000.0 0.26 1.026224E7 331583.22580645 0.278821587658052 0.7184 0.8945 3189035 PK04_107118 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F23 compound treatment 9605720.0 -272000.0 -0.23 1.01794E7 77200.0 0.06 9589880.0 -340776.77419355 -0.286552255430126 -0.2637 -0.7021 3070031 PK04_107119 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 F24 compound treatment 8363680.0 -1510000.0 -1.3 8930600.0 -1170000.0 -0.97 8348200.0 -1582456.77419355 -1.33065570222311 -2.0818 -0.9909 3189036 PK04_107120 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G01 compound treatment 8438960.0 -1440000.0 -1.24 8556000.0 -1550000.0 -1.28 9542360.0 -388296.77419355 -0.32651085651221 -1.644 -0.907 3220772 PK04_107121 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCc2c[nH]c3ccccc23)oc(C(=O)Cc4ccccc4)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G02 compound treatment 9101280.0 -777000.0 -0.67 9199640.0 -903000.0 -0.75 9708240.0 -222416.77419355 -0.187025739771971 -0.9261 -0.9072 3070078 PK04_107122 CC[C@@H]1O[Si](C(C)C)(C(C)C)c2c1cc(nc2c3ccc(Oc4ccccc4)cc3)c5cc(C)c(OC)c(C)c5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G03 mock treatment 9586280.0 -292000.0 -0.25 9732640.0 -370000.0 -0.31 9537880.0 -392776.77419355 -0.330277997354966 -0.5126 -0.9937 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G04 mock treatment 1.004416E7 166000.0 0.14 1.013788E7 35700.0 0.03 9980920.0 50263.2258064505 0.0422653238446692 0.1241 0.8158 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G05 compound treatment 1.017236E7 295000.0 0.25 1.001252E7 -89700.0 -0.07 1.020744E7 276783.22580645 0.232741382706491 0.2378 0.6753 3220775 PK04_107123 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2nc[nH]n2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G06 compound treatment 1.00316E7 154000.0 0.13 1.014636E7 44100.0 0.04 1.035844E7 427783.22580645 0.359714210219006 0.3052 0.7927 3070081 PK04_107124 CC(C)[Si]1(OCc2c1c(nc(c3ccc(o3)c4ccc(Cl)c(Cl)c4)c2C)c5ccccc5)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G07 compound treatment 1.00604E7 183000.0 0.16 1.098492E7 883000.0 0.73 1.047876E7 548103.22580645 0.460888849995866 0.7796 0.8865 3189039 PK04_107125 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G08 compound treatment 1.01074E7 230000.0 0.2 1.004264E7 -59600.0 -0.05 1.0119E7 188343.22580645 0.158373986248167 0.177 0.6859 3189040 PK04_107126 COc1c(C)cc(cc1C)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G09 compound treatment 9961040.0 83200.0 0.07 1.134784E7 1250000.0 1.03 9804240.0 -126416.77419355 -0.106301293141498 0.5766 0.5537 3070086 PK04_107127 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(CCCNC(=N)N)nn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G10 compound treatment 9636240.0 -242000.0 -0.21 1.042088E7 319000.0 0.26 1.042352E7 492863.22580645 0.414438657997248 0.2719 0.5093 3189041 PK04_107128 COc1ccc(cn1)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G11 compound treatment 1.014424E7 266000.0 0.23 1.134644E7 1240000.0 1.03 1.049208E7 561423.22580645 0.472089366965844 1.0009 0.8643 3070089 PK04_107129 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G12 compound treatment 1.015964E7 282000.0 0.24 1.096392E7 862000.0 0.71 1.149476E7 1564103.22580645 1.31522257683504 1.3121 0.8652 3189042 PK04_107130 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G13 compound treatment 9965480.0 87600.0 0.08 1.13138E7 1210000.0 1.01 1.029636E7 365703.22580645 0.307512401397967 0.8014 0.7605 3070134 PK04_107131 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)C3(O)CCCCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G14 compound treatment 1.031112E7 433000.0 0.37 1.085924E7 757000.0 0.63 1.108256E7 1151903.22580645 0.968611984115448 1.1371 0.9373 3070137 PK04_107132 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G15 compound treatment 9985360.0 108000.0 0.09 1.064752E7 545000.0 0.45 1.078304E7 852383.22580645 0.716751710628371 0.7284 0.8543 3189043 PK04_107133 N[C@@H](Cc1ccccc1)Cn2cc(nn2)C3(O)CCCCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G16 compound treatment 9663760.0 -214000.0 -0.18 1.059212E7 490000.0 0.41 1.07622E7 831543.22580645 0.699227778672339 0.532 0.6413 3189044 PK04_107134 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G17 compound treatment 9975040.0 97200.0 0.08 1.014448E7 42300.0 0.04 1.074552E7 814863.22580645 0.685201906070294 0.4641 0.6715 3070143 PK04_107135 N[C@@H](Cc1ccccc1)Cn2cc(nn2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G18 compound treatment 1.032228E7 444000.0 0.38 1.09444E7 842000.0 0.7 1.074044E7 809783.22580645 0.680930237436098 1.0173 0.9708 3189045 PK04_107136 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)C4CC4)c5ccccc5)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G19 mock treatment 1.038864E7 511000.0 0.44 1.053696E7 435000.0 0.36 1.076848E7 837823.22580645 0.704508502889416 0.8688 0.9596 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G20 mock treatment 1.035164E7 474000.0 0.41 1.091348E7 811000.0 0.67 1.14368E7 1506143.22580645 1.2664851921819 1.3552 0.9089 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G21 compound treatment 9764760.0 -113000.0 -0.1 1.066496E7 563000.0 0.47 1.053392E7 603263.22580645 0.507271771622292 0.5062 0.7271 3070191 PK04_107137 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(Cc3ccccc3)nn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G22 compound treatment 1.003052E7 153000.0 0.13 1.01444E7 42200.0 0.03 9535120.0 -395536.77419355 -0.332598825195592 -0.096 -0.267 3189046 PK04_107138 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G23 compound treatment 9931320.0 53500.0 0.05 9977280.0 -125000.0 -0.1 9744040.0 -186616.77419355 -0.156922248216024 -0.1239 -0.6397 3070196 PK04_107139 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 G24 compound treatment 8445680.0 -1430000.0 -1.23 8995280.0 -1110000.0 -0.92 8564280.0 -1366376.77419355 -1.14895842693235 -1.9051 -0.9928 3189047 PK04_107140 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H01 compound treatment 9176560.0 -701000.0 -0.6 8489680.0 -1610000.0 -1.34 8815160.0 -1115496.77419355 -0.937998539738047 -1.6623 -0.9544 3189157 PK04_107141 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H02 compound treatment 9735200.0 -143000.0 -0.12 9763640.0 -339000.0 -0.28 9342320.0 -588336.77419355 -0.494720422178459 -0.5187 -0.8912 3189158 PK04_107142 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H03 mock treatment 9431560.0 -446000.0 -0.38 9753520.0 -349000.0 -0.29 9844720.0 -85936.7741935495 -0.072262484812315 -0.4305 -0.8853 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H04 mock treatment 1.012592E7 248000.0 0.21 1.043256E7 330000.0 0.27 1.050236E7 571703.22580645 0.480733609792524 0.559 0.9425 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H05 compound treatment 1.044212E7 564000.0 0.49 1.06912E7 589000.0 0.49 9883240.0 -47416.7741935495 -0.0398718006018375 0.5395 0.7818 3070201 PK04_107143 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H06 compound treatment 1.060592E7 728000.0 0.63 1.008576E7 -16500.0 -0.01 1.04726E7 541943.22580645 0.455709031337077 0.617 0.7962 3189159 PK04_107144 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H07 compound treatment 1.00096E7 132000.0 0.11 1.010388E7 1660.0 0.0 1.041856E7 487903.22580645 0.41026789492134 0.3031 0.7122 3071172 PK04_107145 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H08 compound treatment 1.043752E7 560000.0 0.48 1.084412E7 742000.0 0.62 9898960.0 -31696.7741935495 -0.0266531724660975 0.618 0.7903 3071173 PK04_107146 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H09 compound treatment 1.056312E7 685000.0 0.59 1.04352E7 333000.0 0.28 1.00938E7 163143.22580645 0.137183819007668 0.5792 0.8702 3071174 PK04_107147 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H10 compound treatment 1.082772E7 950000.0 0.82 1.132344E7 1220000.0 1.01 1.135916E7 1428503.22580645 1.2011992959695 1.7504 0.9882 3189160 PK04_107148 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H11 compound treatment 1.042344E7 546000.0 0.47 1.090528E7 803000.0 0.67 1.14256E7 1494943.22580645 1.25706734007501 1.3815 0.9221 3189161 PK04_107149 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H12 compound treatment 1.024076E7 363000.0 0.31 1.120428E7 1100000.0 0.91 1.107776E7 1147103.22580645 0.964575761783924 1.2651 0.9266 3071175 PK04_107150 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H13 compound treatment 1.031388E7 436000.0 0.38 1.097176E7 870000.0 0.72 1.109748E7 1166823.22580645 0.981157908529268 1.1996 0.9414 3189162 PK04_107151 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5ccc(cc5)c6ccccc6)c7cc(OCCCO)ccc27)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H14 compound treatment 1.068672E7 809000.0 0.7 1.071536E7 613000.0 0.51 1.135152E7 1420863.22580645 1.19477497542516 1.3854 0.9403 3189163 PK04_107152 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H15 compound treatment 1.008292E7 205000.0 0.18 1.09256E7 823000.0 0.68 1.136664E7 1435983.22580645 1.20748907576946 1.1934 0.8534 3071176 PK04_107153 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H16 compound treatment 1.108896E7 1210000.0 1.04 1.126052E7 1160000.0 0.96 1.121556E7 1284903.22580645 1.08044897788475 1.7804 0.9988 3189164 PK04_107154 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H17 compound treatment 1.091036E7 1030000.0 0.89 1.114672E7 1040000.0 0.87 1.049144E7 560783.22580645 0.471551203988308 1.2856 0.9683 3189165 PK04_107155 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc8ccccc8c7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H18 compound treatment 1.067468E7 797000.0 0.69 1.109176E7 990000.0 0.82 1.117196E7 1241303.22580645 1.04378662504008 1.4725 0.9853 3071177 PK04_107156 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H19 mock treatment 1.082712E7 949000.0 0.82 1.132744E7 1230000.0 1.02 1.128792E7 1357263.22580645 1.14129502953247 1.7174 0.9911 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H20 mock treatment 1.121468E7 1340000.0 1.15 1.123564E7 1130000.0 0.94 1.079964E7 868983.22580645 0.730710312858224 1.629 0.9838 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H21 compound treatment 1.016472E7 287000.0 0.25 1.101264E7 910000.0 0.76 1.060316E7 672503.22580645 0.565494278754521 0.9051 0.928 3189166 PK04_107157 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H22 compound treatment 9651920.0 -226000.0 -0.19 1.005432E7 -47900.0 -0.04 1.01758E7 245143.22580645 0.20613595050453 -0.0162 -0.0566 3189167 PK04_107158 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H23 compound treatment 9881480.0 3650.0 0.0 1.013476E7 32500.0 0.03 9546960.0 -383696.77419355 -0.322642810111167 -0.1689 -0.5216 3071178 PK04_107159 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc(cc7)c8ccccc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 H24 compound treatment 7783480.0 -2090000.0 -1.8 8513160.0 -1590000.0 -1.32 7867200.0 -2063456.77419355 -1.73511881502788 -2.8035 -0.9914 3189168 PK04_107160 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I01 compound treatment 8695240.0 -1180000.0 -1.02 9242640.0 -860000.0 -0.71 9414360.0 -516296.77419355 -0.434143452019508 -1.25 -0.9496 3071179 PK04_107161 CC(C)[C@@H](C(=O)O)n1cc(nn1)C2(O)CCCCC2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I02 compound treatment 8345200.0 -1530000.0 -1.32 8796360.0 -1310000.0 -1.08 9344920.0 -585736.77419355 -0.492534135082217 -1.6714 -0.9408 3189169 PK04_107162 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I03 compound treatment 9915560.0 37700.0 0.03 9638600.0 -464000.0 -0.38 9456360.0 -474296.77419355 -0.398826506618676 -0.4336 -0.7812 3071180 PK04_107163 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccn3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I04 compound treatment 9699040.0 -179000.0 -0.15 9610720.0 -492000.0 -0.41 9345400.0 -585256.77419355 -0.492130512849065 -0.6084 -0.9255 3189170 PK04_107164 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)cc(OC)c1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I05 mock treatment 9744640.0 -133000.0 -0.11 9780120.0 -322000.0 -0.27 9037760.0 -892896.77419355 -0.750818729113636 -0.6539 -0.8122 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I06 mock treatment 9994000.0 116000.0 0.1 1.043512E7 333000.0 0.28 1.01566E7 225943.22580645 0.189991061178436 0.3269 0.9344 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I07 compound treatment 8207880.0 -1670000.0 -1.44 8770000.0 -1330000.0 -1.11 8781600.0 -1149056.77419355 -0.966218460872616 -2.0257 -0.986 3071181 PK04_107165 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@]4(O[C@@]23[C@H]5[C@@H]4C(=O)N(C)C5=O)C(=O)C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I08 compound treatment 9273520.0 -604000.0 -0.52 1.015596E7 53700.0 0.04 1.033628E7 405623.22580645 0.341080317121805 -0.0776 -0.1245 3189171 PK04_107166 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I09 compound treatment 9645120.0 -233000.0 -0.2 9029680.0 -1070000.0 -0.89 9664240.0 -266416.77419355 -0.224024444477605 -0.7587 -0.8078 3189172 PK04_107167 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@@]4(O[C@]23[C@@H]5[C@H]4C(=O)N(C)C5=O)C(=O)C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I10 compound treatment 1.016176E7 284000.0 0.24 1.03108E7 209000.0 0.17 1.033544E7 404783.22580645 0.340373978213789 0.4375 0.9651 3071182 PK04_107168 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I11 compound treatment 1.056268E7 685000.0 0.59 1.13508E7 1250000.0 1.04 1.074948E7 818823.22580645 0.688531789493801 1.3358 0.9706 3189173 PK04_107169 NC(=N)NCc1cn(CCc2c[nH]c3ccccc23)nn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I12 compound treatment 1.092456E7 1050000.0 0.9 1.057692E7 475000.0 0.39 1.069464E7 763983.22580645 0.642417949356143 1.1184 0.9523 3189286 PK04_107170 CC(C)[Si]1(O[C@H](c2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I13 compound treatment 1.050524E7 627000.0 0.54 1.044392E7 342000.0 0.28 9984080.0 53423.2258064505 0.0449225035462557 0.5013 0.8199 3071183 PK04_107171 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@H](Cc4ccccc4)C(=O)N23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I14 compound treatment 8491920.0 -1390000.0 -1.19 8635120.0 -1470000.0 -1.22 9283200.0 -647456.77419355 -0.544433227228393 -1.7056 -0.9534 3189287 PK04_107172 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I15 compound treatment 9591040.0 -287000.0 -0.25 1.054784E7 446000.0 0.37 1.078644E7 855783.22580645 0.719610701446534 0.4864 0.5751 3071184 PK04_107173 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@@H](Cc4ccccc4)C(=O)N23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I16 compound treatment 1.000324E7 125000.0 0.11 9718480.0 -384000.0 -0.32 9907480.0 -23176.7741935495 -0.019488877827643 -0.1327 -0.3942 3189288 PK04_107174 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I17 compound treatment 9936800.0 59000.0 0.05 1.08412E7 739000.0 0.61 1.092408E7 993423.22580645 0.835349376802975 0.8655 0.8343 3071185 PK04_107175 COc1ccc(cc1)[C@H]2OC[C@@H]3CC4(CC=CC4)C(=O)N23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I18 compound treatment 9832280.0 -45600.0 -0.04 7942680.0 -2160000.0 -1.79 1.004464E7 113983.22580645 0.095846175295646 -1.0016 -0.5582 3189289 PK04_107176 COc1cc(Cc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5)cc(OC)c1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I19 compound treatment 9972640.0 94800.0 0.08 1.117736E7 1080000.0 0.89 1.088528E7 954623.22580645 0.802723246289825 1.0255 0.8527 3071186 PK04_107177 COc1ccc(cc1)[C@H]2OC[C@@H]3CCC(=O)N23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I20 compound treatment 1.00172E7 139000.0 0.12 9664720.0 -438000.0 -0.36 9551240.0 -379416.77419355 -0.319043845198892 -0.3245 -0.6517 3189171 PK04_107178 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I21 mock treatment 9605640.0 -272000.0 -0.23 9732640.0 -370000.0 -0.31 1.005892E7 128263.22580645 0.107853936731929 -0.25 -0.624 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I22 mock treatment 9999800.0 122000.0 0.1 1.031512E7 213000.0 0.18 1.000792E7 77263.2258064505 0.0649690744594899 0.2001 0.9285 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I23 compound treatment 9375960.0 -502000.0 -0.43 9480280.0 -622000.0 -0.52 9141280.0 -789376.77419355 -0.663770867497109 -0.9305 -0.9845 3189290 PK04_107179 COc1ccc(cc1)[C@H]2OC[C@@H]3CC(CC=C)(CC=C)C(=O)N23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 I24 compound treatment 8423560.0 -1450000.0 -1.25 8934080.0 -1170000.0 -0.97 7679280.0 -2251376.77419355 -1.89313691930703 -2.3751 -0.9625 3071182 PK04_107180 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J01 compound treatment 8270680.0 -1610000.0 -1.38 8178080.0 -1920000.0 -1.6 8262160.0 -1668496.77419355 -1.40300498751567 -2.5302 -0.9978 3189291 PK04_107181 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J02 compound treatment 9044760.0 -833000.0 -0.72 8755440.0 -1350000.0 -1.12 9080720.0 -849936.77419355 -0.7146945392465 -1.4716 -0.9761 3071187 PK04_107182 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J03 compound treatment 1.0044E7 166000.0 0.14 9438240.0 -664000.0 -0.55 9759160.0 -171496.77419355 -0.144208147871724 -0.3187 -0.5429 3189292 PK04_107183 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J04 compound treatment 9988240.0 110000.0 0.1 1.0122E7 19800.0 0.02 1.021312E7 282463.22580645 0.237517579132127 0.2015 0.7859 3189293 PK04_107184 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J05 mock treatment 9988680.0 111000.0 0.1 9437960.0 -664000.0 -0.55 9748880.0 -181776.77419355 -0.152852390698404 -0.3513 -0.606 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J06 mock treatment 9979320.0 101000.0 0.09 1.001252E7 -89700.0 -0.07 9477560.0 -453096.77419355 -0.38099985798778 -0.2125 -0.5341 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J07 compound treatment 9713680.0 -164000.0 -0.14 1.041184E7 310000.0 0.26 9686440.0 -244216.77419355 -0.205356916194308 -0.0518 -0.1448 3071188 PK04_107185 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J08 compound treatment 1.043708E7 559000.0 0.48 1.08462E7 744000.0 0.62 1.101E7 1079343.22580645 0.907597756537249 1.1582 0.9664 3189294 PK04_107186 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J09 compound treatment 1.05636E7 686000.0 0.59 1.072908E7 627000.0 0.52 1.019804E7 267383.22580645 0.224837113973923 0.7708 0.9422 3189295 PK04_107187 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J10 compound treatment 1.073284E7 855000.0 0.74 1.049592E7 394000.0 0.33 1.124804E7 1317383.22580645 1.10776074899473 1.253 0.915 3071189 PK04_107188 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J11 compound treatment 1.017036E7 293000.0 0.25 1.0678E7 576000.0 0.48 1.050016E7 569503.22580645 0.478883674557243 0.6976 0.9666 3189296 PK04_107189 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J12 compound treatment 1.011328E7 235000.0 0.2 1.138288E7 1280000.0 1.06 1.063612E7 705463.22580645 0.593209672097651 1.0729 0.8697 3189297 PK04_107190 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J13 compound treatment 9574800.0 -303000.0 -0.26 1.091908E7 817000.0 0.68 1.059772E7 667063.22580645 0.560919893445461 0.5645 0.6153 3071190 PK04_107191 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J14 compound treatment 1.036548E7 488000.0 0.42 1.068828E7 586000.0 0.49 1.007252E7 141863.22580645 0.119289900004579 0.5919 0.906 3189298 PK04_107192 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J15 compound treatment 9736680.0 -141000.0 -0.12 1.0294E7 192000.0 0.16 1.020628E7 275623.22580645 0.231765962309706 0.1555 0.5079 3071191 PK04_107193 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J16 compound treatment 1.073264E7 855000.0 0.74 1.03636E7 261000.0 0.22 1.043224E7 501583.22580645 0.421771128566183 0.7934 0.9065 3189299 PK04_107194 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J17 compound treatment 9495000.0 -383000.0 -0.33 9159200.0 -943000.0 -0.78 8962640.0 -968016.77419355 -0.813985608601982 -1.1118 -0.9454 3189300 PK04_107195 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J18 compound treatment 9652880.0 -225000.0 -0.19 1.04032E7 301000.0 0.25 1.02336E7 302943.22580645 0.254738794413295 0.1795 0.4422 3071192 PK04_107196 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J19 compound treatment 9852280.0 -25600.0 -0.02 1.04708E7 369000.0 0.31 9693920.0 -236736.77419355 -0.19906713639435 0.0489 0.1338 3189301 PK04_107197 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J20 compound treatment 1.018576E7 308000.0 0.27 1.089012E7 788000.0 0.65 1.0226E7 295343.22580645 0.248348109055049 0.6738 0.901 3189302 PK04_107198 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J21 mock treatment 9818640.0 -59200.0 -0.05 1.020672E7 104000.0 0.09 9584120.0 -346536.77419355 -0.291395722227954 -0.1476 -0.4788 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J22 mock treatment 9851400.0 -26400.0 -0.02 9814720.0 -288000.0 -0.24 9535720.0 -394936.77419355 -0.332094297404151 -0.3426 -0.8366 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J23 compound treatment 9988160.0 110000.0 0.09 9669440.0 -433000.0 -0.36 8321720.0 -1608936.77419355 -1.35292219541868 -0.9336 -0.6654 3071251 PK04_107199 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 J24 compound treatment 8531000.0 -1350000.0 -1.16 8501720.0 -1600000.0 -1.33 7603800.0 -2326856.77419355 -1.95660651547024 -2.5654 -0.9742 3189414 PK04_107200 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K01 compound treatment 8258080.0 -1620000.0 -1.39 8267320.0 -1830000.0 -1.52 8227360.0 -1703296.77419355 -1.43226759941922 -2.5106 -0.9993 3071252 PK04_107201 COc1cccc(C[C@H]2C[C@@H](CO)NC2=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K02 compound treatment 8962680.0 -915000.0 -0.79 9542400.0 -560000.0 -0.46 9354120.0 -576536.77419355 -0.48479804228013 -1.0028 -0.9689 3189415 PK04_107202 CCCCCCC#C[Si](O[C@@H](C#C)c1ccccc1)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K03 compound treatment 9276160.0 -602000.0 -0.52 9921680.0 -181000.0 -0.15 1.000284E7 72183.2258064505 0.060697405825294 -0.3504 -0.6459 3071253 PK04_107203 COC(=O)c1c(CC[C@@H](CO)NC(=O)N(C)Cc2ccccc2)oc(C(=O)OCC=C)c1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K04 compound treatment 9709440.0 -168000.0 -0.14 9879400.0 -223000.0 -0.18 9959920.0 29263.2258064505 0.0246068511442532 -0.1762 -0.746 3189416 PK04_107204 CCCCCCC#C[Si](OCC#CC)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K05 compound treatment 9688000.0 -190000.0 -0.16 1.029712E7 195000.0 0.16 9275760.0 -654896.77419355 -0.550689371842254 -0.3189 -0.5344 3189417 PK04_107205 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(COC2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K06 compound treatment 9874520.0 -3310.0 0.0 1.019172E7 89500.0 0.07 9757240.0 -173416.77419355 -0.145822636804334 -0.043 -0.2626 3071254 PK04_107206 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccccc2)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K07 mock treatment 1.00852E7 207000.0 0.18 1.074832E7 646000.0 0.54 1.0141E7 210343.22580645 0.176873338600984 0.5146 0.8693 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K08 mock treatment 9460400.0 -417000.0 -0.36 1.00096E7 -92600.0 -0.08 1.001952E7 88863.2258064505 0.0747232784273388 -0.2086 -0.5565 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K09 compound treatment 9913640.0 35800.0 0.03 9920840.0 -181000.0 -0.15 9529560.0 -401096.77419355 -0.33727411606294 -0.2638 -0.7118 3071255 PK04_107207 NC(=N)NCC#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K10 compound treatment 1.118356E7 1310000.0 1.12 1.074944E7 647000.0 0.54 9850640.0 -80016.7741935495 -0.0672844772701025 0.9199 0.7376 3189418 PK04_107208 CC#CCO[Si](C#Cc1ccccc1)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K11 compound treatment 9830280.0 -47600.0 -0.04 1.037596E7 274000.0 0.23 1.041868E7 488023.22580645 0.410368800479628 0.3444 0.7315 3189419 PK04_107209 OC(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K12 compound treatment 1.07572E7 879000.0 0.76 1.024664E7 144000.0 0.12 8062520.0 -1868136.77419355 -1.57087820132096 -0.4008 -0.2293 3071256 PK04_107210 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccc(Oc3ccccc3)cc2)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K13 compound treatment 8887680.0 -990000.0 -0.85 9956280.0 -146000.0 -0.12 9420320.0 -510336.77419355 -0.4291318092912 -0.8097 -0.8418 3189420 PK04_107211 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@](Cc4ccccc4)(C(=O)OCC=C)C(=O)N23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K14 compound treatment 9424680.0 -453000.0 -0.39 1.08786E7 776000.0 0.64 1.02452E7 314543.22580645 0.264492998381143 0.2994 0.3752 3071257 PK04_107212 CC[C@@H](O[Si](C#Cc1ccc(Oc2ccccc2)cc1)(C(C)C)C(C)C)C#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K15 mock treatment 1.02538E7 376000.0 0.32 1.083772E7 735000.0 0.61 1.014844E7 217783.22580645 0.183129483214845 0.6448 0.9025 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K16 mock treatment 1.0299E7 421000.0 0.36 1.066448E7 562000.0 0.47 1.060744E7 676783.22580645 0.569093243666797 0.8071 0.984 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K17 compound treatment 1.006452E7 187000.0 0.16 1.083944E7 737000.0 0.61 1.068116E7 750503.22580645 0.631082891641781 0.8102 0.9069 1035256 PK04_107213 C#CCNCc1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K18 compound treatment 1.069704E7 819000.0 0.71 1.090476E7 803000.0 0.67 1.05928E7 662143.22580645 0.556782765555649 1.1129 0.9953 3189421 PK04_107214 CC(C)[Si](Oc1ccccc1Br)(C#CCCCC#N)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K19 compound treatment 1.018276E7 305000.0 0.26 1.115552E7 1050000.0 0.87 1.020436E7 273703.22580645 0.230151473377096 0.7889 0.8384 3071258 PK04_107215 CC(C)[C@H](N=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K20 compound treatment 1.026296E7 385000.0 0.33 1.020188E7 99700.0 0.08 1.02474E7 316743.22580645 0.266342933616425 0.3929 0.907 3189422 PK04_107216 CC[C@@H](O[Si](C#CCCCC#N)(C(C)C)C(C)C)C#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K21 compound treatment 9461160.0 -417000.0 -0.36 9964280.0 -138000.0 -0.11 9530040.0 -400616.77419355 -0.336870493829788 -0.4676 -0.9257 3189423 PK04_107217 [N-]=[N+]=NC[C@H](Cc1ccccc1)NC(=O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K22 compound treatment 9674640.0 -203000.0 -0.17 9838320.0 -264000.0 -0.22 9117960.0 -812696.77419355 -0.683380180991095 -0.6219 -0.842 3071259 PK04_107218 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#Cc4ccccc4)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K23 mock treatment 9278400.0 -599000.0 -0.52 9808920.0 -293000.0 -0.24 8862560.0 -1068096.77419355 -0.89814084421425 -0.9569 -0.8994 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 K24 mock treatment 8373520.0 -1500000.0 -1.29 9177160.0 -925000.0 -0.77 7849360.0 -2081296.77419355 -1.75012010802671 -2.201 -0.9535 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L01 compound treatment 9027680.0 -850000.0 -0.73 9453080.0 -649000.0 -0.54 8895800.0 -1034856.77419355 -0.870190004568449 -1.2357 -0.9823 3189424 PK04_107219 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L02 compound treatment 9734240.0 -144000.0 -0.12 9245760.0 -856000.0 -0.71 9449160.0 -481496.77419355 -0.404880840115962 -0.7153 -0.8649 3189425 PK04_107220 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L03 compound treatment 9976400.0 98600.0 0.08 9981880.0 -120000.0 -0.1 1.0827E7 896343.22580645 0.753716780147909 0.4265 0.5575 3071260 PK04_107221 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L04 compound treatment 1.007604E7 198000.0 0.17 1.054472E7 442000.0 0.37 1.01304E7 199743.22580645 0.167960014285536 0.4074 0.9296 3189426 PK04_107222 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L05 compound treatment 1.031816E7 440000.0 0.38 1.051156E7 409000.0 0.34 9755560.0 -175096.77419355 -0.147235314620367 0.3298 0.6227 3189427 PK04_107223 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L06 compound treatment 1.066496E7 787000.0 0.68 1.083144E7 729000.0 0.6 1.033636E7 405703.22580645 0.341147587493997 0.9373 0.9662 3071261 PK04_107224 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L07 mock treatment 1.011396E7 236000.0 0.2 1.052196E7 420000.0 0.35 9823120.0 -107536.77419355 -0.0904254853041715 0.2662 0.6442 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L08 mock treatment 9717440.0 -160000.0 -0.14 1.091632E7 814000.0 0.68 1.008352E7 152863.22580645 0.128539576180988 0.3844 0.5482 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L09 compound treatment 1.042776E7 550000.0 0.47 1.066904E7 567000.0 0.47 1.020804E7 277383.22580645 0.233245910497931 0.6794 0.9613 3189428 PK04_107225 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L10 compound treatment 1.031508E7 437000.0 0.38 1.089504E7 793000.0 0.66 9990240.0 59583.2258064505 0.0501023222050444 0.6259 0.8242 3189429 PK04_107226 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L11 compound treatment 9956640.0 78800.0 0.07 1.002992E7 -72300.0 -0.06 1.001556E7 84903.2258064505 0.0713933950038318 0.0457 0.3968 3071262 PK04_107227 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L12 compound treatment 9595280.0 -283000.0 -0.24 1.028884E7 187000.0 0.15 1.012276E7 192103.22580645 0.161535693741194 0.0422 0.1278 3189430 PK04_107228 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L13 compound treatment 1.062096E7 743000.0 0.64 1.116932E7 1070000.0 0.89 1.070368E7 773023.22580645 0.650019501413846 1.2556 0.988 3189431 PK04_107229 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)Cc5ccc(F)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L14 compound treatment 9852880.0 -25000.0 -0.02 9937840.0 -164000.0 -0.14 1.057924E7 648583.22580645 0.545380437469095 0.2237 0.3977 3071263 PK04_107230 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L15 mock treatment 1.043048E7 553000.0 0.48 1.034256E7 240000.0 0.2 1.00092E7 78543.2258064505 0.0660454004145629 0.4278 0.8229 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L16 mock treatment 9880920.0 3090.0 0.0 9800240.0 -302000.0 -0.25 1.039884E7 468183.22580645 0.393685748175997 0.0842 0.1804 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L17 compound treatment 1.014292E7 265000.0 0.23 1.004568E7 -56500.0 -0.05 1.004736E7 116703.22580645 0.0981333679501761 0.1613 0.6382 3189432 PK04_107231 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L18 compound treatment 9973000.0 95200.0 0.08 1.060968E7 507000.0 0.42 9388600.0 -542056.77419355 -0.455804511865352 0.0272 0.0434 3189547 PK04_107232 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L19 compound treatment 1.028508E7 407000.0 0.35 1.09256E7 823000.0 0.68 1.023044E7 299783.22580645 0.252081614711708 0.7423 0.9186 3071264 PK04_107233 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L20 compound treatment 1.009144E7 214000.0 0.18 1.044384E7 342000.0 0.28 9905480.0 -25176.7741935495 -0.0211706371324445 0.2575 0.7609 3189548 PK04_107234 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L21 compound treatment 9828120.0 -49700.0 -0.04 1.00454E7 -56800.0 -0.05 9377000.0 -553656.77419355 -0.465558715833201 -0.3207 -0.6825 3189549 PK04_107235 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L22 compound treatment 1.017684E7 299000.0 0.26 9696640.0 -406000.0 -0.34 9741720.0 -188936.77419355 -0.158873089009594 -0.1374 -0.3037 3071265 PK04_107236 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L23 mock treatment 9589880.0 -288000.0 -0.25 9786040.0 -316000.0 -0.26 9241160.0 -689496.77419355 -0.579783807815321 -0.6293 -0.9214 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 L24 mock treatment 8135280.0 -1740000.0 -1.5 8757680.0 -1340000.0 -1.12 8135520.0 -1795136.77419355 -1.5094939866957 -2.3813 -0.9912 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M01 compound treatment 8308320.0 -1570000.0 -1.35 8060080.0 -2040000.0 -1.69 8267480.0 -1663176.77419355 -1.3985315077649 -2.5654 -0.9948 3189550 PK04_107237 COc1cccc(C[C@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M02 compound treatment 8480080.0 -1400000.0 -1.2 8934440.0 -1170000.0 -0.97 9185400.0 -745256.77419355 -0.626671257233188 -1.6157 -0.9693 3071266 PK04_107238 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCc4ccccc4)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M03 compound treatment 8893600.0 -984000.0 -0.85 9137960.0 -964000.0 -0.8 9246360.0 -684296.77419355 -0.575411233622837 -1.2831 -0.9874 3189551 PK04_107239 COc1cccc(C[C@@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M04 compound treatment 9033240.0 -845000.0 -0.73 9547960.0 -554000.0 -0.46 9951840.0 21183.2258064505 0.017812543552855 -0.6749 -0.7844 3189552 PK04_107240 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M05 compound treatment 9212280.0 -666000.0 -0.57 9651000.0 -451000.0 -0.37 1.044716E7 516503.22580645 0.434317052980002 -0.2961 -0.3653 3071267 PK04_107241 CN(C)S(=O)(=O)NCC#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M06 compound treatment 9647640.0 -230000.0 -0.2 9958480.0 -144000.0 -0.12 1.059336E7 662703.22580645 0.557253658160994 0.1385 0.2296 3189553 PK04_107242 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](CO)Cc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M07 compound treatment 9449000.0 -429000.0 -0.37 9611400.0 -491000.0 -0.41 9372600.0 -558056.77419355 -0.469258586303764 -0.7191 -0.9951 3414058 PK04_107243 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M08 compound treatment 9549200.0 -329000.0 -0.28 1.031196E7 210000.0 0.17 9775240.0 -155416.77419355 -0.13068680306112 -0.1383 -0.3875 3189554 PK04_107244 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(Cc2cccc(Cl)c2)nn1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M09 mock treatment 9604680.0 -273000.0 -0.24 9742560.0 -360000.0 -0.3 9289960.0 -640696.77419355 -0.538748880778163 -0.619 -0.9391 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M10 mock treatment 9921280.0 43400.0 0.04 1.032952E7 227000.0 0.19 9561560.0 -369096.77419355 -0.310365967186116 -0.0487 -0.1335 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M11 compound treatment 1.004472E7 167000.0 0.14 9530680.0 -572000.0 -0.47 9905080.0 -25576.7741935495 -0.0215069889934048 -0.2032 -0.4098 3189555 PK04_107245 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M12 compound treatment 1.056016E7 682000.0 0.59 1.06928E7 591000.0 0.49 9851680.0 -78976.7741935495 -0.0664099624316056 0.5836 0.7602 3071269 PK04_107246 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](C)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M13 mock treatment 9925080.0 47200.0 0.04 1.110504E7 1000000.0 0.83 1.036896E7 438303.22580645 0.368560264162262 0.7166 0.7867 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M14 mock treatment 1.001348E7 136000.0 0.12 1.032664E7 224000.0 0.19 9969640.0 38983.2258064505 0.0327802013655886 0.1938 0.8723 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M15 compound treatment 9783200.0 -94600.0 -0.08 1.048848E7 386000.0 0.32 1.026648E7 335823.22580645 0.282386917384232 0.301 0.6923 3189556 PK04_107247 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M16 compound treatment 9557960.0 -320000.0 -0.28 1.02318E7 130000.0 0.11 9741760.0 -188896.77419355 -0.158839453823498 -0.1886 -0.5621 3189557 PK04_107248 CCCC#C[Si](O[C@H](CC)c1cn(Cc2ccccc2)nn1)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M17 compound treatment 1.012336E7 246000.0 0.21 1.082984E7 728000.0 0.6 9618760.0 -311896.77419355 -0.262267651068792 0.3191 0.4616 3189558 PK04_107249 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H](Cc5ccccc5)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M18 compound treatment 9799840.0 -78000.0 -0.07 9390960.0 -711000.0 -0.59 9857320.0 -73336.7741935495 -0.0616674011920653 -0.415 -0.6951 3071329 PK04_107250 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M19 compound treatment 9652360.0 -225000.0 -0.19 9813640.0 -289000.0 -0.24 9594520.0 -336136.77419355 -0.282650573842986 -0.4134 -0.9887 3189559 PK04_107251 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H]5CCCN5C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M20 compound treatment 9553680.0 -324000.0 -0.28 9995400.0 -107000.0 -0.09 9566640.0 -364016.77419355 -0.30609429855192 -0.389 -0.9184 3071330 PK04_107252 CCCC#C[Si](O[C@H](CC)c1cn(Cc2cccc(Cl)c2)nn1)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M21 compound treatment 9623360.0 -254000.0 -0.22 9657320.0 -445000.0 -0.37 9162720.0 -767936.77419355 -0.645742407749637 -0.7124 -0.9187 3189560 PK04_107253 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H]5CCCN5C2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M22 compound treatment 9485360.0 -392000.0 -0.34 9406320.0 -696000.0 -0.58 8729640.0 -1201016.77419355 -1.00991056761136 -1.1114 -0.9175 3071331 PK04_107254 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](C)c2ccccc2)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M23 compound treatment 9421320.0 -457000.0 -0.39 9751760.0 -350000.0 -0.29 9164600.0 -766056.77419355 -0.644161554003123 -0.7666 -0.9481 3189561 PK04_107255 CN1Cc2cn(C[C@H](Cc3ccccc3)NC(=O)c4cc(c(CC[C@@H](CO)NC1=O)o4)S(=O)(=O)c5ccc(C)cc5)nn2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 M24 compound treatment 8119840.0 -1760000.0 -1.51 8539000.0 -1560000.0 -1.3 7789520.0 -2141136.77419355 -1.80043834642637 -2.6617 -0.9911 3071332 PK04_107256 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N01 compound treatment 8399160.0 -1480000.0 -1.27 8495320.0 -1610000.0 -1.33 8258800.0 -1671856.77419355 -1.40583034314774 -2.316 -0.9992 3189562 PK04_107257 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)Cc4ccc(F)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N02 compound treatment 9369040.0 -509000.0 -0.44 9311200.0 -791000.0 -0.66 9207560.0 -723096.77419355 -0.608037364135987 -0.9827 -0.9866 3189563 PK04_107258 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N03 compound treatment 9766400.0 -111000.0 -0.1 9479320.0 -623000.0 -0.52 9255360.0 -675296.77419355 -0.56784331675123 -0.6816 -0.8809 3071333 PK04_107259 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(o3)c4cccc(c4)C(F)(F)F)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N04 compound treatment 9863400.0 -14400.0 -0.01 1.065896E7 557000.0 0.46 9717400.0 -213256.77419355 -0.17932328215598 0.1559 0.3147 3189564 PK04_107260 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N05 compound treatment 9041600.0 -836000.0 -0.72 9951040.0 -151000.0 -0.13 9338280.0 -592376.77419355 -0.498117575974159 -0.7755 -0.8771 3189681 PK04_107261 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N06 compound treatment 9889920.0 12100.0 0.01 1.0042E7 -60200.0 -0.05 9590160.0 -340496.77419355 -0.286316809127454 -0.1881 -0.6469 3071334 PK04_107262 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N07 compound treatment 9749800.0 -128000.0 -0.11 1.0042E7 -60200.0 -0.05 1.001584E7 85183.2258064505 0.071628841306504 -0.0511 -0.3635 3189682 PK04_107263 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N08 compound treatment 9796840.0 -81000.0 -0.07 9750760.0 -351000.0 -0.29 9375280.0 -555376.77419355 -0.46700502883533 -0.4782 -0.8617 3071335 PK04_107264 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N09 mock treatment 9601800.0 -276000.0 -0.24 9622640.0 -480000.0 -0.4 9147840.0 -782816.77419355 -0.65825469697736 -0.7469 -0.9278 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N10 mock treatment 1.0273E7 395000.0 0.34 1.051604E7 414000.0 0.34 9312200.0 -618456.77419355 -0.52004771730877 0.0943 0.1328 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N11 compound treatment 9887480.0 9650.0 0.01 1.00922E7 -10000.0 -0.01 9202040.0 -728616.77419355 -0.612679019817239 -0.3537 -0.5773 3189683 PK04_107265 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N12 compound treatment 9952800.0 75000.0 0.06 1.024344E7 141000.0 0.12 9715560.0 -215096.77419355 -0.180870500716398 5.0E-4 0.0021 3189684 PK04_107266 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N13 mock treatment 9962240.0 84400.0 0.07 9769600.0 -333000.0 -0.28 9692920.0 -237736.77419355 -0.199908016046751 -0.2328 -0.6682 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N14 mock treatment 9924840.0 47000.0 0.04 9769440.0 -333000.0 -0.28 9466160.0 -464496.77419355 -0.390585886025149 -0.3615 -0.7532 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N15 compound treatment 9656600.0 -221000.0 -0.19 9952600.0 -150000.0 -0.12 9730320.0 -200336.77419355 -0.168459117046963 -0.2789 -0.9857 3071336 PK04_107267 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(o2)c3cccc(c3)C(F)(F)F)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N16 compound treatment 9452520.0 -425000.0 -0.37 1.021644E7 114000.0 0.09 9943160.0 12503.2258064505 0.0105137081700163 -0.1506 -0.398 3189685 PK04_107268 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N17 compound treatment 8771840.0 -1110000.0 -0.95 9522280.0 -580000.0 -0.48 9454480.0 -476176.77419355 -0.40040736036519 -1.0585 -0.9291 3189686 PK04_107269 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cc4ccccc4o3)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N18 compound treatment 9724160.0 -154000.0 -0.13 9931160.0 -171000.0 -0.14 8967760.0 -962896.77419355 -0.80968030478169 -0.6258 -0.7516 3071337 PK04_107270 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N19 compound treatment 9186000.0 -692000.0 -0.6 9876400.0 -226000.0 -0.19 8956400.0 -974256.77419355 -0.819232697632963 -0.9249 -0.898 3189687 PK04_107271 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N20 compound treatment 9764480.0 -113000.0 -0.1 9122280.0 -980000.0 -0.81 8983920.0 -946736.77419355 -0.796091689598894 -0.9853 -0.8628 3189688 PK04_107272 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N21 compound treatment 9402840.0 -475000.0 -0.41 9951640.0 -151000.0 -0.12 9003080.0 -927576.77419355 -0.779980435458895 -0.7585 -0.8527 3071339 PK04_107273 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N22 compound treatment 8864880.0 -1010000.0 -0.87 9075000.0 -1030000.0 -0.85 8415640.0 -1515016.77419355 -1.2739467784652 -1.7308 -0.9816 3189689 PK04_107274 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N23 compound treatment 8742360.0 -1140000.0 -0.98 9816560.0 -286000.0 -0.24 8465400.0 -1465256.77419355 -1.23210460696174 -1.4124 -0.8881 3189690 PK04_107275 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 N24 compound treatment 7939280.0 -1940000.0 -1.67 7906960.0 -2200000.0 -1.82 7653480.0 -2277176.77419355 -1.91483161433897 -3.1202 -0.9984 3071341 PK04_107276 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O01 compound treatment 7854480.0 -2020000.0 -1.74 7459760.0 -2640000.0 -2.19 8096080.0 -1834576.77419355 -1.54265828018639 -3.1617 -0.9891 3414059 PK04_107277 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(Cc5ccccc5)C2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O02 compound treatment 7752000.0 -2130000.0 -1.83 8599680.0 -1500000.0 -1.25 8468960.0 -1461696.77419355 -1.22911107539919 -2.4856 -0.9816 3189692 PK04_107278 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O03 compound treatment 8727320.0 -1150000.0 -0.99 9095320.0 -1010000.0 -0.84 8839720.0 -1090936.77419355 -0.917346535475084 -1.5836 -0.9976 3414060 PK04_107279 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(nn4)C5(CCCCC5)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O04 compound treatment 9089000.0 -789000.0 -0.68 9490280.0 -612000.0 -0.51 9227400.0 -703256.77419355 -0.591354311832355 -1.0265 -0.9931 3189693 PK04_107280 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O05 compound treatment 8883960.0 -994000.0 -0.86 9259840.0 -842000.0 -0.7 8518040.0 -1412616.77419355 -1.18784070205936 -1.5831 -0.976 3071393 PK04_107281 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cnnn3C[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O06 compound treatment 9213320.0 -665000.0 -0.57 9881520.0 -221000.0 -0.18 8947960.0 -982696.77419355 -0.826329721899225 -0.913 -0.8938 3189694 PK04_107282 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O07 compound treatment 9289240.0 -589000.0 -0.51 9882840.0 -219000.0 -0.18 9794360.0 -136296.77419355 -0.114609184107218 -0.4637 -0.8426 3189695 PK04_107283 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O08 compound treatment 9683800.0 -194000.0 -0.17 9176840.0 -925000.0 -0.77 9332000.0 -598656.77419355 -0.503398300191235 -0.8303 -0.8898 3071395 PK04_107284 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O09 compound treatment 1.037396E7 496000.0 0.43 9915360.0 -187000.0 -0.16 9470000.0 -460656.77419355 -0.38735690815993 -0.0666 -0.1116 3189696 PK04_107285 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O10 compound treatment 9807120.0 -70700.0 -0.06 9487400.0 -615000.0 -0.51 9367400.0 -563256.77419355 -0.473631160496248 -0.6031 -0.8631 3189697 PK04_107286 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O11 mock treatment 9561200.0 -317000.0 -0.27 9732200.0 -370000.0 -0.31 9920480.0 -10176.7741935495 -0.00855744234643301 -0.3395 -0.8269 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O12 mock treatment 9787360.0 -90500.0 -0.08 1.0009E7 -93200.0 -0.08 9872680.0 -57976.7741935495 -0.0487514897311896 -0.1178 -0.9806 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O13 compound treatment 9981880.0 104000.0 0.09 9945920.0 -156000.0 -0.13 9195720.0 -734936.77419355 -0.617993379220412 -0.38 -0.5958 3071396 PK04_107287 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](C)NC2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O14 compound treatment 9367640.0 -510000.0 -0.44 9179280.0 -923000.0 -0.77 9271200.0 -659456.77419355 -0.554523783057202 -1.0157 -0.9744 3187592 PK04_107288 CC(C)[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O15 compound treatment 9255000.0 -623000.0 -0.54 9624080.0 -478000.0 -0.4 1.033288E7 402223.22580645 0.338221326303643 -0.3432 -0.459 3187593 PK04_107289 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](Cc5ccccc5)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O16 compound treatment 9448080.0 -430000.0 -0.37 9179320.0 -923000.0 -0.77 9321480.0 -609176.77419355 -0.512244354134491 -0.9513 -0.9584 3071397 PK04_107290 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O17 compound treatment 8758440.0 -1120000.0 -0.96 9910280.0 -192000.0 -0.16 8978080.0 -952576.77419355 -0.801002426768914 -1.1106 -0.8794 3187594 PK04_107291 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O18 compound treatment 9330280.0 -548000.0 -0.47 9992080.0 -110000.0 -0.09 9350920.0 -579736.77419355 -0.487488857167813 -0.6063 -0.8862 3071398 PK04_107292 CC(C)[Si](O[C@H](C)c1cn(Cc2ccccc2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O19 compound treatment 1.032884E7 451000.0 0.39 8982000.0 -1120000.0 -0.93 9331040.0 -599616.77419355 -0.50420554465754 -0.6035 -0.5359 3187595 PK04_107293 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](NC2=O)C(C)C)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O20 compound treatment 9247440.0 -630000.0 -0.54 9594080.0 -508000.0 -0.42 9475240.0 -455416.77419355 -0.38295069878135 -0.7777 -0.9887 3071399 PK04_107294 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O21 compound treatment 9368960.0 -509000.0 -0.44 9570760.0 -531000.0 -0.44 9394680.0 -535976.77419355 -0.450691963578755 -0.7676 -0.9999 3187594 PK04_107295 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O22 compound treatment 9132560.0 -745000.0 -0.64 9636440.0 -466000.0 -0.39 8337880.0 -1592776.77419355 -1.33933358023588 -1.3667 -0.8907 3187596 PK04_107296 CC(C)[Si](O[C@H](C)c1cn(Cc2cccc(Cl)c2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O23 compound treatment 8997160.0 -881000.0 -0.76 9037240.0 -1060000.0 -0.88 8741960.0 -1188696.77419355 -0.999550930293783 -1.5248 -0.9938 3187597 PK04_107297 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](NC2=O)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 O24 compound treatment 7542520.0 -2340000.0 -2.01 7139680.0 -2960000.0 -2.46 7311280.0 -2619376.77419355 -2.20258063139051 -3.851 -0.9966 3071400 PK04_107298 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](C)c2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P01 compound treatment 5960680.0 -3920000.0 -3.37 6322400.0 -3780000.0 -3.14 6979520.0 -2951136.77419355 -2.48155086487099 -5.1895 -0.9922 3187598 PK04_107299 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cc3ccccc3o2)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P02 compound treatment 7532880.0 -2340000.0 -2.02 7915640.0 -2190000.0 -1.81 8106520.0 -1824136.77419355 -1.53387949661533 -3.098 -0.9939 3071401 PK04_107300 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P03 compound treatment 8135120.0 -1740000.0 -1.5 7880760.0 -2220000.0 -1.84 7922760.0 -2007896.77419355 -1.68839954154049 -2.9047 -0.9965 3187599 PK04_107301 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3cccc4ccccc34)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P04 compound treatment 8400920.0 -1480000.0 -1.27 8807840.0 -1290000.0 -1.07 8565560.0 -1365096.77419355 -1.14788210097728 -2.0165 -0.9976 3187600 PK04_107302 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P05 compound treatment 7723880.0 -2150000.0 -1.85 8718400.0 -1380000.0 -1.15 8831800.0 -1098856.77419355 -0.924006302322098 -2.2665 -0.9571 3071402 PK04_107303 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P06 compound treatment 9114960.0 -763000.0 -0.66 1.290724E7 2810000.0 2.33 8857800.0 -1072856.77419355 -0.902143431359678 0.4436 0.1719 3187601 PK04_107304 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P07 compound treatment 8533960.0 -1340000.0 -1.16 8944600.0 -1160000.0 -0.96 8215840.0 -1714816.77419355 -1.44195453301487 -2.0547 -0.9864 3187602 PK04_107305 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P08 compound treatment 8309680.0 -1570000.0 -1.35 8468520.0 -1630000.0 -1.36 8779800.0 -1150856.77419355 -0.967732044246938 -2.1204 -0.9892 3071403 PK04_107306 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P09 compound treatment 8455560.0 -1420000.0 -1.22 9039240.0 -1060000.0 -0.88 8242560.0 -1688096.77419355 -1.41948622870273 -2.0354 -0.9826 3187603 PK04_107307 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P10 compound treatment 8907520.0 -970000.0 -0.84 8734480.0 -1370000.0 -1.13 8052520.0 -1878136.77419355 -1.57928699784497 -2.049 -0.9682 3187604 PK04_107308 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P11 mock treatment 8881760.0 -996000.0 -0.86 8995400.0 -1110000.0 -0.92 8625680.0 -1304976.77419355 -1.09732841627494 -1.6586 -0.9944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P12 mock treatment 8266640.0 -1610000.0 -1.39 8967400.0 -1130000.0 -0.94 8903440.0 -1027216.77419355 -0.863765684024107 -1.8428 -0.9773 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P13 compound treatment 8387520.0 -1490000.0 -1.28 8074080.0 -2030000.0 -1.68 7494680.0 -2435976.77419355 -2.04836330314021 -2.8945 -0.9829 3071404 PK04_107309 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2cccc3ccccc23)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P14 compound treatment 8302760.0 -1580000.0 -1.36 9360240.0 -742000.0 -0.62 8260240.0 -1670416.77419355 -1.40461947644828 -1.949 -0.9522 3187605 PK04_107310 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P15 compound treatment 8800760.0 -1080000.0 -0.93 9173480.0 -929000.0 -0.77 8602480.0 -1328176.77419355 -1.11683682421064 -1.6248 -0.9888 3187606 PK04_107311 COc1ccc(CC(=O)N2[C@H](C(CC=C)OC(=O)C)[C@@H](N(Cc3ccc(cc3)c4ccccc4)C(=O)c5ccc(C)cc5)c6cc(OCCCO)ccc26)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P16 compound treatment 8696280.0 -1180000.0 -1.02 8926640.0 -1180000.0 -0.98 9015680.0 -914976.77419355 -0.769385351838645 -1.5944 -0.9932 3071405 PK04_107312 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P17 compound treatment 8626840.0 -1250000.0 -1.08 8745920.0 -1360000.0 -1.13 8564640.0 -1366016.77419355 -1.14865571025749 -1.9344 -0.9996 3187607 PK04_107313 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P18 compound treatment 8931920.0 -946000.0 -0.81 8709760.0 -1390000.0 -1.16 8587600.0 -1343056.77419355 -1.12934911343836 -1.789 -0.9889 3187608 PK04_107314 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P19 compound treatment 8307800.0 -1570000.0 -1.35 8664440.0 -1440000.0 -1.19 8412720.0 -1517936.77419355 -1.27640214705021 -2.2057 -0.9987 3187728 PK04_107315 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc7ccccc7c6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P20 compound treatment 8607520.0 -1270000.0 -1.09 8380600.0 -1720000.0 -1.43 7433240.0 -2497416.77419355 -2.10002694898371 -2.6682 -0.965 3071452 PK04_107316 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P21 compound treatment 8626720.0 -1250000.0 -1.08 8349040.0 -1750000.0 -1.45 8279480.0 -1651176.77419355 -1.38844095193609 -2.263 -0.9921 3187729 PK04_107317 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P22 compound treatment 8118920.0 -1760000.0 -1.51 8413080.0 -1690000.0 -1.4 8263240.0 -1667416.77419355 -1.40209683749108 -2.4925 -0.9993 3187730 PK04_107318 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P23 compound treatment 7454760.0 -2420000.0 -2.09 7461520.0 -2640000.0 -2.19 7103760.0 -2826896.77419355 -2.37707997685672 -3.8412 -0.9985 3071453 PK04_107319 CC(=O)OC(CC=C)[C@@H]1[C@@H](N(Cc2ccc(cc2)c3ccccc3)C(=O)c4ccc(C)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc(cc6)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2107 P24 compound treatment 4614000.0 -5260000.0 -4.53 4667040.0 -5440000.0 -4.51 5217760.0 -4712896.77419355 -3.96297900128456 -7.5068 -0.9982 3187731 PK04_107320 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A01 compound treatment 6861280.0 -3410000.0 -2.94 6698000.0 -2900000.0 -2.4 7122400.0 -2861322.53968254 -2.40602790257473 -4.4703 -0.9953 3187732 PK04_108001 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A02 compound treatment 7707920.0 -2560000.0 -2.21 7114840.0 -2480000.0 -2.06 7042440.0 -2941282.53968254 -2.47326463958069 -3.8888 -0.9971 3071454 PK04_108002 CCC1=C2CN(Cc3ccccc3Br)[C@@H]([C@@H](O)Cc4ccccc4)C2C=CCC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A03 compound treatment 7606520.0 -2670000.0 -2.29 7894560.0 -1700000.0 -1.41 7413640.0 -2570082.53968254 -2.16113011260953 -3.3855 -0.9807 3187733 PK04_108003 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A04 compound treatment 7511760.0 -2760000.0 -2.38 7769960.0 -1820000.0 -1.51 8510080.0 -1473642.53968254 -1.23915602653123 -2.96 -0.9621 3071455 PK04_108004 CCC1=C2CN(Cc3ccccc3)[C@H](C2C=CCC1)C(=O)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A05 compound treatment 8396960.0 -1870000.0 -1.61 7927160.0 -1670000.0 -1.38 7904560.0 -2079162.53968254 -1.74832547365295 -2.7388 -0.9955 3187734 PK04_108005 CCOC(=O)C[C@H]1[C@H](OC(=O)Cc2ccc3OCOc3c2)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A06 compound treatment 8045560.0 -2230000.0 -1.92 6916720.0 -2680000.0 -2.22 7660960.0 -2322762.53968254 -1.95316375697777 -3.5156 -0.9978 3071456 PK04_108006 C/C=C\[C@@H](NCc1ccccc1Br)[C@@H](O)Cc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A07 compound treatment 8862880.0 -1410000.0 -1.21 8241440.0 -1350000.0 -1.12 8180160.0 -1803562.53968254 -1.51657904145129 -2.223 -0.9914 3187735 PK04_108007 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A08 compound treatment 8245720.0 -2030000.0 -1.74 8222520.0 -1370000.0 -1.14 8112400.0 -1871322.53968254 -1.57355704669797 -2.5716 -0.9855 3071457 PK04_108008 CC(=CCN[C@H](CO)c1ccccc1)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A09 compound treatment 8907480.0 -1360000.0 -1.17 8221480.0 -1370000.0 -1.14 8694680.0 -1289042.53968254 -1.08392964269805 -1.9606 -0.9995 3187736 PK04_108009 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A10 compound treatment 8814960.0 -1460000.0 -1.25 8189960.0 -1400000.0 -1.16 8542280.0 -1441442.53968254 -1.21207970172393 -2.0956 -0.9995 3071458 PK04_108010 CC(=CCN(CC#C)[C@H](CO)c1ccccc1)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A11 compound treatment 8800120.0 -1470000.0 -1.27 8485880.0 -1110000.0 -0.92 8929720.0 -1054002.53968254 -0.886289289197777 -1.7732 -0.9862 3071459 PK04_108011 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A12 compound treatment 3670240.0 -6600000.0 -5.68 3554080.0 -6040000.0 -5.01 3620160.0 -6363562.53968254 -5.35099025639878 -9.262 -0.9987 3187737 PK04_108012 CC(=CCN(CC#Cc1ccccc1)[C@H](CO)c2ccccc2)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A13 mock treatment 9007200.0 -1260000.0 -1.09 8771160.0 -822000.0 -0.68 8822840.0 -1160882.53968254 -0.976162506446371 -1.5855 -0.9829 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A14 mock treatment 9110840.0 -1160000.0 -1.0 8478160.0 -1110000.0 -0.92 9060480.0 -923242.539682539 -0.776335865849853 -1.559 -0.9947 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A15 compound treatment 9062400.0 -1210000.0 -1.04 8523880.0 -1070000.0 -0.89 9237240.0 -746482.539682539 -0.627701978491494 -1.4753 -0.9806 3187738 PK04_108013 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A16 compound treatment 9128640.0 -1140000.0 -0.98 8211080.0 -1380000.0 -1.15 8805480.0 -1178242.53968254 -0.990760177212048 -1.8019 -0.9974 3071460 PK04_108014 O=C1OC[C@@H](c2ccccc2)n3cc(/C=C/c4ccccc4)cc13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A17 compound treatment 9420360.0 -851000.0 -0.73 8876920.0 -716000.0 -0.59 9228920.0 -754802.539682539 -0.634698097199468 -1.1324 -0.9961 3187739 PK04_108015 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A18 compound treatment 8869920.0 -1400000.0 -1.21 8360240.0 -1230000.0 -1.02 8844480.0 -1139242.53968254 -0.957965870768418 -1.84 -0.9951 3071461 PK04_108016 CC(=C)C/1CN([C@H](CO)c2ccccc2)C(=O)\C1=C/c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A19 compound treatment 8561040.0 -1710000.0 -1.47 8449800.0 -1140000.0 -0.95 8997720.0 -986002.539682539 -0.829109472834525 -1.8762 -0.9683 3187740 PK04_108017 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A20 compound treatment 9202920.0 -1070000.0 -0.92 8470360.0 -1120000.0 -0.93 8769720.0 -1214002.53968254 -1.0208300335819 -1.6581 -0.9989 3071462 PK04_108018 OCC(/C=C/c1ccccc1)N(CC#C)C(C(=O)O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A21 compound treatment 8918800.0 -1350000.0 -1.16 7972440.0 -1620000.0 -1.34 7942360.0 -2041362.53968254 -1.7165402227922 -2.4395 -0.9869 3187741 PK04_108019 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A22 compound treatment 8146280.0 -2130000.0 -1.83 7499800.0 -2090000.0 -1.74 8188360.0 -1795362.53968254 -1.50968382830161 -2.9303 -0.9969 3071463 PK04_108020 C/C=C/CN([C@H](CO[Si](C)(C)C(C)(C)C)c1ccccc1)C(=O)C#Cc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A23 compound treatment 8110480.0 -2160000.0 -1.86 8089480.0 -1500000.0 -1.25 1.011692E7 133197.460317461 0.112003034132411 -1.7293 -0.7712 3187742 PK04_108021 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 A24 compound treatment 6043160.0 -4230000.0 -3.64 6384040.0 -3210000.0 -2.66 6465400.0 -3518322.53968254 -2.95848583420203 -5.3461 -0.9913 3071464 PK04_108022 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B01 compound treatment 8338320.0 -1930000.0 -1.66 8172560.0 -1420000.0 -1.18 8354920.0 -1628802.53968254 -1.36962691339774 -2.4318 -0.99 2133065 PK04_108023 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(C3CCCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B02 compound treatment 9432920.0 -839000.0 -0.72 8774760.0 -818000.0 -0.68 9255960.0 -727762.539682539 -0.611960711398552 -1.162 -0.9977 3071465 PK04_108024 CCCCNC(=O)c1ccc(C#CC(C)(C)C)c(OC(=O)C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B03 compound treatment 9246840.0 -1020000.0 -0.88 9109880.0 -483000.0 -0.4 9833920.0 -149802.539682539 -0.125965907497005 -0.8134 -0.8325 2133224 PK04_108025 CCCCC(=O)N(Cc1ccccc1F)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B04 compound treatment 1.058816E7 316000.0 0.27 9124040.0 -469000.0 -0.39 9009080.0 -974642.539682539 -0.819557079983253 -0.5405 -0.5707 1952196 PK04_108026 CCCCNC(=O)c1ccc(C#C[Si](C)(C)C)c(OC(=O)C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B05 compound treatment 9207520.0 -1060000.0 -0.92 8915240.0 -678000.0 -0.56 9753600.0 -230122.539682539 -0.193505361177835 -0.9651 -0.8838 2133510 PK04_108027 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCc3cccc(F)c3)C(=O)CCC4CCCC4)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B06 compound treatment 9404720.0 -867000.0 -0.75 9425080.0 -168000.0 -0.14 1.011432E7 130597.460317461 0.109816747036169 -0.4478 -0.5839 3071510 PK04_108028 CCCCNC(=O)c1ccc(C#C[Si](C(C)C)(C(C)C)C(C)C)c(OC(=O)C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B07 compound treatment 1.025512E7 -16600.0 -0.01 9483080.0 -110000.0 -0.09 9612840.0 -370882.539682539 -0.311867581049767 -0.2409 -0.7408 2128988 PK04_108029 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H]3O[C@@H]32)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B08 compound treatment 9030160.0 -1240000.0 -1.07 8757680.0 -835000.0 -0.69 9117360.0 -866362.539682539 -0.728506631221298 -1.4376 -0.9798 3187870 PK04_108030 COC(=O)C[C@H]1O[C@@H](CCc2ccccc2)[C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B09 compound treatment 1.036976E7 98100.0 0.08 9448360.0 -145000.0 -0.12 9519520.0 -464202.539682539 -0.390338470211806 -0.2459 -0.5897 3187871 PK04_108031 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)N(Cc3ccco3)C(=O)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B10 compound treatment 1.006184E7 -210000.0 -0.18 9560480.0 -32500.0 -0.03 1.004964E7 65917.4603174608 0.0554286511188877 -0.0878 -0.4603 3071511 PK04_108032 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(I)cc52 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B11 compound treatment 1.034284E7 71200.0 0.06 9015440.0 -578000.0 -0.48 9800080.0 -183642.539682539 -0.154421274934247 -0.3304 -0.6516 2129008 PK04_108033 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)NCc3ccc(F)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B12 compound treatment 9527000.0 -745000.0 -0.64 9035840.0 -557000.0 -0.46 9540120.0 -443602.539682539 -0.37301634937235 -0.8522 -0.9753 3187872 PK04_108034 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc52 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B13 mock treatment 1.011232E7 -159000.0 -0.14 9982880.0 390000.0 0.32 9876200.0 -107522.539682539 -0.090413515793501 0.0553 0.1526 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B14 mock treatment 1.059884E7 327000.0 0.28 9020880.0 -572000.0 -0.47 9652120.0 -331602.539682539 -0.278837828303464 -0.2724 -0.4406 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B15 compound treatment 1.160496E7 1330000.0 1.15 9452000.0 -141000.0 -0.12 9352200.0 -631522.539682539 -0.531034453651502 0.2884 0.2271 3187873 PK04_108035 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CCC\C=C\CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B16 compound treatment 1.04068E7 135000.0 0.12 9203560.0 -389000.0 -0.32 9897560.0 -86162.5396825392 -0.0724523264182207 -0.1612 -0.4594 3414061 PK04_108036 COC(=O)C[C@@H]1C[C@H](C)[C@]2(O1)C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B17 compound treatment 1.010436E7 -167000.0 -0.14 9453280.0 -140000.0 -0.12 9945800.0 -37922.5396825392 -0.0318882919864078 -0.1685 -0.8981 3187874 PK04_108037 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CCC\C=C\CNC(=O)[C@@H](Cc5ccccc5)NC(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B18 compound treatment 9689240.0 -582000.0 -0.5 9660880.0 67900.0 0.06 1.00436E7 59877.4603174608 0.0503497380183871 -0.2278 -0.4494 3071513 PK04_108038 CC(C)[Si](OCC[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)O)C(=O)N(Cc3ccccc3)c4ccccc42)(C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B19 compound treatment 9999080.0 -273000.0 -0.23 9439640.0 -153000.0 -0.13 9061680.0 -922042.539682539 -0.775326810266972 -0.6565 -0.8007 3187875 PK04_108039 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CCC\C=C\CNC(=O)[C@@H]5CCCN5C(=O)CNC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B20 compound treatment 8882080.0 -1390000.0 -1.2 8286320.0 -1310000.0 -1.08 8725440.0 -1258282.53968254 -1.05806418459021 -1.9272 -0.9986 3071514 PK04_108040 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccccc53 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B21 compound treatment 9777120.0 -495000.0 -0.43 9189960.0 -403000.0 -0.33 9829960.0 -153762.539682539 -0.129295790920512 -0.5134 -0.9226 3187876 PK04_108041 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/CC\C=C\CNC(=O)[C@@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B22 compound treatment 7702400.0 -2570000.0 -2.21 7777760.0 -1820000.0 -1.51 8521440.0 -1462282.53968254 -1.22960363367996 -2.856 -0.97 3071515 PK04_108042 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(C)cc3)C(=O)N(C)c4ccccc42 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B23 compound treatment 8760600.0 -1510000.0 -1.3 8451840.0 -1140000.0 -0.95 8788880.0 -1194842.53968254 -1.0047187794419 -1.8775 -0.9899 3187877 PK04_108043 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC(=O)[C@@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 B24 compound treatment 7302960.0 -2970000.0 -2.55 7088600.0 -2500000.0 -2.08 6620480.0 -3363242.53968254 -2.82808221770772 -4.3074 -0.9923 3071516 PK04_108044 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(C)c4ccccc42 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C01 compound treatment 9022280.0 -1250000.0 -1.08 8216720.0 -1380000.0 -1.14 8784000.0 -1199722.53968254 -1.00882227214562 -1.8624 -0.9987 3187878 PK04_108045 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C02 compound treatment 8925440.0 -1350000.0 -1.16 8827120.0 -766000.0 -0.64 8819440.0 -1164282.53968254 -0.979021497264534 -1.601 -0.9735 3071464 PK04_108046 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C03 compound treatment 9374320.0 -897000.0 -0.77 9313080.0 -280000.0 -0.23 9744480.0 -239242.539682539 -0.20117418360773 -0.6961 -0.8375 3187879 PK04_108047 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C04 compound treatment 9830720.0 -441000.0 -0.38 9728320.0 135000.0 0.11 9931280.0 -52442.5396825392 -0.0440978645392669 -0.1798 -0.4514 3071517 PK04_108048 CC(=C)C1C(=C)CN([C@H](CO)c2ccccc2)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C05 compound treatment 1.054924E7 278000.0 0.24 9524840.0 -68200.0 -0.06 9619360.0 -364362.539682539 -0.306385045716114 -0.0716 -0.1824 3071518 PK04_108049 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C06 compound treatment 1.014676E7 -125000.0 -0.11 9810320.0 217000.0 0.18 1.021804E7 234317.460317461 0.197032784583177 0.1558 0.5411 3187880 PK04_108050 CC(C)(C)OC(=O)N(CC#C)[C@H](CO)c1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C07 compound treatment 1.012712E7 -145000.0 -0.12 9404160.0 -189000.0 -0.16 9774040.0 -209682.539682539 -0.176317781082763 -0.2641 -0.9903 3187881 PK04_108051 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C08 compound treatment 5691560.0 -4580000.0 -3.94 4244280.0 -5350000.0 -4.44 4056920.0 -5926802.53968254 -4.98372765941623 -7.715 -0.9955 3071519 PK04_108052 CC(=CCN([C@H](CO)c1ccccc1)C(=O)C#Cc2ccccc2)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C09 compound treatment 1.019756E7 -74100.0 -0.06 9289040.0 -304000.0 -0.25 9901200.0 -82522.5396825392 -0.0693915244834819 -0.2225 -0.8264 3187882 PK04_108053 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C10 compound treatment 9290880.0 -981000.0 -0.84 7859400.0 -1730000.0 -1.44 8956240.0 -1027482.53968254 -0.863989160816109 -1.8165 -0.9672 3071520 PK04_108054 OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C11 mock treatment 1.060368E7 332000.0 0.29 9759360.0 166000.0 0.14 1.032388E7 340157.460317461 0.286031486993274 0.4098 0.9592 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C12 mock treatment 1.101016E7 738000.0 0.64 9872960.0 280000.0 0.23 1.059508E7 611357.460317461 0.514078048724361 0.7978 0.9388 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C13 compound treatment 1.044536E7 174000.0 0.15 1.028724E7 694000.0 0.58 1.071816E7 734437.460317461 0.617573516341847 0.7754 0.9041 3187883 PK04_108055 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C14 compound treatment 9880760.0 -391000.0 -0.34 9996800.0 404000.0 0.33 1.043656E7 452837.460317461 0.380781806225792 0.219 0.3598 3071521 PK04_108056 CC(C)(C)[Si](C)(C)OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C15 mock treatment 9901280.0 -370000.0 -0.32 9789280.0 196000.0 0.16 9850400.0 -133322.539682539 -0.112108210825441 -0.1548 -0.4126 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C16 mock treatment 1.013836E7 -133000.0 -0.11 9452720.0 -140000.0 -0.12 1.024404E7 260317.460317461 0.218895655545596 -0.0071 -0.0258 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C17 compound treatment 1.039176E7 120000.0 0.1 1.010028E7 507000.0 0.42 9958520.0 -25202.5396825392 -0.02119230280787 0.2904 0.6693 3188001 PK04_108057 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C18 compound treatment 1.025604E7 -15600.0 -0.01 9501160.0 -91900.0 -0.08 9931080.0 -52642.5396825392 -0.044266040469747 -0.0773 -0.8674 3071522 PK04_108058 O=C1OC[C@H](N2CC(=CC21)/C=C/c3ccccc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C19 compound treatment 1.046836E7 197000.0 0.17 9659680.0 66700.0 0.06 1.009872E7 114997.460317461 0.0966990244587172 0.1855 0.9154 3188002 PK04_108059 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C20 compound treatment 9912800.0 -359000.0 -0.31 9078760.0 -514000.0 -0.43 9365560.0 -618162.539682539 -0.519800301495428 -0.7247 -0.9794 3071523 PK04_108060 OCC(/C=C/c1ccccc1)N(CC#C)Cc2ccccc2Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C21 compound treatment 1.043728E7 166000.0 0.14 9618600.0 25600.0 0.02 9840800.0 -142922.539682539 -0.120180655488488 0.0252 0.1341 3188003 PK04_108061 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C22 compound treatment 9922080.0 -350000.0 -0.3 9131840.0 -461000.0 -0.38 9586520.0 -397202.539682539 -0.333999533500955 -0.5874 -0.9951 3071524 PK04_108062 OCC1C=C(CN1Cc2ccccc2Br)/C=C/c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C23 compound treatment 8708720.0 -1560000.0 -1.35 8989720.0 -603000.0 -0.5 8863200.0 -1120522.53968254 -0.942224603675476 -1.6096 -0.9375 3188004 PK04_108063 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 C24 compound treatment 8424880.0 -1850000.0 -1.59 8441960.0 -1150000.0 -0.95 7844440.0 -2139282.53968254 -1.79887915835528 -2.5075 -0.9706 3071525 PK04_108064 CCOC(=O)C1OC[C@H](N1CC#C)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D01 compound treatment 8157760.0 -2110000.0 -1.82 7255720.0 -2340000.0 -1.94 7519040.0 -2464682.53968254 -2.07250139724649 -3.3664 -0.9986 3188005 PK04_108065 CC(C)C[C@@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D02 compound treatment 8363160.0 -1910000.0 -1.64 8492480.0 -1100000.0 -0.91 8439600.0 -1544122.53968254 -1.29842122443244 -2.2251 -0.9741 3414062 PK04_108066 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccccc3)C(=O)N(C)c4ccccc42 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D03 compound treatment 9453760.0 -818000.0 -0.7 9551360.0 -41700.0 -0.03 9733600.0 -250122.539682539 -0.21032295422585 -0.5478 -0.7448 3188006 PK04_108067 CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D04 compound treatment 1.096876E7 697000.0 0.6 9599200.0 6190.0 0.01 1.021736E7 233637.460317461 0.196460986419544 0.4628 0.733 3071527 PK04_108068 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D05 compound treatment 1.0776E7 504000.0 0.43 9704240.0 111000.0 0.09 9572760.0 -410962.539682539 -0.345570037517989 0.1043 0.1855 3188007 PK04_108069 CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D06 compound treatment 9778760.0 -493000.0 -0.42 9528480.0 -64500.0 -0.05 9696600.0 -287122.539682539 -0.241435501364678 -0.4152 -0.8456 3071528 PK04_108070 CCOC(=O)[C@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@@H]2O[Si](C)(C)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D07 compound treatment 9919560.0 -352000.0 -0.3 9888160.0 295000.0 0.24 9790360.0 -193362.539682539 -0.162594625155583 -0.1275 -0.302 3188008 PK04_108071 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CC\C=C\CNC(=O)[C@@H]5CCCN5C(=O)[C@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D08 compound treatment 1.072736E7 456000.0 0.39 1.008304E7 490000.0 0.41 1.003416E7 50437.4603174608 0.0424118340997238 0.4856 0.8573 3071529 PK04_108072 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D09 compound treatment 9968640.0 -303000.0 -0.26 9534680.0 -58300.0 -0.05 1.022496E7 241237.460317461 0.20285167177779 -0.0614 -0.1839 3188009 PK04_108073 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)CNC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D10 compound treatment 1.047872E7 207000.0 0.18 1.006988E7 477000.0 0.4 1.039516E7 411437.460317461 0.3459693886164 0.531 0.9569 3071530 PK04_108074 CCOC(=O)[C@H]1C[C@H]2O[C@]32C[C@H]1C(=O)N4CCCC4[C@@H]3O[Si](C)(C)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D11 mock treatment 1.053744E7 266000.0 0.23 9934400.0 341000.0 0.28 1.054456E7 560837.460317461 0.471596808685074 0.5678 0.9531 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D12 mock treatment 1.083164E7 560000.0 0.48 1.010984E7 517000.0 0.43 1.061692E7 633197.460317461 0.532442860332794 0.8332 0.9961 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D13 compound treatment 1.072724E7 456000.0 0.39 1.041092E7 818000.0 0.68 1.072012E7 736397.460317461 0.619221640460553 0.9756 0.9768 3188010 PK04_108075 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D14 compound treatment 1.044868E7 177000.0 0.15 1.023416E7 641000.0 0.53 1.03718E7 388077.460317461 0.326326439936318 0.5834 0.9083 3071531 PK04_108076 CCOC(=O)[C@@H]1[C@@H]2CN(CCC2=C[C@@H]3[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]4CCCN4C(=O)[C@@H]13)S(=O)(=O)c5ccc(C)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D15 mock treatment 1.067928E7 408000.0 0.35 9510240.0 -82800.0 -0.07 9569080.0 -414642.539682539 -0.348664474638824 -0.0384 -0.0769 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D16 mock treatment 1.099024E7 719000.0 0.62 1.019148E7 598000.0 0.5 1.01498E7 166077.460317461 0.139651157103348 0.7243 0.8995 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D17 compound treatment 1.054752E7 276000.0 0.24 1.035284E7 760000.0 0.63 1.027248E7 288757.460317461 0.242810272859874 0.6412 0.8955 3071578 PK04_108077 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D18 compound treatment 8279200.0 -1990000.0 -1.71 7894000.0 -1700000.0 -1.41 8267760.0 -1715962.53968254 -1.44291798390099 -2.6369 -0.996 3071579 PK04_108078 O=C1C=C(C(=O)C2=C1CC(=CC2)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D19 compound treatment 1.024508E7 -26600.0 -0.02 1.010876E7 516000.0 0.43 9510240.0 -473482.539682539 -0.398141833386085 0.0039 0.0067 3071580 PK04_108079 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc6ccccc6)NC2=O)[C@@H]7O[C@]7(C)[C@H]4C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D20 compound treatment 8172360.0 -2100000.0 -1.81 7999960.0 -1590000.0 -1.32 8192800.0 -1790922.53968254 -1.50595032264495 -2.6756 -0.9917 3188011 PK04_108080 O=C1C=C(C(=O)c2ccc(cc12)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D21 compound treatment 9806200.0 -465000.0 -0.4 9603240.0 10200.0 0.01 9372360.0 -611362.539682539 -0.514082319859103 -0.5232 -0.8027 3188012 PK04_108081 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D22 compound treatment 9159160.0 -1110000.0 -0.96 8585720.0 -1010000.0 -0.84 9184360.0 -799362.539682539 -0.672167694510446 -1.4233 -0.99 3071581 PK04_108082 O=C1C2CC=C(CC2C(=O)c3ccccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D23 compound treatment 9166560.0 -1110000.0 -0.95 9181000.0 -412000.0 -0.34 9352320.0 -631402.539682539 -0.530933548093214 -1.053 -0.9224 3188013 PK04_108083 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 D24 compound treatment 7703960.0 -2570000.0 -2.21 7799080.0 -1790000.0 -1.49 7887720.0 -2096002.53968254 -1.76248588699937 -3.1527 -0.9869 3071582 PK04_108084 O=C1c2ccccc2C(=O)c3cc(ccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E01 mock treatment 9619840.0 -652000.0 -0.56 8170960.0 -1420000.0 -1.18 8852840.0 -1130882.53968254 -0.950936116874348 -1.554 -0.9618 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E02 mock treatment 9852000.0 -420000.0 -0.36 8990120.0 -603000.0 -0.5 9590320.0 -393402.539682539 -0.330804190821832 -0.6883 -0.9832 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E03 compound treatment 9722680.0 -549000.0 -0.47 9598600.0 5590.0 0.0 1.017368E7 189957.460317461 0.159731363202679 -0.1779 -0.3567 3188014 PK04_108085 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E04 compound treatment 9920120.0 -352000.0 -0.3 9788040.0 195000.0 0.16 9409760.0 -573962.539682539 -0.482633420859314 -0.3599 -0.6078 3071583 PK04_108086 C/C=C/CN([C@H](CO)c1ccccc1)C(=O)C#Cc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E05 compound treatment 9517960.0 -754000.0 -0.65 8472760.0 -1120000.0 -0.93 9374280.0 -609442.539682539 -0.512467830926493 -1.2069 -0.9704 3188015 PK04_108087 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E06 compound treatment 1.052328E7 252000.0 0.22 9691120.0 98100.0 0.08 1.002556E7 41837.4603174608 0.0351802690890773 0.1923 0.8219 3071584 PK04_108088 OCC(NCC#C)/C=C/c1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E07 compound treatment 1.134536E7 1070000.0 0.92 9715160.0 122000.0 0.1 1.02676E7 283877.460317461 0.238706780156158 0.7298 0.7604 3188129 PK04_108089 CCOC(=O)C[C@H]1[C@H](OC(=O)c2cc3ccccc3oc2=O)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E08 compound treatment 1.02334E7 -38300.0 -0.03 1.011316E7 520000.0 0.43 1.047976E7 496037.460317461 0.417107807209505 0.4709 0.7835 3071585 PK04_108090 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E09 mock treatment 1.047636E7 205000.0 0.18 1.004772E7 455000.0 0.38 1.039872E7 414997.460317461 0.348962920178947 0.521 0.959 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E10 mock treatment 1.06562E7 385000.0 0.33 9735920.0 143000.0 0.12 1.098E7 996277.460317461 0.837749444526464 0.7432 0.818 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E11 compound treatment 1.044776E7 176000.0 0.15 9883440.0 290000.0 0.24 1.035428E7 370557.460317461 0.311594228426257 0.4065 0.9632 3071586 PK04_108091 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E12 compound treatment 1.082128E7 550000.0 0.47 1.00992E7 506000.0 0.42 9629040.0 -354682.539682539 -0.298245330680874 0.3433 0.491 3188130 PK04_108092 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E13 compound treatment 1.110312E7 831000.0 0.72 1.046684E7 874000.0 0.72 1.080648E7 822757.460317461 0.691840007241883 1.2311 0.9998 3188131 PK04_108093 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E14 compound treatment 1.113584E7 864000.0 0.74 1.015028E7 557000.0 0.46 1.053696E7 553237.460317461 0.465206123326829 0.9649 0.9731 3071587 PK04_108094 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E15 compound treatment 1.04168E7 145000.0 0.12 9265920.0 -327000.0 -0.27 1.037052E7 386797.460317461 0.325250113981245 0.1032 0.2338 3188132 PK04_108095 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E16 compound treatment 1.04374E7 166000.0 0.14 8193760.0 -1400000.0 -1.16 9662360.0 -321362.539682539 -0.270227220662881 -0.7438 -0.6197 3071588 PK04_108096 BrC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E17 mock treatment 1.002064E7 -251000.0 -0.22 9377440.0 -216000.0 -0.18 9743680.0 -240042.539682539 -0.20184688732965 -0.3445 -0.997 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E18 mock treatment 1.024832E7 -23400.0 -0.02 1.010184E7 509000.0 0.42 9452280.0 -531442.539682539 -0.446879218039233 -0.0259 -0.0421 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E19 compound treatment 1.093396E7 662000.0 0.57 1.035844E7 765000.0 0.63 9516520.0 -467202.539682539 -0.392861109169008 0.4689 0.4991 3188133 PK04_108097 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E20 compound treatment 9821320.0 -450000.0 -0.39 9190040.0 -403000.0 -0.33 9128800.0 -854922.539682539 -0.718886967997833 -0.8318 -0.9426 3071589 PK04_108098 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E21 compound treatment 1.027304E7 1360.0 0.0 9650120.0 57100.0 0.05 9714280.0 -269442.539682539 -0.226568749110233 -0.1028 -0.444 3188134 PK04_108099 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E22 compound treatment 9784200.0 -487000.0 -0.42 9077720.0 -515000.0 -0.43 9154000.0 -829722.539682539 -0.697696800757334 -0.8918 -0.9699 3071590 PK04_108100 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E23 compound treatment 9402120.0 -870000.0 -0.75 9986680.0 394000.0 0.33 8982520.0 -1001202.53968254 -0.841890843551017 -0.7296 -0.6221 3188135 PK04_108101 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 E24 compound treatment 7745040.0 -2530000.0 -2.17 7665920.0 -1930000.0 -1.6 7115240.0 -2868482.53968254 -2.41204860088592 -3.571 -0.9866 3071591 PK04_108102 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F01 mock treatment 8521120.0 -1750000.0 -1.51 8574160.0 -1020000.0 -0.85 8749800.0 -1233922.53968254 -1.03758035625772 -1.9569 -0.9711 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F02 mock treatment 8981440.0 -1290000.0 -1.11 9160240.0 -433000.0 -0.36 9484760.0 -498962.539682539 -0.419567446929257 -1.0906 -0.8794 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F03 compound treatment 1.061636E7 345000.0 0.3 8912400.0 -681000.0 -0.56 1.011764E7 133917.460317461 0.11260846748214 -0.0897 -0.1385 3188136 PK04_108103 CC(C)C[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F04 compound treatment 9921600.0 -350000.0 -0.3 9357480.0 -236000.0 -0.2 1.01782E7 194477.460317461 0.16353213923153 -0.1923 -0.4875 3071592 PK04_108104 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F05 compound treatment 1.013232E7 -139000.0 -0.12 9285080.0 -308000.0 -0.26 9718760.0 -264962.539682539 -0.222801608267478 -0.3454 -0.9605 3188137 PK04_108105 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](C)NC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F06 compound treatment 1.102688E7 755000.0 0.65 1.028944E7 696000.0 0.58 1.020284E7 219117.460317461 0.184251413866685 0.8152 0.9171 3071592 PK04_108106 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F07 compound treatment 1.014532E7 -126000.0 -0.11 9822120.0 229000.0 0.19 1.027436E7 290637.460317461 0.244391126606388 0.188 0.5731 3071593 PK04_108107 CC(C)[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F08 compound treatment 9528920.0 -743000.0 -0.64 7983320.0 -1610000.0 -1.34 9358320.0 -625402.539682539 -0.525888270178809 -1.4437 -0.9189 3188138 PK04_108108 Cc1ccc(cc1)S(=O)(=O)N(CCC=C)CC#C[C@H]2Oc3ccccc3S(=O)(=O)N4CCC[C@@H]24 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F09 mock treatment 1.099472E7 723000.0 0.62 1.020416E7 611000.0 0.51 1.005076E7 67037.4603174608 0.0563704363295765 0.6845 0.8507 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F10 mock treatment 1.1013E7 741000.0 0.64 1.061204E7 1020000.0 0.85 1.073196E7 748237.460317461 0.629177655544978 1.2197 0.9901 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F11 compound treatment 1.023684E7 -34800.0 -0.03 1.024032E7 647000.0 0.54 1.00868E7 103077.460317461 0.0866757390021001 0.3428 0.6292 3188139 PK04_108109 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F12 compound treatment 1.132624E7 1050000.0 0.91 1.034372E7 751000.0 0.62 1.072768E7 743957.460317461 0.625578690632703 1.2447 0.9832 3071594 PK04_108110 O=S1(=O)N2CCC[C@H]2[C@H](Oc3ccccc31)C#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F13 compound treatment 1.099484E7 723000.0 0.62 9989600.0 397000.0 0.33 1.0762E7 778277.460317461 0.654437680303097 0.9271 0.9646 3188140 PK04_108111 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](C)NC(=O)[C@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F14 compound treatment 1.0763E7 491000.0 0.42 1.033744E7 744000.0 0.62 1.073404E7 750317.460317461 0.630926685221971 0.9649 0.9857 3414064 PK04_108112 O=S1(=O)N2CCC[C@@H]2[C@@H](Oc3ccccc31)C#C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F15 compound treatment 1.098852E7 717000.0 0.62 1.008384E7 491000.0 0.41 1.09338E7 950077.460317461 0.798900804585548 1.0525 0.967 3071596 PK04_108113 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@H](C)NC(=O)[C@@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F16 compound treatment 1.051916E7 247000.0 0.21 9721000.0 128000.0 0.11 9247320.0 -736402.539682539 -0.619225911595294 -0.1732 -0.2611 3188141 PK04_108114 C=CC(=C)[C@H]1Oc2ccccc2S(=O)(=O)N3CCC[C@@H]13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F17 mock treatment 1.075972E7 488000.0 0.42 1.041988E7 827000.0 0.69 1.041816E7 434437.460317461 0.365309620621618 0.8494 0.9616 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F18 mock treatment 1.040288E7 131000.0 0.11 1.091356E7 1320000.0 1.1 1.037468E7 390957.460317461 0.328748173335232 0.8875 0.7722 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F19 compound treatment 1.057668E7 305000.0 0.26 1.033888E7 746000.0 0.62 1.021984E7 236117.460317461 0.198546367957498 0.6234 0.8895 3188142 PK04_108115 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F20 compound treatment 9201320.0 -1070000.0 -0.92 8640520.0 -952000.0 -0.79 8982160.0 -1001562.53968254 -0.842193560225881 -1.4743 -0.998 3071597 PK04_108116 Cc1ccc(cc1)S(=O)(=O)NC/C=C\C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F21 compound treatment 1.022216E7 -49500.0 -0.04 9590040.0 -2970.0 0.0 9930600.0 -53122.5396825392 -0.0446696627028994 -0.0518 -0.8386 3188143 PK04_108117 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC(=O)[C@H](Cc5ccccc5)NC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F22 compound treatment 9869920.0 -402000.0 -0.35 9723800.0 131000.0 0.11 9602080.0 -381642.539682539 -0.320915446109599 -0.3223 -0.6658 3071598 PK04_108118 Cc1ccc(cc1)S(=O)(=O)NC/C=C/C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F23 compound treatment 9266360.0 -1010000.0 -0.87 9277600.0 -315000.0 -0.26 9224960.0 -758762.539682539 -0.638027980622975 -1.019 -0.921 3188144 PK04_108119 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC(=O)[C@@H](C)NC4=O)[C@@H]5O[C@@]51C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 F24 compound treatment 2846680.0 -7430000.0 -6.39 3077280.0 -6520000.0 -5.41 2702480.0 -7281242.53968254 -6.12264869581392 -10.3451 -0.9976 3188260 PK04_108120 CC(=O)O[C@@H]([C@@H]1CCCN1S(=O)(=O)c2ccccc2[N+](=O)[O-])C(=C)C3=CCN(C3)S(=O)(=O)c4ccc(C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G01 compound treatment 8598120.0 -1670000.0 -1.44 8456200.0 -1140000.0 -0.94 7969720.0 -2014002.53968254 -1.69353375550251 -2.3538 -0.9747 3071599 PK04_108121 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G02 compound treatment 8618000.0 -1650000.0 -1.42 8007400.0 -1590000.0 -1.32 8983120.0 -1000602.53968254 -0.841386315759576 -2.0669 -0.9783 3188261 PK04_108122 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3cccc(C)c3)C(=O)[C@@]42CO4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G03 mock treatment 1.017304E7 -98600.0 -0.08 9351000.0 -242000.0 -0.2 9698520.0 -285202.539682539 -0.239821012432069 -0.3034 -0.9361 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G04 mock treatment 1.021772E7 -54000.0 -0.05 1.006784E7 475000.0 0.39 1.008628E7 102557.460317461 0.0862384815828517 0.2504 0.6169 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G05 compound treatment 1.02994E7 27700.0 0.02 1.002444E7 431000.0 0.36 1.020848E7 224757.460317461 0.188993975106225 0.3295 0.8128 3188262 PK04_108123 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G06 compound treatment 1.012536E7 -146000.0 -0.13 9879240.0 286000.0 0.24 8995480.0 -988242.539682539 -0.830993043255903 -0.4154 -0.4756 3071600 PK04_108124 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(OC)C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G07 compound treatment 1.024256E7 -29100.0 -0.03 9885400.0 292000.0 0.24 1.052516E7 541437.460317461 0.4552837434285 0.3884 0.7521 3189036 PK04_108125 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G08 compound treatment 1.030996E7 38300.0 0.03 9643640.0 50600.0 0.04 9932080.0 -51642.5396825392 -0.0434251608173463 0.0182 0.2645 3071601 PK04_108126 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G09 compound treatment 1.072292E7 451000.0 0.39 1.003428E7 441000.0 0.37 1.04988E7 515077.460317461 0.433118155791215 0.6856 0.9975 3188263 PK04_108127 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G10 compound treatment 1.030644E7 34800.0 0.03 1.00026E7 410000.0 0.34 1.026936E7 285637.460317461 0.240186728344384 0.3521 0.844 3071602 PK04_108128 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G11 compound treatment 1.10256E7 754000.0 0.65 1.016232E7 569000.0 0.47 1.047808E7 494357.460317461 0.415695129393472 0.8873 0.9817 3188264 PK04_108129 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G12 compound treatment 1.112148E7 850000.0 0.73 1.013888E7 546000.0 0.45 1.032496E7 341237.460317461 0.286939637017866 0.8494 0.9367 3071603 PK04_108130 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G13 compound treatment 1.17436E7 1470000.0 1.27 1.034276E7 750000.0 0.62 1.129292E7 1309197.46031746 1.10087750535571 1.7261 0.9644 3188265 PK04_108131 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)Cc7ccc(OC)cc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G14 compound treatment 1.094984E7 678000.0 0.58 9874200.0 281000.0 0.23 1.111996E7 1136237.46031746 0.955438960676475 1.0233 0.8947 3071604 PK04_108132 CCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G15 compound treatment 1.096936E7 698000.0 0.6 1.035204E7 759000.0 0.63 1.076972E7 785997.460317461 0.660929271219631 1.0918 0.9992 3188266 PK04_108133 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)Cc6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G16 compound treatment 1.038616E7 114000.0 0.1 9683280.0 90300.0 0.07 1.022784E7 244117.460317461 0.205273405176704 0.2186 0.9121 3071651 PK04_108134 IC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G17 compound treatment 1.127196E7 1000000.0 0.86 1.126136E7 1670000.0 1.38 1.020012E7 216397.460317461 0.181964221212155 1.4011 0.8543 3188267 PK04_108135 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)Cc5ccc(OC)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G18 compound treatment 1.048796E7 216000.0 0.19 1.001824E7 425000.0 0.35 1.0855E7 871277.460317461 0.732639487976368 0.7341 0.8801 3071652 PK04_108136 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G19 mock treatment 1.047648E7 205000.0 0.18 9907200.0 314000.0 0.26 1.088444E7 900717.460317461 0.757394984943046 0.6895 0.8407 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G20 mock treatment 1.027376E7 2080.0 0.0 1.035904E7 766000.0 0.64 9823800.0 -159922.539682539 -0.134475609579301 0.2903 0.4469 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G21 compound treatment 1.097604E7 704000.0 0.61 1.020608E7 613000.0 0.51 1.02406E7 256877.460317461 0.216003029541338 0.7683 0.9367 3189164 PK04_108137 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccccc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G22 compound treatment 9904160.0 -368000.0 -0.32 8702360.0 -891000.0 -0.74 8894640.0 -1089082.53968254 -0.915787347403996 -1.1379 -0.9339 3071653 PK04_108138 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G23 compound treatment 1.015952E7 -112000.0 -0.1 9325120.0 -268000.0 -0.22 9268840.0 -714882.539682539 -0.60113018147563 -0.5311 -0.8194 3189167 PK04_108139 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)Cc4ccc(OC)cc4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 G24 compound treatment 9000680.0 -1270000.0 -1.09 8564960.0 -1030000.0 -0.85 1.080712E7 823397.460317461 0.692378170219419 -0.7242 -0.4671 3188268 PK04_108140 CCCCO[C@H]1C[C@H]2C(=C[C@]1(CO)C(=O)[C@@]32CO3)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H01 compound treatment 9805520.0 -466000.0 -0.4 8634200.0 -959000.0 -0.8 8645960.0 -1337762.53968254 -1.12489729936302 -1.3403 -0.9341 3188269 PK04_108141 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H02 compound treatment 1.033056E7 58900.0 0.05 9380400.0 -213000.0 -0.18 1.002064E7 36917.4603174608 0.0310431411992655 -0.0547 -0.2936 3071654 PK04_108142 [O-][N+](=O)c1ccccc1S(=O)(=O)N2CCC[C@@H]2[C@H]3OCC=C3C(=C)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H03 mock treatment 1.022008E7 -51600.0 -0.04 9445640.0 -147000.0 -0.12 1.013532E7 151597.460317461 0.127475219736585 -0.0226 -0.1242 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H04 mock treatment 1.111504E7 843000.0 0.73 9775720.0 183000.0 0.15 9947560.0 -36162.5396825392 -0.0304083437981824 0.489 0.6589 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H05 compound treatment 1.045868E7 187000.0 0.16 9582440.0 -10600.0 -0.01 1.000748E7 23757.4603174608 0.0199771649736714 0.0994 0.612 3188270 PK04_108143 CC(C)C[C@@H]1NC(=O)CNC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H06 compound treatment 1.024404E7 -27600.0 -0.02 9745120.0 152000.0 0.13 1.008316E7 99437.4603174608 0.0836149370673613 0.1074 0.7008 3071655 PK04_108144 CN1C(=O)C2CC=C(CC2C1=O)C3=CCO[C@@H]3[C@H]4CCCN4S(=O)(=O)c5ccccc5[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H07 compound treatment 1.033664E7 65000.0 0.06 9832120.0 239000.0 0.2 1.0122E7 138277.460317461 0.116274702766607 0.2139 0.9041 3188271 PK04_108145 CC(C)C[C@H]1NC(=O)CNC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H08 compound treatment 1.022132E7 -50400.0 -0.04 1.12534E7 1660000.0 1.38 1.008664E7 102917.460317461 0.086541198257716 0.8202 0.594 3071656 PK04_108146 CN1C(=C)C2CC3C4C(C5CO[C@H]([C@H]6CCCN6S(=O)(=O)c7ccccc7[N+](=O)[O-])C5=C3CC2C1=O)C(=O)N(C)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H09 compound treatment 1.088156E7 610000.0 0.52 1.018192E7 589000.0 0.49 1.049288E7 509157.460317461 0.428140148249003 0.8323 0.9966 3188272 PK04_108147 CC(C)C[C@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H10 compound treatment 1.078844E7 517000.0 0.44 1.125992E7 1670000.0 1.38 1.085504E7 871317.460317461 0.732673123162464 1.4782 0.9086 3071529 PK04_108148 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H11 compound treatment 1.160044E7 1330000.0 1.14 1.09978E7 1400000.0 1.17 1.053136E7 547637.460317461 0.460497197273384 1.5989 0.9425 3188273 PK04_108149 CC(C)C[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC1=O)[C@@H]6O[C@]6(C)[C@H]4C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H12 compound treatment 1.159528E7 1320000.0 1.14 1.096084E7 1370000.0 1.13 1.089176E7 908037.460317461 0.76355022399862 1.7536 0.9852 3071527 PK04_108150 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H13 compound treatment 1.133896E7 1070000.0 0.92 1.058812E7 995000.0 0.83 1.081444E7 830717.460317461 0.698533409274993 1.4102 0.9939 3071658 PK04_108151 CC(C)C[C@H]1NC(=O)[C@@H](C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H14 compound treatment 1.139644E7 1120000.0 0.97 1.017412E7 581000.0 0.48 1.169408E7 1710357.46031746 1.4382047867128 1.6676 0.9267 3188274 PK04_108152 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H15 compound treatment 1.181284E7 1540000.0 1.33 1.09522E7 1360000.0 1.13 1.034132E7 357597.460317461 0.300696428131143 1.5904 0.9002 3188275 PK04_108153 CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H16 compound treatment 1.107644E7 805000.0 0.69 1.032336E7 730000.0 0.61 1.036308E7 379357.460317461 0.318993969367384 0.9339 0.9588 3071661 PK04_108154 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H17 compound treatment 1.100348E7 732000.0 0.63 9798960.0 206000.0 0.17 1.035956E7 375837.460317461 0.316034072990933 0.6447 0.8892 3188391 PK04_108155 CC(C)C[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H18 compound treatment 1.112996E7 858000.0 0.74 9937080.0 344000.0 0.29 1.017216E7 188437.460317461 0.158453226131029 0.6827 0.8454 3071664 PK04_108156 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)N(Cc6ccccc6)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H19 mock treatment 1.09668E7 695000.0 0.6 1.009388E7 501000.0 0.42 1.019444E7 210717.460317461 0.177188024786518 0.6876 0.9172 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H20 mock treatment 1.12498E7 978000.0 0.84 9394960.0 -198000.0 -0.16 1.044824E7 464517.460317461 0.390603280565833 0.6167 0.6543 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H21 compound treatment 1.069376E7 422000.0 0.36 9832920.0 240000.0 0.2 9946200.0 -37522.5396825392 -0.0315519401254475 0.3064 0.7376 3188392 PK04_108157 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)CNC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H22 compound treatment 1.009332E7 -178000.0 -0.15 9596720.0 3710.0 0.0 9093520.0 -890202.539682539 -0.748553202134532 -0.519 -0.6792 3071666 PK04_108158 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(Cc4ccccc4)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H23 compound treatment 9522120.0 -750000.0 -0.65 9081360.0 -512000.0 -0.42 8821400.0 -1162322.53968254 -0.977373373145828 -1.1818 -0.9488 3188393 PK04_108159 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@@H]6CCCN6C2=O)[C@@H]7O[C@]7(C)[C@H]4C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 H24 compound treatment 8362720.0 -1910000.0 -1.64 8234120.0 -1360000.0 -1.13 1.14554E7 1471677.46031746 1.23750363127779 -0.8849 -0.3773 3071711 PK04_108160 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(Cc4ccccc4)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I01 compound treatment 8796680.0 -1480000.0 -1.27 8801840.0 -791000.0 -0.66 9156040.0 -827682.539682539 -0.695981406266436 -1.5137 -0.9523 3188394 PK04_108161 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5n4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I02 compound treatment 9011240.0 -1260000.0 -1.08 8028800.0 -1560000.0 -1.3 8657960.0 -1325762.53968254 -1.11480674353421 -2.0191 -0.9968 3071714 PK04_108162 OC[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I03 compound treatment 1.02064E7 -65300.0 -0.06 9211120.0 -382000.0 -0.32 9377560.0 -606162.539682539 -0.509709745666619 -0.5096 -0.8455 3188395 PK04_108163 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc5ccccc5c4)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I04 compound treatment 9058000.0 -1210000.0 -1.04 9272280.0 -321000.0 -0.27 9485320.0 -498402.539682539 -0.419096554323912 -0.9986 -0.8635 3071715 PK04_108164 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I05 mock treatment 9997800.0 -274000.0 -0.24 9505680.0 -87300.0 -0.07 1.06036E7 619877.460317461 0.521242343362816 0.123 0.2133 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I06 mock treatment 1.028156E7 9880.0 0.01 9109960.0 -483000.0 -0.4 1.08242E7 840477.460317461 0.706740394682424 0.1816 0.2235 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I07 compound treatment 1.034144E7 69800.0 0.06 9464720.0 -128000.0 -0.11 1.05062E7 522477.460317461 0.439340665218981 0.2269 0.4975 3188396 PK04_108165 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)c4ccc(cc4)c5ccccc5)c6cc(OCCCO)ccc6N1C(=O)c7ccc8ccccc8n7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I08 compound treatment 9358000.0 -914000.0 -0.79 9062920.0 -530000.0 -0.44 9923560.0 -60162.5396825392 -0.0505894554558008 -0.7371 -0.8168 3071717 PK04_108166 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I09 compound treatment 1.050732E7 236000.0 0.2 9686240.0 93200.0 0.08 1.004868E7 64957.4603174608 0.054621406652583 0.1933 0.8636 3188397 PK04_108167 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)C4CCCCC4)c5cc(OCCCO)ccc5N1C(=O)c6ccc7ccccc7n6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I10 compound treatment 1.105468E7 783000.0 0.67 9972560.0 380000.0 0.31 1.095152E7 967797.460317461 0.81380119202609 1.0407 0.9439 3071720 PK04_108168 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I11 compound treatment 1.021272E7 -59000.0 -0.05 1.025508E7 662000.0 0.55 1.067736E7 693637.460317461 0.583265626523896 0.6246 0.778 3188398 PK04_108169 CCOC(=O)C[C@H]1[C@H](OC(=O)c2ccccc2c3ccccc3)[C@@H](NC(=O)CC(C)C)c4cc(OCCCO)ccc4N1C(=O)c5ccc6ccccc6n5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I12 compound treatment 1.07336E7 462000.0 0.4 8903240.0 -690000.0 -0.57 1.083072E7 846997.460317461 0.712222930016077 0.3104 0.3115 3071724 PK04_108170 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@]4(CO4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I13 compound treatment 1.089944E7 628000.0 0.54 9127240.0 -466000.0 -0.39 1.06042E7 620477.460317461 0.521746871154256 0.3901 0.4618 3071725 PK04_108171 COC(=O)[C@H](Cc1ccc(O)cc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I14 compound treatment 1.071452E7 443000.0 0.38 1.125632E7 1660000.0 1.38 1.091192E7 928197.460317461 0.78050235779102 1.4673 0.8999 3071727 PK04_108172 C[C@]12COC[C@@]2(C=C(Br)[C@@H]3C1)C(=O)[C@@]43CO4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I15 compound treatment 9012480.0 -1260000.0 -1.08 6038400.0 -3550000.0 -2.95 8714440.0 -1269282.53968254 -1.06731386076661 -2.9444 -0.8874 3188399 PK04_108173 COC(=O)[C@H](Cc1ccc(O)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I16 compound treatment 1.03234E7 51700.0 0.04 9380680.0 -212000.0 -0.18 1.039128E7 407557.460317461 0.342706775565085 0.1219 0.3142 3071766 PK04_108174 CCCCC[C@H]1OC[C@@]2(C=C(Br)[C@@H]3CC12)C(=O)[C@@]43CO4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I17 compound treatment 1.024976E7 -21900.0 -0.02 8364480.0 -1230000.0 -1.02 9208680.0 -775042.539682539 -0.65171750136406 -0.9756 -0.8063 3188400 PK04_108175 COC(=O)[C@H](Cc1ccc(OCC#C)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I18 compound treatment 1.073444E7 463000.0 0.4 9949440.0 356000.0 0.3 1.053236E7 548637.460317461 0.461338076925785 0.667 0.9846 3071767 PK04_108176 CC1(C)OC[C@@]2(C=C(Br)[C@@H]3C[C@H]12)C(=O)[C@@]43CO4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I19 compound treatment 1.026444E7 -7240.0 -0.01 8010400.0 -1580000.0 -1.31 8633000.0 -1350722.53968254 -1.13579509965813 -1.4173 -0.8164 3188401 PK04_108177 Oc1ccc(C[C@@H]2N(CC#C)[C@@H](/C=C/C3CC3)[C@@H](Cc4ccccc4)OC2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I20 compound treatment 1.133868E7 1070000.0 0.92 9390120.0 -203000.0 -0.17 1.05452E7 561477.460317461 0.472134971662611 0.7056 0.6744 3071770 PK04_108178 BrC1=C[C@]23COCC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I21 mock treatment 1.0691E7 419000.0 0.36 9158840.0 -434000.0 -0.36 9642200.0 -341522.539682539 -0.28717935445528 -0.1654 -0.2826 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I22 mock treatment 9646400.0 -625000.0 -0.54 9120640.0 -472000.0 -0.39 8993360.0 -990362.539682539 -0.832775708118993 -1.0177 -0.9546 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I23 compound treatment 8928520.0 -1340000.0 -1.16 7562280.0 -2030000.0 -1.68 7205440.0 -2778282.53968254 -2.33620125623937 -2.9888 -0.963 3188402 PK04_108179 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccc(OCC#C)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 I24 compound treatment 5982280.0 -4290000.0 -3.69 5133200.0 -4460000.0 -3.7 4308920.0 -5674802.53968254 -4.77182598701123 -7.0224 -0.9923 3071774 PK04_108180 C=CCC1=C[C@H]2[C@H]([C@H]3C=C[C@]2(CC=C)C(=O)[C@@]43CO4)[C@@]5(CO5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J01 compound treatment 8810240.0 -1460000.0 -1.26 8038640.0 -1550000.0 -1.29 9598200.0 -385522.539682539 -0.324178059160914 -1.6578 -0.9058 3188403 PK04_108181 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J02 compound treatment 9375600.0 -896000.0 -0.77 9106280.0 -487000.0 -0.4 8984320.0 -999402.539682539 -0.840377260176695 -1.1636 -0.9617 3071776 PK04_108182 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(Cc5ccccc5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J03 compound treatment 9873360.0 -398000.0 -0.34 9420320.0 -173000.0 -0.14 1.022856E7 244837.460317461 0.205878838526433 -0.1618 -0.3808 3188404 PK04_108183 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@@H](C)NC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J04 compound treatment 9835480.0 -436000.0 -0.38 9164800.0 -428000.0 -0.36 9736000.0 -247722.539682539 -0.208304843060088 -0.5421 -0.9728 3188405 PK04_108184 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J05 mock treatment 1.035164E7 80000.0 0.07 9695360.0 102000.0 0.08 9659000.0 -324722.539682539 -0.273052576294947 -0.0689 -0.2343 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J06 mock treatment 1.00714E7 -200000.0 -0.17 9913680.0 321000.0 0.27 1.033616E7 352437.460317461 0.296357489124755 0.2252 0.5189 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J07 compound treatment 9650840.0 -621000.0 -0.53 9574760.0 -18300.0 -0.02 9830760.0 -152962.539682539 -0.128623087198592 -0.3915 -0.7121 3070928 PK04_108185 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)[C@H](C)NC4=O)[C@@H]6O[C@@]61C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J08 compound treatment 1.07754E7 504000.0 0.43 9717680.0 125000.0 0.1 1.036628E7 382557.460317461 0.321684784255066 0.4957 0.9019 3070929 PK04_108186 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(C)C4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J09 compound treatment 1.124704E7 975000.0 0.84 9581520.0 -11500.0 -0.01 1.0352E7 368277.460317461 0.309677022818783 0.6579 0.7353 3070930 PK04_108187 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J10 compound treatment 1.021996E7 -51700.0 -0.04 9604880.0 11900.0 0.01 1.02628E7 279077.460317461 0.234670557824635 0.1155 0.483 3188406 PK04_108188 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)COc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J11 compound treatment 1.05218E7 250000.0 0.22 1.003936E7 446000.0 0.37 1.091144E7 927717.460317461 0.780098735557867 0.7885 0.886 3188407 PK04_108189 CC(C)C[C@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C1=O)[C@@H]6O[C@]6(C)[C@H]3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J12 compound treatment 1.10544E7 783000.0 0.67 1.020668E7 614000.0 0.51 1.064836E7 664637.460317461 0.558880116604274 1.0055 0.993 3070931 PK04_108190 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J13 compound treatment 1.110332E7 832000.0 0.72 1.029332E7 700000.0 0.58 1.097404E7 990317.460317461 0.832737801798155 1.2294 0.9897 3070932 PK04_108191 OCC(NC(=O)OCC1c2ccccc2-c3ccccc13)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J14 compound treatment 1.079968E7 528000.0 0.45 1.002252E7 430000.0 0.36 1.033E7 346277.460317461 0.291177670465966 0.6362 0.9837 3070933 PK04_108192 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J15 compound treatment 1.02972E7 25500.0 0.02 9048880.0 -544000.0 -0.45 9723360.0 -260362.539682539 -0.218933561866434 -0.3743 -0.7454 3188522 PK04_108193 COc1ccc(CN([C@H](COC(=O)OC(C)(C)C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J16 compound treatment 1.070704E7 435000.0 0.37 9690080.0 97100.0 0.08 1.015056E7 166837.460317461 0.140290225639173 0.3438 0.8424 3188523 PK04_108194 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J17 compound treatment 1.128084E7 1010000.0 0.87 1.019544E7 602000.0 0.5 1.030336E7 319637.460317461 0.26877663652601 0.9452 0.911 3070934 PK04_108195 CC(=O)OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J18 compound treatment 1.14582E7 1190000.0 1.02 9481600.0 -111000.0 -0.09 9966280.0 -17442.5396825392 -0.0146670767052401 0.5277 0.5146 3188524 PK04_108196 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J19 compound treatment 1.092568E7 654000.0 0.56 9492440.0 -101000.0 -0.08 1.001712E7 33397.4603174608 0.0280832448228148 0.293 0.5143 3070935 PK04_108197 O=C(CCCCCCC(=O)Nc1ccccc1)N/N=C/c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J20 compound treatment 1.016964E7 -102000.0 -0.09 9397720.0 -195000.0 -0.16 1.00638E7 80077.4603174608 0.0673355069968825 -0.1054 -0.537 3188525 PK04_108198 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J21 mock treatment 1.001492E7 -257000.0 -0.22 9035280.0 -558000.0 -0.46 9998360.0 14637.4603174608 0.0123083425437764 -0.3876 -0.7557 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J22 mock treatment 1.027624E7 4560.0 0.0 9707600.0 115000.0 0.1 9798720.0 -185002.539682539 -0.155564871261512 -0.0327 -0.1791 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J23 compound treatment 9557920.0 -714000.0 -0.61 8922680.0 -670000.0 -0.56 8874760.0 -1108962.53968254 -0.932504034893723 -1.2141 -0.9733 3070936 PK04_108199 C/C(=N\O)/C(=O)NCCCCCNC(=O)OCc1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 J24 compound treatment 7507240.0 -2760000.0 -2.38 7327000.0 -2270000.0 -1.88 7358480.0 -2625242.53968254 -2.20751303423596 -3.7334 -0.9954 3188526 PK04_108200 OB1C[C@H]2C(=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O)[C@@H](CCc6ccccc6)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K01 compound treatment 8711760.0 -1560000.0 -1.34 7476640.0 -2120000.0 -1.76 8102840.0 -1880882.53968254 -1.58159585617492 -2.7019 -0.9942 3070937 PK04_108201 COC(=O)[C@H](Cc1ccc(O)cc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K02 compound treatment 8158160.0 -2110000.0 -1.82 8075120.0 -1520000.0 -1.26 7887720.0 -2096002.53968254 -1.76248588699937 -2.7948 -0.9881 3188527 PK04_108202 CC1=C[C@]2(CO)C(=O)[C@]3(CO3)[C@H]1[C@@H]4[C@@]5(CO5)C(=O)C(=C[C@@]42C)CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K03 compound treatment 9805360.0 -466000.0 -0.4 9382120.0 -211000.0 -0.17 9529720.0 -454002.539682539 -0.381761497757318 -0.5531 -0.9522 3188528 PK04_108203 Oc1ccc(C[C@@H]2N3CC4=CCCC=C[C@@H]4[C@H]3[C@@H](Cc5ccccc5)OC2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K04 compound treatment 1.007904E7 -193000.0 -0.17 8805400.0 -788000.0 -0.65 8797360.0 -1186362.53968254 -0.997588119989543 -1.0489 -0.8712 3070938 PK04_108204 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K05 compound treatment 9575760.0 -696000.0 -0.6 9090760.0 -502000.0 -0.42 9974240.0 -9482.53968253918 -0.00797367467213001 -0.591 -0.8099 3188529 PK04_108205 COC(=O)[C@H](Cc1ccccc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K06 compound treatment 9743400.0 -528000.0 -0.45 9280480.0 -313000.0 -0.26 9641480.0 -342242.539682539 -0.287784787805009 -0.5783 -0.9683 3070939 PK04_108206 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)c4ccccc4)C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K07 mock treatment 1.034732E7 75600.0 0.07 9915160.0 322000.0 0.27 1.028616E7 302437.460317461 0.254313506504717 0.3387 0.9042 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K08 mock treatment 9803120.0 -469000.0 -0.4 9053760.0 -539000.0 -0.45 1.059756E7 613837.460317461 0.516163430262315 -0.1931 -0.2434 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K09 compound treatment 8587760.0 -1680000.0 -1.45 7866240.0 -1730000.0 -1.43 9130920.0 -852802.539682539 -0.717104303134743 -2.0778 -0.9618 3188530 PK04_108207 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K10 compound treatment 1.003896E7 -233000.0 -0.2 9416320.0 -177000.0 -0.15 9561800.0 -421922.539682539 -0.354786078508302 -0.4051 -0.9356 3188531 PK04_108208 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Oc4ccccc4)cc3)C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K11 compound treatment 6994120.0 -3280000.0 -2.82 7797040.0 -1800000.0 -1.49 8120040.0 -1863682.53968254 -1.56713272615363 -3.3936 -0.9548 3070940 PK04_108209 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K12 compound treatment 1.01928E7 -78900.0 -0.07 9833960.0 241000.0 0.2 1.020052E7 216797.460317461 0.182300573073115 0.1815 0.6506 3188532 PK04_108210 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)C(F)(F)F)C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K13 compound treatment 9701160.0 -571000.0 -0.49 9059880.0 -533000.0 -0.44 9128840.0 -854882.539682539 -0.718853332811737 -0.9539 -0.9769 3188533 PK04_108211 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K14 compound treatment 1.052168E7 250000.0 0.22 1.014064E7 548000.0 0.45 1.107276E7 1089037.46031746 0.915749441083159 0.9152 0.8761 3070941 PK04_108212 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4[nH]ccc4c3)C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K15 mock treatment 1.066128E7 390000.0 0.34 1.01686E7 576000.0 0.48 1.039844E7 414717.460317461 0.348727473876275 0.6706 0.9866 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K16 mock treatment 1.0266E7 -5680.0 0.0 1.017312E7 580000.0 0.48 1.032316E7 339437.460317461 0.285426053643545 0.4398 0.786 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K17 compound treatment 1.031136E7 39700.0 0.03 1.001712E7 424000.0 0.35 9850240.0 -133482.539682539 -0.112242751569825 0.158 0.4261 3188534 PK04_108213 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K18 compound treatment 1.030268E7 31000.0 0.03 9456880.0 -136000.0 -0.11 9314320.0 -669402.539682539 -0.562886974884443 -0.3748 -0.6521 3070942 PK04_108214 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3cccc4[nH]ccc34)C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K19 compound treatment 1.080848E7 537000.0 0.46 1.015652E7 564000.0 0.47 1.03582E7 374477.460317461 0.314890476663668 0.7184 0.9858 3188535 PK04_108215 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K20 compound treatment 1.023528E7 -36400.0 -0.03 9784320.0 191000.0 0.16 9481200.0 -502522.539682539 -0.422560978491803 -0.1704 -0.3767 3070943 PK04_108216 CC(C)Oc1ccc(cc1)C(=O)N2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K21 compound treatment 9130920.0 -1140000.0 -0.98 8494880.0 -1100000.0 -0.91 8350800.0 -1632922.53968254 -1.37309133756563 -1.8855 -0.983 3188536 PK04_108217 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K22 compound treatment 1.026884E7 -2840.0 0.0 9054240.0 -539000.0 -0.45 8963160.0 -1020562.53968254 -0.858170273621496 -0.7549 -0.7802 3188537 PK04_108218 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Br)cc3)C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K23 mock treatment 9735760.0 -536000.0 -0.46 8914880.0 -678000.0 -0.56 9210000.0 -773722.539682539 -0.650607540222891 -0.9667 -0.9905 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 K24 mock treatment 8077720.0 -2190000.0 -1.89 8207800.0 -1390000.0 -1.15 7879560.0 -2104162.53968254 -1.76934746496296 -2.7751 -0.9802 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L01 compound treatment 8943800.0 -1330000.0 -1.14 8465120.0 -1130000.0 -0.94 8828160.0 -1155562.53968254 -0.971689026695599 -1.761 -0.9961 3070944 PK04_108219 O/N=C(\Cc1ccccc1)/C(=O)NCCCCCNC(=O)OCc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L02 compound treatment 8878920.0 -1390000.0 -1.2 8689120.0 -904000.0 -0.75 9417160.0 -566562.539682539 -0.476410911431548 -1.4 -0.9384 3188538 PK04_108220 CCCC[C@H]1OB(O)C[C@H]2C1=C(C)Cn3n2c(=O)n(c4ccccc4)c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L03 compound treatment 9980680.0 -291000.0 -0.25 9248880.0 -344000.0 -0.29 9830240.0 -153482.539682539 -0.12906034461784 -0.3839 -0.9572 3188539 PK04_108221 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L04 compound treatment 1.050484E7 233000.0 0.2 9892880.0 300000.0 0.25 1.006632E7 82597.4603174608 0.0694545237209324 0.2996 0.9159 3215882 PK04_108222 CCCC[C@H]1OB(O)C[C@H]2C1=C(COC)Cn3n2c(=O)n(c4ccccc4)c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L05 compound treatment 1.085448E7 583000.0 0.5 1.014844E7 555000.0 0.46 9566120.0 -417602.539682539 -0.35115347840993 0.3529 0.4605 3188540 PK04_108223 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L06 compound treatment 1.111544E7 844000.0 0.73 9859920.0 267000.0 0.22 1.047148E7 487757.460317461 0.410145323687626 0.7839 0.9085 3215880 PK04_108224 CCCC[C@H]1OB(O)C[C@H]2C1=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L07 mock treatment 1.075364E7 482000.0 0.41 9896320.0 303000.0 0.25 1.069672E7 712997.460317461 0.599545056594375 0.7309 0.9477 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L08 mock treatment 1.041236E7 141000.0 0.12 1.015736E7 564000.0 0.47 1.022708E7 243357.460317461 0.204634336640879 0.4583 0.8729 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L09 compound treatment 1.096956E7 698000.0 0.6 1.040292E7 810000.0 0.67 1.108184E7 1098117.46031746 0.923384628326957 1.2678 0.9826 3188541 PK04_108225 C[C@@H]1ON([C@@H]([C@H]1C(=O)O)c2ccccc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L10 compound treatment 1.006604E7 -206000.0 -0.18 9376960.0 -216000.0 -0.18 9500440.0 -483282.539682539 -0.406382453979613 -0.4403 -0.9209 3188542 PK04_108226 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L11 compound treatment 1.012436E7 -147000.0 -0.13 9689240.0 96200.0 0.08 9926880.0 -56842.5396825392 -0.0477977350098302 -0.0547 -0.3479 3070947 PK04_108227 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L12 compound treatment 1.020148E7 -70200.0 -0.06 8694920.0 -898000.0 -0.75 8947440.0 -1036282.53968254 -0.871388901757236 -0.9681 -0.8433 3188543 PK04_108228 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L13 compound treatment 1.092572E7 654000.0 0.56 9906040.0 313000.0 0.26 1.014544E7 161717.460317461 0.135984921818881 0.5534 0.872 3188544 PK04_108229 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L14 compound treatment 1.02358E7 -35900.0 -0.03 9661680.0 68700.0 0.06 1.024028E7 256557.460317461 0.21573394805257 0.1396 0.6198 3070948 PK04_108230 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)C=CC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L15 mock treatment 1.116428E7 893000.0 0.77 1.015836E7 565000.0 0.47 1.076296E7 779237.460317461 0.655244924769402 1.0926 0.9814 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L16 mock treatment 1.03788E7 107000.0 0.09 1.023928E7 646000.0 0.54 1.047272E7 488997.460317461 0.411188014456603 0.6002 0.8801 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L17 compound treatment 1.027364E7 1960.0 0.0 1.034988E7 757000.0 0.63 9677120.0 -306602.539682539 -0.257815836993445 0.2146 0.3162 3188657 PK04_108231 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5cccc(c5)C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L18 compound treatment 1.021516E7 -56500.0 -0.05 1.033952E7 747000.0 0.62 1.02654E7 281677.460317461 0.236856844920877 0.4662 0.7013 3070949 PK04_108232 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)C=CC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L19 compound treatment 9920200.0 -351000.0 -0.3 9433760.0 -159000.0 -0.13 9495560.0 -488162.539682539 -0.410485946683328 -0.4879 -0.9263 3188658 PK04_108233 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L20 compound treatment 9569200.0 -702000.0 -0.6 9615560.0 22500.0 0.02 1.006636E7 82637.4603174608 0.0694881589070285 -0.2981 -0.4897 3070950 PK04_108234 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)C=CC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L21 compound treatment 1.018748E7 -84200.0 -0.07 9735320.0 142000.0 0.12 1.026792E7 284197.460317461 0.238975861644927 0.1643 0.5948 3188659 PK04_108235 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4cccc(NC(=O)OCC5c6ccccc6-c7ccccc57)c4)c8ccc(I)cc8 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L22 compound treatment 1.017692E7 -94800.0 -0.08 9102920.0 -490000.0 -0.41 9945040.0 -38682.5396825392 -0.0325273605222324 -0.3006 -0.7227 3070951 PK04_108236 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)C=CC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L23 mock treatment 9720120.0 -552000.0 -0.47 9148880.0 -444000.0 -0.37 9580200.0 -403522.539682539 -0.339313892904128 -0.6827 -0.9893 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 L24 mock treatment 8458200.0 -1810000.0 -1.56 7746920.0 -1850000.0 -1.53 8537480.0 -1446242.53968254 -1.21611592405545 -2.4874 -0.9942 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M01 compound treatment 8018480.0 -2250000.0 -1.94 7071960.0 -2520000.0 -2.09 8039640.0 -1944082.53968254 -1.63473945020665 -3.2709 -0.995 3188660 PK04_108237 COC(=O)[C@H](Cc1ccccc1)N[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M02 compound treatment 8630720.0 -1640000.0 -1.41 8397200.0 -1200000.0 -0.99 8888320.0 -1095402.53968254 -0.921101706807169 -1.9199 -0.9814 3070952 PK04_108238 CC(C)Cc1ccc(CN2CC[C@@H](N)C2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M03 compound treatment 7781520.0 -2490000.0 -2.14 7664360.0 -1930000.0 -1.6 7820240.0 -2163482.53968254 -1.81922844594338 -3.2114 -0.9928 3188661 PK04_108239 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M04 compound treatment 7140480.0 -3130000.0 -2.69 8193120.0 -1400000.0 -1.16 7931960.0 -2051762.53968254 -1.72528537117716 -3.2224 -0.9467 3070953 PK04_108240 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3ccccc3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M05 compound treatment 8664880.0 -1610000.0 -1.38 8314240.0 -1280000.0 -1.06 8486280.0 -1497442.53968254 -1.25916896225837 -2.1379 -0.9943 3188662 PK04_108241 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@@H]2[C@@H](O)Cc3ccccc3)/C=C/C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M06 compound treatment 9973200.0 -298000.0 -0.26 8891920.0 -701000.0 -0.58 9716280.0 -267442.539682539 -0.224886989805431 -0.6139 -0.9103 3070954 PK04_108242 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)c3ccccc3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M07 compound treatment 9796720.0 -475000.0 -0.41 9245680.0 -347000.0 -0.29 9253000.0 -730722.539682539 -0.614449715169658 -0.7571 -0.9556 3188663 PK04_108243 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M08 compound treatment 2269080.0 -8000000.0 -6.89 2223880.0 -7370000.0 -6.11 3012000.0 -6971722.53968254 -5.86237962580283 -10.8905 -0.9976 3188664 PK04_108244 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)Nc3ccccc3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M09 mock treatment 1.039476E7 123000.0 0.11 9073160.0 -520000.0 -0.43 9711200.0 -272522.539682539 -0.229158658439627 -0.3201 -0.6406 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M10 mock treatment 1.014324E7 -128000.0 -0.11 9816120.0 223000.0 0.19 9751000.0 -232722.539682539 -0.195691648274077 -0.0699 -0.2402 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M11 compound treatment 9465800.0 -806000.0 -0.69 9018760.0 -574000.0 -0.48 9744600.0 -239122.539682539 -0.201073278049442 -0.7916 -0.915 3070955 PK04_108245 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M12 compound treatment 1.076828E7 497000.0 0.43 9208560.0 -384000.0 -0.32 9271520.0 -712202.539682539 -0.598876624007196 -0.2831 -0.3531 3188665 PK04_108246 CC(C)Oc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M13 mock treatment 1.02666E7 -5080.0 0.0 1.028656E7 694000.0 0.58 1.026416E7 280437.460317461 0.2358141541519 0.4658 0.7491 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M14 mock treatment 1.06988E7 427000.0 0.37 1.009764E7 505000.0 0.42 1.068132E7 697597.460317461 0.586595509947403 0.7926 0.9797 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M15 compound treatment 9371320.0 -900000.0 -0.77 8173480.0 -1420000.0 -1.18 9266200.0 -717522.539682539 -0.603350103757968 -1.4756 -0.9623 3188666 PK04_108247 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M16 compound treatment 9976840.0 -295000.0 -0.25 9497680.0 -95300.0 -0.08 8342240.0 -1641482.53968254 -1.38028926739018 -0.9891 -0.7036 3070994 PK04_108248 CC(C)Oc1ccc(CN2CC[C@@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M17 compound treatment 9184760.0 -1090000.0 -0.94 8249280.0 -1340000.0 -1.11 8538600.0 -1445122.53968254 -1.21517413884476 -1.8852 -0.9944 3188667 PK04_108249 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4ccccc4Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M18 compound treatment 9543120.0 -729000.0 -0.63 9521400.0 -71600.0 -0.06 1.01582E7 174477.460317461 0.146714546183515 -0.3116 -0.4818 3070995 PK04_108250 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4OCOc4c3)C2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M19 compound treatment 9102520.0 -1170000.0 -1.01 8731240.0 -862000.0 -0.71 8817320.0 -1166402.53968254 -0.980804162127623 -1.56 -0.9895 3188668 PK04_108251 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/c2ccccc2)[C@@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M20 compound treatment 1.00928E7 -179000.0 -0.15 9428160.0 -165000.0 -0.14 1.027968E7 295957.460317461 0.24886460635716 -0.0242 -0.0748 2133134 PK04_108252 CCCCC(=O)N(CCN1CCOCC1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M21 compound treatment 9282400.0 -989000.0 -0.85 7944920.0 -1650000.0 -1.37 8653880.0 -1329842.53968254 -1.118237532516 -1.9265 -0.9825 3070996 PK04_108253 O[C@@H](Cc1ccccc1)[C@@H](/C=C/c2ccccc2)N(CC#C)Cc3ccccc3Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M22 compound treatment 1.004044E7 -231000.0 -0.2 9210520.0 -382000.0 -0.32 8989960.0 -993762.539682539 -0.835634698937155 -0.7806 -0.8524 2133147 PK04_108254 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCCO4)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M23 compound treatment 9145360.0 -1130000.0 -0.97 8526720.0 -1070000.0 -0.88 8527680.0 -1456042.53968254 -1.22435654464898 -1.7772 -0.9902 3070997 PK04_108255 CCCC/C=C/[C@H]([C@@H](O)Cc1ccccc1)N(CC#Cc2ccccc2)Cc3ccccc3Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 M24 compound treatment 8799240.0 -1470000.0 -1.27 8495480.0 -1100000.0 -0.91 9066240.0 -917482.539682539 -0.771492399052025 -1.7027 -0.9782 3188671 PK04_108256 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCCc3c[nH]c4ccccc34)[C@@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N01 compound treatment 8299920.0 -1970000.0 -1.7 7623720.0 -1970000.0 -1.63 8602760.0 -1380962.53968254 -1.16122330034673 -2.5934 -0.9875 3188672 PK04_108257 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(OC(=O)OC(C)(C)C)cc4)c5ccc(I)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N02 compound treatment 9850520.0 -421000.0 -0.36 9845560.0 253000.0 0.21 8761520.0 -1222202.53968254 -1.02772524673159 -0.6817 -0.6143 3070998 PK04_108258 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N03 compound treatment 9395040.0 -877000.0 -0.75 9636360.0 43300.0 0.04 9285680.0 -698042.539682539 -0.586969768129201 -0.7537 -0.7879 3188673 PK04_108259 COC(=O)CCCCCCC(=O)Nc1ccc(NC(=O)CCCC[P+](c2ccccc2)(c3ccccc3)c4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N04 compound treatment 9952800.0 -319000.0 -0.27 9276000.0 -317000.0 -0.26 1.027936E7 295637.460317461 0.248595524868391 -0.1668 -0.3672 3070999 PK04_108260 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N05 compound treatment 1.010232E7 -169000.0 -0.15 9396640.0 -196000.0 -0.16 9166720.0 -817002.539682539 -0.687000811578796 -0.5748 -0.7974 3188674 PK04_108261 CC(C)[C@H]1COC(=O)N1C(=O)[C@@H]2[C@@H](C)ON([C@@H]2c3ccccc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N06 compound treatment 9251440.0 -1020000.0 -0.88 8607080.0 -986000.0 -0.82 8887320.0 -1096402.53968254 -0.92194258645957 -1.5114 -0.9988 3071000 PK04_108262 OC[C@@H]1[C@H]2[C@@H](CC(=C1[C@H](O)CCc3ccccc3)COc4ccccc4)C(=O)N(Cc5ccccc5)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N07 compound treatment 9950440.0 -321000.0 -0.28 9613120.0 20100.0 0.02 9475720.0 -508002.539682539 -0.427168998986959 -0.3966 -0.779 3188675 PK04_108263 CC(C)[C@@H](CO)NC(=O)[C@@H]1[C@@H](C)ON([C@@H]1c2ccccc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N08 compound treatment 1.005488E7 -217000.0 -0.19 9363800.0 -229000.0 -0.19 9640280.0 -343442.539682539 -0.28879384338789 -0.3842 -0.978 3188676 PK04_108264 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N09 mock treatment 9852000.0 -420000.0 -0.36 9499840.0 -93200.0 -0.08 1.016076E7 177037.460317461 0.148867198093661 -0.1672 -0.4199 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N10 mock treatment 1.063676E7 365000.0 0.31 9567440.0 -25600.0 -0.02 9443760.0 -539962.539682539 -0.454043512677688 -0.093 -0.1683 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N11 compound treatment 1.043488E7 163000.0 0.14 9514560.0 -78500.0 -0.07 9745440.0 -238282.539682539 -0.200366939141425 -0.0722 -0.285 3071001 PK04_108265 COC(=O)[C@@H]1N[C@H]2[C@@H](COc3ccccc23)[C@@H]1C(=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N12 compound treatment 1.089684E7 625000.0 0.54 1.015552E7 563000.0 0.47 9752960.0 -230762.539682539 -0.194043524155371 0.468 0.634 3188677 PK04_108266 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N13 mock treatment 1.026996E7 -1720.0 0.0 9908200.0 315000.0 0.26 1.058036E7 596637.460317461 0.501700300241022 0.4398 0.7773 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N14 mock treatment 1.03124E7 40700.0 0.04 1.048948E7 896000.0 0.74 9984920.0 1197.46031746082 0.00100692001551016 0.4502 0.6047 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N15 compound treatment 1.047892E7 207000.0 0.18 9269640.0 -323000.0 -0.27 9722520.0 -261202.539682539 -0.219639900774451 -0.1787 -0.4584 3071002 PK04_108267 OCC1CC(=NO1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N16 compound treatment 9752840.0 -519000.0 -0.45 9771720.0 179000.0 0.15 9658240.0 -325482.539682539 -0.273691644830772 -0.3302 -0.6067 3188788 PK04_108268 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(Cc4ccccc4)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N17 compound treatment 1.063324E7 362000.0 0.31 9876000.0 283000.0 0.23 9267960.0 -715762.539682539 -0.601870155569742 -0.0323 -0.045 3071004 PK04_108269 O[C@H](C=C)[C@H]1CC(=NO1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N18 compound treatment 9336840.0 -935000.0 -0.8 9306280.0 -287000.0 -0.24 9330240.0 -653482.539682539 -0.549500170818223 -0.9191 -0.9164 3071005 PK04_108270 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N19 compound treatment 9837920.0 -434000.0 -0.37 9469160.0 -124000.0 -0.1 9625640.0 -358082.539682539 -0.301104321499037 -0.4487 -0.9148 3414065 PK04_108271 O[C@@H]([C@H]1CC(=NO1)c2ccccc2)[C@@H]3CC(=NO3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N20 compound treatment 9445360.0 -826000.0 -0.71 8684520.0 -908000.0 -0.75 9119480.0 -864242.539682539 -0.726723966358208 -1.2653 -0.9997 3188790 PK04_108272 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N21 compound treatment 9770640.0 -501000.0 -0.43 9191640.0 -401000.0 -0.33 9535000.0 -448722.539682539 -0.377321653192642 -0.659 -0.9945 3071008 PK04_108273 CC[C@H](C)C(=O)O[C@H]1CC[C@@]2(C)C(CCC3=C2CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CCCC(C)C)C1(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N22 compound treatment 9480080.0 -792000.0 -0.68 8597040.0 -996000.0 -0.83 8793160.0 -1190562.53968254 -1.00111981452963 -1.4484 -0.988 3188791 PK04_108274 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)COc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N23 compound treatment 9326040.0 -946000.0 -0.81 8760840.0 -832000.0 -0.69 9119400.0 -864322.539682539 -0.7267912367304 -1.2881 -0.9976 3188792 PK04_108275 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)CCl)C(C)(C)C4CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 N24 compound treatment 8175640.0 -2100000.0 -1.8 7287760.0 -2310000.0 -1.91 8075880.0 -1907842.53968254 -1.60426597160365 -3.0718 -0.9974 3188793 PK04_108276 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O01 compound treatment 7421800.0 -2850000.0 -2.45 6850560.0 -2740000.0 -2.28 7094080.0 -2889642.53968254 -2.42984161433072 -4.1325 -0.9995 3071055 PK04_108277 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O02 compound treatment 8922960.0 -1350000.0 -1.16 8661040.0 -932000.0 -0.77 8453840.0 -1529882.53968254 -1.28644709818225 -1.8593 -0.9799 2129060 PK04_108278 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCC3CCCCC3)[C@@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O03 compound treatment 7649320.0 -2620000.0 -2.26 8401280.0 -1190000.0 -0.99 7889680.0 -2094042.53968254 -1.76083776288067 -2.8904 -0.9544 3188794 PK04_108279 O[C@@H](Cc1ccccc1)[C@H](NCc2cccc(Cl)c2)/C=C/C3CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O04 compound treatment 9535040.0 -737000.0 -0.63 9098840.0 -494000.0 -0.41 9230480.0 -753242.539682539 -0.633386324941723 -0.9684 -0.9827 2129057 PK04_108280 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC[C@@H]3CCCO3)[C@@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O05 compound treatment 8018480.0 -2250000.0 -1.94 8116720.0 -1480000.0 -1.22 8340200.0 -1643522.53968254 -1.38200466188108 -2.6246 -0.9801 3188796 PK04_108281 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4cccc(Cl)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O06 compound treatment 9642920.0 -629000.0 -0.54 9286600.0 -306000.0 -0.25 9707880.0 -275842.539682539 -0.231950378885598 -0.5931 -0.9249 2129061 PK04_108282 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC3CCCCCC3)[C@@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O07 compound treatment 8644280.0 -1630000.0 -1.4 8401920.0 -1190000.0 -0.99 9797280.0 -186442.539682539 -0.156775737960969 -1.4696 -0.8538 3071060 PK04_108283 O[C@@H](Cc1ccccc1)[C@H](NCc2ccccc2Br)/C=C/c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O08 compound treatment 9983400.0 -288000.0 -0.25 9336800.0 -256000.0 -0.21 1.047356E7 489837.460317461 0.41189435336462 -0.0282 -0.0535 2129067 PK04_108284 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccccc3F)[C@@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O09 compound treatment 9440520.0 -831000.0 -0.72 8280120.0 -1310000.0 -1.09 1.013852E7 154797.460317461 0.130166034624268 -0.9667 -0.7382 3188797 PK04_108285 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC=C3CN2Cc4cccc(Cl)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O10 compound treatment 1.123916E7 967000.0 0.83 1.047324E7 880000.0 0.73 1.08008E7 817077.460317461 0.687063810816246 1.299 0.9967 2129068 PK04_108286 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccc(F)cc3)[C@@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O11 mock treatment 1.001672E7 -255000.0 -0.22 9512360.0 -80700.0 -0.07 1.044288E7 459157.460317461 0.386096165628965 0.0576 0.1282 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O12 mock treatment 1.018396E7 -87700.0 -0.08 8880920.0 -712000.0 -0.59 9880040.0 -103682.539682539 -0.0871845379282821 -0.435 -0.7227 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O13 compound treatment 9582960.0 -689000.0 -0.59 8658200.0 -935000.0 -0.78 9162080.0 -821642.539682539 -0.690902493165935 -1.1888 -0.9941 3188798 PK04_108287 COC1(C)CN(Cc2ccccc2Br)[C@H](/C=C/c3ccccc3)[C@H](Cc4ccccc4)O1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O14 compound treatment 1.105956E7 788000.0 0.68 9538840.0 -54200.0 -0.04 9758520.0 -225202.539682539 -0.189368233288023 0.2562 0.3632 3071064 PK04_108288 CCCC(=O)N(CCc1c[nH]c2ccccc12)[C@@H]3CC(=C[C@H](Oc4c(I)cc(CO)cc4OC)[C@H]3O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O15 compound treatment 9823080.0 -449000.0 -0.39 9653440.0 60400.0 0.05 8732000.0 -1251722.53968254 -1.05254801407046 -0.8017 -0.7143 3188799 PK04_108289 CN1C(=O)C2C3[C@H]([C@@H](O)Cc4ccccc4)N(Cc5cccc(Cl)c5)CC3=CC(C6CC6)C2C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O16 compound treatment 9779760.0 -492000.0 -0.42 9325240.0 -268000.0 -0.22 9751600.0 -232122.539682539 -0.195187120482636 -0.4854 -0.9399 2133032 PK04_108290 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4ccc(cc4)C(F)(F)F)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O17 compound treatment 8998880.0 -1270000.0 -1.1 8131760.0 -1460000.0 -1.21 8159760.0 -1823962.53968254 -1.53373298636027 -2.2178 -0.9897 3071066 PK04_108291 O[C@@H](Cc1ccccc1)[C@H](N(CC#C)CC2=CCCCC2)c3ccccc3Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O18 compound treatment 9215440.0 -1060000.0 -0.91 8664480.0 -929000.0 -0.77 9217040.0 -766682.539682539 -0.644687747469989 -1.3418 -0.9904 2133035 PK04_108292 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O19 compound treatment 9575760.0 -696000.0 -0.6 8449360.0 -1140000.0 -0.95 9424120.0 -559602.539682539 -0.470558389050839 -1.1652 -0.9577 3071068 PK04_108293 O=C(Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4ccccc4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O20 compound treatment 9420280.0 -851000.0 -0.73 8393800.0 -1200000.0 -0.99 9117600.0 -866122.539682539 -0.728304820104722 -1.4179 -0.9886 2133267 PK04_108294 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(Cc3ccc(F)cc3)C(=O)C4CCCO4)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O21 compound treatment 9696360.0 -575000.0 -0.5 8566440.0 -1030000.0 -0.85 8488400.0 -1495322.53968254 -1.25738629739528 -1.5035 -0.9413 3071112 PK04_108295 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4cccc(Cl)c4)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O22 compound treatment 9134640.0 -1140000.0 -0.98 8619560.0 -973000.0 -0.81 8829640.0 -1154082.53968254 -0.970444524810046 -1.5915 -0.9963 2133153 PK04_108296 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCOC4)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O23 compound treatment 8092280.0 -2180000.0 -1.88 8342760.0 -1250000.0 -1.04 8291880.0 -1691842.53968254 -1.42263596668508 -2.5031 -0.973 3188804 PK04_108297 Clc1cccc(CN2CC3=CCCC=CC3[C@@H]2[C@H](Cc4ccccc4)OC(=O)C=C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 O24 compound treatment 7103880.0 -3170000.0 -2.73 8447560.0 -1150000.0 -0.95 6822400.0 -3161322.53968254 -2.65829179829496 -3.6574 -0.9319 2132929 PK04_108298 CC/C=C/C(=O)N(C[C@@H]1CCCO1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P01 compound treatment 6894080.0 -3380000.0 -2.91 6153800.0 -3440000.0 -2.85 6565520.0 -3418202.53968254 -2.87429696340367 -4.985 -1.0 3188805 PK04_108299 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)C(C)(C)C)C(C)(C)C4CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P02 compound treatment 8329920.0 -1940000.0 -1.67 7499200.0 -2090000.0 -1.74 7637880.0 -2345842.53968254 -1.97257125935518 -3.1065 -0.9974 3071118 PK04_108300 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P03 compound treatment 8489320.0 -1780000.0 -1.53 8077280.0 -1520000.0 -1.26 8686080.0 -1297642.53968254 -1.0911612077087 -2.2416 -0.9902 3188806 PK04_108301 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccccc5)C(C)(C)C4CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P04 compound treatment 8609640.0 -1660000.0 -1.43 8185840.0 -1410000.0 -1.17 8524840.0 -1458882.53968254 -1.2267446428618 -2.2081 -0.9961 3071120 PK04_108302 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(C)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P05 compound treatment 8619680.0 -1650000.0 -1.42 8640560.0 -952000.0 -0.79 9200920.0 -782802.539682539 -0.65824272746669 -1.6571 -0.9444 3188807 PK04_108303 COc1ccc(cc1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P06 compound treatment 9118880.0 -1150000.0 -0.99 9218400.0 -375000.0 -0.31 9035080.0 -948642.539682539 -0.797694209020833 -1.2128 -0.9255 3188808 PK04_108304 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P07 compound treatment 8347840.0 -1920000.0 -1.66 7980120.0 -1610000.0 -1.34 9342240.0 -641482.539682539 -0.539409614989414 -2.0399 -0.9289 3071124 PK04_108305 COc1cccc(c1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P08 compound treatment 9326600.0 -945000.0 -0.81 8799000.0 -794000.0 -0.66 9051640.0 -932082.539682539 -0.783769241977076 -1.3024 -0.996 3188923 PK04_108306 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P09 compound treatment 8830640.0 -1440000.0 -1.24 7835080.0 -1760000.0 -1.46 8069560.0 -1914162.53968254 -1.60958033100682 -2.4873 -0.9945 3188924 PK04_108307 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(Br)cc5)C(C)(C)C4CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P10 compound treatment 8620760.0 -1650000.0 -1.42 8152760.0 -1440000.0 -1.19 8797520.0 -1186202.53968254 -0.997453579245158 -2.086 -0.9898 3071127 PK04_108308 OC[C@H]1C(=C(COc2ccccc2)Cn3n1c(=O)n(c4ccccc4)c3=O)[C@H](O)CCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P11 mock treatment 9074840.0 -1200000.0 -1.03 8444800.0 -1150000.0 -0.95 9371040.0 -612682.539682539 -0.515192281000272 -1.4421 -0.9649 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P12 mock treatment 8909840.0 -1360000.0 -1.17 7925880.0 -1670000.0 -1.38 8403040.0 -1580682.53968254 -1.32916378452421 -2.2426 -0.9976 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P13 compound treatment 9065000.0 -1210000.0 -1.04 8692880.0 -900000.0 -0.75 8464040.0 -1519682.53968254 -1.27787012572777 -1.7685 -0.9781 3188925 PK04_108309 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(N)cc5)C(C)(C)C4CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P14 compound treatment 8741520.0 -1530000.0 -1.32 8096320.0 -1500000.0 -1.24 8840720.0 -1143002.53968254 -0.961127578261445 -2.0321 -0.9916 3071425 PK04_108310 CCCC[C@@H](O)C1=C(C)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P15 compound treatment 8612560.0 -1660000.0 -1.43 8433880.0 -1160000.0 -0.96 1.082872E7 844997.460317461 0.710541170711276 -0.9693 -0.5205 3188926 PK04_108311 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(nc5)C(F)(F)F)C(C)(C)C4CC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P16 compound treatment 8588440.0 -1680000.0 -1.45 8780680.0 -812000.0 -0.67 7833160.0 -2150562.53968254 -1.80836428083436 -2.2695 -0.9405 3215868 PK04_108312 CCCC[C@@H](O)C1=C(COC)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P17 compound treatment 8661880.0 -1610000.0 -1.39 7880840.0 -1710000.0 -1.42 7724240.0 -2259482.53968254 -1.89995289257385 -2.7169 -0.989 3188927 PK04_108313 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)F)C(=O)N(C)c3ccccc32 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P18 compound treatment 8345400.0 -1930000.0 -1.66 7920640.0 -1670000.0 -1.39 8179040.0 -1804682.53968254 -1.51752082666198 -2.6343 -0.9974 3215866 PK04_108314 CCCC[C@@H](O)C1=C(COc2ccccc2)Cn3n([C@H]1CO)c(=O)n(c4ccccc4)c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P19 compound treatment 8107800.0 -2160000.0 -1.86 8018120.0 -1570000.0 -1.31 8586240.0 -1397482.53968254 -1.17511463220439 -2.508 -0.9795 3071435 PK04_108315 COC(=O)C[C@H]1O[C@@]2(C[C@@H]1[Si](C)(C)C)C(=O)N(C)c3ccccc32 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P20 compound treatment 8230680.0 -2040000.0 -1.76 7778960.0 -1810000.0 -1.5 8020840.0 -1962882.53968254 -1.65054798767178 -2.8359 -0.998 3071437 PK04_108316 OB1OC(CCc2ccccc2)CC=C1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P21 compound treatment 8030000.0 -2240000.0 -1.93 7621480.0 -1970000.0 -1.64 8399960.0 -1583762.53968254 -1.33175369385361 -2.827 -0.989 3188929 PK04_108317 COC(=O)C/C=C/C[C@]1(O)C(=O)N(C)c2ccccc21 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P22 compound treatment 7584720.0 -2690000.0 -2.31 7472280.0 -2120000.0 -1.76 1.043384E7 450117.460317461 0.378494613571262 -2.1323 -0.7277 3071483 PK04_108318 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)c2ccncc2)c3ccccc3)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P23 compound treatment 6795720.0 -3480000.0 -2.99 6342160.0 -3250000.0 -2.7 6894840.0 -3088882.53968254 -2.59737847627505 -4.7838 -0.9982 3188930 PK04_108319 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO[Si](C(C)C)(C(C)C)C(C)C)nn2)/C=C/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2108 P24 compound treatment 4574480.0 -5700000.0 -4.9 4852160.0 -4740000.0 -3.93 4820600.0 -5163122.53968254 -4.34156468647081 -7.6081 -0.9959 3071486 PK04_108320 CC(=O)OC(C/C=C\B1OC(C)(C)C(C)(C)O1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A01 compound treatment 4481240.0 -4210000.0 -3.62 5065480.0 -4600000.0 -3.82 5625200.0 -4259792.55813953 -3.58197288558773 -6.3613 -0.9996 3221174 PK04_130001 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N[C@@H]3[C@H](O)Cc4ccccc34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A02 compound treatment 6261520.0 -2430000.0 -2.09 6568560.0 -3100000.0 -2.57 7469400.0 -2415592.55813953 -2.03122263063024 -3.8614 -0.9942 3211805 PK04_130002 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A03 compound treatment 6980280.0 -1710000.0 -1.47 7618880.0 -2050000.0 -1.7 8453480.0 -1431512.55813953 -1.2037297822957 -2.5235 -0.9905 3221177 PK04_130003 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCc4ccccc4F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A04 compound treatment 7451520.0 -1240000.0 -1.06 7903720.0 -1760000.0 -1.46 8516120.0 -1368872.55813953 -1.15105708086931 -2.1225 -0.9905 3080218 PK04_130004 OCCC[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A05 compound treatment 7020720.0 -1670000.0 -1.43 8287120.0 -1380000.0 -1.14 8406680.0 -1478312.55813953 -1.24308295002805 -2.206 -0.9955 3221180 PK04_130005 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccc(O)cc2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A06 compound treatment 7465600.0 -1220000.0 -1.05 8661680.0 -1000000.0 -0.83 8744160.0 -1140832.55813953 -0.959302884935843 -1.6417 -0.9955 3211801 PK04_130006 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A07 compound treatment 7512960.0 -1170000.0 -1.01 8002280.0 -1660000.0 -1.38 8820040.0 -1064952.55813953 -0.895496936911673 -1.8972 -0.9827 3221183 PK04_130007 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccccc2O)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A08 compound treatment 5514280.0 -3170000.0 -2.73 5921240.0 -3740000.0 -3.11 6574000.0 -3310992.55813953 -2.78414627138989 -4.9775 -0.9983 3080220 PK04_130008 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A09 compound treatment 7106200.0 -1580000.0 -1.36 7424440.0 -2240000.0 -1.86 8200960.0 -1684032.55813953 -1.41606871211994 -2.6766 -0.9898 3221185 PK04_130009 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccc(O)cc2)c3coc4ccccc4c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A10 compound treatment 7234600.0 -1450000.0 -1.25 8049080.0 -1620000.0 -1.34 8688960.0 -1196032.55813953 -1.00571944174837 -2.0767 -0.9931 3080222 PK04_130010 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A11 compound treatment 4563600.0 -4120000.0 -3.55 2058000.0 -7610000.0 -6.31 3954400.0 -5930592.55813953 -4.98691460881893 -8.5719 -0.975 3221188 PK04_130011 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccc(Cl)cc2)c3coc4ccccc4c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A12 compound treatment 7838120.0 -850000.0 -0.73 7863440.0 -1800000.0 -1.49 8275160.0 -1609832.55813953 -1.3536754419118 -2.0667 -0.9635 3211814 PK04_130012 C[C@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A13 mock treatment 7901480.0 -786000.0 -0.68 7754320.0 -1910000.0 -1.59 8315920.0 -1569072.55813953 -1.31940118727995 -2.0676 -0.9526 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A14 mock treatment 7345120.0 -1340000.0 -1.16 8683560.0 -981000.0 -0.81 8283360.0 -1601632.55813953 -1.34678022876212 -1.9148 -0.9807 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A15 compound treatment 7454920.0 -1230000.0 -1.06 8272640.0 -1390000.0 -1.16 8165000.0 -1719992.55813953 -1.44630674442027 -2.1146 -0.9911 3221191 PK04_130013 OCCCCCCNC(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2coc3ccccc3c2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A16 compound treatment 8093000.0 -595000.0 -0.51 8807280.0 -858000.0 -0.71 8262800.0 -1622192.55813953 -1.36406871441548 -1.494 -0.9214 3080206 PK04_130014 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A17 compound treatment 7435400.0 -1250000.0 -1.08 8738080.0 -927000.0 -0.77 8539080.0 -1345912.55813953 -1.13175048405019 -1.7197 -0.9873 3221194 PK04_130015 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N[C@@H]4[C@H](O)Cc5ccccc45 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A18 compound treatment 7423080.0 -1260000.0 -1.09 8442240.0 -1220000.0 -1.01 8718160.0 -1166832.55813953 -0.981165755898263 -1.7806 -0.999 3211690 PK04_130016 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A19 compound treatment 6466120.0 -2220000.0 -1.91 7322640.0 -2340000.0 -1.94 7306000.0 -2578992.55813953 -2.16862236583253 -3.4779 -0.9984 3221197 PK04_130017 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccccc2F)c3coc4ccccc4c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A20 compound treatment 6731240.0 -1960000.0 -1.68 7565080.0 -2100000.0 -1.74 8125200.0 -1759792.55813953 -1.47977375458582 -2.8324 -0.9976 3189020 PK04_130018 C[C@@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A21 compound treatment 6438720.0 -2250000.0 -1.94 7543600.0 -2120000.0 -1.76 6992200.0 -2892792.55813953 -2.43249040075589 -3.538 -0.9904 2019329 PK04_130019 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N3CCCCCCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A22 compound treatment 7196960.0 -1490000.0 -1.28 8257040.0 -1410000.0 -1.17 7474000.0 -2410992.55813953 -2.0273545842292 -2.5857 -0.969 3080190 PK04_130020 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A23 compound treatment 7077120.0 -1610000.0 -1.39 7170240.0 -2490000.0 -2.07 6792200.0 -3092792.55813953 -2.60066633123604 -3.4967 -0.971 3221200 PK04_130021 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCCCCCC2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 A24 compound treatment 4110040.0 -4580000.0 -3.94 5250800.0 -4410000.0 -3.66 5915400.0 -3969592.55813953 -3.33794961046103 -6.3161 -0.9977 3211695 PK04_130022 CO[C@@H](CCO)[C@@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B01 compound treatment 7291520.0 -1400000.0 -1.2 7897440.0 -1770000.0 -1.47 8607960.0 -1277032.55813953 -1.07383069359283 -2.1604 -0.9915 3176327 PK04_130023 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B02 compound treatment 7118040.0 -1570000.0 -1.35 8725880.0 -939000.0 -0.78 9101840.0 -783152.558139529 -0.658537050865137 -1.61 -0.951 3221203 PK04_130024 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B03 compound treatment 8177360.0 -510000.0 -0.44 9387040.0 -278000.0 -0.23 9900880.0 15887.4418604709 0.0133594265891702 -0.3791 -0.7637 3052745 PK04_130025 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B04 compound treatment 7889440.0 -798000.0 -0.69 8719200.0 -946000.0 -0.78 9545800.0 -339192.558139529 -0.285220120385294 -1.0144 -0.9381 3221205 PK04_130026 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B05 compound treatment 8308760.0 -379000.0 -0.33 9561880.0 -103000.0 -0.09 9585440.0 -299552.558139529 -0.251887650964127 -0.3832 -0.9103 3176512 PK04_130027 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B06 compound treatment 8434760.0 -253000.0 -0.22 9756920.0 91900.0 0.08 9874400.0 -10592.5581395291 -0.00890706660640211 -0.0869 -0.3763 3221207 PK04_130028 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(C)c3ccccc32)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B07 compound treatment 8622280.0 -65600.0 -0.06 9193040.0 -472000.0 -0.39 9608320.0 -276672.558139529 -0.232648324517198 -0.393 -0.8562 3176123 PK04_130029 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B08 compound treatment 8572720.0 -115000.0 -0.1 9768520.0 103000.0 0.09 1.034712E7 462127.441860471 0.388593562676488 0.2167 0.5284 3221209 PK04_130030 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B09 compound treatment 8345400.0 -342000.0 -0.29 1.02872E7 622000.0 0.52 9890040.0 5047.44186047092 0.00424429115714586 0.1303 0.2192 3052645 PK04_130031 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B10 compound treatment 7867920.0 -820000.0 -0.71 9762160.0 97100.0 0.08 1.008844E7 203447.441860471 0.171074814193458 -0.2621 -0.3588 3221211 PK04_130032 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B11 compound treatment 8678840.0 -9010.0 -0.01 9230680.0 -434000.0 -0.36 1.01394E7 254407.441860471 0.213926041279801 -0.089 -0.2124 3052831 PK04_130033 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B12 compound treatment 8123600.0 -564000.0 -0.49 9726880.0 61800.0 0.05 1.010392E7 218927.441860471 0.184091631212622 -0.1445 -0.2768 3221213 PK04_130034 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B13 mock treatment 8727480.0 39600.0 0.03 9808080.0 143000.0 0.12 1.007372E7 188727.441860471 0.158697065710118 0.1798 0.8943 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B14 mock treatment 8801640.0 114000.0 0.1 9863560.0 199000.0 0.16 1.015212E7 267127.441860471 0.224622030458338 0.2813 0.9528 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B15 compound treatment 8446080.0 -242000.0 -0.21 9396720.0 -268000.0 -0.22 9415720.0 -469272.558139529 -0.394601745569585 -0.4765 -0.9557 3176778 PK04_130035 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B16 compound treatment 8507240.0 -181000.0 -0.16 9751000.0 86000.0 0.07 9944480.0 59487.4418604709 0.0500217794338435 -0.0197 -0.1105 3221214 PK04_130036 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccccc32)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B17 compound treatment 8092040.0 -596000.0 -0.51 9914680.0 250000.0 0.21 1.020484E7 319847.441860471 0.268953205732907 -0.0212 -0.0345 3176195 PK04_130037 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B18 compound treatment 8543920.0 -144000.0 -0.12 9996960.0 332000.0 0.28 1.011028E7 225287.441860471 0.18943962580189 0.1968 0.5522 3221216 PK04_130038 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(CC=C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B19 compound treatment 8327760.0 -360000.0 -0.31 9903640.0 239000.0 0.2 9905960.0 20967.4418604709 0.017631095223366 -0.0545 -0.148 3052584 PK04_130039 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B20 compound treatment 8905040.0 217000.0 0.19 9892840.0 228000.0 0.19 9500120.0 -384872.558139529 -0.323631502906961 0.0302 0.072 3221218 PK04_130040 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B21 compound treatment 8327440.0 -360000.0 -0.31 9685320.0 20300.0 0.02 9043600.0 -841392.558139529 -0.707509881820958 -0.5779 -0.7478 3176736 PK04_130041 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B22 compound treatment 7283320.0 -1400000.0 -1.21 8520880.0 -1140000.0 -0.95 7622280.0 -2262712.55813953 -1.90266894937121 -2.3444 -0.9585 3221220 PK04_130042 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(C)c3c2cc(C)cc3Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B23 compound treatment 8181600.0 -506000.0 -0.44 1.002072E7 356000.0 0.3 9584080.0 -300912.558139529 -0.253031247291392 -0.2273 -0.3893 3052927 PK04_130043 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 B24 compound treatment 6897920.0 -1790000.0 -1.54 7515240.0 -2150000.0 -1.78 8226560.0 -1658432.55813953 -1.39454219301848 -2.7242 -0.9948 3221222 PK04_130044 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C01 compound treatment 5954880.0 -2730000.0 -2.35 6734200.0 -2930000.0 -2.43 7274120.0 -2610872.55813953 -2.19542960915106 -4.0293 -0.9991 3221224 PK04_130045 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCc3ccc(Cl)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C02 compound treatment 6875560.0 -1810000.0 -1.56 8150520.0 -1510000.0 -1.26 8784200.0 -1100792.55813953 -0.925634063653716 -2.1603 -0.9791 3211914 PK04_130046 COc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C03 compound treatment 8566560.0 -121000.0 -0.1 9277720.0 -387000.0 -0.32 9485680.0 -399312.558139529 -0.335773805087628 -0.4396 -0.923 3221227 PK04_130047 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCOCCOCCOCCOCC2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C04 compound treatment 8593400.0 -94500.0 -0.08 9744760.0 79700.0 0.07 9902880.0 17887.4418604709 0.0150411858939717 -1.0E-4 -7.0E-4 3211809 PK04_130048 CSc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C05 compound treatment 8761960.0 74100.0 0.06 9752880.0 87800.0 0.07 1.042972E7 544727.441860471 0.458050221964791 0.3433 0.7334 2019446 PK04_130049 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2coc3ccccc3c2=O)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C06 compound treatment 8286480.0 -401000.0 -0.35 1.00812E7 416000.0 0.35 1.03212E7 436207.441860471 0.36679796208626 0.2116 0.3465 3069417 PK04_130050 C[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C07 compound treatment 8660960.0 -26900.0 -0.02 9685600.0 20600.0 0.02 1.074316E7 858167.441860471 0.721615540213287 0.4131 0.572 3221230 PK04_130051 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccc(O)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C08 compound treatment 8560440.0 -127000.0 -0.11 9595240.0 -69800.0 -0.06 9890920.0 5927.44186047092 0.00498426525125853 -0.0939 -0.7563 3080227 PK04_130052 CSc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C09 compound treatment 8624720.0 -63100.0 -0.05 1.001028E7 345000.0 0.29 1.024788E7 362887.441860471 0.305144665972236 0.3102 0.735 3221232 PK04_130053 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)O)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C10 compound treatment 9075040.0 387000.0 0.33 9869640.0 205000.0 0.17 1.027E7 385007.441860471 0.323744923883341 0.4773 0.965 3080226 PK04_130054 COc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C11 mock treatment 9154640.0 467000.0 0.4 9706520.0 41500.0 0.03 1.028544E7 400447.441860471 0.336728105716408 0.4462 0.8494 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C12 mock treatment 9332200.0 644000.0 0.55 9943680.0 279000.0 0.23 1.013492E7 249927.441860471 0.210158900437045 0.575 0.9033 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C13 compound treatment 8392080.0 -296000.0 -0.25 1.00126E7 348000.0 0.29 1.038752E7 502527.441860471 0.422565100633479 0.2635 0.4611 3221235 PK04_130055 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCCCCCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C14 compound treatment 7978920.0 -709000.0 -0.61 9397720.0 -267000.0 -0.22 9329040.0 -555952.558139529 -0.467489193839683 -0.7502 -0.9378 3080272 PK04_130056 OCCC[C@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C15 mock treatment 8397400.0 -290000.0 -0.25 9889560.0 225000.0 0.19 9655360.0 -229632.558139529 -0.193093345668266 -0.1483 -0.4044 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C16 mock treatment 8061280.0 -627000.0 -0.54 9401800.0 -263000.0 -0.22 9866640.0 -18352.5581395291 -0.015432292709032 -0.4463 -0.7669 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C17 compound treatment 8634240.0 -53600.0 -0.05 1.030344E7 638000.0 0.53 1.038048E7 495487.441860471 0.416645307880577 0.5197 0.7694 3221238 PK04_130057 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccc(O)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C18 compound treatment 8253680.0 -434000.0 -0.37 9277080.0 -388000.0 -0.32 9005840.0 -879152.558139529 -0.739261497495611 -0.8284 -0.9322 3080228 PK04_130058 OCCC[C@@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C19 compound treatment 8717080.0 29200.0 0.03 1.02304E7 565000.0 0.47 1.006568E7 180687.441860471 0.151936393304816 0.373 0.7557 2019457 PK04_130059 Nc1ccccc1NC(=O)C2=C[C@@H](C[C@H](OCCCCO)O2)c3coc4ccccc4c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C20 compound treatment 8394760.0 -293000.0 -0.25 9444520.0 -221000.0 -0.18 9709520.0 -175472.558139529 -0.14755130369424 -0.3364 -0.9758 3080205 PK04_130060 OCCC[C@@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C21 compound treatment 8978760.0 291000.0 0.25 9456560.0 -208000.0 -0.17 9402240.0 -482752.558139529 -0.405936803283947 -0.1897 -0.3739 3221241 PK04_130061 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)c4cccs4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C22 compound treatment 8587040.0 -101000.0 -0.09 9441080.0 -224000.0 -0.19 9244720.0 -640272.558139529 -0.538392166130116 -0.4682 -0.8127 3211908 PK04_130062 COc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C23 compound treatment 8246480.0 -441000.0 -0.38 9575200.0 -89800.0 -0.07 9382920.0 -502072.558139529 -0.42218259816833 -0.5061 -0.8836 2019323 PK04_130063 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccccc3O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 C24 compound treatment 7029720.0 -1660000.0 -1.43 8135600.0 -1530000.0 -1.27 8383040.0 -1501952.55813953 -1.26296134501081 -2.2856 -0.9983 3211812 PK04_130064 C[C@@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D01 compound treatment 8116880.0 -571000.0 -0.49 9532880.0 -132000.0 -0.11 9164040.0 -720952.558139529 -0.60623433648581 -0.697 -0.8845 3175965 PK04_130065 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D02 compound treatment 2932800.0 -5760000.0 -4.95 4206880.0 -5460000.0 -4.53 4432040.0 -5452952.55813953 -4.58527685164623 -8.1211 -0.9992 3221243 PK04_130066 COc1cc2c3N(C(=O)[C@@]42O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)C(C)(C)C=C(C)c3c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D03 compound treatment 8023080.0 -665000.0 -0.57 9476080.0 -189000.0 -0.16 9964960.0 79967.4418604709 0.0672429947150112 -0.382 -0.6399 3176379 PK04_130067 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D04 compound treatment 7987880.0 -700000.0 -0.6 9710400.0 45400.0 0.04 9171240.0 -713752.558139529 -0.600180002988524 -0.6726 -0.7902 3221245 PK04_130068 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(C)c3ccccc32)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D05 compound treatment 8500560.0 -187000.0 -0.16 9720720.0 55700.0 0.05 9845680.0 -39312.5581395291 -0.0330571302233521 -0.0855 -0.5002 3052839 PK04_130069 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D06 compound treatment 8297360.0 -390000.0 -0.34 9265480.0 -400000.0 -0.33 9547800.0 -337192.558139529 -0.283538361080492 -0.5491 -0.9972 3221246 PK04_130070 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(C)c5c4cc(C)cc5Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D07 compound treatment 8463960.0 -224000.0 -0.19 9907880.0 243000.0 0.2 1.051848E7 633487.441860471 0.532686699911883 0.3126 0.5199 3176048 PK04_130071 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D08 compound treatment 8718280.0 30400.0 0.03 9690720.0 25700.0 0.02 9827160.0 -57832.5581395291 -0.0486302213858143 -7.0E-4 -0.0112 3221248 PK04_130072 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D09 compound treatment 8691560.0 3710.0 0.0 9793600.0 129000.0 0.11 1.098832E7 1103327.44186047 0.927765595795858 0.5991 0.6415 3175970 PK04_130073 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D10 compound treatment 8713400.0 25500.0 0.02 9309320.0 -356000.0 -0.3 1.09852E7 1100207.44186047 0.925142051280368 0.3764 0.3876 3221250 PK04_130074 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D11 mock treatment 8512280.0 -176000.0 -0.15 9609120.0 -55900.0 -0.05 9825720.0 -59272.5581395291 -0.0498410880852714 -0.1428 -0.8616 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D12 mock treatment 9054400.0 367000.0 0.32 1.004716E7 382000.0 0.32 1.07308E7 845807.441860471 0.711222267709613 0.7758 0.9234 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D13 compound treatment 8514120.0 -174000.0 -0.15 1.011712E7 452000.0 0.38 1.018188E7 296887.441860471 0.249646608913785 0.2743 0.5779 3176675 PK04_130075 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D14 compound treatment 8868960.0 181000.0 0.16 9892960.0 228000.0 0.19 1.05932E7 708207.441860471 0.595517227539268 0.543 0.8432 3221251 PK04_130076 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D15 mock treatment 8765800.0 77900.0 0.07 9596720.0 -68300.0 -0.06 9770200.0 -114792.558139529 -0.0965267263865618 -0.0497 -0.381 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D16 mock treatment 8822800.0 135000.0 0.12 1.032784E7 663000.0 0.55 9947400.0 62407.4418604709 0.0524771480188537 0.4148 0.7349 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D17 compound treatment 8977160.0 289000.0 0.25 9668360.0 3310.0 0.0 1.083376E7 948767.441860471 0.797799236720796 0.6059 0.725 3052531 PK04_130077 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D18 compound treatment 9254120.0 566000.0 0.49 1.07524E7 1090000.0 0.9 1.09588E7 1073807.44186047 0.902942828456988 1.3235 0.9687 3221253 PK04_130078 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D19 compound treatment 8649920.0 -37900.0 -0.03 1.076296E7 1100000.0 0.91 1.063668E7 751687.441860471 0.632078674825653 0.8719 0.7861 3052793 PK04_130079 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D20 compound treatment 9571800.0 884000.0 0.76 9669280.0 4230.0 0.0 1.023036E7 345367.441860471 0.290412454462174 0.6089 0.7478 3221255 PK04_130080 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D21 compound treatment 9020040.0 332000.0 0.29 1.03564E7 691000.0 0.57 1.005864E7 173647.441860471 0.146016600551915 0.5805 0.8832 3052828 PK04_130081 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D22 compound treatment 8777880.0 90000.0 0.08 1.002244E7 357000.0 0.3 9693720.0 -191272.558139529 -0.160837202202172 0.123 0.3555 3221256 PK04_130082 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D23 compound treatment 8449160.0 -239000.0 -0.21 9451000.0 -214000.0 -0.18 9803880.0 -81112.5581395291 -0.0682058996937041 -0.2605 -0.9305 3052592 PK04_130083 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 D24 compound treatment 7721280.0 -967000.0 -0.83 8493480.0 -1170000.0 -0.97 8690080.0 -1194912.55813953 -1.00477765653768 -1.6215 -0.9968 3221257 PK04_130084 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(C)c3c2cc(C)cc3Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E01 mock treatment 7658400.0 -1030000.0 -0.89 8978880.0 -686000.0 -0.57 9411160.0 -473832.558139529 -0.398436156784533 -1.0702 -0.9505 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E02 mock treatment 8769880.0 82000.0 0.07 9619920.0 -45100.0 -0.04 9354920.0 -530072.558139529 -0.445727228435552 -0.2382 -0.526 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E03 compound treatment 7037960.0 -1650000.0 -1.42 8417120.0 -1250000.0 -1.04 9156400.0 -728592.558139529 -0.612658657030152 -1.7712 -0.9518 2019322 PK04_130085 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccccc3N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E04 compound treatment 8171360.0 -516000.0 -0.44 9522480.0 -143000.0 -0.12 1.028684E7 401847.441860471 0.337905337229769 -0.1298 -0.2275 3080210 PK04_130086 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E05 compound treatment 8526520.0 -161000.0 -0.14 9318960.0 -346000.0 -0.29 9733040.0 -151952.558139529 -0.127773814269774 -0.3197 -0.9305 3221259 PK04_130087 OCCCCCCNC(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E06 compound treatment 8482640.0 -205000.0 -0.18 1.025792E7 593000.0 0.49 1.052368E7 638687.441860471 0.537059274104367 0.4921 0.6567 3211802 PK04_130088 OCCC[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E07 compound treatment 8481320.0 -207000.0 -0.18 9230040.0 -435000.0 -0.36 1.08934E7 1008407.44186047 0.847949299189978 0.1786 0.1903 3221261 PK04_130089 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCc4ccc(Cl)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E08 compound treatment 8145680.0 -542000.0 -0.47 9695280.0 30200.0 0.03 9987840.0 102847.441860471 0.0864823211619407 -0.205 -0.4314 3080219 PK04_130090 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E09 mock treatment 9010400.0 323000.0 0.28 1.013232E7 467000.0 0.39 1.038832E7 503327.441860471 0.423237804355399 0.6284 0.9857 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E10 mock treatment 8931760.0 244000.0 0.21 9763320.0 98300.0 0.08 1.03078E7 422807.441860471 0.35553017474409 0.3735 0.8876 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E11 compound treatment 8890960.0 203000.0 0.17 9639880.0 -25200.0 -0.02 1.049744E7 612447.441860471 0.514994592025371 0.3862 0.7096 3221264 PK04_130091 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cc(=O)n(c3ccccc3)n2C)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E12 compound treatment 9232920.0 545000.0 0.47 9574560.0 -90500.0 -0.08 1.052264E7 637647.441860471 0.53618475926587 0.5371 0.7497 3069920 PK04_130092 O[C@@H](CC=C)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E13 compound treatment 8748120.0 60300.0 0.05 1.071884E7 1050000.0 0.87 1.03322E7 447207.441860471 0.376047638262668 0.7518 0.7888 3221266 PK04_130093 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccccc4N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E14 compound treatment 8933360.0 246000.0 0.21 9722800.0 57800.0 0.05 1.031788E7 432887.441860471 0.364006241640289 0.3598 0.8494 3211678 PK04_130094 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E15 compound treatment 8640840.0 -47000.0 -0.04 9641880.0 -23200.0 -0.02 1.018228E7 297287.441860471 0.249982960774745 0.1099 0.4326 3221269 PK04_130095 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N4CCOCCOCCOCCOCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E16 compound treatment 7669920.0 -1020000.0 -0.88 5997800.0 -3670000.0 -3.04 5115120.0 -4769872.55813953 -4.01088877868432 -4.5779 -0.8959 3211906 PK04_130096 CSc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E17 mock treatment 8667320.0 -20500.0 -0.02 9813920.0 149000.0 0.12 1.02412E7 356207.441860471 0.299527589894199 0.234 0.7213 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E18 mock treatment 8348120.0 -340000.0 -0.29 9055600.0 -609000.0 -0.51 1.002224E7 137247.441860471 0.115408581204527 -0.3941 -0.6619 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E19 compound treatment 8772560.0 84700.0 0.07 9938000.0 273000.0 0.23 1.004212E7 157127.441860471 0.132125268694254 0.2491 0.9155 2019458 PK04_130097 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccccc2O)c3coc4ccccc4c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E20 compound treatment 9060400.0 373000.0 0.32 9605920.0 -59100.0 -0.05 9920600.0 35607.4418604709 0.0299415733345132 0.1741 0.5344 3211804 PK04_130098 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E21 compound treatment 9025640.0 338000.0 0.29 9722840.0 57800.0 0.05 9617000.0 -267992.558139529 -0.225349489134359 0.0654 0.1764 3221271 PK04_130099 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccccc2F)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E22 compound treatment 8522800.0 -165000.0 -0.14 9693480.0 28400.0 0.02 9664120.0 -220872.558139529 -0.185727239913235 -0.1756 -0.7473 3211680 PK04_130100 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E23 compound treatment 8962520.0 275000.0 0.24 8916800.0 -748000.0 -0.62 9851520.0 -33472.5581395291 -0.0281463930533316 -0.2381 -0.3582 2019464 PK04_130101 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCCCCCC2)c3coc4ccccc4c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 E24 compound treatment 7826040.0 -862000.0 -0.74 8132600.0 -1530000.0 -1.27 8410800.0 -1474192.55813953 -1.23961852586016 -1.8779 -0.9759 3211909 PK04_130102 CSc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F01 mock treatment 7383200.0 -1300000.0 -1.12 9010960.0 -654000.0 -0.54 9022480.0 -862512.558139529 -0.725269260079662 -1.3803 -0.9568 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F02 mock treatment 8745480.0 57600.0 0.05 9824880.0 160000.0 0.13 9560360.0 -324632.558139529 -0.272976912646338 -0.0524 -0.1705 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F03 compound treatment 8337000.0 -351000.0 -0.3 9908440.0 243000.0 0.2 9873480.0 -11512.5581395291 -0.00968067588661081 -0.0634 -0.1743 3176785 PK04_130103 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F04 compound treatment 8202840.0 -485000.0 -0.42 9871280.0 206000.0 0.17 9357600.0 -527392.558139529 -0.443473670967118 -0.3983 -0.6296 3221273 PK04_130104 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(C)c5c4cc(C)cc5Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F05 compound treatment 7991080.0 -697000.0 -0.6 9987560.0 323000.0 0.27 1.06268E7 741807.441860471 0.623770783859934 0.1684 0.1859 3176500 PK04_130105 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F06 compound treatment 8515160.0 -173000.0 -0.15 9715320.0 50300.0 0.04 1.029144E7 406447.441860471 0.341773383630813 0.1356 0.3616 3221274 PK04_130106 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(CC=C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F07 compound treatment 8451800.0 -236000.0 -0.2 9965520.0 300000.0 0.25 1.052716E7 642167.441860471 0.539985535294721 0.3384 0.5384 3052886 PK04_130107 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F08 compound treatment 8884800.0 197000.0 0.17 1.03904E7 725000.0 0.6 1.017092E7 285927.441860471 0.240430567923473 0.5841 0.872 3221275 PK04_130108 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(c3ccccc32)c4ccccc4)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F09 mock treatment 8793520.0 106000.0 0.09 9506880.0 -158000.0 -0.13 9924400.0 39407.4418604709 0.0331369160136362 -0.0041 -0.0253 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F10 mock treatment 8542560.0 -145000.0 -0.13 9847240.0 182000.0 0.15 1.028524E7 400247.441860471 0.336559929785928 0.2094 0.5375 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F11 compound treatment 8466600.0 -221000.0 -0.19 9072040.0 -593000.0 -0.49 1.0045E7 160007.441860471 0.134547002093168 -0.3163 -0.581 3052654 PK04_130109 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F12 compound treatment 9002000.0 314000.0 0.27 1.013948E7 474000.0 0.39 1.035168E7 466687.441860471 0.392427973891435 0.6099 0.9868 3221277 PK04_130110 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F13 compound treatment 8342400.0 -345000.0 -0.3 9708520.0 43500.0 0.04 1.029704E7 412047.441860471 0.346482309684257 0.0492 0.1075 3052647 PK04_130111 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F14 compound treatment 8874080.0 186000.0 0.16 1.02234E7 558000.0 0.46 1.01812E7 296207.441860471 0.249074810750153 0.5038 0.9163 3221279 PK04_130112 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F15 compound treatment 8864640.0 177000.0 0.15 1.000464E7 340000.0 0.28 1.041104E7 526047.441860471 0.442342590057945 0.5059 0.9264 3176113 PK04_130113 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F16 compound treatment 9326520.0 639000.0 0.55 8945000.0 -720000.0 -0.6 9468840.0 -416152.558139529 -0.349934218434056 -0.2296 -0.2597 3221280 PK04_130114 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(CC=C)c5ccccc54)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F17 mock treatment 9348160.0 660000.0 0.57 9766600.0 102000.0 0.08 1.003384E7 148847.441860471 0.125162785172376 0.449 0.7636 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F18 mock treatment 9119560.0 432000.0 0.37 9675640.0 10600.0 0.01 1.001388E7 128887.441860471 0.108378827310457 0.2822 0.7288 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F19 compound treatment 9199360.0 512000.0 0.44 9936640.0 272000.0 0.23 1.008988E7 204887.441860471 0.172285680892915 0.4837 0.9237 3052888 PK04_130115 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F20 compound treatment 4449800.0 -4240000.0 -3.65 4433400.0 -5230000.0 -4.34 4976360.0 -4908632.55813953 -4.12756923925145 -6.9946 -0.9974 3221282 PK04_130116 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(c3ccccc32)c4ccccc4)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F21 compound treatment 8139080.0 -549000.0 -0.47 9823720.0 159000.0 0.13 1.074336E7 858367.441860471 0.721783716143767 0.22 0.2522 3176499 PK04_130117 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F22 compound treatment 9044840.0 357000.0 0.31 1.006392E7 399000.0 0.33 1.000912E7 124127.441860471 0.104376240165029 0.4287 0.925 3221283 PK04_130118 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F23 compound treatment 7359760.0 -1330000.0 -1.14 9572080.0 -93000.0 -0.08 9654480.0 -230512.558139529 -0.193833319762378 -0.8164 -0.7026 3175968 PK04_130119 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 F24 compound treatment 8113480.0 -574000.0 -0.49 8746400.0 -919000.0 -0.76 8707440.0 -1177552.55813953 -0.990179985771999 -1.2971 -0.9653 3221284 PK04_130120 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G01 compound treatment 7552480.0 -1140000.0 -0.98 9144680.0 -520000.0 -0.43 8435400.0 -1449592.55813953 -1.2189328864111 -1.5171 -0.936 2019328 PK04_130121 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N3CCOCCOCCOCCOCC3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G02 compound treatment 1992080.0 -6700000.0 -5.76 3517200.0 -6150000.0 -5.1 2693720.0 -7191272.55813953 -6.04699476900753 -9.7628 -0.9975 3211907 PK04_130122 COc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G03 mock treatment 8414360.0 -273000.0 -0.24 1.009704E7 432000.0 0.36 1.032424E7 439247.441860471 0.369354236229558 0.2843 0.5023 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G04 mock treatment 8861960.0 174000.0 0.15 9729080.0 64000.0 0.05 9792880.0 -92112.5581395291 -0.0774555758701125 0.0725 0.4097 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G05 compound treatment 8681800.0 -6050.0 -0.01 1.009564E7 431000.0 0.36 1.064116E7 756167.441860471 0.635845815668409 0.5703 0.782 3221285 PK04_130123 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCCCCCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G06 compound treatment 8726840.0 39000.0 0.03 1.006788E7 403000.0 0.33 9971840.0 86847.4418604709 0.0730282467235285 0.2545 0.7404 3211815 PK04_130124 COc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G07 compound treatment 8625720.0 -62100.0 -0.05 9983600.0 319000.0 0.26 9589800.0 -295192.558139529 -0.24822141567966 -0.0216 -0.059 3221287 PK04_130125 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCc3ccccc3F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G08 compound treatment 8795880.0 108000.0 0.09 1.020768E7 543000.0 0.45 9540960.0 -344032.558139529 -0.289289977902913 0.1466 0.2698 3211803 PK04_130126 CSc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G09 compound treatment 8264920.0 -423000.0 -0.36 1.004888E7 384000.0 0.32 1.029132E7 406327.441860471 0.341672478072525 0.171 0.2887 3221289 PK04_130127 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N4CCCCCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G10 compound treatment 8919640.0 232000.0 0.2 9643280.0 -21800.0 -0.02 9448600.0 -436392.558139529 -0.366953622598648 -0.1071 -0.2562 3211807 PK04_130128 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G11 compound treatment 8769800.0 81900.0 0.07 1.012692E7 462000.0 0.38 9481680.0 -403312.558139529 -0.339137323697231 0.0661 0.128 2019311 PK04_130129 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2ccc(cc2)C(=O)OC)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G12 compound treatment 8793640.0 106000.0 0.09 9912000.0 247000.0 0.2 1.030424E7 419247.441860471 0.352536643181543 0.3744 0.8961 3211818 PK04_130130 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G13 compound treatment 8760280.0 72400.0 0.06 1.04258E7 761000.0 0.63 1.034148E7 456487.441860471 0.383851001436947 0.622 0.839 3221292 PK04_130131 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccccc4O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G14 compound treatment 8629840.0 -58000.0 -0.05 1.0188E7 523000.0 0.43 1.061248E7 727487.441860471 0.611729387237555 0.5748 0.7648 3080207 PK04_130132 OCCC[C@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G15 compound treatment 8384560.0 -303000.0 -0.26 9908520.0 243000.0 0.2 1.020948E7 324487.441860471 0.272854887320046 0.1234 0.2883 2019470 PK04_130133 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)O)c2coc3ccccc3c2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G16 compound treatment 8826400.0 139000.0 0.12 1.03502E7 685000.0 0.57 9448040.0 -436952.558139529 -0.367424515203992 0.1849 0.269 3080225 PK04_130134 COc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G17 compound treatment 9008640.0 321000.0 0.28 1.023444E7 569000.0 0.47 9875920.0 -9072.55813952908 -0.00762892953475294 0.4277 0.7817 3221294 PK04_130135 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)c4coc5ccccc5c4=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G18 compound treatment 8897760.0 210000.0 0.18 1.040904E7 744000.0 0.62 1.00824E7 197407.441860471 0.165995901092957 0.5565 0.8379 3211806 PK04_130136 CO[C@@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G19 mock treatment 8982800.0 295000.0 0.25 9999320.0 334000.0 0.28 9848560.0 -36432.5581395291 -0.0306353968244379 0.289 0.7661 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G20 mock treatment 8724480.0 36600.0 0.03 9641280.0 -23800.0 -0.02 1.057696E7 691967.441860471 0.58186134198428 0.3428 0.5879 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G21 compound treatment 8965320.0 277000.0 0.24 9780680.0 116000.0 0.1 1.01216E7 236607.441860471 0.198958383467067 0.3081 0.9472 2019463 PK04_130137 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCOCCOCCOCCOCC2)c3coc4ccccc4c3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G22 compound treatment 8256640.0 -431000.0 -0.37 9458720.0 -206000.0 -0.17 9302360.0 -582632.558139529 -0.489923862965736 -0.5959 -0.9341 3080280 PK04_130138 COc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G23 compound treatment 8555600.0 -132000.0 -0.11 9732520.0 67500.0 0.06 9630520.0 -254472.558139529 -0.213980796233901 -0.1569 -0.6309 3221297 PK04_130139 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 G24 compound treatment 8249040.0 -439000.0 -0.38 8572920.0 -1090000.0 -0.91 8268080.0 -1616912.55813953 -1.3596288698508 -1.5261 -0.9101 3211912 PK04_130140 C[C@H](CCO)[C@@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H01 compound treatment 7411600.0 -1280000.0 -1.1 9528160.0 -137000.0 -0.11 9371280.0 -513712.558139529 -0.431970437322275 -0.9491 -0.8004 3052931 PK04_130141 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H02 compound treatment 7982680.0 -705000.0 -0.61 9361600.0 -303000.0 -0.25 9309400.0 -575592.558139529 -0.484004070212834 -0.7752 -0.9499 3221300 PK04_130142 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H03 mock treatment 8523400.0 -164000.0 -0.14 9528920.0 -136000.0 -0.11 1.016828E7 283287.441860471 0.238210645641135 -0.0094 -0.0314 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H04 mock treatment 8706840.0 19000.0 0.02 9871360.0 206000.0 0.17 9859040.0 -25952.5581395291 -0.0218229780672779 0.0956 0.5519 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H05 compound treatment 8403560.0 -284000.0 -0.24 1.001804E7 353000.0 0.29 1.009548E7 210487.441860471 0.176994606946359 0.13 0.309 3176330 PK04_130143 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H06 compound treatment 8342680.0 -345000.0 -0.3 1.05974E7 932000.0 0.77 9266080.0 -618912.558139529 -0.520430976754836 -0.0254 -0.026 3221301 PK04_130144 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H07 compound treatment 8585600.0 -102000.0 -0.09 9993040.0 328000.0 0.27 1.007784E7 192847.441860471 0.16216148987801 0.1999 0.6081 3176685 PK04_130145 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H08 compound treatment 8668520.0 -19300.0 -0.02 1.0894E7 1230000.0 1.02 9956760.0 71767.4418604709 0.0603477815653249 0.6138 0.601 3221302 PK04_130146 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H09 compound treatment 8563160.0 -125000.0 -0.11 9602080.0 -63000.0 -0.05 1.041E7 525007.441860471 0.441468075219448 0.1628 0.3559 3052879 PK04_130147 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H10 compound treatment 9072920.0 385000.0 0.33 1.06212E7 956000.0 0.79 1.099356E7 1108567.44186047 0.932171805174438 1.1875 0.9365 3221303 PK04_130148 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H11 compound treatment 9610000.0 922000.0 0.79 9565640.0 -99400.0 -0.08 1.044216E7 557167.441860471 0.468510764840656 0.6811 0.7361 3176775 PK04_130149 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H12 compound treatment 9242680.0 555000.0 0.48 1.003656E7 372000.0 0.31 1.082132E7 936327.441860471 0.78733869384493 0.9082 0.9353 3221305 PK04_130150 COc1cc2c3N(C(=O)[C@]42O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)O)C(C)(C)C=C(C)c3c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H13 compound treatment 9223440.0 536000.0 0.46 9601080.0 -64000.0 -0.05 9950560.0 65567.4418604709 0.0551343277204402 0.2673 0.5721 3052783 PK04_130151 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H14 compound treatment 9049920.0 362000.0 0.31 9832000.0 167000.0 0.14 9957920.0 72927.4418604709 0.0613232019621098 0.2953 0.8522 3221307 PK04_130152 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(CC=C)c5ccccc54)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H15 compound treatment 8610360.0 -77500.0 -0.07 9670320.0 5270.0 0.0 1.041748E7 532487.441860471 0.447757855019405 0.2225 0.4915 3176626 PK04_130153 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H16 compound treatment 8320640.0 -367000.0 -0.32 9146360.0 -519000.0 -0.43 1.041012E7 525127.441860471 0.441568980777736 -0.176 -0.254 3221308 PK04_130154 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccccc32)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H17 compound treatment 8686240.0 -1610.0 0.0 9812720.0 148000.0 0.12 1.05514E7 666407.441860471 0.560368458068916 0.3935 0.6859 3176501 PK04_130155 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H18 compound treatment 8995920.0 308000.0 0.27 1.017544E7 510000.0 0.42 1.007556E7 190567.441860471 0.160244284270536 0.49 0.9341 3221309 PK04_130156 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H19 mock treatment 8989440.0 302000.0 0.26 9902800.0 238000.0 0.2 1.072984E7 844847.441860471 0.710415023243308 0.6739 0.8621 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H20 mock treatment 8681400.0 -6450.0 -0.01 1.080856E7 1140000.0 0.95 1.0616E7 731007.441860471 0.614689283614005 0.8994 0.7956 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H21 compound treatment 8795520.0 108000.0 0.09 9858360.0 193000.0 0.16 1.070116E7 816167.441860471 0.686298594812454 0.5423 0.7629 3052741 PK04_130157 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H22 compound treatment 8500720.0 -187000.0 -0.16 7585160.0 -2080000.0 -1.73 8743560.0 -1141432.55813953 -0.959807412727283 -1.6433 -0.8295 3221310 PK04_130158 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H23 compound treatment 8862400.0 175000.0 0.15 9869120.0 204000.0 0.17 1.03666E7 481607.441860471 0.404973898305254 0.4183 0.9016 3176203 PK04_130159 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 H24 compound treatment 8254840.0 -433000.0 -0.37 8777840.0 -887000.0 -0.74 8942280.0 -942712.558139529 -0.792707808202203 -1.0978 -0.9595 3221312 PK04_130160 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I01 compound treatment 7806920.0 -881000.0 -0.76 8588280.0 -1080000.0 -0.89 8799440.0 -1085552.55813953 -0.912819057751129 -1.4805 -0.9968 3221313 PK04_130161 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccc(Cl)cc2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I02 compound treatment 8664640.0 -23200.0 -0.02 9668880.0 3830.0 0.0 9823600.0 -61392.5581395291 -0.051623752948361 -0.0395 -0.7125 3080209 PK04_130162 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I03 compound treatment 7944840.0 -743000.0 -0.64 9837040.0 172000.0 0.14 9274240.0 -610752.558139529 -0.513569398791245 -0.5833 -0.7007 3221314 PK04_130163 Nc1ccccc1NC(=O)C2=C[C@@H](C[C@H](OCCCCO)O2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I04 compound treatment 8741640.0 53800.0 0.05 9407320.0 -258000.0 -0.21 9950600.0 65607.4418604709 0.0551679629065362 -0.0649 -0.2875 3069956 PK04_130164 CO[C@@H](C=C)[C@@H](O)c1ccc(OC)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I05 mock treatment 8250480.0 -437000.0 -0.38 1.018276E7 518000.0 0.43 9608680.0 -276312.558139529 -0.232345607842333 -0.1035 -0.1679 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I06 mock treatment 8522680.0 -165000.0 -0.14 1.048304E7 818000.0 0.68 9807680.0 -77312.5581395291 -0.0650105570145812 0.2722 0.3909 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I07 compound treatment 8469680.0 -218000.0 -0.19 9744520.0 79500.0 0.07 1.053064E7 645647.441860471 0.542911796485076 0.2431 0.4204 3221316 PK04_130165 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cccs2)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I08 compound treatment 8909680.0 222000.0 0.19 9392240.0 -273000.0 -0.23 1.063816E7 753167.441860471 0.633323176711206 0.3452 0.4938 3211693 PK04_130166 CO[C@H](CCO)[C@H](O)c1ccc(O)c(F)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I09 compound treatment 8905840.0 218000.0 0.19 9806560.0 142000.0 0.12 1.0308E7 423007.441860471 0.35569835067457 0.3815 0.9106 2019335 PK04_130167 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I10 compound treatment 8640480.0 -47400.0 -0.04 1.026632E7 601000.0 0.5 1.032188E7 436887.441860471 0.367369760249892 0.4765 0.7676 3080278 PK04_130168 CSc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I11 compound treatment 8872800.0 185000.0 0.16 1.049644E7 831000.0 0.69 1.016924E7 284247.441860471 0.239017890107439 0.6281 0.8407 3221318 PK04_130169 COc1cc2c[n+](Cc3cc4OCOc4cc3Br)ccc2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I12 compound treatment 8816240.0 128000.0 0.11 1.014916E7 484000.0 0.4 1.110048E7 1215487.44186047 1.02207865760913 0.8858 0.8025 3211911 PK04_130170 COc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I13 compound treatment 8519000.0 -169000.0 -0.15 9619960.0 -45100.0 -0.04 9942080.0 57087.4418604709 0.0480036682680817 -0.0778 -0.4937 3221319 PK04_130171 COc1cc2c[n+](Cc3sc4ccccc4c3Cl)ccc2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I14 compound treatment 9687160.0 999000.0 0.86 1.012404E7 459000.0 0.38 9762880.0 -122112.558139529 -0.102681965442135 0.6571 0.6945 3080208 PK04_130172 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I15 compound treatment 8842480.0 155000.0 0.13 9862400.0 197000.0 0.16 9965640.0 80647.4418604709 0.0678147928786437 0.2105 0.9499 3221320 PK04_130173 COc1cc2c[n+](Cc3ccc(o3)[N+](=O)[O-])ccc2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I16 compound treatment 9078480.0 391000.0 0.34 1.002588E7 361000.0 0.3 1.049984E7 614847.441860471 0.517012703191132 0.6654 0.9707 3080223 PK04_130174 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I17 compound treatment 8861240.0 173000.0 0.15 1.029428E7 629000.0 0.52 1.054608E7 661087.441860471 0.555894978318144 0.7085 0.9118 3221321 PK04_130175 COc1cc2c[n+](Cc3cccc(OC(F)(F)F)c3)ccc2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I18 compound treatment 7745240.0 -943000.0 -0.81 6650320.0 -3010000.0 -2.5 6244520.0 -3640472.55813953 -3.06119929926289 -3.6797 -0.9119 3080282 PK04_130176 CSc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I19 compound treatment 8843680.0 156000.0 0.13 9872200.0 207000.0 0.17 1.060964E7 724647.441860471 0.609341289024737 0.5284 0.8166 3221322 PK04_130177 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3cccs3)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I20 compound treatment 8849080.0 161000.0 0.14 1.046544E7 800000.0 0.66 1.024356E7 358567.441860471 0.301512065873864 0.6375 0.8589 3211594 PK04_130178 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I21 mock treatment 8922720.0 235000.0 0.2 1.011744E7 452000.0 0.38 1.039608E7 511087.441860471 0.429763030458029 0.5815 0.9607 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I22 mock treatment 8850680.0 163000.0 0.14 9614200.0 -50800.0 -0.04 1.035628E7 471287.441860471 0.396296020292479 0.2854 0.6755 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I23 compound treatment 8902760.0 215000.0 0.18 9512400.0 -153000.0 -0.13 9944920.0 59927.4418604709 0.0503917664808999 0.0628 0.2732 3221324 PK04_130179 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cc3OCOc3cc2Br)c4cccs4)CCCO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 I24 compound treatment 8006880.0 -681000.0 -0.59 8412360.0 -1250000.0 -1.04 9058720.0 -826272.558139529 -0.694795781476658 -1.3395 -0.9702 3211811 PK04_130180 CSc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J01 compound treatment 7490840.0 -1200000.0 -1.03 8654920.0 -1010000.0 -0.84 8776480.0 -1108512.55813953 -0.93212565457025 -1.6168 -0.9965 3176788 PK04_130181 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J02 compound treatment 6256040.0 -2430000.0 -2.09 7552000.0 -2110000.0 -1.75 7488120.0 -2396872.55813953 -2.0154813635373 -3.384 -0.9972 3221326 PK04_130182 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCOC5=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J03 compound treatment 7900960.0 -787000.0 -0.68 9943080.0 278000.0 0.23 9593120.0 -291872.558139529 -0.245429695233689 -0.3995 -0.5282 3176789 PK04_130183 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J04 compound treatment 8363080.0 -325000.0 -0.28 9610000.0 -55000.0 -0.05 9848000.0 -36992.5581395291 -0.0311062894297823 -0.2057 -0.722 3221328 PK04_130184 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N(C=O)c4ccccc4)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J05 mock treatment 7815960.0 -872000.0 -0.75 9505560.0 -159000.0 -0.13 1.030504E7 420047.441860471 0.353209346903463 -0.3057 -0.364 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J06 mock treatment 8286800.0 -401000.0 -0.35 9962880.0 298000.0 0.25 9935720.0 50727.4418604709 0.0426556736788128 -0.032 -0.075 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J07 compound treatment 8531320.0 -157000.0 -0.13 9160760.0 -504000.0 -0.42 1.006968E7 184687.441860471 0.155299911914419 -0.2296 -0.4927 3052827 PK04_130185 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J08 compound treatment 3561880.0 -5130000.0 -4.41 6178040.0 -3490000.0 -2.89 5476000.0 -4408992.55813953 -3.70743212972593 -6.3576 -0.986 3221330 PK04_130186 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4CCOC4=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J09 compound treatment 8333320.0 -355000.0 -0.31 9945440.0 280000.0 0.23 9778360.0 -106632.558139529 -0.0896651484229716 -0.0936 -0.2377 3052794 PK04_130187 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J10 compound treatment 9211160.0 523000.0 0.45 1.061596E7 951000.0 0.79 1.028716E7 402167.441860471 0.338174418718538 0.9107 0.9396 3221332 PK04_130188 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5cccc6cccc4c56)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J11 compound treatment 8474040.0 -214000.0 -0.18 1.017888E7 514000.0 0.43 9934040.0 49047.4418604709 0.0412429958627795 0.1637 0.3511 3176437 PK04_130189 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J12 compound treatment 8352000.0 -336000.0 -0.29 8900520.0 -765000.0 -0.63 9042360.0 -842632.558139529 -0.708552572589935 -0.9421 -0.9479 3221334 PK04_130190 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCOC4=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J13 compound treatment 9087680.0 400000.0 0.34 9938200.0 273000.0 0.23 9989760.0 104767.441860471 0.0880968100945502 0.3804 0.9028 3176038 PK04_130191 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J14 compound treatment 4115240.0 -4570000.0 -3.94 5387480.0 -4280000.0 -3.55 5879960.0 -4005032.55813953 -3.36775038534211 -6.2652 -0.9979 3221335 PK04_130192 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCC4=O)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J15 compound treatment 8478760.0 -209000.0 -0.18 1.00426E7 378000.0 0.31 9623800.0 -261192.558139529 -0.219631507498034 -0.0499 -0.118 3052796 PK04_130193 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J16 compound treatment 5765880.0 -2920000.0 -2.51 4976480.0 -4690000.0 -3.89 8337480.0 -1547512.55813953 -1.30127182197419 -4.4488 -0.9247 3221337 PK04_130194 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCCCC5=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J17 compound treatment 6724920.0 -1960000.0 -1.69 9516920.0 -148000.0 -0.12 9971680.0 86687.4418604709 0.0728937059791443 -1.0042 -0.5923 3176331 PK04_130195 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J18 compound treatment 7618840.0 -1070000.0 -0.92 5628200.0 -4040000.0 -3.35 9147200.0 -737792.558139529 -0.620394749832239 -2.8228 -0.8001 3221339 PK04_130196 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCC5=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J19 compound treatment 9414640.0 727000.0 0.63 1.033012E7 665000.0 0.55 1.00984E7 213407.441860471 0.179449975531369 0.7833 0.9181 3176671 PK04_130197 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J20 compound treatment 8035680.0 -652000.0 -0.56 9356200.0 -309000.0 -0.26 9946160.0 61167.4418604709 0.0514344572498768 -0.4423 -0.7144 3221341 PK04_130198 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4C(=O)c5ccccc5Oc6ccccc46)c7ccccc72)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J21 mock treatment 7737080.0 -951000.0 -0.82 9883680.0 219000.0 0.18 1.00024E7 117407.441860471 0.0987255289008958 -0.3107 -0.3682 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J22 mock treatment 8636240.0 -51600.0 -0.04 1.003664E7 372000.0 0.31 1.048932E7 604327.441860471 0.508166649247876 0.4457 0.7478 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J23 compound treatment 8225000.0 -463000.0 -0.4 1.015048E7 485000.0 0.4 9849880.0 -35112.5581395291 -0.0295254356832689 -0.0145 -0.0256 3176271 PK04_130199 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 J24 compound treatment 7340440.0 -1350000.0 -1.16 1989280.0 -7680000.0 -6.37 8466040.0 -1418952.55813953 -1.19316833386154 -5.0347 -0.765 3221343 PK04_130200 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5ccccc5Oc6ccccc46)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K01 compound treatment 6904880.0 -1780000.0 -1.53 8254280.0 -1410000.0 -1.17 7857760.0 -2027232.55813953 -1.70465860882388 -2.5458 -0.9887 3221345 PK04_130201 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3cccs3)c4ccc(CO)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K02 compound treatment 7480320.0 -1210000.0 -1.04 8487200.0 -1180000.0 -0.98 8894320.0 -990672.558139529 -0.833036396331344 -1.6451 -0.9959 3211905 PK04_130202 C[C@H](CCO)[C@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K03 compound treatment 4358000.0 -4330000.0 -3.73 5472600.0 -4190000.0 -3.48 5885440.0 -3999552.55813953 -3.36314236484696 -6.1012 -0.9991 3221347 PK04_130203 COc1ccc(CN2CCc3cc(OC)c(O)cc3C2C#Cc4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K04 compound treatment 8201760.0 -486000.0 -0.42 9760520.0 95500.0 0.08 9514720.0 -370272.558139529 -0.311354659981909 -0.3756 -0.712 3211691 PK04_130204 CSc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K05 compound treatment 7329240.0 -1360000.0 -1.17 9922560.0 258000.0 0.21 9650440.0 -234552.558139529 -0.197230473558077 -0.6656 -0.5524 3221348 PK04_130205 COc1cc2CCN(C)C(C#Cc3ccccc3)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K06 compound treatment 8664920.0 -22900.0 -0.02 9635200.0 -29800.0 -0.02 1.01278E7 242807.441860471 0.204171837311952 0.0922 0.4462 3211813 PK04_130206 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K07 mock treatment 8435040.0 -253000.0 -0.22 9693280.0 28200.0 0.02 9526080.0 -358912.558139529 -0.301802267130637 -0.2863 -0.7681 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K08 mock treatment 8710040.0 22200.0 0.02 9406640.0 -258000.0 -0.21 9839600.0 -45392.5581395291 -0.0381696785099487 -0.1348 -0.6166 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K09 compound treatment 6968120.0 -1720000.0 -1.48 8915400.0 -750000.0 -0.62 9082760.0 -802232.558139529 -0.674581034632944 -1.603 -0.9206 3221349 PK04_130207 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C#Cc4ccccc4)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K10 compound treatment 5405520.0 -3280000.0 -2.82 4553480.0 -5110000.0 -4.24 4758240.0 -5126752.55813953 -4.3109819090331 -6.5681 -0.9841 3211817 PK04_130208 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K11 compound treatment 7766120.0 -922000.0 -0.79 8804240.0 -861000.0 -0.71 8776440.0 -1108552.55813953 -0.932159289756346 -1.4085 -0.9939 3221350 PK04_130209 COCC#CC1N(Cc2ccc(OC)cc2)CCc3cc(OC)c(O)cc13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K12 compound treatment 8808520.0 121000.0 0.1 1.048136E7 816000.0 0.68 1.003592E7 150927.441860471 0.126911814849369 0.5242 0.7523 3080279 PK04_130210 C[C@@H](CCO)[C@@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K13 compound treatment 8775120.0 87300.0 0.08 9685720.0 20700.0 0.02 1.009344E7 208447.441860471 0.175279212455461 0.1545 0.8067 3221351 PK04_130211 COCC#CC1N(C)CCc2cc(OC)c(O)cc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K14 compound treatment 8969360.0 282000.0 0.24 1.018704E7 522000.0 0.43 1.015924E7 274247.441860471 0.230609093583432 0.523 0.9559 3080188 PK04_130212 CO[C@H](CCO)[C@H](O)c1ccc(OC)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K15 mock treatment 9113120.0 425000.0 0.37 9910240.0 245000.0 0.2 1.01586E7 273607.441860471 0.230070930605895 0.4616 0.9661 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K16 mock treatment 8858160.0 170000.0 0.15 9364720.0 -300000.0 -0.25 1.04984E7 613407.441860471 0.515801836491675 0.2386 0.4035 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K17 compound treatment 9107960.0 420000.0 0.36 9639240.0 -25800.0 -0.02 9929040.0 44047.4418604709 0.0370385976007757 0.2178 0.5981 3221353 PK04_130213 COCC#CC1N(Cc2ccc(o2)[N+](=O)[O-])CCc3cc(OC)c(O)cc13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K18 compound treatment 9576920.0 889000.0 0.77 9750120.0 85100.0 0.07 1.048836E7 603367.441860471 0.507359404781572 0.7754 0.8421 3080221 PK04_130214 CO[C@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K19 compound treatment 8702200.0 14300.0 0.01 9106000.0 -559000.0 -0.46 9823680.0 -61312.5581395291 -0.0515564825761689 -0.2904 -0.6221 3221354 PK04_130215 COc1ccc(CN2CCc3cc(OC)c(O)cc3C2C#C)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K20 compound treatment 8887040.0 199000.0 0.17 9641760.0 -23300.0 -0.02 1.017396E7 288967.441860471 0.242986842066771 0.2281 0.7655 3211696 PK04_130216 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K21 compound treatment 8200080.0 -488000.0 -0.42 9455120.0 -210000.0 -0.17 9958920.0 73927.4418604709 0.0621640816145106 -0.307 -0.6693 3221356 PK04_130217 COc1cc2CCN(C)C(C#C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K22 compound treatment 8962120.0 274000.0 0.24 9676840.0 11800.0 0.01 9800480.0 -84512.5581395291 -0.0710648905118667 0.1009 0.409 3211816 PK04_130218 COc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K23 mock treatment 8751400.0 63500.0 0.05 9645120.0 -19900.0 -0.02 9864560.0 -20432.5581395291 -0.0171813223860256 0.0121 0.203 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 K24 mock treatment 8403680.0 -284000.0 -0.24 9190480.0 -475000.0 -0.39 8619520.0 -1265472.55813953 -1.06411012481107 -0.9829 -0.8468 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L01 compound treatment 8197200.0 -491000.0 -0.42 9270960.0 -394000.0 -0.33 8931360.0 -953632.558139529 -0.80189021400642 -0.8955 -0.9295 3176382 PK04_130219 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L02 compound treatment 8809640.0 122000.0 0.1 9530120.0 -135000.0 -0.11 9696400.0 -188592.558139529 -0.158583644733738 -0.0957 -0.4337 3221357 PK04_130220 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCCCC4=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L03 compound treatment 8903240.0 215000.0 0.19 1.013348E7 468000.0 0.39 9841840.0 -43152.5581395291 -0.036286108088571 0.3104 0.7185 3176383 PK04_130221 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L04 compound treatment 5134680.0 -3550000.0 -3.06 6670880.0 -2990000.0 -2.48 6911720.0 -2973272.55813953 -2.5001643951811 -4.6431 -0.9951 3221359 PK04_130222 C[C@H](O)C(=O)Nc1ccc2N(CC=C)C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L05 compound treatment 8366120.0 -322000.0 -0.28 1.025416E7 589000.0 0.49 9736560.0 -148432.558139529 -0.124813917893324 0.0502 0.0873 3052642 PK04_130223 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L06 compound treatment 3770040.0 -4920000.0 -4.23 8898920.0 -766000.0 -0.64 5284160.0 -4600832.55813953 -3.86874648224249 -5.0442 -0.8743 3221361 PK04_130224 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4CCC4=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L07 mock treatment 8398400.0 -289000.0 -0.25 9812960.0 148000.0 0.12 1.010768E7 222687.441860471 0.187253338705648 0.0351 0.1049 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L08 mock treatment 8938360.0 251000.0 0.22 9986960.0 322000.0 0.27 1.06206E7 735607.441860471 0.618557330015049 0.6358 0.8988 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L09 compound treatment 8901600.0 214000.0 0.18 9770040.0 105000.0 0.09 1.051824E7 633247.441860471 0.532484888795307 0.4639 0.8138 3176673 PK04_130225 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L10 compound treatment 7253400.0 -1430000.0 -1.23 8497440.0 -1170000.0 -0.97 9076400.0 -808592.558139529 -0.679929029222213 -1.6646 -0.9733 3221363 PK04_130226 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)c5ccccc35)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L11 compound treatment 8472680.0 -215000.0 -0.19 9710320.0 45300.0 0.04 9679840.0 -205152.558139529 -0.172508611777495 -0.1848 -0.7224 3052529 PK04_130227 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L12 compound treatment 8769800.0 81900.0 0.07 1.093244E7 1270000.0 1.05 1.043888E7 553887.441860471 0.465752679580782 0.9166 0.7956 3221365 PK04_130228 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N(C=O)c4ccccc4)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L13 compound treatment 9595640.0 908000.0 0.78 1.033756E7 673000.0 0.56 1.081788E7 932887.441860471 0.784446067840672 1.2261 0.989 3052693 PK04_130229 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L14 compound treatment 7085760.0 -1600000.0 -1.38 6348160.0 -3320000.0 -2.75 6266400.0 -3618592.55813953 -3.04280085246836 -4.1415 -0.9569 3221366 PK04_130230 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L15 mock treatment 9562440.0 875000.0 0.75 1.045544E7 790000.0 0.66 1.020292E7 317927.441860471 0.267338716800297 0.9675 0.9362 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L16 mock treatment 8738880.0 51000.0 0.04 9962600.0 298000.0 0.25 1.027216E7 387167.441860471 0.325561223932526 0.3558 0.866 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L17 compound treatment 9150360.0 463000.0 0.4 9653640.0 -11400.0 -0.01 1.056288E7 677887.441860471 0.570021756478477 0.5535 0.796 3176205 PK04_130231 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L18 compound treatment 6765440.0 -1920000.0 -1.65 7049120.0 -2620000.0 -2.17 8310360.0 -1574632.55813953 -1.32407647814729 -2.9726 -0.98 3221368 PK04_130232 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCOC4=O)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L19 compound treatment 8722600.0 34700.0 0.03 9870920.0 206000.0 0.17 9887920.0 2927.44186047092 0.00246162629405624 0.1173 0.6764 3176125 PK04_130233 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L20 compound treatment 4746320.0 -3940000.0 -3.39 4418120.0 -5250000.0 -4.35 6410520.0 -3474472.55813953 -2.92161327696436 -6.1583 -0.9863 3221370 PK04_130234 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)F)c3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L21 compound treatment 8809080.0 121000.0 0.1 9805520.0 140000.0 0.12 9154120.0 -730872.558139529 -0.614575862637625 -0.2273 -0.3584 3052877 PK04_130235 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L22 compound treatment 7023600.0 -1660000.0 -1.43 4648640.0 -5020000.0 -4.16 8099520.0 -1785472.55813953 -1.50136754405947 -4.0964 -0.8809 3221372 PK04_130236 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(NC(=O)C)cc32)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L23 mock treatment 8605440.0 -82400.0 -0.07 9512120.0 -153000.0 -0.13 9680160.0 -204832.558139529 -0.172239530288727 -0.2136 -0.9479 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 L24 mock treatment 7982440.0 -705000.0 -0.61 8301400.0 -1360000.0 -1.13 8531480.0 -1353512.55813953 -1.13814116940844 -1.6607 -0.968 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M01 compound treatment 6374960.0 -2310000.0 -1.99 6942200.0 -2720000.0 -2.26 7390760.0 -2494232.55813953 -2.09734940649504 -3.6643 -0.9986 3221374 PK04_130237 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C#C)c2cc1O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M02 compound treatment 7936400.0 -751000.0 -0.65 8835800.0 -829000.0 -0.69 9170080.0 -714912.558139529 -0.601155423385309 -1.1176 -0.9985 3211810 PK04_130238 C[C@@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M03 compound treatment 7546080.0 -1140000.0 -0.98 8815240.0 -850000.0 -0.7 8824640.0 -1060352.55813953 -0.891628890510629 -1.4891 -0.9911 3221375 PK04_130239 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M04 compound treatment 8309960.0 -378000.0 -0.33 9205920.0 -459000.0 -0.38 9915680.0 30687.4418604709 0.0258044454447015 -0.3928 -0.7832 3080224 PK04_130240 COc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M05 compound treatment 7868720.0 -819000.0 -0.7 9109400.0 -556000.0 -0.46 9231240.0 -653752.558139529 -0.549727223844478 -0.9905 -0.9848 3221376 PK04_130241 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M06 compound treatment 7685360.0 -1000000.0 -0.86 9673800.0 8750.0 0.01 9795320.0 -89672.5581395291 -0.0754038295182546 -0.5375 -0.6206 3211820 PK04_130242 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M07 compound treatment 8388480.0 -299000.0 -0.26 9105480.0 -560000.0 -0.46 9737120.0 -147872.558139529 -0.124343025287979 -0.4886 -0.896 3221377 PK04_130243 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M08 compound treatment 8353760.0 -334000.0 -0.29 8485480.0 -1180000.0 -0.98 9716360.0 -168632.558139529 -0.141799686871819 -0.8128 -0.7894 3211694 PK04_130244 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M09 mock treatment 9057560.0 370000.0 0.32 9748280.0 83200.0 0.07 9761680.0 -123312.558139529 -0.103691021025016 0.1637 0.4791 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M10 mock treatment 8642360.0 -45500.0 -0.04 9795920.0 131000.0 0.11 9762320.0 -122672.558139529 -0.10315285804748 -0.0195 -0.1258 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M11 compound treatment 8364360.0 -323000.0 -0.28 9618680.0 -46400.0 -0.04 9403520.0 -481472.558139529 -0.404860477328874 -0.4167 -0.8455 3221378 PK04_130245 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M12 compound treatment 9383160.0 695000.0 0.6 1.032816E7 663000.0 0.55 1.044304E7 558047.441860471 0.469250738934769 0.934 0.9952 3080189 PK04_130246 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M13 mock treatment 9127360.0 440000.0 0.38 9309560.0 -355000.0 -0.29 1.054112E7 656127.441860471 0.551724215242236 0.3667 0.5016 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M14 mock treatment 9555400.0 868000.0 0.75 9254040.0 -411000.0 -0.34 1.042352E7 538527.441860471 0.452836768119906 0.4957 0.5287 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M15 compound treatment 8675880.0 -12000.0 -0.01 8815040.0 -850000.0 -0.71 9878880.0 -6112.55813952908 -0.00513992576364668 -0.416 -0.5899 3221379 PK04_130247 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M16 compound treatment 9018480.0 331000.0 0.28 1.00328E7 368000.0 0.31 9986360.0 101367.441860471 0.0852378192763876 0.3896 0.9151 3211679 PK04_130248 CO[C@@H](CCO)[C@@H](O)c1ccc(OC)c(O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M17 compound treatment 9039600.0 352000.0 0.3 8941640.0 -723000.0 -0.6 9494360.0 -390632.558139529 -0.328474969704789 -0.3613 -0.483 3221380 PK04_130249 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M18 compound treatment 8400880.0 -287000.0 -0.25 9673240.0 8190.0 0.01 9857440.0 -27552.5581395291 -0.0231683855111191 -0.152 -0.6127 3211808 PK04_130250 C[C@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M19 mock treatment 8986280.0 298000.0 0.26 9755360.0 90300.0 0.07 9941240.0 56247.4418604709 0.047297329360065 0.2188 0.8055 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M20 compound treatment 8335680.0 -352000.0 -0.3 8784600.0 -880000.0 -0.73 9689080.0 -195912.558139529 -0.164738883789312 -0.6918 -0.8564 3080271 PK04_130251 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M21 mock treatment 8289960.0 -398000.0 -0.34 9555320.0 -110000.0 -0.09 9971080.0 86087.4418604709 0.0723891781877039 -0.2085 -0.5764 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M22 compound treatment 8059920.0 -628000.0 -0.54 9011360.0 -654000.0 -0.54 9950040.0 65047.4418604709 0.0546970703011918 -0.5935 -0.7733 3211910 PK04_130252 C[C@@H](CCO)[C@H](O)c1ccc(O)c2ccccc12 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M23 mock treatment 8566360.0 -121000.0 -0.1 9019880.0 -645000.0 -0.54 9597120.0 -287872.558139529 -0.242066176624086 -0.5091 -0.8533 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 M24 compound treatment 6549920.0 -2140000.0 -1.84 7321080.0 -2340000.0 -1.94 6825840.0 -3059152.55813953 -2.57237913972928 -3.6701 -0.9885 3211692 PK04_130253 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c(F)c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N01 compound treatment 7533320.0 -1150000.0 -0.99 8747440.0 -918000.0 -0.76 8270120.0 -1614872.55813953 -1.3579134753599 -1.7972 -0.9731 3176433 PK04_130254 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N02 compound treatment 799200.0 -7890000.0 -6.79 1224120.0 -8440000.0 -7.0 2129520.0 -7755472.55813953 -6.52141906889204 -11.7277 -0.9996 3221382 PK04_130255 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCCCC5=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N03 compound treatment 8879360.0 192000.0 0.16 9866320.0 201000.0 0.17 9938840.0 53847.4418604709 0.0452792181943032 0.2177 0.9111 3175967 PK04_130256 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N04 compound treatment 8660440.0 -27400.0 -0.02 9901480.0 236000.0 0.2 9433440.0 -451552.558139529 -0.379701358129044 -0.1196 -0.2794 3221383 PK04_130257 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5C(=O)c6ccccc6Oc7ccccc57)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N05 compound treatment 9153000.0 465000.0 0.4 9511040.0 -154000.0 -0.13 1.002152E7 136527.441860471 0.114803147854798 0.2236 0.5134 3052653 PK04_130258 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N06 compound treatment 7543120.0 -1140000.0 -0.99 1.018008E7 515000.0 0.43 9435400.0 -449592.558139529 -0.378053234010338 -0.5404 -0.4747 3221385 PK04_130259 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5cccc6cccc4c56)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N07 compound treatment 8367000.0 -321000.0 -0.28 9617040.0 -48000.0 -0.04 9837160.0 -47832.5581395291 -0.0402214248618066 -0.2056 -0.7295 3052758 PK04_130260 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N08 compound treatment 6420320.0 -2270000.0 -1.95 9233440.0 -432000.0 -0.36 7266680.0 -2618312.55813953 -2.20168575376493 -2.6046 -0.8788 3221386 PK04_130261 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccc(cc3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N09 mock treatment 9202360.0 515000.0 0.44 9585920.0 -79100.0 -0.07 1.013128E7 246287.441860471 0.207098098502306 0.3373 0.6839 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N10 mock treatment 8725120.0 37300.0 0.03 9606120.0 -58900.0 -0.05 1.037708E7 492087.441860471 0.413786317062415 0.2292 0.5484 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N11 compound treatment 9147440.0 460000.0 0.4 9852760.0 188000.0 0.16 9945120.0 60127.4418604709 0.05055994241138 0.3475 0.8117 3176332 PK04_130262 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N12 compound treatment 9149760.0 462000.0 0.4 8097320.0 -1570000.0 -1.3 1.05812E7 696207.441860471 0.585426671710459 -0.1834 -0.1238 3221388 PK04_130263 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N13 mock treatment 8845240.0 157000.0 0.14 9929840.0 265000.0 0.22 9922600.0 37607.4418604709 0.0316233326393148 0.2233 0.8588 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N14 mock treatment 9421080.0 733000.0 0.63 9938520.0 273000.0 0.23 1.111372E7 1228727.44186047 1.03321190420691 1.0918 0.8864 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N15 compound treatment 8678280.0 -9570.0 -0.01 9814400.0 149000.0 0.12 9774880.0 -110112.558139529 -0.0925914096133263 0.0133 0.086 3176440 PK04_130264 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N16 compound treatment 8358160.0 -330000.0 -0.28 9277600.0 -387000.0 -0.32 9967920.0 82927.4418604709 0.0697319984861175 -0.3091 -0.7117 3221389 PK04_130265 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N4C(=O)c5cccc6cccc4c56)c7ccccc72)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N17 compound treatment 8725680.0 37800.0 0.03 9870880.0 206000.0 0.17 9845440.0 -39552.5581395291 -0.0332589413399283 0.0982 0.5547 3174818 PK04_130266 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N18 compound treatment 6506440.0 -2180000.0 -1.88 2450680.0 -7210000.0 -5.98 8205840.0 -1679152.55813953 -1.41196521941622 -5.3545 -0.8328 3221391 PK04_130267 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCOC5=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N19 compound treatment 8563920.0 -124000.0 -0.11 9498520.0 -167000.0 -0.14 9214840.0 -670152.558139529 -0.563517650143851 -0.4667 -0.7911 3052539 PK04_130268 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N20 compound treatment 4505520.0 -4180000.0 -3.6 5123520.0 -4540000.0 -3.77 5421120.0 -4463872.55813953 -3.75357960504968 -6.4205 -0.9998 3221392 PK04_130269 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N(C=O)c5ccccc5)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N21 compound treatment 8562840.0 -125000.0 -0.11 1.008344E7 418000.0 0.35 9720240.0 -164752.558139529 -0.138537073820504 0.0583 0.1499 3052582 PK04_130270 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N22 compound treatment 6151480.0 -2540000.0 -2.18 7203360.0 -2460000.0 -2.04 7310280.0 -2574712.55813953 -2.16502340092025 -3.6893 -0.9996 3221394 PK04_130271 C[C@H](O)C(=O)Nc1ccc(CN2C(=O)[C@@]3(O[C@@H](CCO)[C@@H]([C@H]3C)[Si](C)(C)F)c4ccccc24)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N23 compound treatment 8597280.0 -90600.0 -0.08 9222920.0 -442000.0 -0.37 9237400.0 -647592.558139529 -0.54454740518569 -0.5712 -0.8639 3052791 PK04_130272 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 N24 compound treatment 621200.0 -8070000.0 -6.94 950560.0 -8710000.0 -7.23 1252160.0 -8632832.55813953 -7.25917324072238 -12.3732 -0.9998 3221396 PK04_130273 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(NC(=O)C)c3)c4ccccc42)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O01 mock treatment 7268160.0 -1420000.0 -1.22 7531640.0 -2130000.0 -1.77 7660560.0 -2224432.55813953 -1.87048007627731 -2.8072 -0.9849 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O02 compound treatment 7948480.0 -739000.0 -0.64 8177560.0 -1490000.0 -1.23 8336600.0 -1548392.55813953 -1.3020117960683 -1.8315 -0.9623 3211913 PK04_130274 CSc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O03 mock treatment 8806280.0 118000.0 0.1 9021120.0 -644000.0 -0.53 8731840.0 -1153152.55813953 -0.96966252225342 -0.8094 -0.728 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O04 mock treatment 8411480.0 -276000.0 -0.24 9285120.0 -380000.0 -0.32 9480920.0 -404072.558139529 -0.339776392233055 -0.5155 -0.9895 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O05 mock treatment 8509720.0 -178000.0 -0.15 9079960.0 -585000.0 -0.49 9059720.0 -825272.558139529 -0.693954901824257 -0.7694 -0.894 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O06 mock treatment 8742640.0 54800.0 0.05 8984880.0 -680000.0 -0.56 9993520.0 108527.441860471 0.091258517587577 -0.2459 -0.4287 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O07 mock treatment 9098320.0 410000.0 0.35 9282040.0 -383000.0 -0.32 9977680.0 92687.4418604709 0.0779389838935489 0.0655 0.1361 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O08 mock treatment 8228320.0 -460000.0 -0.4 9307520.0 -358000.0 -0.3 9569520.0 -315472.558139529 -0.265274455030347 -0.5527 -0.9852 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O09 mock treatment 8911120.0 223000.0 0.19 1.026564E7 601000.0 0.5 1.003464E7 149647.441860471 0.125835488894296 0.4712 0.859 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O10 mock treatment 9507440.0 820000.0 0.71 1.015956E7 495000.0 0.41 9854120.0 -30872.5581395291 -0.0259601059570896 0.6291 0.7706 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O11 mock treatment 9515120.0 827000.0 0.71 1.047244E7 807000.0 0.67 1.019352E7 308527.441860471 0.25943444806773 0.9475 0.9369 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O12 mock treatment 9546200.0 858000.0 0.74 1.017068E7 506000.0 0.42 9785640.0 -99352.5581395291 -0.083543544553494 0.6204 0.7269 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O13 mock treatment 9267560.0 580000.0 0.5 9426120.0 -239000.0 -0.2 9433760.0 -451232.558139529 -0.379432276640275 -0.0455 -0.0691 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O14 mock treatment 9833800.0 1150000.0 0.99 1.00604E7 395000.0 0.33 1.048692E7 601927.441860471 0.506148538082115 1.051 0.9091 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O15 mock treatment 8877240.0 189000.0 0.16 1.01532E7 488000.0 0.4 1.0222E7 337007.441860471 0.283382700568104 0.4915 0.9444 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O16 mock treatment 8887600.0 200000.0 0.17 9711440.0 46400.0 0.04 1.025312E7 368127.441860471 0.309550875350816 0.3002 0.8428 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O17 mock treatment 8628600.0 -59300.0 -0.05 1.013332E7 468000.0 0.39 1.00976E7 212607.441860471 0.178777271809449 0.2981 0.6921 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O18 mock treatment 8679000.0 -8850.0 -0.01 9987440.0 322000.0 0.27 9965000.0 80007.4418604709 0.0672766299011072 0.1889 0.6845 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O19 mock treatment 8626080.0 -61800.0 -0.05 9570080.0 -95000.0 -0.08 9984040.0 99047.4418604709 0.0832869784828178 -0.0281 -0.2223 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O20 mock treatment 8259600.0 -428000.0 -0.37 8867360.0 -798000.0 -0.66 9560440.0 -324552.558139529 -0.272909642274146 -0.7524 -0.9345 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O21 mock treatment 8632440.0 -55400.0 -0.05 9496120.0 -169000.0 -0.14 9667720.0 -217272.558139529 -0.182700073164592 -0.2139 -0.9098 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O22 mock treatment 8132160.0 -556000.0 -0.48 8625240.0 -1040000.0 -0.86 9407280.0 -477712.558139529 -0.401698769835848 -1.0061 -0.9447 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O23 mock treatment 7644120.0 -1040000.0 -0.9 8940760.0 -724000.0 -0.6 8913880.0 -971112.558139529 -0.816588790330385 -1.337 -0.987 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 O24 mock treatment 6652680.0 -2040000.0 -1.75 7409760.0 -2260000.0 -1.87 7466800.0 -2418192.55813953 -2.03340891772648 -3.2654 -0.9981 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P01 compound treatment 5511240.0 -3180000.0 -2.73 5805680.0 -3860000.0 -3.2 6541720.0 -3343272.55813953 -2.81128986656938 -5.05 -0.9975 3175838 PK04_130275 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P02 compound treatment 5540400.0 -3150000.0 -2.71 5890320.0 -3770000.0 -3.13 6543880.0 -3341112.55813953 -2.8094735665202 -4.9939 -0.9981 3221398 PK04_130276 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccc(cc3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P03 compound treatment 7519800.0 -1170000.0 -1.01 8743600.0 -921000.0 -0.76 8595720.0 -1289272.55813953 -1.08412306053821 -1.6476 -0.9899 3052740 PK04_130277 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P04 compound treatment 4576280.0 -4110000.0 -3.54 5954480.0 -3710000.0 -3.08 6555320.0 -3329672.55813953 -2.79985390329673 -5.4367 -0.9953 3221399 PK04_130278 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(NC(=O)C)c3)c4ccccc42)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P05 compound treatment 8599080.0 -88800.0 -0.08 9382040.0 -283000.0 -0.23 9686720.0 -198272.558139529 -0.166723359768978 -0.2759 -0.9262 3176784 PK04_130279 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P06 compound treatment 1.082728E7 2140000.0 1.84 9247320.0 -418000.0 -0.35 1.261088E7 2725887.44186047 2.29214328459524 2.1864 0.7385 3221400 PK04_130280 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5C(=O)c6ccccc6Oc7ccccc57)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P07 compound treatment 1.009544E7 1410000.0 1.21 8877680.0 -787000.0 -0.65 8602640.0 -1282352.55813953 -1.0783041733436 -0.3003 -0.1717 3052752 PK04_130281 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P08 compound treatment 5924360.0 -2760000.0 -2.38 7494200.0 -2170000.0 -1.8 7829760.0 -2055232.55813953 -1.7282032390911 -3.4107 -0.9893 3221401 PK04_130282 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCC5=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P09 compound treatment 8396960.0 -291000.0 -0.25 8967600.0 -697000.0 -0.58 9006840.0 -878152.558139529 -0.73842061784321 -0.9049 -0.932 3052788 PK04_130283 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P10 compound treatment 8556480.0 -131000.0 -0.11 9566440.0 -98600.0 -0.08 8728560.0 -1156432.55813953 -0.972420607513295 -0.6739 -0.686 3221402 PK04_130284 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P11 mock treatment 9123720.0 436000.0 0.38 9267440.0 -398000.0 -0.33 8856360.0 -1028632.55813953 -0.864956187936477 -0.4732 -0.4738 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P12 mock treatment 1.206916E7 3380000.0 2.91 9282160.0 -383000.0 -0.32 8691160.0 -1193832.55813953 -1.00386950651308 0.9172 0.2964 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P13 compound treatment 8968960.0 281000.0 0.24 9215960.0 -449000.0 -0.37 8766040.0 -1118952.55813953 -0.940904438141314 -0.6186 -0.5946 3052846 PK04_130285 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P14 compound treatment 3194960.0 -5490000.0 -4.73 7730200.0 -1930000.0 -1.61 4498960.0 -5386032.55813953 -4.52900518530757 -6.2709 -0.9303 3221404 PK04_130286 C[C@H](O)C(=O)Nc1cccc(CN2C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c4ccccc24)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P15 compound treatment 8349160.0 -339000.0 -0.29 9672600.0 7550.0 0.01 8636520.0 -1248472.55813953 -1.04981517072026 -0.7708 -0.7074 3052836 PK04_130287 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P16 compound treatment 8402240.0 -286000.0 -0.25 8358800.0 -1310000.0 -1.08 8888760.0 -996232.558139529 -0.837711687198692 -1.2512 -0.8991 3221406 PK04_130288 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P17 compound treatment 8136360.0 -551000.0 -0.47 8427760.0 -1240000.0 -1.03 8526680.0 -1358312.55813953 -1.14217739173996 -1.5261 -0.9495 3176730 PK04_130289 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P18 compound treatment 6096360.0 -2590000.0 -2.23 9569800.0 -95200.0 -0.08 7774800.0 -2110192.55813953 -1.77441798478705 -2.3578 -0.8269 3221407 PK04_130290 C[C@H](O)C(=O)Nc1ccc(CN2C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c4ccccc24)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P19 compound treatment 8166400.0 -521000.0 -0.45 8464640.0 -1200000.0 -1.0 8198440.0 -1686552.55813953 -1.41818772884399 -1.6528 -0.9233 3052799 PK04_130291 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P20 compound treatment 1899000.0 -6790000.0 -5.84 3182640.0 -6480000.0 -5.38 2477920.0 -7407072.55813953 -6.22845659799561 -10.0741 -0.9982 3221408 PK04_130292 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)c5ccccc35)cc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P21 compound treatment 7748840.0 -939000.0 -0.81 8818840.0 -846000.0 -0.7 7961960.0 -1923032.55813953 -1.61703894904372 -1.8055 -0.931 3176730 PK04_130293 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P22 compound treatment 1192280.0 -7500000.0 -6.45 1228160.0 -8440000.0 -7.0 2209880.0 -7675112.55813953 -6.45384598002511 -11.4915 -0.9992 3221410 PK04_130294 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCC4=O)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P23 compound treatment 6553480.0 -2130000.0 -1.84 7284760.0 -2380000.0 -1.97 8042840.0 -1842152.55813953 -1.54902860275755 -3.0949 -0.9951 3176786 PK04_130295 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2130 P24 compound treatment 709160.0 -7980000.0 -6.87 1165520.0 -8500000.0 -7.05 1418880.0 -8466112.55813953 -7.11898178507412 -12.1456 -0.9999 3221411 PK04_130296 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4C(=O)COc5ccccc45)c6ccccc62)[Si](C)(C)F 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A01 compound treatment 4325640.0 -5290000.0 -4.55 4673600.0 -4910000.0 -4.08 4132880.0 -4465577.5 -3.75501325596868 -7.1507 -0.9968 3561840 PK04_181001 CC(C)(C)N(CC=C)C(=O)C1N(Cc2ccccc2)C(=O)C3C(C4OC13C=C4)C(=O)O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A02 compound treatment 5098800.0 -4520000.0 -3.89 6194080.0 -3390000.0 -2.81 5293280.0 -3305177.5 -2.77925650732283 -5.475 -0.987 3561841 PK04_181002 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A03 compound treatment 7036680.0 -2580000.0 -2.22 6774920.0 -2810000.0 -2.33 6273680.0 -2324777.5 -1.95485809610912 -3.7579 -0.9973 3561843 PK04_181003 OC1CCC(CC1)N2C(C(=O)N(CC=C)c3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A04 compound treatment 7064280.0 -2550000.0 -2.2 7769440.0 -1820000.0 -1.51 7143600.0 -1454857.5 -1.22336006889265 -2.8455 -0.9704 2065615 PK04_181004 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A05 compound treatment 7130640.0 -2490000.0 -2.14 6432680.0 -3150000.0 -2.62 6090600.0 -2507857.5 -2.10880634287065 -3.964 -0.9949 3561844 PK04_181005 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccco4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A06 compound treatment 6432200.0 -3190000.0 -2.74 5567320.0 -4020000.0 -3.33 6592600.0 -2005857.5 -1.68668475736547 -4.4818 -0.967 3561845 PK04_181006 CCCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)c5ccccc5Cl)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A07 compound treatment 7147560.0 -2470000.0 -2.13 6830960.0 -2760000.0 -2.29 6769680.0 -1828777.5 -1.53778178851834 -3.4351 -0.9871 3561847 PK04_181007 Cc1cccc2OC(CC(=O)c12)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A08 compound treatment 7827840.0 -1790000.0 -1.54 7583280.0 -2000000.0 -1.66 6744000.0 -1854457.5 -1.55937557799199 -2.7493 -0.9994 3561848 PK04_181008 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A09 compound treatment 3448640.0 -6170000.0 -5.31 5013360.0 -4570000.0 -3.79 4535760.0 -4062697.5 -3.41623966160946 -7.2282 -0.9813 3561850 PK04_181009 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A10 compound treatment 8289120.0 -1330000.0 -1.14 7572080.0 -2010000.0 -1.67 7017880.0 -1580577.5 -1.32907545879247 -2.3925 -0.9877 3561851 PK04_181010 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A11 compound treatment 7907000.0 -1710000.0 -1.47 6146680.0 -3440000.0 -2.85 5928960.0 -2669497.5 -2.24472612988471 -3.7937 -0.9683 3561853 PK04_181011 Brc1ccc(CN(C(C(=O)NCc2ccccc2)c3ccco3)C(=O)Cc4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A12 compound treatment 7354920.0 -2260000.0 -1.95 7245280.0 -2340000.0 -1.94 7199080.0 -1399377.5 -1.17670806577745 -2.9252 -0.9778 3561854 PK04_181012 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A13 mock treatment 7347480.0 -2270000.0 -1.95 8174720.0 -1410000.0 -1.17 7002240.0 -1596217.5 -1.34222681655602 -2.5793 -0.9755 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A14 mock treatment 7496720.0 -2120000.0 -1.83 7677840.0 -1910000.0 -1.58 7410680.0 -1187777.5 -0.99877793132945 -2.5448 -0.9732 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A15 compound treatment 5174200.0 -4440000.0 -3.82 5550800.0 -4040000.0 -3.35 5453160.0 -3145297.5 -2.644816668497 -5.668 -0.9892 3561850 PK04_181013 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A16 compound treatment 7490880.0 -2130000.0 -1.83 7783120.0 -1800000.0 -1.5 7194040.0 -1404417.5 -1.18094609922555 -2.6025 -0.9848 3561856 PK04_181014 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A17 compound treatment 7833840.0 -1780000.0 -1.54 7587480.0 -2000000.0 -1.66 6968120.0 -1630337.5 -1.37091763029593 -2.6355 -0.997 3561858 PK04_181015 COc1ccc(CNC(=O)OCC2c3ccccc3-c4ccccc24)cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A18 compound treatment 7957800.0 -1660000.0 -1.43 7703480.0 -1880000.0 -1.56 7383160.0 -1215297.5 -1.02191893936352 -2.3168 -0.9856 3561856 PK04_181016 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A19 compound treatment 7780840.0 -1840000.0 -1.58 7557120.0 -2030000.0 -1.68 7030720.0 -1567737.5 -1.31827856405564 -2.6459 -0.995 3561859 PK04_181017 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4cc(OC)cc(OC)c4)C(=O)C13)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A20 compound treatment 7272440.0 -2350000.0 -2.02 7122400.0 -2460000.0 -2.04 6819160.0 -1779297.5 -1.49617506331755 -3.2095 -0.9908 3561860 PK04_181018 COc1ccc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A21 compound treatment 6641360.0 -2980000.0 -2.56 6875240.0 -2710000.0 -2.25 6063600.0 -2534857.5 -2.13151009348547 -4.0083 -0.9969 3561861 PK04_181019 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4ccccc4)C(=O)C13)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A22 compound treatment 7097640.0 -2520000.0 -2.17 7455440.0 -2130000.0 -1.77 6503280.0 -2095177.5 -1.7617921279179 -3.2902 -0.995 3561862 PK04_181020 COc1cc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)ccc1O[SiH](C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A23 compound treatment 6995320.0 -2620000.0 -2.26 6519880.0 -3070000.0 -2.54 6132600.0 -2465857.5 -2.07348939746982 -3.9691 -0.9964 3561864 PK04_181021 O=C(Cc1ccccc1)OC(C(=O)NCc2ccccc2)c3ccco3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 A24 compound treatment 5825360.0 -3790000.0 -3.26 6678160.0 -2910000.0 -2.41 5750640.0 -2847817.5 -2.39467178950082 -4.66 -0.9888 3561865 PK04_181022 COc1cc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)ccc1O[SiH](C(C)C)C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B01 compound treatment 7806160.0 -1810000.0 -1.56 7358640.0 -2230000.0 -1.85 7034480.0 -1563977.5 -1.31511685656262 -2.7266 -0.9906 3561867 PK04_181023 OC(CC=C)c1cccc(c1)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B02 compound treatment 6683480.0 -2930000.0 -2.53 6837440.0 -2750000.0 -2.28 6799920.0 -1798537.5 -1.51235358782974 -3.648 -0.9796 1008566 PK04_181024 Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B03 compound treatment 3784680.0 -5830000.0 -5.02 6506600.0 -3080000.0 -2.55 6802120.0 -1796337.5 -1.51050365259446 -5.2457 -0.8995 3561868 PK04_181025 CC(C)(C)OC(=O)OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B04 compound treatment 7186160.0 -2430000.0 -2.09 5638080.0 -3950000.0 -3.28 4320680.0 -4277777.5 -3.59709605724781 -5.1762 -0.9774 3561869 PK04_181026 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)[Se]c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B05 compound treatment 9015720.0 -602000.0 -0.52 7978080.0 -1610000.0 -1.33 7534640.0 -1063817.5 -0.894542489617851 -1.5861 -0.9396 3561870 PK04_181027 OC(CC1CO1)c2ccc(cc2)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B06 compound treatment 8748160.0 -870000.0 -0.75 7731120.0 -1860000.0 -1.54 7884920.0 -713537.5 -0.599999164974911 -1.6673 -0.9193 3561871 PK04_181028 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B07 compound treatment 8680720.0 -937000.0 -0.81 6659720.0 -2930000.0 -2.43 7424880.0 -1173577.5 -0.986837440265359 -2.4373 -0.8888 3561872 PK04_181029 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccc(cc4)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B08 compound treatment 6943320.0 -2670000.0 -2.3 6678280.0 -2910000.0 -2.41 5967680.0 -2630777.5 -2.21216726974375 -3.9991 -0.9994 3561873 PK04_181030 CC(C)CC1CC(=O)C=C(Cl)N1C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B09 compound treatment 9422200.0 -196000.0 -0.17 9531800.0 -54700.0 -0.05 8462080.0 -136377.5 -0.114677064795285 -0.1897 -0.9084 3561874 PK04_181031 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B10 compound treatment 9450680.0 -167000.0 -0.14 9901800.0 315000.0 0.26 7953920.0 -644537.5 -0.541978468959258 -0.245 -0.396 3561875 PK04_181032 COC(=O)C1=C(Cl)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B11 compound treatment 9085560.0 -532000.0 -0.46 8930640.0 -656000.0 -0.54 8512040.0 -86417.5 -0.0726667173613431 -0.6206 -0.868 3561876 PK04_181033 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B12 compound treatment 3839600.0 -5780000.0 -4.97 3736920.0 -5850000.0 -4.85 4325680.0 -4272777.5 -3.59289165898581 -7.7473 -0.9904 3561877 PK04_181034 COC(=O)C1=C(OC)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B13 mock treatment 9416760.0 -201000.0 -0.17 9234640.0 -352000.0 -0.29 8638720.0 40262.5 0.0338559170047858 -0.249 -0.7299 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B14 mock treatment 9496200.0 -122000.0 -0.1 9469720.0 -117000.0 -0.1 8832880.0 234422.5 0.197121110314918 -0.0026 -0.0109 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B15 compound treatment 6670040.0 -2950000.0 -2.54 6521200.0 -3070000.0 -2.54 8147240.0 -451217.5 -0.379419614557142 -3.152 -0.8726 3561878 PK04_181035 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B16 compound treatment 2543280.0 -7070000.0 -6.09 2662720.0 -6920000.0 -5.74 2869960.0 -5728497.5 -4.81697698657865 -9.6126 -0.9954 3561879 PK04_181036 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B17 compound treatment 8317600.0 -1300000.0 -1.12 8168960.0 -1420000.0 -1.18 8435280.0 -163177.5 -0.137212639479626 -1.4043 -0.862 3561880 PK04_181037 OC(CC1CO1)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B18 compound treatment 9106800.0 -511000.0 -0.44 9436880.0 -150000.0 -0.12 8404280.0 -194177.5 -0.16327990870405 -0.4199 -0.8651 3561881 PK04_181038 CC(C)(C)OC(=O)NCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B19 compound treatment 9450560.0 -167000.0 -0.14 9300120.0 -286000.0 -0.24 8737560.0 139102.5 0.116968461848077 -0.1528 -0.5069 3561882 PK04_181039 CN(CC(O)CC(O)c1ccccc1)Cc2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B20 compound treatment 8584800.0 -1030000.0 -0.89 8346160.0 -1240000.0 -1.03 7728760.0 -869697.5 -0.731310931493814 -1.5297 -0.9907 3561883 PK04_181040 COc1ccc(CN(C(=C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B21 compound treatment 8693360.0 -925000.0 -0.8 9180920.0 -406000.0 -0.34 8638920.0 40462.5 0.034024092935266 -0.6341 -0.7333 3561884 PK04_181041 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B22 compound treatment 335840.0 -9280000.0 -7.99 298760.0 -9290000.0 -7.7 276960.0 -8321497.5 -6.99737792525384 -13.1005 -0.9985 3561885 PK04_181042 COc1ccc(CNS(=O)(=O)c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-])c(OC)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B23 compound treatment 8506480.0 -1110000.0 -0.96 8394560.0 -1190000.0 -0.99 7564040.0 -1034417.5 -0.869820627837269 -1.6254 -0.9986 3561886 PK04_181043 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccncc3)CC(O2)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 B24 compound treatment 3993880.0 -5620000.0 -4.84 3268040.0 -6320000.0 -5.24 2656520.0 -5941937.5 -4.99645433958707 -8.7055 -0.9995 3561887 PK04_181044 Brc1ccc(cc1)S(=O)(=O)N2C[C@H]2C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C01 compound treatment 7006080.0 -2610000.0 -2.25 6745960.0 -2840000.0 -2.36 7824200.0 -774257.5 -0.651057377468685 -3.0342 -0.9136 3561889 PK04_181045 O=C(Cc1ccccc1)N2CC(=O)Oc3ccccc23 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C02 compound treatment 8474960.0 -1140000.0 -0.98 7575800.0 -2010000.0 -1.67 8174720.0 -423737.5 -0.356312241709169 -1.7367 -0.882 3561890 PK04_181046 CCCCCNC(=O)[C@H]1N(C(=O)[C@@H]2[C@H](C3OC12C=C3)C(=O)OCC)c4ccccc4Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C03 compound treatment 8691880.0 -926000.0 -0.8 7512400.0 -2070000.0 -1.72 8583360.0 -15097.5 -0.0126951805521206 -1.4609 -0.7704 3561892 PK04_181047 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C04 compound treatment 9163800.0 -454000.0 -0.39 8420560.0 -1170000.0 -0.97 8566120.0 -32337.5 -0.0271919457595097 -0.7998 -0.7664 2065568 PK04_181048 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C05 compound treatment 3235800.0 -6380000.0 -5.49 3304200.0 -6280000.0 -5.21 2844040.0 -5754417.5 -4.83877258716888 -8.9738 -0.9987 3561893 PK04_181049 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)OCC=C)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C06 compound treatment 9007280.0 -611000.0 -0.53 8332280.0 -1250000.0 -1.04 8436280.0 -162177.5 -0.136371759827225 -0.9829 -0.8375 2065566 PK04_181050 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C07 compound treatment 9616640.0 -1350.0 0.0 9154760.0 -432000.0 -0.36 8136200.0 -462257.5 -0.388702925919647 -0.4319 -0.8171 3561894 PK04_181051 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)N(CC=C)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C08 compound treatment 9397960.0 -220000.0 -0.19 8958240.0 -628000.0 -0.52 7950920.0 -647537.5 -0.54450110791646 -0.7246 -0.9324 2065605 PK04_181052 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2cccs2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C09 compound treatment 9647240.0 29200.0 0.03 9279560.0 -307000.0 -0.25 8840720.0 242262.5 0.20371360678974 -0.0149 -0.0454 3561895 PK04_181053 O=C(Cc1ccccc1)OC(COCc2ccccc2)C(=O)NCc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C10 compound treatment 9138120.0 -480000.0 -0.41 9226760.0 -360000.0 -0.3 8101720.0 -496737.5 -0.417696456334425 -0.6519 -0.9894 2065603 PK04_181054 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3cccs3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C11 mock treatment 9695400.0 77400.0 0.07 9434640.0 -152000.0 -0.13 8891120.0 292662.5 0.246093941270739 0.1078 0.3791 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C12 mock treatment 1.001656E7 399000.0 0.34 9517920.0 -68600.0 -0.06 9026720.0 428262.5 0.360117222136283 0.3731 0.7454 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C13 compound treatment 9467240.0 -151000.0 -0.13 9062560.0 -524000.0 -0.43 9377120.0 778662.5 0.654761452337511 0.0522 0.0655 3561896 PK04_181055 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C14 compound treatment 9764280.0 146000.0 0.13 9335080.0 -251000.0 -0.21 8736880.0 138422.5 0.116396663684445 0.0195 0.0721 2065601 PK04_181056 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3cccs3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C15 mock treatment 9592800.0 -25200.0 -0.02 9113320.0 -473000.0 -0.39 8949200.0 350742.5 0.294932231482175 -0.0689 -0.1401 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C16 mock treatment 9074800.0 -543000.0 -0.47 8944200.0 -642000.0 -0.53 8329240.0 -269217.5 -0.226379517820203 -0.7082 -0.9518 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C17 compound treatment 8497000.0 -1120000.0 -0.96 8015880.0 -1570000.0 -1.3 8218920.0 -379537.5 -0.319145361073055 -1.4935 -0.9039 3561897 PK04_181057 OC1CCC(CC1)N2C(C(=O)NCc3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C18 compound treatment 9399360.0 -219000.0 -0.19 9263920.0 -323000.0 -0.27 8685360.0 86902.5 0.0730745439927575 -0.2209 -0.6592 3057099 PK04_181058 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3ccco3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C19 compound treatment 8738600.0 -879000.0 -0.76 8541120.0 -1050000.0 -0.87 8072120.0 -526337.5 -0.442586494045488 -1.1932 -0.9676 3561892 PK04_181059 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C20 compound treatment 9078600.0 -539000.0 -0.46 9066000.0 -521000.0 -0.43 8727400.0 128942.5 0.108425124579686 -0.4547 -0.707 3057100 PK04_181060 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3ccco3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C21 compound treatment 8645280.0 -973000.0 -0.84 8571760.0 -1010000.0 -0.84 8427680.0 -170777.5 -0.143603324837872 -1.0523 -0.8799 3561898 PK04_181061 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=C[C@]42O[C@@H]5/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]4C1=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C22 compound treatment 8754720.0 -863000.0 -0.74 8839000.0 -748000.0 -0.62 7825520.0 -772937.5 -0.649947416327516 -1.1622 -0.997 3176076 PK04_181062 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C23 compound treatment 8832080.0 -786000.0 -0.68 8905800.0 -681000.0 -0.56 7771440.0 -827017.5 -0.69542218792935 -1.118 -0.996 3561899 PK04_181063 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 C24 compound treatment 8094400.0 -1520000.0 -1.31 7502760.0 -2080000.0 -1.73 7078440.0 -1520017.5 -1.27815178704308 -2.493 -0.99 2065566 PK04_181064 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D01 compound treatment 8512480.0 -1110000.0 -0.95 8445400.0 -1140000.0 -0.95 7954560.0 -643897.5 -0.541440305981722 -1.4085 -0.9732 3561900 PK04_181065 COCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D02 compound treatment 8767640.0 -850000.0 -0.73 8360760.0 -1230000.0 -1.02 8398640.0 -199817.5 -0.16802246994359 -1.1066 -0.8755 3561901 PK04_181066 COc1cc(OC)c(CNS(=O)(=O)c2ccc(Br)cc2)c(OC)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D03 compound treatment 9648000.0 30000.0 0.03 9085320.0 -501000.0 -0.42 8254840.0 -343617.5 -0.28894096395882 -0.392 -0.7731 3561902 PK04_181067 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D04 compound treatment 9580840.0 -37200.0 -0.03 8538240.0 -1050000.0 -0.87 8616040.0 17582.5 0.0147847664883365 -0.512 -0.5883 3561903 PK04_181068 COc1ccc(CN(C(COC(=O)c2cccc(OC)c2O)C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D05 compound treatment 8900080.0 -718000.0 -0.62 6682160.0 -2900000.0 -2.41 7119880.0 -1478577.5 -1.24330573424759 -2.4656 -0.8867 3215593 PK04_181069 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)NO)cc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D06 compound treatment 9699000.0 81000.0 0.07 8241720.0 -1340000.0 -1.12 8591880.0 -6577.5 -0.00553088591366603 -0.607 -0.5431 3561904 PK04_181070 COC(=O)C1CC=C(CC1C(=O)OC)N(Cc2ccc(OC)cc2)S(=O)(=O)c3ccc(Br)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D07 compound treatment 9463760.0 -154000.0 -0.13 9600600.0 14100.0 0.01 8860560.0 262102.5 0.220396659093372 0.0574 0.2227 3561905 PK04_181071 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CN(C)Cc3ccccc3)CC(O2)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D08 compound treatment 9739520.0 122000.0 0.1 8967640.0 -619000.0 -0.51 9075040.0 476582.5 0.400748526940288 -0.0046 -0.007 3561906 PK04_181072 COc1ccc(CN([C@H](COC(=O)c2ccc(cc2)[N+](=O)[O-])C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D09 compound treatment 1.074144E7 1120000.0 0.97 9867920.0 281000.0 0.23 8655760.0 57302.5 0.0481845062816948 0.7208 0.7239 3561908 PK04_181073 OC(CSc1nc2ccccc2o1)CC(O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D10 compound treatment 8578320.0 -1040000.0 -0.89 8747280.0 -839000.0 -0.7 8102880.0 -495577.5 -0.41672103593764 -1.1591 -0.9597 3561909 PK04_181074 Brc1ccc(cc1)N2C(CN(C2=O)S(=O)(=O)c3ccc(Br)cc3)C=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D11 mock treatment 9539160.0 -78800.0 -0.07 1.045472E7 868000.0 0.72 9476600.0 878142.5 0.738412160158339 0.803 0.7768 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D12 mock treatment 1.013952E7 522000.0 0.45 1.004488E7 458000.0 0.38 9121600.0 523142.5 0.439899883556067 0.7327 0.9974 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D13 compound treatment 1.023036E7 612000.0 0.53 1.091048E7 1320000.0 1.1 9840480.0 1242022.5 1.04439144807393 1.5414 0.9606 3561910 PK04_181075 COC(=O)CCCCCCC(=O)NOCc1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D14 compound treatment 8380560.0 -1240000.0 -1.06 8477520.0 -1110000.0 -0.92 7730880.0 -867577.5 -0.729528266630725 -1.5672 -0.9887 3561911 PK04_181076 COc1ccc(CN([C@H](CI)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D15 mock treatment 1.005184E7 434000.0 0.37 9873280.0 287000.0 0.24 9213520.0 615062.5 0.517193541204746 0.6515 0.957 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D16 mock treatment 1.014092E7 523000.0 0.45 9623400.0 36900.0 0.03 8909680.0 311222.5 0.261700667619297 0.4286 0.8219 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D17 compound treatment 1.021632E7 598000.0 0.51 9708040.0 122000.0 0.1 8906160.0 307702.5 0.258740771242846 0.5049 0.863 3561913 PK04_181077 OC(=O)CCCCCCC(=O)NOCc1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D18 compound treatment 9738760.0 121000.0 0.1 9408160.0 -178000.0 -0.15 8433640.0 -164817.5 -0.138591682109563 -0.1054 -0.4628 3561914 PK04_181078 COc1ccc(CN(C2=CCC3C(C2)C(=O)N(C)C3=O)S(=O)(=O)c4ccc(Br)cc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D19 compound treatment 1.040108E7 783000.0 0.67 1.099892E7 1410000.0 1.17 9114600.0 516142.5 0.434013725989262 1.3162 0.9271 3561915 PK04_181079 OCc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D20 compound treatment 8884680.0 -733000.0 -0.63 8452280.0 -1130000.0 -0.94 7755680.0 -842777.5 -0.708674451251186 -1.3168 -0.9853 3561916 PK04_181080 COCCCN(CC(O)CO)C[C@]1(O)CCC2[C@]1(C)CCC3[C@@]4(C)CC[C@H](O)C[C@@]54C=C[C@]23C(=C5)C(=O)c6ccc(OC)cc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D21 compound treatment 9782440.0 164000.0 0.14 9696520.0 110000.0 0.09 8428640.0 -169817.5 -0.142796080371567 0.052 0.2353 3561917 PK04_181081 O=Cc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D22 compound treatment 9798560.0 181000.0 0.16 1.001328E7 427000.0 0.35 8401320.0 -197137.5 -0.165768912475156 0.1984 0.4717 3561918 PK04_181082 COCCCN(CC(O)CO)C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D23 compound treatment 8817200.0 -801000.0 -0.69 8932880.0 -654000.0 -0.54 8370040.0 -228417.5 -0.192071628002252 -0.8219 -0.9155 3561919 PK04_181083 OC(CN=[N+]=[N-])CC(O)c1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 D24 compound treatment 8342160.0 -1280000.0 -1.1 8349960.0 -1240000.0 -1.03 7608240.0 -990217.5 -0.832653747201155 -1.7069 -0.9936 3561920 PK04_181084 COCCCN(C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C)C(=O)O[C@H]5C[C@@H](C)CC[C@@H]5C(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E01 mock treatment 8277960.0 -1340000.0 -1.15 7610960.0 -1980000.0 -1.64 7766520.0 -831937.5 -0.699559315819162 -2.0159 -0.9498 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E02 mock treatment 9564600.0 -53400.0 -0.05 8859120.0 -727000.0 -0.6 8616800.0 18342.5 0.015423835024161 -0.366 -0.6046 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E03 compound treatment 9196840.0 -421000.0 -0.36 9240800.0 -346000.0 -0.29 8406320.0 -192137.5 -0.161564514213152 -0.4681 -0.9561 3561899 PK04_181085 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E04 compound treatment 9834320.0 216000.0 0.19 9354040.0 -232000.0 -0.19 8994240.0 395782.5 0.332805451026306 0.1883 0.4406 2065568 PK04_181086 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E05 compound treatment 9191920.0 -426000.0 -0.37 9425800.0 -161000.0 -0.13 9001880.0 403422.5 0.339229771570648 -0.0928 -0.1795 3561899 PK04_181087 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E06 compound treatment 9953360.0 335000.0 0.29 8463320.0 -1120000.0 -0.93 8848600.0 250142.5 0.210339738450658 -0.2499 -0.2504 2065570 PK04_181088 O=C(NCc1ccccc1)C(COCc2ccccc2)OC(=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E07 compound treatment 1.063756E7 1020000.0 0.88 1.001124E7 425000.0 0.35 8808600.0 210142.5 0.176704552354628 0.8121 0.8442 3561899 PK04_181089 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E08 compound treatment 9852160.0 234000.0 0.2 8741560.0 -845000.0 -0.7 9022480.0 424022.5 0.356551892410103 -0.0825 -0.1016 2065572 PK04_181090 COc1ccc(NC(=O)C(COCc2ccccc2)OC(=O)c3ccccc3)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E09 mock treatment 1.112284E7 1500000.0 1.3 1.03292E7 743000.0 0.62 9278880.0 680422.5 0.57215343528566 1.4338 0.9285 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E10 mock treatment 1.019916E7 581000.0 0.5 1.013404E7 548000.0 0.45 9676880.0 1078422.5 0.906823536941164 1.0746 0.9502 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E11 compound treatment 9363880.0 -254000.0 -0.22 8649920.0 -937000.0 -0.78 7928680.0 -669777.5 -0.563202271385854 -0.9 -0.9144 3561921 PK04_181091 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E12 compound treatment 9694240.0 76200.0 0.07 1.011872E7 532000.0 0.44 9389640.0 791182.5 0.665289265585568 0.6769 0.8449 2065574 PK04_181092 CC(C)(C)NC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E13 compound treatment 9555360.0 -62600.0 -0.05 9657840.0 71300.0 0.06 9233000.0 634542.5 0.533573876833513 0.3111 0.5766 3561922 PK04_181093 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(Cc4ccc(OC)cc4)C(=O)[C@@H]13)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E14 compound treatment 1.014204E7 524000.0 0.45 1.040828E7 822000.0 0.68 9118160.0 519702.5 0.437007257551809 0.9063 0.9778 2065576 PK04_181094 CCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E15 compound treatment 1.019752E7 580000.0 0.5 1.010728E7 521000.0 0.43 8944400.0 345942.5 0.290896009150652 0.7053 0.9781 3561841 PK04_181095 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E16 compound treatment 9779880.0 162000.0 0.14 1.008144E7 495000.0 0.41 9449160.0 850702.5 0.715338422496462 0.7305 0.8733 2065599 PK04_181096 CCCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E17 mock treatment 1.043148E7 813000.0 0.7 9970760.0 384000.0 0.32 9170800.0 572342.5 0.481271162454185 0.8661 0.9545 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E18 mock treatment 9858520.0 241000.0 0.21 9753920.0 167000.0 0.14 8507840.0 -90617.5 -0.0761984119014263 0.1557 0.5973 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E19 compound treatment 1.033432E7 716000.0 0.62 1.038536E7 799000.0 0.66 8812240.0 213782.5 0.179765354289367 0.8423 0.9128 3561841 PK04_181097 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E20 compound treatment 9959480.0 341000.0 0.29 9508880.0 -77600.0 -0.06 8330200.0 -268257.5 -0.225572273353898 0.0023 0.006 3561923 PK04_181098 CCCNC(=O)COc1ccc(C=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E21 compound treatment 9501160.0 -117000.0 -0.1 9784640.0 198000.0 0.16 8566120.0 -32337.5 -0.0271919457595097 0.0211 0.1087 3561841 PK04_181099 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E22 compound treatment 9776360.0 158000.0 0.14 9521320.0 -65200.0 -0.05 8370600.0 -227857.5 -0.191600735396907 -0.0631 -0.2617 3561924 PK04_181100 CCCNC(=O)Cc1ccc(N)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E23 compound treatment 8547080.0 -1070000.0 -0.92 9107720.0 -479000.0 -0.4 8106800.0 -491657.5 -0.413424787700229 -1.0001 -0.9214 3561841 PK04_181101 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 E24 compound treatment 8987200.0 -631000.0 -0.54 7958840.0 -1630000.0 -1.35 7348520.0 -1249937.5 -1.05104701052268 -1.6998 -0.9469 3561925 PK04_181102 CCOC(=O)/C=C/c1ccccc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F01 mock treatment 8316320.0 -1300000.0 -1.12 7823600.0 -1760000.0 -1.46 8280440.0 -318017.5 -0.26741444485736 -1.6455 -0.884 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F02 mock treatment 9620720.0 2730.0 0.0 9199240.0 -387000.0 -0.32 9194120.0 595662.5 0.500880475948171 0.1051 0.1766 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F03 compound treatment 9440640.0 -177000.0 -0.15 8003200.0 -1580000.0 -1.31 7946640.0 -651817.5 -0.548100072828736 -1.1629 -0.8124 3561927 PK04_181103 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F04 compound treatment 1.034472E7 727000.0 0.63 9075640.0 -511000.0 -0.42 8958360.0 359902.5 0.302634689098166 0.2912 0.3577 1366116 PK04_181104 Brc1ccc2ncnc(NCC=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F05 compound treatment 9167920.0 -450000.0 -0.39 9039800.0 -547000.0 -0.45 8603440.0 4982.5 0.00418968286808681 -0.4831 -0.8099 3561928 PK04_181105 CN(CC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F06 compound treatment 8796760.0 -821000.0 -0.71 6549000.0 -3040000.0 -2.52 7933080.0 -665377.5 -0.55950240091529 -2.1859 -0.8168 1945167 PK04_181106 C/C(=C/C(=O)c1ccc(Cl)cc1)/Nc2cccc(O)c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F07 compound treatment 9682320.0 64300.0 0.06 9811560.0 225000.0 0.19 8951680.0 353222.5 0.297017613020129 0.3112 0.8763 3561929 PK04_181107 OC(CSc1nc2ccccc2s1)CC(O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F08 compound treatment 1.010664E7 489000.0 0.42 9204440.0 -382000.0 -0.32 9156000.0 557542.5 0.468826143598654 0.3305 0.4687 1448632 PK04_181108 Nn1cnc2-c3ccccc3CC4(CCCC4)c2c1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F09 mock treatment 9617880.0 -113.0 0.0 1.023252E7 646000.0 0.54 9377360.0 778902.5 0.654963263454087 0.6875 0.8124 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F10 mock treatment 1.058308E7 965000.0 0.83 1.022532E7 639000.0 0.53 9604160.0 1005702.5 0.84567476861858 1.2738 0.981 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F11 compound treatment 1.0669E7 1050000.0 0.9 9651520.0 65000.0 0.05 9205520.0 607062.5 0.51046650398554 0.8481 0.8154 3561930 PK04_181109 OC(CSc1ccccn1)CC(O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F12 compound treatment 1.009916E7 481000.0 0.41 9691440.0 105000.0 0.09 9232280.0 633822.5 0.532968443483784 0.5971 0.8773 3561931 PK04_181110 [O-][N+](=O)c1ccccc1/C=C/c2ccncc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F13 compound treatment 7098880.0 -2520000.0 -2.17 5606360.0 -3980000.0 -3.3 4881200.0 -3717257.5 -3.12576619448414 -4.9627 -0.9852 3561933 PK04_181111 ONC(=O)CCCCCCC(=O)NOCc1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F14 compound treatment 1.015476E7 537000.0 0.46 1.012156E7 535000.0 0.44 8716400.0 117942.5 0.0991754484032772 0.5802 0.895 1679359 PK04_181112 OC(=O)CCCN1C(=O)CSC1=S 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F15 compound treatment 9301720.0 -316000.0 -0.27 9514280.0 -72200.0 -0.06 9272320.0 673862.5 0.566637264765911 0.1354 0.2144 1020755 PK04_181113 O=C(C[n+]1ccc2ccccc2c1)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F16 compound treatment 1.022632E7 608000.0 0.52 9812320.0 226000.0 0.19 8621760.0 23302.5 0.0195945981000688 0.4217 0.758 3561934 PK04_181114 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F17 mock treatment 9745800.0 128000.0 0.11 1.02054E7 619000.0 0.51 9069640.0 471182.5 0.396207776817324 0.5887 0.8949 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F18 mock treatment 9879840.0 262000.0 0.23 1.026804E7 682000.0 0.57 9163920.0 565462.5 0.475485910445668 0.7311 0.9465 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F19 compound treatment 9477120.0 -141000.0 -0.12 9881400.0 295000.0 0.24 8614040.0 15582.5 0.0131030071835349 0.0788 0.2883 3561936 PK04_181115 Brc1c2OCOc2ccc1C[n+]3ccc4ccccc4c3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F20 compound treatment 5467080.0 -4150000.0 -3.57 5715920.0 -3870000.0 -3.21 4444080.0 -4154377.5 -3.49333150814156 -5.9332 -0.999 3561937 PK04_181116 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2/C=C/c3ccncc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F21 compound treatment 9902920.0 285000.0 0.25 9718800.0 132000.0 0.11 8514520.0 -83937.5 -0.0705813358233892 0.1642 0.5911 3561939 PK04_181117 CC(C)(C)[Si](C)(C)Oc1ccc2cc[n+](Cc3ccccc3Br)cc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F22 compound treatment 8357880.0 -1260000.0 -1.08 9426080.0 -160000.0 -0.13 7839840.0 -758617.5 -0.637906019705137 -1.0713 -0.8467 1936946 PK04_181118 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F23 compound treatment 8560800.0 -1060000.0 -0.91 8568120.0 -1020000.0 -0.84 7325480.0 -1272977.5 -1.070420877714 -1.6311 -0.995 3561940 PK04_181119 COc1ccc(Br)c(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 F24 compound treatment 8246440.0 -1370000.0 -1.18 8649520.0 -937000.0 -0.78 7311520.0 -1286937.5 -1.08215955766151 -1.7551 -0.986 3561941 PK04_181120 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G01 compound treatment 7446360.0 -2170000.0 -1.87 7209240.0 -2380000.0 -1.97 7984480.0 -613977.5 -0.516281186781891 -2.5157 -0.9096 3561841 PK04_181121 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G02 compound treatment 8331120.0 -1290000.0 -1.11 8464680.0 -1120000.0 -0.93 8346440.0 -252017.5 -0.21191638779891 -1.2991 -0.8885 3561943 PK04_181122 O=C1CSC(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G03 mock treatment 9726840.0 109000.0 0.09 9337800.0 -249000.0 -0.21 8122440.0 -476017.5 -0.400273429936681 -0.2961 -0.6438 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G04 mock treatment 1.008468E7 467000.0 0.4 9653640.0 67100.0 0.06 8780760.0 182302.5 0.15329446283179 0.3526 0.8133 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G05 compound treatment 8271880.0 -1350000.0 -1.16 8892200.0 -694000.0 -0.58 7924720.0 -673737.5 -0.56653215480936 -1.3285 -0.9406 PK04_181123 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G06 compound treatment 9521560.0 -96400.0 -0.08 9002680.0 -584000.0 -0.48 8807880.0 209422.5 0.176099119004899 -0.2259 -0.4327 3561944 PK04_181124 CC(C)(C)c1ccc(cc1)N2C(SCC2=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G07 compound treatment 9979240.0 361000.0 0.31 9549800.0 -36700.0 -0.03 9418040.0 819582.5 0.68917024771375 0.5598 0.7398 PK04_181125 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G08 compound treatment 9564280.0 -53700.0 -0.05 9657480.0 71000.0 0.06 8764440.0 165982.5 0.13957130690461 0.0879 0.5549 3561945 PK04_181126 CCOC(=O)/C=C(\C)/c1ccccc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G09 compound treatment 1.025232E7 634000.0 0.55 9958440.0 372000.0 0.31 8768440.0 169982.5 0.142934825514213 0.5759 0.8953 3561841 PK04_181127 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G10 compound treatment 9841240.0 223000.0 0.19 1.00668E7 480000.0 0.4 9713600.0 1115142.5 0.93770063777732 0.8824 0.851 3561947 PK04_181128 CCOC(=O)/C=C/c1c(OC)cccc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G11 compound treatment 1.004332E7 425000.0 0.37 9724160.0 138000.0 0.11 9247360.0 648902.5 0.545648908641988 0.5923 0.8881 3561899 PK04_181129 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G12 compound treatment 1.061048E7 992000.0 0.85 1.024704E7 661000.0 0.55 9036200.0 437742.5 0.368088761241042 1.022 0.9468 3561949 PK04_181130 CCCNC(=O)Cc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G13 compound treatment 8286560.0 -1330000.0 -1.15 8817040.0 -769000.0 -0.64 7945440.0 -653017.5 -0.549109128411617 -1.3471 -0.9474 3561950 PK04_181131 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)c6cccc(Cl)c6CO)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G14 compound treatment 9248040.0 -370000.0 -0.32 1.037608E7 790000.0 0.66 8644240.0 45782.5 0.038497572686038 0.2166 0.297 3561952 PK04_181132 COc1cc(/C=C/CO)cc(OC)c1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G15 compound treatment 9829360.0 211000.0 0.18 9996520.0 410000.0 0.34 8687080.0 88622.5 0.0745208569948868 0.3444 0.8767 3561841 PK04_181133 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G16 compound treatment 1.024916E7 631000.0 0.54 1.019528E7 609000.0 0.51 9374880.0 776422.5 0.652877881916133 0.9821 0.9939 3561954 PK04_181134 COc1ccccc1/C=C/CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G17 compound treatment 9807680.0 190000.0 0.16 9300000.0 -287000.0 -0.24 8614200.0 15742.5 0.013237547927919 -0.0353 -0.1224 3561956 PK04_181135 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G18 compound treatment 9398040.0 -220000.0 -0.19 1.024292E7 656000.0 0.54 8802200.0 203742.5 0.171322922579263 0.304 0.5055 3561958 PK04_181136 O=C1CS(=O)(=O)C(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G19 mock treatment 1.019876E7 581000.0 0.5 1.048516E7 899000.0 0.75 8960440.0 361982.5 0.30438371877516 0.8947 0.944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G20 mock treatment 1.01752E7 557000.0 0.48 1.057628E7 990000.0 0.82 9139840.0 541382.5 0.455237528415857 1.0138 0.9616 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G21 compound treatment 9970000.0 352000.0 0.3 1.033768E7 751000.0 0.62 8893360.0 294902.5 0.247977511692117 0.6779 0.9211 3561959 PK04_181137 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G22 compound treatment 9038520.0 -579000.0 -0.5 9093760.0 -493000.0 -0.41 8476400.0 -122057.5 -0.102635668172906 -0.5832 -0.8932 3561961 PK04_181138 CC(C)(C)c1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G23 compound treatment 9424400.0 -194000.0 -0.17 9383080.0 -203000.0 -0.17 8524080.0 -74377.5 -0.0625425263464379 -0.2297 -0.9367 3561959 PK04_181139 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 G24 compound treatment 8103320.0 -1510000.0 -1.3 8065520.0 -1520000.0 -1.26 7921960.0 -676497.5 -0.568852982649987 -1.8095 -0.9517 2093329 PK04_181140 COC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H01 compound treatment 8161360.0 -1460000.0 -1.25 8164800.0 -1420000.0 -1.18 8136080.0 -462377.5 -0.388803831477935 -1.6292 -0.9233 3561962 PK04_181141 Brc1ccccc1C(=O)[n+]2ccc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H02 compound treatment 8916480.0 -702000.0 -0.6 9341360.0 -245000.0 -0.2 8725480.0 127022.5 0.106810635647076 -0.4043 -0.6259 3561963 PK04_181142 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H03 mock treatment 8698280.0 -920000.0 -0.79 9202400.0 -384000.0 -0.32 8438560.0 -159897.5 -0.134454554219751 -0.7186 -0.8319 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H04 mock treatment 1.00394E7 421000.0 0.36 9854080.0 268000.0 0.22 8567440.0 -31017.5 -0.0260819846183407 0.3225 0.757 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H05 compound treatment 1.019356E7 576000.0 0.5 1.001124E7 425000.0 0.35 9084160.0 485702.5 0.408417349370183 0.7252 0.9903 3561965 PK04_181143 COc1cc2CC[N+](=Cc2cc1O[Si](C)(C)C(C)(C)C)Cc3ccccc3Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H06 compound treatment 1.055268E7 935000.0 0.8 1.037496E7 788000.0 0.65 9264600.0 666142.5 0.560145673849377 1.1655 0.989 3561966 PK04_181144 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H07 compound treatment 9925080.0 307000.0 0.26 1.009768E7 511000.0 0.42 8913000.0 314542.5 0.264492388065268 0.5501 0.9731 3561968 PK04_181145 COc1cc2CC[N+](=Cc2cc1OC)C(=O)c3ccccc3Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H08 compound treatment 9964080.0 346000.0 0.3 1.039192E7 805000.0 0.67 9046560.0 448102.5 0.376800274439914 0.7753 0.9421 3561969 PK04_181146 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3C4CC5CC(C4)CC3C5)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H09 compound treatment 8627000.0 -991000.0 -0.85 7742720.0 -1840000.0 -1.53 6556840.0 -2041617.5 -1.71675461373532 -2.3667 -0.965 3561971 PK04_181147 Oc1ccc2CCN(Cc3ccccc3Br)C(C=C)c2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H10 compound treatment 9640520.0 22500.0 0.02 7340880.0 -2250000.0 -1.86 7146680.0 -1451777.5 -1.22077015956325 -1.7692 -0.7943 3561972 PK04_181148 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(O)(C4)C3)C5)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H11 compound treatment 1.068748E7 1070000.0 0.92 1.018068E7 594000.0 0.49 8920800.0 322342.5 0.271051249353994 0.9725 0.9015 3561974 PK04_181149 Brc1c[n+](Cc2ccccc2)cc3ccccc13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H12 compound treatment 1.051984E7 902000.0 0.78 1.006636E7 480000.0 0.4 8910360.0 311902.5 0.26227246578293 0.8294 0.9105 3561975 PK04_181150 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NCC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H13 compound treatment 9612360.0 -5630.0 0.0 9756600.0 170000.0 0.14 8479320.0 -119137.5 -0.100180299587896 0.0208 0.1203 3561977 PK04_181151 COc1ccc(Br)c(C[n+]2cc(Br)c3ccccc3c2)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H14 compound treatment 1.038328E7 765000.0 0.66 1.082536E7 1240000.0 1.03 1.086912E7 2270662.5 1.90935389371945 2.076 0.9161 3561978 PK04_181152 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H15 compound treatment 1.022492E7 607000.0 0.52 1.009504E7 509000.0 0.42 8498280.0 -100177.5 -0.0842372213783777 0.4965 0.7337 1003512 PK04_181153 C[n+]1ccc2ccccc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H16 compound treatment 9701880.0 83900.0 0.07 8288080.0 -1300000.0 -1.08 7600760.0 -997697.5 -0.838943527001112 -1.0646 -0.7786 3561980 PK04_181154 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H17 compound treatment 1.029156E7 674000.0 0.58 1.044728E7 861000.0 0.71 8723640.0 125182.5 0.105263417086659 0.8077 0.8725 1032420 PK04_181155 C(c1ccccc1)[n+]2ccc3ccccc3c2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H18 compound treatment 9354440.0 -264000.0 -0.23 9147280.0 -439000.0 -0.36 8241040.0 -357417.5 -0.30054510316195 -0.5148 -0.9826 3561982 PK04_181156 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H19 mock treatment 1.045884E7 841000.0 0.72 9907560.0 321000.0 0.27 8003360.0 -595097.5 -0.500405378944564 0.2827 0.3075 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H20 mock treatment 1.0695E7 1080000.0 0.93 1.062364E7 1040000.0 0.86 8555360.0 -43097.5 -0.036239810819342 1.011 0.7991 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H21 compound treatment 9410200.0 -208000.0 -0.18 9493800.0 -92700.0 -0.08 8017320.0 -581137.5 -0.48866669899705 -0.4298 -0.8171 3561984 PK04_181157 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H22 compound treatment 644880.0 -8970000.0 -7.72 649400.0 -8940000.0 -7.41 509440.0 -8089017.5 -6.80189022366371 -12.6662 -0.9986 3561985 PK04_181158 O=C1C=C[C@@H]2[C@@H]3C=C[C@H]([C@@H]2[C@]41CO4)[C@@]5(CO5)C3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H23 compound treatment 1660000.0 -7960000.0 -6.85 2560200.0 -7030000.0 -5.83 3686360.0 -4912097.5 -4.13048283835867 -9.7043 -0.9806 3561987 PK04_181159 COc1ccc(Br)c(C[n+]2ccc3c(cccc3c2)[N+](=O)[O-])c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 H24 compound treatment 7734800.0 -1880000.0 -1.62 7802400.0 -1780000.0 -1.48 7309520.0 -1288937.5 -1.08384131696631 -2.416 -0.987 3561988 PK04_181160 CC1(C)C[C@H]2C[C@H]3C(=C[C@]2(CO1)C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I01 compound treatment 6031240.0 -3590000.0 -3.09 6137520.0 -3450000.0 -2.86 5703880.0 -2894577.5 -2.43399132204708 -4.8394 -0.9953 3561956 PK04_181161 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I02 compound treatment 9166400.0 -452000.0 -0.39 8442440.0 -1140000.0 -0.95 8174360.0 -424097.5 -0.356614958384034 -0.9782 -0.9009 3561990 PK04_181162 CCCNC(=O)Cc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I03 compound treatment 7244680.0 -2370000.0 -2.04 7074040.0 -2510000.0 -2.08 7483960.0 -1114497.5 -0.937158270401522 -2.9237 -0.9539 3561991 PK04_181163 OCc1c(Cl)cccc1N2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OCC=C)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I04 compound treatment 9968720.0 351000.0 0.3 9560480.0 -26000.0 -0.02 9167320.0 568862.5 0.47834490126383 0.438 0.7738 3561993 PK04_181164 COc1ccccc1/C(=C/CO)/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I05 mock treatment 8980440.0 -638000.0 -0.55 1.02738E7 687000.0 0.57 8748040.0 149582.5 0.125780880605237 0.085 0.1061 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I06 mock treatment 1.013516E7 517000.0 0.45 1.035048E7 764000.0 0.63 8479240.0 -119217.5 -0.100247569960088 0.565 0.7235 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I07 compound treatment 9667080.0 49100.0 0.04 8662200.0 -924000.0 -0.77 8143840.0 -454617.5 -0.382278605375305 -0.639 -0.7449 3561995 PK04_181165 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I08 compound treatment 9965240.0 347000.0 0.3 9858240.0 272000.0 0.23 9486600.0 888142.5 0.746820956682347 0.7339 0.8785 3561996 PK04_181166 COc1ccccc1/C(=C/C=O)/C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I09 compound treatment 9577760.0 -40200.0 -0.03 9498840.0 -87700.0 -0.07 8900440.0 301982.5 0.253930939631114 0.0846 0.3177 3561998 PK04_181167 OCc1c(Cl)cccc1N2[C@@H](C(=O)NCc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I10 compound treatment 8434760.0 -1180000.0 -1.02 6532880.0 -3050000.0 -2.53 6051280.0 -2547177.5 -2.14186973080305 -3.2871 -0.9473 2069262 PK04_181168 COc1cc(/C=C/C=O)cc(OC)c1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I11 compound treatment 8926120.0 -692000.0 -0.6 8273640.0 -1310000.0 -1.09 7308200.0 -1290257.5 -1.08495127810748 -1.599 -0.9699 3562000 PK04_181169 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4ccccc4Cl)C(=O)N(CC=C)Cc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I12 compound treatment 9704320.0 86300.0 0.07 9637040.0 50500.0 0.04 8413160.0 -185297.5 -0.155812897390731 -0.0229 -0.1287 3562002 PK04_181170 CCOC(=O)/C=C/c1cccc(c1)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I13 compound treatment 9248080.0 -370000.0 -0.32 1.014904E7 563000.0 0.47 8894240.0 295782.5 0.248717485786229 0.2292 0.3714 3562003 PK04_181171 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N(Cc4ccccc4)[C@@H]5C(=O)N(Cc6ccccc6)CC=C[C@]35O[C@@H]2/C=C/CCC(=O)N1C)c7ccccc7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I14 compound treatment 9667000.0 49000.0 0.04 9686880.0 100000.0 0.08 8605040.0 6582.5 0.00553509031192804 0.0756 0.8087 3562005 PK04_181172 COc1cccc(OC)c1/C=C/CO 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I15 compound treatment 9339080.0 -279000.0 -0.24 9329240.0 -257000.0 -0.21 8544720.0 -53737.5 -0.0451867703208861 -0.2879 -0.8876 3562007 PK04_181173 CCCCNC(=O)[C@@H]1N(C2CCCCC2)C(=O)[C@H]3[C@@H]([C@H]4O[C@@]13C=C4)C(=O)OCC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I16 compound treatment 9590400.0 -27600.0 -0.02 8933680.0 -653000.0 -0.54 8694560.0 96102.5 0.0808106367948445 -0.2797 -0.5104 3562009 PK04_181174 Clc1cccc(c1)N2C(SCC2=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I17 compound treatment 8963280.0 -655000.0 -0.56 8712560.0 -874000.0 -0.72 7823480.0 -774977.5 -0.651662810818414 -1.1201 -0.9948 3561995 PK04_181175 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I18 compound treatment 9954080.0 336000.0 0.29 9824600.0 238000.0 0.2 8283800.0 -314657.5 -0.264589089225294 0.1283 0.2922 3065130 PK04_181176 Clc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I19 compound treatment 9750080.0 132000.0 0.11 1.045304E7 867000.0 0.72 8904320.0 305862.5 0.257193552682429 0.6292 0.8151 3562010 PK04_181177 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I20 compound treatment 9264320.0 -354000.0 -0.3 9781160.0 195000.0 0.16 8008400.0 -590057.5 -0.496167345496465 -0.369 -0.6108 3562012 PK04_181178 OC/C=C/c1cccc(c1)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I21 mock treatment 9657800.0 39800.0 0.03 9585640.0 -860.0 0.0 8156520.0 -441937.5 -0.371616251382863 -0.1952 -0.523 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I22 mock treatment 8959760.0 -658000.0 -0.57 9032600.0 -554000.0 -0.46 7981520.0 -616937.5 -0.518770190552997 -0.8919 -0.9964 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I23 compound treatment 9166680.0 -451000.0 -0.39 9669200.0 82700.0 0.07 7670480.0 -927977.5 -0.780317397635731 -0.6352 -0.7264 3562014 PK04_181179 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N([C@@H]4C(=O)N(Cc5ccccc5)CC=C[C@]34O[C@@H]2/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 I24 compound treatment 8621640.0 -996000.0 -0.86 8774600.0 -812000.0 -0.67 7227240.0 -1371217.5 -1.15302889476585 -1.5496 -0.9765 3215604 PK04_181180 O=C/1N(C(c2ccccc2)S(=O)(=O)\C1=C/c3ccc4ccccc4c3)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J01 compound treatment 7606640.0 -2010000.0 -1.73 8441280.0 -1150000.0 -0.95 7492800.0 -1105657.5 -0.929724894274299 -2.0847 -0.9552 3562016 PK04_181181 COc1ccc(Br)c(C[n+]2ccccc2C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J02 compound treatment 7076160.0 -2540000.0 -2.19 7520200.0 -2070000.0 -1.71 6978040.0 -1620417.5 -1.36257610414412 -3.0394 -0.9819 3562017 PK04_181182 OCCCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J03 compound treatment 8703200.0 -915000.0 -0.79 9189560.0 -397000.0 -0.33 7695280.0 -903177.5 -0.759463582256192 -1.0831 -0.9481 3562019 PK04_181183 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J04 compound treatment 8054120.0 -1560000.0 -1.35 7999120.0 -1590000.0 -1.32 8357520.0 -240937.5 -0.202599441250309 -1.6543 -0.8735 3562020 PK04_181184 OCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J05 mock treatment 9312280.0 -306000.0 -0.26 9669120.0 82600.0 0.07 8719880.0 121422.5 0.102101709593632 -0.0534 -0.1838 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J06 mock treatment 9699880.0 81900.0 0.07 1.007884E7 492000.0 0.41 9444640.0 846182.5 0.71153764646761 0.6873 0.8347 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J07 compound treatment 9941240.0 323000.0 0.28 9330480.0 -256000.0 -0.21 8458840.0 -139617.5 -0.117401514869064 -0.0298 -0.0807 3562022 PK04_181185 Cc1[n+](Cc2ccccc2)ccc3ccccc13 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J08 compound treatment 6901000.0 -2720000.0 -2.34 5278200.0 -4310000.0 -3.57 4688880.0 -3909577.5 -3.28748416923385 -5.3116 -0.9855 3562023 PK04_181186 BrC1=C[C@@]2(Br)[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J09 compound treatment 9748720.0 131000.0 0.11 9143760.0 -443000.0 -0.37 7585600.0 -1012857.5 -0.851691262531508 -0.6388 -0.6837 3562025 PK04_181187 COc1ccc(Br)c(C[n+]2cccc3cc(OC)ccc23)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J10 compound treatment 7799160.0 -1820000.0 -1.57 5590760.0 -4000000.0 -3.31 5400080.0 -3198377.5 -2.68945056044643 -4.3703 -0.9612 3562026 PK04_181188 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@]2(Br)C(=O)[C@@]43CO4)Br 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J11 compound treatment 1.01258E7 508000.0 0.44 9922080.0 336000.0 0.28 8628440.0 29982.5 0.0252116741781059 0.4276 0.8242 3562028 PK04_181189 COc1ccc(Br)c(C[N+]2=C(C)CCC2)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J12 compound treatment 7803800.0 -1810000.0 -1.56 8105040.0 -1480000.0 -1.23 6891080.0 -1707377.5 -1.43569899871689 -2.4399 -0.9953 3562029 PK04_181190 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J13 compound treatment 8161640.0 -1460000.0 -1.25 8288440.0 -1300000.0 -1.08 7315560.0 -1282897.5 -1.07876240386581 -1.9682 -0.9974 3562031 PK04_181191 COc1ccc(Br)c(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J14 compound treatment 9772120.0 154000.0 0.13 9611920.0 25400.0 0.02 8170000.0 -428457.5 -0.360281193668501 -0.1192 -0.3101 3562032 PK04_181192 COc1ccc(CCNC(=O)[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J15 compound treatment 9306720.0 -311000.0 -0.27 9415080.0 -171000.0 -0.14 7796960.0 -801497.5 -0.673962939200082 -0.6259 -0.8469 3562033 PK04_181193 COC(CN(Cc1cccc(OC)c1)S(=O)(=O)c2ccc(C)cc2)OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J16 compound treatment 8026800.0 -1590000.0 -1.37 7727720.0 -1860000.0 -1.54 7147640.0 -1450817.5 -1.21996291509695 -2.3853 -0.9955 3562034 PK04_181194 COc1ccc(CCN2C(=O)C3(CC(=O)N(Cc4ccccc4)C3c5ccccc5)c6cc(ccc26)[N+](=O)[O-])cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J17 compound treatment 9640880.0 22900.0 0.02 9411920.0 -175000.0 -0.14 8750520.0 152062.5 0.127866262143191 0.0016 0.0081 3562035 PK04_181195 COc1ccc(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J18 compound treatment 9961840.0 344000.0 0.3 9654880.0 68400.0 0.06 8149640.0 -448817.5 -0.37740150339138 -0.0143 -0.0296 3562036 PK04_181196 C[C@@]1(CCc2ccccc2)C[C@@H](C[Si](C)(C)C(c3ccccc3)c4ccccc4)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J19 compound treatment 8199640.0 -1420000.0 -1.22 8025800.0 -1560000.0 -1.29 7564080.0 -1034377.5 -0.869786992651172 -1.9544 -0.9868 3562038 PK04_181197 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J20 compound treatment 9661600.0 43600.0 0.04 1.025568E7 669000.0 0.56 8323560.0 -274897.5 -0.231155714245839 0.2087 0.3464 3562039 PK04_181198 CCCCCCC1C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J21 mock treatment 9113360.0 -505000.0 -0.43 9686760.0 100000.0 0.08 8537640.0 -60817.5 -0.0511401982598835 -0.2323 -0.5217 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J22 mock treatment 9658840.0 40800.0 0.04 1.020612E7 620000.0 0.51 8093240.0 -505217.5 -0.424827115786784 0.0718 0.1075 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J23 compound treatment 7540920.0 -2080000.0 -1.79 8182040.0 -1400000.0 -1.17 7231280.0 -1367177.5 -1.14963174097015 -2.3685 -0.9772 3562041 PK04_181199 COc1cc2CCN(CC=C)C(C#Cc3ccccc3)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 J24 compound treatment 7762080.0 -1860000.0 -1.6 8597360.0 -989000.0 -0.82 6692040.0 -1906417.5 -1.60306768473074 -2.3215 -0.9644 3562042 PK04_181200 Cc1ccc(cc1)C2C[C@]3(CC[C@@H](CC3)C(C)(C)C)OO2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K01 compound treatment 6925560.0 -2690000.0 -2.32 8202240.0 -1380000.0 -1.15 7582560.0 -1015897.5 -0.854247536674806 -2.494 -0.9157 3562010 PK04_181201 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K02 compound treatment 9045000.0 -573000.0 -0.49 8177200.0 -1410000.0 -1.17 7966360.0 -632097.5 -0.531517926083393 -1.2666 -0.9207 3215602 PK04_181202 Cc1c(NC(=O)/C(=C/c2ccc3ccccc3c2)/C#N)c(=O)n(c4ccccc4)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K03 compound treatment 7832120.0 -1790000.0 -1.54 7976800.0 -1610000.0 -1.34 7994240.0 -604217.5 -0.508074201374459 -1.9517 -0.93 3562044 PK04_181203 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K04 compound treatment 8764560.0 -853000.0 -0.73 8291080.0 -1300000.0 -1.07 8009960.0 -588497.5 -0.494855573238719 -1.3302 -0.9552 3562046 PK04_181204 COc1cccc(OC)c1/C=C/C=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K05 compound treatment 8912880.0 -705000.0 -0.61 8549800.0 -1040000.0 -0.86 7724560.0 -873897.5 -0.734842626033898 -1.2712 -0.9902 2065615 PK04_181205 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K06 compound treatment 9656120.0 38100.0 0.03 8555480.0 -1030000.0 -0.86 8547760.0 -50697.5 -0.0426304961775878 -0.4995 -0.5828 3562048 PK04_181206 Clc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K07 mock treatment 9641960.0 24000.0 0.02 8848600.0 -738000.0 -0.61 8247440.0 -351017.5 -0.295163473386586 -0.5119 -0.7529 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K08 mock treatment 1.025176E7 634000.0 0.55 9472200.0 -114000.0 -0.09 9046320.0 447862.5 0.376598463323338 0.4776 0.7133 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K09 compound treatment 8161760.0 -1460000.0 -1.25 8359200.0 -1230000.0 -1.02 7722520.0 -875937.5 -0.736558020524795 -1.7367 -0.9785 3562049 PK04_181207 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K10 compound treatment 9459920.0 -158000.0 -0.14 9592600.0 6100.0 0.01 8270520.0 -327937.5 -0.275755971009176 -0.2348 -0.7636 3562051 PK04_181208 Clc1cccc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K11 compound treatment 8377200.0 -1240000.0 -1.07 8839000.0 -748000.0 -0.62 7626160.0 -972297.5 -0.817585183830133 -1.4466 -0.9768 3562052 PK04_181209 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K12 compound treatment 1.059188E7 974000.0 0.84 1.03482E7 762000.0 0.63 8938240.0 339782.5 0.285716190491863 1.0137 0.9318 3562054 PK04_181210 O=C1CSCN1c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K13 compound treatment 9422720.0 -195000.0 -0.17 8973920.0 -613000.0 -0.51 7764320.0 -834137.5 -0.701409251054443 -0.7954 -0.9015 3562052 PK04_181211 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K14 compound treatment 1.013888E7 521000.0 0.45 1.043672E7 850000.0 0.71 9293800.0 695342.5 0.584699359699479 1.0036 0.984 1951450 PK04_181212 Cc1c(N2C(SCC2=O)c3ccccc3)c(=O)n(c4ccccc4)n1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K15 mock treatment 9549600.0 -68400.0 -0.06 1.047972E7 893000.0 0.74 8134440.0 -464017.5 -0.390182874107872 0.1686 0.2008 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K16 mock treatment 9478480.0 -140000.0 -0.12 9471120.0 -115000.0 -0.1 8702920.0 104462.5 0.0878403906889149 -0.0739 -0.4176 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K17 compound treatment 9208800.0 -409000.0 -0.35 9107040.0 -479000.0 -0.4 7971440.0 -627017.5 -0.527246257449197 -0.7374 -0.9852 3562052 PK04_181213 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K18 compound treatment 1.015588E7 538000.0 0.46 9830000.0 244000.0 0.2 8703440.0 104982.5 0.0882776481081633 0.4349 0.8481 3562055 PK04_181214 CN1C(SCC1=O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K19 compound treatment 9015640.0 -602000.0 -0.52 8214000.0 -1370000.0 -1.14 6973840.0 -1624617.5 -1.3661077986842 -1.7454 -0.9422 3562056 PK04_181215 COCOc1ccc2cc(Br)ccc2c1c3c(OCOC)ccc4cc(Br)ccc34 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K20 compound treatment 9430040.0 -188000.0 -0.16 9537600.0 -48900.0 -0.04 8084880.0 -513577.5 -0.431856869680854 -0.3661 -0.7909 3562057 PK04_181216 O=C1CS(=O)(=O)CN1c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K21 compound treatment 9050280.0 -568000.0 -0.49 9549600.0 -36900.0 -0.03 7798840.0 -799617.5 -0.672382085453569 -0.688 -0.8272 3220192 PK04_181217 CC(CO)N1C2C(=O)N(Cc3ccccc3)CC=CC42OC5C=CCOC(=O)C5C4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K22 compound treatment 9228840.0 -389000.0 -0.33 9269080.0 -317000.0 -0.26 8269040.0 -329417.5 -0.277000472894729 -0.5053 -0.9944 3562058 PK04_181218 CN1C(c2ccccc2)S(=O)(=O)CC1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K23 mock treatment 9570600.0 -47400.0 -0.04 8785560.0 -801000.0 -0.66 7792000.0 -806457.5 -0.67813370227599 -0.7987 -0.8405 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 K24 mock treatment 8522760.0 -1100000.0 -0.94 8473400.0 -1110000.0 -0.92 7626840.0 -971617.5 -0.817013385666501 -1.549 -0.9981 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L01 compound treatment 8375360.0 -1240000.0 -1.07 8807960.0 -779000.0 -0.65 7546640.0 -1051817.5 -0.884451933789042 -1.501 -0.9806 3562059 PK04_181219 COc1cc2CC[N+](=Cc2cc1OC)Cc3ccc(Br)cc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L02 compound treatment 8502640.0 -1120000.0 -0.96 8972840.0 -614000.0 -0.51 8227040.0 -371417.5 -0.312317418295561 -1.0284 -0.9097 3562060 PK04_181220 CCOC(=O)CCC1(C)C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L03 compound treatment 8725760.0 -892000.0 -0.77 8515000.0 -1070000.0 -0.89 7785480.0 -812977.5 -0.683616237609643 -1.3512 -0.9942 3562062 PK04_181221 Cc1cc2ccccc2c[n+]1CCCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L04 compound treatment 811360.0 -8810000.0 -7.58 628920.0 -8960000.0 -7.43 743040.0 -7855417.5 -6.60546073686289 -12.4799 -0.9982 3562063 PK04_181222 CC1(CCc2ccccc2)CC(CO)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L05 compound treatment 9037040.0 -581000.0 -0.5 8632600.0 -954000.0 -0.79 7484680.0 -1113777.5 -0.936552837051793 -1.2863 -0.9714 3562064 PK04_181223 COc1ccc(Br)c(C[n+]2cc3ccccc3cc2C)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L06 compound treatment 6942000.0 -2680000.0 -2.3 7115280.0 -2470000.0 -2.05 6195440.0 -2403017.5 -2.02064852011296 -3.6799 -0.9982 3562065 PK04_181224 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CC(C)(C)CO)OO2)CC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L07 mock treatment 9492480.0 -126000.0 -0.11 9400240.0 -186000.0 -0.15 8552000.0 -46457.5 -0.0390651664514085 -0.1741 -0.9044 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L08 mock treatment 9918720.0 301000.0 0.26 9885360.0 299000.0 0.25 8815720.0 217262.5 0.182691615479721 0.398 0.9895 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L09 compound treatment 1.077168E7 1150000.0 0.99 9114680.0 -472000.0 -0.39 8623200.0 24742.5 0.0208054647995259 0.3593 0.3366 3562067 PK04_181225 CC1=[N+](C)C2C3CC=CC3C1c4ccccc24 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L10 compound treatment 2695280.0 -6920000.0 -5.96 1592080.0 -7990000.0 -6.63 1466000.0 -7132457.5 -5.99753838336323 -10.7315 -0.9988 3562068 PK04_181226 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L11 compound treatment 1.032048E7 702000.0 0.6 9312360.0 -274000.0 -0.23 8549400.0 -49057.5 -0.0412514535476505 0.1939 0.2996 1006359 PK04_181227 Cc1cccc[n+]1C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L12 compound treatment 8754800.0 -863000.0 -0.74 9244760.0 -342000.0 -0.28 7532160.0 -1066297.5 -0.896627871155805 -1.1103 -0.9264 3562070 PK04_181228 CC1(CCOCc2ccccc2)CC(C)(CCc3ccccc3)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L13 compound treatment 1.076736E7 1150000.0 0.99 9828520.0 242000.0 0.2 9194320.0 595862.5 0.501048651878651 0.9763 0.8664 3562071 PK04_181229 C[n+]1cc2ccccc2cc1C#N 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L14 compound treatment 5185560.0 -4430000.0 -3.81 5137400.0 -4450000.0 -3.69 4468760.0 -4129697.5 -3.47257859832031 -6.3382 -0.9993 3562072 PK04_181230 COc1ccc(CN/2C(C3CC3)c4ccccc4C\C2=N\P(=O)(Oc5ccccc5)Oc6ccccc6)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L15 mock treatment 1.00658E7 448000.0 0.39 1.038376E7 797000.0 0.66 8686040.0 87582.5 0.07364634215639 0.6469 0.8412 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L16 mock treatment 9549000.0 -69000.0 -0.06 1.033364E7 747000.0 0.62 9109160.0 510702.5 0.429439340680202 0.5715 0.7556 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L17 compound treatment 9297560.0 -320000.0 -0.28 9526680.0 -59800.0 -0.05 8191280.0 -407177.5 -0.342387274665413 -0.3855 -0.8714 3562074 PK04_181231 CCCCOC1CC2[N+](=C(C)C1c3ccccc23)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L18 compound treatment 1.01456E7 528000.0 0.45 9695000.0 109000.0 0.09 8802440.0 203982.5 0.171524733695839 0.4132 0.8369 3562075 PK04_181232 CCCCCCC1C[C@]2(CCC[C@@H](C)C2)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L19 compound treatment 9624520.0 6530.0 0.01 9648000.0 61500.0 0.05 8406240.0 -192217.5 -0.161631784585344 -0.0606 -0.3575 3188663 PK04_181233 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L20 compound treatment 2289640.0 -7330000.0 -6.31 1879640.0 -7710000.0 -6.39 1646440.0 -6952017.5 -5.84581005888404 -10.7077 -0.9992 3562077 PK04_181234 CC1(CCO)CC(C)(CCc2ccccc2)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L21 compound treatment 8149280.0 -1470000.0 -1.26 7839560.0 -1750000.0 -1.45 7317720.0 -1280737.5 -1.07694610381663 -2.1883 -0.9928 3070955 PK04_181235 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L22 compound treatment 8368840.0 -1250000.0 -1.08 8319480.0 -1270000.0 -1.05 7560120.0 -1038337.5 -0.873116876074679 -1.7316 -0.996 3562078 PK04_181236 COC(=O)CC1(C)CC(C)(CCc2ccccc2)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L23 mock treatment 8547160.0 -1070000.0 -0.92 8598120.0 -988000.0 -0.82 7963160.0 -635297.5 -0.534208740971075 -1.3139 -0.9774 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 L24 mock treatment 7913680.0 -1700000.0 -1.47 7881320.0 -1710000.0 -1.41 7410200.0 -1188257.5 -0.999181553562602 -2.2404 -0.9872 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M01 compound treatment 7935760.0 -1680000.0 -1.45 6989760.0 -2600000.0 -2.15 6535120.0 -2063337.5 -1.73501851978546 -3.0813 -0.987 3562079 PK04_181237 CC(C)(C)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C\COC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M02 compound treatment 1943320.0 -7670000.0 -6.61 2108400.0 -7480000.0 -6.2 1921200.0 -6677257.5 -5.6147699655904 -10.6368 -0.9978 3562081 PK04_181238 Clc1ccccc1/C=C/C=C\2/C(=O)N(CS2(=O)=O)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M03 compound treatment 7669640.0 -1950000.0 -1.68 6965520.0 -2620000.0 -2.17 6535480.0 -2062977.5 -1.7347158031106 -3.225 -0.993 3562049 PK04_181239 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M04 compound treatment 2172080.0 -7450000.0 -6.41 2450600.0 -7140000.0 -5.92 2452800.0 -6145657.5 -5.16775834237416 -10.1012 -0.9962 3562083 PK04_181240 CN1C(c2ccccc2)S(=O)(=O)/C(=C\C=C\c3ccccc3Cl)/C1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M05 compound treatment 8060360.0 -1560000.0 -1.34 8267320.0 -1320000.0 -1.09 7183120.0 -1415337.5 -1.19012850502977 -2.0929 -0.9965 3562085 PK04_181241 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M06 compound treatment 9630800.0 12800.0 0.01 9045040.0 -541000.0 -0.45 8030160.0 -568297.5 -0.477869804260224 -0.5289 -0.8063 1053847 PK04_181242 O=C1CSC(N1c2ccccc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M07 compound treatment 9496400.0 -122000.0 -0.1 9184560.0 -402000.0 -0.33 7826800.0 -771657.5 -0.648871090372444 -0.6276 -0.8515 3562085 PK04_181243 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M08 compound treatment 8901480.0 -717000.0 -0.62 8830720.0 -756000.0 -0.63 8355520.0 -242937.5 -0.204281200555111 -0.836 -0.9259 3562087 PK04_181244 COc1ccccc1/C=C/C=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M09 mock treatment 9130880.0 -487000.0 -0.42 9282520.0 -304000.0 -0.25 8336120.0 -262337.5 -0.220594265811686 -0.515 -0.9596 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M10 mock treatment 9451360.0 -167000.0 -0.14 9448200.0 -138000.0 -0.11 8498880.0 -99577.5 -0.0837326935869372 -0.1974 -0.9779 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M11 compound treatment 8411080.0 -1210000.0 -1.04 8504880.0 -1080000.0 -0.9 7696480.0 -901977.5 -0.758454526673311 -1.5556 -0.992 3562085 PK04_181245 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M12 compound treatment 9852880.0 235000.0 0.2 9539840.0 -46700.0 -0.04 8832840.0 234382.5 0.197087475128822 0.2082 0.7304 3562088 PK04_181246 O=C1CS(=O)(=O)C(N1c2ccccc2)c3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M13 mock treatment 1.007084E7 453000.0 0.39 1.017908E7 593000.0 0.49 8329080.0 -269377.5 -0.226514058564587 0.3781 0.5668 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M14 mock treatment 9668280.0 50300.0 0.04 9614880.0 28400.0 0.02 8638960.0 40502.5 0.034057728121362 0.0582 0.9724 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M15 compound treatment 9013720.0 -604000.0 -0.52 8697040.0 -889000.0 -0.74 7408720.0 -1189737.5 -1.00042605544816 -1.3039 -0.9676 3562089 PK04_181247 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M16 compound treatment 5412440.0 -4210000.0 -3.62 7547960.0 -2040000.0 -1.69 2442640.0 -6155817.5 -5.17630167964255 -6.0546 -0.926 2118235 PK04_181248 [O-][N+](=O)c1cccc(/C=C/C=O)c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M17 compound treatment 8792880.0 -825000.0 -0.71 8902840.0 -684000.0 -0.57 7348080.0 -1250377.5 -1.05141699756974 -1.3445 -0.9674 3562089 PK04_181249 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M18 compound treatment 8128520.0 -1490000.0 -1.28 7978960.0 -1610000.0 -1.33 6609960.0 -1988497.5 -1.67208708659979 -2.4754 -0.9927 3562090 PK04_181250 CC(C)Cc1ccc(/C=C/C=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M19 compound treatment 8955040.0 -663000.0 -0.57 9097400.0 -489000.0 -0.41 7879640.0 -718817.5 -0.604439009539587 -0.9126 -0.9867 3561852 PK04_181251 CCOC(=O)C1C2OC3(C=C2)C(N(C(=O)C13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M20 compound treatment 5834240.0 -3780000.0 -3.26 5624800.0 -3960000.0 -3.29 5522640.0 -3075817.5 -2.58639235024819 -5.2708 -0.9944 3215597 PK04_181252 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4cc(C)cc(C)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M21 compound treatment 8825920.0 -792000.0 -0.68 8971280.0 -615000.0 -0.51 7552800.0 -1045657.5 -0.879272115130253 -1.1959 -0.977 3562092 PK04_181253 O=C1C2C3C(OC42C=CCN(Cc5ccccc5)C(=O)C4N1C6CCCCC6)C=CCOC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M22 compound treatment 8747680.0 -870000.0 -0.75 8840920.0 -746000.0 -0.62 7811720.0 -786737.5 -0.661551555530647 -1.1715 -0.9968 3562093 PK04_181254 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M23 compound treatment 6015480.0 -3600000.0 -3.1 7087320.0 -2500000.0 -2.07 5556920.0 -3041537.5 -2.55756699576389 -4.4637 -0.987 3562094 PK04_181255 O=C1C2C3C4OC2(C=C4)C(N1C5CCCCC5)C(=O)N(Cc6ccccc6)CCCCOC3=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 M24 compound treatment 7764400.0 -1850000.0 -1.6 8075440.0 -1510000.0 -1.25 7515120.0 -1083337.5 -0.910956460432714 -2.1707 -0.976 3562095 PK04_181256 Cc1cc(C)cc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N01 compound treatment 6568920.0 -3050000.0 -2.62 7950320.0 -1640000.0 -1.36 6648040.0 -1950417.5 -1.64006638943637 -3.2456 -0.9605 3188533 PK04_181257 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N02 compound treatment 8394240.0 -1220000.0 -1.05 8317440.0 -1270000.0 -1.05 7750520.0 -847937.5 -0.713013390257574 -1.6275 -0.9858 3562096 PK04_181258 CC1(CCc2ccccc2)CC(C)(CC(=O)O)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N03 compound treatment 8110720.0 -1510000.0 -1.3 8341760.0 -1240000.0 -1.03 7103080.0 -1495377.5 -1.25743251240793 -2.0711 -0.9953 3562097 PK04_181259 C=C/C=C/[C@H]1[C@@H]2[C@H](Cc3ccccc3)OC(=O)[C@H](Cc4ccccc4)N2CC1=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N04 compound treatment 7115560.0 -2500000.0 -2.15 8670720.0 -916000.0 -0.76 8747200.0 148742.5 0.125074541697221 -1.6098 -0.7039 3562099 PK04_181260 CC1(CCOCc2ccccc2)CC(C)(COCc3ccccc3)OO1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N05 compound treatment 9091640.0 -526000.0 -0.45 8295520.0 -1290000.0 -1.07 8008160.0 -590297.5 -0.496369156613041 -1.1664 -0.9226 3562100 PK04_181261 Cn1c(=O)n2[C@H]3[C@@H]4[C@H](Cc5ccccc5)OC(=O)[C@H](Cc6ccccc6)N4CC3=C[C@@H](C7CC7)n2c1=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N06 compound treatment 9075080.0 -543000.0 -0.47 8673840.0 -913000.0 -0.76 8671360.0 72902.5 0.0613022288591468 -0.6715 -0.753 3562102 PK04_181262 C[C@@H]1CCC[C@]2(CC(C)(CCOCc3ccccc3)OO2)C1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N07 compound treatment 9066000.0 -552000.0 -0.48 8733720.0 -853000.0 -0.71 7925720.0 -672737.5 -0.56569127515696 -1.0093 -0.9868 3562104 PK04_181263 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3[C@H]1Cc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N08 compound treatment 9741880.0 124000.0 0.11 9519720.0 -66800.0 -0.06 8554200.0 -44257.5 -0.0372152312161269 0.0081 0.0643 3562106 PK04_181264 CC1(C)O[C@]2(C)CC[C@@H]1OO2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N09 mock treatment 9482280.0 -136000.0 -0.12 9144240.0 -442000.0 -0.37 8347360.0 -251097.5 -0.211142778518701 -0.4012 -0.9135 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N10 mock treatment 9532600.0 -85400.0 -0.07 9054600.0 -532000.0 -0.44 8498280.0 -100177.5 -0.0842372213783777 -0.3458 -0.7597 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N11 compound treatment 8824000.0 -794000.0 -0.68 8720640.0 -866000.0 -0.72 7471800.0 -1126657.5 -0.947383366974715 -1.3562 -0.989 3188666 PK04_181265 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N12 compound treatment 1.004448E7 426000.0 0.37 9627280.0 40800.0 0.03 8449480.0 -148977.5 -0.125272148415535 0.1591 0.4087 3562108 PK04_181266 CC[C@]1(CC[C@@H]2OO1)OC2(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N13 mock treatment 9718920.0 101000.0 0.09 1.02186E7 632000.0 0.52 8410040.0 -188417.5 -0.158436441906221 0.2614 0.4713 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N14 mock treatment 9549520.0 -68500.0 -0.06 9294640.0 -292000.0 -0.24 9011440.0 412982.5 0.347268581047599 0.0267 0.0624 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N15 compound treatment 8187320.0 -1430000.0 -1.23 8812560.0 -774000.0 -0.64 7481520.0 -1116937.5 -0.93921001675338 -1.6238 -0.9686 3188536 PK04_181267 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N16 compound treatment 9895840.0 278000.0 0.24 9373360.0 -213000.0 -0.18 8366880.0 -231577.5 -0.194728807703838 -0.0765 -0.2151 3562110 PK04_181268 CCC[C@]1(CC[C@@H]2OO1)OC2(C)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N17 compound treatment 9066960.0 -551000.0 -0.47 8771320.0 -815000.0 -0.68 8113200.0 -485257.5 -0.408043157924864 -0.8998 -0.9767 3188535 PK04_181269 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N18 compound treatment 8516280.0 -1100000.0 -0.95 8711640.0 -875000.0 -0.73 7610320.0 -988137.5 -0.830904717524161 -1.4462 -0.9941 3562112 PK04_181270 CC1(C)O[C@]2(CCc3ccccc3)CC[C@@H]1OO2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N19 compound treatment 8705320.0 -913000.0 -0.79 8781480.0 -805000.0 -0.67 7494320.0 -1104137.5 -0.92844675720265 -1.3751 -0.9911 3070940 PK04_181271 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N20 compound treatment 4559880.0 -5060000.0 -4.35 5285040.0 -4300000.0 -3.57 3788000.0 -4810457.5 -4.04501583048865 -6.9089 -0.9967 3562114 PK04_181272 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N21 compound treatment 8517960.0 -1100000.0 -0.95 8654160.0 -932000.0 -0.77 7940120.0 -658337.5 -0.553582608162389 -1.3128 -0.9782 3188534 PK04_181273 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N22 compound treatment 8042560.0 -1580000.0 -1.36 8344600.0 -1240000.0 -1.03 7925440.0 -673017.5 -0.565926721459632 -1.7044 -0.9498 3562115 PK04_181274 CC(C)(C)[C@H]1CC[C@]2(CC(C[Si](C)(C)C)OO2)CC1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N23 compound treatment 6721160.0 -2900000.0 -2.49 6453600.0 -3130000.0 -2.6 6518760.0 -2079697.5 -1.74877531089874 -3.9496 -0.9865 3562117 PK04_181275 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@H](C4CC4)n5n([C@@H]3[C@H]2[C@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 N24 compound treatment 7681080.0 -1940000.0 -1.67 7963080.0 -1620000.0 -1.35 7174160.0 -1424297.5 -1.19766278671528 -2.4314 -0.9904 1004341 PK04_181276 c1ccc2cnccc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O01 compound treatment 6578120.0 -3040000.0 -2.62 8970680.0 -616000.0 -0.51 7144600.0 -1453857.5 -1.22251918924025 -2.5113 -0.8563 3562118 PK04_181277 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)c4cccc(Cl)c4CO)C(=O)NCc5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O02 compound treatment 5871440.0 -3750000.0 -3.22 5759840.0 -3830000.0 -3.17 5577200.0 -3021257.5 -2.5405139564132 -5.1612 -0.9946 3562120 PK04_181278 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O03 compound treatment 7861240.0 -1760000.0 -1.51 7586880.0 -2000000.0 -1.66 7262400.0 -1336057.5 -1.12346356618744 -2.4793 -0.9878 3562122 PK04_181279 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O04 compound treatment 3938800.0 -5680000.0 -4.89 3450480.0 -6140000.0 -5.09 3233880.0 -5364577.5 -4.51096406347697 -8.3652 -0.9988 3562124 PK04_181280 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O05 compound treatment 8502880.0 -1120000.0 -0.96 8765920.0 -821000.0 -0.68 7726800.0 -871657.5 -0.73295905561252 -1.3703 -0.9885 3562122 PK04_181281 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O06 compound treatment 5738120.0 -3880000.0 -3.34 5519240.0 -4070000.0 -3.37 5741480.0 -2856977.5 -2.40237424711681 -5.2629 -0.9892 3562126 PK04_181282 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4cc(C)cc(C)c4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O07 compound treatment 4229280.0 -5390000.0 -4.64 4375600.0 -5210000.0 -4.32 3600040.0 -4998417.5 -4.2030675699539 -7.6 -0.9991 3562128 PK04_181283 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O08 compound treatment 3079760.0 -6540000.0 -5.63 3046360.0 -6540000.0 -5.43 2486080.0 -6112377.5 -5.13977386754226 -9.3487 -0.9993 3215600 PK04_181284 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O09 compound treatment 3890800.0 -5730000.0 -4.93 4558440.0 -5030000.0 -4.17 3335120.0 -5263337.5 -4.42583340746791 -7.8092 -0.9976 3562128 PK04_181285 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O10 compound treatment 9627960.0 9970.0 0.01 9660080.0 73600.0 0.06 8770640.0 172182.5 0.144784760749495 0.1238 0.7866 3562130 PK04_181286 OCCSCC(O)CC(O)c1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O11 mock treatment 9253120.0 -365000.0 -0.31 9484200.0 -102000.0 -0.08 8771640.0 173182.5 0.145625640401896 -0.1462 -0.4103 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O12 mock treatment 9560640.0 -57400.0 -0.05 9853840.0 267000.0 0.22 9440200.0 841742.5 0.707804140810951 0.5082 0.6836 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O13 compound treatment 8688680.0 -929000.0 -0.8 9708720.0 122000.0 0.1 8468760.0 -129697.5 -0.109059988717248 -0.4662 -0.573 3561848 PK04_181287 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O14 compound treatment 9985040.0 367000.0 0.32 1.025116E7 665000.0 0.55 8991360.0 392902.5 0.330383717627392 0.6915 0.9654 3562131 PK04_181288 OC(CSc1ccncc1)CC(O)c2ccccc2 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O15 compound treatment 9189440.0 -429000.0 -0.37 9659800.0 73300.0 0.06 8826920.0 228462.5 0.19210946758661 -0.0669 -0.1592 3562132 PK04_181289 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O16 compound treatment 9057960.0 -560000.0 -0.48 9494840.0 -91700.0 -0.08 8785760.0 187302.5 0.157498861093794 -0.2312 -0.451 3562134 PK04_181290 COC(=O)CCCCCCC(=O)Nc1ccc(C=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O17 compound treatment 9391760.0 -226000.0 -0.19 9642920.0 56400.0 0.05 8236360.0 -362097.5 -0.304480419935186 -0.2612 -0.7167 3562132 PK04_181291 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O18 compound treatment 9484960.0 -133000.0 -0.11 8678320.0 -908000.0 -0.75 8274360.0 -324097.5 -0.272526993143957 -0.6584 -0.8136 3562135 PK04_181292 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccccn3)CC(O2)c4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O19 compound treatment 6786280.0 -2830000.0 -2.44 7174200.0 -2410000.0 -2.0 5944760.0 -2653697.5 -2.23144023137678 -3.8508 -0.9968 3561921 PK04_181293 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O20 compound treatment 8460200.0 -1160000.0 -1.0 8602280.0 -984000.0 -0.82 6881600.0 -1716857.5 -1.44367053782165 -1.8802 -0.9717 3562136 PK04_181294 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc4ccccc4s3)CC(O2)c5ccccc5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O21 compound treatment 9107840.0 -510000.0 -0.44 9066080.0 -520000.0 -0.43 7642480.0 -955977.5 -0.803862027902952 -0.9669 -0.9548 3561921 PK04_181295 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O22 compound treatment 8555400.0 -1060000.0 -0.91 8325880.0 -1260000.0 -1.05 7957360.0 -641097.5 -0.539085842955 -1.443 -0.9684 3562137 PK04_181296 OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O23 compound treatment 8522280.0 -1100000.0 -0.94 8398880.0 -1190000.0 -0.99 8262360.0 -336097.5 -0.282617548972766 -1.2764 -0.9165 3561921 PK04_181297 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 O24 compound treatment 6985400.0 -2630000.0 -2.27 7445680.0 -2140000.0 -1.78 7031720.0 -1566737.5 -1.31743768440324 -3.0941 -0.9773 3562138 PK04_181298 CC(C)(C)OC(=O)OC(CC=C)c1ccccc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P01 compound treatment 5693240.0 -3920000.0 -3.38 5936360.0 -3650000.0 -3.03 5413440.0 -3185017.5 -2.67821640829035 -5.2447 -0.9956 3562139 PK04_181299 COC(=O)C1(CCCCC1)N2CC3=CCCC=C[C@H]3[C@@H]2[C@@H](O)Cc4ccccc4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P02 compound treatment 7951360.0 -1670000.0 -1.43 8606840.0 -980000.0 -0.81 7289720.0 -1308737.5 -1.10049073408385 -1.9327 -0.9751 1015751 PK04_181300 Cc1ccncc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P03 compound treatment 6654360.0 -2960000.0 -2.55 7165280.0 -2420000.0 -2.01 6536200.0 -2062257.5 -1.73411036976087 -3.6334 -0.9872 3562141 PK04_181301 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N(CC#C)[C@H](/C=C/C3CC3)[C@@H](O)Cc4ccccc4)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P04 compound treatment 8029240.0 -1590000.0 -1.37 8953400.0 -633000.0 -0.53 7514520.0 -1083937.5 -0.911460988224154 -1.6189 -0.9384 3562143 PK04_181302 COc1cc2CCN(=Cc2cc1OC)Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P05 compound treatment 8233720.0 -1380000.0 -1.19 7857000.0 -1730000.0 -1.43 7446120.0 -1152337.5 -0.968977156448367 -2.0756 -0.9876 3562144 PK04_181303 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=CCCC=C[C@H]4[C@@H]3[C@@H](O)Cc5ccccc5)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P06 compound treatment 8369520.0 -1250000.0 -1.07 8335000.0 -1250000.0 -1.04 7840120.0 -758337.5 -0.637670573402465 -1.5879 -0.9775 1024512 PK04_181304 COc1cc2CCN=C(C)c2cc1OC 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P07 compound treatment 5449960.0 -4170000.0 -3.59 6740720.0 -2850000.0 -2.36 6055240.0 -2543217.5 -2.13853984737954 -4.6687 -0.9732 3562146 PK04_181305 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3C51CCCCC5 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P08 compound treatment 8743320.0 -875000.0 -0.75 8242880.0 -1340000.0 -1.11 7859240.0 -739217.5 -0.621592954448563 -1.437 -0.9698 3562148 PK04_181306 COc1cc2CC(C)N(=Cc2cc1OC)Cl 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P09 compound treatment 8265320.0 -1350000.0 -1.16 7517840.0 -2070000.0 -1.72 6635240.0 -1963217.5 -1.6508296489871 -2.616 -0.987 3562149 PK04_181307 COC(=O)C1(CCCC1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P10 compound treatment 8940480.0 -678000.0 -0.58 8301720.0 -1280000.0 -1.07 8491240.0 -107217.5 -0.090157014131279 -1.0041 -0.8242 1003512 PK04_181308 C[n+]1ccc2ccccc2c1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P11 mock treatment 9445600.0 -172000.0 -0.15 8611000.0 -976000.0 -0.81 7886400.0 -712057.5 -0.598754663089358 -0.8986 -0.8831 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P12 mock treatment 8972840.0 -645000.0 -0.56 8753640.0 -833000.0 -0.69 7808160.0 -790297.5 -0.664545087093194 -1.1031 -0.9958 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P13 compound treatment 7639160.0 -1980000.0 -1.7 9027120.0 -559000.0 -0.46 7584200.0 -1014257.5 -0.852868494044869 -1.7436 -0.8894 3562151 PK04_181309 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3C[C@](C)(OC)O[C@@H](Cc4ccccc4)[C@H]3/C=C/C5CC5)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P14 compound treatment 9406000.0 -212000.0 -0.18 9290280.0 -296000.0 -0.25 8043720.0 -554737.5 -0.466467476173669 -0.5165 -0.9258 1009497 PK04_181310 Cc1cc[n+](C)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P15 compound treatment 6210520.0 -3410000.0 -2.93 6884120.0 -2700000.0 -2.24 5458440.0 -3140017.5 -2.64037682393232 -4.5119 -0.9941 3562153 PK04_181311 COC(=O)[C@@H]1N[C@H](SC1(C)C)[C@@H]2N(CC#C)[C@H](/C=C/C3CC3)[C@H](Cc4ccccc4)OC2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P16 compound treatment 8644360.0 -974000.0 -0.84 8161360.0 -1430000.0 -1.18 7327720.0 -1270737.5 -1.06853730729262 -1.7833 -0.9905 1023898 PK04_181312 COc1cc2CC[N+](=Cc2cc1OC)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P17 compound treatment 7422520.0 -2200000.0 -1.89 7991960.0 -1590000.0 -1.32 6771040.0 -1827417.5 -1.53663819219108 -2.7418 -0.9893 3562155 PK04_181313 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC(=C[C@@H]3[C@@H](O)Cc4ccccc4)/C=C/C5CC5)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P18 compound treatment 8185040.0 -1430000.0 -1.23 8745120.0 -841000.0 -0.7 7676960.0 -921497.5 -0.774868497488174 -1.5624 -0.9674 1071838 PK04_181314 COc1cc2CC[N+](=C(C)c2cc1OC)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P19 compound treatment 8189920.0 -1430000.0 -1.23 8251560.0 -1330000.0 -1.11 7214000.0 -1384457.5 -1.16416214136363 -2.0211 -0.9991 3562157 PK04_181315 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)C41CCCC4 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P20 compound treatment 7875120.0 -1740000.0 -1.5 7811000.0 -1780000.0 -1.47 7808480.0 -789977.5 -0.664276005604425 -2.0999 -0.9525 1023900 PK04_181316 COc1cc2CC(C)[N+](=Cc2cc1OC)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P21 compound treatment 7946640.0 -1670000.0 -1.44 8343680.0 -1240000.0 -1.03 7609400.0 -989057.5 -0.83167832680437 -1.9059 -0.9747 3562159 PK04_181317 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=C[C@@H](C5CC5)n6n(C4[C@@H]3[C@@H](O)Cc7ccccc7)c(=O)n(C)c6=O)C2=O 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P22 compound treatment 7891200.0 -1730000.0 -1.49 7656400.0 -1930000.0 -1.6 7779840.0 -818617.5 -0.688358798849183 -2.1799 -0.9517 1107245 PK04_181318 COc1ccc(C[n+]2ccc3ccccc3c2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P23 compound treatment 7488120.0 -2130000.0 -1.83 7501200.0 -2090000.0 -1.73 8011480.0 -586977.5 -0.49357743616707 -2.342 -0.9119 3562161 PK04_181319 CC(=CCc1cc(/C=C/2\OC(=O)C(=C2O)c3cc4CCC(C)(C)Oc4cc3O)ccc1O)C 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.2181 P24 compound treatment 6616560.0 -3000000.0 -2.58 6632360.0 -2950000.0 -2.45 5844400.0 -2754057.5 -2.31583091329172 -4.2433 -0.999 3562163 PK04_181320 COc1ccc(C[n+]2ccc(C)cc2)cc1 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A01 mock treatment 7474040.0 -2070000.0 -1.78 7892320.0 -1630000.0 -1.35 8074640.0 -1165528.95833333 -0.980069585346357 -2.3759 -0.9726 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A02 mock treatment 8405240.0 -1140000.0 -0.98 8212000.0 -1310000.0 -1.09 8366360.0 -873808.95833333 -0.734768173148005 -1.6184 -0.9877 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A03 mock treatment 8167520.0 -1380000.0 -1.19 8498080.0 -1020000.0 -0.85 9182360.0 -57808.9583333302 -0.048610376788981 -1.2034 -0.8244 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A04 mock treatment 8764760.0 -781000.0 -0.67 8724480.0 -798000.0 -0.66 8717680.0 -522488.95833333 -0.439350333666569 -1.0238 -0.9839 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A05 mock treatment 8551440.0 -994000.0 -0.86 8837640.0 -685000.0 -0.57 9007080.0 -233088.95833333 -0.195999762261787 -0.9351 -0.8944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A06 mock treatment 8888360.0 -657000.0 -0.57 9041880.0 -481000.0 -0.4 8930640.0 -309528.95833333 -0.260276602891302 -0.7069 -0.9563 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A07 mock treatment 9083040.0 -462000.0 -0.4 8703640.0 -819000.0 -0.68 9003360.0 -236808.95833333 -0.199127834568718 -0.7369 -0.9074 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A08 mock treatment 9218880.0 -327000.0 -0.28 9684240.0 162000.0 0.13 8821920.0 -418248.95833333 -0.351697038700313 -0.2878 -0.6127 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A09 mock treatment 9217760.0 -328000.0 -0.28 9541280.0 18800.0 0.02 8817480.0 -422688.95833333 -0.355430544356972 -0.359 -0.7908 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A10 mock treatment 9197160.0 -348000.0 -0.3 9561000.0 38500.0 0.03 8296200.0 -943968.95833333 -0.793764289560443 -0.6129 -0.7218 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A11 mock treatment 8975560.0 -570000.0 -0.49 9697000.0 175000.0 0.14 9234600.0 -5568.95833333023 -0.00468282374756507 -0.2023 -0.3956 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A12 mock treatment 8550560.0 -995000.0 -0.86 9918920.0 396000.0 0.33 8802920.0 -437248.95833333 -0.367673752095927 -0.5167 -0.5229 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A13 mock treatment 8981400.0 -564000.0 -0.49 9427800.0 -94700.0 -0.08 9402920.0 162751.04166667 0.136854039344532 -0.2466 -0.4831 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A14 mock treatment 9125160.0 -420000.0 -0.36 9296080.0 -226000.0 -0.19 9236720.0 -3448.95833333023 -0.00290015888447545 -0.3189 -0.7826 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A15 mock treatment 8906080.0 -639000.0 -0.55 9307400.0 -215000.0 -0.18 8975120.0 -265048.95833333 -0.222874275952516 -0.5494 -0.8862 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A16 mock treatment 8945000.0 -600000.0 -0.52 9435520.0 -87000.0 -0.07 9281760.0 41591.0416666698 0.034973060659655 -0.3198 -0.6116 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A17 mock treatment 8968240.0 -577000.0 -0.5 9310960.0 -212000.0 -0.18 9161440.0 -78728.9583333302 -0.066201579117205 -0.4263 -0.8029 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A18 mock treatment 8738360.0 -807000.0 -0.69 8753880.0 -769000.0 -0.64 8930760.0 -309408.95833333 -0.260175697333014 -0.9194 -0.9399 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A19 mock treatment 8573200.0 -972000.0 -0.84 8975720.0 -547000.0 -0.45 8750280.0 -489888.95833333 -0.411937656998304 -0.9828 -0.9477 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A20 mock treatment 8659960.0 -885000.0 -0.76 8867800.0 -655000.0 -0.54 8715880.0 -524288.95833333 -0.44086391704089 -1.0081 -0.9745 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A21 mock treatment 8333080.0 -1210000.0 -1.04 8576080.0 -946000.0 -0.79 8591080.0 -649088.95833333 -0.545805697660505 -1.3708 -0.9686 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A22 mock treatment 8280200.0 -1270000.0 -1.09 8827320.0 -695000.0 -0.58 8121000.0 -1119168.95833333 -0.941086404661057 -1.505 -0.9707 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A23 mock treatment 8350040.0 -1200000.0 -1.03 8375040.0 -1150000.0 -0.95 8193040.0 -1047128.95833333 -0.880509434502106 -1.6519 -0.998 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base A24 mock treatment 7430000.0 -2120000.0 -1.82 9502240.0 -20300.0 -0.02 9509120.0 268951.04166667 0.226155458429493 -0.9303 -0.507 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B01 mock treatment 8841400.0 -704000.0 -0.61 8710080.0 -812000.0 -0.67 8557000.0 -683168.95833333 -0.574462876214324 -1.0706 -0.9978 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B02 mock treatment 8886400.0 -659000.0 -0.57 9345280.0 -177000.0 -0.15 9275760.0 35591.0416666698 0.0299277827452504 -0.3951 -0.6734 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B03 mock treatment 9377400.0 -168000.0 -0.14 9675760.0 153000.0 0.13 9004840.0 -235328.95833333 -0.197883332683165 -0.1243 -0.4503 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B04 mock treatment 9603400.0 58000.0 0.05 9793840.0 271000.0 0.23 8767760.0 -472408.95833333 -0.397239080674338 -0.0706 -0.1536 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B05 mock treatment 9262200.0 -283000.0 -0.24 9682880.0 160000.0 0.13 8708560.0 -531608.95833333 -0.447019156096464 -0.322 -0.6119 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B06 mock treatment 9750000.0 205000.0 0.18 9789680.0 267000.0 0.22 9852040.0 611871.04166667 0.514509908830763 0.5267 0.8969 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B07 mock treatment 9583000.0 37600.0 0.03 1.022972E7 707000.0 0.59 9501440.0 261271.04166667 0.219697502699055 0.4842 0.7719 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B08 mock treatment 9488840.0 -56600.0 -0.05 9997280.0 475000.0 0.39 9645600.0 405431.04166667 0.340918713389149 0.3961 0.7571 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B09 mock treatment 9756640.0 211000.0 0.18 1.034776E7 825000.0 0.68 9301560.0 61391.0416666698 0.0516224777771902 0.53 0.7463 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B10 mock treatment 9622160.0 76800.0 0.07 1.000296E7 480000.0 0.4 9744720.0 504551.04166667 0.424266704535113 0.5132 0.876 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B11 mock treatment 9936680.0 391000.0 0.34 9978920.0 456000.0 0.38 9564640.0 324471.04166667 0.272841096730783 0.5705 0.9914 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B12 mock treatment 9793400.0 248000.0 0.21 9871960.0 349000.0 0.29 1.026956E7 1029391.04166667 0.865593981301131 0.7904 0.8431 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B13 mock treatment 9543880.0 -1530.0 0.0 1.052708E7 1000000.0 0.83 9489720.0 249551.04166667 0.209842393172918 0.6015 0.7 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B14 mock treatment 1.028316E7 738000.0 0.63 1.0403E7 881000.0 0.73 1.011516E7 874991.04166667 0.735762162970453 1.2131 0.9978 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B15 mock treatment 9894480.0 349000.0 0.3 9673120.0 151000.0 0.12 9630440.0 390271.04166667 0.328170977858754 0.4351 0.9414 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B16 mock treatment 9045680.0 -500000.0 -0.43 1.0056E7 534000.0 0.44 9840320.0 600151.04166667 0.504654799304626 0.2986 0.3745 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B17 mock treatment 9376800.0 -169000.0 -0.15 9236840.0 -286000.0 -0.24 9449680.0 209511.04166667 0.176173571890792 -0.1189 -0.3613 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B18 mock treatment 9638120.0 92700.0 0.08 9525560.0 3060.0 0.0 9353160.0 112991.04166667 0.0950118678410696 0.1024 0.8251 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B19 mock treatment 9555080.0 9670.0 0.01 1.012232E7 600000.0 0.5 9736000.0 495831.04166667 0.416934233966179 0.5328 0.8207 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B20 mock treatment 9377120.0 -168000.0 -0.14 9857280.0 335000.0 0.28 1.004732E7 807151.04166667 0.678716887351585 0.4686 0.6269 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B21 mock treatment 9214160.0 -331000.0 -0.29 9037840.0 -485000.0 -0.4 9436600.0 196431.04166667 0.165174866037389 -0.3014 -0.5797 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B22 mock treatment 9219280.0 -326000.0 -0.28 9204800.0 -318000.0 -0.26 9346840.0 106671.04166667 0.0896975084378968 -0.2624 -0.6638 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B23 mock treatment 9189400.0 -356000.0 -0.31 8880960.0 -642000.0 -0.53 8866480.0 -373688.95833333 -0.314227441389335 -0.6656 -0.9649 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base B24 mock treatment 8528920.0 -1020000.0 -0.87 8513640.0 -1010000.0 -0.84 8115320.0 -1124848.95833333 -0.945862601086694 -1.5344 -0.9987 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C01 mock treatment 8175240.0 -1370000.0 -1.18 8954560.0 -568000.0 -0.47 8661120.0 -579048.95833333 -0.486910486806356 -1.234 -0.9073 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C02 mock treatment 8821520.0 -724000.0 -0.62 9293280.0 -229000.0 -0.19 8618840.0 -621328.95833333 -0.52246287850986 -0.7711 -0.9235 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C03 mock treatment 9224040.0 -321000.0 -0.28 9614360.0 91900.0 0.08 9726800.0 486631.04166667 0.409198141164092 0.1206 0.2412 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C04 mock treatment 9536360.0 -9050.0 -0.01 9756640.0 234000.0 0.19 9356000.0 115831.04166667 0.0973999660538878 0.1639 0.7537 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C05 mock treatment 9473280.0 -72100.0 -0.06 9619520.0 97000.0 0.08 9247600.0 7431.04166666977 0.00624861173364488 0.0142 0.1398 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C06 mock treatment 9382240.0 -163000.0 -0.14 1.003056E7 508000.0 0.42 9972000.0 731831.04166667 0.615381831932759 0.5176 0.6819 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C07 mock treatment 9711480.0 166000.0 0.14 1.009668E7 574000.0 0.48 9650440.0 410271.04166667 0.344988570906769 0.5567 0.9198 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C08 mock treatment 1.004692E7 502000.0 0.43 9827400.0 305000.0 0.25 9884080.0 643911.04166667 0.541451692893684 0.7078 0.9602 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C09 mock treatment 9632800.0 87400.0 0.08 1.020252E7 680000.0 0.56 9688400.0 448231.04166667 0.376908362511902 0.5867 0.8595 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C10 mock treatment 9437560.0 -108000.0 -0.09 1.011036E7 588000.0 0.49 9871720.0 631551.04166667 0.53105842039001 0.5346 0.7354 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C11 mock treatment 9647000.0 102000.0 0.09 1.073564E7 1210000.0 1.01 9662880.0 422711.04166667 0.355449113782635 0.8367 0.7813 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C12 mock treatment 9916000.0 371000.0 0.32 1.021952E7 697000.0 0.58 9723480.0 483311.04166667 0.406406420718121 0.7526 0.9706 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C13 mock treatment 9509160.0 -36200.0 -0.03 9962920.0 440000.0 0.37 9454400.0 214231.04166667 0.180142523850123 0.2969 0.7268 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C14 mock treatment 9961160.0 416000.0 0.36 1.004572E7 523000.0 0.43 9438640.0 198471.04166667 0.166890260528287 0.5535 0.9434 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C15 mock treatment 9839520.0 294000.0 0.25 9209480.0 -313000.0 -0.26 9366280.0 126111.04166667 0.106044208880568 0.0574 0.152 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C16 mock treatment 9772760.0 227000.0 0.2 1.00188E7 496000.0 0.41 9457640.0 217471.04166667 0.182866973923902 0.4563 0.9289 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C17 mock treatment 9740920.0 196000.0 0.17 9941120.0 419000.0 0.35 9517000.0 276831.04166667 0.232781590090411 0.432 0.9587 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C18 mock treatment 9956880.0 411000.0 0.35 1.013968E7 617000.0 0.51 9319600.0 79431.0416666698 0.0667919467065 0.5386 0.8603 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C19 mock treatment 9392080.0 -153000.0 -0.13 9343240.0 -179000.0 -0.15 9765880.0 525711.04166667 0.442059717979913 0.0932 0.1922 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C20 mock treatment 9873120.0 328000.0 0.28 9683720.0 161000.0 0.13 9411760.0 171591.04166667 0.144287415471755 0.3234 0.9403 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C21 mock treatment 9795560.0 250000.0 0.22 9594120.0 71600.0 0.06 9150480.0 -89688.9583333302 -0.0754176201075174 0.1151 0.4881 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C22 mock treatment 9321440.0 -224000.0 -0.19 9561680.0 39200.0 0.03 9411800.0 171631.04166667 0.144321050657851 -0.0092 -0.0379 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C23 mock treatment 9379280.0 -166000.0 -0.14 9530840.0 8340.0 0.01 9102720.0 -137448.95833333 -0.115578032306178 -0.1453 -0.7897 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base C24 mock treatment 8228360.0 -1320000.0 -1.13 8926360.0 -596000.0 -0.49 8127360.0 -1112808.95833333 -0.935738410071788 -1.4802 -0.9545 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D01 mock treatment 8684960.0 -860000.0 -0.74 8892800.0 -630000.0 -0.52 9137440.0 -102728.95833333 -0.0863826907748234 -0.779 -0.8557 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D02 mock treatment 9534760.0 -10600.0 -0.01 9615440.0 92900.0 0.08 9371360.0 131191.04166667 0.110315877514764 0.1029 0.7629 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D03 mock treatment 9482160.0 -63200.0 -0.05 9627920.0 105000.0 0.09 9296120.0 55951.0416666698 0.04704809246813 0.0462 0.4082 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D04 mock treatment 9698320.0 153000.0 0.13 9806160.0 284000.0 0.24 9509080.0 268911.04166667 0.226121823243397 0.3424 0.973 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D05 mock treatment 9569000.0 23600.0 0.02 9784960.0 262000.0 0.22 9146880.0 -93288.9583333302 -0.0784447868561602 0.0921 0.3966 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D06 mock treatment 1.025644E7 711000.0 0.61 1.069644E7 1170000.0 0.97 9212920.0 -27248.9583333302 -0.0229130946116137 0.9023 0.7844 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D07 mock treatment 9889040.0 344000.0 0.3 1.022572E7 703000.0 0.58 9178840.0 -61328.9583333302 -0.0515702731654317 0.4778 0.7282 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D08 mock treatment 1.00152E7 470000.0 0.4 1.031656E7 794000.0 0.66 9787120.0 546951.04166667 0.459920001796906 0.8793 0.9776 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D09 mock treatment 1.040144E7 856000.0 0.74 1.026968E7 747000.0 0.62 9802440.0 562271.04166667 0.472802278071685 1.0562 0.9847 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D10 mock treatment 1.03276E7 782000.0 0.67 1.034356E7 821000.0 0.68 9039280.0 -200888.95833333 -0.168923437454483 0.6844 0.7038 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D11 mock treatment 1.030576E7 760000.0 0.65 9791120.0 269000.0 0.22 9593840.0 353671.04166667 0.297394782580886 0.6782 0.9012 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D12 mock treatment 1.0044E7 499000.0 0.43 1.108836E7 1570000.0 1.3 9855040.0 614871.04166667 0.517032547787966 1.2962 0.8863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D13 mock treatment 1.006468E7 519000.0 0.45 9808960.0 286000.0 0.24 1.042092E7 1180751.04166667 0.992869525488511 0.9685 0.869 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D14 mock treatment 9768880.0 223000.0 0.19 1.052604E7 1000000.0 0.83 9547680.0 307511.04166667 0.258579777826067 0.741 0.83 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D15 mock treatment 1.002936E7 484000.0 0.42 9975000.0 453000.0 0.38 9491080.0 250911.04166667 0.210985989500183 0.579 0.9665 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D16 mock treatment 9859240.0 314000.0 0.27 9740520.0 218000.0 0.18 9675840.0 435671.04166667 0.366346914077749 0.4719 0.9635 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D17 mock treatment 9695880.0 150000.0 0.13 1.02212E7 699000.0 0.58 9699040.0 458871.04166667 0.385855322013446 0.6322 0.8926 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D18 mock treatment 1.007264E7 527000.0 0.45 1.025264E7 730000.0 0.61 1.020908E7 968911.04166667 0.814737579923933 1.0821 0.9731 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D19 mock treatment 9892520.0 347000.0 0.3 9818840.0 296000.0 0.25 9267440.0 27271.0416666698 0.0229316640372761 0.3277 0.8454 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D20 mock treatment 9682640.0 137000.0 0.12 1.04442E7 922000.0 0.76 9592680.0 352511.04166667 0.296419362184101 0.6808 0.8217 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D21 mock treatment 9513080.0 -32300.0 -0.03 9507280.0 -15200.0 -0.01 9192520.0 -47648.9583333302 -0.0400670395205893 -0.0465 -0.9225 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D22 mock treatment 9698800.0 153000.0 0.13 9243120.0 -279000.0 -0.23 9775480.0 535311.04166667 0.450132162642961 0.2023 0.3866 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D23 mock treatment 9264760.0 -281000.0 -0.24 9553040.0 30500.0 0.03 8994040.0 -246128.95833333 -0.206964832929093 -0.2443 -0.7657 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base D24 mock treatment 8989800.0 -556000.0 -0.48 9080800.0 -442000.0 -0.37 8607040.0 -633128.95833333 -0.532385258408189 -0.795 -0.9889 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E01 mock treatment 8827000.0 -718000.0 -0.62 9408720.0 -114000.0 -0.09 8434640.0 -805528.95833333 -0.677352910482081 -0.8025 -0.8705 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E02 mock treatment 9641640.0 96200.0 0.08 1.045568E7 933000.0 0.77 9548280.0 308111.04166667 0.259084305617507 0.6443 0.7853 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E03 mock treatment 9589040.0 43600.0 0.04 9907360.0 385000.0 0.32 8884280.0 -355888.95833333 -0.299259783576601 0.0332 0.0757 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E04 mock treatment 9580840.0 35400.0 0.03 1.028472E7 762000.0 0.63 9280160.0 39991.0416666698 0.0336276532158138 0.4021 0.6343 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E05 mock treatment 9408400.0 -137000.0 -0.12 9326600.0 -196000.0 -0.16 9457280.0 217111.04166667 0.182564257249037 -0.0565 -0.2082 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E06 mock treatment 9933600.0 388000.0 0.33 9635520.0 113000.0 0.09 1.005956E7 819391.04166667 0.68900925429697 0.6448 0.8359 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E07 mock treatment 1.00264E7 481000.0 0.41 9688520.0 166000.0 0.14 1.006564E7 825471.04166667 0.694121802583567 0.7193 0.8773 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E08 mock treatment 9480400.0 -65000.0 -0.06 9822840.0 300000.0 0.25 1.065772E7 1417551.04166667 1.19198982717701 0.7997 0.656 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E09 mock treatment 9917000.0 372000.0 0.32 1.011728E7 595000.0 0.49 9664040.0 423871.04166667 0.35642453417942 0.6753 0.9821 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E10 mock treatment 1.099928E7 1450000.0 1.25 9759560.0 237000.0 0.2 9790040.0 549871.04166667 0.462375370381916 1.1029 0.818 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E11 mock treatment 1.045376E7 908000.0 0.78 9708320.0 186000.0 0.15 9394200.0 154031.04166667 0.129521568775597 0.6151 0.762 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E12 mock treatment 9571120.0 25700.0 0.02 1.07038E7 1180000.0 0.98 1.05422E7 1302031.04166667 1.09485140973168 1.2107 0.8238 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E13 mock treatment 1.11392E7 1590000.0 1.37 9782160.0 260000.0 0.22 9956640.0 716471.04166667 0.602465920471883 1.2641 0.8352 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E14 mock treatment 9987400.0 442000.0 0.38 1.030876E7 786000.0 0.65 9712320.0 472151.04166667 0.397022203797328 0.8254 0.9676 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E15 mock treatment 1.025264E7 707000.0 0.61 1.052516E7 1000000.0 0.83 1.053852E7 1298351.04166667 1.09175697261084 1.462 0.9737 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E16 mock treatment 1.026308E7 718000.0 0.62 1.033796E7 815000.0 0.68 9821760.0 581591.04166667 0.489048072956068 1.0295 0.9914 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E17 mock treatment 1.061732E7 1070000.0 0.92 9275080.0 -247000.0 -0.21 1.043816E7 1197991.04166667 1.0073662906959 0.9957 0.7209 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E18 mock treatment 9646640.0 101000.0 0.09 9507640.0 -14900.0 -0.01 9509000.0 268831.04166667 0.226054552871205 0.1737 0.7161 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E19 mock treatment 1.029892E7 754000.0 0.65 1.0482E7 960000.0 0.8 9557280.0 317111.04166667 0.266652222489114 0.9879 0.9313 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E20 mock treatment 9372720.0 -173000.0 -0.15 9973120.0 451000.0 0.37 9755880.0 515711.04166667 0.433650921455906 0.3804 0.6431 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E21 mock treatment 9260000.0 -285000.0 -0.25 1.0092E7 570000.0 0.47 9117760.0 -122408.95833333 -0.10293120233407 0.0715 0.1319 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E22 mock treatment 9859320.0 314000.0 0.27 9904920.0 382000.0 0.32 9150920.0 -89248.9583333302 -0.0750476330604611 0.2958 0.6987 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E23 mock treatment 9117480.0 -428000.0 -0.37 9045160.0 -477000.0 -0.4 8877040.0 -363128.95833333 -0.305347752259983 -0.6175 -0.9944 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base E24 mock treatment 8537000.0 -1010000.0 -0.87 8637840.0 -885000.0 -0.73 9018760.0 -221408.95833333 -0.186178287921746 -1.0323 -0.8963 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F01 mock treatment 9315680.0 -230000.0 -0.2 8844320.0 -678000.0 -0.56 8975640.0 -264528.95833333 -0.222437018533267 -0.5674 -0.8915 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F02 mock treatment 9322160.0 -223000.0 -0.19 9128200.0 -394000.0 -0.33 9117440.0 -122728.95833333 -0.103200283822839 -0.3594 -0.9141 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F03 mock treatment 9899440.0 354000.0 0.3 9449840.0 -72700.0 -0.06 9880280.0 640111.04166667 0.538256350214561 0.4519 0.7271 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F04 mock treatment 9543440.0 -1970.0 0.0 1.0149E7 627000.0 0.52 9543040.0 302871.04166667 0.254678096238927 0.4461 0.7708 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F05 mock treatment 1.003236E7 487000.0 0.42 1.001888E7 496000.0 0.41 9906040.0 665871.04166667 0.559917410060405 0.803 0.9894 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F06 mock treatment 9964720.0 419000.0 0.36 1.024192E7 719000.0 0.6 9348720.0 108551.04166667 0.0912783621844103 0.6056 0.861 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F07 mock treatment 9833760.0 288000.0 0.25 9863000.0 341000.0 0.28 9380440.0 140271.04166667 0.117951064758563 0.3745 0.9503 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F08 mock treatment 1.049296E7 948000.0 0.82 9560080.0 37600.0 0.03 9793480.0 553311.04166667 0.465267996386175 0.7575 0.8063 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F09 mock treatment 1.050268E7 957000.0 0.82 1.02896E7 767000.0 0.64 9648720.0 408551.04166667 0.34354225790464 1.0414 0.95 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F10 mock treatment 1.081808E7 1270000.0 1.1 9903360.0 381000.0 0.32 1.008196E7 841791.04166667 0.707844958510747 1.2235 0.9118 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F11 mock treatment 9807920.0 263000.0 0.23 1.004116E7 519000.0 0.43 9998000.0 757831.04166667 0.637244702895179 0.7468 0.9318 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F12 mock treatment 1.002128E7 476000.0 0.41 1.063328E7 1110000.0 0.92 9413560.0 173391.04166667 0.145800998846076 0.8526 0.8369 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F13 mock treatment 1.038276E7 837000.0 0.72 9600040.0 77500.0 0.06 1.038636E7 1146191.04166667 0.96380872470154 1.0097 0.8378 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F14 mock treatment 9557640.0 12200.0 0.01 1.081376E7 1290000.0 1.07 9731960.0 491791.04166667 0.41353708017048 0.8633 0.7518 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F15 mock treatment 9502120.0 -43300.0 -0.04 9986120.0 464000.0 0.38 1.019972E7 959551.04166667 0.806866946377461 0.6664 0.7449 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F16 mock treatment 1.03874E7 842000.0 0.72 9755120.0 233000.0 0.19 9753120.0 512951.04166667 0.43133009361528 0.7788 0.9003 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F17 mock treatment 1.007328E7 528000.0 0.45 9970200.0 448000.0 0.37 9709240.0 469071.04166667 0.394432294467934 0.7044 0.9963 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F18 mock treatment 9829320.0 284000.0 0.24 1.00362E7 514000.0 0.43 9503960.0 263791.04166667 0.221816519423105 0.5152 0.9558 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F19 mock treatment 9609160.0 63800.0 0.05 9766720.0 244000.0 0.2 9331160.0 90991.0416666698 0.0765125154882528 0.1928 0.8631 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F20 mock treatment 9450120.0 -95300.0 -0.08 9632280.0 110000.0 0.09 9590760.0 350591.04166667 0.294804873251491 0.1754 0.5495 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F21 mock treatment 8827640.0 -718000.0 -0.62 9772320.0 250000.0 0.21 8913040.0 -327128.95833333 -0.275076084773555 -0.3958 -0.5596 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F22 mock treatment 9456760.0 -88600.0 -0.08 9585480.0 63000.0 0.05 9711920.0 471751.04166667 0.396685851936368 0.2151 0.5282 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F23 mock treatment 9464120.0 -81300.0 -0.07 9420760.0 -102000.0 -0.08 9246000.0 5831.04166666977 0.00490320428980366 -0.0863 -0.7863 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base F24 mock treatment 9645680.0 100000.0 0.09 9048560.0 -474000.0 -0.39 7901280.0 -1338888.95833333 -1.12584448188655 -0.8272 -0.6918 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G01 mock treatment 9215600.0 -330000.0 -0.28 8731080.0 -791000.0 -0.66 8748520.0 -491648.95833333 -0.413417605186529 -0.7816 -0.9461 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G02 mock treatment 9014200.0 -531000.0 -0.46 9763360.0 241000.0 0.2 8706920.0 -533248.95833333 -0.448398198726401 -0.4075 -0.6074 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G03 mock treatment 9522680.0 -22700.0 -0.02 9292400.0 -230000.0 -0.19 9446640.0 206471.04166667 0.173617297747493 -0.0213 -0.0822 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G04 mock treatment 9706280.0 161000.0 0.14 9568880.0 46400.0 0.04 9362440.0 122271.04166667 0.102815231015349 0.1615 0.9141 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G05 mock treatment 9957920.0 413000.0 0.36 1.005704E7 535000.0 0.44 9437840.0 197671.04166667 0.166217556806366 0.557 0.941 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G06 mock treatment 9752160.0 207000.0 0.18 1.029348E7 771000.0 0.64 9516800.0 276631.04166667 0.232613414159931 0.6063 0.8619 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G07 mock treatment 9589680.0 44300.0 0.04 9888280.0 366000.0 0.3 9095400.0 -144768.95833333 -0.121733271361752 0.1269 0.3855 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G08 mock treatment 9904760.0 359000.0 0.31 9857720.0 335000.0 0.28 9491920.0 251751.04166667 0.2116923284082 0.4613 0.9885 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G09 mock treatment 1.039936E7 854000.0 0.73 9885280.0 363000.0 0.3 9488240.0 248071.04166667 0.208597891287365 0.7185 0.875 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G10 mock treatment 1.004284E7 497000.0 0.43 9465640.0 -56900.0 -0.05 9797520.0 557351.04166667 0.468665150181874 0.4905 0.7706 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G11 mock treatment 1.043892E7 894000.0 0.77 9154040.0 -368000.0 -0.31 9528920.0 288751.04166667 0.242804875547028 0.4077 0.4727 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G12 mock treatment 9827280.0 282000.0 0.24 1.030276E7 780000.0 0.65 1.02536E7 1013431.04166667 0.852173542048815 1.0058 0.9166 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G13 mock treatment 1.022904E7 684000.0 0.59 9946600.0 424000.0 0.35 1.0314E7 1073831.04166667 0.902962673053821 1.0641 0.9386 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G14 mock treatment 1.045208E7 907000.0 0.78 9579640.0 57100.0 0.05 9838240.0 598071.04166667 0.502905769627633 0.7682 0.8265 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G15 mock treatment 9784680.0 239000.0 0.21 1.013212E7 610000.0 0.51 9330360.0 90191.0416666698 0.0758398117663322 0.4547 0.8247 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G16 mock treatment 9597560.0 52200.0 0.04 9849600.0 327000.0 0.27 9568000.0 327831.04166667 0.27566645236285 0.3417 0.8776 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G17 mock treatment 9736640.0 191000.0 0.16 9715840.0 193000.0 0.16 9269880.0 29711.0416666698 0.0249834103891339 0.202 0.874 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G18 mock treatment 9945440.0 400000.0 0.34 9357200.0 -165000.0 -0.14 9357440.0 117271.04166667 0.0986108327533449 0.1765 0.4603 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G19 mock treatment 9377360.0 -168000.0 -0.14 9654440.0 132000.0 0.11 9268840.0 28671.0416666698 0.0241088955506371 -0.0064 -0.0349 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G20 mock treatment 9598720.0 53300.0 0.05 9674560.0 152000.0 0.13 9454920.0 214751.04166667 0.180579781269372 0.2036 0.9048 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G21 mock treatment 1.018868E7 643000.0 0.55 9672440.0 150000.0 0.12 9223760.0 -16408.9583333302 -0.0137979591795894 0.3835 0.6756 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G22 mock treatment 9704800.0 159000.0 0.14 9380640.0 -142000.0 -0.12 9044480.0 -195688.95833333 -0.164550863261999 -0.0837 -0.3426 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G23 mock treatment 9219640.0 -326000.0 -0.28 8784080.0 -738000.0 -0.61 9168440.0 -71728.9583333302 -0.0603154215503997 -0.5504 -0.8137 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base G24 mock treatment 8874160.0 -671000.0 -0.58 8936160.0 -586000.0 -0.49 8594520.0 -645648.95833333 -0.542913071656247 -0.9278 -0.9975 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H01 mock treatment 9108680.0 -437000.0 -0.38 8547800.0 -975000.0 -0.81 8988400.0 -251768.95833333 -0.211707394168633 -0.8061 -0.8795 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H02 mock treatment 9490320.0 -55100.0 -0.05 9625600.0 103000.0 0.09 9586440.0 346271.04166667 0.29117227315312 0.1901 0.619 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H03 mock treatment 9387640.0 -158000.0 -0.14 9901440.0 379000.0 0.31 9745720.0 505551.04166667 0.425107584187514 0.3485 0.6385 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H04 mock treatment 9859240.0 314000.0 0.27 1.01284E7 606000.0 0.5 9723200.0 483031.04166667 0.406170974415449 0.6806 0.9718 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H05 mock treatment 9754520.0 209000.0 0.18 9519000.0 -3500.0 0.0 9532960.0 292791.04166667 0.246202029342727 0.2444 0.8013 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H06 mock treatment 9828400.0 283000.0 0.24 9584240.0 61700.0 0.05 9647200.0 407031.04166667 0.342264120832991 0.3678 0.8691 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H07 mock treatment 1.00948E7 549000.0 0.47 1.021256E7 690000.0 0.57 9607080.0 366911.04166667 0.308528029178672 0.7816 0.9721 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H08 mock treatment 1.03052E7 760000.0 0.65 9778600.0 256000.0 0.21 1.002732E7 787151.04166667 0.66189929430357 0.8823 0.9245 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H09 mock treatment 1.01326E7 587000.0 0.51 9515120.0 -7380.0 -0.01 9320400.0 80231.0416666698 0.0674646504284206 0.3272 0.6417 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H10 mock treatment 1.051688E7 971000.0 0.84 9794040.0 272000.0 0.23 1.000184E7 761671.04166667 0.640473680760398 0.9825 0.9123 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H11 mock treatment 1.077548E7 1230000.0 1.06 9880520.0 358000.0 0.3 9871480.0 631311.04166667 0.530856609273434 1.0892 0.8921 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H12 mock treatment 1.043664E7 891000.0 0.77 1.045204E7 930000.0 0.77 9544080.0 303911.04166667 0.255552611077424 1.0356 0.9269 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H13 mock treatment 1.011284E7 567000.0 0.49 1.019736E7 675000.0 0.56 1.008968E7 849511.04166667 0.714336549427281 1.0176 0.9874 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H14 mock treatment 1.004044E7 495000.0 0.43 1.004472E7 522000.0 0.43 9973360.0 733191.04166667 0.616525428260024 0.852 0.9843 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H15 mock treatment 9697480.0 152000.0 0.13 9690160.0 168000.0 0.14 9550280.0 310111.04166667 0.260766064922308 0.3064 0.948 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H16 mock treatment 1.015464E7 609000.0 0.52 1.037176E7 849000.0 0.7 9412280.0 172111.04166667 0.144724672891003 0.793 0.891 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H17 mock treatment 9806200.0 261000.0 0.22 9949760.0 427000.0 0.35 9707400.0 467231.04166667 0.392885075907517 0.5611 0.9761 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H18 mock treatment 9842560.0 297000.0 0.26 1.060448E7 1080000.0 0.9 9231160.0 -9008.95833333023 -0.0075754497518237 0.6615 0.7087 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H19 mock treatment 9676000.0 131000.0 0.11 9417240.0 -105000.0 -0.09 9123240.0 -116928.95833333 -0.0983231818389143 -0.0423 -0.2445 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H20 mock treatment 9939280.0 394000.0 0.34 9775520.0 253000.0 0.21 9257560.0 17391.0416666698 0.0146237730715565 0.3253 0.8154 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H21 mock treatment 9269800.0 -276000.0 -0.24 9938840.0 416000.0 0.35 8972320.0 -267848.95833333 -0.225228738979238 -0.0676 -0.1421 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H22 mock treatment 9319640.0 -226000.0 -0.19 9690400.0 168000.0 0.14 9291480.0 51311.0416666698 0.0431464108809905 -0.0069 -0.0282 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H23 mock treatment 8934600.0 -611000.0 -0.53 9611480.0 89000.0 0.07 8432560.0 -807608.95833333 -0.679101940159075 -0.653 -0.7575 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base H24 mock treatment 9771680.0 226000.0 0.19 8784600.0 -738000.0 -0.61 8852600.0 -387568.95833333 -0.325898850964657 -0.4291 -0.5958 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I01 mock treatment 8567720.0 -978000.0 -0.84 8272000.0 -1250000.0 -1.04 7736080.0 -1504088.95833333 -1.26475780046316 -1.8149 -0.9866 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I02 mock treatment 9350440.0 -195000.0 -0.17 9319880.0 -203000.0 -0.17 8654200.0 -585968.95833333 -0.492729374000969 -0.4784 -0.8746 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I03 mock treatment 9294360.0 -251000.0 -0.22 9988480.0 466000.0 0.39 8915320.0 -324848.95833333 -0.273158879166081 -0.0593 -0.1139 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I04 mock treatment 9822840.0 277000.0 0.24 9691920.0 169000.0 0.14 9235160.0 -5008.95833333023 -0.00421193114222064 0.2166 0.7816 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I05 mock treatment 9754640.0 209000.0 0.18 9520040.0 -2460.0 0.0 9600720.0 360551.04166667 0.303180034589403 0.2778 0.7879 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I06 mock treatment 9997600.0 452000.0 0.39 1.044604E7 924000.0 0.77 9754800.0 514631.04166667 0.432742771431313 0.9169 0.953 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I07 mock treatment 9545320.0 -89.7 0.0 9337520.0 -185000.0 -0.15 9718320.0 478151.04166667 0.402067481711733 0.1435 0.3334 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I08 mock treatment 1.034252E7 797000.0 0.69 9991160.0 469000.0 0.39 9678080.0 437911.04166667 0.368230484499126 0.8331 0.9573 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I09 mock treatment 1.046048E7 915000.0 0.79 9852880.0 330000.0 0.27 9736720.0 496551.04166667 0.417539667315907 0.854 0.9157 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I10 mock treatment 1.004604E7 501000.0 0.43 9799040.0 277000.0 0.23 9904960.0 664791.04166667 0.559009260035812 0.704 0.9486 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I11 mock treatment 1.048908E7 944000.0 0.81 1.01488E7 626000.0 0.52 9479800.0 239631.04166667 0.201500867021103 0.8852 0.8987 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I12 mock treatment 1.04756E7 930000.0 0.8 9836640.0 314000.0 0.26 9784680.0 544511.04166667 0.457868255445048 0.877 0.9151 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I13 mock treatment 1.007764E7 532000.0 0.46 1.043504E7 913000.0 0.76 9614160.0 373991.04166667 0.314481457117669 0.8831 0.9404 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I14 mock treatment 1.020492E7 660000.0 0.57 9346320.0 -176000.0 -0.15 9059400.0 -180768.95833333 -0.152004938848179 0.1556 0.2569 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I15 mock treatment 9955320.0 410000.0 0.35 9637760.0 115000.0 0.1 9702200.0 462031.04166667 0.388512501715033 0.4832 0.9058 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I16 mock treatment 9509520.0 -35900.0 -0.03 9795120.0 273000.0 0.23 9539840.0 299671.04166667 0.251987281351244 0.2582 0.7595 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I17 mock treatment 9444920.0 -100000.0 -0.09 9992240.0 470000.0 0.39 9790400.0 550231.04166667 0.46267808705678 0.4422 0.7236 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I18 mock treatment 1.01242E7 579000.0 0.5 9720640.0 198000.0 0.16 9188520.0 -51648.9583333302 -0.0434305581301923 0.3574 0.6791 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I19 mock treatment 9455640.0 -89800.0 -0.08 1.01764E7 654000.0 0.54 8997000.0 -243168.95833333 -0.204475829157987 0.1505 0.2574 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I20 mock treatment 9715160.0 170000.0 0.15 9798440.0 276000.0 0.23 9422160.0 181991.04166667 0.153032563856722 0.3049 0.978 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I21 mock treatment 9375200.0 -170000.0 -0.15 9249160.0 -273000.0 -0.23 9249400.0 9231.04166666977 0.00776219510796626 -0.211 -0.7813 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I22 mock treatment 9537680.0 -7730.0 -0.01 9471920.0 -50600.0 -0.04 8204240.0 -1035928.95833333 -0.871091582395217 -0.531 -0.6088 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I23 mock treatment 9104840.0 -441000.0 -0.38 9565800.0 43300.0 0.04 8122880.0 -1117288.95833333 -0.939505550914544 -0.7406 -0.7305 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base I24 mock treatment 8993880.0 -552000.0 -0.47 8845600.0 -677000.0 -0.56 8381160.0 -859008.95833333 -0.722323154292474 -1.0153 -0.985 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J01 mock treatment 8859240.0 -686000.0 -0.59 8763080.0 -759000.0 -0.63 8628240.0 -611928.95833333 -0.514558609777293 -1.0018 -0.9966 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J02 mock treatment 8792280.0 -753000.0 -0.65 8899720.0 -623000.0 -0.52 9169920.0 -70248.9583333302 -0.0590709196648466 -0.7066 -0.8503 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J03 mock treatment 9745360.0 200000.0 0.17 9595600.0 73100.0 0.06 9261320.0 21151.0416666698 0.0177854805645834 0.1446 0.789 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J04 mock treatment 9563160.0 17800.0 0.02 9942880.0 420000.0 0.35 9253680.0 13511.0416666698 0.0113611600202415 0.2167 0.6205 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J05 mock treatment 9506040.0 -39400.0 -0.03 8983040.0 -539000.0 -0.45 9256000.0 15831.0416666698 0.0133120008138113 -0.2703 -0.6019 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J06 mock treatment 1.078E7 1230000.0 1.06 9218960.0 -304000.0 -0.25 9272200.0 32031.0416666698 0.0269342511827037 0.4836 0.4428 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J07 mock treatment 9790200.0 245000.0 0.21 9385440.0 -137000.0 -0.11 9282160.0 41991.0416666698 0.0353094125206153 0.0764 0.3156 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J08 mock treatment 9927960.0 383000.0 0.33 9446480.0 -76000.0 -0.06 9500760.0 260591.04166667 0.219125704535423 0.2802 0.6996 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J09 mock treatment 9894920.0 350000.0 0.3 1.02056E7 683000.0 0.57 9292960.0 52791.0416666698 0.0443909127665436 0.5265 0.8186 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J10 mock treatment 1.008964E7 544000.0 0.47 1.01208E7 598000.0 0.5 9898200.0 658031.04166667 0.553324913585583 0.8764 0.9976 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J11 mock treatment 1.034056E7 795000.0 0.68 1.009692E7 574000.0 0.48 1.048748E7 1247311.04166667 1.04883847515231 1.2758 0.9521 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J12 mock treatment 1.111852E7 1570000.0 1.35 1.00354E7 513000.0 0.43 9838360.0 598191.04166667 0.503006675185921 1.3177 0.8752 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J13 mock treatment 1.009492E7 550000.0 0.47 1.016396E7 641000.0 0.53 1.021568E7 975511.04166667 0.820287385629778 1.0539 0.9703 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J14 mock treatment 1.03624E7 817000.0 0.7 1.005516E7 533000.0 0.44 1.033616E7 1095991.04166667 0.921596566151022 1.1932 0.9618 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J15 mock treatment 1.002776E7 482000.0 0.42 9665560.0 143000.0 0.12 9579280.0 339111.04166667 0.285151574841931 0.4728 0.9138 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J16 mock treatment 1.011076E7 565000.0 0.49 9739280.0 217000.0 0.18 9171600.0 -68568.9583333302 -0.0576582418488133 0.3515 0.6734 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J17 mock treatment 9986400.0 441000.0 0.38 9633000.0 111000.0 0.09 9080080.0 -160088.95833333 -0.134615547636531 0.1943 0.4705 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J18 mock treatment 9800400.0 255000.0 0.22 9292080.0 -230000.0 -0.19 9591920.0 351751.04166667 0.295780293648276 0.1871 0.4509 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J19 mock treatment 9587440.0 42000.0 0.04 9618840.0 96300.0 0.08 9521680.0 281511.04166667 0.236716906863647 0.2037 0.8069 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J20 mock treatment 9387400.0 -158000.0 -0.14 9541400.0 18900.0 0.02 9480320.0 240151.04166667 0.201938124440351 0.0471 0.1932 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J21 mock treatment 9644440.0 99000.0 0.09 8916280.0 -606000.0 -0.5 9317880.0 77711.0416666698 0.0653456337043707 -0.2034 -0.3956 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J22 mock treatment 9515880.0 -29500.0 -0.03 8917840.0 -605000.0 -0.5 9242920.0 2751.04166666977 0.0023132949604093 -0.3029 -0.6032 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J23 mock treatment 9669280.0 124000.0 0.11 8617960.0 -905000.0 -0.75 8985960.0 -254208.95833333 -0.213759140520491 -0.4951 -0.6287 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base J24 mock treatment 9565160.0 19800.0 0.02 8271120.0 -1250000.0 -1.04 8830360.0 -409808.95833333 -0.34460001443405 -0.7885 -0.7208 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K01 mock treatment 8946960.0 -598000.0 -0.52 7639080.0 -1880000.0 -1.56 8639800.0 -600368.95833333 -0.50483804099554 -1.4909 -0.8664 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K02 mock treatment 8992240.0 -553000.0 -0.48 8884480.0 -638000.0 -0.53 8631680.0 -608488.95833333 -0.511665983773034 -0.8759 -0.999 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K03 mock treatment 9149600.0 -396000.0 -0.34 9811000.0 289000.0 0.24 9293560.0 53391.0416666698 0.0448954405579841 -0.0326 -0.0778 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K04 mock treatment 9203480.0 -342000.0 -0.29 9422680.0 -99800.0 -0.08 9303200.0 63031.0416666698 0.0530015204071274 -0.1871 -0.6031 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K05 mock treatment 9386880.0 -159000.0 -0.14 9172360.0 -350000.0 -0.29 9268680.0 28511.0416666698 0.023974354806253 -0.2326 -0.7229 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K06 mock treatment 9811360.0 266000.0 0.23 9591800.0 69300.0 0.06 8852720.0 -387448.95833333 -0.325797945406369 -0.0228 -0.0566 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K07 mock treatment 1.005964E7 514000.0 0.44 9598280.0 75800.0 0.06 9695800.0 455631.04166667 0.383130871939668 0.513 0.8714 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K08 mock treatment 9932840.0 387000.0 0.33 9220400.0 -302000.0 -0.25 9418120.0 177951.04166667 0.149635410061023 0.1342 0.3029 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K09 mock treatment 9157200.0 -388000.0 -0.33 9401640.0 -121000.0 -0.1 9357040.0 116871.04166667 0.0982744808923846 -0.194 -0.5354 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K10 mock treatment 9530560.0 -14800.0 -0.01 9922640.0 400000.0 0.33 9330440.0 90271.0416666698 0.0759070821385243 0.2281 0.6694 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K11 mock treatment 1.023704E7 692000.0 0.6 9396640.0 -126000.0 -0.1 9246960.0 6791.04166666977 0.00571044875610839 0.2867 0.4744 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K12 mock treatment 9899200.0 354000.0 0.3 1.0162E7 640000.0 0.53 9626280.0 386111.04166667 0.324672918504767 0.6695 0.9668 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K13 mock treatment 9462480.0 -82900.0 -0.07 9496440.0 -26100.0 -0.02 9025800.0 -214368.95833333 -0.180258495168845 -0.1578 -0.8087 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K14 mock treatment 1.00256E7 480000.0 0.41 9826440.0 304000.0 0.25 9565000.0 324831.04166667 0.273143813405648 0.5419 0.9748 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K15 mock treatment 9986520.0 441000.0 0.38 9505360.0 -17100.0 -0.01 9390760.0 150591.04166667 0.126628942771338 0.2841 0.7094 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K16 mock treatment 9550960.0 5550.0 0.0 9411400.0 -111000.0 -0.09 9189760.0 -50408.9583333302 -0.0423878673612154 -0.0749 -0.7378 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K17 mock treatment 9217760.0 -328000.0 -0.28 9594520.0 72000.0 0.06 9573480.0 333311.04166667 0.280274472858006 0.0335 0.0833 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K18 mock treatment 9771360.0 226000.0 0.19 9547720.0 25200.0 0.02 9082920.0 -157248.95833333 -0.132227449423713 0.048 0.2034 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K19 mock treatment 9596680.0 51300.0 0.04 9498640.0 -23900.0 -0.02 9021120.0 -219048.95833333 -0.18419381194208 -0.0923 -0.4846 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K20 mock treatment 9857560.0 312000.0 0.27 9404360.0 -118000.0 -0.1 8944800.0 -295368.95833333 -0.248369747013307 -0.0449 -0.1185 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K21 mock treatment 9228040.0 -317000.0 -0.27 8923480.0 -599000.0 -0.5 8650640.0 -589528.95833333 -0.495722905563516 -0.7308 -0.9703 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K22 mock treatment 9230320.0 -315000.0 -0.27 9240600.0 -282000.0 -0.23 8516320.0 -723848.95833333 -0.608669860473987 -0.643 -0.9105 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K23 mock treatment 9535080.0 -10300.0 -0.01 9457040.0 -65500.0 -0.05 8447880.0 -792288.95833333 -0.666219663884295 -0.4211 -0.63 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base K24 mock treatment 9034040.0 -511000.0 -0.44 9086880.0 -436000.0 -0.36 8393360.0 -846808.95833333 -0.712064422533185 -0.8738 -0.9584 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L01 mock treatment 9125160.0 -420000.0 -0.36 8975680.0 -547000.0 -0.45 8309400.0 -930768.95833333 -0.782664678148753 -0.9226 -0.947 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L02 mock treatment 9684520.0 139000.0 0.12 9329120.0 -193000.0 -0.16 9697720.0 457551.04166667 0.384745360872277 0.1986 0.458 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L03 mock treatment 9863240.0 318000.0 0.27 9778040.0 256000.0 0.21 9015680.0 -224488.95833333 -0.188768197251141 0.1713 0.4346 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L04 mock treatment 9971600.0 426000.0 0.37 1.00562E7 534000.0 0.44 9580520.0 340351.04166667 0.286194265610908 0.6326 0.985 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L05 mock treatment 9412320.0 -133000.0 -0.11 9995200.0 473000.0 0.39 9470800.0 230631.04166667 0.193932950149496 0.2722 0.602 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L06 mock treatment 9774240.0 229000.0 0.2 9742080.0 220000.0 0.18 9131400.0 -108768.95833333 -0.091461603875324 0.1661 0.5859 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L07 mock treatment 9699880.0 154000.0 0.13 9982320.0 460000.0 0.38 9262960.0 22791.0416666698 0.0191645231945206 0.3081 0.7617 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L08 mock treatment 1.027428E7 729000.0 0.63 9974960.0 452000.0 0.38 9569800.0 329631.04166667 0.277180035737171 0.7389 0.9451 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L09 mock treatment 1.00224E7 477000.0 0.41 9366200.0 -156000.0 -0.13 9440440.0 200271.04166667 0.168403843902608 0.2594 0.5611 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L10 mock treatment 1.018336E7 638000.0 0.55 1.04972E7 975000.0 0.81 9054720.0 -185448.95833333 -0.155940255621415 0.6938 0.701 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L11 mock treatment 9788120.0 243000.0 0.21 9507840.0 -14700.0 -0.01 9355480.0 115311.04166667 0.0969627086346394 0.1696 0.7353 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L12 mock treatment 9708920.0 164000.0 0.14 9351800.0 -171000.0 -0.14 9681640.0 441471.04166667 0.371224016061673 0.2138 0.5073 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L13 mock treatment 1.00318E7 486000.0 0.42 1.07682E7 1250000.0 1.03 9277440.0 37271.0416666698 0.0313404605612837 0.8564 0.7678 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L14 mock treatment 1.005156E7 506000.0 0.44 9798960.0 276000.0 0.23 9369840.0 129671.04166667 0.109037740443114 0.4469 0.8862 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L15 mock treatment 1.005696E7 512000.0 0.44 9570240.0 47700.0 0.04 9353240.0 113071.04166667 0.0950791382132617 0.3319 0.7342 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L16 mock treatment 1.012256E7 577000.0 0.5 9110960.0 -412000.0 -0.34 8900320.0 -339848.95833333 -0.285772073952093 -0.0753 -0.1129 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L17 mock treatment 9990000.0 445000.0 0.38 9566640.0 44100.0 0.04 9323520.0 83351.0416666698 0.070088194943911 0.2825 0.7231 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L18 mock treatment 9599520.0 54100.0 0.05 8551200.0 -971000.0 -0.81 9317400.0 77231.0416666698 0.0649420114712183 -0.4008 -0.495 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L19 mock treatment 9202840.0 -343000.0 -0.29 9297720.0 -225000.0 -0.19 9459320.0 219151.04166667 0.184279651739935 -0.1715 -0.4347 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L20 mock treatment 9256480.0 -289000.0 -0.25 9627480.0 105000.0 0.09 9733920.0 493751.04166667 0.415185204289185 0.1464 0.2978 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L21 mock treatment 9605160.0 59800.0 0.05 9091440.0 -431000.0 -0.36 9395960.0 155791.04166667 0.131001516963822 -0.1011 -0.2632 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L22 mock treatment 9288000.0 -257000.0 -0.22 9240200.0 -282000.0 -0.23 9259920.0 19751.0416666698 0.0166082490512223 -0.2535 -0.7854 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L23 mock treatment 9558880.0 13500.0 0.01 9459560.0 -62900.0 -0.05 9142280.0 -97888.9583333302 -0.0823128332572037 -0.071 -0.723 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base L24 mock treatment 8481520.0 -1060000.0 -0.92 8763280.0 -759000.0 -0.63 8282680.0 -957488.95833333 -0.805132982460901 -1.3571 -0.9889 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M01 mock treatment 8752760.0 -793000.0 -0.68 8128160.0 -1390000.0 -1.16 8582520.0 -657648.95833333 -0.553003627485056 -1.381 -0.9509 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M02 mock treatment 8592600.0 -953000.0 -0.82 9121920.0 -401000.0 -0.33 8631640.0 -608528.95833333 -0.51169961895913 -0.9607 -0.9399 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M03 mock treatment 8719880.0 -826000.0 -0.71 8695120.0 -827000.0 -0.69 8823200.0 -416968.95833333 -0.35062071274524 -1.0089 -0.9625 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M04 mock treatment 9138080.0 -407000.0 -0.35 9335000.0 -187000.0 -0.16 9188680.0 -51488.9583333302 -0.0432960173858082 -0.3172 -0.8218 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M05 mock treatment 9255080.0 -290000.0 -0.25 9123840.0 -399000.0 -0.33 9366520.0 126351.04166667 0.106246019997144 -0.2739 -0.64 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M06 mock treatment 9663840.0 118000.0 0.1 9212840.0 -310000.0 -0.26 8965480.0 -274688.95833333 -0.230980355801659 -0.2228 -0.6186 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M07 mock treatment 9571400.0 26000.0 0.02 8775840.0 -747000.0 -0.62 9201920.0 -38248.9583333302 -0.0321627707880221 -0.3633 -0.5853 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M08 mock treatment 1.006728E7 522000.0 0.45 9397840.0 -125000.0 -0.1 8999440.0 -240728.95833333 -0.202424082806129 0.0827 0.1644 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M09 mock treatment 9443400.0 -102000.0 -0.09 8821880.0 -701000.0 -0.58 9064200.0 -175968.95833333 -0.147968716516655 -0.4717 -0.7782 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M10 mock treatment 9942640.0 397000.0 0.34 9237920.0 -285000.0 -0.24 8902200.0 -337968.95833333 -0.284191220205579 -0.103 -0.2046 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M11 mock treatment 1.023692E7 692000.0 0.6 9159680.0 -363000.0 -0.3 9548360.0 308191.04166667 0.259151575989699 0.3195 0.4465 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M12 mock treatment 9869720.0 324000.0 0.28 9787680.0 265000.0 0.22 9377520.0 137351.04166667 0.115495696173552 0.3548 0.9496 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M13 mock treatment 9635280.0 89900.0 0.08 9712400.0 190000.0 0.16 9633120.0 392951.04166667 0.330424535327188 0.3264 0.8723 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M14 mock treatment 9337160.0 -208000.0 -0.18 9405920.0 -117000.0 -0.1 9286880.0 46711.0416666698 0.0392783644799469 -0.1366 -0.6588 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M15 mock treatment 9759240.0 214000.0 0.18 9512360.0 -10100.0 -0.01 9044160.0 -196008.95833333 -0.164819944750767 0.0062 0.0252 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M16 mock treatment 9353840.0 -192000.0 -0.16 9556360.0 33900.0 0.03 9607160.0 366991.04166667 0.308595299550864 0.0992 0.2826 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M17 mock treatment 9909200.0 364000.0 0.31 9608840.0 86300.0 0.07 9716240.0 476071.04166667 0.400318452034739 0.4532 0.8831 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M18 mock treatment 9583800.0 38400.0 0.03 8782400.0 -740000.0 -0.61 9322320.0 82151.0416666698 0.0690791393610301 -0.2955 -0.4776 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M19 mock treatment 9716520.0 171000.0 0.15 9241360.0 -281000.0 -0.23 8863920.0 -376248.95833333 -0.316380093299481 -0.2323 -0.5534 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M20 mock treatment 9099480.0 -446000.0 -0.38 8613680.0 -909000.0 -0.75 9564240.0 324071.04166667 0.272504744869823 -0.4995 -0.562 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M21 mock treatment 9009240.0 -536000.0 -0.46 9177240.0 -345000.0 -0.29 8758880.0 -481288.95833333 -0.404706091987657 -0.6654 -0.9825 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M22 mock treatment 8875760.0 -670000.0 -0.58 9208680.0 -314000.0 -0.26 8760000.0 -480168.95833333 -0.403764306776968 -0.7162 -0.9545 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M23 mock treatment 9083400.0 -462000.0 -0.4 9564800.0 42300.0 0.04 9008240.0 -231928.95833333 -0.195024341865002 -0.3219 -0.7246 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base M24 mock treatment 8577080.0 -968000.0 -0.83 8728120.0 -794000.0 -0.66 9187320.0 -52848.9583333302 -0.0444396137130732 -0.8873 -0.8344 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N01 mock treatment 8117640.0 -1430000.0 -1.23 9146920.0 -376000.0 -0.31 8484320.0 -755848.95833333 -0.635578009350811 -1.2563 -0.8859 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N02 mock treatment 8518160.0 -1030000.0 -0.88 9410640.0 -112000.0 -0.09 8668760.0 -571408.95833333 -0.480486166262014 -0.8414 -0.8327 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N03 mock treatment 9178480.0 -367000.0 -0.32 9490040.0 -32500.0 -0.03 9006800.0 -233368.95833333 -0.196235208564459 -0.3112 -0.8347 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N04 mock treatment 9355200.0 -190000.0 -0.16 9433600.0 -88900.0 -0.07 1.00996E7 859431.04166667 0.722678075579097 0.2801 0.3762 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N05 mock treatment 8695160.0 -850000.0 -0.73 9532040.0 9540.0 0.01 8594680.0 -645488.95833333 -0.542778530911863 -0.7313 -0.8026 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N06 mock treatment 8971240.0 -574000.0 -0.49 9489400.0 -33100.0 -0.03 9015160.0 -225008.95833333 -0.189205454670389 -0.4104 -0.7745 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N07 mock treatment 9522440.0 -23000.0 -0.02 9626080.0 104000.0 0.09 9233880.0 -6288.95833333023 -0.00528825709729362 0.0351 0.3979 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N08 mock treatment 9530000.0 -15400.0 -0.01 9186800.0 -336000.0 -0.28 9497160.0 256991.04166667 0.21609853778678 -0.0437 -0.1238 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N09 mock treatment 9612840.0 67400.0 0.06 9597080.0 74600.0 0.06 8831640.0 -408528.95833333 -0.343523688478977 -0.1291 -0.3649 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N10 mock treatment 9805360.0 260000.0 0.22 9485560.0 -36900.0 -0.03 8663040.0 -577128.95833333 -0.485295997873746 -0.1687 -0.3152 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N11 mock treatment 9672840.0 127000.0 0.11 9441720.0 -80800.0 -0.07 9173160.0 -67008.9583333302 -0.0563464695910681 -0.0079 -0.0563 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N12 mock treatment 9972960.0 428000.0 0.37 9624960.0 102000.0 0.09 9409000.0 168831.04166667 0.141966587631128 0.3435 0.8514 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N13 mock treatment 9563280.0 17900.0 0.02 9621560.0 99100.0 0.08 9273400.0 33231.0416666698 0.0279433067655846 0.0725 0.822 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N14 mock treatment 1.005756E7 512000.0 0.44 9507400.0 -15100.0 -0.01 9209720.0 -30448.9583333302 -0.0256039094992961 0.2325 0.5263 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N15 mock treatment 9872560.0 327000.0 0.28 9371680.0 -151000.0 -0.13 9218480.0 -21688.9583333302 -0.0182378037442654 0.0798 0.2585 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N16 mock treatment 1.09134E7 1370000.0 1.18 9587920.0 65400.0 0.05 8912280.0 -327888.95833333 -0.27571515330938 0.5519 0.456 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N17 mock treatment 9419440.0 -126000.0 -0.11 9248880.0 -274000.0 -0.23 8741080.0 -499088.95833333 -0.419673749800391 -0.4359 -0.891 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N18 mock treatment 1.03038E7 758000.0 0.65 9870120.0 348000.0 0.29 8966600.0 -273568.95833333 -0.23003857059097 0.4105 0.5476 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N19 mock treatment 9759040.0 214000.0 0.18 8725080.0 -797000.0 -0.66 8657680.0 -582488.95833333 -0.489803112810615 -0.5586 -0.6623 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N20 mock treatment 1.006528E7 520000.0 0.45 8687840.0 -835000.0 -0.69 8995080.0 -245088.95833333 -0.206090318090596 -0.2604 -0.3065 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N21 mock treatment 9015920.0 -529000.0 -0.46 9120640.0 -402000.0 -0.33 9085480.0 -154688.95833333 -0.130074797513567 -0.5307 -0.9159 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N22 mock treatment 8511920.0 -1030000.0 -0.89 8873800.0 -649000.0 -0.54 8858040.0 -382128.95833333 -0.321324465655597 -1.0097 -0.928 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N23 mock treatment 9095560.0 -450000.0 -0.39 8741080.0 -781000.0 -0.65 8346560.0 -893608.95833333 -0.751417590265541 -1.0316 -0.9684 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base N24 mock treatment 8192880.0 -1350000.0 -1.16 7819280.0 -1700000.0 -1.41 8150040.0 -1090128.95833333 -0.916667259555339 -2.0171 -0.9852 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O01 mock treatment 8326560.0 -1220000.0 -1.05 8217520.0 -1300000.0 -1.08 8648360.0 -591808.95833333 -0.49764011117099 -1.518 -0.9562 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O02 mock treatment 8841640.0 -704000.0 -0.61 9472960.0 -49500.0 -0.04 8205760.0 -1034408.95833333 -0.869813445323568 -0.8756 -0.8255 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O03 mock treatment 9110920.0 -434000.0 -0.37 9364360.0 -158000.0 -0.13 8448720.0 -791448.95833333 -0.665513324976278 -0.6759 -0.8726 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O04 mock treatment 9910760.0 365000.0 0.31 9197760.0 -325000.0 -0.27 9088040.0 -152128.95833333 -0.127922145603421 -0.0479 -0.1104 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O05 mock treatment 8836600.0 -709000.0 -0.61 9407720.0 -115000.0 -0.1 8735760.0 -504408.95833333 -0.424147229551163 -0.6521 -0.8705 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O06 mock treatment 9474680.0 -70700.0 -0.06 9847840.0 325000.0 0.27 8967440.0 -272728.95833333 -0.229332231682954 -0.0117 -0.0326 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O07 mock treatment 9041160.0 -504000.0 -0.43 9651920.0 129000.0 0.11 9503040.0 262871.04166667 0.221042910142896 -0.0609 -0.1222 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O08 mock treatment 9388400.0 -157000.0 -0.14 8618160.0 -904000.0 -0.75 9248320.0 8151.04166666977 0.00685404508337343 -0.5072 -0.6653 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O09 mock treatment 9761240.0 216000.0 0.19 8967760.0 -555000.0 -0.46 9703520.0 463351.04166667 0.389622462856202 0.0665 0.1054 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O10 mock treatment 9873520.0 328000.0 0.28 1.0452E7 930000.0 0.77 9434040.0 193871.04166667 0.163022214127244 0.7023 0.8389 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O11 mock treatment 9620400.0 75000.0 0.06 1.014164E7 619000.0 0.51 9751520.0 511351.04166667 0.429984686171438 0.5821 0.8649 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O12 mock treatment 1.017896E7 634000.0 0.55 1.032572E7 803000.0 0.67 9658160.0 417991.04166667 0.351480161823303 0.9024 0.9704 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O13 mock treatment 1.009364E7 548000.0 0.47 9259400.0 -263000.0 -0.22 9105800.0 -134368.95833333 -0.112988122976784 0.0812 0.1526 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O14 mock treatment 1.040968E7 864000.0 0.74 1.06762E7 1150000.0 0.96 9719080.0 478911.04166667 0.402706550247558 1.2145 0.9509 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O15 mock treatment 9504200.0 -41200.0 -0.04 9778720.0 256000.0 0.21 8733920.0 -506248.95833333 -0.42569444811158 -0.1435 -0.3008 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O16 mock treatment 9364680.0 -181000.0 -0.16 9848520.0 326000.0 0.27 8730920.0 -509248.95833333 -0.428217087068782 -0.1809 -0.3414 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O17 mock treatment 9148960.0 -396000.0 -0.34 9020840.0 -502000.0 -0.42 8945360.0 -294808.95833333 -0.247898854407962 -0.5804 -0.9795 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O18 mock treatment 9551360.0 5950.0 0.01 8487520.0 -1030000.0 -0.86 8620360.0 -619808.95833333 -0.521184741438211 -0.7937 -0.7902 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O19 mock treatment 9310480.0 -235000.0 -0.2 9268760.0 -254000.0 -0.21 8372440.0 -867728.95833333 -0.729655624861409 -0.6595 -0.8392 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O20 mock treatment 9104560.0 -441000.0 -0.38 9027560.0 -495000.0 -0.41 8904760.0 -335408.95833333 -0.282038568295433 -0.6189 -0.9885 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O21 mock treatment 8990400.0 -555000.0 -0.48 9240000.0 -282000.0 -0.23 8644200.0 -595968.95833333 -0.501138170524977 -0.7004 -0.9583 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O22 mock treatment 8971040.0 -574000.0 -0.49 9040720.0 -482000.0 -0.4 8776080.0 -464088.95833333 -0.390242961966364 -0.7415 -0.994 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O23 mock treatment 8904160.0 -641000.0 -0.55 9163880.0 -359000.0 -0.3 8965440.0 -274728.95833333 -0.231013990987755 -0.6238 -0.9335 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base O24 mock treatment 8181120.0 -1360000.0 -1.17 8375280.0 -1150000.0 -0.95 7653600.0 -1586568.95833333 -1.33411355419317 -1.9976 -0.9909 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P01 mock treatment 7746240.0 -1800000.0 -1.55 8056080.0 -1470000.0 -1.22 8152800.0 -1087368.95833333 -0.914346431714713 -2.1242 -0.9784 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P02 mock treatment 8180080.0 -1370000.0 -1.18 9062000.0 -460000.0 -0.38 8448640.0 -791528.95833333 -0.66558059534847 -1.2832 -0.9143 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P03 mock treatment 8628320.0 -917000.0 -0.79 8780360.0 -742000.0 -0.62 8059560.0 -1180608.95833333 -0.99275005050456 -1.3843 -0.9819 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P04 mock treatment 8071480.0 -1470000.0 -1.27 9675880.0 153000.0 0.13 8643000.0 -597168.95833333 -0.502147226107858 -0.9488 -0.6925 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P05 mock treatment 8368760.0 -1180000.0 -1.01 9399560.0 -123000.0 -0.1 7997960.0 -1242208.95833333 -1.04454823709245 -1.2466 -0.8548 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P06 mock treatment 8594520.0 -951000.0 -0.82 9033600.0 -489000.0 -0.41 8642160.0 -598008.95833333 -0.502853565015874 -0.997 -0.9562 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P07 mock treatment 8917640.0 -628000.0 -0.54 9138160.0 -384000.0 -0.32 8726880.0 -513288.95833333 -0.431614240864482 -0.7452 -0.9786 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P08 mock treatment 8950320.0 -595000.0 -0.51 1.102812E7 1510000.0 1.25 8612000.0 -628168.95833333 -0.528214495332281 0.1205 0.0831 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P09 mock treatment 1.09338E7 1390000.0 1.19 8883640.0 -639000.0 -0.53 8604200.0 -635968.95833333 -0.534773356621007 0.0751 0.0532 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P10 mock treatment 9159760.0 -386000.0 -0.33 8379440.0 -1140000.0 -0.95 8644680.0 -595488.95833333 -0.500734548291825 -1.0282 -0.916 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P11 mock treatment 9267360.0 -278000.0 -0.24 9344320.0 -178000.0 -0.15 8841560.0 -398608.95833333 -0.335182162327162 -0.417 -0.953 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P12 mock treatment 9183440.0 -362000.0 -0.31 8849640.0 -673000.0 -0.56 8657560.0 -582608.95833333 -0.489904018368903 -0.785 -0.9747 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P13 mock treatment 9159600.0 -386000.0 -0.33 8930400.0 -592000.0 -0.49 8442480.0 -797688.95833333 -0.670760414007259 -0.8626 -0.9635 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P14 mock treatment 9043440.0 -502000.0 -0.43 8737240.0 -785000.0 -0.65 8788040.0 -452128.95833333 -0.380186041323651 -0.845 -0.9722 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P15 mock treatment 9239600.0 -306000.0 -0.26 8868040.0 -654000.0 -0.54 8623200.0 -616968.95833333 -0.518796643225393 -0.7649 -0.9613 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P16 mock treatment 9466000.0 -79400.0 -0.07 8751760.0 -771000.0 -0.64 8597960.0 -642208.95833333 -0.540020445651988 -0.7204 -0.8579 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P17 mock treatment 8756280.0 -789000.0 -0.68 8309440.0 -1210000.0 -1.01 8446760.0 -793408.95833333 -0.667161449094984 -1.3583 -0.9805 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P18 mock treatment 8843800.0 -702000.0 -0.6 8437120.0 -1090000.0 -0.9 9363760.0 123591.04166667 0.103925192156518 -0.8085 -0.7423 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P19 mock treatment 8661280.0 -884000.0 -0.76 7975240.0 -1550000.0 -1.28 8585480.0 -654688.95833333 -0.55051462371395 -1.4982 -0.942 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P20 mock treatment 9128680.0 -417000.0 -0.36 8026720.0 -1500000.0 -1.24 9685320.0 445151.04166667 0.374318453182508 -0.7074 -0.526 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P21 mock treatment 9158200.0 -387000.0 -0.33 9355400.0 -167000.0 -0.14 9204760.0 -35408.9583333302 -0.0297746725752039 -0.2896 -0.7997 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P22 mock treatment 8723960.0 -821000.0 -0.71 8327400.0 -1200000.0 -0.99 8092120.0 -1148048.95833333 -0.965371009022391 -1.5379 -0.9897 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P23 mock treatment 8620320.0 -925000.0 -0.8 7854760.0 -1670000.0 -1.38 8678800.0 -561368.95833333 -0.47204373455191 -1.531 -0.9197 1054.0006 CellTiterGlo(1054.0006) KRasSyntheticLethal 1054.0006.Base P24 mock treatment 7718440.0 -1830000.0 -1.57 7604640.0 -1920000.0 -1.59 7976320.0 -1263848.95833333 -1.0627448727704 -2.4399 -0.9852