ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A01 mock treatment 0.345 -0.0315 -1.61 0.341 -0.0261 -1.58 -2.2524 -1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A02 mock treatment 0.34 -0.0365 -1.86 0.339 -0.0281 -1.7 -2.5185 -0.9989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A03 compound treatment 0.341 -0.0355 -1.81 0.336 -0.0311 -1.88 -2.6104 -0.9998 1907838 Bionet1_000081 CN(C)/C=N\C(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A04 compound treatment 0.324 -0.0525 -2.68 0.338 -0.0291 -1.76 -3.1397 -0.979 1156141 Bionet1_000082 COc1ccc(cc1)n2nc(C(=O)Nc3ccccc3)c4ccccc4c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A05 compound treatment 0.337 -0.0395 -2.02 0.341 -0.0261 -1.58 -2.5416 -0.9926 1907839 Bionet1_000083 O/N=C/NC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A06 compound treatment 0.331 -0.0455 -2.32 0.339 -0.0281 -1.7 -2.8439 -0.9881 1210239 Bionet1_000084 COc1ccc(cc1)n2nc(C(=O)Oc3ccccc3)c4ccccc4c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A07 compound treatment 0.335 -0.0415 -2.12 0.339 -0.0281 -1.7 -2.6993 -0.994 1907840 Bionet1_000085 CO/N=C/NC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A08 compound treatment 0.328 -0.0485 -2.48 0.338 -0.0291 -1.76 -2.9951 -0.9859 1907841 Bionet1_000086 FC(F)(F)c1nc2oc3ccccc3c(=O)c2cc1C(=O)NCc4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A09 compound treatment 0.322 -0.0545 -2.78 0.333 -0.0341 -2.06 -3.4254 -0.989 1907842 Bionet1_000087 Clc1ccc(NC(=O)n2ccc(n2)c3ccc(cc3)n4ccnc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A10 compound treatment 0.341 -0.0355 -1.81 0.333 -0.0341 -2.06 -2.7385 -0.998 1907843 Bionet1_000088 FC(F)(F)c1nc2oc3ccccc3c(=O)c2cc1C(=O)NCc4cccnc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A11 compound treatment 0.343 -0.0335 -1.71 0.341 -0.0261 -1.58 -2.3247 -0.9992 1907844 Bionet1_000089 C/C(=N\OC(=O)Nc1ccc(Cl)cc1)/c2ccc(cc2)n3ccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A12 compound treatment 0.332 -0.0445 -2.27 0.338 -0.0291 -1.76 -2.8504 -0.9919 1907845 Bionet1_000090 CC(C)NC(=O)c1cc2c(=O)c3ccccc3oc2nc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A13 compound treatment 0.351 -0.0255 -1.3 0.351 -0.0161 -0.97 -1.6086 -0.9898 1907846 Bionet1_000091 Oc1ccc(Cl)cc1N/C=C\2/Sc3cc(Cl)ccc3NC2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A14 compound treatment 0.326 -0.0505 -2.58 0.335 -0.0321 -1.94 -3.1954 -0.9901 1907847 Bionet1_000092 CN(C)C(=O)Nc1cc2c(=O)c3ccccc3oc2nc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A15 compound treatment 0.331 -0.0455 -2.32 0.338 -0.0291 -1.76 -2.8866 -0.9905 1907848 Bionet1_000093 CN(C)/C=N/S(=O)(=O)c1ccc(Oc2c(Cl)c(Cl)nn2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A16 compound treatment 0.333 -0.0435 -2.22 0.345 -0.0221 -1.34 -2.5155 -0.9703 1907849 Bionet1_000094 CON(C)C(=O)Nc1cc2c(=O)c3ccccc3oc2nc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A17 compound treatment 0.334 -0.0425 -2.17 0.337 -0.0301 -1.82 -2.8208 -0.9961 1409233 Bionet1_000095 Clc1ccc(cc1)C2CC(=O)C3=C(C2)OC(=O)CC3c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A18 compound treatment 0.355 -0.0215 -1.1 0.355 -0.0121 -0.73 -1.2932 -0.9807 1907850 Bionet1_000096 CCSC(=O)Nc1cc2c(=O)c3ccccc3oc2nc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A19 compound treatment 0.325 -0.0515 -2.63 0.334 -0.0331 -2.0 -3.2743 -0.9908 1907851 Bionet1_000097 FC(F)(F)c1ccccc1N/C=C\2/Sc3cc(Cl)ccc3NC2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A20 compound treatment 0.325 -0.0515 -2.63 0.335 -0.0321 -1.94 -3.2316 -0.9887 1516152 Bionet1_000098 O=c1n(Cc2cccnc2)ccc3nc4oc5ccccc5c(=O)c4cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A21 compound treatment 0.322 -0.0545 -2.78 0.338 -0.0291 -1.76 -3.212 -0.9754 1907852 Bionet1_000099 FC(F)(F)c1cccc(N/C=C\2/Sc3cc(Cl)ccc3NC2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A22 compound treatment 0.355 -0.0215 -1.1 0.334 -0.0331 -2.0 -2.1896 -0.96 1736385 Bionet1_000100 O=c1n(Cc2ccncc2)ccc3nc4oc5ccccc5c(=O)c4cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A23 positive control 0.092 -0.284 -14.54 0.088 -0.279 -16.85 -22.1996 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 A24 positive control 0.086 -0.29 -14.85 0.091 -0.276 -16.67 -22.2885 -0.9983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B01 mock treatment 0.377 5.48E-4 0.03 0.366 -0.00112 -0.07 -0.0282 -0.3837 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B02 mock treatment 0.376 -4.52E-4 -0.02 0.376 0.00888 0.54 0.3625 0.676 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B03 compound treatment 0.382 0.00555 0.28 0.373 0.00588 0.35 0.4514 0.9939 1907853 Bionet1_000101 Clc1ccc(cc1)c2nc(nc(N3CCOCC3)c2C#N)c4cccnc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B04 compound treatment 0.379 0.00255 0.13 0.376 0.00888 0.54 0.471 0.8542 1907854 Bionet1_000102 FC(F)(F)c1cccc(Cn2cc(ccc2=O)C(=O)Nc3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B05 compound treatment 0.386 0.00955 0.49 0.373 0.00588 0.35 0.596 0.9877 1907855 Bionet1_000103 CC(C)Nc1nc(nc(c1C#N)c2ccc(Cl)cc2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B06 compound treatment 0.349 -0.0275 -1.4 0.358 -0.00912 -0.55 -1.3821 -0.9166 1568869 Bionet1_000104 Clc1cccc(Cl)c1Cn2cc(NC(=O)Nc3ccccc3)ccc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B07 compound treatment 0.376 -4.52E-4 -0.02 0.375 0.00788 0.48 0.3198 0.672 1231829 Bionet1_000105 CC(C)Nc1nc(nc(c1C#N)c2ccc(Cl)cc2)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B08 compound treatment 0.378 0.00155 0.08 0.367 -1.25E-4 -0.01 0.0506 0.6368 1489554 Bionet1_000106 Clc1cccc(Cl)c1Cn2cc(NC(=O)OCC#C)ccc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B09 compound treatment 0.372 -0.00445 -0.23 0.374 0.00688 0.42 0.1325 0.28 1907856 Bionet1_000107 CCN(CC)c1nc(nc(c1C#N)c2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B10 compound treatment 0.356 -0.0205 -1.05 0.36 -0.00712 -0.43 -1.0436 -0.9229 1439159 Bionet1_000108 CC(C)(C)NC(=O)Nc1ccc(=O)n(Cc2c(Cl)cccc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B11 compound treatment 0.37 -0.00645 -0.33 0.372 0.00488 0.29 -0.0252 -0.0569 1369131 Bionet1_000109 CN1CCN(CC1)c2nc(nc(c2C#N)c3ccc(Cl)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B12 compound treatment 0.372 -0.00445 -0.23 0.368 8.75E-4 0.05 -0.1236 -0.529 1247971 Bionet1_000110 Clc1cccc(Cl)c1Cn2cc(ccc2=O)C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B13 compound treatment 0.369 -0.00745 -0.38 0.371 0.00388 0.23 -0.104 -0.2326 1907857 Bionet1_000111 CCN(CC)c1nc(nc(c1C#N)c2ccc(Cl)cc2)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B14 compound treatment 0.402 0.0255 1.31 0.369 0.00188 0.11 1.0038 0.7655 1555183 Bionet1_000112 Clc1cccc(Cl)c1Cn2cc(ccc2=O)C(=O)NCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B15 compound treatment 0.376 -4.52E-4 -0.02 0.37 0.00288 0.17 0.1064 0.6077 1419239 Bionet1_000113 CN1CCN(CC1)c2nc(nc(c2C#N)c3ccccc3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B16 compound treatment 0.378 0.00155 0.08 0.371 0.00388 0.23 0.2214 0.8965 1907858 Bionet1_000114 CN(C)CCCNC(=O)c1ccc(=O)n(Cc2c(Cl)cccc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B17 compound treatment 0.385 0.00855 0.44 0.367 -1.25E-4 -0.01 0.3037 0.6948 1277711 Bionet1_000115 CN1CCN(CC1)c2nc(nc(c2C#N)c3ccc(Cl)cc3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B18 compound treatment 0.378 0.00155 0.08 0.376 0.00888 0.54 0.4348 0.8029 1125710 Bionet1_000116 CCN(CC)C(=O)c1ccc(=O)n(Cc2c(Cl)cccc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B19 compound treatment 0.375 -0.00145 -0.07 0.372 0.00488 0.29 0.1556 0.5127 1561998 Bionet1_000117 CCN(CC)c1nc(nc(c1C#N)c2ccc(Cl)cc2)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B20 compound treatment 0.375 -0.00145 -0.07 0.371 0.00388 0.23 0.1129 0.4601 1221478 Bionet1_000118 Clc1cccc(Cl)c1Cn2cc(ccc2=O)C(=O)N3CCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B21 compound treatment 0.38 0.00355 0.18 0.379 0.0119 0.72 0.6352 0.859 1636764 Bionet1_000119 CN1CCN(CC1)c2nc(nc(c2C#N)c3ccc(Cl)cc3)c4ccncc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B22 compound treatment 0.37 -0.00645 -0.33 0.363 -0.00412 -0.25 -0.4093 -0.9904 1907859 Bionet1_000120 FC(F)(F)Oc1ccc(NC(=O)c2ccc(=O)n(Cc3ccccc3)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B23 positive control 0.091 -0.285 -14.6 0.088 -0.279 -16.85 -22.2358 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 B24 positive control 0.091 -0.285 -14.6 0.093 -0.274 -16.55 -22.0223 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C01 mock treatment 0.378 0.00155 0.08 0.371 0.00388 0.23 0.2214 0.8965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C02 mock treatment 0.377 5.48E-4 0.03 0.384 0.0169 1.02 0.7402 0.7263 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C03 compound treatment 0.432 0.0555 2.84 0.423 0.0559 3.37 4.3935 0.9963 1907860 Bionet1_000121 COc1cc(Br)cc(/C=N\c2cccc(c2)C(F)(F)F)c1O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C04 compound treatment 0.37 -0.00645 -0.33 0.376 0.00888 0.54 0.1456 0.2314 1907861 Bionet1_000122 FC(F)(F)c1nc2oc3ccccc3c(=O)c2cc1C(=O)NCc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C05 compound treatment 0.379 0.00255 0.13 0.373 0.00588 0.35 0.3429 0.9076 1907862 Bionet1_000123 CCOC(=O)COc1c(OC)cc(Br)cc1/C=N\c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C06 compound treatment 0.377 5.48E-4 0.03 0.371 0.00388 0.23 0.1852 0.7862 1907863 Bionet1_000124 [O-][N+](=O)c1cc(/C=N/OC(=O)c2ccccc2)ccc1Oc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C07 compound treatment 0.403 0.0265 1.36 0.392 0.0249 1.5 2.0217 0.9987 1664470 Bionet1_000125 NC(=O)Cn1nnc(n1)N(Cc2ccc(Cl)cc2)Cc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C08 compound treatment 0.383 0.00655 0.33 0.376 0.00888 0.54 0.6156 0.9744 1907864 Bionet1_000126 [O-][N+](=O)c1cc(/C=N/OC(=O)c2ccccc2)ccc1Oc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C09 compound treatment 0.39 0.0135 0.69 0.374 0.00688 0.42 0.7833 0.97 1907865 Bionet1_000127 CO/N=C\C(/C=C/c1ccccc1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C10 compound treatment 0.371 -0.00545 -0.28 0.367 -1.25E-4 -0.01 -0.2024 -0.726 1672129 Bionet1_000128 CN1CCN(CC1)c2ccc(cc2)c3ccnn3C(=O)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C11 compound treatment 0.367 -0.00945 -0.48 0.368 8.75E-4 0.05 -0.3044 -0.6261 1907866 Bionet1_000129 CN(NC(=O)Nc1cccc(c1)C(F)(F)F)c2c(Cl)c(Cl)nn2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C12 compound treatment 0.388 0.0115 0.59 0.373 0.00588 0.35 0.6683 0.9703 1907867 Bionet1_000130 Clc1ccc(N/C=C/2\C(=O)N(CS2(=O)=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C13 compound treatment 0.381 0.00455 0.23 0.368 8.75E-4 0.05 0.2018 0.8462 1907868 Bionet1_000131 COC(=O)c1sccc1NC(=O)c2cn(nc2C)C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C14 compound treatment 0.382 0.00555 0.28 0.372 0.00488 0.29 0.4087 0.9998 1907869 Bionet1_000132 Clc1ccc(N/C=C/2\C(=O)N(CS2=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C15 compound treatment 0.388 0.0115 0.59 0.381 0.0139 0.84 1.0098 0.9854 1907870 Bionet1_000133 O=C/1NN=C(\C1=C\Nc2ccc(Oc3ccccc3)cc2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C16 compound treatment 0.38 0.00355 0.18 0.362 -0.00512 -0.31 -0.0905 -0.2523 1907871 Bionet1_000134 COc1ccc(N/C=C/2\C(=O)N(CS2(=O)=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C17 compound treatment 0.385 0.00855 0.44 0.369 0.00188 0.11 0.3891 0.8618 1907872 Bionet1_000135 FC(F)(F)C/1=NN(C(=O)\C1=C/Nc2ccccc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C18 compound treatment 0.378 0.00155 0.08 0.364 -0.00312 -0.19 -0.0774 -0.3784 1907873 Bionet1_000136 FC(F)(F)c1cccc(NC(=O)N2CCSc3cc(Cl)ccc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C19 compound treatment 0.378 0.00155 0.08 0.373 0.00588 0.35 0.3068 0.8442 1907874 Bionet1_000137 FC(F)(F)C/1=NN(C(=O)\C1=C/Nc2cccc(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C20 compound treatment 0.365 -0.0115 -0.59 0.362 -0.00512 -0.31 -0.6328 -0.9555 1335060 Bionet1_000138 Clc1ccc(cc1)S(=O)(=O)N2CCSc3cc(Cl)ccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C21 compound treatment 0.374 -0.00245 -0.13 0.374 0.00688 0.42 0.2048 0.4725 1907875 Bionet1_000139 FC(F)(F)C/1=NN(C(=O)\C1=C/Nc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C22 compound treatment 0.371 -0.00545 -0.28 0.365 -0.00212 -0.13 -0.2878 -0.938 1682580 Bionet1_000140 COc1ccc(cc1)S(=O)(=O)N2CCSc3cc(Cl)ccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C23 positive control 0.087 -0.289 -14.8 0.085 -0.282 -17.03 -22.5085 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 C24 positive control 0.091 -0.285 -14.6 0.09 -0.277 -16.73 -22.1504 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D01 mock treatment 0.374 -0.00245 -0.13 0.355 -0.0121 -0.73 -0.6062 -0.8163 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D02 mock treatment 0.366 -0.0105 -0.53 0.366 -0.00112 -0.07 -0.4259 -0.7906 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D03 compound treatment 0.366 -0.0105 -0.53 0.361 -0.00612 -0.37 -0.6393 -0.9838 1312830 Bionet1_000141 CN1CCN(CC1)c2nc(nc(c2C#N)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D04 compound treatment 0.377 5.48E-4 0.03 0.378 0.0109 0.66 0.484 0.7366 1907876 Bionet1_000142 FC(F)(F)c1cccc(c1)C2OCC3(CO2)CSc4ccccc4C3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D05 compound treatment 0.368 -0.00845 -0.43 0.368 8.75E-4 0.05 -0.2682 -0.6161 1907877 Bionet1_000143 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NOCC#C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D06 compound treatment 0.376 -4.52E-4 -0.02 0.374 0.00688 0.42 0.2771 0.6667 1907878 Bionet1_000144 FC(F)(F)c1cccc(Oc2nnc(Cc3ccccc3)c4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D07 compound treatment 0.365 -0.0115 -0.59 0.355 -0.0121 -0.73 -0.9316 -0.9939 1907879 Bionet1_000145 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NOCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D08 compound treatment 0.372 -0.00445 -0.23 0.372 0.00488 0.29 0.0471 0.1267 1514069 Bionet1_000146 Clc1ccc(CSc2nnc(Cc3ccccc3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D09 compound treatment 0.357 -0.0195 -0.99 0.362 -0.00512 -0.31 -0.9221 -0.8852 1907880 Bionet1_000147 Clc1ccc(cc1)c2ncc(s2)C(=O)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D10 compound treatment 0.374 -0.00245 -0.13 0.387 0.0199 1.2 0.7598 0.6298 1430963 Bionet1_000148 Clc1ccc(Cn2cccc(C(=O)Nc3ccccc3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D11 compound treatment 0.385 0.00855 0.44 0.39 0.0229 1.38 1.2855 0.8875 1596601 Bionet1_000149 Brc1ccc(cc1)C(=O)c2cnc(Nc3ccccc3)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D12 compound treatment 0.376 -4.52E-4 -0.02 0.376 0.00888 0.54 0.3625 0.676 1423401 Bionet1_000150 Clc1ccc(Cn2cccc(C(=O)NCc3ccccc3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D13 compound treatment 0.359 -0.0175 -0.89 0.36 -0.00712 -0.43 -0.9351 -0.944 1907881 Bionet1_000151 Clc1ccc(cc1)c2ncc(s2)C(=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D14 compound treatment 0.37 -0.00645 -0.33 0.359 -0.00812 -0.49 -0.5801 -0.9814 1477014 Bionet1_000152 Clc1ccc(Cn2cccc(C(=O)N3CCOCC3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D15 compound treatment 0.365 -0.0115 -0.59 0.365 -0.00212 -0.13 -0.5048 -0.842 1907882 Bionet1_000153 Clc1ccc(cc1)c2ncc(s2)C(=O)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D16 compound treatment 0.364 -0.0125 -0.64 0.354 -0.0131 -0.79 -1.0105 -0.9941 1128049 Bionet1_000154 Clc1cccc(Cl)c1Cn2cccc(C(=O)Nc3ccccc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D17 compound treatment 0.367 -0.00945 -0.48 0.36 -0.00712 -0.43 -0.6459 -0.9983 1531507 Bionet1_000155 Clc1ccc(cc1)c2ncc(s2)C(=O)c3ccc(cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D18 compound treatment 0.353 -0.0235 -1.2 0.359 -0.00812 -0.49 -1.1947 -0.9222 1584601 Bionet1_000156 Clc1cccc(Cl)c1Cn2cccc(C(=O)NCc3ccccc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D19 compound treatment 0.359 -0.0175 -0.89 0.359 -0.00812 -0.49 -0.9778 -0.9603 1740551 Bionet1_000157 O=C(c1cnc(Nc2ccccc2)s1)c3ccc(cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D20 compound treatment 0.366 -0.0105 -0.53 0.357 -0.0101 -0.61 -0.8101 -0.9978 1907883 Bionet1_000158 FC(F)(F)c1cccc(Cn2cccc(C(=O)Nc3ccccc3)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D21 compound treatment 0.41 0.0335 1.72 0.413 0.0459 2.77 3.1712 0.9735 1907884 Bionet1_000159 Clc1ccc(C(=O)c2cnc(Nc3ccccc3Cl)s2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D22 compound treatment 0.368 -0.00845 -0.43 0.357 -0.0101 -0.61 -0.7378 -0.9856 1907885 Bionet1_000160 Clc1ccc(NC(=O)c2cccn(Cc3cccc(Cl)c3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D23 positive control 0.087 -0.289 -14.8 0.086 -0.281 -16.97 -22.4658 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 D24 positive control 0.092 -0.284 -14.54 0.092 -0.275 -16.61 -22.0289 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E01 mock treatment 0.379 0.00255 0.13 0.365 -0.00212 -0.13 0.0014 0.0078 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E02 mock treatment 0.377 5.48E-4 0.03 0.372 0.00488 0.29 0.2279 0.771 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E03 compound treatment 0.415 0.0385 1.97 0.383 0.0159 0.96 2.0714 0.9451 1907886 Bionet1_000161 FC(F)(F)C/1=NN(C(=O)\C1=C/Nc2cccc(c2)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E04 compound treatment 0.358 -0.0185 -0.94 0.377 0.00988 0.6 -0.2456 -0.2201 1907887 Bionet1_000162 Clc1cccc(Cl)c1CSc2nc3nccc(c4ccccc4)n3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E05 compound treatment 0.377 5.48E-4 0.03 0.372 0.00488 0.29 0.2279 0.771 1907888 Bionet1_000163 FC(F)(F)C/1=NN(C(=O)\C1=C/Nc2ccc(cc2)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E06 compound treatment 0.37 -0.00645 -0.33 0.36 -0.00712 -0.43 -0.5374 -0.9914 1907889 Bionet1_000164 Clc1cccc(Cl)c1CSc2nc3nccc(c4ccccn4)n3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E07 compound treatment 0.358 -0.0185 -0.94 0.372 0.00488 0.29 -0.459 -0.4645 1177978 Bionet1_000165 O=S(=O)(c1ccccc1)n2cc(c(n2)N3CCOCC3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E08 compound treatment 0.36 -0.0165 -0.84 0.373 0.00588 0.35 -0.344 -0.3769 1907890 Bionet1_000166 Clc1ccc(/C=C/c2nc3ccccc3c(=O)n2c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E09 compound treatment 0.381 0.00455 0.23 0.377 0.00988 0.6 0.586 0.9157 1907891 Bionet1_000167 CN(C)c1nn(cc1c2ccccc2)C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E10 compound treatment 0.396 0.0195 1.0 0.392 0.0249 1.5 1.7686 0.9804 1907892 Bionet1_000168 COc1ccc(/C=C/c2nc3ccccc3c(=O)n2c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E11 compound treatment 0.415 0.0385 1.97 0.395 0.0279 1.68 2.5837 0.9969 1907893 Bionet1_000169 CN(C)c1nn(cc1c2ccccc2)C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E12 compound treatment 0.387 0.0105 0.54 0.361 -0.00612 -0.37 0.1199 0.1834 1907894 Bionet1_000170 COc1cccc(/C=C/c2nc3ccccc3c(=O)n2c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E13 compound treatment 0.419 0.0425 2.18 0.403 0.0359 2.17 3.0698 1.0 1907895 Bionet1_000171 CN(C)c1nn(cc1c2ccccc2)C(=S)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E14 compound treatment 0.444 0.0675 3.45 0.428 0.0609 3.67 5.0408 0.9995 1907896 Bionet1_000172 CNc1nn(cc1[N+](=O)[O-])S(=O)(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E15 compound treatment 0.432 0.0555 2.84 0.421 0.0539 3.25 4.3082 0.9977 1907897 Bionet1_000173 CN(C)c1nn(cc1c2ccccc2)C(=S)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E16 compound treatment 0.369 -0.00745 -0.38 0.368 8.75E-4 0.05 -0.2321 -0.6033 1198543 Bionet1_000174 Cc1nc2oc3ccccc3c(=O)c2cc1C(=O)NCc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E17 compound treatment 0.386 0.00955 0.49 0.374 0.00688 0.42 0.6387 0.9967 1907898 Bionet1_000175 COC(Cc1nnc(SCc2ccccc2)n1c3ccccc3)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E18 compound treatment 0.369 -0.00745 -0.38 0.371 0.00388 0.23 -0.104 -0.2326 1907899 Bionet1_000176 FC(F)(F)c1cccc(NC(=O)Cc2nc(=O)c3ccccc3s2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E19 compound treatment 0.368 -0.00845 -0.43 0.371 0.00388 0.23 -0.1402 -0.2852 1907900 Bionet1_000177 COC(Cc1nnc(SCc2ccccc2)n1c3ccc(Cl)cc3)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E20 compound treatment 0.371 -0.00545 -0.28 0.372 0.00488 0.29 0.011 0.0271 1655354 Bionet1_000178 CSc1nc2nccc(C(C)Oc3ccc(Cl)cc3Cl)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E21 compound treatment 0.376 -4.52E-4 -0.02 0.376 0.00888 0.54 0.3625 0.676 1907901 Bionet1_000179 COC(Cc1nnc(SCC#C)n1c2cccc(c2)C(F)(F)F)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E22 compound treatment 0.376 -4.52E-4 -0.02 0.368 8.75E-4 0.05 0.021 0.3647 1907902 Bionet1_000180 CN(C)/C=C(/C(=O)c1ccc(Cl)cc1)\S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E23 positive control 0.089 -0.287 -14.7 0.086 -0.281 -16.97 -22.3935 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 E24 positive control 0.097 -0.279 -14.29 0.091 -0.276 -16.67 -21.8908 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F01 mock treatment 0.379 0.00255 0.13 0.367 -1.25E-4 -0.01 0.0868 0.665 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F02 mock treatment 0.378 0.00155 0.08 0.371 0.00388 0.23 0.2214 0.8965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F03 compound treatment 0.409 0.0325 1.66 0.437 0.0699 4.22 4.1596 0.9173 1443658 Bionet1_000181 Clc1ccccc1Nc2ncc(s2)C(=O)c3ccc(cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F04 compound treatment 0.391 0.0145 0.74 0.392 0.0249 1.5 1.5878 0.9475 1907903 Bionet1_000182 Fc1ccc(NC(=O)c2cccn(Cc3cccc(Cl)c3)c2=O)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F05 compound treatment 0.404 0.0275 1.41 0.416 0.0489 2.95 3.0824 0.9428 1907904 Bionet1_000183 Clc1ccccc1Nc2ncc(s2)C(=O)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F06 compound treatment 0.38 0.00355 0.18 0.373 0.00588 0.35 0.3791 0.9516 1907905 Bionet1_000184 CN(C)CCNC(=O)c1cccn(Cc2cccc(c2)C(F)(F)F)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F07 compound treatment 0.37 -0.00645 -0.33 0.382 0.0149 0.9 0.4017 0.4199 1265704 Bionet1_000185 Clc1ccc(cc1Cl)C(=O)c2cnc(Nc3ccccc3Cl)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F08 compound treatment 0.377 5.48E-4 0.03 0.375 0.00788 0.48 0.356 0.7475 1226268 Bionet1_000186 CN(C)CCNC(=O)c1cccn(Cc2c(Cl)cccc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F09 compound treatment 0.387 0.0105 0.54 0.397 0.0299 1.8 1.6567 0.8801 1313674 Bionet1_000187 Fc1ccc(cc1)C(=O)c2cnc(Nc3ccc(Cl)c(Cl)c3)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F10 compound treatment 0.37 -0.00645 -0.33 0.372 0.00488 0.29 -0.0252 -0.0569 1321594 Bionet1_000188 CN1CCN(CC1)C(=O)c2cccn(Cc3c(Cl)cccc3Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F11 compound treatment 0.388 0.0115 0.59 0.397 0.0299 1.8 1.6928 0.892 1683152 Bionet1_000189 Clc1ccc(cc1)C(=O)c2cnc(Nc3ccc(Cl)c(Cl)c3)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F12 compound treatment 0.379 0.00255 0.13 0.389 0.0219 1.32 1.0259 0.7731 1907906 Bionet1_000190 FC(F)(F)c1cccc(NC(=O)c2cccn(Cc3ccccc3)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F13 compound treatment 0.393 0.0165 0.85 0.378 0.0109 0.66 1.0625 0.9921 1907907 Bionet1_000191 N#Cc1c(Sc2ccccc2)nc(nc1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F14 compound treatment 0.43 0.0535 2.74 0.426 0.0589 3.55 4.4493 0.9917 1907908 Bionet1_000192 FC(F)(F)Oc1ccc(NC(=O)c2cccn(Cc3ccccc3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F15 compound treatment 0.377 5.48E-4 0.03 0.382 0.0149 0.9 0.6548 0.7288 1907909 Bionet1_000193 NCCNC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F16 compound treatment 0.421 0.0445 2.28 0.403 0.0359 2.17 3.1421 0.9997 1254840 Bionet1_000194 Fc1ccc(NC(=O)Nc2cccn(Cc3ccc(Cl)cc3)c2=O)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F17 compound treatment 0.383 0.00655 0.33 0.405 0.0379 2.29 1.8535 0.8021 1907910 Bionet1_000195 [O-][N+](=O)c1ccc(CO/N=C/c2c(nc3sccn23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F18 compound treatment 0.396 0.0195 1.0 0.421 0.0539 3.25 3.0065 0.8836 1457322 Bionet1_000196 Cc1cccc(C)c1NC(=O)Nc2cccn(Cc3ccc(Cl)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F19 compound treatment 0.368 -0.00845 -0.43 0.377 0.00988 0.6 0.116 0.1575 1907911 Bionet1_000197 COc1ccc(cc1)C(=O)O/N=C/c2c(nc3sccn23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F20 compound treatment 0.406 0.0295 1.51 0.39 0.0229 1.38 2.0448 0.999 1216393 Bionet1_000198 Cc1ccc(NC(=O)Nc2cccn(Cc3ccc(Cl)cc3)c2=O)nc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F21 compound treatment 0.374 -0.00245 -0.13 0.381 0.0139 0.84 0.5036 0.5947 1907912 Bionet1_000199 Clc1ccc(NC(=O)C(=O)NN/C=C/2\OC(=O)c3ccccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F22 compound treatment 0.371 -0.00545 -0.28 0.381 0.0139 0.84 0.3952 0.4476 1191923 Bionet1_000200 CN1CCN(CC1)C(=O)Nc2cccn(Cc3ccc(Cl)c(Cl)c3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F23 positive control 0.088 -0.288 -14.75 0.089 -0.278 -16.79 -22.3016 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 F24 positive control 0.094 -0.282 -14.44 0.093 -0.274 -16.55 -21.9139 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G01 mock treatment 0.375 -0.00145 -0.07 0.356 -0.0111 -0.67 -0.5274 -0.7805 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G02 mock treatment 0.367 -0.00945 -0.48 0.368 8.75E-4 0.05 -0.3044 -0.6261 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G03 compound treatment 0.392 0.0155 0.8 0.407 0.0399 2.41 2.2643 0.8932 1907913 Bionet1_000201 FC(F)(F)c1cccc(N/C=C/c2onc(c2C#N)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G04 compound treatment 0.379 0.00255 0.13 0.377 0.00988 0.6 0.5137 0.8418 1907914 Bionet1_000202 Nc1ncc(c(n1)c2ccc(Cl)cc2)S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G05 compound treatment 0.421 0.0445 2.28 0.437 0.0699 4.22 4.5934 0.9582 1907915 Bionet1_000203 Cc1ccc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G06 compound treatment 0.366 -0.0105 -0.53 0.366 -0.00112 -0.07 -0.4259 -0.7906 1907916 Bionet1_000204 CN(C)/C=C(/C(=O)c1ccc(Cl)cc1)\S(=O)(=O)c2ccc(C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G07 compound treatment 0.409 0.0325 1.66 0.422 0.0549 3.31 3.5193 0.9493 1907917 Bionet1_000205 Clc1ccc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G08 compound treatment 0.376 -4.52E-4 -0.02 0.376 0.00888 0.54 0.3625 0.676 1907918 Bionet1_000206 Cc1ccc(cc1)S(=O)(=O)c2cnc(N)nc2c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G09 compound treatment 0.436 0.0595 3.04 0.424 0.0569 3.43 4.5808 0.9982 1907919 Bionet1_000207 COc1ccc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G10 compound treatment 0.369 -0.00745 -0.38 0.365 -0.00212 -0.13 -0.3601 -0.8958 1351582 Bionet1_000208 Cc1ccc2oc3nc(C)c(cc3c(=O)c2c1)C(=O)NCc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G11 compound treatment 0.446 0.0695 3.56 0.44 0.0729 4.4 5.6254 0.9944 1907920 Bionet1_000209 COc1ccc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)c(OC)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G12 compound treatment 0.371 -0.00545 -0.28 0.372 0.00488 0.29 0.011 0.0271 1161021 Bionet1_000210 Brc1ccc(cc1)c2ccnc3nc(nn23)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G13 compound treatment 0.401 0.0245 1.26 0.386 0.0189 1.14 1.6933 0.9988 1907921 Bionet1_000211 Clc1cc(Cl)cc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G14 compound treatment 0.388 0.0115 0.59 0.37 0.00288 0.17 0.5403 0.8778 1597676 Bionet1_000212 C1CN(CCO1)c2nc3nccc(c4ccc(cc4)c5ccccc5)n3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G15 compound treatment 0.446 0.0695 3.56 0.421 0.0539 3.25 4.8143 0.999 1907922 Bionet1_000213 Clc1cccc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G16 compound treatment 0.367 -0.00945 -0.48 0.372 0.00488 0.29 -0.1336 -0.2362 1377034 Bionet1_000214 Clc1ccc(c(Cl)c1)c2ccnc3nc(nn23)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G17 compound treatment 0.444 0.0675 3.45 0.448 0.0809 4.88 5.8946 0.9856 1907923 Bionet1_000215 Clc1cccc(Cl)c1c2noc(/C=C/Nc3ccccc3)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G18 compound treatment 0.382 0.00555 0.28 0.376 0.00888 0.54 0.5795 0.9558 1589535 Bionet1_000216 C1CN(CCO1)c2nc3nccc(c4ccc(Oc5ccccc5)cc4)n3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G19 compound treatment 0.393 0.0165 0.85 0.381 0.0139 0.84 1.1906 1.0 1907924 Bionet1_000217 Clc1ccc(N/C=C/c2onc(c2C#N)c3c(Cl)cccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G20 compound treatment 0.373 -0.00345 -0.18 0.374 0.00688 0.42 0.1687 0.374 1505175 Bionet1_000218 Clc1ccc(NC(=O)N2CCN(CC2)c3cccc(Cl)n3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G21 compound treatment 0.396 0.0195 1.0 0.393 0.0259 1.56 1.8113 0.9767 1907925 Bionet1_000219 Fc1ccc(N/C=C/c2onc(c2C#N)c3c(Cl)cccc3Cl)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G22 compound treatment 0.367 -0.00945 -0.48 0.368 8.75E-4 0.05 -0.3044 -0.6261 1263635 Bionet1_000220 Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3cccc(Cl)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G23 positive control 0.089 -0.287 -14.7 0.088 -0.279 -16.85 -22.3081 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 G24 positive control 0.094 -0.282 -14.44 0.093 -0.274 -16.55 -21.9139 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H01 mock treatment 0.386 0.00955 0.49 0.37 0.00288 0.17 0.468 0.9031 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H02 mock treatment 0.382 0.00555 0.28 0.378 0.0109 0.66 0.6648 0.9296 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H03 compound treatment 0.375 -0.00145 -0.07 0.347 -0.0201 -1.21 -0.9116 -0.7489 1907926 Bionet1_000221 Clc1ccc(cc1)C(=O)C/C=N/OCc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H04 compound treatment 0.386 0.00955 0.49 0.397 0.0299 1.8 1.6205 0.8673 1563074 Bionet1_000222 Clc1ccc(Cn2cccc(NC(=O)OCC#C)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H05 compound treatment 0.389 0.0125 0.64 0.399 0.0319 1.92 1.8143 0.8945 1907927 Bionet1_000223 Clc1ccc(CO/N=C/NC(=O)/C(=C/c2cccs2)/C#N)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H06 compound treatment 0.381 0.00455 0.23 0.363 -0.00412 -0.25 -0.0116 -0.0341 1907928 Bionet1_000224 FC(F)(F)c1cccc(CNC(=O)c2cccn(Cc3ccccc3)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H07 compound treatment 0.379 0.00255 0.13 0.369 0.00188 0.11 0.1722 0.9975 1907929 Bionet1_000225 COc1ccc(cc1)C(=O)C/C=N/OCc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H08 compound treatment 0.368 -0.00845 -0.43 0.372 0.00488 0.29 -0.0975 -0.1864 1724228 Bionet1_000226 Clc1ccc(Cn2cc(ccc2=O)C(=O)NCCN3CCOCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H09 compound treatment 0.377 5.48E-4 0.03 0.376 0.00888 0.54 0.3987 0.7431 1907930 Bionet1_000227 Clc1ccc(CO/N=C/NC(=O)/C(=C\c2ccccc2)/C#N)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H10 compound treatment 0.382 0.00555 0.28 0.376 0.00888 0.54 0.5795 0.9558 1907931 Bionet1_000228 FC(F)(F)COC(=O)Nc1cccn(Cc2ccc(Cl)c(Cl)c2)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H11 compound treatment 0.389 0.0125 0.64 0.371 0.00388 0.23 0.6191 0.9065 1907932 Bionet1_000229 Clc1cccc(Cl)c1CO/N=C/NC(=O)/C(=C\c2ccccc2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H12 compound treatment 0.369 -0.00745 -0.38 0.368 8.75E-4 0.05 -0.2321 -0.6033 1342989 Bionet1_000230 Clc1ccc(Cn2cccc(NC(=O)Oc3cccnc3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H13 compound treatment 0.402 0.0255 1.31 0.388 0.0209 1.26 1.8148 0.9998 1907933 Bionet1_000231 Clc1ccc(CO/N=C/NC(=O)/C(=C\c2ccccc2)/C#N)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H14 compound treatment 0.394 0.0175 0.9 0.372 0.00488 0.29 0.8426 0.8923 1907934 Bionet1_000232 [O-][N+](=O)c1cc(cn(Cc2ccc(Cl)c(Cl)c2)c1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H15 compound treatment 0.397 0.0205 1.05 0.385 0.0179 1.08 1.506 0.9999 1907935 Bionet1_000233 Clc1ccc(cc1)C(=O)C/C=N/OCc2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H16 compound treatment 0.377 5.48E-4 0.03 0.375 0.00788 0.48 0.356 0.7475 1469293 Bionet1_000234 Oc1ccc2cc(NC(=O)c3ccc(Cl)cc3Cl)c(=O)oc2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H17 compound treatment 0.383 0.00655 0.33 0.389 0.0219 1.32 1.1705 0.8592 1907936 Bionet1_000235 O/N=C/c1c(SCc2cccc(c2)C(F)(F)F)nc3sccn13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H18 compound treatment 0.364 -0.0125 -0.64 0.361 -0.00612 -0.37 -0.7117 -0.9666 1641579 Bionet1_000236 COc1ccc2cc(NC(=O)c3ccc(Cl)cc3Cl)c(=O)oc2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H19 compound treatment 0.368 -0.00845 -0.43 0.376 0.00888 0.54 0.0733 0.1064 1907937 Bionet1_000237 Clc1ccc(Sc2nc(nc(c2C#N)c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H20 compound treatment 0.389 0.0125 0.64 0.368 8.75E-4 0.05 0.4911 0.7627 1713813 Bionet1_000238 Clc1ccc(Cn2cccc(C(=O)Nc3nccs3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H21 compound treatment 0.374 -0.00245 -0.13 0.375 0.00788 0.48 0.2475 0.5034 1907938 Bionet1_000239 Clc1ccc(cc1)c2nc(nc(Sc3ccccc3)c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H22 compound treatment 0.375 -0.00145 -0.07 0.367 -1.25E-4 -0.01 -0.0578 -0.775 1679759 Bionet1_000240 Clc1ccc(Cn2cccc(C(=O)Nc3cccnc3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H23 positive control 0.091 -0.285 -14.6 0.087 -0.28 -16.91 -22.2785 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 H24 positive control 0.1 -0.276 -14.14 0.094 -0.273 -16.49 -21.6542 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I01 mock treatment 0.379 0.00255 0.13 0.367 -1.25E-4 -0.01 0.0868 0.665 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I02 mock treatment 0.377 5.48E-4 0.03 0.373 0.00588 0.35 0.2706 0.7606 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I03 compound treatment 0.504 0.128 6.52 0.519 0.152 9.17 11.0947 0.9861 1907939 Bionet1_000241 COc1ccccc1N/C=C/c2onc(c2C#N)c3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I04 compound treatment 0.378 0.00155 0.08 0.379 0.0119 0.72 0.5629 0.7805 1180025 Bionet1_000242 C1CN(CCN1C(c2ccccc2)c3ccccc3)c4cnc5ccccc5n4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I05 compound treatment 0.454 0.0775 3.97 0.489 0.122 7.36 8.0063 0.9579 1907940 Bionet1_000243 COc1ccc(N/C=C/c2onc(c2C#N)c3c(Cl)cccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I06 compound treatment 0.362 -0.0145 -0.74 0.368 8.75E-4 0.05 -0.4852 -0.6549 1708400 Bionet1_000244 Nc1c(cnc2nc(nn12)N3CCN(CC3)c4ccccc4)c5ccc(F)cc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I07 compound treatment 0.435 0.0585 2.99 0.442 0.0749 4.52 5.3131 0.98 1907941 Bionet1_000245 Cc1ccc(N/C=C/c2onc(c2C#N)c3c(Cl)cccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I08 compound treatment 0.361 -0.0155 -0.79 0.374 0.00688 0.42 -0.2652 -0.2972 1472356 Bionet1_000246 Cc1nc2oc3ccc(F)cc3c(=O)c2cc1C(=O)Nc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I09 compound treatment 0.394 0.0175 0.9 0.393 0.0259 1.56 1.739 0.9654 1907942 Bionet1_000247 Fc1cccc(Cl)c1c2noc(/C=C/Nc3ccc(Cl)cc3)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I10 compound treatment 0.355 -0.0215 -1.1 0.373 0.00588 0.35 -0.5248 -0.4553 1558634 Bionet1_000248 Cc1nc2oc3ccc(F)cc3c(=O)c2cc1C(=O)NCc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I11 compound treatment 0.475 0.0985 5.04 0.466 0.0989 5.97 7.7838 0.9965 1907943 Bionet1_000249 COc1cccc(N/C=C/c2onc(c2C#N)c3c(F)cccc3Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I12 compound treatment 0.374 -0.00245 -0.13 0.367 -1.25E-4 -0.01 -0.094 -0.7483 1233178 Bionet1_000250 Cc1nc2oc3ccc(F)cc3c(=O)c2cc1C(=O)NCc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I13 compound treatment 0.468 0.0915 4.68 0.471 0.104 6.27 7.7441 0.9896 1907944 Bionet1_000251 COC(=O)c1c(/C=C/Nc2ccccc2)onc1c3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I14 compound treatment 0.397 0.0205 1.05 0.384 0.0169 1.02 1.4633 0.9999 1907945 Bionet1_000252 FC(F)(F)c1cccc(CS(=O)(=O)c2cnc3ccccc3n2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I15 compound treatment 0.423 0.0465 2.38 0.453 0.0859 5.18 5.3487 0.9377 1907946 Bionet1_000253 CNC1=C(CC(=C(N1C)N2CCN(CC2)S(=O)(=O)C)[N+](=O)[O-])[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I16 compound treatment 0.375 -0.00145 -0.07 0.37 0.00288 0.17 0.0702 0.3721 1119661 Bionet1_000254 CC(Oc1ccc(Cl)cc1)c2ccnn2S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I17 compound treatment 0.369 -0.00745 -0.38 0.376 0.00888 0.54 0.1094 0.1664 1907947 Bionet1_000255 CN(C)S(=O)(=O)c1ccc(N/C=C/2\C(=O)NN=C2C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I18 compound treatment 0.375 -0.00145 -0.07 0.358 -0.00912 -0.55 -0.442 -0.7952 1651727 Bionet1_000256 Cc1nc2oc3ccc(Cl)cc3c(=O)c2cc1C(=O)Nc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I19 compound treatment 0.355 -0.0215 -1.1 0.367 -1.25E-4 -0.01 -0.7809 -0.712 1907948 Bionet1_000257 CN(C)S(=O)(=O)c1ccc(N/C=C/2\C(=O)N(C)N=C2C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I20 compound treatment 0.363 -0.0135 -0.69 0.364 -0.00312 -0.19 -0.6198 -0.869 1218761 Bionet1_000258 Cc1nc2oc3ccc(Cl)cc3c(=O)c2cc1C(=O)NCc4ccncc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I21 compound treatment 0.398 0.0215 1.1 0.392 0.0249 1.5 1.8409 0.9884 1907949 Bionet1_000259 CN(C)S(=O)(=O)c1ccc(N/C=C/2\C(=O)NN=C2c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I22 compound treatment 0.378 0.00155 0.08 0.371 0.00388 0.23 0.2214 0.8965 1347908 Bionet1_000260 Cc1nc2oc3ccc(Cl)cc3c(=O)c2cc1C(=O)Nc4ccncc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I23 positive control 0.094 -0.282 -14.44 0.089 -0.278 -16.79 -22.0846 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 I24 positive control 0.098 -0.278 -14.24 0.094 -0.273 -16.49 -21.7266 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J01 mock treatment 0.381 0.00455 0.23 0.367 -1.25E-4 -0.01 0.1591 0.6838 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J02 mock treatment 0.384 0.00755 0.39 0.373 0.00588 0.35 0.5237 0.9991 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J03 compound treatment 0.382 0.00555 0.28 0.37 0.00288 0.17 0.3233 0.9722 1907950 Bionet1_000261 COc1ccc(cc1)c2nc(nc(N3CCOCC3)c2C#N)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J04 compound treatment 0.38 0.00355 0.18 0.387 0.0199 1.2 0.9767 0.8049 1371363 Bionet1_000262 Clc1ccc(Cn2cccc(C(=O)Nc3nncs3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J05 compound treatment 0.382 0.00555 0.28 0.388 0.0209 1.26 1.0917 0.8451 1405736 Bionet1_000263 COc1ccc(cc1)c2nc(nc(N3CCN(C)CC3)c2C#N)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J06 compound treatment 0.393 0.0165 0.85 0.395 0.0279 1.68 1.7882 0.9494 1641405 Bionet1_000264 Clc1ccc(Cn2cccc(C(=O)Nc3ccccn3)c2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J07 compound treatment 0.371 -0.00545 -0.28 0.375 0.00788 0.48 0.1391 0.2523 1176722 Bionet1_000265 COc1ccc(cc1)c2nc(nc(N3CCOCC3)c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J08 compound treatment 0.371 -0.00545 -0.28 0.376 0.00888 0.54 0.1817 0.3009 1738446 Bionet1_000266 CN(C)CCNC(=O)c1cccn(Cc2ccc(Cl)c(Cl)c2)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J09 compound treatment 0.373 -0.00345 -0.18 0.382 0.0149 0.9 0.5102 0.5575 1276454 Bionet1_000267 COc1ccc(cc1)c2nc(nc(N3CCN(C)CC3)c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J10 compound treatment 0.367 -0.00945 -0.48 0.377 0.00988 0.6 0.0798 0.104 1907951 Bionet1_000268 COc1ccc2cc(NC(=O)c3cccc(c3)C(F)(F)F)c(=O)oc2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J11 compound treatment 0.377 5.48E-4 0.03 0.369 0.00188 0.11 0.0999 0.8564 1608299 Bionet1_000269 CCN(CC)c1nc(nc(c1C#N)c2ccc(OC)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J12 compound treatment 0.361 -0.0155 -0.79 0.396 0.0289 1.74 0.6739 0.3521 1599052 Bionet1_000270 CN(C)CCNC(=O)c1ccc(=O)n(Cc2c(Cl)cccc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J13 compound treatment 0.382 0.00555 0.28 0.365 -0.00212 -0.13 0.1099 0.353 1907952 Bionet1_000271 COc1ccc(cc1)c2nc(nc(Sc3ccccc3)c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J14 compound treatment 0.384 0.00755 0.39 0.375 0.00788 0.48 0.6091 0.9947 1286465 Bionet1_000272 Clc1cccc(Cn2cccc(C(=O)NCc3ccccc3)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J15 compound treatment 0.368 -0.00845 -0.43 0.367 -1.25E-4 -0.01 -0.3109 -0.7193 1907953 Bionet1_000273 Clc1ccc(cc1)C(=O)O/N=C/c2c(nc3sccn23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J16 compound treatment 0.373 -0.00345 -0.18 0.375 0.00788 0.48 0.2114 0.4168 1432531 Bionet1_000274 CCN(CC)C(=O)c1cc(Cl)c(=O)n(Cc2ccc(Cl)c(Cl)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J17 compound treatment 0.375 -0.00145 -0.07 0.364 -0.00312 -0.19 -0.1859 -0.9169 1529897 Bionet1_000275 CCOC(=O)c1cc(NC(=O)c2ccc(Cl)cc2)c(=O)oc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J18 compound treatment 0.368 -0.00845 -0.43 0.371 0.00388 0.23 -0.1402 -0.2852 1628795 Bionet1_000276 Clc1ccc(Cn2cc(cc(Cl)c2=O)C(=O)NCC=C)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J19 compound treatment 0.407 0.0305 1.56 0.415 0.0479 2.89 3.1481 0.9583 1907954 Bionet1_000277 CN(C)/C=C/c1oc(=O)c(NC(=O)c2ccc(Cl)cc2)cc1C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J20 compound treatment 0.362 -0.0145 -0.74 0.371 0.00388 0.23 -0.3571 -0.4607 1907955 Bionet1_000278 [O-][N+](=O)c1cc(cn(Cc2c(Cl)cccc2Cl)c1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J21 compound treatment 0.376 -4.52E-4 -0.02 0.379 0.0119 0.72 0.4906 0.684 1473981 Bionet1_000279 CCOC(=O)c1cc(NC(=O)c2ccc(OC)cc2)c(=O)oc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J22 compound treatment 0.364 -0.0125 -0.64 0.369 0.00188 0.11 -0.3702 -0.5724 1664412 Bionet1_000280 Clc1cccc(Cl)c1Cn2cc(cc(Cl)c2=O)C(=O)NCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J23 positive control 0.09 -0.286 -14.65 0.106 -0.261 -15.76 -21.5036 -0.9993 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 J24 positive control 0.097 -0.279 -14.29 0.096 -0.271 -16.37 -21.6773 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K01 mock treatment 0.378 0.00155 0.08 0.366 -0.00112 -0.07 0.008 0.0763 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K02 mock treatment 0.362 -0.0145 -0.74 0.365 -0.00212 -0.13 -0.6132 -0.8176 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K03 compound treatment 0.378 0.00155 0.08 0.384 0.0169 1.02 0.7763 0.7598 1907956 Bionet1_000281 CCOC/1=NN(C(=O)\C1=C/Nc2ccc(cc2)C(=O)OC)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K04 compound treatment 0.356 -0.0205 -1.05 0.384 0.0169 1.02 -0.0191 -0.0131 1624222 Bionet1_000282 Cc1nc2oc3ccc(Cl)cc3c(=O)c2cc1C(=O)OCc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K05 compound treatment 0.358 -0.0185 -0.94 0.374 0.00688 0.42 -0.3737 -0.3625 1907957 Bionet1_000283 CCOC/1=NN(C(=O)\C1=C/Nc2cc(Cl)cc(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K06 compound treatment 0.389 0.0125 0.64 0.372 0.00488 0.29 0.6618 0.9375 1907958 Bionet1_000284 CO/N=C/c1c(Sc2cccc(c2)C(F)(F)F)nc3sccn13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K07 compound treatment 0.382 0.00555 0.28 0.399 0.0319 1.92 1.5613 0.8027 1907959 Bionet1_000285 CCOC/1=NN(C(=O)\C1=C/NCc2ccc(Cl)cc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K08 compound treatment 0.368 -0.00845 -0.43 0.375 0.00788 0.48 0.0306 0.0476 1907960 Bionet1_000286 Clc1nc2sccn2c1/C=N/OCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K09 compound treatment 0.365 -0.0115 -0.59 0.372 0.00488 0.29 -0.2059 -0.3143 1907961 Bionet1_000287 CCOC/1=NN(C(=O)\C1=C/Nc2ccc(C)c(C)c2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K10 compound treatment 0.523 0.147 7.49 0.559 0.192 11.58 13.4892 0.9778 1907962 Bionet1_000288 COc1ccc(N/N=C(/C#N)\S(=O)(=O)c2nsc(C)c2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K11 compound treatment 0.382 0.00555 0.28 0.378 0.0109 0.66 0.6648 0.9296 1907963 Bionet1_000289 CCOC/1=NN(C(=O)\C1=C/Nc2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K12 compound treatment 0.46 0.0835 4.27 0.463 0.0959 5.79 7.1134 0.9888 1907964 Bionet1_000290 Cc1snc(c1C#N)S(=O)(=O)/C(=N/Nc2cccc(c2)C(F)(F)F)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K13 compound treatment 0.365 -0.0115 -0.59 0.368 8.75E-4 0.05 -0.3767 -0.6407 1907965 Bionet1_000291 CCOC/1=NN(C(=O)\C1=C/Nc2ccc(C)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K14 compound treatment 0.524 0.148 7.54 0.532 0.165 9.95 12.3728 0.9907 1907966 Bionet1_000292 Cc1snc(c1C#N)S(=O)(=O)/C(=N/Nc2ccc(cc2)C(F)(F)F)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K15 compound treatment 0.391 0.0145 0.74 0.381 0.0139 0.84 1.1183 0.9982 1907967 Bionet1_000293 CCOC/1=NN(C(=O)\C1=C/Nc2ccc(OC)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K16 compound treatment 0.36 -0.0165 -0.84 0.368 8.75E-4 0.05 -0.5575 -0.6614 1907968 Bionet1_000294 CN(C)C(=C(C#N)C#N)N1CCN(CC1)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K17 compound treatment 0.36 -0.0165 -0.84 0.363 -0.00412 -0.25 -0.7709 -0.8787 1907969 Bionet1_000295 CCOC/1=NN(C(=O)\C1=C/NN2CCOCC2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K18 compound treatment 0.37 -0.00645 -0.33 0.368 8.75E-4 0.05 -0.1959 -0.5864 1907970 Bionet1_000296 Clc1nc2sccn2c1/C=N/OCc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K19 compound treatment 0.362 -0.0145 -0.74 0.366 -0.00112 -0.07 -0.5705 -0.7689 1907971 Bionet1_000297 CCOC/1=NN(C(=O)\C1=C/Nc2ccc(F)cc2F)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K20 compound treatment 0.357 -0.0195 -0.99 0.371 0.00388 0.23 -0.5379 -0.5264 1907972 Bionet1_000298 Clc1nc2sccn2c1/C=N/OCc3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K21 compound treatment 0.372 -0.00445 -0.23 0.368 8.75E-4 0.05 -0.1236 -0.529 1907973 Bionet1_000299 CCOC/1=NN(C(=O)\C1=C/NCc2cccnc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K22 compound treatment 0.522 0.146 7.44 0.534 0.167 10.07 12.3858 0.9889 1907974 Bionet1_000300 Cc1snc(c1C#N)S(=O)(=O)/C(=N\Nc2ccc(Cl)cc2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K23 positive control 0.091 -0.285 -14.6 0.093 -0.274 -16.55 -22.0223 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 K24 positive control 0.099 -0.277 -14.19 0.1 -0.267 -16.13 -21.4343 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L01 mock treatment 0.385 0.00855 0.44 0.367 -1.25E-4 -0.01 0.3037 0.6948 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L02 mock treatment 0.375 -0.00145 -0.07 0.375 0.00788 0.48 0.2837 0.5896 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L03 compound treatment 0.361 -0.0155 -0.79 0.375 0.00788 0.48 -0.2225 -0.2413 1684368 Bionet1_000301 COc1ccc(cc1)C(=O)Nc2cc(C(=O)c3ccccc3)c(C)oc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L04 compound treatment 0.373 -0.00345 -0.18 0.38 0.0129 0.78 0.4248 0.533 1631680 Bionet1_000302 CCN(CC)C(=O)c1cc(Cl)c(=O)n(Cc2c(Cl)cccc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L05 compound treatment 0.387 0.0105 0.54 0.384 0.0169 1.02 1.1017 0.9558 1187135 Bionet1_000303 Cc1oc(=O)c(NC(=O)c2ccc(Cl)cc2)cc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L06 compound treatment 0.375 -0.00145 -0.07 0.372 0.00488 0.29 0.1556 0.5127 1907975 Bionet1_000304 FC(F)(F)c1cccc(Cn2cc(cc(Cl)c2=O)C(=O)NCC=C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L07 compound treatment 0.407 0.0305 1.56 0.403 0.0359 2.17 2.6359 0.9871 1907976 Bionet1_000305 COc1ccc(cc1)C(=O)Nc2cc(C(=O)C)c(/C=C/N(C)C)oc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L08 compound treatment 0.361 -0.0155 -0.79 0.379 0.0119 0.72 -0.0518 -0.0485 1907977 Bionet1_000306 COC(=O)c1ccc(Cn2cc(cc([N+](=O)[O-])c2=O)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L09 compound treatment 0.362 -0.0145 -0.74 0.38 0.0129 0.78 0.0271 0.0253 1907978 Bionet1_000307 FC(F)(F)c1cccc(c1)C(=O)Nc2cc3C(=O)CCCc3oc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L10 compound treatment 0.36 -0.0165 -0.84 0.371 0.00388 0.23 -0.4294 -0.4918 1907979 Bionet1_000308 FC(F)(F)c1ccc(=O)n(Cc2ccc(cc2)C(=O)NCc3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L11 compound treatment 0.36 -0.0165 -0.84 0.376 0.00888 0.54 -0.216 -0.2166 1907980 Bionet1_000309 COc1ccc(Sc2cc(nc(n2)c3ccccn3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L12 compound treatment 0.363 -0.0135 -0.69 0.373 0.00588 0.35 -0.2356 -0.3044 1907981 Bionet1_000310 CC(C)(C)NC(=O)c1ccc(Cn2cc(ccc2=O)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L13 compound treatment 0.38 0.00355 0.18 0.368 8.75E-4 0.05 0.1656 0.8766 1907982 Bionet1_000311 FC(F)(F)c1cc(Sc2ccc(Cl)cc2)nc(n1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L14 compound treatment 0.37 -0.00645 -0.33 0.371 0.00388 0.23 -0.0679 -0.1678 1907983 Bionet1_000312 FC(F)(F)c1ccc(=O)n(Cc2ccc(cc2)C(=O)NCc3ccncc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L15 compound treatment 0.376 -4.52E-4 -0.02 0.391 0.0239 1.44 1.0028 0.6957 1907984 Bionet1_000313 FC(F)(F)c1cccc(Oc2cc(nc(n2)c3ccccn3)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L16 compound treatment 0.367 -0.00945 -0.48 0.38 0.0129 0.78 0.2079 0.2271 1907985 Bionet1_000314 FC(F)(F)c1ccc(=O)n(Cc2ccc(cc2)C(=O)NCC3CC3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L17 compound treatment 0.367 -0.00945 -0.48 0.38 0.0129 0.78 0.2079 0.2271 1907986 Bionet1_000315 FC(F)(F)c1cc(Oc2ccc(Cl)cc2)nc(n1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L18 compound treatment 0.37 -0.00645 -0.33 0.38 0.0129 0.78 0.3163 0.3746 1907987 Bionet1_000316 FC(F)(F)c1ccc(=O)n(Cc2ccc(cc2)C(=O)NCc3cccnc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L19 compound treatment 0.366 -0.0105 -0.53 0.382 0.0149 0.9 0.2571 0.246 1907988 Bionet1_000317 COC(=O)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)c(=O)oc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L20 compound treatment 0.369 -0.00745 -0.38 0.377 0.00988 0.6 0.1521 0.215 1907989 Bionet1_000318 FC(F)(F)c1ccc(=O)n(Cc2ccc(cc2)C(=O)NCc3ccccn3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L21 compound treatment 0.378 0.00155 0.08 0.387 0.0199 1.2 0.9044 0.7521 1907990 Bionet1_000319 CN(C)/C=C/c1oc(=O)c(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L22 compound treatment 0.361 -0.0155 -0.79 0.372 0.00488 0.29 -0.3506 -0.4158 1907991 Bionet1_000320 Cc1cccc(NC(=O)c2ccc(Cn3cc(ccc3=O)C(F)(F)F)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L23 positive control 0.087 -0.289 -14.8 0.091 -0.276 -16.67 -22.2523 -0.9982 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 L24 positive control 0.097 -0.279 -14.29 0.1 -0.267 -16.13 -21.5066 -0.9982 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M01 mock treatment 0.396 0.0195 1.0 0.369 0.00188 0.11 0.7868 0.7822 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M02 mock treatment 0.356 -0.0205 -1.05 0.368 8.75E-4 0.05 -0.7021 -0.6705 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M03 compound treatment 0.393 0.0165 0.85 0.382 0.0149 0.9 1.2333 0.9996 1907992 Bionet1_000321 CCOC/1=NN(C(=O)\C1=C/NCc2cccs2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M04 compound treatment 0.458 0.0815 4.17 0.433 0.0659 3.98 5.7605 0.9997 1907993 Bionet1_000322 CO/N=C/c1ccc(Sc2cccc(c2)C(F)(F)F)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M05 compound treatment 0.354 -0.0225 -1.15 0.34 -0.0271 -1.64 -1.9696 -0.9849 1907994 Bionet1_000323 CCOC/1=NN(C(=O)\C1=C/NCc2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M06 compound treatment 0.424 0.0475 2.43 0.421 0.0539 3.25 4.0189 0.9897 1907995 Bionet1_000324 CO/N=C/c1ccc(SCc2cccc(c2)C(F)(F)F)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M07 compound treatment 0.383 0.00655 0.33 0.437 0.0699 4.22 3.2195 0.7608 1907996 Bionet1_000325 CCOC/1=NN(C(=O)\C1=C/Nc2ccc(O)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M08 compound treatment 0.383 0.00655 0.33 0.395 0.0279 1.68 1.4267 0.8315 1907997 Bionet1_000326 O/N=C/c1ccc(SCc2cccc(c2)C(F)(F)F)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M09 compound treatment 0.382 0.00555 0.28 0.393 0.0259 1.56 1.3051 0.8221 1907998 Bionet1_000327 CCSC(SCC)C(=O)NNC(=S)Nc1ccc(Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M10 compound treatment 0.389 0.0125 0.64 0.396 0.0289 1.74 1.6863 0.9078 1907999 Bionet1_000328 CC(C)Sc1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M11 compound treatment 0.378 0.00155 0.08 0.402 0.0349 2.11 1.5447 0.7332 1908000 Bionet1_000329 CCSC(SCC)C(=O)NNC(=S)Nc1cccc(c1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M12 compound treatment 0.456 0.0795 4.07 0.43 0.0629 3.8 5.5601 0.9994 1908001 Bionet1_000330 Clc1nc2sccn2c1/C=N/c3ccc(Oc4ccccc4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M13 compound treatment 0.402 0.0255 1.31 0.398 0.0309 1.86 2.2417 0.9849 1908002 Bionet1_000331 CN(C)c1nn(cc1c2ccc(Oc3ccccc3)cc2)C(=O)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M14 compound treatment 0.373 -0.00345 -0.18 0.379 0.0119 0.72 0.3821 0.5176 1908003 Bionet1_000332 CS/C(=N/C=[N+](C)C)/Nc1ccc(Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M15 compound treatment 0.381 0.00455 0.23 0.372 0.00488 0.29 0.3726 0.9932 1281020 Bionet1_000333 CN(C)c1nn(cc1c2ccc(Oc3ccccc3)cc2)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M16 compound treatment 0.372 -0.00445 -0.23 0.371 0.00388 0.23 0.0045 0.0137 1908004 Bionet1_000334 CS/C(=N/C=[N+](C)C)/Nc1ccccc1F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M17 compound treatment 0.369 -0.00745 -0.38 0.383 0.0159 0.96 0.4082 0.3958 1908005 Bionet1_000335 COC(=O)c1ccc(N/C=C\2/CCN(C2=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M18 compound treatment 0.385 0.00855 0.44 0.411 0.0439 2.65 2.182 0.8128 1651846 Bionet1_000336 CN(C)S(=O)(=O)c1ccc(NCc2n[nH]c(=O)c3ccccc23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M19 compound treatment 0.381 0.00455 0.23 0.395 0.0279 1.68 1.3543 0.7973 1908006 Bionet1_000337 CN(C)/C=C/c1snc(SCc2c(Cl)cccc2Cl)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M20 compound treatment 0.386 0.00955 0.49 0.379 0.0119 0.72 0.8521 0.9825 1908007 Bionet1_000338 Clc1ccc(cc1)N2CCN(Cc3n[nH]c(=O)c4ccccc34)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M21 compound treatment 0.373 -0.00345 -0.18 0.38 0.0129 0.78 0.4248 0.533 1908008 Bionet1_000339 CN(C)/C=C/c1snc(SCc2ccc(Cl)cc2Cl)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M22 compound treatment 0.381 0.00455 0.23 0.391 0.0239 1.44 1.1836 0.8107 1908009 Bionet1_000340 Clc1ccc(CONCc2n[nH]c(=O)c3ccccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M23 positive control 0.092 -0.284 -14.54 0.098 -0.269 -16.25 -21.7727 -0.9985 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 M24 positive control 0.1 -0.276 -14.14 0.099 -0.268 -16.19 -21.4408 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N01 mock treatment 0.373 -0.00345 -0.18 0.364 -0.00312 -0.19 -0.2582 -0.9994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N02 mock treatment 0.378 0.00155 0.08 0.366 -0.00112 -0.07 0.008 0.0763 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N03 compound treatment 0.365 -0.0115 -0.59 0.366 -0.00112 -0.07 -0.4621 -0.7839 1908010 Bionet1_000341 CCOC(=O)C(C)Sc1cc(nc(n1)c2ccccn2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N04 compound treatment 0.364 -0.0125 -0.64 0.377 0.00988 0.6 -0.0287 -0.0329 1908011 Bionet1_000342 FC(F)(F)c1ccc(=O)n(Cc2ccc(cc2)C(=O)NCc3cccs3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N05 compound treatment 0.374 -0.00245 -0.13 0.382 0.0149 0.9 0.5463 0.6026 1908012 Bionet1_000343 COC(=O)c1ccccc1Oc2cc(nc(n2)c3ccccn3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N06 compound treatment 0.424 0.0475 2.43 0.439 0.0719 4.34 4.7873 0.9625 1908013 Bionet1_000344 FC(F)(F)c1cc(c2ccc(nc2n1)N3CCOCC3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N07 compound treatment 0.363 -0.0135 -0.69 0.382 0.0149 0.9 0.1486 0.1314 1908014 Bionet1_000345 FC(F)(F)c1cc(Oc2ccccc2Cl)nc(n1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N08 compound treatment 0.373 -0.00345 -0.18 0.378 0.0109 0.66 0.3394 0.4993 1908015 Bionet1_000346 Cc1cc(C)n(n1)c2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N09 compound treatment 0.374 -0.00245 -0.13 0.382 0.0149 0.9 0.5463 0.6026 1908016 Bionet1_000347 FC(F)(F)c1cc(NCc2ccccc2C(F)(F)F)nc(n1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N10 compound treatment 0.389 0.0125 0.64 0.4 0.0329 1.98 1.857 0.8903 1908017 Bionet1_000348 FC(F)(F)c1cc(c2ccc(Nc3ccccc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N11 compound treatment 0.356 -0.0205 -1.05 0.372 0.00488 0.29 -0.5314 -0.4891 1908018 Bionet1_000349 FC(F)(F)c1cc(NCc2ccccc2Cl)nc(n1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N12 compound treatment 0.403 0.0265 1.36 0.398 0.0309 1.86 2.2778 0.9879 1908019 Bionet1_000350 COc1ccc(Nc2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N13 compound treatment 0.397 0.0205 1.05 0.394 0.0269 1.62 1.8902 0.9779 1908020 Bionet1_000351 Cn1nc(c(/C=N/OCc2c(Cl)cccc2Cl)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N14 compound treatment 0.394 0.0175 0.9 0.396 0.0289 1.74 1.8671 0.9523 1908021 Bionet1_000352 FC(F)(F)c1cc(c2ccc(Nc3ccc(Cl)cc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N15 compound treatment 0.366 -0.0105 -0.53 0.374 0.00688 0.42 -0.0844 -0.1248 1908022 Bionet1_000353 Cn1nc(c(/C=N/OCc2ccc(Cl)c(Cl)c2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N16 compound treatment 0.371 -0.00545 -0.28 0.373 0.00588 0.35 0.0537 0.119 1908023 Bionet1_000354 FC(F)(F)c1cc(c2ccc(Oc3ccc(Cl)cc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N17 compound treatment 0.378 0.00155 0.08 0.371 0.00388 0.23 0.2214 0.8965 1908024 Bionet1_000355 Cn1nc(c(/C=N/OCc2ccc(cc2)[N+](=O)[O-])c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N18 compound treatment 0.376 -4.52E-4 -0.02 0.369 0.00188 0.11 0.0637 0.5515 1908025 Bionet1_000356 FC(F)(F)c1cc(c2ccc(Nc3ccc(C#N)cc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N19 compound treatment 0.373 -0.00345 -0.18 0.375 0.00788 0.48 0.2114 0.4168 1908026 Bionet1_000357 Cn1nc(c(/C=N/OC(=O)c2ccc(Cl)cc2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N20 compound treatment 0.384 0.00755 0.39 0.372 0.00488 0.29 0.481 0.991 1908027 Bionet1_000358 CC(=O)c1ccccc1Nc2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N21 compound treatment 0.383 0.00655 0.33 0.366 -0.00112 -0.07 0.1887 0.5524 1908028 Bionet1_000359 Cn1nc(c(/C=N/OC(=O)c2cccc(c2)C(F)(F)F)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N22 compound treatment 0.371 -0.00545 -0.28 0.362 -0.00512 -0.31 -0.4159 -0.9986 1908029 Bionet1_000360 FC(F)(F)c1cc(c2ccc(Sc3ccccc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N23 positive control 0.095 -0.281 -14.39 0.093 -0.274 -16.55 -21.8777 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 N24 positive control 0.11 -0.266 -13.62 0.098 -0.269 -16.25 -21.1219 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O01 mock treatment 0.388 0.0115 0.59 0.373 0.00588 0.35 0.6683 0.9703 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O02 mock treatment 0.386 0.00955 0.49 0.372 0.00488 0.29 0.5533 0.9706 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O03 compound treatment 0.381 0.00455 0.23 0.378 0.0109 0.66 0.6287 0.9026 1908030 Bionet1_000361 CN(C)/C=C/c1snc(SCc2c(F)cccc2Cl)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O04 compound treatment 0.38 0.00355 0.18 0.386 0.0189 1.14 0.934 0.8095 1908031 Bionet1_000362 COC(=O)c1sccc1c2ccc(/C=N/OC(=O)c3ccccc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O05 compound treatment 0.468 0.0915 4.68 0.467 0.0999 6.03 7.5734 0.9922 1908032 Bionet1_000363 Cc1nc(CSc2nsc(/C=C/Nc3ccccc3)c2C#N)cs1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O06 compound treatment 0.392 0.0155 0.8 0.388 0.0209 1.26 1.4533 0.9753 1908033 Bionet1_000364 CCOC(=O)C(=Cc1ccc(o1)c2ccsc2C(=O)OC)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O07 compound treatment 0.385 0.00855 0.44 0.382 0.0149 0.9 0.944 0.9453 1908034 Bionet1_000365 Cc1cc(C)c(C(=O)N)c(NC(=O)Nc2cccc(c2)C(F)(F)F)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O08 compound treatment 0.417 0.0405 2.07 0.38 0.0129 0.78 2.0157 0.9103 1709704 Bionet1_000366 COC(=O)c1sccc1c2ccc(o2)C(=O)Nc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O09 compound treatment 0.388 0.0115 0.59 0.38 0.0129 0.78 0.9671 0.9908 1908035 Bionet1_000367 Cc1cc(C)c(C(=O)N)c(NC(=O)Nc2ccc(OC(F)(F)F)cc2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O10 compound treatment 0.373 -0.00345 -0.18 0.379 0.0119 0.72 0.3821 0.5176 1908036 Bionet1_000368 COC(=O)c1sccc1c2ccc(COC(=O)NC3CCCCC3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O11 compound treatment 0.397 0.0205 1.05 0.406 0.0389 2.35 2.4024 0.9343 1742999 Bionet1_000369 Clc1ccc(cc1)n2nc(C(=O)NCc3ccccc3)c4ccccc4c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O12 compound treatment 0.407 0.0305 1.56 0.406 0.0389 2.35 2.764 0.9804 1908037 Bionet1_000370 COC(=O)c1sccc1c2ccc(COC(=O)c3ccc(Cl)cc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O13 compound treatment 0.359 -0.0175 -0.89 0.378 0.0109 0.66 -0.1668 -0.1505 1162954 Bionet1_000371 Clc1ccc(cc1)n2nc(C(=O)N3CCCC3)c4ccccc4c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O14 compound treatment 0.381 0.00455 0.23 0.377 0.00988 0.6 0.586 0.9157 1908038 Bionet1_000372 COC(=O)c1sccc1c2ccc(COC(=O)Nc3ccccc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O15 compound treatment 0.367 -0.00945 -0.48 0.377 0.00988 0.6 0.0798 0.104 1908039 Bionet1_000373 Cn1nc(Cl)c(Cl)c1Oc2ccc(cc2)S(=O)(=O)Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O16 compound treatment 0.421 0.0445 2.28 0.413 0.0459 2.77 3.569 0.9953 1908040 Bionet1_000374 COC(=O)c1sccc1c2ccc(COC(=O)c3ccc(OC)cc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O17 compound treatment 0.403 0.0265 1.36 0.407 0.0399 2.41 2.662 0.9633 1427131 Bionet1_000375 Fc1ccc(cc1)n2nc(C(=O)Nc3ccccc3)c4ccccc4c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O18 compound treatment 0.381 0.00455 0.23 0.369 0.00188 0.11 0.2445 0.9452 1570750 Bionet1_000376 COC(=O)c1sc(nc1N)N2CCN(CC2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O19 compound treatment 0.366 -0.0105 -0.53 0.374 0.00688 0.42 -0.0844 -0.1248 1293220 Bionet1_000377 Fc1ccc(cc1)n2nc(C(=O)Oc3ccccc3)c4ccccc4c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O20 compound treatment 0.404 0.0275 1.41 0.385 0.0179 1.08 1.7591 0.9913 1201188 Bionet1_000378 O=C(c1cc(c(s1)N2CCOCC2)c3ccccn3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O21 compound treatment 0.387 0.0105 0.54 0.39 0.0229 1.38 1.3579 0.9159 1356705 Bionet1_000379 Clc1ccc(NC(=O)c2nn(c3ccccc3)c(=O)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O22 compound treatment 0.389 0.0125 0.64 0.383 0.0159 0.96 1.1314 0.981 1171077 Bionet1_000380 CN(C)c1sc(cc1c2ccc(Oc3ccccc3)cc2)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O23 positive control 0.097 -0.279 -14.29 0.092 -0.275 -16.61 -21.8481 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 O24 positive control 0.105 -0.271 -13.88 0.097 -0.27 -16.31 -21.3454 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P01 mock treatment 0.379 0.00255 0.13 0.375 0.00788 0.48 0.4283 0.8689 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P02 mock treatment 0.377 5.48E-4 0.03 0.363 -0.00412 -0.25 -0.1563 -0.6235 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P03 compound treatment 0.365 -0.0115 -0.59 0.373 0.00588 0.35 -0.1633 -0.2385 1125455 Bionet1_000381 Cc1oc(=O)c(NC(=O)c2cccc(Cl)c2)cc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P04 compound treatment 0.368 -0.00845 -0.43 0.362 -0.00512 -0.31 -0.5243 -0.9866 1908041 Bionet1_000382 FC(F)(F)c1cc(c2ccc(Oc3ccccc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P05 compound treatment 0.379 0.00255 0.13 0.373 0.00588 0.35 0.3429 0.9076 1420981 Bionet1_000383 CCOC(=O)c1cc(NC(=O)c2cccc(Cl)c2)c(=O)oc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P06 compound treatment 0.41 0.0335 1.72 0.387 0.0199 1.2 2.0614 0.9847 1908042 Bionet1_000384 COCCCNc1ccc2c(cc(nc2n1)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P07 compound treatment 0.379 0.00255 0.13 0.374 0.00688 0.42 0.3856 0.8864 1230065 Bionet1_000385 CCOC(=O)c1cc(NC(=O)c2ccc(C)cc2)c(=O)oc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P08 compound treatment 0.4 0.0235 1.2 0.392 0.0249 1.5 1.9133 0.994 1908043 Bionet1_000386 FC(F)(F)c1cc(c2ccc(SCc3ccccc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P09 compound treatment 0.384 0.00755 0.39 0.35 -0.0171 -1.03 -0.4581 -0.4151 1183648 Bionet1_000387 CN1CCN(CC1)C(=O)c2ccc(=O)n(Cc3ccc(Cl)c(Cl)c3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P10 compound treatment 0.374 -0.00245 -0.13 0.356 -0.0111 -0.67 -0.5635 -0.8248 1908044 Bionet1_000388 COc1ccc(Oc2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P11 compound treatment 0.373 -0.00345 -0.18 0.367 -1.25E-4 -0.01 -0.1301 -0.7367 1644688 Bionet1_000389 Clc1ccc(Cn2cc(ccc2=O)C(=O)Nc3ccccc3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P12 compound treatment 0.373 -0.00345 -0.18 0.365 -0.00212 -0.13 -0.2155 -0.9877 1908045 Bionet1_000390 Fc1ccc(Oc2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P13 compound treatment 0.378 0.00155 0.08 0.378 0.0109 0.66 0.5202 0.7867 1460766 Bionet1_000391 Clc1ccc(Cn2cc(ccc2=O)C(=O)NCc3ccccc3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P14 compound treatment 0.374 -0.00245 -0.13 0.37 0.00288 0.17 0.0341 0.1592 1908046 Bionet1_000392 Oc1ccc(Oc2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P15 compound treatment 0.377 5.48E-4 0.03 0.366 -0.00112 -0.07 -0.0282 -0.3837 1291088 Bionet1_000393 Fc1ccc(NC(=O)c2ccc(=O)n(Cc3ccc(Cl)c(Cl)c3)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P16 compound treatment 0.423 0.0465 2.38 0.424 0.0569 3.43 4.1108 0.984 1908047 Bionet1_000394 FC(F)(F)c1cc(c2ccc(nc2n1)N3CCNCC3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P17 compound treatment 0.401 0.0245 1.26 0.38 0.0129 0.78 1.4372 0.9734 1124809 Bionet1_000395 Clc1ccc(Cn2cc(ccc2=O)C(=O)Nc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P18 compound treatment 0.361 -0.0155 -0.79 0.371 0.00388 0.23 -0.3933 -0.4773 1908048 Bionet1_000396 NC(=O)C1CCN(CC1)c2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P19 compound treatment 0.377 5.48E-4 0.03 0.372 0.00488 0.29 0.2279 0.771 1147341 Bionet1_000397 Fc1ccc(NC(=O)c2ccc(=O)n(Cc3ccc(Cl)cc3)c2)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P20 compound treatment 0.38 0.00355 0.18 0.368 8.75E-4 0.05 0.1656 0.8766 1908049 Bionet1_000398 FC(F)(F)c1cnc(Oc2ccc(cc2)n3cc4ccsc4c3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P21 compound treatment 0.381 0.00455 0.23 0.36 -0.00712 -0.43 -0.1397 -0.2857 1728690 Bionet1_000399 CN(C(=O)c1ccc(=O)n(Cc2ccc(Cl)cc2)c1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P22 compound treatment 0.365 -0.0115 -0.59 0.365 -0.00212 -0.13 -0.5048 -0.842 1908050 Bionet1_000400 O=C(Nc1ccccc1)Nn2c(nnc2c3ccccn3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P23 positive control 0.092 -0.284 -14.54 0.091 -0.276 -16.67 -22.0716 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1234 P24 positive control 0.098 -0.278 -14.24 0.098 -0.269 -16.25 -21.5558 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A01 mock treatment 0.322 -0.0345 -1.77 0.324 -0.0321 -1.94 -2.62 -0.9989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A02 mock treatment 0.326 -0.0305 -1.56 0.328 -0.0281 -1.7 -2.3046 -0.9991 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A03 compound treatment 0.32 -0.0365 -1.87 0.33 -0.0261 -1.58 -2.4362 -0.9965 1910474 Bionet1_003921 Cn1nc(c2cc(sc12)C(=O)Nc3cccc(c3)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A04 compound treatment 0.321 -0.0355 -1.82 0.336 -0.0201 -1.22 -2.1439 -0.9809 1910475 Bionet1_003922 COc1ccc(/N=C/2\C(=O)N(Cc3ccccc3Cl)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A05 compound treatment 0.327 -0.0295 -1.51 0.327 -0.0291 -1.76 -2.3112 -0.9971 1910476 Bionet1_003923 Cn1nc(c2cc(sc12)C(=O)Nc3ccc(Cl)cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A06 compound treatment 0.329 -0.0275 -1.41 0.32 -0.0361 -2.18 -2.5377 -0.9776 1237657 Bionet1_003924 COCc1cc(nc(n1)S(=O)Cc2ccc(Cl)cc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A07 compound treatment 0.338 -0.0185 -0.95 0.333 -0.0231 -1.4 -1.6573 -0.9822 1910477 Bionet1_003925 Cc1cc(C)cc(/N=C\2/C(=O)N(Cc3ccccc3Cl)c4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A08 compound treatment 0.333 -0.0235 -1.2 0.326 -0.0301 -1.82 -2.1369 -0.9799 1910478 Bionet1_003926 CC(C)(C)C1COc2ccccc2N1C(=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A09 compound treatment 0.334 -0.0225 -1.15 0.321 -0.0351 -2.12 -2.3142 -0.9589 1910479 Bionet1_003927 Fc1ccc(/N=C\2/C(=O)N(Cc3ccccc3Cl)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A10 compound treatment 0.335 -0.0215 -1.1 0.333 -0.0231 -1.4 -1.7658 -0.9931 1279535 Bionet1_003928 OCc1cnc(S(=O)Cc2ccc(Cl)cc2)n1Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A11 compound treatment 0.333 -0.0235 -1.2 0.33 -0.0261 -1.58 -1.9662 -0.9911 1910480 Bionet1_003929 Cn1nc(c2cc(CSc3c(Cl)cccc3Cl)sc12)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A12 compound treatment 0.342 -0.0145 -0.74 0.328 -0.0281 -1.7 -1.7261 -0.9313 1910481 Bionet1_003930 FC(F)(F)c1cccc(CSCC(=O)c2cc(no2)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A13 compound treatment 0.334 -0.0225 -1.15 0.326 -0.0301 -1.82 -2.1008 -0.9757 1910482 Bionet1_003931 Cn1nc(c2cc(COc3ccc(Cl)cc3Cl)sc12)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A14 compound treatment 0.364 0.00747 0.38 0.354 -0.00213 -0.13 0.1792 0.4446 1910483 Bionet1_003932 Nc1nc(SCc2ccc(Cl)cc2)c(C#N)c(n1)c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A15 compound treatment 0.333 -0.0235 -1.2 0.331 -0.0251 -1.52 -1.9235 -0.9934 1910484 Bionet1_003933 Clc1ccc(CN2C(=O)/C(=N/c3ccc(Cl)cc3)/c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A16 compound treatment 0.34 -0.0165 -0.85 0.336 -0.0201 -1.22 -1.4569 -0.9843 1910485 Bionet1_003934 COc1ccc(CSc2nc(N)nc(c3cccs3)c2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A17 compound treatment 0.336 -0.0205 -1.05 0.326 -0.0301 -1.82 -2.0284 -0.9659 1910486 Bionet1_003935 COc1ccc(/N=C\2/C(=O)N(Cc3ccc(Cl)cc3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A18 compound treatment 0.333 -0.0235 -1.2 0.328 -0.0281 -1.7 -2.0515 -0.9858 1910487 Bionet1_003936 FC(F)(F)c1cccc(Cn2ccc(c(C#N)c2=O)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A19 compound treatment 0.338 -0.0185 -0.95 0.321 -0.0351 -2.12 -2.1696 -0.9341 1910488 Bionet1_003937 Fc1ccc(/N=C\2/C(=O)N(Cc3c(Cl)cccc3Cl)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A20 compound treatment 0.336 -0.0205 -1.05 0.328 -0.0281 -1.7 -1.9431 -0.9733 1613404 Bionet1_003938 Cc1ccc(cc1)S(=O)(=O)c2c(C)cc(C)nc2Oc3cccc(C)c3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A21 compound treatment 0.334 -0.0225 -1.15 0.321 -0.0351 -2.12 -2.3142 -0.9589 1910489 Bionet1_003939 Cc1cccc(C)c1NC(=O)O/N=C(/COc2ccccc2[N+](=O)[O-])\C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A22 compound treatment 0.331 -0.0255 -1.31 0.331 -0.0251 -1.52 -1.9958 -0.9972 1296756 Bionet1_003940 OC1(CN2CCOCC2)CCN(CC1)C(=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A23 positive control 0.084 -0.273 -13.94 0.088 -0.268 -16.19 -21.2992 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 A24 positive control 0.084 -0.273 -13.94 0.09 -0.266 -16.07 -21.2139 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B01 mock treatment 0.359 0.00247 0.13 0.352 -0.00413 -0.25 -0.087 -0.3114 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B02 mock treatment 0.362 0.00547 0.28 0.358 0.00187 0.11 0.2776 0.9205 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B03 compound treatment 0.364 0.00747 0.38 0.367 0.0109 0.66 0.7341 0.9668 1204177 Bionet1_003941 Cc1c(C)n(Cc2ccccc2)c(c1CNC(=O)c3cccs3)n4cccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B04 compound treatment 0.378 0.0215 1.1 0.374 0.0179 1.08 1.5391 1.0 1910490 Bionet1_003942 FCCCOc1ccc(cc1)/C(=C/Nc2cccc(c2)C(F)(F)F)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B05 compound treatment 0.359 0.00247 0.13 0.36 0.00387 0.23 0.2545 0.9582 1910491 Bionet1_003943 Fc1ccc(CSc2nnc(o2)c3sccc3n4cccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B06 compound treatment 0.372 0.0155 0.79 0.366 0.00987 0.6 0.9806 0.9903 1910492 Bionet1_003944 Fc1ccc(N/C=C/C(=O)c2cccc(OCc3c(F)cccc3Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B07 compound treatment 0.374 0.0175 0.89 0.362 0.00587 0.35 0.8822 0.9181 1910493 Bionet1_003945 Clc1cccc(CSc2nnc(o2)c3sccc3n4cccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B08 compound treatment 0.369 0.0125 0.64 0.366 0.00987 0.6 0.8722 0.9994 1910494 Bionet1_003946 Cc1ccc(cc1)S(=O)(=O)n2ccc(n2)c3ccc(OCCCF)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B09 compound treatment 0.368 0.0115 0.59 0.362 0.00587 0.35 0.6653 0.9709 1150751 Bionet1_003947 Fc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccc(nn3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B10 compound treatment 0.366 0.00947 0.48 0.362 0.00587 0.35 0.593 0.9882 1910495 Bionet1_003948 Cc1cccc(Oc2nc3cc(Cl)c(Cl)cc3nc2C(F)(F)F)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B11 compound treatment 0.366 0.00947 0.48 0.357 8.71E-4 0.05 0.3795 0.7793 1577897 Bionet1_003949 Cc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3cc(C)c4cccc(C)c4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B12 compound treatment 0.367 0.0105 0.54 0.358 0.00187 0.11 0.4584 0.8379 1910496 Bionet1_003950 FC(F)(F)c1cccc(/C=N/NC(=O)CN2CCS(=O)(=O)CC2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B13 compound treatment 0.36 0.00347 0.18 0.36 0.00387 0.23 0.2907 0.9907 1468747 Bionet1_003951 Cc1cc(C)c(C#N)c(n1)N2CCN(CC2)S(=O)(=O)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B14 compound treatment 0.359 0.00247 0.13 0.363 0.00687 0.41 0.3826 0.8823 1910497 Bionet1_003952 CC(C)(C)c1ccc(/C=N/NC(=O)CN2CCS(=O)(=O)CC2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B15 compound treatment 0.358 0.00147 0.08 0.358 0.00187 0.11 0.133 0.9803 1426726 Bionet1_003953 Cc1cc(C)c(C#N)c(n1)N2CCN(CC2)S(=O)(=O)Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B16 compound treatment 0.359 0.00247 0.13 0.356 -1.29E-4 -0.01 0.0838 0.6622 1910498 Bionet1_003954 CN(C)/C=C/c1c(nnn1c2cc(cc(c2)C(F)(F)F)C(F)(F)F)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B17 compound treatment 0.356 -5.31E-4 -0.03 0.363 0.00687 0.41 0.2741 0.6594 1640915 Bionet1_003955 Cc1ccc(NC(=O)N2CCC(CC2)c3nc4ccccc4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B18 compound treatment 0.373 0.0165 0.84 0.367 0.0109 0.66 1.0595 0.9924 1910499 Bionet1_003956 [O-][N+](=O)c1cc(N/C=C/C(=O)c2ccc(OCCCF)cc2)ccc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B19 compound treatment 0.359 0.00247 0.13 0.354 -0.00213 -0.13 -0.0016 -0.009 1711809 Bionet1_003957 Fc1ccc(NC(=O)N2CCC(CC2)c3nc4ccccc4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B20 compound treatment 0.364 0.00747 0.38 0.358 0.00187 0.11 0.3499 0.8786 1910500 Bionet1_003958 FCCCOc1ccc(cc1)C(=O)/C=C/Nc2ccc(Oc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B21 compound treatment 0.364 0.00747 0.38 0.359 0.00287 0.17 0.3926 0.9361 1166474 Bionet1_003959 Cc1cccc(NC(=O)N2CCC(CC2)c3nc4ccccc4s3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B22 compound treatment 0.353 -0.00353 -0.18 0.354 -0.00213 -0.13 -0.2186 -0.9861 1910501 Bionet1_003960 Clc1cccc(c1)C(=O)NNc2nc3ccccc3nc2Cc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B23 positive control 0.086 -0.271 -13.83 0.089 -0.267 -16.13 -21.1842 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 B24 positive control 0.084 -0.273 -13.94 0.09 -0.266 -16.07 -21.2139 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C01 mock treatment 0.358 0.00147 0.08 0.353 -0.00313 -0.19 -0.0805 -0.3958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C02 mock treatment 0.366 0.00947 0.48 0.36 0.00387 0.23 0.5076 0.9442 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C03 compound treatment 0.355 -0.00153 -0.08 0.362 0.00587 0.35 0.1952 0.5379 1201562 Bionet1_003961 Cc1ccc(cc1)S(=O)(=O)N2C(COc3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C04 compound treatment 0.362 0.00547 0.28 0.361 0.00487 0.29 0.4057 0.9997 1910502 Bionet1_003962 CCOC(=O)c1ccc(/N=C/c2ccccc2Oc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C05 compound treatment 0.358 0.00147 0.08 0.36 0.00387 0.23 0.2183 0.8895 1424451 Bionet1_003963 Cc1ccc2OCC(N(c2c1)S(=O)(=O)c3ccc(Cl)cc3)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C06 compound treatment 0.371 0.0145 0.74 0.364 0.00787 0.48 0.8591 0.9771 1910503 Bionet1_003964 COC(OC)c1ccnc(n1)c2ccc(OC(=O)c3cccs3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C07 compound treatment 0.36 0.00347 0.18 0.353 -0.00313 -0.19 -0.0082 -0.0315 1169169 Bionet1_003965 COc1ccc(cc1)S(=O)(=O)N2C(COc3ccc(C)cc23)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C08 compound treatment 0.373 0.0165 0.84 0.366 0.00987 0.6 1.0168 0.9857 1910504 Bionet1_003966 COC(OC)c1ccnc(n1)c2ccc(OC(=O)c3ccc(F)cc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C09 compound treatment 0.363 0.00647 0.33 0.357 8.71E-4 0.05 0.2711 0.8093 1910505 Bionet1_003967 Cc1ccc2OCC(N(C(=O)c3cccc(c3)C(F)(F)F)c2c1)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C10 compound treatment 0.365 0.00847 0.43 0.354 -0.00213 -0.13 0.2153 0.4767 1910506 Bionet1_003968 FCCCOc1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C11 compound treatment 0.355 -0.00153 -0.08 0.351 -0.00513 -0.31 -0.2743 -0.8589 1910507 Bionet1_003969 Clc1cccc(c1)C(=O)NCCOC(=O)Nc2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C12 compound treatment 0.365 0.00847 0.43 0.358 0.00187 0.11 0.3861 0.8627 1910508 Bionet1_003970 COC(OC)c1ccnc(n1)c2ccc(OC(=O)c3ccc(cc3)[N+](=O)[O-])cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C13 compound treatment 0.388 0.0315 1.61 0.37 0.0139 0.84 1.7299 0.9537 1910509 Bionet1_003971 Brc1cccc(c1)C(=O)NCCOC(=O)Nc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C14 compound treatment 0.388 0.0315 1.61 0.37 0.0139 0.84 1.7299 0.9537 1598935 Bionet1_003972 Clc1cccc(C(=O)c2c[nH]c(c2)C(=O)NCc3cccs3)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C15 compound treatment 0.357 4.69E-4 0.02 0.354 -0.00213 -0.13 -0.0739 -0.5655 1910510 Bionet1_003973 Cn1nc(c(/C=C/C(=O)c2ccc(Cl)c(Cl)c2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C16 compound treatment 0.357 4.69E-4 0.02 0.356 -1.29E-4 -0.01 0.0114 0.4539 1910511 Bionet1_003974 CN(C)CCCNC(=O)c1cc(c[nH]1)C(=O)c2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C17 compound treatment 0.357 4.69E-4 0.02 0.356 -1.29E-4 -0.01 0.0114 0.4539 1910512 Bionet1_003975 CCOC(=O)c1cnc(nc1Sc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C18 compound treatment 0.357 4.69E-4 0.02 0.362 0.00587 0.35 0.2676 0.7532 1217050 Bionet1_003976 Clc1cccc(Cl)c1C(=O)c2c[nH]c(c2)C(=O)NCc3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C19 compound treatment 0.348 -0.00853 -0.44 0.355 -0.00113 -0.07 -0.3567 -0.8078 1910513 Bionet1_003977 CCOC(=O)c1cnc(nc1Sc2ccc(C)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C20 compound treatment 0.375 0.0185 0.94 0.37 0.0139 0.84 1.2599 0.9982 1430862 Bionet1_003978 Clc1cccc(Cl)c1C(=O)c2c[nH]c(c2)C(=O)NC3CCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C21 compound treatment 0.358 0.00147 0.08 0.357 8.71E-4 0.05 0.0903 0.9848 1910514 Bionet1_003979 CCOC(=O)c1cnc(nc1Sc2cccc(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C22 compound treatment 0.372 0.0155 0.79 0.364 0.00787 0.48 0.8953 0.9703 1242005 Bionet1_003980 Fc1ccc(CNC(=O)c2cc(c[nH]2)C(=O)c3cccc(Cl)c3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C23 positive control 0.085 -0.272 -13.88 0.088 -0.268 -16.19 -21.2631 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 C24 positive control 0.084 -0.273 -13.94 0.093 -0.263 -15.88 -21.0858 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D01 mock treatment 0.342 -0.0145 -0.74 0.344 -0.0121 -0.73 -1.0431 -1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D02 mock treatment 0.346 -0.0105 -0.54 0.348 -0.00813 -0.49 -0.7278 -0.9989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D03 compound treatment 0.351 -0.00553 -0.28 0.351 -0.00513 -0.31 -0.4189 -0.999 1126842 Bionet1_003981 Clc1cccc(NC(=O)N2CCC(CC2)c3nc4ccccc4s3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D04 compound treatment 0.361 0.00447 0.23 0.357 8.71E-4 0.05 0.1988 0.8477 1910515 Bionet1_003982 FCCCOc1ccc(/C=C/C(=O)NCc2ccc3OCOc3c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D05 compound treatment 0.352 -0.00453 -0.23 0.346 -0.0101 -0.61 -0.5962 -0.9118 1315490 Bionet1_003983 Clc1ccc(NC(=O)N2CCC(CC2)c3nc4ccccc4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D06 compound treatment 0.359 0.00247 0.13 0.354 -0.00213 -0.13 -0.0016 -0.009 1910516 Bionet1_003984 [O-][N+](=O)c1cc(NS(=O)(=O)c2cc(Cl)ccc2Cl)ccc1F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D07 compound treatment 0.355 -0.00153 -0.08 0.357 8.71E-4 0.05 -0.0182 -0.1928 1351800 Bionet1_003985 Cc1cc(C)c(C#N)c(n1)N2CCCN(CC2)S(=O)(=O)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D08 compound treatment 0.366 0.00947 0.48 0.366 0.00987 0.6 0.7637 0.9947 1910517 Bionet1_003986 COc1ccc(CNC(=O)/C=C/c2ccc(OCCCF)cc2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D09 compound treatment 0.351 -0.00553 -0.28 0.349 -0.00713 -0.43 -0.5043 -0.9793 1910518 Bionet1_003987 Cc1cccc(CO/N=C/c2c(nc3ccc(Cl)cn23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D10 compound treatment 0.358 0.00147 0.08 0.344 -0.0121 -0.73 -0.4646 -0.6313 1910519 Bionet1_003988 Cc1ccc(N/C=C/C(=O)c2cccc(OCc3c(F)cccc3Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D11 compound treatment 0.364 0.00747 0.38 0.347 -0.00913 -0.55 -0.1196 -0.1785 1910520 Bionet1_003989 Fc1ccc(CO/N=C/c2c(nc3ccc(Cl)cn23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D12 compound treatment 0.362 0.00547 0.28 0.347 -0.00913 -0.55 -0.192 -0.3106 1389989 Bionet1_003990 Cc1cc(I)cn2cc(nc12)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D13 compound treatment 0.357 4.69E-4 0.02 0.346 -0.0101 -0.61 -0.4154 -0.6789 1910521 Bionet1_003991 Cc1ccn2c(/C=N/OCc3ccc(F)cc3)c(nc2c1)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D14 compound treatment 0.358 0.00147 0.08 0.343 -0.0131 -0.79 -0.5073 -0.6373 1141909 Bionet1_003992 CC(C)CC(N1Cc2ccccc2C1=O)C(=O)Nc3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D15 compound treatment 0.355 -0.00153 -0.08 0.343 -0.0131 -0.79 -0.6158 -0.7732 1910522 Bionet1_003993 Cc1ccn2c(/C=N/OCc3cccc(F)c3)c(nc2c1)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D16 compound treatment 0.364 0.00747 0.38 0.356 -1.29E-4 -0.01 0.2645 0.6925 1512809 Bionet1_003994 OCC(Cc1ccccc1)NC(=O)c2ccc(I)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D17 compound treatment 0.363 0.00647 0.33 0.35 -0.00613 -0.37 -0.0277 -0.0559 1910523 Bionet1_003995 Sc1nnc(c2cccs2)n1/N=C/c3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D18 compound treatment 0.353 -0.00353 -0.18 0.35 -0.00613 -0.37 -0.3893 -0.9456 1215520 Bionet1_003996 OCC(NC(=O)c1ccc(I)cc1)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D19 compound treatment 0.344 -0.0125 -0.64 0.344 -0.0121 -0.73 -0.9708 -0.9978 1910524 Bionet1_003997 Nn1c(SCc2c(Cl)cccc2Cl)nnc1c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D20 compound treatment 0.366 0.00947 0.48 0.369 0.0129 0.78 0.8918 0.9741 1910525 Bionet1_003998 FC(F)(F)c1cccc(c1)c2cn3cc(I)ccc3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D21 compound treatment 0.355 -0.00153 -0.08 0.342 -0.0141 -0.85 -0.6585 -0.7688 1910526 Bionet1_003999 COC(=O)c1sccc1n2cccc2C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D22 compound treatment 0.358 0.00147 0.08 0.359 0.00287 0.17 0.1757 0.93 1910527 Bionet1_004000 COc1ccc(N/C=C/C(=O)c2sc(nc2C)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D23 positive control 0.086 -0.271 -13.83 0.091 -0.265 -16.01 -21.0989 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 D24 positive control 0.088 -0.269 -13.73 0.093 -0.263 -15.88 -20.9412 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E01 mock treatment 0.352 -0.00453 -0.23 0.353 -0.00313 -0.19 -0.2974 -0.9949 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E02 mock treatment 0.36 0.00347 0.18 0.358 0.00187 0.11 0.2053 0.9763 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E03 compound treatment 0.359 0.00247 0.13 0.356 -1.29E-4 -0.01 0.0838 0.6622 1910528 Bionet1_004001 CCOC(=O)c1cnc(nc1Sc2cccc(C)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E04 compound treatment 0.366 0.00947 0.48 0.365 0.00887 0.54 0.721 0.9987 1910529 Bionet1_004002 COC(OC)c1ccnc(n1)c2ccc(OC(=O)c3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E05 compound treatment 0.359 0.00247 0.13 0.351 -0.00513 -0.31 -0.1297 -0.3878 1910530 Bionet1_004003 CCOC(=O)c1cnc(nc1Sc2ccc(OC)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E06 compound treatment 0.449 0.0925 4.73 0.462 0.106 6.39 7.8626 0.989 1910531 Bionet1_004004 CCOC(=O)C/C(=N/NC(=O)/C(=N/Nc1ccccc1[N+](=O)[O-])/C#N)/C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E07 compound treatment 0.365 0.00847 0.43 0.348 -0.00813 -0.49 -0.0408 -0.0624 1910532 Bionet1_004005 CCOC(=O)c1cnc(nc1Sc2cc(C)ccc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E08 compound treatment 0.445 0.0885 4.52 0.431 0.0749 4.52 6.3947 1.0 1910533 Bionet1_004006 CCCc1c(C)nn(C(=O)/C(=N/Nc2ccccc2[N+](=O)[O-])/C#N)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E09 compound treatment 0.366 0.00947 0.48 0.363 0.00687 0.41 0.6357 0.997 1180452 Bionet1_004007 CCOC(=O)c1cnc(nc1Oc2ccc(Cl)c(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E10 compound treatment 0.473 0.116 5.96 0.463 0.107 6.45 8.773 0.9992 1910534 Bionet1_004008 CC/C(=N\NC(=O)\C(=N\Nc1ccccc1[N+](=O)[O-])\C#N)/CC(=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E11 compound treatment 0.37 0.0135 0.69 0.359 0.00287 0.17 0.6095 0.8583 1247003 Bionet1_004009 CCOC(=O)c1cnc(nc1Oc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E12 compound treatment 0.364 0.00747 0.38 0.357 8.71E-4 0.05 0.3072 0.7969 1910535 Bionet1_004010 Fc1cc(ccc1I)c2nccc(n2)c3ccco3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E13 compound treatment 0.364 0.00747 0.38 0.359 0.00287 0.17 0.3926 0.9361 1910536 Bionet1_004011 CCOC(=O)c1cnc(nc1Oc2cccc(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E14 compound treatment 0.418 0.0615 3.14 0.402 0.0459 2.77 4.1806 0.998 1910537 Bionet1_004012 C/C(=N\NC(=O)\C(=N\Nc1ccccc1[N+](=O)[O-])\C#N)/CC(=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E15 compound treatment 0.373 0.0165 0.84 0.365 0.00887 0.54 0.9741 0.9761 1498796 Bionet1_004013 Clc1ccc(Sc2nc(ncc2C(=O)NCC=C)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E16 compound treatment 0.388 0.0315 1.61 0.364 0.00787 0.48 1.4738 0.8784 1910538 Bionet1_004014 [O-][N+](=O)c1ccc(Oc2ccc(c(F)c2)c3ccccc3)c(Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E17 compound treatment 0.369 0.0125 0.64 0.351 -0.00513 -0.31 0.2319 0.3272 1910539 Bionet1_004015 CO/N=C(/CCS(=O)(=O)c1ccc(C)cc1)\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E18 compound treatment 0.363 0.00647 0.33 0.346 -0.0101 -0.61 -0.1985 -0.2855 1910540 Bionet1_004016 Fc1ccc(N/C=C/C(=O)c2ccc(OCc3c(F)cccc3Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E19 compound treatment 0.365 0.00847 0.43 0.349 -0.00713 -0.43 0.0019 0.0031 1236485 Bionet1_004017 Cc1ccc(Sc2cc3ccccc3nc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E20 compound treatment 0.371 0.0145 0.74 0.378 0.0219 1.32 1.4567 0.9625 1910541 Bionet1_004018 Cc1ccc(N/C=C/C(=O)c2ccc(OCc3c(F)cccc3Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E21 compound treatment 0.366 0.00947 0.48 0.357 8.71E-4 0.05 0.3795 0.7793 1910542 Bionet1_004019 Clc1ccc(Sc2cc3ccccc3nc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E22 compound treatment 0.363 0.00647 0.33 0.37 0.0139 0.84 0.826 0.9174 1910543 Bionet1_004020 Clc1ccc(COc2ccc(/C=C/C(=O)N3CCOCC3)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E23 positive control 0.087 -0.27 -13.78 0.097 -0.259 -15.64 -20.8066 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 E24 positive control 0.093 -0.264 -13.47 0.095 -0.261 -15.76 -20.675 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F01 mock treatment 0.354 -0.00253 -0.13 0.351 -0.00513 -0.31 -0.3105 -0.9251 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F02 mock treatment 0.359 0.00247 0.13 0.359 0.00287 0.17 0.2118 0.9879 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F03 compound treatment 0.368 0.0115 0.59 0.368 0.0119 0.72 0.9214 0.995 1910544 Bionet1_004021 COc1cnc(nc1Sc2ccc(Br)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F04 compound treatment 0.367 0.0105 0.54 0.356 -1.29E-4 -0.01 0.373 0.6967 1910545 Bionet1_004022 Cc1nc(sc1C(=O)/C=C/Nc2ccc(C)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F05 compound treatment 0.372 0.0155 0.79 0.37 0.0139 0.84 1.1514 0.9996 1665399 Bionet1_004023 O=c1cc(N2CCN(CC2)S(=O)(=O)c3ccccc3)c(n[nH]1)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F06 compound treatment 0.363 0.00647 0.33 0.358 0.00187 0.11 0.3138 0.8977 1910546 Bionet1_004024 Cc1nc(sc1C(=O)C2C(c3ccccc3)C2(C#N)C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F07 compound treatment 0.371 0.0145 0.74 0.363 0.00687 0.41 0.8164 0.9626 1512031 Bionet1_004025 O=C(N1CCOCC1)c2cc3cccnc3n2S(=O)(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F08 compound treatment 0.382 0.0255 1.3 0.37 0.0139 0.84 1.513 0.9772 1910547 Bionet1_004026 Clc1ccc(CNC(=O)/C=C/c2cnc3ccccc3c2)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F09 compound treatment 0.382 0.0255 1.3 0.359 0.00287 0.17 1.0434 0.7942 1910548 Bionet1_004027 Clc1ccc(Sc2cc(Cl)c(nn2)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F10 compound treatment 0.393 0.0365 1.86 0.387 0.0309 1.86 2.6364 1.0 1910549 Bionet1_004028 Brc1ccc(cc1)C(=O)CSc2nccn2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F11 compound treatment 0.37 0.0135 0.69 0.351 -0.00513 -0.31 0.268 0.355 1910550 Bionet1_004029 Clc1cc(Sc2ccc(Br)cc2)nnc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F12 compound treatment 0.365 0.00847 0.43 0.361 0.00487 0.29 0.5141 0.9822 1910551 Bionet1_004030 Clc1cc(OCc2ccccc2)ccc1C(=O)NNC(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F13 compound treatment 0.384 0.0275 1.4 0.366 0.00987 0.6 1.4145 0.9271 1910552 Bionet1_004031 Clc1ccc(Oc2cc(Cl)c(nn2)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F14 compound treatment 0.4 0.0435 2.22 0.371 0.0149 0.9 2.2065 0.9205 1910553 Bionet1_004032 CCNC(=S)NNC(=O)c1ccc(OCc2ccccc2)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F15 compound treatment 0.39 0.0335 1.71 0.37 0.0139 0.84 1.8022 0.9459 1910554 Bionet1_004033 COc1cnc(nc1Sc2cccc(Cl)c2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F16 compound treatment 0.381 0.0245 1.25 0.358 0.00187 0.11 0.9646 0.7678 1910555 Bionet1_004034 Clc1cc(OCc2ccccc2)ccc1C(=O)NNC(=S)NCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F17 compound treatment 0.375 0.0185 0.94 0.357 8.71E-4 0.05 0.7049 0.7453 1910556 Bionet1_004035 COc1cnc(nc1Sc2ccc(Cl)cc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F18 compound treatment 0.383 0.0265 1.35 0.358 0.00187 0.11 1.0369 0.7635 1642801 Bionet1_004036 Clc1ccccc1CNC(=O)c2ccc(OCc3ccccc3)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F19 compound treatment 0.375 0.0185 0.94 0.367 0.0109 0.66 1.1318 0.9842 1910557 Bionet1_004037 CCN(CC)C(=O)C(=O)c1cccn1c2c(sc3ccccc23)C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F20 compound treatment 0.376 0.0195 1.0 0.364 0.00787 0.48 1.0399 0.9427 1910558 Bionet1_004038 O=C1N(CCCSc2nccn2c3ccccc3)C(=O)c4ccccc14 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F21 compound treatment 0.374 0.0175 0.89 0.366 0.00987 0.6 1.053 0.9806 1910559 Bionet1_004039 CCCNC(=O)C(=O)c1cccn1c2c(sc3ccccc23)C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F22 compound treatment 0.368 0.0115 0.59 0.354 -0.00213 -0.13 0.3238 0.5393 1359490 Bionet1_004040 CCOC(=O)c1nc2ccc(I)cn2c1Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F23 positive control 0.091 -0.266 -13.58 0.092 -0.264 -15.95 -20.8754 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 F24 positive control 0.1 -0.257 -13.12 0.094 -0.262 -15.82 -20.4646 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G01 mock treatment 0.339 -0.0175 -0.9 0.349 -0.00713 -0.43 -0.9382 -0.9435 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G02 mock treatment 0.352 -0.00453 -0.23 0.352 -0.00413 -0.25 -0.3401 -0.9993 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G03 compound treatment 0.362 0.00547 0.28 0.35 -0.00613 -0.37 -0.0639 -0.1378 1462038 Bionet1_004041 Clc1ccc(cc1)C23N(CCN3C(=O)c4ccccc42)C(=O)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G04 compound treatment 0.394 0.0375 1.92 0.395 0.0389 2.35 3.014 0.9949 1910560 Bionet1_004042 CC(Oc1ccc(c(F)c1)c2ccccc2)C(=O)/C=C/Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G05 compound treatment 0.399 0.0425 2.17 0.387 0.0309 1.86 2.8533 0.9971 1327272 Bionet1_004043 COc1ccc(Sc2cc3ccccc3nc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G06 compound treatment 0.392 0.0355 1.81 0.382 0.0259 1.56 2.3868 0.9972 1910561 Bionet1_004044 CCC(C)NC(=O)/C=C/c1ccc(OCc2ccc(Cl)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G07 compound treatment 0.41 0.0535 2.73 0.421 0.0649 3.92 4.7024 0.9846 1340843 Bionet1_004045 Brc1ccc(Sc2cc3ccccc3nc2c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G08 compound treatment 0.357 4.69E-4 0.02 0.345 -0.0111 -0.67 -0.4581 -0.6814 1910562 Bionet1_004046 [O-][N+](=O)c1ccc(Oc2ccc(Br)cc2)c(Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G09 compound treatment 0.356 -5.31E-4 -0.03 0.342 -0.0141 -0.85 -0.6223 -0.7293 1910563 Bionet1_004047 ClCC(=O)N1CCN2C(=O)c3ccccc3C12c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G10 compound treatment 0.438 0.0815 4.17 0.419 0.0629 3.8 5.6294 0.9989 1910564 Bionet1_004048 [O-][N+](=O)c1ccc(cc1)N2CCN(Cc3ccc(OCCCF)cc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G11 compound treatment 0.367 0.0105 0.54 0.344 -0.0121 -0.73 -0.1392 -0.1535 1910565 Bionet1_004049 Brc1ccc(cc1)c2ccc(NC(=O)c3ccccc3)c(=O)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G12 compound treatment 0.374 0.0175 0.89 0.372 0.0159 0.96 1.3091 0.9994 1910566 Bionet1_004050 FCCCOc1ccc(/C=C/C(=O)N2CCN(Cc3ccccc3)CC2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G13 compound treatment 0.365 0.00847 0.43 0.352 -0.00413 -0.25 0.1299 0.2601 1910567 Bionet1_004051 Brc1ccc(cc1)c2ccc(NC(=O)c3cccs3)c(=O)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G14 compound treatment 0.374 0.0175 0.89 0.371 0.0149 0.9 1.2664 1.0 1910568 Bionet1_004052 Cc1ccc(N2CCN(CC2)C(=O)/C=C/c3ccc(OCCCF)cc3)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G15 compound treatment 0.362 0.00547 0.28 0.35 -0.00613 -0.37 -0.0639 -0.1378 1694638 Bionet1_004053 Fc1ccc(cc1)n2ncc(NCc3ccccc3)c(Br)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G16 compound treatment 0.39 0.0335 1.71 0.38 0.0239 1.44 2.2291 0.9963 1910569 Bionet1_004054 FCCCOc1ccc(/C=C/C(=O)NCc2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G17 compound treatment 0.37 0.0135 0.69 0.358 0.00187 0.11 0.5668 0.8122 1331363 Bionet1_004055 Fc1ccc(cc1)n2ncc(Cl)c(Oc3ccc(Cl)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G18 compound treatment 0.375 0.0185 0.94 0.359 0.00287 0.17 0.7903 0.8231 1910570 Bionet1_004056 COc1ccccc1/N=C/c2cc(Br)cc(Br)c2O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G19 compound treatment 0.358 0.00147 0.08 0.354 -0.00213 -0.13 -0.0378 -0.2538 1305425 Bionet1_004057 Cn1nc(c(CN2CCN(CC2)c3ccccc3)c1Cl)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G20 compound treatment 0.361 0.00447 0.23 0.366 0.00987 0.6 0.5829 0.9134 1910571 Bionet1_004058 FC(F)(Cl)c1nnc2ccc(Sc3nc4ccccc4s3)nn12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G21 compound treatment 0.356 -5.31E-4 -0.03 0.355 -0.00113 -0.07 -0.0674 -0.9187 1327484 Bionet1_004059 COc1ccc(Oc2c(Br)cnn(c3ccc(C)cc3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G22 compound treatment 0.361 0.00447 0.23 0.349 -0.00713 -0.43 -0.1427 -0.2929 1910572 Bionet1_004060 COC(=O)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G23 positive control 0.09 -0.267 -13.63 0.094 -0.262 -15.82 -20.8262 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 G24 positive control 0.102 -0.255 -13.01 0.097 -0.259 -15.64 -20.2642 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H01 mock treatment 0.352 -0.00453 -0.23 0.358 0.00187 0.11 -0.084 -0.3258 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H02 mock treatment 0.365 0.00847 0.43 0.357 8.71E-4 0.05 0.3434 0.7872 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H03 compound treatment 0.363 0.00647 0.33 0.367 0.0109 0.66 0.6979 0.9497 1910573 Bionet1_004061 COC(=O)c1sc2ccccc2c1n3cccc3C(=O)C(=O)NC(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H04 compound treatment 0.525 0.168 8.61 0.507 0.151 9.11 12.5314 0.9996 1910574 Bionet1_004062 COc1ccc(N/C=C/C(=O)c2sc(nc2C)c3cccnc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H05 compound treatment 0.343 -0.0135 -0.69 0.336 -0.0201 -1.22 -1.3485 -0.9644 1910575 Bionet1_004063 FC(F)(F)c1cccc(Oc2ncc(cn2)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H06 compound treatment 0.381 0.0245 1.25 0.383 0.0269 1.62 2.0317 0.9918 1910576 Bionet1_004064 Cc1nc(sc1C(=O)/C=C/Nc2ccc(Cl)cc2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H07 compound treatment 0.409 0.0525 2.68 0.378 0.0219 1.32 2.8307 0.9467 1910577 Bionet1_004065 Clc1ccc(cc1)c2cnc(Oc3cc(Cl)ccc3Cl)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H08 compound treatment 0.352 -0.00453 -0.23 0.348 -0.00813 -0.49 -0.5108 -0.9413 1302957 Bionet1_004066 CC1(C)CC(=O)C2(C(c3ccc(Cl)cc3Cl)C2(C#N)C#N)C(=O)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H09 compound treatment 0.398 0.0415 2.12 0.393 0.0369 2.23 3.0733 0.9997 1910578 Bionet1_004067 COc1cnc(nc1Sc2ccccc2)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H10 compound treatment 0.413 0.0565 2.89 0.395 0.0389 2.35 3.701 0.9947 1910579 Bionet1_004068 CN(C)/C=C/C(=C/C(=O)C(F)(F)F)/Nc1ccccc1c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H11 compound treatment 0.388 0.0315 1.61 0.376 0.0199 1.2 1.986 0.9895 1910580 Bionet1_004069 Cc1cccc(CO/N=C/c2c(nc3cc(C)ccn23)c4ccc(Cl)cc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H12 compound treatment 0.449 0.0925 4.73 0.415 0.0589 3.55 5.8563 0.9901 1910581 Bionet1_004070 COC(=O)c1cc(Cl)ccc1N/C(=C/C(=O)C(F)(F)F)/C=C/N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H13 compound treatment 0.385 0.0285 1.46 0.361 0.00487 0.29 1.2372 0.8331 1910582 Bionet1_004071 Cc1cccc(CO/N=C/c2c(nc3c(C)cccn23)c4ccc(Cl)cc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H14 compound treatment 0.364 0.00747 0.38 0.364 0.00787 0.48 0.606 0.9941 1910583 Bionet1_004072 FC(F)(F)c1cccc(Oc2ccc(cc2)C3=C(CCC(=O)N3)C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H15 compound treatment 0.374 0.0175 0.89 0.37 0.0139 0.84 1.2237 0.9995 1910584 Bionet1_004073 Cc1cccn2c(/C=N/OCc3cccc(F)c3)c(nc12)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H16 compound treatment 0.437 0.0805 4.11 0.426 0.0699 4.22 5.892 0.9999 1910585 Bionet1_004074 Oc1nc2cc(Cl)c(Cl)cc2nc1c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H17 compound treatment 0.38 0.0235 1.2 0.363 0.00687 0.41 1.1418 0.8993 1910586 Bionet1_004075 Cc1cccn2c(/C=N/OCc3ccc(F)cc3)c(nc12)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H18 compound treatment 0.376 0.0195 1.0 0.36 0.00387 0.23 0.8692 0.85 1910587 Bionet1_004076 CN(C)/C=C/C(=O)C(Cc1ccc(Cl)cc1)Cc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H19 compound treatment 0.348 -0.00853 -0.44 0.362 0.00587 0.35 -0.0578 -0.1029 1910588 Bionet1_004077 COC(=O)c1nn(c(Cl)c1/C=N/OCc2cccc(F)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H20 compound treatment 0.359 0.00247 0.13 0.356 -1.29E-4 -0.01 0.0838 0.6622 1910589 Bionet1_004078 OC(CN(Cc1ccc(Cl)cc1)C(=O)Nc2ccccc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H21 compound treatment 0.365 0.00847 0.43 0.363 0.00687 0.41 0.5995 0.9998 1910590 Bionet1_004079 COC(=O)c1nn(c(Cl)c1/C=N/OCc2ccc(C)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H22 compound treatment 0.356 -5.31E-4 -0.03 0.358 0.00187 0.11 0.0607 0.5222 1910591 Bionet1_004080 COc1ccc(cc1)C(=O)c2nnn(c2C)c3ccc(OC(F)(F)F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H23 positive control 0.094 -0.263 -13.42 0.092 -0.264 -15.95 -20.7669 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 H24 positive control 0.102 -0.255 -13.01 0.098 -0.258 -15.58 -20.2216 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I01 mock treatment 0.351 -0.00553 -0.28 0.35 -0.00613 -0.37 -0.4616 -0.9912 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I02 mock treatment 0.362 0.00547 0.28 0.355 -0.00113 -0.07 0.1495 0.5195 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I03 compound treatment 0.357 4.69E-4 0.02 0.351 -0.00513 -0.31 -0.202 -0.6504 1193122 Bionet1_004081 Cc1ccc(Sc2c(NCC=C)cnn(c3ccc(C)cc3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I04 compound treatment 0.358 0.00147 0.08 0.358 0.00187 0.11 0.133 0.9803 1666051 Bionet1_004082 COC(=O)c1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I05 compound treatment 0.383 0.0265 1.35 0.371 0.0149 0.9 1.5918 0.9801 1910592 Bionet1_004083 COc1ccc(NC(=O)c2cc3c(nn(C)c3s2)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I06 compound treatment 0.349 -0.00753 -0.39 0.354 -0.00213 -0.13 -0.3632 -0.8946 1910593 Bionet1_004084 FC(F)(F)c1ccc(Sc2ccc3nnc(n3n2)C(F)(F)Cl)nc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I07 compound treatment 0.391 0.0345 1.76 0.368 0.0119 0.72 1.753 0.9214 1207473 Bionet1_004085 Cc1ccc(Sc2c(cnn(c3ccc(C)cc3)c2=O)N4CCOCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I08 compound treatment 0.387 0.0305 1.56 0.372 0.0159 0.96 1.7791 0.9727 1910594 Bionet1_004086 Oc1c(Br)cc(Br)cc1/C=N/c2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I09 compound treatment 0.382 0.0255 1.3 0.382 0.0259 1.56 2.0252 0.9959 1571009 Bionet1_004087 Cc1cc(oc(=O)c1NC(=O)c2ccccc2)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I10 compound treatment 0.413 0.0565 2.89 0.409 0.0529 3.19 4.2986 0.9987 1910595 Bionet1_004088 Oc1c(Br)cc(Br)cc1/C=N/c2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I11 compound treatment 0.385 0.0285 1.46 0.37 0.0139 0.84 1.6214 0.9655 1665602 Bionet1_004089 Cc1ccc(cc1)C(=O)Nc2c(C)cc(oc2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I12 compound treatment 0.351 -0.00553 -0.28 0.345 -0.0111 -0.67 -0.6751 -0.9261 1129145 Bionet1_004090 Oc1c(Br)cc(Br)cc1CNc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I13 compound treatment 0.379 0.0225 1.15 0.387 0.0309 1.86 2.1302 0.973 1910596 Bionet1_004091 Cn1nc(c2ccccc2)c3cc(sc13)c4nnc(SCC=C)n4C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I14 compound treatment 0.362 0.00547 0.28 0.353 -0.00313 -0.19 0.0642 0.1901 1466882 Bionet1_004092 Oc1c(Br)cc(Br)cc1CNc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I15 compound treatment 0.372 0.0155 0.79 0.355 -0.00113 -0.07 0.5111 0.6438 1910597 Bionet1_004093 FC(F)(F)c1cccc(Cn2ccc(c(C#N)c2=O)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I16 compound treatment 0.388 0.0315 1.61 0.381 0.0249 1.5 2.1994 0.9994 1532611 Bionet1_004094 O=C(COc1ccc(cc1)c2nccc(n2)c3cccs3)NC4CCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I17 compound treatment 0.372 0.0155 0.79 0.379 0.0229 1.38 1.5356 0.965 1700098 Bionet1_004095 O=C(NCc1ccc(cc1)C(=O)NC2CCCCC2)OCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I18 compound treatment 0.393 0.0365 1.86 0.374 0.0179 1.08 2.0814 0.9662 1910598 Bionet1_004096 FCCCOc1ccc(cc1)/C(=C/Nc2ccc(OC(F)(F)F)cc2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I19 compound treatment 0.375 0.0185 0.94 0.354 -0.00213 -0.13 0.5769 0.6053 1536021 Bionet1_004097 Clc1ccc(NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I20 compound treatment 0.366 0.00947 0.48 0.358 0.00187 0.11 0.4222 0.8493 1910599 Bionet1_004098 Cc1ccc(/C=N/Nc2nc3ccccc3nc2Cc4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I21 compound treatment 0.352 -0.00453 -0.23 0.356 -1.29E-4 -0.01 -0.1693 -0.7305 1675083 Bionet1_004099 OC(c1cccs1)c2cc3cccnc3n2S(=O)(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I22 compound treatment 0.395 0.0385 1.97 0.382 0.0259 1.56 2.4952 0.9935 1910600 Bionet1_004100 COc1ccc(O)c(/C=N/Nc2nc3ccccc3nc2Cc4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I23 positive control 0.088 -0.269 -13.73 0.094 -0.262 -15.82 -20.8985 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 I24 positive control 0.097 -0.26 -13.27 0.098 -0.258 -15.58 -20.4023 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J01 mock treatment 0.346 -0.0105 -0.54 0.353 -0.00313 -0.19 -0.5143 -0.9013 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J02 mock treatment 0.364 0.00747 0.38 0.362 0.00587 0.35 0.5207 0.9993 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J03 compound treatment 0.38 0.0235 1.2 0.38 0.0239 1.44 1.8675 0.9959 1910601 Bionet1_004101 C/C(=N\OC(=O)Nc1ccccc1)/c2sc(nc2C)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J04 compound treatment 0.361 0.00447 0.23 0.358 0.00187 0.11 0.2414 0.9472 1910602 Bionet1_004102 CC(C(=O)c1cn(nn1)c2ccc(OC(F)(F)F)cc2)n3cncn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J05 compound treatment 0.358 0.00147 0.08 0.368 0.0119 0.72 0.5598 0.777 1910603 Bionet1_004103 CC(C)NC(=O)O/N=C(\C)/c1sc(nc1C)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J06 compound treatment 0.411 0.0545 2.79 0.389 0.0329 1.98 3.3725 0.9862 1262418 Bionet1_004104 CCCc1ccc(c(F)c1)c2ccc(cc2)c3[nH]ncc3c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J07 compound treatment 0.346 -0.0105 -0.54 0.338 -0.0181 -1.09 -1.1546 -0.9466 1389812 Bionet1_004105 Clc1cccc(Cn2nc(c3ccccc3)c(cc2=O)N4CCCCC4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J08 compound treatment 0.358 0.00147 0.08 0.371 0.0149 0.9 0.6879 0.7636 1584495 Bionet1_004106 C=CCNC(=O)CN1C(=O)C2C(C3c4ccccc4C2c5ccccc35)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J09 compound treatment 0.381 0.0245 1.25 0.372 0.0159 0.96 1.5622 0.9913 1910604 Bionet1_004107 O=C(NNC(=O)c1ccccc1)C(=O)c2c([nH]c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J10 compound treatment 0.37 0.0135 0.69 0.37 0.0139 0.84 1.0791 0.9953 1658850 Bionet1_004108 Cc1nc2ccccn2c1C(=O)CSc3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J11 compound treatment 0.365 0.00847 0.43 0.364 0.00787 0.48 0.6422 0.9989 1447737 Bionet1_004109 CCOC(=O)CON1C(=O)C2C(C3c4ccccc4C2c5ccccc35)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J12 compound treatment 0.379 0.0225 1.15 0.361 0.00487 0.29 1.0203 0.8604 1910605 Bionet1_004110 Cc1nc2ccccn2c1C(=O)CSc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J13 compound treatment 0.367 0.0105 0.54 0.35 -0.00613 -0.37 0.1169 0.1796 1910606 Bionet1_004111 Cc1ccc(CSc2nc(Cl)c3sc4ccccc4c3n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J14 compound treatment 0.356 -5.31E-4 -0.03 0.347 -0.00913 -0.55 -0.4089 -0.7411 1910607 Bionet1_004112 Cc1ccc(/C=N/NC(=O)C2CCN(CC2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J15 compound treatment 0.367 0.0105 0.54 0.354 -0.00213 -0.13 0.2876 0.5225 1910608 Bionet1_004113 CSc1nc(Sc2ccc(Cl)cc2)c3sc4ccccc4c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J16 compound treatment 0.375 0.0185 0.94 0.366 0.00987 0.6 1.0891 0.9754 1910609 Bionet1_004114 CC/C=N/NC(=O)C1CCN(CC1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J17 compound treatment 0.396 0.0395 2.02 0.387 0.0309 1.86 2.7448 0.9992 1910610 Bionet1_004115 C=CCSc1nc(Sc2ccccc2)c3sc4ccccc4c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J18 compound treatment 0.372 0.0155 0.79 0.355 -0.00113 -0.07 0.5111 0.6438 1910611 Bionet1_004116 Clc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)N/N=C/c3ccco3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J19 compound treatment 0.36 0.00347 0.18 0.355 -0.00113 -0.07 0.0772 0.4064 1910612 Bionet1_004117 C=CCSc1nc(Oc2ccccc2)c3sc4ccccc4c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J20 compound treatment 0.363 0.00647 0.33 0.372 0.0159 0.96 0.9114 0.8991 1301549 Bionet1_004118 COCc1cc(nc(SCc2ccc(Cl)cc2)n1)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J21 compound treatment 0.36 0.00347 0.18 0.358 0.00187 0.11 0.2053 0.9763 1910613 Bionet1_004119 Cc1ccccc1Oc2nc(SCC=C)nc3c4ccccc4sc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J22 compound treatment 0.383 0.0265 1.35 0.371 0.0149 0.9 1.5918 0.9801 1910614 Bionet1_004120 FC(F)(F)c1ccc(C(=O)N2CCCC2)c(=O)n1Cc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J23 positive control 0.089 -0.268 -13.68 0.092 -0.264 -15.95 -20.9477 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 J24 positive control 0.097 -0.26 -13.27 0.098 -0.258 -15.58 -20.4023 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K01 mock treatment 0.353 -0.00353 -0.18 0.355 -0.00113 -0.07 -0.1759 -0.9113 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K02 mock treatment 0.362 0.00547 0.28 0.355 -0.00113 -0.07 0.1495 0.5195 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K03 compound treatment 0.361 0.00447 0.23 0.364 0.00787 0.48 0.4976 0.9437 1910615 Bionet1_004121 Cc1ccc(cc1)C(=O)NNC(=O)c2cc3cc(ccc3s2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K04 compound treatment 0.373 0.0165 0.84 0.362 0.00587 0.35 0.8461 0.926 1910616 Bionet1_004122 FCCCOc1ccc(/C=N/NC(=O)c2ccc(cc2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K05 compound treatment 0.357 4.69E-4 0.02 0.354 -0.00213 -0.13 -0.0739 -0.5655 1910617 Bionet1_004123 COC(=O)c1sccc1n2cccc2C(=O)C(=O)N3CC(C)OC(C)C3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K06 compound treatment 0.357 4.69E-4 0.02 0.346 -0.0101 -0.61 -0.4154 -0.6789 1509151 Bionet1_004124 CN1C(=O)C(CC(=O)c2ccc(Br)cc2)C(=O)N(C)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K07 compound treatment 0.39 0.0335 1.71 0.367 0.0109 0.66 1.6741 0.9134 1910618 Bionet1_004125 COC(=O)c1sccc1n2cccc2C(=O)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K08 compound treatment 0.364 0.00747 0.38 0.363 0.00687 0.41 0.5633 0.9991 1910619 Bionet1_004126 Cc1ccc(Oc2nc3cc(Cl)c(Cl)cc3nc2C(F)(F)F)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K09 compound treatment 0.352 -0.00453 -0.23 0.339 -0.0171 -1.03 -0.895 -0.8446 1910620 Bionet1_004127 Brc1ccc(NC(=O)c2snnc2c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K10 compound treatment 0.393 0.0365 1.86 0.379 0.0229 1.38 2.2949 0.9891 1910621 Bionet1_004128 Oc1c(Br)cc(Br)cc1/C=N/Cc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K11 compound treatment 0.368 0.0115 0.59 0.357 8.71E-4 0.05 0.4518 0.7674 1910622 Bionet1_004129 Clc1cc(Cl)cc(NC(=O)c2snnc2c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K12 compound treatment 0.372 0.0155 0.79 0.349 -0.00713 -0.43 0.255 0.2832 1910623 Bionet1_004130 COc1cc(NC(=O)Cc2ncc(cc2Cl)C(F)(F)F)cc(OC)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K13 compound treatment 0.378 0.0215 1.1 0.356 -1.29E-4 -0.01 0.7707 0.7021 1910624 Bionet1_004131 COc1ccc(/C=C/C(=O)c2sc(nc2C)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K14 compound treatment 0.359 0.00247 0.13 0.342 -0.0141 -0.85 -0.5139 -0.596 1910625 Bionet1_004132 CCCCCC1CCC(CC1)c2ccc(/N=C/c3ccc4OCOc4c3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K15 compound treatment 0.408 0.0515 2.63 0.389 0.0329 1.98 3.2641 0.9903 1910626 Bionet1_004133 CSc1cc(c(s1)C(=O)Nc2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K16 compound treatment 0.372 0.0155 0.79 0.364 0.00787 0.48 0.8953 0.9703 1167061 Bionet1_004134 CC(C)N(C(C)C)C(=O)CC1ON(C)C(=O)N1c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K17 compound treatment 0.4 0.0435 2.22 0.362 0.00587 0.35 1.8223 0.8096 1910627 Bionet1_004135 CSc1cc(c(s1)C(=O)Nc2ccc(F)cc2F)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K18 compound treatment 0.352 -0.00453 -0.23 0.348 -0.00813 -0.49 -0.5108 -0.9413 1910628 Bionet1_004136 FC(F)(F)c1cc(nc(c1C#N)c2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K19 compound treatment 0.357 4.69E-4 0.02 0.355 -0.00113 -0.07 -0.0312 -0.4325 1910629 Bionet1_004137 COc1ccc(NC(=O)c2sc(SC)cc2c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K20 compound treatment 0.358 0.00147 0.08 0.355 -0.00113 -0.07 0.0049 0.0484 1910630 Bionet1_004138 Cc1cccc(n1)n2cnc(c2)C(=O)NNC(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K21 compound treatment 0.362 0.00547 0.28 0.353 -0.00313 -0.19 0.0642 0.1901 1910631 Bionet1_004139 C/C(=N\OC(=O)c1ccc(Cl)cc1)/c2sc(nc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K22 compound treatment 0.365 0.00847 0.43 0.359 0.00287 0.17 0.4287 0.9192 1558123 Bionet1_004140 Clc1ccc(SCC2CNc3nc4ccccc4c(=O)n23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K23 positive control 0.094 -0.263 -13.42 0.091 -0.265 -16.01 -20.8096 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 K24 positive control 0.099 -0.258 -13.17 0.099 -0.257 -15.52 -20.2873 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L01 mock treatment 0.358 0.00147 0.08 0.356 -1.29E-4 -0.01 0.0476 0.6304 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L02 mock treatment 0.365 0.00847 0.43 0.36 0.00387 0.23 0.4714 0.9581 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L03 compound treatment 0.361 0.00447 0.23 0.354 -0.00213 -0.13 0.0707 0.2696 1910632 Bionet1_004141 FC(F)(F)c1cc(=O)n(nc1C(=O)c2ccccc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L04 compound treatment 0.373 0.0165 0.84 0.36 0.00387 0.23 0.7607 0.8704 1910633 Bionet1_004142 COc1cccc(OC)c1C(=O)NNC(=O)c2ccccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L05 compound treatment 0.356 -5.31E-4 -0.03 0.352 -0.00413 -0.25 -0.1955 -0.7796 1910634 Bionet1_004143 FC(F)(F)c1cc(=O)n(nc1C(=O)c2cccc(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L06 compound treatment 0.356 -5.31E-4 -0.03 0.354 -0.00213 -0.13 -0.1101 -0.838 1910635 Bionet1_004144 FC(F)(F)c1cccc(c1)C(=O)NNC(=O)c2ccccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L07 compound treatment 0.365 0.00847 0.43 0.358 0.00187 0.11 0.3861 0.8627 1910636 Bionet1_004145 Fc1ccc(cc1)C(=O)NCc2nnc(SCC=C)n2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L08 compound treatment 0.367 0.0105 0.54 0.362 0.00587 0.35 0.6291 0.98 1323434 Bionet1_004146 Cc1c(C)n(Cc2ccccc2)c(c1CNC(=O)c3ccc(C)cc3)n4cccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L09 compound treatment 0.37 0.0135 0.69 0.354 -0.00213 -0.13 0.3961 0.5654 1281362 Bionet1_004147 COc1ccc(Oc2c(cnn(c3ccc(C)cc3)c2=O)N(C)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L10 compound treatment 0.372 0.0155 0.79 0.368 0.0119 0.72 1.066 0.9988 1220573 Bionet1_004148 CCNC(=O)NCc1c(C)c(C)n(Cc2ccccc2)c1n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L11 compound treatment 0.385 0.0285 1.46 0.366 0.00987 0.6 1.4507 0.9223 1614859 Bionet1_004149 COC(=O)c1ccccc1Sc2nccc(c2C#N)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L12 compound treatment 0.37 0.0135 0.69 0.36 0.00387 0.23 0.6522 0.8968 1910637 Bionet1_004150 COc1ccc(CSc2nnc(o2)c3sccc3n4cccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L13 compound treatment 0.386 0.0295 1.51 0.365 0.00887 0.54 1.4441 0.9031 1910638 Bionet1_004151 FC(F)(F)c1cccc(c1)c2ccnc(Sc3cccc(Cl)c3)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L14 compound treatment 0.392 0.0355 1.81 0.361 0.00487 0.29 1.4903 0.8112 1910639 Bionet1_004152 Clc1ccc(CSc2nnc(o2)c3sccc3n4cccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L15 compound treatment 0.353 -0.00353 -0.18 0.343 -0.0131 -0.79 -0.6881 -0.8465 1910640 Bionet1_004153 CN(C)CCCNC(=O)/C=C/c1ccc(OCc2c(F)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L16 compound treatment 0.381 0.0245 1.25 0.362 0.00587 0.35 1.1353 0.8731 1649372 Bionet1_004154 Cc1c(C)n(Cc2ccccc2)c(c1CNC(=O)c3cccc(C)c3)n4cccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L17 compound treatment 0.37 0.0135 0.69 0.357 8.71E-4 0.05 0.5242 0.7589 1910641 Bionet1_004155 COC(OC)c1ccnc(n1)c2ccc(I)c(F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L18 compound treatment 0.368 0.0115 0.59 0.37 0.0139 0.84 1.0068 0.9848 1321471 Bionet1_004156 CCn1c(SCC=C)nnc1c2nn(ccc2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L19 compound treatment 0.36 0.00347 0.18 0.357 8.71E-4 0.05 0.1626 0.8789 1910642 Bionet1_004157 COC(=O)/C(=C/c1ccnc(n1)c2ccc(OC(=O)c3cccs3)cc2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L20 compound treatment 0.371 0.0145 0.74 0.37 0.0139 0.84 1.1152 0.9981 1447893 Bionet1_004158 CCn1c(SC=C=C)nnc1c2nn(ccc2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L21 compound treatment 0.37 0.0135 0.69 0.359 0.00287 0.17 0.6095 0.8583 1910643 Bionet1_004159 Cc1ccc(CNC(=O)/C=C/c2ccc(OCc3cccc(Cl)c3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L22 compound treatment 0.366 0.00947 0.48 0.358 0.00187 0.11 0.4222 0.8493 1702159 Bionet1_004160 Cc1cccc2c(C)cc(nc12)N3CCN(CC3)S(=O)(=O)c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L23 positive control 0.096 -0.261 -13.32 0.091 -0.265 -16.01 -20.7373 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 L24 positive control 0.097 -0.26 -13.27 0.103 -0.253 -15.28 -20.1889 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M01 mock treatment 0.362 0.00547 0.28 0.359 0.00287 0.17 0.3203 0.9735 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M02 mock treatment 0.369 0.0125 0.64 0.363 0.00687 0.41 0.7441 0.9783 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M03 compound treatment 0.378 0.0215 1.1 0.366 0.00987 0.6 1.1976 0.9588 1910644 Bionet1_004161 C/C(=N\OC(=O)Nc1ccccc1)/c2sc(nc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M04 compound treatment 0.366 0.00947 0.48 0.356 -1.29E-4 -0.01 0.3368 0.6956 1175101 Bionet1_004162 Brc1ccc(SCC2CNc3nc4ccccc4c(=O)n23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M05 compound treatment 0.361 0.00447 0.23 0.37 0.0139 0.84 0.7537 0.8683 1910645 Bionet1_004163 COC(=O)c1sc2ccccc2c1n3cccc3C(=O)C(=O)N4CCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M06 compound treatment 0.364 0.00747 0.38 0.352 -0.00413 -0.25 0.0938 0.2056 1910646 Bionet1_004164 Cc1ccc(cc1)S(=O)(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M07 compound treatment 0.371 0.0145 0.74 0.366 0.00987 0.6 0.9445 0.9942 1280576 Bionet1_004165 Fc1ccc(cc1)C(=O)N2CCN(CC2)c3cc(=O)[nH]nc3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M08 compound treatment 0.362 0.00547 0.28 0.354 -0.00213 -0.13 0.1068 0.3472 1910647 Bionet1_004166 Clc1ccc(cc1)S(=O)(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M09 compound treatment 0.375 0.0185 0.94 0.367 0.0109 0.66 1.1318 0.9842 1740589 Bionet1_004167 O=C(N1CCN(CC1)c2cc(=O)[nH]nc2c3ccccc3)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M10 compound treatment 0.364 0.00747 0.38 0.354 -0.00213 -0.13 0.1792 0.4446 1910648 Bionet1_004168 Fc1ccc(cc1)S(=O)(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M11 compound treatment 0.376 0.0195 1.0 0.368 0.0119 0.72 1.2106 0.987 1168227 Bionet1_004169 Cc1ccc(cc1)C(=O)N2CCN(CC2)c3cc(=O)[nH]nc3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M12 compound treatment 0.364 0.00747 0.38 0.361 0.00487 0.29 0.478 0.9917 1910649 Bionet1_004170 COc1ccc(cc1)S(=O)(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M13 compound treatment 0.364 0.00747 0.38 0.359 0.00287 0.17 0.3926 0.9361 1292933 Bionet1_004171 Fc1ccccc1N2CCN(CC2)C(=O)c3snnc3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M14 compound treatment 0.369 0.0125 0.64 0.358 0.00187 0.11 0.5307 0.8196 1910650 Bionet1_004172 Fc1ccccc1S(=O)(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M15 compound treatment 0.365 0.00847 0.43 0.357 8.71E-4 0.05 0.3434 0.7872 1910651 Bionet1_004173 CC(C)NC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M16 compound treatment 0.359 0.00247 0.13 0.352 -0.00413 -0.25 -0.087 -0.3114 1910652 Bionet1_004174 Clc1ccc(NC(=O)NNC(=O)c2sccc2n3cccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M17 compound treatment 0.373 0.0165 0.84 0.361 0.00487 0.29 0.8034 0.9007 1910653 Bionet1_004175 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NC2CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M18 compound treatment 0.37 0.0135 0.69 0.362 0.00587 0.35 0.7376 0.9523 1910654 Bionet1_004176 Clc1cccc(NC(=O)NNC(=O)c2sccc2n3cccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M19 compound treatment 0.359 0.00247 0.13 0.36 0.00387 0.23 0.2545 0.9582 1910655 Bionet1_004177 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M20 compound treatment 0.366 0.00947 0.48 0.364 0.00787 0.48 0.6783 1.0 1910656 Bionet1_004178 Cc1cccc(C)c1NC(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M21 compound treatment 0.369 0.0125 0.64 0.359 0.00287 0.17 0.5734 0.8678 1910657 Bionet1_004179 CCCNC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M22 compound treatment 0.366 0.00947 0.48 0.355 -0.00113 -0.07 0.2942 0.6016 1910658 Bionet1_004180 FC(F)(F)c1cccc(NC(=O)NNC(=O)c2sccc2n3cccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M23 positive control 0.097 -0.26 -13.27 0.093 -0.263 -15.88 -20.6158 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 M24 positive control 0.094 -0.263 -13.42 0.097 -0.259 -15.64 -20.5535 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N01 mock treatment 0.359 0.00247 0.13 0.356 -1.29E-4 -0.01 0.0838 0.6622 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N02 mock treatment 0.363 0.00647 0.33 0.363 0.00687 0.41 0.5272 0.9937 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N03 compound treatment 0.384 0.0275 1.4 0.386 0.0299 1.8 2.2683 0.9924 1910659 Bionet1_004181 Clc1cccc(COc2ccc(/C=C/C(=O)NCc3cccs3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N04 compound treatment 0.396 0.0395 2.02 0.379 0.0229 1.38 2.4033 0.9829 1230704 Bionet1_004182 Cc1cccc2c(C)cc(nc12)N3CCN(CC3)S(=O)(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N05 compound treatment 0.382 0.0255 1.3 0.376 0.0199 1.2 1.7691 0.9992 1910660 Bionet1_004183 COc1ccc(NC(=O)/C=C/c2ccc(OCc3cccc(Cl)c3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N06 compound treatment 0.378 0.0215 1.1 0.366 0.00987 0.6 1.1976 0.9588 1357420 Bionet1_004184 Cc1cccc2c(C)cc(nc12)N3CCN(CC3)S(=O)(=O)Cc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N07 compound treatment 0.421 0.0645 3.3 0.398 0.0419 2.53 4.1183 0.9914 1910661 Bionet1_004185 Clc1cccc(COc2ccc(/C=C/C(=O)NC3CCCC3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N08 compound treatment 0.4 0.0435 2.22 0.358 0.00187 0.11 1.6515 0.7421 1628224 Bionet1_004186 Cc1ccc(cc1)S(=O)(=O)N2CCCN(CC2)c3nc(C)cc(C)c3C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N09 compound treatment 0.387 0.0305 1.56 0.372 0.0159 0.96 1.7791 0.9727 1910662 Bionet1_004187 Clc1cccc(COc2ccc(/C=C/C(=O)N3CCOCC3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N10 compound treatment 0.372 0.0155 0.79 0.355 -0.00113 -0.07 0.5111 0.6438 1910663 Bionet1_004188 COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)CCl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N11 compound treatment 0.368 0.0115 0.59 0.35 -0.00613 -0.37 0.153 0.2207 1910664 Bionet1_004189 OC/1/C(=C/c2ccccc2)/CN(Cc3ccccc3)C\C1=C/c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N12 compound treatment 0.377 0.0205 1.05 0.375 0.0189 1.14 1.5456 0.9991 1716810 Bionet1_004190 Clc1ccc(CNC(=O)c2ccc(cc2)N3CCCC3=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N13 compound treatment 0.386 0.0295 1.51 0.378 0.0219 1.32 1.9991 0.9978 1910665 Bionet1_004191 Clc1ccc(CNC(=O)/C=C/c2ccc(OCc3ccccc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N14 compound treatment 0.389 0.0325 1.66 0.384 0.0279 1.68 2.3637 1.0 1607137 Bionet1_004192 Clc1ccc(cc1)N2CCN(CC2)C(=O)c3ccc(cc3)N4CCCC4=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N15 compound treatment 0.39 0.0335 1.71 0.373 0.0169 1.02 1.9303 0.9693 1910666 Bionet1_004193 COc1ccc(NC(=O)/C=C/c2ccc(OCc3ccccc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N16 compound treatment 0.382 0.0255 1.3 0.362 0.00587 0.35 1.1715 0.868 1910667 Bionet1_004194 FC(F)(F)c1nc2cc(Cl)c(Cl)cc2nc1Oc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N17 compound treatment 0.411 0.0545 2.79 0.392 0.0359 2.17 3.5006 0.9923 1910668 Bionet1_004195 CC(Oc1ccc(c(F)c1)c2ccccc2)C(=O)/C=C/Nc3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N18 compound treatment 0.374 0.0175 0.89 0.365 0.00887 0.54 1.0103 0.9701 1910669 Bionet1_004196 Clc1ccc(CC(=O)c2c[nH]c(c2)C(=O)NCCCN3CCOCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N19 compound treatment 0.39 0.0335 1.71 0.368 0.0119 0.72 1.7168 0.9254 1910670 Bionet1_004197 [O-][N+](=O)c1ccc(Sc2c(Cl)cccc2Cl)c(Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N20 compound treatment 0.37 0.0135 0.69 0.366 0.00987 0.6 0.9083 0.9974 1910671 Bionet1_004198 Cc1cccc(C)c1Oc2nc3cc(Cl)c(Cl)cc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N21 compound treatment 0.376 0.0195 1.0 0.368 0.0119 0.72 1.2106 0.987 1910672 Bionet1_004199 CCC(C)NC(=O)/C=C/c1ccc(OCc2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N22 compound treatment 0.369 0.0125 0.64 0.357 8.71E-4 0.05 0.488 0.7628 1548784 Bionet1_004200 Oc1c(Br)cc(Br)cc1CNCc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N23 positive control 0.097 -0.26 -13.27 0.094 -0.262 -15.82 -20.5731 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 N24 positive control 0.095 -0.262 -13.37 0.098 -0.258 -15.58 -20.4747 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O01 mock treatment 0.373 0.0165 0.84 0.372 0.0159 0.96 1.2729 0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O02 mock treatment 0.364 0.00747 0.38 0.368 0.0119 0.72 0.7768 0.9566 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O03 compound treatment 0.366 0.00947 0.48 0.36 0.00387 0.23 0.5076 0.9442 1910673 Bionet1_004201 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NNC(=O)C2CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O04 compound treatment 0.372 0.0155 0.79 0.366 0.00987 0.6 0.9806 0.9903 1910674 Bionet1_004202 Cc1ccc(cc1)S(=O)(=O)NNC(=O)c2ccccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O05 compound treatment 0.366 0.00947 0.48 0.378 0.0219 1.32 1.276 0.9073 1124798 Bionet1_004203 OC1(CSc2ccccc2)CCN(CC1)C(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O06 compound treatment 0.372 0.0155 0.79 0.365 0.00887 0.54 0.938 0.982 1910675 Bionet1_004204 Clc1ccc(C(=O)NNC(=O)c2ccccc2n3cccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O07 compound treatment 0.387 0.0305 1.56 0.37 0.0139 0.84 1.6937 0.9576 1183970 Bionet1_004205 OC1(CSc2ccc(Cl)cc2)CCN(CC1)C(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O08 compound treatment 0.376 0.0195 1.0 0.379 0.0229 1.38 1.6802 0.9871 1910676 Bionet1_004206 Clc1ccc(cc1Cl)C(=O)NNC(=O)c2ccccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O09 compound treatment 0.396 0.0395 2.02 0.389 0.0329 1.98 2.8302 1.0 1591346 Bionet1_004207 Cc1cc(C)cc(Oc2nc(cc(C)c2S(=O)(=O)C)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O10 compound treatment 0.372 0.0155 0.79 0.37 0.0139 0.84 1.1514 0.9996 1910677 Bionet1_004208 COc1ccc(cc1)S(=O)(=O)NNC(=O)c2ccccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O11 compound treatment 0.395 0.0385 1.97 0.392 0.0359 2.17 2.9221 0.9988 1376188 Bionet1_004209 Cc1cccc(Oc2nc(cc(C)c2S(=O)(=O)C)c3ccccc3)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O12 compound treatment 0.374 0.0175 0.89 0.366 0.00987 0.6 1.053 0.9806 1910678 Bionet1_004210 Fc1ccccc1S(=O)(=O)NNC(=O)c2ccccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O13 compound treatment 0.374 0.0175 0.89 0.368 0.0119 0.72 1.1383 0.994 1542456 Bionet1_004211 CCN(CC)CC1(O)CCN(CC1)C(=O)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O14 compound treatment 0.377 0.0205 1.05 0.364 0.00787 0.48 1.0761 0.9362 1910679 Bionet1_004212 COC(=O)c1ccccc1S(=O)(=O)NNC(=O)c2ccccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O15 compound treatment 0.373 0.0165 0.84 0.374 0.0179 1.08 1.3583 0.9925 1910680 Bionet1_004213 Cn1cc(C(=O)N2CCN(CC2)c3ccccc3F)c(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O16 compound treatment 0.386 0.0295 1.51 0.372 0.0159 0.96 1.743 0.9761 1910681 Bionet1_004214 Clc1ccc(/C=N\NC(=O)c2sccc2n3cccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O17 compound treatment 0.387 0.0305 1.56 0.375 0.0189 1.14 1.9072 0.9882 1910682 Bionet1_004215 Cn1cc(NC(=O)OCc2ccc(Cl)cc2Cl)c(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O18 compound treatment 0.367 0.0105 0.54 0.359 0.00287 0.17 0.5011 0.8905 1910683 Bionet1_004216 Clc1ccc(/C=N\NC(=O)c2ccccc2n3cccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O19 compound treatment 0.381 0.0245 1.25 0.369 0.0129 0.78 1.4341 0.9737 1910684 Bionet1_004217 CC(OC(=O)Nc1ccc(Cl)c(Cl)c1)c2sc3ncnn3c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O20 compound treatment 0.364 0.00747 0.38 0.363 0.00687 0.41 0.5633 0.9991 1910685 Bionet1_004218 Brc1cccc(/C=N\NC(=O)c2ccccc2n3cccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O21 compound treatment 0.369 0.0125 0.64 0.369 0.0129 0.78 1.0002 0.9952 1234447 Bionet1_004219 CCS(=O)(=O)c1ccc(C(=O)Nc2ccccc2)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O22 compound treatment 0.364 0.00747 0.38 0.366 0.00987 0.6 0.6914 0.9769 1910686 Bionet1_004220 C/C(=N\NC(=O)c1sccc1n2cccc2)/c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O23 positive control 0.092 -0.265 -13.53 0.093 -0.263 -15.88 -20.7966 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 O24 positive control 0.093 -0.264 -13.47 0.098 -0.258 -15.58 -20.547 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P01 mock treatment 0.368 0.0115 0.59 0.368 0.0119 0.72 0.9214 0.995 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P02 mock treatment 0.376 0.0195 1.0 0.365 0.00887 0.54 1.0826 0.9577 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P03 compound treatment 0.378 0.0215 1.1 0.359 0.00287 0.17 0.8988 0.8087 1910687 Bionet1_004221 CCOC(=O)Cc1cccc[n+]1Cc2ccc(C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P04 compound treatment 0.381 0.0245 1.25 0.365 0.00887 0.54 1.2634 0.9283 1910688 Bionet1_004222 CCCCCC1CCC(CC1)c2ccc(NC(=O)c3cccs3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P05 compound treatment 0.375 0.0185 0.94 0.383 0.0269 1.62 1.8148 0.9669 1910689 Bionet1_004223 Cc1cc(N/C=C/C(=O)c2ccc(OCCCF)cc2)ccc1Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P06 compound treatment 0.37 0.0135 0.69 0.364 0.00787 0.48 0.823 0.9836 1910690 Bionet1_004224 CCCCCC1CCC(CC1)c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P07 compound treatment 0.376 0.0195 1.0 0.352 -0.00413 -0.25 0.5277 0.5142 1910691 Bionet1_004225 CCOC(=O)Cc1cccc[n+]1Cc2cccc(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P08 compound treatment 0.384 0.0275 1.4 0.374 0.0179 1.08 1.756 0.9915 1910692 Bionet1_004226 CCCCCC1CCC(CC1)c2ccc(NC(=O)Cc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P09 compound treatment 0.395 0.0385 1.97 0.389 0.0329 1.98 2.794 1.0 1910693 Bionet1_004227 Cc1cccc(c1)C(=O)NNc2nc3ccccc3nc2Cc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P10 compound treatment 0.367 0.0105 0.54 0.36 0.00387 0.23 0.5437 0.931 1910694 Bionet1_004228 CCCCCC1CCC(CC1)c2ccc3ncc(C(=O)OCC)c(O)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P11 compound treatment 0.366 0.00947 0.48 0.365 0.00887 0.54 0.721 0.9987 1555455 Bionet1_004229 Cc1ccccc1C(=O)Nc2ncc(I)cc2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P12 compound treatment 0.397 0.0405 2.07 0.389 0.0329 1.98 2.8663 0.9998 1910695 Bionet1_004230 [O-][N+](=O)c1ccc(C/2CCCC\C2=N/OC(=O)Nc3ccccc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P13 compound treatment 0.378 0.0215 1.1 0.365 0.00887 0.54 1.1549 0.9455 1690338 Bionet1_004231 Cc1cc(I)cnc1NC(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P14 compound treatment 0.383 0.0265 1.35 0.379 0.0229 1.38 1.9333 1.0 1292765 Bionet1_004232 Clc1ccc(CNC(=O)c2ccc(OCc3ccccc3)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P15 compound treatment 0.377 0.0205 1.05 0.373 0.0169 1.02 1.4602 0.9999 1349102 Bionet1_004233 COC(=O)c1cc(Br)c(NC(=O)c2ccco2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P16 compound treatment 0.377 0.0205 1.05 0.374 0.0179 1.08 1.5029 0.9999 1910696 Bionet1_004234 CCNC(=O)O/N=C/1\CCCCC1c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P17 compound treatment 0.389 0.0325 1.66 0.389 0.0329 1.98 2.5771 0.9961 1910697 Bionet1_004235 FCCCOc1ccc(cc1)/C(=C/Nc2ccc(Oc3ccccc3)cc2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P18 compound treatment 0.409 0.0525 2.68 0.385 0.0289 1.74 3.1295 0.9782 1910698 Bionet1_004236 COc1cc(Br)cc(/C=N/Cc2cccc(c2)C(F)(F)F)c1O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P19 compound treatment 0.389 0.0325 1.66 0.39 0.0339 2.04 2.6198 0.9947 1910699 Bionet1_004237 FCCCOc1ccc(cc1)/C(=C/Nc2cc(Cl)cc(Cl)c2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P20 compound treatment 0.367 0.0105 0.54 0.367 0.0109 0.66 0.8426 0.9949 1910700 Bionet1_004238 Cc1ccc(cc1)S(=O)(=O)N2C=CC3C2CCC(Br)C3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P21 compound treatment 0.373 0.0165 0.84 0.374 0.0179 1.08 1.3583 0.9925 1910701 Bionet1_004239 COc1cc(N/C=C(\C#N)/c2ccc(OCCCF)cc2)cc(OC)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P22 compound treatment 0.358 0.00147 0.08 0.354 -0.00213 -0.13 -0.0378 -0.2538 1910702 Bionet1_004240 Clc1ccc(C2=Nn3c(nnc3SC2)c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P23 positive control 0.09 -0.267 -13.63 0.101 -0.255 -15.4 -20.5274 -0.9981 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.1235 P24 positive control 0.121 -0.236 -12.04 0.098 -0.258 -15.58 -19.5346 -0.9919 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A01 mock treatment 0.323 -0.0315 -1.61 0.33 -0.0263 -1.59 -2.2607 -1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A02 mock treatment 0.338 -0.0165 -0.84 0.33 -0.0263 -1.59 -1.7184 -0.9558 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A03 compound treatment 0.344 -0.0105 -0.53 0.352 -0.00432 -0.26 -0.5624 -0.9456 1713246 Bionet1_000401 Clc1ccc(Oc2ccc(c3ccnn3c4ccccc4)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A04 compound treatment 0.34 -0.0145 -0.74 0.331 -0.0253 -1.53 -1.6034 -0.9444 1908051 Bionet1_000402 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2cccc(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A05 compound treatment 0.338 -0.0165 -0.84 0.329 -0.0273 -1.65 -1.7611 -0.9512 1333379 Bionet1_000403 Clc1cccc(Cl)c1Cn2cccc(NC(=O)c3ccccc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A06 compound treatment 0.349 -0.00545 -0.28 0.329 -0.0273 -1.65 -1.3634 -0.8151 1908052 Bionet1_000404 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A07 compound treatment 0.339 -0.0155 -0.79 0.327 -0.0293 -1.77 -1.8103 -0.9339 1645116 Bionet1_000405 CC(C)(C)C(=O)Nc1cccn(Cc2c(Cl)cccc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A08 compound treatment 0.345 -0.00945 -0.48 0.324 -0.0323 -1.95 -1.7214 -0.8564 1908053 Bionet1_000406 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2cc(Cl)ccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A09 compound treatment 0.35 -0.00445 -0.23 0.323 -0.0333 -2.01 -1.5833 -0.7821 1908054 Bionet1_000407 FC(F)(F)C(=O)Nc1cccn(Cc2c(Cl)cccc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A10 compound treatment 0.361 0.00655 0.33 0.338 -0.0183 -1.11 -0.5453 -0.4719 1908055 Bionet1_000408 COc1ccc(NC(=O)c2ccc(OS(=O)(=O)N(C)C)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A11 compound treatment 0.354 -4.52E-4 -0.02 0.329 -0.0273 -1.65 -1.1826 -0.7169 1185767 Bionet1_000409 Cc1ccc(cc1)C(=O)Nc2cccn(Cc3c(Cl)cccc3Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A12 compound treatment 0.345 -0.00945 -0.48 0.334 -0.0223 -1.35 -1.2946 -0.9043 1908056 Bionet1_000410 CN(C)S(=O)(=O)Oc1ccccc1C(=O)Nc2ccc(F)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A13 compound treatment 0.334 -0.0205 -1.05 0.335 -0.0213 -1.29 -1.6496 -0.9947 1563361 Bionet1_000411 CCCCC(=O)Nc1cccn(Cc2c(Cl)cccc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A14 compound treatment 0.329 -0.0255 -1.3 0.333 -0.0233 -1.41 -1.9157 -0.9992 1908057 Bionet1_000412 CN(C)S(=O)(=O)Oc1ccccc1C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A15 compound treatment 0.344 -0.0105 -0.53 0.332 -0.0243 -1.47 -1.4161 -0.9063 1525668 Bionet1_000413 CC(C)CC(=O)Nc1cccn(Cc2c(Cl)cccc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A16 compound treatment 0.353 -0.00145 -0.07 0.333 -0.0233 -1.41 -1.048 -0.7434 1908058 Bionet1_000414 CN(C)S(=O)(=O)Oc1ccccc1C(=O)Nc2cccc(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A17 compound treatment 0.349 -0.00545 -0.28 0.33 -0.0263 -1.59 -1.3207 -0.8187 1273797 Bionet1_000415 CCN(CC)C(=O)c1cc(Cl)cn(Cc2c(Cl)cccc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A18 compound treatment 0.358 0.00355 0.18 0.33 -0.0263 -1.59 -0.9953 -0.6223 1908059 Bionet1_000416 CN(C)S(=O)(=O)Oc1ccccc1C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A19 compound treatment 0.341 -0.0135 -0.69 0.331 -0.0253 -1.53 -1.5672 -0.935 1221672 Bionet1_000417 CN(C)CCNC(=O)c1cc(Cl)cn(Cc2ccc(Cl)cc2)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A20 compound treatment 0.356 0.00155 0.08 0.323 -0.0333 -2.01 -1.3664 -0.6788 1908060 Bionet1_000418 COc1ccc(NC(=O)c2ccccc2OS(=O)(=O)N(C)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A21 compound treatment 0.366 0.0115 0.59 0.338 -0.0183 -1.11 -0.3645 -0.2908 1691757 Bionet1_000419 Clc1ccc(NC(=O)c2cn(c3ccccc3)c(=O)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A22 compound treatment 0.362 0.00755 0.39 0.338 -0.0183 -1.11 -0.5092 -0.4346 1908061 Bionet1_000420 Clc1ccc(CO/N=C\NC(=S)Nc2ccccc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A23 positive control 0.083 -0.271 -13.88 0.089 -0.267 -16.14 -21.2257 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 A24 positive control 0.09 -0.264 -13.52 0.093 -0.263 -15.9 -20.8019 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B01 mock treatment 0.365 0.0105 0.54 0.368 0.0117 0.71 0.8799 0.9913 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B02 mock treatment 0.364 0.00955 0.49 0.377 0.0207 1.25 1.2279 0.9161 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B03 compound treatment 0.363 0.00855 0.44 0.355 -0.00132 -0.08 0.2527 0.5687 1908062 Bionet1_000421 Clc1ccc(COn2c(nc3ccccc23)c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B04 compound treatment 0.352 -0.00245 -0.13 0.38 0.0237 1.43 0.9221 0.6426 1602414 Bionet1_000422 Fc1ccccc1c2nnc3c4ccccc4nc(Oc5ccccc5)n23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B05 compound treatment 0.337 -0.0175 -0.89 0.355 -0.00132 -0.08 -0.6874 -0.7673 1908063 Bionet1_000423 Fc1cccc(Cl)c1COn2c(nc3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B06 compound treatment 0.344 -0.0105 -0.53 0.359 0.00268 0.16 -0.2635 -0.472 1908064 Bionet1_000424 Cc1cc(C)cc(COn2c(nc3ncccc23)c4ccc(Cl)cc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B07 compound treatment 0.309 -0.0455 -2.32 0.34 -0.0163 -0.99 -2.3401 -0.927 1908065 Bionet1_000425 FC(F)(F)c1cccc(COn2c(nc3ccccc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B08 compound treatment 0.363 0.00855 0.44 0.363 0.00668 0.4 0.5942 0.9992 1908066 Bionet1_000426 Clc1ccc(/C=N/Nc2nc(Cl)nc3ccccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B09 compound treatment 0.333 -0.0215 -1.1 0.348 -0.00832 -0.5 -1.1308 -0.9373 1908067 Bionet1_000427 Clc1ccc(COn2c(nc3ccccc23)c4ccccc4Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B10 compound treatment 0.37 0.0155 0.8 0.373 0.0167 1.01 1.2741 0.9932 1908068 Bionet1_000428 Clc1nc(N/N=C/c2ccc(Br)cc2)c3ccccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B11 compound treatment 0.368 0.0135 0.69 0.364 0.00768 0.46 0.8176 0.9809 1908069 Bionet1_000429 Clc1ccc(cc1)c2nc3ccccc3n2OCc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B12 compound treatment 0.363 0.00855 0.44 0.367 0.0107 0.64 0.7649 0.9821 1908070 Bionet1_000430 Clc1nc2ccccc2c3nnc(c4ccc(Br)cc4)n13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B13 compound treatment 0.357 0.00255 0.13 0.361 0.00468 0.28 0.2919 0.9383 1908071 Bionet1_000431 Clc1ccc(COn2c(nc3ccccc23)c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B14 compound treatment 0.36 0.00555 0.28 0.363 0.00668 0.4 0.4857 0.9852 1661291 Bionet1_000432 Fc1ccccc1c2nnc3c4ccccc4nc(Nc5ccccc5)n23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B15 compound treatment 0.372 0.0175 0.9 0.366 0.00968 0.58 1.0476 0.9784 1908072 Bionet1_000433 Fc1cccc(Cl)c1COn2c(nc3ccccc23)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B16 compound treatment 0.358 0.00355 0.18 0.366 0.00968 0.58 0.5414 0.885 1908073 Bionet1_000434 Cc1cc(C)cc(COn2c(nc3ccc(Cl)cc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B17 compound treatment 0.351 -0.00345 -0.18 0.361 0.00468 0.28 0.0749 0.2249 1908074 Bionet1_000435 Cc1ccc(cc1)c2nc3ccccc3n2OCc4cccc(c4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B18 compound treatment 0.373 0.0185 0.95 0.399 0.0427 2.58 2.4925 0.9078 1908075 Bionet1_000436 Cn1nc(c(COC(=O)Nc2ccc(Cl)cc2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B19 compound treatment 0.377 0.0225 1.15 0.313 -0.0433 -2.62 -1.034 -0.3618 1908076 Bionet1_000437 Cc1ccc(cc1)c2nc3ccccc3n2OCc4ccc(Cl)cc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B20 compound treatment 0.37 0.0155 0.8 0.363 0.00668 0.4 0.8473 0.9505 1908077 Bionet1_000438 Cn1nc(c(COC(=O)c2ccc(Cl)cc2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B21 compound treatment 0.374 0.0195 1.0 0.367 0.0107 0.64 1.1626 0.9775 1908078 Bionet1_000439 Cc1ccc(cc1)c2nc3ccccc3n2OCc4c(F)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B22 compound treatment 0.365 0.0105 0.54 0.357 6.79E-4 0.04 0.4104 0.7586 1908079 Bionet1_000440 Cn1nc(c(COC(=O)Nc2cccc(Cl)c2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B23 positive control 0.084 -0.27 -13.83 0.086 -0.27 -16.32 -21.3176 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 B24 positive control 0.087 -0.267 -13.68 0.09 -0.266 -16.08 -21.0384 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C01 mock treatment 0.368 0.0135 0.69 0.364 0.00768 0.46 0.8176 0.9809 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C02 mock treatment 0.351 -0.00345 -0.18 0.373 0.0167 1.01 0.5872 0.5744 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C03 compound treatment 0.371 0.0165 0.85 0.365 0.00868 0.52 0.9688 0.9734 1134484 Bionet1_000441 Clc1ccc(NC(=O)c2cn(Cc3cccnc3)c(=O)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C04 compound treatment 0.419 0.0645 3.3 0.43 0.0737 4.45 5.4789 0.9892 1908080 Bionet1_000442 CS/C(=C(/C(=O)\C=C\c1ccccc1)\c2ccccc2)/Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C05 compound treatment 0.353 -0.00145 -0.07 0.367 0.0107 0.64 0.4034 0.6216 1908081 Bionet1_000443 FC(F)(F)Oc1ccc(NNC(=O)c2c(Cl)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C06 compound treatment 0.374 0.0195 1.0 0.37 0.0137 0.83 1.2907 0.9955 1908082 Bionet1_000444 COc1ccc(cc1)C2CC(=O)C(=C(Nc3ccccc3)S2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C07 compound treatment 0.379 0.0245 1.26 0.375 0.0187 1.13 1.6849 0.9986 1908083 Bionet1_000445 FC(F)(F)Oc1ccc(NNC(=O)c2ccc(Cl)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C08 compound treatment 0.367 0.0125 0.64 0.366 0.00968 0.58 0.8668 0.9989 1908084 Bionet1_000446 Cc1ccc(cc1)C2CC(=O)C(=C(Nc3ccccc3)S2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C09 compound treatment 0.366 0.0115 0.59 0.361 0.00468 0.28 0.6173 0.943 1908085 Bionet1_000447 FC(F)(F)Oc1ccc(NNC(=O)c2ccccc2C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C10 compound treatment 0.377 0.0225 1.15 0.372 0.0157 0.95 1.4845 0.9952 1908086 Bionet1_000448 FC(F)(F)c1nnc2c(Sc3ccccc3)nc4ccc(Cl)cc4n12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C11 compound treatment 0.37 0.0155 0.8 0.361 0.00468 0.28 0.7619 0.903 1732143 Bionet1_000449 CC(C)OC(=O)c1cc(Cl)c(=O)n(Cc2ccc(Cl)cc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C12 compound treatment 0.367 0.0125 0.64 0.356 -3.21E-4 -0.02 0.44 0.6854 1908087 Bionet1_000450 C1CN(CCN1C(c2ccccc2)c3ccccc3)C4=Nc5ccccc5CS4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C13 compound treatment 0.373 0.0185 0.95 0.37 0.0137 0.83 1.2545 0.9976 1908088 Bionet1_000451 CCCCOC(=O)c1cc(Cl)c(=O)n(Cc2ccc(Cl)cc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C14 compound treatment 0.369 0.0145 0.74 0.355 -0.00132 -0.08 0.4696 0.6277 1908089 Bionet1_000452 CN(C)S(=O)(=O)Oc1ccccc1C(=O)Nc2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C15 compound treatment 0.37 0.0155 0.8 0.364 0.00768 0.46 0.8899 0.967 1206331 Bionet1_000453 Clc1ccc(Cn2cc(cc(Cl)c2=O)C(=O)OCC#C)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C16 compound treatment 0.365 0.0105 0.54 0.357 6.79E-4 0.04 0.4104 0.7586 1908090 Bionet1_000454 CN(C)S(=O)(=O)Oc1ccccc1C(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C17 compound treatment 0.37 0.0155 0.8 0.36 0.00368 0.22 0.7192 0.8713 1241150 Bionet1_000455 Clc1ccc(C(=O)Oc2cccnc2I)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C18 compound treatment 0.372 0.0175 0.9 0.371 0.0147 0.89 1.2611 1.0 1908091 Bionet1_000456 CN(C)S(=O)(=O)Oc1ccccc1C(=O)Nc2ccc(cc2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C19 compound treatment 0.436 0.0815 4.17 0.424 0.0677 4.09 5.8375 0.9999 1908092 Bionet1_000457 [O-][N+](=O)c1ccc(NC(=O)Oc2cccnc2I)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C20 compound treatment 0.354 -4.52E-4 -0.02 0.348 -0.00832 -0.5 -0.3715 -0.7388 1908093 Bionet1_000458 CN(C)S(=O)(=O)Oc1cccc(c1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C21 compound treatment 0.361 0.00655 0.33 0.36 0.00368 0.22 0.3938 0.9801 1908094 Bionet1_000459 [O-][N+](=O)c1ccc(CONC(=O)N/C=N/OCc2ccc(cc2)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C22 compound treatment 0.361 0.00655 0.33 0.356 -3.21E-4 -0.02 0.223 0.665 1908095 Bionet1_000460 CN(C)S(=O)(=O)Oc1cccc(c1)C(=O)Nc2cccc(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C23 positive control 0.083 -0.271 -13.88 0.085 -0.271 -16.38 -21.3965 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 C24 positive control 0.087 -0.267 -13.68 0.089 -0.267 -16.14 -21.0811 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D01 mock treatment 0.139 -0.215 -11.02 0.353 -0.00332 -0.2 -7.9317 -0.7199 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D02 mock treatment 0.357 0.00255 0.13 0.359 0.00268 0.16 0.2065 0.9943 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D03 compound treatment 0.35 -0.00445 -0.23 0.343 -0.0133 -0.8 -0.7296 -0.873 1908096 Bionet1_000461 COc1ccc(cc1)c2nc3ccccc3n2OCc4c(Cl)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D04 compound treatment 0.356 0.00155 0.08 0.358 0.00168 0.1 0.1276 0.9925 1908097 Bionet1_000462 Cc1ccc(COn2c(nc3ccc(cc23)[N+](=O)[O-])c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D05 compound treatment 0.327 -0.0275 -1.4 0.363 0.00668 0.4 -0.7075 -0.4844 1908098 Bionet1_000463 COc1ccc(cc1)c2nc3ccccc3n2OCc4ccc(Cl)c(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D06 compound treatment 0.362 0.00755 0.39 0.36 0.00368 0.22 0.4299 0.9655 1908099 Bionet1_000464 Cc1cc(C)cc(COn2c(nc3ccc(cc23)[N+](=O)[O-])c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D07 compound treatment 0.38 0.0255 1.31 0.363 0.00668 0.4 1.2088 0.8842 1590670 Bionet1_000465 COC(=O)c1nn(c2ccccc2)c(=O)cc1Sc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D08 compound treatment 0.353 -0.00145 -0.07 0.342 -0.0143 -0.86 -0.6638 -0.765 1908100 Bionet1_000466 CCOC(=O)C(C)On1c(nc2ccc(cc12)[N+](=O)[O-])c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D09 compound treatment 0.36 0.00555 0.28 0.357 6.79E-4 0.04 0.2296 0.8009 1141529 Bionet1_000467 COC(=O)c1nn(c2ccc(OC)cc2)c(=O)cc1Sc3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D10 compound treatment 0.35 -0.00445 -0.23 0.354 -0.00232 -0.14 -0.26 -0.9729 1908101 Bionet1_000468 Cc1ccc(COn2c(nc3ccc(cc23)[N+](=O)[O-])c4cccc(Cl)c4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D11 compound treatment 0.364 0.00955 0.49 0.366 0.00968 0.58 0.7584 0.996 1908102 Bionet1_000469 COC(=O)c1sc2cc(=O)n(nc2c1O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D12 compound treatment 0.345 -0.00945 -0.48 0.354 -0.00232 -0.14 -0.4408 -0.8761 1908103 Bionet1_000470 CCOC(=O)CSc1nc(Cc2ccc(Cl)cc2)nc3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D13 compound treatment 0.359 0.00455 0.23 0.353 -0.00332 -0.2 0.0227 0.0738 1310906 Bionet1_000471 COC(=O)c1nn(c2ccc(OC)cc2)c(=O)cc1Sc3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D14 compound treatment 0.357 0.00255 0.13 0.353 -0.00332 -0.2 -0.0496 -0.2076 1728366 Bionet1_000472 Clc1ccc(Cc2nc(NCc3ccccc3)c4ccccc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D15 compound treatment 0.363 0.00855 0.44 0.374 0.0177 1.07 1.0637 0.9224 1330713 Bionet1_000473 COC(=O)CSc1cc(=O)n(nc1C(=O)OC)c2ccc(OC)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D16 compound treatment 0.362 0.00755 0.39 0.355 -0.00132 -0.08 0.2165 0.5493 1663469 Bionet1_000474 Clc1ccc(c2nnc3c4ccccc4nc(N5CCCCC5)n23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D17 compound treatment 0.355 5.48E-4 0.03 0.371 0.0147 0.89 0.6464 0.7291 1908104 Bionet1_000475 COC(=O)c1sc2cc(=O)n(nc2c1N)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D18 compound treatment 0.372 0.0175 0.9 0.364 0.00768 0.46 0.9623 0.9528 1700185 Bionet1_000476 Clc1ccc(cc1Cl)c2nnc3c4ccccc4nc(N5CCOCC5)n23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D19 compound treatment 0.359 0.00455 0.23 0.361 0.00468 0.28 0.3642 0.9953 1489949 Bionet1_000477 COC(=O)c1nn(c2ccc(OC)cc2)c(=O)cc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D20 compound treatment 0.363 0.00855 0.44 0.363 0.00668 0.4 0.5942 0.9992 1908105 Bionet1_000478 CN1C(=O)N(C)C(=O)C(=CNNc2ncc(cc2Cl)C(F)(F)F)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D21 compound treatment 0.377 0.0225 1.15 0.368 0.0117 0.71 1.3138 0.9721 1625642 Bionet1_000479 COc1ccc(cc1)n2nc(C(=O)NN)c(Sc3ccc(C)cc3)cc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D22 compound treatment 0.36 0.00555 0.28 0.363 0.00668 0.4 0.4857 0.9852 1908106 Bionet1_000480 Cc1snc(SCc2ncc(cc2Cl)C(F)(F)F)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D23 positive control 0.083 -0.271 -13.88 0.085 -0.271 -16.38 -21.3965 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 D24 positive control 0.088 -0.266 -13.62 0.091 -0.265 -16.02 -20.9596 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E01 mock treatment 0.363 0.00855 0.44 0.305 -0.0513 -3.1 -1.8817 -0.6014 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E02 mock treatment 0.357 0.00255 0.13 0.362 0.00568 0.34 0.3345 0.9122 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E03 compound treatment 0.371 0.0165 0.85 0.379 0.0227 1.37 1.5664 0.9733 1908107 Bionet1_000481 Clc1ccc(NC(=O)c2cc(Cl)c(=O)n(Cc3ccccc3)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E04 compound treatment 0.337 -0.0175 -0.89 0.359 0.00268 0.16 -0.5166 -0.5697 1908108 Bionet1_000482 CN(C)S(=O)(=O)Oc1cccc(c1)C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E05 compound treatment 0.35 -0.00445 -0.23 0.354 -0.00232 -0.14 -0.26 -0.9729 1657485 Bionet1_000483 Clc1cc(cn(Cc2ccccc2)c1=O)C(=O)NCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E06 compound treatment 0.339 -0.0155 -0.79 0.337 -0.0193 -1.17 -1.3834 -0.982 1908109 Bionet1_000484 CN(C)S(=O)(=O)Oc1cccc(c1)C(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E07 compound treatment 0.351 -0.00345 -0.18 0.352 -0.00432 -0.26 -0.3093 -0.9819 1712706 Bionet1_000485 Fc1ccc(NC(=O)c2cc(Cl)c(=O)n(Cc3ccccc3)c2)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E08 compound treatment 0.357 0.00255 0.13 0.354 -0.00232 -0.14 -0.007 -0.0363 1908110 Bionet1_000486 CN(C)S(=O)(=O)Oc1cccc(c1)C(=O)Nc2ccc(F)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E09 compound treatment 0.387 0.0325 1.66 0.379 0.0227 1.37 2.1449 0.9953 1169784 Bionet1_000487 Clc1ccc(Cn2cc(cc(Cl)c2=O)C(=O)Nc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E10 compound treatment 0.366 0.0115 0.59 0.366 0.00968 0.58 0.8307 1.0 1908111 Bionet1_000488 COc1ccc(NC(=O)c2cccc(OS(=O)(=O)N(C)C)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E11 compound treatment 0.371 0.0165 0.85 0.36 0.00368 0.22 0.7554 0.8634 1447132 Bionet1_000489 Clc1ccc(Cn2cc(cc(Cl)c2=O)C(=O)NCc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E12 compound treatment 0.357 0.00255 0.13 0.352 -0.00432 -0.26 -0.0923 -0.3166 1908112 Bionet1_000490 CN(C)S(=O)(=O)Oc1cccc(c1)C(=O)Nc2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E13 compound treatment 0.37 0.0155 0.8 0.35 -0.00632 -0.38 0.2923 0.3315 1442566 Bionet1_000491 CN(C)CCNC(=O)c1cc(Cl)c(=O)n(Cc2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E14 compound treatment 0.375 0.0205 1.05 0.36 0.00368 0.22 0.9 0.838 1908113 Bionet1_000492 CN(C)S(=O)(=O)Oc1ccc(cc1Cl)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E15 compound treatment 0.378 0.0235 1.2 0.362 0.00568 0.34 1.0938 0.8737 1666594 Bionet1_000493 Clc1ccc(Cn2cc(cc(Cl)c2=O)C(=O)N3CCOCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E16 compound treatment 0.379 0.0245 1.26 0.361 0.00468 0.28 1.0873 0.8451 1908114 Bionet1_000494 CN(C)S(=O)(=O)Oc1ccc(cc1Cl)C(=O)Nc2cccc(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E17 compound treatment 0.392 0.0375 1.92 0.365 0.00868 0.52 1.7281 0.8683 1644458 Bionet1_000495 CN1CCN(CC1)C(=O)c2cc(Cl)c(=O)n(Cc3ccc(Cl)cc3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E18 compound treatment 0.366 0.0115 0.59 0.357 6.79E-4 0.04 0.4465 0.7543 1908115 Bionet1_000496 CN(C)S(=O)(=O)Oc1ccc(cc1Cl)C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E19 compound treatment 0.4 0.0455 2.33 0.396 0.0397 2.4 3.3406 0.9999 1517230 Bionet1_000497 Clc1ccc(NC(=O)CC(=O)Nc2ccc(Cl)cc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E20 compound treatment 0.364 0.00955 0.49 0.362 0.00568 0.34 0.5876 0.985 1908116 Bionet1_000498 CN(C)S(=O)(=O)Oc1ccc(Cl)cc1C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E21 compound treatment 0.37 0.0155 0.8 0.367 0.0107 0.64 1.018 0.9946 1908117 Bionet1_000499 CNC(=S)NNC(=O)c1cccn(Cc2cccc(c2)C(F)(F)F)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E22 compound treatment 0.367 0.0125 0.64 0.366 0.00968 0.58 0.8668 0.9989 1908118 Bionet1_000500 FC(F)(F)c1nnc2c(Sc3ccc(Cl)cc3)nc4ccccc4n12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E23 positive control 0.084 -0.27 -13.83 0.088 -0.268 -16.2 -21.2323 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 E24 positive control 0.088 -0.266 -13.62 0.095 -0.261 -15.78 -20.7888 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F01 mock treatment 0.364 0.00955 0.49 0.236 -0.12 -7.26 -4.7909 -0.6581 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F02 mock treatment 0.343 -0.0115 -0.59 0.351 -0.00532 -0.32 -0.6412 -0.9601 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F03 compound treatment 0.365 0.0105 0.54 0.367 0.0107 0.64 0.8372 0.9961 1908119 Bionet1_000501 COC(=O)c1nn(c2cccc(c2)C(F)(F)F)c(=O)cc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F04 compound treatment 0.394 0.0395 2.02 0.387 0.0307 1.85 2.7395 0.999 1908120 Bionet1_000502 CC(C)C(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)c(Cl)c2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F05 compound treatment 0.353 -0.00145 -0.07 0.362 0.00568 0.34 0.1899 0.5415 1726222 Bionet1_000503 COC(=O)c1nn(c2ccc(Cl)cc2)c(=O)cc1Oc3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F06 compound treatment 0.352 -0.00245 -0.13 0.347 -0.00932 -0.56 -0.4865 -0.8439 1908121 Bionet1_000504 FC(F)(F)c1cccc(CN2C(=O)/C(=N\OC(=O)C3CC3)/c4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F07 compound treatment 0.378 0.0235 1.2 0.371 0.0147 0.89 1.478 0.9886 1658078 Bionet1_000505 COC(=O)c1nn(c2ccc(OC)cc2)c(=O)cc1Oc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F08 compound treatment 0.369 0.0145 0.74 0.356 -3.21E-4 -0.02 0.5123 0.6884 1908122 Bionet1_000506 ClCC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2Cl)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F09 compound treatment 0.364 0.00955 0.49 0.361 0.00468 0.28 0.5449 0.9661 1622633 Bionet1_000507 COC(=O)c1nn(c2ccc(Cl)cc2)c(=O)cc1Sc3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F10 compound treatment 0.404 0.0495 2.53 0.407 0.0507 3.06 3.9548 0.9956 1908123 Bionet1_000508 CC(C)C(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2Cl)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F11 compound treatment 0.38 0.0255 1.31 0.373 0.0167 1.01 1.6357 0.9917 1247584 Bionet1_000509 Clc1ccc(c(Cl)c1)n2nc(C#N)c(Oc3ccccc3)cc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F12 compound treatment 0.395 0.0405 2.07 0.376 0.0197 1.19 2.3061 0.9651 1908124 Bionet1_000510 CCC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2Cl)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F13 compound treatment 0.375 0.0205 1.05 0.369 0.0127 0.77 1.2842 0.9879 1140024 Bionet1_000511 COC(=O)c1nn(c2ccc(Cl)cc2)c(=O)cc1Oc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F14 compound treatment 0.371 0.0165 0.85 0.359 0.00268 0.16 0.7127 0.8273 1908125 Bionet1_000512 N/C(=N\Nc1ncc(cc1Cl)C(F)(F)F)/CSc2ccccn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F15 compound treatment 0.405 0.0505 2.58 0.387 0.0307 1.85 3.1372 0.9866 1720398 Bionet1_000513 COC(=O)c1nn(c2ccc(Cl)cc2)c(=O)cc1Sc3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F16 compound treatment 0.398 0.0435 2.23 0.376 0.0197 1.19 2.4146 0.9567 1908126 Bionet1_000514 Fc1cccc(Cl)c1COn2c(nc3ccc(Cl)cc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F17 compound treatment 0.394 0.0395 2.02 0.376 0.0197 1.19 2.2699 0.9679 1273407 Bionet1_000515 COC(=O)c1nn(c2ccccc2)c(=O)cc1Oc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F18 compound treatment 0.38 0.0255 1.31 0.37 0.0137 0.83 1.5076 0.9755 1908127 Bionet1_000516 Cc1ccc(CN2C(=O)/C(=N\OC(=O)CCCCl)/c3ccccc23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F19 compound treatment 0.358 0.00355 0.18 0.374 0.0177 1.07 0.8829 0.8156 1368159 Bionet1_000517 COC(=O)c1nn(c2ccc(Cl)cc2)c(=O)cc1Sc3ncccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F20 compound treatment 0.361 0.00655 0.33 0.377 0.0207 1.25 1.1195 0.8662 1908128 Bionet1_000518 CC(C)CC(=O)O/N=C/1\C(=O)N(Cc2ccc(C)cc2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F21 compound treatment 0.36 0.00555 0.28 0.374 0.0177 1.07 0.9553 0.865 1908129 Bionet1_000519 COC(=O)c1nn(c2ccc(Cl)cc2)c(=O)cc1Sc3cccc[n+]3[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F22 compound treatment 0.376 0.0215 1.1 0.373 0.0167 1.01 1.4911 0.999 1908130 Bionet1_000520 CCCCC(=O)O/N=C/1\C(=O)N(Cc2ccc(C)cc2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F23 positive control 0.087 -0.267 -13.68 0.086 -0.27 -16.32 -21.2092 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 F24 positive control 0.087 -0.267 -13.68 0.092 -0.264 -15.96 -20.953 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G01 mock treatment 0.352 -0.00245 -0.13 0.354 -0.00232 -0.14 -0.1877 -0.9985 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G02 mock treatment 0.362 0.00755 0.39 0.358 0.00168 0.1 0.3446 0.8635 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G03 compound treatment 0.348 -0.00645 -0.33 0.356 -3.21E-4 -0.02 -0.247 -0.7474 1908131 Bionet1_000521 CNC(=S)NNC(=O)c1cccn(Cc2ccc(Cl)c(Cl)c2)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G04 compound treatment 0.352 -0.00245 -0.13 0.369 0.0127 0.77 0.4526 0.5835 1908132 Bionet1_000522 COc1ccc(Sc2nc3ccccc3n4c(nnc24)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G05 compound treatment 0.342 -0.0125 -0.64 0.361 0.00468 0.28 -0.2505 -0.3596 1908133 Bionet1_000523 Cn1c(S)nnc1c2cccn(Cc3cccc(c3)C(F)(F)F)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G06 compound treatment 0.36 0.00555 0.28 0.365 0.00868 0.52 0.5711 0.9585 1908134 Bionet1_000524 Nc1c(cnn1c2ccc(Cc3ccc(Cl)cc3Cl)nn2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G07 compound treatment 0.344 -0.0105 -0.53 0.35 -0.00632 -0.38 -0.6477 -0.9864 1908135 Bionet1_000525 Cn1c(S)nnc1c2cccn(Cc3ccc(Cl)c(Cl)c3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G08 compound treatment 0.365 0.0105 0.54 0.369 0.0127 0.77 0.9226 0.9853 1117855 Bionet1_000526 COc1ccc(NC(=O)c2cccn(Cc3ccccc3Cl)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G09 compound treatment 0.372 0.0175 0.9 0.357 6.79E-4 0.04 0.6634 0.7386 1908136 Bionet1_000527 CNC(=S)NNC(=O)c1cccn(Cc2ccc(Cl)cc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G10 compound treatment 0.397 0.0425 2.18 0.375 0.0187 1.13 2.3357 0.9532 1471885 Bionet1_000528 COc1ccc(NC(=O)c2cccn(Cc3ccccc3Cl)c2=O)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G11 compound treatment 0.378 0.0235 1.2 0.359 0.00268 0.16 0.9658 0.7949 1908137 Bionet1_000529 CCNC(=S)NNC(=O)c1cccn(Cc2ccc(Cl)cc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G12 compound treatment 0.357 0.00255 0.13 0.349 -0.00732 -0.44 -0.2204 -0.4783 1908138 Bionet1_000530 Cn1nc(c(/C=N/O)c1SCc2ccccc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G13 compound treatment 0.392 0.0375 1.92 0.372 0.0157 0.95 2.0269 0.9469 1599000 Bionet1_000531 CCn1c(S)nnc1c2cccn(Cc3ccc(Cl)cc3Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G14 compound treatment 0.362 0.00755 0.39 0.341 -0.0153 -0.92 -0.3811 -0.3803 1908139 Bionet1_000532 Cn1nc(c(/C=N/O)c1SCc2ccc(Cl)cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G15 compound treatment 0.376 0.0215 1.1 0.352 -0.00432 -0.26 0.5946 0.5252 1553217 Bionet1_000533 Sc1nnc(c2cccn(Cc3ccc(Cl)cc3Cl)c2=O)n1CC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G16 compound treatment 0.351 -0.00345 -0.18 0.365 0.00868 0.52 0.2457 0.4444 1908140 Bionet1_000534 Cn1nc(c(/C=N/O)c1SCc2ccc(cc2)C(C)(C)C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G17 compound treatment 0.389 0.0345 1.77 0.37 0.0137 0.83 1.833 0.94 1908141 Bionet1_000535 CSc1nnc(c2cccn(Cc3ccc(Cl)cc3Cl)c2=O)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G18 compound treatment 0.386 0.0315 1.61 0.373 0.0167 1.01 1.8526 0.9743 1908142 Bionet1_000536 CO/N=C/c1c(Sc2ccccc2C(=O)OC)n(C)nc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G19 compound treatment 0.447 0.0925 4.73 0.423 0.0667 4.03 6.1925 0.9968 1908143 Bionet1_000537 [O-][N+](=O)/C(=C/Nc1cc(Cl)cc(Cl)c1)/C2OC(=O)c3ccccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G20 compound treatment 0.392 0.0375 1.92 0.376 0.0197 1.19 2.1976 0.9734 1908144 Bionet1_000538 COC(=O)c1ccccc1Sc2c(/C=N/O)c(nn2C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G21 compound treatment 0.393 0.0385 1.97 0.391 0.0347 2.09 2.8741 0.9995 1908145 Bionet1_000539 [O-][N+](=O)/C(=C/Nc1cccc(c1)C(F)(F)F)/C2OC(=O)c3ccccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G22 compound treatment 0.372 0.0175 0.9 0.378 0.0217 1.31 1.5599 0.9831 1703282 Bionet1_000540 Clc1ccc(cc1)C(=O)NCC(=O)N2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G23 positive control 0.086 -0.268 -13.73 0.091 -0.265 -16.02 -21.0319 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 G24 positive control 0.089 -0.265 -13.57 0.098 -0.258 -15.59 -20.6246 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H01 mock treatment 0.367 0.0125 0.64 0.324 -0.0323 -1.95 -0.926 -0.4508 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H02 mock treatment 0.342 -0.0125 -0.64 0.366 0.00968 0.58 -0.0371 -0.0429 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H03 compound treatment 0.363 0.00855 0.44 0.348 -0.00832 -0.5 -0.0461 -0.0693 1908146 Bionet1_000541 C/C(=C/C(=O)c1c(C)nn(c1O)c2nc(cs2)c3ccc(C)cc3)/O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H04 compound treatment 0.34 -0.0145 -0.74 0.366 0.00968 0.58 -0.1094 -0.1161 1908147 Bionet1_000542 Cc1ccc(CN2C(=O)/C(=N\OC(=O)C(C)(C)CCl)/c3ccccc23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H05 compound treatment 0.359 0.00455 0.23 0.359 0.00268 0.16 0.2788 0.9842 1908148 Bionet1_000543 Cc1cc(c2c(C)nn(c2O)c3ccccc3)n(n1)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H06 compound treatment 0.352 -0.00245 -0.13 0.358 0.00168 0.1 -0.017 -0.1054 1908149 Bionet1_000544 ClCC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H07 compound treatment 0.364 0.00955 0.49 0.361 0.00468 0.28 0.5449 0.9661 1908150 Bionet1_000545 Cc1cc(c2c(C)nn(c2O)c3ccc(Cl)cc3)n(n1)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H08 compound treatment 0.359 0.00455 0.23 0.355 -0.00132 -0.08 0.108 0.4394 1908151 Bionet1_000546 ClCCCC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H09 compound treatment 0.365 0.0105 0.54 0.368 0.0117 0.71 0.8799 0.9913 1908152 Bionet1_000547 COc1ccc(cc1)c2csc(n2)n3nc(C)c(C(=O)/C=C(/C)\O)c3O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H10 compound treatment 0.378 0.0235 1.2 0.378 0.0217 1.31 1.7768 0.9991 1908153 Bionet1_000548 CC(C)CC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H11 compound treatment 0.369 0.0145 0.74 0.361 0.00468 0.28 0.7257 0.9121 1908154 Bionet1_000549 Cc1cc(c2c(C)nn(c2O)c3ccc(Cl)cc3)n(n1)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H12 compound treatment 0.398 0.0435 2.23 0.395 0.0387 2.33 3.2256 0.9997 1908155 Bionet1_000550 [O-][N+](=O)c1ccc2N(Cc3ccc(Cl)cc3Cl)C(=O)C(=O)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H13 compound treatment 0.38 0.0255 1.31 0.371 0.0147 0.89 1.5503 0.9821 1908156 Bionet1_000551 Cc1cc(c2c(C)nn(c2O)c3nc(cs3)c4ccccc4)n(n1)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H14 compound treatment 0.37 0.0155 0.8 0.378 0.0217 1.31 1.4876 0.9715 1908157 Bionet1_000552 CCCCC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H15 compound treatment 0.375 0.0205 1.05 0.376 0.0197 1.19 1.583 0.9981 1908158 Bionet1_000553 C/C(=C/C(=O)c1c(C)nn(c1O)c2nc(cs2)c3ccc(Cl)cc3)/O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H16 compound treatment 0.38 0.0255 1.31 0.377 0.0207 1.25 1.8064 0.9997 1908159 Bionet1_000554 FC(F)(F)c1cnc(N2CCN(CC2)c3ccc(Cl)nn3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H17 compound treatment 0.347 -0.00745 -0.38 0.363 0.00668 0.4 0.0157 0.0282 1908160 Bionet1_000555 COc1ccc(cc1)c2nc3ccccc3n2OCc4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H18 compound treatment 0.377 0.0225 1.15 0.369 0.0127 0.77 1.3565 0.9802 1908161 Bionet1_000556 O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2Cl)c3ccc(cc13)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H19 compound treatment 0.346 -0.00845 -0.43 0.377 0.0207 1.25 0.5771 0.4369 1908162 Bionet1_000557 COc1ccc(cc1)c2nc3ccccc3n2OCc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H20 compound treatment 0.368 0.0135 0.69 0.377 0.0207 1.25 1.3726 0.9614 1908163 Bionet1_000558 CCCCC(=O)O/N=C/1\C(=O)N(Cc2cccc(Cl)c2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H21 compound treatment 0.361 0.00655 0.33 0.362 0.00568 0.34 0.4792 0.9999 1908164 Bionet1_000559 COc1ccc(cc1)c2nc3ccccc3n2OCc4c(F)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H22 compound treatment 0.318 -0.0365 -1.86 0.307 -0.0493 -2.98 -3.4233 -0.9746 1908165 Bionet1_000560 ClCCC(=O)O/N=C/1\C(=O)N(Cc2cccc(Cl)c2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H23 positive control 0.085 -0.269 -13.78 0.092 -0.264 -15.96 -21.0254 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 H24 positive control 0.087 -0.267 -13.68 0.102 -0.254 -15.35 -20.5262 -0.9983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I01 mock treatment 0.351 -0.00345 -0.18 0.359 0.00268 0.16 -0.0105 -0.0437 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I02 mock treatment 0.353 -0.00145 -0.07 0.366 0.00968 0.58 0.3607 0.6124 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I03 compound treatment 0.591 0.237 12.1 0.575 0.219 13.2 17.8874 0.999 1908166 Bionet1_000561 [O-][N+](=O)/C(=C/Nc1ccc(Oc2ccccc2)cc1)/C3OC(=O)c4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I04 compound treatment 0.339 -0.0155 -0.79 0.342 -0.0143 -0.86 -1.17 -0.999 1908167 Bionet1_000562 COc1ccc(cc1)C(=O)NCC(=O)NCCOC(=O)c2ccccc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I05 compound treatment 0.363 0.00855 0.44 0.372 0.0157 0.95 0.9783 0.9384 1908168 Bionet1_000563 Clc1ccc(CO/N=C/NC(=O)C2CCN(CC2)c3ncccn3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I06 compound treatment 0.443 0.0885 4.53 0.428 0.0717 4.33 6.2613 0.9997 1908169 Bionet1_000564 CC/1=NN(C(=O)\C1=N/Nc2cccc(c2)C(F)(F)F)C3=NCCS3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I07 compound treatment 0.4 0.0455 2.33 0.387 0.0307 1.85 2.9564 0.9936 1908170 Bionet1_000565 CC(C)(C)c1ccc(N/C=C(\C2OC(=O)c3ccccc23)/[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I08 compound treatment 0.358 0.00355 0.18 0.356 -3.21E-4 -0.02 0.1146 0.6279 1908171 Bionet1_000566 Clc1ccc(cc1Cl)N2C(=O)CSC23C(=O)Nc4ccccc43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I09 compound treatment 0.372 0.0175 0.9 0.366 0.00968 0.58 1.0476 0.9784 1908172 Bionet1_000567 Clc1cccc(Cn2cc(Cl)cc(C(=O)Nc3ccccc3)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I10 compound treatment 0.367 0.0125 0.64 0.367 0.0107 0.64 0.9095 1.0 1908173 Bionet1_000568 FC(F)(F)c1cccc(c1)N2C(=O)CSC23C(=O)Nc4ccccc43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I11 compound treatment 0.365 0.0105 0.54 0.36 0.00368 0.22 0.5384 0.9231 1908174 Bionet1_000569 Clc1ccc(cc1)C(=O)C[n+]2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I12 compound treatment 0.378 0.0235 1.2 0.358 0.00168 0.1 0.9231 0.7639 1333462 Bionet1_000570 O=C1CSC2(N1c3ccccc3)C(=O)N(Cc4ccccc4)c5ccccc52 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I13 compound treatment 0.362 0.00755 0.39 0.358 0.00168 0.1 0.3446 0.8635 1908175 Bionet1_000571 Clc1ccc(C(=O)C[n+]2ccccc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I14 compound treatment 0.385 0.0305 1.56 0.375 0.0187 1.13 1.9018 0.9872 1908176 Bionet1_000572 Clc1ccc(cc1)n2cc(COC(=O)Nc3cccc(Cl)c3)nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I15 compound treatment 0.359 0.00455 0.23 0.353 -0.00332 -0.2 0.0227 0.0738 1003505 Bionet1_000573 [O-][N+](=O)c1ccc(cc1)C(=O)C[n+]2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I16 compound treatment 0.382 0.0275 1.41 0.368 0.0117 0.71 1.4946 0.9488 1908177 Bionet1_000574 FC(F)(F)c1cccc(NC(=O)OCc2cn(nn2)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I17 compound treatment 0.381 0.0265 1.36 0.364 0.00768 0.46 1.2877 0.8977 1908178 Bionet1_000575 CNC(=S)NNC(=O)c1ccc(=O)n(Cc2cccc(c2)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I18 compound treatment 0.401 0.0465 2.38 0.371 0.0147 0.89 2.3096 0.9094 1908179 Bionet1_000576 Clc1ccc(NC(=O)OCc2cn(nn2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I19 compound treatment 0.408 0.0535 2.74 0.387 0.0307 1.85 3.2457 0.9819 1908180 Bionet1_000577 FC(F)(F)c1cccc(Cn2cc(ccc2=O)c3nnc(S)n3CC=C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I20 compound treatment 0.356 0.00155 0.08 0.363 0.00668 0.4 0.3411 0.8301 1908181 Bionet1_000578 Clc1ccc(cc1)n2cc(COC(=O)C(Cl)(Cl)Cl)nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I21 compound treatment 0.348 -0.00645 -0.33 0.367 0.0107 0.64 0.2226 0.3074 1908182 Bionet1_000579 FC(F)(F)c1cccc(Cn2cc(ccc2=O)c3nnc(S)o3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I22 compound treatment 0.397 0.0425 2.18 0.387 0.0307 1.85 2.848 0.9968 1908183 Bionet1_000580 Clc1ccc(cc1)n2cc(COC(=O)c3ccc(Cl)cc3Cl)nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I23 positive control 0.083 -0.271 -13.88 0.09 -0.266 -16.08 -21.183 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 I24 positive control 0.086 -0.268 -13.73 0.094 -0.262 -15.84 -20.9038 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J01 mock treatment 0.352 -0.00245 -0.13 0.329 -0.0273 -1.65 -1.2549 -0.7587 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J02 mock treatment 0.362 0.00755 0.39 0.359 0.00268 0.16 0.3873 0.9254 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J03 compound treatment 0.319 -0.0355 -1.81 0.343 -0.0133 -0.8 -1.8504 -0.9331 1908184 Bionet1_000581 COc1ccc(cc1)c2nc3ccccc3n2OCc4cccc(c4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J04 compound treatment 0.358 0.00355 0.18 0.37 0.0137 0.83 0.7122 0.8424 1908185 Bionet1_000582 Cc1ccc(cc1)S(=O)(=O)Nc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J05 compound treatment 0.353 -0.00145 -0.07 0.36 0.00368 0.22 0.1045 0.4465 1908186 Bionet1_000583 Clc1ccc(cc1)c2nc3ncccc3n2OCc4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J06 compound treatment 0.381 0.0265 1.36 0.379 0.0227 1.37 1.928 1.0 1908187 Bionet1_000584 CC(=O)N(OCc1ccc(Cl)cc1)/C=C\2/N=C(OC2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J07 compound treatment 0.361 0.00655 0.33 0.38 0.0237 1.43 1.2475 0.8497 1726544 Bionet1_000585 Clc1ccc(COn2c(nc3ncccc23)c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J08 compound treatment 0.373 0.0185 0.95 0.362 0.00568 0.34 0.913 0.9054 1908188 Bionet1_000586 FC(F)(F)c1cnc(OCCNC(=O)Cc2ccccc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J09 compound treatment 0.369 0.0145 0.74 0.371 0.0147 0.89 1.1526 0.9962 1908189 Bionet1_000587 FC(F)(F)c1cccc(COn2c(nc3ncccc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J10 compound treatment 0.371 0.0165 0.85 0.361 0.00468 0.28 0.798 0.8946 1908190 Bionet1_000588 FC(F)(F)c1cnc(N2CCN(CC2)c3ccc(C#N)cc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J11 compound treatment 0.376 0.0215 1.1 0.375 0.0187 1.13 1.5764 0.9999 1908191 Bionet1_000589 Clc1ccc(cc1)c2nc3ncccc3n2OCc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J12 compound treatment 0.408 0.0535 2.74 0.384 0.0277 1.67 3.1176 0.9719 1908192 Bionet1_000590 [O-][N+](=O)c1cccnc1N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J13 compound treatment 0.386 0.0315 1.61 0.374 0.0177 1.07 1.8953 0.9799 1908193 Bionet1_000591 Cc1ccc(cc1)c2nc3ncccc3n2OCc4cccc(c4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J14 compound treatment 0.373 0.0185 0.95 0.367 0.0107 0.64 1.1265 0.9823 1908194 Bionet1_000592 FC(F)(F)c1cnc(N2CCN(CC2)c3cccc(Cl)n3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J15 compound treatment 0.366 0.0115 0.59 0.368 0.0117 0.71 0.9161 0.9961 1908195 Bionet1_000593 Cc1ccc(cc1)c2nc3ncccc3n2OCc4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J16 compound treatment 0.395 0.0405 2.07 0.374 0.0177 1.07 2.2207 0.9523 1908196 Bionet1_000594 NC(=O)c1ccc(cc1)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J17 compound treatment 0.394 0.0395 2.02 0.362 0.00568 0.34 1.6723 0.8153 1908197 Bionet1_000595 Cc1ccc(cc1)c2nc3ncccc3n2OCc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J18 compound treatment 0.385 0.0305 1.56 0.36 0.00368 0.22 1.2615 0.7996 1908198 Bionet1_000596 CN(C)/C=N/NC(=O)CN1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J19 compound treatment 0.384 0.0295 1.51 0.371 0.0147 0.89 1.6949 0.9677 1687610 Bionet1_000597 COc1ccc(cc1)c2nc3ncccc3n2OCc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J20 compound treatment 0.373 0.0185 0.95 0.371 0.0147 0.89 1.2972 0.9994 1908199 Bionet1_000598 O/N=C/1\C(=O)N(Cc2ccc(Cl)c(Cl)c2)c3ccc(Cl)cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J21 compound treatment 0.372 0.0175 0.9 0.374 0.0177 1.07 1.3891 0.9963 1557171 Bionet1_000599 COc1ccc(cc1)c2nc3ncccc3n2OCc4ccc(Cl)cc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J22 compound treatment 0.394 0.0395 2.02 0.419 0.0627 3.78 4.1055 0.9569 1908200 Bionet1_000600 Cc1onc(c1C(=O)NC(=S)NC(=O)N)c2c(F)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J23 positive control 0.084 -0.27 -13.83 0.093 -0.263 -15.9 -21.0188 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 J24 positive control 0.088 -0.266 -13.62 0.094 -0.262 -15.84 -20.8315 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K01 mock treatment 0.349 -0.00545 -0.28 0.359 0.00268 0.16 -0.0828 -0.2568 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K02 mock treatment 0.353 -0.00145 -0.07 0.354 -0.00232 -0.14 -0.1516 -0.9558 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K03 compound treatment 0.351 -0.00345 -0.18 0.355 -0.00132 -0.08 -0.1812 -0.9356 1908201 Bionet1_000601 CCNC(=S)NNC(=O)c1ccc(=O)n(Cc2cccc(c2)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K04 compound treatment 0.373 0.0185 0.95 0.383 0.0267 1.61 1.8095 0.9681 1908202 Bionet1_000602 FC(F)(F)c1cccc(c1)C(=O)OCc2cn(nn2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K05 compound treatment 0.377 0.0225 1.15 0.394 0.0377 2.27 2.4236 0.9504 1908203 Bionet1_000603 CCn1c(S)nnc1c2ccc(=O)n(Cc3cccc(c3)C(F)(F)F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K06 compound treatment 0.367 0.0125 0.64 0.374 0.0177 1.07 1.2083 0.9704 1908204 Bionet1_000604 Clc1ccc(cc1Cl)n2cc(COC(=O)Nc3ccccc3)nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K07 compound treatment 0.347 -0.00745 -0.38 0.356 -3.21E-4 -0.02 -0.2831 -0.7422 1908205 Bionet1_000605 CNC(=S)NNC(=O)c1ccc(=O)n(Cc2ccc(Cl)cc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K08 compound treatment 0.383 0.0285 1.46 0.373 0.0167 1.01 1.7442 0.9836 1908206 Bionet1_000606 Cc1ccc(NC(=O)OCc2cn(nn2)c3ccc(Cl)c(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K09 compound treatment 0.387 0.0325 1.66 0.386 0.0297 1.79 2.4437 0.9993 1255396 Bionet1_000607 Cn1c(S)nnc1c2ccc(=O)n(Cc3ccc(Cl)cc3Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K10 compound treatment 0.385 0.0305 1.56 0.381 0.0247 1.49 2.158 0.9997 1908207 Bionet1_000608 Clc1cccc(NC(=O)OCc2cn(nn2)c3ccc(Cl)c(Cl)c3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K11 compound treatment 0.369 0.0145 0.74 0.37 0.0137 0.83 1.1099 0.9986 1672425 Bionet1_000609 Sc1nnc(c2ccc(=O)n(Cc3ccc(Cl)cc3Cl)c2)n1CC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K12 compound treatment 0.367 0.0125 0.64 0.359 0.00268 0.16 0.568 0.8585 1234090 Bionet1_000610 COc1ccc(cc1)C(=O)OCc2cn(nn2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K13 compound treatment 0.377 0.0225 1.15 0.354 -0.00232 -0.14 0.7162 0.6166 1908208 Bionet1_000611 CSc1nnc(c2cccn(Cc3ccc(Cl)c(Cl)c3)c2=O)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K14 compound treatment 0.372 0.0175 0.9 0.354 -0.00232 -0.14 0.5354 0.5895 1908209 Bionet1_000612 Clc1ccc(cc1Cl)n2cc(COC(=O)C(Cl)(Cl)Cl)nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K15 compound treatment 0.311 -0.0435 -2.22 0.311 -0.0453 -2.74 -3.5057 -0.9947 1024527 Bionet1_000613 COc1ccc(cc1)C(=O)C[n+]2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K16 compound treatment 0.384 0.0295 1.51 0.363 0.00668 0.4 1.3534 0.8655 1742367 Bionet1_000614 Cc1cccc(c1)C(=O)NCC(=O)N2CCN(CC2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K17 compound treatment 0.347 -0.00745 -0.38 0.351 -0.00532 -0.32 -0.4966 -0.9964 1908210 Bionet1_000615 [O-][N+](=O)c1cccc(c1)C(=O)C[n+]2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K18 compound treatment 0.384 0.0295 1.51 0.372 0.0157 0.95 1.7376 0.9746 1422775 Bionet1_000616 COc1ccc(cc1)C(=O)NCC(=O)N2CCN(CC2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K19 compound treatment 0.364 0.00955 0.49 0.364 0.00768 0.46 0.673 0.9997 1908211 Bionet1_000617 CCOC(=O)/C(=C\C(=C(\N)/N1CCN(CC1)c2ccc(OC)cc2)\C#N)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K20 compound treatment 0.358 0.00355 0.18 0.359 0.00268 0.16 0.2426 0.9983 1908212 Bionet1_000618 COC(=O)C(NC(=O)c1ccccc1)/C=N/OCc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K21 compound treatment 0.369 0.0145 0.74 0.369 0.0127 0.77 1.0672 0.9999 1708814 Bionet1_000619 CCOC(=O)c1cc(C#N)c([nH]c1=O)N2CCN(CC2)c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K22 compound treatment 0.395 0.0405 2.07 0.394 0.0377 2.27 3.0744 0.9989 1908213 Bionet1_000620 COC(=O)c1sc2ncccc2c1OCc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K23 positive control 0.087 -0.267 -13.68 0.093 -0.263 -15.9 -20.9104 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 K24 positive control 0.087 -0.267 -13.68 0.096 -0.26 -15.72 -20.7823 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L01 mock treatment 0.352 -0.00245 -0.13 0.32 -0.0363 -2.19 -1.6391 -0.7463 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L02 mock treatment 0.352 -0.00245 -0.13 0.356 -3.21E-4 -0.02 -0.1024 -0.807 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L03 compound treatment 0.326 -0.0285 -1.45 0.358 0.00168 0.1 -0.957 -0.6563 1908214 Bionet1_000621 Cc1ccc(COn2c(nc3ncccc23)c4ccc(Cl)cc4Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L04 compound treatment 0.349 -0.00545 -0.28 0.374 0.0177 1.07 0.5575 0.5055 1908215 Bionet1_000622 Cc1onc(c1C(=O)Nc2nc(=O)[nH]s2)c3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L05 compound treatment 0.341 -0.0135 -0.69 0.365 0.00868 0.52 -0.1159 -0.134 1908216 Bionet1_000623 COc1ccc(N/C(=N\C=[N+](C)C)/SC)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L06 compound treatment 0.241 -0.113 -5.8 0.232 -0.124 -7.51 -9.4089 -0.9919 1908217 Bionet1_000624 Cc1ccc2N(Cc3ccc(Cl)cc3)C(=O)/C(=N\OC(=O)CCCl)/c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L07 compound treatment 0.347 -0.00745 -0.38 0.352 -0.00432 -0.26 -0.4539 -0.9829 1908218 Bionet1_000625 CS/C(=N/C=[N+](C)C)/Nc1c(C)cccc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L08 compound treatment 0.358 0.00355 0.18 0.369 0.0127 0.77 0.6695 0.8511 1908219 Bionet1_000626 CCCCC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2)c3ccc(C)cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L09 compound treatment 0.376 0.0215 1.1 0.379 0.0227 1.37 1.7472 0.9942 1908220 Bionet1_000627 CN(C)/C=N/C(=O)c1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L10 compound treatment 0.348 -0.00645 -0.33 0.362 0.00568 0.34 0.0091 0.0192 1908221 Bionet1_000628 CC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2)c3ccc(Cl)cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L11 compound treatment 0.372 0.0175 0.9 0.373 0.0167 1.01 1.3464 0.9983 1908222 Bionet1_000629 Cc1ccc(NC(=O)c2cccn(Cc3cccc(c3)C(F)(F)F)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L12 compound treatment 0.355 5.48E-4 0.03 0.359 0.00268 0.16 0.1342 0.8175 1908223 Bionet1_000630 ClCC(=O)O/N=C/1\C(=O)N(Cc2ccc(Cl)cc2)c3ccc(Cl)cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L13 compound treatment 0.36 0.00555 0.28 0.374 0.0177 1.07 0.9553 0.865 1908224 Bionet1_000631 Cc1ccccc1NC(=O)c2cccn(Cc3cccc(c3)C(F)(F)F)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L14 compound treatment 0.359 0.00455 0.23 0.372 0.0157 0.95 0.8337 0.8554 1908225 Bionet1_000632 CC(=O)O/N=C/1\C(=O)N(Cc2cccc(c2)C(F)(F)F)c3ccc(Cl)cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L15 compound treatment 0.362 0.00755 0.39 0.387 0.0307 1.85 1.5825 0.8365 1908226 Bionet1_000633 Cc1ccc(NC(=O)c2cccn(Cc3cccc(c3)C(F)(F)F)c2=O)cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L16 compound treatment 0.358 0.00355 0.18 0.384 0.0277 1.67 1.3098 0.7793 1908227 Bionet1_000634 CN(C)/C=C(\C#N)/c1nn2c(cc(nc2c1C#N)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L17 compound treatment 0.378 0.0235 1.2 0.378 0.0217 1.31 1.7768 0.9991 1908228 Bionet1_000635 Cc1cccc(NC(=O)c2cccn(Cc3cccc(c3)C(F)(F)F)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L18 compound treatment 0.349 -0.00545 -0.28 0.359 0.00268 0.16 -0.0828 -0.2568 1908229 Bionet1_000636 Cc1cc(C)n2nc(/C(=C/c3ccc(Cl)cc3Cl)/C#N)c(C#N)c2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L19 compound treatment 0.401 0.0465 2.38 0.392 0.0357 2.15 3.206 0.9988 1908230 Bionet1_000637 Cc1ccc(NC(=O)c2cccn(Cc3cccc(c3)C(F)(F)F)c2=O)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L20 compound treatment 0.352 -0.00245 -0.13 0.362 0.00568 0.34 0.1538 0.4213 1908231 Bionet1_000638 FC(F)(F)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L21 compound treatment 0.363 0.00855 0.44 0.361 0.00468 0.28 0.5088 0.9777 1908232 Bionet1_000639 Clc1ccc2nc(c3ccccc3)n(OCc4ccccc4Cl)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L22 compound treatment 0.356 0.00155 0.08 0.362 0.00568 0.34 0.2984 0.8481 1908233 Bionet1_000640 FC(F)(F)c1ccccc1C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L23 positive control 0.087 -0.267 -13.68 0.093 -0.263 -15.9 -20.9104 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 L24 positive control 0.088 -0.266 -13.62 0.096 -0.26 -15.72 -20.7461 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M01 mock treatment 0.356 0.00155 0.08 0.329 -0.0273 -1.65 -1.1103 -0.6724 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M02 mock treatment 0.341 -0.0135 -0.69 0.356 -3.21E-4 -0.02 -0.5001 -0.7268 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M03 compound treatment 0.342 -0.0125 -0.64 0.362 0.00568 0.34 -0.2078 -0.2874 1908234 Bionet1_000641 ClCCCC(=O)Nc1cccn(Cc2c(Cl)cccc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M04 compound treatment 0.351 -0.00345 -0.18 0.345 -0.0113 -0.68 -0.6081 -0.8614 1908235 Bionet1_000642 COC(=O)c1sc2ncccc2c1OCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M05 compound treatment 0.354 -4.52E-4 -0.02 0.331 -0.0253 -1.53 -1.0972 -0.7177 1908236 Bionet1_000643 FC(F)(F)c1ccc(=O)n(Cc2ccc(cc2)C(=O)Nc3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M06 compound treatment 0.371 0.0165 0.85 0.373 0.0167 1.01 1.3103 0.9963 1908237 Bionet1_000644 COC(=O)c1sc2ncccc2c1OCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M07 compound treatment 0.353 -0.00145 -0.07 0.368 0.0117 0.71 0.446 0.6292 1908238 Bionet1_000645 FC(F)(F)c1ccc(=O)n(Cc2ccc(NC(=O)N3CCOCC3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M08 compound treatment 0.373 0.0185 0.95 0.377 0.0207 1.25 1.5533 0.9908 1908239 Bionet1_000646 COC(=O)c1sc2ncccc2c1OCc3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M09 compound treatment 0.351 -0.00345 -0.18 0.383 0.0267 1.61 1.014 0.6259 1908240 Bionet1_000647 CC(C)(C)NC(=O)Nc1ccc(Cn2cc(ccc2=O)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M10 compound treatment 0.362 0.00755 0.39 0.374 0.0177 1.07 1.0276 0.9054 1908241 Bionet1_000648 Cn1nc(c(C#N)c1S(=O)(=O)c2ccc(Cl)cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M11 compound treatment 0.352 -0.00245 -0.13 0.351 -0.00532 -0.32 -0.3158 -0.9158 1908242 Bionet1_000649 FC(F)(F)c1ccc(=O)n(Cc2ccc(NC(=O)Nc3ccccc3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M12 compound treatment 0.433 0.0785 4.02 0.448 0.0917 5.53 6.7535 0.9876 1908243 Bionet1_000650 CO/N=C/C1C(=O)N(OCc2ccc(Cl)cc2Cl)C(=O)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M13 compound treatment 0.486 0.132 6.73 0.491 0.135 8.13 10.5053 0.9956 1908244 Bionet1_000651 COC(=O)CSC(=O)Nc1ccc(Cn2cc(ccc2=O)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M14 compound treatment 0.354 -4.52E-4 -0.02 0.372 0.0157 0.95 0.6529 0.6896 1908245 Bionet1_000652 COC(=O)C(NC(=O)c1ccccc1)/C=N/OCc2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M15 compound treatment 0.363 0.00855 0.44 0.37 0.0137 0.83 0.893 0.9558 1908246 Bionet1_000653 Clc1ccc(Sc2ccc(Cc3ccc(Cl)cc3Cl)nn2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M16 compound treatment 0.374 0.0195 1.0 0.379 0.0227 1.37 1.6749 0.988 1908247 Bionet1_000654 COC(=O)C(NC(=O)c1ccccc1)/C=N/OCc2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M17 compound treatment 0.383 0.0285 1.46 0.373 0.0167 1.01 1.7442 0.9836 1908248 Bionet1_000655 Clc1cccc(Sc2ccc(Cc3ccc(Cl)cc3Cl)nn2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M18 compound treatment 0.357 0.00255 0.13 0.366 0.00968 0.58 0.5053 0.8441 1908249 Bionet1_000656 COC(=O)C(NC(=O)c1ccccc1)/C=N/OCc2ccc(cc2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M19 compound treatment 0.352 -0.00245 -0.13 0.376 0.0197 1.19 0.7514 0.629 1908250 Bionet1_000657 Clc1ccc(Cc2ccc(SCc3ccccc3)nn2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M20 compound treatment 0.351 -0.00345 -0.18 0.355 -0.00132 -0.08 -0.1812 -0.9356 1908251 Bionet1_000658 COC(=O)C(NC(=O)c1ccccc1)/C=N/OCc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M21 compound treatment 0.38 0.0255 1.31 0.389 0.0327 1.97 2.3187 0.98 1908252 Bionet1_000659 Fc1ccc(NC(=S)N/C=N\OCc2ccc(Cl)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M22 compound treatment 0.354 -4.52E-4 -0.02 0.366 0.00968 0.58 0.3968 0.6786 1908253 Bionet1_000660 COC(=O)c1ccccc1S(=O)(=O)c2c(C#N)c(nn2C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M23 positive control 0.09 -0.264 -13.52 0.09 -0.266 -16.08 -20.93 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 M24 positive control 0.091 -0.263 -13.47 0.098 -0.258 -15.59 -20.5523 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N01 mock treatment 0.36 0.00555 0.28 0.361 0.00468 0.28 0.4003 1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N02 mock treatment 0.353 -0.00145 -0.07 0.353 -0.00332 -0.2 -0.1943 -0.9086 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N03 compound treatment 0.333 -0.0215 -1.1 0.345 -0.0113 -0.68 -1.2589 -0.9741 1908254 Bionet1_000661 Clc1cccc(COn2c(nc3ccc(Cl)cc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N04 compound treatment 0.334 -0.0205 -1.05 0.359 0.00268 0.16 -0.6251 -0.5907 1908255 Bionet1_000662 ClC(Cl)(Cl)C(=O)c1cc(c[nH]1)C(=O)c2ccccc2Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N05 compound treatment 0.344 -0.0105 -0.53 0.364 0.00768 0.46 -0.0501 -0.0708 1908256 Bionet1_000663 Clc1ccc(COn2c(nc3ccc(Cl)cc23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N06 compound treatment 0.336 -0.0185 -0.94 0.35 -0.00632 -0.38 -0.937 -0.9207 1908257 Bionet1_000664 Fc1ccc(C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N07 compound treatment 0.371 0.0165 0.85 0.39 0.0337 2.03 2.036 0.9245 1908258 Bionet1_000665 CCOC(=O)COn1c(nc2ccc(Cl)cc12)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N08 compound treatment 0.343 -0.0115 -0.59 0.357 6.79E-4 0.04 -0.3851 -0.656 1908259 Bionet1_000666 Clc1ccsc1C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N09 compound treatment 0.336 -0.0185 -0.94 0.365 0.00868 0.52 -0.2967 -0.2749 1908260 Bionet1_000667 CCOC(=O)C(C)On1c(nc2ccc(Cl)cc12)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N10 compound treatment 0.364 0.00955 0.49 0.367 0.0107 0.64 0.8011 0.9906 1426038 Bionet1_000668 Clc1ccc(C(=O)c2c[nH]c(NC(=O)Nc3ccccc3)c2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N11 compound treatment 0.357 0.00255 0.13 0.368 0.0117 0.71 0.5907 0.8238 1908261 Bionet1_000669 COc1ccc(COn2c(nc3ccc(Cl)cc23)c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N12 compound treatment 0.379 0.0245 1.26 0.362 0.00568 0.34 1.13 0.8684 1908262 Bionet1_000670 Clc1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N13 compound treatment 0.372 0.0175 0.9 0.367 0.0107 0.64 1.0903 0.9868 1908263 Bionet1_000671 Cc1ccc(COn2c(nc3ccc(Cl)cc23)c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N14 compound treatment 0.378 0.0235 1.2 0.376 0.0197 1.19 1.6914 1.0 1908264 Bionet1_000672 Clc1ccc(C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N15 compound treatment 0.403 0.0485 2.48 0.381 0.0247 1.49 2.8088 0.9702 1566066 Bionet1_000673 CCOC(=O)COn1c(nc2ccc(Cl)cc12)c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N16 compound treatment 0.37 0.0155 0.8 0.374 0.0177 1.07 1.3168 0.9895 1908265 Bionet1_000674 Cc1onc(c1C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N17 compound treatment 0.349 -0.00545 -0.28 0.361 0.00468 0.28 0.0026 0.0066 1706192 Bionet1_000675 COc1ccc(Nc2nc3ccccc3c4nnc(c5ccccc5F)n24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N18 compound treatment 0.37 0.0155 0.8 0.353 -0.00332 -0.2 0.4204 0.5127 1908266 Bionet1_000676 Cn1cc(cc1C(=O)C(Cl)(Cl)Cl)C(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N19 compound treatment 0.351 -0.00345 -0.18 0.361 0.00468 0.28 0.0749 0.2249 1908267 Bionet1_000677 [O-][N+](=O)c1ccc2nc(c3ccc(Cl)cc3)n(OCc4ccccc4)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N20 compound treatment 0.411 0.0565 2.89 0.389 0.0327 1.97 3.4395 0.9826 1908268 Bionet1_000678 Clc1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NNc3cccc(Cl)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N21 compound treatment 0.36 0.00555 0.28 0.375 0.0187 1.13 0.9979 0.8583 1908269 Bionet1_000679 COc1ccc(cc1)c2nc3ccc(Cl)cc3n2OCc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N22 compound treatment 0.346 -0.00845 -0.43 0.355 -0.00132 -0.08 -0.362 -0.8237 1908270 Bionet1_000680 Clc1ccccc1C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N23 positive control 0.086 -0.268 -13.73 0.092 -0.264 -15.96 -20.9892 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 N24 positive control 0.088 -0.266 -13.62 0.097 -0.259 -15.65 -20.7035 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O01 mock treatment 0.356 0.00155 0.08 0.361 0.00468 0.28 0.2557 0.8717 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O02 mock treatment 0.359 0.00455 0.23 0.359 0.00268 0.16 0.2788 0.9842 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O03 compound treatment 0.339 -0.0155 -0.79 0.362 0.00568 0.34 -0.3163 -0.3672 1908271 Bionet1_000681 Cc1nn(c(N)c1c2cccc(c2)C(F)(F)F)c3cccc(c3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O04 compound treatment 0.349 -0.00545 -0.28 0.376 0.0197 1.19 0.6429 0.5269 1908272 Bionet1_000682 Cn1nc(c(C#N)c1S(=O)(=O)Cc2cccc(c2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O05 compound treatment 0.362 0.00755 0.39 0.369 0.0127 0.77 0.8141 0.9498 1908273 Bionet1_000683 FC(F)(F)c1cccc(N/C=C\2/C=NN(C2=O)c3cccc(Cl)n3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O06 compound treatment 0.338 -0.0165 -0.84 0.356 -3.21E-4 -0.02 -0.6085 -0.7232 1908274 Bionet1_000684 Cn1nc(c(C#N)c1S(=O)(=O)Cc2ccc(cc2)C(C)(C)C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O07 compound treatment 0.367 0.0125 0.64 0.37 0.0137 0.83 1.0376 0.9922 1908275 Bionet1_000685 Clc1ccc(CON/C=C\2/C=NN(C2=O)c3cccc(Cl)n3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O08 compound treatment 0.373 0.0185 0.95 0.379 0.0227 1.37 1.6387 0.9839 1908276 Bionet1_000686 Cn1nc(c(C#N)c1S(=O)(=O)c2cccc(c2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O09 compound treatment 0.345 -0.00945 -0.48 0.366 0.00968 0.58 0.0714 0.0942 1168349 Bionet1_000687 Clc1cccc(Cl)c1Cn2n(c3ccccc3)c4ncccc4c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O10 compound treatment 0.365 0.0105 0.54 0.365 0.00868 0.52 0.7518 0.9999 1493607 Bionet1_000688 Clc1ccc(cc1)N2CCN(CC2)c3ncnc4c5ccccc5[nH]c34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O11 compound treatment 0.361 0.00655 0.33 0.358 0.00168 0.1 0.3084 0.8816 1908277 Bionet1_000689 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O12 compound treatment 0.375 0.0205 1.05 0.388 0.0317 1.91 2.0952 0.9602 1677052 Bionet1_000690 COc1ccc(cc1)N2CCN(CC2)c3ncnc4c5ccccc5[nH]c34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O13 compound treatment 0.382 0.0275 1.41 0.39 0.0337 2.03 2.4337 0.9839 1908278 Bionet1_000691 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2ccc(cc2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O14 compound treatment 0.339 -0.0155 -0.79 0.369 0.0127 0.77 -0.0175 -0.0159 1908279 Bionet1_000692 Cc1ccc(cc1)S(=O)(=O)NC(=O)OCc2cn(nn2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O15 compound treatment 0.358 0.00355 0.18 0.371 0.0147 0.89 0.7549 0.8346 1908280 Bionet1_000693 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2ccc(F)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O16 compound treatment 0.369 0.0145 0.74 0.371 0.0147 0.89 1.1526 0.9962 1323356 Bionet1_000694 Nc1nn(cc1c2ccc(Cl)cc2)c3ncnc4c5ccccc5[nH]c34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O17 compound treatment 0.367 0.0125 0.64 0.382 0.0257 1.55 1.5498 0.9238 1908281 Bionet1_000695 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O18 compound treatment 0.353 -0.00145 -0.07 0.366 0.00968 0.58 0.3607 0.6124 1908282 Bionet1_000696 Clc1ccc(/C=N/Nc2ncnc3c4ccccc4[nH]c23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O19 compound treatment 0.369 0.0145 0.74 0.368 0.0117 0.71 1.0245 0.9996 1908283 Bionet1_000697 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2cccc(Cl)c2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O20 compound treatment 0.35 -0.00445 -0.23 0.362 0.00568 0.34 0.0814 0.1979 1908284 Bionet1_000698 Clc1cccc(Cl)c1COn2c(nc3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O21 compound treatment 0.35 -0.00445 -0.23 0.362 0.00568 0.34 0.0814 0.1979 1908285 Bionet1_000699 CN(C)S(=O)(=O)Oc1ccc(cc1)C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O22 compound treatment 0.346 -0.00845 -0.43 0.372 0.0157 0.95 0.3637 0.3495 1908286 Bionet1_000700 Clc1ccc(COn2c(nc3ccccc23)c4ccccc4)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O23 positive control 0.084 -0.27 -13.83 0.091 -0.265 -16.02 -21.1042 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 O24 positive control 0.087 -0.267 -13.68 0.098 -0.258 -15.59 -20.6969 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P01 mock treatment 0.358 0.00355 0.18 0.366 0.00968 0.58 0.5414 0.885 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P02 mock treatment 0.365 0.0105 0.54 0.365 0.00868 0.52 0.7518 0.9999 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P03 compound treatment 0.346 -0.00845 -0.43 0.374 0.0177 1.07 0.4491 0.39 1908287 Bionet1_000701 COc1ccc(cc1)c2nc3ccc(Cl)cc3n2OCc4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P04 compound treatment 0.338 -0.0165 -0.84 0.35 -0.00632 -0.38 -0.8647 -0.9361 1908288 Bionet1_000702 Fc1ccc(C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P05 compound treatment 0.344 -0.0105 -0.53 0.364 0.00768 0.46 -0.0501 -0.0708 1908289 Bionet1_000703 COc1ccc(cc1)c2nc3ccc(Cl)cc3n2OCc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P06 compound treatment 0.352 -0.00245 -0.13 0.35 -0.00632 -0.38 -0.3585 -0.8925 1908290 Bionet1_000704 Fc1cccc(F)c1C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P07 compound treatment 0.354 -4.52E-4 -0.02 0.373 0.0167 1.01 0.6956 0.6907 1908291 Bionet1_000705 COc1ccc(cc1)c2nc3ccc(Cl)cc3n2OCc4ccc(C)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P08 compound treatment 0.351 -0.00345 -0.18 0.36 0.00368 0.22 0.0322 0.1136 1908292 Bionet1_000706 Clc1cccc(Cl)c1C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P09 compound treatment 0.34 -0.0145 -0.74 0.359 0.00268 0.16 -0.4082 -0.5396 1908293 Bionet1_000707 COc1ccc(cc1)c2nc3ccc(Cl)cc3n2OCc4cc(C)cc(C)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P10 compound treatment 0.333 -0.0215 -1.1 0.349 -0.00732 -0.44 -1.0881 -0.9201 1908294 Bionet1_000708 Cn1cc(cc1C(=O)C(Cl)(Cl)Cl)C(=O)c2cccc(Cl)c2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P11 compound treatment 0.351 -0.00345 -0.18 0.352 -0.00432 -0.26 -0.3093 -0.9819 1908295 Bionet1_000709 CCOC(=O)COn1c(nc2ccc(cc12)[N+](=O)[O-])c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P12 compound treatment 0.378 0.0235 1.2 0.384 0.0277 1.67 2.0329 0.9871 1908296 Bionet1_000710 Clc1cccc(C(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P13 compound treatment 0.333 -0.0215 -1.1 0.365 0.00868 0.52 -0.4051 -0.3333 1908297 Bionet1_000711 Cc1ccc(COn2c(nc3ccc(cc23)[N+](=O)[O-])c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P14 compound treatment 0.367 0.0125 0.64 0.357 6.79E-4 0.04 0.4827 0.7507 1908298 Bionet1_000712 CN(C)CCCNC(=O)c1cc(c[nH]1)C(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P15 compound treatment 0.354 -4.52E-4 -0.02 0.368 0.0117 0.71 0.4822 0.6836 1908299 Bionet1_000713 COc1ccc(COn2c(nc3ccc(Cl)cc23)c4ccc(OC)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P16 compound treatment 0.366 0.0115 0.59 0.364 0.00768 0.46 0.7453 0.9928 1375498 Bionet1_000714 CCOC(=O)c1ccccc1c2csc(Nc3ccc(Cl)c(Cl)c3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P17 compound treatment 0.327 -0.0275 -1.4 0.365 0.00868 0.52 -0.6221 -0.4152 1908300 Bionet1_000715 CCOC(=O)C(C)On1c(nc2ccc(cc12)[N+](=O)[O-])c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P18 compound treatment 0.38 0.0255 1.31 0.363 0.00668 0.4 1.2088 0.8842 1908301 Bionet1_000716 CCOC(=O)c1ccccc1c2csc(NC(=O)c3ccc(F)cc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P19 compound treatment 0.345 -0.00945 -0.48 0.365 0.00868 0.52 0.0287 0.0403 1908302 Bionet1_000717 [O-][N+](=O)c1ccc2nc(c3ccccc3)n(OCc4ccc(Cl)cc4)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P20 compound treatment 0.35 -0.00445 -0.23 0.368 0.0117 0.71 0.3376 0.4557 1908303 Bionet1_000718 FC(F)(F)Oc1ccc(NC(=O)c2csc(n2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P21 compound treatment 0.365 0.0105 0.54 0.378 0.0217 1.31 1.3068 0.9232 1599721 Bionet1_000719 COc1ccc(Oc2nc3ccccc3c4nnc(c5ccccc5F)n24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P22 compound treatment 0.36 0.00555 0.28 0.361 0.00468 0.28 0.4003 1.0 1908304 Bionet1_000720 Cc1nc(sc1C(=O)Nc2cccc(c2)C(F)(F)F)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P23 positive control 0.089 -0.265 -13.57 0.094 -0.262 -15.84 -20.7954 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.569 P24 positive control 0.089 -0.265 -13.57 0.109 -0.247 -14.93 -20.1551 -0.9989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A01 mock treatment 0.325 -0.0307 -1.57 0.327 -0.0286 -1.73 -2.3284 -0.9989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A02 mock treatment 0.326 -0.0297 -1.52 0.325 -0.0306 -1.85 -2.3776 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A03 compound treatment 0.322 -0.0337 -1.72 0.326 -0.0296 -1.79 -2.4796 -0.9998 1442469 Bionet1_000721 Cc1nc(sc1C(=O)Nc2ccc(Cl)c(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A04 compound treatment 0.326 -0.0297 -1.52 0.324 -0.0316 -1.91 -2.4203 -0.9936 1675922 Bionet1_000722 Cc1ccc(cc1)S(=O)(=O)CCCS(=O)(=O)c2ccc(C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A05 compound treatment 0.318 -0.0377 -1.93 0.321 -0.0346 -2.09 -2.8376 -0.9992 1908305 Bionet1_000723 Cc1nc(sc1C(=O)Nc2ccc(OC(F)(F)F)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A06 compound treatment 0.321 -0.0347 -1.77 0.328 -0.0276 -1.66 -2.4304 -0.9995 1908306 Bionet1_000724 CCNc1nc(Oc2c(Cl)cccc2Cl)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A07 compound treatment 0.341 -0.0147 -0.75 0.34 -0.0156 -0.94 -1.195 -0.9937 1908307 Bionet1_000725 FC(F)(F)c1cnc(NC(=S)NC(=O)c2ccccc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A08 compound treatment 0.326 -0.0297 -1.52 0.32 -0.0356 -2.15 -2.5911 -0.9855 1908308 Bionet1_000726 CCNc1nc(Sc2ccc(Cl)cc2Cl)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A09 compound treatment 0.318 -0.0377 -1.93 0.323 -0.0326 -1.97 -2.7523 -0.9999 1908309 Bionet1_000727 [O-][N+](=O)c1cc(ccc1n2cncn2)C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A10 compound treatment 0.316 -0.0397 -2.03 0.315 -0.0406 -2.45 -3.1661 -0.9956 1908310 Bionet1_000728 CCNc1nc(SCc2ccc(Cl)c(Cl)c2)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A11 compound treatment 0.323 -0.0327 -1.67 0.328 -0.0276 -1.66 -2.3581 -1.0 1908311 Bionet1_000729 COc1ccc(NC(=O)c2ccc(c(c2)[N+](=O)[O-])n3cncn3)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A12 compound treatment 0.319 -0.0367 -1.87 0.332 -0.0236 -1.42 -2.3319 -0.9908 1908312 Bionet1_000730 CCNc1nc(Sc2ccc(Cl)c(Cl)c2)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A13 compound treatment 0.33 -0.0257 -1.31 0.327 -0.0286 -1.73 -2.1476 -0.9909 1908313 Bionet1_000731 Cc1c(Cl)cccc1NC(=O)c2ccc(c(c2)[N+](=O)[O-])n3cccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A14 compound treatment 0.325 -0.0307 -1.57 0.321 -0.0346 -2.09 -2.5845 -0.99 1908314 Bionet1_000732 CCNc1nc(Oc2cc(Cl)cc(Cl)c2)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A15 compound treatment 0.326 -0.0297 -1.52 0.324 -0.0316 -1.91 -2.4203 -0.9936 1908315 Bionet1_000733 FC(F)(F)c1cnc(Nc2nc(cs2)c3ccc(Cl)cc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A16 compound treatment 0.324 -0.0317 -1.62 0.322 -0.0336 -2.03 -2.578 -0.9938 1908316 Bionet1_000734 CCNc1nc(Oc2ccc(Cl)cc2Cl)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A17 compound treatment 0.328 -0.0277 -1.41 0.33 -0.0256 -1.54 -2.0919 -0.999 1600344 Bionet1_000735 CCOC(=O)c1ccccc1c2csc(NC(=O)c3ccc(OC)cc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A18 compound treatment 0.325 -0.0307 -1.57 0.322 -0.0336 -2.03 -2.5419 -0.9919 1129864 Bionet1_000736 CC(C)(C)c1ccc(CS(=O)(=O)CCCS(=O)(=O)c2ccccc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A19 compound treatment 0.334 -0.0217 -1.11 0.329 -0.0266 -1.6 -1.9176 -0.9836 1908317 Bionet1_000737 CN(C)/C=N/C(=O)N1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A20 compound treatment 0.321 -0.0347 -1.77 0.323 -0.0326 -1.97 -2.6438 -0.9986 1908318 Bionet1_000738 CCNc1nc(SCc2ccc(cc2)C(C)(C)C)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A21 compound treatment 0.322 -0.0337 -1.72 0.321 -0.0346 -2.09 -2.693 -0.9954 1548652 Bionet1_000739 Fc1ccc(NC(=O)c2csc(n2)c3ccc(Cl)cc3)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A22 compound treatment 0.329 -0.0267 -1.36 0.322 -0.0336 -2.03 -2.3972 -0.9813 1908319 Bionet1_000740 FC(F)(F)c1cnc(N2CCN(CC2)C(=O)CN3CCOCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A23 positive control 0.087 -0.269 -13.74 0.086 -0.27 -16.27 -21.2211 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 A24 positive control 0.09 -0.266 -13.58 0.098 -0.258 -15.55 -20.6004 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B01 mock treatment 0.352 -0.00366 -0.19 0.352 -0.00358 -0.22 -0.285 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B02 mock treatment 0.366 0.0103 0.53 0.369 0.0134 0.81 0.9468 0.9787 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B03 compound treatment 0.371 0.0153 0.78 0.396 0.0404 2.44 2.2801 0.8896 1908320 Bionet1_000741 O=C(CCSSCCC(=O)Nc1ccccc1)Nc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B04 compound treatment 0.368 0.0123 0.63 0.365 0.00942 0.57 0.8484 0.9986 1908321 Bionet1_000742 Cc1cc(C)n(n1)c2nnc(nn2)N3CCN(CC3)c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B05 compound treatment 0.364 0.00834 0.43 0.358 0.00242 0.15 0.405 0.898 1908322 Bionet1_000743 Cc1cc(C)cc(OC(F)(F)C(=O)Nc2cc(Cl)cc(Cl)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B06 compound treatment 0.36 0.00434 0.22 0.358 0.00242 0.15 0.2603 0.9793 1603190 Bionet1_000744 O=S(=O)(C1CON(Cc2ccccc2)C1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B07 compound treatment 0.357 0.00134 0.07 0.353 -0.00258 -0.16 -0.0616 -0.3616 1908323 Bionet1_000745 Cc1cc(C)cc(OC(F)(F)C(=O)Nc2ccc(OC(F)(F)F)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B08 compound treatment 0.367 0.0113 0.58 0.364 0.00842 0.51 0.7695 0.9978 1330374 Bionet1_000746 O=C(CON1C(=O)c2ccccc2C1=O)N3CCN(CC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B09 compound treatment 0.368 0.0123 0.63 0.365 0.00942 0.57 0.8484 0.9986 1908324 Bionet1_000747 COc1ccc(OC(F)(F)C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B10 compound treatment 0.362 0.00634 0.32 0.358 0.00242 0.15 0.3326 0.9351 1908325 Bionet1_000748 CC(=O)c1ccc(cc1)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B11 compound treatment 0.355 -6.56E-4 -0.03 0.351 -0.00458 -0.28 -0.2193 -0.7871 1908326 Bionet1_000749 COC(=O)c1ccccc1NC(=O)C(F)(F)Oc2ccc(OC)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B12 compound treatment 0.361 0.00534 0.27 0.357 0.00142 0.09 0.2538 0.8863 1908327 Bionet1_000750 C/C(=N\O)/c1ccc(cc1)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B13 compound treatment 0.372 0.0163 0.84 0.372 0.0164 0.99 1.2918 0.9964 1908328 Bionet1_000751 COc1ccc(OC(F)(F)C(=O)Nc2c(Cl)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B14 compound treatment 0.365 0.00934 0.48 0.363 0.00742 0.45 0.6545 0.9995 1908329 Bionet1_000752 Cn1cc(cc1/C=C(\C#N)/c2ccccn2)C(=O)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B15 compound treatment 0.357 0.00134 0.07 0.355 -5.81E-4 -0.04 0.0238 0.3085 1908330 Bionet1_000753 COC(=O)c1ccccc1NC(=O)C(F)(F)Oc2ccc(cc2)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B16 compound treatment 0.347 -0.00866 -0.44 0.354 -0.00158 -0.1 -0.3804 -0.8402 1908331 Bionet1_000754 FC(F)(F)c1cc(c2ccc(Sc3nc[nH]n3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B17 compound treatment 0.364 0.00834 0.43 0.364 0.00842 0.51 0.6611 0.9962 1908332 Bionet1_000755 CC(C)(C)c1ccc(OC(F)(F)C(=O)Nc2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B18 compound treatment 0.364 0.00834 0.43 0.368 0.0124 0.75 0.8318 0.9643 1702138 Bionet1_000756 COc1ccc(cc1OC)c2cn(nc2C)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B19 compound treatment 0.359 0.00334 0.17 0.36 0.00442 0.27 0.3095 0.9769 1908333 Bionet1_000757 CON/C=N/C(=O)C1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B20 compound treatment 0.365 0.00934 0.48 0.363 0.00742 0.45 0.6545 0.9995 1908334 Bionet1_000758 CO/N=C/C(C)C(=O)c1ccc2c(Br)c(OC)ccc2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B21 compound treatment 0.366 0.0103 0.53 0.369 0.0134 0.81 0.9468 0.9787 1908335 Bionet1_000759 CC(C)(C)c1ccc(OC(F)(F)C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B22 compound treatment 0.366 0.0103 0.53 0.364 0.00842 0.51 0.7334 0.9998 1908336 Bionet1_000760 COc1ccc(cc1OC)c2nnn3c2nc(N)c4ncc(cc43)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B23 positive control 0.09 -0.266 -13.58 0.089 -0.267 -16.09 -20.9846 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 B24 positive control 0.089 -0.267 -13.63 0.09 -0.266 -16.03 -20.978 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C01 mock treatment 0.353 -0.00266 -0.14 0.352 -0.00358 -0.22 -0.2489 -0.9749 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C02 mock treatment 0.362 0.00634 0.32 0.361 0.00542 0.33 0.4607 1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C03 compound treatment 0.355 -6.56E-4 -0.03 0.353 -0.00258 -0.16 -0.1339 -0.8401 1908337 Bionet1_000761 FC(F)(F)Oc1ccc(NC(=O)c2csc(n2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C04 compound treatment 0.365 0.00934 0.48 0.359 0.00342 0.21 0.4838 0.9296 1908338 Bionet1_000762 FC(F)(F)c1cnc(N2CCN(CC2)c3nc(CCl)cs3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C05 compound treatment 0.365 0.00934 0.48 0.358 0.00242 0.15 0.4411 0.8829 1908339 Bionet1_000763 Fc1ccc(NC(=O)c2csc(n2)c3cccc(c3)C(F)(F)F)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C06 compound treatment 0.361 0.00534 0.27 0.358 0.00242 0.15 0.2965 0.9569 1440891 Bionet1_000764 Nc1c(C#N)c(COc2ccc(Cl)cc2Cl)nc(=O)n1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C07 compound treatment 0.357 0.00134 0.07 0.348 -0.00758 -0.46 -0.275 -0.5943 1908340 Bionet1_000765 FC(F)(F)c1cccc(c1)c2nc(cs2)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C08 compound treatment 0.36 0.00434 0.22 0.358 0.00242 0.15 0.2603 0.9793 1908341 Bionet1_000766 Clc1ccc(Nc2nc(Cn3cncn3)nn2c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C09 compound treatment 0.354 -0.00166 -0.08 0.349 -0.00658 -0.4 -0.3408 -0.839 1908342 Bionet1_000767 COC(=O)c1ccc(cc1)c2nc(cs2)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C10 compound treatment 0.356 3.44E-4 0.02 0.353 -0.00258 -0.16 -0.0977 -0.6234 1908343 Bionet1_000768 Fc1ccc(Sc2ccc(NC(=O)c3cccc(c3)C(F)(F)F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C11 compound treatment 0.355 -6.56E-4 -0.03 0.355 -5.81E-4 -0.04 -0.0485 -0.9998 1908344 Bionet1_000769 Cc1nc(sc1C(=O)Nc2ccc(F)cc2F)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C12 compound treatment 0.351 -0.00466 -0.24 0.35 -0.00558 -0.34 -0.4066 -0.9856 1908345 Bionet1_000770 CCOC(=O)CSc1ccc(cn1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C13 compound treatment 0.356 3.44E-4 0.02 0.349 -0.00658 -0.4 -0.2685 -0.6752 1538007 Bionet1_000771 O=C(Nc1ccccc1)c2ccc(cc2)c3nc(cs3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C14 compound treatment 0.348 -0.00766 -0.39 0.348 -0.00758 -0.46 -0.6004 -0.997 1908346 Bionet1_000772 CCOC(=O)CSc1ccc(cn1)C(=O)Nc2ccc(F)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C15 compound treatment 0.35 -0.00566 -0.29 0.347 -0.00858 -0.52 -0.5708 -0.9621 1190182 Bionet1_000773 Fc1ccc(NC(=O)c2ccc(cc2)c3nc(cs3)c4ccccc4)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C16 compound treatment 0.363 0.00734 0.38 0.358 0.00242 0.15 0.3688 0.9153 1132001 Bionet1_000774 CCC(C)S(=O)(=O)c1ccc(cn1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C17 compound treatment 0.382 0.0263 1.35 0.382 0.0264 1.59 2.0802 0.9965 1908347 Bionet1_000775 CN(C)C(=O)c1ccc(cc1)c2nc(cs2)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C18 compound treatment 0.358 0.00234 0.12 0.353 -0.00258 -0.16 -0.0254 -0.1293 1134836 Bionet1_000776 Cc1ccc(Sc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C19 compound treatment 0.354 -0.00166 -0.08 0.352 -0.00358 -0.22 -0.2127 -0.9163 1367743 Bionet1_000777 Clc1ccc(c2csc(n2)c3ccc(cc3)C(=O)NCC=C)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C20 compound treatment 0.363 0.00734 0.38 0.357 0.00142 0.09 0.3261 0.8467 1439191 Bionet1_000778 CCCCS(=O)(=O)c1ccc(cn1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C21 compound treatment 0.352 -0.00366 -0.19 0.354 -0.00158 -0.1 -0.1997 -0.9513 1599031 Bionet1_000779 Fc1ccc(NC(=O)c2ccc(cc2)c3nc(cs3)c4ccc(F)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C22 compound treatment 0.361 0.00534 0.27 0.362 0.00642 0.39 0.4672 0.9854 1908348 Bionet1_000780 Cc1ccc(Sc2ccc(NC(=O)c3cccc(c3)C(F)(F)F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C23 positive control 0.086 -0.27 -13.79 0.085 -0.271 -16.33 -21.2999 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 C24 positive control 0.094 -0.262 -13.38 0.093 -0.263 -15.85 -20.6692 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D01 mock treatment 0.349 -0.00666 -0.34 0.346 -0.00958 -0.58 -0.6496 -0.968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D02 mock treatment 0.35 -0.00566 -0.29 0.349 -0.00658 -0.4 -0.4854 -0.9878 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D03 compound treatment 0.346 -0.00966 -0.49 0.348 -0.00758 -0.46 -0.6727 -0.9993 1908349 Bionet1_000781 FC(F)(F)c1cnc(N2CCN(CC2)c3c[nH]c(=O)[nH]c3=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D04 compound treatment 0.35 -0.00566 -0.29 0.349 -0.00658 -0.4 -0.4854 -0.9878 1908350 Bionet1_000782 Nc1nc2c(nnn2c3cc(cnc13)C(F)(F)F)c4ccc(Cl)cc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D05 compound treatment 0.349 -0.00666 -0.34 0.346 -0.00958 -0.58 -0.6496 -0.968 1908351 Bionet1_000783 CSc1sn(C(=O)NS(=O)(=O)c2ccc(C)cc2)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D06 compound treatment 0.346 -0.00966 -0.49 0.348 -0.00758 -0.46 -0.6727 -0.9993 1908352 Bionet1_000784 Nc1nc2c(nnn2c3cc(cnc13)C(F)(F)F)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D07 compound treatment 0.337 -0.0187 -0.95 0.348 -0.00758 -0.46 -0.9981 -0.9434 1908353 Bionet1_000785 Cc1onc(c1C(=O)NOCCOc2ccccc2)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D08 compound treatment 0.345 -0.0107 -0.54 0.349 -0.00658 -0.4 -0.6662 -0.9879 1908354 Bionet1_000786 Nc1nc2c(nnn2c3cc(cnc13)C(F)(F)F)c4c(F)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D09 compound treatment 0.346 -0.00966 -0.49 0.344 -0.0116 -0.7 -0.8435 -0.9855 1908355 Bionet1_000787 FC(F)(F)c1cccc(OCCON2C(=O)c3ccccc3C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D10 compound treatment 0.366 0.0103 0.53 0.361 0.00542 0.33 0.6053 0.9733 1908356 Bionet1_000788 CCOC(=O)c1sc(=S)sc1SCc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D11 compound treatment 0.358 0.00234 0.12 0.353 -0.00258 -0.16 -0.0254 -0.1293 1214859 Bionet1_000789 Cc1ccc(NC(=O)N2CCOC32CCN(CC3)c4ncccn4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D12 compound treatment 0.353 -0.00266 -0.14 0.35 -0.00558 -0.34 -0.3343 -0.9202 1908357 Bionet1_000790 CCOC(=O)c1sc(=S)sc1SCc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D13 compound treatment 0.425 0.0693 3.55 0.416 0.0604 3.65 5.0863 0.9999 1908358 Bionet1_000791 COc1ccc(cc1)C(=O)N2CCOC32CCN(CC3)c4ccc(cc4)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D14 compound treatment 0.343 -0.0127 -0.65 0.346 -0.00958 -0.58 -0.8666 -0.9984 1130635 Bionet1_000792 CCOC(=O)c1sc(=S)sc1SCc2cccc(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D15 compound treatment 0.342 -0.0137 -0.7 0.342 -0.0136 -0.82 -1.0735 -0.9968 1723867 Bionet1_000793 Clc1ccc(C(=O)N2CCOC32CCN(CC3)c4ncccn4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D16 compound treatment 0.335 -0.0207 -1.06 0.334 -0.0216 -1.3 -1.6681 -0.9946 1355653 Bionet1_000794 Clc1ccc(COc2ccsc2NC(=O)Nc3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D17 compound treatment 0.356 3.44E-4 0.02 0.352 -0.00358 -0.22 -0.1404 -0.6475 1253955 Bionet1_000795 COc1ccc(cc1)C(=O)N2CCOC32CCN(CC3)c4ncccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D18 compound treatment 0.348 -0.00766 -0.39 0.348 -0.00758 -0.46 -0.6004 -0.997 1908359 Bionet1_000796 CN(C)c1nnc(o1)/C(=C/c2cc(cn2C)C(=O)c3cccc(Cl)c3)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D19 compound treatment 0.35 -0.00566 -0.29 0.346 -0.00958 -0.58 -0.6135 -0.9487 1908360 Bionet1_000797 COc1ccc(N/C=C(\C#N)/C(=O)N/C=N/OCc2ccc(cc2)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D20 compound treatment 0.448 0.0923 4.72 0.452 0.0964 5.82 7.4546 0.9946 1908361 Bionet1_000798 Cn1cc(cc1/C=C(\C#N)/C(=O)c2ccccc2)C(=O)c3c(F)cccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D21 compound treatment 0.351 -0.00466 -0.24 0.352 -0.00358 -0.22 -0.3212 -0.9988 1908362 Bionet1_000799 FC(F)(F)c1cccc(c1)N2CCN(CC2)c3cnc4ccccc4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D22 compound treatment 0.357 0.00134 0.07 0.36 0.00442 0.27 0.2372 0.8611 1908363 Bionet1_000800 COC(=O)c1c(N)sc2CN(CCc12)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D23 positive control 0.086 -0.27 -13.79 0.089 -0.267 -16.09 -21.1292 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 D24 positive control 0.092 -0.264 -13.48 0.092 -0.264 -15.91 -20.7842 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E01 mock treatment 0.352 -0.00366 -0.19 0.351 -0.00458 -0.28 -0.3277 -0.9818 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E02 mock treatment 0.36 0.00434 0.22 0.357 0.00142 0.09 0.2176 0.9142 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E03 compound treatment 0.36 0.00434 0.22 0.358 0.00242 0.15 0.2603 0.9793 1908364 Bionet1_000801 N/C(=N\NC(=O)c1ccc(Cl)cc1)/CSc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E04 compound treatment 0.356 3.44E-4 0.02 0.359 0.00342 0.21 0.1584 0.7646 1669123 Bionet1_000802 Cc1ccc(cc1)S(=O)(=O)c2ccc(NC(=O)c3ccc(Cl)cc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E05 compound treatment 0.355 -6.56E-4 -0.03 0.358 0.00242 0.15 0.0795 0.5308 1908365 Bionet1_000803 N/C(=N\NC(=O)c1ccc(Cl)cc1)/COc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E06 compound treatment 0.36 0.00434 0.22 0.358 0.00242 0.15 0.2603 0.9793 1146305 Bionet1_000804 Cc1ccc(Sc2ccc(NC(=O)c3c(F)cccc3F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E07 compound treatment 0.339 -0.0167 -0.85 0.353 -0.00258 -0.16 -0.7124 -0.8228 1908366 Bionet1_000805 Cc1c(Cl)cccc1NC(=O)c2ccc(c(c2)[N+](=O)[O-])n3cncn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E08 compound treatment 0.376 0.0203 1.04 0.371 0.0154 0.93 1.3938 0.9985 1528774 Bionet1_000806 Fc1ccc(Sc2ccc(NC(=O)c3ccc(Cl)cc3Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E09 compound treatment 0.353 -0.00266 -0.14 0.355 -5.81E-4 -0.04 -0.1208 -0.8614 1908367 Bionet1_000807 COc1ccc(NC(=O)c2ccc(c(c2)[N+](=O)[O-])n3cncn3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E10 compound treatment 0.351 -0.00466 -0.24 0.355 -5.81E-4 -0.04 -0.1931 -0.8026 1482424 Bionet1_000808 Clc1ccc(cc1Cl)c2ccnc3nc(nn23)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E11 compound treatment 0.362 0.00634 0.32 0.371 0.0154 0.93 0.8876 0.9004 1908368 Bionet1_000809 COc1ccc(NC(=O)c2ccc(c(c2)[N+](=O)[O-])n3cccn3)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E12 compound treatment 0.361 0.00534 0.27 0.365 0.00942 0.57 0.5953 0.9436 1433181 Bionet1_000810 CC(Oc1ccc(Cl)cc1Cl)c2ccnc3nc(nn23)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E13 compound treatment 0.352 -0.00366 -0.19 0.358 0.00242 0.15 -0.0289 -0.1219 1908369 Bionet1_000811 COc1ccc(NC(=O)c2ccc(c(c2)[N+](=O)[O-])n3cccn3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E14 compound treatment 0.364 0.00834 0.43 0.367 0.0114 0.69 0.7891 0.9734 1681221 Bionet1_000812 C1CN(CCN1c2nc3nccc(c4ccccc4)n3n2)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E15 compound treatment 0.355 -6.56E-4 -0.03 0.356 4.19E-4 0.03 -0.0058 -0.1386 1908370 Bionet1_000813 CCOC(=O)c1c(NC(=O)Nc2ccc(Cl)cc2)[nH]cc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E16 compound treatment 0.352 -0.00366 -0.19 0.357 0.00142 0.09 -0.0716 -0.3482 1733643 Bionet1_000814 COc1ccc(cc1)c2ccnc3nc(nn23)N4CCN(CC4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E17 compound treatment 0.36 0.00434 0.22 0.365 0.00942 0.57 0.5591 0.9159 1369019 Bionet1_000815 Brc1ccc(NC(=O)c2csc(n2)c3ccncc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E18 compound treatment 0.358 0.00234 0.12 0.361 0.00542 0.33 0.3161 0.9072 1681135 Bionet1_000816 Fc1ccc(cc1)c2ccnc3nc(nn23)N4CCN(CC4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E19 compound treatment 0.362 0.00634 0.32 0.362 0.00642 0.39 0.5034 0.9961 1908371 Bionet1_000817 Cc1nc(sc1C(=O)Nc2cccc(c2)C(F)(F)F)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E20 compound treatment 0.355 -6.56E-4 -0.03 0.349 -0.00658 -0.4 -0.3046 -0.7641 1908372 Bionet1_000818 Fc1ccc(cc1)c2ccnc3nc(SCc4c(F)cccc4Cl)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E21 compound treatment 0.387 0.0313 1.6 0.387 0.0314 1.9 2.4745 0.9965 1908373 Bionet1_000819 Cc1nc(sc1C(=O)Nc2ccc(cc2)C(F)(F)F)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E22 compound treatment 0.353 -0.00266 -0.14 0.349 -0.00658 -0.4 -0.3769 -0.8978 1908374 Bionet1_000820 Fc1cccc(Cl)c1CSc2nc3nccc(/C=C\c4ccccc4)n3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E23 positive control 0.086 -0.27 -13.79 0.085 -0.271 -16.33 -21.2999 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 E24 positive control 0.093 -0.263 -13.43 0.095 -0.261 -15.73 -20.62 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F01 mock treatment 0.352 -0.00366 -0.19 0.353 -0.00258 -0.16 -0.2424 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F02 mock treatment 0.362 0.00634 0.32 0.359 0.00342 0.21 0.3753 0.9762 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F03 compound treatment 0.354 -0.00166 -0.08 0.354 -0.00158 -0.1 -0.1274 -0.9982 1908375 Bionet1_000821 CN(C)c1nc(cc(n1)C(F)(F)F)N2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F04 compound treatment 0.356 3.44E-4 0.02 0.36 0.00442 0.27 0.2011 0.7521 1908376 Bionet1_000822 Nc1sc2CN(CCc2c1C#N)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F05 compound treatment 0.363 0.00734 0.38 0.367 0.0114 0.69 0.753 0.9592 1908377 Bionet1_000823 CN(C)c1nc(cc(n1)C(F)(F)F)N2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F06 compound treatment 0.354 -0.00166 -0.08 0.35 -0.00558 -0.34 -0.2981 -0.8582 1908378 Bionet1_000824 Cn1c(CNS(=O)(=O)c2ccc(Cl)cc2)nnc1SCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F07 compound treatment 0.371 0.0153 0.78 0.365 0.00942 0.57 0.9569 0.9875 1908379 Bionet1_000825 CN(C)c1nc(cc(n1)C(F)(F)F)N2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F08 compound treatment 0.34 -0.0157 -0.8 0.352 -0.00358 -0.22 -0.7189 -0.867 1168738 Bionet1_000826 COC(=O)CSc1nnc(CNS(=O)(=O)c2ccc(Cl)cc2)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F09 compound treatment 0.364 0.00834 0.43 0.356 4.19E-4 0.03 0.3196 0.7477 1297873 Bionet1_000827 Clc1ccc(cc1Cl)N2CCN(CC2)c3nnnn3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F10 compound treatment 0.356 3.44E-4 0.02 0.356 4.19E-4 0.03 0.0303 0.9841 1908380 Bionet1_000828 CSc1nnc(CNS(=O)(=O)c2ccc(Br)cc2)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F11 compound treatment 0.368 0.0123 0.63 0.365 0.00942 0.57 0.8484 0.9986 1229343 Bionet1_000829 Clc1ccc(cc1Cl)N2CCN(CC2)c3cnc4ccccc4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F12 compound treatment 0.342 -0.0137 -0.7 0.341 -0.0146 -0.88 -1.1162 -0.9934 1666889 Bionet1_000830 CCC(C)Sc1nnc(CNS(=O)(=O)c2ccc(F)cc2)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F13 compound treatment 0.358 0.00234 0.12 0.356 4.19E-4 0.03 0.1026 0.838 1908381 Bionet1_000831 Cn1nc(c(C#N)c1N2CCN(CC2)c3ccc(F)cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F14 compound treatment 0.514 0.158 8.1 0.517 0.161 9.74 12.6156 0.9958 1908382 Bionet1_000832 [O-][N+](=O)c1ccc(cc1)N2CCc3nn(cc3C2)c4cccc(Cl)n4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F15 compound treatment 0.356 3.44E-4 0.02 0.353 -0.00258 -0.16 -0.0977 -0.6234 1908383 Bionet1_000833 Cn1nc(c(C#N)c1N2CCN(CC2)c3ccccc3F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F16 compound treatment 0.355 -6.56E-4 -0.03 0.357 0.00142 0.09 0.0369 0.4006 1908384 Bionet1_000834 COc1ccc(NC(=O)CS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F17 compound treatment 0.352 -0.00366 -0.19 0.354 -0.00158 -0.1 -0.1997 -0.9513 1908385 Bionet1_000835 COc1cccc(c1)N2CCN(CC2)c3c(C#N)c(nn3C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F18 compound treatment 0.353 -0.00266 -0.14 0.354 -0.00158 -0.1 -0.1635 -0.9851 1908386 Bionet1_000836 COc1ccc(NC(=O)CS(=O)c2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F19 compound treatment 0.358 0.00234 0.12 0.361 0.00542 0.33 0.3161 0.9072 1908387 Bionet1_000837 CCOC(=O)NC(=O)c1cn(OCc2ccc(Cl)cc2)c(=O)[nH]c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F20 compound treatment 0.358 0.00234 0.12 0.362 0.00642 0.39 0.3588 0.8845 1908388 Bionet1_000838 COc1ccc(NC(=O)CS(=O)c2cccc(c2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F21 compound treatment 0.358 0.00234 0.12 0.356 4.19E-4 0.03 0.1026 0.838 1908389 Bionet1_000839 FC(F)(F)c1cccc(c1)C(=O)OCCn2cc(C#N)c(=O)[nH]c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F22 compound treatment 0.352 -0.00366 -0.19 0.353 -0.00258 -0.16 -0.2424 -0.9959 1908390 Bionet1_000840 COc1ccc(NC(=O)CS(=O)(=O)c2cccc(c2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F23 positive control 0.088 -0.268 -13.69 0.086 -0.27 -16.27 -21.1849 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 F24 positive control 0.093 -0.263 -13.43 0.091 -0.265 -15.97 -20.7907 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G01 mock treatment 0.352 -0.00366 -0.19 0.35 -0.00558 -0.34 -0.3704 -0.9614 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G02 mock treatment 0.353 -0.00266 -0.14 0.35 -0.00558 -0.34 -0.3343 -0.9202 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G03 compound treatment 0.351 -0.00466 -0.24 0.348 -0.00758 -0.46 -0.4919 -0.9536 1908391 Bionet1_000841 COC(=O)c1ccc(cc1)c2nc(cs2)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G04 compound treatment 0.361 0.00534 0.27 0.359 0.00342 0.21 0.3392 0.9904 1908392 Bionet1_000842 Fc1cccc(Cl)c1CSc2nc3nccc(c4ccccn4)n3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G05 compound treatment 0.366 0.0103 0.53 0.366 0.0104 0.63 0.8188 0.9963 1908393 Bionet1_000843 Cc1nc(sc1C(=O)Nc2ccc(Br)cc2)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G06 compound treatment 0.354 -0.00166 -0.08 0.357 0.00142 0.09 7.0E-4 0.0058 1908394 Bionet1_000844 C(Sc1nc2nccc(/C=C\c3ccccc3)n2n1)/C=C/c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G07 compound treatment 0.354 -0.00166 -0.08 0.345 -0.0106 -0.64 -0.5115 -0.7939 1353051 Bionet1_000845 CCOC(=O)c1cc([nH]c1N2CCN(CC2)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G08 compound treatment 0.371 0.0153 0.78 0.356 4.19E-4 0.03 0.5727 0.7295 1908395 Bionet1_000846 Fc1ccc(cc1)c2ccnc3nc(SC/C=C/c4ccccc4)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G09 compound treatment 0.361 0.00534 0.27 0.359 0.00342 0.21 0.3392 0.9904 1599578 Bionet1_000847 COc1ccc(cc1)N2CCN(CC2)c3[nH]c(cc3C#N)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G10 compound treatment 0.345 -0.0107 -0.54 0.344 -0.0116 -0.7 -0.8796 -0.9924 1908396 Bionet1_000848 COc1ccc(cc1)c2cnc3nc(SC/C=C/c4ccccc4)nn3c2N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G11 compound treatment 0.364 0.00834 0.43 0.366 0.0104 0.63 0.7464 0.9821 1908397 Bionet1_000849 Cc1nc(sc1C(=O)Nc2ccc(OC(F)(F)F)cc2)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G12 compound treatment 0.376 0.0203 1.04 0.371 0.0154 0.93 1.3938 0.9985 1908398 Bionet1_000850 Nc1c(cnc2nc(SC/C=C/c3ccccc3)nn12)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G13 compound treatment 0.361 0.00534 0.27 0.36 0.00442 0.27 0.3819 0.9999 1908399 Bionet1_000851 CNC(=O)c1ccc(cc1)c2nc(cs2)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G14 compound treatment 0.392 0.0363 1.86 0.394 0.0384 2.32 2.954 0.994 1908400 Bionet1_000852 COc1ccc(cc1)c2ccnc3nc(SC/C=C/c4ccccc4)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G15 compound treatment 0.359 0.00334 0.17 0.362 0.00642 0.39 0.3949 0.9324 1908401 Bionet1_000853 FC(F)(F)c1cccc(c1)c2csc(n2)c3ccc(cc3)C(=O)NCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G16 compound treatment 0.365 0.00934 0.48 0.373 0.0174 1.05 1.0814 0.9363 1908402 Bionet1_000854 CN(C)/C=C/C(=O)c1cccc(Oc2ncc(cc2Cl)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G17 compound treatment 0.374 0.0183 0.94 0.383 0.0274 1.66 1.8337 0.9638 1179349 Bionet1_000855 CCOC(=O)c1cc([nH]c1N2CCOCC2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G18 compound treatment 0.421 0.0653 3.34 0.43 0.0744 4.49 5.5393 0.9894 1908403 Bionet1_000856 CO/N=C/C(=C\Nc1ccc(Cl)cc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G19 compound treatment 0.356 3.44E-4 0.02 0.354 -0.00158 -0.1 -0.055 -0.5673 1152475 Bionet1_000857 Clc1ccc(cc1)c2csc(n2)c3ccc(cc3)C(=O)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G20 compound treatment 0.408 0.0523 2.68 0.418 0.0624 3.77 4.557 0.986 1908404 Bionet1_000858 FC(F)(F)c1cccc(N/C=C/c2ncc(cc2Cl)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G21 compound treatment 0.37 0.0143 0.73 0.361 0.00542 0.33 0.7499 0.9338 1908405 Bionet1_000859 CN(C)CCCNC(=O)c1ccc(cc1)c2nc(cs2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G22 compound treatment 0.345 -0.0107 -0.54 0.342 -0.0136 -0.82 -0.965 -0.9803 1908406 Bionet1_000860 FC(F)(F)c1cnc(C/C=N\OCc2c(Cl)cccc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G23 positive control 0.089 -0.267 -13.63 0.088 -0.268 -16.15 -21.0634 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 G24 positive control 0.097 -0.259 -13.23 0.097 -0.259 -15.61 -20.39 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H01 mock treatment 0.357 0.00134 0.07 0.358 0.00242 0.15 0.1519 0.9408 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H02 mock treatment 0.358 0.00234 0.12 0.356 4.19E-4 0.03 0.1026 0.838 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H03 compound treatment 0.357 0.00134 0.07 0.357 0.00142 0.09 0.1092 0.994 1908407 Bionet1_000861 C/C(=N\Nc1ncc(cc1Cl)C(F)(F)F)/c2cn(C)c(=O)n(C)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H04 compound treatment 0.373 0.0173 0.89 0.37 0.0144 0.87 1.2426 1.0 1908408 Bionet1_000862 COc1ccc(NC(=O)CSc2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H05 compound treatment 0.371 0.0153 0.78 0.373 0.0174 1.05 1.2983 0.9896 1197912 Bionet1_000863 COc1ccc(cc1)n2cc(C#N)c(=O)n(Cc3ccc(F)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H06 compound treatment 0.362 0.00634 0.32 0.36 0.00442 0.27 0.418 0.9953 1908409 Bionet1_000864 COc1ccc(NC(=O)CS(=O)(=O)c2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H07 compound treatment 0.35 -0.00566 -0.29 0.346 -0.00958 -0.58 -0.6135 -0.9487 1908410 Bionet1_000865 CN(c1ncc(cc1Cl)C(F)(F)F)n2cc(C(=O)C)c(=O)[nH]c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H08 compound treatment 0.357 0.00134 0.07 0.361 0.00542 0.33 0.2799 0.8373 1908411 Bionet1_000866 Clc1ccc(NC(=O)C/C=N\OCc2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H09 compound treatment 0.345 -0.0107 -0.54 0.354 -0.00158 -0.1 -0.4528 -0.8185 1908412 Bionet1_000867 CC(=O)c1cn(CCNc2ncc(cc2Cl)C(F)(F)F)c(=O)[nH]c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H10 compound treatment 0.364 0.00834 0.43 0.369 0.0134 0.81 0.8745 0.9551 1908413 Bionet1_000868 Clc1ccc(NC(=O)C/C=N\OCc2ccc(Cl)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H11 compound treatment 0.354 -0.00166 -0.08 0.356 4.19E-4 0.03 -0.042 -0.475 1908414 Bionet1_000869 CN1CCN(CC1)n2cc(C(=O)C)c(=O)n(Cc3ccc(F)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H12 compound treatment 0.345 -0.0107 -0.54 0.343 -0.0126 -0.76 -0.9223 -0.9867 1908415 Bionet1_000870 [O-][N+](=O)c1ccc(CO/N=C\CC(=O)Nc2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H13 compound treatment 0.36 0.00434 0.22 0.356 4.19E-4 0.03 0.175 0.7826 1908416 Bionet1_000871 CC(=O)c1cn(Cc2ccccc2)c(=O)n(Cc3ccc(F)cc3)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H14 compound treatment 0.361 0.00534 0.27 0.361 0.00542 0.33 0.4245 0.996 1908417 Bionet1_000872 Clc1ccc(NC(=O)C/C=N\OC(=O)Nc2ccccc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H15 compound treatment 0.364 0.00834 0.43 0.369 0.0134 0.81 0.8745 0.9551 1908418 Bionet1_000873 CC(=O)c1cn(c2ccc(Cl)cc2)c(=O)n(Cc3ccc(F)cc3)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H16 compound treatment 0.377 0.0213 1.09 0.377 0.0214 1.29 1.686 0.9964 1908419 Bionet1_000874 Clc1ccc(NC(=O)C/C=N\OCc2c(Cl)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H17 compound treatment 0.365 0.00934 0.48 0.366 0.0104 0.63 0.7826 0.9908 1908420 Bionet1_000875 Cn1c(=O)c(C#N)cn(CCNc2ncc(cc2Cl)C(F)(F)F)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H18 compound treatment 0.358 0.00234 0.12 0.365 0.00942 0.57 0.4868 0.8377 1908421 Bionet1_000876 [O-][N+](=O)c1ccc(CO/N=C\CC(=O)Nc2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H19 compound treatment 0.349 -0.00666 -0.34 0.358 0.00242 0.15 -0.1374 -0.371 1908422 Bionet1_000877 FC(F)(F)c1cnc(NCCn2cc(C#N)c(=O)[nH]c2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H20 compound treatment 0.366 0.0103 0.53 0.369 0.0134 0.81 0.9468 0.9787 1908423 Bionet1_000878 Fc1ccc(NC(=O)C/C=N\OCc2ccc(Cl)cc2Cl)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H21 compound treatment 0.356 3.44E-4 0.02 0.359 0.00342 0.21 0.1584 0.7646 1908424 Bionet1_000879 CCOC(=O)NC(=O)/C(=C\NNc1ncc(cc1Cl)C(F)(F)F)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H22 compound treatment 0.37 0.0143 0.73 0.371 0.0154 0.93 1.1768 0.993 1908425 Bionet1_000880 Fc1ccc(NC(=O)C/C=N\OCc2ccc(Cl)c(Cl)c2)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H23 positive control 0.087 -0.269 -13.74 0.086 -0.27 -16.27 -21.2211 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 H24 positive control 0.096 -0.26 -13.28 0.096 -0.26 -15.67 -20.4688 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I01 mock treatment 0.357 0.00134 0.07 0.357 0.00142 0.09 0.1092 0.994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I02 mock treatment 0.36 0.00434 0.22 0.356 4.19E-4 0.03 0.175 0.7826 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I03 compound treatment 0.362 0.00634 0.32 0.361 0.00542 0.33 0.4607 1.0 1153565 Bionet1_000881 CNC(=O)c1ccc(cc1)c2nc(cs2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I04 compound treatment 0.402 0.0463 2.37 0.399 0.0434 2.62 3.529 0.9987 1908426 Bionet1_000882 FC(F)(F)c1cnc(/C=C/Nc2ccccc2Oc3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I05 compound treatment 0.359 0.00334 0.17 0.353 -0.00258 -0.16 0.0107 0.0464 1317106 Bionet1_000883 Clc1ccc(cc1Cl)c2csc(n2)c3ccc(cc3)C(=O)NCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I06 compound treatment 0.42 0.0643 3.29 0.41 0.0544 3.29 4.6494 1.0 1908427 Bionet1_000884 CO/N=C/C(=C\Nc1ccccc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I07 compound treatment 0.347 -0.00866 -0.44 0.35 -0.00558 -0.34 -0.5512 -0.9909 1908428 Bionet1_000885 CCOC(=O)c1cc([nH]c1NNC(=O)c2ccccc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I08 compound treatment 0.403 0.0473 2.42 0.408 0.0524 3.16 3.9494 0.9913 1908429 Bionet1_000886 CO/N=C/C(=C\Nc1ccc(F)cc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I09 compound treatment 0.387 0.0313 1.6 0.385 0.0294 1.78 2.3891 0.9987 1601031 Bionet1_000887 CCOC(=O)c1cc([nH]c1Nc2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I10 compound treatment 0.426 0.0703 3.6 0.418 0.0624 3.77 5.2078 0.9997 1908430 Bionet1_000888 CO/N=C/C(=C\Nc1ccc(OC)cc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I11 compound treatment 0.382 0.0263 1.35 0.391 0.0354 2.14 2.4644 0.9752 1908431 Bionet1_000889 CCOC(=O)c1cc([nH]c1Nc2ccc(C)cc2)c3cccc(c3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I12 compound treatment 0.343 -0.0127 -0.65 0.347 -0.00858 -0.52 -0.8239 -0.9939 1908432 Bionet1_000890 FC(F)(F)c1cnc(C(C#N)c2c(Cl)cccc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I13 compound treatment 0.411 0.0553 2.83 0.417 0.0614 3.71 4.6228 0.9911 1266304 Bionet1_000891 O=C(c1cc(C#N)c([nH]1)N2CCN(CC2)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I14 compound treatment 0.353 -0.00266 -0.14 0.361 0.00542 0.33 0.1353 0.3819 1908433 Bionet1_000892 COc1ccc(cc1OC)C(C#N)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I15 compound treatment 0.375 0.0193 0.99 0.368 0.0124 0.75 1.2295 0.9907 1908434 Bionet1_000893 CCOC(=O)C(=CNc1c[nH]c(C)c1C(=O)c2ccccc2)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I16 compound treatment 0.344 -0.0117 -0.6 0.361 0.00542 0.33 -0.1901 -0.2796 1908435 Bionet1_000894 NC(=O)C(c1cccc(c1)C(F)(F)F)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I17 compound treatment 0.391 0.0353 1.81 0.414 0.0584 3.53 3.7716 0.9518 1908436 Bionet1_000895 CCOC(=O)C(=CNc1cn(C)c(C)c1C(=O)c2ccccc2)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I18 compound treatment 0.358 0.00234 0.12 0.357 0.00142 0.09 0.1453 0.9865 1908437 Bionet1_000896 COc1ccc(cc1OC)C(C(=O)N)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I19 compound treatment 0.43 0.0743 3.8 0.414 0.0584 3.53 5.1817 0.9993 1430706 Bionet1_000897 O=C(c1cc(C#N)c([nH]1)N2CCN(CC2)c3ccccn3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I20 compound treatment 0.355 -6.56E-4 -0.03 0.358 0.00242 0.15 0.0795 0.5308 1908438 Bionet1_000898 FC(F)(F)c1cnc(C(C#N)c2ccc(Cl)cc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I21 compound treatment 0.388 0.0323 1.65 0.395 0.0394 2.38 2.8521 0.9842 1710693 Bionet1_000899 CCOC(=O)c1cc([nH]c1Nc2ccc(Cl)cc2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I22 compound treatment 0.355 -6.56E-4 -0.03 0.352 -0.00358 -0.22 -0.1766 -0.8072 1908439 Bionet1_000900 NC(=O)C(c1ncc(cc1Cl)C(F)(F)F)c2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I23 positive control 0.09 -0.266 -13.58 0.092 -0.264 -15.91 -20.8565 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 I24 positive control 0.096 -0.26 -13.28 0.097 -0.259 -15.61 -20.4261 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J01 mock treatment 0.357 0.00134 0.07 0.355 -5.81E-4 -0.04 0.0238 0.3085 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J02 mock treatment 0.363 0.00734 0.38 0.362 0.00642 0.39 0.5395 0.9999 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J03 compound treatment 0.417 0.0613 3.14 0.41 0.0544 3.29 4.5409 0.9997 1908440 Bionet1_000901 Cn1c(ccc1/C(=C/c2ccc(Cl)cc2)/C#N)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J04 compound treatment 0.356 3.44E-4 0.02 0.356 4.19E-4 0.03 0.0303 0.9841 1908441 Bionet1_000902 Fc1ccc(NC(=O)C/C=N\OCc2c(Cl)cccc2Cl)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J05 compound treatment 0.338 -0.0177 -0.9 0.339 -0.0166 -1.0 -1.3462 -0.9987 1908442 Bionet1_000903 COC(=O)C(NS(=O)(=O)c1cccc(c1)C(F)(F)F)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J06 compound treatment 0.356 3.44E-4 0.02 0.359 0.00342 0.21 0.1584 0.7646 1908443 Bionet1_000904 CSc1nc(NC(=O)C/C=N\OCc2ccc(cc2)[N+](=O)[O-])nn1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J07 compound treatment 0.37 0.0143 0.73 0.373 0.0174 1.05 1.2622 0.9845 1514688 Bionet1_000905 CS(=O)(=O)c1ccc(C(=O)Nc2ccc(cc2)N3CCCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J08 compound treatment 0.344 -0.0117 -0.6 0.349 -0.00658 -0.4 -0.7024 -0.9806 1908444 Bionet1_000906 Clc1ccc(cc1)S(=O)(=O)C/C=N/OCc2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J09 compound treatment 0.362 0.00634 0.32 0.363 0.00742 0.45 0.5461 0.9874 1151626 Bionet1_000907 CCCCC(=O)Nc1ccc(cc1)N2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J10 compound treatment 0.342 -0.0137 -0.7 0.336 -0.0196 -1.18 -1.3296 -0.9685 1908445 Bionet1_000908 Clc1ccc(OC(=O)C/C=N\OCc2c(Cl)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J11 compound treatment 0.356 3.44E-4 0.02 0.358 0.00242 0.15 0.1157 0.7865 1908446 Bionet1_000909 FC(F)(F)c1cccc(c1)C(=O)Nc2ccccc2N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J12 compound treatment 0.34 -0.0157 -0.8 0.338 -0.0176 -1.06 -1.3165 -0.9903 1908447 Bionet1_000910 COc1ccc(OC(=O)C/C=N\OCc2c(Cl)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J13 compound treatment 0.349 -0.00666 -0.34 0.356 4.19E-4 0.03 -0.2228 -0.6527 1418952 Bionet1_000911 CS(=O)(=O)c1ccc(C(=O)Nc2ccccc2N3CCOCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J14 compound treatment 0.362 0.00634 0.32 0.369 0.0134 0.81 0.8022 0.9193 1908448 Bionet1_000912 Clc1ccc(cc1)c2nnc(COc3ccc(Cl)cc3Cl)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J15 compound treatment 0.355 -6.56E-4 -0.03 0.348 -0.00758 -0.46 -0.3473 -0.7569 1908449 Bionet1_000913 Cc1nc(nn1c2ccc(cc2)[N+](=O)[O-])C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J16 compound treatment 0.362 0.00634 0.32 0.361 0.00542 0.33 0.4607 1.0 1908450 Bionet1_000914 CC(C)(N1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F)C(=O)N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J17 compound treatment 0.349 -0.00666 -0.34 0.347 -0.00858 -0.52 -0.6069 -0.9792 1349482 Bionet1_000915 Cc1nc(nn1c2ccc(Cl)cc2)C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J18 compound treatment 0.348 -0.00766 -0.39 0.357 0.00142 0.09 -0.2162 -0.5396 1908451 Bionet1_000916 COc1cccc2C=C(COc12)C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J19 compound treatment 0.363 0.00734 0.38 0.381 0.0254 1.53 1.3506 0.8549 1908452 Bionet1_000917 Cc1nc(nn1c2ccc(cc2)[N+](=O)[O-])C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J20 compound treatment 0.368 0.0123 0.63 0.374 0.0184 1.11 1.2326 0.964 1908453 Bionet1_000918 COc1cccc2C=C(COc12)C(=O)Nc3ccc(OC(F)(F)F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J21 compound treatment 0.353 -0.00266 -0.14 0.354 -0.00158 -0.1 -0.1635 -0.9851 1908454 Bionet1_000919 Cc1nc(nn1c2ccc(cc2)[N+](=O)[O-])C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J22 compound treatment 0.356 3.44E-4 0.02 0.358 0.00242 0.15 0.1157 0.7865 1908455 Bionet1_000920 COc1cccc2C=C(COc12)C(=O)NCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J23 positive control 0.088 -0.268 -13.69 0.091 -0.265 -15.97 -20.9715 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 J24 positive control 0.096 -0.26 -13.28 0.098 -0.258 -15.55 -20.3835 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K01 mock treatment 0.358 0.00234 0.12 0.362 0.00642 0.39 0.3588 0.8845 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K02 mock treatment 0.357 0.00134 0.07 0.352 -0.00358 -0.22 -0.1043 -0.4597 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K03 compound treatment 0.355 -6.56E-4 -0.03 0.355 -5.81E-4 -0.04 -0.0485 -0.9998 1908456 Bionet1_000921 Cn1nc(c(CO)c1Sc2ccc(Br)cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K04 compound treatment 0.346 -0.00966 -0.49 0.351 -0.00458 -0.28 -0.5447 -0.9625 1908457 Bionet1_000922 NC(=O)C(c1ccc(Cl)cc1Cl)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K05 compound treatment 0.361 0.00534 0.27 0.361 0.00542 0.33 0.4245 0.996 1908458 Bionet1_000923 CC(=O)OCc1c(nn(C)c1S(=O)(=O)c2ccc(Cl)cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K06 compound treatment 0.365 0.00934 0.48 0.359 0.00342 0.21 0.4838 0.9296 1908459 Bionet1_000924 FC(F)(F)c1cnc(N2CCC(CC2)C(=O)N3CCCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K07 compound treatment 0.344 -0.0117 -0.6 0.347 -0.00858 -0.52 -0.7877 -0.9976 1908460 Bionet1_000925 Cn1nc(c(CO)c1S(=O)(=O)c2ccc(Cl)cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K08 compound treatment 0.334 -0.0217 -1.11 0.35 -0.00558 -0.34 -1.0212 -0.8823 1908461 Bionet1_000926 FC(F)(F)c1cnc(N2CCC(CC2)C(=O)N3CCOCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K09 compound treatment 0.341 -0.0147 -0.75 0.341 -0.0146 -0.88 -1.1523 -0.9968 1908462 Bionet1_000927 Cn1nc(c(CO)c1S(=O)(=O)c2ccc(Br)cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K10 compound treatment 0.349 -0.00666 -0.34 0.363 0.00742 0.45 0.076 0.1352 1908463 Bionet1_000928 FC(F)(F)c1cnc(N2CCC(CC2)C(=O)N3CCCCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K11 compound treatment 0.357 0.00134 0.07 0.347 -0.00858 -0.52 -0.3177 -0.608 1908464 Bionet1_000929 Cc1ccnc(N/C=C(/NC(=O)c2ccccc2)\C(=O)N/N=C\c3ccccc3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K12 compound treatment 0.347 -0.00866 -0.44 0.35 -0.00558 -0.34 -0.5512 -0.9909 1908465 Bionet1_000930 CN(CCO)C(=O)C1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K13 compound treatment 0.358 0.00234 0.12 0.349 -0.00658 -0.4 -0.1962 -0.4728 1908466 Bionet1_000931 FC(F)(F)c1cnc(CON2C(=O)c3ccccc3C2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K14 compound treatment 0.348 -0.00766 -0.39 0.352 -0.00358 -0.22 -0.4297 -0.9608 1908467 Bionet1_000932 CN1CCN(CC1)C(=O)C2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K15 compound treatment 0.359 0.00334 0.17 0.358 0.00242 0.15 0.2242 0.9969 1908468 Bionet1_000933 Cn1c(SCc2ccccc2)nnc1c3csc(n3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K16 compound treatment 0.356 3.44E-4 0.02 0.363 0.00742 0.45 0.3291 0.7343 1378992 Bionet1_000934 Cc1ccc(cc1)S(=O)(=O)c2ccc(NC(=O)c3c(F)cccc3F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K17 compound treatment 0.357 0.00134 0.07 0.362 0.00642 0.39 0.3226 0.8197 1908469 Bionet1_000935 Clc1ccc(CSc2nnc(o2)c3csc(n3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K18 compound treatment 0.364 0.00834 0.43 0.363 0.00742 0.45 0.6184 0.9997 1908470 Bionet1_000936 Fc1ccc(cc1)C(=O)Nc2ccc(Sc3cccc(c3)C(F)(F)F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K19 compound treatment 0.36 0.00434 0.22 0.357 0.00142 0.09 0.2176 0.9142 1908471 Bionet1_000937 CN(C)c1nc(Sc2ccc(Cl)c(Cl)c2)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K20 compound treatment 0.356 3.44E-4 0.02 0.357 0.00142 0.09 0.073 0.8348 1908472 Bionet1_000938 COC(=O)/C(=C\Nc1ccc(Cl)cc1Cl)/NC(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K21 compound treatment 0.353 -0.00266 -0.14 0.349 -0.00658 -0.4 -0.3769 -0.8978 1908473 Bionet1_000939 CN(C)c1nc(Sc2ccc(Br)cc2)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K22 compound treatment 0.351 -0.00466 -0.24 0.354 -0.00158 -0.1 -0.2358 -0.9194 1908474 Bionet1_000940 COC(=O)/C(=C\Nc1ccc(OC)cc1)/NC(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K23 positive control 0.088 -0.268 -13.69 0.088 -0.268 -16.15 -21.0996 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 K24 positive control 0.099 -0.257 -13.12 0.098 -0.258 -15.55 -20.275 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L01 mock treatment 0.358 0.00234 0.12 0.356 4.19E-4 0.03 0.1026 0.838 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L02 mock treatment 0.358 0.00234 0.12 0.357 0.00142 0.09 0.1453 0.9865 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L03 compound treatment 0.356 3.44E-4 0.02 0.357 0.00142 0.09 0.073 0.8348 1908475 Bionet1_000941 COc1ccc(NC(=O)c2nc(C)n(n2)c3ccc(cc3)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L04 compound treatment 0.363 0.00734 0.38 0.355 -5.81E-4 -0.04 0.2407 0.6383 1908476 Bionet1_000942 COc1ccc2OCC(=Cc2c1)C(=O)NCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L05 compound treatment 0.362 0.00634 0.32 0.357 0.00142 0.09 0.29 0.8642 1908477 Bionet1_000943 Clc1ccc(CC(=O)c2c[nH]c(c2)C(=O)C(Cl)(Cl)Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L06 compound treatment 0.368 0.0123 0.63 0.364 0.00842 0.51 0.8057 0.9942 1908478 Bionet1_000944 Cc1ccc(cc1)n2cc3CN(CCc3n2)c4ncc(cc4Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L07 compound treatment 0.357 0.00134 0.07 0.352 -0.00358 -0.22 -0.1043 -0.4597 1908479 Bionet1_000945 CCOC(=O)c1c(N)onc1OCCOC(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L08 compound treatment 0.358 0.00234 0.12 0.349 -0.00658 -0.4 -0.1962 -0.4728 1908480 Bionet1_000946 CSc1nnc(CNS(=O)(=O)c2ccc(Cl)cc2)n1CC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L09 compound treatment 0.362 0.00634 0.32 0.361 0.00542 0.33 0.4607 1.0 1908481 Bionet1_000947 CCOC(=O)c1c(N)onc1OCCOC(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L10 compound treatment 0.35 -0.00566 -0.29 0.357 0.00142 0.09 -0.1439 -0.4771 1908482 Bionet1_000948 Clc1ccc(cc1)S(=O)(=O)NCc2nnc(SCC=C)n2CC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L11 compound treatment 0.353 -0.00266 -0.14 0.352 -0.00358 -0.22 -0.2489 -0.9749 1908483 Bionet1_000949 FC(F)(F)c1cnc(NCCNC2=CC(=O)c3ccccc3C2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L12 compound treatment 0.356 3.44E-4 0.02 0.348 -0.00758 -0.46 -0.3112 -0.6794 1908484 Bionet1_000950 CCn1c(SCC=C)nnc1C(C)NS(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L13 compound treatment 0.35 -0.00566 -0.29 0.355 -5.81E-4 -0.04 -0.2293 -0.787 1908485 Bionet1_000951 CCOC(=O)c1c(N)onc1OCCOC(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L14 compound treatment 0.353 -0.00266 -0.14 0.358 0.00242 0.15 0.0072 0.0363 1908486 Bionet1_000952 CCn1c(SC)nnc1C(C)NS(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L15 compound treatment 0.336 -0.0197 -1.01 0.341 -0.0146 -0.88 -1.3331 -0.9978 1631585 Bionet1_000953 CC(C)CC(NS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C)c(C)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L16 compound treatment 0.348 -0.00766 -0.39 0.348 -0.00758 -0.46 -0.6004 -0.997 1908487 Bionet1_000954 CN(C)S(=O)(=O)Oc1ccsc1C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L17 compound treatment 0.354 -0.00166 -0.08 0.35 -0.00558 -0.34 -0.2981 -0.8582 1479836 Bionet1_000955 CC(NS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C)c(C)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L18 compound treatment 0.349 -0.00666 -0.34 0.349 -0.00658 -0.4 -0.5216 -0.997 1908488 Bionet1_000956 CN(C)S(=O)(=O)Oc1ccsc1C(=O)Nc2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L19 compound treatment 0.356 3.44E-4 0.02 0.35 -0.00558 -0.34 -0.2258 -0.6693 1177965 Bionet1_000957 CC(NS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L20 compound treatment 0.357 0.00134 0.07 0.355 -5.81E-4 -0.04 0.0238 0.3085 1908489 Bionet1_000958 CN(C)S(=O)(=O)Oc1ccsc1C(=O)Nc2ccc(F)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L21 compound treatment 0.355 -6.56E-4 -0.03 0.357 0.00142 0.09 0.0369 0.4006 1383336 Bionet1_000959 CC(C)C(NS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc2ccc(C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L22 compound treatment 0.352 -0.00366 -0.19 0.347 -0.00858 -0.52 -0.4985 -0.9052 1908490 Bionet1_000960 CN(C)S(=O)(=O)Oc1ccsc1C(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L23 positive control 0.087 -0.269 -13.74 0.088 -0.268 -16.15 -21.1357 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 L24 positive control 0.099 -0.257 -13.12 0.097 -0.259 -15.61 -20.3177 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M01 mock treatment 0.356 3.44E-4 0.02 0.356 4.19E-4 0.03 0.0303 0.9841 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M02 mock treatment 0.358 0.00234 0.12 0.361 0.00542 0.33 0.3161 0.9072 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M03 compound treatment 0.354 -0.00166 -0.08 0.354 -0.00158 -0.1 -0.1274 -0.9982 1908491 Bionet1_000961 CN(C)c1nc(Oc2cccc(Cl)c2Cl)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M04 compound treatment 0.36 0.00434 0.22 0.355 -5.81E-4 -0.04 0.1323 0.5882 1908492 Bionet1_000962 COC(=O)/C(=C\Nc1ccccc1)/NC(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M05 compound treatment 0.354 -0.00166 -0.08 0.351 -0.00458 -0.28 -0.2554 -0.8832 1908493 Bionet1_000963 CN(C)c1nc(Oc2c(Cl)cccc2Cl)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M06 compound treatment 0.359 0.00334 0.17 0.357 0.00142 0.09 0.1815 0.949 1908494 Bionet1_000964 COC(=O)/C(=C\Nc1ccc(OC)cc1)/NC(=O)c2ccc(OC)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M07 compound treatment 0.35 -0.00566 -0.29 0.354 -0.00158 -0.1 -0.272 -0.8931 1908495 Bionet1_000965 CN(C)/C=N\NC(=O)/C(=C\Nc1nccc(C)n1)/NC(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M08 compound treatment 0.367 0.0113 0.58 0.366 0.0104 0.63 0.8549 0.9992 1397124 Bionet1_000966 Cc1cccc(c1)C(=O)Nc2ccc(Sc3ccccc3Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M09 compound treatment 0.356 3.44E-4 0.02 0.357 0.00142 0.09 0.073 0.8348 1908496 Bionet1_000967 FC(F)(F)Oc1ccc(NC(=O)c2nc(Cn3cncn3)n[nH]2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M10 compound treatment 0.355 -6.56E-4 -0.03 0.356 4.19E-4 0.03 -0.0058 -0.1386 1908497 Bionet1_000968 FC(F)(F)c1cccc(c1)C(=O)Nc2ccc(cc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M11 compound treatment 0.35 -0.00566 -0.29 0.348 -0.00758 -0.46 -0.5281 -0.9755 1908498 Bionet1_000969 CCc1cccc(CC)c1NC(=O)C(F)(F)Oc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M12 compound treatment 0.374 0.0183 0.94 0.375 0.0194 1.17 1.4922 0.9939 1465528 Bionet1_000970 Clc1ccc(C(=O)Nc2ccc(cc2)N3CCOCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M13 compound treatment 0.357 0.00134 0.07 0.357 0.00142 0.09 0.1092 0.994 1908499 Bionet1_000971 FC(F)(F)c1cccc(OC(F)(F)C(=O)Nc2c(Cl)cccc2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M14 compound treatment 0.358 0.00234 0.12 0.361 0.00542 0.33 0.3161 0.9072 1345249 Bionet1_000972 CS(=O)(=O)c1ccc(C(=O)Nc2ccc(cc2)N3CCOCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M15 compound treatment 0.348 -0.00766 -0.39 0.344 -0.0116 -0.7 -0.7712 -0.9624 1908500 Bionet1_000973 Cc1ccc(NC(=O)C(F)(F)Oc2cccc(c2)C(F)(F)F)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M16 compound treatment 0.349 -0.00666 -0.34 0.351 -0.00458 -0.28 -0.4362 -0.9947 1908501 Bionet1_000974 CN1CCN(CC1)c2ccc(NC(=O)c3cccc(c3)C(F)(F)F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M17 compound treatment 0.336 -0.0197 -1.01 0.348 -0.00758 -0.46 -1.0343 -0.9366 1908502 Bionet1_000975 FC(F)(F)c1ccc(NC(=O)C(F)(F)Oc2cccc(c2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M18 compound treatment 0.372 0.0163 0.84 0.37 0.0144 0.87 1.2064 0.9998 1423200 Bionet1_000976 Fc1ccc(cc1)C(=O)Nc2ccc(cc2)N3CCN(Cc4ccccc4)CC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M19 compound treatment 0.337 -0.0187 -0.95 0.346 -0.00958 -0.58 -1.0835 -0.9713 1908503 Bionet1_000977 Fc1ccc(OC(F)(F)C(=O)Nc2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M20 compound treatment 0.364 0.00834 0.43 0.36 0.00442 0.27 0.4903 0.9744 1908504 Bionet1_000978 ClC(Cl)C(=O)Nc1ccc(cc1)N2CCN(Cc3ccccc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M21 compound treatment 0.357 0.00134 0.07 0.355 -5.81E-4 -0.04 0.0238 0.3085 1908505 Bionet1_000979 Fc1ccc(OC(F)(F)C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M22 compound treatment 0.364 0.00834 0.43 0.363 0.00742 0.45 0.6184 0.9997 1908506 Bionet1_000980 O/N=C(\Sc1ccc(Cl)cc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M23 positive control 0.091 -0.265 -13.53 0.089 -0.267 -16.09 -20.9484 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 M24 positive control 0.096 -0.26 -13.28 0.095 -0.261 -15.73 -20.5115 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N01 mock treatment 0.35 -0.00566 -0.29 0.35 -0.00558 -0.34 -0.4427 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N02 mock treatment 0.356 3.44E-4 0.02 0.356 4.19E-4 0.03 0.0303 0.9841 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N03 compound treatment 0.357 0.00134 0.07 0.353 -0.00258 -0.16 -0.0616 -0.3616 1908507 Bionet1_000981 Cc1nc(nn1c2ccc(Cl)cc2)C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N04 compound treatment 0.367 0.0113 0.58 0.362 0.00642 0.39 0.6842 0.9808 1908508 Bionet1_000982 CN(C)S(=O)(=O)Oc1ccsc1C(=O)Nc2ccc(cc2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N05 compound treatment 0.361 0.00534 0.27 0.36 0.00442 0.27 0.3819 0.9999 1119468 Bionet1_000983 Cc1nc(nn1c2ccc(Cl)cc2)C(=O)Nc3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N06 compound treatment 0.351 -0.00466 -0.24 0.349 -0.00658 -0.4 -0.4493 -0.97 1908509 Bionet1_000984 CN(C)S(=O)(=O)Oc1ccsc1C(=O)Nc2cccc(Cl)c2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N07 compound treatment 0.348 -0.00766 -0.39 0.343 -0.0126 -0.76 -0.8138 -0.9525 1908510 Bionet1_000985 Cc1nc(nn1c2cccc(c2)C(F)(F)F)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N08 compound treatment 0.358 0.00234 0.12 0.358 0.00242 0.15 0.188 0.9952 1908511 Bionet1_000986 CN(C)/C=C(/C(=O)c1ccc(Cl)cc1)\S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N09 compound treatment 0.35 -0.00566 -0.29 0.347 -0.00858 -0.52 -0.5708 -0.9621 1908512 Bionet1_000987 Cc1nc(nn1c2cccc(c2)C(F)(F)F)C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N10 compound treatment 0.362 0.00634 0.32 0.358 0.00242 0.15 0.3326 0.9351 1456380 Bionet1_000988 Clc1ccc(cc1)c2c(cnn2c3ccccc3)S(=O)(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N11 compound treatment 0.349 -0.00666 -0.34 0.35 -0.00558 -0.34 -0.4789 -1.0 1908513 Bionet1_000989 Cc1nc(nn1c2cccc(c2)C(F)(F)F)C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N12 compound treatment 0.357 0.00134 0.07 0.359 0.00342 0.21 0.1945 0.8942 1908514 Bionet1_000990 CN(C)/C=C(/C(=O)c1ccc(F)cc1)\S(=O)(=O)c2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N13 compound treatment 0.359 0.00334 0.17 0.36 0.00442 0.27 0.3095 0.9769 1908515 Bionet1_000991 Cc1nc(nn1c2cccc(c2)C(F)(F)F)C(=O)Nc3ccc(F)c(F)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N14 compound treatment 0.358 0.00234 0.12 0.358 0.00242 0.15 0.188 0.9952 1638945 Bionet1_000992 COc1ccc(cc1)c2c(cnn2c3ccccc3)S(=O)(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N15 compound treatment 0.352 -0.00366 -0.19 0.358 0.00242 0.15 -0.0289 -0.1219 1206788 Bionet1_000993 Cc1nc(nn1c2ccc(F)cc2F)C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N16 compound treatment 0.352 -0.00366 -0.19 0.348 -0.00758 -0.46 -0.4558 -0.922 1732410 Bionet1_000994 Fc1ccc(cc1)c2c(cnn2c3ccccc3)S(=O)(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N17 compound treatment 0.352 -0.00366 -0.19 0.351 -0.00458 -0.28 -0.3277 -0.9818 1908516 Bionet1_000995 Cc1nc(nn1c2ccc(F)cc2F)C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N18 compound treatment 0.359 0.00334 0.17 0.359 0.00342 0.21 0.2669 0.9956 1908517 Bionet1_000996 CN(C)/C=C(/C(=O)c1ccc(Cl)c(Cl)c1)\S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N19 compound treatment 0.348 -0.00766 -0.39 0.348 -0.00758 -0.46 -0.6004 -0.997 1319951 Bionet1_000997 Cc1nc(nn1c2ccc(F)cc2F)C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N20 compound treatment 0.358 0.00234 0.12 0.357 0.00142 0.09 0.1453 0.9865 1908518 Bionet1_000998 CN(C)/C=C(/C(=O)c1ccccc1Cl)\S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N21 compound treatment 0.363 0.00734 0.38 0.365 0.00942 0.57 0.6676 0.9797 1908519 Bionet1_000999 Cc1nc(nn1c2ccc(F)cc2)C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N22 compound treatment 0.358 0.00234 0.12 0.358 0.00242 0.15 0.188 0.9952 1908520 Bionet1_001000 OC1CON(C1)C(=O)CN2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N23 positive control 0.091 -0.265 -13.53 0.09 -0.266 -16.03 -20.9057 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 N24 positive control 0.097 -0.259 -13.23 0.096 -0.26 -15.67 -20.4327 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O01 mock treatment 0.374 0.0183 0.94 0.368 0.0124 0.75 1.1934 0.9938 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O02 mock treatment 0.367 0.0113 0.58 0.356 4.19E-4 0.03 0.428 0.7373 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O03 compound treatment 0.363 0.00734 0.38 0.358 0.00242 0.15 0.3688 0.9153 1908521 Bionet1_001001 Cc1ccc(NC(=O)C(F)(F)Oc2ccc(Cl)cc2C)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O04 compound treatment 0.363 0.00734 0.38 0.359 0.00342 0.21 0.4115 0.9603 1908522 Bionet1_001002 O/N=C(/Nc1ccc(Cl)cc1)\c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O05 compound treatment 0.364 0.00834 0.43 0.363 0.00742 0.45 0.6184 0.9997 1322362 Bionet1_001003 Clc1ccc(C(C#N)c2ccc(Sc3ccccc3)nn2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O06 compound treatment 0.361 0.00534 0.27 0.359 0.00342 0.21 0.3392 0.9904 1908523 Bionet1_001004 FC(F)(F)c1cnc(C2=C(COC2=O)c3ccc(Cl)cc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O07 compound treatment 0.349 -0.00666 -0.34 0.346 -0.00958 -0.58 -0.6496 -0.968 1522054 Bionet1_001005 NC(=O)C(c1ccc(Sc2ccccc2)nn1)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O08 compound treatment 0.356 3.44E-4 0.02 0.357 0.00142 0.09 0.073 0.8348 1908524 Bionet1_001006 CC(=O)C(/C=N/OCc1ccc(cc1)[N+](=O)[O-])C(=O)Nc2nccs2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O09 compound treatment 0.358 0.00234 0.12 0.361 0.00542 0.33 0.3161 0.9072 1157065 Bionet1_001007 Clc1ccc(C(C#N)c2ccc(Nc3ccccc3)nn2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O10 compound treatment 0.355 -6.56E-4 -0.03 0.356 4.19E-4 0.03 -0.0058 -0.1386 1908525 Bionet1_001008 COC(=O)/C(=C\Nc1cccc(c1)C(F)(F)F)/NC(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O11 compound treatment 0.356 3.44E-4 0.02 0.355 -5.81E-4 -0.04 -0.0124 -0.3151 1908526 Bionet1_001009 CCc1cccc(CC)c1NC(=O)C(F)(F)Oc2ccc(Cl)cc2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O12 compound treatment 0.367 0.0113 0.58 0.368 0.0124 0.75 0.9403 0.992 1908527 Bionet1_001010 COC(=O)/C(=C\Nc1ccc(Oc2ccccc2)cc1)/NC(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O13 compound treatment 0.367 0.0113 0.58 0.363 0.00742 0.45 0.7269 0.9918 1908528 Bionet1_001011 NOCC(=O)N1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O14 compound treatment 0.367 0.0113 0.58 0.367 0.0114 0.69 0.8976 0.9963 1609013 Bionet1_001012 Fc1cccc(F)c1C(=O)Nc2ccc(Sc3ccccc3Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O15 compound treatment 0.364 0.00834 0.43 0.365 0.00942 0.57 0.7038 0.99 1908529 Bionet1_001013 NC(=O)NOCC(=O)N1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O16 compound treatment 0.381 0.0253 1.3 0.376 0.0204 1.23 1.788 0.9997 1384508 Bionet1_001014 Fc1ccc(cc1)C(=O)Nc2ccc(Sc3ccccc3Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O17 compound treatment 0.361 0.00534 0.27 0.36 0.00442 0.27 0.3819 0.9999 1288104 Bionet1_001015 CN(C)c1nc(N2CCN(CC2)c3c(C)cccc3C)c(C#N)c(=O)o1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O18 compound treatment 0.362 0.00634 0.32 0.359 0.00342 0.21 0.3753 0.9762 1133579 Bionet1_001016 Fc1ccc(cc1)C(=O)Nc2ccc(cc2)S(=O)(=O)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O19 compound treatment 0.357 0.00134 0.07 0.355 -5.81E-4 -0.04 0.0238 0.3085 1908530 Bionet1_001017 Clc1ccc(cc1)S(=O)CCCCS(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O20 compound treatment 0.362 0.00634 0.32 0.359 0.00342 0.21 0.3753 0.9762 1908531 Bionet1_001018 Clc1ccccc1Sc2ccc(NC(=O)C(Cl)(Cl)Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O21 compound treatment 0.372 0.0163 0.84 0.369 0.0134 0.81 1.1638 0.9999 1908532 Bionet1_001019 CCNc1nc(Sc2ccc(Br)cc2)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O22 compound treatment 0.365 0.00934 0.48 0.362 0.00642 0.39 0.6119 0.9946 1908533 Bionet1_001020 O=C(CCSSCCC(=O)NCc1ccccc1)NCc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O23 positive control 0.091 -0.265 -13.53 0.09 -0.266 -16.03 -20.9057 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 O24 positive control 0.096 -0.26 -13.28 0.097 -0.259 -15.61 -20.4261 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P01 mock treatment 0.363 0.00734 0.38 0.371 0.0154 0.93 0.9237 0.9203 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P02 mock treatment 0.36 0.00434 0.22 0.358 0.00242 0.15 0.2603 0.9793 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P03 compound treatment 0.355 -6.56E-4 -0.03 0.351 -0.00458 -0.28 -0.2193 -0.7871 1551657 Bionet1_001021 Cc1nc(nn1c2ccc(F)cc2)C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P04 compound treatment 0.361 0.00534 0.27 0.353 -0.00258 -0.16 0.083 0.264 1466673 Bionet1_001022 CS(=O)(=O)c1cnn(c1c2ccc(Cl)c(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P05 compound treatment 0.356 3.44E-4 0.02 0.355 -5.81E-4 -0.04 -0.0124 -0.3151 1478102 Bionet1_001023 Cc1nc(nn1c2ccc(Cl)cc2Cl)C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P06 compound treatment 0.358 0.00234 0.12 0.36 0.00442 0.27 0.2734 0.9348 1908534 Bionet1_001024 C/C(=N\Oc1ccc2c(cc(nc2n1)C(F)(F)F)C(F)(F)F)/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P07 compound treatment 0.336 -0.0197 -1.01 0.344 -0.0116 -0.7 -1.205 -0.9843 1712053 Bionet1_001025 Cc1nc(nn1c2ccc(Cl)cc2Cl)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P08 compound treatment 0.359 0.00334 0.17 0.363 0.00742 0.45 0.4376 0.9128 1908535 Bionet1_001026 FC(F)(F)c1cnc(N2CCc3nc(ncc3C2)c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P09 compound treatment 0.378 0.0223 1.14 0.379 0.0234 1.41 1.8076 0.9944 1300978 Bionet1_001027 Cc1nc(nn1c2ccc(Cl)cc2Cl)C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P10 compound treatment 0.357 0.00134 0.07 0.356 4.19E-4 0.03 0.0665 0.908 1908536 Bionet1_001028 Cc1nc(c(s1)C(=O)NC(=O)Nc2cccc(c2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P11 compound treatment 0.349 -0.00666 -0.34 0.354 -0.00158 -0.1 -0.3081 -0.8717 1143904 Bionet1_001029 Cc1nc(nn1c2cc(Cl)ccc2Cl)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P12 compound treatment 0.358 0.00234 0.12 0.358 0.00242 0.15 0.188 0.9952 1908537 Bionet1_001030 Cc1nc(c(s1)C(=O)NC(=O)Nc2ccc(Cl)cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P13 compound treatment 0.352 -0.00366 -0.19 0.358 0.00242 0.15 -0.0289 -0.1219 1200195 Bionet1_001031 Cc1nc(nn1c2cc(Cl)ccc2Cl)C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P14 compound treatment 0.365 0.00934 0.48 0.364 0.00842 0.51 0.6972 0.9995 1908538 Bionet1_001032 CN(NC(=O)Nc1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P15 compound treatment 0.35 -0.00566 -0.29 0.348 -0.00758 -0.46 -0.5281 -0.9755 1908539 Bionet1_001033 FC(F)(F)c1cccc(c1)S(=O)(=O)c2snnc2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P16 compound treatment 0.362 0.00634 0.32 0.359 0.00342 0.21 0.3753 0.9762 1908540 Bionet1_001034 CN(C)/C=N/C(=O)C(c1ccccc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P17 compound treatment 0.358 0.00234 0.12 0.358 0.00242 0.15 0.188 0.9952 1908541 Bionet1_001035 Brc1ccc(cc1)S(=O)(=O)c2snnc2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P18 compound treatment 0.351 -0.00466 -0.24 0.351 -0.00458 -0.28 -0.3639 -0.9972 1908542 Bionet1_001036 O/N=C/NC(=O)C(c1ccccc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P19 compound treatment 0.358 0.00234 0.12 0.359 0.00342 0.21 0.2307 0.9665 1908543 Bionet1_001037 Clc1ccc(cc1Cl)S(=O)(=O)c2snnc2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P20 compound treatment 0.36 0.00434 0.22 0.364 0.00842 0.51 0.5164 0.9311 1908544 Bionet1_001038 O/N=C/NC(=O)C(c1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P21 compound treatment 0.359 0.00334 0.17 0.36 0.00442 0.27 0.3095 0.9769 1256303 Bionet1_001039 Cc1nc(nn1c2cc(Cl)ccc2Cl)C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P22 compound treatment 0.357 0.00134 0.07 0.359 0.00342 0.21 0.1945 0.8942 1908545 Bionet1_001040 Clc1cccc(NN/C(=N\C(=O)Nc2ccccc2)/Cn3cncn3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P23 positive control 0.092 -0.264 -13.48 0.092 -0.264 -15.91 -20.7842 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.570 P24 positive control 0.097 -0.259 -13.23 0.095 -0.261 -15.73 -20.4754 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A01 mock treatment 0.33 -0.0241 -1.23 0.328 -0.0313 -1.89 -2.208 -0.9787 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A02 mock treatment 0.324 -0.0301 -1.54 0.338 -0.0213 -1.29 -1.998 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A03 compound treatment 0.324 -0.0301 -1.54 0.329 -0.0303 -1.83 -2.3822 -0.9964 1908546 Bionet1_001041 Clc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A04 compound treatment 0.331 -0.0231 -1.18 0.333 -0.0263 -1.59 -1.9584 -0.9895 1633996 Bionet1_001042 COc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A05 compound treatment 0.337 -0.0171 -0.88 0.341 -0.0183 -1.1 -1.3999 -0.9934 1146805 Bionet1_001043 Clc1cccc(Cl)c1Cn2c(ccc(C#N)c2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A06 compound treatment 0.341 -0.0131 -0.67 0.346 -0.0133 -0.8 -1.0419 -0.9961 1908547 Bionet1_001044 COc1ccc(cc1)c2ccc(C#N)c(OC(=O)c3c(Cl)cccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A07 compound treatment 0.338 -0.0161 -0.82 0.349 -0.0103 -0.62 -1.0223 -0.9903 1908548 Bionet1_001045 FC(F)(F)c1cccc(Cn2c(ccc(C#N)c2=O)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A08 compound treatment 0.336 -0.0181 -0.93 0.348 -0.0113 -0.68 -1.1373 -0.9886 1438828 Bionet1_001046 OC(CSc1ccc(F)cc1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A09 compound treatment 0.323 -0.0311 -1.59 0.328 -0.0313 -1.89 -2.461 -0.9964 1324721 Bionet1_001047 Brc1ccc(cc1)N2C(=O)CS(=O)(=O)C(C2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A10 compound treatment 0.325 -0.0291 -1.49 0.339 -0.0203 -1.22 -1.9192 -0.9953 1908549 Bionet1_001048 COc1cccc(c1)c2ccc(C#N)c(OC(=O)c3c(Cl)cccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A11 compound treatment 0.33 -0.0241 -1.23 0.334 -0.0253 -1.53 -1.9518 -0.9944 1241380 Bionet1_001049 Clc1ccc(cc1)N2C(=O)CS(=O)(=O)C(C2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A12 compound treatment 0.332 -0.0221 -1.13 0.321 -0.0383 -2.31 -2.4344 -0.946 1908550 Bionet1_001050 COc1cccc(c1)c2ccc(C#N)c(OC(=O)c3ccc(Cl)cc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A13 compound treatment 0.323 -0.0311 -1.59 0.327 -0.0323 -1.95 -2.5037 -0.9949 1210179 Bionet1_001051 Clc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A14 compound treatment 0.32 -0.0341 -1.74 0.33 -0.0293 -1.77 -2.4841 -1.0 1908551 Bionet1_001052 COc1cccc(c1)c2ccc(C#N)c(OC(=O)c3cccc(c3)C(F)(F)F)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A15 compound treatment 0.323 -0.0311 -1.59 0.332 -0.0273 -1.65 -2.2903 -0.9999 1908552 Bionet1_001053 FC(F)(F)c1ccc(Cn2c(ccc(C#N)c2=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A16 compound treatment 0.323 -0.0311 -1.59 0.329 -0.0303 -1.83 -2.4184 -0.9976 1908553 Bionet1_001054 COc1cccc(c1)c2ccc(C#N)c(OC(=O)c3ccc(F)cc3F)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A17 compound treatment 0.324 -0.0301 -1.54 0.335 -0.0243 -1.47 -2.1261 -0.9997 1250294 Bionet1_001055 Clc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A18 compound treatment 0.326 -0.0281 -1.44 0.331 -0.0283 -1.71 -2.2245 -0.9963 1908554 Bionet1_001056 FC(F)(F)c1cccc(c1)c2ccc(C#N)c(Oc3cccc(Cl)c3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A19 compound treatment 0.326 -0.0281 -1.44 0.334 -0.0253 -1.53 -2.0965 -0.9996 1573085 Bionet1_001057 COc1ccc(Cn2c(ccc(C#N)c2=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A20 compound treatment 0.325 -0.0291 -1.49 0.332 -0.0273 -1.65 -2.218 -0.9987 1455913 Bionet1_001058 Clc1ccc(NC(=O)C2CCCN2S(=O)(=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A21 compound treatment 0.328 -0.0261 -1.34 0.329 -0.0303 -1.83 -2.2376 -0.9881 1333412 Bionet1_001059 Clc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A22 compound treatment 0.324 -0.0301 -1.54 0.332 -0.0273 -1.65 -2.2541 -0.9994 1588053 Bionet1_001060 Clc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A23 positive control 0.087 -0.267 -13.66 0.091 -0.268 -16.2 -21.1107 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 A24 positive control 0.089 -0.265 -13.56 0.092 -0.267 -16.14 -20.9957 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B01 mock treatment 0.364 0.00987 0.5 0.358 -0.00129 -0.08 0.302 0.591 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B02 mock treatment 0.362 0.00787 0.4 0.366 0.00671 0.41 0.5711 1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B03 compound treatment 0.365 0.0109 0.56 0.368 0.00871 0.53 0.765 0.9996 1638075 Bionet1_001061 Fc1cc(F)c(NC(=O)c2cccn(Cc3ccccc3)c2=O)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B04 compound treatment 0.372 0.0179 0.91 0.372 0.0127 0.77 1.1888 0.9962 1908555 Bionet1_001062 Clc1cccc(n1)N2N=C/C(=C/Nc3ccc(Oc4ccccc4)cc3)/C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B05 compound treatment 0.368 0.0139 0.71 0.377 0.0177 1.07 1.2576 0.9802 1908556 Bionet1_001063 CCOC(=O)NC(=O)C(/C=N\OCCOc1cccc(c1)C(F)(F)F)C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B06 compound treatment 0.365 0.0109 0.56 0.368 0.00871 0.53 0.765 0.9996 1908557 Bionet1_001064 CO/N=C/NC(=O)C(c1ccccc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B07 compound treatment 0.376 0.0219 1.12 0.371 0.0117 0.71 1.2908 0.9755 1908558 Bionet1_001065 Nc1c(sc2ncc(C#N)cc12)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B08 compound treatment 0.355 8.75E-4 0.04 0.356 -0.00329 -0.2 -0.1088 -0.5344 1908559 Bionet1_001066 Clc1ccc(NC(=O)/N=C(/Cn2cncn2)\NNc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B09 compound treatment 0.369 0.0149 0.76 0.37 0.0107 0.65 0.995 0.9967 1908560 Bionet1_001067 Clc1ccc(CSc2snnc2c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B10 compound treatment 0.37 0.0159 0.81 0.352 -0.00729 -0.44 0.2628 0.2846 1908561 Bionet1_001068 Sc1nnc(CNS(=O)(=O)c2ccc(Br)cc2)n1CC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B11 compound treatment 0.323 -0.0311 -1.59 0.356 -0.00329 -0.2 -1.2658 -0.7892 1908562 Bionet1_001069 Clc1ccc(CS(=O)(=O)c2snnc2c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B12 compound treatment 0.354 -1.25E-4 -0.01 0.354 -0.00529 -0.32 -0.2303 -0.7211 1908563 Bionet1_001070 CCn1c(S)nnc1CNS(=O)(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B13 compound treatment 0.349 -0.00513 -0.26 0.366 0.00671 0.41 0.1011 0.2096 1908564 Bionet1_001071 FC(F)(F)c1cccc(CS(=O)(=O)c2snnc2c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B14 compound treatment 0.354 -1.25E-4 -0.01 0.37 0.0107 0.65 0.4526 0.7001 1908565 Bionet1_001072 CCn1c(CNS(=O)(=O)c2ccc(Br)cc2)nnc1SC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B15 compound treatment 0.357 0.00287 0.15 0.363 0.00371 0.22 0.2623 0.9792 1908566 Bionet1_001073 Clc1ccccc1CS(=O)(=O)c2snnc2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B16 compound treatment 0.369 0.0149 0.76 0.38 0.0207 1.25 1.4219 0.9716 1908567 Bionet1_001074 FC(F)(F)c1nc(/C=C/Nc2cccc(c2)C(F)(F)F)sc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B17 compound treatment 0.355 8.75E-4 0.04 0.369 0.00971 0.59 0.4461 0.7589 1197982 Bionet1_001075 Cc1nc(nn1c2cc(Cl)ccc2Cl)C(=O)Nc3ccc(F)c(F)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B18 compound treatment 0.366 0.0119 0.61 0.367 0.00771 0.47 0.7585 0.9914 1908568 Bionet1_001076 CN1C(=NS(=O)(=O)c2ccccc12)Nc3nc(C)cc(C)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B19 compound treatment 0.36 0.00587 0.3 0.363 0.00371 0.22 0.3708 0.9895 1616006 Bionet1_001077 Cc1nc(nn1c2cc(Cl)ccc2Cl)C(=O)Nc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B20 compound treatment 0.366 0.0119 0.61 0.37 0.0107 0.65 0.8865 0.9995 1908569 Bionet1_001078 FC(F)(F)c1cnc2cc(sc2c1)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B21 compound treatment 0.363 0.00887 0.45 0.366 0.00671 0.41 0.6073 0.9984 1908570 Bionet1_001079 Fc1ccc(Sc2snnc2c3ccc(Cl)cc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B22 compound treatment 0.359 0.00487 0.25 0.36 7.1E-4 0.04 0.2066 0.8167 1323845 Bionet1_001080 Cc1cc(C)c(C#N)c(OC(=O)c2c(Cl)cc(Cl)cc2Cl)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B23 positive control 0.086 -0.268 -13.71 0.092 -0.267 -16.14 -21.1041 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 B24 positive control 0.09 -0.264 -13.51 0.093 -0.266 -16.08 -20.9168 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C01 mock treatment 0.357 0.00287 0.15 0.353 -0.00629 -0.38 -0.1646 -0.4041 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C02 mock treatment 0.366 0.0119 0.61 0.36 7.1E-4 0.04 0.4596 0.7551 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C03 compound treatment 0.352 -0.00213 -0.11 0.364 0.00471 0.28 0.1242 0.4081 1723417 Bionet1_001081 Clc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C04 compound treatment 0.362 0.00787 0.4 0.366 0.00671 0.41 0.5711 1.0 1223342 Bionet1_001082 Fc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)Nc3ccc(F)c(F)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C05 compound treatment 0.359 0.00487 0.25 0.366 0.00671 0.41 0.4627 0.9728 1298207 Bionet1_001083 Clc1ccc(cc1)C2SCC(=O)N(C2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C06 compound treatment 0.354 -1.25E-4 -0.01 0.362 0.00271 0.16 0.1111 0.679 1658525 Bionet1_001084 Fc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C07 compound treatment 0.356 0.00187 0.1 0.359 -2.9E-4 -0.02 0.0554 0.5684 1908571 Bionet1_001085 Clc1ccc(cc1)c2nn(cc2n3cncn3)S(=O)(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C08 compound treatment 0.355 8.75E-4 0.04 0.357 -0.00229 -0.14 -0.0661 -0.4551 1908572 Bionet1_001086 OCc1cnc(S)n1CCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C09 compound treatment 0.466 0.112 5.72 0.451 0.0917 5.54 7.9598 0.9999 1908573 Bionet1_001087 CSc1cccc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C10 compound treatment 0.353 -0.00113 -0.06 0.359 -2.9E-4 -0.02 -0.0531 -0.8825 1132556 Bionet1_001088 Cn1c(CS(=O)(=O)c2ccccc2)cnc1SCc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C11 compound treatment 0.487 0.133 6.79 0.494 0.135 8.13 10.5546 0.996 1908574 Bionet1_001089 COc1ccccc1N/C=C/c2onc(c2C#N)c3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C12 compound treatment 0.382 0.0279 1.43 0.38 0.0207 1.25 1.8919 0.9979 1908575 Bionet1_001090 CNC(=S)NNC(=O)c1sccc1OCc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C13 compound treatment 0.345 -0.00913 -0.47 0.347 -0.0123 -0.74 -0.8546 -0.975 1908576 Bionet1_001091 Cc1snc(SCc2n[nH]c(COc3ccc(F)cc3)n2)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C14 compound treatment 0.341 -0.0131 -0.67 0.34 -0.0193 -1.16 -1.298 -0.9657 1908577 Bionet1_001092 Cn1c(S)nnc1c2sccc2OCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C15 compound treatment 0.355 8.75E-4 0.04 0.356 -0.00329 -0.2 -0.1088 -0.5344 1908578 Bionet1_001093 Cc1noc(/C=C/c2ccc(o2)c3ccc(Cl)cc3Cl)c1[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C16 compound treatment 0.353 -0.00113 -0.06 0.361 0.00171 0.1 0.0323 0.2734 1908579 Bionet1_001094 CSc1nnc(c2sccc2OCc3ccc(Cl)cc3Cl)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C17 compound treatment 0.354 -1.25E-4 -0.01 0.36 7.1E-4 0.04 0.0258 0.595 1362191 Bionet1_001095 Clc1ccc(c2ccc(Cc3n[nH]c(=O)c4ccccc34)o2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C18 compound treatment 0.366 0.0119 0.61 0.328 -0.0313 -1.89 -0.9063 -0.4568 1908580 Bionet1_001096 CNC(=S)NNC(=O)c1sccc1OCc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C19 compound treatment 0.362 0.00787 0.4 0.36 7.1E-4 0.04 0.315 0.7779 1908581 Bionet1_001097 CO/N=C\NC(=O)c1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C20 compound treatment 0.352 -0.00213 -0.11 0.35 -0.00929 -0.56 -0.4734 -0.8287 1908582 Bionet1_001098 Cn1c(S)nnc1c2sccc2OCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C21 compound treatment 0.363 0.00887 0.45 0.358 -0.00129 -0.08 0.2658 0.5773 1908583 Bionet1_001099 CCOC(=O)C(Cc1ccc(cc1)C(=O)OC)(NC(=O)C)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C22 compound treatment 0.36 0.00587 0.3 0.367 0.00771 0.47 0.5415 0.9776 1908584 Bionet1_001100 CSc1nnc(c2sccc2OCc3cccc(c3)C(F)(F)F)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C23 positive control 0.084 -0.27 -13.81 0.092 -0.267 -16.14 -21.1764 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 C24 positive control 0.091 -0.263 -13.45 0.099 -0.26 -15.71 -20.6245 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D01 mock treatment 0.345 -0.00913 -0.47 0.351 -0.00829 -0.5 -0.6838 -0.9994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D02 mock treatment 0.351 -0.00313 -0.16 0.357 -0.00229 -0.14 -0.2108 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D03 compound treatment 0.364 0.00987 0.5 0.365 0.00571 0.34 0.6008 0.9827 1908585 Bionet1_001101 Clc1ccc(c2nnsc2SCc3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D04 compound treatment 0.347 -0.00713 -0.36 0.358 -0.00129 -0.08 -0.3127 -0.8393 1908586 Bionet1_001102 CN(C)/C=C(/c1ncc(cc1Cl)C(F)(F)F)\S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D05 compound treatment 0.368 0.0139 0.71 0.369 0.00971 0.59 0.9161 0.9955 1908587 Bionet1_001103 Clc1ccc(cc1)c2nnsc2Sc3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D06 compound treatment 0.348 -0.00613 -0.31 0.356 -0.00329 -0.2 -0.3619 -0.9759 1908588 Bionet1_001104 CO/N=C/C(c1ncc(cc1Cl)C(F)(F)F)S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D07 compound treatment 0.344 -0.0101 -0.52 0.356 -0.00329 -0.2 -0.5065 -0.9135 1525588 Bionet1_001105 Cc1nc(nn1c2cc(Cl)cc(Cl)c2)C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D08 compound treatment 0.378 0.0239 1.22 0.388 0.0287 1.73 2.0888 0.9853 1347380 Bionet1_001106 COc1ccc(NC(=O)CS(=O)(=O)Cc2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D09 compound treatment 0.345 -0.00913 -0.47 0.351 -0.00829 -0.5 -0.6838 -0.9994 1381444 Bionet1_001107 Cc1nc(nn1c2cc(Cl)cc(Cl)c2)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D10 compound treatment 0.346 -0.00813 -0.42 0.348 -0.0113 -0.68 -0.7757 -0.9718 1908589 Bionet1_001108 FC(F)(F)c1cccc(NC(=O)CS(=O)Cc2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D11 compound treatment 0.372 0.0179 0.91 0.389 0.0297 1.79 1.9145 0.9511 1908590 Bionet1_001109 Clc1ccc(c2nnsc2Sc3ccccc3Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D12 compound treatment 0.355 8.75E-4 0.04 0.355 -0.00429 -0.26 -0.1515 -0.5764 1908591 Bionet1_001110 FC(F)(F)c1cccc(NC(=O)CS(=O)c2cccc(Cl)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D13 compound treatment 0.356 0.00187 0.1 0.373 0.0137 0.83 0.653 0.7838 1238011 Bionet1_001111 Cc1nc(nn1c2cc(Cl)cc(Cl)c2)C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D14 compound treatment 0.36 0.00587 0.3 0.368 0.00871 0.53 0.5842 0.9647 1908592 Bionet1_001112 FC(F)(F)c1cnc(/C=C(\C#N)/C(=O)Nc2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D15 compound treatment 0.352 -0.00213 -0.11 0.355 -0.00429 -0.26 -0.26 -0.9256 1416561 Bionet1_001113 COc1ccc(NC(=O)c2nc(C)n(n2)c3cc(Cl)cc(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D16 compound treatment 0.35 -0.00413 -0.21 0.361 0.00171 0.1 -0.0762 -0.3243 1908593 Bionet1_001114 FC(F)(F)c1cccc(c1)S(=O)CC(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D17 compound treatment 0.35 -0.00413 -0.21 0.355 -0.00429 -0.26 -0.3323 -0.9948 1702956 Bionet1_001115 Cc1nc(nn1c2cc(Cl)cc(Cl)c2)C(=O)Nc3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D18 compound treatment 0.362 0.00787 0.4 0.362 0.00271 0.16 0.4004 0.9212 1908594 Bionet1_001116 FC(F)(F)c1cccc(NC(=O)CS(=O)(=O)Cc2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D19 compound treatment 0.35 -0.00413 -0.21 0.356 -0.00329 -0.2 -0.2896 -0.9996 1328682 Bionet1_001117 Cc1nc(nn1c2cc(Cl)cc(Cl)c2)C(=O)Nc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D20 compound treatment 0.352 -0.00213 -0.11 0.361 0.00171 0.1 -0.0039 -0.0257 1908595 Bionet1_001118 COc1ccc(cc1)S(=O)(=O)CC(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D21 compound treatment 0.357 0.00287 0.15 0.358 -0.00129 -0.08 0.0489 0.2937 1382939 Bionet1_001119 Cc1nc(nn1c2cc(Cl)cc(Cl)c2)C(=O)Nc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D22 compound treatment 0.355 8.75E-4 0.04 0.364 0.00471 0.28 0.2327 0.8084 1908596 Bionet1_001120 FC(F)(F)c1cccc(NC(=O)CS(=O)(=O)c2cccc(Cl)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D23 positive control 0.085 -0.269 -13.76 0.09 -0.269 -16.26 -21.2257 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 D24 positive control 0.09 -0.264 -13.51 0.095 -0.264 -15.95 -20.8314 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E01 mock treatment 0.345 -0.00913 -0.47 0.362 0.00271 0.16 -0.2143 -0.4333 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E02 mock treatment 0.365 0.0109 0.56 0.366 0.00671 0.41 0.6796 0.9879 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E03 compound treatment 0.364 0.00987 0.5 0.372 0.0127 0.77 0.8996 0.9794 1908597 Bionet1_001121 CCCNS(=O)(=O)c1cccn1c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E04 compound treatment 0.334 -0.0201 -1.03 0.353 -0.00629 -0.38 -0.9962 -0.9082 1908598 Bionet1_001122 Sc1nnc([nH]1)c2sccc2OCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E05 compound treatment 0.358 0.00387 0.2 0.368 0.00871 0.53 0.5119 0.911 1908599 Bionet1_001123 [O-][N+](=O)/C(=C\Nc1cccc(c1)C(F)(F)F)/S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E06 compound treatment 0.368 0.0139 0.71 0.38 0.0207 1.25 1.3857 0.964 1908600 Bionet1_001124 CSc1nnc([nH]1)c2sccc2OCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E07 compound treatment 0.373 0.0189 0.97 0.376 0.0167 1.01 1.3957 0.9998 1908601 Bionet1_001125 Cc1c(Cl)cccc1N/C=C(\[N+](=O)[O-])/S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E08 compound treatment 0.366 0.0119 0.61 0.371 0.0117 0.71 0.9292 0.9971 1908602 Bionet1_001126 COC(=O)CC(=NNc1ncc(cc1Cl)C(F)(F)F)CC(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E09 compound treatment 0.375 0.0209 1.07 0.377 0.0177 1.07 1.5107 1.0 1908603 Bionet1_001127 [O-][N+](=O)/C(=C\Nc1ccc(Br)cc1)/S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E10 compound treatment 0.358 0.00387 0.2 0.369 0.00971 0.59 0.5546 0.8963 1908604 Bionet1_001128 CN(c1ncc(cc1Cl)C(F)(F)F)n2cc(C#N)c3ccccc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E11 compound treatment 0.43 0.0759 3.88 0.433 0.0737 4.45 5.8898 0.9977 1908605 Bionet1_001129 [O-][N+](=O)/C(=C\Nc1ccc(Oc2ccccc2)cc1)/S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E12 compound treatment 0.352 -0.00213 -0.11 0.376 0.0167 1.01 0.6365 0.6273 1366469 Bionet1_001130 OC(CS(=O)(=O)Cc1ccccc1)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E13 compound treatment 0.348 -0.00613 -0.31 0.365 0.00571 0.34 0.0223 0.0478 1908606 Bionet1_001131 [O-][N+](=O)/C(=C\Nc1ccc(Cl)c(Cl)c1)/S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E14 compound treatment 0.352 -0.00213 -0.11 0.367 0.00771 0.47 0.2523 0.5278 1367991 Bionet1_001132 OC(CSc1ccc(Cl)cc1)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E15 compound treatment 0.387 0.0329 1.68 0.405 0.0457 2.76 3.1398 0.9718 1908607 Bionet1_001133 COC(=O)c1cccc(N/C=C(\[N+](=O)[O-])/S(=O)(=O)c2ccccc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E16 compound treatment 0.344 -0.0101 -0.52 0.355 -0.00429 -0.26 -0.5492 -0.9488 1520724 Bionet1_001134 OC(CSCc1ccccc1)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E17 compound treatment 0.355 8.75E-4 0.04 0.36 7.1E-4 0.04 0.0619 0.9998 1908608 Bionet1_001135 [O-][N+](=O)/C(=C\Nc1ccc(cc1)C(F)(F)F)/S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E18 compound treatment 0.358 0.00387 0.2 0.36 7.1E-4 0.04 0.1704 0.8406 1636688 Bionet1_001136 OC(CSCc1ccc(Cl)cc1)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E19 compound treatment 0.355 8.75E-4 0.04 0.354 -0.00529 -0.32 -0.1942 -0.6022 1908609 Bionet1_001137 CN(C)S(=O)(=O)c1cccn1c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E20 compound treatment 0.389 0.0349 1.78 0.389 0.0297 1.79 2.5292 1.0 1179101 Bionet1_001138 Cc1cccc(SCC(O)(c2ccc(Cl)cc2)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E21 compound treatment 0.365 0.0109 0.56 0.366 0.00671 0.41 0.6796 0.9879 1908610 Bionet1_001139 CN(C)/C=N/S(=O)(=O)c1cccn1c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E22 compound treatment 0.358 0.00387 0.2 0.366 0.00671 0.41 0.4265 0.9459 1148662 Bionet1_001140 OC(CS(=O)c1ccc(Cl)cc1)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E23 positive control 0.087 -0.267 -13.66 0.088 -0.271 -16.38 -21.2387 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 E24 positive control 0.09 -0.264 -13.51 0.096 -0.263 -15.89 -20.7888 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F01 mock treatment 0.355 8.75E-4 0.04 0.364 0.00471 0.28 0.2327 0.8084 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F02 mock treatment 0.358 0.00387 0.2 0.365 0.00571 0.34 0.3838 0.9654 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F03 compound treatment 0.376 0.0219 1.12 0.382 0.0227 1.37 1.7603 0.9949 1908611 Bionet1_001141 Fc1ccc(cc1)c2nnsc2Sc3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F04 compound treatment 0.386 0.0319 1.63 0.387 0.0277 1.67 2.3353 0.9999 1908612 Bionet1_001142 Clc1ccc(cc1Cl)S(=O)(=O)CC(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F05 compound treatment 0.372 0.0179 0.91 0.404 0.0447 2.7 2.5548 0.8965 1908613 Bionet1_001143 Clc1ccc(CSc2snnc2c3ccc(Cl)cc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F06 compound treatment 0.363 0.00887 0.45 0.378 0.0187 1.13 1.1195 0.9197 1908614 Bionet1_001144 Clc1ccccc1CS(=O)(=O)CC(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F07 compound treatment 0.41 0.0559 2.86 0.42 0.0607 3.66 4.6117 0.9924 1908615 Bionet1_001145 [O-][N+](=O)c1ccc(NN2C3CCC2c4c(O3)ccc5ccccc45)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F08 compound treatment 0.358 0.00387 0.2 0.373 0.0137 0.83 0.7253 0.8523 1908616 Bionet1_001146 FC(F)(F)c1cccc(c1)S(=O)(=O)CC(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F09 compound treatment 0.363 0.00887 0.45 0.359 -2.9E-4 -0.02 0.3085 0.6793 1908617 Bionet1_001147 N/C(=N/OC(=O)Nc1ccccc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F10 compound treatment 0.351 -0.00313 -0.16 0.363 0.00371 0.22 0.0454 0.1649 1908618 Bionet1_001148 FC(F)(F)c1cccc(c1)c2nnnn2c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F11 compound treatment 0.363 0.00887 0.45 0.372 0.0127 0.77 0.8634 0.9686 1908619 Bionet1_001149 N/C(=N/OC(=O)Nc1ccc(Cl)cc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F12 compound treatment 0.358 0.00387 0.2 0.379 0.0197 1.19 0.9814 0.8137 1908620 Bionet1_001150 [O-][N+](=O)c1ccc(cc1)N2CCC(CC2)OC(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F13 compound treatment 0.353 -0.00113 -0.06 0.356 -0.00329 -0.2 -0.1811 -0.8759 1908621 Bionet1_001151 FC(F)(F)c1cnc(c(Cl)c1)n2ccc(=O)n(CCc3ccccc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F14 compound treatment 0.377 0.0229 1.17 0.384 0.0247 1.49 1.8818 0.9928 1908622 Bionet1_001152 COc1ccc(cc1)C(=O)OC2CCN(CC2)c3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F15 compound treatment 0.362 0.00787 0.4 0.365 0.00571 0.34 0.5285 0.997 1908623 Bionet1_001153 Cc1nc(ncc1C(=O)Nc2ncc(cc2Cl)C(F)(F)F)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F16 compound treatment 0.446 0.0919 4.7 0.452 0.0927 5.6 7.2793 0.9962 1908624 Bionet1_001154 Cc1ccc(cc1)C(=O)ON=C2CCN(CC2)c3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F17 compound treatment 0.377 0.0229 1.17 0.375 0.0157 0.95 1.4977 0.9946 1908625 Bionet1_001155 Cc1nn(cc1C(=O)Nc2ncc(cc2Cl)C(F)(F)F)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F18 compound treatment 0.405 0.0509 2.6 0.402 0.0427 2.58 3.6626 1.0 1908626 Bionet1_001156 COc1ccc(cc1)C(=O)ON=C2CCN(CC2)c3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F19 compound treatment 0.367 0.0129 0.66 0.399 0.0397 2.4 2.1606 0.8691 1908627 Bionet1_001157 FC(F)(F)c1cccc(c1)C(=O)Nc2ccc(CSc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F20 compound treatment 0.366 0.0119 0.61 0.37 0.0107 0.65 0.8865 0.9995 1266791 Bionet1_001158 CC(C)N(C(C)C)C(=O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F21 compound treatment 0.367 0.0129 0.66 0.369 0.00971 0.59 0.88 0.9983 1908628 Bionet1_001159 Clc1ccc(cc1)C(=O)Nc2ccc(CSc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F22 compound treatment 0.358 0.00387 0.2 0.365 0.00571 0.34 0.3838 0.9654 1583340 Bionet1_001160 Brc1ccc(cc1)N2C(=O)CSC(C2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F23 positive control 0.087 -0.267 -13.66 0.089 -0.27 -16.32 -21.196 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 F24 positive control 0.096 -0.258 -13.2 0.093 -0.266 -16.08 -20.6999 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G01 mock treatment 0.345 -0.00913 -0.47 0.355 -0.00429 -0.26 -0.5131 -0.9614 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G02 mock treatment 0.354 -1.25E-4 -0.01 0.356 -0.00329 -0.2 -0.145 -0.7295 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G03 compound treatment 0.348 -0.00613 -0.31 0.354 -0.00529 -0.32 -0.4473 -1.0 1908629 Bionet1_001161 FC(F)(F)c1cnc(c(Cl)c1)n2cccc2S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G04 compound treatment 0.351 -0.00313 -0.16 0.355 -0.00429 -0.26 -0.2961 -0.9731 1908630 Bionet1_001162 CC(=O)c1ccccc1NS(=O)(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G05 compound treatment 0.356 0.00187 0.1 0.358 -0.00129 -0.08 0.0127 0.1029 1908631 Bionet1_001163 FC(F)(F)c1cnc(Sc2ccccc2n3cccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G06 compound treatment 0.354 -1.25E-4 -0.01 0.376 0.0167 1.01 0.7088 0.7026 1506840 Bionet1_001164 OC(CSc1ccc(Cl)c(Cl)c1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G07 compound treatment 0.356 0.00187 0.1 0.365 0.00571 0.34 0.3115 0.8707 1908632 Bionet1_001165 CCC(=O)Nc1ccccc1Sc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G08 compound treatment 0.367 0.0129 0.66 0.387 0.0277 1.67 1.6483 0.9169 1249374 Bionet1_001166 OC(CS(=O)c1ccc(Cl)c(Cl)c1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G09 compound treatment 0.353 -0.00113 -0.06 0.356 -0.00329 -0.2 -0.1811 -0.8759 1908633 Bionet1_001167 FC(F)(F)c1cnc(Sc2ccccc2NC(=O)CCl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G10 compound treatment 0.343 -0.0111 -0.57 0.365 0.00571 0.34 -0.1585 -0.2383 1908634 Bionet1_001168 [O-][N+](=O)c1cc(F)ccc1Oc2ccsc2C(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G11 compound treatment 0.36 0.00587 0.3 0.363 0.00371 0.22 0.3708 0.9895 1908635 Bionet1_001169 FC(F)(F)c1cnc(c2ncc3c(Cl)cc(cn23)C(F)(F)F)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G12 compound treatment 0.351 -0.00313 -0.16 0.37 0.0107 0.65 0.3442 0.5168 1908636 Bionet1_001170 CCC(C)(C)NC(=O)c1sccc1Oc2ccc(F)cc2[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G13 compound treatment 0.352 -0.00213 -0.11 0.357 -0.00229 -0.14 -0.1746 -0.9929 1908637 Bionet1_001171 OS(=O)(=O)c1ccc(Cc2ncc(cc2Cl)C(F)(F)F)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G14 compound treatment 0.38 0.0259 1.32 0.387 0.0277 1.67 2.1184 0.9933 1908638 Bionet1_001172 [O-][N+](=O)c1cc(F)ccc1Oc2ccsc2C(=O)Nc3ccc(F)c(F)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G15 compound treatment 0.358 0.00387 0.2 0.354 -0.00529 -0.32 -0.0857 -0.2281 1908639 Bionet1_001173 NS(=O)(=O)c1ccc(Cc2ncc(cc2Cl)C(F)(F)F)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G16 compound treatment 0.357 0.00287 0.15 0.355 -0.00429 -0.26 -0.0792 -0.2659 1908640 Bionet1_001174 CC(C)(NC(=O)c1sccc1Oc2ccc([N+](=O)[O-])c(c2)C(F)(F)F)C#C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G17 compound treatment 0.352 -0.00213 -0.11 0.353 -0.00629 -0.38 -0.3453 -0.8743 1376726 Bionet1_001175 OC(CS(=O)(=O)c1ccc(Cl)cc1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G18 compound treatment 0.349 -0.00513 -0.26 0.353 -0.00629 -0.38 -0.4538 -0.9836 1682048 Bionet1_001176 OC(CNCc1cccc(Cl)c1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G19 compound treatment 0.367 0.0129 0.66 0.369 0.00971 0.59 0.88 0.9983 1908641 Bionet1_001177 OC(CSc1ccc(Br)cc1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G20 compound treatment 0.363 0.00887 0.45 0.359 -2.9E-4 -0.02 0.3085 0.6793 1280596 Bionet1_001178 OC(CNCc1ccc(Cl)cc1Cl)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G21 compound treatment 0.357 0.00287 0.15 0.364 0.00471 0.28 0.305 0.9529 1655282 Bionet1_001179 OC(CS(=O)c1ccc(Cl)cc1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G22 compound treatment 0.351 -0.00313 -0.16 0.352 -0.00729 -0.44 -0.4242 -0.906 1349629 Bionet1_001180 COc1ccccc1CNCC(O)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G23 positive control 0.087 -0.267 -13.66 0.091 -0.268 -16.2 -21.1107 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 G24 positive control 0.094 -0.26 -13.3 0.097 -0.262 -15.83 -20.6014 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H01 mock treatment 0.356 0.00187 0.1 0.371 0.0117 0.71 0.5676 0.7957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H02 mock treatment 0.364 0.00987 0.5 0.357 -0.00229 -0.14 0.2593 0.4953 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H03 compound treatment 0.395 0.0409 2.09 0.391 0.0317 1.91 2.8315 0.999 1908642 Bionet1_001181 Clc1cc(Cl)cc(c1)C(=O)Nc2ccc(CSc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H04 compound treatment 0.361 0.00687 0.35 0.372 0.0127 0.77 0.7911 0.9374 1908643 Bionet1_001182 CN(C)/C=C(/C(=O)c1ccc(Cl)cc1Cl)\S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H05 compound treatment 0.395 0.0409 2.09 0.41 0.0507 3.06 3.6425 0.9827 1908644 Bionet1_001183 Fc1ccc(C(=O)Nc2ccc(CSc3ccccc3)cc2)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H06 compound treatment 0.356 0.00187 0.1 0.367 0.00771 0.47 0.3969 0.8352 1908645 Bionet1_001184 CN(C)c1ncc(c(n1)c2ccccc2Cl)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H07 compound treatment 0.366 0.0119 0.61 0.353 -0.00629 -0.38 0.1608 0.2246 1908646 Bionet1_001185 FC(F)(F)c1ccc(cc1)C(=O)Nc2ccc(CSc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H08 compound treatment 0.358 0.00387 0.2 0.365 0.00571 0.34 0.3838 0.9654 1908647 Bionet1_001186 Fc1ccc(cc1)S(=O)(=O)CC(=O)Nc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H09 compound treatment 0.362 0.00787 0.4 0.367 0.00771 0.47 0.6138 0.9974 1908648 Bionet1_001187 Clc1ccc(SCc2ccc(NC(=O)c3ccccc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H10 compound treatment 0.357 0.00287 0.15 0.366 0.00671 0.41 0.3904 0.9059 1908649 Bionet1_001188 Clc1ccc(NC(=O)CS(=O)(=O)c2ccccc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H11 compound treatment 0.387 0.0329 1.68 0.41 0.0507 3.06 3.3533 0.9602 1908650 Bionet1_001189 Fc1cccc(F)c1C(=O)Nc2ccc(CSc3ccc(Cl)cc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H12 compound treatment 0.372 0.0179 0.91 0.372 0.0127 0.77 1.1888 0.9962 1908651 Bionet1_001190 Clc1cccc(c1)S(=O)(=O)CC(=O)Nc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H13 compound treatment 0.353 -0.00113 -0.06 0.365 0.00571 0.34 0.2031 0.5811 1908652 Bionet1_001191 NS(=O)(=O)c1ccc(CCNc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H14 compound treatment 0.37 0.0159 0.81 0.376 0.0167 1.01 1.2873 0.9942 1908653 Bionet1_001192 Clc1ccc(NC(=O)CS(=O)c2ccccc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H15 compound treatment 0.36 0.00587 0.3 0.361 0.00171 0.1 0.2854 0.8985 1908654 Bionet1_001193 CC(=O)CC(=O)N1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H16 compound treatment 0.367 0.0129 0.66 0.371 0.0117 0.71 0.9654 0.9994 1908655 Bionet1_001194 Cc1ncc(c(n1)c2ccc(Cl)cc2Cl)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H17 compound treatment 0.401 0.0469 2.4 0.406 0.0467 2.82 3.6887 0.9967 1908656 Bionet1_001195 Fc1ccc(SCc2ccc(NC(=O)c3c(F)cccc3F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H18 compound treatment 0.368 0.0139 0.71 0.369 0.00971 0.59 0.9161 0.9955 1285561 Bionet1_001196 COc1ccc(cc1)S(=O)CC(=O)Nc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H19 compound treatment 0.384 0.0299 1.53 0.393 0.0337 2.03 2.5191 0.99 1908657 Bionet1_001197 Fc1ccc(SCc2ccc(NC(=O)c3ccc(F)cc3F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H20 compound treatment 0.358 0.00387 0.2 0.373 0.0137 0.83 0.7253 0.8523 1908658 Bionet1_001198 FC(F)(F)c1cccc(c1)S(=O)CC(=O)Nc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H21 compound treatment 0.364 0.00987 0.5 0.373 0.0137 0.83 0.9423 0.9719 1908659 Bionet1_001199 Fc1ccc(SCc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H22 compound treatment 0.36 0.00587 0.3 0.374 0.0147 0.89 0.8403 0.8964 1743168 Bionet1_001200 COc1ccc(cc1)S(=O)(=O)CC(=O)Nc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H23 positive control 0.089 -0.265 -13.56 0.096 -0.263 -15.89 -20.8249 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 H24 positive control 0.094 -0.26 -13.3 0.097 -0.262 -15.83 -20.6014 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I01 mock treatment 0.35 -0.00413 -0.21 0.354 -0.00529 -0.32 -0.375 -0.9797 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I02 mock treatment 0.359 0.00487 0.25 0.357 -0.00229 -0.14 0.0785 0.2754 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I03 compound treatment 0.363 0.00887 0.45 0.361 0.00171 0.1 0.3939 0.8463 1273474 Bionet1_001201 OC(CS(=O)(=O)Cc1ccccc1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I04 compound treatment 0.34 -0.0141 -0.72 0.339 -0.0203 -1.22 -1.3768 -0.9683 1742621 Bionet1_001202 COc1ccc(CNCC(O)(c2ccccc2)c3ccccc3)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I05 compound treatment 0.356 0.00187 0.1 0.36 7.1E-4 0.04 0.0981 0.9341 1394231 Bionet1_001203 Cc1cccc(c1)S(=O)(=O)CC(O)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I06 compound treatment 0.332 -0.0221 -1.13 0.358 -0.00129 -0.08 -0.855 -0.754 1405447 Bionet1_001204 OC(CNCc1ccccc1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I07 compound treatment 0.344 -0.0101 -0.52 0.35 -0.00929 -0.56 -0.7627 -0.9992 1343725 Bionet1_001205 OC(CS(=O)(=O)c1cccc(Cl)c1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I08 compound treatment 0.335 -0.0191 -0.98 0.35 -0.00929 -0.56 -1.0881 -0.9652 1400968 Bionet1_001206 Cc1ccc(CNCC(O)(c2ccc(Cl)cc2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I09 compound treatment 0.34 -0.0141 -0.72 0.35 -0.00929 -0.56 -0.9073 -0.9922 1290011 Bionet1_001207 OC(CSCc1ccc(Cl)cc1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I10 compound treatment 0.346 -0.00813 -0.42 0.362 0.00271 0.16 -0.1781 -0.3989 1245817 Bionet1_001208 OC(CNCc1ccc(F)cc1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I11 compound treatment 0.363 0.00887 0.45 0.383 0.0237 1.43 1.333 0.8877 1471810 Bionet1_001209 OC(CSc1c(Cl)cccc1Cl)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I12 compound treatment 0.352 -0.00213 -0.11 0.363 0.00371 0.22 0.0815 0.3275 1480312 Bionet1_001210 OC(CNCc1ccccc1F)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I13 compound treatment 0.358 0.00387 0.2 0.377 0.0177 1.07 0.8961 0.8241 1245223 Bionet1_001211 OC(CS(=O)c1c(Cl)cccc1Cl)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I14 compound treatment 0.354 -1.25E-4 -0.01 0.359 -2.9E-4 -0.02 -0.0169 -0.9066 1281121 Bionet1_001212 OC(CN1CCOCC1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I15 compound treatment 0.364 0.00987 0.5 0.352 -0.00729 -0.44 0.0458 0.0684 1535297 Bionet1_001213 OC(CS(=O)Cc1ccc(Cl)cc1)(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I16 compound treatment 0.361 0.00687 0.35 0.353 -0.00629 -0.38 -0.0199 -0.0385 1908660 Bionet1_001214 CS(=O)(=O)c1ccccc1Oc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I17 compound treatment 0.363 0.00887 0.45 0.381 0.0217 1.31 1.2476 0.8995 1127818 Bionet1_001215 OC(CSCc1ccccc1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I18 compound treatment 0.363 0.00887 0.45 0.373 0.0137 0.83 0.9061 0.96 1908661 Bionet1_001216 CN(c1ncc(cc1Cl)C(F)(F)F)n2cc(C(=O)N)c3ccccc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I19 compound treatment 0.362 0.00787 0.4 0.362 0.00271 0.16 0.4004 0.9212 1908662 Bionet1_001217 Brc1ccc(Sc2nc(ccc2C#N)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I20 compound treatment 0.42 0.0659 3.37 0.421 0.0617 3.73 5.016 0.9987 1908663 Bionet1_001218 FC(F)(F)c1ccc(N/C=C/c2onc(c2C#N)c3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I21 compound treatment 0.366 0.0119 0.61 0.377 0.0177 1.07 1.1853 0.9641 1908664 Bionet1_001219 FC(F)(F)c1cccc(Sc2nc(ccc2C#N)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I22 compound treatment 0.37 0.0159 0.81 0.369 0.00971 0.59 0.9885 0.9872 1908665 Bionet1_001220 Clc1ccccc1N/C=C/c2onc(c2C#N)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I23 positive control 0.087 -0.267 -13.66 0.091 -0.268 -16.2 -21.1107 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 I24 positive control 0.092 -0.262 -13.4 0.096 -0.263 -15.89 -20.7164 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J01 mock treatment 0.351 -0.00313 -0.16 0.357 -0.00229 -0.14 -0.2108 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J02 mock treatment 0.361 0.00687 0.35 0.363 0.00371 0.22 0.4069 0.9763 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J03 compound treatment 0.362 0.00787 0.4 0.368 0.00871 0.53 0.6565 0.9913 1908666 Bionet1_001221 Cc1sc(nc1OC(=O)c2ccc(Cl)c(Cl)c2)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J04 compound treatment 0.37 0.0159 0.81 0.369 0.00971 0.59 0.9885 0.9872 1908667 Bionet1_001222 O=S(=O)(c1ccccc1)c2cnc(nc2c3ccccc3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J05 compound treatment 0.367 0.0129 0.66 0.373 0.0137 0.83 1.0507 0.9936 1908668 Bionet1_001223 Cc1sc(nc1OC(=O)c2ccc(Cl)cc2Cl)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J06 compound treatment 0.365 0.0109 0.56 0.367 0.00771 0.47 0.7223 0.9961 1908669 Bionet1_001224 O=S(=O)(c1ccccc1)c2cnc(nc2c3ccccc3)c4cccnc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J07 compound treatment 0.363 0.00887 0.45 0.361 0.00171 0.1 0.3939 0.8463 1908670 Bionet1_001225 Cc1sc(nc1OC(=O)c2cc(Cl)cc(Cl)c2)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J08 compound treatment 0.35 -0.00413 -0.21 0.373 0.0137 0.83 0.4361 0.5106 1908671 Bionet1_001226 CN(C)/C=C(/C(=O)c1ccccc1)\S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J09 compound treatment 0.386 0.0319 1.63 0.383 0.0237 1.43 2.1646 0.9979 1908672 Bionet1_001227 Cc1sc(nc1OC(=O)c2ccc(cc2)C(F)(F)F)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J10 compound treatment 0.363 0.00887 0.45 0.372 0.0127 0.77 0.8634 0.9686 1908673 Bionet1_001228 Clc1ccc(cc1)S(=O)(=O)CC(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J11 compound treatment 0.375 0.0209 1.07 0.386 0.0267 1.61 1.8949 0.9799 1908674 Bionet1_001229 Cc1sc(nc1OC(=O)c2ccc(Cl)cc2Cl)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J12 compound treatment 0.368 0.0139 0.71 0.369 0.00971 0.59 0.9161 0.9955 1908675 Bionet1_001230 CN(C)c1ncc(c(n1)c2ccccc2)S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J13 compound treatment 0.37 0.0159 0.81 0.375 0.0157 0.95 1.2446 0.997 1908676 Bionet1_001231 Cc1sc(nc1OC(=O)c2ccc(Cl)c(Cl)c2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J14 compound treatment 0.374 0.0199 1.02 0.391 0.0317 1.91 2.0722 0.9561 1532686 Bionet1_001232 Clc1ccc(CN2C(=O)CSC(C2=O)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J15 compound treatment 0.365 0.0109 0.56 0.361 0.00171 0.1 0.4662 0.8243 1908677 Bionet1_001233 Cc1sc(nc1OC(=O)c2cc(Cl)cc(Cl)c2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J16 compound treatment 0.361 0.00687 0.35 0.36 7.1E-4 0.04 0.2789 0.7875 1908678 Bionet1_001234 FC(F)(F)c1ccc(cc1)N2C(=O)CSC(C2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J17 compound treatment 0.361 0.00687 0.35 0.35 -0.00929 -0.56 -0.148 -0.2236 1908679 Bionet1_001235 Cc1sc(nc1OC(=O)c2cccc(c2)C(F)(F)F)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J18 compound treatment 0.357 0.00287 0.15 0.365 0.00571 0.34 0.3477 0.9278 1244794 Bionet1_001236 Brc1ccc(cc1)N2C(=O)CS(=O)C(C2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J19 compound treatment 0.369 0.0149 0.76 0.36 7.1E-4 0.04 0.5681 0.7458 1908680 Bionet1_001237 Cc1sc(nc1OC(=O)c2ccc(Cl)cc2Cl)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J20 compound treatment 0.362 0.00787 0.4 0.362 0.00271 0.16 0.4004 0.9212 1516221 Bionet1_001238 Clc1ccc(N2C(=O)CSC(C2=O)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J21 compound treatment 0.359 0.00487 0.25 0.362 0.00271 0.16 0.2919 0.9791 1908681 Bionet1_001239 Cc1sc(nc1OC(=O)c2cccc(c2)C(F)(F)F)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J22 compound treatment 0.366 0.0119 0.61 0.359 -2.9E-4 -0.02 0.417 0.6864 1908682 Bionet1_001240 FC(F)(F)c1cnc(NCC2CC(=NO2)C(=O)N3CCOCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J23 positive control 0.086 -0.268 -13.71 0.089 -0.27 -16.32 -21.2322 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 J24 positive control 0.098 -0.256 -13.1 0.095 -0.264 -15.95 -20.5422 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K01 mock treatment 0.348 -0.00613 -0.31 0.357 -0.00229 -0.14 -0.3192 -0.9325 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K02 mock treatment 0.353 -0.00113 -0.06 0.352 -0.00729 -0.44 -0.3519 -0.7928 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K03 compound treatment 0.35 -0.00413 -0.21 0.357 -0.00229 -0.14 -0.2469 -0.979 1254773 Bionet1_001241 Clc1ccc(CSc2nc(ccc2C#N)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K04 compound treatment 0.44 0.0859 4.39 0.407 0.0477 2.88 5.1415 0.9791 1908683 Bionet1_001242 Cc1cc(O)ccc1N/C=C/c2onc(c2C#N)c3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K05 compound treatment 0.367 0.0129 0.66 0.386 0.0267 1.61 1.6057 0.9219 1908684 Bionet1_001243 FC(F)(F)c1cccc(Oc2nc(ccc2C#N)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K06 compound treatment 0.344 -0.0101 -0.52 0.358 -0.00129 -0.08 -0.4212 -0.8044 1908685 Bionet1_001244 CC(Oc1ccc(Cl)cc1)c2ccnn2S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K07 compound treatment 0.358 0.00387 0.2 0.363 0.00371 0.22 0.2985 0.9981 1451789 Bionet1_001245 Clc1ccc(Cn2c(ccc(C#N)c2=O)c3ccc(Cl)c(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K08 compound treatment 0.35 -0.00413 -0.21 0.353 -0.00629 -0.38 -0.4177 -0.9615 1908686 Bionet1_001246 Clc1cccc(Cl)c1CO/N=C\NC(=S)Nc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K09 compound treatment 0.349 -0.00513 -0.26 0.353 -0.00629 -0.38 -0.4538 -0.9836 1725966 Bionet1_001247 Clc1ccc(cc1Cl)c2ccc(C#N)c(=O)n2Cc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K10 compound treatment 0.357 0.00287 0.15 0.37 0.0107 0.65 0.5611 0.8463 1908687 Bionet1_001248 CC(=O)c1ccccc1NS(=O)(=O)c2cc(Cl)c(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K11 compound treatment 0.383 0.0289 1.48 0.388 0.0287 1.73 2.2695 0.9968 1908688 Bionet1_001249 [O-][N+](=O)c1ccc(Oc2ccsc2C(=O)Nc3ccccc3)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K12 compound treatment 0.37 0.0159 0.81 0.36 7.1E-4 0.04 0.6043 0.7434 1446155 Bionet1_001250 CC1CN(CC(O)(c2ccc(Cl)cc2)c3ccc(Cl)cc3)CC(C)O1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K13 compound treatment 0.384 0.0299 1.53 0.393 0.0337 2.03 2.5191 0.99 1908689 Bionet1_001251 [O-][N+](=O)c1ccc(Oc2ccsc2C(=O)Nc3ccc(F)cc3)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K14 compound treatment 0.332 -0.0221 -1.13 0.351 -0.00829 -0.5 -1.1538 -0.9327 1563283 Bionet1_001252 CN1CCN(CC(O)(c2ccc(Cl)cc2)c3ccc(Cl)cc3)CC1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K15 compound treatment 0.349 -0.00513 -0.26 0.356 -0.00329 -0.2 -0.3258 -0.9907 1908690 Bionet1_001253 CN(C(=O)c1sccc1Oc2ccc(cc2F)[N+](=O)[O-])c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K16 compound treatment 0.362 0.00787 0.4 0.355 -0.00429 -0.26 0.1016 0.2122 1908691 Bionet1_001254 COc1cnc(nc1Sc2cccc(c2)C(F)(F)F)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K17 compound treatment 0.384 0.0299 1.53 0.391 0.0317 1.91 2.4337 0.9937 1908692 Bionet1_001255 [O-][N+](=O)c1ccc(Oc2ccsc2C(=O)Nc3ccccc3F)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K18 compound treatment 0.372 0.0179 0.91 0.378 0.0187 1.13 1.4449 0.9945 1908693 Bionet1_001256 Fc1ccc(NC(=O)c2cnc(nc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K19 compound treatment 0.367 0.0129 0.66 0.368 0.00871 0.53 0.8373 0.9938 1908694 Bionet1_001257 CCOC(CNC(=O)c1sccc1Oc2ccc(cc2F)[N+](=O)[O-])OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K20 compound treatment 0.376 0.0219 1.12 0.372 0.0127 0.77 1.3334 0.9831 1908695 Bionet1_001258 Clc1ccc(NC(=O)c2cnc(nc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K21 compound treatment 0.366 0.0119 0.61 0.361 0.00171 0.1 0.5023 0.8156 1908696 Bionet1_001259 [O-][N+](=O)c1cc(F)ccc1Oc2ccsc2C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K22 compound treatment 0.359 0.00487 0.25 0.365 0.00571 0.34 0.42 0.9873 1908697 Bionet1_001260 O=C(Nc1ccccc1)c2cnc(nc2c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K23 positive control 0.088 -0.266 -13.61 0.106 -0.253 -15.29 -20.4342 -0.9983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 K24 positive control 0.095 -0.259 -13.25 0.096 -0.263 -15.89 -20.608 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L01 mock treatment 0.353 -0.00113 -0.06 0.36 7.1E-4 0.04 -0.0104 -0.1447 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L02 mock treatment 0.361 0.00687 0.35 0.365 0.00571 0.34 0.4923 1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L03 compound treatment 0.363 0.00887 0.45 0.359 -2.9E-4 -0.02 0.3085 0.6793 1908698 Bionet1_001261 Cc1sc(nc1OC(=O)c2ccc(Cl)c(Cl)c2)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L04 compound treatment 0.37 0.0159 0.81 0.368 0.00871 0.53 0.9458 0.9779 1908699 Bionet1_001262 C/[N+](=C/c1c(OCc2ccc(Cl)cc2Cl)ccc3ccccc13)/[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L05 compound treatment 0.378 0.0239 1.22 0.388 0.0287 1.73 2.0888 0.9853 1908700 Bionet1_001263 Cc1sc(nc1OC(=O)c2cccc(Cl)c2Cl)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L06 compound treatment 0.363 0.00887 0.45 0.363 0.00371 0.22 0.4792 0.947 1908701 Bionet1_001264 CN(C)/C=N/C(=O)C1=NOC(CNc2ncc(cc2Cl)C(F)(F)F)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L07 compound treatment 0.354 -1.25E-4 -0.01 0.344 -0.0153 -0.92 -0.6572 -0.712 1908702 Bionet1_001265 FC(F)(F)c1cnc(NCCNC(=O)Nc2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L08 compound treatment 0.357 0.00287 0.15 0.34 -0.0193 -1.16 -0.7195 -0.613 1908703 Bionet1_001266 FC(F)(F)c1cnc(NCC2CC(=NO2)C(=O)NC3CC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L09 compound treatment 0.366 0.0119 0.61 0.36 7.1E-4 0.04 0.4596 0.7551 1908704 Bionet1_001267 CN(C)c1ccc(/C=N\CCNc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L10 compound treatment 0.366 0.0119 0.61 0.376 0.0167 1.01 1.1426 0.9705 1908705 Bionet1_001268 FC(F)(F)c1cnc(NCC2CC(=NO2)C(=O)Nc3cccnc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L11 compound treatment 0.383 0.0289 1.48 0.386 0.0267 1.61 2.1842 0.999 1908706 Bionet1_001269 FC(F)(F)c1cnc(NCCNC(=O)c2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L12 compound treatment 0.362 0.00787 0.4 0.353 -0.00629 -0.38 0.0162 0.0293 1908707 Bionet1_001270 ON/C=N/C(=O)C1=NOC(CNc2ncc(cc2Cl)C(F)(F)F)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L13 compound treatment 0.387 0.0329 1.68 0.386 0.0267 1.61 2.3288 0.9998 1908708 Bionet1_001271 Cc1nc(ncc1C(=O)Nc2ncc(cc2Cl)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L14 compound treatment 0.357 0.00287 0.15 0.366 0.00671 0.41 0.3904 0.9059 1908709 Bionet1_001272 CON/C=N/C(=O)C1=NOC(CNc2ncc(cc2Cl)C(F)(F)F)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L15 compound treatment 0.401 0.0469 2.4 0.399 0.0397 2.4 3.3899 1.0 1908710 Bionet1_001273 Cc1sc(nc1OC(=O)c2cccc(Cl)c2Cl)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L16 compound treatment 0.393 0.0389 1.99 0.398 0.0387 2.34 3.058 0.9968 1908711 Bionet1_001274 CN(C)/C=C/C(=O)C1=NOC(CNc2ncc(cc2Cl)C(F)(F)F)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L17 compound treatment 0.392 0.0379 1.94 0.392 0.0327 1.97 2.7657 1.0 1908712 Bionet1_001275 Cc1sc(nc1OC(=O)c2cccc(c2)C(F)(F)F)c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L18 compound treatment 0.362 0.00787 0.4 0.367 0.00771 0.47 0.6138 0.9974 1908713 Bionet1_001276 Nc1nccc(n1)C2=NOC(CNc3ncc(cc3Cl)C(F)(F)F)C2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L19 compound treatment 0.366 0.0119 0.61 0.373 0.0137 0.83 1.0146 0.9884 1908714 Bionet1_001277 Cc1sc(nc1OCc2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L20 compound treatment 0.363 0.00887 0.45 0.37 0.0107 0.65 0.778 0.985 1908715 Bionet1_001278 CCOC(=O)C1=NOC(CNc2ncc(cc2Cl)C(F)(F)F)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L21 compound treatment 0.364 0.00987 0.5 0.365 0.00571 0.34 0.6008 0.9827 1908716 Bionet1_001279 COC(=O)c1ccc(cc1)c2nc(OCc3ccc(Cl)cc3)c(C)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L22 compound treatment 0.361 0.00687 0.35 0.368 0.00871 0.53 0.6204 0.9808 1908717 Bionet1_001280 CS(=O)(=O)c1cnc(nc1c2ccc(Cl)c(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L23 positive control 0.087 -0.267 -13.66 0.089 -0.27 -16.32 -21.196 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 L24 positive control 0.095 -0.259 -13.25 0.097 -0.262 -15.83 -20.5653 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M01 mock treatment 0.354 -1.25E-4 -0.01 0.368 0.00871 0.53 0.3673 0.6985 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M02 mock treatment 0.358 0.00387 0.2 0.364 0.00471 0.28 0.3411 0.9844 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M03 compound treatment 0.377 0.0229 1.17 0.388 0.0287 1.73 2.0526 0.9817 1908718 Bionet1_001281 [O-][N+](=O)c1cc(F)ccc1Oc2ccsc2C(=O)Nc3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M04 compound treatment 0.356 0.00187 0.1 0.39 0.0307 1.85 1.3787 0.7427 1908719 Bionet1_001282 Fc1ccc(NC(=O)c2cnc(nc2c3ccccc3)c4ccccc4)cc1F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M05 compound treatment 0.364 0.00987 0.5 0.386 0.0267 1.61 1.4972 0.8861 1908720 Bionet1_001283 [O-][N+](=O)c1cc(F)ccc1Oc2ccsc2C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M06 compound treatment 0.377 0.0229 1.17 0.386 0.0267 1.61 1.9672 0.9876 1587015 Bionet1_001284 Clc1ccc(CNC(=O)c2cnc(nc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M07 compound treatment 0.358 0.00387 0.2 0.365 0.00571 0.34 0.3838 0.9654 1908721 Bionet1_001285 CN(C(=O)c1sccc1Oc2ccc(F)cc2[N+](=O)[O-])c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M08 compound treatment 0.367 0.0129 0.66 0.366 0.00671 0.41 0.7519 0.9728 1908722 Bionet1_001286 CC(=O)c1cc(NC(=O)c2ccc(C)cc2)c(=O)n(Cc3ccccc3)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M09 compound treatment 0.379 0.0249 1.27 0.381 0.0217 1.31 1.8261 0.9999 1908723 Bionet1_001287 [O-][N+](=O)c1cc(F)ccc1Oc2ccsc2C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M10 compound treatment 0.363 0.00887 0.45 0.37 0.0107 0.65 0.778 0.985 1908724 Bionet1_001288 CC(=O)c1cc(NC(=O)c2ccc(Cl)cc2)c(=O)n(Cc3ccco3)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M11 compound treatment 0.354 -1.25E-4 -0.01 0.358 -0.00129 -0.08 -0.0596 -0.7626 1273341 Bionet1_001289 OC1=C(C2NCCc3ccccc23)C(=O)CC(C1)c4c(F)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M12 compound treatment 0.371 0.0169 0.86 0.375 0.0157 0.95 1.2807 0.9989 1651792 Bionet1_001290 Clc1cccc(c1)C(=O)Nc2cc3C(=O)CCCc3n(Cc4ccco4)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M13 compound treatment 0.345 -0.00913 -0.47 0.357 -0.00229 -0.14 -0.4277 -0.8789 1298481 Bionet1_001291 O=C(CC1NCCc2ccccc12)Nc3ccc(Oc4ccccc4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M14 compound treatment 0.363 0.00887 0.45 0.358 -0.00129 -0.08 0.2658 0.5773 1908725 Bionet1_001292 Cn1nc(c(C(=O)Nc2cccc(c2)C(F)(F)F)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M15 compound treatment 0.355 8.75E-4 0.04 0.358 -0.00129 -0.08 -0.0234 -0.261 1187392 Bionet1_001293 Clc1ccccc1n2ncc3C(=O)N4CCc5ccccc5C4Cc32 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M16 compound treatment 0.356 0.00187 0.1 0.37 0.0107 0.65 0.525 0.8032 1908726 Bionet1_001294 Cn1nc(c(C(=O)Nc2ccc(OC(F)(F)F)cc2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M17 compound treatment 0.362 0.00787 0.4 0.362 0.00271 0.16 0.4004 0.9212 1908727 Bionet1_001295 Fc1ccc(Sc2nc(ccc2C#N)c3ccc(Cl)c(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M18 compound treatment 0.369 0.0149 0.76 0.368 0.00871 0.53 0.9096 0.9837 1908728 Bionet1_001296 COc1ccc(OC)c(NC(=O)c2c(Cl)n(C)nc2C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M19 compound treatment 0.358 0.00387 0.2 0.359 -2.9E-4 -0.02 0.1277 0.6421 1908729 Bionet1_001297 Clc1cccc(Sc2nc(ccc2C#N)c3ccc(Cl)c(Cl)c3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M20 compound treatment 0.358 0.00387 0.2 0.361 0.00171 0.1 0.2131 0.9538 1908730 Bionet1_001298 Cn1nc(c(C(=O)Nc2ccc(Cl)c(Cl)c2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M21 compound treatment 0.361 0.00687 0.35 0.363 0.00371 0.22 0.4069 0.9763 1294695 Bionet1_001299 Clc1ccc(cc1Cl)c2ccc(C#N)c(Oc3ccccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M22 compound treatment 0.372 0.0179 0.91 0.371 0.0117 0.71 1.1461 0.9919 1908731 Bionet1_001300 Cn1nc(c(C(=O)NCc2ccc(Cl)cc2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M23 positive control 0.089 -0.265 -13.56 0.093 -0.266 -16.08 -20.953 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 M24 positive control 0.095 -0.259 -13.25 0.099 -0.26 -15.71 -20.4799 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N01 mock treatment 0.356 0.00187 0.1 0.358 -0.00129 -0.08 0.0127 0.1029 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N02 mock treatment 0.352 -0.00213 -0.11 0.36 7.1E-4 0.04 -0.0465 -0.3984 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N03 compound treatment 0.357 0.00287 0.15 0.359 -2.9E-4 -0.02 0.0916 0.6184 1908732 Bionet1_001301 CCOC(=O)NCCN1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N04 compound treatment 0.372 0.0179 0.91 0.362 0.00271 0.16 0.762 0.8206 1908733 Bionet1_001302 Fc1ccc(cc1)c2ccc(C#N)c(OC(=O)c3c(Cl)cccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N05 compound treatment 0.364 0.00987 0.5 0.363 0.00371 0.22 0.5154 0.9331 1908734 Bionet1_001303 NC(=O)NCCN1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N06 compound treatment 0.383 0.0289 1.48 0.392 0.0327 1.97 2.4403 0.9897 1908735 Bionet1_001304 [O-][N+](=O)c1ccc(Oc2ccsc2C(=O)Nc3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N07 compound treatment 0.358 0.00387 0.2 0.359 -2.9E-4 -0.02 0.1277 0.6421 1908736 Bionet1_001305 FC(F)(F)c1cnc(c(Cl)c1)n2ccc(=O)n(Cc3ccccc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N08 compound treatment 0.375 0.0209 1.07 0.374 0.0147 0.89 1.3827 0.9958 1908737 Bionet1_001306 CC(=O)Nc1ccc(NC(=O)c2sccc2Oc3ccc(cc3)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N09 compound treatment 0.364 0.00987 0.5 0.372 0.0127 0.77 0.8996 0.9794 1908738 Bionet1_001307 CN(OC(=O)c1ccc(C)cc1)/C=C/C(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N10 compound treatment 0.37 0.0159 0.81 0.375 0.0157 0.95 1.2446 0.997 1908739 Bionet1_001308 [O-][N+](=O)c1ccccc1Oc2ccsc2C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N11 compound treatment 0.361 0.00687 0.35 0.353 -0.00629 -0.38 -0.0199 -0.0385 1569330 Bionet1_001309 Fc1cccc(n1)N2CCC3(CC2)OCCN3C(=O)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N12 compound treatment 0.369 0.0149 0.76 0.386 0.0267 1.61 1.678 0.9412 1908740 Bionet1_001310 COc1ccc(OC)c(NC(=O)c2sccc2Oc3ccccc3[N+](=O)[O-])c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N13 compound treatment 0.366 0.0119 0.61 0.366 0.00671 0.41 0.7158 0.9806 1610039 Bionet1_001311 O=S(=O)(C1CON(C1c2ccccc2)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N14 compound treatment 0.408 0.0539 2.75 0.409 0.0497 3.0 4.0699 0.9991 1908741 Bionet1_001312 [O-][N+](=O)c1ccccc1Oc2ccsc2C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N15 compound treatment 0.401 0.0469 2.4 0.401 0.0417 2.52 3.4753 0.9997 1908742 Bionet1_001313 FC(F)(F)c1cccc(SCc2ccc(NC(=O)c3ccccc3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N16 compound treatment 0.39 0.0359 1.83 0.393 0.0337 2.03 2.7361 0.9987 1908743 Bionet1_001314 Cc1c(Cl)cccc1NC(=O)c2sccc2Oc3ccccc3[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N17 compound treatment 0.387 0.0329 1.68 0.394 0.0347 2.1 2.6703 0.994 1908744 Bionet1_001315 FC(F)(F)c1cccc(SCc2ccc(NC(=O)c3cccs3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N18 compound treatment 0.357 0.00287 0.15 0.362 0.00271 0.16 0.2196 0.9986 1908745 Bionet1_001316 CN(C(=O)c1sccc1Oc2ccccc2[N+](=O)[O-])c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N19 compound treatment 0.384 0.0299 1.53 0.384 0.0247 1.49 2.1349 0.9999 1908746 Bionet1_001317 Cc1ccc(SCc2ccc(NC(=O)c3c(F)cccc3F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N20 compound treatment 0.375 0.0209 1.07 0.377 0.0177 1.07 1.5107 1.0 1229369 Bionet1_001318 Clc1ccc(cc1)C2SCC(=O)N(C2=O)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N21 compound treatment 0.358 0.00387 0.2 0.367 0.00771 0.47 0.4692 0.9276 1287997 Bionet1_001319 CCOC(=O)CC1N(CCNC1=O)S(=O)(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N22 compound treatment 0.366 0.0119 0.61 0.366 0.00671 0.41 0.7158 0.9806 1540177 Bionet1_001320 Clc1ccc(cc1)C2C(=O)N(C(=O)CS2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N23 positive control 0.09 -0.264 -13.51 0.091 -0.268 -16.2 -21.0022 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 N24 positive control 0.093 -0.261 -13.35 0.097 -0.262 -15.83 -20.6376 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O01 mock treatment 0.359 0.00487 0.25 0.362 0.00271 0.16 0.2919 0.9791 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O02 mock treatment 0.358 0.00387 0.2 0.36 7.1E-4 0.04 0.1704 0.8406 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O03 compound treatment 0.354 -1.25E-4 -0.01 0.357 -0.00229 -0.14 -0.1023 -0.739 1908747 Bionet1_001321 Fc1ccc(Oc2nc(ccc2C#N)c3ccc(Cl)c(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O04 compound treatment 0.374 0.0199 1.02 0.371 0.0117 0.71 1.2185 0.9843 1640810 Bionet1_001322 O=C(N1CCSCC1)c2cnc(nc2c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O05 compound treatment 0.39 0.0359 1.83 0.398 0.0387 2.34 2.9495 0.9928 1908748 Bionet1_001323 FC(F)(F)c1cccc(c1)c2ccc(C#N)c(=O)n2Cc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O06 compound treatment 0.371 0.0169 0.86 0.381 0.0217 1.31 1.5369 0.9794 1908749 Bionet1_001324 [O-][N+](=O)c1ccc(cc1)N2CCC(=NNc3nc4ccccc4[nH]c3=O)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O07 compound treatment 0.367 0.0129 0.66 0.364 0.00471 0.28 0.6666 0.9295 1908750 Bionet1_001325 [O-][N+](=O)c1ccc(Cn2c(ccc(C#N)c2=O)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O08 compound treatment 0.404 0.0499 2.55 0.423 0.0637 3.85 4.5228 0.9801 1908751 Bionet1_001326 [O-][N+](=O)c1cccnc1N2CCC(=NNc3nc4ccccc4[nH]c3=O)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O09 compound treatment 0.36 0.00587 0.3 0.362 0.00271 0.16 0.3281 0.9592 1288621 Bionet1_001327 Fc1ccc(cc1)c2ccc(C#N)c(Oc3ccc(Cl)c(Cl)c3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O10 compound treatment 0.353 -0.00113 -0.06 0.361 0.00171 0.1 0.0323 0.2734 1908752 Bionet1_001328 Clc1ccc(CO/N=C/2\CCSC3=C2c4ccccc4C3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O11 compound treatment 0.361 0.00687 0.35 0.362 0.00271 0.16 0.3642 0.9394 1307904 Bionet1_001329 Fc1ccc(cc1)c2ccc(C#N)c(Oc3cccc(Cl)c3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O12 compound treatment 0.378 0.0239 1.22 0.376 0.0167 1.01 1.5765 0.9955 1908753 Bionet1_001330 [O-][N+](=O)c1ccc(cc1)N2CCC(=NOCc3ccc(Cl)cc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O13 compound treatment 0.369 0.0149 0.76 0.365 0.00571 0.34 0.7815 0.9359 1908754 Bionet1_001331 Fc1ccc(Oc2nc(ccc2C#N)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O14 compound treatment 0.362 0.00787 0.4 0.359 -2.9E-4 -0.02 0.2723 0.6757 1908755 Bionet1_001332 CCOC(=O)c1cc(C(=O)OCC)c(NNC(=O)c2ccncc2)nc1N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O15 compound treatment 0.367 0.0129 0.66 0.377 0.0177 1.07 1.2215 0.9729 1908756 Bionet1_001333 COc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O16 compound treatment 0.362 0.00787 0.4 0.361 0.00171 0.1 0.3577 0.8605 1908757 Bionet1_001334 CCOC(=O)c1cc(C(=O)OCC)c2nnc(c3ccncc3)n2c1N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O17 compound treatment 0.372 0.0179 0.91 0.371 0.0117 0.71 1.1461 0.9919 1276453 Bionet1_001335 COc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O18 compound treatment 0.358 0.00387 0.2 0.366 0.00671 0.41 0.4265 0.9459 1319091 Bionet1_001336 CCOC(=O)c1cc(C(=O)OCC)c2nnc(c3ccc(Cl)cc3)n2c1N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O19 compound treatment 0.363 0.00887 0.45 0.358 -0.00129 -0.08 0.2658 0.5773 1908758 Bionet1_001337 COc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O20 compound treatment 0.363 0.00887 0.45 0.365 0.00571 0.34 0.5646 0.9908 1908759 Bionet1_001338 Cc1[nH]cc(Br)c(=O)c1Oc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O21 compound treatment 0.36 0.00587 0.3 0.367 0.00771 0.47 0.5415 0.9776 1908760 Bionet1_001339 Clc1ccc(c2ccc(/C=C/3\OC(=O)c4ccccc34)o2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O22 compound treatment 0.368 0.0139 0.71 0.365 0.00571 0.34 0.7454 0.945 1550875 Bionet1_001340 Cc1c(OCc2c(F)cccc2Cl)c(=O)ccn1Cc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O23 positive control 0.089 -0.265 -13.56 0.092 -0.267 -16.14 -20.9957 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 O24 positive control 0.094 -0.26 -13.3 0.096 -0.263 -15.89 -20.6441 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P01 mock treatment 0.362 0.00787 0.4 0.362 0.00271 0.16 0.4004 0.9212 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P02 mock treatment 0.356 0.00187 0.1 0.36 7.1E-4 0.04 0.0981 0.9341 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P03 compound treatment 0.379 0.0249 1.27 0.359 -2.9E-4 -0.02 0.887 0.6973 1520633 Bionet1_001341 CCOC(=O)CC1N(CCNC1=O)S(=O)(=O)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P04 compound treatment 0.348 -0.00613 -0.31 0.355 -0.00429 -0.26 -0.4046 -0.9955 1908761 Bionet1_001342 Fc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P05 compound treatment 0.361 0.00687 0.35 0.365 0.00571 0.34 0.4923 1.0 1590329 Bionet1_001343 CCOC(=O)CC1N(CCNC1=O)S(=O)(=O)c2ccc(NC(=O)C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P06 compound treatment 0.365 0.0109 0.56 0.379 0.0197 1.19 1.2345 0.94 1469037 Bionet1_001344 Clc1ccc(cc1Cl)N2C(=O)CS(=O)C(C2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P07 compound treatment 0.366 0.0119 0.61 0.361 0.00171 0.1 0.5023 0.8156 1908762 Bionet1_001345 CCOC(=O)CC1N(CCNC1=O)S(=O)(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P08 compound treatment 0.356 0.00187 0.1 0.366 0.00671 0.41 0.3542 0.851 1342855 Bionet1_001346 Fc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P09 compound treatment 0.355 8.75E-4 0.04 0.363 0.00371 0.22 0.19 0.8319 1497979 Bionet1_001347 CCOC(=O)CC1N(CCNC1=O)S(=O)(=O)c2ccc(OC)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P10 compound treatment 0.35 -0.00413 -0.21 0.363 0.00371 0.22 0.0092 0.0299 1158365 Bionet1_001348 Fc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P11 compound treatment 0.361 0.00687 0.35 0.356 -0.00329 -0.2 0.1081 0.2678 1908763 Bionet1_001349 CCOC(=O)CC1N(CCNC1=O)C(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P12 compound treatment 0.352 -0.00213 -0.11 0.359 -2.9E-4 -0.02 -0.0892 -0.8107 1339555 Bionet1_001350 Fc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P13 compound treatment 0.369 0.0149 0.76 0.357 -0.00229 -0.14 0.4401 0.5692 1395153 Bionet1_001351 CCOC(=O)CC1N(CCNC1=O)C(=O)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P14 compound treatment 0.355 8.75E-4 0.04 0.361 0.00171 0.1 0.1046 0.93 1908764 Bionet1_001352 Fc1ccc(cc1)c2ccc(C#N)c(=O)n2Cc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P15 compound treatment 0.36 0.00587 0.3 0.365 0.00571 0.34 0.4561 0.9977 1356900 Bionet1_001353 CCOC(=O)CC1N(CCNC1=O)C(=O)c2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P16 compound treatment 0.356 0.00187 0.1 0.365 0.00571 0.34 0.3115 0.8707 1908765 Bionet1_001354 FC(F)(F)c1ccc(cc1)N2C(=O)CSC(C2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P17 compound treatment 0.361 0.00687 0.35 0.368 0.00871 0.53 0.6204 0.9808 1246095 Bionet1_001355 CCOC(=O)CC1N(CCNC1=O)C(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P18 compound treatment 0.363 0.00887 0.45 0.357 -0.00229 -0.14 0.2231 0.4703 1908766 Bionet1_001356 C/C(=C\C(=O)Nc1ccccc1Cl)/N2CCN(CC2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P19 compound treatment 0.368 0.0139 0.71 0.356 -0.00329 -0.2 0.3612 0.4903 1201963 Bionet1_001357 CCOC(=O)CC1N(CCNC1=O)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P20 compound treatment 0.359 0.00487 0.25 0.364 0.00471 0.28 0.3773 0.9979 1196283 Bionet1_001358 CCOC(=O)c1cc(C(=O)OCC)c(=O)n(NC(=O)c2ccccc2)c1N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P21 compound treatment 0.356 0.00187 0.1 0.355 -0.00429 -0.26 -0.1153 -0.4177 1420464 Bionet1_001359 CCOC(=O)CC1N(CCNC1=O)S(=O)(=O)c2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P22 compound treatment 0.353 -0.00113 -0.06 0.353 -0.00629 -0.38 -0.3092 -0.805 1335658 Bionet1_001360 CCOC(=O)c1cc(C(=O)OCC)c(=O)n(NC(=O)c2cccnc2)c1N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P23 positive control 0.089 -0.265 -13.56 0.092 -0.267 -16.14 -20.9957 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.571 P24 positive control 0.096 -0.258 -13.2 0.097 -0.262 -15.83 -20.5291 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A01 mock treatment 0.332 -0.0245 -1.25 0.318 -0.0319 -1.93 -2.2477 -0.9783 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A02 mock treatment 0.329 -0.0275 -1.41 0.323 -0.0269 -1.62 -2.1427 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A03 compound treatment 0.328 -0.0285 -1.46 0.334 -0.0159 -0.96 -1.7093 -0.9795 1277576 Bionet1_001361 Cc1ccc(Cn2ccc(=O)c(OCc3c(F)cccc3Cl)c2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A04 compound treatment 0.329 -0.0275 -1.41 0.329 -0.0209 -1.26 -1.8866 -0.9985 1274478 Bionet1_001362 COC(=O)c1ccc(CN2C(=O)C(C)N(C(=O)C3CC3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A05 compound treatment 0.329 -0.0275 -1.41 0.318 -0.0319 -1.93 -2.3561 -0.988 1645956 Bionet1_001363 Cc1c(OCc2c(F)cccc2Cl)c(=O)ccn1Cc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A06 compound treatment 0.331 -0.0255 -1.3 0.322 -0.0279 -1.68 -2.1131 -0.992 1692094 Bionet1_001364 CC(C)n1cnc2c(NS(=O)(=O)c3ccc(C)cc3)c(C)c(C)cc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A07 compound treatment 0.325 -0.0315 -1.61 0.323 -0.0269 -1.62 -2.2873 -1.0 1908767 Bionet1_001365 Clc1ccc(Cn2c(/C=C/c3ccccc3)nc4ccccc24)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A08 compound treatment 0.325 -0.0315 -1.61 0.318 -0.0319 -1.93 -2.5008 -0.996 1698919 Bionet1_001366 CC(C)n1cnc2c(NS(=O)(=O)c3ccc(Cl)cc3)c(C)c(C)cc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A09 compound treatment 0.323 -0.0335 -1.71 0.315 -0.0349 -2.11 -2.7011 -0.9947 1908768 Bionet1_001367 Clc1cccc(Cl)c1Cn2c(/C=C/c3ccccc3)nc4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A10 compound treatment 0.324 -0.0325 -1.66 0.321 -0.0289 -1.74 -2.4089 -0.9997 1273999 Bionet1_001368 CC(C)n1cnc2c(NS(=O)(=O)c3ccc(F)cc3)c(C)c(C)cc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A11 compound treatment 0.327 -0.0295 -1.51 0.318 -0.0319 -1.93 -2.4285 -0.9927 1908769 Bionet1_001369 CC(C)(C)c1ccc(Cn2c(/C=C/c3ccccc3)nc4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A12 compound treatment 0.329 -0.0275 -1.41 0.324 -0.0259 -1.56 -2.1 -0.9986 1245414 Bionet1_001370 CC(C)n1cnc2c(NS(=O)(=O)c3ccccc3Cl)c(C)c(C)cc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A13 compound treatment 0.327 -0.0295 -1.51 0.322 -0.0279 -1.68 -2.2577 -0.9985 1908770 Bionet1_001371 Cc1cc2nc(/C=C/c3ccccc3)n(Cc4cccc(F)c4)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A14 compound treatment 0.328 -0.0285 -1.46 0.317 -0.0329 -1.99 -2.435 -0.9884 1233334 Bionet1_001372 COc1ccc(Cn2cc(cc(C#N)c2=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A15 compound treatment 0.324 -0.0325 -1.66 0.321 -0.0289 -1.74 -2.4089 -0.9997 1908771 Bionet1_001373 Cc1cc2nc(/C=C/c3ccccc3)n(Cc4ccc(cc4)C(C)(C)C)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A16 compound treatment 0.33 -0.0265 -1.36 0.321 -0.0289 -1.74 -2.1919 -0.9922 1702974 Bionet1_001374 Clc1ccc(cc1)c2cc(C#N)c(=O)n(Cc3ccc(Cl)cc3Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A17 compound treatment 0.328 -0.0285 -1.46 0.319 -0.0309 -1.87 -2.3496 -0.9925 1908772 Bionet1_001375 COc1cccc(Cn2c(/C=C/c3ccccc3)nc4cc(C)c(C)cc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A18 compound treatment 0.337 -0.0195 -1.0 0.329 -0.0209 -1.26 -1.5973 -0.9932 1908773 Bionet1_001376 Cc1cccc(Cn2cnc3c(NS(=O)(=O)C(F)(F)F)c(C)c(C)cc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A19 compound treatment 0.327 -0.0295 -1.51 0.319 -0.0309 -1.87 -2.3858 -0.9944 1908774 Bionet1_001377 Cc1cc2nc(/C=C/c3ccccc3)n(Cc4ccc(C#N)cc4)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A20 compound treatment 0.317 -0.0395 -2.02 0.319 -0.0309 -1.87 -2.7473 -0.9992 1320477 Bionet1_001378 CCCn1cnc2c(NS(=O)(=O)c3ccc(OC)cc3)c(C)c(C)cc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A21 compound treatment 0.334 -0.0225 -1.15 0.317 -0.0329 -1.99 -2.218 -0.9663 1908775 Bionet1_001379 Cc1cc2nc(/C=C/c3ccccc3)n(Cc4ccc(Cl)cc4)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A22 compound treatment 0.329 -0.0275 -1.41 0.32 -0.0299 -1.81 -2.2708 -0.9924 1477659 Bionet1_001380 CCCn1cnc2c(NS(=O)(=O)c3ccc(F)cc3)c(C)c(C)cc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A23 positive control 0.087 -0.27 -13.78 0.088 -0.262 -15.81 -20.9239 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 A24 positive control 0.087 -0.27 -13.78 0.089 -0.261 -15.75 -20.8812 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B01 mock treatment 0.356 -5.0E-4 -0.03 0.353 0.0031 0.19 0.1141 0.6048 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B02 mock treatment 0.365 0.0085 0.43 0.356 0.0061 0.37 0.5676 0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B03 compound treatment 0.369 0.0125 0.64 0.363 0.0131 0.79 1.011 0.9944 1535596 Bionet1_001381 Cc1nn(C)c(Oc2ccc(Cl)cc2)c1C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B04 compound treatment 0.373 0.0165 0.84 0.358 0.0081 0.49 0.9422 0.9663 1908776 Bionet1_001382 [O-][N+](=O)c1ccc(CSc2ncc(cn2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B05 compound treatment 0.365 0.0085 0.43 0.366 0.0161 0.97 0.9944 0.9342 1908777 Bionet1_001383 Cc1nn(C)c(Oc2cccc(c2)C(F)(F)F)c1C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B06 compound treatment 0.37 0.0135 0.69 0.352 0.0021 0.13 0.5776 0.823 1908778 Bionet1_001384 Clc1ccc(cc1)c2cnc(SCc3ccc(Cl)cc3Cl)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B07 compound treatment 0.375 0.0185 0.95 0.359 0.0091 0.55 1.0572 0.9665 1908779 Bionet1_001385 Cc1nn(C)c(Sc2ccc(Cl)cc2)c1C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B08 compound treatment 0.369 0.0125 0.64 0.351 0.0011 0.07 0.4988 0.7762 1136799 Bionet1_001386 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CSc2ccc(C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B09 compound treatment 0.364 0.0075 0.38 0.358 0.0081 0.49 0.6168 0.9928 1908780 Bionet1_001387 Cc1nn(C)c(Sc2ccc(Cl)cc2)c1C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B10 compound treatment 0.362 0.0055 0.28 0.35 9.68E-5 0.01 0.203 0.7216 1572137 Bionet1_001388 CN(C)C(=S)Oc1c(C)cc(cc1C)C(=O)CSc2ccc(C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B11 compound treatment 0.371 0.0145 0.74 0.361 0.0111 0.67 0.9979 0.9987 1908781 Bionet1_001389 Cc1nn(C)c(Sc2cccc(Cl)c2)c1C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B12 compound treatment 0.371 0.0145 0.74 0.361 0.0111 0.67 0.9979 0.9987 1477329 Bionet1_001390 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CSc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B13 compound treatment 0.364 0.0075 0.38 0.359 0.0091 0.55 0.6595 0.9846 1908782 Bionet1_001391 Cc1nn(C)c(Sc2cccc(Cl)c2)c1C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B14 compound treatment 0.362 0.0055 0.28 0.354 0.0041 0.25 0.3737 0.9979 1305385 Bionet1_001392 CN(C)C(=S)Oc1c(C)cc(cc1C)C(=O)CSc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B15 compound treatment 0.365 0.0085 0.43 0.354 0.0041 0.25 0.4822 0.9643 1162146 Bionet1_001393 Clc1ccc(Sc2nnc(Cc3ccccc3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B16 compound treatment 0.375 0.0185 0.95 0.359 0.0091 0.55 1.0572 0.9665 1506007 Bionet1_001394 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CS(=O)(=O)c2ccc(C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B17 compound treatment 0.353 -0.0035 -0.18 0.345 -0.0049 -0.3 -0.3358 -0.971 1421362 Bionet1_001395 COc1ccc(CNc2nnc(Cc3ccccc3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B18 compound treatment 0.373 0.0165 0.84 0.365 0.0151 0.91 1.241 0.9993 1596612 Bionet1_001396 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CS(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B19 compound treatment 0.364 0.0075 0.38 0.356 0.0061 0.37 0.5314 0.9998 1369090 Bionet1_001397 CC(O)(CS(=O)(=O)c1ccccc1)C(=O)Nc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B20 compound treatment 0.374 0.0175 0.89 0.362 0.0121 0.73 1.1491 0.9949 1332510 Bionet1_001398 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CS(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B21 compound treatment 0.358 0.0015 0.08 0.354 0.0041 0.25 0.2291 0.8848 1569787 Bionet1_001399 CC(O)(CSc1ccc(Cl)cc1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B22 compound treatment 0.308 -0.0485 -2.48 0.364 0.0141 0.85 -1.1518 -0.4393 1654914 Bionet1_001400 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CS(=O)(=O)c2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B23 positive control 0.087 -0.27 -13.78 0.089 -0.261 -15.75 -20.8812 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 B24 positive control 0.088 -0.269 -13.73 0.089 -0.261 -15.75 -20.845 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C01 mock treatment 0.358 0.0015 0.08 0.351 0.0011 0.07 0.1011 0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C02 mock treatment 0.367 0.0105 0.54 0.357 0.0071 0.43 0.6826 0.9937 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C03 compound treatment 0.358 0.0015 0.08 0.358 0.0081 0.49 0.3999 0.8082 1908783 Bionet1_001401 COC(=O)c1ccc(Cn2c(/C=C/c3ccccc3)nc4cc(C)c(C)cc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C04 compound treatment 0.362 0.0055 0.28 0.362 0.0121 0.73 0.7152 0.914 1908784 Bionet1_001402 CC1=CSC2=[N+](CC(=O)c3ccc(Cl)cc3)CCN12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C05 compound treatment 0.367 0.0105 0.54 0.36 0.0101 0.61 0.8106 0.998 1908785 Bionet1_001403 Clc1ccc(/C=C/c2nc3ccccc3n2Cc4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C06 compound treatment 0.364 0.0075 0.38 0.345 -0.0049 -0.3 0.0619 0.1277 1325136 Bionet1_001404 Clc1cccc(Cl)c1Cn2cc(cc(C#N)c2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C07 compound treatment 0.364 0.0075 0.38 0.347 -0.0029 -0.18 0.1472 0.3492 1908786 Bionet1_001405 Cc1ccc(Cn2c(/C=C/c3ccc(Cl)cc3Cl)nc4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C08 compound treatment 0.361 0.0045 0.23 0.349 -9.03E-4 -0.05 0.1241 0.525 1908787 Bionet1_001406 FC(F)(F)c1cccc(Cn2cc(cc(C#N)c2=O)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C09 compound treatment 0.358 0.0015 0.08 0.355 0.0051 0.31 0.2718 0.8571 1908788 Bionet1_001407 COc1cnc(nc1Sc2ccc(Cl)cc2Cl)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C10 compound treatment 0.356 -5.0E-4 -0.03 0.342 -0.0079 -0.48 -0.3554 -0.7439 1718993 Bionet1_001408 Clc1ccc(cc1)c2cc(C#N)c(=O)n(Cc3ccc(Cl)c(Cl)c3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C11 compound treatment 0.354 -0.0025 -0.13 0.345 -0.0049 -0.3 -0.2997 -0.9295 1908789 Bionet1_001409 CCOC(=O)Cn1c(/C=C/c2ccc(Cl)cc2Cl)nc3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C12 compound treatment 0.354 -0.0025 -0.13 0.351 0.0011 0.07 -0.0436 -0.3027 1730545 Bionet1_001410 Clc1ccc(cc1)c2cc(C#N)c(=O)n(Cc3c(Cl)cccc3Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C13 compound treatment 0.365 0.0085 0.43 0.348 -0.0019 -0.11 0.2261 0.5029 1908790 Bionet1_001411 COc1cccc(Cn2c(/C=C/c3ccccc3Cl)nc4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C14 compound treatment 0.354 -0.0025 -0.13 0.341 -0.0089 -0.54 -0.4704 -0.8515 1908791 Bionet1_001412 FC(F)(F)c1cccc(Cn2cc(cc(C#N)c2=O)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C15 compound treatment 0.356 -5.0E-4 -0.03 0.344 -0.0059 -0.36 -0.2701 -0.7559 1908792 Bionet1_001413 Fc1cccc(Cl)c1Cn2c(/C=C/c3ccccc3Cl)nc4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C16 compound treatment 0.349 -0.0075 -0.38 0.35 9.68E-5 0.01 -0.267 -0.6963 1150783 Bionet1_001414 Clc1cccc(Cn2cc(cc(C#N)c2=O)c3cccc(Cl)c3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C17 compound treatment 0.359 0.0025 0.13 0.35 9.68E-5 0.01 0.0945 0.7387 1908793 Bionet1_001415 Clc1cccc(Cn2c(/C=C/c3ccccc3Cl)nc4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C18 compound treatment 0.352 -0.0045 -0.23 0.35 9.68E-5 0.01 -0.1586 -0.6889 1633434 Bionet1_001416 Clc1cccc(c1)c2cc(C#N)c(=O)n(Cc3ccc(Cl)cc3Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C19 compound treatment 0.358 0.0015 0.08 0.349 -9.03E-4 -0.05 0.0157 0.1666 1908794 Bionet1_001417 Fc1cccc(Cn2c(/C=C/c3ccccc3Cl)nc4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C20 compound treatment 0.354 -0.0025 -0.13 0.346 -0.0039 -0.24 -0.257 -0.9587 1123613 Bionet1_001418 COc1ccc(Sc2ncc(cc2C#N)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C21 compound treatment 0.367 0.0105 0.54 0.355 0.0051 0.31 0.5972 0.9651 1908795 Bionet1_001419 Clc1ccc(Cn2c(/C=C/c3ccccc3Cl)nc4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C22 compound treatment 0.357 5.0E-4 0.03 0.346 -0.0039 -0.24 -0.1485 -0.6267 1326244 Bionet1_001420 Clc1ccc(cc1)c2cnc(Sc3ccccc3Cl)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C23 positive control 0.083 -0.274 -13.98 0.084 -0.266 -16.05 -21.2393 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 C24 positive control 0.087 -0.27 -13.78 0.09 -0.26 -15.69 -20.8385 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D01 mock treatment 0.346 -0.0105 -0.54 0.342 -0.0079 -0.48 -0.717 -0.9983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D02 mock treatment 0.356 -5.0E-4 -0.03 0.347 -0.0029 -0.18 -0.142 -0.8018 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D03 compound treatment 0.351 -0.0055 -0.28 0.345 -0.0049 -0.3 -0.4082 -0.9997 1908796 Bionet1_001421 CC(O)(CS(=O)(=O)c1ccccc1)C(=O)Nc2ccc(cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D04 compound treatment 0.365 0.0085 0.43 0.361 0.0111 0.67 0.781 0.9781 1544202 Bionet1_001422 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CS(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D05 compound treatment 0.36 0.0035 0.18 0.346 -0.0039 -0.24 -0.0401 -0.1354 1908797 Bionet1_001423 CC(O)(CS(=O)(=O)C1CCCCC1)C(=O)Nc2ccc(cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D06 compound treatment 0.361 0.0045 0.23 0.354 0.0041 0.25 0.3376 0.9994 1179427 Bionet1_001424 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CS(=O)c2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D07 compound treatment 0.352 -0.0045 -0.23 0.346 -0.0039 -0.24 -0.3293 -0.9999 1908798 Bionet1_001425 COc1ccc(SCC(C)(O)C(=O)Nc2ccc(cc2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D08 compound treatment 0.352 -0.0045 -0.23 0.337 -0.0129 -0.78 -0.7135 -0.8785 1908799 Bionet1_001426 COc1ccc(cc1OC)C(=O)NCCSc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D09 compound treatment 0.348 -0.0085 -0.43 0.354 0.0041 0.25 -0.1324 -0.2649 1224308 Bionet1_001427 COc1cccc(Cn2cnc3c(NS(=O)(=O)C)c(C)c(C)cc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D10 compound treatment 0.35 -0.0065 -0.33 0.346 -0.0039 -0.24 -0.4016 -0.9858 1908800 Bionet1_001428 COc1cc(cc(OC)c1OC)C(=O)NCCSc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D11 compound treatment 0.351 -0.0055 -0.28 0.352 0.0021 0.13 -0.1094 -0.3546 1723827 Bionet1_001429 Cc1cccc(Cn2c(nc3cc(C)c(C)cc23)c4cccnc4Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D12 compound treatment 0.347 -0.0095 -0.49 0.343 -0.0069 -0.42 -0.6382 -0.9971 1908801 Bionet1_001430 Clc1ccc(Sc2ncccc2c3nc4ccccc4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D13 compound treatment 0.358 0.0015 0.08 0.362 0.0121 0.73 0.5706 0.7771 1337830 Bionet1_001431 Cc1cc2nc(c3cccnc3Cl)n(Cc4ccccc4Cl)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D14 compound treatment 0.349 -0.0075 -0.38 0.34 -0.0099 -0.6 -0.6939 -0.977 1908802 Bionet1_001432 FC(F)(F)c1cccc(Sc2ncccc2c3nc4ccccc4s3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D15 compound treatment 0.364 0.0075 0.38 0.357 0.0071 0.43 0.5741 0.9985 1622607 Bionet1_001433 Cc1cc2nc(c3cccnc3Cl)n(Cc4ccc(F)cc4)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D16 compound treatment 0.349 -0.0075 -0.38 0.341 -0.0089 -0.54 -0.6512 -0.9863 1908803 Bionet1_001434 COc1ccc(Cn2c(nc3ccccc23)c4ccc(Cl)nc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D17 compound treatment 0.361 0.0045 0.23 0.35 9.68E-5 0.01 0.1668 0.7248 1460082 Bionet1_001435 Cc1ccccc1Cn2c(nc3cc(C)c(C)cc23)c4cccnc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D18 compound treatment 0.36 0.0035 0.18 0.342 -0.0079 -0.48 -0.2108 -0.4137 1908804 Bionet1_001436 FC(F)(F)c1cccc(Cn2c(nc3ccccc23)c4ccc(Cl)nc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D19 compound treatment 0.364 0.0075 0.38 0.353 0.0031 0.19 0.4034 0.9455 1678707 Bionet1_001437 Cc1cc2nc(c3cccnc3Cl)n(Cc4ccccc4F)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D20 compound treatment 0.356 -5.0E-4 -0.03 0.354 0.0041 0.25 0.1568 0.6306 1611698 Bionet1_001438 COC(=O)c1c(C(=O)OC)c2CSCn2c1c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D21 compound treatment 0.355 -0.0015 -0.08 0.348 -0.0019 -0.11 -0.1355 -0.9807 1477920 Bionet1_001439 Clc1ccc(Oc2nnc(Cc3ccccc3)c4ccccc24)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D22 compound treatment 0.355 -0.0015 -0.08 0.347 -0.0029 -0.18 -0.1782 -0.9313 1580425 Bionet1_001440 COC(=O)c1c(C(=O)OC)c2CS(=O)(=O)Cn2c1c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D23 positive control 0.085 -0.272 -13.88 0.086 -0.264 -15.93 -21.0816 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 D24 positive control 0.089 -0.268 -13.68 0.091 -0.259 -15.63 -20.7235 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E01 mock treatment 0.35 -0.0065 -0.33 0.349 -9.03E-4 -0.05 -0.2736 -0.8123 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E02 mock treatment 0.365 0.0085 0.43 0.355 0.0051 0.31 0.5249 0.9857 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E03 compound treatment 0.367 0.0105 0.54 0.358 0.0081 0.49 0.7253 0.9989 1908805 Bionet1_001441 Clc1ccccc1/C=C/c2nc3ccccc3n2Cc4cccc(C#N)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E04 compound treatment 0.356 -5.0E-4 -0.03 0.345 -0.0049 -0.3 -0.2274 -0.7653 1480589 Bionet1_001442 Clc1ccc(cc1)c2cnc(Sc3cccc(Cl)c3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E05 compound treatment 0.36 0.0035 0.18 0.348 -0.0019 -0.11 0.0453 0.213 1908806 Bionet1_001443 FC(F)(F)c1cnc(C(c2nc[nH]n2)c3ccc(Cl)cc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E06 compound treatment 0.36 0.0035 0.18 0.362 0.0121 0.73 0.6429 0.8551 1274264 Bionet1_001444 Clc1ccc(Sc2ncc(cc2C#N)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E07 compound treatment 0.367 0.0105 0.54 0.358 0.0081 0.49 0.7253 0.9989 1908807 Bionet1_001445 COc1cnc(nc1Oc2ccc(Cl)c3ccccc23)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E08 compound treatment 0.361 0.0045 0.23 0.348 -0.0019 -0.11 0.0815 0.3167 1447550 Bionet1_001446 Clc1ccc(cc1)c2cnc(Sc3c(Cl)cccc3Cl)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E09 compound treatment 0.362 0.0055 0.28 0.342 -0.0079 -0.48 -0.1385 -0.2501 1908808 Bionet1_001447 COc1cnc(SCc2ccc(Cl)cc2)nc1Sc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E10 compound treatment 0.351 -0.0055 -0.28 0.346 -0.0039 -0.24 -0.3655 -0.9961 1908809 Bionet1_001448 FC(F)(F)c1cccc(Oc2ncc(cc2C#N)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E11 compound treatment 0.366 0.0095 0.49 0.356 0.0061 0.37 0.6037 0.9906 1908810 Bionet1_001449 COc1cnc(SCc2ccc(Cl)cc2)nc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E12 compound treatment 0.355 -0.0015 -0.08 0.35 9.68E-5 0.01 -0.0501 -0.6514 1282964 Bionet1_001450 Clc1cccc(c1)c2cc(C#N)c(=O)n(Cc3c(Cl)cccc3Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E13 compound treatment 0.358 0.0015 0.08 0.354 0.0041 0.25 0.2291 0.8848 1908811 Bionet1_001451 COc1cnc(SCc2ccc(Cl)cc2)nc1Oc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E14 compound treatment 0.348 -0.0085 -0.43 0.342 -0.0079 -0.48 -0.6447 -0.9989 1908812 Bionet1_001452 FC(F)(F)c1cccc(Oc2ncc(cc2C#N)c3cccc(Cl)c3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E15 compound treatment 0.364 0.0075 0.38 0.368 0.0181 1.09 1.0437 0.9014 1908813 Bionet1_001453 CCOC(=O)CSc1ncc(OC)c(Sc2ccc(Cl)cc2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E16 compound treatment 0.362 0.0055 0.28 0.358 0.0081 0.49 0.5445 0.9655 1139505 Bionet1_001454 Clc1ccc(NC(=O)N2OCC3COc4ccc5ccccc5c4C32)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E17 compound treatment 0.364 0.0075 0.38 0.35 9.68E-5 0.01 0.2753 0.7178 1908814 Bionet1_001455 CCOC(=O)CSc1ncc(OC)c(Sc2ccc(OC)cc2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E18 compound treatment 0.365 0.0085 0.43 0.348 -0.0019 -0.11 0.2261 0.5029 1457321 Bionet1_001456 Clc1ccc(cc1)C(=O)N2OCC3COc4ccc5ccccc5c4C32 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E19 compound treatment 0.369 0.0125 0.64 0.357 0.0071 0.43 0.7549 0.9811 1908815 Bionet1_001457 CCOC(=O)CSc1ncc(OC)c(Oc2ccc(Cl)c(Cl)c2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E20 compound treatment 0.37 0.0135 0.69 0.36 0.0101 0.61 0.9191 0.9981 1172613 Bionet1_001458 O=C(NC(=S)N1OC[C@@H]2COc3ccc4ccccc4c3[C@@H]21)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E21 compound treatment 0.371 0.0145 0.74 0.355 0.0051 0.31 0.7418 0.9241 1908816 Bionet1_001459 CCOC(=O)CSc1ncc(OC)c(Oc2cccc(c2)[N+](=O)[O-])n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E22 compound treatment 0.362 0.0055 0.28 0.353 0.0031 0.19 0.331 0.9803 1908817 Bionet1_001460 CN1C(=O)N(C)C(=O)C(=Cc2c(OCC=C)ccc3ccccc23)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E23 positive control 0.086 -0.271 -13.83 0.086 -0.264 -15.93 -21.0454 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 E24 positive control 0.091 -0.266 -13.58 0.094 -0.256 -15.45 -20.5231 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F01 mock treatment 0.355 -0.0015 -0.08 0.349 -9.03E-4 -0.05 -0.0928 -0.986 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F02 mock treatment 0.361 0.0045 0.23 0.353 0.0031 0.19 0.2949 0.9947 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F03 compound treatment 0.368 0.0115 0.59 0.364 0.0141 0.85 1.0175 0.9837 1908818 Bionet1_001461 Cc1cc2nc(c3cccnc3Cl)n(Cc4cccc(Cl)c4)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F04 compound treatment 0.368 0.0115 0.59 0.356 0.0061 0.37 0.676 0.9745 1464474 Bionet1_001462 COC(=O)c1c(C(=O)OC)c2CS(=O)Cn2c1c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F05 compound treatment 0.366 0.0095 0.49 0.357 0.0071 0.43 0.6464 0.998 1595639 Bionet1_001463 Cc1cc2nc(c3cccnc3Cl)n(Cc4c(F)cccc4Cl)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F06 compound treatment 0.36 0.0035 0.18 0.352 0.0021 0.13 0.2161 0.9856 1697406 Bionet1_001464 COC(=O)c1c(C(=O)OC)c2CS(=O)(=O)Cn2c1c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F07 compound treatment 0.371 0.0145 0.74 0.355 0.0051 0.31 0.7418 0.9241 1497567 Bionet1_001465 COc1cccc(Cn2c(nc3cc(C)c(C)cc23)c4cccnc4Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F08 compound treatment 0.372 0.0155 0.79 0.365 0.0151 0.91 1.2049 0.9976 1456538 Bionet1_001466 COC(=O)c1c(C(=O)OC)c2CS(=O)Cn2c1c3ccc(cc3)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F09 compound treatment 0.366 0.0095 0.49 0.335 -0.0149 -0.9 -0.2927 -0.2863 1299705 Bionet1_001467 COc1ccc(Sc2nnc(Cc3ccccc3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F10 compound treatment 0.362 0.0055 0.28 0.355 0.0051 0.31 0.4164 0.999 1410089 Bionet1_001468 COC(=O)c1c(C(=O)OC)c2CSCn2c1c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F11 compound treatment 0.374 0.0175 0.89 0.366 0.0161 0.97 1.3199 0.9992 1908819 Bionet1_001469 COc1ccc(Oc2cccc3C(/C(=C/N(C)C)/C(=O)c32)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F12 compound treatment 0.37 0.0135 0.69 0.351 0.0011 0.07 0.5349 0.7714 1288290 Bionet1_001470 COC(=O)c1c(C(=O)OC)c2CS(=O)Cn2c1c3cccc(F)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F13 compound treatment 0.364 0.0075 0.38 0.352 0.0021 0.13 0.3607 0.8931 1908820 Bionet1_001471 CN(C)c1ccc(/C=C/C=C\2/C(c3ccccc3C2=O)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F14 compound treatment 0.375 0.0185 0.95 0.365 0.0151 0.91 1.3133 0.9998 1908821 Bionet1_001472 COC(=O)c1c(C(=O)OC)c2CSCn2c1c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F15 compound treatment 0.386 0.0295 1.51 0.372 0.0221 1.33 2.0098 0.9981 1908822 Bionet1_001473 COc1ccc(/C=C\2/C(c3ccccc3C2=O)c4ccccc4)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F16 compound treatment 0.366 0.0095 0.49 0.355 0.0051 0.31 0.561 0.9757 1339872 Bionet1_001474 Clc1ccc(Sc2ccc(nn2)C(C#N)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F17 compound treatment 0.369 0.0125 0.64 0.346 -0.0039 -0.24 0.2853 0.4189 1908823 Bionet1_001475 OC1CC(c2cccc(Oc3cccc(c3)C(F)(F)F)c12)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F18 compound treatment 0.368 0.0115 0.59 0.344 -0.0059 -0.36 0.1638 0.2382 1511401 Bionet1_001476 NC(=O)C(c1ccc(Cl)cc1)c2ccc(Sc3ccccc3)nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F19 compound treatment 0.374 0.0175 0.89 0.36 0.0101 0.61 1.0637 0.9825 1908824 Bionet1_001477 Fc1cccc2C(/C(=C\Nc3ccc(Cl)cc3)/C(=O)c21)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F20 compound treatment 0.364 0.0075 0.38 0.352 0.0021 0.13 0.3607 0.8931 1330119 Bionet1_001478 NC(=O)C(c1ccc(Cl)cc1)c2ccc(Sc3ccc(Cl)cc3)nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F21 compound treatment 0.37 0.0135 0.69 0.356 0.0061 0.37 0.7484 0.9566 1908825 Bionet1_001479 Fc1cccc2C(/C(=C\Nc3cccc(c3)C(F)(F)F)/C(=O)c21)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F22 compound treatment 0.366 0.0095 0.49 0.34 -0.0099 -0.6 -0.0793 -0.1029 1908826 Bionet1_001480 C/C(=N\OCc1ccc(cc1)[N+](=O)[O-])/CCS(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F23 positive control 0.09 -0.267 -13.63 0.087 -0.263 -15.87 -20.8581 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 F24 positive control 0.094 -0.263 -13.42 0.091 -0.259 -15.63 -20.5427 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G01 mock treatment 0.343 -0.0135 -0.69 0.346 -0.0039 -0.24 -0.6547 -0.8976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G02 mock treatment 0.357 5.0E-4 0.03 0.347 -0.0029 -0.18 -0.1059 -0.5976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G03 compound treatment 0.364 0.0075 0.38 0.354 0.0041 0.25 0.446 0.9775 1908827 Bionet1_001481 CCOC(=O)CSc1ncc(OC)c(Oc2ccc(OC)cc2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G04 compound treatment 0.36 0.0035 0.18 0.351 0.0011 0.07 0.1734 0.9085 1908828 Bionet1_001482 Cn1c2OC[C@H]3COc4ccc5ccccc5c4[C@H]3c2c(=O)n(C)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G05 compound treatment 0.362 0.0055 0.28 0.349 -9.03E-4 -0.05 0.1603 0.5596 1908829 Bionet1_001483 CCOC(=O)C(C)Sc1ncc(OC)c(Sc2ccc(Cl)cc2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G06 compound treatment 0.395 0.0385 1.97 0.377 0.0271 1.64 2.5487 0.9958 1256704 Bionet1_001484 Clc1ccc(cc1Cl)C(=O)N2OC[C@@H]3COc4ccc5ccccc5c4[C@@H]32 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G07 compound treatment 0.366 0.0095 0.49 0.338 -0.0119 -0.72 -0.1646 -0.1898 1908830 Bionet1_001485 Clc1ccc(SCCNC(=O)c2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G08 compound treatment 0.364 0.0075 0.38 0.348 -0.0019 -0.11 0.1899 0.4744 1908831 Bionet1_001486 O=C(CN1CCOCC1)N2OC[C@@H]3COc4ccc5ccccc5c4[C@@H]32 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G09 compound treatment 0.366 0.0095 0.49 0.345 -0.0049 -0.3 0.1342 0.2359 1187364 Bionet1_001487 Cc1ccc(Cn2ccc(=O)c(OCc3c(Cl)cccc3Cl)c2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G10 compound treatment 0.371 0.0145 0.74 0.359 0.0091 0.55 0.9126 0.9891 1908832 Bionet1_001488 OC[C@H]1COc2ccc3ccccc3c2[C@H]1NC(=O)Nc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G11 compound treatment 0.365 0.0085 0.43 0.371 0.0211 1.27 1.2079 0.8976 1336601 Bionet1_001489 Cc1c(OCc2c(Cl)cccc2Cl)c(=O)ccn1Cc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G12 compound treatment 0.39 0.0335 1.71 0.393 0.0431 2.6 3.0509 0.9794 1576493 Bionet1_001490 Clc1ccc(cc1)C2N[C@H]3[C@@H](CO2)COc4ccc5ccccc5c34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G13 compound treatment 0.342 -0.0145 -0.74 0.343 -0.0069 -0.42 -0.8189 -0.9629 1674938 Bionet1_001491 Cc1c(OCc2ccccc2)c(=O)ccn1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G14 compound treatment 0.354 -0.0025 -0.13 0.348 -0.0019 -0.11 -0.1716 -0.9986 1908833 Bionet1_001492 COc1cccc2[C@@H]([C@H](CO)COc12)N(C)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G15 compound treatment 0.397 0.0405 2.07 0.385 0.0351 2.12 2.9625 0.9999 1406416 Bionet1_001493 Cc1c(OCc2ccccc2)c(=O)ccn1Cc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G16 compound treatment 0.371 0.0145 0.74 0.358 0.0081 0.49 0.8699 0.9796 1556426 Bionet1_001494 COc1cccc(c1)C2OC[C@@H]3COc4ccc5ccccc5c4[C@@H]3N2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G17 compound treatment 0.355 -0.0015 -0.08 0.36 0.0101 0.61 0.3768 0.6133 1661200 Bionet1_001495 Cc1c(OCc2ccc(F)cc2)c(=O)ccn1Cc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G18 compound treatment 0.353 -0.0035 -0.18 0.341 -0.0089 -0.54 -0.5066 -0.8943 1908834 Bionet1_001496 O=C(N1OCC2COc3ccc4ccccc4c3C21)C5(CC6CC7CC(C6)C5)C7 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G19 compound treatment 0.363 0.0065 0.33 0.348 -0.0019 -0.11 0.1538 0.4373 1908835 Bionet1_001497 FC(F)(F)c1cccc(c1)C(=O)Nc2ncc3CCc4ccccc4-c3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G20 compound treatment 0.352 -0.0045 -0.23 0.338 -0.0119 -0.72 -0.6708 -0.8891 1908836 Bionet1_001498 CCCCCCCCCCC(=O)c1c[nH]c(c1)C(=O)C(Cl)(Cl)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G21 compound treatment 0.363 0.0065 0.33 0.347 -0.0029 -0.18 0.1111 0.2956 1648314 Bionet1_001499 Clc1ccc(NC(=O)Nc2ncc3CCc4ccccc4-c3n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G22 compound treatment 0.351 -0.0055 -0.28 0.338 -0.0119 -0.72 -0.707 -0.9162 1908837 Bionet1_001500 FC(F)(F)c1cnc(SC2CC(=O)N(C2=O)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G23 positive control 0.088 -0.269 -13.73 0.088 -0.262 -15.81 -20.8877 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 G24 positive control 0.092 -0.265 -13.52 0.093 -0.257 -15.51 -20.5297 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H01 mock treatment 0.356 -5.0E-4 -0.03 0.354 0.0041 0.25 0.1568 0.6306 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H02 mock treatment 0.369 0.0125 0.64 0.351 0.0011 0.07 0.4988 0.7762 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H03 compound treatment 0.359 0.0025 0.13 0.35 9.68E-5 0.01 0.0945 0.7387 1908838 Bionet1_001501 [O-][N+](=O)c1ccccc1N/C=C/2\C(c3cccc(F)c3C2=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H04 compound treatment 0.374 0.0175 0.89 0.356 0.0061 0.37 0.893 0.9229 1908839 Bionet1_001502 FC(F)(F)c1cnc(SC(C#N)c2ccc(Cl)cc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H05 compound treatment 0.391 0.0345 1.76 0.389 0.0391 2.36 2.9163 0.9897 1908840 Bionet1_001503 Fc1cccc2C(/C(=C\Nc3cccc(C#N)c3)/C(=O)c21)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H06 compound treatment 0.367 0.0105 0.54 0.345 -0.0049 -0.3 0.1703 0.2778 1908841 Bionet1_001504 FC(F)(F)c1cnc(SC(C#N)c2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H07 compound treatment 0.386 0.0295 1.51 0.365 0.0151 0.91 1.711 0.9709 1691069 Bionet1_001505 O=C1CC(c2cccc(N3CCN(CC3)c4ccccc4)c12)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H08 compound treatment 0.38 0.0235 1.2 0.351 0.0011 0.07 0.8965 0.7449 1335558 Bionet1_001506 Clc1ccc(CNc2nnc(Cc3ccccc3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H09 compound treatment 0.366 0.0095 0.49 0.366 0.0161 0.97 1.0306 0.9487 1520476 Bionet1_001507 Fc1ccc(cc1)N2CCN(CC2)c3cccc4C(CC(=O)c43)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H10 compound treatment 0.372 0.0155 0.79 0.352 0.0021 0.13 0.6499 0.8098 1908842 Bionet1_001508 FC(F)(F)c1cccc(c1)c2nc(no2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H11 compound treatment 0.373 0.0165 0.84 0.362 0.0121 0.73 1.1129 0.9974 1908843 Bionet1_001509 CN(C)/C=C\1/C(c2cccc(Oc3ccc(Cl)cc3)c2C1=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H12 compound treatment 0.363 0.0065 0.33 0.339 -0.0109 -0.66 -0.2304 -0.3125 1908844 Bionet1_001510 FC(F)(F)c1cnc(c(Cl)c1)c2cnc(Oc3ccccc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H13 compound treatment 0.355 -0.0015 -0.08 0.34 -0.0099 -0.6 -0.477 -0.7913 1908845 Bionet1_001511 FC(F)(F)c1cccc(Oc2cccc3C(CC(=O)c32)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H14 compound treatment 0.378 0.0215 1.1 0.375 0.0251 1.52 1.8487 0.9876 1908846 Bionet1_001512 Clc1cccc(c1)c2cnc(SCc3ccc(Cl)c(Cl)c3)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H15 compound treatment 0.357 5.0E-4 0.03 0.364 0.0141 0.85 0.6198 0.728 1908847 Bionet1_001513 CN(C)/C=C/1\CCc2c(cc(c3ccccc3)n2c4ccc(C)cc4)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H16 compound treatment 0.375 0.0185 0.95 0.365 0.0151 0.91 1.3133 0.9998 1908848 Bionet1_001514 Cn1c(SCc2ccc(Cl)c(Cl)c2)nc(cc1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H17 compound treatment 0.334 -0.0225 -1.15 0.326 -0.0239 -1.44 -1.8339 -0.9937 1908849 Bionet1_001515 Clc1ccc(cc1)C(=O)c2oc3ccccc3c2CBr 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H18 compound treatment 0.372 0.0155 0.79 0.362 0.0121 0.73 1.0768 0.9992 1908850 Bionet1_001516 Cn1c(SCc2ccc(Cl)cc2Cl)nc(cc1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H19 compound treatment 0.363 0.0065 0.33 0.353 0.0031 0.19 0.3672 0.963 1380683 Bionet1_001517 Clc1ccc(cc1)C(=O)c2oc3ccccc3c2CSc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H20 compound treatment 0.361 0.0045 0.23 0.361 0.0111 0.67 0.6364 0.8985 1908851 Bionet1_001518 Cn1c(SCc2c(Cl)cccc2Cl)nc(cc1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H21 compound treatment 0.362 0.0055 0.28 0.352 0.0021 0.13 0.2884 0.935 1736174 Bionet1_001519 Cc1ccc(cc1)S(=O)(=O)Cc2c(oc3ccccc23)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H22 compound treatment 0.351 -0.0055 -0.28 0.347 -0.0029 -0.18 -0.3228 -0.9741 1908852 Bionet1_001520 Cn1c(SCc2ccc(cc2)C(C)(C)C)nc(cc1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H23 positive control 0.087 -0.27 -13.78 0.086 -0.264 -15.93 -21.0093 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 H24 positive control 0.093 -0.264 -13.47 0.093 -0.257 -15.51 -20.4935 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I01 mock treatment 0.352 -0.0045 -0.23 0.345 -0.0049 -0.3 -0.372 -0.9922 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I02 mock treatment 0.365 0.0085 0.43 0.35 9.68E-5 0.01 0.3115 0.7165 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I03 compound treatment 0.366 0.0095 0.49 0.355 0.0051 0.31 0.561 0.9757 1308297 Bionet1_001521 Clc1cccc(NC(=O)Nc2ncc3CCc4ccccc4-c3n2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I04 compound treatment 0.359 0.0025 0.13 0.333 -0.0169 -1.02 -0.6312 -0.6137 1908853 Bionet1_001522 COc1ccc(cc1)C(CCC#N)(C#N)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I05 compound treatment 0.381 0.0245 1.25 0.353 0.0031 0.19 1.018 0.8037 1295409 Bionet1_001523 CC1N(C(=O)c2ccccc2)c3ccccc3N(Cc4cccc(Cl)c4)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I06 compound treatment 0.351 -0.0055 -0.28 0.339 -0.0109 -0.66 -0.6643 -0.9281 1908854 Bionet1_001524 COc1ccc(cc1)C2(CCC(=O)NC2=O)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I07 compound treatment 0.357 5.0E-4 0.03 0.342 -0.0079 -0.48 -0.3193 -0.6683 1140364 Bionet1_001525 CC1N(C(=O)c2ccccc2)c3ccccc3N(Cc4cccc(F)c4)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I08 compound treatment 0.357 5.0E-4 0.03 0.342 -0.0079 -0.48 -0.3193 -0.6683 1592764 Bionet1_001526 CC(O)(CS(=O)(=O)c1ccccc1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I09 compound treatment 0.355 -0.0015 -0.08 0.351 0.0011 0.07 -0.0074 -0.0732 1579010 Bionet1_001527 COc1cccc(CN2C(=O)C(C)N(C(=O)c3ccccc3)c4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I10 compound treatment 0.359 0.0025 0.13 0.345 -0.0049 -0.3 -0.1189 -0.3688 1250843 Bionet1_001528 CC(O)(CS(=O)(=O)C1CCCCC1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I11 compound treatment 0.37 0.0135 0.69 0.358 0.0081 0.49 0.8337 0.9857 1354171 Bionet1_001529 CC1N(C(=O)c2ccccc2)c3ccccc3N(Cc4ccccc4Cl)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I12 compound treatment 0.348 -0.0085 -0.43 0.353 0.0031 0.19 -0.1751 -0.3702 1394922 Bionet1_001530 CC(O)(CS(=O)c1ccc(Cl)cc1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I13 compound treatment 0.349 -0.0075 -0.38 0.354 0.0041 0.25 -0.0963 -0.211 1391776 Bionet1_001531 CC1N(C(=O)c2ccccc2)c3ccccc3N(Cc4ccccc4)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I14 compound treatment 0.355 -0.0015 -0.08 0.359 0.0091 0.55 0.3341 0.6025 1420403 Bionet1_001532 CC(O)(CS(=O)(=O)c1cccc(Cl)c1)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I15 compound treatment 0.368 0.0115 0.59 0.349 -9.03E-4 -0.05 0.3772 0.6388 1908855 Bionet1_001533 COc1cnc(nc1Sc2c(Cl)cccc2Cl)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I16 compound treatment 0.356 -5.0E-4 -0.03 0.341 -0.0089 -0.54 -0.3981 -0.7399 1255363 Bionet1_001534 Cc1ccc(cc1)S(=O)(=O)CC(C)(O)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I17 compound treatment 0.361 0.0045 0.23 0.363 0.0131 0.79 0.7218 0.8765 1908856 Bionet1_001535 FC(F)(F)c1cccc(NC(=O)Nc2ncc3CCc4ccccc4-c3n2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I18 compound treatment 0.364 0.0075 0.38 0.368 0.0181 1.09 1.0437 0.9014 1687284 Bionet1_001536 COc1ccc(cc1)S(=O)(=O)CC(C)(O)C(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I19 compound treatment 0.365 0.0085 0.43 0.351 0.0011 0.07 0.3541 0.8055 1683343 Bionet1_001537 Cc1cc2n(C)cnc2c(NS(=O)(=O)c3ccc(Cl)cc3)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I20 compound treatment 0.368 0.0115 0.59 0.338 -0.0119 -0.72 -0.0923 -0.0994 1908857 Bionet1_001538 CC(O)(CS(=O)(=O)c1ccccc1)C(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I21 compound treatment 0.351 -0.0055 -0.28 0.356 0.0061 0.37 0.0614 0.1325 1340803 Bionet1_001539 Cc1cc2n(C)cnc2c(NS(=O)(=O)c3cc(Cl)ccc3Cl)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I22 compound treatment 0.361 0.0045 0.23 0.344 -0.0059 -0.36 -0.0893 -0.2105 1908858 Bionet1_001540 COc1cnc(SCc2ccc(Cl)c(Cl)c2)nc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I23 positive control 0.087 -0.27 -13.78 0.09 -0.26 -15.69 -20.8385 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 I24 positive control 0.095 -0.262 -13.37 0.095 -0.255 -15.39 -20.3358 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J01 mock treatment 0.352 -0.0045 -0.23 0.349 -9.03E-4 -0.05 -0.2013 -0.8511 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J02 mock treatment 0.362 0.0055 0.28 0.356 0.0061 0.37 0.4591 0.9912 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J03 compound treatment 0.407 0.0505 2.58 0.404 0.0541 3.27 4.1351 0.9932 1539254 Bionet1_001541 Clc1ccccc1SCc2c(oc3ccccc23)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J04 compound treatment 0.379 0.0225 1.15 0.371 0.0211 1.27 1.7141 0.9987 1908859 Bionet1_001542 FC(F)(F)c1cccc(c1)c2cnc(SCc3ccc(Cl)cc3)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J05 compound treatment 0.397 0.0405 2.07 0.387 0.0371 2.24 3.0479 0.9992 1158460 Bionet1_001543 Clc1ccc(SCc2c(oc3ccccc23)C(=O)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J06 compound treatment 0.363 0.0065 0.33 0.352 0.0021 0.13 0.3245 0.9125 1908860 Bionet1_001544 COC(=O)c1ccc(CSc2nc(cc(=O)n2C)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J07 compound treatment 0.377 0.0205 1.05 0.367 0.0171 1.03 1.471 1.0 1570403 Bionet1_001545 COc1ccc(SCc2c(oc3ccccc23)C(=O)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J08 compound treatment 0.376 0.0195 1.0 0.348 -0.0019 -0.11 0.6238 0.6215 1908861 Bionet1_001546 Cn1c(SCc2cccc(c2)C(F)(F)F)nc(cc1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J09 compound treatment 0.385 0.0285 1.46 0.387 0.0371 2.24 2.614 0.9783 1451234 Bionet1_001547 Cc1ccccc1SCc2c(oc3ccccc23)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J10 compound treatment 0.356 -5.0E-4 -0.03 0.344 -0.0059 -0.36 -0.2701 -0.7559 1908862 Bionet1_001548 Cn1c(SCc2c(F)cccc2Cl)nc(cc1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J11 compound treatment 0.349 -0.0075 -0.38 0.343 -0.0069 -0.42 -0.5658 -0.9991 1658679 Bionet1_001549 COc1ccc(cc1)S(=O)Cc2c(oc3ccccc23)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J12 compound treatment 0.37 0.0135 0.69 0.362 0.0121 0.73 1.0045 0.9996 1908863 Bionet1_001550 Cc1cccc(CSc2ncc(cn2)c3cccc(c3)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J13 compound treatment 0.39 0.0335 1.71 0.379 0.0291 1.76 2.4533 0.9999 1908864 Bionet1_001551 Clc1cccc(c1)c2cnn(c2)c3ccc(Cl)c(Cl)c3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J14 compound treatment 0.37 0.0135 0.69 0.36 0.0101 0.61 0.9191 0.9981 1908865 Bionet1_001552 FC(F)(F)c1cccc(c1)c2cnc(SCc3ccccc3Cl)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J15 compound treatment 0.35 -0.0065 -0.33 0.343 -0.0069 -0.42 -0.5297 -0.9937 1908866 Bionet1_001553 Clc1snnc1CO/N=C\C2C(=O)CC(CC2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J16 compound treatment 0.375 0.0185 0.95 0.368 0.0181 1.09 1.4414 0.9974 1908867 Bionet1_001554 FC(F)(F)c1cccc(c1)c2cnc(SCc3cccc(Cl)c3)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J17 compound treatment 0.38 0.0235 1.2 0.381 0.0311 1.88 2.1771 0.9768 1908868 Bionet1_001555 FC(F)(F)c1cccc(c1)c2cc(C#N)c(=O)n(Cc3ccc(Cl)cc3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J18 compound treatment 0.373 0.0165 0.84 0.362 0.0121 0.73 1.1129 0.9974 1908869 Bionet1_001556 Fc1ccc(CSc2ncc(cn2)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J19 compound treatment 0.385 0.0285 1.46 0.358 0.0081 0.49 1.3761 0.8953 1908870 Bionet1_001557 COc1ccc(Cn2cc(cc(C#N)c2=O)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J20 compound treatment 0.363 0.0065 0.33 0.369 0.0191 1.15 1.0502 0.8753 1189944 Bionet1_001558 COC(=O)c1c(C(=O)OC)c2CSCn2c1c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J21 compound treatment 0.358 0.0015 0.08 0.348 -0.0019 -0.11 -0.027 -0.1955 1908871 Bionet1_001559 Cc1ccc(Cn2cc(cc(C#N)c2=O)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J22 compound treatment 0.358 0.0015 0.08 0.348 -0.0019 -0.11 -0.027 -0.1955 1735124 Bionet1_001560 COC(=O)c1c(C(=O)OC)c2CS(=O)Cn2c1c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J23 positive control 0.087 -0.27 -13.78 0.087 -0.263 -15.87 -20.9666 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 J24 positive control 0.094 -0.263 -13.42 0.094 -0.256 -15.45 -20.4147 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K01 mock treatment 0.355 -0.0015 -0.08 0.349 -9.03E-4 -0.05 -0.0928 -0.986 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K02 mock treatment 0.363 0.0065 0.33 0.349 -9.03E-4 -0.05 0.1965 0.5833 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K03 compound treatment 0.358 0.0015 0.08 0.337 -0.0129 -0.78 -0.4966 -0.6344 1908872 Bionet1_001561 Cc1cc2n(C)cnc2c(NS(=O)(=O)c3cccc(c3)C(F)(F)F)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K04 compound treatment 0.373 0.0165 0.84 0.349 -9.03E-4 -0.05 0.558 0.66 1908873 Bionet1_001562 FC(F)(F)c1cnc(c(Cl)c1)C(C#N)(N2CCOCC2)c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K05 compound treatment 0.351 -0.0055 -0.28 0.339 -0.0109 -0.66 -0.6643 -0.9281 1412047 Bionet1_001563 Cc1cc2n(C)cnc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K06 compound treatment 0.358 0.0015 0.08 0.353 0.0031 0.19 0.1864 0.9226 1368529 Bionet1_001564 COc1ccc(Cn2cnc3c(NS(=O)(=O)C)c(C)c(C)cc23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K07 compound treatment 0.358 0.0015 0.08 0.344 -0.0059 -0.36 -0.1978 -0.5425 1642363 Bionet1_001565 Cc1cc2n(C)cnc2c(NS(=O)(=O)c3ccccc3Cl)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K08 compound treatment 0.351 -0.0055 -0.28 0.342 -0.0079 -0.48 -0.5362 -0.9682 1908874 Bionet1_001566 FC(F)(F)c1cnc(c(Cl)c1)C(C#N)(N2CCOCC2)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K09 compound treatment 0.345 -0.0115 -0.59 0.33 -0.0199 -1.2 -1.2654 -0.946 1908875 Bionet1_001567 FC(F)(F)c1cccc(c1)c2nnnn2c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K10 compound treatment 0.364 0.0075 0.38 0.349 -9.03E-4 -0.05 0.2326 0.6005 1908876 Bionet1_001568 FC(F)(F)c1cnc(c(Cl)c1)C(C#N)(N2CCOCC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K11 compound treatment 0.345 -0.0115 -0.59 0.343 -0.0069 -0.42 -0.7105 -0.9858 1908877 Bionet1_001569 Brc1ccc(SCCN2C(=O)c3ccccc3C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K12 compound treatment 0.347 -0.0095 -0.49 0.344 -0.0059 -0.36 -0.5955 -0.9884 1908878 Bionet1_001570 Clc1cccc(Cl)c1CON/C=N/OCc2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K13 compound treatment 0.355 -0.0015 -0.08 0.351 0.0011 0.07 -0.0074 -0.0732 1908879 Bionet1_001571 FC(F)(F)c1cccc(c1)n2nnnc2c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K14 compound treatment 0.361 0.0045 0.23 0.352 0.0021 0.13 0.2522 0.9604 1908880 Bionet1_001572 Fc1ccccc1C(C#N)(N2CCOCC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K15 compound treatment 0.351 -0.0055 -0.28 0.353 0.0031 0.19 -0.0667 -0.1974 1172509 Bionet1_001573 Clc1ccc(cc1)S(=O)(=O)CCNC(=O)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K16 compound treatment 0.365 0.0085 0.43 0.358 0.0081 0.49 0.653 0.9983 1908881 Bionet1_001574 COc1ccc(cc1)C(=O)n2cc(cn2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K17 compound treatment 0.345 -0.0115 -0.59 0.345 -0.0049 -0.3 -0.6251 -0.9495 1412820 Bionet1_001575 Cc1ccc(SCC(=O)Nc2ncc3CCc4ccccc4-c3n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K18 compound treatment 0.371 0.0145 0.74 0.362 0.0121 0.73 1.0406 1.0 1908882 Bionet1_001576 CO/N=C/NC(=O)C(c1ccc(F)cc1)c2cccc(c2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K19 compound treatment 0.36 0.0035 0.18 0.347 -0.0029 -0.18 0.0026 0.0104 1908883 Bionet1_001577 Fc1ccc(cc1)C(=O)NCCSc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K20 compound treatment 0.374 0.0175 0.89 0.365 0.0151 0.91 1.2772 1.0 1908884 Bionet1_001578 FC(F)(F)c1cnc(c2cnn(c2)C(=O)c3cccnc3Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K21 compound treatment 0.365 0.0085 0.43 0.344 -0.0059 -0.36 0.0553 0.0985 1908885 Bionet1_001579 Fc1ccc(cc1)C(=O)NCCS(=O)(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K22 compound treatment 0.366 0.0095 0.49 0.346 -0.0039 -0.24 0.1769 0.3276 1908886 Bionet1_001580 FC(F)(F)c1cnc(c(Cl)c1)n2cccc2C(=O)NCc3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K23 positive control 0.091 -0.266 -13.58 0.088 -0.262 -15.81 -20.7793 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 K24 positive control 0.094 -0.263 -13.42 0.095 -0.255 -15.39 -20.372 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L01 mock treatment 0.359 0.0025 0.13 0.35 9.68E-5 0.01 0.0945 0.7387 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L02 mock treatment 0.368 0.0115 0.59 0.351 0.0011 0.07 0.4626 0.7818 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L03 compound treatment 0.371 0.0145 0.74 0.353 0.0031 0.19 0.6565 0.8585 1908887 Bionet1_001581 Fc1ccc(Cn2cc(cc(C#N)c2=O)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L04 compound treatment 0.373 0.0165 0.84 0.355 0.0051 0.31 0.8141 0.9066 1613963 Bionet1_001582 COC(=O)c1c(C(=O)OC)c2CS(=O)(=O)Cn2c1c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L05 compound treatment 0.375 0.0185 0.95 0.365 0.0151 0.91 1.3133 0.9998 1908888 Bionet1_001583 FC(F)(F)c1cccc(c1)c2cc(C#N)c(=O)n(Cc3cccc(Cl)c3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L06 compound treatment 0.395 0.0385 1.97 0.401 0.0511 3.08 3.5732 0.9765 1908889 Bionet1_001584 COc1ccc(Sc2ncccc2c3nc4ccccc4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L07 compound treatment 0.362 0.0055 0.28 0.353 0.0031 0.19 0.331 0.9803 1908890 Bionet1_001585 FC(F)(F)c1cccc(c1)c2cc(C#N)c(=O)n(Cc3ccccc3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L08 compound treatment 0.357 5.0E-4 0.03 0.35 9.68E-5 0.01 0.0222 0.8469 1908891 Bionet1_001586 Clc1ccc(Cn2c(nc3ccccc23)c4ccc(Cl)nc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L09 compound treatment 0.372 0.0155 0.79 0.367 0.0171 1.03 1.2902 0.9915 1908892 Bionet1_001587 FC(F)(F)c1cccc(c1)c2cnc(Oc3ccccc3Cl)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L10 compound treatment 0.367 0.0105 0.54 0.345 -0.0049 -0.3 0.1703 0.2778 1366968 Bionet1_001588 Clc1ccc(Cn2c(nc3ccccc23)c4ccc(Cl)nc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L11 compound treatment 0.383 0.0265 1.36 0.37 0.0201 1.21 1.816 0.9985 1908893 Bionet1_001589 FC(F)(F)c1cccc(c1)c2cnc(Oc3ccc(Cl)cc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L12 compound treatment 0.386 0.0295 1.51 0.364 0.0141 0.85 1.6684 0.9633 1908894 Bionet1_001590 Clc1ccc(cn1)c2nc3ccccc3n2Cc4ccc(Cl)c(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L13 compound treatment 0.382 0.0255 1.3 0.368 0.0181 1.09 1.6945 0.9961 1908895 Bionet1_001591 Fc1ccc(Oc2ncc(cc2C#N)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L14 compound treatment 0.379 0.0225 1.15 0.368 0.0181 1.09 1.586 0.9997 1728237 Bionet1_001592 COC(=O)c1c(C(=O)OC)c2CSCn2c1c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L15 compound treatment 0.362 0.0055 0.28 0.349 -9.03E-4 -0.05 0.1603 0.5596 1908896 Bionet1_001593 Fc1ccc(Oc2ncc(cc2C#N)c3cccc(c3)C(F)(F)F)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L16 compound treatment 0.36 0.0035 0.18 0.353 0.0031 0.19 0.2587 0.9998 1385890 Bionet1_001594 COC(=O)c1c(C(=O)OC)c2CS(=O)Cn2c1c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L17 compound treatment 0.377 0.0205 1.05 0.383 0.0331 2.0 2.154 0.9547 1908897 Bionet1_001595 FC(F)(F)c1cccc(c1)c2cnc(Sc3ccccc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L18 compound treatment 0.362 0.0055 0.28 0.35 9.68E-5 0.01 0.203 0.7216 1226627 Bionet1_001596 COC(=O)c1c(C(=O)OC)c2CS(=O)(=O)Cn2c1c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L19 compound treatment 0.39 0.0335 1.71 0.376 0.0261 1.58 2.3252 0.9991 1908898 Bionet1_001597 FC(F)(F)c1cccc(c1)c2cnc(Sc3cccc(Cl)c3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L20 compound treatment 0.366 0.0095 0.49 0.355 0.0051 0.31 0.561 0.9757 1608690 Bionet1_001598 COC(=O)c1c(C(=O)OC)c2CS(=O)(=O)Cn2c1c3cccc(C)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L21 compound treatment 0.397 0.0405 2.07 0.377 0.0271 1.64 2.621 0.9932 1908899 Bionet1_001599 FC(F)(F)c1cccc(c1)c2cnc(Sc3ccc(Cl)cc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L22 compound treatment 0.358 0.0015 0.08 0.35 9.68E-5 0.01 0.0584 0.7588 1322334 Bionet1_001600 COC(=O)c1c(C(=O)OC)c2CS(=O)Cn2c1c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L23 positive control 0.09 -0.267 -13.63 0.089 -0.261 -15.75 -20.7727 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 L24 positive control 0.094 -0.263 -13.42 0.099 -0.251 -15.15 -20.2012 -0.9982 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M01 mock treatment 0.362 0.0055 0.28 0.351 0.0011 0.07 0.2457 0.8503 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M02 mock treatment 0.357 5.0E-4 0.03 0.353 0.0031 0.19 0.1503 0.7964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M03 compound treatment 0.353 -0.0035 -0.18 0.342 -0.0079 -0.48 -0.4639 -0.9104 1908900 Bionet1_001601 Clc1ccccc1C(=O)NCCSc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M04 compound treatment 0.366 0.0095 0.49 0.35 9.68E-5 0.01 0.3476 0.7156 1908901 Bionet1_001602 FC(F)(F)c1cnc(c(Cl)c1)n2cccc2C(=O)NCc3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M05 compound treatment 0.337 -0.0195 -1.0 0.357 0.0071 0.43 -0.4021 -0.3705 1908902 Bionet1_001603 CO/N=C/C(=N\Nc1ccc(OC)cc1)/C(=O)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M06 compound treatment 0.356 -5.0E-4 -0.03 0.349 -9.03E-4 -0.05 -0.0566 -0.9404 1908903 Bionet1_001604 FC(F)(F)c1cnc(c(Cl)c1)n2cc(cc2C#N)C(=O)Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M07 compound treatment 0.384 0.0275 1.41 0.374 0.0241 1.45 2.0229 0.9999 1908904 Bionet1_001605 CO/N=C/C(=N\Nc1ccc(OC)cc1)/C(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M08 compound treatment 0.359 0.0025 0.13 0.343 -0.0069 -0.42 -0.2043 -0.4687 1908905 Bionet1_001606 FC(F)(F)c1cnc(c(Cl)c1)n2cccc2NC(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M09 compound treatment 0.361 0.0045 0.23 0.354 0.0041 0.25 0.3376 0.9994 1261702 Bionet1_001607 Clc1ccc(SCC(=O)Nc2ncc3CCc4ccccc4-c3n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M10 compound treatment 0.39 0.0335 1.71 0.378 0.0281 1.7 2.4106 1.0 1908906 Bionet1_001608 Nc1nc(Br)c2c(F)cccc2c1c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M11 compound treatment 0.362 0.0055 0.28 0.351 0.0011 0.07 0.2457 0.8503 1908907 Bionet1_001609 CO/N=C/C(=N\Nc1ccc(C)c(C)c1)/C(=O)c2ccc(cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M12 compound treatment 0.383 0.0265 1.36 0.376 0.0261 1.58 2.0721 0.9972 1642271 Bionet1_001610 Nc1nc(Br)c2c(Cl)cccc2c1c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M13 compound treatment 0.397 0.0405 2.07 0.387 0.0371 2.24 3.0479 0.9992 1908908 Bionet1_001611 CO/N=C/C(=N/Nc1ccc(OC)cc1)/C(=O)c2ccc(cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M14 compound treatment 0.353 -0.0035 -0.18 0.344 -0.0059 -0.36 -0.3785 -0.9492 1908909 Bionet1_001612 COc1ccc(NC(=O)c2cccn2c3ncc(cc3Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M15 compound treatment 0.336 -0.0205 -1.05 0.335 -0.0149 -0.9 -1.3774 -0.9971 1256977 Bionet1_001613 OC(CNCc1ccc(Cl)cc1)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M16 compound treatment 0.364 0.0075 0.38 0.359 0.0091 0.55 0.6595 0.9846 1908910 Bionet1_001614 Cc1cc(C)cc(NC(=O)c2cccn2c3ncc(cc3Cl)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M17 compound treatment 0.357 5.0E-4 0.03 0.347 -0.0029 -0.18 -0.1059 -0.5976 1666388 Bionet1_001615 Cc1ccc(CNCC(O)(c2ccc(F)cc2)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M18 compound treatment 0.384 0.0275 1.41 0.373 0.0231 1.39 1.9802 1.0 1908911 Bionet1_001616 FC(F)(F)c1cc(c2ccc(nc2n1)C(C#N)c3ccccc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M19 compound treatment 0.321 -0.0355 -1.82 0.32 -0.0299 -1.81 -2.56 -1.0 1300997 Bionet1_001617 COc1ccc(CNCC(O)(c2ccc(F)cc2)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M20 compound treatment 0.35 -0.0065 -0.33 0.341 -0.0089 -0.54 -0.6151 -0.9733 1146484 Bionet1_001618 NC(=O)C(c1ccc(Cl)cc1)c2ccc(cc2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M21 compound treatment 0.348 -0.0085 -0.43 0.339 -0.0109 -0.66 -0.7728 -0.9797 1701509 Bionet1_001619 COc1ccccc1CNCC(O)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M22 compound treatment 0.354 -0.0025 -0.13 0.346 -0.0039 -0.24 -0.257 -0.9587 1908912 Bionet1_001620 O/N=C/NC(=O)C(c1ccc(Cl)cc1)c2ccc(cc2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M23 positive control 0.09 -0.267 -13.63 0.09 -0.26 -15.69 -20.73 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 M24 positive control 0.095 -0.262 -13.37 0.095 -0.255 -15.39 -20.3358 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N01 mock treatment 0.358 0.0015 0.08 0.344 -0.0059 -0.36 -0.1978 -0.5425 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N02 mock treatment 0.356 -5.0E-4 -0.03 0.352 0.0021 0.13 0.0714 0.5531 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N03 compound treatment 0.358 0.0015 0.08 0.362 0.0121 0.73 0.5706 0.7771 1908913 Bionet1_001621 COc1ccccc1Sc2ncc(cc2C#N)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N04 compound treatment 0.369 0.0125 0.64 0.35 9.68E-5 0.01 0.4561 0.7135 1717312 Bionet1_001622 COC(=O)c1c(C(=O)OC)c2CS(=O)(=O)Cn2c1c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N05 compound treatment 0.458 0.102 5.19 0.446 0.0961 5.8 7.7719 0.9985 1908914 Bionet1_001623 FC(F)(F)c1cc(c2ccc(nc2n1)N3CCC(=O)CC3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N06 compound treatment 0.381 0.0245 1.25 0.369 0.0191 1.15 1.701 0.9991 1520882 Bionet1_001624 COC(=O)c1c(C(=O)OC)c2CSCn2c1c3ccc(cc3)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N07 compound treatment 0.361 0.0045 0.23 0.347 -0.0029 -0.18 0.0388 0.134 1908915 Bionet1_001625 FC(F)(F)c1nnc2c(nc3ccc(Cl)cc3n12)N4CCC(=O)CC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N08 compound treatment 0.365 0.0085 0.43 0.351 0.0011 0.07 0.3541 0.8055 1908916 Bionet1_001626 FC(F)(F)c1cnc(Sc2nc3nccc(c4ccco4)n3n2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N09 compound treatment 0.381 0.0245 1.25 0.378 0.0281 1.7 2.0852 0.9889 1908917 Bionet1_001627 C(O/N=C\1/CCCc2c1cc(c3ccccc3)n2c4ccccc4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N10 compound treatment 0.359 0.0025 0.13 0.356 0.0061 0.37 0.3506 0.9 1908918 Bionet1_001628 COC(=O)c1sccc1OC(C)c2ccnc3nc(nn23)n4cccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N11 compound treatment 0.357 5.0E-4 0.03 0.348 -0.0019 -0.11 -0.0632 -0.5366 1908919 Bionet1_001629 COc1cc(cc(OC)c1OC)C(=O)NCCSc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N12 compound treatment 0.366 0.0095 0.49 0.368 0.0181 1.09 1.116 0.9334 1908920 Bionet1_001630 CC(Oc1ccc(cc1)C(C)(C)C)c2ccnc3nc(/N=C/N(C)C)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N13 compound treatment 0.348 -0.0085 -0.43 0.343 -0.0069 -0.42 -0.602 -0.9998 1908921 Bionet1_001631 COc1cccc(c1)C(=O)NCCSc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N14 compound treatment 0.356 -5.0E-4 -0.03 0.352 0.0021 0.13 0.0714 0.5531 1908922 Bionet1_001632 CC(Oc1ccc(cc1)[N+](=O)[O-])c2ccnc3nc(/N=C/N(C)C)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N15 compound treatment 0.351 -0.0055 -0.28 0.343 -0.0069 -0.42 -0.4935 -0.9817 1345358 Bionet1_001633 O=C1c2ccccc2-c3nnc(cc13)c4ccc(Oc5ccccc5)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N16 compound treatment 0.356 -5.0E-4 -0.03 0.345 -0.0049 -0.3 -0.2274 -0.7653 1908923 Bionet1_001634 CO/N=C/Nc1nc2nccc(C(C)Oc3ccc(cc3)[N+](=O)[O-])n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N17 compound treatment 0.369 0.0125 0.64 0.363 0.0131 0.79 1.011 0.9944 1908924 Bionet1_001635 CN(C)/C=N\c1nc2nccc(c3ccc(Oc4ccccc4)cc3)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N18 compound treatment 0.356 -5.0E-4 -0.03 0.345 -0.0049 -0.3 -0.2274 -0.7653 1908925 Bionet1_001636 CO/N=C/Nc1nc2nccc(C(C)Oc3ccc(Cl)cc3C)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N19 compound treatment 0.358 0.0015 0.08 0.345 -0.0049 -0.3 -0.1551 -0.5071 1908926 Bionet1_001637 CN(C)/C=N/c1nc2ncc(c(\N=C\N(C)C)n2n1)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N20 compound treatment 0.366 0.0095 0.49 0.36 0.0101 0.61 0.7745 0.9937 1908927 Bionet1_001638 CO/N=C/Nc1nc2nccc(C(C)Oc3ccc(cc3)C(C)(C)C)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N21 compound treatment 0.349 -0.0075 -0.38 0.352 0.0021 0.13 -0.1817 -0.4498 1908928 Bionet1_001639 COc1ccc(cc1)c2cnc3nc(/N=C/N(C)C)nn3c2/N=C/N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N22 compound treatment 0.358 0.0015 0.08 0.348 -0.0019 -0.11 -0.027 -0.1955 1908929 Bionet1_001640 CC(Oc1ccc(OC(C)C(=O)/C=C/N(C)C)cc1)C(=O)/C=C/N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N23 positive control 0.105 -0.252 -12.86 0.09 -0.26 -15.69 -20.1877 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 N24 positive control 0.095 -0.262 -13.37 0.095 -0.255 -15.39 -20.3358 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O01 mock treatment 0.357 5.0E-4 0.03 0.358 0.0081 0.49 0.3637 0.7431 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O02 mock treatment 0.356 -5.0E-4 -0.03 0.352 0.0021 0.13 0.0714 0.5531 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O03 compound treatment 0.35 -0.0065 -0.33 0.342 -0.0079 -0.48 -0.5724 -0.9844 1473133 Bionet1_001641 COc1ccc(CNCC(O)(c2ccc(F)cc2)c3ccc(F)cc3)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O04 compound treatment 0.39 0.0335 1.71 0.375 0.0251 1.52 2.2825 0.9981 1233894 Bionet1_001642 Clc1ccc(C(C#N)c2ccc(cc2)C(=O)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O05 compound treatment 0.34 -0.0165 -0.84 0.342 -0.0079 -0.48 -0.9339 -0.9636 1344327 Bionet1_001643 OC(CNCc1ccc(F)cc1)(c2ccc(F)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O06 compound treatment 0.353 -0.0035 -0.18 0.356 0.0061 0.37 0.1337 0.3267 1677560 Bionet1_001644 NC(=O)C(c1ccc(cc1)C(=O)c2ccccc2)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O07 compound treatment 0.351 -0.0055 -0.28 0.333 -0.0169 -1.02 -0.9204 -0.8696 1580259 Bionet1_001645 OC(CNCc1ccc(Cl)cc1)(c2ccccc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O08 compound treatment 0.352 -0.0045 -0.23 0.348 -0.0019 -0.11 -0.2439 -0.9485 1908930 Bionet1_001646 FC(F)(F)c1cnc(c(Cl)c1)C2(CCC(=O)NC2=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O09 compound treatment 0.347 -0.0095 -0.49 0.342 -0.0079 -0.48 -0.6808 -1.0 1644110 Bionet1_001647 COc1ccc(CNCC(O)(c2ccccc2)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O10 compound treatment 0.36 0.0035 0.18 0.358 0.0081 0.49 0.4722 0.9071 1207820 Bionet1_001648 Fc1ccc(cc1)C(=O)c2ccc(cc2)C(C#N)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O11 compound treatment 0.356 -5.0E-4 -0.03 0.347 -0.0029 -0.18 -0.142 -0.8018 1489678 Bionet1_001649 OC(CNCc1ccc(Cl)cc1Cl)(c2ccccc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O12 compound treatment 0.377 0.0205 1.05 0.371 0.0211 1.27 1.6418 0.9953 1517547 Bionet1_001650 Fc1ccc(cc1)C(=O)c2ccc(cc2)C(C#N)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O13 compound treatment 0.35 -0.0065 -0.33 0.339 -0.0109 -0.66 -0.7004 -0.9499 1132342 Bionet1_001651 OC(CNCc1ccc(Cl)c(Cl)c1)(c2ccccc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O14 compound treatment 0.354 -0.0025 -0.13 0.342 -0.0079 -0.48 -0.4278 -0.866 1286508 Bionet1_001652 NC(=O)C(c1ccc(Br)cc1)c2ccc(cc2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O15 compound treatment 0.349 -0.0075 -0.38 0.346 -0.0039 -0.24 -0.4378 -0.9726 1175998 Bionet1_001653 COc1ccccc1CNCC(O)(c2ccccc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O16 compound treatment 0.371 0.0145 0.74 0.367 0.0171 1.03 1.2541 0.9868 1908931 Bionet1_001654 Fc1ccc(cc1)C(=O)c2ccc(cc2)C(C#N)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O17 compound treatment 0.361 0.0045 0.23 0.349 -9.03E-4 -0.05 0.1241 0.525 1174626 Bionet1_001655 CC1N(C(=O)c2ccc(F)cc2)c3ccccc3N(Cc4ccc(C#N)cc4)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O18 compound treatment 0.35 -0.0065 -0.33 0.352 0.0021 0.13 -0.1455 -0.4091 1359301 Bionet1_001656 Cc1onc(c1NC(=O)Nc2c(C)onc2c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O19 compound treatment 0.359 0.0025 0.13 0.348 -0.0019 -0.11 0.0091 0.0532 1656400 Bionet1_001657 CC1N(C(=O)c2ccc(F)cc2)c3ccccc3N(Cc4ccccc4F)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O20 compound treatment 0.363 0.0065 0.33 0.362 0.0121 0.73 0.7514 0.9365 1908932 Bionet1_001658 Cc1nn(C)c(Sc2ccc(Cl)cc2)c1C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O21 compound treatment 0.351 -0.0055 -0.28 0.357 0.0071 0.43 0.1041 0.2031 1908933 Bionet1_001659 CC1N(C(=O)C2CC2)c3ccccc3N(Cc4ccc(cc4)[N+](=O)[O-])C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O22 compound treatment 0.38 0.0235 1.2 0.366 0.0161 0.97 1.5368 0.9945 1256882 Bionet1_001660 Cc1nn(C)c(Oc2ccc(Cl)cc2)c1C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O23 positive control 0.088 -0.269 -13.73 0.09 -0.26 -15.69 -20.8024 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 O24 positive control 0.096 -0.261 -13.32 0.093 -0.257 -15.51 -20.385 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P01 mock treatment 0.358 0.0015 0.08 0.356 0.0061 0.37 0.3145 0.8365 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P02 mock treatment 0.363 0.0065 0.33 0.349 -9.03E-4 -0.05 0.1965 0.5833 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P03 compound treatment 0.369 0.0125 0.64 0.349 -9.03E-4 -0.05 0.4134 0.6444 1908934 Bionet1_001661 CO/N=C/Nc1nc2nccc(c3ccc(Oc4ccccc4)cc3)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P04 compound treatment 0.338 -0.0185 -0.95 0.347 -0.0029 -0.18 -0.7928 -0.8241 1908935 Bionet1_001662 CCNC(=O)Nc1ccccc1Sc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P05 compound treatment 0.359 0.0025 0.13 0.349 -9.03E-4 -0.05 0.0518 0.373 1313795 Bionet1_001663 Cc1ccc(cc1)c2cc(C#N)c(=O)n(Cc3c(Cl)cccc3Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P06 compound treatment 0.341 -0.0155 -0.79 0.345 -0.0049 -0.3 -0.7697 -0.9098 1908936 Bionet1_001664 O=C(c1ccccc1)c2ccc(cc2)C3(CCC(=O)NC3=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P07 compound treatment 0.365 0.0085 0.43 0.355 0.0051 0.31 0.5249 0.9857 1587719 Bionet1_001665 Cc1ccc(cc1)c2cc(C#N)c(=O)n(Cc3ccc(Cl)c(Cl)c3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P08 compound treatment 0.356 -5.0E-4 -0.03 0.351 0.0011 0.07 0.0287 0.4049 1406062 Bionet1_001666 Fc1ccc(Cn2cc(ccc2=O)C(=O)Nc3ccc(Cl)cc3)cc1F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P09 compound treatment 0.36 0.0035 0.18 0.366 0.0161 0.97 0.8137 0.8235 1908937 Bionet1_001667 Cc1ccc(cc1)c2cc(C#N)c(=O)n(Cc3cccc(c3)C(F)(F)F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P10 compound treatment 0.344 -0.0125 -0.64 0.344 -0.0059 -0.36 -0.7039 -0.9619 1693527 Bionet1_001668 Cc1ccc(NC(=O)c2ccc(=O)n(Cc3ccc(F)c(F)c3)c2)cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P11 compound treatment 0.352 -0.0045 -0.23 0.356 0.0061 0.37 0.0976 0.2247 1181820 Bionet1_001669 CN(C)C(=O)Oc1c(C)cc(cc1C)C(=O)CSc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P12 compound treatment 0.368 0.0115 0.59 0.363 0.0131 0.79 0.9749 0.9894 1170430 Bionet1_001670 COC(=O)c1ccccc1NC(=O)c2ccc(=O)n(Cc3ccc(F)c(F)c3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P13 compound treatment 0.373 0.0165 0.84 0.367 0.0171 1.03 1.3264 0.995 1414407 Bionet1_001671 CN(C)C(=S)Oc1c(C)cc(cc1C)C(=O)CSc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P14 compound treatment 0.355 -0.0015 -0.08 0.353 0.0031 0.19 0.078 0.3858 1908938 Bionet1_001672 COC(=O)c1cccn(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P15 compound treatment 0.352 -0.0045 -0.23 0.344 -0.0059 -0.36 -0.4147 -0.9776 1908939 Bionet1_001673 Cc1cc(cc(C)c1O)C(=O)CS(=O)(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P16 compound treatment 0.36 0.0035 0.18 0.364 0.0141 0.85 0.7283 0.8375 1908940 Bionet1_001674 CN(C(=O)c1cccn(Cc2ccc(cc2)C(F)(F)F)c1=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P17 compound treatment 0.388 0.0315 1.61 0.381 0.0311 1.88 2.4663 0.9971 1908941 Bionet1_001675 Cc1cc(cc(C)c1O)C(=O)CS(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P18 compound treatment 0.367 0.0105 0.54 0.346 -0.0039 -0.24 0.213 0.3633 1908942 Bionet1_001676 FC(F)(F)c1ccc(Cn2cccc(C(=O)Nc3ccccc3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P19 compound treatment 0.35 -0.0065 -0.33 0.365 0.0151 0.91 0.4094 0.422 1908943 Bionet1_001677 Clc1ccc(cc1)c2cnc(SCc3ccc(Cl)c(Cl)c3)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P20 compound treatment 0.358 0.0015 0.08 0.356 0.0061 0.37 0.3145 0.8365 1908944 Bionet1_001678 CNC(=O)c1cccn(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P21 compound treatment 0.349 -0.0075 -0.38 0.348 -0.0019 -0.11 -0.3524 -0.8803 1908945 Bionet1_001679 FC(F)(F)c1cccc(CSc2ncc(cn2)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P22 compound treatment 0.36 0.0035 0.18 0.345 -0.0049 -0.3 -0.0828 -0.2393 1908946 Bionet1_001680 CN1CCN(CC1)C(=O)c2cccn(Cc3ccc(cc3)C(F)(F)F)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P23 positive control 0.09 -0.267 -13.63 0.091 -0.259 -15.63 -20.6874 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.572 P24 positive control 0.095 -0.262 -13.37 0.096 -0.254 -15.33 -20.2931 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A01 mock treatment 0.316 -0.0333 -1.7 0.324 -0.0316 -1.91 -2.5516 -0.9983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A02 mock treatment 0.319 -0.0302 -1.55 0.326 -0.0296 -1.79 -2.3578 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A03 compound treatment 0.326 -0.0233 -1.19 0.324 -0.0316 -1.91 -2.1901 -0.9741 1908947 Bionet1_001681 FC(F)(F)c1ccc(Cn2cccc(C(=O)N3CCOCC3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A04 compound treatment 0.332 -0.0173 -0.88 0.342 -0.0136 -0.82 -1.2048 -0.9994 1908948 Bionet1_001682 Nc1ccc(Oc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A05 compound treatment 0.327 -0.0222 -1.14 0.328 -0.0276 -1.67 -1.9832 -0.9827 1908949 Bionet1_001683 FC(F)(F)c1ccc(Cn2cccc(C(=O)NCc3ccccc3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A06 compound treatment 0.318 -0.0313 -1.6 0.324 -0.0316 -1.91 -2.4793 -0.9961 1908950 Bionet1_001684 CO/N=C\Cc1snc(Sc2ncc(cc2Cl)C(F)(F)F)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A07 compound treatment 0.327 -0.0222 -1.14 0.336 -0.0196 -1.18 -1.6417 -0.9998 1908951 Bionet1_001685 FC(F)(F)c1ccc(Cn2cccc(C(=O)Nc3cccnc3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A08 compound treatment 0.318 -0.0313 -1.6 0.328 -0.0276 -1.67 -2.3086 -0.9998 1229496 Bionet1_001686 Clc1ccc(cc1)S(=O)(=O)Nc2ccc(Oc3ncccn3)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A09 compound treatment 0.315 -0.0343 -1.75 0.32 -0.0356 -2.15 -2.7585 -0.9948 1908952 Bionet1_001687 FC(F)(F)c1ccc(Cn2cc(ccc2=O)C(=O)Nc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A10 compound treatment 0.317 -0.0323 -1.65 0.323 -0.0326 -1.97 -2.5582 -0.9961 1715222 Bionet1_001688 Fc1ccc(cc1)S(=O)(=O)Nc2ccc(Oc3ncccn3)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A11 compound treatment 0.322 -0.0273 -1.39 0.324 -0.0316 -1.91 -2.3347 -0.9881 1318775 Bionet1_001689 CCCSc1cc(=O)n(nc1C(=O)Nc2cccc(Cl)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A12 compound treatment 0.319 -0.0302 -1.55 0.33 -0.0256 -1.55 -2.1871 -1.0 1908953 Bionet1_001690 FC(F)(F)c1cccc(c1)C(=O)Nc2ccc(Oc3ncccn3)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A13 compound treatment 0.319 -0.0302 -1.55 0.331 -0.0246 -1.49 -2.1444 -0.9998 1693496 Bionet1_001691 CCCSc1cc(=O)n(nc1C(=O)Nc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A14 compound treatment 0.325 -0.0243 -1.24 0.327 -0.0286 -1.73 -2.0982 -0.9868 1908954 Bionet1_001692 CC(C)NC(=O)c1cnc(Sc2ncc(cc2Cl)C(F)(F)F)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A15 compound treatment 0.325 -0.0243 -1.24 0.325 -0.0306 -1.85 -2.1836 -0.9812 1908955 Bionet1_001693 NC(=O)c1ccc(n(Cc2ccc(Cl)c(Cl)c2)c1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A16 compound treatment 0.322 -0.0273 -1.39 0.329 -0.0266 -1.61 -2.1213 -0.9975 1908956 Bionet1_001694 CCCNC(=O)c1cnc(Sc2ncc(cc2Cl)C(F)(F)F)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A17 compound treatment 0.319 -0.0302 -1.55 0.324 -0.0316 -1.91 -2.4432 -0.9946 1908957 Bionet1_001695 NC(=O)c1ccc(n(Cc2ccc(cc2)C(F)(F)F)c1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A18 compound treatment 0.316 -0.0333 -1.7 0.318 -0.0376 -2.27 -2.8078 -0.9898 1908958 Bionet1_001696 COC(=O)c1cnc(Sc2ncc(cc2Cl)C(F)(F)F)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A19 compound treatment 0.314 -0.0352 -1.8 0.326 -0.0296 -1.79 -2.5386 -1.0 1908959 Bionet1_001697 Cc1ccc(NC(=O)c2cccn(Cc3ccc(cc3)C(F)(F)F)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A20 compound treatment 0.317 -0.0323 -1.65 0.32 -0.0356 -2.15 -2.6862 -0.9914 1908960 Bionet1_001698 CC(c1nnc(S)n1c2ccccc2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A21 compound treatment 0.32 -0.0293 -1.5 0.318 -0.0376 -2.27 -2.6631 -0.9795 1908961 Bionet1_001699 NC(=O)c1ccc(n(Cc2cccc(c2)C(F)(F)F)c1=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A22 compound treatment 0.323 -0.0262 -1.34 0.334 -0.0216 -1.3 -1.8717 -0.9999 1908962 Bionet1_001700 CSc1nnc(C(C)c2ncc(cc2Cl)C(F)(F)F)n1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A23 positive control 0.086 -0.263 -13.46 0.087 -0.269 -16.22 -20.9843 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 A24 positive control 0.089 -0.26 -13.31 0.094 -0.262 -15.79 -20.577 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B01 mock treatment 0.353 0.00375 0.19 0.35 -0.00561 -0.34 -0.104 -0.2672 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B02 mock treatment 0.359 0.00975 0.5 0.359 0.00339 0.2 0.4971 0.9225 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B03 compound treatment 0.349 -2.5E-4 -0.01 0.36 0.00439 0.26 0.1782 0.6722 1734321 Bionet1_001701 CC(O)(CS(=O)(=O)Cc1ccc(Cl)cc1Cl)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B04 compound treatment 0.357 0.00775 0.4 0.359 0.00339 0.2 0.4248 0.9526 1908963 Bionet1_001702 COc1ccc(cc1)c2cc(n[nH]2)C3CCN(Cc4ccc(cc4)[N+](=O)[O-])CC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B05 compound treatment 0.344 -0.00525 -0.27 0.356 3.87E-4 0.02 -0.1733 -0.6431 1408080 Bionet1_001703 CC(O)(CS(=O)(=O)Cc1ccc(Cl)cc1Cl)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B06 compound treatment 0.349 -2.5E-4 -0.01 0.354 -0.00161 -0.1 -0.0779 -0.7931 1908964 Bionet1_001704 [O-][N+](=O)c1ccc(CN2CCC(CC2)c3cc([nH]n3)c4ccco4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B07 compound treatment 0.351 0.00175 0.09 0.355 -6.13E-4 -0.04 0.0371 0.3833 1248384 Bionet1_001705 CC(O)(CS(=O)(=O)Cc1ccccc1)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B08 compound treatment 0.35 7.5E-4 0.04 0.361 0.00539 0.33 0.2571 0.7851 1583003 Bionet1_001706 Cc1ccc(cc1)S(=O)(=O)N2CCC(CC2)c3cc([nH]n3)c4ccco4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B09 compound treatment 0.346 -0.00325 -0.17 0.352 -0.00361 -0.22 -0.2717 -0.991 1312341 Bionet1_001707 CC(O)(CS(=O)(=O)Cc1ccc(Cl)cc1)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B10 compound treatment 0.346 -0.00325 -0.17 0.35 -0.00561 -0.34 -0.3571 -0.9462 1677585 Bionet1_001708 Clc1cccc(NC(=O)N2CCC(CC2)c3cc([nH]n3)c4ccco4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B11 compound treatment 0.354 0.00475 0.24 0.352 -0.00361 -0.22 0.0175 0.0537 1251378 Bionet1_001709 CC(O)(CS(=O)(=O)Cc1ccc(Cl)cc1)c2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B12 compound treatment 0.364 0.0147 0.75 0.369 0.0134 0.81 1.1048 0.9994 1908965 Bionet1_001710 N(/N=C(\C(=N/Nc1ccccc1)\c2ccccc2)/c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B13 compound treatment 0.352 0.00275 0.14 0.357 0.00139 0.08 0.1586 0.9693 1430279 Bionet1_001711 COc1ccc(CS(=O)(=O)CC(C)(O)c2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B14 compound treatment 0.344 -0.00525 -0.27 0.362 0.00639 0.39 0.0828 0.1763 1908966 Bionet1_001712 CCOC(=O)C1=NOC(CNC(=O)C2CCN(CC2)c3ncccn3)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B15 compound treatment 0.349 -2.5E-4 -0.01 0.361 0.00539 0.33 0.2209 0.6788 1619236 Bionet1_001713 CC(O)(CS(=O)(=O)Cc1ccccc1Cl)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B16 compound treatment 0.358 0.00875 0.45 0.362 0.00639 0.39 0.589 0.9973 1908967 Bionet1_001714 FC(F)(F)c1cnc(Sc2nccn2c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B17 compound treatment 0.351 0.00175 0.09 0.366 0.0104 0.63 0.5067 0.7999 1654437 Bionet1_001715 COC(=O)c1cccnc1N2CCN(CC2)C(c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B18 compound treatment 0.361 0.0118 0.6 0.367 0.0114 0.69 0.9109 0.9977 1908968 Bionet1_001716 CN(NC(=S)NC(=O)c1ccccc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B19 compound treatment 0.359 0.00975 0.5 0.362 0.00639 0.39 0.6252 0.9919 1908969 Bionet1_001717 COC(=O)c1ccccc1Sc2c(CO)c(nn2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B20 compound treatment 0.359 0.00975 0.5 0.358 0.00239 0.14 0.4544 0.8757 1377112 Bionet1_001718 COc1ccc(cc1)C(=O)N2CCOC32CCN(CC3)c4ccc(Cl)nn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B21 compound treatment 0.359 0.00975 0.5 0.36 0.00439 0.26 0.5398 0.9562 1412512 Bionet1_001719 Clc1ccc(CSc2nc(c([nH]2)c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B22 compound treatment 0.354 0.00475 0.24 0.356 3.87E-4 0.02 0.1883 0.7716 1908970 Bionet1_001720 CC(=O)C1=NOC(CNC(=O)c2c(C)onc2c3ccccc3Cl)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B23 positive control 0.086 -0.263 -13.46 0.089 -0.267 -16.09 -20.8989 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 B24 positive control 0.088 -0.261 -13.36 0.092 -0.264 -15.91 -20.6986 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C01 mock treatment 0.354 0.00475 0.24 0.352 -0.00361 -0.22 0.0175 0.0537 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C02 mock treatment 0.361 0.0118 0.6 0.36 0.00439 0.26 0.6121 0.9323 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C03 compound treatment 0.353 0.00375 0.19 0.357 0.00139 0.08 0.1948 0.931 1908971 Bionet1_001721 CN(C)C(=O)c1cc(Cl)cn(Cc2ccc(cc2)C(F)(F)F)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C04 compound treatment 0.354 0.00475 0.24 0.367 0.0114 0.69 0.6578 0.9023 1908972 Bionet1_001722 CC(c1nnc(SCC=C)n1C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C05 compound treatment 0.355 0.00575 0.29 0.358 0.00239 0.14 0.3098 0.9461 1707687 Bionet1_001723 Cc1cc2nc(c3ccc(Cl)nc3)n(Cc4ccc(Cl)cc4)c2cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C06 compound treatment 0.34 -0.00925 -0.47 0.362 0.00639 0.39 -0.0618 -0.1013 1908973 Bionet1_001724 Sc1nnc(CSCc2c(Cl)cccc2Cl)n1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C07 compound treatment 0.355 0.00575 0.29 0.357 0.00139 0.08 0.2671 0.8738 1250698 Bionet1_001725 COc1ccc(Cn2c(nc3cc(C)c(C)cc23)c4ccc(Cl)nc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C08 compound treatment 0.349 -2.5E-4 -0.01 0.359 0.00339 0.2 0.1355 0.6616 1292960 Bionet1_001726 CC(C)(C)c1ccc(COc2ccsc2C(=O)Nc3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C09 compound treatment 0.35 7.5E-4 0.04 0.354 -0.00161 -0.1 -0.0417 -0.3988 1385613 Bionet1_001727 Cc1ccc(Cn2c(nc3cc(C)c(C)cc23)c4ccc(Cl)nc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C10 compound treatment 0.351 0.00175 0.09 0.354 -0.00161 -0.1 -0.0056 -0.0422 1908974 Bionet1_001728 CCn1c(S)nnc1CS(=O)Cc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C11 compound treatment 0.347 -0.00225 -0.12 0.35 -0.00561 -0.34 -0.3209 -0.8969 1908975 Bionet1_001729 CCOC(=O)Cn1c(nc2cc(Cl)c(Cl)cc12)c3cccnc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C12 compound treatment 0.342 -0.00725 -0.37 0.345 -0.0106 -0.64 -0.7152 -0.9662 1908976 Bionet1_001730 Sc1nnc(CSCc2ccc(Cl)cc2Cl)n1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C13 compound treatment 0.346 -0.00325 -0.17 0.343 -0.0126 -0.76 -0.6559 -0.8416 1908977 Bionet1_001731 FC(F)(F)c1cccc(Cn2nnnc2c3cc(Cl)cc(Cl)c3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C14 compound treatment 0.35 7.5E-4 0.04 0.352 -0.00361 -0.22 -0.1271 -0.574 1908978 Bionet1_001732 CSc1nnc(CSCc2ccc(Cl)cc2Cl)n1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C15 compound treatment 0.349 -2.5E-4 -0.01 0.356 3.87E-4 0.02 0.0075 0.281 1282281 Bionet1_001733 Cc1c(oc2c(Br)cc(Br)cc12)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C16 compound treatment 0.349 -2.5E-4 -0.01 0.358 0.00239 0.14 0.0929 0.6419 1908979 Bionet1_001734 CCn1c(S)nnc1CS(=O)Cc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C17 compound treatment 0.35 7.5E-4 0.04 0.357 0.00139 0.08 0.0863 0.9373 1182767 Bionet1_001735 Cc1c(oc2ccc(Br)cc12)C(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C18 compound treatment 0.353 0.00375 0.19 0.363 0.00739 0.45 0.4509 0.9289 1242855 Bionet1_001736 COc1ccc(COc2ccsc2C(=O)Nc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C19 compound treatment 0.35 7.5E-4 0.04 0.356 3.87E-4 0.02 0.0436 0.9718 1346812 Bionet1_001737 Cc1c(oc2ccc(Br)cc12)C(=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C20 compound treatment 0.36 0.0107 0.55 0.359 0.00339 0.2 0.5333 0.9093 1222750 Bionet1_001738 Oc1cc(nc(=O)n1Cc2ccccc2)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C21 compound treatment 0.352 0.00275 0.14 0.355 -6.13E-4 -0.04 0.0733 0.5039 1092671 Bionet1_001739 COC(=O)c1c(C(=O)OC)c2CCCn2c1c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C22 compound treatment 0.359 0.00975 0.5 0.358 0.00239 0.14 0.4544 0.8757 1549187 Bionet1_001740 Oc1cc(nc(=O)n1Cc2ccccc2)C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C23 positive control 0.085 -0.264 -13.51 0.089 -0.267 -16.09 -20.9351 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 C24 positive control 0.087 -0.262 -13.41 0.096 -0.26 -15.67 -20.564 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D01 mock treatment 0.34 -0.00925 -0.47 0.344 -0.0116 -0.7 -0.8302 -0.9816 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D02 mock treatment 0.352 0.00275 0.14 0.351 -0.00461 -0.28 -0.0975 -0.3125 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D03 compound treatment 0.331 -0.0182 -0.93 0.348 -0.00761 -0.46 -0.9848 -0.9468 1716876 Bionet1_001741 Cn1c(SCc2ccccc2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D04 compound treatment 0.345 -0.00425 -0.22 0.337 -0.0186 -1.12 -0.9482 -0.8285 1908980 Bionet1_001742 CCOC(=O)/C=C(\C)/NCCNc1ncc(cc1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D05 compound treatment 0.352 0.00275 0.14 0.347 -0.00861 -0.52 -0.2682 -0.498 1382998 Bionet1_001743 CCCn1c(SCc2ccccc2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D06 compound treatment 0.345 -0.00425 -0.22 0.353 -0.00261 -0.16 -0.2652 -0.9876 1908981 Bionet1_001744 Cc1ccc(cc1)c2nnc(C)c(Sc3c(Cl)cccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D07 compound treatment 0.429 0.0798 4.08 0.365 0.00939 0.57 3.2841 0.7977 1331294 Bionet1_001745 C=CCn1c(SCc2ccccc2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D08 compound treatment 0.343 -0.00625 -0.32 0.351 -0.00461 -0.28 -0.4229 -0.9976 1908982 Bionet1_001746 Cc1ccc(cc1)c2nnc(C)c(Sc3cccc(c3)C(F)(F)F)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D09 compound treatment 0.364 0.0147 0.75 0.372 0.0164 0.99 1.2328 0.991 1182579 Bionet1_001747 C#CCn1c(SCc2ccccc2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D10 compound treatment 0.34 -0.00925 -0.47 0.347 -0.00861 -0.52 -0.7021 -0.9989 1345564 Bionet1_001748 CCOC(=O)n1c(=O)n(Cc2ccc(Cl)cc2Cl)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D11 compound treatment 0.341 -0.00825 -0.42 0.352 -0.00361 -0.22 -0.4525 -0.9529 1908983 Bionet1_001749 Cn1nc(c(COC(=O)c2ccc(Cl)c(Cl)c2)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D12 compound treatment 0.34 -0.00925 -0.47 0.347 -0.00861 -0.52 -0.7021 -0.9989 1494248 Bionet1_001750 CCOC(=O)n1c(=O)n(Cc2ccc(Cl)c(Cl)c2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D13 compound treatment 0.347 -0.00225 -0.12 0.354 -0.00161 -0.1 -0.1502 -0.9966 1908984 Bionet1_001751 Cn1nc(c(COC(=O)c2ccc(Cl)cc2Cl)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D14 compound treatment 0.341 -0.00825 -0.42 0.343 -0.0126 -0.76 -0.8367 -0.9612 1238936 Bionet1_001752 CCOC(=O)n1c(=O)n(Cc2c(Cl)cccc2Cl)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D15 compound treatment 0.351 0.00175 0.09 0.347 -0.00861 -0.52 -0.3044 -0.5769 1908985 Bionet1_001753 Cn1nc(c(COC(=O)c2ccc(cc2)[N+](=O)[O-])c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D16 compound treatment 0.345 -0.00425 -0.22 0.351 -0.00461 -0.28 -0.3506 -0.9925 1908986 Bionet1_001754 CS(=O)(=O)c1ccccc1c2nnc(o2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D17 compound treatment 0.344 -0.00525 -0.27 0.344 -0.0116 -0.7 -0.6855 -0.9132 1908987 Bionet1_001755 Cn1c(SCc2ccc(Cl)cc2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D18 compound treatment 0.347 -0.00225 -0.12 0.349 -0.00661 -0.4 -0.3636 -0.8753 1908988 Bionet1_001756 Clc1ccc(CSc2ccccc2c3nnc(o3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D19 compound treatment 0.344 -0.00525 -0.27 0.349 -0.00661 -0.4 -0.4721 -0.9814 1908989 Bionet1_001757 Cn1nc(c(CO)c1Sc2ccc(Br)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D20 compound treatment 0.347 -0.00225 -0.12 0.355 -6.13E-4 -0.04 -0.1075 -0.8896 1908990 Bionet1_001758 Cc1ccc(cc1)c2nnc(o2)c3ccccc3SCc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D21 compound treatment 0.351 0.00175 0.09 0.35 -0.00561 -0.34 -0.1763 -0.5031 1908991 Bionet1_001759 Cc1ccc(Oc2c(COC(=O)CCl)c(nn2C)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D22 compound treatment 0.347 -0.00225 -0.12 0.355 -6.13E-4 -0.04 -0.1075 -0.8896 1908992 Bionet1_001760 O=S(=O)(Cc1ccccc1)c2ccccc2c3nnc(o3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D23 positive control 0.086 -0.263 -13.46 0.088 -0.268 -16.16 -20.9416 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 D24 positive control 0.091 -0.258 -13.2 0.098 -0.258 -15.55 -20.334 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E01 mock treatment 0.35 7.5E-4 0.04 0.354 -0.00161 -0.1 -0.0417 -0.3988 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E02 mock treatment 0.362 0.0127 0.65 0.355 -6.13E-4 -0.04 0.4348 0.6659 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E03 compound treatment 0.354 0.00475 0.24 0.366 0.0104 0.63 0.6151 0.9148 1908993 Bionet1_001761 COC(=O)c1c(C(=O)OC)c2CCCn2c1c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E04 compound treatment 0.339 -0.0103 -0.52 0.346 -0.00961 -0.58 -0.7809 -0.9987 1375946 Bionet1_001762 Oc1cc(nc(=O)n1Cc2ccccc2)C(=O)Nc3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E05 compound treatment 0.349 -2.5E-4 -0.01 0.352 -0.00361 -0.22 -0.1633 -0.7473 1908994 Bionet1_001763 Cc1ccn2c(=O)nc(SCc3cccc(c3)C(F)(F)F)nc2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E06 compound treatment 0.372 0.0227 1.16 0.386 0.0304 1.83 2.1197 0.9758 1534835 Bionet1_001764 Oc1cc(nc(=O)n1Cc2ccccc2)C(=O)Nc3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E07 compound treatment 0.352 0.00275 0.14 0.367 0.0114 0.69 0.5855 0.8345 1908995 Bionet1_001765 CN(C)/C=N/c1nc(N2CCN(CC2)c3ccccn3)c(C#N)cc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E08 compound treatment 0.357 0.00775 0.4 0.376 0.0204 1.23 1.1505 0.8898 1515561 Bionet1_001766 Oc1cc(nc(=O)n1Cc2ccccc2)C(=O)Nc3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E09 compound treatment 0.349 -2.5E-4 -0.01 0.363 0.00739 0.45 0.3063 0.6866 1908996 Bionet1_001767 CC1=C(CC(=O)c2sccc2Br)C(=O)c3ccccc3C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E10 compound treatment 0.352 0.00275 0.14 0.361 0.00539 0.33 0.3294 0.9297 1908997 Bionet1_001768 Oc1cc(nc(=O)n1Cc2ccccc2)C(=O)Nc3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E11 compound treatment 0.328 -0.0213 -1.09 0.345 -0.0106 -0.64 -1.2213 -0.9683 1908998 Bionet1_001769 Clc1cccc(CNCCNCc2cccc(Cl)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E12 compound treatment 0.351 0.00175 0.09 0.37 0.0144 0.87 0.6774 0.7759 1908999 Bionet1_001770 Oc1cc(nc(=O)n1Cc2ccccc2)C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E13 compound treatment 0.337 -0.0123 -0.63 0.35 -0.00561 -0.34 -0.6825 -0.9584 1909000 Bionet1_001771 FC(F)(F)c1cccc(Sc2nc3ccccc3nc2C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E14 compound treatment 0.341 -0.00825 -0.42 0.349 -0.00661 -0.4 -0.5806 -0.9996 1488811 Bionet1_001772 OC(CSc1ccc(Cl)cc1)CN2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E15 compound treatment 0.338 -0.0113 -0.58 0.357 0.00139 0.08 -0.3475 -0.5979 1909001 Bionet1_001773 CC(C)NS(=O)(=O)c1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E16 compound treatment 0.351 0.00175 0.09 0.356 3.87E-4 0.02 0.0798 0.8628 1909002 Bionet1_001774 OC(CSc1cccc(c1)C(F)(F)F)CN2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E17 compound treatment 0.35 7.5E-4 0.04 0.36 0.00439 0.26 0.2144 0.8011 1909003 Bionet1_001775 CCCNS(=O)(=O)c1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E18 compound treatment 0.343 -0.00625 -0.32 0.353 -0.00261 -0.16 -0.3375 -0.947 1375708 Bionet1_001776 OC(CSc1cccc(Cl)c1)CN2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E19 compound treatment 0.348 -0.00125 -0.06 0.353 -0.00261 -0.16 -0.1567 -0.9209 1909004 Bionet1_001777 N/C(=C(\C=C(C#N)C#N)/C#N)/N1CCN(CC1)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E20 compound treatment 0.357 0.00775 0.4 0.353 -0.00261 -0.16 0.1687 0.3955 1659409 Bionet1_001778 OC(CSc1ccccc1Cl)CN2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E21 compound treatment 0.359 0.00975 0.5 0.359 0.00339 0.2 0.4971 0.9225 1909005 Bionet1_001779 CN(C)/C=N/c1nc(N2CCN(CC2)c3cccc(Cl)n3)c(C#N)cc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E22 compound treatment 0.352 0.00275 0.14 0.359 0.00339 0.2 0.244 0.9833 1477976 Bionet1_001780 OC(CSc1ccc(Cl)cc1)CN2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E23 positive control 0.087 -0.262 -13.41 0.091 -0.265 -15.97 -20.7774 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 E24 positive control 0.092 -0.257 -13.15 0.098 -0.258 -15.55 -20.2978 -0.9965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F01 mock treatment 0.347 -0.00225 -0.12 0.352 -0.00361 -0.22 -0.2356 -0.9553 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F02 mock treatment 0.352 0.00275 0.14 0.359 0.00339 0.2 0.244 0.9833 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F03 compound treatment 0.346 -0.00325 -0.17 0.352 -0.00361 -0.22 -0.2717 -0.991 1909006 Bionet1_001781 Cn1nc(c(CO)c1Sc2cccc(c2)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F04 compound treatment 0.353 0.00375 0.19 0.361 0.00539 0.33 0.3655 0.9683 1909007 Bionet1_001782 Cc1ccc(CSc2ccccc2c3nnc(o3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F05 compound treatment 0.379 0.0297 1.52 0.401 0.0454 2.74 3.0131 0.9614 1909008 Bionet1_001783 Cn1nc(c(COC(=O)Nc2ccc(Cl)cc2)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F06 compound treatment 0.348 -0.00125 -0.06 0.372 0.0164 0.99 0.6543 0.66 1909009 Bionet1_001784 Cc1ccc(CSc2ccccc2c3nnc(o3)c4ccc(C)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F07 compound treatment 0.37 0.0208 1.06 0.398 0.0424 2.56 2.5596 0.924 1909010 Bionet1_001785 CC(C)(C)c1ccc(CSc2nc(c([nH]2)c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F08 compound treatment 0.338 -0.0113 -0.58 0.332 -0.0236 -1.43 -1.4147 -0.9203 1909011 Bionet1_001786 Cc1ccc(CSc2ccccc2c3nnc(o3)c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F09 compound treatment 0.349 -2.5E-4 -0.01 0.345 -0.0106 -0.64 -0.4621 -0.7211 1909012 Bionet1_001787 Cn1nc(c(CO)c1Sc2c(Cl)cccc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F10 compound treatment 0.344 -0.00525 -0.27 0.353 -0.00261 -0.16 -0.3014 -0.9679 1909013 Bionet1_001788 Cc1ccc(CS(=O)c2ccccc2c3nnc(o3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F11 compound treatment 0.348 -0.00125 -0.06 0.361 0.00539 0.33 0.1848 0.5575 1909014 Bionet1_001789 COCc1c(Sc2c(Cl)cccc2Cl)n(C)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F12 compound treatment 0.354 0.00475 0.24 0.346 -0.00961 -0.58 -0.2386 -0.3793 1909015 Bionet1_001790 Cc1ccc(CS(=O)(=O)c2ccccc2c3nnc(o3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F13 compound treatment 0.352 0.00275 0.14 0.354 -0.00161 -0.1 0.0306 0.1788 1909016 Bionet1_001791 Cn1nc(c(COCc2c(Cl)cccc2Cl)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F14 compound treatment 0.353 0.00375 0.19 0.363 0.00739 0.45 0.4509 0.9289 1909017 Bionet1_001792 CNC(=O)c1cnn(c2nc(cs2)c3ccc(Cl)cc3)c1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F15 compound treatment 0.357 0.00775 0.4 0.365 0.00939 0.57 0.6809 0.9847 1909018 Bionet1_001793 CN(C)c1nnnn1c2ccc(Oc3ncc(cc3Cl)C(F)(F)F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F16 compound treatment 0.36 0.0107 0.55 0.365 0.00939 0.57 0.7894 0.9999 1909019 Bionet1_001794 CNC(=O)c1cnn(c2nc(cs2)c3ccccc3)c1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F17 compound treatment 0.372 0.0227 1.16 0.375 0.0194 1.17 1.6501 1.0 1909020 Bionet1_001795 CN(C)c1nnnn1c2cccc(Oc3ncc(cc3Cl)C(F)(F)F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F18 compound treatment 0.386 0.0367 1.88 0.37 0.0144 0.87 1.9429 0.9385 1909021 Bionet1_001796 FC(F)(F)c1c(cnn1c2nc(cs2)c3ccccc3)C(=O)NCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F19 compound treatment 0.337 -0.0123 -0.63 0.36 0.00439 0.26 -0.2556 -0.3759 1909022 Bionet1_001797 CN(C)c1nnnn1c2ccccc2Oc3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F20 compound treatment 0.345 -0.00425 -0.22 0.355 -6.13E-4 -0.04 -0.1798 -0.8158 1909023 Bionet1_001798 COc1ccc(cc1)C(=O)NCCSc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F21 compound treatment 0.369 0.0198 1.01 0.372 0.0164 0.99 1.4136 0.9999 1909024 Bionet1_001799 CN(C)/C=N/c1nnc(s1)\C(=C\c2ccc(Cl)cc2Cl)\C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F22 compound treatment 0.357 0.00775 0.4 0.354 -0.00161 -0.1 0.2114 0.518 1909025 Bionet1_001800 Clc1ccc(SCCNC(=O)c2ccc(Cl)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F23 positive control 0.087 -0.262 -13.41 0.092 -0.264 -15.91 -20.7347 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 F24 positive control 0.095 -0.254 -13.0 0.098 -0.258 -15.55 -20.1894 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G01 mock treatment 0.34 -0.00925 -0.47 0.352 -0.00361 -0.22 -0.4887 -0.9382 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G02 mock treatment 0.35 7.5E-4 0.04 0.352 -0.00361 -0.22 -0.1271 -0.574 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G03 compound treatment 0.346 -0.00325 -0.17 0.349 -0.00661 -0.4 -0.3998 -0.9246 1390729 Bionet1_001801 Cc1c(oc2c(Cl)cc(Cl)cc12)C(=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G04 compound treatment 0.34 -0.00925 -0.47 0.349 -0.00661 -0.4 -0.6167 -0.9964 1288139 Bionet1_001802 OC(CSc1ccc(F)cc1)CN2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G05 compound treatment 0.339 -0.0103 -0.52 0.348 -0.00761 -0.46 -0.6956 -0.9979 1909026 Bionet1_001803 Cc1c(oc2c(Cl)cc(Cl)cc12)C(=O)c3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G06 compound treatment 0.318 -0.0313 -1.6 0.328 -0.0276 -1.67 -2.3086 -0.9998 1650823 Bionet1_001804 OC(CSc1cccc(Cl)c1)CN2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G07 compound treatment 0.342 -0.00725 -0.37 0.349 -0.00661 -0.4 -0.5444 -0.9993 1507563 Bionet1_001805 Cc1cc2nc([nH]c2cc1C)C(Cc3ccccc3)NC(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G08 compound treatment 0.354 0.00475 0.24 0.362 0.00639 0.39 0.4444 0.9752 1693783 Bionet1_001806 Cc1ccc(SCC(O)CN2CCN(CC2)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G09 compound treatment 0.36 0.0107 0.55 0.37 0.0144 0.87 1.0028 0.9756 1214826 Bionet1_001807 COc1cccc(c1)C(=O)NC(Cc2ccccc2)c3nc4ccccc4[nH]3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G10 compound treatment 0.338 -0.0113 -0.58 0.343 -0.0126 -0.76 -0.9452 -0.9904 1304653 Bionet1_001808 Cc1ccc(SCC(O)CN2CCN(CC2)c3ccccc3F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G11 compound treatment 0.356 0.00675 0.35 0.371 0.0154 0.93 0.9009 0.9091 1524482 Bionet1_001809 COc1cccc(c1)C(=O)NC(Cc2ccccc2)c3nc4cc(C)ccc4[nH]3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G12 compound treatment 0.34 -0.00925 -0.47 0.341 -0.0146 -0.88 -0.9582 -0.9573 1469852 Bionet1_001810 OC(CSc1ccc(F)cc1)CN2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G13 compound treatment 0.365 0.0158 0.81 0.364 0.00839 0.51 0.9275 0.975 1650256 Bionet1_001811 Fc1ccccc1C(=O)NC(Cc2ccccc2)c3nc4ccccc4[nH]3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G14 compound treatment 0.338 -0.0113 -0.58 0.343 -0.0126 -0.76 -0.9452 -0.9904 1430519 Bionet1_001812 OC(CSc1ccccc1Cl)CN2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G15 compound treatment 0.361 0.0118 0.6 0.376 0.0204 1.23 1.2951 0.9456 1304217 Bionet1_001813 Cc1cc2nc([nH]c2cc1C)C(Cc3ccccc3)NC(=O)c4ccccc4F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G16 compound treatment 0.344 -0.00525 -0.27 0.354 -0.00161 -0.1 -0.2587 -0.9058 1194683 Bionet1_001814 OC(CSc1ccccc1Cl)CN2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G17 compound treatment 0.352 0.00275 0.14 0.349 -0.00661 -0.4 -0.1829 -0.432 1415859 Bionet1_001815 CC(C)C(NC(=O)c1ccc(Cl)cc1Cl)c2nc3ccccc3[nH]2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G18 compound treatment 0.357 0.00775 0.4 0.347 -0.00861 -0.52 -0.0874 -0.1338 1909027 Bionet1_001816 CCCCSc1nnc(CNS(=O)(=O)c2ccc(Cl)cc2)n1CC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G19 compound treatment 0.355 0.00575 0.29 0.356 3.87E-4 0.02 0.2244 0.7609 1711863 Bionet1_001817 Clc1ccc(Cn2c(nc3ccccc23)c4cccnc4Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G20 compound treatment 0.353 0.00375 0.19 0.357 0.00139 0.08 0.1948 0.931 1909028 Bionet1_001818 CCn1c(CNS(=O)(=O)c2ccc(Cl)cc2)nnc1SCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G21 compound treatment 0.355 0.00575 0.29 0.361 0.00539 0.33 0.4379 0.9987 1909029 Bionet1_001819 Clc1ccc(Cn2c(nc3ccccc23)c4cccnc4Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G22 compound treatment 0.346 -0.00325 -0.17 0.349 -0.00661 -0.4 -0.3998 -0.9246 1409296 Bionet1_001820 OC(CSc1ccc(Cl)cc1)CN2CCN(CC2)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G23 positive control 0.098 -0.251 -12.85 0.09 -0.266 -16.03 -20.4224 -0.994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 G24 positive control 0.1 -0.249 -12.74 0.1 -0.256 -15.43 -19.9232 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H01 mock treatment 0.349 -2.5E-4 -0.01 0.356 3.87E-4 0.02 0.0075 0.281 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H02 mock treatment 0.359 0.00975 0.5 0.356 3.87E-4 0.02 0.369 0.7394 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H03 compound treatment 0.357 0.00775 0.4 0.362 0.00639 0.39 0.5529 0.9999 1909030 Bionet1_001821 CO/N=C/Nc1nnc(s1)/C(=C/c2ccc(Cl)cc2Cl)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H04 compound treatment 0.39 0.0408 2.08 0.396 0.0404 2.44 3.1974 0.9969 1909031 Bionet1_001822 FC(F)(F)c1cccc(c1)c2cc3ccccc3nc2Oc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H05 compound treatment 0.387 0.0377 1.93 0.396 0.0404 2.44 3.0889 0.9933 1909032 Bionet1_001823 COc1ccc(/C=C(\C#N)/c2nnc(\N=C\Nc3ccc(Cl)cc3)s2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H06 compound treatment 0.382 0.0328 1.67 0.393 0.0374 2.26 2.78 0.9892 1909033 Bionet1_001824 FC(F)(F)c1cccc(c1)c2cc3ccccc3nc2Oc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H07 compound treatment 0.347 -0.00225 -0.12 0.365 0.00939 0.57 0.3194 0.5523 1909034 Bionet1_001825 [O-][N+](=O)C(/C=N/OCc1c(F)cccc1Cl)S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H08 compound treatment 0.365 0.0158 0.81 0.358 0.00239 0.14 0.6714 0.8206 1909035 Bionet1_001826 Fc1ccc(Oc2nc3ccccc3cc2c4cccc(c4)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H09 compound treatment 0.454 0.105 5.36 0.469 0.113 6.84 8.6275 0.9926 1909036 Bionet1_001827 Clc1cccc(Cl)c1CSc2nccc(/C=C/c3cccs3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H10 compound treatment 0.412 0.0628 3.21 0.419 0.0634 3.83 4.9746 0.9962 1909037 Bionet1_001828 Cc1cc(C)cc(Oc2nc3ccccc3cc2c4cccc(c4)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H11 compound treatment 0.399 0.0498 2.54 0.403 0.0474 2.86 3.8216 0.9983 1909038 Bionet1_001829 FC(F)(F)c1cnc(Sc2nccc(/C=C/c3cccs3)n2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H12 compound treatment 0.402 0.0527 2.7 0.407 0.0514 3.1 4.1008 0.9976 1909039 Bionet1_001830 COc1ccc(Oc2nc3ccccc3cc2c4cccc(c4)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H13 compound treatment 0.356 0.00675 0.35 0.346 -0.00961 -0.58 -0.1663 -0.2463 1909040 Bionet1_001831 Cc1nc(c(s1)C(=O)NCc2cccc(c2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H14 compound treatment 0.377 0.0278 1.42 0.389 0.0334 2.02 2.4285 0.9852 1508829 Bionet1_001832 Cc1ccc(C)c(SCc2nc3ccccc3c(=O)n2c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H15 compound treatment 0.377 0.0278 1.42 0.382 0.0264 1.59 2.1297 0.9983 1909041 Bionet1_001833 CN(C)/C=C(\C#N)/C(=O)CSc1ncc(cc1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H16 compound treatment 0.355 0.00575 0.29 0.349 -0.00661 -0.4 -0.0744 -0.15 1909042 Bionet1_001834 CCOC(=O)CN(c1ccccc1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H17 compound treatment 0.36 0.0107 0.55 0.359 0.00339 0.2 0.5333 0.9093 1716227 Bionet1_001835 Clc1ccc(cc1)c2onc3ccc(cc23)c4ccnn4c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H18 compound treatment 0.368 0.0187 0.96 0.358 0.00239 0.14 0.7798 0.8044 1909043 Bionet1_001836 COc1ccc(cc1)S(=O)(=O)N(CC(=O)NC(C)(C)C#C)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H19 compound treatment 0.371 0.0217 1.11 0.372 0.0164 0.99 1.4859 0.9983 1321454 Bionet1_001837 CCOC(=O)c1nocc1C(=O)c2ccc3noc(c4ccc(Cl)cc4)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H20 compound treatment 0.361 0.0118 0.6 0.358 0.00239 0.14 0.5267 0.8525 1553649 Bionet1_001838 COc1ccc(cc1)S(=O)(=O)N(CC(=O)Nc2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H21 compound treatment 0.358 0.00875 0.45 0.365 0.00939 0.57 0.7171 0.9932 1909044 Bionet1_001839 C/C(=C(/C#N)\C(=O)N)/Nc1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H22 compound treatment 0.362 0.0127 0.65 0.363 0.00739 0.45 0.7763 0.9828 1187229 Bionet1_001840 COc1ccc(cc1)S(=O)(=O)N(CC(=O)N2CCCC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H23 positive control 0.09 -0.259 -13.26 0.092 -0.264 -15.91 -20.6263 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 H24 positive control 0.097 -0.252 -12.9 0.1 -0.256 -15.43 -20.0317 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I01 mock treatment 0.342 -0.00725 -0.37 0.353 -0.00261 -0.16 -0.3737 -0.9275 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I02 mock treatment 0.352 0.00275 0.14 0.353 -0.00261 -0.16 -0.0121 -0.0573 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I03 compound treatment 0.37 0.0208 1.06 0.367 0.0114 0.69 1.2363 0.9779 1909045 Bionet1_001841 COc1cccc(Cn2c(nc3ccccc23)c4cccnc4Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I04 compound treatment 0.333 -0.0163 -0.83 0.334 -0.0216 -1.3 -1.5101 -0.9763 1384369 Bionet1_001842 OC(CSc1ccc(Cl)c(Cl)c1)CN2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I05 compound treatment 0.357 0.00775 0.4 0.362 0.00639 0.39 0.5529 0.9999 1477856 Bionet1_001843 Clc1cccc(Cl)c1Cn2c(nc3ccccc23)c4cccnc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I06 compound treatment 0.332 -0.0173 -0.88 0.342 -0.0136 -0.82 -1.2048 -0.9994 1909046 Bionet1_001844 CCOC(=O)C1=C(C)N(Cc2ccc(Cl)cc2Cl)c3ccccc3S1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I07 compound treatment 0.356 0.00675 0.35 0.357 0.00139 0.08 0.3033 0.8539 1165855 Bionet1_001845 Fc1cccc(Cl)c1Cn2c(nc3ccccc23)c4cccnc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I08 compound treatment 0.356 0.00675 0.35 0.343 -0.0126 -0.76 -0.2944 -0.3521 1909047 Bionet1_001846 CCOC(=O)C1=C(C)N(Cc2c(Cl)cccc2Cl)c3ccccc3S1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I09 compound treatment 0.353 0.00375 0.19 0.355 -6.13E-4 -0.04 0.1094 0.5603 1909048 Bionet1_001847 Clc1cccc(Cn2c(nc3ccccc23)c4cccnc4Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I10 compound treatment 0.351 0.00175 0.09 0.363 0.00739 0.45 0.3786 0.8324 1909049 Bionet1_001848 CCOC(=O)C1=C(C)N(Cc2c(F)cccc2Cl)c3ccccc3S1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I11 compound treatment 0.366 0.0168 0.86 0.361 0.00539 0.33 0.8356 0.9121 1909050 Bionet1_001849 Clc1ccc(Cn2c(nc3ccccc23)c4cccnc4Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I12 compound treatment 0.345 -0.00425 -0.22 0.356 3.87E-4 0.02 -0.1371 -0.6275 1909051 Bionet1_001850 CCOC(=O)C1=C(C)N(Cc2ccccc2Cl)c3ccccc3S1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I13 compound treatment 0.358 0.00875 0.45 0.374 0.0184 1.11 1.1013 0.9202 1909052 Bionet1_001851 FC(F)(F)c1cccc(Cn2c(nc3ccccc23)c4cccnc4Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I14 compound treatment 0.352 0.00275 0.14 0.356 3.87E-4 0.02 0.116 0.8135 1909053 Bionet1_001852 CCOC(=O)C1=C(C)N(Cc2cc(Cl)ccc2Cl)c3ccccc3S1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I15 compound treatment 0.372 0.0227 1.16 0.354 -0.00161 -0.1 0.7537 0.6457 1909054 Bionet1_001853 FC(F)(F)c1ccc(Cn2c(nc3ccccc23)c4cccnc4Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I16 compound treatment 0.385 0.0357 1.83 0.368 0.0124 0.75 1.8213 0.9222 1909055 Bionet1_001854 FC(F)(F)c1cnc(/C(=N/Nc2ccccc2)/c3cccnc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I17 compound treatment 0.352 0.00275 0.14 0.365 0.00939 0.57 0.5001 0.8566 1182447 Bionet1_001855 CC(C)C(NC(=O)c1ccccc1Cl)c2nc3cc(C)c(C)cc3[nH]2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I18 compound treatment 0.293 -0.0563 -2.88 0.304 -0.0516 -3.12 -4.237 -0.9992 1909056 Bionet1_001856 CN1CCN(CC1)c2cc(cnc2C(=O)c3ccc(cc3)[N+](=O)[O-])C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I19 compound treatment 0.383 0.0338 1.73 0.392 0.0364 2.2 2.7735 0.9929 1652329 Bionet1_001857 Cc1ccc(SCc2nc3ccccc3n2CC(=O)Nc4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I20 compound treatment 0.363 0.0138 0.7 0.357 0.00139 0.08 0.5564 0.7858 1909057 Bionet1_001858 [O-][N+](=O)c1ccc(cc1)C(=O)c2ncc(cc2N3CCOCC3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I21 compound treatment 0.353 0.00375 0.19 0.36 0.00439 0.26 0.3229 0.9874 1909058 Bionet1_001859 COc1ccc(NC(=O)CS(=O)c2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I22 compound treatment 0.368 0.0187 0.96 0.358 0.00239 0.14 0.7798 0.8044 1909059 Bionet1_001860 FC(F)(F)c1cnc(C(=O)c2ccc(Cl)cc2)c(c1)N3CCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I23 positive control 0.09 -0.259 -13.26 0.095 -0.261 -15.73 -20.4982 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 I24 positive control 0.095 -0.254 -13.0 0.098 -0.258 -15.55 -20.1894 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J01 mock treatment 0.346 -0.00325 -0.17 0.353 -0.00261 -0.16 -0.229 -0.9997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J02 mock treatment 0.355 0.00575 0.29 0.365 0.00939 0.57 0.6086 0.9533 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J03 compound treatment 0.377 0.0278 1.42 0.384 0.0284 1.71 2.2151 0.9956 1909060 Bionet1_001861 CN(C)/C=C/c1nc(C)c(C#N)c(c1C#N)c2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J04 compound treatment 0.359 0.00975 0.5 0.36 0.00439 0.26 0.5398 0.9562 1376871 Bionet1_001862 CN(C)C(=O)CN(c1ccccc1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J05 compound treatment 0.359 0.00975 0.5 0.371 0.0154 0.93 1.0093 0.9574 1909061 Bionet1_001863 CN(C)/C=C/c1c(C#N)c(=O)ncn1N(C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J06 compound treatment 0.366 0.0168 0.86 0.365 0.00939 0.57 1.0063 0.9799 1909062 Bionet1_001864 Clc1ccc(cc1)S(=O)(=O)N(CC(=O)NCC=C)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J07 compound treatment 0.425 0.0757 3.87 0.429 0.0734 4.43 5.8715 0.9978 1909063 Bionet1_001865 COc1ccc(CCn2cnc(=O)c(C#N)c2/C=C/N(C)C)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J08 compound treatment 0.361 0.0118 0.6 0.368 0.0124 0.75 0.9536 0.9941 1389648 Bionet1_001866 Fc1ccc(NC(=O)CN(c2ccccc2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J09 compound treatment 0.47 0.121 6.17 0.444 0.0884 5.34 8.1388 0.9974 1909064 Bionet1_001867 C/C(=N/Nc1ccccc1F)/c2ccc3noc(c4ccc(F)cc4)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J10 compound treatment 0.362 0.0127 0.65 0.364 0.00839 0.51 0.819 0.9922 1529841 Bionet1_001868 O=C(CN(c1ccccc1)S(=O)(=O)c2ccccc2)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J11 compound treatment 0.385 0.0357 1.83 0.401 0.0454 2.74 3.23 0.9806 1909065 Bionet1_001869 Fc1ccc(cc1)c2onc3ccc(cc23)c4ccn(n4)c5cccc(F)c5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J12 compound treatment 0.359 0.00975 0.5 0.347 -0.00861 -0.52 -0.0151 -0.021 1554895 Bionet1_001870 CN(C)C(=O)CN(c1ccccc1)S(=O)(=O)c2cc(Cl)ccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J13 compound treatment 0.402 0.0527 2.7 0.397 0.0414 2.5 3.6739 0.9993 1909066 Bionet1_001871 Fc1ccc(cc1)c2onc3ccc(cc23)c4ccn(n4)c5ccccc5F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J14 compound treatment 0.356 0.00675 0.35 0.355 -6.13E-4 -0.04 0.2179 0.6277 1416296 Bionet1_001872 Fc1ccc(cc1)S(=O)(=O)N(CC(=O)N2CCCC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J15 compound treatment 0.358 0.00875 0.45 0.352 -0.00361 -0.22 0.1621 0.3258 1909067 Bionet1_001873 FC(F)(F)c1cnc(NCCNc2cc[nH]c(=O)c2C#N)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J16 compound treatment 0.368 0.0187 0.96 0.36 0.00439 0.26 0.8652 0.8699 1200806 Bionet1_001874 Fc1ccc(cc1)S(=O)(=O)N(CC(=O)N2CCOCC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J17 compound treatment 0.357 0.00775 0.4 0.364 0.00839 0.51 0.6382 0.9927 1909068 Bionet1_001875 CCOC(=O)C(Cc1ccc(COC)cc1)(NC(=O)C)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J18 compound treatment 0.356 0.00675 0.35 0.357 0.00139 0.08 0.3033 0.8539 1352110 Bionet1_001876 O=C(CN(c1ccccc1)S(=O)(=O)c2ccccc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J19 compound treatment 0.356 0.00675 0.35 0.355 -6.13E-4 -0.04 0.2179 0.6277 1255082 Bionet1_001877 Fc1ccc(cc1)c2onc3ccc(cc23)c4ccnc(n4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J20 compound treatment 0.372 0.0227 1.16 0.37 0.0144 0.87 1.4367 0.9896 1513922 Bionet1_001878 COc1ccc(NC(=O)CN(c2ccccc2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J21 compound treatment 0.358 0.00875 0.45 0.362 0.00639 0.39 0.589 0.9973 1909069 Bionet1_001879 COC(=O)C1(NOC2C1C(=O)N(C2=O)c3ccc(Cl)cc3)C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J22 compound treatment 0.36 0.0107 0.55 0.36 0.00439 0.26 0.5759 0.9439 1446800 Bionet1_001880 O=C(CN(c1ccccc1)S(=O)(=O)c2ccccc2)NCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J23 positive control 0.087 -0.262 -13.41 0.091 -0.265 -15.97 -20.7774 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 J24 positive control 0.095 -0.254 -13.0 0.098 -0.258 -15.55 -20.1894 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K01 mock treatment 0.345 -0.00425 -0.22 0.357 0.00139 0.08 -0.0945 -0.4056 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K02 mock treatment 0.35 7.5E-4 0.04 0.362 0.00639 0.39 0.2998 0.7736 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K03 compound treatment 0.348 -0.00125 -0.06 0.361 0.00539 0.33 0.1848 0.5575 1721912 Bionet1_001881 Fc1ccccc1NC(=O)Cn2c(CSc3ccccc3)nc4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K04 compound treatment 0.36 0.0107 0.55 0.358 0.00239 0.14 0.4906 0.8633 1909070 Bionet1_001882 FC(F)(F)c1cnc(C(=O)c2ccc(Cl)cc2)c(c1)N3CCCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K05 compound treatment 0.333 -0.0163 -0.83 0.35 -0.00561 -0.34 -0.8271 -0.9218 1330692 Bionet1_001883 O=C(Cn1c(CSc2ccccc2)nc3ccccc13)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K06 compound treatment 0.355 0.00575 0.29 0.368 0.0124 0.75 0.7367 0.9168 1909071 Bionet1_001884 FC(F)(F)c1cnc(C(=O)c2ccc(Cl)cc2)c(c1)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K07 compound treatment 0.368 0.0187 0.96 0.368 0.0124 0.75 1.2067 0.9924 1909072 Bionet1_001885 Cc1cccn2c(=O)nc(SCc3cccc(c3)C(F)(F)F)nc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K08 compound treatment 0.337 -0.0123 -0.63 0.347 -0.00861 -0.52 -0.8106 -0.9957 1909073 Bionet1_001886 FC(F)(F)c1cnc(C(=O)c2ccccc2)c(c1)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K09 compound treatment 0.354 0.00475 0.24 0.363 0.00739 0.45 0.4871 0.9592 1909074 Bionet1_001887 Cc1ccc2nc(SCc3cccc(c3)C(F)(F)F)nc(=O)n2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K10 compound treatment 0.338 -0.0113 -0.58 0.345 -0.0106 -0.64 -0.8598 -0.9986 1909075 Bionet1_001888 O/N=C(\c1ccc(Cl)cc1Cl)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K11 compound treatment 0.351 0.00175 0.09 0.349 -0.00661 -0.4 -0.219 -0.5353 1909076 Bionet1_001889 COc1nc(N)c(cc1C#N)S(=O)(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K12 compound treatment 0.345 -0.00425 -0.22 0.349 -0.00661 -0.4 -0.4359 -0.9591 1909077 Bionet1_001890 FC(F)(F)c1cnc2c(nnc(c3ccccc3)c2c1)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K13 compound treatment 0.346 -0.00325 -0.17 0.344 -0.0116 -0.7 -0.6132 -0.8511 1909078 Bionet1_001891 Nc1nc(cc(c1C#N)c2c(Cl)cccc2Cl)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K14 compound treatment 0.36 0.0107 0.55 0.353 -0.00261 -0.16 0.2771 0.4846 1909079 Bionet1_001892 COc1ccc(cc1)N2CCN(CC2)/C(=C/C#N)/NC(=O)Nc3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K15 compound treatment 0.349 -2.5E-4 -0.01 0.361 0.00539 0.33 0.2209 0.6788 1909080 Bionet1_001893 Nc1nc(cc(c1C#N)c2ccc(Cl)cc2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K16 compound treatment 0.356 0.00675 0.35 0.368 0.0124 0.75 0.7728 0.9383 1909081 Bionet1_001894 CN(N/C(=C/C#N)/NC(=O)NC(C)(C)C)c1ncc(cc1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K17 compound treatment 0.38 0.0308 1.57 0.372 0.0164 0.99 1.8113 0.9751 1909082 Bionet1_001895 Nc1nc(cc(c1C#N)c2ccc(Cl)cc2)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K18 compound treatment 0.358 0.00875 0.45 0.357 0.00139 0.08 0.3756 0.8251 1909083 Bionet1_001896 CN(NC(=O)NC(=O)c1c[nH]nc1C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K19 compound treatment 0.391 0.0418 2.13 0.389 0.0334 2.02 2.9347 0.9996 1490824 Bionet1_001897 COc1ccc(cc1)c2cc(nc(N)c2C#N)c3ccc(OC)c(OC)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K20 compound treatment 0.457 0.108 5.51 0.454 0.0984 5.94 8.0957 0.9993 1909084 Bionet1_001898 [O-][N+](=O)c1ccc(cc1)N2CCC3(CC2)NCCc4c3[nH]c5ccccc45 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K21 compound treatment 0.35 7.5E-4 0.04 0.35 -0.00561 -0.34 -0.2125 -0.6231 1729259 Bionet1_001899 COc1ccc(cc1)c2c(C)c(nc(N)c2C#N)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K22 compound treatment 0.363 0.0138 0.7 0.358 0.00239 0.14 0.599 0.8347 1909085 Bionet1_001900 CCOC(=O)/C(=C(/N)\N1CCN(CC1)c2ccc(OC)cc2)/SC#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K23 positive control 0.091 -0.258 -13.2 0.093 -0.263 -15.85 -20.5474 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 K24 positive control 0.097 -0.252 -12.9 0.105 -0.251 -15.13 -19.8182 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L01 mock treatment 0.348 -0.00125 -0.06 0.356 3.87E-4 0.02 -0.0287 -0.4213 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L02 mock treatment 0.353 0.00375 0.19 0.355 -6.13E-4 -0.04 0.1094 0.5603 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L03 compound treatment 0.349 -2.5E-4 -0.01 0.359 0.00339 0.2 0.1355 0.6616 1909086 Bionet1_001901 CCOC(=O)C1=NOC2C1C(=O)N(C2=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L04 compound treatment 0.358 0.00875 0.45 0.365 0.00939 0.57 0.7171 0.9932 1909087 Bionet1_001902 FC(F)(F)c1nnc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L05 compound treatment 0.353 0.00375 0.19 0.36 0.00439 0.26 0.3229 0.9874 1909088 Bionet1_001903 CCOC(=O)C1=NOC2C1C(=O)N(C2=O)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L06 compound treatment 0.411 0.0617 3.16 0.42 0.0644 3.89 4.9811 0.9947 1715321 Bionet1_001904 Clc1ccc(Oc2nc3ccccc3cc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L07 compound treatment 0.401 0.0517 2.65 0.408 0.0524 3.16 4.1073 0.9961 1909089 Bionet1_001905 COc1ccc(CO/N=C(/C)\c2ccc3noc(c4ccccc4)c3c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L08 compound treatment 0.373 0.0238 1.21 0.388 0.0324 1.96 2.2412 0.9738 1189417 Bionet1_001906 COc1ccc(Oc2nc3ccccc3cc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L09 compound treatment 0.41 0.0607 3.11 0.412 0.0564 3.4 4.6035 0.999 1909090 Bionet1_001907 COc1ccc(N/C=C/C(=O)c2ccc3noc(c4ccccc4)c3c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L10 compound treatment 0.402 0.0527 2.7 0.404 0.0484 2.92 3.9727 0.9992 1132092 Bionet1_001908 Cc1cc(C)cc(Oc2nc3ccccc3cc2c4ccc(Cl)cc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L11 compound treatment 0.374 0.0248 1.27 0.37 0.0144 0.87 1.509 0.9831 1909091 Bionet1_001909 Clc1ccc(CSc2ccsc2C(=O)Nc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L12 compound treatment 0.371 0.0217 1.11 0.373 0.0174 1.05 1.5286 0.9996 1909092 Bionet1_001910 Cc1ccc(CNS(=O)(=O)NCc2ccc(Cl)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L13 compound treatment 0.377 0.0278 1.42 0.377 0.0214 1.29 1.9163 0.9989 1909093 Bionet1_001911 Cc1ccc(NC(=O)c2sccc2SCc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L14 compound treatment 0.373 0.0238 1.21 0.361 0.00539 0.33 1.0887 0.866 1909094 Bionet1_001912 Cc1ccc(CNS(=O)(=O)NCc2cccc(c2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L15 compound treatment 0.348 -0.00125 -0.06 0.348 -0.00761 -0.46 -0.3702 -0.7978 1430573 Bionet1_001913 COC(=O)CS(=O)(=O)c1ccsc1C(=O)Nc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L16 compound treatment 0.352 0.00275 0.14 0.359 0.00339 0.2 0.244 0.9833 1584425 Bionet1_001914 COc1ccc(CNS(=O)(=O)NCc2ccc(OC)c(OC)c2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L17 compound treatment 0.368 0.0187 0.96 0.373 0.0174 1.05 1.4201 0.999 1909095 Bionet1_001915 Clc1cccc(Cl)c1CSc2ccsc2C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L18 compound treatment 0.359 0.00975 0.5 0.358 0.00239 0.14 0.4544 0.8757 1909096 Bionet1_001916 Fc1ccccc1CNS(=O)(=O)NCc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L19 compound treatment 0.355 0.00575 0.29 0.353 -0.00261 -0.16 0.0964 0.2888 1909097 Bionet1_001917 CNC(=O)c1sccc1S(=O)(=O)Cc2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L20 compound treatment 0.352 0.00275 0.14 0.361 0.00539 0.33 0.3294 0.9297 1222053 Bionet1_001918 COc1ccc(CNS(=O)(=O)NCc2ccc(C)cc2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L21 compound treatment 0.355 0.00575 0.29 0.352 -0.00361 -0.22 0.0537 0.1466 1616476 Bionet1_001919 COC(=O)CS(=O)(=O)c1ccsc1C(=O)Nc2ccc(F)c(F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L22 compound treatment 0.36 0.0107 0.55 0.364 0.00839 0.51 0.7467 0.9992 1582662 Bionet1_001920 COc1ccc(CNS(=O)(=O)NCc2ccc(OC)c(OC)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L23 positive control 0.092 -0.257 -13.15 0.094 -0.262 -15.79 -20.4686 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 L24 positive control 0.096 -0.253 -12.95 0.105 -0.251 -15.13 -19.8544 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M01 mock treatment 0.349 -2.5E-4 -0.01 0.363 0.00739 0.45 0.3063 0.6866 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M02 mock treatment 0.352 0.00275 0.14 0.359 0.00339 0.2 0.244 0.9833 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M03 compound treatment 0.371 0.0217 1.11 0.384 0.0284 1.71 1.9982 0.9781 1909098 Bionet1_001921 Cc1c(nc(N)c(C#N)c1c2ccccc2Cl)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M04 compound treatment 0.358 0.00875 0.45 0.357 0.00139 0.08 0.3756 0.8251 1909099 Bionet1_001922 CN1O[C@H]2[C@@H]([C@H]1c3ccccc3)C(=O)N(C2=O)c4cccc(c4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M05 compound treatment 0.343 -0.00625 -0.32 0.361 0.00539 0.33 0.004 0.0087 1909100 Bionet1_001923 FC(F)(F)c1cnc(c2cnn(c2)c3ccccc3Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M06 compound treatment 0.35 7.5E-4 0.04 0.362 0.00639 0.39 0.2998 0.7736 1909101 Bionet1_001924 CN1O[C@H]2[C@@H]([C@H]1c3ccccc3)C(=O)N(C2=O)c4ccc(Cl)cc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M07 compound treatment 0.403 0.0537 2.75 0.399 0.0434 2.62 3.7954 0.9997 1909102 Bionet1_001925 CO/N=C/c1c(N)c(sc1Nc2ccccc2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M08 compound treatment 0.358 0.00875 0.45 0.362 0.00639 0.39 0.589 0.9973 1909103 Bionet1_001926 O=C1[C@H]2ON(Cc3ccccc3)[C@@H]([C@H]2C(=O)N1Cc4ccccc4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M09 compound treatment 0.418 0.0688 3.52 0.441 0.0854 5.15 6.1306 0.9826 1909104 Bionet1_001927 Clc1cccc(Cl)c1CSc2nccc(/C=C/c3ccccc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M10 compound treatment 0.335 -0.0143 -0.73 0.362 0.00639 0.39 -0.2426 -0.2943 1909105 Bionet1_001928 CN(NC(=O)NC(=O)c1cn(C)nc1C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M11 compound treatment 0.377 0.0278 1.42 0.375 0.0194 1.17 1.8309 0.9954 1909106 Bionet1_001929 FC(F)(F)c1cnc(Sc2nccc(/C=C/c3ccccc3)n2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M12 compound treatment 0.388 0.0388 1.98 0.404 0.0484 2.92 3.4665 0.9821 1581123 Bionet1_001930 CCOC(=O)c1c(n2cccc2)c3ccccc3n1Cc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M13 compound treatment 0.417 0.0678 3.46 0.403 0.0474 2.86 4.4724 0.9955 1909107 Bionet1_001931 CCOC(=O)c1sc(=S)sc1SCC(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M14 compound treatment 0.405 0.0558 2.85 0.42 0.0644 3.89 4.7642 0.9884 1909108 Bionet1_001932 CCOC(=O)NC(=O)/C(=C\Nc1c([nH]c2ccccc12)C(=O)OCC)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M15 compound treatment 0.345 -0.00425 -0.22 0.35 -0.00561 -0.34 -0.3933 -0.9769 1909109 Bionet1_001933 Clc1ccc(N/C=C/2\C(=O)CC3N(CCc4ccccc34)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M16 compound treatment 0.349 -2.5E-4 -0.01 0.354 -0.00161 -0.1 -0.0779 -0.7931 1909110 Bionet1_001934 Cc1nn(C(=O)c2ccccc2)c(C)c1CS(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M17 compound treatment 0.36 0.0107 0.55 0.359 0.00339 0.2 0.5333 0.9093 1909111 Bionet1_001935 FC(F)(F)c1cnc(CS/C=C\C(=O)c2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M18 compound treatment 0.359 0.00975 0.5 0.358 0.00239 0.14 0.4544 0.8757 1909112 Bionet1_001936 Cc1nn(c(C)c1CS(=O)(=O)c2ccccc2)S(=O)(=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M19 compound treatment 0.353 0.00375 0.19 0.362 0.00639 0.39 0.4082 0.948 1909113 Bionet1_001937 FC(F)(F)c1cnc(S/C=C\C(=O)c2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M20 compound treatment 0.357 0.00775 0.4 0.36 0.00439 0.26 0.4675 0.9808 1909114 Bionet1_001938 Cc1nn(C(=O)c2cccnc2)c(C)c1CS(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M21 compound treatment 0.363 0.0138 0.7 0.363 0.00739 0.45 0.8125 0.9759 1909115 Bionet1_001939 FC(F)(F)c1cnc(c(Cl)c1)c2cnc3cc(nn3c2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M22 compound treatment 0.367 0.0177 0.91 0.367 0.0114 0.69 1.1278 0.9906 1909116 Bionet1_001940 Clc1ccc(cn1)c2nc3cc(Cl)c(Cl)cc3n2Cc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M23 positive control 0.094 -0.255 -13.05 0.094 -0.262 -15.79 -20.3963 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 M24 positive control 0.096 -0.253 -12.95 0.16 -0.196 -11.81 -17.5066 -0.9989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N01 mock treatment 0.348 -0.00125 -0.06 0.347 -0.00861 -0.52 -0.4129 -0.7881 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N02 mock treatment 0.352 0.00275 0.14 0.36 0.00439 0.26 0.2867 0.9561 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N03 compound treatment 0.379 0.0297 1.52 0.396 0.0404 2.44 2.7996 0.9742 1235719 Bionet1_001941 Clc1ccccc1CSc2nc(c([nH]2)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N04 compound treatment 0.351 0.00175 0.09 0.351 -0.00461 -0.28 -0.1336 -0.4569 1129547 Bionet1_001942 COc1ccc(CNS(=O)(=O)NCc2ccc(Cl)cc2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N05 compound treatment 0.393 0.0437 2.24 0.401 0.0454 2.74 3.5193 0.9949 1283265 Bionet1_001943 Fc1ccc(CSc2nc(c([nH]2)c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N06 compound treatment 0.35 7.5E-4 0.04 0.357 0.00139 0.08 0.0863 0.9373 1909117 Bionet1_001944 CC(C)(C)c1ccc(cc1)S(=O)(=O)Oc2ccc(cc2)c3csnn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N07 compound treatment 0.374 0.0248 1.27 0.383 0.0274 1.65 2.0639 0.9913 1522118 Bionet1_001945 COc1ccc(CSc2nc(c([nH]2)c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N08 compound treatment 0.362 0.0127 0.65 0.357 0.00139 0.08 0.5202 0.7914 1909118 Bionet1_001946 COC(=O)N/N=C(/C)\c1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N09 compound treatment 0.36 0.0107 0.55 0.363 0.00739 0.45 0.704 0.9946 1909119 Bionet1_001947 Cn1c(SCc2ccccc2Cl)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N10 compound treatment 0.361 0.0118 0.6 0.363 0.00739 0.45 0.7402 0.9892 1909120 Bionet1_001948 FC(F)(F)c1cnc(Oc2ccc(cc2)c3csnn3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N11 compound treatment 0.359 0.00975 0.5 0.355 -6.13E-4 -0.04 0.3264 0.6528 1649621 Bionet1_001949 Cn1c(SCc2ccc(F)cc2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N12 compound treatment 0.359 0.00975 0.5 0.365 0.00939 0.57 0.7532 0.998 1909121 Bionet1_001950 Clc1ccc(cc1)S(=O)(=O)Oc2ccc(cc2)c3csnn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N13 compound treatment 0.392 0.0428 2.19 0.381 0.0254 1.53 2.6294 0.9849 1679641 Bionet1_001951 Fc1ccc(CSc2nc(c(c3ccccc3)n2CC#C)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N14 compound treatment 0.389 0.0398 2.03 0.387 0.0314 1.89 2.777 0.9994 1909122 Bionet1_001952 Clc1ccc(/C=C/C(=O)c2ccc(Br)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N15 compound treatment 0.355 0.00575 0.29 0.352 -0.00361 -0.22 0.0537 0.1466 1551171 Bionet1_001953 COc1ccc(CSc2nc(c(c3ccccc3)n2C)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N16 compound treatment 0.358 0.00875 0.45 0.355 -6.13E-4 -0.04 0.2902 0.6464 1909123 Bionet1_001954 Clc1ccc(cc1)S(=O)(=O)Oc2ccccc2c3csnn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N17 compound treatment 0.36 0.0107 0.55 0.361 0.00539 0.33 0.6186 0.9686 1909124 Bionet1_001955 Cn1nc(c(CSc2c(Cl)cccc2Cl)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N18 compound treatment 0.358 0.00875 0.45 0.352 -0.00361 -0.22 0.1621 0.3258 1909125 Bionet1_001956 Nc1cccc(Cl)c1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N19 compound treatment 0.365 0.0158 0.81 0.362 0.00639 0.39 0.8421 0.9431 1909126 Bionet1_001957 Cn1nc(c(CSc2ccc(Br)cc2)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N20 compound treatment 0.365 0.0158 0.81 0.365 0.00939 0.57 0.9702 0.9852 1909127 Bionet1_001958 [O-][N+](=O)c1cc(Cl)ccc1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N21 compound treatment 0.356 0.00675 0.35 0.362 0.00639 0.39 0.5167 0.9985 1909128 Bionet1_001959 Cn1nc(c(CSc2cccc(Cl)c2Cl)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N22 compound treatment 0.369 0.0198 1.01 0.366 0.0104 0.63 1.1575 0.9737 1909129 Bionet1_001960 Nc1cc(Cl)ccc1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N23 positive control 0.094 -0.255 -13.05 0.097 -0.259 -15.61 -20.2682 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 N24 positive control 0.096 -0.253 -12.95 0.098 -0.258 -15.55 -20.1532 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O01 mock treatment 0.354 0.00475 0.24 0.362 0.00639 0.39 0.4444 0.9752 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O02 mock treatment 0.351 0.00175 0.09 0.363 0.00739 0.45 0.3786 0.8324 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O03 compound treatment 0.35 7.5E-4 0.04 0.36 0.00439 0.26 0.2144 0.8011 1909130 Bionet1_001961 FC(F)(F)c1cc(Cl)c(=S)n(/C=C/C(=O)c2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O04 compound treatment 0.363 0.0138 0.7 0.365 0.00939 0.57 0.8979 0.9943 1414452 Bionet1_001962 Clc1cc2nc(c3ccc(=O)[nH]c3)n(Cc4ccccc4)c2cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O05 compound treatment 0.356 0.00675 0.35 0.36 0.00439 0.26 0.4313 0.9914 1909131 Bionet1_001963 Cc1nn2cc(cnc2c1Br)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O06 compound treatment 0.378 0.0288 1.47 0.374 0.0184 1.11 1.8244 0.9904 1219734 Bionet1_001964 Cc1ccccc1Cn2c(nc3cc(Cl)c(Cl)cc23)c4ccc(=O)[nH]c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O07 compound treatment 0.384 0.0348 1.78 0.375 0.0194 1.17 2.084 0.9795 1909132 Bionet1_001965 FC(F)(F)c1cnc(c(Cl)c1)c2cnc3c(cnn3c2)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O08 compound treatment 0.352 0.00275 0.14 0.365 0.00939 0.57 0.5001 0.8566 1195809 Bionet1_001966 Fc1ccccc1Cn2c(nc3cc(Cl)c(Cl)cc23)c4ccc[nH]c4=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O09 compound treatment 0.359 0.00975 0.5 0.364 0.00839 0.51 0.7105 1.0 1909133 Bionet1_001967 FC(F)(F)c1cccc(NC(=O)N2CCc3ccccc3C2CC#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O10 compound treatment 0.386 0.0367 1.88 0.388 0.0324 1.96 2.7112 0.9998 1641154 Bionet1_001968 Fc1cccc(Cn2c(nc3cc(Cl)c(Cl)cc23)c4ccc[nH]c4=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O11 compound treatment 0.352 0.00275 0.14 0.356 3.87E-4 0.02 0.116 0.8135 1318947 Bionet1_001969 Clc1ccc(NC(=O)N2CCc3ccccc3C2CC#N)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O12 compound treatment 0.381 0.0318 1.62 0.381 0.0254 1.53 2.2316 0.9996 1493154 Bionet1_001970 Fc1ccc(Cn2c(nc3cc(Cl)c(Cl)cc23)c4ccc[nH]c4=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O13 compound treatment 0.345 -0.00425 -0.22 0.348 -0.00761 -0.46 -0.4786 -0.9415 1909134 Bionet1_001971 FC(F)(F)c1ccc(NC(=O)N2CCc3ccccc3C2CC#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O14 compound treatment 0.37 0.0208 1.06 0.367 0.0114 0.69 1.2363 0.9779 1389046 Bionet1_001972 Cc1ccccc1Cn2c(nc3cc(Cl)c(Cl)cc23)c4ccc[nH]c4=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O15 compound treatment 0.378 0.0288 1.47 0.383 0.0274 1.65 2.2086 0.9983 1909135 Bionet1_001973 COC(=O)c1sc2ncc(cc2c1N)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O16 compound treatment 0.355 0.00575 0.29 0.347 -0.00861 -0.52 -0.1598 -0.2675 1207705 Bionet1_001974 CC(O)(CS(=O)(=O)c1ccc(Br)cc1)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O17 compound treatment 0.369 0.0198 1.01 0.372 0.0164 0.99 1.4136 0.9999 1909136 Bionet1_001975 CC(C(=O)Nc1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O18 compound treatment 0.361 0.0118 0.6 0.366 0.0104 0.63 0.8682 0.9998 1437669 Bionet1_001976 Cc1ccc(Cn2c(nc3cc(Cl)c(Cl)cc23)c4ccc[nH]c4=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O19 compound treatment 0.364 0.0147 0.75 0.365 0.00939 0.57 0.934 0.9901 1909137 Bionet1_001977 COC(=O)C/1=C(C)NC(=O)\C1=C/Nc2ccc(Oc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O20 compound treatment 0.353 0.00375 0.19 0.362 0.00639 0.39 0.4082 0.948 1277226 Bionet1_001978 CC(O)(CS(=O)(=O)Cc1ccc(Cl)cc1)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O21 compound treatment 0.393 0.0437 2.24 0.393 0.0374 2.26 3.1778 1.0 1909138 Bionet1_001979 CN(C)/C=C/c1snc(Sc2ncc(cc2Cl)C(F)(F)F)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O22 compound treatment 0.362 0.0127 0.65 0.363 0.00739 0.45 0.7763 0.9828 1604510 Bionet1_001980 COc1ccc(CS(=O)(=O)CC(C)(O)c2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O23 positive control 0.088 -0.261 -13.36 0.093 -0.263 -15.85 -20.6559 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 O24 positive control 0.094 -0.255 -13.05 0.097 -0.259 -15.61 -20.2682 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P01 mock treatment 0.36 0.0107 0.55 0.374 0.0184 1.11 1.1736 0.9475 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P02 mock treatment 0.356 0.00675 0.35 0.364 0.00839 0.51 0.6021 0.9826 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P03 compound treatment 0.361 0.0118 0.6 0.361 0.00539 0.33 0.6548 0.9585 1502958 Bionet1_001981 Fc1ccc(NC(=O)Cc2sc(nc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P04 compound treatment 0.363 0.0138 0.7 0.37 0.0144 0.87 1.1113 0.9945 1909139 Bionet1_001982 FC(F)(F)c1cnc(NCCn2c(=O)cc(Cl)[nH]c2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P05 compound treatment 0.361 0.0118 0.6 0.363 0.00739 0.45 0.7402 0.9892 1220479 Bionet1_001983 O=C(Cc1sc(nc1c2ccccc2)c3ccccc3)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P06 compound treatment 0.398 0.0488 2.49 0.405 0.0494 2.98 3.8708 0.996 1909140 Bionet1_001984 [O-][N+](=O)c1cccnc1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P07 compound treatment 0.388 0.0388 1.98 0.382 0.0264 1.59 2.5274 0.9941 1563165 Bionet1_001985 Cc1ccc(CSc2nc(c([nH]2)c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P08 compound treatment 0.352 0.00275 0.14 0.364 0.00839 0.51 0.4574 0.8705 1909141 Bionet1_001986 Nc1cccnc1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P09 compound treatment 0.385 0.0357 1.83 0.389 0.0334 2.02 2.7178 0.9988 1909142 Bionet1_001987 [O-][N+](=O)c1ccc(CSc2nc(c([nH]2)c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P10 compound treatment 0.352 0.00275 0.14 0.356 3.87E-4 0.02 0.116 0.8135 1909143 Bionet1_001988 Nc1cccnc1N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P11 compound treatment 0.345 -0.00425 -0.22 0.358 0.00239 0.14 -0.0518 -0.1985 1635916 Bionet1_001989 Cn1c(SCc2cccc(F)c2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P12 compound treatment 0.392 0.0428 2.19 0.403 0.0474 2.86 3.5685 0.9912 1909144 Bionet1_001990 [O-][N+](=O)c1ccccc1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P13 compound treatment 0.385 0.0357 1.83 0.377 0.0214 1.29 2.2055 0.9855 1121458 Bionet1_001991 Fc1cccc(CSc2nc(c(c3ccccc3)n2CC#C)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P14 compound treatment 0.35 7.5E-4 0.04 0.363 0.00739 0.45 0.3424 0.7651 1909145 Bionet1_001992 Nc1ccccc1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P15 compound treatment 0.349 -2.5E-4 -0.01 0.344 -0.0116 -0.7 -0.5048 -0.7199 1176989 Bionet1_001993 Cc1ccc(CSc2nc(c(c3ccccc3)n2C)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P16 compound treatment 0.353 0.00375 0.19 0.36 0.00439 0.26 0.3229 0.9874 1909146 Bionet1_001994 FC(F)(F)c1cnc(NCCn2c(=O)c(=O)[nH]c3cccnc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P17 compound treatment 0.355 0.00575 0.29 0.363 0.00739 0.45 0.5232 0.9796 1625015 Bionet1_001995 CCCn1c(SCc2ccc(C)cc2)nc(c1c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P18 compound treatment 0.359 0.00975 0.5 0.355 -6.13E-4 -0.04 0.3264 0.6528 1909147 Bionet1_001996 NNc1nc2cccnc2n(CCNc3ncc(cc3Cl)C(F)(F)F)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P19 compound treatment 0.365 0.0158 0.81 0.357 0.00139 0.08 0.6287 0.7764 1507806 Bionet1_001997 Cc1ccc(CSc2nc(c(c3ccccc3)n2CC=C)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P20 compound treatment 0.365 0.0158 0.81 0.36 0.00439 0.26 0.7567 0.8926 1909148 Bionet1_001998 [O-][N+](=O)c1ccc(cc1)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P21 compound treatment 0.349 -2.5E-4 -0.01 0.357 0.00139 0.08 0.0502 0.5923 1557672 Bionet1_001999 Cc1ccc(CSc2nc(c(c3ccccc3)n2CC#C)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P22 compound treatment 0.353 0.00375 0.19 0.356 3.87E-4 0.02 0.1521 0.7875 1909149 Bionet1_002000 Nc1cc(ccc1NCCNc2ncc(cc2Cl)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P23 positive control 0.089 -0.26 -13.31 0.095 -0.261 -15.73 -20.5344 -0.9965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.573 P24 positive control 0.095 -0.254 -13.0 0.098 -0.258 -15.55 -20.1894 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A01 mock treatment 0.326 -0.0258 -1.32 0.321 -0.0285 -1.72 -2.1496 -0.9916 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A02 mock treatment 0.324 -0.0278 -1.42 0.323 -0.0265 -1.6 -2.1366 -0.9983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A03 compound treatment 0.339 -0.0128 -0.66 0.335 -0.0145 -0.87 -1.082 -0.9901 1909150 Bionet1_002001 Nc1ccc(cc1)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A04 compound treatment 0.338 -0.0138 -0.71 0.329 -0.0205 -1.24 -1.3743 -0.965 1660363 Bionet1_002002 Clc1ccccc1c2nc(c(CC(=O)NCC=C)s2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A05 compound treatment 0.334 -0.0178 -0.91 0.33 -0.0195 -1.18 -1.4762 -0.9922 1909151 Bionet1_002003 NC(=O)Nc1ccc(cc1)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A06 compound treatment 0.36 0.00816 0.42 0.364 0.0145 0.88 0.9152 0.9422 1416546 Bionet1_002004 Clc1ccc(SCC(=O)Nc2nc(cs2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A07 compound treatment 0.334 -0.0178 -0.91 0.343 -0.00647 -0.39 -0.9213 -0.9283 1214913 Bionet1_002005 CN(C)C(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A08 compound treatment 0.34 -0.0118 -0.61 0.348 -0.00147 -0.09 -0.4909 -0.8021 1241292 Bionet1_002006 Cc1ccc(SCC(=O)Nc2nc(cs2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A09 compound treatment 0.342 -0.00984 -0.5 0.341 -0.00847 -0.51 -0.7174 -1.0 1909152 Bionet1_002007 Clc1ccc(cc1)N(CC(=O)NCC=C)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A10 compound treatment 0.344 -0.00784 -0.4 0.363 0.0135 0.82 0.294 0.3231 1642983 Bionet1_002008 Clc1ccc(cc1)c2csc(NC(=O)CSc3cccc(Cl)c3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A11 compound treatment 0.331 -0.0208 -1.07 0.329 -0.0205 -1.24 -1.6274 -0.9973 1909153 Bionet1_002009 CN(C)C(=O)CN(c1cccc(c1)C(F)(F)F)S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A12 compound treatment 0.356 0.00416 0.21 0.367 0.0175 1.06 0.8986 0.8325 1326719 Bionet1_002010 Clc1ccc(cc1)c2csc(NC(=O)CSc3ccccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A13 compound treatment 0.337 -0.0148 -0.76 0.333 -0.0165 -0.99 -1.2397 -0.9911 1460525 Bionet1_002011 CN(C)C(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A14 compound treatment 0.33 -0.0218 -1.12 0.326 -0.0235 -1.42 -1.7916 -0.9931 1593558 Bionet1_002012 Cc1cccc(SCC(=O)Nc2nc(cs2)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A15 compound treatment 0.329 -0.0228 -1.17 0.322 -0.0275 -1.66 -1.9985 -0.9853 1909154 Bionet1_002013 Clc1ccc(cc1)N(CC(=O)NCC=C)S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A16 compound treatment 0.337 -0.0148 -0.76 0.337 -0.0125 -0.75 -1.0689 -1.0 1539388 Bionet1_002014 Cc1ccc(SCC(=O)Nc2nc(cs2)c3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A17 compound treatment 0.324 -0.0278 -1.42 0.324 -0.0255 -1.54 -2.0939 -0.9993 1698139 Bionet1_002015 Clc1ccc(cc1)N(CC(=O)N2CCOCC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A18 compound treatment 0.331 -0.0208 -1.07 0.323 -0.0265 -1.6 -1.8835 -0.9806 1433634 Bionet1_002016 Clc1ccc(SCC(=O)Nc2nc(cs2)c3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A19 compound treatment 0.333 -0.0188 -0.96 0.324 -0.0255 -1.54 -1.7685 -0.9747 1267968 Bionet1_002017 Cc1cccc(C)c1NC(=O)CN(c2ccccn2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A20 compound treatment 0.338 -0.0138 -0.71 0.324 -0.0255 -1.54 -1.5877 -0.938 1557783 Bionet1_002018 Fc1ccc(cc1)c2csc(NC(=O)CSc3ccc(Cl)cc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A21 compound treatment 0.332 -0.0198 -1.01 0.319 -0.0305 -1.84 -2.0181 -0.9607 1551285 Bionet1_002019 O=C(CN(c1ccccn1)S(=O)(=O)c2ccccc2)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A22 compound treatment 0.328 -0.0238 -1.22 0.32 -0.0295 -1.78 -2.12 -0.983 1510003 Bionet1_002020 Cc1ccc(SCC(=O)Nc2nc(cs2)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A23 positive control 0.087 -0.265 -13.54 0.086 -0.263 -15.91 -20.8224 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 A24 positive control 0.096 -0.256 -13.08 0.09 -0.259 -15.66 -20.3262 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B01 mock treatment 0.354 0.00216 0.11 0.346 -0.00347 -0.21 -0.0701 -0.2962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B02 mock treatment 0.364 0.0122 0.62 0.353 0.00353 0.21 0.5903 0.8983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B03 compound treatment 0.395 0.0432 2.21 0.428 0.0785 4.74 4.9126 0.9395 1909155 Bionet1_002021 [O-][N+](=O)c1cc(ccc1n2c3ccccc3c4ccccc24)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B04 compound treatment 0.354 0.00216 0.11 0.332 -0.0175 -1.05 -0.6677 -0.6297 1909156 Bionet1_002022 [O-][N+](=O)c1cccc(Cl)c1NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B05 compound treatment 0.322 -0.0298 -1.53 0.295 -0.0545 -3.29 -3.4041 -0.9391 1909157 Bionet1_002023 CC(C)(C)c1cc(/C=N\NC(=O)Nc2ccccc2)cc(c1O)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B06 compound treatment 0.383 0.0312 1.59 0.355 0.00553 0.33 1.3626 0.8371 1605306 Bionet1_002024 COc1ccc(cc1)c2nc(nc(N3CCN(C)CC3)c2C#N)c4cccc(C)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B07 compound treatment 0.368 0.0162 0.83 0.366 0.0165 1.0 1.2898 0.9956 1909158 Bionet1_002025 COC(=O)/C(=C/N(C)C)/C(=O)N1CCN(CC1)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B08 compound treatment 0.415 0.0632 3.23 0.409 0.0595 3.59 4.8247 0.9986 1909159 Bionet1_002026 Fc1ccc(/C=C\2/SC(=S)N(N3C(=O)C4C5CC(C=C5)C4C3=O)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B09 compound treatment 0.352 1.56E-4 0.01 0.352 0.00253 0.15 0.1137 0.7431 1909160 Bionet1_002027 CCOC(=O)c1noc(C)c1C(=O)Nc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B10 compound treatment 0.398 0.0462 2.36 0.39 0.0405 2.45 3.399 0.9998 1909161 Bionet1_002028 COc1cccc(/C=C/2\SC(=S)N(N3C(=O)CCCC3=O)C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B11 compound treatment 0.359 0.00716 0.37 0.355 0.00553 0.33 0.4949 0.999 1909162 Bionet1_002029 Cc1onc(C(=O)NN)c1C(=O)Nc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B12 compound treatment 0.366 0.0142 0.72 0.355 0.00553 0.33 0.7479 0.9383 1909163 Bionet1_002030 FC(F)(F)c1cccc(OCCO/N=C/c2sc3ccccc3c2Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B13 compound treatment 0.352 1.56E-4 0.01 0.361 0.0115 0.7 0.4979 0.7152 1236971 Bionet1_002031 Cc1onc(c2ccnn2c3ccc(C)cc3)c1C(=O)Nc4nccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B14 compound treatment 0.421 0.0692 3.54 0.417 0.0675 4.08 5.3831 0.9975 1909164 Bionet1_002032 COc1ccccc1/C=C/2\SC(=S)N(N3C(=O)CCCC3=O)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B15 compound treatment 0.376 0.0242 1.24 0.371 0.0215 1.3 1.7925 0.9997 1909165 Bionet1_002033 COc1ccc(N/C=C/C(=O)c2noc(C)c2C(=O)Nc3nccs3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B16 compound treatment 0.354 0.00216 0.11 0.356 0.00653 0.39 0.3568 0.8714 1909166 Bionet1_002034 COc1ccc(cc1)c2nc(nc(Cl)c2C#N)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B17 compound treatment 0.362 0.0102 0.52 0.364 0.0145 0.88 0.9875 0.9687 1909167 Bionet1_002035 FC(F)(F)c1ccc(NC(=O)CC(=O)Nc2ccc(cc2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B18 compound treatment 0.271 -0.0808 -4.13 0.264 -0.0855 -5.16 -6.5714 -0.994 1909168 Bionet1_002036 CN(C)c1nc(N(C)C)n(n1)S(=O)(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B19 compound treatment 0.351 -8.44E-4 -0.04 0.354 0.00453 0.27 0.1629 0.5883 1909169 Bionet1_002037 FC(F)(F)c1ccccc1NC(=O)CC(=O)Nc2ccccc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B20 compound treatment 0.349 -0.00284 -0.15 0.341 -0.00847 -0.51 -0.4643 -0.8736 1909170 Bionet1_002038 CN(C)c1nc(N(C)C)n(n1)S(=O)(=O)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B21 compound treatment 0.369 0.0172 0.88 0.367 0.0175 1.06 1.3687 0.9957 1909171 Bionet1_002039 CN(C)C=C(C(=O)Nc1ccccc1Cl)C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B22 compound treatment 0.358 0.00616 0.31 0.354 0.00453 0.27 0.416 0.9976 1909172 Bionet1_002040 C/C(=N/Nc1nc(cs1)c2sccc2Cl)/c3c(O)cc(C)oc3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B23 positive control 0.086 -0.266 -13.59 0.089 -0.26 -15.72 -20.7305 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 B24 positive control 0.088 -0.264 -13.49 0.089 -0.26 -15.72 -20.6581 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C01 mock treatment 0.353 0.00116 0.06 0.345 -0.00447 -0.27 -0.149 -0.5393 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C02 mock treatment 0.369 0.0172 0.88 0.356 0.00653 0.39 0.8991 0.9348 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C03 compound treatment 0.37 0.0182 0.93 0.367 0.0175 1.06 1.4048 0.9979 1909173 Bionet1_002041 CC(=O)c1cc(C#N)c(SCc2ccc(Cl)c(Cl)c2)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C04 compound treatment 0.37 0.0182 0.93 0.375 0.0255 1.54 1.7463 0.9706 1909174 Bionet1_002042 FC(F)(F)c1cnc(C#N)c(c1)S(=O)(=O)Cc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C05 compound treatment 0.39 0.0382 1.95 0.375 0.0255 1.54 2.4694 0.9932 1909175 Bionet1_002043 CC(=O)c1cc(C#N)c(SCc2cccc(c2)C(F)(F)F)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C06 compound treatment 0.357 0.00516 0.26 0.354 0.00453 0.27 0.3799 0.9998 1909176 Bionet1_002044 NC(=O)c1ncc(cc1S(=O)(=O)c2ccc(cn2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C07 compound treatment 0.384 0.0322 1.64 0.378 0.0285 1.72 2.3806 0.9997 1909177 Bionet1_002045 CC(=O)c1cc(C#N)c(SCc2ccc(Cl)cc2Cl)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C08 compound treatment 0.357 0.00516 0.26 0.354 0.00453 0.27 0.3799 0.9998 1909178 Bionet1_002046 CCC(=O)Nc1ccc(Sc2cc(cnc2C#N)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C09 compound treatment 0.353 0.00116 0.06 0.348 -0.00147 -0.09 -0.0209 -0.196 1452833 Bionet1_002047 Fc1ccc(cc1)S(=O)(=O)N(CC(=O)Nc2ccccc2)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C10 compound treatment 0.354 0.00216 0.11 0.345 -0.00447 -0.27 -0.1128 -0.387 1909179 Bionet1_002048 NC(=O)c1ncc(cc1Oc2cccc(c2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C11 compound treatment 0.352 1.56E-4 0.01 0.349 -4.69E-4 -0.03 -0.0144 -0.4884 1639653 Bionet1_002049 COC(=O)c1cc(C#N)c(Oc2cc(Cl)c(Cl)cc2Cl)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C12 compound treatment 0.355 0.00316 0.16 0.351 0.00153 0.09 0.1795 0.965 1909180 Bionet1_002050 FC(F)(F)c1cnc(c2nc[nH]n2)c(Sc3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C13 compound treatment 0.357 0.00516 0.26 0.337 -0.0125 -0.75 -0.3458 -0.4336 1909181 Bionet1_002051 CCOC(=O)c1cnn(c2nc(cs2)c3ccc(OC)cc3)c1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C14 compound treatment 0.356 0.00416 0.21 0.347 -0.00247 -0.15 0.0449 0.1729 1909182 Bionet1_002052 Fc1ccc(cc1)N2CCN(CC2)c3cc(cnc3C#N)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C15 compound treatment 0.373 0.0212 1.08 0.36 0.0105 0.64 1.2145 0.9679 1909183 Bionet1_002053 CNC(=O)c1cnn(c2nc(cs2)c3ccc(OC)cc3)c1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C16 compound treatment 0.353 0.00116 0.06 0.351 0.00153 0.09 0.1072 0.9767 1909184 Bionet1_002054 NC(=O)c1ncc(cc1Oc2ccc(cc2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C17 compound treatment 0.381 0.0292 1.49 0.373 0.0235 1.42 2.0586 0.9997 1909185 Bionet1_002055 FC(F)(F)c1ccc(cc1)C2=NNC(=O)C(C2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C18 compound treatment 0.358 0.00616 0.31 0.352 0.00253 0.15 0.3306 0.9449 1909186 Bionet1_002056 CN(C)/C=C/C(=O)c1ccc(Oc2cc(cnc2C#N)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C19 compound treatment 0.351 -8.44E-4 -0.04 0.35 5.31E-4 0.03 -0.0078 -0.1456 1909187 Bionet1_002057 COc1ccc(NC(=O)/C(=C(/Cl)\SCc2ccc(C)cc2)/Cl)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C20 compound treatment 0.352 1.56E-4 0.01 0.347 -0.00247 -0.15 -0.0997 -0.6682 1909188 Bionet1_002058 COC(=O)c1c(noc1/C(=C/N(C)C)/C(=O)C(F)(F)F)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C21 compound treatment 0.354 0.00216 0.11 0.353 0.00353 0.21 0.2287 0.9529 1909189 Bionet1_002059 COc1ccc(CS/C(=C(/Cl)\C(=O)Nc2ccc(OC)nc2)/Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C22 compound treatment 0.353 0.00116 0.06 0.346 -0.00347 -0.21 -0.1063 -0.4884 1909190 Bionet1_002060 FC(F)(F)c1cccc(c1)N2CCN(CC2)c3cc(cnc3C#N)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C23 positive control 0.086 -0.266 -13.59 0.085 -0.264 -15.97 -20.9012 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 C24 positive control 0.09 -0.262 -13.39 0.091 -0.258 -15.6 -20.5005 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D01 mock treatment 0.343 -0.00884 -0.45 0.342 -0.00747 -0.45 -0.6386 -1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D02 mock treatment 0.351 -8.44E-4 -0.04 0.35 5.31E-4 0.03 -0.0078 -0.1456 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D03 compound treatment 0.355 0.00316 0.16 0.35 5.31E-4 0.03 0.1368 0.8314 1909191 Bionet1_002061 CO/N=C/C(C(=O)Nc1ccccc1Cl)C(=O)Nc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D04 compound treatment 0.355 0.00316 0.16 0.352 0.00253 0.15 0.2222 0.9996 1909192 Bionet1_002062 CC(=O)CC(=O)c1c(C)nn(c1O)c2nc(cs2)c3sccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D05 compound treatment 0.363 0.0112 0.57 0.352 0.00253 0.15 0.5114 0.866 1909193 Bionet1_002063 CN(C)C=C(C(=O)Nc1ccc(F)cc1F)C(=O)Nc2ccc(F)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D06 compound treatment 0.366 0.0142 0.72 0.376 0.0265 1.6 1.6444 0.9356 1909194 Bionet1_002064 Fc1ccc(cc1)N2CCN(CC2)c3[nH]c(cc3C#N)c4sccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D07 compound treatment 0.346 -0.00584 -0.3 0.346 -0.00347 -0.21 -0.3594 -0.9849 1909195 Bionet1_002065 CO/N=C/C(C(=O)Nc1ccc(F)cc1F)C(=O)Nc2ccc(F)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D08 compound treatment 0.365 0.0132 0.67 0.359 0.00953 0.58 0.8825 0.997 1909196 Bionet1_002066 Fc1ccc(cc1)n2nc(C#N)c(=O)n(Cc3ccc(cc3)C(F)(F)F)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D09 compound treatment 0.347 -0.00484 -0.25 0.339 -0.0105 -0.63 -0.622 -0.9164 1909197 Bionet1_002067 CC(=O)OCc1c(Sc2ccccc2Cl)n(C)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D10 compound treatment 0.388 0.0362 1.85 0.368 0.0185 1.12 2.0983 0.971 1909198 Bionet1_002068 Cc1ccc(cc1)n2cc(cn2)c3nn(c4cc(C)cc(C)c4)c(=O)n(C)c3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D11 compound treatment 0.366 0.0142 0.72 0.356 0.00653 0.39 0.7906 0.9592 1909199 Bionet1_002069 Cc1cccc(C)c1n2c(CCl)nc3c(Cl)cc(Cl)cc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D12 compound treatment 0.367 0.0152 0.77 0.351 0.00153 0.09 0.6134 0.7859 1909200 Bionet1_002070 COC(=O)C1CCN(CC1)c2[nH]c(cc2C#N)c3sccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D13 compound treatment 0.361 0.00916 0.47 0.358 0.00853 0.52 0.6952 0.9989 1175235 Bionet1_002071 Clc1ccc(SCC(=O)Nc2nc(cs2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D14 compound treatment 0.367 0.0152 0.77 0.36 0.0105 0.64 0.9975 0.9952 1909201 Bionet1_002072 COC(=O)C1CCN(CC1)c2[nH]c(cc2C#N)c3sccc3Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D15 compound treatment 0.349 -0.00284 -0.15 0.34 -0.00947 -0.57 -0.507 -0.8596 1318903 Bionet1_002073 Clc1cccc(SCc2nc3ccccc3c(=O)n2c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D16 compound treatment 0.365 0.0132 0.67 0.358 0.00853 0.52 0.8399 0.9913 1909202 Bionet1_002074 COC(=O)C1CCN(CC1)c2[nH]c(cc2C(=O)OC)c3sccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D17 compound treatment 0.362 0.0102 0.52 0.357 0.00753 0.45 0.6887 0.9978 1526136 Bionet1_002075 Clc1cccc(SCC(=O)Nc2nc(cs2)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D18 compound treatment 0.335 -0.0168 -0.86 0.329 -0.0205 -1.24 -1.4828 -0.9844 1909203 Bionet1_002076 Cn1c(=O)c(nn(c2ccc(F)cc2F)c1=O)C(=O)CBr 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D19 compound treatment 0.371 0.0192 0.98 0.365 0.0155 0.94 1.3556 0.9998 1647762 Bionet1_002077 Clc1ccc(c2csc(NC(=O)CSc3ccccc3)n2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D20 compound treatment 0.358 0.00616 0.31 0.348 -0.00147 -0.09 0.1599 0.4889 1909204 Bionet1_002078 Cn1c(=O)c(nn(c2ccc(Cl)cc2)c1=O)c3ccnn3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D21 compound treatment 0.347 -0.00484 -0.25 0.348 -0.00147 -0.09 -0.2378 -0.9041 1220284 Bionet1_002079 Clc1ccc(cc1)c2csc(NC(=O)CSc3ccccc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D22 compound treatment 0.344 -0.00784 -0.4 0.346 -0.00347 -0.21 -0.4317 -0.9541 1440353 Bionet1_002080 Cn1c(=O)c(nn(c2ccc(F)cc2F)c1=O)c3csc(n3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D23 positive control 0.084 -0.268 -13.7 0.086 -0.263 -15.91 -20.9308 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 D24 positive control 0.091 -0.261 -13.34 0.091 -0.258 -15.6 -20.4643 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E01 mock treatment 0.346 -0.00584 -0.3 0.348 -0.00147 -0.09 -0.274 -0.879 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E02 mock treatment 0.361 0.00916 0.47 0.355 0.00553 0.33 0.5672 0.9863 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E03 compound treatment 0.301 -0.0508 -2.6 0.296 -0.0535 -3.23 -4.1207 -0.9942 1909205 Bionet1_002081 COc1ccc(NC(=O)/C(=C(/Cl)\S(=O)Cc2ccccc2)/Cl)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E04 compound treatment 0.385 0.0332 1.7 0.381 0.0315 1.9 2.5448 0.9983 1909206 Bionet1_002082 FC(F)(F)c1cnc(C#N)c(Oc2ccc(Cl)c3cccnc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E05 compound treatment 0.369 0.0172 0.88 0.354 0.00453 0.27 0.8137 0.8855 1909207 Bionet1_002083 COc1ccc(NC(=O)/C(=C(/Cl)\S(=O)Cc2ccc(C)cc2)/Cl)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E06 compound treatment 0.359 0.00716 0.37 0.371 0.0215 1.3 1.1778 0.8723 1909208 Bionet1_002084 COC(=O)c1c(noc1c2cnc(N)nc2C(F)(F)F)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E07 compound treatment 0.357 0.00516 0.26 0.357 0.00753 0.45 0.5079 0.9664 1909209 Bionet1_002085 Cc1ccc(SCCC(=O)NCCSc2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E08 compound treatment 0.362 0.0102 0.52 0.368 0.0185 1.12 1.1583 0.9391 1909210 Bionet1_002086 COC(=O)c1c(noc1c2cnc(N)nc2C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E09 compound treatment 0.358 0.00616 0.31 0.355 0.00553 0.33 0.4587 0.9996 1909211 Bionet1_002087 Clc1ccc(SCCNC(=O)CCSc2ccccc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E10 compound treatment 0.365 0.0132 0.67 0.36 0.0105 0.64 0.9252 0.9996 1909212 Bionet1_002088 COc1ccc(cc1)N2CCN(CC2)c3cc(cnc3C#N)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E11 compound treatment 0.348 -0.00384 -0.2 0.338 -0.0115 -0.69 -0.6285 -0.8733 1909213 Bionet1_002089 Clc1cccc(Cl)c1SCC(=O)NCCSc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E12 compound treatment 0.345 -0.00684 -0.35 0.337 -0.0125 -0.75 -0.7797 -0.9393 1909214 Bionet1_002090 CN(C)/C=C(\C(=O)C(F)(F)F)/c1onc(c1C#N)c2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E13 compound treatment 0.342 -0.00984 -0.5 0.342 -0.00747 -0.45 -0.6747 -0.9985 1909215 Bionet1_002091 Clc1cccc(Cl)c1SCCC(=O)NCCSc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E14 compound treatment 0.35 -0.00184 -0.09 0.342 -0.00747 -0.45 -0.3855 -0.8369 1909216 Bionet1_002092 COC(=O)C1CC(Cl)CN1S(=O)(=O)c2ccc(OC)c(OC)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E15 compound treatment 0.354 0.00216 0.11 0.349 -4.69E-4 -0.03 0.058 0.5091 1909217 Bionet1_002093 O=C(CCS(=O)(=O)c1ccccc1)NCCS(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E16 compound treatment 0.594 0.242 12.38 0.587 0.238 14.34 18.8949 0.9973 1909218 Bionet1_002094 NNC(=O)C1=NOC2COC3(CCN(CC3)c4ccc(cc4)[N+](=O)[O-])OCC21 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E17 compound treatment 0.356 0.00416 0.21 0.346 -0.00347 -0.21 0.0022 0.0074 1909219 Bionet1_002095 Fc1ccc(cc1)S(=O)(=O)CC(=O)NCCS(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E18 compound treatment 0.35 -0.00184 -0.09 0.347 -0.00247 -0.15 -0.172 -0.9756 1909220 Bionet1_002096 CN(N1C(=O)C2ON=C(C2C1=O)C(=O)C)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E19 compound treatment 0.351 -8.44E-4 -0.04 0.341 -0.00847 -0.51 -0.392 -0.7641 1909221 Bionet1_002097 COC(=O)c1ccccc1SC(C)C(=O)NCCSc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E20 compound treatment 0.359 0.00716 0.37 0.35 5.31E-4 0.03 0.2814 0.7661 1909222 Bionet1_002098 CCOC(=O)C1=NOC2COC3(CCN(CC3)c4ncccn4)OCC21 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E21 compound treatment 0.358 0.00616 0.31 0.35 5.31E-4 0.03 0.2453 0.7751 1909223 Bionet1_002099 Clc1ccc(Sc2ccccc2CSc3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E22 compound treatment 0.345 -0.00684 -0.35 0.352 0.00253 0.15 -0.1394 -0.365 1909224 Bionet1_002100 CN(NS(=O)(=O)c1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E23 positive control 0.086 -0.266 -13.59 0.085 -0.264 -15.97 -20.9012 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 E24 positive control 0.092 -0.26 -13.29 0.092 -0.257 -15.54 -20.3855 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F01 mock treatment 0.351 -8.44E-4 -0.04 0.349 -4.69E-4 -0.03 -0.0505 -0.9791 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F02 mock treatment 0.36 0.00816 0.42 0.357 0.00753 0.45 0.6164 0.9991 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F03 compound treatment 0.407 0.0552 2.82 0.397 0.0475 2.87 4.0232 1.0 1457569 Bionet1_002101 Cc1ccccc1SCC(=O)Nc2nc(cs2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F04 compound treatment 0.362 0.0102 0.52 0.361 0.0115 0.7 0.8594 0.9896 1909225 Bionet1_002102 Cn1c(=O)c(nn(c2ccc(Cl)cc2)c1=O)c3ccnc(n3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F05 compound treatment 0.379 0.0272 1.39 0.375 0.0255 1.54 2.0717 0.9986 1690949 Bionet1_002103 Cc1ccc(cc1)S(=O)(=O)CC(=O)Nc2nc(cs2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F06 compound treatment 0.362 0.0102 0.52 0.351 0.00153 0.09 0.4326 0.8201 1460474 Bionet1_002104 Cn1c(=O)c(nn(c2cc(Cl)cc(Cl)c2)c1=O)c3csc(N)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F07 compound treatment 0.367 0.0152 0.77 0.38 0.0305 1.84 1.8513 0.9259 1523184 Bionet1_002105 Clc1ccc(cc1)S(=O)(=O)CC(=O)Nc2nc(cs2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F08 compound treatment 0.41 0.0582 2.97 0.412 0.0625 3.77 4.772 0.993 1909226 Bionet1_002106 CN(C)/C=C/C(=O)c1nn(c2cccc(c2)C(F)(F)F)c(=O)n(C)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F09 compound treatment 0.354 0.00216 0.11 0.337 -0.0125 -0.75 -0.4543 -0.5972 1414598 Bionet1_002107 Cc1cccc(c1)S(=O)(=O)CC(=O)Nc2nc(cs2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F10 compound treatment 0.433 0.0812 4.15 0.43 0.0805 4.86 6.3719 0.9969 1909227 Bionet1_002108 C=CCOc1ccccc1/C=C/2\C(=O)N(N=C2c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F11 compound treatment 0.37 0.0182 0.93 0.365 0.0155 0.94 1.3194 1.0 1217857 Bionet1_002109 Clc1ccc(cc1)c2csc(NC(=O)CS(=O)(=O)c3ccccc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F12 compound treatment 0.413 0.0612 3.13 0.42 0.0705 4.26 5.2219 0.9885 1909228 Bionet1_002110 CN(C)/C=C\C(=O)c1nn(c2ccc(cc2)C(F)(F)F)c(=O)n(C)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F13 compound treatment 0.369 0.0172 0.88 0.357 0.00753 0.45 0.9418 0.9532 1327423 Bionet1_002111 COc1ccc(SCC(=O)Nc2nc(cs2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F14 compound treatment 0.383 0.0312 1.59 0.37 0.0205 1.24 2.0029 0.9923 1909229 Bionet1_002112 [O-][N+](=O)c1ccc(Cn2c(=O)c(C#N)nn(c3ccc(F)cc3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F15 compound treatment 0.355 0.00316 0.16 0.345 -0.00447 -0.27 -0.0766 -0.2438 1909230 Bionet1_002113 CC(=O)c1cccc(NS(=O)(=O)c2ccc(Br)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F16 compound treatment 0.372 0.0202 1.03 0.36 0.0105 0.64 1.1783 0.9731 1255507 Bionet1_002114 Fc1ccc(cc1)n2nc(C#N)c(=O)n(Cc3ccc(Cl)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F17 compound treatment 0.356 0.00416 0.21 0.363 0.0135 0.82 0.7279 0.8624 1909231 Bionet1_002115 FC(F)(F)c1nnc(NC(=O)CSc2ccc(Br)cc2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F18 compound treatment 0.385 0.0332 1.7 0.371 0.0215 1.3 2.1179 0.9914 1432583 Bionet1_002116 Fc1cccc(F)c1n2nc(C#N)c(=O)n(Cc3ccc(Cl)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F19 compound treatment 0.354 0.00216 0.11 0.361 0.0115 0.7 0.5702 0.809 1909232 Bionet1_002117 FC(F)(F)c1nnc(NC(=O)CSc2ccc(Cl)cc2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F20 compound treatment 0.352 1.56E-4 0.01 0.35 5.31E-4 0.03 0.0283 0.8571 1909233 Bionet1_002118 FC(F)(F)c1cccc(c1)C(=O)Nc2nc(cs2)c3sccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F21 compound treatment 0.361 0.00916 0.47 0.353 0.00353 0.21 0.4818 0.9366 1909234 Bionet1_002119 FC(F)(F)c1nnc(NC(=O)CSc2ccccc2Cl)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F22 compound treatment 0.357 0.00516 0.26 0.349 -4.69E-4 -0.03 0.1664 0.6276 1322477 Bionet1_002120 Cc1ccc(cc1)S(=O)(=O)CCNC(=O)Cc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F23 positive control 0.089 -0.263 -13.44 0.085 -0.264 -15.97 -20.7927 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 F24 positive control 0.093 -0.259 -13.24 0.092 -0.257 -15.54 -20.3493 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G01 mock treatment 0.341 -0.0108 -0.55 0.347 -0.00247 -0.15 -0.4975 -0.8664 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G02 mock treatment 0.351 -8.44E-4 -0.04 0.35 5.31E-4 0.03 -0.0078 -0.1456 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G03 compound treatment 0.348 -0.00384 -0.2 0.366 0.0165 1.0 0.5667 0.5571 1909235 Bionet1_002121 FC(F)(F)c1cccc(CN2N=C(CCC2=O)/C=C/c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G04 compound treatment 0.352 1.56E-4 0.01 0.351 0.00153 0.09 0.071 0.7654 1239262 Bionet1_002122 COC(=O)C1CSC(N1C(=O)Nc2ccc(Cl)cc2)C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G05 compound treatment 0.365 0.0132 0.67 0.357 0.00753 0.45 0.7972 0.9818 1909236 Bionet1_002123 Clc1ccc(CN2N=C(CCC2=O)/C=C/c3ccccc3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G06 compound treatment 0.338 -0.0138 -0.71 0.338 -0.0115 -0.69 -0.9901 -0.9999 1909237 Bionet1_002124 COc1ccc(cc1)S(=O)(=O)NN(C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G07 compound treatment 0.389 0.0372 1.9 0.373 0.0235 1.42 2.3479 0.9897 1909238 Bionet1_002125 CC(C)c1ccc(/C=C/C2=NN(Cc3cccc(c3)C(F)(F)F)C(=O)CC2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G08 compound treatment 0.341 -0.0108 -0.55 0.338 -0.0115 -0.69 -0.8816 -0.9939 1489822 Bionet1_002126 COC(=O)C1CSC(N1C(=O)Nc2ccc(Cl)c(Cl)c2)C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G09 compound treatment 0.409 0.0572 2.92 0.398 0.0485 2.93 4.1382 1.0 1909239 Bionet1_002127 Cc1ccc(/C=C/C2=NN(Cc3ccc(Cl)c(Cl)c3)C(=O)CC2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G10 compound treatment 0.521 0.169 8.65 0.503 0.154 9.27 12.6698 0.9994 1909240 Bionet1_002128 CC(=O)C1=NOC2COC3(CCN(CC3)c4ccc(cc4)[N+](=O)[O-])OCC21 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G11 compound treatment 0.348 -0.00384 -0.2 0.363 0.0135 0.82 0.4386 0.5221 1428207 Bionet1_002129 Cc1ccc(Sc2ccc(C#N)cc2NC(=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G12 compound treatment 0.344 -0.00784 -0.4 0.346 -0.00347 -0.21 -0.4317 -0.9541 1485122 Bionet1_002130 COC(=O)C1SCC2N1C(=O)CN(Cc3ccc(Cl)cc3)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G13 compound treatment 0.349 -0.00284 -0.15 0.345 -0.00447 -0.27 -0.2936 -0.9579 1281515 Bionet1_002131 Cc1ccc(Sc2ccc(C#N)cc2NC(=O)c3ccccc3C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G14 compound treatment 0.342 -0.00984 -0.5 0.345 -0.00447 -0.27 -0.5467 -0.9573 1909241 Bionet1_002132 COC(=O)c1ccccc1N/C=C/c2nccc3c2cnc4c(C#N)cnn43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G15 compound treatment 0.355 0.00316 0.16 0.356 0.00653 0.39 0.3929 0.9223 1185688 Bionet1_002133 Cc1ccc(Sc2ccc(C#N)cc2NC(=O)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G16 compound treatment 0.345 -0.00684 -0.35 0.357 0.00753 0.45 0.074 0.1291 1909242 Bionet1_002134 CCOC(=O)/C(=C\N(C)C)/Sc1ncc(cc1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G17 compound treatment 0.361 0.00916 0.47 0.366 0.0165 1.0 1.0367 0.9405 1247894 Bionet1_002135 COc1cccc(c1)C(=O)Nc2cc(C#N)ccc2Sc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G18 compound treatment 0.368 0.0162 0.83 0.362 0.0125 0.76 1.1191 0.999 1590978 Bionet1_002136 CCOC(=O)CN1C(=C(C(CC1=O)c2ccc(Cl)cc2)C(=O)OCC)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G19 compound treatment 0.353 0.00116 0.06 0.35 5.31E-4 0.03 0.0645 0.9587 1527802 Bionet1_002137 Clc1ccc(Sc2ccc(C#N)cc2NC(=O)c3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G20 compound treatment 0.344 -0.00784 -0.4 0.35 5.31E-4 0.03 -0.2609 -0.6485 1909243 Bionet1_002138 COc1ccc(OC)c(N/C=C/c2nccc3c2cnc4c(C#N)cnn43)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G21 compound treatment 0.348 -0.00384 -0.2 0.345 -0.00447 -0.27 -0.3297 -0.9879 1556695 Bionet1_002139 Clc1ccc(Sc2ccc(C#N)cc2NC(=O)c3ccc(Cl)nc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G22 compound treatment 0.362 0.0102 0.52 0.37 0.0205 1.24 1.2436 0.9254 1909244 Bionet1_002140 FC(F)(F)c1ccc(N/C=C/c2nccc3c2cnc4c(C#N)cnn43)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G23 positive control 0.091 -0.261 -13.34 0.088 -0.261 -15.78 -20.5924 -0.9965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 G24 positive control 0.096 -0.256 -13.08 0.094 -0.255 -15.42 -20.1555 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H01 mock treatment 0.354 0.00216 0.11 0.355 0.00553 0.33 0.3141 0.8932 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H02 mock treatment 0.364 0.0122 0.62 0.356 0.00653 0.39 0.7183 0.9759 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H03 compound treatment 0.355 0.00316 0.16 0.358 0.00853 0.52 0.4783 0.8862 1909245 Bionet1_002141 FC(F)(F)c1nnc(NC(=O)CSc2cccc(Cl)c2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H04 compound treatment 0.367 0.0152 0.77 0.363 0.0135 0.82 1.1256 0.9997 1909246 Bionet1_002142 Cc1ccc(CC(=O)NCCSc2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H05 compound treatment 0.386 0.0342 1.75 0.375 0.0255 1.54 2.3248 0.9981 1909247 Bionet1_002143 FC(F)(F)c1nnc(NC(=O)CSc2cccc(Cl)c2Cl)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H06 compound treatment 0.348 -0.00384 -0.2 0.357 0.00753 0.45 0.1825 0.3685 1694109 Bionet1_002144 Clc1ccc(CC(=O)NCCS(=O)(=O)c2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H07 compound treatment 0.377 0.0252 1.29 0.365 0.0155 0.94 1.5725 0.9879 1909248 Bionet1_002145 COC(=O)c1ccccc1SCC(=O)Nc2nnc(s2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H08 compound treatment 0.343 -0.00884 -0.45 0.339 -0.0105 -0.63 -0.7666 -0.9865 1217604 Bionet1_002146 Cc1ccc(CC(=O)NCCS(=O)c2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H09 compound treatment 0.348 -0.00384 -0.2 0.35 5.31E-4 0.03 -0.1163 -0.584 1909249 Bionet1_002147 COc1ccc(cc1)S(=O)(=O)CC(=O)Nc2nnc(s2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H10 compound treatment 0.358 0.00616 0.31 0.351 0.00153 0.09 0.2879 0.8777 1411721 Bionet1_002148 Cc1ccc(CC(=O)NCCS(=O)(=O)c2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H11 compound treatment 0.346 -0.00584 -0.3 0.348 -0.00147 -0.09 -0.274 -0.879 1909250 Bionet1_002149 FC(F)(F)c1nnc(NC(=O)CS(=O)(=O)c2cccc(Cl)c2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H12 compound treatment 0.37 0.0182 0.93 0.374 0.0245 1.48 1.7036 0.9747 1909251 Bionet1_002150 Cc1ccc(Oc2ncccc2/C=N/OCc3ccc(Cl)cc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H13 compound treatment 0.356 0.00416 0.21 0.36 0.0105 0.64 0.5998 0.8948 1909252 Bionet1_002151 Cc1ccc(cc1)S(=O)(=O)CC(=O)Nc2nnc(s2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H14 compound treatment 0.377 0.0252 1.29 0.385 0.0355 2.14 2.4263 0.9701 1909253 Bionet1_002152 Cc1ccc(Oc2ncccc2/C=N/OCc3ccc(Cl)c(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H15 compound treatment 0.37 0.0182 0.93 0.372 0.0225 1.36 1.6182 0.9827 1909254 Bionet1_002153 FC(F)(F)c1nnc(NC(=O)CSc2cc(Cl)ccc2Cl)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H16 compound treatment 0.408 0.0562 2.87 0.407 0.0575 3.47 4.4862 0.9955 1909255 Bionet1_002154 Clc1ccc(CO/N=C/c2cccnc2Sc3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H17 compound treatment 0.368 0.0162 0.83 0.365 0.0155 0.94 1.2471 0.998 1909256 Bionet1_002155 CCOC(=O)c1nnc(nc1Sc2ccc(OC)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H18 compound treatment 0.372 0.0202 1.03 0.367 0.0175 1.06 1.4771 0.9999 1909257 Bionet1_002156 Clc1ccc(CO/N=C/c2cccnc2Sc3ccccc3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H19 compound treatment 0.358 0.00616 0.31 0.361 0.0115 0.7 0.7148 0.9356 1909258 Bionet1_002157 CCOC(=O)c1nnc(nc1Sc2ccccc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H20 compound treatment 0.359 0.00716 0.37 0.364 0.0145 0.88 0.879 0.9248 1618073 Bionet1_002158 Cc1ccc(Sc2ncccc2COC(=O)Nc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H21 compound treatment 0.354 0.00216 0.11 0.351 0.00153 0.09 0.1433 0.9962 1909259 Bionet1_002159 CCOC(=O)c1nnc(nc1Sc2cc(C)ccc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H22 compound treatment 0.365 0.0132 0.67 0.364 0.0145 0.88 1.096 0.9914 1489075 Bionet1_002160 Cc1ccc(Sc2ncccc2COC(=O)Nc3cccc(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H23 positive control 0.092 -0.26 -13.29 0.088 -0.261 -15.78 -20.5562 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 H24 positive control 0.096 -0.256 -13.08 0.095 -0.254 -15.36 -20.1128 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I01 mock treatment 0.347 -0.00484 -0.25 0.345 -0.00447 -0.27 -0.3659 -0.9991 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I02 mock treatment 0.36 0.00816 0.42 0.352 0.00253 0.15 0.4029 0.9072 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I03 compound treatment 0.39 0.0382 1.95 0.374 0.0245 1.48 2.4267 0.9907 1909260 Bionet1_002161 COc1ccc(NC(=O)/C(=C(/Cl)\SCc2ccccc2)/Cl)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I04 compound treatment 0.357 0.00516 0.26 0.356 0.00653 0.39 0.4652 0.9809 1909261 Bionet1_002162 Ic1ccc(N/C=C/C(=O)c2ccc3ccccc3c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I05 compound treatment 0.36 0.00816 0.42 0.357 0.00753 0.45 0.6164 0.9991 1909262 Bionet1_002163 CC1(C)CN(C1=O)c2ccc(Oc3ncc(cc3Cl)C(F)(F)F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I06 compound treatment 0.341 -0.0108 -0.55 0.332 -0.0175 -1.05 -1.1378 -0.9549 1177842 Bionet1_002164 COC(=O)C(CC(=O)c1ccc(Cl)cc1)c2cccc(Cl)c2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I07 compound treatment 0.352 1.56E-4 0.01 0.336 -0.0135 -0.81 -0.5693 -0.7001 1909263 Bionet1_002165 CC(=C)C(=O)Nc1ccc(Oc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I08 compound treatment 0.345 -0.00684 -0.35 0.331 -0.0185 -1.11 -1.0358 -0.8864 1472974 Bionet1_002166 COC(=O)C(CC(=O)c1ccc(Cl)cc1)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I09 compound treatment 0.365 0.0132 0.67 0.352 0.00253 0.15 0.5837 0.8462 1909264 Bionet1_002167 CC1(C)CN(C1=O)c2ccc(cc2)C(=O)C/C=N/OCc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I10 compound treatment 0.343 -0.00884 -0.45 0.339 -0.0105 -0.63 -0.7666 -0.9865 1570637 Bionet1_002168 COC(=O)C(CC(=O)c1ccc(Cl)cc1)c2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I11 compound treatment 0.368 0.0162 0.83 0.364 0.0145 0.88 1.2044 0.9995 1909265 Bionet1_002169 CC1(C)CN(C1=O)c2ccc(cc2)C(=O)/C=C/c3cccc(Br)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I12 compound treatment 0.352 1.56E-4 0.01 0.35 5.31E-4 0.03 0.0283 0.8571 1909266 Bionet1_002170 Clc1ccc(cc1)C2=NNC(=O)C(C2)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I13 compound treatment 0.361 0.00916 0.47 0.369 0.0195 1.18 1.1648 0.9181 1909267 Bionet1_002171 CC1(C)CN(C1=O)c2cccc(Oc3ncc(cc3Cl)C(F)(F)F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I14 compound treatment 0.362 0.0102 0.52 0.357 0.00753 0.45 0.6887 0.9978 1909268 Bionet1_002172 Clc1ccc(cc1)C2=NNC(=O)C(C2)c3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I15 compound treatment 0.382 0.0302 1.54 0.366 0.0165 1.0 1.796 0.9778 1236270 Bionet1_002173 CC1(C)CN(C1=O)c2ccc(cc2)c3ccnn3c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I16 compound treatment 0.354 0.00216 0.11 0.344 -0.00547 -0.33 -0.1555 -0.4467 1909269 Bionet1_002174 Clc1ccc(cc1)C2CC(=NNC2=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I17 compound treatment 0.36 0.00816 0.42 0.355 0.00553 0.33 0.531 0.9939 1909270 Bionet1_002175 C(Sc1ccccc1)c2cc(nc(n2)c3ccccc3)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I18 compound treatment 0.356 0.00416 0.21 0.356 0.00653 0.39 0.4291 0.9579 1909271 Bionet1_002176 Clc1ccc(cc1)C2CC(=NNC2=O)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I19 compound treatment 0.336 -0.0158 -0.81 0.342 -0.00747 -0.45 -0.8917 -0.9617 1909272 Bionet1_002177 CSc1cc(CSc2ccc(Cl)cc2)nc(n1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I20 compound treatment 0.345 -0.00684 -0.35 0.34 -0.00947 -0.57 -0.6516 -0.9723 1909273 Bionet1_002178 Clc1ccc(cc1)C2=NNC(=O)C(C2)c3cccc(Br)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I21 compound treatment 0.341 -0.0108 -0.55 0.35 5.31E-4 0.03 -0.3694 -0.6651 1909274 Bionet1_002179 CSc1cc(CS(=O)(=O)c2ccccc2)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I22 compound treatment 0.38 0.0282 1.44 0.364 0.0145 0.88 1.6383 0.9718 1909275 Bionet1_002180 FC(F)(F)c1cnc(c(Cl)c1)n2cc(c3c[nH][nH]c3=O)c4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I23 positive control 0.092 -0.26 -13.29 0.089 -0.26 -15.72 -20.5135 -0.9965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 I24 positive control 0.095 -0.257 -13.13 0.096 -0.253 -15.3 -20.1062 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J01 mock treatment 0.345 -0.00684 -0.35 0.347 -0.00247 -0.15 -0.3528 -0.9276 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J02 mock treatment 0.354 0.00216 0.11 0.358 0.00853 0.52 0.4421 0.8395 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J03 compound treatment 0.368 0.0162 0.83 0.373 0.0235 1.42 1.5886 0.9667 1909276 Bionet1_002181 CCOC(=O)c1nnc(nc1Sc2ccccc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J04 compound treatment 0.365 0.0132 0.67 0.353 0.00353 0.21 0.6264 0.8877 1405036 Bionet1_002182 Cc1ccc(Sc2ncccc2COC(=O)NC3CCCCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J05 compound treatment 0.36 0.00816 0.42 0.357 0.00753 0.45 0.6164 0.9991 1909277 Bionet1_002183 CCOC(=O)c1nnc(nc1Sc2ccc(C)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J06 compound treatment 0.356 0.00416 0.21 0.346 -0.00347 -0.21 0.0022 0.0074 1459348 Bionet1_002184 Cc1ccc(Sc2ncccc2COC(=O)Nc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J07 compound treatment 0.359 0.00716 0.37 0.365 0.0155 0.94 0.9217 0.9158 1909278 Bionet1_002185 CCOC(=O)c1nnc(nc1Sc2ccc(F)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J08 compound treatment 0.353 0.00116 0.06 0.358 0.00853 0.52 0.406 0.7831 1626986 Bionet1_002186 Clc1ccc(NC(=O)c2ccccc2Sc3ccccc3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J09 compound treatment 0.37 0.0182 0.93 0.374 0.0245 1.48 1.7036 0.9747 1909279 Bionet1_002187 CCOC(=O)c1nnc(nc1Sc2ccccc2C(=O)OC)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J10 compound treatment 0.353 0.00116 0.06 0.35 5.31E-4 0.03 0.0645 0.9587 1909280 Bionet1_002188 FC(F)(F)c1cccc(NC(=O)c2ccccc2Sc3ccccc3C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J11 compound treatment 0.382 0.0302 1.54 0.39 0.0405 2.45 2.8205 0.9752 1909281 Bionet1_002189 CCOC(=O)c1nnc(nc1Oc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J12 compound treatment 0.342 -0.00984 -0.5 0.335 -0.0145 -0.87 -0.9735 -0.9657 1161119 Bionet1_002190 COc1ccc(NC(=O)c2ccccc2Sc3ccccc3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J13 compound treatment 0.369 0.0172 0.88 0.369 0.0195 1.18 1.454 0.9894 1909282 Bionet1_002191 CCOC(=O)c1nnc(nc1Oc2cccc(c2)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J14 compound treatment 0.356 0.00416 0.21 0.343 -0.00647 -0.39 -0.1259 -0.2831 1222321 Bionet1_002192 Clc1ccc(NC(=O)c2ccccc2S(=O)c3ccccc3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J15 compound treatment 0.355 0.00316 0.16 0.35 5.31E-4 0.03 0.1368 0.8314 1909283 Bionet1_002193 CCOC(=O)c1nnc(nc1Oc2c(Cl)cccc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J16 compound treatment 0.345 -0.00684 -0.35 0.34 -0.00947 -0.57 -0.6516 -0.9723 1703051 Bionet1_002194 Clc1ccc(NC(=O)c2ccccc2S(=O)(=O)c3ccccc3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J17 compound treatment 0.351 -8.44E-4 -0.04 0.357 0.00753 0.45 0.291 0.6371 1909284 Bionet1_002195 CCOC(=O)c1nnc(nc1Oc2ccccc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J18 compound treatment 0.362 0.0102 0.52 0.348 -0.00147 -0.09 0.3045 0.578 1315840 Bionet1_002196 COc1ccc(NC(=O)c2ccccc2S(=O)c3ccccc3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J19 compound treatment 0.351 -8.44E-4 -0.04 0.354 0.00453 0.27 0.1629 0.5883 1909285 Bionet1_002197 CCOC(=O)c1nnc(nc1Oc2ccc(OC)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J20 compound treatment 0.348 -0.00384 -0.2 0.35 5.31E-4 0.03 -0.1163 -0.584 1208169 Bionet1_002198 COc1ccc(NC(=O)c2ccccc2S(=O)(=O)c3ccccc3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J21 compound treatment 0.357 0.00516 0.26 0.351 0.00153 0.09 0.2518 0.9012 1909286 Bionet1_002199 CCOC(=O)c1nnc(nc1Oc2ccccc2)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J22 compound treatment 0.355 0.00316 0.16 0.347 -0.00247 -0.15 0.0087 0.0398 1536537 Bionet1_002200 O=C(Nc1ccccc1)c2ccccc2S(=O)(=O)c3ccccc3C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J23 positive control 0.089 -0.263 -13.44 0.088 -0.261 -15.78 -20.6647 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 J24 positive control 0.095 -0.257 -13.13 0.097 -0.252 -15.24 -20.0636 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K01 mock treatment 0.346 -0.00584 -0.3 0.347 -0.00247 -0.15 -0.3167 -0.9484 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K02 mock treatment 0.346 -0.00584 -0.3 0.362 0.0125 0.76 0.3236 0.3979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K03 compound treatment 0.356 0.00416 0.21 0.353 0.00353 0.21 0.301 1.0 1909287 Bionet1_002201 O=S(=O)(Cc1cc(nc(n1)c2ccccn2)N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K04 compound treatment 0.359 0.00716 0.37 0.346 -0.00347 -0.21 0.1107 0.2625 1909288 Bionet1_002202 NC(=O)Cc1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K05 compound treatment 0.363 0.0112 0.57 0.362 0.0125 0.76 0.9383 0.9903 1137727 Bionet1_002203 O=S(=O)(Cc1cc(nc(n1)c2ccncc2)N3CCCCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K06 compound treatment 0.367 0.0152 0.77 0.366 0.0165 1.0 1.2537 0.9922 1909289 Bionet1_002204 COC(=O)C1CCN(CC1)c2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K07 compound treatment 0.364 0.0122 0.62 0.365 0.0155 0.94 1.1025 0.9801 1240316 Bionet1_002205 C(Sc1ccccc1)c2cc(nc(n2)c3ccncc3)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K08 compound treatment 0.227 -0.125 -6.38 0.227 -0.122 -7.39 -9.7417 -0.9973 1619521 Bionet1_002206 COc1ccc(cc1)C2CC(=O)C(CS(=O)(=O)c3ccccc3)C(=O)C2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K09 compound treatment 0.415 0.0632 3.23 0.403 0.0535 3.23 4.5686 1.0 1163902 Bionet1_002207 Clc1ccc(cc1Cl)C(=O)Nc2ccc(Sc3ccccc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K10 compound treatment 0.329 -0.0228 -1.17 0.323 -0.0265 -1.6 -1.9558 -0.9881 1909290 Bionet1_002208 ClC1=C(CS(=O)(=O)c2ccccc2)C(=O)CC(C1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K11 compound treatment 0.366 0.0142 0.72 0.362 0.0125 0.76 1.0468 0.9998 1909291 Bionet1_002209 FC(F)(F)c1cccc(c1)C(=O)Nc2ccc(Sc3ccccc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K12 compound treatment 0.355 0.00316 0.16 0.349 -4.69E-4 -0.03 0.0941 0.5744 1909292 Bionet1_002210 C/[N+](=C/c1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13)/[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K13 compound treatment 0.372 0.0202 1.03 0.364 0.0145 0.88 1.3491 0.9968 1507420 Bionet1_002211 Clc1ccc(cc1)C(=O)Nc2ccc(Sc3ccccc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K14 compound treatment 0.347 -0.00484 -0.25 0.338 -0.0115 -0.69 -0.6647 -0.904 1909293 Bionet1_002212 NC(=O)C(=O)c1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K15 compound treatment 0.36 0.00816 0.42 0.35 5.31E-4 0.03 0.3176 0.7592 1909294 Bionet1_002213 Clc1ccc(cc1)S(=O)Cc2cc(nc(n2)c3ccccn3)N4CCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K16 compound treatment 0.388 0.0362 1.85 0.381 0.0315 1.9 2.6532 0.9999 1909295 Bionet1_002214 FC(F)(F)c1cnc(c(Cl)c1)n2cc(C=C(C#N)C#N)c3ccccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K17 compound treatment 0.382 0.0302 1.54 0.376 0.0265 1.6 2.2229 0.9998 1723501 Bionet1_002215 Clc1cc(Cl)cc(c1)C(=O)Nc2ccc(Sc3ccccc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K18 compound treatment 0.361 0.00916 0.47 0.36 0.0105 0.64 0.7806 0.9887 1909296 Bionet1_002216 CO/N=C\c1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K19 compound treatment 0.338 -0.0138 -0.71 0.34 -0.00947 -0.57 -0.9047 -0.9944 1909297 Bionet1_002217 Clc1ccc(SCc2cc(nc(n2)c3ccccc3)N4CCCCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K20 compound treatment 0.34 -0.0118 -0.61 0.336 -0.0135 -0.81 -1.0032 -0.9895 1909298 Bionet1_002218 CCOC(=O)/C=C\c1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K21 compound treatment 0.359 0.00716 0.37 0.359 0.00953 0.58 0.6656 0.9761 1287437 Bionet1_002219 Cc1ccc(Sc2ccc(NC(=O)c3ccc(F)cc3)cc2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K22 compound treatment 0.357 0.00516 0.26 0.346 -0.00347 -0.21 0.0384 0.1139 1909299 Bionet1_002220 CC(=O)/C=C\c1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K23 positive control 0.095 -0.257 -13.13 0.09 -0.259 -15.66 -20.3624 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 K24 positive control 0.102 -0.25 -12.78 0.096 -0.253 -15.3 -19.8531 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L01 mock treatment 0.351 -8.44E-4 -0.04 0.348 -0.00147 -0.09 -0.0932 -0.9452 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L02 mock treatment 0.356 0.00416 0.21 0.35 5.31E-4 0.03 0.173 0.8047 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L03 compound treatment 0.368 0.0162 0.83 0.357 0.00753 0.45 0.9056 0.9604 1909300 Bionet1_002221 CCOC(=O)c1nnc(nc1Sc2ccccc2)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L04 compound treatment 0.366 0.0142 0.72 0.36 0.0105 0.64 0.9614 0.9979 1909301 Bionet1_002222 Cc1ccc(CO/N=C\2/c3ccccc3-c4nnc(cc24)c5ccc(C)cc5)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L05 compound treatment 0.392 0.0402 2.05 0.378 0.0285 1.72 2.6698 0.9962 1909302 Bionet1_002223 CCOC(=O)c1nnc(nc1Sc2ccccc2Cl)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L06 compound treatment 0.362 0.0102 0.52 0.361 0.0115 0.7 0.8594 0.9896 1258226 Bionet1_002224 Clc1ccc(cc1)C(=O)c2c[nH]cc2c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L07 compound treatment 0.354 0.00216 0.11 0.35 5.31E-4 0.03 0.1006 0.8765 1909303 Bionet1_002225 CCOC(=O)c1nnc(nc1Sc2cccc(Cl)c2)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L08 compound treatment 0.388 0.0362 1.85 0.385 0.0355 2.14 2.824 0.9973 1909304 Bionet1_002226 Clc1ccc(cc1)C(=O)c2c[nH]cc2c3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L09 compound treatment 0.359 0.00716 0.37 0.362 0.0125 0.76 0.7937 0.9445 1909305 Bionet1_002227 CCOC(=O)c1nnc(nc1Sc2ccc(Cl)cc2)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L10 compound treatment 0.371 0.0192 0.98 0.364 0.0145 0.88 1.3129 0.9985 1909306 Bionet1_002228 Clc1ccc(cc1)C(=O)c2c[nH]cc2c3cccc(Br)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L11 compound treatment 0.364 0.0122 0.62 0.369 0.0195 1.18 1.2732 0.9553 1909307 Bionet1_002229 CCOC(=O)c1nnc(nc1Oc2ccccc2Cl)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L12 compound treatment 0.368 0.0162 0.83 0.353 0.00353 0.21 0.7349 0.8614 1909308 Bionet1_002230 Clc1ccc(cc1)C(=O)c2c[nH]cc2c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L13 compound treatment 0.375 0.0232 1.18 0.377 0.0275 1.66 2.0125 0.9862 1403197 Bionet1_002231 Cn1nc(c(C(O)C#Cc2ccccc2)c1Sc3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L14 compound treatment 0.351 -8.44E-4 -0.04 0.344 -0.00547 -0.33 -0.264 -0.7928 1909309 Bionet1_002232 Clc1ccc(cc1)C(=O)c2c[nH]cc2c3cccc(Cl)c3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L15 compound treatment 0.348 -0.00384 -0.2 0.345 -0.00447 -0.27 -0.3297 -0.9879 1909310 Bionet1_002233 CCCCC#CC(O)c1c(Sc2ccc(C)cc2)n(C)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L16 compound treatment 0.368 0.0162 0.83 0.355 0.00553 0.33 0.8203 0.9206 1291198 Bionet1_002234 COc1ccc(cc1OC)C(=O)c2c[nH]cc2c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L17 compound treatment 0.356 0.00416 0.21 0.352 0.00253 0.15 0.2583 0.9869 1909311 Bionet1_002235 CCCCC#CC(O)c1c(Sc2ccccc2)n(C)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L18 compound treatment 0.351 -8.44E-4 -0.04 0.348 -0.00147 -0.09 -0.0932 -0.9452 1909312 Bionet1_002236 CSCc1cc(Sc2ccc(Cl)cc2)nc(n1)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L19 compound treatment 0.369 0.0172 0.88 0.359 0.00953 0.58 1.0272 0.9791 1909313 Bionet1_002237 Cc1ccc(Sc2c(C(O)c3cccs3)c(nn2C)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L20 compound treatment 0.35 -0.00184 -0.09 0.348 -0.00147 -0.09 -0.1294 -0.9995 1909314 Bionet1_002238 CS(=O)(=O)Cc1cc(Sc2ccc(Cl)cc2)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L21 compound treatment 0.354 0.00216 0.11 0.35 5.31E-4 0.03 0.1006 0.8765 1909315 Bionet1_002239 CCOC(=O)c1nnc(nc1Oc2ccc(OC)cc2)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L22 compound treatment 0.352 1.56E-4 0.01 0.349 -4.69E-4 -0.03 -0.0144 -0.4884 1728928 Bionet1_002240 CSc1cc(c2ccccc2)n(Cc3ccc(Cl)cc3)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L23 positive control 0.09 -0.262 -13.39 0.088 -0.261 -15.78 -20.6285 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 L24 positive control 0.096 -0.256 -13.08 0.097 -0.252 -15.24 -20.0274 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M01 mock treatment 0.352 1.56E-4 0.01 0.35 5.31E-4 0.03 0.0283 0.8571 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M02 mock treatment 0.353 0.00116 0.06 0.351 0.00153 0.09 0.1072 0.9767 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M03 compound treatment 0.406 0.0542 2.77 0.397 0.0475 2.87 3.987 0.9998 1546846 Bionet1_002241 Cc1ccc(Sc2ccc(NC(=O)c3ccccc3C)cc2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M04 compound treatment 0.338 -0.0138 -0.71 0.344 -0.00547 -0.33 -0.734 -0.9397 1909316 Bionet1_002242 [O-][N+](=O)/C=C\c1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M05 compound treatment 0.365 0.0132 0.67 0.354 0.00453 0.27 0.6691 0.9214 1243374 Bionet1_002243 Cc1ccc(Sc2ccc(NC(=O)c3ccccc3Cl)cc2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M06 compound treatment 0.352 1.56E-4 0.01 0.353 0.00353 0.21 0.1564 0.7331 1632338 Bionet1_002244 Clc1ccc(nn1)N2CCC(CC2)C(=O)NCC3CC4CCCCN4O3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M07 compound treatment 0.387 0.0352 1.8 0.38 0.0305 1.84 2.5744 0.9999 1635382 Bionet1_002245 Fc1ccc(cc1)C(=O)Nc2ccc(Sc3ccc(Cl)cc3)c(C#N)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M08 compound treatment 0.359 0.00716 0.37 0.358 0.00853 0.52 0.6229 0.986 1909317 Bionet1_002246 Cc1c(Br)c2ccccc2n1c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M09 compound treatment 0.357 0.00516 0.26 0.355 0.00553 0.33 0.4225 0.9932 1909318 Bionet1_002247 CN(C)c1cc(CS(=O)c2ccc(Cl)cc2)nc(n1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M10 compound treatment 0.355 0.00316 0.16 0.351 0.00153 0.09 0.1795 0.965 1909319 Bionet1_002248 FC(F)(F)c1cnc(c(Cl)c1)n2cc(Br)c3ccccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M11 compound treatment 0.383 0.0312 1.59 0.377 0.0275 1.66 2.3017 0.9998 1449907 Bionet1_002249 Cc1ccccc1Sc2ccc(NC(=O)c3ccc(F)cc3)cc2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M12 compound treatment 0.267 -0.0848 -4.34 0.262 -0.0875 -5.28 -6.8014 -0.9952 1568934 Bionet1_002250 Clc1ccc(cc1)C2CC(=O)C(CS(=O)(=O)c3ccccc3)C(=O)C2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M13 compound treatment 0.379 0.0272 1.39 0.375 0.0255 1.54 2.0717 0.9986 1443702 Bionet1_002251 Cc1ccccc1Sc2ccc(NC(=O)c3ccccc3Cl)cc2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M14 compound treatment 0.38 0.0282 1.44 0.364 0.0145 0.88 1.6383 0.9718 1909320 Bionet1_002252 CN(C)/C=C/C(=O)c1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M15 compound treatment 0.386 0.0342 1.75 0.393 0.0435 2.63 3.0932 0.9803 1154525 Bionet1_002253 Cc1ccccc1Sc2ccc(NC(=O)c3cccc(Cl)c3)cc2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M16 compound treatment 0.349 -0.00284 -0.15 0.347 -0.00247 -0.15 -0.2082 -0.9999 1909321 Bionet1_002254 NNC(=O)Cc1cn(c2ncc(cc2Cl)C(F)(F)F)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M17 compound treatment 0.398 0.0462 2.36 0.387 0.0375 2.27 3.2709 0.9998 1297917 Bionet1_002255 Cc1ccc(Sc2ccc(NC(=O)c3cccc(C)c3)cc2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M18 compound treatment 0.357 0.00516 0.26 0.348 -0.00147 -0.09 0.1237 0.4448 1909322 Bionet1_002256 FC(F)(F)Oc1ccc(N/C=C\2/CCN(C2=O)c3ncccn3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M19 compound treatment 0.378 0.0262 1.34 0.375 0.0255 1.54 2.0356 0.9975 1229272 Bionet1_002257 COc1ccc(Sc2ccc(NC(=O)c3ccccc3Cl)cc2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M20 compound treatment 0.356 0.00416 0.21 0.351 0.00153 0.09 0.2156 0.9305 1909323 Bionet1_002258 COc1ccc(/C=C(\C#N)/c2ccc(s2)C(=O)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M21 compound treatment 0.361 0.00916 0.47 0.361 0.0115 0.7 0.8233 0.9814 1643147 Bionet1_002259 COc1ccc(Sc2ccc(NC(=O)c3c(F)cccc3F)cc2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M22 compound treatment 0.358 0.00616 0.31 0.358 0.00853 0.52 0.5868 0.9721 1909324 Bionet1_002260 COc1ccc(/C=C(\C#N)/c2ccc(s2)C(=O)c3ccc(OC)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M23 positive control 0.09 -0.262 -13.39 0.091 -0.258 -15.6 -20.5005 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 M24 positive control 0.095 -0.257 -13.13 0.096 -0.253 -15.3 -20.1062 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N01 mock treatment 0.353 0.00116 0.06 0.345 -0.00447 -0.27 -0.149 -0.5393 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N02 mock treatment 0.35 -0.00184 -0.09 0.354 0.00453 0.27 0.1268 0.4381 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N03 compound treatment 0.413 0.0612 3.13 0.398 0.0485 2.93 4.2828 0.9995 1909325 Bionet1_002261 Brc1ccc(Sc2nc3ccccc3cc2c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N04 compound treatment 0.373 0.0212 1.08 0.362 0.0125 0.76 1.2998 0.9847 1909326 Bionet1_002262 CSc1cc(c2ccccc2)n(Cc3cccc(c3)C(F)(F)F)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N05 compound treatment 0.385 0.0332 1.7 0.379 0.0295 1.78 2.4594 0.9997 1909327 Bionet1_002263 Clc1ccc(Sc2nc3ccccc3cc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N06 compound treatment 0.379 0.0272 1.39 0.39 0.0405 2.45 2.712 0.964 1703342 Bionet1_002264 CSc1cc(c2ccccc2)n(Cc3ccc(cc3)C(C)(C)C)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N07 compound treatment 0.41 0.0582 2.97 0.397 0.0475 2.87 4.1317 0.9998 1460201 Bionet1_002265 Fc1ccc(Sc2nc3ccccc3cc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N08 compound treatment 0.407 0.0552 2.82 0.388 0.0385 2.33 3.639 0.9954 1144549 Bionet1_002266 CSc1cc(c2ccc(Cl)cc2)n(Cc3ccc(F)cc3)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N09 compound treatment 0.387 0.0352 1.8 0.374 0.0245 1.48 2.3183 0.9954 1629546 Bionet1_002267 COc1ccc(Sc2nc3ccccc3cc2c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N10 compound treatment 0.366 0.0142 0.72 0.356 0.00653 0.39 0.7906 0.9592 1450985 Bionet1_002268 CSc1cc(c2ccc(Cl)cc2)n(Cc3ccc(C)cc3)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N11 compound treatment 0.415 0.0632 3.23 0.396 0.0465 2.81 4.2698 0.9976 1909328 Bionet1_002269 Clc1ccc(cc1)c2cc3ccccc3nc2Sc4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N12 compound treatment 0.365 0.0132 0.67 0.371 0.0215 1.3 1.3948 0.953 1208224 Bionet1_002270 CSc1cc(c2ccc(Cl)cc2)n(Cc3ccccc3C)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N13 compound treatment 0.407 0.0552 2.82 0.399 0.0495 2.99 4.1086 0.9996 1909329 Bionet1_002271 Clc1ccc(cc1)c2cc3ccccc3nc2Sc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N14 compound treatment 0.366 0.0142 0.72 0.35 5.31E-4 0.03 0.5345 0.7377 1119335 Bionet1_002272 CSc1cc(c2ccc(Cl)cc2)n(Cc3ccccc3)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N15 compound treatment 0.373 0.0212 1.08 0.367 0.0175 1.06 1.5133 0.9999 1909330 Bionet1_002273 Clc1ccc(Cl)c(Sc2nc3ccccc3cc2c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N16 compound treatment 0.382 0.0302 1.54 0.375 0.0255 1.54 2.1802 1.0 1479016 Bionet1_002274 CCOC(=O)Cn1c(cc(SC)c(C#N)c1=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N17 compound treatment 0.393 0.0412 2.1 0.393 0.0435 2.63 3.3463 0.9939 1909331 Bionet1_002275 Clc1ccc(Sc2nc3ccccc3cc2c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N18 compound treatment 0.374 0.0222 1.13 0.371 0.0215 1.3 1.7202 0.9977 1173778 Bionet1_002276 CSc1cc(c2ccccc2)n(Cc3cccc(F)c3)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N19 compound treatment 0.343 -0.00884 -0.45 0.34 -0.00947 -0.57 -0.7239 -0.9933 1909332 Bionet1_002277 Cc1ccc(cc1)c2cc3ccccc3nc2Sc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N20 compound treatment 0.352 1.56E-4 0.01 0.344 -0.00547 -0.33 -0.2278 -0.6898 1523934 Bionet1_002278 CSc1cc(c2ccccc2)n(Cc3ccccc3Cl)c(=O)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N21 compound treatment 0.349 -0.00284 -0.15 0.353 0.00353 0.21 0.0479 0.1857 1909333 Bionet1_002279 Cc1ccc(cc1)c2cc3ccccc3nc2Sc4c(Cl)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N22 compound treatment 0.347 -0.00484 -0.25 0.344 -0.00547 -0.33 -0.4086 -0.99 1909334 Bionet1_002280 CC(Sc1ncc(cc1Cl)C(F)(F)F)c2ccnc3c(C#N)cnn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N23 positive control 0.09 -0.262 -13.39 0.09 -0.259 -15.66 -20.5431 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 N24 positive control 0.097 -0.255 -13.03 0.095 -0.254 -15.36 -20.0766 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O01 mock treatment 0.356 0.00416 0.21 0.355 0.00553 0.33 0.3864 0.9762 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O02 mock treatment 0.357 0.00516 0.26 0.353 0.00353 0.21 0.3372 0.9944 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O03 compound treatment 0.374 0.0222 1.13 0.361 0.0115 0.7 1.2933 0.9727 1567916 Bionet1_002281 Cc1ccc(cc1)S(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O04 compound treatment 0.364 0.0122 0.62 0.365 0.0155 0.94 1.1025 0.9801 1909335 Bionet1_002282 CN(C)c1ccc(/C=C(\C#N)/c2ccc(s2)C(=O)c3ccccc3F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O05 compound treatment 0.396 0.0442 2.26 0.385 0.0355 2.14 3.1132 0.9997 1677425 Bionet1_002283 Cc1ccc(cc1)S(=O)(=O)c2ccc(NC(=O)c3ccccc3C)cc2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O06 compound treatment 0.454 0.102 5.22 0.46 0.111 6.67 8.4118 0.9927 1909336 Bionet1_002284 Cc1ccsc1/C=C(\C#N)/c2ccc(s2)C(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O07 compound treatment 0.383 0.0312 1.59 0.367 0.0175 1.06 1.8748 0.9803 1909337 Bionet1_002285 CC(C)c1ccc(/C=C/c2ccc(=O)n(Cc3cccc(c3)C(F)(F)F)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O08 compound treatment 0.345 -0.00684 -0.35 0.358 0.00853 0.52 0.1167 0.1875 1909338 Bionet1_002286 Fc1ccc(cc1)C(=O)c2ccc(s2)/C(=C/c3ccc(Cl)cc3)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O09 compound treatment 0.356 0.00416 0.21 0.358 0.00853 0.52 0.5144 0.9234 1909339 Bionet1_002287 Cc1ccc(/C=C/c2ccc(=O)n(Cc3ccc(cc3)C(C)(C)C)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O10 compound treatment 0.355 0.00316 0.16 0.357 0.00753 0.45 0.4356 0.9029 1909340 Bionet1_002288 Fc1ccccc1C(=O)c2ccc(s2)/C(=C/c3ccc(Cl)cc3)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O11 compound treatment 0.356 0.00416 0.21 0.355 0.00553 0.33 0.3864 0.9762 1909341 Bionet1_002289 Cc1ccc(/C=C/c2ccc(=O)n(Cc3ccc(Cl)cc3Cl)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O12 compound treatment 0.374 0.0222 1.13 0.367 0.0175 1.06 1.5494 0.9994 1909342 Bionet1_002290 FC(F)(F)c1cnc(Oc2ccc(NC(=O)CCCCl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O13 compound treatment 0.356 0.00416 0.21 0.346 -0.00347 -0.21 0.0022 0.0074 1313798 Bionet1_002291 COC(=O)c1cc(C#N)c(NCc2ccc(Cl)cc2Cl)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O14 compound treatment 0.349 -0.00284 -0.15 0.344 -0.00547 -0.33 -0.3363 -0.9321 1909343 Bionet1_002292 FC(F)(F)c1cnc(Oc2cccc(NC(=O)CCCCl)c2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O15 compound treatment 0.369 0.0172 0.88 0.368 0.0185 1.12 1.4113 0.9928 1354365 Bionet1_002293 CCOC(=O)c1cc(C#N)c(Sc2ccccc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O16 compound treatment 0.356 0.00416 0.21 0.354 0.00453 0.27 0.3437 0.9922 1909344 Bionet1_002294 Cc1ccc(cc1)n2cc(c(n2)C(F)(F)F)c3ccc4ccccc4c3[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O17 compound treatment 0.364 0.0122 0.62 0.357 0.00753 0.45 0.761 0.9882 1909345 Bionet1_002295 CCOC(=O)c1cc(C#N)c(Sc2ccc(Cl)cc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O18 compound treatment 0.355 0.00316 0.16 0.354 0.00453 0.27 0.3075 0.9683 1625467 Bionet1_002296 CCOC(=O)c1sc(NC(=O)Nc2ccccc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O19 compound treatment 0.357 0.00516 0.26 0.349 -4.69E-4 -0.03 0.1664 0.6276 1305867 Bionet1_002297 CCOC(=O)c1cc(C#N)c(Sc2ccc(OC)cc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O20 compound treatment 0.361 0.00916 0.47 0.358 0.00853 0.52 0.6952 0.9989 1909346 Bionet1_002298 CCOC(=O)C(=CNc1nc(cs1)c2ccc(Cl)cc2)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O21 compound treatment 0.351 -8.44E-4 -0.04 0.351 0.00153 0.09 0.0349 0.3417 1909347 Bionet1_002299 FC(F)(F)c1cccc(Cn2nc(/C=C/c3ccccc3)ccc2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O22 compound treatment 0.359 0.00716 0.37 0.355 0.00553 0.33 0.4949 0.999 1909348 Bionet1_002300 Cc1ccc(SCc2ccc(CSc3ccc(C)cc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O23 positive control 0.091 -0.261 -13.34 0.091 -0.258 -15.6 -20.4643 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 O24 positive control 0.094 -0.258 -13.18 0.094 -0.255 -15.42 -20.2278 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P01 mock treatment 0.36 0.00816 0.42 0.356 0.00653 0.39 0.5737 0.9996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P02 mock treatment 0.361 0.00916 0.47 0.357 0.00753 0.45 0.6525 0.9999 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P03 compound treatment 0.374 0.0222 1.13 0.348 -0.00147 -0.09 0.7384 0.6498 1909349 Bionet1_002301 Cc1ccc(cc1)c2cc3ccccc3nc2Sc4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P04 compound treatment 0.366 0.0142 0.72 0.367 0.0175 1.06 1.2602 0.9828 1159528 Bionet1_002302 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3NC2c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P05 compound treatment 0.364 0.0122 0.62 0.371 0.0215 1.3 1.3586 0.943 1909350 Bionet1_002303 Cc1ccc(cc1)c2cc3ccccc3nc2Sc4cccc(c4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P06 compound treatment 0.354 0.00216 0.11 0.367 0.0175 1.06 0.8263 0.7766 1909351 Bionet1_002304 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3NC2c4ccc(Cl)cc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P07 compound treatment 0.36 0.00816 0.42 0.358 0.00853 0.52 0.6591 0.9945 1663387 Bionet1_002305 CC1CN(CC(C)O1)c2nc3ccccc3cc2c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P08 compound treatment 0.365 0.0132 0.67 0.366 0.0165 1.0 1.1813 0.9816 1081417 Bionet1_002306 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3NC2c4ccc(cc4)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P09 compound treatment 0.371 0.0192 0.98 0.382 0.0325 1.96 2.0813 0.9484 1909352 Bionet1_002307 FC(F)(F)c1cccc(c1)c2cc3ccccc3nc2N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P10 compound treatment 0.367 0.0152 0.77 0.366 0.0165 1.0 1.2537 0.9922 1572032 Bionet1_002308 Cc1cc2NC(C3=C(CCCC3=O)Nc2cc1C)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P11 compound treatment 0.346 -0.00584 -0.3 0.345 -0.00447 -0.27 -0.402 -0.9987 1909353 Bionet1_002309 Fc1ccc(OCc2ncc(cn2)c3ncc(cc3Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P12 compound treatment 0.374 0.0222 1.13 0.365 0.0155 0.94 1.4641 0.9956 1462066 Bionet1_002310 Cc1cc2NC(C3=C(CCCC3=O)Nc2cc1C)c4ccc(Br)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P13 compound treatment 0.357 0.00516 0.26 0.356 0.00653 0.39 0.4652 0.9809 1486895 Bionet1_002311 Clc1ccc(CN2CCC(CC2)c3cc([nH]n3)c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P14 compound treatment 0.368 0.0162 0.83 0.375 0.0255 1.54 1.674 0.9573 1909354 Bionet1_002312 Cc1cc2NC(C3=C(CCCC3=O)Nc2cc1C)c4ccc(cc4)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P15 compound treatment 0.356 0.00416 0.21 0.351 0.00153 0.09 0.2156 0.9305 1652067 Bionet1_002313 CCOC(=O)c1cnc2c(cc(Cl)cc2c1O)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P16 compound treatment 0.364 0.0122 0.62 0.369 0.0195 1.18 1.2732 0.9553 1187202 Bionet1_002314 Cc1cc2NC(C3=C(CCCC3=O)Nc2cc1C)c4cccc(Br)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P17 compound treatment 0.393 0.0412 2.1 0.392 0.0425 2.57 3.3036 0.9951 1909355 Bionet1_002315 FC(F)(F)c1cnc(c(Cl)c1)C(C#N)(N2CCOCC2)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P18 compound treatment 0.376 0.0242 1.24 0.357 0.00753 0.45 1.1949 0.9078 1303113 Bionet1_002316 Cc1ccc(cc1)C2Nc3cc(C)c(C)cc3NC4=C2C(=O)CC(C)(C)C4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P19 compound treatment 0.344 -0.00784 -0.4 0.338 -0.0115 -0.69 -0.7732 -0.9663 1909356 Bionet1_002317 [O-][N+](=O)c1ccc(CN2CCC(CC2)c3cc([nH]n3)c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P20 compound treatment 0.353 0.00116 0.06 0.349 -4.69E-4 -0.03 0.0218 0.3325 1909357 Bionet1_002318 C/C(=N\Nc1ccc(OC(F)(F)F)cc1)/C(=N/O)/C(=O)Nc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P21 compound treatment 0.346 -0.00584 -0.3 0.352 0.00253 0.15 -0.1032 -0.3076 1909358 Bionet1_002319 FC(F)(F)c1cc(N/N=C\2/C(=O)OC(=O)c3ccccc23)ccc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P22 compound treatment 0.356 0.00416 0.21 0.358 0.00853 0.52 0.5144 0.9234 1563610 Bionet1_002320 COc1ccc(cc1)C2Nc3cc(C)c(C)cc3NC4=C2C(=O)CC(C)(C)C4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P23 positive control 0.092 -0.26 -13.29 0.091 -0.258 -15.6 -20.4281 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.574 P24 positive control 0.095 -0.257 -13.13 0.096 -0.253 -15.3 -20.1062 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A01 mock treatment 0.322 -0.0297 -1.52 0.331 -0.0287 -1.73 -2.2987 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A02 mock treatment 0.325 -0.0267 -1.37 0.329 -0.0307 -1.85 -2.2756 -0.9888 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A03 compound treatment 0.329 -0.0227 -1.16 0.333 -0.0267 -1.61 -1.9602 -0.9871 1909359 Bionet1_002321 Fc1ccccc1CO/N=C/CC(=O)c2cnc(s2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A04 compound treatment 0.323 -0.0287 -1.47 0.334 -0.0257 -1.55 -2.1344 -0.9996 1909360 Bionet1_002322 CC1=C(C(NC(=S)N1)c2ccc(Cl)cc2)C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A05 compound treatment 0.337 -0.0147 -0.75 0.338 -0.0217 -1.31 -1.4575 -0.9655 1909361 Bionet1_002323 COc1ccc(cc1)S(=O)(=O)n2ccc(n2)c3cnc(s3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A06 compound treatment 0.326 -0.0257 -1.32 0.337 -0.0227 -1.37 -1.8979 -0.9998 1909362 Bionet1_002324 CC1=C(C(NC(=S)N1)c2c(F)cccc2Cl)C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A07 compound treatment 0.326 -0.0257 -1.32 0.339 -0.0207 -1.25 -1.8125 -0.9997 1909363 Bionet1_002325 O=S(=O)(c1cccs1)n2ccc(n2)c3cnc(s3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A08 compound treatment 0.326 -0.0257 -1.32 0.346 -0.0137 -0.83 -1.5137 -0.9749 1909364 Bionet1_002326 CC1=C(C(N2C(=O)CSC2=N1)c3ccc(Cl)cc3)C(=O)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A09 compound treatment 0.323 -0.0287 -1.47 0.338 -0.0217 -1.31 -1.9637 -0.9983 1909365 Bionet1_002327 O=S(=O)(c1ccccc1)n2ccc(n2)c3cnc(s3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A10 compound treatment 0.334 -0.0177 -0.91 0.354 -0.00568 -0.34 -0.883 -0.9116 1452419 Bionet1_002328 CCOC(=O)C1=C(C)NC2=C(C1c3ccc(OC)cc3)C(=O)CC(C)(C)C2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A11 compound treatment 0.323 -0.0287 -1.47 0.35 -0.00968 -0.58 -1.4515 -0.9184 1909366 Bionet1_002329 Fc1ccc(cc1)S(=O)(=O)n2ccc(n2)c3cnc(s3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A12 compound treatment 0.339 -0.0127 -0.65 0.355 -0.00468 -0.28 -0.6595 -0.9302 1228507 Bionet1_002330 CCOC(=O)c1c(C)nc2CC(C)(C)CC(=O)c2c1c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A13 compound treatment 0.323 -0.0287 -1.47 0.35 -0.00968 -0.58 -1.4515 -0.9184 1743309 Bionet1_002331 COc1ccc(cc1)C(=O)n2ccc(n2)c3cnc(s3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A14 compound treatment 0.321 -0.0307 -1.57 0.344 -0.0157 -0.95 -1.7799 -0.9706 1909367 Bionet1_002332 CN(C)/C=C(\c1ccc(Cl)cc1)/S(=O)(=O)\C=C\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A15 compound treatment 0.326 -0.0257 -1.32 0.337 -0.0227 -1.37 -1.8979 -0.9998 1909368 Bionet1_002333 FC(F)(F)c1ccc(Oc2ccc(NC(=O)C3CC3)cc2Cl)nc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A16 compound treatment 0.32 -0.0317 -1.62 0.341 -0.0187 -1.13 -1.9441 -0.9842 1909369 Bionet1_002334 COc1ccc(/C=C/C(=O)NC(=S)Nc2ccc(F)cc2C)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A17 compound treatment 0.327 -0.0247 -1.26 0.334 -0.0257 -1.55 -1.9898 -0.9949 1909370 Bionet1_002335 Cc1c(sc(C#N)c1c2ccccc2)C(=O)N/C=N/OCc3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A18 compound treatment 0.325 -0.0267 -1.37 0.326 -0.0337 -2.03 -2.4036 -0.9813 1909371 Bionet1_002336 Cc1ccc(cc1)c2nc(ncc2N=Nc3cccc(C)c3C)c4ccncc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A19 compound treatment 0.326 -0.0257 -1.32 0.344 -0.0157 -0.95 -1.5991 -0.987 1909372 Bionet1_002337 COc1cc(NC(=O)c2ccccc2CC[N+](=O)[O-])cc(OC)c1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A20 compound treatment 0.324 -0.0277 -1.42 0.331 -0.0287 -1.73 -2.2263 -0.9951 1909373 Bionet1_002338 CCOC(=O)C1=C(NC2=C(C1c3ccc(F)cc3)C(=O)CCC2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A21 compound treatment 0.302 -0.0497 -2.54 0.308 -0.0517 -3.12 -4.0036 -0.9948 1909374 Bionet1_002339 [O-][N+](=O)CCc1ccccc1NC(=O)N2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A22 compound treatment 0.324 -0.0277 -1.42 0.332 -0.0277 -1.67 -2.1837 -0.9966 1909375 Bionet1_002340 O=c1n(c(SCc2ccccc2)nc3ccsc13)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A23 positive control 0.085 -0.267 -13.64 0.088 -0.272 -16.4 -21.2406 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 A24 positive control 0.088 -0.264 -13.48 0.094 -0.266 -16.04 -20.876 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B01 mock treatment 0.363 0.0113 0.58 0.353 -0.00668 -0.4 0.1228 0.1746 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B02 mock treatment 0.366 0.0143 0.73 0.365 0.00532 0.32 0.7436 0.932 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B03 compound treatment 0.36 0.00828 0.42 0.366 0.00632 0.38 0.5693 0.9987 1909376 Bionet1_002341 CS(=O)c1ccccc1c2nc(no2)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B04 compound treatment 0.374 0.0223 1.14 0.374 0.0143 0.86 1.417 0.9907 1909377 Bionet1_002342 Clc1ccc(Cn2nc(/C=C/c3ccccc3)ccc2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B05 compound treatment 0.355 0.00328 0.17 0.363 0.00332 0.2 0.2605 0.9961 1909378 Bionet1_002343 CS(=O)(=O)c1ccccc1c2nc(no2)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B06 compound treatment 0.366 0.0143 0.73 0.364 0.00432 0.26 0.7009 0.9038 1909379 Bionet1_002344 CCOC(=O)c1cc(C#N)c(Sc2ccccc2Cl)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B07 compound treatment 0.363 0.0113 0.58 0.359 -6.77E-4 -0.04 0.379 0.6553 1503315 Bionet1_002345 CC(C)(C)c1ccc(cc1)c2noc(n2)c3ccccc3S(=O)(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B08 compound treatment 0.359 0.00728 0.37 0.37 0.0103 0.62 0.7039 0.9697 1135151 Bionet1_002346 CCOC(=O)c1cc(C#N)c(Oc2cc(C)cc(C)c2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B09 compound treatment 0.366 0.0143 0.73 0.366 0.00632 0.38 0.7862 0.9542 1909380 Bionet1_002347 CS(=O)c1ccccc1c2nc(no2)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B10 compound treatment 0.366 0.0143 0.73 0.366 0.00632 0.38 0.7862 0.9542 1554904 Bionet1_002348 CCOC(=O)c1cc(C#N)c(Oc2ccc(F)cc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B11 compound treatment 0.357 0.00528 0.27 0.359 -6.77E-4 -0.04 0.162 0.5933 1909381 Bionet1_002349 CS(=O)(=O)c1ccccc1c2nc(no2)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B12 compound treatment 0.364 0.0123 0.63 0.363 0.00332 0.2 0.5859 0.8887 1909382 Bionet1_002350 CCOC(=O)c1cc(C#N)c(Oc2ccccc2OC)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B13 compound treatment 0.353 0.00128 0.07 0.362 0.00232 0.14 0.1455 0.94 1909383 Bionet1_002351 COc1ccc(cc1)C(=O)O/N=C/2\C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B14 compound treatment 0.353 0.00128 0.07 0.357 -0.00268 -0.16 -0.068 -0.3897 1651941 Bionet1_002352 CCOC(=O)c1cc(C#N)c(Oc2ccc(Cl)cc2C)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B15 compound treatment 0.358 0.00628 0.32 0.362 0.00232 0.14 0.3262 0.931 1909384 Bionet1_002353 Cc1ccc(cc1)C(=O)O/N=C/2\C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B16 compound treatment 0.36 0.00828 0.42 0.363 0.00332 0.2 0.4412 0.9417 1227034 Bionet1_002354 O=S(=O)(Cc1cc(nc(n1)c2ccncc2)N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B17 compound treatment 0.353 0.00128 0.07 0.369 0.00932 0.56 0.4443 0.7841 1909385 Bionet1_002355 Clc1ccc(cc1)C(=O)O/N=C/2\C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B18 compound treatment 0.358 0.00628 0.32 0.365 0.00532 0.32 0.4543 1.0 1458986 Bionet1_002356 O=S(Cc1cc(nc(n1)c2ccccc2)N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B19 compound treatment 0.35 -0.00172 -0.09 0.356 -0.00368 -0.22 -0.2191 -0.9177 1909386 Bionet1_002357 Clc1ccccc1C(=O)O/N=C/2\C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B20 compound treatment 0.364 0.0123 0.63 0.366 0.00632 0.38 0.7139 0.9715 1718922 Bionet1_002358 CCOC(=O)c1cc(C#N)c(NCc2ccccc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B21 compound treatment 0.364 0.0123 0.63 0.361 0.00132 0.08 0.5005 0.7906 1909387 Bionet1_002359 Cc1ccccc1C(=O)O/N=C/2\C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B22 compound treatment 0.356 0.00428 0.22 0.36 3.23E-4 0.02 0.1686 0.767 1175752 Bionet1_002360 CCOC(=O)c1cc(C#N)c(nc1c2ccccc2)N(C)Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B23 positive control 0.087 -0.265 -13.54 0.091 -0.269 -16.22 -21.0402 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 B24 positive control 0.087 -0.265 -13.54 0.091 -0.269 -16.22 -21.0402 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C01 mock treatment 0.354 0.00228 0.12 0.349 -0.0107 -0.64 -0.3733 -0.5699 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C02 mock treatment 0.365 0.0133 0.68 0.363 0.00332 0.2 0.622 0.8784 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C03 compound treatment 0.37 0.0183 0.93 0.383 0.0233 1.41 1.6565 0.9802 1909388 Bionet1_002361 [O-][N+](=O)CCc1ccccc1NC(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C04 compound treatment 0.385 0.0333 1.7 0.403 0.0433 2.62 3.0526 0.9783 1909389 Bionet1_002362 FC(F)(F)c1cccc(Sc2nnc(cc2C#N)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C05 compound treatment 0.361 0.00928 0.47 0.373 0.0133 0.8 0.9043 0.9683 1909390 Bionet1_002363 CCOc1ccccc1N2CCN(CC2)c3cc(Cl)nc(SC)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C06 compound treatment 0.352 2.81E-4 0.01 0.369 0.00932 0.56 0.4081 0.7249 1909391 Bionet1_002364 Cc1ccc(cc1)c2nc(C)ncc2N=Nc3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C07 compound treatment 0.355 0.00328 0.17 0.36 3.23E-4 0.02 0.1324 0.7839 1909392 Bionet1_002365 CSc1nc(Cl)cc(n1)N2CCN(CC2)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C08 compound treatment 0.353 0.00128 0.07 0.366 0.00632 0.38 0.3162 0.8165 1909393 Bionet1_002366 COc1ccc(N=Nc2cnc(nc2c3ccc(OC)cc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C09 compound treatment 0.36 0.00828 0.42 0.367 0.00732 0.44 0.612 0.9998 1413630 Bionet1_002367 Cc1cc(nc(SCc2ccc(Cl)cc2Cl)n1)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C10 compound treatment 0.354 0.00228 0.12 0.373 0.0133 0.8 0.6512 0.8013 1909394 Bionet1_002368 COc1ccc(N=Nc2cnc(nc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C11 compound treatment 0.352 2.81E-4 0.01 0.36 3.23E-4 0.02 0.0239 0.9889 1909395 Bionet1_002369 Clc1ccc(CSCc2cc(Cl)nc(n2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C12 compound treatment 0.352 2.81E-4 0.01 0.361 0.00132 0.08 0.0666 0.8213 1909396 Bionet1_002370 COc1ccc(N=Nc2cnc(nc2c3ccccc3)c4ccncc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C13 compound treatment 0.348 -0.00372 -0.19 0.354 -0.00568 -0.34 -0.3768 -0.9614 1909397 Bionet1_002371 Cc1nc(CSc2ccc(Cl)cc2)cc(OCc3cccc(Cl)c3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C14 compound treatment 0.346 -0.00572 -0.29 0.351 -0.00868 -0.52 -0.5772 -0.9621 1909398 Bionet1_002372 Cc1cccc(N=Nc2cnc(nc2c3cccs3)c4ccncc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C15 compound treatment 0.361 0.00928 0.47 0.358 -0.00168 -0.1 0.264 0.544 1909399 Bionet1_002373 Cc1nc(CS(=O)(=O)c2ccccc2)cc(Sc3ccc(Cl)cc3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C16 compound treatment 0.35 -0.00172 -0.09 0.363 0.00332 0.2 0.0797 0.3639 1909400 Bionet1_002374 Cc1cccc(N=Nc2cnc(nc2c3cccs3)c4ccccn4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C17 compound treatment 0.362 0.0103 0.53 0.368 0.00832 0.5 0.727 0.9997 1909401 Bionet1_002375 Cc1ccc(Sc2cc(CS(=O)(=O)c3ccccc3)nc(C)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C18 compound treatment 0.351 -7.19E-4 -0.04 0.361 0.00132 0.08 0.0305 0.3467 1909402 Bionet1_002376 Clc1ccc(N=Nc2cnc(nc2c3cccs3)c4cccnc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C19 compound treatment 0.356 0.00428 0.22 0.353 -0.00668 -0.4 -0.1302 -0.2839 1909403 Bionet1_002377 Cc1nc(CS(=O)(=O)c2ccccc2)cc(Sc3ccccc3Cl)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C20 compound treatment 0.354 0.00228 0.12 0.366 0.00632 0.38 0.3524 0.8829 1552166 Bionet1_002378 CCOC(=O)c1cc(nnc1Sc2ccc(F)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C21 compound treatment 0.367 0.0153 0.78 0.358 -0.00168 -0.1 0.4809 0.6104 1909404 Bionet1_002379 COc1ccc(Sc2cc(CS(=O)(=O)c3ccccc3)nc(C)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C22 compound treatment 0.356 0.00428 0.22 0.364 0.00432 0.26 0.3393 0.9962 1909405 Bionet1_002380 COc1ccc(cc1)c2nc(ncc2N=Nc3ccc(F)cc3)c4ccncc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C23 positive control 0.084 -0.268 -13.69 0.086 -0.274 -16.52 -21.3621 -0.9956 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 C24 positive control 0.089 -0.263 -13.43 0.095 -0.265 -15.98 -20.7971 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D01 mock treatment 0.343 -0.00872 -0.45 0.352 -0.00768 -0.46 -0.643 -0.9998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D02 mock treatment 0.352 2.81E-4 0.01 0.355 -0.00468 -0.28 -0.1895 -0.6702 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D03 compound treatment 0.364 0.0123 0.63 0.384 0.0243 1.47 1.4823 0.9282 1909406 Bionet1_002381 Clc1ccc(CO/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D04 compound treatment 0.353 0.00128 0.07 0.364 0.00432 0.26 0.2308 0.858 1591763 Bionet1_002382 CCOC(=O)c1cc(C#N)c(NCc2ccc(Cl)cc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D05 compound treatment 0.351 -7.19E-4 -0.04 0.349 -0.0107 -0.64 -0.4818 -0.7462 1909407 Bionet1_002383 Fc1cccc(Cl)c1CO/N=C/2\C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D06 compound treatment 0.366 0.0143 0.73 0.376 0.0163 0.99 1.2131 0.9891 1232522 Bionet1_002384 CCOC(=O)c1cc(C#N)c(NCc2ccccc2OC)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D07 compound treatment 0.35 -0.00172 -0.09 0.369 0.00932 0.56 0.3358 0.5895 1909408 Bionet1_002385 CC(C)(C)c1ccc(CO/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D08 compound treatment 0.398 0.0463 2.37 0.416 0.0563 3.4 4.0776 0.9843 1313129 Bionet1_002386 CCOC(=O)c1cc(C#N)c(NCc2cccc(Cl)c2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D09 compound treatment 0.359 0.00728 0.37 0.372 0.0123 0.74 0.7893 0.9488 1909409 Bionet1_002387 FC(F)(F)c1cccc(CO/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D10 compound treatment 0.367 0.0153 0.78 0.359 -6.77E-4 -0.04 0.5236 0.6692 1456466 Bionet1_002388 CCOC(=O)c1cc(C#N)c(NCc2ccc(C)cc2)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D11 compound treatment 0.341 -0.0107 -0.55 0.352 -0.00768 -0.46 -0.7153 -0.9965 1909410 Bionet1_002389 Clc1cccc(Cl)c1CO/N=C\2/C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D12 compound treatment 0.363 0.0113 0.58 0.368 0.00832 0.5 0.7632 0.9976 1909411 Bionet1_002390 FC(F)(F)c1cc(Nc2nnnc3ccccc23)cc(c1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D13 compound treatment 0.346 -0.00572 -0.29 0.356 -0.00368 -0.22 -0.3637 -0.9908 1909412 Bionet1_002391 On1c(nc2ccc(Br)cc2c1=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D14 compound treatment 0.369 0.0173 0.88 0.375 0.0153 0.92 1.2789 0.9997 1909413 Bionet1_002392 O=S(Cc1cc(Oc2ccccc2)nc(n1)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D15 compound treatment 0.348 -0.00372 -0.19 0.352 -0.00768 -0.46 -0.4622 -0.9226 1240287 Bionet1_002393 On1c(nc2ccc(Br)cc2c1=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D16 compound treatment 0.346 -0.00572 -0.29 0.352 -0.00768 -0.46 -0.5345 -0.9753 1909414 Bionet1_002394 [O-][N+](=O)c1ccc(Oc2nc(nc3ccccc23)C(F)(F)F)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D17 compound treatment 0.352 2.81E-4 0.01 0.349 -0.0107 -0.64 -0.4456 -0.6912 1734265 Bionet1_002395 On1c(nc2ccc(Br)cc2c1=O)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D18 compound treatment 0.348 -0.00372 -0.19 0.35 -0.00968 -0.58 -0.5476 -0.8912 1909415 Bionet1_002396 FC(F)(F)c1nc(N/N=C/c2ccc(Cl)cc2)c3ccccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D19 compound treatment 0.352 2.81E-4 0.01 0.356 -0.00368 -0.22 -0.1468 -0.6599 1312519 Bionet1_002397 On1c(nc2ccc(Br)cc2c1=O)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D20 compound treatment 0.358 0.00628 0.32 0.365 0.00532 0.32 0.4543 1.0 1909416 Bionet1_002398 [O-][N+](=O)c1cccc(/C=N/Nc2nc(nc3ccccc23)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D21 compound treatment 0.353 0.00128 0.07 0.378 0.0183 1.11 0.8285 0.7477 1719573 Bionet1_002399 On1c(nc2ccc(Br)cc2c1=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D22 compound treatment 0.353 0.00128 0.07 0.357 -0.00268 -0.16 -0.068 -0.3897 1909417 Bionet1_002400 [O-][N+](=O)c1cccc(c1)c2nnc3c4ccccc4nc(n23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D23 positive control 0.085 -0.267 -13.64 0.089 -0.271 -16.34 -21.1979 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 D24 positive control 0.089 -0.263 -13.43 0.092 -0.268 -16.16 -20.9252 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E01 mock treatment 0.351 -7.19E-4 -0.04 0.353 -0.00668 -0.4 -0.311 -0.7684 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E02 mock treatment 0.361 0.00928 0.47 0.367 0.00732 0.44 0.6482 0.9994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E03 compound treatment 0.359 0.00728 0.37 0.368 0.00832 0.5 0.6185 0.9891 1183316 Bionet1_002401 Cc1nc(CS(=O)(=O)c2ccc(Cl)cc2)cc(n1)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E04 compound treatment 0.361 0.00928 0.47 0.368 0.00832 0.5 0.6908 0.9996 1909418 Bionet1_002402 Cc1ccc(cc1)c2nc(N)ncc2N=Nc3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E05 compound treatment 0.36 0.00828 0.42 0.377 0.0173 1.05 1.0389 0.9208 1909419 Bionet1_002403 COc1cc(c(Cl)cc1Cl)n2nnnc2c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E06 compound treatment 0.371 0.0193 0.99 0.383 0.0233 1.41 1.6927 0.9848 1909420 Bionet1_002404 Cc1nn(nc1C(=O)Nc2ccc(Br)cc2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E07 compound treatment 0.338 -0.0137 -0.7 0.356 -0.00368 -0.22 -0.653 -0.8875 1909421 Bionet1_002405 COc1cc(NC(=O)c2cccc(c2)C(F)(F)F)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E08 compound treatment 0.377 0.0253 1.29 0.369 0.00932 0.56 1.312 0.9306 1658815 Bionet1_002406 Cc1snc2sc(C(=O)c3ccc(Br)cc3)c(N)c12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E09 compound treatment 0.359 0.00728 0.37 0.388 0.0283 1.71 1.4723 0.8414 1727351 Bionet1_002407 CC(C)Oc1cc(NC(=O)c2ccc(Cl)c(Cl)c2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E10 compound treatment 0.357 0.00528 0.27 0.351 -0.00868 -0.52 -0.1795 -0.3045 1250104 Bionet1_002408 Cc1cc(C)n(Cc2ccccc2)c(=O)c1S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E11 compound treatment 0.341 -0.0107 -0.55 0.354 -0.00568 -0.34 -0.6299 -0.9744 1909422 Bionet1_002409 COc1cc(c(Cl)cc1Cl)n2nnnc2c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E12 compound treatment 0.346 -0.00572 -0.29 0.355 -0.00468 -0.28 -0.4064 -0.9998 1649533 Bionet1_002410 Cc1cc(C)n(Cc2ccc(Cl)cc2)c(=O)c1S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E13 compound treatment 0.351 -7.19E-4 -0.04 0.36 3.23E-4 0.02 -0.0122 -0.2937 1909423 Bionet1_002411 COc1cc(c(Cl)cc1Cl)n2nnnc2c3c(F)cccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E14 compound treatment 0.354 0.00228 0.12 0.362 0.00232 0.14 0.1816 0.9958 1163023 Bionet1_002412 Cc1cc(C)c(c(SCc2ccccc2)n1)S(=O)(=O)c3ccccc3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E15 compound treatment 0.359 0.00728 0.37 0.362 0.00232 0.14 0.3624 0.9109 1909424 Bionet1_002413 COCCOc1cc(NC(=O)c2ccccc2Cl)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E16 compound treatment 0.34 -0.0117 -0.6 0.354 -0.00568 -0.34 -0.6661 -0.9649 1909425 Bionet1_002414 CCCCSc1nc(C)cc(C)c1S(=O)(=O)c2ccccc2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E17 compound treatment 0.363 0.0113 0.58 0.361 0.00132 0.08 0.4643 0.7974 1909426 Bionet1_002415 COCCOc1cc(NC(=O)c2cccc(OC)c2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E18 compound treatment 0.357 0.00528 0.27 0.358 -0.00168 -0.1 0.1193 0.4138 1562043 Bionet1_002416 Cc1cc([nH]c(=O)c1S(=O)(=O)c2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E19 compound treatment 0.353 0.00128 0.07 0.356 -0.00368 -0.22 -0.1107 -0.4781 1133687 Bionet1_002417 CCOC(=O)COc1cc(NC(=O)c2ccc(OC)cc2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E20 compound treatment 0.354 0.00228 0.12 0.356 -0.00368 -0.22 -0.0745 -0.2971 1280487 Bionet1_002418 CC(C)CSc1nc(C)cc(C)c1S(=O)(=O)c2ccccc2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E21 compound treatment 0.362 0.0103 0.53 0.391 0.0313 1.89 1.7088 0.8707 1909427 Bionet1_002419 CC(C)Oc1cc(c(Cl)cc1Cl)n2nnnc2c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E22 compound treatment 0.354 0.00228 0.12 0.364 0.00432 0.26 0.267 0.9341 1145208 Bionet1_002420 Cc1cc(C)c(c(Oc2ccccc2)n1)S(=O)(=O)c3ccccc3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E23 positive control 0.087 -0.265 -13.54 0.086 -0.274 -16.52 -21.2536 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 E24 positive control 0.092 -0.26 -13.28 0.099 -0.261 -15.74 -20.5179 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F01 mock treatment 0.349 -0.00272 -0.14 0.359 -6.77E-4 -0.04 -0.1272 -0.8779 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F02 mock treatment 0.359 0.00728 0.37 0.365 0.00532 0.32 0.4905 0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F03 compound treatment 0.365 0.0133 0.68 0.366 0.00632 0.38 0.7501 0.9629 1710801 Bionet1_002421 CCOC(=O)COc1cc(N2C(=O)CSCC2=O)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F04 compound treatment 0.365 0.0133 0.68 0.37 0.0103 0.62 0.9208 0.9991 1909428 Bionet1_002422 COc1ccc(cc1)C(=O)NN(C)c2nc(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F05 compound treatment 0.367 0.0153 0.78 0.392 0.0323 1.95 1.9323 0.9193 1335341 Bionet1_002423 Clc1cc(Cl)c(cc1OCc2ccccc2)N3C(=O)CSCC3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F06 compound treatment 0.365 0.0133 0.68 0.378 0.0183 1.11 1.2623 0.9726 1909429 Bionet1_002424 FC(F)(F)c1nc(NNC(=O)c2ccc(Cl)cc2)c3ccccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F07 compound treatment 0.353 0.00128 0.07 0.37 0.0103 0.62 0.487 0.7772 1909430 Bionet1_002425 COCCOc1cc(N2C(=O)CSCC2=O)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F08 compound treatment 0.367 0.0153 0.78 0.369 0.00932 0.56 0.9505 0.987 1909431 Bionet1_002426 CN(NC(=O)c1ccccc1F)c2nc(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F09 compound treatment 0.369 0.0173 0.88 0.383 0.0233 1.41 1.6204 0.9748 1909432 Bionet1_002427 Clc1ccc(CO/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F10 compound treatment 0.331 -0.0207 -1.06 0.365 0.00532 0.32 -0.5219 -0.4714 1460281 Bionet1_002428 O=S(=O)(N1CCN(CC1)c2ccccn2)c3ccc(s3)c4csnn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F11 compound treatment 0.374 0.0223 1.14 0.384 0.0243 1.47 1.8439 0.9921 1909433 Bionet1_002429 COc1ccc(CO/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F12 compound treatment 0.346 -0.00572 -0.29 0.37 0.0103 0.62 0.2339 0.3398 1909434 Bionet1_002430 COc1ccc(OS(=O)(=O)c2ccc(s2)c3csnn3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F13 compound treatment 0.373 0.0213 1.09 0.394 0.0343 2.07 2.2346 0.9548 1909435 Bionet1_002431 Clc1cccc(CO/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F14 compound treatment 0.358 0.00628 0.32 0.379 0.0193 1.17 1.0519 0.8694 1909436 Bionet1_002432 CC(C)(C)c1ccc(OS(=O)(=O)c2ccc(s2)c3csnn3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F15 compound treatment 0.369 0.0173 0.88 0.373 0.0133 0.8 1.1935 0.9989 1909437 Bionet1_002433 COc1ccnc(Oc2ccc(F)cc2)c1C(=O)N/C=N/OCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F16 compound treatment 0.355 0.00328 0.17 0.362 0.00232 0.14 0.2178 0.996 1909438 Bionet1_002434 Clc1ccc(OS(=O)(=O)c2ccc(s2)c3csnn3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F17 compound treatment 0.349 -0.00272 -0.14 0.364 0.00432 0.26 0.0862 0.2916 1166185 Bionet1_002435 COc1ccnc(Nc2ccc(I)cc2)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F18 compound treatment 0.353 0.00128 0.07 0.367 0.00732 0.44 0.3589 0.8031 1909439 Bionet1_002436 Cc1cc(C)cc(OS(=O)(=O)c2ccc(s2)c3csnn3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F19 compound treatment 0.349 -0.00272 -0.14 0.376 0.0163 0.99 0.5985 0.6014 1737568 Bionet1_002437 COc1ccnc(N2CCN(CC2)C(c3ccccc3)c4ccccc4)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F20 compound treatment 0.356 0.00428 0.22 0.365 0.00532 0.32 0.382 0.9825 1909440 Bionet1_002438 CC(=O)Nc1cccc(OS(=O)(=O)c2ccc(s2)c3csnn3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F21 compound treatment 0.363 0.0113 0.58 0.368 0.00832 0.5 0.7632 0.9976 1909441 Bionet1_002439 COc1ccnc(N/C=N/OCc2cccc(c2)C(F)(F)F)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F22 compound treatment 0.372 0.0203 1.04 0.367 0.00732 0.44 1.0459 0.9278 1909442 Bionet1_002440 NC(=O)C(c1ccc(Cl)cc1)c2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F23 positive control 0.088 -0.264 -13.48 0.09 -0.27 -16.28 -21.0467 -0.9956 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 F24 positive control 0.09 -0.262 -13.38 0.096 -0.264 -15.92 -20.7183 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G01 mock treatment 0.339 -0.0127 -0.65 0.355 -0.00468 -0.28 -0.6595 -0.9302 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G02 mock treatment 0.352 2.81E-4 0.01 0.358 -0.00168 -0.1 -0.0614 -0.6007 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G03 compound treatment 0.358 0.00628 0.32 0.362 0.00232 0.14 0.3262 0.931 1909443 Bionet1_002441 COCCOc1cc(c(Cl)cc1Cl)n2nnnc2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G04 compound treatment 0.354 0.00228 0.12 0.386 0.0263 1.59 1.2061 0.757 1433540 Bionet1_002442 Cc1cc(C)c(c(NCc2ccccc2)n1)S(=O)(=O)c3ccccc3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G05 compound treatment 0.357 0.00528 0.27 0.365 0.00532 0.32 0.4182 0.9963 1909444 Bionet1_002443 COCCOc1cc(c(Cl)cc1Cl)n2nnnc2c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G06 compound treatment 0.353 0.00128 0.07 0.369 0.00932 0.56 0.4443 0.7841 1274557 Bionet1_002444 Cc1ccccc1S(=O)(=O)c2c(C)c(c(C)nc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G07 compound treatment 0.359 0.00728 0.37 0.369 0.00932 0.56 0.6612 0.9799 1909445 Bionet1_002445 COCCOc1cc(c(Cl)cc1Cl)n2nnnc2c3cccc(OC)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G08 compound treatment 0.353 0.00128 0.07 0.373 0.0133 0.8 0.615 0.7622 1332850 Bionet1_002446 Cc1cc(C)c(c(OCCN2CCOCC2)n1)S(=O)(=O)c3ccccc3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G09 compound treatment 0.345 -0.00672 -0.34 0.363 0.00332 0.2 -0.1011 -0.2541 1171195 Bionet1_002447 COc1cc(c(Cl)cc1Cl)n2c(S)nc3ccccc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G10 compound treatment 0.373 0.0213 1.09 0.392 0.0323 1.95 2.1492 0.962 1909446 Bionet1_002448 COc1cccc(c1)C(=O)O/N=C/c2ccc(Sc3ccc(C)cc3)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G11 compound treatment 0.358 0.00628 0.32 0.401 0.0413 2.49 1.991 0.7916 1169258 Bionet1_002449 COc1cc(c(Cl)cc1Cl)n2c(SC)nc3ccccc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G12 compound treatment 0.362 0.0103 0.53 0.398 0.0383 2.31 2.0076 0.8462 1909447 Bionet1_002450 Cc1ccc(Oc2ccc(/C=N/OCc3ccc(Cl)cc3Cl)cn2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G13 compound treatment 0.375 0.0233 1.19 0.394 0.0343 2.07 2.3069 0.9654 1514662 Bionet1_002451 COc1cc(c(Cl)cc1Cl)n2c(SCC=C)nc3ccccc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G14 compound treatment 0.35 -0.00172 -0.09 0.367 0.00732 0.44 0.2504 0.5557 1909448 Bionet1_002452 Fc1ccc(CO/N=C/c2ccc(Sc3ccc(Cl)cc3)nc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G15 compound treatment 0.367 0.0153 0.78 0.409 0.0493 2.98 2.6579 0.8634 1909449 Bionet1_002453 COc1cc(NS(=O)(=O)c2ccc(Cl)cc2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G16 compound treatment 0.346 -0.00572 -0.29 0.363 0.00332 0.2 -0.0649 -0.1831 1909450 Bionet1_002454 COc1ccc(cc1)C(=O)O/N=C/c2ccc(Sc3ccc(Cl)cc3)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G17 compound treatment 0.352 2.81E-4 0.01 0.392 0.0323 1.95 1.3899 0.7123 1909451 Bionet1_002455 COc1cc(NS(=O)(=O)c2ccc(F)cc2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G18 compound treatment 0.357 0.00528 0.27 0.377 0.0173 1.05 0.9304 0.8614 1909452 Bionet1_002456 Cc1ccc(Sc2ccc(/C=N/OC(=O)c3ccccc3Cl)cn2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G19 compound treatment 0.339 -0.0127 -0.65 0.379 0.0193 1.17 0.365 0.2733 1215028 Bionet1_002457 CC(C)Oc1cc(NS(=O)(=O)c2ccc(Cl)cc2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G20 compound treatment 0.359 0.00728 0.37 0.363 0.00332 0.2 0.4051 0.9579 1909453 Bionet1_002458 CC(C)CC(=O)O/N=C/c1ccc(nc1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G21 compound treatment 0.355 0.00328 0.17 0.378 0.0183 1.11 0.9008 0.8052 1909454 Bionet1_002459 Clc1ccc(CSCc2cc(nc(n2)c3ccccc3)N4CCCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G22 compound treatment 0.353 0.00128 0.07 0.379 0.0193 1.17 0.8711 0.7456 1909455 Bionet1_002460 CSc1ccccc1c2nnc(SCc3ccc(Cl)cc3Cl)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G23 positive control 0.088 -0.264 -13.48 0.089 -0.271 -16.34 -21.0894 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 G24 positive control 0.093 -0.259 -13.23 0.095 -0.265 -15.98 -20.6525 -0.9956 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H01 mock treatment 0.351 -7.19E-4 -0.04 0.376 0.0163 0.99 0.6708 0.6803 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H02 mock treatment 0.366 0.0143 0.73 0.365 0.00532 0.32 0.7436 0.932 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H03 compound treatment 0.34 -0.0117 -0.6 0.367 0.00732 0.44 -0.1111 -0.1492 1909456 Bionet1_002461 COc1ccnc(N/C=N/OCCOc2cccc(c2)C(F)(F)F)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H04 compound treatment 0.355 0.00328 0.17 0.372 0.0123 0.74 0.6446 0.8454 1909457 Bionet1_002462 CCn1ncc(NCCNc2ncc(cc2Cl)C(F)(F)F)c(Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H05 compound treatment 0.352 2.81E-4 0.01 0.38 0.0203 1.23 0.8777 0.7153 1469928 Bionet1_002463 COc1ccnc(Oc2ccc(cc2)S(=O)(=O)N3CCOCC3)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H06 compound treatment 0.35 -0.00172 -0.09 0.365 0.00532 0.32 0.1651 0.4955 1183788 Bionet1_002464 COc1ccc(cc1)n2ncc(ON3C(=O)CCC3=O)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H07 compound treatment 0.374 0.0223 1.14 0.399 0.0393 2.37 2.4842 0.9434 1909458 Bionet1_002465 COc1ccnc(N/C=N/OCc2cccc(Cl)c2Cl)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H08 compound treatment 0.351 -7.19E-4 -0.04 0.392 0.0323 1.95 1.3538 0.6937 1543954 Bionet1_002466 COc1ccc(cc1)n2ncc(N(C)CCOC(=O)C3CC3)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H09 compound treatment 0.366 0.0143 0.73 0.402 0.0423 2.55 2.323 0.8742 1909459 Bionet1_002467 COc1ccnc(N2CCN(CC2)c3cccc(c3)C(F)(F)F)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H10 compound treatment 0.361 0.00928 0.47 0.397 0.0373 2.25 1.9288 0.8377 1601814 Bionet1_002468 COc1ccc(cc1)n2ncc(NCCc3ccccn3)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H11 compound treatment 0.341 -0.0107 -0.55 0.379 0.0193 1.17 0.4373 0.3393 1330160 Bionet1_002469 COc1ccnc(Oc2ccc(cc2)S(=O)(=O)NC(C)(C)C)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H12 compound treatment 0.356 0.00428 0.22 0.372 0.0123 0.74 0.6808 0.878 1909460 Bionet1_002470 CN(CCO)c1cnn(c2ncc(cc2Cl)C(F)(F)F)c(=O)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H13 compound treatment 0.368 0.0163 0.83 0.383 0.0233 1.41 1.5842 0.9686 1909461 Bionet1_002471 COc1ccnc(c1C#N)n2cccc2/C=N/OCc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H14 compound treatment 0.385 0.0333 1.7 0.419 0.0593 3.58 3.7356 0.9422 1909462 Bionet1_002472 FC(F)(F)c1cnc(c(Cl)c1)n2ncc(N3CCNCC3)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H15 compound treatment 0.355 0.00328 0.17 0.385 0.0253 1.53 1.1996 0.78 1909463 Bionet1_002473 COc1cccc(CO/N=C/c2cccn2c3nccc(OC)c3C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H16 compound treatment 0.382 0.0303 1.55 0.394 0.0343 2.07 2.56 0.9897 1909464 Bionet1_002474 FC(F)(F)c1cnc(c(Cl)c1)n2nccc2c3sccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H17 compound treatment 0.362 0.0103 0.53 0.387 0.0273 1.65 1.538 0.8884 1909465 Bionet1_002475 COc1ccnc(c1C#N)n2cccc2/C=N/OCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H18 compound treatment 0.36 0.00828 0.42 0.409 0.0493 2.98 2.4048 0.7996 1401731 Bionet1_002476 Clc1ccc(c(Cl)c1)n2ncc(N3CCC(=O)CC3)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H19 compound treatment 0.361 0.00928 0.47 0.385 0.0253 1.53 1.4165 0.885 1909466 Bionet1_002477 COc1ccnc(c1C#N)n2cccc2/C=N/OCc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H20 compound treatment 0.361 0.00928 0.47 0.386 0.0263 1.59 1.4592 0.8799 1238514 Bionet1_002478 COc1ccc(cc1)n2ncc(N3CCC(CC3)C(=O)N)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H21 compound treatment 0.365 0.0133 0.68 0.388 0.0283 1.71 1.6892 0.9182 1909467 Bionet1_002479 CO/N=C/NC(=O)c1c(OC)ccnc1Oc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H22 compound treatment 0.378 0.0263 1.34 0.391 0.0313 1.89 2.2873 0.986 1909468 Bionet1_002480 FC(F)(F)c1cnc(c(Cl)c1)n2ncc(N3CCOCC3)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H23 positive control 0.087 -0.265 -13.54 0.092 -0.268 -16.16 -20.9975 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 H24 positive control 0.093 -0.259 -13.23 0.097 -0.263 -15.86 -20.5671 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I01 mock treatment 0.344 -0.00772 -0.39 0.353 -0.00668 -0.4 -0.5641 -0.9999 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I02 mock treatment 0.359 0.00728 0.37 0.362 0.00232 0.14 0.3624 0.9109 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I03 compound treatment 0.358 0.00628 0.32 0.371 0.0113 0.68 0.7104 0.9407 1909469 Bionet1_002481 CN(C)c1cc(CSCc2ccc(Cl)cc2)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I04 compound treatment 0.348 -0.00372 -0.19 0.355 -0.00468 -0.28 -0.3341 -0.9815 1471760 Bionet1_002482 CS(=O)c1ccccc1COC(=O)Nc2cc(Cl)cc(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I05 compound treatment 0.368 0.0163 0.83 0.369 0.00932 0.56 0.9866 0.9818 1296388 Bionet1_002483 Sc1nccn1c2cc(OCc3ccccc3)c(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I06 compound treatment 0.349 -0.00272 -0.14 0.357 -0.00268 -0.16 -0.2126 -0.9972 1909470 Bionet1_002484 CS(=O)(=O)c1ccccc1COC(=O)Nc2cc(Cl)cc(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I07 compound treatment 0.337 -0.0147 -0.75 0.353 -0.00668 -0.4 -0.8172 -0.9572 1490195 Bionet1_002485 COc1cc(c(Cl)cc1Cl)n2ccnc2SCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I08 compound treatment 0.375 0.0233 1.19 0.39 0.0303 1.83 2.1361 0.9783 1909471 Bionet1_002486 CSc1ccccc1c2nnc(SCc3ccc(Cl)c(Cl)c3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I09 compound treatment 0.334 -0.0177 -0.91 0.374 0.0143 0.86 -0.0293 -0.0234 1705425 Bionet1_002487 CSc1nccn1c2cc(OCc3ccccc3)c(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I10 compound treatment 0.378 0.0263 1.34 0.382 0.0223 1.35 1.9031 1.0 1909472 Bionet1_002488 CSc1ccccc1c2nnc(SCc3ccc(cc3)C(C)(C)C)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I11 compound treatment 0.343 -0.00872 -0.45 0.36 3.23E-4 0.02 -0.3015 -0.6756 1909473 Bionet1_002489 COCCOc1cc(NS(=O)(=O)c2ccccc2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I12 compound treatment 0.337 -0.0147 -0.75 0.362 0.00232 0.14 -0.433 -0.5656 1909474 Bionet1_002490 FC(F)(F)c1cccc(NC(=O)NNC(=O)C2Cc3cncn3C(=O)N2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I13 compound treatment 0.351 -7.19E-4 -0.04 0.365 0.00532 0.32 0.2012 0.6222 1209136 Bionet1_002491 CS(=O)(=O)Cc1cc(NCc2ccccc2)nc(n1)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I14 compound treatment 0.434 0.0823 4.21 0.449 0.0893 5.39 6.7879 0.9925 1669035 Bionet1_002492 CCOC(=O)Cc1ncccc1C(=O)Nc2ccc(Oc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I15 compound treatment 0.367 0.0153 0.78 0.361 0.00132 0.08 0.609 0.7753 1909475 Bionet1_002493 CS(=O)(=O)Cc1cc(Sc2ccccc2)nc(n1)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I16 compound treatment 0.412 0.0603 3.08 0.41 0.0503 3.04 4.3276 1.0 1909476 Bionet1_002494 CCOC(=O)Cc1ncccc1C(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I17 compound treatment 0.365 0.0133 0.68 0.36 3.23E-4 0.02 0.494 0.7271 1909477 Bionet1_002495 CSCc1cc(Sc2ccc(Cl)cc2)nc(n1)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I18 compound treatment 0.423 0.0713 3.64 0.43 0.0703 4.25 5.5791 0.9971 1909478 Bionet1_002496 CCOC(=O)Cc1ncccc1C(=O)Nc2ccc(OC(F)(F)F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I19 compound treatment 0.357 0.00528 0.27 0.357 -0.00268 -0.16 0.0767 0.2436 1909479 Bionet1_002497 COc1cc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I20 compound treatment 0.381 0.0293 1.5 0.387 0.0273 1.65 2.225 0.9988 1722980 Bionet1_002498 COc1ccc(NC(=O)CC(=O)Nc2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I21 compound treatment 0.359 0.00728 0.37 0.37 0.0103 0.62 0.7039 0.9697 1909480 Bionet1_002499 CN(NC(=O)Nc1ccc(Cl)cc1)c2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I22 compound treatment 0.363 0.0113 0.58 0.37 0.0103 0.62 0.8485 0.9993 1466830 Bionet1_002500 Clc1ccc(NC(=O)CC(=O)Nc2ccc(Cl)c(Cl)c2)nc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I23 positive control 0.09 -0.262 -13.38 0.089 -0.271 -16.34 -21.0171 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 I24 positive control 0.094 -0.258 -13.18 0.097 -0.263 -15.86 -20.531 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J01 mock treatment 0.346 -0.00572 -0.29 0.356 -0.00368 -0.22 -0.3637 -0.9908 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J02 mock treatment 0.358 0.00628 0.32 0.369 0.00932 0.56 0.6251 0.9646 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J03 compound treatment 0.359 0.00728 0.37 0.365 0.00532 0.32 0.4905 0.9973 1909481 Bionet1_002501 COc1ccnc(Oc2ccccc2)c1C(=O)N/C=N/OCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J04 compound treatment 0.357 0.00528 0.27 0.362 0.00232 0.14 0.2901 0.9534 1909482 Bionet1_002502 CN1C(=O)N(C)C(=O)C(=Cc2c(C)nn(c2OCC=C)c3ccccc3)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J05 compound treatment 0.363 0.0113 0.58 0.375 0.0153 0.92 1.062 0.9742 1909483 Bionet1_002503 COc1ccnc(Oc2ccccc2)c1C(=O)N/C=N/OCc3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J06 compound treatment 0.36 0.00828 0.42 0.367 0.00732 0.44 0.612 0.9998 1327076 Bionet1_002504 COc1ccc(cc1)N2CCN(CC2)c3cc(O)n(C4CCCCC4)c(=O)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J07 compound treatment 0.442 0.0903 4.62 0.45 0.0903 5.45 7.1198 0.9966 1909484 Bionet1_002505 COc1ccc(cc1)N2C(=O)/C(=C/c3ccc(cc3)C(C)C)/NC2=S 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J08 compound treatment 0.35 -0.00172 -0.09 0.354 -0.00568 -0.34 -0.3045 -0.8606 1653614 Bionet1_002506 Oc1cc(nc(=O)n1C2CCCCC2)N3CCN(CC3)c4cccc(Cl)n4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J09 compound treatment 0.353 0.00128 0.07 0.363 0.00332 0.2 0.1882 0.8917 1909485 Bionet1_002507 CCOC(=O)CNC(=S)NNc1ncc(cc1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J10 compound treatment 0.365 0.0133 0.68 0.368 0.00832 0.5 0.8355 0.989 1909486 Bionet1_002508 Clc1ccsc1C(=O)c2conc2c3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J11 compound treatment 0.381 0.0293 1.5 0.379 0.0193 1.17 1.8835 0.9924 1909487 Bionet1_002509 FC(F)(F)c1nc2ccccc2nc1SCC(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J12 compound treatment 0.374 0.0223 1.14 0.349 -0.0107 -0.64 0.3498 0.2672 1909488 Bionet1_002510 Clc1ccc(/C=C/C(=O)c2sccc2Br)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J13 compound treatment 0.378 0.0263 1.34 0.387 0.0273 1.65 2.1165 0.9948 1909489 Bionet1_002511 FC(F)(F)c1ccc(N/C=C(\C=C\C#N)/S(=O)(=O)c2ccccc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J14 compound treatment 0.349 -0.00272 -0.14 0.354 -0.00568 -0.34 -0.3407 -0.921 1909490 Bionet1_002512 CS(=O)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J15 compound treatment 0.375 0.0233 1.19 0.396 0.0363 2.19 2.3923 0.9588 1909491 Bionet1_002513 COC(=O)/C=C/C(=C\Nc1ccc(OC)cc1)/S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J16 compound treatment 0.358 0.00628 0.32 0.351 -0.00868 -0.52 -0.1433 -0.2332 1624052 Bionet1_002514 CSc1ccc(NC(=O)c2ccccc2C(=O)c3ccc(F)cc3)cc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J17 compound treatment 0.378 0.0263 1.34 0.388 0.0283 1.71 2.1592 0.9929 1909492 Bionet1_002515 COC(=O)c1ccccc1N/C=C/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J18 compound treatment 0.356 0.00428 0.22 0.356 -0.00368 -0.22 -0.0022 -0.007 1656894 Bionet1_002516 CS(=O)(=O)c1ccc(NC(=O)c2cc(Cl)ccc2Cl)cc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J19 compound treatment 0.357 0.00528 0.27 0.37 0.0103 0.62 0.6316 0.93 1909493 Bionet1_002517 COC(=O)/C=C/C(=C\Nc1ccc(F)cc1)/S(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J20 compound treatment 0.359 0.00728 0.37 0.36 3.23E-4 0.02 0.277 0.7431 1559389 Bionet1_002518 CS(=O)(=O)c1ccc(NC(=O)c2cc(F)c(F)cc2Cl)cc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J21 compound treatment 0.362 0.0103 0.53 0.36 3.23E-4 0.02 0.3855 0.7328 1909494 Bionet1_002519 Cc1cc(C)c(CSC(C)(C)CNC(=O)c2cccc(c2)[N+](=O)[O-])c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J22 compound treatment 0.36 0.00828 0.42 0.355 -0.00468 -0.28 0.0998 0.196 1121925 Bionet1_002520 CS(=O)c1ccc(NC(=O)c2ccc(Cl)cc2Cl)cc1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J23 positive control 0.087 -0.265 -13.54 0.088 -0.272 -16.4 -21.1682 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 J24 positive control 0.095 -0.257 -13.13 0.095 -0.265 -15.98 -20.5802 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K01 mock treatment 0.346 -0.00572 -0.29 0.357 -0.00268 -0.16 -0.3211 -0.9609 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K02 mock treatment 0.351 -7.19E-4 -0.04 0.36 3.23E-4 0.02 -0.0122 -0.2937 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K03 compound treatment 0.396 0.0443 2.26 0.407 0.0473 2.86 3.6211 0.9934 1909495 Bionet1_002521 FC(F)(F)c1nc2ccccc2nc1N/N=C/c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K04 compound treatment 0.364 0.0123 0.63 0.371 0.0113 0.68 0.9274 0.9991 1909496 Bionet1_002522 CN(/N=C/C1CC(=O)NC(=C1C#N)C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K05 compound treatment 0.346 -0.00572 -0.29 0.353 -0.00668 -0.4 -0.4918 -0.9876 1909497 Bionet1_002523 FC(F)(F)c1nc2ccccc2nc1N/N=C/c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K06 compound treatment 0.36 0.00828 0.42 0.386 0.0263 1.59 1.423 0.8653 1909498 Bionet1_002524 FC(F)(F)c1cccc(CO/N=C\2/COc3ccc4ccccc4c23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K07 compound treatment 0.349 -0.00272 -0.14 0.352 -0.00768 -0.46 -0.426 -0.8804 1909499 Bionet1_002525 FC(F)(F)c1nc2ccccc2n3c(nnc13)c4ccc(Cl)cc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K08 compound treatment 0.377 0.0253 1.29 0.386 0.0263 1.59 2.0377 0.9948 1909500 Bionet1_002526 FC(F)(F)c1cccc(OCCO/N=C\2/COc3ccc4ccccc4c23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K09 compound treatment 0.347 -0.00472 -0.24 0.352 -0.00768 -0.46 -0.4983 -0.9537 1909501 Bionet1_002527 Cc1ccc(cc1)S(=O)(=O)NNc2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K10 compound treatment 0.34 -0.0117 -0.6 0.356 -0.00368 -0.22 -0.5807 -0.9087 1279015 Bionet1_002528 Clc1ccc(cc1Cl)c2cnc3c(NC(=O)c4cccs4)cccn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K11 compound treatment 0.373 0.0213 1.09 0.39 0.0303 1.83 2.0638 0.9691 1909502 Bionet1_002529 CN(NC(=O)c1ccccc1C)c2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K12 compound treatment 0.401 0.0493 2.52 0.386 0.0263 1.59 2.9054 0.9753 1909503 Bionet1_002530 FC(F)(F)c1cccc(N/C=C/2\Oc3ccc4ccccc4c3C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K13 compound treatment 0.372 0.0203 1.04 0.379 0.0193 1.17 1.5581 0.9983 1909504 Bionet1_002531 CN(NC(=O)c1ccc(Cl)cc1)c2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K14 compound treatment 0.347 -0.00472 -0.24 0.353 -0.00668 -0.4 -0.4556 -0.9699 1909505 Bionet1_002532 COC(=O)c1ccncc1C(=O)NN(C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K15 compound treatment 0.355 0.00328 0.17 0.363 0.00332 0.2 0.2605 0.9961 1909506 Bionet1_002533 FC(F)(F)c1nc2ccccc2nc1NNC(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K16 compound treatment 0.348 -0.00372 -0.19 0.354 -0.00568 -0.34 -0.3768 -0.9614 1909507 Bionet1_002534 CC1=C(CCC(=O)N1Cc2ccccc2)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K17 compound treatment 0.351 -7.19E-4 -0.04 0.363 0.00332 0.2 0.1158 0.5681 1909508 Bionet1_002535 Cc1ccc(/C=N/Nc2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K18 compound treatment 0.352 2.81E-4 0.01 0.36 3.23E-4 0.02 0.0239 0.9889 1412030 Bionet1_002536 COc1ccc(NC(=O)C2=C(C)N(Cc3ccccc3)C(=O)CC2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K19 compound treatment 0.348 -0.00372 -0.19 0.359 -6.77E-4 -0.04 -0.1634 -0.84 1909509 Bionet1_002537 FC(F)(F)c1cc(c2ccc(N/N=C/c3ccccc3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K20 compound treatment 0.353 0.00128 0.07 0.358 -0.00168 -0.1 -0.0253 -0.2096 1448704 Bionet1_002538 CCOC(=O)C1=C(C)N(CCN2C(=C(CCC2=O)C(=O)OCC)C)C(=O)CC1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K21 compound treatment 0.37 0.0183 0.93 0.368 0.00832 0.5 1.0162 0.9576 1909510 Bionet1_002539 FC(F)(F)c1cc(c2ccc(N/N=C/c3ccco3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K22 compound treatment 0.417 0.0653 3.34 0.411 0.0513 3.1 4.5511 0.9993 1909511 Bionet1_002540 COc1ccc(cc1)C(=O)/C(=N/Nc2ccc(cc2)C(F)(F)F)/C=N/N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K23 positive control 0.089 -0.263 -13.43 0.09 -0.27 -16.28 -21.0106 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 K24 positive control 0.094 -0.258 -13.18 0.102 -0.258 -15.56 -20.3175 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L01 mock treatment 0.35 -0.00172 -0.09 0.364 0.00432 0.26 0.1224 0.4444 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L02 mock treatment 0.355 0.00328 0.17 0.359 -6.77E-4 -0.04 0.0897 0.5195 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L03 compound treatment 0.354 0.00228 0.12 0.357 -0.00268 -0.16 -0.0318 -0.1596 1909512 Bionet1_002541 Cc1cc(C)c(CSC(C)(C)CNc2ncccc2[N+](=O)[O-])c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L04 compound treatment 0.355 0.00328 0.17 0.378 0.0183 1.11 0.9008 0.8052 1909513 Bionet1_002542 Clc1ccc(SCc2cc(nc(n2)c3ccccn3)N4CCOCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L05 compound treatment 0.357 0.00528 0.27 0.369 0.00932 0.56 0.5889 0.9434 1456431 Bionet1_002543 COc1ccc(cc1)C(=O)NCC(C)(C)SCc2c(C)cc(C)cc2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L06 compound treatment 0.343 -0.00872 -0.45 0.367 0.00732 0.44 -0.0027 -0.0042 1909514 Bionet1_002544 Clc1ccc(SCc2cc(nc(n2)c3ccccn3)N4CCCCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L07 compound treatment 0.37 0.0183 0.93 0.371 0.0113 0.68 1.1443 0.9882 1575550 Bionet1_002545 Cc1cc(C)c(CSC(C)(C)CN2C(=O)Cc3ccccc3C2=O)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L08 compound treatment 0.347 -0.00472 -0.24 0.36 3.23E-4 0.02 -0.1568 -0.6479 1503571 Bionet1_002546 O=S(=O)(Cc1cc(nc(n1)c2ccccc2)N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L09 compound treatment 0.376 0.0243 1.24 0.401 0.0413 2.49 2.6418 0.9481 1909515 Bionet1_002547 FC(F)(F)c1cnc(N/N=C/c2ccc(Cl)cc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L10 compound treatment 0.357 0.00528 0.27 0.363 0.00332 0.2 0.3328 0.9893 1373707 Bionet1_002548 O=S(=O)(Cc1cc(nc(n1)c2ccccc2)N3CCCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L11 compound treatment 0.363 0.0113 0.58 0.353 -0.00668 -0.4 0.1228 0.1746 1909516 Bionet1_002549 FC(F)(F)c1cc(Cl)c2nnc(c3ccc(Cl)cc3Cl)n2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L12 compound treatment 0.357 0.00528 0.27 0.364 0.00432 0.26 0.3755 0.9999 1909517 Bionet1_002550 Clc1ccc(SCc2cc(nc(n2)c3ccccc3)N4CCOCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L13 compound treatment 0.348 -0.00372 -0.19 0.366 0.00632 0.38 0.1354 0.3176 1681168 Bionet1_002551 COc1ccc(cc1)S(=O)(=O)NCC(C)(C)SCc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L14 compound treatment 0.354 0.00228 0.12 0.352 -0.00768 -0.46 -0.2452 -0.5131 1909518 Bionet1_002552 Clc1ccc(SCc2cc(nc(n2)c3ccccc3)N4CCCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L15 compound treatment 0.347 -0.00472 -0.24 0.36 3.23E-4 0.02 -0.1568 -0.6479 1727227 Bionet1_002553 CC(C)(CNS(=O)(=O)c1ccc(F)cc1)SCc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L16 compound treatment 0.372 0.0203 1.04 0.381 0.0213 1.29 1.6435 0.9943 1909519 Bionet1_002554 FC(F)(F)c1ccc(Sc2ccc(Br)cc2)c(C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L17 compound treatment 0.423 0.0713 3.64 0.415 0.0553 3.34 4.9388 0.999 1909520 Bionet1_002555 CC(C)(CNc1ccc(cn1)[N+](=O)[O-])SCc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L18 compound treatment 0.349 -0.00272 -0.14 0.359 -6.77E-4 -0.04 -0.1272 -0.8779 1213145 Bionet1_002556 O=S(=O)(Cc1cc(nc(n1)c2cccnc2)N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L19 compound treatment 0.351 -7.19E-4 -0.04 0.349 -0.0107 -0.64 -0.4818 -0.7462 1909521 Bionet1_002557 CC(C)(CNC(=O)Nc1ccccc1)SCc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L20 compound treatment 0.381 0.0293 1.5 0.397 0.0373 2.25 2.6519 0.9803 1230193 Bionet1_002558 O=S(=O)(Cc1cc(nc(n1)c2cccnc2)N3CCCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L21 compound treatment 0.35 -0.00172 -0.09 0.348 -0.0117 -0.7 -0.5606 -0.7892 1209182 Bionet1_002559 COc1ccc(cc1)S(=O)(=O)NCC(C)(C)SCc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L22 compound treatment 0.357 0.00528 0.27 0.364 0.00432 0.26 0.3755 0.9999 1441862 Bionet1_002560 Clc1ccc(Oc2ccc(cn2)C(=O)NC3CCSC3=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L23 positive control 0.089 -0.263 -13.43 0.09 -0.27 -16.28 -21.0106 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 L24 positive control 0.094 -0.258 -13.18 0.098 -0.262 -15.8 -20.4883 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M01 mock treatment 0.347 -0.00472 -0.24 0.363 0.00332 0.2 -0.0288 -0.0917 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M02 mock treatment 0.352 2.81E-4 0.01 0.362 0.00232 0.14 0.1093 0.7756 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M03 compound treatment 0.365 0.0133 0.68 0.368 0.00832 0.5 0.8355 0.989 1909522 Bionet1_002561 FC(F)(F)c1cc(c2ccc(N/N=C/c3cccs3)nc2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M04 compound treatment 0.367 0.0153 0.78 0.373 0.0133 0.8 1.1212 0.9999 1909523 Bionet1_002562 Cc1ccc(cc1)C(=O)/C(=N/Nc2cc(Cl)cc(Cl)c2)/C=N/O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M05 compound treatment 0.346 -0.00572 -0.29 0.366 0.00632 0.38 0.0631 0.1313 1909524 Bionet1_002563 FC(F)(F)c1cc(c2ccc3nnc(c4cccs4)n3c2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M06 compound treatment 0.425 0.0733 3.75 0.447 0.0873 5.27 6.3771 0.986 1909525 Bionet1_002564 Cc1cccc(N/N=C(\C=N\N)/C(=O)c2ccc(Br)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M07 compound treatment 0.376 0.0243 1.24 0.391 0.0313 1.89 2.215 0.9792 1909526 Bionet1_002565 FC(F)(F)c1ccc(/C=N/Nc2nc3ccccc3nc2C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M08 compound treatment 0.37 0.0183 0.93 0.378 0.0183 1.11 1.4431 0.9965 1909527 Bionet1_002566 N/N=C/C(=N/Nc1ccc(Cl)cc1)/C(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M09 compound treatment 0.383 0.0313 1.6 0.397 0.0373 2.25 2.7242 0.9859 1909528 Bionet1_002567 Fc1cccc(Cl)c1/C=N/Nc2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M10 compound treatment 0.378 0.0263 1.34 0.398 0.0383 2.31 2.5861 0.9666 1909529 Bionet1_002568 CC(=O)/C(=C/Nc1ccc(I)cc1)/c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M11 compound treatment 0.35 -0.00172 -0.09 0.355 -0.00468 -0.28 -0.2618 -0.8853 1909530 Bionet1_002569 FC(F)(F)c1cc(c2ccc3nnc(c4ccccc4)n3c2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M12 compound treatment 0.357 0.00528 0.27 0.364 0.00432 0.26 0.3755 0.9999 1909531 Bionet1_002570 CCSc1nnc(c2cccn(Cc3ccc(Cl)cc3Cl)c2=O)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M13 compound treatment 0.424 0.0723 3.7 0.43 0.0703 4.25 5.6153 0.9976 1909532 Bionet1_002571 FC(F)(F)c1nc2ccccc2nc1N/N=C/c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M14 compound treatment 0.355 0.00328 0.17 0.372 0.0123 0.74 0.6446 0.8454 1909533 Bionet1_002572 CC(=O)/C(=C\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)/c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M15 compound treatment 0.363 0.0113 0.58 0.359 -6.77E-4 -0.04 0.379 0.6553 1909534 Bionet1_002573 Cc1ccc(cc1)c2nnc3ccc4c(cc(nc4n23)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M16 compound treatment 0.381 0.0293 1.5 0.385 0.0253 1.53 2.1396 0.9999 1909535 Bionet1_002574 COc1ccc(cc1OC)/C(=C\Nc2ccc(Cl)cc2Cl)/C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M17 compound treatment 0.419 0.0673 3.44 0.425 0.0653 3.94 5.221 0.9977 1909536 Bionet1_002575 FC(F)(F)c1nc2ccccc2nc1N/N=C/c3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M18 compound treatment 0.375 0.0233 1.19 0.377 0.0173 1.05 1.5812 0.9979 1909537 Bionet1_002576 CCOC(=O)c1ccc(N/C=C(\C(=O)C)/c2ccc(OC)c(OC)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M19 compound treatment 0.358 0.00628 0.32 0.367 0.00732 0.44 0.5397 0.9877 1909538 Bionet1_002577 FC(F)(F)c1cc(c2ccc3nnc(n4cccc4)n3c2n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M20 compound treatment 0.36 0.00828 0.42 0.368 0.00832 0.5 0.6547 0.9964 1909539 Bionet1_002578 COc1ccc(cc1OC)/C(=C/Nc2ccc(Oc3ccccc3)cc2)/C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M21 compound treatment 0.36 0.00828 0.42 0.361 0.00132 0.08 0.3559 0.8259 1909540 Bionet1_002579 Fc1cccc(Cl)c1c2nnc3c(cc4cccnc4n23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M22 compound treatment 0.367 0.0153 0.78 0.372 0.0123 0.74 1.0785 0.9997 1909541 Bionet1_002580 COc1ccc(cc1OC)/C(=C/Nc2ccc(cc2)C(F)(F)F)/C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M23 positive control 0.088 -0.264 -13.48 0.091 -0.269 -16.22 -21.004 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 M24 positive control 0.095 -0.257 -13.13 0.098 -0.262 -15.8 -20.4521 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N01 mock treatment 0.352 2.81E-4 0.01 0.357 -0.00268 -0.16 -0.1041 -0.6417 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N02 mock treatment 0.349 -0.00272 -0.14 0.368 0.00832 0.5 0.257 0.4929 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N03 compound treatment 0.345 -0.00672 -0.34 0.361 0.00132 0.08 -0.1865 -0.5287 1738874 Bionet1_002581 CC(C)(CNS(=O)(=O)c1ccc(Cl)cc1)SCc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N04 compound treatment 0.347 -0.00472 -0.24 0.357 -0.00268 -0.16 -0.2849 -0.981 1909542 Bionet1_002582 CSc1nnc(C)c(/C=C/Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N05 compound treatment 0.362 0.0103 0.53 0.366 0.00632 0.38 0.6416 0.9876 1909543 Bionet1_002583 FC(F)(F)c1cnc(N/N=C/C(=O)c2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N06 compound treatment 0.368 0.0163 0.83 0.377 0.0173 1.05 1.3281 0.9936 1909544 Bionet1_002584 Cc1nnc(SCC=C)nc1/C=C/Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N07 compound treatment 0.348 -0.00372 -0.19 0.352 -0.00768 -0.46 -0.4622 -0.9226 1367731 Bionet1_002585 CC(C)(CNC(=O)c1c(Cl)cccc1Cl)SCc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N08 compound treatment 0.335 -0.0167 -0.85 0.364 0.00432 0.26 -0.42 -0.4699 1909545 Bionet1_002586 Cc1nnc(SCC=C)nc1/C=C/NOCc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N09 compound treatment 0.349 -0.00272 -0.14 0.357 -0.00268 -0.16 -0.2126 -0.9972 1909546 Bionet1_002587 CC(C)(CNC(=O)c1cccc(c1)[N+](=O)[O-])SCc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N10 compound treatment 0.362 0.0103 0.53 0.371 0.0113 0.68 0.8551 0.9916 1909547 Bionet1_002588 FC(F)(F)c1cccc(Oc2ccc(cn2)C(=O)NC3CCSC3=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N11 compound treatment 0.376 0.0243 1.24 0.368 0.00832 0.5 1.2332 0.9207 1909548 Bionet1_002589 Oc1nc(cc(c1C#N)c2ccc(Cl)cc2Cl)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N12 compound treatment 0.346 -0.00572 -0.29 0.374 0.0143 0.86 0.4046 0.4433 1909549 Bionet1_002590 CCCSc1nnc(C)c(/C=C/Nc2cccc(c2)C(F)(F)F)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N13 compound treatment 0.393 0.0413 2.11 0.402 0.0423 2.55 3.2992 0.9955 1909550 Bionet1_002591 Cc1ccc(cc1)c2cc(c(C#N)c(O)n2)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N14 compound treatment 0.37 0.0183 0.93 0.379 0.0193 1.17 1.4858 0.994 1909551 Bionet1_002592 COc1ccc(N/C=C/c2nc(SCc3ccccc3)nnc2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N15 compound treatment 0.357 0.00528 0.27 0.353 -0.00668 -0.4 -0.0941 -0.1939 1909552 Bionet1_002593 Cc1ccc(cc1)c2cc(nc(O)c2C#N)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N16 compound treatment 0.374 0.0223 1.14 0.387 0.0273 1.65 1.9719 0.9837 1909553 Bionet1_002594 Cc1nnc(SCc2ccccc2)nc1/C=C/Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N17 compound treatment 0.349 -0.00272 -0.14 0.357 -0.00268 -0.16 -0.2126 -0.9972 1909554 Bionet1_002595 CNC(=O)CSCC(=O)Nc1cc(OC(C)C)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N18 compound treatment 0.367 0.0153 0.78 0.379 0.0193 1.17 1.3773 0.981 1909555 Bionet1_002596 Cc1nnc(SCc2ccccc2)nc1/C=C/Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N19 compound treatment 0.35 -0.00172 -0.09 0.361 0.00132 0.08 -0.0057 -0.0479 1909556 Bionet1_002597 CNC(=O)CS(=O)CC(=O)Nc1cc(OC(C)C)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N20 compound treatment 0.35 -0.00172 -0.09 0.353 -0.00668 -0.4 -0.3472 -0.8415 1909557 Bionet1_002598 Cc1nnc(SCc2ccccc2)nc1/C=C/NOCc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N21 compound treatment 0.36 0.00828 0.42 0.367 0.00732 0.44 0.612 0.9998 1909558 Bionet1_002599 CNC(=O)CS(=O)(=O)CC(=O)Nc1cc(OC(C)C)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N22 compound treatment 0.351 -7.19E-4 -0.04 0.352 -0.00768 -0.46 -0.3537 -0.7608 1909559 Bionet1_002600 COc1ccc(N/C=C/c2nc(SCc3ccc(Cl)cc3)nnc2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N23 positive control 0.092 -0.26 -13.28 0.091 -0.269 -16.22 -20.8594 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 N24 positive control 0.094 -0.258 -13.18 0.097 -0.263 -15.86 -20.531 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O01 mock treatment 0.354 0.00228 0.12 0.362 0.00232 0.14 0.1816 0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O02 mock treatment 0.353 0.00128 0.07 0.363 0.00332 0.2 0.1882 0.8917 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O03 compound treatment 0.356 0.00428 0.22 0.37 0.0103 0.62 0.5954 0.9015 1909560 Bionet1_002601 FC(F)(F)c1nc2ccccc2n3c(nnc13)c4c(Cl)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O04 compound treatment 0.355 0.00328 0.17 0.366 0.00632 0.38 0.3885 0.9319 1909561 Bionet1_002602 COc1ccc(cc1OC)/C(=C/Nc2cccc(Br)c2)/C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O05 compound treatment 0.362 0.0103 0.53 0.373 0.0133 0.8 0.9404 0.9788 1909562 Bionet1_002603 COc1ccc(cc1)C(=O)NNc2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O06 compound treatment 0.401 0.0493 2.52 0.404 0.0443 2.68 3.6738 0.9996 1909563 Bionet1_002604 COc1ccc(N/C=C(\C(=O)C)/c2ccc(OC)c(OC)c2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O07 compound treatment 0.373 0.0213 1.09 0.382 0.0223 1.35 1.7223 0.9944 1909564 Bionet1_002605 [O-][N+](=O)c1cc(/C=N/Nc2nc3ccccc3nc2C(F)(F)F)ccc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O08 compound treatment 0.356 0.00428 0.22 0.378 0.0183 1.11 0.9369 0.8309 1909565 Bionet1_002606 CC1(C)NC(=NC(=C1)/C=C/c2c(Cl)cccc2Cl)SCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O09 compound treatment 0.373 0.0213 1.09 0.387 0.0273 1.65 1.9358 0.9796 1909566 Bionet1_002607 [O-][N+](=O)c1cc(ccc1Cl)c2nnc3c(nc4ccccc4n23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O10 compound treatment 0.362 0.0103 0.53 0.37 0.0103 0.62 0.8124 0.9964 1909567 Bionet1_002608 CC1(C)NC(=NC(=C1)/C=C/c2ccc(Cl)cc2Cl)SCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O11 compound treatment 0.381 0.0293 1.5 0.383 0.0233 1.41 2.0543 0.9995 1909568 Bionet1_002609 COc1ccc(cc1)C(=O)NN(C)c2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O12 compound treatment 0.367 0.0153 0.78 0.368 0.00832 0.5 0.9078 0.9772 1909569 Bionet1_002610 CC(C)SC1=NC(=CC(C)(C)N1)/C=C/c2c(Cl)cccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O13 compound treatment 0.383 0.0313 1.6 0.395 0.0353 2.13 2.6388 0.99 1909570 Bionet1_002611 CN(NC(=O)c1ccc(C)cc1)c2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O14 compound treatment 0.372 0.0203 1.04 0.377 0.0173 1.05 1.4727 1.0 1909571 Bionet1_002612 CC(C)SC1=NC(=CC(C)(C)N1)/C=C/c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O15 compound treatment 0.388 0.0363 1.86 0.41 0.0503 3.04 3.4599 0.972 1909572 Bionet1_002613 COc1ccc(cc1)C2=CC(=O)N(Nc3ncc(cc3Cl)C(F)(F)F)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O16 compound treatment 0.356 0.00428 0.22 0.364 0.00432 0.26 0.3393 0.9962 1319319 Bionet1_002614 COc1cc(c(Cl)cc1Cl)n2c(S)nc3cc(Cl)ccc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O17 compound treatment 0.398 0.0463 2.37 0.407 0.0473 2.86 3.6934 0.9956 1909573 Bionet1_002615 COc1ccc(cc1)C2=CC(=O)N(Nc3ccc(Cl)cc3Cl)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O18 compound treatment 0.356 0.00428 0.22 0.364 0.00432 0.26 0.3393 0.9962 1510896 Bionet1_002616 COc1cc(c(Cl)cc1Cl)n2c(S)nc3ccc(C)cc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O19 compound treatment 0.418 0.0663 3.39 0.422 0.0623 3.76 5.0568 0.9986 1909574 Bionet1_002617 Clc1ccc(cc1)C2=CC(=O)N(Nc3ccc(Cl)cc3Cl)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O20 compound treatment 0.371 0.0193 0.99 0.379 0.0193 1.17 1.522 0.9965 1443260 Bionet1_002618 CC(C)Oc1cc(c(Cl)cc1Cl)n2c(S)nc3ccccc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O21 compound treatment 0.376 0.0243 1.24 0.382 0.0223 1.35 1.8308 0.9992 1909575 Bionet1_002619 CN(NS(=O)(=O)c1ccccc1)c2nc3ccccc3nc2C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O22 compound treatment 0.365 0.0133 0.68 0.366 0.00632 0.38 0.7501 0.9629 1909576 Bionet1_002620 CCOC(=O)CSc1nnc(c2ccccc2SC)n1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O23 positive control 0.089 -0.263 -13.43 0.096 -0.264 -15.92 -20.7544 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 O24 positive control 0.096 -0.256 -13.08 0.098 -0.262 -15.8 -20.416 -0.9956 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P01 mock treatment 0.364 0.0123 0.63 0.369 0.00932 0.56 0.842 0.9985 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P02 mock treatment 0.357 0.00528 0.27 0.36 3.23E-4 0.02 0.2047 0.7561 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P03 compound treatment 0.371 0.0193 0.99 0.358 -0.00168 -0.1 0.6255 0.6312 1909577 Bionet1_002621 CC(C)Oc1cc(NC(=O)CSCC(=O)N(C)C)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P04 compound treatment 0.363 0.0113 0.58 0.378 0.0183 1.11 1.19 0.9539 1909578 Bionet1_002622 Cc1ccc(N/C=C/c2nc(SCc3ccc(Cl)cc3)nnc2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P05 compound treatment 0.358 0.00628 0.32 0.374 0.0143 0.86 0.8385 0.9091 1909579 Bionet1_002623 CC(C)Oc1cc(NC(=O)CS(=O)CC(=O)N(C)C)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P06 compound treatment 0.365 0.0133 0.68 0.368 0.00832 0.5 0.8355 0.989 1909580 Bionet1_002624 Cc1nnc(SCc2ccc(Cl)cc2)nc1/C=C/Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P07 compound treatment 0.356 0.00428 0.22 0.362 0.00232 0.14 0.2539 0.9768 1909581 Bionet1_002625 CNC(=O)CSCC(=O)Nc1cc(OCCOC)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P08 compound treatment 0.359 0.00728 0.37 0.37 0.0103 0.62 0.7039 0.9697 1909582 Bionet1_002626 CSc1nnc(C)c(/C=C/NOCc2ccc(Cl)cc2Cl)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P09 compound treatment 0.357 0.00528 0.27 0.364 0.00432 0.26 0.3755 0.9999 1909583 Bionet1_002627 CNC(=O)CS(=O)CC(=O)Nc1cc(OCCOC)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P10 compound treatment 0.352 2.81E-4 0.01 0.383 0.0233 1.41 1.0057 0.7143 1228714 Bionet1_002628 Clc1ccc(CC(=O)NCCS(=O)c2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P11 compound treatment 0.346 -0.00572 -0.29 0.368 0.00832 0.5 0.1485 0.2554 1909584 Bionet1_002629 COCCOc1cc(NC(=O)CSCC(=O)N(C)C)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P12 compound treatment 0.372 0.0203 1.04 0.383 0.0233 1.41 1.7289 0.9887 1909585 Bionet1_002630 CSc1nnc(C)c(/C=C/NOCc2cccc(Cl)c2Cl)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P13 compound treatment 0.366 0.0143 0.73 0.386 0.0263 1.59 1.64 0.9378 1909586 Bionet1_002631 CCN(CC)C(=O)CSCC(=O)Nc1cc(OC)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P14 compound treatment 0.364 0.0123 0.63 0.374 0.0143 0.86 1.0554 0.9877 1909587 Bionet1_002632 Fc1ccc(/C=C/2\SC(=S)N(N3C(=O)c4ccccc4C3=O)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P15 compound treatment 0.362 0.0103 0.53 0.361 0.00132 0.08 0.4282 0.8053 1909588 Bionet1_002633 CCN(CC)C(=O)CS(=O)CC(=O)Nc1cc(OC)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P16 compound treatment 0.368 0.0163 0.83 0.378 0.0183 1.11 1.3708 0.9902 1724601 Bionet1_002634 COc1cccc(c1)c2nc(nc(N3CCN(C)CC3)c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P17 compound treatment 0.368 0.0163 0.83 0.381 0.0213 1.29 1.4989 0.9778 1909589 Bionet1_002635 COc1cc(NC(=S)NC(=O)c2csnn2)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P18 compound treatment 0.362 0.0103 0.53 0.364 0.00432 0.26 0.5562 0.9478 1537313 Bionet1_002636 CN1CCN(CC1)c2nc(nc(c2C#N)c3ccc(C)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P19 compound treatment 0.383 0.0313 1.6 0.393 0.0333 2.01 2.5534 0.9935 1909590 Bionet1_002637 Cn1nc(c(/C=N/O)c1Sc2ccc(cc2)C(C)(C)C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P20 compound treatment 0.348 -0.00372 -0.19 0.378 0.0183 1.11 0.6477 0.5771 1702113 Bionet1_002638 CN1CCN(CC1)c2nc(nc(c2C#N)c3ccc(F)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P21 compound treatment 0.346 -0.00572 -0.29 0.361 0.00132 0.08 -0.1503 -0.4959 1909591 Bionet1_002639 Cn1nc(c(/C=N/O)c1Sc2cccc(c2)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P22 compound treatment 0.347 -0.00472 -0.24 0.356 -0.00368 -0.22 -0.3276 -0.9991 1548153 Bionet1_002640 COc1ccccc1c2nc(nc(N3CCN(C)CC3)c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P23 positive control 0.09 -0.262 -13.38 0.094 -0.266 -16.04 -20.8037 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.575 P24 positive control 0.097 -0.255 -13.02 0.11 -0.25 -15.07 -19.8676 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A01 mock treatment 0.321 -0.0387 -1.98 0.324 -0.0268 -1.62 -2.5441 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A02 mock treatment 0.329 -0.0307 -1.57 0.326 -0.0248 -1.5 -2.1695 -0.9997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A03 compound treatment 0.332 -0.0277 -1.42 0.338 -0.0128 -0.78 -1.5487 -0.9598 1333022 Bionet1_002641 CC(C)c1ccc(cc1)C2Nc3cc(C)c(C)cc3NC4=C2C(=O)CC(C)(C)C4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A04 compound treatment 0.323 -0.0367 -1.88 0.324 -0.0268 -1.62 -2.4718 -0.9973 1909592 Bionet1_002642 Cn1nc(c(C#N)c1Sc2cccc(c2)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A05 compound treatment 0.35 -0.00968 -0.49 0.344 -0.00684 -0.41 -0.6418 -0.9959 1144365 Bionet1_002643 Cc1cc2NC(C3=C(CC(C)(C)CC3=O)Nc2cc1C)c4cccc(O)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A06 compound treatment 0.331 -0.0287 -1.47 0.325 -0.0258 -1.56 -2.1398 -0.9995 1909593 Bionet1_002644 Cn1nc(c(/C=N/O)c1Sc2ccc(Br)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A07 compound treatment 0.331 -0.0287 -1.47 0.324 -0.0268 -1.62 -2.1825 -0.9988 1411009 Bionet1_002645 CCOC(=O)c1cc(nnc1Sc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A08 compound treatment 0.324 -0.0357 -1.82 0.314 -0.0368 -2.22 -2.8625 -0.9952 1909594 Bionet1_002646 CNc1cc(CSC)nc(SCc2ccc(Cl)c(Cl)c2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A09 compound treatment 0.336 -0.0237 -1.21 0.33 -0.0208 -1.26 -1.7456 -0.9998 1909595 Bionet1_002647 CC(C)C(NC(=O)c1sc(C)nc1C(F)(F)F)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A10 compound treatment 0.33 -0.0297 -1.52 0.318 -0.0328 -1.98 -2.4748 -0.9913 1227541 Bionet1_002648 CSCc1cc(NCC=C)nc(SCc2ccc(Cl)c(Cl)c2)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A11 compound treatment 0.344 -0.0157 -0.8 0.345 -0.00584 -0.35 -0.8161 -0.9319 1909596 Bionet1_002649 CC(C(=O)c1c[nH]c(c1)C(=O)NCC=C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A12 compound treatment 0.325 -0.0347 -1.77 0.321 -0.0298 -1.8 -2.5275 -1.0 1909597 Bionet1_002650 CO/N=C/c1c(Sc2ccc(Cl)cc2)n(C)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A13 compound treatment 0.338 -0.0217 -1.11 0.33 -0.0208 -1.26 -1.6733 -0.998 1909598 Bionet1_002651 FC(F)(F)c1cnc(CCC(=O)N2CCN(CC2)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A14 compound treatment 0.335 -0.0247 -1.26 0.325 -0.0258 -1.56 -1.9952 -0.9945 1909599 Bionet1_002652 CNc1cc(CSC)nc(SCc2ccc(Cl)cc2Cl)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A15 compound treatment 0.307 -0.0527 -2.69 0.303 -0.0478 -2.89 -3.9467 -0.9994 1909600 Bionet1_002653 CN(C)c1nc(N(C)C)n(n1)S(=O)(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A16 compound treatment 0.329 -0.0307 -1.57 0.322 -0.0288 -1.74 -2.3402 -0.9986 1909601 Bionet1_002654 CSCc1cc(nc(SCc2ccc(Cl)cc2Cl)n1)N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A17 compound treatment 0.348 -0.0117 -0.6 0.333 -0.0178 -1.08 -1.1837 -0.9613 1909602 Bionet1_002655 [O-][N+](=O)c1ccc(cc1)N2CCc3c(C#N)c(sc3C2)n4cccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A18 compound treatment 0.339 -0.0207 -1.06 0.335 -0.0158 -0.96 -1.4237 -0.9987 1909603 Bionet1_002656 CO/N=C/c1c(Sc2ccccc2C(=O)OC)n(C)nc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A19 compound treatment 0.333 -0.0267 -1.36 0.322 -0.0288 -1.74 -2.1956 -0.9927 1909604 Bionet1_002657 CC1(OCCO1)c2ccc([N+](=O)[O-])c(CS(=O)(=O)c3ccccc3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A20 compound treatment 0.326 -0.0337 -1.72 0.322 -0.0288 -1.74 -2.4487 -1.0 1909605 Bionet1_002658 Cn1nc(c(C#N)c1Sc2ccc(Br)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A21 compound treatment 0.427 0.0673 3.44 0.401 0.0502 3.03 4.5753 0.998 1909606 Bionet1_002659 CN(C)/C=C/C(=O)c1ccc([N+](=O)[O-])c(CS(=O)(=O)c2ccccc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A22 compound treatment 0.32 -0.0397 -2.03 0.321 -0.0298 -1.8 -2.7083 -0.9982 1909607 Bionet1_002660 Oc1nc(cc(c1C#N)c2ccc(Cl)cc2)c3cccc(Br)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A23 positive control 0.086 -0.274 -13.99 0.086 -0.265 -15.99 -21.2002 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 A24 positive control 0.087 -0.273 -13.94 0.087 -0.264 -15.93 -21.1214 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B01 mock treatment 0.359 -6.77E-4 -0.03 0.353 0.00216 0.13 0.0678 0.502 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B02 mock treatment 0.372 0.0123 0.63 0.359 0.00816 0.49 0.7939 0.9926 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B03 compound treatment 0.375 0.0153 0.78 0.363 0.0122 0.73 1.0731 0.9995 1723442 Bionet1_002661 CC(C)Nc1nc(SCc2ccc(C)cc2)nc(c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B04 compound treatment 0.379 0.0193 0.99 0.368 0.0172 1.04 1.4312 0.9997 1909608 Bionet1_002662 Cn1nc(c(/C=N/OCc2ccc(Cl)cc2Cl)c1O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B05 compound treatment 0.341 -0.0187 -0.96 0.366 0.0152 0.92 -0.0281 -0.0213 1909609 Bionet1_002663 Cc1ccc(N/N=C/2\C(=O)N(CN3CCOCC3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B06 compound treatment 0.366 0.00632 0.32 0.361 0.0102 0.61 0.6624 0.9552 1909610 Bionet1_002664 Cn1nc(c(/C=N/OCc2ccc(Cl)cc2Cl)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B07 compound treatment 0.38 0.0203 1.04 0.37 0.0192 1.16 1.5527 0.9986 1909611 Bionet1_002665 Clc1ccc(N/N=C/2\C(=O)N(CN3CCOCC3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B08 compound treatment 0.375 0.0153 0.78 0.36 0.00916 0.55 0.9451 0.9855 1909612 Bionet1_002666 CCOc1ccc(Br)cc1/C=C/c2nc3ccccc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B09 compound treatment 0.383 0.0233 1.19 0.365 0.0142 0.85 1.4478 0.9867 1909613 Bionet1_002667 Clc1ccccc1N/N=C/2\C(=O)N(CN3CCOCC3)c4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B10 compound treatment 0.372 0.0123 0.63 0.351 1.61E-4 0.01 0.4524 0.7179 1909614 Bionet1_002668 Cn1nc(c(CCl)c1Sc2ccc(Br)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B11 compound treatment 0.422 0.0623 3.19 0.401 0.0502 3.03 4.3946 0.9997 1909615 Bionet1_002669 Fc1ccc(N/N=C/2\C(=O)N(CN3CCOCC3)c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B12 compound treatment 0.369 0.00932 0.48 0.346 -0.00484 -0.29 0.1305 0.2335 1909616 Bionet1_002670 Cc1ccc(cc1)c2cc3ccccc3nc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B13 compound treatment 0.365 0.00532 0.27 0.353 0.00216 0.13 0.2847 0.9433 1909617 Bionet1_002671 CO/N=C(/CS(=O)(=O)c1ccc(Cl)cc1)\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B14 compound treatment 0.365 0.00532 0.27 0.354 0.00316 0.19 0.3274 0.9849 1909618 Bionet1_002672 C/C(=N\Oc1cccc(O/N=C(\C)/c2ccc(F)cc2)n1)/c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B15 compound treatment 0.37 0.0103 0.53 0.358 0.00716 0.43 0.6789 0.9951 1909619 Bionet1_002673 CO/N=C(/CS(=O)Cc1ccc(Cl)cc1)\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B16 compound treatment 0.374 0.0143 0.73 0.368 0.0172 1.04 1.2504 0.9856 1909620 Bionet1_002674 FC(F)(F)c1ccc(N/N=C(/N=Nc2ccc(cc2)C(F)(F)F)\C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B17 compound treatment 0.356 -0.00368 -0.19 0.353 0.00216 0.13 -0.0407 -0.1778 1909621 Bionet1_002675 CO/N=C(/CS(=O)(=O)Cc1ccc(Cl)cc1)\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B18 compound treatment 0.362 0.00232 0.12 0.361 0.0102 0.61 0.5177 0.8286 1527210 Bionet1_002676 COC(=O)Cc1c(sc(NC(=O)c2ccccc2)c1C(=O)OC)C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B19 compound treatment 0.375 0.0153 0.78 0.351 1.61E-4 0.01 0.5609 0.7158 1909622 Bionet1_002677 CO/N=C(/CS(=O)(=O)c1ccc(OC)cc1)\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B20 compound treatment 0.389 0.0293 1.5 0.376 0.0252 1.52 2.1342 1.0 1909623 Bionet1_002678 CN(C)/C=C/C(=C\C(=O)C(F)(F)F)/Nc1ccc(Br)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B21 compound treatment 0.369 0.00932 0.48 0.364 0.0132 0.79 0.8989 0.9701 1909624 Bionet1_002679 CO/N=C(\CS(=O)Cc1ccc(OC)cc1)/c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B22 compound treatment 0.361 0.00132 0.07 0.357 0.00616 0.37 0.3108 0.8222 1909625 Bionet1_002680 COc1ccc(/C=C\2/N(Cc3ccccc3)C(=O)CN(C(=O)C)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B23 positive control 0.087 -0.273 -13.94 0.087 -0.264 -15.93 -21.1214 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 B24 positive control 0.089 -0.271 -13.84 0.086 -0.265 -15.99 -21.0918 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C01 mock treatment 0.359 -6.77E-4 -0.03 0.355 0.00416 0.25 0.1531 0.6039 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C02 mock treatment 0.371 0.0113 0.58 0.368 0.0172 1.04 1.1419 0.9622 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C03 compound treatment 0.362 0.00232 0.12 0.353 0.00216 0.13 0.1762 0.9989 1909626 Bionet1_002681 CC1(OCCO1)c2ccc([N+](=O)[O-])c(CS(=O)(=O)c3ccc(Cl)cc3)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C04 compound treatment 0.368 0.00832 0.43 0.362 0.0112 0.67 0.7774 0.9754 1909627 Bionet1_002682 Oc1nc(cc(c1C#N)c2ccc(Cl)cc2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C05 compound treatment 0.375 0.0153 0.78 0.364 0.0132 0.79 1.1158 1.0 1909628 Bionet1_002683 CCOC(=O)/C(=C(\O)/C(=C/c1ccccc1)/NC(=O)c2ccccc2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C06 compound treatment 0.37 0.0103 0.53 0.364 0.0132 0.79 0.935 0.9803 1909629 Bionet1_002684 Oc1nc(cc(c1C#N)c2ccc(Cl)cc2)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C07 compound treatment 0.369 0.00932 0.48 0.353 0.00216 0.13 0.4293 0.8687 1909630 Bionet1_002685 CC(=O)c1ccc([N+](=O)[O-])c(CS(=O)(=O)c2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C08 compound treatment 0.377 0.0173 0.89 0.377 0.0262 1.58 1.7431 0.9626 1909631 Bionet1_002686 Oc1nc(cc(c1C#N)c2ccc(Cl)cc2)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C09 compound treatment 0.361 0.00132 0.07 0.345 -0.00584 -0.35 -0.2014 -0.5612 1909632 Bionet1_002687 Fc1ccc(cc1)S(=O)(=O)NCCNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C10 compound treatment 0.377 0.0173 0.89 0.359 0.00816 0.49 0.9747 0.9617 1909633 Bionet1_002688 Oc1nc(cc(c1C#N)c2ccccc2C(F)(F)F)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C11 compound treatment 0.392 0.0323 1.65 0.375 0.0242 1.46 2.2 0.9981 1909634 Bionet1_002689 CCOC(=O)c1[nH]c2ccccc2c1NC(=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C12 compound treatment 0.373 0.0133 0.68 0.354 0.00316 0.19 0.6166 0.8716 1909635 Bionet1_002690 COc1ccc(Sc2nc(SC)nc(c2C#N)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C13 compound treatment 0.362 0.00232 0.12 0.344 -0.00684 -0.41 -0.2079 -0.4841 1909636 Bionet1_002691 COC(=O)c1ccc([N+](=O)[O-])c(CS(=O)(=O)c2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C14 compound treatment 0.369 0.00932 0.48 0.35 -8.39E-4 -0.05 0.3013 0.6285 1909637 Bionet1_002692 CSc1nc(Sc2ccc(Cl)cc2)c(C#N)c(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C15 compound treatment 0.359 -6.77E-4 -0.03 0.342 -0.00884 -0.53 -0.4018 -0.7514 1909638 Bionet1_002693 NNC(=O)c1ccc([N+](=O)[O-])c(CS(=O)(=O)c2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C16 compound treatment 0.357 -0.00268 -0.14 0.35 -8.39E-4 -0.05 -0.1326 -0.9085 1909639 Bionet1_002694 CSc1nc(Sc2cccc(Cl)c2)c(C#N)c(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C17 compound treatment 0.353 -0.00668 -0.34 0.348 -0.00284 -0.17 -0.3626 -0.9492 1909640 Bionet1_002695 COC(=O)c1ccc(c(CS(=O)(=O)c2ccc(Cl)cc2)c1)n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C18 compound treatment 0.377 0.0173 0.89 0.376 0.0252 1.52 1.7004 0.967 1909641 Bionet1_002696 FC(F)(F)c1cccc(/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C19 compound treatment 0.362 0.00232 0.12 0.354 0.00316 0.19 0.2189 0.974 1909642 Bionet1_002697 FC(F)(F)c1cnc(c(Cl)c1)n2cc3CCc4ccccc4-c3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C20 compound treatment 0.376 0.0163 0.83 0.365 0.0142 0.85 1.1947 0.9999 1909643 Bionet1_002698 FC(F)(F)c1ccc(/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C21 compound treatment 0.367 0.00732 0.37 0.356 0.00516 0.31 0.4851 0.9958 1909644 Bionet1_002699 CCOC(=O)c1ccc([N+](=O)[O-])c(CS(=O)(=O)c2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C22 compound treatment 0.361 0.00132 0.07 0.361 0.0102 0.61 0.4816 0.7803 1909645 Bionet1_002700 FC(F)(F)c1ccccc1/N=C/2\C(=O)N(c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C23 positive control 0.087 -0.273 -13.94 0.09 -0.261 -15.75 -20.9933 -0.9982 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 C24 positive control 0.091 -0.269 -13.74 0.093 -0.258 -15.57 -20.7206 -0.9981 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D01 mock treatment 0.351 -0.00868 -0.44 0.344 -0.00684 -0.41 -0.6057 -0.9994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D02 mock treatment 0.359 -6.77E-4 -0.03 0.352 0.00116 0.07 0.0251 0.3207 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D03 compound treatment 0.363 0.00332 0.17 0.357 0.00616 0.37 0.3831 0.937 1909646 Bionet1_002701 CO/N=C(\CS(=O)(=O)Cc1ccc(OC)cc1)/c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D04 compound treatment 0.358 -0.00168 -0.09 0.342 -0.00884 -0.53 -0.4379 -0.8104 1909647 Bionet1_002702 CCOC(OCC)c1ccc(/C=C/C(=O)c2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D05 compound treatment 0.363 0.00332 0.17 0.348 -0.00284 -0.17 -0.001 -0.0043 1909648 Bionet1_002703 Cn1nc(c(/C=N/c2ccc(F)c(Cl)c2F)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D06 compound treatment 0.365 0.00532 0.27 0.366 0.0152 0.92 0.8396 0.8793 1909649 Bionet1_002704 COc1ccc(N=Nc2cnc(nc2c3ccc(OC)cc3)c4ccccn4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D07 compound treatment 0.356 -0.00368 -0.19 0.347 -0.00384 -0.23 -0.2968 -0.9946 1909650 Bionet1_002705 Cn1nc(c(/C=N/c2cccc(c2)C(F)(F)F)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D08 compound treatment 0.359 -6.77E-4 -0.03 0.346 -0.00484 -0.29 -0.231 -0.7855 1909651 Bionet1_002706 Clc1ccccc1N=Nc2cnc(nc2c3ccccc3)c4ccncc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D09 compound treatment 0.355 -0.00468 -0.24 0.349 -0.00184 -0.11 -0.2476 -0.9391 1909652 Bionet1_002707 CN(NC(=O)c1cccc(c1)C(F)(F)F)c2c(C#N)c(nn2C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D10 compound treatment 0.362 0.00232 0.12 0.351 1.61E-4 0.01 0.0909 0.7625 1909653 Bionet1_002708 Clc1ccc(N=Nc2cnc(nc2c3ccco3)c4cccnc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D11 compound treatment 0.36 3.23E-4 0.02 0.347 -0.00384 -0.23 -0.1522 -0.6551 1909654 Bionet1_002709 CN(NC(=O)c1ccc(Cl)cc1Cl)c2c(C#N)c(nn2C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D12 compound treatment 0.359 -6.77E-4 -0.03 0.346 -0.00484 -0.29 -0.231 -0.7855 1909655 Bionet1_002710 CC(=O)N1CC(=O)N(Cc2ccccc2)/C(=C/c3ccc(F)cc3)/C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D13 compound treatment 0.363 0.00332 0.17 0.344 -0.00684 -0.41 -0.1718 -0.3848 1909656 Bionet1_002711 CN(NS(=O)(=O)c1ccccc1)c2c(C#N)c(nn2C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D14 compound treatment 0.384 0.0243 1.24 0.368 0.0172 1.04 1.612 0.9959 1909657 Bionet1_002712 CN(C)c1ccc(/C=C\2/N(Cc3ccccc3)C(=O)CN(C(=O)C)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D15 compound treatment 0.356 -0.00368 -0.19 0.348 -0.00284 -0.17 -0.2541 -0.9989 1677095 Bionet1_002713 COc1ccc(cc1)N(Cc2ccccc2)C(=O)c3ccc(Cl)nc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D16 compound treatment 0.352 -0.00768 -0.39 0.349 -0.00184 -0.11 -0.3561 -0.8728 1909658 Bionet1_002714 COc1ccc(cc1)c2nc(ncc2N=Nc3ccc(F)cc3)c4cccnc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D17 compound treatment 0.355 -0.00468 -0.24 0.344 -0.00684 -0.41 -0.461 -0.9663 1675002 Bionet1_002715 COc1ccc(cc1)N(Cc2ccccc2)C(=O)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D18 compound treatment 0.368 0.00832 0.43 0.346 -0.00484 -0.29 0.0944 0.1828 1719087 Bionet1_002716 Nc1nc(Cn2cncn2)nc(N)c1Cc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D19 compound treatment 0.374 0.0143 0.73 0.352 0.00116 0.07 0.5674 0.7713 1909659 Bionet1_002717 CO/N=C(/CS(=O)c1ccccc1C(=O)OC)\c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D20 compound treatment 0.359 -6.77E-4 -0.03 0.348 -0.00284 -0.17 -0.1457 -0.8332 1909660 Bionet1_002718 COc1ccc(cc1)C2CC2/C(=N/OC(=O)c3ccc(cc3)[N+](=O)[O-])/C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D21 compound treatment 0.363 0.00332 0.17 0.348 -0.00284 -0.17 -0.001 -0.0043 1909661 Bionet1_002719 CO/N=C(/CSc1ccc(Br)cc1)\c2ccc(OC)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D22 compound treatment 0.352 -0.00768 -0.39 0.342 -0.00884 -0.53 -0.6549 -0.9886 1909662 Bionet1_002720 Clc1ccc(C2CC2C(=O)c3ccc(Br)cc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D23 positive control 0.089 -0.271 -13.84 0.087 -0.264 -15.93 -21.0491 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 D24 positive control 0.089 -0.271 -13.84 0.09 -0.261 -15.75 -20.921 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E01 mock treatment 0.356 -0.00368 -0.19 0.348 -0.00284 -0.17 -0.2541 -0.9989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E02 mock treatment 0.367 0.00732 0.37 0.362 0.0112 0.67 0.7412 0.9616 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E03 compound treatment 0.369 0.00932 0.48 0.358 0.00716 0.43 0.6428 0.9988 1227893 Bionet1_002721 Nc1ccc(cc1CS(=O)(=O)c2ccc(Cl)cc2)C(=O)N3CCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E04 compound treatment 0.397 0.0373 1.91 0.391 0.0402 2.42 3.0638 0.993 1909663 Bionet1_002722 O=C/1N(c2ccccc2\C1=N\c3ccc(Oc4ccccc4)cc3)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E05 compound treatment 0.359 -6.77E-4 -0.03 0.332 -0.0188 -1.14 -0.8287 -0.7283 1909664 Bionet1_002723 NC(=O)c1ccc([N+](=O)[O-])c(CS(=O)(=O)c2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E06 compound treatment 0.362 0.00232 0.12 0.353 0.00216 0.13 0.1762 0.9989 1909665 Bionet1_002724 Clc1ccc(N/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E07 compound treatment 0.366 0.00632 0.32 0.348 -0.00284 -0.17 0.1074 0.2936 1909666 Bionet1_002725 Clc1ccc(cc1)S(=O)(=O)Cc2cc(C#N)ccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E08 compound treatment 0.356 -0.00368 -0.19 0.351 1.61E-4 0.01 -0.1261 -0.6696 1909667 Bionet1_002726 Clc1cc(Cl)cc(N/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E09 compound treatment 0.226 -0.134 -6.84 0.205 -0.146 -8.8 -11.0586 -0.9922 1909668 Bionet1_002727 Clc1ccc(cc1)S(=O)(=O)c2snnc2C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E10 compound treatment 0.377 0.0173 0.89 0.351 1.61E-4 0.01 0.6332 0.7148 1909669 Bionet1_002728 Clc1ccc(Cl)c(N/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E11 compound treatment 0.219 -0.141 -7.19 0.204 -0.147 -8.86 -11.3544 -0.9946 1909670 Bionet1_002729 Clc1ccc(cc1)S(=O)c2snnc2C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E12 compound treatment 0.368 0.00832 0.43 0.35 -8.39E-4 -0.05 0.2651 0.6186 1909671 Bionet1_002730 [O-][N+](=O)c1ccc(N/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E13 compound treatment 0.229 -0.131 -6.68 0.222 -0.129 -7.78 -10.2245 -0.9971 1315741 Bionet1_002731 Clc1ccc(cc1)S(=O)c2snnc2C(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E14 compound treatment 0.366 0.00632 0.32 0.344 -0.00684 -0.41 -0.0633 -0.1208 1909672 Bionet1_002732 CSc1nc(Sc2ccc(Cl)cc2)c(C#N)c(n1)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E15 compound treatment 0.329 -0.0307 -1.57 0.32 -0.0308 -1.86 -2.4256 -0.9964 1678768 Bionet1_002733 Clc1ccc(cc1)S(=O)c2snnc2C(=O)N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E16 compound treatment 0.36 3.23E-4 0.02 0.347 -0.00384 -0.23 -0.1522 -0.6551 1909673 Bionet1_002734 CSc1nc(Sc2cccc(C)c2)c(C#N)c(n1)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E17 compound treatment 0.366 0.00632 0.32 0.35 -8.39E-4 -0.05 0.1928 0.5892 1909674 Bionet1_002735 Clc1ccc(Sc2snnc2C(=O)OC3CCCCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E18 compound treatment 0.371 0.0113 0.58 0.366 0.0152 0.92 1.0566 0.9756 1909675 Bionet1_002736 Oc1nc(SCc2ccccc2Cl)nc(c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E19 compound treatment 0.367 0.00732 0.37 0.352 0.00116 0.07 0.3143 0.8252 1646308 Bionet1_002737 Clc1ccc(cc1)S(=O)(=O)c2snnc2C(=O)N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E20 compound treatment 0.383 0.0233 1.19 0.37 0.0192 1.16 1.6612 0.9999 1909676 Bionet1_002738 Oc1nc(SCc2cccc(c2)C(F)(F)F)nc(c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E21 compound treatment 0.374 0.0143 0.73 0.354 0.00316 0.19 0.6528 0.8626 1739634 Bionet1_002739 Clc1ccc(cc1)S(=O)(=O)c2snnc2C(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E22 compound treatment 0.369 0.00932 0.48 0.358 0.00716 0.43 0.6428 0.9988 1909677 Bionet1_002740 Cc1ccc(cc1)c2nc(SCc3ccccc3)nc(Cl)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E23 positive control 0.09 -0.27 -13.79 0.086 -0.265 -15.99 -21.0556 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 E24 positive control 0.092 -0.268 -13.69 0.093 -0.258 -15.57 -20.6845 -0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F01 mock treatment 0.357 -0.00268 -0.14 0.35 -8.39E-4 -0.05 -0.1326 -0.9085 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F02 mock treatment 0.364 0.00432 0.22 0.357 0.00616 0.37 0.4193 0.9691 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F03 compound treatment 0.366 0.00632 0.32 0.357 0.00616 0.37 0.4916 0.9976 1909678 Bionet1_002741 CO/N=C(/CS(=O)c1ccc(Br)cc1)\c2ccc(OC)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F04 compound treatment 0.362 0.00232 0.12 0.348 -0.00284 -0.17 -0.0372 -0.1784 1909679 Bionet1_002742 O/N=C(/C1CC1c2ccc(Cl)cc2)\c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F05 compound treatment 0.39 0.0303 1.55 0.381 0.0302 1.82 2.3838 0.9968 1909680 Bionet1_002743 FC(F)(F)c1cccc(CC(=O)Nc2ccc(Oc3ccccc3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F06 compound treatment 0.37 0.0103 0.53 0.351 1.61E-4 0.01 0.3801 0.72 1909681 Bionet1_002744 Cc1ccc(cc1)C2CC2/C(=N/OC(=O)c3ccc(C)cc3)/c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F07 compound treatment 0.347 -0.0127 -0.65 0.313 -0.0378 -2.28 -2.0736 -0.8733 1909682 Bionet1_002745 Clc1ccc(CN/C(=N\c2ccccc2)/NC3CCCCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F08 compound treatment 0.37 0.0103 0.53 0.35 -8.39E-4 -0.05 0.3374 0.6364 1909683 Bionet1_002746 Cc1ccc(cc1)C2CC2/C(=N/OC(=O)c3ccc(F)cc3)/c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F09 compound treatment 0.379 0.0193 0.99 0.352 0.00116 0.07 0.7482 0.7554 1339515 Bionet1_002747 Fc1ccc(cc1)C(=O)N2CCN3C(=O)c4ccccc4C23c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F10 compound treatment 0.386 0.0263 1.35 0.361 0.0102 0.61 1.3855 0.9367 1909684 Bionet1_002748 Cc1ccc(cc1)C2CC2/C(=N/OC(=O)c3ccco3)/c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F11 compound treatment 0.372 0.0123 0.63 0.354 0.00316 0.19 0.5805 0.8817 1720705 Bionet1_002749 Cc1ccc(cc1)C(=O)N2CCN3C(=O)c4ccccc4C23c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F12 compound treatment 0.363 0.00332 0.17 0.34 -0.0108 -0.65 -0.3425 -0.5067 1909685 Bionet1_002750 COc1ccc(cc1)C2CC2/C(=N/OC(=O)c3ccc(C)cc3)/c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F13 compound treatment 0.382 0.0223 1.14 0.375 0.0242 1.46 1.8385 0.9926 1909686 Bionet1_002751 Cn1nc(c(C(=O)Nc2ccc(cc2)C(F)(F)F)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F14 compound treatment 0.372 0.0123 0.63 0.348 -0.00284 -0.17 0.3244 0.4967 1909687 Bionet1_002752 COc1ccc(cc1)C2CC2/C(=N/OC(=O)c3cccs3)/c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F15 compound treatment 0.372 0.0123 0.63 0.358 0.00716 0.43 0.7512 0.9831 1909688 Bionet1_002753 Cn1nc(c(C(=O)Nc2ccc(Cl)c(Cl)c2)c1Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F16 compound treatment 0.385 0.0253 1.29 0.364 0.0132 0.79 1.4774 0.9725 1909689 Bionet1_002754 COc1ccc(cc1)C2CC2/C(=N/OC(=O)c3ccc(C)cc3)/c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F17 compound treatment 0.395 0.0353 1.81 0.37 0.0192 1.16 2.0951 0.9768 1909690 Bionet1_002755 CN(C)/C=N\C(=O)c1sc2cc(cnc2c1c3cccs3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F18 compound treatment 0.387 0.0273 1.4 0.365 0.0142 0.85 1.5924 0.9722 1909691 Bionet1_002756 Cc1onc(c1C(=O)Oc2cc(no2)c3ccccc3)c4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F19 compound treatment 0.391 0.0313 1.6 0.363 0.0122 0.73 1.6516 0.9374 1909692 Bionet1_002757 FC(F)(F)c1cnc2c(c3cccs3)c(sc2c1)c4nc[nH]n4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F20 compound treatment 0.375 0.0153 0.78 0.361 0.0102 0.61 0.9878 0.9927 1909693 Bionet1_002758 CCOC(=O)C1=NNC2C1C(=O)N(C2=O)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F21 compound treatment 0.373 0.0133 0.68 0.36 0.00916 0.55 0.8728 0.9947 1909694 Bionet1_002759 Cc1ccc(C)n1c2ccc(C#Cc3ccc(cc3)n4c(C)ccc4C)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F22 compound treatment 0.369 0.00932 0.48 0.362 0.0112 0.67 0.8135 0.9856 1909695 Bionet1_002760 CCOC(=O)C1=NNC2C1C(=O)N(C2=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F23 positive control 0.093 -0.267 -13.64 0.088 -0.263 -15.87 -20.8618 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 F24 positive control 0.093 -0.267 -13.64 0.091 -0.26 -15.69 -20.7337 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G01 mock treatment 0.345 -0.0147 -0.75 0.341 -0.00984 -0.59 -0.9507 -0.9933 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G02 mock treatment 0.357 -0.00268 -0.14 0.35 -8.39E-4 -0.05 -0.1326 -0.9085 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G03 compound treatment 0.242 -0.118 -6.02 0.227 -0.124 -7.48 -9.541 -0.9942 1909696 Bionet1_002761 Clc1ccc(cc1)S(=O)(=O)c2snnc2C(=O)OC3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G04 compound treatment 0.38 0.0203 1.04 0.377 0.0262 1.58 1.8515 0.9794 1909697 Bionet1_002762 Clc1ccccc1CSc2nc(Cl)c(C#N)c(n2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G05 compound treatment 0.373 0.0133 0.68 0.359 0.00816 0.49 0.8301 0.9873 1909698 Bionet1_002763 CCOC(=O)C1C(N=C(N=C1O)c2ccccc2)c3ccc(cc3)C(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G06 compound treatment 0.39 0.0303 1.55 0.375 0.0242 1.46 2.1277 0.9995 1909699 Bionet1_002764 Clc1ccc(CN2C(=O)/C(=N\Nc3ccccc3)/c4ccccc24)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G07 compound treatment 0.358 -0.00168 -0.09 0.346 -0.00484 -0.29 -0.2672 -0.8777 1909700 Bionet1_002765 CCOC(=O)C1C(N=C(N=C1O)c2ccccc2)c3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G08 compound treatment 0.441 0.0813 4.16 0.407 0.0562 3.39 5.3377 0.9949 1909701 Bionet1_002766 FC(F)(F)c1cccc(CN2C(=O)/C(=N/Nc3ccccc3)/c4ccccc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G09 compound treatment 0.376 0.0163 0.83 0.346 -0.00484 -0.29 0.3836 0.4338 1909702 Bionet1_002767 CCOC(=O)C1C(N=C(N=C1O)c2ccccc2)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G10 compound treatment 0.37 0.0103 0.53 0.35 -8.39E-4 -0.05 0.3374 0.6364 1909703 Bionet1_002768 Clc1ccc(N/N=C/2\C(=O)N(c3ccccc23)c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G11 compound treatment 0.351 -0.00868 -0.44 0.328 -0.0228 -1.38 -1.2887 -0.8897 1449119 Bionet1_002769 OC(c1c[nH]cc1c2c(Cl)cccc2Cl)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G12 compound treatment 0.386 0.0263 1.35 0.36 0.00916 0.55 1.3428 0.9228 1909704 Bionet1_002770 Oc1nc(SCc2c(Cl)cccc2Cl)nc(c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G13 compound treatment 0.386 0.0263 1.35 0.377 0.0262 1.58 2.0685 0.9968 1909705 Bionet1_002771 COCc1cc(nc(n1)c2ccccc2)N3CCN(CC3)c4ccccc4F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G14 compound treatment 0.379 0.0193 0.99 0.368 0.0172 1.04 1.4312 0.9997 1909706 Bionet1_002772 Cc1ccccc1CN2C(=O)N(Cc3cccc(c3)C(F)(F)F)C(=O)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G15 compound treatment 0.367 0.00732 0.37 0.339 -0.0118 -0.71 -0.2406 -0.2982 1909707 Bionet1_002773 COCc1cc(Sc2cccc(Cl)c2Cl)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G16 compound treatment 0.374 0.0143 0.73 0.355 0.00416 0.25 0.6955 0.8983 1909708 Bionet1_002774 COc1ccc(CN2C(=O)N(Cc3ccccc3C)C(=O)C2=O)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G17 compound treatment 0.36 3.23E-4 0.02 0.354 0.00316 0.19 0.1466 0.7654 1909709 Bionet1_002775 COCc1cc(Sc2c(Cl)cccc2Cl)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G18 compound treatment 0.37 0.0103 0.53 0.36 0.00916 0.55 0.7643 0.9997 1909710 Bionet1_002776 Fc1ccc(CN2C(=O)N(Cc3ccc(Cl)cc3Cl)C(=O)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G19 compound treatment 0.37 0.0103 0.53 0.347 -0.00384 -0.23 0.2094 0.3632 1909711 Bionet1_002777 COCc1cc(Sc2ccc(Cl)cc2Cl)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G20 compound treatment 0.368 0.00832 0.43 0.35 -8.39E-4 -0.05 0.2651 0.6186 1909712 Bionet1_002778 Cc1ccc(CN2C(=O)N(Cc3ccc(Cl)cc3Cl)C(=O)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G21 compound treatment 0.362 0.00232 0.12 0.352 0.00116 0.07 0.1335 0.9684 1909713 Bionet1_002779 COCc1cc(Sc2ccc(Br)cc2)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G22 compound treatment 0.363 0.00332 0.17 0.355 0.00416 0.25 0.2978 0.9819 1909714 Bionet1_002780 COc1ccccc1CN2C(=O)N(Cc3c(F)cccc3Cl)C(=O)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G23 positive control 0.09 -0.27 -13.79 0.089 -0.262 -15.81 -20.9275 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 G24 positive control 0.094 -0.266 -13.58 0.091 -0.26 -15.69 -20.6975 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H01 mock treatment 0.358 -0.00168 -0.09 0.351 1.61E-4 0.01 -0.0538 -0.6228 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H02 mock treatment 0.367 0.00732 0.37 0.36 0.00916 0.55 0.6558 0.982 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H03 compound treatment 0.361 0.00132 0.07 0.356 0.00516 0.31 0.2681 0.841 1909715 Bionet1_002781 FC(F)(F)c1cnc2c(c3cccs3)c(sc2c1)C(=O)NCC#C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H04 compound treatment 0.364 0.00432 0.22 0.356 0.00516 0.31 0.3766 0.9859 1909716 Bionet1_002782 CCOC(=O)C1=NNC2C1C(=O)N(C2=O)c3ccsc3C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H05 compound treatment 0.381 0.0213 1.09 0.369 0.0182 1.1 1.5462 1.0 1909717 Bionet1_002783 Cn1c(S)nnc1c2sc3cc(cnc3c2c4cccs4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H06 compound treatment 0.357 -0.00268 -0.14 0.352 0.00116 0.07 -0.0472 -0.3071 1909718 Bionet1_002784 Clc1ccc(c(Cl)c1)S(=O)(=O)Oc2cc(no2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H07 compound treatment 0.358 -0.00168 -0.09 0.337 -0.0138 -0.84 -0.6514 -0.7756 1909719 Bionet1_002785 FC(F)(F)c1cnc(c2cc(on2)C(=O)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H08 compound treatment 0.372 0.0123 0.63 0.355 0.00416 0.25 0.6232 0.9187 1909720 Bionet1_002786 CCOC(=O)C1=NOC(C1)C(=O)NN(C)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H09 compound treatment 0.359 -6.77E-4 -0.03 0.348 -0.00284 -0.17 -0.1457 -0.8332 1909721 Bionet1_002787 Cn1c(S)nnc1c2sc3cc(cnc3c2c4ccccc4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H10 compound treatment 0.378 0.0183 0.94 0.353 0.00216 0.13 0.7547 0.7979 1909722 Bionet1_002788 CCOC(=O)C1C(C1C(=O)Nc2cccc(c2)C(F)(F)F)C(=O)NN 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H11 compound treatment 0.37 0.0103 0.53 0.365 0.0142 0.85 0.9777 0.9731 1909723 Bionet1_002789 Cn1c(S)nnc1c2sc3cc(cnc3c2c4cccnc4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H12 compound treatment 0.388 0.0283 1.45 0.375 0.0242 1.46 2.0554 1.0 1909724 Bionet1_002790 CCOC(=O)C1C2C1C(=O)N(N(C)c3ncc(cc3Cl)C(F)(F)F)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H13 compound treatment 0.378 0.0183 0.94 0.361 0.0102 0.61 1.0962 0.9789 1909725 Bionet1_002791 Cn1c(S)nnc1c2sc3cc(cnc3c2c4ccccn4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H14 compound treatment 0.382 0.0223 1.14 0.353 0.00216 0.13 0.8994 0.7828 1909726 Bionet1_002792 CCOC(=O)C1C(C1C(=O)N2CCCC2)C(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H15 compound treatment 0.379 0.0193 0.99 0.356 0.00516 0.31 0.9189 0.887 1909727 Bionet1_002793 CSc1nnc([nH]1)c2sc3cc(cnc3c2c4cccs4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H16 compound treatment 0.382 0.0223 1.14 0.361 0.0102 0.61 1.2408 0.9576 1909728 Bionet1_002794 CCOC(=O)C1C(C1C(=O)OCC)C(=O)Nc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H17 compound treatment 0.396 0.0363 1.86 0.372 0.0212 1.28 2.2166 0.9833 1909729 Bionet1_002795 FC(F)(F)c1cnc2c(c(sc2c1)C(=O)N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H18 compound treatment 0.386 0.0263 1.35 0.369 0.0182 1.1 1.727 0.9948 1909730 Bionet1_002796 CCOC(=O)C1C(C1C(=O)Nc2cccc(c2)C(F)(F)F)C(=O)NC(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H19 compound treatment 0.39 0.0303 1.55 0.361 0.0102 0.61 1.5301 0.9177 1909731 Bionet1_002797 CN(C)/C=N/C(=O)c1sc2cc(cnc2c1c3ccccc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H20 compound treatment 0.415 0.0553 2.83 0.4 0.0492 2.97 4.0988 0.9997 1909732 Bionet1_002798 [O-][N+](=O)c1ccc(cc1)N2CCN(CCOC(=O)Nc3ccccc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H21 compound treatment 0.372 0.0123 0.63 0.362 0.0112 0.67 0.922 0.9994 1909733 Bionet1_002799 FC(F)(F)c1cccc(c1)C(=O)n2sc(NC(=O)c3ccccc3)nc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H22 compound treatment 0.377 0.0173 0.89 0.364 0.0132 0.79 1.1881 0.9985 1909734 Bionet1_002800 [O-][N+](=O)c1ccc(cc1)N2CCN(CCOC(=O)c3ccc(F)cc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H23 positive control 0.091 -0.269 -13.74 0.089 -0.262 -15.81 -20.8914 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 H24 positive control 0.093 -0.267 -13.64 0.092 -0.259 -15.63 -20.691 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I01 mock treatment 0.354 -0.00568 -0.29 0.342 -0.00884 -0.53 -0.5826 -0.9591 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I02 mock treatment 0.361 0.00132 0.07 0.354 0.00316 0.19 0.1828 0.9027 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I03 compound treatment 0.366 0.00632 0.32 0.356 0.00516 0.31 0.4489 0.9998 1909735 Bionet1_002801 COCc1cc(SCc2ccc(Cl)cc2Cl)nc(n1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I04 compound treatment 0.359 -6.77E-4 -0.03 0.349 -0.00184 -0.11 -0.103 -0.8856 1909736 Bionet1_002802 [O-][N+](=O)c1ccc(CN2C(=O)N(Cc3ccccc3Cl)C(=O)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I05 compound treatment 0.4 0.0403 2.06 0.392 0.0412 2.48 3.215 0.9957 1909737 Bionet1_002803 [O-][N+](=O)c1ccc(cc1)C(=O)OCc2ccc(Oc3ccccc3)c(c2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I06 compound treatment 0.363 0.00332 0.17 0.346 -0.00484 -0.29 -0.0864 -0.2557 1909738 Bionet1_002804 Clc1cccc(CN2C(=O)N(Cc3c(Cl)cccc3Cl)C(=O)C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I07 compound treatment 0.367 0.00732 0.37 0.349 -0.00184 -0.11 0.1863 0.477 1909739 Bionet1_002805 [O-][N+](=O)c1cc(COC(=O)Nc2ccc(Cl)cc2)ccc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I08 compound treatment 0.394 0.0343 1.75 0.379 0.0282 1.7 2.4431 0.9999 1909740 Bionet1_002806 Clc1cccc(CN2C(=O)N(Cc3cccc(Cl)c3)C(=O)C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I09 compound treatment 0.375 0.0153 0.78 0.361 0.0102 0.61 0.9878 0.9927 1909741 Bionet1_002807 Cc1ccc(Oc2ccc(COC(=O)c3ccc(Cl)cc3)cc2[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I10 compound treatment 0.362 0.00232 0.12 0.344 -0.00684 -0.41 -0.2079 -0.4841 1909742 Bionet1_002808 Clc1cccc(CN2C(=O)N(CCOc3ccccc3)C(=O)C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I11 compound treatment 0.372 0.0123 0.63 0.358 0.00716 0.43 0.7512 0.9831 1909743 Bionet1_002809 [O-][N+](=O)c1cc(COC(=O)c2ccc(Cl)cc2)ccc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I12 compound treatment 0.355 -0.00468 -0.24 0.347 -0.00384 -0.23 -0.333 -0.9999 1909744 Bionet1_002810 COc1ccccc1CN2C(=O)N(CC(=O)c3ccc(F)cc3)C(=O)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I13 compound treatment 0.383 0.0233 1.19 0.359 0.00816 0.49 1.1916 0.9235 1909745 Bionet1_002811 [O-][N+](=O)c1cc(COC(=O)Nc2cccc(Cl)c2)ccc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I14 compound treatment 0.369 0.00932 0.48 0.351 1.61E-4 0.01 0.344 0.7214 1909746 Bionet1_002812 Clc1ccccc1C(=O)CN2C(=O)N(Cc3ccccc3)C(=O)C2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I15 compound treatment 0.405 0.0453 2.32 0.378 0.0272 1.64 2.7981 0.9856 1909747 Bionet1_002813 Fc1ccc(NC(=O)c2nnsc2Sc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I16 compound treatment 0.407 0.0473 2.42 0.386 0.0352 2.12 3.2119 0.9979 1909748 Bionet1_002814 O=C(CN1C(=O)N(Cc2ccccc2)C(=O)C1=O)c3ccc(cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I17 compound treatment 0.383 0.0233 1.19 0.36 0.00916 0.55 1.2343 0.939 1909749 Bionet1_002815 Fc1ccc(NC(=O)c2nnsc2Sc3ccc(Cl)cc3)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I18 compound treatment 0.389 0.0293 1.5 0.359 0.00816 0.49 1.4086 0.8925 1909750 Bionet1_002816 Cc1cc(C)c(CN2C(=O)N(Cc3ccccc3F)C(=O)C2=O)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I19 compound treatment 0.238 -0.122 -6.22 0.209 -0.142 -8.56 -10.454 -0.9877 1909751 Bionet1_002817 Fc1ccc(NC(=O)c2nnsc2S(=O)(=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I20 compound treatment 0.381 0.0213 1.09 0.351 1.61E-4 0.01 0.7778 0.7134 1909752 Bionet1_002818 CCOC(=O)CN1C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I21 compound treatment 0.394 0.0343 1.75 0.38 0.0292 1.76 2.4858 1.0 1909753 Bionet1_002819 Clc1ccccc1/C=C/NC(=O)OCc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I22 compound treatment 0.368 0.00832 0.43 0.352 0.00116 0.07 0.3505 0.8126 1909754 Bionet1_002820 CCOC(=O)CN1C(=O)N(Cc2ccc(cc2)C(F)(F)F)C(=O)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I23 positive control 0.092 -0.268 -13.69 0.09 -0.261 -15.75 -20.8125 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 I24 positive control 0.094 -0.266 -13.58 0.095 -0.256 -15.44 -20.5268 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J01 mock treatment 0.352 -0.00768 -0.39 0.345 -0.00584 -0.35 -0.5268 -0.9986 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J02 mock treatment 0.365 0.00532 0.27 0.355 0.00416 0.25 0.3701 0.9992 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J03 compound treatment 0.359 -6.77E-4 -0.03 0.353 0.00216 0.13 0.0678 0.502 1497526 Bionet1_002821 Cc1ccc(cc1)C(=O)Nc2nc(=O)n(s2)C(=O)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J04 compound treatment 0.406 0.0463 2.37 0.39 0.0392 2.36 3.3465 1.0 1909755 Bionet1_002822 [O-][N+](=O)c1ccc(cc1)N2CCN(CCOC(=O)c3cccc(Cl)c3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J05 compound treatment 0.365 0.00532 0.27 0.355 0.00416 0.25 0.3701 0.9992 1283584 Bionet1_002823 Cc1ccc(cc1)C(=O)Nc2nc(=O)n(s2)C(=O)c3ccccc3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J06 compound treatment 0.352 -0.00768 -0.39 0.345 -0.00584 -0.35 -0.5268 -0.9986 1909756 Bionet1_002824 CN(NS(=O)(=O)c1ccc(F)cc1)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J07 compound treatment 0.347 -0.0127 -0.65 0.343 -0.00784 -0.47 -0.793 -0.988 1909757 Bionet1_002825 CC(C)(C)/C(=N\OC(=O)NC1CCCCC1)/COc2ccccc2[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J08 compound treatment 0.351 -0.00868 -0.44 0.337 -0.0138 -0.84 -0.9045 -0.9562 1909758 Bionet1_002826 FC(F)(F)c1cccc(c1)N2C(=O)CC(C2=O)c3c[nH]c4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J09 compound treatment 0.357 -0.00268 -0.14 0.351 1.61E-4 0.01 -0.0899 -0.6552 1909759 Bionet1_002827 Cc1ccc(OC/C(=N/OC(=O)NC2CCCCC2)/C(C)(C)C)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J10 compound treatment 0.358 -0.00168 -0.09 0.347 -0.00384 -0.23 -0.2245 -0.9086 1632313 Bionet1_002828 CC(=O)Nc1ccc(Sc2ccccc2C(=O)Nc3ccc(F)cc3)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J11 compound treatment 0.378 0.0183 0.94 0.366 0.0152 0.92 1.3097 0.9999 1556791 Bionet1_002829 Clc1ccc(cc1)c2cc(COc3cc(Cl)cc(Cl)c3)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J12 compound treatment 0.357 -0.00268 -0.14 0.328 -0.0228 -1.38 -1.0717 -0.7735 1909760 Bionet1_002830 COc1ccc2[nH]cc(C3CC(=O)N(C3=O)c4cccc(c4)C(F)(F)F)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J13 compound treatment 0.406 0.0463 2.37 0.373 0.0222 1.34 2.6208 0.9634 1705222 Bionet1_002831 Clc1ccccc1c2cc(COc3cc(Cl)c(Cl)cc3Cl)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J14 compound treatment 0.365 0.00532 0.27 0.345 -0.00584 -0.35 -0.0568 -0.1275 1508650 Bionet1_002832 Clc1ccc(N2C(=O)CC(C2=O)c3c[nH]c4ccccc34)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J15 compound treatment 0.393 0.0333 1.7 0.38 0.0292 1.76 2.4496 0.9999 1239805 Bionet1_002833 Clc1cc(Cl)c(OCc2cc(no2)c3ccccc3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J16 compound treatment 0.38 0.0203 1.04 0.363 0.0122 0.73 1.2539 0.9855 1399121 Bionet1_002834 O=c1ccn(nc1c2ccn(n2)C3CCS(=O)(=O)C3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J17 compound treatment 0.378 0.0183 0.94 0.352 0.00116 0.07 0.712 0.7579 1384706 Bionet1_002835 COc1ccc(cc1)c2cc(COc3cc(Cl)c(Cl)cc3Cl)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J18 compound treatment 0.379 0.0193 0.99 0.357 0.00616 0.37 0.9616 0.9109 1492859 Bionet1_002836 Cc1ccc(cc1)C(=O)n2ccc(n2)c3nn(ccc3=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J19 compound treatment 0.365 0.00532 0.27 0.356 0.00516 0.31 0.4128 0.9977 1281653 Bionet1_002837 Clc1ccc(cc1)c2cc(COc3cc(Cl)c(Cl)cc3Cl)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J20 compound treatment 0.38 0.0203 1.04 0.347 -0.00384 -0.23 0.5709 0.5362 1693854 Bionet1_002838 Fc1ccc(cc1)C(=O)n2ccc(n2)c3nn(ccc3=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J21 compound treatment 0.383 0.0233 1.19 0.368 0.0172 1.04 1.5758 0.9975 1119437 Bionet1_002839 COc1ccc(cc1)c2cc(COc3ccc(Cl)c(Cl)c3)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J22 compound treatment 0.379 0.0193 0.99 0.374 0.0232 1.4 1.6873 0.9855 1909761 Bionet1_002840 FC(F)(F)c1cccc(c1)n2ccc(=O)c(n2)c3ccn(n3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J23 positive control 0.094 -0.266 -13.58 0.089 -0.262 -15.81 -20.7829 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 J24 positive control 0.101 -0.259 -13.23 0.094 -0.257 -15.5 -20.3164 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K01 mock treatment 0.35 -0.00968 -0.49 0.343 -0.00784 -0.47 -0.6845 -0.9998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K02 mock treatment 0.357 -0.00268 -0.14 0.352 0.00116 0.07 -0.0472 -0.3071 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K03 compound treatment 0.359 -6.77E-4 -0.03 0.344 -0.00684 -0.41 -0.3164 -0.7638 1576316 Bionet1_002841 Cc1ccc(Sc2ncccc2COC(=O)Nc3c(C)cccc3C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K04 compound treatment 0.368 0.00832 0.43 0.356 0.00516 0.31 0.5212 0.9883 1909762 Bionet1_002842 Cc1cccc(CN2C(=O)N(OCc3cccc(Cl)c3)C(=O)C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K05 compound treatment 0.37 0.0103 0.53 0.353 0.00216 0.13 0.4655 0.8561 1506044 Bionet1_002843 Cc1ccccc1NC(=O)OCc2cccnc2Oc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K06 compound treatment 0.359 -6.77E-4 -0.03 0.348 -0.00284 -0.17 -0.1457 -0.8332 1909763 Bionet1_002844 CCOC(=O)CN1C(=O)N(Cc2ccc(Cl)c(Cl)c2)C(=O)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K07 compound treatment 0.386 0.0263 1.35 0.365 0.0142 0.85 1.5562 0.976 1367652 Bionet1_002845 Clc1ccc(Sc2ncccc2COC(=O)Nc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K08 compound treatment 0.368 0.00832 0.43 0.346 -0.00484 -0.29 0.0944 0.1828 1909764 Bionet1_002846 CCOC(=O)CN1C(=O)N(Cc2c(Cl)cccc2Cl)C(=O)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K09 compound treatment 0.399 0.0393 2.01 0.37 0.0192 1.16 2.2397 0.9655 1328691 Bionet1_002847 Clc1ccc(Sc2ncccc2COC(=O)NC3CCCCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K10 compound treatment 0.386 0.0263 1.35 0.368 0.0172 1.04 1.6843 0.9916 1909765 Bionet1_002848 COc1ccc(CN2C(=O)N(Cc3ccc(Cl)cc3)C(=O)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K11 compound treatment 0.404 0.0443 2.27 0.382 0.0312 1.88 2.9327 0.9957 1909766 Bionet1_002849 COc1ccc(COC(=O)N/C=C/c2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K12 compound treatment 0.364 0.00432 0.22 0.355 0.00416 0.25 0.3339 0.998 1909767 Bionet1_002850 COc1ccc(CN2C(=O)N(Cc3ccc(Cl)cc3)C(=O)C2=O)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K13 compound treatment 0.372 0.0123 0.63 0.351 1.61E-4 0.01 0.4524 0.7179 1909768 Bionet1_002851 Clc1ccc(CNC(=O)N/C=C/c2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K14 compound treatment 0.359 -6.77E-4 -0.03 0.343 -0.00784 -0.47 -0.3591 -0.7568 1909769 Bionet1_002852 FC(F)(F)c1cccc(CN2C(=O)N(Cc3ccc(Cl)cc3)C(=O)C2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K15 compound treatment 0.384 0.0243 1.24 0.372 0.0212 1.28 1.7827 0.9999 1909770 Bionet1_002853 Clc1cccc(CNC(=O)N/C=C/c2ccc(Cl)c(Cl)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K16 compound treatment 0.409 0.0493 2.52 0.404 0.0532 3.21 4.0526 0.9929 1909771 Bionet1_002854 CCOC(=O)c1sc2nccc(N(C)C)c2c1N/C=N/OCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K17 compound treatment 0.395 0.0353 1.81 0.386 0.0352 2.12 2.7781 0.9968 1422768 Bionet1_002855 Cc1ccccc1NC(=O)OCc2cccnc2Sc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K18 compound treatment 0.383 0.0233 1.19 0.357 0.00616 0.37 1.1063 0.8856 1909772 Bionet1_002856 CN(C)c1ccnc(c1C#N)n2cccc2/C=N/OCc3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K19 compound treatment 0.377 0.0173 0.89 0.357 0.00616 0.37 0.8893 0.9257 1665165 Bionet1_002857 COc1ccccc1CNc2cc(CSc3ccc(Cl)cc3)nc(C)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K20 compound treatment 0.377 0.0173 0.89 0.35 -8.39E-4 -0.05 0.5905 0.6656 1909773 Bionet1_002858 CN(C)c1ccnc(c1C#N)n2cccc2/C=N/OCc3cccc(F)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K21 compound treatment 0.359 -6.77E-4 -0.03 0.347 -0.00384 -0.23 -0.1884 -0.8039 1909774 Bionet1_002859 Cc1nc(CSc2ccccc2)cc(OCc3ccc(Cl)cc3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K22 compound treatment 0.377 0.0173 0.89 0.356 0.00516 0.31 0.8466 0.9017 1909775 Bionet1_002860 COc1ccccc1CO/N=C/c2cccn2c3nccc(N(C)C)c3C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K23 positive control 0.1 -0.26 -13.28 0.089 -0.262 -15.81 -20.566 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 K24 positive control 0.096 -0.264 -13.48 0.093 -0.258 -15.57 -20.5399 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L01 mock treatment 0.359 -6.77E-4 -0.03 0.346 -0.00484 -0.29 -0.231 -0.7855 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L02 mock treatment 0.364 0.00432 0.22 0.352 0.00116 0.07 0.2059 0.8878 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L03 compound treatment 0.373 0.0133 0.68 0.351 1.61E-4 0.01 0.4886 0.7171 1909776 Bionet1_002861 Clc1ccc(NC(=O)OCCNS(=O)(=O)c2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L04 compound treatment 0.377 0.0173 0.89 0.362 0.0112 0.67 1.1028 0.9909 1239273 Bionet1_002862 Clc1ccc(cc1)n2ccc(=O)c(n2)c3ccn(n3)C(=O)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L05 compound treatment 0.393 0.0333 1.7 0.349 -0.00184 -0.11 1.1263 0.6596 1189276 Bionet1_002863 Cc1ccc(cc1)n2ncc(Cl)c(Oc3ccc4ccccc4c3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L06 compound treatment 0.386 0.0263 1.35 0.364 0.0132 0.79 1.5135 0.9684 1349583 Bionet1_002864 Clc1ccc(cc1)n2ccc(=O)c(n2)c3ccn(n3)C(=O)Nc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L07 compound treatment 0.438 0.0783 4.0 0.409 0.0582 3.51 5.3146 0.9978 1909777 Bionet1_002865 COc1ccc(/C=C(\C#N)/c2nc(cs2)c3ccc(Cl)cc3)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L08 compound treatment 0.372 0.0123 0.63 0.353 0.00216 0.13 0.5378 0.8358 1909778 Bionet1_002866 Fc1ccccc1n2ccc(n2)c3nn(ccc3=O)c4cccc(c4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L09 compound treatment 0.438 0.0783 4.0 0.417 0.0662 3.99 5.6561 1.0 1909779 Bionet1_002867 COc1ccc(cc1)c2csc(n2)/C(=C/c3ccc(OC)c(OC)c3)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L10 compound treatment 0.377 0.0173 0.89 0.359 0.00816 0.49 0.9747 0.9617 1344113 Bionet1_002868 CN(N)c1nc(cc(C)c1S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L11 compound treatment 0.412 0.0523 2.68 0.396 0.0452 2.73 3.8196 1.0 1909780 Bionet1_002869 COc1ccc(/C=C(\C#N)/c2nc(cs2)c3ccc(F)cc3)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L12 compound treatment 0.367 0.00732 0.37 0.352 0.00116 0.07 0.3143 0.8252 1909781 Bionet1_002870 COc1cccc(c1)C(=O)NN(C)c2nc(C)cc(C)c2S(=O)(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L13 compound treatment 0.37 0.0103 0.53 0.363 0.0122 0.73 0.8924 0.9869 1909782 Bionet1_002871 C/C(=N\OCc1cccc(c1)C(F)(F)F)/c2sc3ncnn3c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L14 compound treatment 0.369 0.00932 0.48 0.349 -0.00184 -0.11 0.2586 0.5283 1909783 Bionet1_002872 CN(NC(=O)c1c(F)cccc1F)c2nc(C)cc(C)c2S(=O)(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L15 compound treatment 0.377 0.0173 0.89 0.352 0.00116 0.07 0.6759 0.7607 1909784 Bionet1_002873 Cc1c(sc2ncnn12)C(=O)CSCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L16 compound treatment 0.466 0.106 5.44 0.444 0.0932 5.62 7.821 0.9999 1909785 Bionet1_002874 Cc1ccc(Sc2[nH]c(nc2/C=N/Nc3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L17 compound treatment 0.373 0.0133 0.68 0.356 0.00516 0.31 0.702 0.9372 1909786 Bionet1_002875 CN(N1C(=O)C2C3CC(C=C3)C2C1=O)c4ncc(cc4Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L18 compound treatment 0.417 0.0573 2.93 0.396 0.0452 2.73 4.0004 0.9993 1909787 Bionet1_002876 Cc1ccc(Sc2[nH]c(nc2/C=N/c3ccc(C)c(C)c3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L19 compound treatment 0.396 0.0363 1.86 0.38 0.0292 1.76 2.5581 0.9996 1463955 Bionet1_002877 COc1ccc(NC(=O)c2ccccc2Sc3ccc(NC(=O)C)nc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L20 compound treatment 0.364 0.00432 0.22 0.353 0.00216 0.13 0.2485 0.9684 1909788 Bionet1_002878 CN(NC(=O)C(C)(C)C)c1nc(cc(C)c1S(=O)(=O)C)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L21 compound treatment 0.369 0.00932 0.48 0.358 0.00716 0.43 0.6428 0.9988 1621763 Bionet1_002879 COc1ccc(cc1)C2CC(Cn3cc(C#N)c(=O)n(C)c3=O)ON2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L22 compound treatment 0.365 0.00532 0.27 0.354 0.00316 0.19 0.3274 0.9849 1909789 Bionet1_002880 CN(NC(=O)C1CC1)c2nc(cc(C)c2S(=O)(=O)C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L23 positive control 0.092 -0.268 -13.69 0.09 -0.261 -15.75 -20.8125 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 L24 positive control 0.095 -0.265 -13.53 0.096 -0.255 -15.38 -20.448 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M01 mock treatment 0.361 0.00132 0.07 0.351 1.61E-4 0.01 0.0547 0.8007 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M02 mock treatment 0.366 0.00632 0.32 0.358 0.00716 0.43 0.5343 0.9897 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M03 compound treatment 0.358 -0.00168 -0.09 0.346 -0.00484 -0.29 -0.2672 -0.8777 1909790 Bionet1_002881 Cc1nc(CSc2ccccc2)cc(OCc3ccc(Cl)cc3Cl)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M04 compound treatment 0.376 0.0163 0.83 0.363 0.0122 0.73 1.1093 0.998 1909791 Bionet1_002882 CN(C)c1ccnc(c1C#N)n2cccc2/C=N/OCc3ccc(F)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M05 compound treatment 0.351 -0.00868 -0.44 0.347 -0.00384 -0.23 -0.4776 -0.9541 1233696 Bionet1_002883 Cc1nc(CSc2ccc(Cl)cc2)cc(NCc3ccc(Cl)cc3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M06 compound treatment 0.383 0.0233 1.19 0.365 0.0142 0.85 1.4478 0.9867 1909792 Bionet1_002884 CN(C)C(=C(C#N)C#N)C/C=N/Nc1ncc(cc1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M07 compound treatment 0.35 -0.00968 -0.49 0.345 -0.00584 -0.35 -0.5991 -0.9862 1660394 Bionet1_002885 Cc1nc(CS(=O)c2ccc(Cl)cc2)cc(n1)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M08 compound treatment 0.401 0.0413 2.11 0.379 0.0282 1.7 2.6962 0.9942 1909793 Bionet1_002886 CN(C)C(=C(C#N)C#N)/C=C/Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M09 compound treatment 0.359 -6.77E-4 -0.03 0.348 -0.00284 -0.17 -0.1457 -0.8332 1909794 Bionet1_002887 COc1ccc(SCc2c(Cl)n(C)nc2CSc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M10 compound treatment 0.374 0.0143 0.73 0.352 0.00116 0.07 0.5674 0.7713 1909795 Bionet1_002888 CN(C)C(=C(C#N)C#N)/C=C/Nc1ccc(I)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M11 compound treatment 0.372 0.0123 0.63 0.362 0.0112 0.67 0.922 0.9994 1724480 Bionet1_002889 COc1ccc(Oc2cc(CS(=O)c3ccc(Cl)cc3)nc(C)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M12 compound treatment 0.368 0.00832 0.43 0.348 -0.00284 -0.17 0.1797 0.3918 1909796 Bionet1_002890 CN(C)c1ccnc(Nc2ccc(I)cc2)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M13 compound treatment 0.364 0.00432 0.22 0.349 -0.00184 -0.11 0.0778 0.3146 1258850 Bionet1_002891 Cc1nc(CSc2ccc(Cl)cc2)cc(NCc3ccccc3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M14 compound treatment 0.383 0.0233 1.19 0.357 0.00616 0.37 1.1063 0.8856 1909797 Bionet1_002892 CN(C)C(=C(C#N)C#N)C/C=N/OCC(=O)N1CCN(CC1)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M15 compound treatment 0.374 0.0143 0.73 0.352 0.00116 0.07 0.5674 0.7713 1269012 Bionet1_002893 Cc1nc(CSc2ccc(Cl)cc2)cc(NCc3ccccc3Cl)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M16 compound treatment 0.368 0.00832 0.43 0.356 0.00516 0.31 0.5212 0.9883 1909798 Bionet1_002894 CN(C)C(=C(C#N)C#N)C/C=N/OCCOc1cccc(c1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M17 compound treatment 0.379 0.0193 0.99 0.356 0.00516 0.31 0.9189 0.887 1909799 Bionet1_002895 COc1cccc(c1)n2nc(c3ccnn3c4ccccc4)c(=O)n(C)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M18 compound treatment 0.401 0.0413 2.11 0.381 0.0302 1.82 2.7816 0.9973 1909800 Bionet1_002896 Cc1ccc(CN2C(=O)/C(=N/Nc3ccc(Cl)cc3)/c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M19 compound treatment 0.372 0.0123 0.63 0.357 0.00616 0.37 0.7085 0.9684 1909801 Bionet1_002897 COc1cccc(c1)n2nc(c3ccnn3c4ccc(C)cc4)c(=O)n(C)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M20 compound treatment 0.369 0.00932 0.48 0.352 0.00116 0.07 0.3866 0.8025 1909802 Bionet1_002898 Cc1ccc(CN2C(=O)/C(=N/Nc3cccc(F)c3)/c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M21 compound treatment 0.366 0.00632 0.32 0.359 0.00816 0.49 0.577 0.9791 1909803 Bionet1_002899 COc1cccc(c1)n2nc(c3ccnn3c4ccc(F)cc4)c(=O)n(C)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M22 compound treatment 0.372 0.0123 0.63 0.357 0.00616 0.37 0.7085 0.9684 1909804 Bionet1_002900 CSc1nc(/C=C/c2ccc(C)cc2)cc(\C=C/c3ccc(C)cc3)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M23 positive control 0.093 -0.267 -13.64 0.089 -0.262 -15.81 -20.8191 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 M24 positive control 0.098 -0.262 -13.38 0.093 -0.258 -15.57 -20.4675 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N01 mock treatment 0.359 -6.77E-4 -0.03 0.351 1.61E-4 0.01 -0.0176 -0.4894 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N02 mock treatment 0.358 -0.00168 -0.09 0.353 0.00216 0.13 0.0316 0.2024 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N03 compound treatment 0.352 -0.00768 -0.39 0.341 -0.00984 -0.59 -0.6976 -0.9798 1909805 Bionet1_002901 FC(F)(F)c1cccc(c1)C(=O)Nc2ccc(I)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N04 compound treatment 0.352 -0.00768 -0.39 0.352 0.00116 0.07 -0.228 -0.5718 1402942 Bionet1_002902 COc1ccc(cc1)S(=O)(=O)NCc2cc(no2)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N05 compound treatment 0.401 0.0413 2.11 0.387 0.0362 2.18 3.0377 0.9999 1909806 Bionet1_002903 CCOC(=O)NC(=O)/C(=C/Nc1ccc(I)cn1)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N06 compound treatment 0.359 -6.77E-4 -0.03 0.339 -0.0118 -0.71 -0.5299 -0.7405 1909807 Bionet1_002904 Clc1ccc(cc1)S(=O)(=O)NCc2cc(no2)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N07 compound treatment 0.39 0.0303 1.55 0.374 0.0232 1.4 2.085 0.9987 1408542 Bionet1_002905 COc1ccc(NC(=O)Nc2ccc(I)cn2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N08 compound treatment 0.358 -0.00168 -0.09 0.344 -0.00684 -0.41 -0.3526 -0.8362 1540478 Bionet1_002906 COc1ccc(cc1)c2cc(CNS(=O)(=O)c3ccc(F)cc3)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N09 compound treatment 0.427 0.0673 3.44 0.415 0.0642 3.87 5.173 0.9983 1909808 Bionet1_002907 Ic1ccc(NC(=S)NC(=O)c2ccccc2)nc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N10 compound treatment 0.42 0.0603 3.08 0.4 0.0492 2.97 4.2796 0.9998 1732565 Bionet1_002908 Cc1cc(nc(Cl)c1S(=O)(=O)c2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N11 compound treatment 0.382 0.0223 1.14 0.369 0.0182 1.1 1.5823 0.9998 1737757 Bionet1_002909 Clc1ccc(cc1)c2cnc3ccc(I)cn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N12 compound treatment 0.35 -0.00968 -0.49 0.334 -0.0168 -1.02 -1.0687 -0.9453 1357422 Bionet1_002910 Cc1cccc(Cl)c1S(=O)(=O)NCc2cc(no2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N13 compound treatment 0.398 0.0383 1.96 0.384 0.0332 2.0 2.8011 0.9999 1909809 Bionet1_002911 Fc1ccc(cc1)c2csc(Nc3ccc(I)cn3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N14 compound treatment 0.378 0.0183 0.94 0.364 0.0132 0.79 1.2243 0.9966 1909810 Bionet1_002912 Clc1ccc(cc1)c2cc(CNS(=O)(=O)c3ccc(Cl)cc3)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N15 compound treatment 0.364 0.00432 0.22 0.352 0.00116 0.07 0.2059 0.8878 1731679 Bionet1_002913 CC(=O)Nc1ccc(Sc2ccccc2C(=O)NCCc3ccccc3)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N16 compound treatment 0.368 0.00832 0.43 0.357 0.00616 0.37 0.5639 0.9977 1260919 Bionet1_002914 COc1ccc(CS(=O)c2nc(C)cc(C)c2S(=O)(=O)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N17 compound treatment 0.357 -0.00268 -0.14 0.346 -0.00484 -0.29 -0.3034 -0.9404 1909811 Bionet1_002915 COCCCNC(=O)c1ccccc1Sc2ccc(NC(=O)C)nc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N18 compound treatment 0.362 0.00232 0.12 0.35 -8.39E-4 -0.05 0.0482 0.3731 1185968 Bionet1_002916 COc1ccc(CS(=O)(=O)c2nc(C)cc(C)c2S(=O)(=O)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N19 compound treatment 0.389 0.0293 1.5 0.373 0.0222 1.34 2.0062 0.9984 1120589 Bionet1_002917 CC(=O)Nc1ccc(Sc2ncccc2C(=O)Nc3ccc(F)cc3)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N20 compound treatment 0.353 -0.00668 -0.34 0.341 -0.00984 -0.59 -0.6614 -0.9654 1909812 Bionet1_002918 Clc1cccc(c1Cl)S(=O)(=O)NCc2cc(no2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N21 compound treatment 0.361 0.00132 0.07 0.355 0.00416 0.25 0.2255 0.8666 1608181 Bionet1_002919 COc1ccc(NC(=O)c2cccnc2Sc3ccc(NC(=O)C)nc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N22 compound treatment 0.361 0.00132 0.07 0.354 0.00316 0.19 0.1828 0.9027 1131498 Bionet1_002920 COc1ccc(OC)c(c1)S(=O)(=O)NCc2cc(no2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N23 positive control 0.091 -0.269 -13.74 0.089 -0.262 -15.81 -20.8914 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 N24 positive control 0.097 -0.263 -13.43 0.092 -0.259 -15.63 -20.5464 -0.9972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O01 mock treatment 0.369 0.00932 0.48 0.412 0.0612 3.69 2.9479 0.7918 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O02 mock treatment 0.366 0.00632 0.32 0.358 0.00716 0.43 0.5343 0.9897 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O03 compound treatment 0.416 0.0563 2.88 0.395 0.0442 2.67 3.9215 0.9993 1909813 Bionet1_002921 CN(C)c1ccc(/C=N/NC(=O)c2[nH]c3ccccc3c2c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O04 compound treatment 0.369 0.00932 0.48 0.356 0.00516 0.31 0.5574 0.9788 1622811 Bionet1_002922 CC(C)Nc1nc(SCc2ccccc2)nc(c1C#N)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O05 compound treatment 0.57 0.21 10.75 0.555 0.204 12.32 16.3194 0.9977 1909814 Bionet1_002923 N/C(=C(/C#N)\C(=S)Nc1ccccc1)/N2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O06 compound treatment 0.365 0.00532 0.27 0.35 -8.39E-4 -0.05 0.1566 0.5658 1679707 Bionet1_002924 Cc1ccc(cc1)c2nc(SCc3ccccc3)nc(NCC=C)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O07 compound treatment 0.404 0.0443 2.27 0.398 0.0472 2.85 3.6157 0.9936 1909815 Bionet1_002925 FC(F)(F)c1c(c2ccccc2)c3cc(Cl)ccc3n1Cc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O08 compound treatment 0.362 0.00232 0.12 0.349 -0.00184 -0.11 0.0055 0.0338 1635316 Bionet1_002926 CCN(CC)c1nc(SCc2ccccc2)nc(c1C#N)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O09 compound treatment 0.372 0.0123 0.63 0.363 0.0122 0.73 0.9647 0.9971 1909816 Bionet1_002927 [O-][N+](=O)c1ccc(Cn2c(C#N)c(c3ccccc3)c4cc(Cl)ccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O10 compound treatment 0.386 0.0263 1.35 0.382 0.0312 1.88 2.2819 0.9865 1909817 Bionet1_002928 CNc1nc(SCc2ccccc2Cl)nc(c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O11 compound treatment 0.357 -0.00268 -0.14 0.352 0.00116 0.07 -0.0472 -0.3071 1909818 Bionet1_002929 [O-][N+](=O)CCc1ccccc1C(=O)NNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O12 compound treatment 0.404 0.0443 2.27 0.395 0.0442 2.67 3.4876 0.9967 1909819 Bionet1_002930 Clc1ccccc1CSc2nc(NCC=C)c(C#N)c(n2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O13 compound treatment 0.328 -0.0317 -1.62 0.325 -0.0258 -1.56 -2.2483 -0.9998 1909820 Bionet1_002931 FC(F)(F)c1cnc(Cc2ccc(s2)C(=O)CCl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O14 compound treatment 0.409 0.0493 2.52 0.399 0.0482 2.91 3.8392 0.9975 1909821 Bionet1_002932 CCCNc1nc(SCc2ccccc2Cl)nc(c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O15 compound treatment 0.404 0.0443 2.27 0.404 0.0532 3.21 3.8718 0.9855 1909822 Bionet1_002933 Clc1ccc(CO/N=C/CC(=O)c2cnc(s2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O16 compound treatment 0.393 0.0333 1.7 0.384 0.0332 2.0 2.6204 0.9968 1909823 Bionet1_002934 CC(C)Nc1nc(SCc2ccccc2Cl)nc(c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O17 compound treatment 0.395 0.0353 1.81 0.384 0.0332 2.0 2.6927 0.9987 1909824 Bionet1_002935 Cc1ccc(CO/N=C/CC(=O)c2cnc(s2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O18 compound treatment 0.365 0.00532 0.27 0.352 0.00116 0.07 0.242 0.8611 1909825 Bionet1_002936 Cc1ccc(CN2C(=O)/C(=N/Nc3ccc(cc3)[N+](=O)[O-])/c4ccccc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O19 compound treatment 0.406 0.0463 2.37 0.396 0.0452 2.73 3.6026 0.9975 1909826 Bionet1_002937 Fc1ccc(CO/N=C/CC(=O)c2cnc(s2)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O20 compound treatment 0.359 -6.77E-4 -0.03 0.354 0.00316 0.19 0.1105 0.5695 1909827 Bionet1_002938 CN1C(=O)/C(=N/Nc2c(Cl)cc(cc2Cl)C(F)(F)F)/c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O21 compound treatment 0.364 0.00432 0.22 0.357 0.00616 0.37 0.4193 0.9691 1909828 Bionet1_002939 FC(F)(F)c1cccc(N/C=C/C(=O)c2cnc(s2)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O22 compound treatment 0.364 0.00432 0.22 0.359 0.00816 0.49 0.5047 0.9346 1269128 Bionet1_002940 Cc1ccc(CSc2nc(NCC=C)c(C#N)c(n2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O23 positive control 0.09 -0.27 -13.79 0.087 -0.264 -15.93 -21.0129 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 O24 positive control 0.094 -0.266 -13.58 0.093 -0.258 -15.57 -20.6122 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P01 mock treatment 0.367 0.00732 0.37 0.361 0.0102 0.61 0.6985 0.972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P02 mock treatment 0.371 0.0113 0.58 0.355 0.00416 0.25 0.587 0.9301 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P03 compound treatment 0.38 0.0203 1.04 0.359 0.00816 0.49 1.0832 0.9419 1483630 Bionet1_002941 CC(=O)Nc1ccc(Sc2ncccc2C(=O)Nc3cc(C)cc(C)c3)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P04 compound treatment 0.362 0.00232 0.12 0.358 0.00716 0.43 0.3897 0.8692 1909829 Bionet1_002942 Cc1cc(C)c(c(n1)S(=O)(=O)c2ccc(Cl)cc2)S(=O)(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P05 compound treatment 0.366 0.00632 0.32 0.361 0.0102 0.61 0.6624 0.9552 1584531 Bionet1_002943 CC(=O)Nc1ccc(Sc2ccccc2C(=O)N3CCOCC3)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P06 compound treatment 0.349 -0.0107 -0.55 0.339 -0.0118 -0.71 -0.8914 -0.9912 1909830 Bionet1_002944 Cc1cc(C)c(c(Sc2ccc(Cl)cc2)n1)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P07 compound treatment 0.369 0.00932 0.48 0.359 0.00816 0.49 0.6854 0.9999 1909831 Bionet1_002945 FC(F)(F)c1cnc(NCC(CC#N)OC(=O)c2ccco2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P08 compound treatment 0.369 0.00932 0.48 0.354 0.00316 0.19 0.472 0.9193 1909832 Bionet1_002946 Cc1cc(nc(Sc2ccc(Cl)cc2)c1S(=O)(=O)C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P09 compound treatment 0.365 0.00532 0.27 0.356 0.00516 0.31 0.4128 0.9977 1909833 Bionet1_002947 COc1ccc(cc1)C2CC(Cn3cc(C(=O)C)c(=O)[nH]c3=O)ON2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P10 compound treatment 0.382 0.0223 1.14 0.37 0.0192 1.16 1.625 1.0 1613633 Bionet1_002948 Cc1ccc(cc1)S(=O)(=O)c2c(C)cc(nc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P11 compound treatment 0.352 -0.00768 -0.39 0.341 -0.00984 -0.59 -0.6976 -0.9798 1909834 Bionet1_002949 C/C(=C/C(=O)Nc1ccc(I)cn1)/N2CCCC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P12 compound treatment 0.358 -0.00168 -0.09 0.351 1.61E-4 0.01 -0.0538 -0.6228 1909835 Bionet1_002950 Cc1cc(nc(O)c1S(=O)(=O)Cc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P13 compound treatment 0.376 0.0163 0.83 0.371 0.0202 1.22 1.4508 0.9831 1909836 Bionet1_002951 CC(=O)c1noc(C)c1C(=O)Nc2ccc(I)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P14 compound treatment 0.384 0.0243 1.24 0.374 0.0232 1.4 1.8681 0.9983 1909837 Bionet1_002952 Cc1cc(nc(Cl)c1S(=O)(=O)Cc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P15 compound treatment 0.366 0.00632 0.32 0.356 0.00516 0.31 0.4489 0.9998 1909838 Bionet1_002953 CO/N=C(\C)/c1noc(C)c1C(=O)Nc2ccc(I)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P16 compound treatment 0.376 0.0163 0.83 0.368 0.0172 1.04 1.3227 0.9943 1909839 Bionet1_002954 Cc1ccc(Sc2nc(C)cc(C)c2S(=O)(=O)c3ccc(C)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P17 compound treatment 0.338 -0.0217 -1.11 0.359 0.00816 0.49 -0.4354 -0.3589 1909840 Bionet1_002955 FC(F)(F)c1cnc(NCCN2C(=O)C3C4CC(C=C4)C3C2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P18 compound treatment 0.372 0.0123 0.63 0.372 0.0212 1.28 1.3488 0.947 1233216 Bionet1_002956 Cc1ccc(cc1)S(=O)c2nc(C)cc(C)c2S(=O)(=O)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P19 compound treatment 0.36 3.23E-4 0.02 0.348 -0.00284 -0.17 -0.1095 -0.6361 1909841 Bionet1_002957 Cc1cc(nc(SCc2ccc(Cl)c(Cl)c2)c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P20 compound treatment 0.354 -0.00568 -0.29 0.361 0.0102 0.61 0.2285 0.3367 1124505 Bionet1_002958 Sc1nnc(Cc2sc(nc2c3ccccc3)c4ccccc4)o1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P21 compound treatment 0.356 -0.00368 -0.19 0.349 -0.00184 -0.11 -0.2114 -0.9684 1909842 Bionet1_002959 FC(F)(F)c1cccc(/N=C/c2nc([nH]c2Cl)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P22 compound treatment 0.358 -0.00168 -0.09 0.347 -0.00384 -0.23 -0.2245 -0.9086 1227960 Bionet1_002960 CSc1nnc(Cc2sc(nc2c3ccccc3)c4ccccc4)o1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P23 positive control 0.091 -0.269 -13.74 0.09 -0.261 -15.75 -20.8487 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.576 P24 positive control 0.094 -0.266 -13.58 0.094 -0.257 -15.5 -20.5695 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A01 mock treatment 0.329 -0.0225 -1.15 0.329 -0.0258 -1.56 -1.9126 -0.9889 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A02 mock treatment 0.322 -0.0295 -1.51 0.321 -0.0338 -2.04 -2.5072 -0.9889 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A03 compound treatment 0.327 -0.0245 -1.25 0.333 -0.0218 -1.31 -1.8142 -0.9997 1909843 Bionet1_002961 CC(OC(=O)c1cccc(c1)C(F)(F)F)c2sc3ncnn3c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A04 compound treatment 0.327 -0.0245 -1.25 0.334 -0.0208 -1.25 -1.7715 -1.0 1909844 Bionet1_002962 Fc1ccc(NC(=O)c2ccc(=O)n(Cc3cccc(Cl)c3)c2)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A05 compound treatment 0.328 -0.0235 -1.2 0.33 -0.0248 -1.5 -1.9061 -0.994 1909845 Bionet1_002963 COC(=O)c1nn(c(Sc2ccc(OC)cc2)c1/C=N/O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A06 compound treatment 0.318 -0.0335 -1.71 0.321 -0.0338 -2.04 -2.6518 -0.9962 1909846 Bionet1_002964 FC(F)(F)c1ccc(NC(=O)c2ccc(=O)n(Cc3ccccc3)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A07 compound treatment 0.323 -0.0285 -1.46 0.333 -0.0218 -1.31 -1.9588 -0.9987 1909847 Bionet1_002965 COC(=O)c1nn(c(Sc2ccc(Cl)cc2)c1/C=N/O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A08 compound treatment 0.327 -0.0245 -1.25 0.335 -0.0198 -1.19 -1.7288 -0.9997 1177140 Bionet1_002966 CN(C(=O)c1ccc(=O)n(Cc2c(Cl)cccc2Cl)c1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A09 compound treatment 0.335 -0.0165 -0.84 0.337 -0.0178 -1.07 -1.3542 -0.9928 1909848 Bionet1_002967 COC(=O)c1nn(c(Sc2ccc(C)cc2)c1/C=N/O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A10 compound treatment 0.32 -0.0315 -1.61 0.324 -0.0308 -1.86 -2.4514 -0.9974 1408555 Bionet1_002968 Fc1cccc(Cl)c1Cn2cccc(C(=O)Nc3ccccc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A11 compound treatment 0.336 -0.0155 -0.79 0.34 -0.0148 -0.89 -1.19 -0.9982 1909849 Bionet1_002969 COC(=O)c1nn(c(Sc2ccccc2)c1/C=N/O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A12 compound treatment 0.326 -0.0255 -1.3 0.325 -0.0298 -1.8 -2.1918 -0.9875 1557351 Bionet1_002970 Fc1ccc(cc1)c2nn(c3ccc(Cl)cc3)c(=O)c4cc(F)ccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A13 compound treatment 0.327 -0.0245 -1.25 0.326 -0.0288 -1.74 -2.113 -0.987 1909850 Bionet1_002971 COC(=O)c1cc(c2ccc(Cl)cc2)n(n1)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A14 compound treatment 0.324 -0.0275 -1.4 0.322 -0.0328 -1.98 -2.3922 -0.9859 1909851 Bionet1_002972 COC(=O)C(C)NC(=O)CNS(=O)(=O)c1ccc(Br)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A15 compound treatment 0.323 -0.0285 -1.46 0.328 -0.0268 -1.62 -2.1722 -0.9986 1909852 Bionet1_002973 COC(=O)c1cc(c2ccc(Cl)cc2)n(n1)c3cc(Cl)ccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A16 compound treatment 0.324 -0.0275 -1.4 0.331 -0.0238 -1.44 -2.008 -0.9999 1611406 Bionet1_002974 Cc1cc(c2ccccc2)n(CC#C)c(=O)c1S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A17 compound treatment 0.322 -0.0295 -1.51 0.331 -0.0238 -1.44 -2.0803 -0.9997 1909853 Bionet1_002975 COC(=O)c1cc(c2ccc(Cl)cc2)n(n1)c3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A18 compound treatment 0.325 -0.0265 -1.35 0.325 -0.0298 -1.8 -2.228 -0.9902 1728286 Bionet1_002976 CCn1c(cc(C)c(c1=O)S(=O)(=O)c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A19 compound treatment 0.328 -0.0235 -1.2 0.322 -0.0328 -1.98 -2.2476 -0.9713 1909854 Bionet1_002977 COC(=O)c1cc(c2ccc(Cl)cc2)n(n1)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A20 compound treatment 0.328 -0.0235 -1.2 0.326 -0.0288 -1.74 -2.0768 -0.9837 1909855 Bionet1_002978 Fc1ccc(C(=O)Nc2ccc(CS(=O)c3ccccc3)cc2)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A21 compound treatment 0.321 -0.0305 -1.56 0.315 -0.0398 -2.4 -2.7995 -0.9781 1909856 Bionet1_002979 Clc1ccccc1c2csc(NC(=O)CN3CCSCC3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A22 compound treatment 0.323 -0.0285 -1.46 0.326 -0.0288 -1.74 -2.2576 -0.9961 1909857 Bionet1_002980 Clc1ccc(cc1)S(=O)Cc2ccc(NC(=O)c3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A23 positive control 0.088 -0.263 -13.47 0.085 -0.27 -16.29 -21.0418 -0.9956 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 A24 positive control 0.089 -0.262 -13.42 0.088 -0.267 -16.1 -20.8776 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B01 mock treatment 0.351 -4.69E-4 -0.02 0.348 -0.00677 -0.41 -0.3061 -0.7473 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B02 mock treatment 0.361 0.00953 0.49 0.355 2.26E-4 0.01 0.3543 0.7266 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B03 compound treatment 0.367 0.0155 0.79 0.374 0.0192 1.16 1.3822 0.9829 1909858 Bionet1_002981 COc1ccc(cc1)C(=O)n2ccc(n2)c3ccc(Oc4ncccn4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B04 compound treatment 0.355 0.00353 0.18 0.359 0.00423 0.26 0.3081 0.9857 1909859 Bionet1_002982 Cc1ccc(Oc2cc(Oc3ccc(C)cc3)nc(n2)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B05 compound treatment 0.363 0.0115 0.59 0.37 0.0152 0.92 1.0669 0.977 1690382 Bionet1_002983 Cc1cccc(c1)C(=O)n2ccc(n2)c3ccc(Oc4ncccn4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B06 compound treatment 0.352 5.31E-4 0.03 0.355 2.26E-4 0.01 0.0288 0.9491 1909860 Bionet1_002984 Cc1ccc(Sc2cc(nc(n2)c3ccccc3)N4CCOCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B07 compound treatment 0.362 0.0105 0.54 0.36 0.00523 0.32 0.6038 0.9676 1909861 Bionet1_002985 Nc1c(cnc2nc(SCCC(=C(F)F)F)nn12)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B08 compound treatment 0.353 0.00153 0.08 0.358 0.00323 0.19 0.1931 0.9198 1909862 Bionet1_002986 Cc1ccc(Oc2cc(Sc3ccc(C)cc3)nc(n2)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B09 compound treatment 0.351 -4.69E-4 -0.02 0.357 0.00223 0.13 0.0781 0.5719 1909863 Bionet1_002987 [O-][N+](=O)c1ccc(CC(C#N)(C#N)c2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B10 compound treatment 0.351 -4.69E-4 -0.02 0.348 -0.00677 -0.41 -0.3061 -0.7473 1605807 Bionet1_002988 Clc1ccc(SC2CCS(=O)(=O)c3sccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B11 compound treatment 0.364 0.0125 0.64 0.358 0.00323 0.19 0.5908 0.8822 1909864 Bionet1_002989 Nc1c(cnc2nc(SCCC(=C(F)F)F)nn12)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B12 compound treatment 0.352 5.31E-4 0.03 0.352 -0.00277 -0.17 -0.0992 -0.5848 1130924 Bionet1_002990 Brc1ccc(SC2CCS(=O)(=O)c3sccc23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B13 compound treatment 0.355 0.00353 0.18 0.359 0.00423 0.26 0.3081 0.9857 1909865 Bionet1_002991 Oc1ccccc1c2occc2C(=O)N/N=C/c3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B14 compound treatment 0.351 -4.69E-4 -0.02 0.355 2.26E-4 0.01 -0.0073 -0.2651 1634902 Bionet1_002992 Clc1ccc(Cl)c(SC2CCS(=O)(=O)c3sccc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B15 compound treatment 0.351 -4.69E-4 -0.02 0.356 0.00123 0.07 0.0354 0.4548 1909866 Bionet1_002993 FC(=C(F)CCSc1ccccc1C(=O)Nc2ccc(Cl)cc2)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B16 compound treatment 0.359 0.00753 0.39 0.36 0.00523 0.32 0.4954 0.9951 1909867 Bionet1_002994 COc1cccc(Sc2cc(nc(n2)c3ccccc3)N4CCOCC4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B17 compound treatment 0.427 0.0755 3.86 0.434 0.0792 4.78 6.1128 0.9944 1909868 Bionet1_002995 Nc1nc(Nc2ccc(Cl)cc2)sc1C(=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B18 compound treatment 0.357 0.00553 0.28 0.359 0.00423 0.26 0.3804 0.9987 1909869 Bionet1_002996 Clc1ccc(Sc2cc(nc(n2)c3ccccc3)N4CCOCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B19 compound treatment 0.422 0.0705 3.61 0.448 0.0932 5.63 6.5296 0.9769 1732093 Bionet1_002997 Nc1nc(Nc2ccc(Cl)cc2)sc1C(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B20 compound treatment 0.366 0.0145 0.74 0.358 0.00323 0.19 0.6631 0.8633 1909870 Bionet1_002998 Cc1nc2sccn2c1c3nnc(SCc4cccc(c4)C(F)(F)F)o3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B21 compound treatment 0.387 0.0355 1.82 0.382 0.0272 1.64 2.4469 0.9987 1641010 Bionet1_002999 Nc1nc(Nc2ccc(Cl)cc2)sc1C(=O)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B22 compound treatment 0.354 0.00253 0.13 0.357 0.00223 0.13 0.1865 0.9998 1464512 Bionet1_003000 COc1ccc(Sc2nccc(c2C#N)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B23 positive control 0.087 -0.264 -13.52 0.088 -0.267 -16.1 -20.9499 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 B24 positive control 0.089 -0.262 -13.42 0.089 -0.266 -16.04 -20.8349 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C01 mock treatment 0.349 -0.00247 -0.13 0.35 -0.00477 -0.29 -0.2931 -0.9314 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C02 mock treatment 0.371 0.0195 1.0 0.359 0.00423 0.26 0.8866 0.8601 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C03 compound treatment 0.36 0.00853 0.44 0.365 0.0102 0.62 0.745 0.9855 1909871 Bionet1_003001 COC(=O)c1cc(c2ccc(Cl)c(Cl)c2)n(n1)c3cccc(C)c3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C04 compound treatment 0.356 0.00453 0.23 0.362 0.00723 0.44 0.4723 0.9562 1909872 Bionet1_003002 Cc1c(Cl)cccc1NC(=O)c2ccc(c(c2)[N+](=O)[O-])n3ccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C05 compound treatment 0.357 0.00553 0.28 0.359 0.00423 0.26 0.3804 0.9987 1909873 Bionet1_003003 COC(=O)c1cc(c2ccc(Cl)c(Cl)c2)n(n1)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C06 compound treatment 0.357 0.00553 0.28 0.36 0.00523 0.32 0.4231 0.9985 1526532 Bionet1_003004 CNC(=O)c1cc(c2ccc(Cl)cc2)n(n1)c3cc(Cl)ccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C07 compound treatment 0.383 0.0315 1.61 0.386 0.0312 1.89 2.473 0.997 1909874 Bionet1_003005 COC(=O)c1cc(c2ccc(Cl)c(Cl)c2)n(n1)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C08 compound treatment 0.394 0.0425 2.17 0.402 0.0472 2.85 3.5537 0.9911 1909875 Bionet1_003006 COc1cccc2C=C(COc12)C(=O)Nc3cc(Cl)ccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C09 compound treatment 0.408 0.0565 2.89 0.406 0.0512 3.09 4.2306 0.9994 1909876 Bionet1_003007 COC(=O)c1cc(c2ccc(Cl)c(Cl)c2)n(n1)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C10 compound treatment 0.345 -0.00647 -0.33 0.348 -0.00677 -0.41 -0.5231 -0.9945 1345448 Bionet1_003008 COc1ccc(cc1)C2C(CN3CCCCC3)C(=O)N2c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C11 compound treatment 0.357 0.00553 0.28 0.37 0.0152 0.92 0.8499 0.8838 1909877 Bionet1_003009 CN(CC(=O)Nc1nc(cs1)c2ccc(Cl)cc2)Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C12 compound treatment 0.346 -0.00547 -0.28 0.352 -0.00277 -0.17 -0.3161 -0.9699 1909878 Bionet1_003010 CO/N=C(/CN1CCN(CC1)c2ccccc2F)\c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C13 compound treatment 0.353 0.00153 0.08 0.347 -0.00777 -0.47 -0.2765 -0.5811 1909879 Bionet1_003011 COC(=O)c1cc(c2ccccc2Cl)n(n1)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C14 compound treatment 0.369 0.0175 0.9 0.358 0.00323 0.19 0.7716 0.8411 1909880 Bionet1_003012 CN(C)C(=O)c1cc(c2ccc(Cl)cc2)n(n1)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C15 compound treatment 0.429 0.0775 3.96 0.415 0.0602 3.64 5.3741 0.9991 1909881 Bionet1_003013 COC(=O)c1cc(NC(=O)c2cccc(Cl)c2)c(=O)oc1/C=C/N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C16 compound treatment 0.37 0.0185 0.95 0.375 0.0202 1.22 1.5334 0.9921 1909882 Bionet1_003014 Clc1ccc(cc1)C(=O)Nc2ccc(/C=C/c3nc4ccccc4s3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C17 compound treatment 0.374 0.0225 1.15 0.369 0.0142 0.86 1.4219 0.9895 1909883 Bionet1_003015 CCOC(=O)c1cc(on1)c2oc(=O)c(NC(=O)c3ccccc3)cc2C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C18 compound treatment 0.351 -4.69E-4 -0.02 0.358 0.00323 0.19 0.1208 0.6154 1909884 Bionet1_003016 CCOC(=O)COn1c(nc2ccc(cc12)[N+](=O)[O-])c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C19 compound treatment 0.367 0.0155 0.79 0.369 0.0142 0.86 1.1688 0.9992 1909885 Bionet1_003017 COC(=O)c1cc(NC(=O)c2ccccc2)c(=O)oc1/C=C/Nc3nccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C20 compound treatment 0.351 -4.69E-4 -0.02 0.349 -0.00577 -0.35 -0.2634 -0.7539 1909886 Bionet1_003018 Cc1ccc(cc1)S(=O)c2snnc2c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C21 compound treatment 0.369 0.0175 0.9 0.364 0.00923 0.56 1.0277 0.9738 1306022 Bionet1_003019 O=C(Nc1cc2c(=O)n(ccc2oc1=O)c3nccs3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C22 compound treatment 0.36 0.00853 0.44 0.36 0.00523 0.32 0.5315 0.9873 1909887 Bionet1_003020 Clc1ccc(NC(=O)C2=Cc3cc(Cl)ccc3OC2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C23 positive control 0.086 -0.265 -13.57 0.089 -0.266 -16.04 -20.9434 -0.9965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 C24 positive control 0.09 -0.261 -13.37 0.091 -0.264 -15.92 -20.7134 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D01 mock treatment 0.34 -0.0115 -0.59 0.345 -0.00977 -0.59 -0.8319 -1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D02 mock treatment 0.354 0.00253 0.13 0.355 2.26E-4 0.01 0.1012 0.7773 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D03 compound treatment 0.379 0.0275 1.41 0.38 0.0252 1.52 2.0722 0.9992 1231570 Bionet1_003021 CC(C)(C)Nc1nc(N)c(s1)C(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D04 compound treatment 0.343 -0.00847 -0.43 0.357 0.00223 0.13 -0.2112 -0.4658 1909888 Bionet1_003022 FC(F)(F)c1cccc(Sc2nccc(c2C#N)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D05 compound treatment 0.437 0.0855 4.37 0.456 0.101 6.11 7.4135 0.9865 1909889 Bionet1_003023 Nc1nc(Nc2ccc(Cl)cc2)sc1C(=O)c3cccc(c3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D06 compound treatment 0.343 -0.00847 -0.43 0.347 -0.00777 -0.47 -0.6381 -0.9992 1384292 Bionet1_003024 Clc1ccc(cc1)c2ccnc(Oc3ccc(Cl)c(Cl)c3)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D07 compound treatment 0.338 -0.0135 -0.69 0.348 -0.00677 -0.41 -0.7761 -0.969 1434967 Bionet1_003025 COc1ccc(OCc2cnc(OCc3ccc(Cl)c(Cl)c3)s2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D08 compound treatment 0.36 0.00853 0.44 0.366 0.0112 0.68 0.7877 0.9773 1909890 Bionet1_003026 FC(F)(F)c1cccc(Oc2nccc(c2C#N)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D09 compound treatment 0.357 0.00553 0.28 0.353 -0.00177 -0.11 0.1243 0.4109 1508756 Bionet1_003027 Clc1ncc(COc2ccc(cc2)S(=O)(=O)N3CCOCC3)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D10 compound treatment 0.354 0.00253 0.13 0.351 -0.00377 -0.23 -0.0696 -0.2656 1909891 Bionet1_003028 COc1ccc(CSc2nccc(c2C#N)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D11 compound treatment 0.372 0.0205 1.05 0.369 0.0142 0.86 1.3496 0.995 1909892 Bionet1_003029 FC(=C(F)CCSc1ncccc1C(=O)Nc2ccc(F)cc2)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D12 compound treatment 0.352 5.31E-4 0.03 0.353 -0.00177 -0.11 -0.0565 -0.5116 1909893 Bionet1_003030 Cc1ccc(cc1)S(=O)(=O)c2cc(nc(n2)c3ccccc3)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D13 compound treatment 0.429 0.0775 3.96 0.432 0.0772 4.66 6.0998 0.9967 1909894 Bionet1_003031 CCNC(=O)NNC(=O)COc1ccc2c(C(=O)OCC)c3ccccn3c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D14 compound treatment 0.382 0.0305 1.56 0.372 0.0172 1.04 1.8392 0.9805 1287949 Bionet1_003032 COc1ccc(cc1)c2c(Oc3ccc(F)cc3)c4ccc(OC)cc4s2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D15 compound treatment 0.378 0.0265 1.36 0.369 0.0142 0.86 1.5665 0.9757 1909895 Bionet1_003033 Clc1cc(Cl)c(N/N=C/2\CCS(=O)(=O)c3sccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D16 compound treatment 0.341 -0.0105 -0.54 0.351 -0.00377 -0.23 -0.5396 -0.9276 1734112 Bionet1_003034 COc1ccc(Oc2nc(C)cc(C)c2S(=O)(=O)c3ccc(C)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D17 compound treatment 0.359 0.00753 0.39 0.365 0.0102 0.62 0.7088 0.9742 1909896 Bionet1_003035 Clc1ccc(Cl)c(N/N=C/2\CCS(=O)(=O)c3sccc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D18 compound treatment 0.344 -0.00747 -0.38 0.352 -0.00277 -0.17 -0.3885 -0.9316 1577130 Bionet1_003036 COc1ccccc1Oc2nc(cc(C)c2S(=O)(=O)C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D19 compound treatment 0.357 0.00553 0.28 0.36 0.00523 0.32 0.4231 0.9985 1909897 Bionet1_003037 Clc1ccc(N/N=C/2\CCS(=O)(=O)c3sccc23)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D20 compound treatment 0.36 0.00853 0.44 0.362 0.00723 0.44 0.6169 1.0 1168505 Bionet1_003038 Cc1cc(nc(Oc2ccc(cc2)C(C)(C)C)c1S(=O)(=O)C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D21 compound treatment 0.35 -0.00147 -0.08 0.35 -0.00477 -0.29 -0.2569 -0.8626 1307758 Bionet1_003039 Cc1ccc(CSc2nc(N3CCOCC3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D22 compound treatment 0.355 0.00353 0.18 0.354 -7.74E-4 -0.05 0.0946 0.5074 1909898 Bionet1_003040 Fc1ccc(cc1)c2ccnc(Sc3ccc(Br)cc3)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D23 positive control 0.087 -0.264 -13.52 0.089 -0.266 -16.04 -20.9072 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 D24 positive control 0.091 -0.26 -13.32 0.094 -0.261 -15.74 -20.5492 -0.9965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E01 mock treatment 0.346 -0.00547 -0.28 0.349 -0.00577 -0.35 -0.4442 -0.994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E02 mock treatment 0.364 0.0125 0.64 0.359 0.00423 0.26 0.6335 0.9185 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E03 compound treatment 0.355 0.00353 0.18 0.356 0.00123 0.07 0.18 0.9224 1909899 Bionet1_003041 O=C1C2C(/C=C/c3ccccc3)N4CSCC4C2C(=O)N1c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E04 compound treatment 0.357 0.00553 0.28 0.367 0.0122 0.74 0.7219 0.9133 1164709 Bionet1_003042 Fc1ccc(cc1)c2nn(c3ccc(F)cc3)c(=O)c4cc(F)ccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E05 compound treatment 0.349 -0.00247 -0.13 0.353 -0.00177 -0.11 -0.165 -0.9967 1605788 Bionet1_003043 Clc1cccc(c1)C2C3C(C4CSCN24)C(=O)N(C3=O)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E06 compound treatment 0.333 -0.0185 -0.94 0.342 -0.0128 -0.77 -1.213 -0.9949 1909900 Bionet1_003044 FC(F)(F)COC(=O)c1ccc(nc1)N2CCN(CC2)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E07 compound treatment 0.384 0.0325 1.66 0.383 0.0282 1.7 2.3811 0.9999 1909901 Bionet1_003045 CNc1nnc(s1)C2=NOC(CNc3ncc(cc3Cl)C(F)(F)F)C2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E08 compound treatment 0.358 0.00653 0.33 0.361 0.00623 0.38 0.5019 0.9983 1909902 Bionet1_003046 FC(F)(F)COC(=O)c1ccc(nc1)N2CCN(Cc3ccccc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E09 compound treatment 0.351 -4.69E-4 -0.02 0.362 0.00723 0.44 0.2915 0.6672 1909903 Bionet1_003047 Fc1cccc(F)c1C(=O)NCCONC(=O)c2c(F)cccc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E10 compound treatment 0.384 0.0325 1.66 0.388 0.0332 2.01 2.5945 0.9957 1909904 Bionet1_003048 FC(F)(F)c1nn(c(c1OCc2ccccc2)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E11 compound treatment 0.357 0.00553 0.28 0.354 -7.74E-4 -0.05 0.1669 0.5824 1909905 Bionet1_003049 Clc1ccc(cc1)C(=O)NCCONC(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E12 compound treatment 0.349 -0.00247 -0.13 0.361 0.00623 0.38 0.1765 0.4452 1587334 Bionet1_003050 CCOC(=O)c1nn(c2ccccc2)c(=O)cc1SC3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E13 compound treatment 0.366 0.0145 0.74 0.373 0.0182 1.1 1.3034 0.9817 1909906 Bionet1_003051 COc1ccc(cc1)N2CCN(CC2)c3ccc4nnc(n4n3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E14 compound treatment 0.357 0.00553 0.28 0.372 0.0172 1.04 0.9353 0.8679 1404442 Bionet1_003052 Cc1ccc(Sc2ccc(NC(=O)c3cccnc3Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E15 compound treatment 0.405 0.0535 2.74 0.418 0.0632 3.82 4.6344 0.9867 1909907 Bionet1_003053 CC(C)(C)NC(=O)C1Cc2ccccc2CN1c3ncccc3[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E16 compound treatment 0.35 -0.00147 -0.08 0.356 0.00123 0.07 -8.0E-4 -0.0074 1645118 Bionet1_003054 COc1ccc(COc2ccsc2C(=O)Nc3ccc(F)cc3F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E17 compound treatment 0.362 0.0105 0.54 0.36 0.00523 0.32 0.6038 0.9676 1655032 Bionet1_003055 COc1ccc(NC(=O)N2Cc3ccccc3CC2C(=O)NC(C)(C)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E18 compound treatment 0.379 0.0275 1.41 0.374 0.0192 1.16 1.8161 0.9954 1144993 Bionet1_003056 Cc1ccc(cc1)S(=O)(=O)c2ccc(NC(=O)c3ccc(F)cc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E19 compound treatment 0.364 0.0125 0.64 0.357 0.00223 0.13 0.5481 0.8372 1259874 Bionet1_003057 CC(=O)N1C(Cc2ccccc2)C(=O)N(C(Cc3ccccc3)C1=O)C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E20 compound treatment 0.348 -0.00347 -0.18 0.346 -0.00877 -0.53 -0.5 -0.895 1909908 Bionet1_003058 Cc1ccc(cc1)S(=O)(=O)c2ccc(NC(=O)C(Cl)Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E21 compound treatment 0.37 0.0185 0.95 0.356 0.00123 0.07 0.7223 0.76 1681730 Bionet1_003059 COc1ccc(cc1)C(=O)N2Cc3ccccc3CC2C(=O)NC(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E22 compound treatment 0.357 0.00553 0.28 0.358 0.00323 0.19 0.3377 0.9834 1909909 Bionet1_003060 ClCC(=O)Nc1ccc(cc1)S(=O)(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E23 positive control 0.096 -0.255 -13.06 0.091 -0.264 -15.92 -20.4964 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 E24 positive control 0.096 -0.255 -13.06 0.098 -0.257 -15.5 -20.1976 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F01 mock treatment 0.348 -0.00347 -0.18 0.353 -0.00177 -0.11 -0.2012 -0.9708 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F02 mock treatment 0.355 0.00353 0.18 0.361 0.00623 0.38 0.3934 0.9436 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F03 compound treatment 0.35 -0.00147 -0.08 0.354 -7.74E-4 -0.05 -0.0862 -0.974 1467003 Bionet1_003061 Cc1ccc(CSc2nc(N3CCCCC3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F04 compound treatment 0.358 0.00653 0.33 0.36 0.00523 0.32 0.4592 0.9996 1909910 Bionet1_003062 Fc1ccc(cc1)c2ccnc(Sc3c(Cl)cccc3Cl)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F05 compound treatment 0.374 0.0225 1.15 0.387 0.0322 1.95 2.1903 0.9687 1909911 Bionet1_003063 Clc1ccc(cc1)C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F06 compound treatment 0.361 0.00953 0.49 0.369 0.0142 0.86 0.9519 0.964 1168816 Bionet1_003064 COC(=O)c1ccccc1Sc2nccc(c2C#N)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F07 compound treatment 0.371 0.0195 1.0 0.378 0.0232 1.4 1.6976 0.9862 1909912 Bionet1_003065 Clc1ccc(cc1Cl)C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F08 compound treatment 0.393 0.0415 2.12 0.398 0.0432 2.61 3.3468 0.9948 1909913 Bionet1_003066 Cc1ccc(C/N=C/c2ccc(O)c(Cc3c(F)cccc3Cl)c2O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F09 compound treatment 0.346 -0.00547 -0.28 0.335 -0.0198 -1.19 -1.0418 -0.8497 1909914 Bionet1_003067 COc1cccc(c1)C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F10 compound treatment 0.419 0.0675 3.45 0.411 0.0562 3.39 4.8418 1.0 1909915 Bionet1_003068 COc1cccc(C/N=C/c2ccc(O)c(Cc3c(F)cccc3Cl)c2O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F11 compound treatment 0.365 0.0135 0.69 0.361 0.00623 0.38 0.755 0.9589 1909916 Bionet1_003069 Clc1cccc(c1)C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F12 compound treatment 0.367 0.0155 0.79 0.374 0.0192 1.16 1.3822 0.9829 1909917 Bionet1_003070 Oc1ccc(/C=N/Cc2ccco2)c(O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F13 compound treatment 0.378 0.0265 1.36 0.382 0.0272 1.64 2.1214 0.9955 1909918 Bionet1_003071 Clc1ccc(C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F14 compound treatment 0.37 0.0185 0.95 0.367 0.0122 0.74 1.1919 0.9924 1909919 Bionet1_003072 COC(=O)c1ccc(N2CCN(CC(=O)c3ccc(C)cc3)CC2)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F15 compound treatment 0.346 -0.00547 -0.28 0.348 -0.00677 -0.41 -0.4869 -0.9828 1326935 Bionet1_003073 CN1CCN(CC1)c2nc(SCc3ccc(C)cc3)nc4CCCCc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F16 compound treatment 0.365 0.0135 0.69 0.364 0.00923 0.56 0.8831 0.9942 1909920 Bionet1_003074 COC(=O)c1ccc(N2CCN(CC2)c3ccc(F)cc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F17 compound treatment 0.356 0.00453 0.23 0.352 -0.00277 -0.17 0.0454 0.1588 1909921 Bionet1_003075 FC(F)(F)c1ccccc1C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F18 compound treatment 0.371 0.0195 1.0 0.359 0.00423 0.26 0.8866 0.8601 1909922 Bionet1_003076 COC(=O)c1ccc(N2CCN(CC2)c3ccc(cc3)[N+](=O)[O-])c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F19 compound treatment 0.369 0.0175 0.9 0.38 0.0252 1.52 1.7107 0.9681 1484324 Bionet1_003077 CC1CN(CC(C)O1)c2nc(SCc3ccc(C)cc3)nc4CCCCc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F20 compound treatment 0.37 0.0185 0.95 0.375 0.0202 1.22 1.5334 0.9921 1909923 Bionet1_003078 COC(=O)c1ccc(N2CCN(CC2)C(=O)c3ccc(OC)cc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F21 compound treatment 0.36 0.00853 0.44 0.368 0.0132 0.8 0.873 0.9596 1502191 Bionet1_003079 Cc1ccc(CSc2nc(Oc3ccc(C)cc3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F22 compound treatment 0.365 0.0135 0.69 0.369 0.0142 0.86 1.0965 0.9943 1909924 Bionet1_003080 COC(=O)c1ccc(N2CCN(CC2)c3ccc(Cl)cc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F23 positive control 0.09 -0.261 -13.37 0.099 -0.256 -15.44 -20.3719 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 F24 positive control 0.092 -0.259 -13.27 0.099 -0.256 -15.44 -20.2996 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G01 mock treatment 0.339 -0.0125 -0.64 0.353 -0.00177 -0.11 -0.5266 -0.8145 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G02 mock treatment 0.35 -0.00147 -0.08 0.354 -7.74E-4 -0.05 -0.0862 -0.974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G03 compound treatment 0.348 -0.00347 -0.18 0.35 -0.00477 -0.29 -0.3292 -0.9728 1301514 Bionet1_003081 CC(C)(C)NC(=O)C1Cc2ccccc2CN1C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G04 compound treatment 0.41 0.0585 2.99 0.424 0.0692 4.18 5.0713 0.9866 1179644 Bionet1_003082 COC(=O)c1ccccc1SCC(=O)c2cc(Cl)sc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G05 compound treatment 0.343 -0.00847 -0.43 0.355 2.26E-4 0.01 -0.2966 -0.6845 1909925 Bionet1_003083 O=C(NC(COC(=O)c1cccs1)c2ccccc2)c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G06 compound treatment 0.417 0.0655 3.35 0.418 0.0632 3.82 5.0683 0.9979 1909926 Bionet1_003084 Clc1cc(C(=O)/C=C/Nc2ccc(Br)cc2)c(Cl)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G07 compound treatment 0.349 -0.00247 -0.13 0.353 -0.00177 -0.11 -0.165 -0.9967 1122031 Bionet1_003085 CNC(=O)C(NS(=O)(=O)c1ccc(Br)cc1)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G08 compound treatment 0.432 0.0805 4.12 0.444 0.0892 5.39 6.7205 0.9912 1909927 Bionet1_003086 FC(F)(F)Oc1ccc(N/C=C/C(=O)c2cc(Cl)sc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G09 compound treatment 0.368 0.0165 0.85 0.367 0.0122 0.74 1.1196 0.9977 1909928 Bionet1_003087 O=C(NC(COC(=O)Nc1ccccc1)c2ccccc2)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G10 compound treatment 0.487 0.136 6.93 0.492 0.137 8.28 10.758 0.9961 1909929 Bionet1_003088 COc1ccc(N/C=C/C(=O)c2cc(Cl)sc2Cl)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G11 compound treatment 0.35 -0.00147 -0.08 0.346 -0.00877 -0.53 -0.4276 -0.7994 1495650 Bionet1_003089 CNC(=O)C(NC(=O)c1c(C)onc1c2c(F)cccc2Cl)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G12 compound treatment 0.354 0.00253 0.13 0.356 0.00123 0.07 0.1438 0.9648 1909930 Bionet1_003090 CC(=O)Oc1ccc(cc1)C(C#N)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G13 compound treatment 0.369 0.0175 0.9 0.378 0.0232 1.4 1.6253 0.9766 1909931 Bionet1_003091 [O-][N+](=O)c1ccc(/C=N/NC(=O)C(CC2CCCCC2)n3cccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G14 compound treatment 0.347 -0.00447 -0.23 0.351 -0.00377 -0.23 -0.3227 -1.0 1909932 Bionet1_003092 CS(=O)(=O)Oc1ccc(cc1)C(C#N)c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G15 compound treatment 0.397 0.0455 2.33 0.399 0.0442 2.67 3.5341 0.9977 1909933 Bionet1_003093 CNC(=O)C(Nc1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G16 compound treatment 0.36 0.00853 0.44 0.357 0.00223 0.13 0.4035 0.8839 1909934 Bionet1_003094 CS(=O)(=O)Oc1ccc(Cc2ncc(cc2Cl)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G17 compound treatment 0.344 -0.00747 -0.38 0.36 0.00523 0.32 -0.047 -0.0948 1279440 Bionet1_003095 Cc1ccc(NC(=O)N2Cc3ccccc3CC2C(=O)NC(C)(C)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G18 compound treatment 0.378 0.0265 1.36 0.394 0.0392 2.37 2.6337 0.9651 1909935 Bionet1_003096 Clc1cc(c(Cl)s1)c2ccnc(SCc3ccc(Cl)cc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G19 compound treatment 0.356 0.00453 0.23 0.361 0.00623 0.38 0.4296 0.973 1734718 Bionet1_003097 CC(C)(C)NC(=O)C1Cc2ccccc2CN1C(=O)Nc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G20 compound treatment 0.355 0.00353 0.18 0.36 0.00523 0.32 0.3507 0.9649 1909936 Bionet1_003098 FC(F)(F)c1cnc(Cc2ccc(Oc3ccc(Cl)nn3)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G21 compound treatment 0.362 0.0105 0.54 0.36 0.00523 0.32 0.6038 0.9676 1176928 Bionet1_003099 CC(C)(C)NC(=O)C1Cc2ccccc2CN1C(=O)Nc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G22 compound treatment 0.352 5.31E-4 0.03 0.349 -0.00577 -0.35 -0.2273 -0.65 1909937 Bionet1_003100 Clc1ccc(cc1)C(=O)/C=C/c2ccc(o2)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G23 positive control 0.094 -0.257 -13.16 0.091 -0.264 -15.92 -20.5687 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 G24 positive control 0.096 -0.255 -13.06 0.098 -0.257 -15.5 -20.1976 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H01 mock treatment 0.35 -0.00147 -0.08 0.36 0.00523 0.32 0.17 0.5241 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H02 mock treatment 0.358 0.00653 0.33 0.356 0.00123 0.07 0.2885 0.8433 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H03 compound treatment 0.345 -0.00647 -0.33 0.352 -0.00277 -0.17 -0.3523 -0.9503 1418682 Bionet1_003101 Cc1ccc(CSc2nc(Oc3ccc(Cl)cc3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H04 compound treatment 0.358 0.00653 0.33 0.36 0.00523 0.32 0.4592 0.9996 1909938 Bionet1_003102 COC(=O)c1ccc(N2CCN(CC2)c3ncccc3[N+](=O)[O-])c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H05 compound treatment 0.362 0.0105 0.54 0.364 0.00923 0.56 0.7746 0.9999 1363624 Bionet1_003103 Cc1ccc(CSc2nc(Oc3cccc(Cl)c3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H06 compound treatment 0.382 0.0305 1.56 0.385 0.0302 1.82 2.3941 0.997 1909939 Bionet1_003104 COC(=O)c1ccc(N2CCN(CC2)c3c(C)cccc3C)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H07 compound treatment 0.326 -0.0255 -1.3 0.32 -0.0348 -2.1 -2.4053 -0.9736 1467517 Bionet1_003105 Cc1cccc(C)c1OC(=O)CN(c2ccccc2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H08 compound treatment 0.378 0.0265 1.36 0.382 0.0272 1.64 2.1214 0.9955 1909940 Bionet1_003106 COC(=O)c1ccc(N2CCN(CC2)C(=O)c3cccs3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H09 compound treatment 0.402 0.0505 2.58 0.414 0.0592 3.58 4.3552 0.9873 1909941 Bionet1_003107 Cc1ccc(CSc2nc(Sc3ccccc3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H10 compound treatment 0.355 0.00353 0.18 0.355 2.26E-4 0.01 0.1373 0.7583 1212804 Bionet1_003108 COc1ccc(S(=O)N2CCN(Cc3ccccc3)CC2)c(OC)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H11 compound treatment 0.385 0.0335 1.71 0.391 0.0362 2.19 2.7587 0.9928 1909942 Bionet1_003109 Cc1ccc(CSc2nc(Sc3cccc(C)c3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H12 compound treatment 0.36 0.00853 0.44 0.365 0.0102 0.62 0.745 0.9855 1238261 Bionet1_003110 COc1ccc(S(=O)N2CCN(CC2)c3ccccc3F)c(OC)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H13 compound treatment 0.354 0.00253 0.13 0.365 0.0102 0.62 0.528 0.8372 1909943 Bionet1_003111 COC(=O)CSc1nc(SCc2ccc(C)cc2)nc3CCCCc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H14 compound treatment 0.359 0.00753 0.39 0.344 -0.0108 -0.65 -0.1876 -0.2482 1403051 Bionet1_003112 COc1ccc(S(=O)N2CCN(CC2)c3ccccn3)c(OC)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H15 compound treatment 0.398 0.0465 2.38 0.395 0.0402 2.43 3.3995 0.9999 1909944 Bionet1_003113 CSc1nc(Sc2ccc(Br)cc2)c3sccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H16 compound treatment 0.396 0.0445 2.28 0.395 0.0402 2.43 3.3272 0.9995 1177814 Bionet1_003114 Brc1ccc(COc2ccc3c(C#N)c4ccccn4c3c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H17 compound treatment 0.42 0.0685 3.5 0.41 0.0552 3.33 4.8352 0.9997 1909945 Bionet1_003115 Cc1ccc(CSc2nc(Sc3ccccc3N)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H18 compound treatment 0.354 0.00253 0.13 0.359 0.00423 0.26 0.2719 0.9505 1585493 Bionet1_003116 CSc1nc(Oc2ccc(F)cc2)c3cnn(c4ccccc4)c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H19 compound treatment 0.367 0.0155 0.79 0.361 0.00623 0.38 0.8273 0.9416 1728605 Bionet1_003117 CCOC(=O)c1cnc(SC)nc1Nc2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H20 compound treatment 0.356 0.00453 0.23 0.358 0.00323 0.19 0.3015 0.9963 1909946 Bionet1_003118 FC(F)(F)c1cccc(c1)C(=O)OC2CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H21 compound treatment 0.387 0.0355 1.82 0.372 0.0172 1.04 2.02 0.965 1909947 Bionet1_003119 CCOC(=O)c1cnc(SC)nc1Nc2ccc(cc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H22 compound treatment 0.359 0.00753 0.39 0.358 0.00323 0.19 0.41 0.9501 1483542 Bionet1_003120 Clc1ccc(C(=O)OC2CCS(=O)(=O)c3sccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H23 positive control 0.094 -0.257 -13.16 0.09 -0.265 -15.98 -20.6114 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 H24 positive control 0.097 -0.254 -13.01 0.101 -0.254 -15.32 -20.0334 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I01 mock treatment 0.344 -0.00747 -0.38 0.352 -0.00277 -0.17 -0.3885 -0.9316 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I02 mock treatment 0.353 0.00153 0.08 0.352 -0.00277 -0.17 -0.0631 -0.3411 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I03 compound treatment 0.353 0.00153 0.08 0.357 0.00223 0.13 0.1504 0.967 1342233 Bionet1_003121 COC(=O)C(NS(=O)(=O)c1ccc(Br)cc1)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I04 compound treatment 0.353 0.00153 0.08 0.355 2.26E-4 0.01 0.065 0.8179 1909948 Bionet1_003122 [O-][N+](=O)c1ccc(cc1)/C(=N/Nc2ccccc2)/C=C/c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I05 compound treatment 0.347 -0.00447 -0.23 0.353 -0.00177 -0.11 -0.2373 -0.9404 1909949 Bionet1_003123 FC(F)(F)c1cccc(CC(=O)OCC(=O)Nc2sccc2C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I06 compound treatment 0.373 0.0215 1.1 0.39 0.0352 2.13 2.2822 0.953 1909950 Bionet1_003124 Cc1ccccc1CSc2nccc(n2)c3cc(Cl)sc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I07 compound treatment 0.363 0.0115 0.59 0.378 0.0232 1.4 1.4084 0.9259 1909951 Bionet1_003125 FC(F)(F)c1cnc(SCC(=O)Nc2sccc2C#N)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I08 compound treatment 0.373 0.0215 1.1 0.365 0.0102 0.62 1.215 0.9626 1909952 Bionet1_003126 Cc1ccc(CSc2nccc(n2)c3cc(Cl)sc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I09 compound treatment 0.355 0.00353 0.18 0.368 0.0132 0.8 0.6922 0.8457 1711260 Bionet1_003127 COC(=O)c1ccsc1n2cc(C#N)c(=O)n(Cc3ccc(OC)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I10 compound treatment 0.35 -0.00147 -0.08 0.346 -0.00877 -0.53 -0.4276 -0.7994 1909953 Bionet1_003128 [O-][N+](=O)c1cccnc1n2ncn(c3ccc(Br)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I11 compound treatment 0.369 0.0175 0.9 0.375 0.0202 1.22 1.4972 0.9885 1909954 Bionet1_003129 Cc1ccc(c2ccc(cc2)S(=O)(=O)C)n1c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I12 compound treatment 0.354 0.00253 0.13 0.362 0.00723 0.44 0.4 0.879 1909955 Bionet1_003130 Cc1cc(C)c(Cn2ncn(c3ccc(Br)cc3)c2=O)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I13 compound treatment 0.402 0.0505 2.58 0.406 0.0512 3.09 4.0137 0.996 1909956 Bionet1_003131 COc1ccc(Oc2nc(cc(c2C#N)C(F)(F)F)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I14 compound treatment 0.346 -0.00547 -0.28 0.346 -0.00877 -0.53 -0.5723 -0.9554 1595238 Bionet1_003132 COc1cccc(Cn2ncn(c3ccc(Br)cc3)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I15 compound treatment 0.396 0.0445 2.28 0.388 0.0332 2.01 3.0284 0.998 1909957 Bionet1_003133 FC(F)(F)c1cc(nc(Sc2ccc(Cl)cc2)c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I16 compound treatment 0.382 0.0305 1.56 0.376 0.0212 1.28 2.01 0.9952 1909958 Bionet1_003134 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1n2ncn(c3ccccn3)c2=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I17 compound treatment 0.412 0.0605 3.1 0.414 0.0592 3.58 4.7167 0.9974 1909959 Bionet1_003135 FC(F)(F)c1cc(nc(Oc2ccc(Cl)cc2)c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I18 compound treatment 0.419 0.0675 3.45 0.422 0.0672 4.06 5.3113 0.9968 1909960 Bionet1_003136 Fc1ccc(N/N=C(\C=C\c2c(F)cccc2Cl)/c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I19 compound treatment 0.395 0.0435 2.23 0.393 0.0382 2.31 3.2057 0.9998 1909961 Bionet1_003137 FC(F)(F)c1cc(nc(Oc2ccc3ccccc3c2)c1C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I20 compound treatment 0.391 0.0395 2.02 0.37 0.0152 0.92 2.0792 0.9364 1448486 Bionet1_003138 COC(=O)Cc1c(sc(c1C(=O)OC)n2c(C)ccc2C)C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I21 compound treatment 0.365 0.0135 0.69 0.368 0.0132 0.8 1.0538 0.9975 1909962 Bionet1_003139 FC(F)(F)c1cc(nc(Sc2ccccc2)c1C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I22 compound treatment 0.417 0.0655 3.35 0.411 0.0562 3.39 4.7695 1.0 1909963 Bionet1_003140 Fc1ccc(cc1)N2N=C(CC2c3ccccc3)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I23 positive control 0.088 -0.263 -13.47 0.093 -0.262 -15.8 -20.7003 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 I24 positive control 0.094 -0.257 -13.16 0.099 -0.256 -15.44 -20.2273 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J01 mock treatment 0.348 -0.00347 -0.18 0.352 -0.00277 -0.17 -0.2438 -0.9996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J02 mock treatment 0.359 0.00753 0.39 0.358 0.00323 0.19 0.41 0.9501 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J03 compound treatment 0.35 -0.00147 -0.08 0.353 -0.00177 -0.11 -0.1288 -0.9849 1909964 Bionet1_003141 CCOC(=O)c1cnc(SC)nc1Nc2cc(ccc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J04 compound treatment 0.376 0.0245 1.25 0.374 0.0192 1.16 1.7076 0.9992 1909965 Bionet1_003142 CO/N=C(/CNC(=O)c1ccc(Cl)cc1Cl)\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J05 compound treatment 0.352 5.31E-4 0.03 0.361 0.00623 0.38 0.285 0.7562 1614077 Bionet1_003143 CCOC(=O)c1cnc(SC)nc1N2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J06 compound treatment 0.343 -0.00847 -0.43 0.353 -0.00177 -0.11 -0.3819 -0.8562 1620999 Bionet1_003144 Fc1ccccc1N2CCN(Cc3cc(on3)c4ccc(Cl)cc4)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J07 compound treatment 0.368 0.0165 0.85 0.372 0.0172 1.04 1.333 0.9947 1909966 Bionet1_003145 Cn1nc(c2cc(sc12)c3nnc(S)n3c4ccccc4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J08 compound treatment 0.373 0.0215 1.1 0.371 0.0162 0.98 1.4711 0.9983 1909967 Bionet1_003146 Clc1ccc(Cl)c(OCc2cc(on2)c3ccccc3Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J09 compound treatment 0.375 0.0235 1.2 0.379 0.0242 1.46 1.8849 0.9953 1909968 Bionet1_003147 CSc1nnc(c2cc3c(nn(C)c3s2)C(F)(F)F)n1c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J10 compound treatment 0.345 -0.00647 -0.33 0.349 -0.00577 -0.35 -0.4804 -0.9997 1725628 Bionet1_003148 Fc1ccccc1N2CCN(Cc3cc(on3)c4ccccc4Cl)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J11 compound treatment 0.353 0.00153 0.08 0.369 0.0142 0.86 0.6626 0.7684 1909969 Bionet1_003149 Cc1ccc(cc1)c2nnc(o2)c3cc4c(nn(C)c4s3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J12 compound treatment 0.386 0.0345 1.77 0.386 0.0312 1.89 2.5814 0.9995 1909970 Bionet1_003150 [O-][N+](=O)c1cc(/C=N\OC(=O)c2c(F)cccc2F)ccc1N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J13 compound treatment 0.34 -0.0115 -0.59 0.37 0.0152 0.92 0.2353 0.2158 1909971 Bionet1_003151 COc1cccc(c1)c2nnc(o2)c3cc4c(nn(C)c4s3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J14 compound treatment 0.396 0.0445 2.28 0.374 0.0192 1.16 2.4308 0.9511 1909972 Bionet1_003152 Cc1ccc(cc1)C(=O)O/N=C\c2ccc(N3CCCCC3)c(c2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J15 compound treatment 0.37 0.0185 0.95 0.372 0.0172 1.04 1.4053 0.9989 1909973 Bionet1_003153 Cn1nc(c2cc(sc12)c3nnc(SCC=C)n3C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J16 compound treatment 0.363 0.0115 0.59 0.364 0.00923 0.56 0.8107 0.9996 1909974 Bionet1_003154 [O-][N+](=O)c1cc(/C=N\OC(=O)c2cccc(Cl)c2)ccc1N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J17 compound treatment 0.38 0.0285 1.46 0.368 0.0132 0.8 1.5961 0.9598 1909975 Bionet1_003155 Cn1nc(c2cc(sc12)c3nnc(SCC#C)n3C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J18 compound treatment 0.362 0.0105 0.54 0.359 0.00423 0.26 0.5612 0.9418 1909976 Bionet1_003156 [O-][N+](=O)c1cc(/C=N/OC(=O)c2cccs2)ccc1N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J19 compound treatment 0.385 0.0335 1.71 0.384 0.0292 1.76 2.4599 0.9999 1909977 Bionet1_003157 CCCCSc1nnc(c2cc3c(nn(C)c3s2)C(F)(F)F)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J20 compound treatment 0.358 0.00653 0.33 0.361 0.00623 0.38 0.5019 0.9983 1909978 Bionet1_003158 FC(F)(F)c1cccc(OCc2cc(on2)c3ccc(Cl)c(Cl)c3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J21 compound treatment 0.362 0.0105 0.54 0.357 0.00223 0.13 0.4758 0.8573 1742697 Bionet1_003159 Clc1ccc(cc1)C(=O)Nc2ccc(oc2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J22 compound treatment 0.365 0.0135 0.69 0.362 0.00723 0.44 0.7977 0.9753 1644727 Bionet1_003160 COC(=O)c1sccc1OCc2cc(on2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J23 positive control 0.088 -0.263 -13.47 0.098 -0.257 -15.5 -20.4869 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 J24 positive control 0.098 -0.253 -12.96 0.107 -0.248 -14.96 -19.7411 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K01 mock treatment 0.345 -0.00647 -0.33 0.352 -0.00277 -0.17 -0.3523 -0.9503 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K02 mock treatment 0.352 5.31E-4 0.03 0.351 -0.00377 -0.23 -0.1419 -0.6184 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K03 compound treatment 0.348 -0.00347 -0.18 0.347 -0.00777 -0.47 -0.4573 -0.9114 1565675 Bionet1_003161 COC(=O)c1cc(C#N)c(NCc2cc(no2)c3ccc(Cl)cc3)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K04 compound treatment 0.379 0.0275 1.41 0.377 0.0222 1.34 1.9442 0.9997 1909979 Bionet1_003162 COc1cccc(c1)C2=NN(C(C2)c3ccc(Cl)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K05 compound treatment 0.353 0.00153 0.08 0.359 0.00423 0.26 0.2358 0.8835 1909980 Bionet1_003163 COc1ccc(cc1)c2cc(CNc3nc(C)c(cc3C#N)C(=O)C)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K06 compound treatment 0.393 0.0415 2.12 0.395 0.0402 2.43 3.2187 0.9978 1909981 Bionet1_003164 Clc1ccc(cc1)N2N=C(CC2c3ccccc3)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K07 compound treatment 0.363 0.0115 0.59 0.365 0.0102 0.62 0.8534 0.9997 1535204 Bionet1_003165 Cc1ccc(c2ccc(cc2)S(=O)(=O)C)n1c3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K08 compound treatment 0.348 -0.00347 -0.18 0.345 -0.00977 -0.59 -0.5426 -0.8807 1408999 Bionet1_003166 COc1ccc(cc1)n2ccc(=O)c(Cc3c(Cl)cccc3Cl)c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K09 compound treatment 0.375 0.0235 1.2 0.378 0.0232 1.4 1.8422 0.9971 1909982 Bionet1_003167 Fc1ccc(cc1)C(=O)Nc2ccc(/C=C/c3nc4ccccc4o3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K10 compound treatment 0.394 0.0425 2.17 0.395 0.0402 2.43 3.2549 0.9985 1909983 Bionet1_003168 [O-][N+](=O)c1cccc(c1)N2N=C(CC2c3ccccc3)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K11 compound treatment 0.379 0.0275 1.41 0.373 0.0182 1.1 1.7734 0.9926 1909984 Bionet1_003169 FC(F)(F)c1cc(nc(N2CCOCC2)c1C#N)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K12 compound treatment 0.364 0.0125 0.64 0.37 0.0152 0.92 1.103 0.9844 1211145 Bionet1_003170 Clc1ccc(cc1)C2CN(CC2C(=O)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K13 compound treatment 0.366 0.0145 0.74 0.37 0.0152 0.92 1.1753 0.9944 1909985 Bionet1_003171 CCN(CC)c1nc(cc(c1C#N)C(F)(F)F)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K14 compound treatment 0.379 0.0275 1.41 0.383 0.0282 1.7 2.2003 0.9955 1712611 Bionet1_003172 Fc1ccccc1C2CN(CC2C(=O)c3ccc(Cl)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K15 compound treatment 0.355 0.00353 0.18 0.354 -7.74E-4 -0.05 0.0946 0.5074 1909986 Bionet1_003173 COc1ccc(cc1)c2cc(CNC(=O)CN(C)Cc3ccccc3)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K16 compound treatment 0.402 0.0505 2.58 0.395 0.0402 2.43 3.5441 0.9995 1617843 Bionet1_003174 COc1cccc(c1)C(=O)C2CN(CC2c3ccc(Cl)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K17 compound treatment 0.402 0.0505 2.58 0.386 0.0312 1.89 3.1599 0.988 1909987 Bionet1_003175 FC(F)(F)c1cc(nc(Sc2ccccc2)c1C#N)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K18 compound treatment 0.374 0.0225 1.15 0.392 0.0372 2.25 2.4037 0.9518 1223140 Bionet1_003176 COc1cc(NC(=S)NCc2cccc(Cl)c2)c(C#N)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K19 compound treatment 0.409 0.0575 2.94 0.413 0.0582 3.51 4.5656 0.9961 1909988 Bionet1_003177 Cc1ccc(Sc2nc(nnc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K20 compound treatment 0.379 0.0275 1.41 0.377 0.0222 1.34 1.9442 0.9997 1521688 Bionet1_003178 Cc1c(Cc2c(Cl)cccc2Cl)c(=O)ccn1c3ccc(cc3)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K21 compound treatment 0.368 0.0165 0.85 0.368 0.0132 0.8 1.1623 0.9996 1909989 Bionet1_003179 Clc1ccc(Oc2nc(nnc2c3ccccc3)c4ccccc4)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K22 compound treatment 0.366 0.0145 0.74 0.364 0.00923 0.56 0.9192 0.9899 1130619 Bionet1_003180 CN(C)c1ccc(cc1)n2ccc(=O)c(Cc3c(Cl)cccc3Cl)c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K23 positive control 0.09 -0.261 -13.37 0.095 -0.26 -15.68 -20.5426 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 K24 positive control 0.095 -0.256 -13.11 0.105 -0.25 -15.08 -19.935 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L01 mock treatment 0.351 -4.69E-4 -0.02 0.358 0.00323 0.19 0.1208 0.6154 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L02 mock treatment 0.357 0.00553 0.28 0.354 -7.74E-4 -0.05 0.1669 0.5824 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L03 compound treatment 0.359 0.00753 0.39 0.361 0.00623 0.38 0.5381 0.9999 1389763 Bionet1_003181 COCc1cc(nc(SCc2ccc(Cl)cc2)n1)N3CCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L04 compound treatment 0.359 0.00753 0.39 0.357 0.00223 0.13 0.3673 0.9006 1909990 Bionet1_003182 [O-][N+](=O)c1cc(/C=N\OC(=O)c2ccc(F)cc2)ccc1N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L05 compound treatment 0.332 -0.0195 -1.0 0.36 0.00523 0.32 -0.4808 -0.4605 1909991 Bionet1_003183 Cc1ccc(cc1)c2nnc(o2)c3c(Cl)n(C)nc3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L06 compound treatment 0.353 0.00153 0.08 0.362 0.00723 0.44 0.3638 0.8209 1909992 Bionet1_003184 Cc1ccc(cc1)C(=O)O/N=C\c2ccc(N3CCOCC3)c(c2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L07 compound treatment 0.356 0.00453 0.23 0.362 0.00723 0.44 0.4723 0.9562 1909993 Bionet1_003185 Cn1nc(c(c1Cl)c2nnc(o2)c3ccc(Cl)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L08 compound treatment 0.382 0.0305 1.56 0.387 0.0322 1.95 2.4795 0.994 1909994 Bionet1_003186 [O-][N+](=O)c1cc(/C=N\OC(=O)c2ccccc2Cl)ccc1N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L09 compound treatment 0.412 0.0605 3.1 0.371 0.0162 0.98 2.8812 0.8875 1909995 Bionet1_003187 COc1ccc(cc1)C(=O)OCc2cc(on2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L10 compound treatment 0.353 0.00153 0.08 0.358 0.00323 0.19 0.1931 0.9198 1909996 Bionet1_003188 Clc1ccc(cc1)c2ccnc(Sc3cc(Cl)ccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L11 compound treatment 0.373 0.0215 1.1 0.364 0.00923 0.56 1.1723 0.9502 1172634 Bionet1_003189 Clc1ccc(cc1)c2cc(COC(=O)c3ccc(Cl)cc3Cl)no2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L12 compound treatment 0.357 0.00553 0.28 0.36 0.00523 0.32 0.4231 0.9985 1909997 Bionet1_003190 Clc1ccc(cc1)c2ccnc(Oc3cc(Cl)cc(Cl)c3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L13 compound treatment 0.366 0.0145 0.74 0.362 0.00723 0.44 0.8338 0.9678 1909998 Bionet1_003191 FC(F)(F)c1cccc(c1)C(=O)OCc2cc(on2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L14 compound treatment 0.392 0.0405 2.07 0.387 0.0322 1.95 2.8411 0.9995 1909999 Bionet1_003192 Clc1ccc(cc1)c2ccnc(Oc3cc(Cl)ccc3Cl)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L15 compound treatment 0.372 0.0205 1.05 0.371 0.0162 0.98 1.435 0.9994 1910000 Bionet1_003193 Fc1cccc(F)c1C(=O)OCc2cc(on2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L16 compound treatment 0.361 0.00953 0.49 0.35 -0.00477 -0.29 0.1408 0.2487 1910001 Bionet1_003194 COc1cccc(Sc2nc(ncc2S(=O)(=O)C)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L17 compound treatment 0.365 0.0135 0.69 0.364 0.00923 0.56 0.8831 0.9942 1910002 Bionet1_003195 Clc1ccc(cc1Cl)c2cc(COC(=O)c3cccs3)no2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L18 compound treatment 0.365 0.0135 0.69 0.368 0.0132 0.8 1.0538 0.9975 1910003 Bionet1_003196 CS(=O)(=O)c1cnc(nc1Oc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L19 compound treatment 0.359 0.00753 0.39 0.36 0.00523 0.32 0.4954 0.9951 1552964 Bionet1_003197 CS(=O)(=O)N(CC(=O)N1CCCCC1)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L20 compound treatment 0.357 0.00553 0.28 0.365 0.0102 0.62 0.6365 0.9374 1910004 Bionet1_003198 CS(=O)(=O)c1cnc(nc1Sc2ccc(F)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L21 compound treatment 0.366 0.0145 0.74 0.36 0.00523 0.32 0.7485 0.9272 1661730 Bionet1_003199 COc1cc(N(CC(=O)N2CCOCC2)S(=O)(=O)C)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L22 compound treatment 0.363 0.0115 0.59 0.366 0.0112 0.68 0.8961 0.9976 1910005 Bionet1_003200 Cc1ccc(Sc2nc(ncc2S(=O)(=O)C)c3ccccc3)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L23 positive control 0.093 -0.258 -13.22 0.093 -0.262 -15.8 -20.5195 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 L24 positive control 0.095 -0.256 -13.11 0.1 -0.255 -15.38 -20.1484 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M01 mock treatment 0.355 0.00353 0.18 0.358 0.00323 0.19 0.2654 0.9993 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M02 mock treatment 0.358 0.00653 0.33 0.359 0.00423 0.26 0.4165 0.9912 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M03 compound treatment 0.353 0.00153 0.08 0.352 -0.00277 -0.17 -0.0631 -0.3411 1910006 Bionet1_003201 Fc1ccc(Sc2nc(nnc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M04 compound treatment 0.366 0.0145 0.74 0.362 0.00723 0.44 0.8338 0.9678 1421809 Bionet1_003202 COc1ccc(Cn2ccc(=O)c(Cc3c(Cl)cccc3Cl)c2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M05 compound treatment 0.339 -0.0125 -0.64 0.367 0.0122 0.74 0.0711 0.0729 1910007 Bionet1_003203 N#Cc1ccc(Oc2nc(nnc2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M06 compound treatment 0.356 0.00453 0.23 0.36 0.00523 0.32 0.3869 0.9885 1269073 Bionet1_003204 Cc1c(Cc2c(Cl)cccc2Cl)c(=O)ccn1Cc3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M07 compound treatment 0.352 5.31E-4 0.03 0.363 0.00823 0.5 0.3703 0.7447 1910008 Bionet1_003205 FC(F)(F)c1cccc(Oc2nc(nnc2c3ccccc3)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M08 compound treatment 0.364 0.0125 0.64 0.368 0.0132 0.8 1.0176 0.9941 1910009 Bionet1_003206 CCOC(=O)c1c2ccc(OCc3ccc(cc3)[N+](=O)[O-])cc2n4ccccc14 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M09 compound treatment 0.375 0.0235 1.2 0.369 0.0142 0.86 1.4581 0.9863 1910010 Bionet1_003207 [O-][N+](=O)c1ccc(CSc2ccsc2C(=O)Nc3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M10 compound treatment 0.4 0.0485 2.48 0.401 0.0462 2.79 3.7279 0.9983 1308969 Bionet1_003208 CCOC(=O)c1c2ccc(OCc3ccc(F)cc3)cc2n4ccccc14 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M11 compound treatment 0.353 0.00153 0.08 0.358 0.00323 0.19 0.1931 0.9198 1910011 Bionet1_003209 Cc1nn(c(N)c1c2cccc(c2)C(F)(F)F)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M12 compound treatment 0.357 0.00553 0.28 0.367 0.0122 0.74 0.7219 0.9133 1375905 Bionet1_003210 Cc1c(Cc2c(Cl)cccc2Cl)c(=O)ccn1Cc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M13 compound treatment 0.349 -0.00247 -0.13 0.355 2.26E-4 0.01 -0.0796 -0.6271 1910012 Bionet1_003211 Clc1ccc(Cn2cccc(c3nnc(SCC=C)o3)c2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M14 compound treatment 0.359 0.00753 0.39 0.351 -0.00377 -0.23 0.1112 0.2485 1401614 Bionet1_003212 Cc1c(Cc2c(Cl)cccc2Cl)c(=O)ccn1Cc3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M15 compound treatment 0.363 0.0115 0.59 0.363 0.00823 0.5 0.7681 0.9964 1175142 Bionet1_003213 OC(CN1CCN(CC1)c2ccccc2F)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M16 compound treatment 0.357 0.00553 0.28 0.36 0.00523 0.32 0.4231 0.9985 1736523 Bionet1_003214 Cc1ccc(Cn2ccc(=O)c(Cc3c(Cl)cccc3Cl)c2C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M17 compound treatment 0.357 0.00553 0.28 0.355 2.26E-4 0.01 0.2096 0.7403 1910013 Bionet1_003215 OC(CN1CCN(CC1)c2cccc(Cl)c2)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M18 compound treatment 0.362 0.0105 0.54 0.363 0.00823 0.5 0.7319 0.9992 1631313 Bionet1_003216 Cc1c(Cc2c(Cl)cccc2Cl)c(=O)ccn1CCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M19 compound treatment 0.37 0.0185 0.95 0.365 0.0102 0.62 1.1065 0.9785 1910014 Bionet1_003217 Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M20 compound treatment 0.357 0.00553 0.28 0.363 0.00823 0.5 0.5511 0.9644 1219302 Bionet1_003218 Cc1c(Cc2c(Cl)cccc2Cl)c(=O)ccn1Cc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M21 compound treatment 0.368 0.0165 0.85 0.363 0.00823 0.5 0.9488 0.9679 1910015 Bionet1_003219 Fc1ccc(cc1)N2CCN(CC3CN4C(=N3)c5ccccc5NC4=O)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M22 compound treatment 0.367 0.0155 0.79 0.368 0.0132 0.8 1.1261 1.0 1660617 Bionet1_003220 CC(c1ccccc1)n2ccc(=O)c(Cc3c(Cl)cccc3Cl)c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M23 positive control 0.093 -0.258 -13.22 0.092 -0.263 -15.86 -20.5622 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 M24 positive control 0.099 -0.252 -12.91 0.098 -0.257 -15.5 -20.0892 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N01 mock treatment 0.352 5.31E-4 0.03 0.355 2.26E-4 0.01 0.0288 0.9491 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N02 mock treatment 0.35 -0.00147 -0.08 0.358 0.00323 0.19 0.0846 0.4053 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N03 compound treatment 0.349 -0.00247 -0.13 0.353 -0.00177 -0.11 -0.165 -0.9967 1910016 Bionet1_003221 Cc1nc(nc2CCCc21)S(=O)(=O)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N04 compound treatment 0.35 -0.00147 -0.08 0.35 -0.00477 -0.29 -0.2569 -0.8626 1910017 Bionet1_003222 CSc1nc(Oc2ccc3ccccc3c2)c4cnn(c5ccccc5)c4n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N05 compound treatment 0.347 -0.00447 -0.23 0.348 -0.00677 -0.41 -0.4507 -0.9622 1910018 Bionet1_003223 Clc1ccc(C(=O)OCc2cc(on2)c3ccccc3Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N06 compound treatment 0.38 0.0285 1.46 0.371 0.0162 0.98 1.7242 0.9812 1910019 Bionet1_003224 COc1ccc(CSc2ncc3CSc4ccc(C)cc4-c3n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N07 compound treatment 0.35 -0.00147 -0.08 0.345 -0.00977 -0.59 -0.4703 -0.7907 1910020 Bionet1_003225 FC(F)(F)c1cccc(c1)C(=O)OCc2cc(on2)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N08 compound treatment 0.395 0.0435 2.23 0.398 0.0432 2.61 3.4191 0.9969 1910021 Bionet1_003226 Cc1ccc2SCc3cnc(SCc4cccc(c4)[N+](=O)[O-])nc3-c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N09 compound treatment 0.401 0.0495 2.53 0.389 0.0342 2.07 3.2518 0.9949 1910022 Bionet1_003227 Clc1ccc(NC(=O)OCc2cc(on2)c3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N10 compound treatment 0.373 0.0215 1.1 0.371 0.0162 0.98 1.4711 0.9983 1910023 Bionet1_003228 Cc1ccc2SCc3cnc(SCc4ccc(cc4)C(C)(C)C)nc3-c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N11 compound treatment 0.363 0.0115 0.59 0.372 0.0172 1.04 1.1522 0.9639 1910024 Bionet1_003229 Clc1ccc(NC(=O)OCc2cc(on2)c3ccccc3Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N12 compound treatment 0.363 0.0115 0.59 0.371 0.0162 0.98 1.1096 0.9705 1910025 Bionet1_003230 Cc1cccc(CSc2ncc3CSc4ccc(C)cc4-c3n2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N13 compound treatment 0.378 0.0265 1.36 0.374 0.0192 1.16 1.78 0.997 1910026 Bionet1_003231 Fc1ccc(cc1)C(=O)OCc2cc(on2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N14 compound treatment 0.377 0.0255 1.31 0.378 0.0232 1.4 1.9145 0.9994 1910027 Bionet1_003232 Cc1ccc2SCc3cnc(SCc4ccc(Cl)cc4)nc3-c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N15 compound treatment 0.38 0.0285 1.46 0.379 0.0242 1.46 2.0657 1.0 1910028 Bionet1_003233 Cc1ccc(NC(=O)OCc2cc(on2)c3ccc(Cl)c(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N16 compound treatment 0.359 0.00753 0.39 0.353 -0.00177 -0.11 0.1966 0.4918 1910029 Bionet1_003234 CSc1nc(Sc2ccc(C)cc2)c3cnn(c4ccccc4)c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N17 compound treatment 0.366 0.0145 0.74 0.369 0.0142 0.86 1.1326 0.9974 1910030 Bionet1_003235 Clc1ccc(NC(=O)OCc2cc(on2)c3ccc(Cl)c(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N18 compound treatment 0.353 0.00153 0.08 0.355 2.26E-4 0.01 0.065 0.8179 1910031 Bionet1_003236 CSc1nc(Sc2ccc(F)cc2)c3cnn(c4ccccc4)c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N19 compound treatment 0.372 0.0205 1.05 0.371 0.0162 0.98 1.435 0.9994 1910032 Bionet1_003237 Clc1ccc(NC(=O)OCc2cc(on2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N20 compound treatment 0.357 0.00553 0.28 0.355 2.26E-4 0.01 0.2096 0.7403 1910033 Bionet1_003238 CSc1nc(Sc2ccccc2)c3cnn(c4ccccc4)c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N21 compound treatment 0.356 0.00453 0.23 0.358 0.00323 0.19 0.3015 0.9963 1238924 Bionet1_003239 Cc1cccc(C)c1OC(=O)CN(c2ccc(Cl)cc2)S(=O)(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N22 compound treatment 0.354 0.00253 0.13 0.35 -0.00477 -0.29 -0.1123 -0.3554 1910034 Bionet1_003240 CSc1nc(Sc2cccc(Cl)c2)c3cnn(c4ccccc4)c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N23 positive control 0.09 -0.261 -13.37 0.092 -0.263 -15.86 -20.6707 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 N24 positive control 0.097 -0.254 -13.01 0.096 -0.259 -15.62 -20.2468 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O01 mock treatment 0.358 0.00653 0.33 0.363 0.00823 0.5 0.5873 0.9814 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O02 mock treatment 0.36 0.00853 0.44 0.362 0.00723 0.44 0.6169 1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O03 compound treatment 0.356 0.00453 0.23 0.359 0.00423 0.26 0.3442 0.9988 1910035 Bionet1_003241 Fc1ccccc1N2CCN(CC3CN4C(=N3)c5ccccc5NC4=O)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O04 compound treatment 0.387 0.0355 1.82 0.399 0.0442 2.67 3.1725 0.9824 1910036 Bionet1_003242 Clc1ccc(CNS(=O)(=O)/C=C/c2ccc(Br)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O05 compound treatment 0.351 -4.69E-4 -0.02 0.361 0.00623 0.38 0.2488 0.6607 1910037 Bionet1_003243 O=C1Nc2ccccc2C3=NC(CN4CCN(Cc5ccccc5)CC4)CN31 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O06 compound treatment 0.345 -0.00647 -0.33 0.356 0.00123 0.07 -0.1816 -0.5357 1910038 Bionet1_003244 [O-][N+](=O)c1ccc(/C=C/S(=O)(=O)NCc2ccc(Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O07 compound treatment 0.376 0.0245 1.25 0.368 0.0132 0.8 1.4515 0.9762 1218222 Bionet1_003245 Brc1ccc(CN2c3ccccc3Sc4cccnc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O08 compound treatment 0.364 0.0125 0.64 0.365 0.0102 0.62 0.8896 0.9998 1910039 Bionet1_003246 Ic1ccc(cc1)S(=O)(=O)NCc2cccs2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O09 compound treatment 0.365 0.0135 0.69 0.365 0.0102 0.62 0.9257 0.9984 1910040 Bionet1_003247 CNc1nc(nc(c1C#N)c2cccc(c2)C(F)(F)F)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O10 compound treatment 0.357 0.00553 0.28 0.365 0.0102 0.62 0.6365 0.9374 1910041 Bionet1_003248 Clc1ccc(CNS(=O)(=O)/C=C/c2ccc3OCOc3c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O11 compound treatment 0.353 0.00153 0.08 0.358 0.00323 0.19 0.1931 0.9198 1910042 Bionet1_003249 Cn1nc(c(/C=N/OC(=O)CCl)c1Sc2ccccc2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O12 compound treatment 0.36 0.00853 0.44 0.357 0.00223 0.13 0.4035 0.8839 1574751 Bionet1_003250 Ic1ccc(cc1)S(=O)(=O)NCc2cccnc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O13 compound treatment 0.36 0.00853 0.44 0.351 -0.00377 -0.23 0.1473 0.2994 1732198 Bionet1_003251 CC1CN(CC(C)O1)C(=O)c2cccn(Cc3c(Cl)cccc3Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O14 compound treatment 0.401 0.0495 2.53 0.397 0.0422 2.55 3.5933 1.0 1910043 Bionet1_003252 Clc1ccc(cc1)c2ccc(/C=C/S(=O)(=O)NCc3cccs3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O15 compound treatment 0.358 0.00653 0.33 0.363 0.00823 0.5 0.5873 0.9814 1727413 Bionet1_003253 Clc1ccc(cc1)c2nn(c3ccc(Cl)cc3)c(=O)c4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O16 compound treatment 0.371 0.0195 1.0 0.374 0.0192 1.16 1.5269 0.9972 1611664 Bionet1_003254 Ic1ccc(cc1)C(=O)NC2CCCCCCC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O17 compound treatment 0.359 0.00753 0.39 0.359 0.00423 0.26 0.4527 0.98 1910044 Bionet1_003255 Fc1ccc(cc1)c2nn(c3ccc(OC(F)(F)F)cc3)c(=O)c4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O18 compound treatment 0.358 0.00653 0.33 0.362 0.00723 0.44 0.5446 0.9913 1910045 Bionet1_003256 CN(N(S(=O)(=O)C)S(=O)(=O)C)c1c(C#N)c(nn1C)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O19 compound treatment 0.367 0.0155 0.79 0.364 0.00923 0.56 0.9554 0.9849 1910046 Bionet1_003257 Fc1ccc(cc1)c2nn(c3ccc(cc3)C(F)(F)F)c(=O)c4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O20 compound treatment 0.357 0.00553 0.28 0.363 0.00823 0.5 0.5511 0.9644 1910047 Bionet1_003258 CN(N1C(=O)c2ccncc2C1=O)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O21 compound treatment 0.357 0.00553 0.28 0.365 0.0102 0.62 0.6365 0.9374 1910048 Bionet1_003259 Cc1nn(c2c(Cl)cc(cc2Cl)C(F)(F)F)c(=O)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O22 compound treatment 0.392 0.0405 2.07 0.393 0.0382 2.31 3.0972 0.9986 1910049 Bionet1_003260 FC(F)(F)c1cccc(N/C=C/C(=O)c2ccc(Oc3ncccn3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O23 positive control 0.09 -0.261 -13.37 0.094 -0.261 -15.74 -20.5853 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 O24 positive control 0.095 -0.256 -13.11 0.098 -0.257 -15.5 -20.2338 -0.9965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P01 mock treatment 0.36 0.00853 0.44 0.365 0.0102 0.62 0.745 0.9855 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P02 mock treatment 0.358 0.00653 0.33 0.363 0.00823 0.5 0.5873 0.9814 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P03 compound treatment 0.361 0.00953 0.49 0.354 -7.74E-4 -0.05 0.3116 0.6364 1259992 Bionet1_003261 CS(=O)(=O)N(CC(=O)Oc1ccc2ccccc2c1)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P04 compound treatment 0.354 0.00253 0.13 0.356 0.00123 0.07 0.1438 0.9648 1910050 Bionet1_003262 CSc1nc(Sc2ccccc2Cl)c3cnn(c4ccccc4)c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P05 compound treatment 0.352 5.31E-4 0.03 0.355 2.26E-4 0.01 0.0288 0.9491 1910051 Bionet1_003263 CCOC(=O)c1cnc(SC)nc1Sc2cc(Cl)ccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P06 compound treatment 0.346 -0.00547 -0.28 0.357 0.00223 0.13 -0.1027 -0.3311 1910052 Bionet1_003264 Oc1nc(SCc2ccccc2)ncc1S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P07 compound treatment 0.365 0.0135 0.69 0.358 0.00323 0.19 0.6269 0.8722 1910053 Bionet1_003265 CCOC(=O)c1cnc(SC)nc1Sc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P08 compound treatment 0.348 -0.00347 -0.18 0.354 -7.74E-4 -0.05 -0.1585 -0.8639 1910054 Bionet1_003266 Clc1ccc(cc1)C2=NC(N=C(S2)c3ccc(Cl)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P09 compound treatment 0.354 0.00253 0.13 0.366 0.0112 0.68 0.5707 0.8272 1910055 Bionet1_003267 CCOC(=O)c1cnc(SC)nc1Sc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P10 compound treatment 0.34 -0.0115 -0.59 0.351 -0.00377 -0.23 -0.5758 -0.9152 1254221 Bionet1_003268 Cc1ccc(cc1)c2nn(c3nc(nc(N)c23)c4ccc(C)cc4)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P11 compound treatment 0.343 -0.00847 -0.43 0.353 -0.00177 -0.11 -0.3819 -0.8562 1910056 Bionet1_003269 CCOC(=O)c1cnc(SC)nc1Sc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P12 compound treatment 0.354 0.00253 0.13 0.357 0.00223 0.13 0.1865 0.9998 1556945 Bionet1_003270 Cc1ccc(cc1)C(=O)Nc2ncnc3n(nc(c4ccc(C)cc4)c23)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P13 compound treatment 0.37 0.0185 0.95 0.361 0.00623 0.38 0.9358 0.918 1532052 Bionet1_003271 COc1ccc(CN2CCn3ncc(C(=O)Nc4ccccc4)c3C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P14 compound treatment 0.362 0.0105 0.54 0.372 0.0172 1.04 1.1161 0.9531 1371341 Bionet1_003272 CC(=O)N(C(=O)C)c1ncnc2n(nc(c3ccc(Cl)cc3)c12)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P15 compound treatment 0.375 0.0235 1.2 0.382 0.0272 1.64 2.013 0.9882 1170723 Bionet1_003273 COc1ccc(CN2CCn3ncc(C(=O)Nc4cccc(C)c4)c3C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P16 compound treatment 0.359 0.00753 0.39 0.363 0.00823 0.5 0.6234 0.9921 1713837 Bionet1_003274 CCS(=O)(=O)c1ccc(C(=O)Nc2nccs2)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P17 compound treatment 0.364 0.0125 0.64 0.365 0.0102 0.62 0.8896 0.9998 1910057 Bionet1_003275 COC(=O)c1nn(c(Cl)c1/C=N/OCc2ccc(F)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P18 compound treatment 0.361 0.00953 0.49 0.351 -0.00377 -0.23 0.1835 0.3411 1910058 Bionet1_003276 CCOC(=O)/C=C\1/C(=O)N(Cc2ccc(Cl)c(Cl)c2)c3ccccc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P19 compound treatment 0.356 0.00453 0.23 0.346 -0.00877 -0.53 -0.2107 -0.3645 1910059 Bionet1_003277 Cc1cccc2c(cc(Sc3ccc(Cl)cc3)nc12)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P20 compound treatment 0.355 0.00353 0.18 0.358 0.00323 0.19 0.2654 0.9993 1910060 Bionet1_003278 Cn1nc(c2cc(sc12)C(=O)Nc3ccc(F)cc3F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P21 compound treatment 0.353 0.00153 0.08 0.371 0.0162 0.98 0.748 0.7612 1910061 Bionet1_003279 Cc1cccc2c(cc(Oc3cccc(c3)C(F)(F)F)nc12)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P22 compound treatment 0.349 -0.00247 -0.13 0.381 0.0262 1.58 1.0302 0.6487 1910062 Bionet1_003280 COc1ccc(NC(=O)c2cc3c(nn(C)c3s2)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P23 positive control 0.09 -0.261 -13.37 0.092 -0.263 -15.86 -20.6707 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.577 P24 positive control 0.097 -0.254 -13.01 0.097 -0.258 -15.56 -20.2042 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A01 mock treatment 0.315 -0.0364 -1.86 0.322 -0.0284 -1.71 -2.528 -0.9991 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A02 mock treatment 0.314 -0.0374 -1.91 0.323 -0.0274 -1.65 -2.5215 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A03 compound treatment 0.315 -0.0364 -1.86 0.322 -0.0284 -1.71 -2.528 -0.9991 1143038 Bionet1_003281 Clc1ccc(CN2COc3c(C2)cc(Cl)c4cccnc34)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A04 compound treatment 0.312 -0.0394 -2.02 0.321 -0.0294 -1.77 -2.6792 -0.998 1910063 Bionet1_003282 Clc1ccc(CN2C(=O)CCSc3ccc(Cl)cc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A05 compound treatment 0.315 -0.0364 -1.86 0.321 -0.0294 -1.77 -2.5707 -0.9997 1268704 Bionet1_003283 Clc1ccc(cc1)c2nc3ccccc3cc2Oc4ccccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A06 compound treatment 0.338 -0.0134 -0.69 0.34 -0.0104 -0.63 -0.9281 -0.999 1910064 Bionet1_003284 CN1c2ccsc2/C(=N/NC(=O)c3ccc(F)cc3)/CS1(=O)=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A07 compound treatment 0.322 -0.0294 -1.5 0.321 -0.0294 -1.77 -2.3176 -0.9966 1312774 Bionet1_003285 Cc1ccc(Oc2nc(SCc3ccc(Cl)cc3)nc4CCCCc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A08 compound treatment 0.32 -0.0314 -1.61 0.316 -0.0344 -2.08 -2.6034 -0.992 1910065 Bionet1_003286 Clc1ccc2SCCC(=O)N(Cc3c(Cl)cccc3Cl)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A09 compound treatment 0.318 -0.0334 -1.71 0.319 -0.0314 -1.89 -2.5476 -0.9987 1910066 Bionet1_003287 CC(C)(C)Sc1nc(SCc2ccc(Cl)cc2)nc3CCCCc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A10 compound treatment 0.321 -0.0304 -1.56 0.32 -0.0304 -1.83 -2.3965 -0.9966 1910067 Bionet1_003288 Fc1cccc(Cl)c1CN2C(=O)CCSc3ccc(Cl)cc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A11 compound treatment 0.318 -0.0334 -1.71 0.317 -0.0334 -2.01 -2.633 -0.9966 1910068 Bionet1_003289 COC(=O)CSc1nc(SCc2ccccc2Cl)nc3CCCCc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A12 compound treatment 0.331 -0.0204 -1.04 0.325 -0.0254 -1.53 -1.8215 -0.9825 1332871 Bionet1_003290 COc1ccc(cc1)C(=O)CN2C(=O)CCSc3ccc(Cl)cc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A13 compound treatment 0.326 -0.0254 -1.3 0.324 -0.0264 -1.59 -2.0449 -0.9949 1277880 Bionet1_003291 CN(C)c1ncc(c(n1)N2CCCC2)S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A14 compound treatment 0.32 -0.0314 -1.61 0.328 -0.0224 -1.35 -2.0911 -0.9963 1143218 Bionet1_003292 CN1c2ccsc2C(=C(C(=O)Nc3ccc(Cl)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A15 compound treatment 0.323 -0.0284 -1.45 0.328 -0.0224 -1.35 -1.9826 -0.9993 1564557 Bionet1_003293 O=S(=O)(c1ccccc1)c2cnc(nc2N3CCCCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A16 compound treatment 0.325 -0.0264 -1.35 0.326 -0.0244 -1.47 -1.9957 -0.9991 1185545 Bionet1_003294 CN1c2ccsc2C(=C(C(=O)Nc3ccc(C)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A17 compound treatment 0.323 -0.0284 -1.45 0.325 -0.0254 -1.53 -2.1107 -0.9997 1584305 Bionet1_003295 CCN(CC)c1nc(ncc1S(=O)(=O)c2ccc(Cl)cc2)N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A18 compound treatment 0.32 -0.0314 -1.61 0.324 -0.0264 -1.59 -2.2619 -1.0 1683941 Bionet1_003296 CN1c2ccsc2C(=C(C(=O)Nc3c(C)cccc3C)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A19 compound treatment 0.327 -0.0244 -1.25 0.321 -0.0294 -1.77 -2.1368 -0.9853 1910069 Bionet1_003297 Clc1ncc(CO/N=C/CC(=O)c2ccc(Br)cc2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A20 compound treatment 0.318 -0.0334 -1.71 0.323 -0.0274 -1.65 -2.3769 -0.9999 1456773 Bionet1_003298 CN1c2ccsc2C(=C(C(=O)Nc3ccc(F)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A21 compound treatment 0.32 -0.0314 -1.61 0.322 -0.0284 -1.71 -2.3472 -0.9995 1910070 Bionet1_003299 Clc1ncc(COC(=O)c2ccc(I)cc2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A22 compound treatment 0.358 0.00658 0.34 0.362 0.0116 0.7 0.7342 0.9433 1418197 Bionet1_003300 CN1c2ccsc2C(=C(C(=S)Nc3ccccc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A23 positive control 0.083 -0.268 -13.72 0.084 -0.266 -16.08 -21.0757 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 A24 positive control 0.088 -0.263 -13.47 0.087 -0.263 -15.9 -20.7669 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B01 mock treatment 0.345 -0.00642 -0.33 0.35 -3.75E-4 -0.02 -0.2481 -0.7541 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B02 mock treatment 0.354 0.00258 0.13 0.359 0.00862 0.52 0.4615 0.8591 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B03 compound treatment 0.359 0.00758 0.39 0.358 0.00762 0.46 0.5996 0.9963 1239411 Bionet1_003301 Cn1nc(c(CN2CCN(CC2)c3ncccn3)c1Cl)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B04 compound treatment 0.36 0.00858 0.44 0.362 0.0116 0.7 0.8065 0.9744 1910071 Bionet1_003302 [O-][N+](=O)c1cc(COc2ccc(F)cc2)ccc1Sc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B05 compound treatment 0.356 0.00458 0.23 0.353 0.00262 0.16 0.2777 0.9819 1192236 Bionet1_003303 COc1ccc(Oc2c(cnn(c3ccc(C)cc3)c2=O)N4CCCCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B06 compound treatment 0.36 0.00858 0.44 0.362 0.0116 0.7 0.8065 0.9744 1910072 Bionet1_003304 Cc1ccc(OCc2ccc(Sc3ccc(Cl)cc3)c(c2)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B07 compound treatment 0.361 0.00958 0.49 0.363 0.0126 0.76 0.8853 0.9772 1910073 Bionet1_003305 Clc1ccc(NC(=O)OCCNC(=O)c2cccc(Br)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B08 compound treatment 0.356 0.00458 0.23 0.352 0.00162 0.1 0.235 0.9254 1910074 Bionet1_003306 Cc1cccc(OCc2ccc(Sc3ccc(Cl)cc3)c(c2)[N+](=O)[O-])c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B09 compound treatment 0.35 -0.00142 -0.07 0.348 -0.00238 -0.14 -0.1527 -0.9502 1910075 Bionet1_003307 O/N=C(/NC(=O)c1cccs1)\c2ccc(OCc3cnc(Cl)s3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B10 compound treatment 0.351 -4.19E-4 -0.02 0.357 0.00662 0.4 0.2676 0.6682 1910076 Bionet1_003308 Cc1ccc(Sc2ccc(COc3cccc(Cl)c3)cc2[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B11 compound treatment 0.352 5.81E-4 0.03 0.356 0.00562 0.34 0.2611 0.766 1910077 Bionet1_003309 Cc1ccc(/C=N/NC(=O)c2c(O)c3cccc4CCCn(c2=O)c43)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B12 compound treatment 0.358 0.00658 0.34 0.36 0.00962 0.58 0.6488 0.9663 1910078 Bionet1_003310 Cc1ccc(OCc2ccc(Sc3ccc(C)cc3)c(c2)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B13 compound treatment 0.356 0.00458 0.23 0.353 0.00262 0.16 0.2777 0.9819 1711158 Bionet1_003311 CCOC(CCn1ccc(O)c(Cc2ccc(Cl)cc2)c1=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B14 compound treatment 0.361 0.00958 0.49 0.353 0.00262 0.16 0.4585 0.8904 1910079 Bionet1_003312 Cc1ccc(Sc2ccc(COc3ccc(F)cc3)cc2[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B15 compound treatment 0.354 0.00258 0.13 0.357 0.00662 0.4 0.3761 0.8931 1910080 Bionet1_003313 Oc1c(C(=O)N/N=C/c2cccc(Cl)c2)c(=O)n3CCCc4cccc1c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B16 compound treatment 0.357 0.00558 0.29 0.353 0.00262 0.16 0.3138 0.9615 1587315 Bionet1_003314 Brc1ccc(cc1)n2c(cc3C(=O)CCCc32)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B17 compound treatment 0.356 0.00458 0.23 0.351 6.25E-4 0.04 0.1923 0.8106 1563407 Bionet1_003315 CC(C)(C)c1ccccc1NC(=O)c2c(O)c3cccc4CCn(c2=O)c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B18 compound treatment 0.353 0.00158 0.08 0.355 0.00462 0.28 0.2546 0.8758 1910081 Bionet1_003316 ClC1=C(CCc2ccccc12)/C=N/OCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B19 compound treatment 0.356 0.00458 0.23 0.355 0.00462 0.28 0.363 0.9962 1910082 Bionet1_003317 CCCCCCOc1ccc(/C=C/C(=O)Oc2ccc(CC(C)CC)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B20 compound treatment 0.348 -0.00342 -0.17 0.356 0.00562 0.34 0.1165 0.305 1221786 Bionet1_003318 COC(=O)c1sccc1NC(=O)COc2ccc(Cl)c3ccccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B21 compound treatment 0.363 0.0116 0.59 0.367 0.0166 1.0 1.1284 0.9683 1910083 Bionet1_003319 CCOC(=O)C1CCN(CC1)c2ncc(/C=N/NC(=O)c3ccncc3)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B22 compound treatment 0.348 -0.00342 -0.17 0.351 6.25E-4 0.04 -0.097 -0.542 1910084 Bionet1_003320 COC(=O)c1sccc1NC(=O)COc2ccc(cc2Cl)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B23 positive control 0.088 -0.263 -13.47 0.087 -0.263 -15.9 -20.7669 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 B24 positive control 0.088 -0.263 -13.47 0.087 -0.263 -15.9 -20.7669 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C01 mock treatment 0.347 -0.00442 -0.23 0.351 6.25E-4 0.04 -0.1331 -0.581 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C02 mock treatment 0.354 0.00258 0.13 0.364 0.0136 0.82 0.6749 0.8102 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C03 compound treatment 0.357 0.00558 0.29 0.351 6.25E-4 0.04 0.2285 0.7937 1910085 Bionet1_003321 FC(F)(F)c1cnc(c(Cl)c1)n2cc(cc(Cl)c2=O)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C04 compound treatment 0.36 0.00858 0.44 0.354 0.00362 0.22 0.465 0.9484 1910086 Bionet1_003322 CC(C)(C)NC(=O)c1ccc(Sc2ccc(Cl)cc2)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C05 compound treatment 0.352 5.81E-4 0.03 0.356 0.00562 0.34 0.2611 0.766 1910087 Bionet1_003323 Clc1ccc(CO/N=C/Nc2ncnc3sccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C06 compound treatment 0.352 5.81E-4 0.03 0.352 0.00162 0.1 0.0904 0.8816 1910088 Bionet1_003324 [O-][N+](=O)c1cc(ccc1Sc2ccc(Cl)cc2)C(=O)N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C07 compound treatment 0.347 -0.00442 -0.23 0.347 -0.00338 -0.2 -0.3039 -0.9987 1713117 Bionet1_003325 O=c1cc(c2ccccc2)n(o1)S(=O)(=O)c3ccc4ccccc4c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C08 compound treatment 0.356 0.00458 0.23 0.361 0.0106 0.64 0.6192 0.9068 1910089 Bionet1_003326 [O-][N+](=O)c1cc(ccc1Sc2ccc(Cl)cc2)C(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C09 compound treatment 0.356 0.00458 0.23 0.358 0.00762 0.46 0.4911 0.9509 1306768 Bionet1_003327 COc1ccc(cc1OC)S(=O)(=O)n2oc(=O)cc2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C10 compound treatment 0.363 0.0116 0.59 0.368 0.0176 1.06 1.1711 0.9617 1910090 Bionet1_003328 Cc1ccc(Sc2ccc(cc2[N+](=O)[O-])C(=O)N3CCOCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C11 compound treatment 0.362 0.0106 0.54 0.357 0.00662 0.4 0.6654 0.9889 1910091 Bionet1_003329 Cc1ccc(/C=N/NC(=O)c2ccc(OCc3c(F)cccc3Cl)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C12 compound treatment 0.353 0.00158 0.08 0.353 0.00262 0.16 0.1692 0.9512 1910092 Bionet1_003330 Cc1ccc(Sc2ccc(cc2[N+](=O)[O-])C(=O)NC3CCCCC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C13 compound treatment 0.347 -0.00442 -0.23 0.347 -0.00338 -0.2 -0.3039 -0.9987 1910093 Bionet1_003331 Clc1ccc(COc2ccc(cc2)C(=O)N/N=C/c3ccccc3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C14 compound treatment 0.355 0.00358 0.18 0.356 0.00562 0.34 0.3696 0.958 1910094 Bionet1_003332 COc1ccc(NC(=O)c2ccc(Sc3ccc(C)cc3)c(c2)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C15 compound treatment 0.367 0.0156 0.8 0.365 0.0146 0.88 1.1876 0.9987 1569085 Bionet1_003333 Nc1c(C#N)c(Nc2ccccc2)sc1C(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C16 compound treatment 0.349 -0.00242 -0.12 0.348 -0.00238 -0.14 -0.1889 -0.9973 1910095 Bionet1_003334 Cc1ccc(Sc2ccc(cc2[N+](=O)[O-])C(=O)Nc3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C17 compound treatment 0.366 0.0146 0.75 0.364 0.0136 0.82 1.1088 0.9988 1910096 Bionet1_003335 CN(C)/C=C/C(=C\C(=O)C(F)(F)F)/Nc1ccc(cc1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C18 compound treatment 0.355 0.00358 0.18 0.354 0.00362 0.22 0.2842 0.9961 1910097 Bionet1_003336 Cc1ccccc1NC(=O)c2ccc(Sc3ccc(Cl)cc3)c(c2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C19 compound treatment 0.363 0.0116 0.59 0.36 0.00962 0.58 0.8296 1.0 1602860 Bionet1_003337 CN(C)S(=O)(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)N(C)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C20 compound treatment 0.349 -0.00242 -0.12 0.355 0.00462 0.28 0.11 0.36 1910098 Bionet1_003338 [O-][N+](=O)c1cc(ccc1Sc2ccc(Cl)cc2)C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C21 compound treatment 0.354 0.00258 0.13 0.355 0.00462 0.28 0.2907 0.9414 1733864 Bionet1_003339 Clc1cc(Cl)c(OCc2ccccc2)c(Cl)c1OCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C22 compound treatment 0.348 -0.00342 -0.17 0.362 0.0116 0.7 0.3726 0.5152 1910099 Bionet1_003340 [O-][N+](=O)c1cc(ccc1Sc2ccccc2)C(=O)NC3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C23 positive control 0.084 -0.267 -13.67 0.083 -0.267 -16.14 -21.0822 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 C24 positive control 0.09 -0.261 -13.37 0.086 -0.264 -15.96 -20.7372 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D01 mock treatment 0.341 -0.0104 -0.53 0.339 -0.0114 -0.69 -0.8623 -0.9921 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D02 mock treatment 0.344 -0.00742 -0.38 0.349 -0.00138 -0.08 -0.3269 -0.8419 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D03 compound treatment 0.405 0.0536 2.74 0.412 0.0616 3.72 4.5678 0.9887 1910100 Bionet1_003341 CC1CN(CC(C)O1)c2ncc(/C=N/NC(=O)c3ccccc3O)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D04 compound treatment 0.353 0.00158 0.08 0.357 0.00662 0.4 0.34 0.8332 1639700 Bionet1_003342 Cc1nn(C)c(Oc2ccccc2)c1CCNC(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D05 compound treatment 0.373 0.0216 1.1 0.391 0.0406 2.45 2.5144 0.935 1910101 Bionet1_003343 C1CN(CCO1)c2ncc(/C=N/Nc3ccccc3Oc4ccccc4)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D06 compound treatment 0.347 -0.00442 -0.23 0.347 -0.00338 -0.2 -0.3039 -0.9987 1534636 Bionet1_003344 Cc1nn(C)c(Oc2ccccc2)c1CCNS(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D07 compound treatment 0.365 0.0136 0.69 0.359 0.00862 0.52 0.8592 0.9899 1910102 Bionet1_003345 O=C(N/N=C/c1cnc(s1)N2CCN(CC2)c3ccccc3)c4cccnc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D08 compound treatment 0.348 -0.00342 -0.17 0.347 -0.00338 -0.2 -0.2677 -0.9971 1581523 Bionet1_003346 Cc1nn(C)c(Oc2ccccc2)c1CCNC(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D09 compound treatment 0.35 -0.00142 -0.07 0.354 0.00362 0.22 0.1034 0.4486 1910103 Bionet1_003347 Oc1c(C(=O)N/N=C/c2c[nH]c3ccccc23)c(=O)n4CCCc5cccc1c54 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D10 compound treatment 0.348 -0.00342 -0.17 0.357 0.00662 0.4 0.1592 0.3647 1485173 Bionet1_003348 Cc1nn(C)c(Oc2ccccc2)c1CCNC(=O)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D11 compound treatment 0.349 -0.00242 -0.12 0.348 -0.00238 -0.14 -0.1889 -0.9973 1910104 Bionet1_003349 Oc1cccc(/C=N/NC(=O)c2c(O)c3cccc4CCCn(c2=O)c43)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D12 compound treatment 0.356 0.00458 0.23 0.351 6.25E-4 0.04 0.1923 0.8106 1455182 Bionet1_003350 Cc1nn(C)c(Oc2ccccc2)c1CCNS(=O)(=O)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D13 compound treatment 0.349 -0.00242 -0.12 0.34 -0.0104 -0.63 -0.5304 -0.8307 1910105 Bionet1_003351 FC(F)(F)c1ccc(cc1)C(=O)N/N=C/c2cnc(s2)N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D14 compound treatment 0.34 -0.0114 -0.58 0.343 -0.00737 -0.45 -0.7277 -0.991 1910106 Bionet1_003352 Clc1ccc(N/N=C/2\CCS(=O)(=O)c3sccc23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D15 compound treatment 0.346 -0.00542 -0.28 0.346 -0.00438 -0.26 -0.3827 -0.9997 1910107 Bionet1_003353 FC(F)(F)c1cc(NC(=S)NC(=O)c2ccccc2)ccc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D16 compound treatment 0.349 -0.00242 -0.12 0.345 -0.00538 -0.32 -0.3169 -0.9126 1910108 Bionet1_003354 FC(F)(F)c1cccc(c1)C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D17 compound treatment 0.345 -0.00642 -0.33 0.345 -0.00538 -0.32 -0.4615 -1.0 1910109 Bionet1_003355 CC(C)c1ccc(Sc2ncnc3n(Cc4ccccc4)c(C)c(C)c23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D18 compound treatment 0.344 -0.00742 -0.38 0.347 -0.00338 -0.2 -0.4123 -0.9575 1910110 Bionet1_003356 COc1ccc(cc1)C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D19 compound treatment 0.368 0.0166 0.85 0.362 0.0116 0.7 1.0957 0.9956 1910111 Bionet1_003357 Cn1c2sc(cc2c3ccccc13)C(=O)NNC(=O)c4c(F)cccc4F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D20 compound treatment 0.347 -0.00442 -0.23 0.347 -0.00338 -0.2 -0.3039 -0.9987 1910112 Bionet1_003358 Fc1cccc(F)c1C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D21 compound treatment 0.369 0.0176 0.9 0.377 0.0266 1.61 1.7722 0.9623 1910113 Bionet1_003359 Cn1c2sc(cc2c3ccccc13)C(=O)NNC(=O)c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D22 compound treatment 0.342 -0.00942 -0.48 0.338 -0.0124 -0.75 -0.8688 -0.9775 1910114 Bionet1_003360 Cc1ccc(CSc2nc(Sc3ccc(C)cc3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D23 positive control 0.087 -0.264 -13.52 0.085 -0.265 -16.02 -20.8884 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 D24 positive control 0.09 -0.261 -13.37 0.088 -0.262 -15.84 -20.6519 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E01 mock treatment 0.346 -0.00542 -0.28 0.346 -0.00438 -0.26 -0.3827 -0.9997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E02 mock treatment 0.35 -0.00142 -0.07 0.357 0.00662 0.4 0.2315 0.5695 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E03 compound treatment 0.343 -0.00842 -0.43 0.344 -0.00638 -0.38 -0.5765 -0.9984 1910115 Bionet1_003361 COC(=O)c1ccc(Oc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E04 compound treatment 0.378 0.0266 1.36 0.379 0.0286 1.73 2.183 0.9929 1910116 Bionet1_003362 [O-][N+](=O)c1cc(ccc1Sc2ccccc2)C(=O)Nc3ccc(F)cc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E05 compound treatment 0.379 0.0276 1.41 0.374 0.0236 1.43 2.0057 1.0 1910117 Bionet1_003363 Clc1ccc(COc2ccc(cc2)C(=O)N/N=C/c3ccco3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E06 compound treatment 0.398 0.0466 2.38 0.387 0.0366 2.21 3.2476 0.9993 1910118 Bionet1_003364 COc1ccc(NC(=O)c2ccc(Sc3ccccc3)c(c2)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E07 compound treatment 0.441 0.0896 4.58 0.43 0.0796 4.81 6.6378 0.9997 1910119 Bionet1_003365 CN(N1C(=O)c2cccc(O)c2C1=O)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E08 compound treatment 0.409 0.0576 2.94 0.406 0.0556 3.36 4.4563 0.9979 1714600 Bionet1_003366 CN1c2ccsc2C(=C(C(=S)Nc3ccc(Cl)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E09 compound treatment 0.377 0.0256 1.31 0.374 0.0236 1.43 1.9334 0.9991 1910120 Bionet1_003367 CN(N1C(=O)c2cccc(N)c2C1=O)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E10 compound treatment 0.423 0.0716 3.66 0.422 0.0716 4.32 5.6455 0.9966 1161142 Bionet1_003368 CN1c2ccsc2C(=C(C(=S)Nc3ccc(C)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E11 compound treatment 0.458 0.107 5.45 0.431 0.0806 4.87 7.2952 0.9984 1502713 Bionet1_003369 Nc1c(C#N)c(Nc2ccccc2)sc1C(=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E12 compound treatment 0.38 0.0286 1.46 0.366 0.0156 0.94 1.7003 0.9776 1910121 Bionet1_003370 C(Sc1nc(NC2CCCCC2)c3sccc3n1)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E13 compound treatment 0.355 0.00358 0.18 0.361 0.0106 0.64 0.583 0.874 1179126 Bionet1_003371 COc1ccc(cc1)C2CC(=O)Nc3c2c(nn3c4ccccc4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E14 compound treatment 0.345 -0.00642 -0.33 0.346 -0.00438 -0.26 -0.4189 -0.9942 1910122 Bionet1_003372 Clc1ccc(OCC(=O)NN=C(c2ccccc2)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E15 compound treatment 0.361 0.00958 0.49 0.358 0.00762 0.46 0.6719 0.9995 1910123 Bionet1_003373 CCOC(=O)C1=C(C)N(N(C)c2ncc(cc2Cl)C(F)(F)F)C(=O)CC1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E16 compound treatment 0.343 -0.00842 -0.43 0.345 -0.00538 -0.32 -0.5339 -0.9903 1910124 Bionet1_003374 COc1ccc(OCC(=O)NN=C(c2ccccc2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E17 compound treatment 0.349 -0.00242 -0.12 0.353 0.00262 0.16 0.0246 0.1223 1302194 Bionet1_003375 O=C(c1sc(Nc2ccccc2)c(C#N)c1n3cccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E18 compound treatment 0.342 -0.00942 -0.48 0.348 -0.00238 -0.14 -0.4419 -0.8795 1910125 Bionet1_003376 Cc1ccc(OCC(=O)NN=C(c2ccccc2)c3ccccc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E19 compound treatment 0.344 -0.00742 -0.38 0.35 -3.75E-4 -0.02 -0.2843 -0.748 1910126 Bionet1_003377 N#CC1=C(Nc2ccccc2)SC=C(N=C1N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E20 compound treatment 0.342 -0.00942 -0.48 0.348 -0.00238 -0.14 -0.4419 -0.8795 1910127 Bionet1_003378 O=C(COc1ccc2ccccc2c1)NN=C(c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E21 compound treatment 0.356 0.00458 0.23 0.361 0.0106 0.64 0.6192 0.9068 1910128 Bionet1_003379 O=C(NC(=S)Nc1ccc(N=Nc2ccccc2)cc1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E22 compound treatment 0.354 0.00258 0.13 0.352 0.00162 0.1 0.1627 0.9893 1910129 Bionet1_003380 Clc1ccc(SCC(=O)NN=C(c2ccccc2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E23 positive control 0.085 -0.266 -13.62 0.084 -0.266 -16.08 -21.0034 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 E24 positive control 0.092 -0.259 -13.26 0.089 -0.261 -15.78 -20.5369 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F01 mock treatment 0.35 -0.00142 -0.07 0.348 -0.00238 -0.14 -0.1527 -0.9502 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F02 mock treatment 0.357 0.00558 0.29 0.353 0.00262 0.16 0.3138 0.9615 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F03 compound treatment 0.355 0.00358 0.18 0.352 0.00162 0.1 0.1988 0.9572 1519261 Bionet1_003381 Clc1ccc(SCC2CSc3nc4ccccc4c(=O)n23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F04 compound treatment 0.376 0.0246 1.26 0.38 0.0296 1.79 2.1533 0.9851 1910130 Bionet1_003382 Clc1ccc(cn1)C(=O)O/N=C/2\CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F05 compound treatment 0.365 0.0136 0.69 0.349 -0.00138 -0.08 0.4323 0.6182 1910131 Bionet1_003383 Cc1ccccc1C(=O)NNC(=O)c2cc3c(s2)n(C)c4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F06 compound treatment 0.363 0.0116 0.59 0.364 0.0136 0.82 1.0003 0.987 1264965 Bionet1_003384 CN(C(=O)CN(c1ccc(Cl)cc1Cl)S(=O)(=O)C)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F07 compound treatment 0.372 0.0206 1.05 0.379 0.0286 1.73 1.966 0.9717 1910132 Bionet1_003385 Cc1cccc(c1)C(=O)NNC(=O)c2cc3c(s2)n(C)c4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F08 compound treatment 0.363 0.0116 0.59 0.359 0.00862 0.52 0.7869 0.9979 1298187 Bionet1_003386 CS(=O)(=O)N(CC(=O)N1CCOCC1)c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F09 compound treatment 0.358 0.00658 0.34 0.358 0.00762 0.46 0.5634 0.9881 1910133 Bionet1_003387 Cc1ccc(cc1)C(=O)NNC(=O)c2cc3c(s2)n(C)c4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F10 compound treatment 0.351 -4.19E-4 -0.02 0.333 -0.0174 -1.05 -0.7568 -0.7214 1237863 Bionet1_003388 Cc1ccc(CSc2nc(Oc3cc(C)cc(C)c3)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F11 compound treatment 0.356 0.00458 0.23 0.365 0.0146 0.88 0.7899 0.8648 1910134 Bionet1_003389 Cn1c2sc(cc2c3ccccc13)C(=O)NNC(=O)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F12 compound treatment 0.357 0.00558 0.29 0.349 -0.00138 -0.08 0.1431 0.4815 1735998 Bionet1_003390 Cc1ccc(CSc2nc(Oc3ccc(F)cc3F)c4CCCCc4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F13 compound treatment 0.349 -0.00242 -0.12 0.348 -0.00238 -0.14 -0.1889 -0.9973 1220641 Bionet1_003391 Clc1ccc(SCC2CSc3nc4ccccc4c(=O)n23)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F14 compound treatment 0.345 -0.00642 -0.33 0.354 0.00362 0.22 -0.0774 -0.1961 1910135 Bionet1_003392 CSc1nc(Sc2ccc(Cl)cc2Cl)c3sccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F15 compound treatment 0.347 -0.00442 -0.23 0.36 0.00962 0.58 0.2511 0.4027 1440657 Bionet1_003393 COc1ccc(cc1)c2cc(on2)C(=O)Nc3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F16 compound treatment 0.345 -0.00642 -0.33 0.349 -0.00138 -0.08 -0.2908 -0.8589 1910136 Bionet1_003394 CSc1nc(Sc2cccc(c2)C(F)(F)F)c3sccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F17 compound treatment 0.339 -0.0124 -0.64 0.344 -0.00638 -0.38 -0.7212 -0.9712 1910137 Bionet1_003395 OC(CS(=O)(=O)c1ccc(Cl)cc1)c2ccc(Cl)c(Cl)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F18 compound treatment 0.341 -0.0104 -0.53 0.351 6.25E-4 0.04 -0.35 -0.6554 1910138 Bionet1_003396 FC(F)(F)c1cccc(CO/N=C/Nc2ncnc3sccc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F19 compound treatment 0.359 0.00758 0.39 0.351 6.25E-4 0.04 0.3008 0.7723 1444095 Bionet1_003397 Clc1ccccc1SCC2CSc3nc4ccccc4c(=O)n23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F20 compound treatment 0.353 0.00158 0.08 0.349 -0.00138 -0.08 -0.0015 -0.0133 1910139 Bionet1_003398 FC(F)(F)c1cccc(OCCO/N=C/Nc2ncnc3sccc23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F21 compound treatment 0.354 0.00258 0.13 0.355 0.00462 0.28 0.2907 0.9414 1434562 Bionet1_003399 Clc1cccc(SCC2CSc3nc4ccccc4c(=O)n23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F22 compound treatment 0.351 -4.19E-4 -0.02 0.356 0.00562 0.34 0.225 0.6611 1910140 Bionet1_003400 Clc1cccc(Cl)c1CO/N=C/Nc2ncnc3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F23 positive control 0.09 -0.261 -13.37 0.086 -0.264 -15.96 -20.7372 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 F24 positive control 0.091 -0.26 -13.32 0.089 -0.261 -15.78 -20.573 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G01 mock treatment 0.347 -0.00442 -0.23 0.336 -0.0144 -0.87 -0.7734 -0.8625 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G02 mock treatment 0.347 -0.00442 -0.23 0.347 -0.00338 -0.2 -0.3039 -0.9987 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G03 compound treatment 0.373 0.0216 1.1 0.375 0.0246 1.49 1.8314 0.9892 1910141 Bionet1_003401 Nc1cccc2C(=O)N(CCNc3ncc(cc3Cl)C(F)(F)F)C(=O)c21 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G04 compound treatment 0.341 -0.0104 -0.53 0.326 -0.0244 -1.47 -1.4172 -0.9056 1910142 Bionet1_003402 Cc1ccc(SCC(=O)NN=C(c2ccccc2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G05 compound treatment 0.349 -0.00242 -0.12 0.345 -0.00538 -0.32 -0.3169 -0.9126 1910143 Bionet1_003403 Fc1ccc(COc2ccsc2C(=O)N/N=C/c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G06 compound treatment 0.339 -0.0124 -0.64 0.325 -0.0254 -1.53 -1.5322 -0.924 1910144 Bionet1_003404 COc1cccc(SCC(=O)NN=C(c2ccccc2)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G07 compound treatment 0.344 -0.00742 -0.38 0.344 -0.00638 -0.38 -0.5404 -1.0 1910145 Bionet1_003405 Cc1ccc(/C=N/NC(=O)c2sccc2OCc3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G08 compound treatment 0.383 0.0316 1.61 0.37 0.0196 1.18 1.9796 0.9884 1910146 Bionet1_003406 Clc1ccc2SCCC(=Nc2c1)SCc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G09 compound treatment 0.343 -0.00842 -0.43 0.338 -0.0124 -0.75 -0.8327 -0.9657 1910147 Bionet1_003407 Fc1ccc(COc2ccsc2C(=O)N/N=C/c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G10 compound treatment 0.342 -0.00942 -0.48 0.343 -0.00737 -0.45 -0.6554 -0.9992 1910148 Bionet1_003408 CC(C)(C)C(=O)Cn1ncc(Br)c(Br)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G11 compound treatment 0.337 -0.0144 -0.74 0.333 -0.0174 -1.05 -1.263 -0.9851 1910149 Bionet1_003409 Cc1ccsc1/C=N/NC(=O)c2sccc2OCc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G12 compound treatment 0.354 0.00258 0.13 0.353 0.00262 0.16 0.2054 0.9959 1910150 Bionet1_003410 Clc1ccc(CSC2=Nc3cc(Cl)ccc3SCC2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G13 compound treatment 0.338 -0.0134 -0.69 0.338 -0.0124 -0.75 -1.0134 -0.9991 1910151 Bionet1_003411 Fc1ccc(COc2ccsc2C(=O)N/N=C/c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G14 compound treatment 0.359 0.00758 0.39 0.365 0.0146 0.88 0.8984 0.9317 1910152 Bionet1_003412 Clc1cccc(CSC2=Nc3cc(Cl)ccc3SCC2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G15 compound treatment 0.349 -0.00242 -0.12 0.349 -0.00138 -0.08 -0.1462 -0.9812 1910153 Bionet1_003413 Fc1ccc(COc2ccsc2C(=O)N/N=C/c3ccncc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G16 compound treatment 0.344 -0.00742 -0.38 0.34 -0.0104 -0.63 -0.7111 -0.9711 1393961 Bionet1_003414 Clc1ccc(cc1)C(=O)Cn2ncc(N3CCCC3)c(Br)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G17 compound treatment 0.348 -0.00342 -0.17 0.345 -0.00538 -0.32 -0.3531 -0.9579 1427809 Bionet1_003415 Oc1c(C(=O)NCc2ccc(F)cc2)c(=O)n3CCCc4cccc1c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G18 compound treatment 0.33 -0.0214 -1.1 0.337 -0.0134 -0.81 -1.3454 -0.9888 1910154 Bionet1_003416 COC(=O)c1ccc2SCC(=O)N(Cc3cccc(c3)C(F)(F)F)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G19 compound treatment 0.348 -0.00342 -0.17 0.342 -0.00837 -0.51 -0.4811 -0.8994 1522331 Bionet1_003417 Oc1c(C(=O)Nc2cc(Cl)cc(Cl)c2)c(=O)n3CCCc4cccc1c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G20 compound treatment 0.352 5.81E-4 0.03 0.35 -3.75E-4 -0.02 0.005 0.1336 1910155 Bionet1_003418 CN1c2ccccc2C(=C(C(=O)Nc3cccc(Cl)c3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G21 compound treatment 0.339 -0.0124 -0.64 0.344 -0.00638 -0.38 -0.7212 -0.9712 1680892 Bionet1_003419 Clc1ccc(cc1)C(=O)CSc2nnc(SC3CCCC3)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G22 compound treatment 0.347 -0.00442 -0.23 0.349 -0.00138 -0.08 -0.2185 -0.9076 1910156 Bionet1_003420 CN1c2ccccc2C(=C(C(=O)Nc3cccc(c3)C(F)(F)F)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G23 positive control 0.088 -0.263 -13.47 0.086 -0.264 -15.96 -20.8095 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 G24 positive control 0.095 -0.256 -13.11 0.091 -0.259 -15.66 -20.343 -0.9961 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H01 mock treatment 0.354 0.00258 0.13 0.349 -0.00138 -0.08 0.0346 0.222 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H02 mock treatment 0.353 0.00158 0.08 0.358 0.00762 0.46 0.3826 0.8187 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H03 compound treatment 0.35 -0.00142 -0.07 0.347 -0.00338 -0.2 -0.1954 -0.9034 1358708 Bionet1_003421 Clc1cccc(SCC2CSc3nc4ccccc4c(=O)n23)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H04 compound treatment 0.344 -0.00742 -0.38 0.339 -0.0114 -0.69 -0.7538 -0.9609 1910157 Bionet1_003422 FC(=C(F)CCSc1nc2ccsc2c(=O)n1c3ccccc3)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H05 compound treatment 0.352 5.81E-4 0.03 0.349 -0.00138 -0.08 -0.0377 -0.4277 1457919 Bionet1_003423 Clc1ccc(Cl)c(SCC2CSc3nc4ccccc4c(=O)n23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H06 compound treatment 0.388 0.0366 1.87 0.386 0.0356 2.15 2.8433 0.9976 1910158 Bionet1_003424 COC(=O)/C(=C\Nc1ccccc1N)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H07 compound treatment 0.342 -0.00942 -0.48 0.346 -0.00438 -0.26 -0.5273 -0.96 1377998 Bionet1_003425 Clc1ccc(CSCC2CSc3nc4ccccc4c(=O)n23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H08 compound treatment 0.346 -0.00542 -0.28 0.35 -3.75E-4 -0.02 -0.2119 -0.7623 1027931 Bionet1_003426 Clc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H09 compound treatment 0.362 0.0106 0.54 0.354 0.00362 0.22 0.5373 0.9207 1910159 Bionet1_003427 Cc1ccc(cc1)S(=O)(=O)NNC(=O)c2cc3c(s2)n(C)c4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H10 compound treatment 0.351 -4.19E-4 -0.02 0.347 -0.00338 -0.2 -0.1592 -0.7772 1910160 Bionet1_003428 COc1cccc(CNS(=O)(=O)/C=C/c2ccc(OC)c(OC)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H11 compound treatment 0.352 5.81E-4 0.03 0.337 -0.0134 -0.81 -0.5499 -0.6806 1456037 Bionet1_003429 Clc1ccc(CSC2=CS(=O)(=O)c3ccccc3N2)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H12 compound treatment 0.407 0.0556 2.84 0.402 0.0516 3.12 4.2133 0.9989 1326910 Bionet1_003430 CCOC(=O)c1c2ccc(OCC(=O)NCc3ccco3)cc2n4ccccc14 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H13 compound treatment 0.349 -0.00242 -0.12 0.336 -0.0144 -0.87 -0.7011 -0.7998 1910161 Bionet1_003431 Fc1cccc(Cl)c1CSC2=CS(=O)(=O)c3ccccc3N2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H14 compound treatment 0.346 -0.00542 -0.28 0.363 0.0126 0.76 0.343 0.4229 1910162 Bionet1_003432 FC(F)(F)c1cccc(COc2ccc3c(C#N)c4ccccn4c3c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H15 compound treatment 0.363 0.0116 0.59 0.36 0.00962 0.58 0.8296 1.0 1910163 Bionet1_003433 Cn1c2sc(cc2c3ccccc13)C(=O)NNC(=O)Cc4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H16 compound treatment 0.352 5.81E-4 0.03 0.35 -3.75E-4 -0.02 0.005 0.1336 1910164 Bionet1_003434 FC(F)(F)c1cnc(Oc2ccc3c(C#N)c4ccccn4c3c2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H17 compound treatment 0.355 0.00358 0.18 0.35 -3.75E-4 -0.02 0.1135 0.615 1910165 Bionet1_003435 COC(=O)c1sccc1NC(=O)CSc2ccccc2C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H18 compound treatment 0.346 -0.00542 -0.28 0.348 -0.00238 -0.14 -0.2973 -0.953 1303648 Bionet1_003436 COc1ccc(NC(=O)COc2ccc3c(C#N)c4ccccn4c3c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H19 compound treatment 0.343 -0.00842 -0.43 0.339 -0.0114 -0.69 -0.79 -0.9747 1910166 Bionet1_003437 COC(=O)c1sccc1NC(=O)CSc2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H20 compound treatment 0.353 0.00158 0.08 0.348 -0.00238 -0.14 -0.0442 -0.2687 1127807 Bionet1_003438 CSc1nc(Oc2ccc(cc2)C(C)(C)C)c3cnn(c4ccccc4)c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H21 compound treatment 0.356 0.00458 0.23 0.356 0.00562 0.34 0.4057 0.9836 1910167 Bionet1_003439 [O-][N+](=O)c1cc(CN2CCOCC2)ccc1Sc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H22 compound treatment 0.351 -4.19E-4 -0.02 0.342 -0.00837 -0.51 -0.3727 -0.7364 1147845 Bionet1_003440 CCCCn1c(NC(=O)C(C)C)c(C#N)c(c1c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H23 positive control 0.088 -0.263 -13.47 0.088 -0.262 -15.84 -20.7242 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 H24 positive control 0.099 -0.252 -12.91 0.093 -0.257 -15.54 -20.113 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I01 mock treatment 0.348 -0.00342 -0.17 0.346 -0.00438 -0.26 -0.3104 -0.9799 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I02 mock treatment 0.352 5.81E-4 0.03 0.355 0.00462 0.28 0.2184 0.7779 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I03 compound treatment 0.366 0.0146 0.75 0.364 0.0136 0.82 1.1088 0.9988 1160435 Bionet1_003441 COc1cccc(Cn2ccc(O)c(Cc3ccc(Cl)cc3)c2=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I04 compound treatment 0.347 -0.00442 -0.23 0.349 -0.00138 -0.08 -0.2185 -0.9076 1342213 Bionet1_003442 CN1c2ccccc2C(=C(C(=O)Nc3c(C)cccc3C)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I05 compound treatment 0.346 -0.00542 -0.28 0.353 0.00262 0.16 -0.0839 -0.2628 1910168 Bionet1_003443 Oc1c(C(=O)Nc2cccc(c2)[N+](=O)[O-])c(=O)n3CCCc4cccc1c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I06 compound treatment 0.349 -0.00242 -0.12 0.353 0.00262 0.16 0.0246 0.1223 1282139 Bionet1_003444 CN1c2ccccc2C(=C(C(=O)Nc3ccc(Cl)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I07 compound treatment 0.346 -0.00542 -0.28 0.352 0.00162 0.1 -0.1266 -0.4306 1694746 Bionet1_003445 Oc1c(C(=O)Nc2cc(F)ccc2F)c(=O)n3CCCc4cccc1c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I08 compound treatment 0.345 -0.00642 -0.33 0.358 0.00762 0.46 0.0934 0.1652 1910169 Bionet1_003446 CN1c2ccccc2C(=C(C(=O)Nc3ccc(Cl)c(Cl)c3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I09 compound treatment 0.344 -0.00742 -0.38 0.328 -0.0224 -1.35 -1.2234 -0.872 1609852 Bionet1_003447 COc1ccc(CCn2ccc(O)c(Cc3ccc(Cl)cc3)c2=O)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I10 compound treatment 0.366 0.0146 0.75 0.367 0.0166 1.0 1.2368 0.9893 1910170 Bionet1_003448 Clc1ccc2SCCC(=Nc2c1)SCc3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I11 compound treatment 0.344 -0.00742 -0.38 0.362 0.0116 0.7 0.228 0.2858 1910171 Bionet1_003449 Cc1ccc(COc2ccc(cc2)C(=O)N/N=C/C=C\c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I12 compound treatment 0.375 0.0236 1.21 0.362 0.0116 0.7 1.3488 0.9668 1910172 Bionet1_003450 Clc1ccc(CSC2=Nc3cc(Cl)ccc3SCC2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I13 compound treatment 0.365 0.0136 0.69 0.363 0.0126 0.76 1.0299 0.9989 1910173 Bionet1_003451 [O-][N+](=O)c1ccc(CO/N=C/CC(=O)c2cc(no2)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I14 compound treatment 0.382 0.0306 1.56 0.382 0.0316 1.91 2.4556 0.9951 1910174 Bionet1_003452 Cc1ccc(Sc2ccc(COC(=O)c3cccs3)cc2[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I15 compound treatment 0.346 -0.00542 -0.28 0.355 0.00462 0.28 0.0015 0.0038 1910175 Bionet1_003453 CCOc1ccc(Br)cc1/C=N/NC(=O)c2ccccc2O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I16 compound treatment 0.37 0.0186 0.95 0.377 0.0266 1.61 1.8083 0.9685 1910176 Bionet1_003454 [O-][N+](=O)c1cc(COC(=O)c2ccc(Cl)cc2)ccc1Sc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I17 compound treatment 0.388 0.0366 1.87 0.379 0.0286 1.73 2.5445 0.9992 1910177 Bionet1_003455 Oc1ccccc1/C=N/NC(=O)c2ccc(OCc3c(F)cccc3Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I18 compound treatment 0.36 0.00858 0.44 0.35 -3.75E-4 -0.02 0.2942 0.6697 1910178 Bionet1_003456 CCNC(=O)OCc1ccc(Sc2ccc(Cl)cc2)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I19 compound treatment 0.347 -0.00442 -0.23 0.356 0.00562 0.34 0.0803 0.1969 1910179 Bionet1_003457 CC(C)(C)c1ccc(Oc2ccccc2/C=C/3\SC(=O)NC3=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I20 compound treatment 0.369 0.0176 0.9 0.364 0.0136 0.82 1.2173 0.999 1910180 Bionet1_003458 [O-][N+](=O)c1cc(COC(=O)Nc2ccc(F)cc2)ccc1Sc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I21 compound treatment 0.358 0.00658 0.34 0.347 -0.00338 -0.2 0.0939 0.2386 1910181 Bionet1_003459 Clc1ncc(COc2ccc(/C=N/NC(=O)c3ccncc3)cc2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I22 compound treatment 0.342 -0.00942 -0.48 0.345 -0.00538 -0.32 -0.57 -0.9815 1487542 Bionet1_003460 COC(=O)c1ccc2SCC(=O)N(Cc3ccc(Cl)cc3Cl)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I23 positive control 0.088 -0.263 -13.47 0.087 -0.263 -15.9 -20.7669 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 I24 positive control 0.095 -0.256 -13.11 0.093 -0.257 -15.54 -20.2576 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J01 mock treatment 0.349 -0.00242 -0.12 0.349 -0.00138 -0.08 -0.1462 -0.9812 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J02 mock treatment 0.359 0.00758 0.39 0.354 0.00362 0.22 0.4288 0.9634 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J03 compound treatment 0.336 -0.0154 -0.79 0.332 -0.0184 -1.11 -1.3419 -0.986 1910182 Bionet1_003461 [O-][N+](=O)c1cc(CN2CCCCC2)ccc1Sc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J04 compound treatment 0.38 0.0286 1.46 0.382 0.0316 1.91 2.3833 0.9913 1426452 Bionet1_003462 Cc1c(C)n(Cc2ccccc2)c(NC(=O)c3ccccc3Cl)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J05 compound treatment 0.358 0.00658 0.34 0.356 0.00562 0.34 0.478 1.0 1910183 Bionet1_003463 COC(=O)c1sccc1NC(=O)CSc2cccc(Cl)c2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J06 compound treatment 0.36 0.00858 0.44 0.362 0.0116 0.7 0.8065 0.9744 1646382 Bionet1_003464 Cc1c(C)n(Cc2ccccc2)c(NC(=O)c3cccc(Cl)c3)c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J07 compound treatment 0.359 0.00758 0.39 0.359 0.00862 0.52 0.6423 0.9894 1910184 Bionet1_003465 COC(=O)c1sccc1NC(=O)CSc2cc(Cl)ccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J08 compound treatment 0.344 -0.00742 -0.38 0.344 -0.00638 -0.38 -0.5404 -1.0 1910185 Bionet1_003466 CO/N=C(/CNS(=O)(=O)c1ccc(OC)cc1)\c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J09 compound treatment 0.363 0.0116 0.59 0.354 0.00362 0.22 0.5735 0.9084 1910186 Bionet1_003467 COC(=O)c1sccc1NC(=O)CN2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J10 compound treatment 0.354 0.00258 0.13 0.358 0.00762 0.46 0.4188 0.8746 1498526 Bionet1_003468 Clc1cccc(Cl)c1SC2CCS(=O)(=O)c3sccc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J11 compound treatment 0.349 -0.00242 -0.12 0.349 -0.00138 -0.08 -0.1462 -0.9812 1910187 Bionet1_003469 FC(F)(F)c1ccc(cc1)C(=O)N/N=C/c2c[nH]nc2c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J12 compound treatment 0.353 0.00158 0.08 0.351 6.25E-4 0.04 0.0838 0.9398 1390228 Bionet1_003470 Fc1ccc(Oc2cc(nc(n2)c3ccccc3)N4CCOCC4)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J13 compound treatment 0.334 -0.0174 -0.89 0.347 -0.00338 -0.2 -0.7739 -0.847 1910188 Bionet1_003471 Oc1ccn(Cc2cccc(Cl)c2)c(=O)c1C/C=C/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J14 compound treatment 0.341 -0.0104 -0.53 0.341 -0.00937 -0.57 -0.7769 -0.9995 1588462 Bionet1_003472 O=S(=O)(c1ccccc1)c2cnc(nc2N3CCCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J15 compound treatment 0.37 0.0186 0.95 0.361 0.0106 0.64 1.1254 0.9817 1910189 Bionet1_003473 Oc1ccn(Cc2cccc(c2)C(F)(F)F)c(=O)c1C/C=C/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J16 compound treatment 0.377 0.0256 1.31 0.372 0.0216 1.31 1.848 1.0 1910190 Bionet1_003474 FC(F)(F)c1cccc(Sc2nccc(n2)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J17 compound treatment 0.368 0.0166 0.85 0.352 0.00162 0.1 0.6689 0.7837 1910191 Bionet1_003475 CCOC(=O)/C(=C/N(C)C)/NC=C(C(=O)c1ccccc1)C(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J18 compound treatment 0.335 -0.0164 -0.84 0.335 -0.0154 -0.93 -1.25 -0.9987 1583381 Bionet1_003476 Cc1ccc(cc1)S(=O)(=O)c2cnc(nc2N3CCCCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J19 compound treatment 0.351 -4.19E-4 -0.02 0.354 0.00362 0.22 0.1396 0.6348 1910192 Bionet1_003477 O=C(C(=CNc1cnc2ccccn2c1=O)C(=O)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J20 compound treatment 0.35 -0.00142 -0.07 0.343 -0.00737 -0.45 -0.3661 -0.8117 1183782 Bionet1_003478 Cc1cc(Cl)ccc1Oc2nc(ncc2S(=O)(=O)C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J21 compound treatment 0.354 0.00258 0.13 0.349 -0.00138 -0.08 0.0346 0.222 1910193 Bionet1_003479 O=C(N/N=C/c1cnc(s1)S(=O)(=O)c2ccccc2)c3ccco3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J22 compound treatment 0.35 -0.00142 -0.07 0.354 0.00362 0.22 0.1034 0.4486 1427611 Bionet1_003480 CN1CCN(CC1)c2nc(ncc2S(=O)(=O)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J23 positive control 0.088 -0.263 -13.47 0.086 -0.264 -15.96 -20.8095 -0.9964 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 J24 positive control 0.093 -0.258 -13.21 0.093 -0.257 -15.54 -20.33 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K01 mock treatment 0.354 0.00258 0.13 0.347 -0.00338 -0.2 -0.0508 -0.2091 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K02 mock treatment 0.348 -0.00342 -0.17 0.35 -3.75E-4 -0.02 -0.1396 -0.7921 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K03 compound treatment 0.353 0.00158 0.08 0.353 0.00262 0.16 0.1692 0.9512 1910194 Bionet1_003481 Clc1ncc(COc2ccc(/C=C\3/SC(=O)NC3=O)cc2)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K04 compound treatment 0.339 -0.0124 -0.64 0.343 -0.00737 -0.45 -0.7639 -0.9849 1910195 Bionet1_003482 CC(Sc1ccc(C)cc1)C(=O)NN=C(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K05 compound treatment 0.374 0.0226 1.15 0.378 0.0276 1.67 1.9957 0.9839 1194760 Bionet1_003483 O=C(C1CN(CC1C(=O)c2ccccc2)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K06 compound treatment 0.336 -0.0154 -0.79 0.333 -0.0174 -1.05 -1.2992 -0.9901 1910196 Bionet1_003484 CC(Sc1ccccc1)C(=O)NN=C(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K07 compound treatment 0.343 -0.00842 -0.43 0.346 -0.00438 -0.26 -0.4912 -0.9725 1709080 Bionet1_003485 Cc1ccc(cc1)C(=O)C2CN(CC2C(=O)c3ccc(C)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K08 compound treatment 0.323 -0.0284 -1.45 0.329 -0.0214 -1.29 -1.94 -0.9982 1910197 Bionet1_003486 COc1cccc(SC(C)C(=O)NN=C(c2ccccc2)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K09 compound treatment 0.342 -0.00942 -0.48 0.34 -0.0104 -0.63 -0.7834 -0.9916 1260235 Bionet1_003487 Oc1c(C(=O)NCc2cccc(Cl)c2)c(=O)n3CCCc4cccc1c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K10 compound treatment 0.324 -0.0274 -1.4 0.326 -0.0244 -1.47 -2.0319 -0.9997 1910198 Bionet1_003488 CC(Sc1ccc(Cl)cc1)C(=O)NN=C(c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K11 compound treatment 0.349 -0.00242 -0.12 0.346 -0.00438 -0.26 -0.2742 -0.9403 1910199 Bionet1_003489 CC(C)(C)c1cc(C#N)c(OCc2ccc(cc2)C(F)(F)F)c(C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K12 compound treatment 0.356 0.00458 0.23 0.354 0.00362 0.22 0.3204 0.9994 1910200 Bionet1_003490 CC1CN(CC(=O)NN=C(c2ccccc2)c3ccccc3)CC(C)O1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K13 compound treatment 0.348 -0.00342 -0.17 0.356 0.00562 0.34 0.1165 0.305 1910201 Bionet1_003491 CCCc1ccc(c(F)c1)c2ccc(cc2)C(=O)Cc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K14 compound treatment 0.365 0.0136 0.69 0.353 0.00262 0.16 0.6031 0.8467 1910202 Bionet1_003492 O=C(CN1CCN(CC1)c2ncccn2)NN=C(c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K15 compound treatment 0.349 -0.00242 -0.12 0.345 -0.00538 -0.32 -0.3169 -0.9126 1910203 Bionet1_003493 Brc1nc(Br)n(n1)C(=O)OCc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K16 compound treatment 0.36 0.00858 0.44 0.35 -3.75E-4 -0.02 0.2942 0.6697 1673550 Bionet1_003494 COc1ccc(OC)c(c1)n2c(C)ccc2c3ccc(cc3)S(=O)(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K17 compound treatment 0.344 -0.00742 -0.38 0.34 -0.0104 -0.63 -0.7111 -0.9711 1910204 Bionet1_003495 CC(C)(C)c1cc(C#N)c(OC(=O)c2ccc(cc2)C(F)(F)F)c(C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K18 compound treatment 0.347 -0.00442 -0.23 0.345 -0.00538 -0.32 -0.3892 -0.9844 1910205 Bionet1_003496 Cc1ccc(Sc2nc(cc(c2C#N)C(F)(F)F)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K19 compound treatment 0.35 -0.00142 -0.07 0.345 -0.00538 -0.32 -0.2808 -0.8444 1910206 Bionet1_003497 Clc1ncc(COc2ccccc2/C=N/NC(=O)c3cccnc3)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K20 compound treatment 0.343 -0.00842 -0.43 0.35 -3.75E-4 -0.02 -0.3204 -0.7433 1588099 Bionet1_003498 COC(=O)c1cc(C#N)c(NCc2cc(no2)c3ccc(OC)cc3)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K21 compound treatment 0.34 -0.0114 -0.58 0.34 -0.0104 -0.63 -0.8558 -0.9994 1910207 Bionet1_003499 FC(F)(F)c1ccc(cc1)C(=O)N/N=C/c2ccccc2Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K22 compound treatment 0.349 -0.00242 -0.12 0.351 6.25E-4 0.04 -0.0608 -0.4701 1910208 Bionet1_003500 CC(=O)c1cc(C#N)c(NCc2cc(no2)c3ccc(Cl)cc3)nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K23 positive control 0.087 -0.264 -13.52 0.088 -0.262 -15.84 -20.7603 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 K24 positive control 0.095 -0.256 -13.11 0.094 -0.256 -15.48 -20.215 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L01 mock treatment 0.352 5.81E-4 0.03 0.349 -0.00138 -0.08 -0.0377 -0.4277 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L02 mock treatment 0.353 0.00158 0.08 0.357 0.00662 0.4 0.34 0.8332 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L03 compound treatment 0.356 0.00458 0.23 0.353 0.00262 0.16 0.2777 0.9819 1910209 Bionet1_003501 Fc1ccc(cc1)c2n[nH]cc2/C=N\OCc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L04 compound treatment 0.351 -4.19E-4 -0.02 0.36 0.00962 0.58 0.3957 0.6805 1910210 Bionet1_003502 COC(=O)c1sccc1Oc2nc(SC)nc3n(ncc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L05 compound treatment 0.177 -0.174 -8.92 0.147 -0.203 -12.28 -14.9878 -0.9877 1910211 Bionet1_003503 COC(=O)c1ccc(/N=C/c2cnc(s2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L06 compound treatment 0.399 0.0476 2.43 0.377 0.0266 1.61 2.8569 0.9798 1910212 Bionet1_003504 Cc1ccc2SCc3cnc(SCc4ccc(F)cc4)nc3-c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L07 compound treatment 0.402 0.0506 2.59 0.359 0.00862 0.52 2.197 0.8328 1910213 Bionet1_003505 Fc1ccc(cc1)c2n[nH]cc2/C=N\Nc3ccnc4cc(Cl)ccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L08 compound treatment 0.376 0.0246 1.26 0.372 0.0216 1.31 1.8118 0.9998 1910214 Bionet1_003506 Cc1ccc2SCc3cnc(SCc4c(F)cccc4Cl)nc3-c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L09 compound treatment 0.35 -0.00142 -0.07 0.354 0.00362 0.22 0.1034 0.4486 1910215 Bionet1_003507 CN(C)/C=C/C(=O)C(Cc1c(Cl)cccc1Cl)C(=O)/C=C\N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L10 compound treatment 0.361 0.00958 0.49 0.356 0.00562 0.34 0.5865 0.984 1579848 Bionet1_003508 Cc1ccc(cc1)S(=O)(=O)c2cnc(nc2N3CCOCC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L11 compound treatment 0.347 -0.00442 -0.23 0.353 0.00262 0.16 -0.0477 -0.1729 1910216 Bionet1_003509 CN(C)/C=C/C(=O)C(Cc1c(F)cccc1Cl)C(=O)/C=C\N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L12 compound treatment 0.339 -0.0124 -0.64 0.347 -0.00338 -0.2 -0.5931 -0.8893 1664188 Bionet1_003510 CCN(CC)c1nc(ncc1S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L13 compound treatment 0.362 0.0106 0.54 0.356 0.00562 0.34 0.6227 0.9748 1542564 Bionet1_003511 Cc1ccccc1OCC2Cc3c(O2)nc(c(C#N)c3n4cccc4)n5cccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L14 compound treatment 0.348 -0.00342 -0.17 0.349 -0.00138 -0.08 -0.1823 -0.942 1910217 Bionet1_003512 CSc1nc(Oc2ccc3ccccc3c2)c4cnn(c5ccc(C)cc5)c4n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L15 compound treatment 0.345 -0.00642 -0.33 0.353 0.00262 0.16 -0.12 -0.3294 1494141 Bionet1_003513 CC(CO)Oc1ccc(cc1)c2ccc(c(F)c2)c3ccc(OC(C)CO)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L16 compound treatment 0.348 -0.00342 -0.17 0.347 -0.00338 -0.2 -0.2677 -0.9971 1566962 Bionet1_003514 COc1cc2ncnc(Nc3ccc(Br)cc3)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L17 compound treatment 0.36 0.00858 0.44 0.334 -0.0164 -0.99 -0.3888 -0.3595 1011790 Bionet1_003515 CCCCCCCCCCCCCCCCCC[n+]1ccccc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L18 compound treatment 0.362 0.0106 0.54 0.364 0.0136 0.82 0.9642 0.9793 1277018 Bionet1_003516 COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L19 compound treatment 0.221 -0.13 -6.67 0.216 -0.134 -8.11 -10.4515 -0.9953 1910218 Bionet1_003517 CS(=O)(=O)/C(=C\c1cnc(s1)S(=O)(=O)c2ccccc2)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L20 compound treatment 0.362 0.0106 0.54 0.351 6.25E-4 0.04 0.4092 0.7546 1473188 Bionet1_003518 COc1cc2ncnc(Nc3ccc(Cl)cc3Cl)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L21 compound treatment 0.35 -0.00142 -0.07 0.352 0.00162 0.1 0.018 0.1479 1910219 Bionet1_003519 FC(=C(F)CCSc1nc2nccc(c3ccc(F)cc3)n2n1)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L22 compound treatment 0.356 0.00458 0.23 0.356 0.00562 0.34 0.4057 0.9836 1603939 Bionet1_003520 COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L23 positive control 0.088 -0.263 -13.47 0.087 -0.263 -15.9 -20.7669 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 L24 positive control 0.098 -0.253 -12.96 0.092 -0.258 -15.6 -20.1919 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M01 mock treatment 0.357 0.00558 0.29 0.357 0.00662 0.4 0.4846 0.9863 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M02 mock treatment 0.357 0.00558 0.29 0.358 0.00762 0.46 0.5273 0.9736 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M03 compound treatment 0.354 0.00258 0.13 0.355 0.00462 0.28 0.2907 0.9414 1910220 Bionet1_003521 Cc1ccc(Oc2ccccc2/C=N/NC(=O)c3ccc(cc3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M04 compound treatment 0.36 0.00858 0.44 0.32 -0.0304 -1.83 -0.9864 -0.5231 1910221 Bionet1_003522 CN(CC(=O)NCc1cc(no1)c2ccc(Cl)cc2)Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M05 compound treatment 0.381 0.0296 1.51 0.359 0.00862 0.52 1.4377 0.8988 1910222 Bionet1_003523 Oc1ccn(Nc2ncccc2[N+](=O)[O-])c(=O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M06 compound treatment 0.345 -0.00642 -0.33 0.341 -0.00937 -0.57 -0.6323 -0.9664 1910223 Bionet1_003524 Cc1cc(Sc2cccc(c2)C(F)(F)F)nc3ccc(Cl)cc13 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M07 compound treatment 0.354 0.00258 0.13 0.358 0.00762 0.46 0.4188 0.8746 1910224 Bionet1_003525 CSc1nc(N(C)NC(=O)c2ccc(Cl)cc2)c3ccccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M08 compound treatment 0.369 0.0176 0.9 0.368 0.0176 1.06 1.388 0.9965 1375673 Bionet1_003526 Cc1ccc(cc1)n2nc(cc2c3ccc(Cl)cc3)C(=O)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M09 compound treatment 0.352 5.81E-4 0.03 0.351 6.25E-4 0.04 0.0477 0.993 1910225 Bionet1_003527 CSc1nc(Sc2cc(Cl)ccc2Cl)c3ccccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M10 compound treatment 0.342 -0.00942 -0.48 0.34 -0.0104 -0.63 -0.7834 -0.9916 1910226 Bionet1_003528 Clc1ccccc1c2cc(on2)C(=O)NCc3cc(no3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M11 compound treatment 0.353 0.00158 0.08 0.35 -3.75E-4 -0.02 0.0411 0.4902 1910227 Bionet1_003529 CSc1nc(Sc2ccc(Cl)cc2Cl)c3ccccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M12 compound treatment 0.376 0.0246 1.26 0.374 0.0236 1.43 1.8972 0.998 1910228 Bionet1_003530 COc1cccc(c1)C(=O)Nc2ccc(/C=C/c3nc4ccccc4o3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M13 compound treatment 0.349 -0.00242 -0.12 0.346 -0.00438 -0.26 -0.2742 -0.9403 1910229 Bionet1_003531 CSc1nc(Oc2cc(Cl)c(Cl)cc2Cl)c3ccccc3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M14 compound treatment 0.368 0.0166 0.85 0.366 0.0156 0.94 1.2665 0.9986 1910230 Bionet1_003532 Fc1cccc(F)c1C(=O)Nc2ccc(/C=C/c3nc4ccccc4o3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M15 compound treatment 0.354 0.00258 0.13 0.329 -0.0214 -1.29 -0.8191 -0.6315 1910231 Bionet1_003533 CSc1nc(Oc2cc(Cl)c(Cl)cc2Cl)cc(n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M16 compound treatment 0.349 -0.00242 -0.12 0.347 -0.00338 -0.2 -0.2315 -0.9714 1370465 Bionet1_003534 Fc1ccc(cc1)S(=O)(=O)N2C(COc3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M17 compound treatment 0.352 5.81E-4 0.03 0.356 0.00562 0.34 0.2611 0.766 1910232 Bionet1_003535 COc1ccc(CCOC(=O)Nc2cn(C)nc2C(F)(F)F)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M18 compound treatment 0.351 -4.19E-4 -0.02 0.346 -0.00438 -0.26 -0.2019 -0.762 1680960 Bionet1_003536 Cc1ccc(cc1)S(=O)(=O)N2C(COc3ccc(C)cc23)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M19 compound treatment 0.35 -0.00142 -0.07 0.335 -0.0154 -0.93 -0.7076 -0.7601 1728119 Bionet1_003537 CC1COc2ccccc2N1S(=O)(=O)c3cc(Cl)ccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M20 compound treatment 0.344 -0.00742 -0.38 0.336 -0.0144 -0.87 -0.8819 -0.9311 1518407 Bionet1_003538 Cc1ccc2OCC(N(c2c1)S(=O)(=O)c3ccc(F)cc3)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M21 compound treatment 0.347 -0.00442 -0.23 0.343 -0.00737 -0.45 -0.4746 -0.9506 1615505 Bionet1_003539 COc1ccc(cc1)S(=O)(=O)N2C(COc3ccccc23)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M22 compound treatment 0.355 0.00358 0.18 0.358 0.00762 0.46 0.4549 0.9184 1585848 Bionet1_003540 COc1ccc(Oc2c(Cl)cnn(c3ccc(Cl)c(Cl)c3)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M23 positive control 0.088 -0.263 -13.47 0.087 -0.263 -15.9 -20.7669 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 M24 positive control 0.095 -0.256 -13.11 0.094 -0.256 -15.48 -20.215 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N01 mock treatment 0.35 -0.00142 -0.07 0.349 -0.00138 -0.08 -0.11 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N02 mock treatment 0.363 0.0116 0.59 0.353 0.00262 0.16 0.5308 0.8659 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N03 compound treatment 0.353 0.00158 0.08 0.347 -0.00338 -0.2 -0.0869 -0.3965 1910233 Bionet1_003541 FC(F)(F)c1cccc(c1)N2CCN(CC(=O)c3cccs3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N04 compound treatment 0.353 0.00158 0.08 0.355 0.00462 0.28 0.2546 0.8758 1303887 Bionet1_003542 COc1cc2ncnc(Nc3ccc(cc3)N4CCOCC4)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N05 compound treatment 0.353 0.00158 0.08 0.356 0.00562 0.34 0.2973 0.8516 1910234 Bionet1_003543 COc1ccc(cc1)C2=NN(C(C2)c3ccc(Cl)cc3)c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N06 compound treatment 0.373 0.0216 1.1 0.373 0.0226 1.37 1.7461 0.9944 1412837 Bionet1_003544 COc1cc2ncnc(NCc3ccc(Cl)cc3Cl)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N07 compound treatment 0.384 0.0326 1.67 0.385 0.0346 2.09 2.656 0.9937 1910235 Bionet1_003545 Fc1ccc(N2N=C(CC2c3ccccc3)c4ccc(Cl)cc4)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N08 compound treatment 0.353 0.00158 0.08 0.353 0.00262 0.16 0.1692 0.9512 1910236 Bionet1_003546 COc1cc2ncnc(NCc3ccccc3C(F)(F)F)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N09 compound treatment 0.381 0.0296 1.51 0.383 0.0326 1.97 2.4622 0.9915 1910237 Bionet1_003547 CC(=O)Nc1ccc(cc1)C2CC(=NN2c3ccccc3)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N10 compound treatment 0.359 0.00758 0.39 0.361 0.0106 0.64 0.7276 0.9709 1736243 Bionet1_003548 Clc1ccc2c(Nc3ccc(I)cc3)ncnc2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N11 compound treatment 0.398 0.0466 2.38 0.405 0.0546 3.3 4.0159 0.9872 1910238 Bionet1_003549 COc1cccc(c1)C2=NN(C(C2)c3ccc(Cl)cc3)c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N12 compound treatment 0.366 0.0146 0.75 0.36 0.00962 0.58 0.938 0.9924 1284145 Bionet1_003550 COc1cc2ncnc(NCc3ccc(Cl)c(Cl)c3)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N13 compound treatment 0.357 0.00558 0.29 0.351 6.25E-4 0.04 0.2285 0.7937 1910239 Bionet1_003551 COc1ccc(cc1)c2cnc3nc(SCCC(=C(F)F)F)nn3c2N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N14 compound treatment 0.358 0.00658 0.34 0.357 0.00662 0.4 0.5207 0.9963 1646584 Bionet1_003552 COc1ccc(CNc2ncnc3cc(OC)c(OC)cc23)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N15 compound treatment 0.369 0.0176 0.9 0.369 0.0186 1.12 1.4307 0.9939 1910240 Bionet1_003553 FC(=C(F)CCSc1nc2nccc(/C=C\c3cccs3)n2n1)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N16 compound treatment 0.355 0.00358 0.18 0.36 0.00962 0.58 0.5403 0.8869 1910241 Bionet1_003554 COc1cc2ncnc(NCc3cccc(c3)C(F)(F)F)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N17 compound treatment 0.367 0.0156 0.8 0.364 0.0136 0.82 1.1449 0.9999 1463826 Bionet1_003555 Cc1ccc(cc1)C2CN(CC2C(=O)c3ccc(F)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N18 compound treatment 0.358 0.00658 0.34 0.354 0.00362 0.22 0.3927 0.9783 1631243 Bionet1_003556 COc1ccc(CCNc2ncnc3cc(OC)c(OC)cc23)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N19 compound treatment 0.357 0.00558 0.29 0.349 -0.00138 -0.08 0.1431 0.4815 1127217 Bionet1_003557 Clc1ccc(cc1)C2CN(CC2C(=O)c3cccs3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N20 compound treatment 0.342 -0.00942 -0.48 0.351 6.25E-4 0.04 -0.3139 -0.6497 1398126 Bionet1_003558 COc1cc2ncnc(NCCc3ccc(cc3)S(=O)(=O)N)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N21 compound treatment 0.347 -0.00442 -0.23 0.34 -0.0104 -0.63 -0.6027 -0.9051 1910242 Bionet1_003559 COc1ccc(NC(=O)c2ccccc2SCCC(=C(F)F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N22 compound treatment 0.347 -0.00442 -0.23 0.353 0.00262 0.16 -0.0477 -0.1729 1910243 Bionet1_003560 Clc1ccc(SCCNc2ncnc3cc(Cl)ccc23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N23 positive control 0.089 -0.262 -13.42 0.088 -0.262 -15.84 -20.688 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 N24 positive control 0.093 -0.258 -13.21 0.094 -0.256 -15.48 -20.2873 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O01 mock treatment 0.362 0.0106 0.54 0.357 0.00662 0.4 0.6654 0.9889 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O02 mock treatment 0.363 0.0116 0.59 0.361 0.0106 0.64 0.8723 0.9992 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O03 compound treatment 0.358 0.00658 0.34 0.353 0.00262 0.16 0.35 0.941 1353850 Bionet1_003561 CC(C)(C)C1COc2ccccc2N1S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O04 compound treatment 0.361 0.00958 0.49 0.357 0.00662 0.4 0.6292 0.9949 1435481 Bionet1_003562 COc1ccc(Oc2c(cnn(c3ccc(C)cc3)c2=O)N4CCOCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O05 compound treatment 0.349 -0.00242 -0.12 0.35 -3.75E-4 -0.02 -0.1035 -0.8228 1333895 Bionet1_003563 Clc1ccc(cc1)S(=O)(=O)N2C(COc3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O06 compound treatment 0.357 0.00558 0.29 0.347 -0.00338 -0.2 0.0577 0.1646 1364036 Bionet1_003564 COc1ccc(Oc2c(Cl)cnn(c3cccc(C)c3C)c2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O07 compound treatment 0.36 0.00858 0.44 0.366 0.0156 0.94 0.9772 0.9394 1147999 Bionet1_003565 COc1ccc(cc1)S(=O)(=O)N2C(COc3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O08 compound treatment 0.359 0.00758 0.39 0.351 6.25E-4 0.04 0.3008 0.7723 1910244 Bionet1_003566 FC(F)(F)c1cc(nc(N2CCOCC2)c1C#N)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O09 compound treatment 0.359 0.00758 0.39 0.358 0.00762 0.46 0.5996 0.9963 1910245 Bionet1_003567 Cn1nc(OCC(O)CS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O10 compound treatment 0.352 5.81E-4 0.03 0.35 -3.75E-4 -0.02 0.005 0.1336 1910246 Bionet1_003568 COC(=O)c1ccccc1Sc2nc(C)cc(c2C#N)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O11 compound treatment 0.35 -0.00142 -0.07 0.35 -3.75E-4 -0.02 -0.0673 -0.8856 1510173 Bionet1_003569 CN1CCN(CC1)c2cnn(c3ccc(F)cc3)c(=O)c2Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O12 compound treatment 0.368 0.0166 0.85 0.37 0.0196 1.18 1.4372 0.9865 1458590 Bionet1_003570 COc1ccc(cc1)C2C(CN3CCOCC3)C(=O)N2c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O13 compound treatment 0.343 -0.00842 -0.43 0.345 -0.00538 -0.32 -0.5339 -0.9903 1515952 Bionet1_003571 CN(Cc1ccccc1)c2cnn(c3ccc(F)cc3)c(=O)c2Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O14 compound treatment 0.393 0.0416 2.13 0.402 0.0516 3.12 3.7071 0.9826 1910247 Bionet1_003572 COc1cccc(c1)C(=O)Nc2ccc(/C=C/c3nc4ccccc4s3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O15 compound treatment 0.358 0.00658 0.34 0.358 0.00762 0.46 0.5634 0.9881 1248744 Bionet1_003573 OCc1cnc(n1Cc2ccccc2)S(=O)(=O)Cc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O16 compound treatment 0.354 0.00258 0.13 0.348 -0.00238 -0.14 -0.0081 -0.0414 1698392 Bionet1_003574 CCS(=O)(=O)c1ccc(c2csc(n2)c3ccccc3)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O17 compound treatment 0.378 0.0266 1.36 0.385 0.0346 2.09 2.4391 0.9783 1910248 Bionet1_003575 Clc1ccc(cc1)c2cc(CS(=O)(=O)c3cccc(Cl)c3)on2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O18 compound treatment 0.357 0.00558 0.29 0.351 6.25E-4 0.04 0.2285 0.7937 1388552 Bionet1_003576 CCS(=O)(=O)c1ccc(c2csc(n2)c3ccccn3)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O19 compound treatment 0.348 -0.00342 -0.17 0.346 -0.00438 -0.26 -0.3104 -0.9799 1654004 Bionet1_003577 CC(C)(C)c1ccc(CN2C(=O)CCSc3ccc(Cl)cc23)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O20 compound treatment 0.364 0.0126 0.64 0.355 0.00462 0.28 0.6523 0.9302 1329709 Bionet1_003578 CCS(=O)(=O)c1ccc(c2csc(n2)c3ccncc3)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O21 compound treatment 0.352 5.81E-4 0.03 0.342 -0.00837 -0.51 -0.3365 -0.6644 1910249 Bionet1_003579 Clc1ccc2SCCC(=O)N(Cc3ccc(Cl)c(Cl)c3)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O22 compound treatment 0.351 -4.19E-4 -0.02 0.351 6.25E-4 0.04 0.0115 0.2654 1910250 Bionet1_003580 Cc1ccc(cc1)n2ncc(Cl)c(Sc3ccc(Cl)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O23 positive control 0.091 -0.26 -13.32 0.088 -0.262 -15.84 -20.6157 -0.9963 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 O24 positive control 0.094 -0.257 -13.16 0.093 -0.257 -15.54 -20.2938 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P01 mock treatment 0.36 0.00858 0.44 0.36 0.00962 0.58 0.7211 0.9904 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P02 mock treatment 0.363 0.0116 0.59 0.359 0.00862 0.52 0.7869 0.9979 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P03 compound treatment 0.36 0.00858 0.44 0.361 0.0106 0.64 0.7638 0.9828 1910251 Bionet1_003581 FC(=C(F)CCSc1ncn(n1)c2ncc(cc2Cl)C(F)(F)F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P04 compound treatment 0.355 0.00358 0.18 0.366 0.0156 0.94 0.7964 0.8289 1440383 Bionet1_003582 OC(CNc1ncnc2cc(Cl)ccc12)c3ccc4ccccc4c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P05 compound treatment 0.353 0.00158 0.08 0.353 0.00262 0.16 0.1692 0.9512 1910252 Bionet1_003583 FC(=C(F)CCSc1ncccc1C(=O)NC2CCCCCCC2)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P06 compound treatment 0.368 0.0166 0.85 0.361 0.0106 0.64 1.053 0.9905 1910253 Bionet1_003584 Cc1ccc(CSC/2=Nc3ccccc3\C2=N/Nc4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P07 compound treatment 0.346 -0.00542 -0.28 0.357 0.00662 0.4 0.0869 0.1785 1295777 Bionet1_003585 CCOC(=O)c1c2ccc(OCc3ccc(C)cc3)cc2n4ccccc14 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P08 compound treatment 0.359 0.00758 0.39 0.349 -0.00138 -0.08 0.2154 0.5434 1910254 Bionet1_003586 N#Cc1cc(oc1/N=C/c2ccc(Oc3ccccc3)cc2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P09 compound treatment 0.348 -0.00342 -0.17 0.345 -0.00538 -0.32 -0.3531 -0.9579 1436818 Bionet1_003587 COc1ccc2ccccc2c1S(=O)N3CCN(Cc4ccccc4)CC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P10 compound treatment 0.394 0.0426 2.18 0.387 0.0366 2.21 3.103 1.0 1910255 Bionet1_003588 Brc1ccc(/C=N/c2oc(cc2C#N)c3ccccc3)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P11 compound treatment 0.351 -4.19E-4 -0.02 0.34 -0.0104 -0.63 -0.458 -0.7309 1910256 Bionet1_003589 COc1ccc2ccccc2c1S(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P12 compound treatment 0.351 -4.19E-4 -0.02 0.35 -3.75E-4 -0.02 -0.0312 -0.9996 1910257 Bionet1_003590 FC(F)(F)c1ccccc1C(=O)Nc2oc(cc2C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P13 compound treatment 0.322 -0.0294 -1.5 0.326 -0.0244 -1.47 -2.1042 -0.9999 1147892 Bionet1_003591 COc1ccc2ccccc2c1S(=O)N3CCN(CC3)c4ccccc4F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P14 compound treatment 0.34 -0.0114 -0.58 0.341 -0.00937 -0.57 -0.8131 -0.9999 1910258 Bionet1_003592 Cc1ccc(cc1)S(=O)(=O)NNC(=O)c2cc3CCc4ccccc4-c3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P15 compound treatment 0.313 -0.0384 -1.96 0.323 -0.0274 -1.65 -2.5576 -0.9963 1521904 Bionet1_003593 COc1ccc2ccccc2c1S(=O)N3CCN(CC3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P16 compound treatment 0.363 0.0116 0.59 0.357 0.00662 0.4 0.7015 0.9817 1910259 Bionet1_003594 Clc1ccc(/C=N/NC(=O)c2cc3CCc4ccccc4-c3s2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P17 compound treatment 0.357 0.00558 0.29 0.355 0.00462 0.28 0.3992 0.9999 1237317 Bionet1_003595 CCOC(=O)c1c2ccc(OCc3c(F)cccc3Cl)cc2n4ccccc14 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P18 compound treatment 0.343 -0.00842 -0.43 0.351 6.25E-4 0.04 -0.2777 -0.6427 1910260 Bionet1_003596 FC(F)(F)c1cccc(/C=N/NC(=O)c2cc3CCc4ccccc4-c3s2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P19 compound treatment 0.349 -0.00242 -0.12 0.349 -0.00138 -0.08 -0.1462 -0.9812 1910261 Bionet1_003597 FC(=C(F)CCSc1ncccc1C(=O)NCc2ccccc2)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P20 compound treatment 0.352 5.81E-4 0.03 0.363 0.0126 0.76 0.5599 0.7341 1910262 Bionet1_003598 Fc1ccc(/C=N/NC(=O)c2cc3CCc4ccccc4-c3s2)cc1F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P21 compound treatment 0.356 0.00458 0.23 0.351 6.25E-4 0.04 0.1923 0.8106 1667164 Bionet1_003599 COC(=O)c1sccc1NC(=O)COc2ccsc2C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P22 compound treatment 0.35 -0.00142 -0.07 0.35 -3.75E-4 -0.02 -0.0673 -0.8856 1446805 Bionet1_003600 COc1ccc(cc1)S(=O)(=O)N2CCN(CC2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P23 positive control 0.09 -0.261 -13.37 0.089 -0.261 -15.78 -20.6092 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.578 P24 positive control 0.095 -0.256 -13.11 0.094 -0.256 -15.48 -20.215 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A01 mock treatment 0.322 -0.0288 -1.47 0.324 -0.0353 -2.13 -2.5445 -0.9837 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A02 mock treatment 0.323 -0.0278 -1.42 0.329 -0.0303 -1.83 -2.295 -0.9922 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A03 compound treatment 0.328 -0.0227 -1.16 0.332 -0.0273 -1.65 -1.9861 -0.9856 1376399 Bionet1_003601 Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A04 compound treatment 0.334 -0.0168 -0.86 0.33 -0.0293 -1.77 -1.8545 -0.9448 1910263 Bionet1_003602 FC(F)(F)c1cccc(c1)N2CCN(Cc3cnc(Cl)s3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A05 compound treatment 0.329 -0.0217 -1.11 0.335 -0.0243 -1.46 -1.8219 -0.9908 1183828 Bionet1_003603 Clc1ccc(Cl)c(c1)S(=O)(=O)N2CCN(CC2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A06 compound treatment 0.4 0.0493 2.52 0.411 0.0517 3.12 3.9894 0.9943 1910264 Bionet1_003604 COc1cc(Br)c(O)c(/C=N/Cc2ccc3OCOc3c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A07 compound treatment 0.329 -0.0217 -1.11 0.331 -0.0283 -1.71 -1.9926 -0.9785 1910265 Bionet1_003605 FC(F)(F)c1ccccc1C(=O)N2CCN(CC2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A08 compound treatment 0.408 0.0573 2.93 0.416 0.0567 3.43 4.4921 0.9969 1910266 Bionet1_003606 COc1cc(Br)c(O)c(/C=N/c2ccc(cc2)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A09 compound treatment 0.321 -0.0297 -1.52 0.327 -0.0323 -1.95 -2.4526 -0.9925 1910267 Bionet1_003607 FC(F)(F)c1ccccc1S(=O)(=O)N2CCN(CC2)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A10 compound treatment 0.381 0.0302 1.55 0.385 0.0257 1.55 2.1926 1.0 1910268 Bionet1_003608 COc1cc(Br)cc(/C=N/c2cccc(Br)c2)c1O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A11 compound treatment 0.353 0.00225 0.12 0.364 0.00474 0.29 0.2838 0.9198 1350151 Bionet1_003609 Clc1cccc(C(=O)Nc2oc(cc2C#N)c3ccccc3)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A12 compound treatment 0.331 -0.0198 -1.01 0.337 -0.0223 -1.34 -1.6642 -0.9901 1910269 Bionet1_003610 COc1cc(OC)cc(/N=C/c2cc(Br)cc(OC)c2O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A13 compound treatment 0.338 -0.0127 -0.65 0.34 -0.0193 -1.16 -1.2831 -0.9626 1910270 Bionet1_003611 FC(F)(F)c1cccc(CSc2nc(ccc2C#N)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A14 compound treatment 0.373 0.0222 1.14 0.38 0.0207 1.25 1.6899 0.9989 1910271 Bionet1_003612 COC(=O)c1cccc(/N=C/c2cc(Br)cc(OC)c2O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A15 compound treatment 0.333 -0.0177 -0.91 0.335 -0.0243 -1.46 -1.6773 -0.9735 1289590 Bionet1_003613 Clc1cccc(C(=O)N2CCN(CC2)C(=O)c3ccccc3)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A16 compound treatment 0.392 0.0413 2.11 0.399 0.0397 2.4 3.1879 0.9979 1910272 Bionet1_003614 COc1cc(Br)c(O)c(/C=N/Cc2ccc(OC)c(OC)c2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A17 compound treatment 0.329 -0.0217 -1.11 0.34 -0.0193 -1.16 -1.6085 -0.9998 1201217 Bionet1_003615 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A18 compound treatment 0.361 0.0103 0.52 0.382 0.0227 1.37 1.3414 0.9128 1910273 Bionet1_003616 Oc1c(Br)cc(Br)cc1/C=N/Cc2ccc(F)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A19 compound treatment 0.329 -0.0217 -1.11 0.324 -0.0353 -2.13 -2.2915 -0.9542 1213082 Bionet1_003617 COc1cc2ncnc(NCC(O)c3ccc4ccccc4c3)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A20 compound treatment 0.325 -0.0257 -1.32 0.333 -0.0263 -1.59 -2.0519 -0.9957 1489756 Bionet1_003618 CN1OC(CC(=O)NCc2ccc(F)cc2)N(C1=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A21 compound treatment 0.323 -0.0278 -1.42 0.33 -0.0293 -1.77 -2.2523 -0.9941 1910274 Bionet1_003619 CCOC(=O)c1ccc(/N=C/c2ccccc2Oc3ccc(F)c(F)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A22 compound treatment 0.322 -0.0288 -1.47 0.331 -0.0283 -1.71 -2.2457 -0.9973 1910275 Bionet1_003620 FC(F)(F)c1ccc2[nH]cc(c3ncc(cc3Cl)C(F)(F)F)c(=O)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A23 positive control 0.085 -0.266 -13.59 0.086 -0.273 -16.5 -21.273 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 A24 positive control 0.087 -0.264 -13.49 0.09 -0.269 -16.25 -21.0299 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B01 mock treatment 0.347 -0.00375 -0.19 0.35 -0.00926 -0.56 -0.5308 -0.8983 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B02 mock treatment 0.352 0.00125 0.06 0.358 -0.00126 -0.08 -0.0085 -0.0857 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B03 compound treatment 0.361 0.0103 0.52 0.361 0.00174 0.11 0.445 0.8324 1910276 Bionet1_003621 Cc1ccc(CSc2nnc(o2)c3cc4CCc5ccccc5-c4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B04 compound treatment 0.467 0.116 5.94 0.447 0.0877 5.3 7.9486 0.9983 1910277 Bionet1_003622 CCOC(=O)/C(=N\Nc1ccccc1[N+](=O)[O-])/NC(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B05 compound treatment 0.399 0.0483 2.47 0.36 7.42E-4 0.04 1.7762 0.7198 1910278 Bionet1_003623 CCOC(=O)c1cnc2ccc(OC)cc2c1Nc3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B06 compound treatment 0.338 -0.0127 -0.65 0.345 -0.0143 -0.86 -1.0696 -0.9906 1910279 Bionet1_003624 Cc1ccc(cc1)C(=O)Oc2ccc(cc2)c3nccc(n3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B07 compound treatment 0.385 0.0343 1.75 0.377 0.0177 1.07 1.9957 0.9722 1247702 Bionet1_003625 CCOC(=O)c1cnc2ccc(OC)cc2c1Nc3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B08 compound treatment 0.354 0.00325 0.17 0.355 -0.00426 -0.26 -0.0643 -0.2099 1910280 Bionet1_003626 Fc1ccc(cc1)C(=O)Oc2ccc(cc2)c3nccc(n3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B09 compound treatment 0.357 0.00625 0.32 0.356 -0.00326 -0.2 0.0869 0.2316 1910281 Bionet1_003627 Clc1ccc(cc1)C(=O)ON=C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B10 compound treatment 0.383 0.0323 1.65 0.374 0.0147 0.89 1.7953 0.9581 1739750 Bionet1_003628 O=C(Cc1ccccc1)Oc2ccc(cc2)c3nccc(n3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B11 compound treatment 0.354 0.00325 0.17 0.357 -0.00226 -0.14 0.0211 0.0982 1910282 Bionet1_003629 Fc1ccc(cc1)C(=O)ON=C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B12 compound treatment 0.356 0.00525 0.27 0.356 -0.00326 -0.2 0.0507 0.1525 1910283 Bionet1_003630 Clc1ccc(cc1)C(=O)Oc2ccc(cc2)c3nccc(n3)c4ccccn4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B13 compound treatment 0.356 0.00525 0.27 0.358 -0.00126 -0.08 0.1361 0.4879 1910284 Bionet1_003631 Cc1ccc(cc1)C(=O)ON=C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B14 compound treatment 0.361 0.0103 0.52 0.363 0.00374 0.23 0.5303 0.9292 1910285 Bionet1_003632 CCCCCCCCS(=O)(=O)c1nnc(o1)c2ccc(OC)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B15 compound treatment 0.359 0.00825 0.42 0.355 -0.00426 -0.26 0.1165 0.2359 1910286 Bionet1_003633 Clc1cccc(c1)C(=O)ON=C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B16 compound treatment 0.369 0.0182 0.93 0.367 0.00774 0.47 0.9903 0.9489 1910287 Bionet1_003634 O=S(=O)(Oc1ccc(cc1)c2nccc(n2)c3ccccn3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B17 compound treatment 0.358 0.00725 0.37 0.362 0.00274 0.17 0.3792 0.934 1910288 Bionet1_003635 O=C(ON=C1CCN(CC1)S(=O)(=O)c2ccccc2)c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B18 compound treatment 0.357 0.00625 0.32 0.361 0.00174 0.11 0.3003 0.8927 1910289 Bionet1_003636 CC(C)(C)c1ccc(cc1)c2nnc(SCc3ccc(cc3)[N+](=O)[O-])o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B19 compound treatment 0.358 0.00725 0.37 0.354 -0.00526 -0.32 0.0377 0.0772 1910290 Bionet1_003637 O=S(=O)(ON=C1CCN(CC1)S(=O)(=O)c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B20 compound treatment 0.346 -0.00475 -0.24 0.347 -0.0123 -0.74 -0.695 -0.8924 1910291 Bionet1_003638 CC(C)(C)c1ccc(cc1)c2nnc(SCc3ccc(Cl)cc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B21 compound treatment 0.361 0.0103 0.52 0.366 0.00674 0.41 0.6584 0.9922 1910292 Bionet1_003639 Cc1ccn2c(/C=C(\C#N)/c3ccccn3)c(nc2c1)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B22 compound treatment 0.351 2.5E-4 0.01 0.354 -0.00526 -0.32 -0.2154 -0.6781 1910293 Bionet1_003640 Fc1cccc(Cl)c1COc2ccc(C=C3C(=O)NC(=O)NC3=O)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B23 positive control 0.088 -0.263 -13.44 0.091 -0.268 -16.19 -20.9511 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 B24 positive control 0.088 -0.263 -13.44 0.091 -0.268 -16.19 -20.9511 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C01 mock treatment 0.346 -0.00475 -0.24 0.351 -0.00826 -0.5 -0.5243 -0.9454 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C02 mock treatment 0.354 0.00325 0.17 0.36 7.42E-4 0.04 0.1492 0.8668 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C03 compound treatment 0.358 0.00725 0.37 0.371 0.0117 0.71 0.7634 0.9543 1217132 Bionet1_003641 CCOC(=O)c1ccc(NCc2ccccc2Oc3ccc(F)c(F)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C04 compound treatment 0.361 0.0103 0.52 0.368 0.00874 0.53 0.7438 1.0 1910294 Bionet1_003642 Fc1ccc(F)c2c(=O)c(c[nH]c12)c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C05 compound treatment 0.369 0.0182 0.93 0.376 0.0167 1.01 1.3745 0.9992 1910295 Bionet1_003643 FC(F)(F)c1cnc(CC(=O)NCc2ccc(Cl)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C06 compound treatment 0.363 0.0123 0.63 0.368 0.00874 0.53 0.8161 0.9964 1664882 Bionet1_003644 CN1OC(CC(=O)NCc2ccc(C)cc2)N(C1=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C07 compound treatment 0.35 -7.5E-4 -0.04 0.351 -0.00826 -0.5 -0.3796 -0.7593 1910296 Bionet1_003645 Cc1cccc(n1)n2cnc(c2)C(=O)N/N=C\c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C08 compound treatment 0.35 -7.5E-4 -0.04 0.357 -0.00226 -0.14 -0.1235 -0.8722 1910297 Bionet1_003646 Oc1ccn(CCc2c[nH]c3ccccc23)c(=O)c1C/C=C/c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C09 compound treatment 0.346 -0.00475 -0.24 0.355 -0.00426 -0.26 -0.3535 -0.9996 1910298 Bionet1_003647 COc1ccc(cc1)S(=O)(=O)NNC(=O)c2cn(cn2)c3cccc(C)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C10 compound treatment 0.379 0.0283 1.44 0.386 0.0267 1.61 2.1629 0.9985 1910299 Bionet1_003648 Cc1ccc(cc1)C(C#N)c2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C11 compound treatment 0.368 0.0173 0.88 0.371 0.0117 0.71 1.1249 0.9941 1910300 Bionet1_003649 COc1cc(/C=N/NC(=O)c2cn(cn2)c3cccc(C)n3)ccc1O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C12 compound treatment 0.388 0.0372 1.9 0.388 0.0287 1.74 2.5737 0.9989 1910301 Bionet1_003650 Fc1ccc(cc1)C(C#N)c2ccc3c(cc(nc3n2)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C13 compound treatment 0.337 -0.0138 -0.7 0.35 -0.00926 -0.56 -0.8923 -0.9935 1910302 Bionet1_003651 OC(CN1CCN(CC1)C(c2ccccc2)c3ccccc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C14 compound treatment 0.353 0.00225 0.12 0.363 0.00374 0.23 0.2411 0.951 1910303 Bionet1_003652 COC(=O)Cc1nnc2c3nnc(CC(=O)OC)n3c4ccccc4n12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C15 compound treatment 0.345 -0.00575 -0.29 0.353 -0.00626 -0.38 -0.475 -0.9923 1910304 Bionet1_003653 Oc1c(C(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n3CCCc4cccc1c43 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C16 compound treatment 0.376 0.0253 1.29 0.384 0.0247 1.49 1.9691 0.9974 1910305 Bionet1_003654 CCOC(=O)c1cnc(nc1Oc2cccc(c2)C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C17 compound treatment 0.37 0.0193 0.98 0.374 0.0147 0.89 1.3253 0.9987 1224256 Bionet1_003655 Oc1ccn(Cc2cccc(Cl)c2)c(=O)c1Cc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C18 compound treatment 0.383 0.0323 1.65 0.383 0.0237 1.43 2.1795 0.9976 1910306 Bionet1_003656 CCOC(=O)c1cnc(nc1Oc2ccc(OC)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C19 compound treatment 0.35 -7.5E-4 -0.04 0.364 0.00474 0.29 0.1753 0.607 1649511 Bionet1_003657 OCC(Cc1ccccc1)n2ccc(O)c(Cc3ccc(F)cc3)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C20 compound treatment 0.356 0.00525 0.27 0.359 -2.58E-4 -0.02 0.1788 0.665 1910307 Bionet1_003658 CN1c2ccsc2/C(=N/NC(=O)c3c(F)cccc3F)/CS1(=O)=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C21 compound treatment 0.343 -0.00775 -0.4 0.356 -0.00326 -0.2 -0.4193 -0.9477 1910308 Bionet1_003659 O=C(Sc1nnc(SCCOc2ccccc2)s1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C22 compound treatment 0.365 0.0143 0.73 0.381 0.0217 1.31 1.4433 0.9614 1910309 Bionet1_003660 CN1c2ccsc2/C(=N/NC(=O)c3ccc(Cl)cc3)/CS1(=O)=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C23 positive control 0.084 -0.267 -13.64 0.085 -0.274 -16.56 -21.3518 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 C24 positive control 0.09 -0.261 -13.33 0.095 -0.264 -15.95 -20.708 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D01 mock treatment 0.341 -0.00975 -0.5 0.35 -0.00926 -0.56 -0.7477 -0.9984 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D02 mock treatment 0.347 -0.00375 -0.19 0.353 -0.00626 -0.38 -0.4027 -0.9506 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D03 compound treatment 0.395 0.0442 2.26 0.417 0.0577 3.49 4.0647 0.9781 1910310 Bionet1_003661 COc1ccc(NC(=O)c2cc3CSc4ccc(C)cc4-c3s2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D04 compound treatment 0.366 0.0153 0.78 0.371 0.0117 0.71 1.0526 0.9989 1910311 Bionet1_003662 O=C(Oc1ccc(cc1)c2nccc(n2)c3cccs3)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D05 compound treatment 0.362 0.0113 0.58 0.367 0.00774 0.47 0.7372 0.9947 1910312 Bionet1_003663 Cc1ccc2SCc3cc(sc3-c2c1)C(=O)Nc4ccc(F)cc4F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D06 compound treatment 0.388 0.0372 1.9 0.383 0.0237 1.43 2.3603 0.9902 1459451 Bionet1_003664 Cc1cccc(c1)C(=O)Oc2ccc(cc2)c3nccc(n3)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D07 compound treatment 0.378 0.0273 1.39 0.378 0.0187 1.13 1.7853 0.9947 1910313 Bionet1_003665 Cc1ccc2SCc3cc(sc3-c2c1)C(=O)Nc4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D08 compound treatment 0.368 0.0173 0.88 0.368 0.00874 0.53 0.9969 0.9698 1730123 Bionet1_003666 O=C(Oc1ccc(cc1)c2nccc(n2)c3cccs3)C4CCCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D09 compound treatment 0.383 0.0323 1.65 0.386 0.0267 1.61 2.3076 0.9999 1910314 Bionet1_003667 Cc1ccc2SCc3cc(sc3-c2c1)C(=O)Nc4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D10 compound treatment 0.359 0.00825 0.42 0.361 0.00174 0.11 0.3726 0.8571 1910315 Bionet1_003668 CC(C)(C)c1ccc(cc1)C(=O)N/N=C/c2ccc(OCCCF)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D11 compound treatment 0.385 0.0343 1.75 0.389 0.0297 1.8 2.5079 0.9999 1910316 Bionet1_003669 Cc1ccc2SCc3cc(sc3-c2c1)C(=O)Nc4ccc(Cl)cc4C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D12 compound treatment 0.347 -0.00375 -0.19 0.355 -0.00426 -0.26 -0.3173 -0.9896 1910317 Bionet1_003670 FCCCOc1ccc(/C=N/NC(=O)c2ccc(Cl)cc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D13 compound treatment 0.407 0.0563 2.88 0.43 0.0707 4.27 5.0535 0.9815 1378719 Bionet1_003671 Cc1ccc2SCc3cc(sc3-c2c1)C(=O)Oc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D14 compound treatment 0.372 0.0213 1.09 0.407 0.0477 2.88 2.8063 0.9111 1910318 Bionet1_003672 Clc1ccc(COc2ccc(/C=C\3/SC(=O)NC3=O)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D15 compound treatment 0.346 -0.00475 -0.24 0.349 -0.0103 -0.62 -0.6096 -0.9165 1379260 Bionet1_003673 Cc1ccc2SCc3cc(sc3-c2c1)C(=O)Oc4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D16 compound treatment 0.428 0.0772 3.95 0.428 0.0687 4.15 5.7274 0.9997 1910319 Bionet1_003674 Brc1ccc(COc2ccc(/C=C\3/SC(=O)NC3=O)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D17 compound treatment 0.35 -7.5E-4 -0.04 0.366 0.00674 0.41 0.2607 0.6377 1910320 Bionet1_003675 Fc1ccccc1N2CCN(CC(=O)Nc3nnc(s3)C(F)(F)F)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D18 compound treatment 0.365 0.0143 0.73 0.371 0.0117 0.71 1.0164 0.9999 1645641 Bionet1_003676 O=C(NC1CCCCC1)Oc2ccc(cc2)c3nccc(n3)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D19 compound treatment 0.346 -0.00475 -0.24 0.363 0.00374 0.23 -0.012 -0.0362 1910321 Bionet1_003677 Fc1ccc(cc1)N2CCN(CC(=O)Nc3nnc(s3)C(F)(F)F)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D20 compound treatment 0.352 0.00125 0.06 0.362 0.00274 0.17 0.1622 0.9143 1910322 Bionet1_003678 CN1C(=O)N(C)C(=O)C(=Cc2ccc(OCc3ccccc3)cc2)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D21 compound treatment 0.344 -0.00675 -0.35 0.351 -0.00826 -0.5 -0.5966 -0.9839 1910323 Bionet1_003679 Clc1ccccc1c2nc(no2)c3cc(oc3n4cccc4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D22 compound treatment 0.352 0.00125 0.06 0.353 -0.00626 -0.38 -0.2219 -0.5792 1394938 Bionet1_003680 O=C(Oc1ccc(cc1)c2nccc(n2)c3cccs3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D23 positive control 0.085 -0.266 -13.59 0.087 -0.272 -16.44 -21.2303 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 D24 positive control 0.091 -0.26 -13.28 0.094 -0.265 -16.01 -20.7146 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E01 mock treatment 0.347 -0.00375 -0.19 0.351 -0.00826 -0.5 -0.4881 -0.9138 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E02 mock treatment 0.354 0.00325 0.17 0.36 7.42E-4 0.04 0.1492 0.8668 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E03 compound treatment 0.352 0.00125 0.06 0.357 -0.00226 -0.14 -0.0512 -0.34 1387635 Bionet1_003681 Oc1ccn(Cc2ccc(F)cc2)c(=O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E04 compound treatment 0.356 0.00525 0.27 0.36 7.42E-4 0.04 0.2215 0.8138 1910324 Bionet1_003682 CN1c2ccsc2/C(=N/NC(=O)Cc3cccs3)/CS1(=O)=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E05 compound treatment 0.354 0.00325 0.17 0.359 -2.58E-4 -0.02 0.1065 0.638 1254553 Bionet1_003683 CCOC(=O)C(Cc1c(F)cccc1Cl)c2ccnc3nc(N)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E06 compound treatment 0.344 -0.00675 -0.35 0.354 -0.00526 -0.32 -0.4685 -0.9991 1910325 Bionet1_003684 COC(=O)c1sccc1Oc2cc(nc(SC)n2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E07 compound treatment 0.349 -0.00175 -0.09 0.351 -0.00826 -0.5 -0.4158 -0.8209 1335360 Bionet1_003685 Oc1ccn(CCCN2CCOCC2)c(=O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E08 compound treatment 0.361 0.0103 0.52 0.367 0.00774 0.47 0.7011 0.9984 1910326 Bionet1_003686 CC(OC(=O)Nc1cccc(c1)C(F)(F)F)c2sc3ncnn3c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E09 compound treatment 0.352 0.00125 0.06 0.362 0.00274 0.17 0.1622 0.9143 1151858 Bionet1_003687 Oc1ccn(CCc2ccccn2)c(=O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E10 compound treatment 0.356 0.00525 0.27 0.36 7.42E-4 0.04 0.2215 0.8138 1910327 Bionet1_003688 CC(OC(=O)NS(=O)(=O)c1ccc(C)cc1)c2sc3ncnn3c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E11 compound treatment 0.351 2.5E-4 0.01 0.364 0.00474 0.29 0.2115 0.7379 1525023 Bionet1_003689 CCOC(=O)C(Cc1c(F)cccc1Cl)c2ccnn2c3cccc(F)n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E12 compound treatment 0.381 0.0302 1.55 0.39 0.0307 1.86 2.406 0.9959 1910328 Bionet1_003690 COc1cccc(Sc2nc(SCc3ccccc3)nc4ccsc24)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E13 compound treatment 0.36 0.00925 0.47 0.366 0.00674 0.41 0.6222 0.9972 1229087 Bionet1_003691 Oc1ccn(Cc2cccc(Cl)c2)c(=O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E14 compound treatment 0.374 0.0233 1.19 0.391 0.0317 1.92 2.1956 0.9736 1910329 Bionet1_003692 Cc1ccc(Sc2nc(SCc3ccccc3)nc4ccsc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E15 compound treatment 0.359 0.00825 0.42 0.371 0.0117 0.71 0.7995 0.9693 1297010 Bionet1_003693 Oc1ccn(Cc2ccc3OCOc3c2)c(=O)c1Cc4c(F)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E16 compound treatment 0.373 0.0222 1.14 0.386 0.0267 1.61 1.946 0.9853 1910330 Bionet1_003694 COc1ccc(Oc2nc(SCc3ccccc3)nc4ccsc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E17 compound treatment 0.343 -0.00775 -0.4 0.352 -0.00726 -0.44 -0.59 -0.9987 1424403 Bionet1_003695 CN1CC(C(C1)C(=O)c2ccc(Cl)cc2)C(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E18 compound treatment 0.358 0.00725 0.37 0.365 0.00574 0.35 0.5072 0.9994 1910331 Bionet1_003696 Fc1ccc(Oc2nc(SCc3ccccc3)nc4ccsc24)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E19 compound treatment 0.337 -0.0138 -0.7 0.355 -0.00426 -0.26 -0.6789 -0.9069 1143157 Bionet1_003697 COc1ccc(cc1)C(=O)C2CN(C)CC2C(=O)c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E20 compound treatment 0.372 0.0213 1.09 0.39 0.0307 1.86 2.0806 0.9675 1910332 Bionet1_003698 Cc1ccc(Oc2nc(SCc3ccccc3)nc4ccsc24)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E21 compound treatment 0.36 0.00925 0.47 0.364 0.00474 0.29 0.5369 0.9711 1291386 Bionet1_003699 COc1ccc(NC(=O)c2c(O)c3cccc4CCCn(c2=O)c43)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E22 compound treatment 0.367 0.0163 0.83 0.376 0.0167 1.01 1.3022 0.9953 1910333 Bionet1_003700 C=CCSc1nc(Oc2ccc3ccccc3c2)c4sccc4n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E23 positive control 0.085 -0.266 -13.59 0.088 -0.271 -16.38 -21.1876 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 E24 positive control 0.092 -0.259 -13.23 0.097 -0.262 -15.83 -20.5504 -0.996 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F01 mock treatment 0.349 -0.00175 -0.09 0.355 -0.00426 -0.26 -0.245 -0.9003 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F02 mock treatment 0.354 0.00325 0.17 0.367 0.00774 0.47 0.448 0.9031 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F03 compound treatment 0.375 0.0243 1.24 0.389 0.0297 1.8 2.1464 0.9837 1910334 Bionet1_003701 Nc1c(C#N)c(SCc2ccccc2)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F04 compound treatment 0.36 0.00925 0.47 0.368 0.00874 0.53 0.7076 0.9985 1687952 Bionet1_003702 Clc1ccc(cc1)C(=O)Oc2ccc(cc2)c3nccc(n3)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F05 compound treatment 0.404 0.0532 2.72 0.421 0.0617 3.73 4.5609 0.9881 1910335 Bionet1_003703 COc1ccc(CSc2sc(C(=O)c3ccccc3)c(N)c2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F06 compound treatment 0.407 0.0563 2.88 0.43 0.0707 4.27 5.0535 0.9815 1910336 Bionet1_003704 Clc1ccc(N/N=C/c2ccc(OCc3ccccc3)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F07 compound treatment 0.379 0.0283 1.44 0.391 0.0317 1.92 2.3764 0.9903 1910337 Bionet1_003705 Cc1ccccc1CSc2sc(C(=O)c3ccccc3)c(N)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F08 compound treatment 0.387 0.0362 1.85 0.389 0.0297 1.8 2.5802 0.9999 1910338 Bionet1_003706 CC(C)(C)c1ccc(N/N=C/c2ccc(OCc3ccccc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F09 compound treatment 0.43 0.0793 4.05 0.442 0.0827 4.99 6.3974 0.9946 1910339 Bionet1_003707 Nc1c(C#N)c(SCC(=O)c2ccccc2)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F10 compound treatment 0.381 0.0302 1.55 0.393 0.0337 2.04 2.5341 0.9908 1910340 Bionet1_003708 Clc1ccc(CO/N=C/c2ccc(OCc3ccccc3)cc2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F11 compound treatment 0.383 0.0323 1.65 0.389 0.0297 1.8 2.4356 0.9991 1910341 Bionet1_003709 Nc1c(sc2sc(C(=O)c3ccccc3)c(N)c12)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F12 compound treatment 0.363 0.0123 0.63 0.375 0.0157 0.95 1.1149 0.9795 1910342 Bionet1_003710 COC(=O)c1cc2cc(NS(=O)(=O)c3ccc(C)cc3)ccc2s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F13 compound treatment 0.418 0.0673 3.44 0.425 0.0657 3.97 5.2378 0.9974 1910343 Bionet1_003711 Nc1c(C#N)c(SCc2cccc(F)c2)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F14 compound treatment 0.364 0.0133 0.68 0.369 0.00974 0.59 0.8949 0.9975 1910344 Bionet1_003712 CCOC(=O)c1cnn(c1n2cccc2C(=O)C(=O)NCC=C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F15 compound treatment 0.395 0.0442 2.26 0.421 0.0617 3.73 4.2355 0.9714 1910345 Bionet1_003713 Nc1c(C#N)c(SCc2ccc(F)cc2)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F16 compound treatment 0.367 0.0163 0.83 0.367 0.00774 0.47 0.918 0.963 1910346 Bionet1_003714 CCOC(=O)c1cnn(c1n2cccc2C(=O)C(=O)N(C)C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F17 compound treatment 0.399 0.0483 2.47 0.424 0.0647 3.91 4.5082 0.9754 1910347 Bionet1_003715 Cc1ccc(CSc2sc(C(=O)c3ccccc3)c(N)c2C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F18 compound treatment 0.368 0.0173 0.88 0.371 0.0117 0.71 1.1249 0.9941 1910348 Bionet1_003716 CC(C)Sc1nnc(c2cnn(c2n3cccc3)c4ccccc4)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F19 compound treatment 0.45 0.0993 5.07 0.446 0.0867 5.24 7.2912 0.9999 1910349 Bionet1_003717 Nc1c(C#N)c(SCc2cccc(Cl)c2)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F20 compound treatment 0.365 0.0143 0.73 0.376 0.0167 1.01 1.2299 0.9871 1910350 Bionet1_003718 CCSc1nnc(c2cnn(c2n3cccc3)c4ccccc4)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F21 compound treatment 0.391 0.0403 2.06 0.398 0.0387 2.34 3.1091 0.998 1910351 Bionet1_003719 Nc1c(C#N)c(SCc2ccc(Cl)cc2)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F22 compound treatment 0.354 0.00325 0.17 0.364 0.00474 0.29 0.3199 0.9665 1910352 Bionet1_003720 FC(F)(F)c1cc(=O)n(nc1C(=O)Nc2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F23 positive control 0.097 -0.254 -12.97 0.09 -0.269 -16.25 -20.6684 -0.9938 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 F24 positive control 0.091 -0.26 -13.28 0.094 -0.265 -16.01 -20.7146 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G01 mock treatment 0.347 -0.00375 -0.19 0.351 -0.00826 -0.5 -0.4881 -0.9138 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G02 mock treatment 0.347 -0.00375 -0.19 0.356 -0.00326 -0.2 -0.2747 -0.9999 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G03 compound treatment 0.348 -0.00275 -0.14 0.354 -0.00526 -0.32 -0.3239 -0.9329 1910353 Bionet1_003721 CC(=O)C(Cc1cnc(Cl)s1)(Cc2cnc(Cl)s2)C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G04 compound treatment 0.347 -0.00375 -0.19 0.358 -0.00126 -0.08 -0.1893 -0.9178 1240057 Bionet1_003722 COC(=O)c1ccccc1Oc2nc(SCC=C)nc3ccsc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G05 compound treatment 0.348 -0.00275 -0.14 0.365 0.00574 0.35 0.1457 0.3894 1183374 Bionet1_003723 COc1ccc(CCn2ccc(O)c(Cc3ccccc3)c2=O)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G06 compound treatment 0.341 -0.00975 -0.5 0.357 -0.00226 -0.14 -0.4489 -0.8686 1910354 Bionet1_003724 Cc1c(sc2ncnn12)/C(=N\O)/CSCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G07 compound treatment 0.359 0.00825 0.42 0.367 0.00774 0.47 0.6288 0.9987 1227988 Bionet1_003725 Oc1ccn(Cc2ccc(Cl)cc2Cl)c(=O)c1Cc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G08 compound treatment 0.344 -0.00675 -0.35 0.384 0.0247 1.49 0.8121 0.5298 1491407 Bionet1_003726 Clc1ccc(cc1)C(=O)CSc2nc3n(ncc3c(=O)[nH]2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G09 compound treatment 0.355 0.00425 0.22 0.377 0.0177 1.07 0.911 0.8336 1910355 Bionet1_003727 Clc1cccc(C(=O)NNC(=O)c2sccc2n3cccc3)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G10 compound treatment 0.347 -0.00375 -0.19 0.369 0.00974 0.59 0.2803 0.4531 1910356 Bionet1_003728 Clc1ccc(cc1)c2csc3nc4n(ncc4c(=O)n23)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G11 compound treatment 0.353 0.00225 0.12 0.399 0.0397 2.4 1.7778 0.7402 1910357 Bionet1_003729 C/C(=N\OCc1ccc(Cl)cc1)/c2sc3nc4ccccc4n3c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G12 compound treatment 0.364 0.0133 0.68 0.404 0.0447 2.7 2.389 0.8579 1286687 Bionet1_003730 COc1ccc(cc1)C(=O)CSc2nc3n(ncc3c(=O)[nH]2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G13 compound treatment 0.361 0.0103 0.52 0.395 0.0357 2.16 1.8963 0.854 1376211 Bionet1_003731 COC(=O)CSc1nnc(s1)c2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G14 compound treatment 0.378 0.0273 1.39 0.403 0.0437 2.64 2.8525 0.9554 1492995 Bionet1_003732 O=C(CSc1nc2n(ncc2c(=O)[nH]1)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G15 compound treatment 0.36 0.00925 0.47 0.408 0.0487 2.94 2.4151 0.8104 1445945 Bionet1_003733 CC(C)(C)c1cc(cc(c1O)C(C)(C)C)c2nnc(SCC=C)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G16 compound treatment 0.382 0.0313 1.6 0.404 0.0447 2.7 3.0398 0.9686 1910358 Bionet1_003734 Brc1ccc(cc1)C2=Nn3c(nnc3SC2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G17 compound treatment 0.353 0.00225 0.12 0.369 0.00974 0.59 0.4972 0.8297 1910359 Bionet1_003735 FC(F)(F)c1cccc(c1)n2ccc(=O)c(n2)C(=O)Nc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G18 compound treatment 0.366 0.0153 0.78 0.378 0.0187 1.13 1.3514 0.9835 1161908 Bionet1_003736 Brc1cc(Br)c2oc(cc2c1)C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G19 compound treatment 0.351 2.5E-4 0.01 0.366 0.00674 0.41 0.2968 0.729 1910360 Bionet1_003737 COc1cccc(c1)C(=O)O/N=C(\C)/c2sc3nc4ccccc4n3c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G20 compound treatment 0.373 0.0222 1.14 0.4 0.0407 2.46 2.5436 0.9386 1910361 Bionet1_003738 O/N=C(\c1cc2cc(Br)cc(Br)c2o1)/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G21 compound treatment 0.354 0.00325 0.17 0.364 0.00474 0.29 0.3199 0.9665 1712484 Bionet1_003739 Clc1ccc(CN2CCN(CC2)c3nc4ccccc4s3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G22 compound treatment 0.35 -7.5E-4 -0.04 0.356 -0.00326 -0.2 -0.1662 -0.8294 1910362 Bionet1_003740 COc1ccc(cc1)c2nnc(SCc3ccc(Cl)cc3Cl)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G23 positive control 0.091 -0.26 -13.28 0.09 -0.269 -16.25 -20.8853 -0.995 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 G24 positive control 0.093 -0.258 -13.18 0.097 -0.262 -15.83 -20.5142 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H01 mock treatment 0.353 0.00225 0.12 0.364 0.00474 0.29 0.2838 0.9198 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H02 mock treatment 0.351 2.5E-4 0.01 0.361 0.00174 0.11 0.0834 0.7873 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H03 compound treatment 0.354 0.00325 0.17 0.369 0.00974 0.59 0.5334 0.8727 1910363 Bionet1_003741 Nc1c(C#N)c(SCc2ccccc2Cl)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H04 compound treatment 0.367 0.0163 0.83 0.383 0.0237 1.43 1.601 0.9664 1910364 Bionet1_003742 FC(F)(F)c1cc(=O)n(nc1C(=O)Nc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H05 compound treatment 0.417 0.0663 3.39 0.47 0.111 6.69 7.1226 0.9504 1910365 Bionet1_003743 Nc1c(C#N)c(SCC(=O)c2ccc(F)cc2)sc1C(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H06 compound treatment 0.355 0.00425 0.22 0.352 -0.00726 -0.44 -0.1562 -0.3193 1910366 Bionet1_003744 FC(F)(F)c1cccc(NC(=O)C2CCC(=O)N2Cc3cccs3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H07 compound treatment 0.358 0.00725 0.37 0.364 0.00474 0.29 0.4645 0.9918 1910367 Bionet1_003745 Cc1cccn2c(/C=N/OC(=O)c3cccs3)c(nc12)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H08 compound treatment 0.355 0.00425 0.22 0.366 0.00674 0.41 0.4415 0.9568 1910368 Bionet1_003746 FC(F)(F)c1cccc(NC(=O)C2CCC(=O)N2Cc3ccccc3Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H09 compound treatment 0.363 0.0123 0.63 0.381 0.0217 1.31 1.371 0.9427 1910369 Bionet1_003747 Cc1ccc(cc1)C(=O)O/N=C/c2c(nc3ccc(Cl)cn23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H10 compound treatment 0.357 0.00625 0.32 0.366 0.00674 0.41 0.5138 0.9928 1448522 Bionet1_003748 Clc1ccc(NC(=O)C2CCC(=O)N2Cc3ccccc3Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H11 compound treatment 0.373 0.0222 1.14 0.385 0.0257 1.55 1.9033 0.9883 1910370 Bionet1_003749 Cc1cccn2c(/C=N/OC(=O)C3CC3)c(nc12)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H12 compound treatment 0.35 -7.5E-4 -0.04 0.357 -0.00226 -0.14 -0.1235 -0.8722 1590698 Bionet1_003750 Clc1ccc(NC(=O)C2CCC(=O)N2Cc3ccccc3Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H13 compound treatment 0.352 0.00125 0.06 0.364 0.00474 0.29 0.2476 0.8442 1910371 Bionet1_003751 O=C(NN=C1CCN(CC1)S(=O)(=O)c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H14 compound treatment 0.362 0.0113 0.58 0.377 0.0177 1.07 1.1641 0.9575 1910372 Bionet1_003752 FC(F)(F)c1ccc(NC(=O)C2CCC(=O)N2Cc3cccs3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H15 compound treatment 0.359 0.00825 0.42 0.366 0.00674 0.41 0.5861 0.9998 1910373 Bionet1_003753 O=C(ON=C1CCN(CC1)S(=O)(=O)c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H16 compound treatment 0.372 0.0213 1.09 0.375 0.0157 0.95 1.4403 0.9978 1150108 Bionet1_003754 Clc1ccc(cc1)S(=O)(=O)N2CCC(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H17 compound treatment 0.399 0.0483 2.47 0.389 0.0297 1.8 3.0141 0.9878 1910374 Bionet1_003755 CCOC(=O)c1cnc2c(C)cccc2c1Nc3ccc(OC(F)(F)F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H18 compound treatment 0.381 0.0302 1.55 0.388 0.0287 1.74 2.3206 0.9984 1555155 Bionet1_003756 Fc1ccc(cc1)S(=O)(=O)N2CCC(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H19 compound treatment 0.355 0.00425 0.22 0.371 0.0117 0.71 0.6549 0.8833 1910375 Bionet1_003757 Clc1ccc(cc1)C(=O)NN=C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H20 compound treatment 0.373 0.0222 1.14 0.382 0.0227 1.37 1.7753 0.9956 1452723 Bionet1_003758 Cc1ccc(cc1)S(=O)(=O)N2CCC(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H21 compound treatment 0.361 0.0103 0.52 0.371 0.0117 0.71 0.8718 0.989 1910376 Bionet1_003759 Fc1ccc(cc1)C(=O)NN=C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H22 compound treatment 0.363 0.0123 0.63 0.369 0.00974 0.59 0.8588 0.9995 1910377 Bionet1_003760 FC(F)(F)S(=O)(=O)N1CCC(CC1)c2nc3ccccc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H23 positive control 0.09 -0.261 -13.33 0.092 -0.267 -16.13 -20.8361 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 H24 positive control 0.098 -0.253 -12.92 0.098 -0.261 -15.77 -20.2907 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I01 mock treatment 0.348 -0.00275 -0.14 0.353 -0.00626 -0.38 -0.3666 -0.9093 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I02 mock treatment 0.351 2.5E-4 0.01 0.362 0.00274 0.17 0.1261 0.7595 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I03 compound treatment 0.356 0.00525 0.27 0.366 0.00674 0.41 0.4776 0.9796 1910378 Bionet1_003761 [O-][N+](=O)c1ccc(CN2CCN(CC2)c3nc4ccccc4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I04 compound treatment 0.362 0.0113 0.58 0.366 0.00674 0.41 0.6945 0.9856 1455660 Bionet1_003762 CCOC(=O)COc1ccc(cc1)c2nccc(n2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I05 compound treatment 0.361 0.0103 0.52 0.373 0.0137 0.83 0.9572 0.9755 1910379 Bionet1_003763 FC(F)(F)c1cccc(CN2CCN(CC2)c3nc4ccccc4s3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I06 compound treatment 0.379 0.0283 1.44 0.389 0.0297 1.8 2.291 0.9942 1910380 Bionet1_003764 COC(=O)COc1ccc(cc1)c2nccc(n2)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I07 compound treatment 0.348 -0.00275 -0.14 0.356 -0.00326 -0.2 -0.2385 -0.9865 1332242 Bionet1_003765 Fc1cccc(Cl)c1CN2CCN(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I08 compound treatment 0.36 0.00925 0.47 0.37 0.0107 0.65 0.793 0.988 1910381 Bionet1_003766 CCCCCCCc1ccc(CNc2ccc(cc2)C(=O)OCC)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I09 compound treatment 0.348 -0.00275 -0.14 0.357 -0.00226 -0.14 -0.1958 -0.9999 1910382 Bionet1_003767 FC(F)(F)c1cccc(c1)C(=O)N2CCN(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I10 compound treatment 0.354 0.00325 0.17 0.371 0.0117 0.71 0.6187 0.8498 1910383 Bionet1_003768 COc1ccc(cc1)C(=O)c2nnn(c2C)c3cc(Cl)cc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I11 compound treatment 0.356 0.00525 0.27 0.373 0.0137 0.83 0.7764 0.8905 1673809 Bionet1_003769 Clc1ccc(cc1)C(=O)N2CCN(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I12 compound treatment 0.348 -0.00275 -0.14 0.357 -0.00226 -0.14 -0.1958 -0.9999 1910384 Bionet1_003770 COC(=O)c1ccc(OCCCCCCOc2ccc(cc2)C(=O)OC)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I13 compound treatment 0.366 0.0153 0.78 0.366 0.00674 0.41 0.8392 0.954 1379240 Bionet1_003771 COc1cccc(c1)C(=O)N2CCN(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I14 compound treatment 0.385 0.0343 1.75 0.381 0.0217 1.31 2.1664 0.9899 1567386 Bionet1_003772 CC(C)(C)c1ccc(Oc2ccc(cc2)c3nc(N)c(C#N)c(C#N)c3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I15 compound treatment 0.365 0.0143 0.73 0.366 0.00674 0.41 0.803 0.9622 1149384 Bionet1_003773 COc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I16 compound treatment 0.421 0.0703 3.59 0.395 0.0357 2.16 4.0657 0.9703 1910385 Bionet1_003774 [O-][N+](=O)c1ccc(NCCc2c[nH]c3ccccc23)c(Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I17 compound treatment 0.369 0.0182 0.93 0.388 0.0287 1.74 1.8868 0.9577 1147923 Bionet1_003775 O=S(=O)(N1CCN(CC1)c2nc3ccccc3s2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I18 compound treatment 0.355 0.00425 0.22 0.372 0.0127 0.77 0.6976 0.8727 1910386 Bionet1_003776 CCOC(=O)C(CSC(=O)c1ccc(cc1)[N+](=O)[O-])NC(=O)OC(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I19 compound treatment 0.361 0.0103 0.52 0.361 0.00174 0.11 0.445 0.8324 1173610 Bionet1_003777 Cc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I20 compound treatment 0.376 0.0253 1.29 0.384 0.0247 1.49 1.9691 0.9974 1910387 Bionet1_003778 Brc1ccc(cc1)C(=O)CSc2nnc(o2)c3ccco3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I21 compound treatment 0.357 0.00625 0.32 0.364 0.00474 0.29 0.4284 0.9985 1555729 Bionet1_003779 Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I22 compound treatment 0.421 0.0703 3.59 0.43 0.0707 4.27 5.5597 0.9963 1910388 Bionet1_003780 COc1cc(Br)c(O)c(/C=N/NC(=O)c2cccnc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I23 positive control 0.088 -0.263 -13.44 0.089 -0.27 -16.32 -21.0365 -0.9953 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 I24 positive control 0.096 -0.255 -13.03 0.099 -0.26 -15.71 -20.3204 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J01 mock treatment 0.353 0.00225 0.12 0.358 -0.00126 -0.08 0.0276 0.2006 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J02 mock treatment 0.358 0.00725 0.37 0.369 0.00974 0.59 0.678 0.9752 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J03 compound treatment 0.351 2.5E-4 0.01 0.359 -2.58E-4 -0.02 -0.002 -0.0981 1910389 Bionet1_003781 Cc1ccc(cc1)C(=O)NN=C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J04 compound treatment 0.357 0.00625 0.32 0.369 0.00974 0.59 0.6418 0.9589 1696263 Bionet1_003782 COc1ccc(cc1)S(=O)(=O)N2CCC(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J05 compound treatment 0.355 0.00425 0.22 0.362 0.00274 0.17 0.2707 0.991 1910390 Bionet1_003783 O=C(NN=C1CCN(CC1)S(=O)(=O)c2ccccc2)c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J06 compound treatment 0.383 0.0323 1.65 0.368 0.00874 0.53 1.5392 0.889 1491125 Bionet1_003784 O=S(=O)(N1CCC(CC1)c2nc3ccccc3s2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J07 compound treatment 0.364 0.0133 0.68 0.398 0.0387 2.34 2.1328 0.8759 1910391 Bionet1_003785 CCOC(=O)c1cnc2ccc(cc2c1NCc3ccc(C)cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J08 compound treatment 0.363 0.0123 0.63 0.38 0.0207 1.25 1.3283 0.9487 1422608 Bionet1_003786 O=S(=O)(Cc1ccccc1)N2CCC(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J09 compound treatment 0.385 0.0343 1.75 0.398 0.0387 2.34 2.8921 0.9898 1910392 Bionet1_003787 CCOC(=O)c1cnc2ccc(cc2c1Nc3ccccc3F)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J10 compound treatment 0.349 -0.00175 -0.09 0.359 -2.58E-4 -0.02 -0.0743 -0.8179 1412011 Bionet1_003788 Clc1ccc(cc1)S(=O)(=O)N2CCCC2c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J11 compound treatment 0.358 0.00725 0.37 0.374 0.0147 0.89 0.8914 0.9246 1910393 Bionet1_003789 Clc1ccc(cc1Cl)C(=O)Nc2ccc3sc4ccccc4c(=O)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J12 compound treatment 0.348 -0.00275 -0.14 0.358 -0.00126 -0.08 -0.1531 -0.9582 1202686 Bionet1_003790 Cc1ccc(cc1)S(=O)(=O)N2CCCC2c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J13 compound treatment 0.37 0.0193 0.98 0.406 0.0467 2.82 2.6913 0.9005 1910394 Bionet1_003791 Clc1cccc(c1)C(=O)Nc2ccc3sc4ccccc4c(=O)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J14 compound treatment 0.344 -0.00675 -0.35 0.358 -0.00126 -0.08 -0.2978 -0.8425 1334878 Bionet1_003792 COc1ccc(cc1)S(=O)(=O)N2CCCC2c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J15 compound treatment 0.377 0.0262 1.34 0.385 0.0257 1.55 2.0479 0.9973 1910395 Bionet1_003793 COc1ccc(cc1)/C(=C/c2c(nc3c(C)cccn23)c4ccc(Cl)cc4)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J16 compound treatment 0.348 -0.00275 -0.14 0.357 -0.00226 -0.14 -0.1958 -0.9999 1719153 Bionet1_003794 O=S(=O)(Cc1ccccc1)N2CCCC2c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J17 compound treatment 0.408 0.0573 2.93 0.416 0.0567 3.43 4.4921 0.9969 1910396 Bionet1_003795 COc1cccc(c1)/C(=C/c2c(nc3c(C)cccn23)c4ccc(Cl)cc4)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J18 compound treatment 0.346 -0.00475 -0.24 0.363 0.00374 0.23 -0.012 -0.0362 1910397 Bionet1_003796 COc1cc(NC(=O)c2ccc(cc2)C(=O)C(F)(F)F)c(Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J19 compound treatment 0.397 0.0462 2.36 0.424 0.0647 3.91 4.4358 0.971 1910398 Bionet1_003797 COc1cccc(c1)/C(=C/c2c(nc3cc(C)ccn23)c4ccc(Cl)cc4)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J20 compound treatment 0.364 0.0133 0.68 0.367 0.00774 0.47 0.8095 0.9836 1910399 Bionet1_003798 CCOC(=O)c1nn(c2cccc(c2)C(F)(F)F)c(=O)cc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J21 compound treatment 0.395 0.0442 2.26 0.403 0.0437 2.64 3.4671 0.997 1910400 Bionet1_003799 Cc1nc(sc1C(=O)/C=C/c2ccccc2[N+](=O)[O-])c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J22 compound treatment 0.361 0.0103 0.52 0.373 0.0137 0.83 0.9572 0.9755 1910401 Bionet1_003800 CCOC(=O)c1nn(c2ccc(cc2)C(F)(F)F)c(=O)cc1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J23 positive control 0.088 -0.263 -13.44 0.089 -0.27 -16.32 -21.0365 -0.9953 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 J24 positive control 0.094 -0.257 -13.13 0.097 -0.262 -15.83 -20.478 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K01 mock treatment 0.352 0.00125 0.06 0.361 0.00174 0.11 0.1196 0.9715 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K02 mock treatment 0.347 -0.00375 -0.19 0.354 -0.00526 -0.32 -0.36 -0.9709 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K03 compound treatment 0.347 -0.00375 -0.19 0.365 0.00574 0.35 0.1095 0.2765 1910402 Bionet1_003801 Cc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ncccc3C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K04 compound treatment 0.366 0.0153 0.78 0.378 0.0187 1.13 1.3514 0.9835 1910403 Bionet1_003802 COC(=O)c1ccc(/N=C/c2cc(OC)cc(Br)c2O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K05 compound treatment 0.358 0.00725 0.37 0.369 0.00974 0.59 0.678 0.9752 1269742 Bionet1_003803 Clc1cccc(c1)C(=O)N2CCC(CC2)c3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K06 compound treatment 0.361 0.0103 0.52 0.374 0.0147 0.89 0.9999 0.9681 1910404 Bionet1_003804 COc1cc(Br)c(O)c(/C=N/NC(=O)c2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K07 compound treatment 0.405 0.0543 2.77 0.427 0.0677 4.09 4.8532 0.9821 1910405 Bionet1_003805 CC(C)(C)c1cc(O)cc(c1/C=N/Nc2cccc3cccnc23)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K08 compound treatment 0.352 0.00125 0.06 0.362 0.00274 0.17 0.1622 0.9143 1910406 Bionet1_003806 Fc1ccccc1/C=C\2/C(OC(=O)Nc3ccccc3)C4CCN2CC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K09 compound treatment 0.36 0.00925 0.47 0.369 0.00974 0.59 0.7503 0.9942 1910407 Bionet1_003807 CCOC(=O)C(=CNc1nc(cs1)c2ccc(C)cc2)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K10 compound treatment 0.386 0.0352 1.8 0.395 0.0357 2.16 2.8002 0.996 1910408 Bionet1_003808 COc1cc(Br)c(O)c(/C=N/Cc2ccc(Cl)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K11 compound treatment 0.367 0.0163 0.83 0.372 0.0127 0.77 1.1314 0.9993 1910409 Bionet1_003809 Fc1ccc(SCc2ccc(CSc3ccc(F)cc3)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K12 compound treatment 0.358 0.00725 0.37 0.378 0.0187 1.13 1.0622 0.8921 1910410 Bionet1_003810 COc1cccc2cc(oc12)/C(=N/NC(=O)c3ccc(cc3)C(F)(F)F)/C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K13 compound treatment 0.365 0.0143 0.73 0.372 0.0127 0.77 1.0591 0.9996 1642102 Bionet1_003811 CC(C)(C)c1nc(NC(=O)Nc2ccccc2)sc1Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K14 compound treatment 0.359 0.00825 0.42 0.367 0.00774 0.47 0.6288 0.9987 1910411 Bionet1_003812 COc1cccc2cc(oc12)/C(=N/Nc3ncc(cc3Cl)C(F)(F)F)/C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K15 compound treatment 0.372 0.0213 1.09 0.394 0.0347 2.1 2.2513 0.9531 1370781 Bionet1_003813 Clc1ccc(NC(=O)Nc2nc(cs2)c3cccc4ccccc34)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K16 compound treatment 0.351 2.5E-4 0.01 0.363 0.00374 0.23 0.1688 0.7459 1492345 Bionet1_003814 CC(C)(C)C(=O)Cn1ncc(N2CCOCC2)c(Br)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K17 compound treatment 0.398 0.0473 2.42 0.397 0.0377 2.28 3.3195 0.9996 1571877 Bionet1_003815 CSc1nc(Sc2ccccc2)cc(n1)N3CCCc4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K18 compound treatment 0.358 0.00725 0.37 0.362 0.00274 0.17 0.3792 0.934 1414611 Bionet1_003816 Clc1ccc(cc1)C(=O)Cn2ncc(N3CCOCC3)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K19 compound treatment 0.376 0.0253 1.29 0.369 0.00974 0.59 1.3288 0.9366 1910412 Bionet1_003817 CCOC(=O)C(=CNc1nc(cs1)c2ccc3ccccc3c2)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K20 compound treatment 0.352 0.00125 0.06 0.364 0.00474 0.29 0.2476 0.8442 1391382 Bionet1_003818 Clc1ccc(cc1)C(=O)Cn2ncc(N3CCCC3)c(Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K21 compound treatment 0.352 0.00125 0.06 0.357 -0.00226 -0.14 -0.0512 -0.34 1441061 Bionet1_003819 Oc1ccn(CCc2c[nH]c3ccccc23)c(=O)c1Cc4c(F)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K22 compound treatment 0.361 0.0103 0.52 0.361 0.00174 0.11 0.445 0.8324 1910413 Bionet1_003820 CO/N=C(\Cn1ncc(N2CCOCC2)c(Cl)c1=O)/c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K23 positive control 0.088 -0.263 -13.44 0.088 -0.271 -16.38 -21.0792 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 K24 positive control 0.096 -0.255 -13.03 0.098 -0.261 -15.77 -20.363 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L01 mock treatment 0.355 0.00425 0.22 0.358 -0.00126 -0.08 0.1 0.4342 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L02 mock treatment 0.357 0.00625 0.32 0.368 0.00874 0.53 0.5991 0.9711 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L03 compound treatment 0.364 0.0133 0.68 0.379 0.0197 1.19 1.3218 0.9642 1910414 Bionet1_003821 Clc1ccc(Oc2ccccc2/C=C\3/SC(=O)NC3=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L04 compound treatment 0.354 0.00325 0.17 0.362 0.00274 0.17 0.2346 1.0 1910415 Bionet1_003822 [O-][N+](=O)c1ccc2sc(cc2c1)C(=O)Nc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L05 compound treatment 0.339 -0.0118 -0.6 0.359 -2.58E-4 -0.02 -0.4358 -0.7252 1910416 Bionet1_003823 Clc1ccc(Oc2ccccc2C=C3C(=O)NC(=O)NC3=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L06 compound treatment 0.359 0.00825 0.42 0.367 0.00774 0.47 0.6288 0.9987 1910417 Bionet1_003824 COC(=O)c1ccc(NC(=O)c2cc3cc(ccc3s2)[N+](=O)[O-])cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L07 compound treatment 0.395 0.0442 2.26 0.396 0.0367 2.22 3.1683 1.0 1910418 Bionet1_003825 Fc1cc(Br)ccc1Oc2ccccc2/C=C/3\SC(=O)NC3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L08 compound treatment 0.355 0.00425 0.22 0.362 0.00274 0.17 0.2707 0.991 1452589 Bionet1_003826 Clc1ncc(CC(Cc2cnc(Cl)s2)c3ccnc4ncnn34)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L09 compound treatment 0.414 0.0633 3.23 0.429 0.0697 4.21 5.2639 0.9915 1910419 Bionet1_003827 Fc1cc(Oc2ccccc2/C=C/3\SC(=O)NC3=O)ccc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L10 compound treatment 0.36 0.00925 0.47 0.359 -2.58E-4 -0.02 0.3234 0.6834 1910420 Bionet1_003828 [O-][N+](=O)c1ccc(Oc2ccc(Cl)c(Cl)c2)c(Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L11 compound treatment 0.346 -0.00475 -0.24 0.357 -0.00226 -0.14 -0.2681 -0.9627 1910421 Bionet1_003829 CN1C(=O)N(C)C(=O)C(=Cc2ccccc2Oc3ccc(Cl)cc3)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L12 compound treatment 0.349 -0.00175 -0.09 0.358 -0.00126 -0.08 -0.117 -0.9967 1910422 Bionet1_003830 [O-][N+](=O)c1ccc(Oc2cc(Cl)cc(Cl)c2)c(Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L13 compound treatment 0.365 0.0143 0.73 0.376 0.0167 1.01 1.2299 0.9871 1910423 Bionet1_003831 FC(F)(F)c1ccc(cc1)c2nnc(SCC(=O)c3ccc(Cl)cc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L14 compound treatment 0.357 0.00625 0.32 0.361 0.00174 0.11 0.3003 0.8927 1910424 Bionet1_003832 COCCCNC(=O)/C=C/c1ccc(OCc2c(F)cccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L15 compound treatment 0.357 0.00625 0.32 0.366 0.00674 0.41 0.5138 0.9928 1910425 Bionet1_003833 COc1ccc(cc1)S(=O)(=O)Oc2ccc(c(F)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L16 compound treatment 0.364 0.0133 0.68 0.367 0.00774 0.47 0.8095 0.9836 1910426 Bionet1_003834 Fc1cccc(Cl)c1COc2ccc(/C=C/C(=O)N3CCOCC3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L17 compound treatment 0.369 0.0182 0.93 0.368 0.00874 0.53 1.033 0.9636 1910427 Bionet1_003835 Fc1cc(OC(=O)c2cccc(c2)C(F)(F)F)ccc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L18 compound treatment 0.383 0.0323 1.65 0.382 0.0227 1.37 2.1368 0.9959 1910428 Bionet1_003836 Fc1cccc(Cl)c1COc2ccc(/C=C/C(=O)NC3CCCC3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L19 compound treatment 0.398 0.0473 2.42 0.405 0.0457 2.76 3.661 0.9978 1364921 Bionet1_003837 COc1ccc(cc1)c2ccnc(n2)c3ccc(OC(=O)c4ccco4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L20 compound treatment 0.375 0.0243 1.24 0.381 0.0217 1.31 1.8049 0.9996 1910429 Bionet1_003838 Cc1ccccc1NC(=O)/C=C/c2ccc(OCc3c(F)cccc3Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L21 compound treatment 0.359 0.00825 0.42 0.361 0.00174 0.11 0.3726 0.8571 1910430 Bionet1_003839 COc1ccc(cc1)c2ccnc(n2)c3ccc(OC(=O)c4cccs4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L22 compound treatment 0.363 0.0123 0.63 0.373 0.0137 0.83 1.0295 0.9904 1910431 Bionet1_003840 O=C/1/C(=C/c2ccccc2)/CN(Cc3ccccc3)C\C1=C/c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L23 positive control 0.088 -0.263 -13.44 0.088 -0.271 -16.38 -21.0792 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 L24 positive control 0.096 -0.255 -13.03 0.1 -0.259 -15.65 -20.2777 -0.9958 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M01 mock treatment 0.359 0.00825 0.42 0.36 7.42E-4 0.04 0.33 0.7778 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M02 mock treatment 0.361 0.0103 0.52 0.374 0.0147 0.89 0.9999 0.9681 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M03 compound treatment 0.353 0.00225 0.12 0.365 0.00574 0.35 0.3265 0.8939 1128240 Bionet1_003841 Oc1ccn(CCCn2ccnc2)c(=O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M04 compound treatment 0.352 0.00125 0.06 0.366 0.00674 0.41 0.333 0.8082 1324499 Bionet1_003842 Clc1cccc(Cl)c1SCC2CSc3nc4ccccc4c(=O)n23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M05 compound treatment 0.374 0.0233 1.19 0.387 0.0277 1.67 2.0248 0.9859 1712969 Bionet1_003843 CC(C)(Cn1ccc(O)c(Cc2ccccc2)c1=O)SCc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M06 compound treatment 0.323 -0.0278 -1.42 0.343 -0.0163 -0.98 -1.6973 -0.9838 1123883 Bionet1_003844 COc1cccc(SCC2CSc3nc4ccccc4c(=O)n23)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M07 compound treatment 0.358 0.00725 0.37 0.369 0.00974 0.59 0.678 0.9752 1910432 Bionet1_003845 CCOC(=O)C(Cc1ccccc1)c2ccnc3nc(nn23)n4c(C)ccc4C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M08 compound treatment 0.382 0.0313 1.6 0.394 0.0347 2.1 2.6129 0.991 1910433 Bionet1_003846 CN1c2ccccc2C(=C(C(=S)Nc3ccc(Cl)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M09 compound treatment 0.362 0.0113 0.58 0.369 0.00974 0.59 0.8226 0.9999 1494949 Bionet1_003847 Oc1ccn(C2CCCCCC2)c(=O)c1Cc3c(F)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M10 compound treatment 0.386 0.0352 1.8 0.408 0.0487 2.94 3.3551 0.9723 1453081 Bionet1_003848 COc1ccccc1NC(=S)C2=C(O)c3ccccc3N(C)S2(=O)=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M11 compound treatment 0.369 0.0182 0.93 0.375 0.0157 0.95 1.3318 1.0 1910434 Bionet1_003849 COC(=O)/C(=C\Nc1ccc(Cl)cc1)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M12 compound treatment 0.402 0.0512 2.62 0.406 0.0467 2.82 3.8483 0.9993 1298145 Bionet1_003850 CN1c2ccccc2C(=C(C(=S)Nc3ccc(C)cc3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M13 compound treatment 0.364 0.0133 0.68 0.374 0.0147 0.89 1.1084 0.9909 1910435 Bionet1_003851 FC(F)(F)c1cnc(c(Cl)c1)c2c[nH]c3ccc(Cl)cc3c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M14 compound treatment 0.37 0.0193 0.98 0.377 0.0177 1.07 1.4534 0.9991 1168222 Bionet1_003852 CN1c2ccccc2C(=C(C(=S)Nc3ccc(F)c(Cl)c3)S1(=O)=O)O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M15 compound treatment 0.39 0.0393 2.01 0.4 0.0407 2.46 3.1583 0.9949 1910436 Bionet1_003853 COC(=O)/C(=C\Nc1cc(F)ccc1F)/c2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M16 compound treatment 0.391 0.0403 2.06 0.389 0.0297 1.8 2.7249 0.9977 1910437 Bionet1_003854 Fc1cccc(Cl)c1CSC2=Nc3cc(Cl)ccc3SCC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M17 compound treatment 0.356 0.00525 0.27 0.372 0.0127 0.77 0.7337 0.9006 1910438 Bionet1_003855 COc1ccc(Cn2ccc(O)c(C/C=C/c3ccccc3)c2=O)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M18 compound treatment 0.38 0.0293 1.5 0.388 0.0287 1.74 2.2845 0.9973 1910439 Bionet1_003856 COc1ccc(CSC2=Nc3cc(Cl)ccc3SCC2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M19 compound treatment 0.38 0.0293 1.5 0.389 0.0297 1.8 2.3272 0.9959 1910440 Bionet1_003857 Oc1ccn(Cc2ccc(Cl)cc2Cl)c(=O)c1C/C=C/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M20 compound treatment 0.352 0.00125 0.06 0.363 0.00374 0.23 0.2049 0.8729 1910441 Bionet1_003858 FC(F)(F)c1cccc(CSC2=CS(=O)(=O)c3ccccc3N2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M21 compound treatment 0.359 0.00825 0.42 0.366 0.00674 0.41 0.5861 0.9998 1211240 Bionet1_003859 COc1ccc(NC(=O)CC2ON(C)C(=O)N2c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M22 compound treatment 0.373 0.0222 1.14 0.384 0.0247 1.49 1.8606 0.991 1280568 Bionet1_003860 CC(C)(C)c1ccc(CSC2=CS(=O)(=O)c3ccccc3N2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M23 positive control 0.091 -0.26 -13.28 0.089 -0.27 -16.32 -20.928 -0.9948 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 M24 positive control 0.095 -0.256 -13.08 0.096 -0.263 -15.89 -20.4846 -0.9953 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N01 mock treatment 0.349 -0.00175 -0.09 0.356 -0.00326 -0.2 -0.2023 -0.9364 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N02 mock treatment 0.36 0.00925 0.47 0.367 0.00774 0.47 0.6649 1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N03 compound treatment 0.357 0.00625 0.32 0.378 0.0187 1.13 1.026 0.8727 1910442 Bionet1_003861 CC(=O)Nc1ccc(cc1)S(=O)(=O)Oc2ccc(c(F)c2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N04 compound treatment 0.349 -0.00175 -0.09 0.358 -0.00126 -0.08 -0.117 -0.9967 1910443 Bionet1_003862 CN1N=C/2C(CN(Cc3ccccc3)C\C2=C/c4ccccc4)C1c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N05 compound treatment 0.349 -0.00175 -0.09 0.362 0.00274 0.17 0.0538 0.2858 1910444 Bionet1_003863 Fc1cc(OC(=O)c2cccc(Cl)c2Cl)ccc1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N06 compound treatment 0.43 0.0793 4.05 0.438 0.0787 4.75 6.2266 0.9968 1910445 Bionet1_003864 CN(C)/C=C\C(=O)c1nc2ccccc2n1Cc3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N07 compound treatment 0.341 -0.00975 -0.5 0.356 -0.00326 -0.2 -0.4916 -0.9173 1362335 Bionet1_003865 OC(c1cc2cc(Br)cc(Br)c2o1)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N08 compound treatment 0.359 0.00825 0.42 0.372 0.0127 0.77 0.8422 0.96 1219502 Bionet1_003866 COc1ccc(cc1)c2cn3cc(I)ccc3n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N09 compound treatment 0.35 -7.5E-4 -0.04 0.359 -2.58E-4 -0.02 -0.0381 -0.9212 1910446 Bionet1_003867 C/C(=N/NC(=O)c1cn(cn1)c2cccc(C)n2)/c3ccc(cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N10 compound treatment 0.353 0.00225 0.12 0.363 0.00374 0.23 0.2411 0.951 1910447 Bionet1_003868 Fc1ccccc1/C=C\2/C(OC(=O)c3c(F)cccc3F)C4CCN2CC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N11 compound treatment 0.357 0.00625 0.32 0.377 0.0177 1.07 0.9833 0.8798 1489529 Bionet1_003869 CC(Oc1ccc(c(F)c1)c2ccccc2)c3ccn(n3)C(=O)C4CCCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N12 compound treatment 0.394 0.0432 2.21 0.405 0.0457 2.76 3.5163 0.9939 1327990 Bionet1_003870 COC(=O)c1ccc(cc1OC(=O)c2ccccc2Cl)n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N13 compound treatment 0.374 0.0233 1.19 0.382 0.0227 1.37 1.8114 0.9974 1706126 Bionet1_003871 CCCc1ccc(c(F)c1)c2ccc(cc2)c3nocc3c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N14 compound treatment 0.375 0.0243 1.24 0.385 0.0257 1.55 1.9756 0.9937 1910448 Bionet1_003872 [O-][N+](=O)c1ccc(cc1)C(=O)OC/2C3CCN(CC3)\C2=C/c4ccccc4F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N15 compound treatment 0.351 2.5E-4 0.01 0.358 -0.00126 -0.08 -0.0447 -0.5799 1588140 Bionet1_003873 CCOC(=O)Cn1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N16 compound treatment 0.372 0.0213 1.09 0.37 0.0107 0.65 1.2269 0.9696 1361101 Bionet1_003874 COC(=O)c1cc(Br)c(NC(=O)c2cccs2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N17 compound treatment 0.353 0.00225 0.12 0.366 0.00674 0.41 0.3691 0.8728 1224039 Bionet1_003875 Oc1ccn(CCc2ccccc2)c(=O)c1Cc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N18 compound treatment 0.36 0.00925 0.47 0.357 -0.00226 -0.14 0.2381 0.4836 1910449 Bionet1_003876 Oc1ccn(CC(F)(F)F)c(=O)c1Cc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N19 compound treatment 0.35 -7.5E-4 -0.04 0.357 -0.00226 -0.14 -0.1235 -0.8722 1211376 Bionet1_003877 Oc1ccn(Cc2ccncc2)c(=O)c1Cc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N20 compound treatment 0.371 0.0203 1.04 0.374 0.0147 0.89 1.3614 0.9972 1712954 Bionet1_003878 CCC(=O)C(Cc1ccc(Cl)cc1Cl)c2ccnc3nc(N)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N21 compound treatment 0.385 0.0343 1.75 0.396 0.0367 2.22 2.8067 0.9932 1361337 Bionet1_003879 Oc1ccn(Cc2ccc(Cl)cc2)c(=O)c1Cc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N22 compound treatment 0.353 0.00225 0.12 0.356 -0.00326 -0.2 -0.0577 -0.2533 1626178 Bionet1_003880 Oc1nc2sc3ccccc3n2c(=O)c1C(=O)Nc4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N23 positive control 0.09 -0.261 -13.33 0.091 -0.268 -16.19 -20.8788 -0.9953 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 N24 positive control 0.093 -0.258 -13.18 0.095 -0.264 -15.95 -20.5996 -0.9955 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O01 mock treatment 0.361 0.0103 0.52 0.368 0.00874 0.53 0.7438 1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O02 mock treatment 0.359 0.00825 0.42 0.365 0.00574 0.35 0.5434 0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O03 compound treatment 0.367 0.0163 0.83 0.385 0.0257 1.55 1.6864 0.957 1910450 Bionet1_003881 Cc1ccc(N/C=C(/c2ccc(Cl)nc2)\S(=O)(=O)c3ccccc3)cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O04 compound treatment 0.356 0.00525 0.27 0.377 0.0177 1.07 0.9472 0.8578 1255091 Bionet1_003882 Clc1ccc(CSC2=CS(=O)(=O)c3ccccc3N2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O05 compound treatment 0.354 0.00325 0.17 0.374 0.0147 0.89 0.7468 0.8249 1910451 Bionet1_003883 FC(F)(F)c1ccc(cc1)C(=O)Nc2ccc(cc2)c3nc4ccccc4o3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O06 compound treatment 0.374 0.0233 1.19 0.391 0.0317 1.92 2.1956 0.9736 1910452 Bionet1_003884 Cn1c2sc(cc2c3ccccc13)C(=O)NNC(=O)c4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O07 compound treatment 0.379 0.0283 1.44 0.387 0.0277 1.67 2.2056 0.9973 1316690 Bionet1_003885 COc1ccc(Oc2ccc(cc2)c3nc(N)c(C#N)c(C#N)c3C#N)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O08 compound treatment 0.361 0.0103 0.52 0.363 0.00374 0.23 0.5303 0.9292 1910453 Bionet1_003886 CN1CCN(Cc2ccc(Sc3ccc(Cl)cc3)c(c2)[N+](=O)[O-])CC1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O09 compound treatment 0.36 0.00925 0.47 0.363 0.00374 0.23 0.4942 0.9428 3006735 Bionet1_003887 CN1CCOCC1.O=C1CC(C(=C(N1)[C-](C#N)C#N)C#N)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O10 compound treatment 0.375 0.0243 1.24 0.38 0.0207 1.25 1.7622 1.0 1910455 Bionet1_003888 [O-][N+](=O)c1cc(CN2CCOCC2)ccc1Sc3nc4ccccc4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O11 compound treatment 0.354 0.00325 0.17 0.365 0.00574 0.35 0.3626 0.9433 1910456 Bionet1_003889 OC(CN(Cc1ccc(Cl)cc1)C(=O)Nc2cccc(F)c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O12 compound treatment 0.36 0.00925 0.47 0.366 0.00674 0.41 0.6222 0.9972 1249045 Bionet1_003890 COC(=O)Cc1cc(OC)c(OC)cc1S(=O)(=O)N2CCOCC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O13 compound treatment 0.371 0.0203 1.04 0.382 0.0227 1.37 1.7029 0.9903 1141297 Bionet1_003891 Clc1ccc(cc1Cl)C(=O)Nc2ccc(cc2)c3nc4ccccc4o3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O14 compound treatment 0.364 0.0133 0.68 0.367 0.00774 0.47 0.8095 0.9836 1910457 Bionet1_003892 COC(=O)c1sccc1NC(=O)CN2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O15 compound treatment 0.388 0.0372 1.9 0.401 0.0417 2.52 3.1286 0.9905 1331590 Bionet1_003893 Clc1ccc(C(=O)Nc2ccc(cc2)c3nc4ccccc4o3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O16 compound treatment 0.375 0.0243 1.24 0.388 0.0287 1.74 2.1037 0.9864 1910458 Bionet1_003894 COC(=O)c1sccc1NC(=O)CN2CCN(CC2)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O17 compound treatment 0.374 0.0233 1.19 0.382 0.0227 1.37 1.8114 0.9974 1654630 Bionet1_003895 Clc1cccc(C(=O)Nc2ccc(cc2)c3nc4ccccc4o3)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O18 compound treatment 0.359 0.00825 0.42 0.366 0.00674 0.41 0.5861 0.9998 1704616 Bionet1_003896 COc1ccccc1C(=O)Nc2c(C#N)c(C)c(C)n2Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O19 compound treatment 0.366 0.0153 0.78 0.379 0.0197 1.19 1.3941 0.9789 1910459 Bionet1_003897 Brc1ccc(cc1)C(=O)CSc2nnc(o2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O20 compound treatment 0.362 0.0113 0.58 0.369 0.00974 0.59 0.8226 0.9999 1910460 Bionet1_003898 FC(F)(F)c1ccccc1c2nnc(o2)c3cc4CCc5ccccc5-c4s3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O21 compound treatment 0.364 0.0133 0.68 0.37 0.0107 0.65 0.9376 0.9998 1910461 Bionet1_003899 O=C(CSc1nnc(o1)c2ccccc2)c3ccc(cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O22 compound treatment 0.361 0.0103 0.52 0.369 0.00974 0.59 0.7865 0.9983 1910462 Bionet1_003900 Fc1ccc(CSc2nnc(o2)c3cc4CCc5ccccc5-c4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O23 positive control 0.09 -0.261 -13.33 0.091 -0.268 -16.19 -20.8788 -0.9953 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 O24 positive control 0.095 -0.256 -13.08 0.098 -0.261 -15.77 -20.3992 -0.9957 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P01 mock treatment 0.364 0.0133 0.68 0.379 0.0197 1.19 1.3218 0.9642 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P02 mock treatment 0.356 0.00525 0.27 0.369 0.00974 0.59 0.6057 0.9369 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P03 compound treatment 0.353 0.00225 0.12 0.359 -2.58E-4 -0.02 0.0703 0.6058 1739357 Bionet1_003901 Cn1cccc1C(=O)Nn2ccc(O)c(Cc3ccc(Cl)cc3Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P04 compound treatment 0.352 0.00125 0.06 0.351 -0.00826 -0.5 -0.3073 -0.6114 1687068 Bionet1_003902 Oc1nc2sc3ccccc3n2c(=O)c1C(=O)Nc4nc5ccccc5s4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P05 compound treatment 0.353 0.00225 0.12 0.371 0.0117 0.71 0.5826 0.8113 1910463 Bionet1_003903 CCOC(=O)C(Cc1ccc(Cl)cc1Cl)C(=O)/C=C/NCC(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P06 compound treatment 0.37 0.0193 0.98 0.368 0.00874 0.53 1.0692 0.9573 1910464 Bionet1_003904 FC(F)(F)c1cnc(CC(=O)NCc2ccc3OCOc3c2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P07 compound treatment 0.358 0.00725 0.37 0.362 0.00274 0.17 0.3792 0.934 1383151 Bionet1_003905 CN1OC(CC(=O)Nc2cc(C)on2)N(C1=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P08 compound treatment 0.364 0.0133 0.68 0.371 0.0117 0.71 0.9803 0.9997 1910465 Bionet1_003906 FC(F)(F)c1cccc(CNC(=O)Cc2ncc(cc2Cl)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P09 compound treatment 0.359 0.00825 0.42 0.367 0.00774 0.47 0.6288 0.9987 1470073 Bionet1_003907 CN1OC(CC(=O)NC2CCCCCC2)N(C1=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P10 compound treatment 0.359 0.00825 0.42 0.362 0.00274 0.17 0.4153 0.9165 1313971 Bionet1_003908 Oc1ccn(CCCN2CCOCC2)c(=O)c1Cc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P11 compound treatment 0.351 2.5E-4 0.01 0.363 0.00374 0.23 0.1688 0.7459 1546856 Bionet1_003909 CSc1cccc(c1)n2ccc(O)c(Cc3ccc(Cl)cc3Cl)c2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P12 compound treatment 0.391 0.0403 2.06 0.435 0.0757 4.57 4.6885 0.935 1910466 Bionet1_003910 CCSc1ncc(/C=N/Nc2c(Cl)cc(Cl)cc2Cl)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P13 compound treatment 0.362 0.0113 0.58 0.372 0.0127 0.77 0.9507 0.9898 1910467 Bionet1_003911 Fc1cccc(CSc2nnc(o2)c3ccc(cc3)C(F)(F)F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P14 compound treatment 0.394 0.0432 2.21 0.4 0.0407 2.46 3.3029 0.9986 1910468 Bionet1_003912 CCSc1ncc(/C=N/Nc2c(Cl)cc(cc2Cl)C(F)(F)F)n1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P15 compound treatment 0.351 2.5E-4 0.01 0.359 -2.58E-4 -0.02 -0.002 -0.0981 1910469 Bionet1_003913 FC(F)(F)c1ccc(cc1)c2nnc(SCCOc3ccccc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P16 compound treatment 0.392 0.0413 2.11 0.383 0.0237 1.43 2.5049 0.9823 1910470 Bionet1_003914 Clc1ccc(N/N=C/c2cnc(SCC=C)n2Cc3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P17 compound treatment 0.346 -0.00475 -0.24 0.351 -0.00826 -0.5 -0.5243 -0.9454 1910471 Bionet1_003915 COc1ccc(cc1)c2nnc(SCc3cccc(c3)C(F)(F)F)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P18 compound treatment 0.398 0.0473 2.42 0.397 0.0377 2.28 3.3195 0.9996 1401200 Bionet1_003916 CCS(=O)(=O)c1ccc(C(=O)Nc2ccccc2OC)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P19 compound treatment 0.352 0.00125 0.06 0.361 0.00174 0.11 0.1196 0.9715 1910472 Bionet1_003917 Fc1cccc(Cl)c1CSc2nnc(o2)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P20 compound treatment 0.361 0.0103 0.52 0.37 0.0107 0.65 0.8291 0.9944 1438845 Bionet1_003918 CCS(=O)(=O)c1ccc(C(=O)N2CCOCC2)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P21 compound treatment 0.355 0.00425 0.22 0.378 0.0187 1.13 0.9537 0.8278 1910473 Bionet1_003919 Cc1ccc(cc1)C(=O)CSc2nnc(o2)c3ccc(cc3)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P22 compound treatment 0.351 2.5E-4 0.01 0.346 -0.0133 -0.8 -0.5569 -0.6957 1424958 Bionet1_003920 CCS(=O)(=O)c1ccc(C(=O)Nc2cccc(Cl)c2)c(Cl)c1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P23 positive control 0.091 -0.26 -13.28 0.095 -0.264 -15.95 -20.6719 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.579 P24 positive control 0.094 -0.257 -13.13 0.103 -0.256 -15.47 -20.2219 -0.9967 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A01 mock treatment 0.32 -0.0346 -1.77 0.325 -0.0378 -2.28 -2.8669 -0.9921 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A02 mock treatment 0.319 -0.0356 -1.82 0.321 -0.0418 -2.53 -3.0738 -0.9871 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A03 compound treatment 0.336 -0.0186 -0.95 0.335 -0.0278 -1.68 -1.8615 -0.9638 1910703 Bionet1_004241 FC(F)(F)c1cccc(Oc2ccccc2/C=C\3/SC(=O)NC3=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A04 compound treatment 0.325 -0.0296 -1.51 0.325 -0.0378 -2.28 -2.6861 -0.9801 1910704 Bionet1_004242 Cc1ccc(CSc2nc(nnc2C(F)(F)F)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A05 compound treatment 0.33 -0.0246 -1.26 0.331 -0.0318 -1.92 -2.2492 -0.979 1910705 Bionet1_004243 FC(F)(F)c1ccccc1n2cc(nn2)C(=O)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A06 compound treatment 0.333 -0.0216 -1.11 0.331 -0.0318 -1.92 -2.1407 -0.9655 1910706 Bionet1_004244 FC(F)(F)c1ccc(cc1)C(=O)N2CCN(CC2)c3ccc(C#N)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A07 compound treatment 0.326 -0.0286 -1.46 0.338 -0.0248 -1.5 -2.095 -0.9999 1163461 Bionet1_004245 CN1CCN(CC1)c2ccc(cc2)C(=O)c3cn(nn3)c4ccc(C)c(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A08 compound treatment 0.326 -0.0286 -1.46 0.335 -0.0278 -1.68 -2.2231 -0.9976 1407957 Bionet1_004246 Clc1ccc(c(Cl)c1)S(=O)(=O)N2CCN(CC2)c3ccc(C#N)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A09 compound treatment 0.323 -0.0316 -1.62 0.322 -0.0408 -2.47 -2.8865 -0.9791 1910707 Bionet1_004247 FC(F)(F)C(CN1CCCCC1)OC(=O)Nc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A10 compound treatment 0.327 -0.0276 -1.41 0.327 -0.0358 -2.16 -2.5284 -0.9787 1206614 Bionet1_004248 Clc1cccc(c1Cl)S(=O)(=O)N2CCN(CC2)c3ccc(C#N)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A11 compound treatment 0.339 -0.0156 -0.8 0.335 -0.0278 -1.68 -1.7531 -0.9422 1910708 Bionet1_004249 Brc1ccc(CSC2=Nc3ccccc3C4=NC(=O)CN42)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A12 compound treatment 0.322 -0.0326 -1.67 0.327 -0.0358 -2.16 -2.7092 -0.9918 1315919 Bionet1_004250 Clc1ccc(cc1Cl)S(=O)(=O)N2CCN(CC2)c3ccc(C#N)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A13 compound treatment 0.336 -0.0186 -0.95 0.332 -0.0308 -1.86 -1.9896 -0.9516 1910709 Bionet1_004251 Clc1ccc(CSC2=Nc3ccccc3C4=NC(=O)CN42)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A14 compound treatment 0.326 -0.0286 -1.46 0.326 -0.0368 -2.22 -2.6073 -0.9794 1241057 Bionet1_004252 COc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccc(C#N)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A15 compound treatment 0.319 -0.0356 -1.82 0.332 -0.0308 -1.86 -2.6042 -0.9999 1910710 Bionet1_004253 FC(F)(F)c1nc2cc(Cl)c(Cl)cc2nc1C(C#N)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A16 compound treatment 0.33 -0.0246 -1.26 0.324 -0.0388 -2.34 -2.548 -0.9575 1426382 Bionet1_004254 Clc1ccc(CC(=O)c2cc(C#N)n(Cc3cccc(Cl)c3)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A17 compound treatment 0.325 -0.0296 -1.51 0.325 -0.0378 -2.28 -2.6861 -0.9801 1276216 Bionet1_004255 Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccc(C#N)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A18 compound treatment 0.334 -0.0206 -1.05 0.333 -0.0298 -1.8 -2.0192 -0.9675 1910711 Bionet1_004256 COc1cc2N=C(SCc3ccc(C)cc3)N4CC(=O)N=C4c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A19 compound treatment 0.334 -0.0206 -1.05 0.329 -0.0338 -2.04 -2.19 -0.9527 1910712 Bionet1_004257 Clc1ccc(cc1)C(=O)O/N=C/c2ccc(OCc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A20 compound treatment 0.335 -0.0196 -1.0 0.331 -0.0318 -1.92 -2.0684 -0.9541 1910713 Bionet1_004258 COc1cc2N=C(SCc3cccc(F)c3)N4CC(=O)N=C4c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A21 compound treatment 0.328 -0.0266 -1.36 0.334 -0.0288 -1.74 -2.1935 -0.9926 1910714 Bionet1_004259 FC(F)(F)c1ccc(cc1)C(=O)O/N=C/c2ccc(OCc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A22 compound treatment 0.334 -0.0206 -1.05 0.327 -0.0358 -2.16 -2.2753 -0.9455 1910715 Bionet1_004260 COc1cc2N=C(SCc3cccc(C)c3)N4CC(=O)N=C4c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A23 positive control 0.091 -0.264 -13.48 0.086 -0.277 -16.71 -21.3488 -0.9943 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 A24 positive control 0.093 -0.262 -13.38 0.089 -0.274 -16.53 -21.1484 -0.9945 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B01 mock treatment 0.354 -6.25E-4 -0.03 0.359 -0.00383 -0.23 -0.1862 -0.7972 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B02 mock treatment 0.357 0.00237 0.12 0.358 -0.00483 -0.29 -0.1204 -0.3811 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B03 compound treatment 0.352 -0.00263 -0.13 0.363 1.67E-4 0.01 -0.0878 -0.6523 1910716 Bionet1_004261 COc1ccccc1/C=C(\C(=O)NCc2ccc(F)cc2)/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B04 compound treatment 0.369 0.0144 0.74 0.378 0.0152 0.92 1.1672 0.9941 1910717 Bionet1_004262 Clc1cccc(COc2ccc(C=C3C(=O)NC(=O)NC3=O)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B05 compound treatment 0.422 0.0674 3.45 0.413 0.0502 3.03 4.5775 0.9979 1910718 Bionet1_004263 COc1cc(Br)cc(/C=N/c2ccc3nc(C)c(C)nc3c2)c1O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B06 compound treatment 0.395 0.0404 2.06 0.393 0.0302 1.82 2.7475 0.998 1689914 Bionet1_004264 Cc1ccc(COc2ccc(cc2)c3nccc(n3)c4cccs4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B07 compound treatment 0.373 0.0184 0.94 0.373 0.0102 0.61 1.0984 0.9787 1910719 Bionet1_004265 Cc1nc2ccc(NS(=O)(=O)c3cccc(c3)C(F)(F)F)cc2nc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B08 compound treatment 0.385 0.0304 1.55 0.394 0.0312 1.88 2.4286 0.9955 1910720 Bionet1_004266 CC(Oc1ccc(c(F)c1)c2ccccc2)c3ccn(n3)C(=O)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B09 compound treatment 0.356 0.00137 0.07 0.343 -0.0198 -1.2 -0.7969 -0.6644 1498604 Bionet1_004267 CCOC(=O)NC(C1CCCC(C(=O)OCC)C1=O)c2ccccc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B10 compound treatment 0.36 0.00537 0.27 0.36 -0.00283 -0.17 0.0734 0.2267 1544575 Bionet1_004268 COC(=O)Cc1c(O)ccn(CCc2ccc(cc2)S(=O)(=O)N)c1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B11 compound treatment 0.36 0.00537 0.27 0.354 -0.00883 -0.53 -0.1827 -0.3046 1910721 Bionet1_004269 COc1ccccc1/C=C(\C(=O)N2CCN(CC2)c3ccccc3)/c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B12 compound treatment 0.356 0.00137 0.07 0.365 0.00217 0.13 0.1422 0.9576 1910722 Bionet1_004270 COc1ccc(cc1)C2C(=C(N)Oc3c2c(C)nn3c4ccc(C)cc4)C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B13 compound treatment 0.357 0.00237 0.12 0.363 1.67E-4 0.01 0.093 0.7631 1910723 Bionet1_004271 COc1ccc(CNC(=O)/C(=C\c2ccccc2OC)/c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B14 compound treatment 0.361 0.00637 0.33 0.368 0.00517 0.31 0.451 0.9998 1910724 Bionet1_004272 COc1ccc(cc1)C2C(C#N)C(=O)Nc3c2c(C)nn3C4=NCCCN4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B15 compound treatment 0.354 -6.25E-4 -0.03 0.356 -0.00683 -0.41 -0.3143 -0.7596 1910725 Bionet1_004273 COc1ccccc1/C=C(\C(=O)NCc2ccc(C)cc2)/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B16 compound treatment 0.354 -6.25E-4 -0.03 0.358 -0.00483 -0.29 -0.2289 -0.7799 1910726 Bionet1_004274 Cc1nc(sc1C(=O)/C=C/c2ccc(Cl)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B17 compound treatment 0.359 0.00437 0.22 0.362 -8.33E-4 -0.05 0.1226 0.5347 1910727 Bionet1_004275 COc1ccccc1/C=C(/C(=O)NCCCn2ccnc2)\c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B18 compound treatment 0.359 0.00437 0.22 0.356 -0.00683 -0.41 -0.1335 -0.2845 1910728 Bionet1_004276 Cc1nn2c(cc(nc2c1Br)c3ccccc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B19 compound treatment 0.358 0.00337 0.17 0.36 -0.00283 -0.17 0.0011 0.0044 1910729 Bionet1_004277 Clc1ccc(cc1)C(=O)NNC(=O)C2Cc3c(O2)ccc4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B20 compound treatment 0.364 0.00937 0.48 0.359 -0.00383 -0.23 0.1753 0.3294 1910730 Bionet1_004278 Fc1ccc(CNC(=O)/C=C/c2cc3OCOc3cc2Br)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B21 compound treatment 0.357 0.00237 0.12 0.364 0.00117 0.07 0.1357 0.9664 1910731 Bionet1_004279 Cc1ccc(cc1)S(=O)(=O)NNC(=O)C2Cc3c(O2)ccc4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B22 compound treatment 0.362 0.00737 0.38 0.365 0.00217 0.13 0.3591 0.8998 1910732 Bionet1_004280 COc1ccc(CNC(=O)/C=C/c2cc3OCOc3cc2Br)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B23 positive control 0.089 -0.266 -13.58 0.088 -0.275 -16.59 -21.3357 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 B24 positive control 0.093 -0.262 -13.38 0.09 -0.273 -16.47 -21.1057 -0.9947 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C01 mock treatment 0.353 -0.00163 -0.08 0.358 -0.00483 -0.29 -0.2651 -0.8737 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C02 mock treatment 0.368 0.0134 0.68 0.364 0.00117 0.07 0.5334 0.7758 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C03 compound treatment 0.368 0.0134 0.68 0.37 0.00717 0.43 0.7895 0.9756 1233450 Bionet1_004281 CCOC(=O)c1c(C)nn(c1C)c2ccc(NC(=O)Nc3ccccc3)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C04 compound treatment 0.387 0.0324 1.66 0.389 0.0262 1.58 2.2875 0.9997 1910733 Bionet1_004282 COc1cc2N=C(SCC(=O)OC(C)(C)C)N3CC(=O)N=C3c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C05 compound treatment 0.36 0.00537 0.27 0.355 -0.00783 -0.47 -0.14 -0.256 1267560 Bionet1_004283 CCOC(=O)c1c(C)nn(c1C)c2ccc(NC(=O)Nc3ccc(C)cc3)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C06 compound treatment 0.319 -0.0356 -1.82 0.354 -0.00883 -0.53 -1.6651 -0.8773 1910734 Bionet1_004284 COc1cc2N=C(SCc3ccccc3)N4CC(=O)N=C4c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C07 compound treatment 0.377 0.0224 1.14 0.381 0.0182 1.1 1.5845 0.9998 1910735 Bionet1_004285 COc1ccc(cc1)C(=O)O/N=C/c2ccc(OCc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C08 compound treatment 0.352 -0.00263 -0.13 0.365 0.00217 0.13 -0.0024 -0.0129 1910736 Bionet1_004286 FC(F)(F)c1cccc(c1)C(=O)N2CCN(CC2)c3ccc(C#N)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C09 compound treatment 0.358 0.00337 0.17 0.363 1.67E-4 0.01 0.1291 0.7471 1910737 Bionet1_004287 Cc1ccc(N/C=C/C(=O)c2ccccc2OCc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C10 compound treatment 0.355 3.75E-4 0.02 0.371 0.00817 0.49 0.3622 0.7341 1430967 Bionet1_004288 Fc1cccc(Cl)c1Cn2cc(cc2C#N)C(=O)Cc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C11 compound treatment 0.353 -0.00163 -0.08 0.358 -0.00483 -0.29 -0.2651 -0.8737 1212717 Bionet1_004289 CCOC(=O)c1ccc(cc1)n2cc(nn2)C(=O)c3ccc(cc3)n4ccnc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C12 compound treatment 0.346 -0.00863 -0.44 0.359 -0.00383 -0.23 -0.4755 -0.9547 1741576 Bionet1_004290 Clc1cc(Cl)cc(Oc2nc3ccccc3nc2Cc4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C13 compound treatment 0.358 0.00337 0.17 0.35 -0.0128 -0.77 -0.4258 -0.5365 1910738 Bionet1_004291 Cc1ccc(/C=N/NC(=O)c2sc3nc(C)cc(C)c3c2n4cccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C14 compound treatment 0.374 0.0194 0.99 0.385 0.0222 1.34 1.6467 0.9891 1910739 Bionet1_004292 [O-][N+](=O)c1ccc(C/2CCCC\C2=N\Nc3cccc(F)n3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C15 compound treatment 0.355 3.75E-4 0.02 0.361 -0.00183 -0.11 -0.0647 -0.576 1541859 Bionet1_004293 Clc1ccccc1Cn2nc(c3ccccc3)c(cc2=O)N4CCCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C16 compound treatment 0.351 -0.00363 -0.19 0.364 0.00117 0.07 -0.0813 -0.4098 1910740 Bionet1_004294 [O-][N+](=O)c1ccc(C/2CCCC\C2=N\Nc3cccc(Cl)n3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C17 compound treatment 0.348 -0.00663 -0.34 0.357 -0.00583 -0.35 -0.4885 -0.9998 1166194 Bionet1_004295 Cc1ccc(SCC2(O)CCN(CC2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C18 compound treatment 0.35 -0.00463 -0.24 0.356 -0.00683 -0.41 -0.4589 -0.9651 1910741 Bionet1_004296 [O-][N+](=O)c1ccc(C/2CCCC\C2=N\Nc3ccccc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C19 compound treatment 0.361 0.00637 0.33 0.361 -0.00183 -0.11 0.1522 0.4422 1652199 Bionet1_004297 Fc1ccc(Cn2nc(c3ccccc3)c(cc2=O)N4CCCCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C20 compound treatment 0.364 0.00937 0.48 0.37 0.00717 0.43 0.6449 0.9987 1234234 Bionet1_004298 Brc1ccccc1C(=O)c2c[nH]c(c2)C(=O)NC3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C21 compound treatment 0.362 0.00737 0.38 0.365 0.00217 0.13 0.3591 0.8998 1492477 Bionet1_004299 Cc1cccc(Cn2nc(c3ccccc3)c(cc2=O)N4CCCCC4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C22 compound treatment 0.358 0.00337 0.17 0.361 -0.00183 -0.11 0.0438 0.2135 1910742 Bionet1_004300 FC(F)(F)C(=O)/C=C/N1CCN(CC1)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C23 positive control 0.086 -0.269 -13.74 0.085 -0.278 -16.77 -21.5723 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 C24 positive control 0.09 -0.265 -13.53 0.092 -0.271 -16.35 -21.1288 -0.9956 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D01 mock treatment 0.346 -0.00863 -0.44 0.356 -0.00683 -0.41 -0.6035 -0.9994 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D02 mock treatment 0.352 -0.00263 -0.13 0.353 -0.00983 -0.59 -0.5147 -0.8456 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D03 compound treatment 0.343 -0.0116 -0.59 0.349 -0.0138 -0.84 -1.0108 -0.9861 1910743 Bionet1_004301 COc1ccccc1/C=C(/C(=O)NCCc2ccccc2)\c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D04 compound treatment 0.349 -0.00563 -0.29 0.354 -0.00883 -0.53 -0.5804 -0.958 1910744 Bionet1_004302 Cc1ccc(N/C=C/C(=O)c2cnc(s2)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D05 compound treatment 0.369 0.0144 0.74 0.371 0.00817 0.49 0.8684 0.9811 1910745 Bionet1_004303 COc1ccc(cc1)S(=O)(=O)NNC(=O)C2Cc3c(O2)ccc4ccccc34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D06 compound treatment 0.35 -0.00463 -0.24 0.359 -0.00383 -0.23 -0.3309 -0.9999 1910746 Bionet1_004304 COc1ccc(Oc2nc3cc(Cl)c(Cl)cc3nc2C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D07 compound treatment 0.386 0.0314 1.6 0.393 0.0302 1.82 2.4221 0.998 1910747 Bionet1_004305 Fc1ccc(/C=N/Nc2nc3ccccc3nc2Cc4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D08 compound treatment 0.372 0.0174 0.89 0.383 0.0202 1.22 1.4891 0.988 1119539 Bionet1_004306 COc1ccc(cc1)c2ccnc(n2)c3ccc(OCc4cccc(F)c4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D09 compound treatment 0.347 -0.00763 -0.39 0.354 -0.00883 -0.53 -0.6528 -0.9882 1910748 Bionet1_004307 COCCN1C(=O)NC(=O)/C(=C\c2ccc(Br)cc2)/C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D10 compound treatment 0.342 -0.0126 -0.65 0.343 -0.0198 -1.2 -1.3031 -0.958 1910749 Bionet1_004308 CN(C)CCCNC(=O)c1cc(c[nH]1)C(=O)c2cccc(Cl)c2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D11 compound treatment 0.353 -0.00163 -0.08 0.359 -0.00383 -0.23 -0.2224 -0.9045 1910750 Bionet1_004309 CCc1cc(=O)[nH]c(SCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D12 compound treatment 0.35 -0.00463 -0.24 0.347 -0.0158 -0.96 -0.8431 -0.8562 1389266 Bionet1_004310 O=C(COc1ccc(cc1)c2nccc(n2)c3ccccn3)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D13 compound treatment 0.345 -0.00963 -0.49 0.351 -0.0118 -0.71 -0.8531 -0.9835 1259631 Bionet1_004311 COc1ccc(NC(=O)c2ccc(cc2)N3CCS(=O)(=O)CC3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D14 compound treatment 0.36 0.00537 0.27 0.351 -0.0118 -0.71 -0.3108 -0.406 1910751 Bionet1_004312 COCCCNC(=O)COc1ccc(cc1)c2nccc(n2)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D15 compound treatment 0.343 -0.0116 -0.59 0.345 -0.0178 -1.08 -1.1816 -0.9608 1910752 Bionet1_004313 CCOC(=O)c1cnn2c(C)c(Cc3c(Cl)cccc3Cl)c(C)nc12 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D16 compound treatment 0.358 0.00337 0.17 0.357 -0.00583 -0.35 -0.127 -0.3238 1910753 Bionet1_004314 CC(=O)Oc1c(C(=O)C)c2ccccn2c1c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D17 compound treatment 0.356 0.00137 0.07 0.36 -0.00283 -0.17 -0.0712 -0.3852 1910754 Bionet1_004315 CC(=O)c1ccccc1N/C=C/C(=O)c2ccc(Oc3ccccc3)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D18 compound treatment 0.351 -0.00363 -0.19 0.349 -0.0138 -0.84 -0.7216 -0.8435 1671266 Bionet1_004316 O=C1C2(CC2c3ccccc3)CN(Cc4ccccc4)CC51CC5c6ccccc6 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D19 compound treatment 0.35 -0.00463 -0.24 0.348 -0.0148 -0.9 -0.8004 -0.8642 1426932 Bionet1_004317 CCOC(=O)c1cnc2ccc(C)cc2c1Sc3ccccc3C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D20 compound treatment 0.355 3.75E-4 0.02 0.358 -0.00483 -0.29 -0.1928 -0.6592 1439112 Bionet1_004318 CCOC(=O)c1c(C)nn(c1C)c2ccc(NC(=O)c3cccs3)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D21 compound treatment 0.363 0.00837 0.43 0.353 -0.00983 -0.59 -0.1169 -0.1598 1910755 Bionet1_004319 CCOC(=O)c1cnc2c(F)cccc2c1Oc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D22 compound treatment 0.353 -0.00163 -0.08 0.352 -0.0108 -0.65 -0.5212 -0.7906 1397683 Bionet1_004320 CCOC(=O)c1c(C)nn(c1C)c2ccc(NC(=O)c3c(F)cccc3F)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D23 positive control 0.087 -0.268 -13.68 0.086 -0.277 -16.71 -21.4934 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 D24 positive control 0.091 -0.264 -13.48 0.092 -0.271 -16.35 -21.0927 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E01 mock treatment 0.351 -0.00363 -0.19 0.359 -0.00383 -0.23 -0.2947 -0.9939 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E02 mock treatment 0.362 0.00737 0.38 0.363 1.67E-4 0.01 0.2738 0.7257 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E03 compound treatment 0.352 -0.00263 -0.13 0.381 0.0182 1.1 0.6806 0.616 1910756 Bionet1_004321 COc1cnc(nc1Oc2ccc(Cl)c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E04 compound treatment 0.368 0.0134 0.68 0.366 0.00317 0.19 0.6188 0.8714 1910757 Bionet1_004322 Clc1ncc(COc2ccc3ccccc3c2C=C(C#N)C#N)s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E05 compound treatment 0.348 -0.00663 -0.34 0.356 -0.00683 -0.41 -0.5312 -0.9952 1210306 Bionet1_004323 OC1(CSc2ccccc2)CCN(CC1)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E06 compound treatment 0.358 0.00337 0.17 0.374 0.0112 0.67 0.5987 0.8604 1148614 Bionet1_004324 CC(Oc1ccc(c(F)c1)c2ccccc2)c3ccn(n3)C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E07 compound treatment 0.351 -0.00363 -0.19 0.316 -0.0468 -2.83 -2.1302 -0.7519 1590913 Bionet1_004325 OC1(CSc2ccc(F)cc2)CCN(CC1)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E08 compound treatment 0.36 0.00537 0.27 0.367 0.00417 0.25 0.3722 0.999 1910758 Bionet1_004326 Cc1ccc(cc1)c2ccnc(n2)c3ccc(OCc4ccc(cc4)[N+](=O)[O-])cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E09 compound treatment 0.362 0.00737 0.38 0.366 0.00317 0.19 0.4018 0.9504 1349748 Bionet1_004327 OC1(CN2CCOCC2)CCN(CC1)S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E10 compound treatment 0.36 0.00537 0.27 0.374 0.0112 0.67 0.671 0.9217 1910759 Bionet1_004328 Cc1nc(sc1C(=O)CC(C(C#N)C#N)c2ccccc2)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E11 compound treatment 0.348 -0.00663 -0.34 0.353 -0.00983 -0.59 -0.6593 -0.9646 1372261 Bionet1_004329 CN1CCN(CC2(O)CCN(CC2)S(=O)(=O)c3ccc(Cl)cc3)CC1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E12 compound treatment 0.352 -0.00263 -0.13 0.362 -8.33E-4 -0.05 -0.1305 -0.9103 1910760 Bionet1_004330 FC(F)(F)c1cc(cc(c1)C(F)(F)F)n2cc(nn2)C(=O)c3ccco3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E13 compound treatment 0.354 -6.25E-4 -0.03 0.362 -8.33E-4 -0.05 -0.0582 -0.976 1274041 Bionet1_004331 Cc1cc(C)c(C#N)c(Sc2ccccc2NC(=O)c3cccs3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E14 compound treatment 0.354 -6.25E-4 -0.03 0.36 -0.00283 -0.17 -0.1435 -0.8249 1910761 Bionet1_004332 Cc1c(nnn1c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccncc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E15 compound treatment 0.352 -0.00263 -0.13 0.357 -0.00583 -0.35 -0.3439 -0.9126 1251569 Bionet1_004333 Cc1cc(C)c(C#N)c(Sc2ccccc2NC(=O)c3ccc(F)cc3)n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E16 compound treatment 0.379 0.0244 1.25 0.39 0.0272 1.64 2.041 0.9908 1137482 Bionet1_004334 CC(Oc1ccc(c(F)c1)c2ccccc2)c3ccn(n3)C(=O)c4ccc(C)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E17 compound treatment 0.349 -0.00563 -0.29 0.362 -8.33E-4 -0.05 -0.239 -0.8184 1611768 Bionet1_004335 COc1cccc(c1)C(=O)Nc2ccccc2Sc3nc(C)cc(C)c3C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E18 compound treatment 0.359 0.00437 0.22 0.362 -8.33E-4 -0.05 0.1226 0.5347 1910762 Bionet1_004336 FCCCOc1ccc(cc1)c2nccc(n2)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E19 compound treatment 0.361 0.00637 0.33 0.372 0.00917 0.55 0.6218 0.9681 1372524 Bionet1_004337 Cc1cccc(c1)C(=O)Nc2ccccc2Sc3nc(C)cc(C)c3C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E20 compound treatment 0.365 0.0104 0.53 0.369 0.00617 0.37 0.6384 0.985 1262404 Bionet1_004338 CC(Oc1ccc(c(F)c1)c2ccccc2)c3ccn(n3)C(=O)c4ccco4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E21 compound treatment 0.365 0.0104 0.53 0.325 -0.0378 -2.28 -1.2399 -0.5288 1200589 Bionet1_004339 Cn1nc(c(c1Cl)c2nc(no2)c3ccccc3Cl)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E22 compound treatment 0.358 0.00337 0.17 0.367 0.00417 0.25 0.2999 0.9831 1910763 Bionet1_004340 FCCCOc1ccc(cc1)c2nccc(n2)c3ccc(cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E23 positive control 0.087 -0.268 -13.68 0.086 -0.277 -16.71 -21.4934 -0.9951 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 E24 positive control 0.093 -0.262 -13.38 0.095 -0.268 -16.17 -20.8923 -0.9956 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F01 mock treatment 0.349 -0.00563 -0.29 0.359 -0.00383 -0.23 -0.367 -0.9942 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F02 mock treatment 0.361 0.00637 0.33 0.366 0.00317 0.19 0.3657 0.9677 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F03 compound treatment 0.362 0.00737 0.38 0.365 0.00217 0.13 0.3591 0.8998 1536260 Bionet1_004341 CCOC(=O)c1cnc2c(F)cccc2c1Oc3ccccc3C(=O)OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F04 compound treatment 0.355 3.75E-4 0.02 0.364 0.00117 0.07 0.0634 0.868 1311426 Bionet1_004342 CCOC(=O)c1c(C)nn(c1C)c2ccc(NC(=O)c3ccco3)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F05 compound treatment 0.329 -0.0256 -1.31 0.353 -0.00983 -0.59 -1.3463 -0.9359 1910764 Bionet1_004343 COC(=O)c1cc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc2s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F06 compound treatment 0.377 0.0224 1.14 0.396 0.0332 2.0 2.2248 0.9648 1492508 Bionet1_004344 COC(=O)C1=C(C)NC(=C(C1c2ccc3ccccc3n2)C(=O)OC)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F07 compound treatment 0.339 -0.0156 -0.8 0.35 -0.0128 -0.77 -1.1128 -0.9999 1910765 Bionet1_004345 COC(=O)c1cc2cc(NS(=O)(=O)Cc3ccccc3)ccc2s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F08 compound treatment 0.374 0.0194 0.99 0.383 0.0202 1.22 1.5614 0.9948 1910766 Bionet1_004346 Brc1cc2OCOc2cc1/C=C/C(=O)NCc3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F09 compound treatment 0.379 0.0244 1.25 0.385 0.0222 1.34 1.8275 0.9994 1910767 Bionet1_004347 COC(=O)c1cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2s1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F10 compound treatment 0.333 -0.0216 -1.11 0.372 0.00917 0.55 -0.3906 -0.3159 1910768 Bionet1_004348 COCCCNC(=O)c1cc(c[nH]1)C(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F11 compound treatment 0.368 0.0134 0.68 0.367 0.00417 0.25 0.6614 0.9077 1601368 Bionet1_004349 COC(=O)C(C)Oc1ccc(cc1)c2nccc(n2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F12 compound treatment 0.355 3.75E-4 0.02 0.383 0.0202 1.22 0.8744 0.7182 1910769 Bionet1_004350 Clc1ccc(NC(=O)NNC(=O)C2CC(=NO2)c3cccnc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F13 compound treatment 0.382 0.0274 1.4 0.38 0.0172 1.04 1.7226 0.9891 1910770 Bionet1_004351 COC(=O)CCCOc1ccc(cc1)c2nccc(n2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F14 compound treatment 0.374 0.0194 0.99 0.374 0.0112 0.67 1.1772 0.9824 1910771 Bionet1_004352 Cc1ccc(/C=C/2\S/C(=N\n3cnnc3)/N(C2=O)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F15 compound treatment 0.395 0.0404 2.06 0.39 0.0272 1.64 2.6195 0.9935 1262536 Bionet1_004353 COc1ccc(cc1)c2nnc3SCC(=Nn23)c4ccc(Cl)cc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F16 compound treatment 0.374 0.0194 0.99 0.37 0.00717 0.43 1.0064 0.931 1910772 Bionet1_004354 CCCCCCCNC(=O)c1cc(c[nH]1)C(=O)c2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F17 compound treatment 0.359 0.00437 0.22 0.371 0.00817 0.49 0.5068 0.9361 1593127 Bionet1_004355 Cc1nnc(COc2cccc3n(ccc23)S(=O)(=O)c4ccc(C)cc4)o1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F18 compound treatment 0.37 0.0154 0.79 0.366 0.00317 0.19 0.6911 0.8542 1910773 Bionet1_004356 Clc1ccccc1NC(=O)NNC(=O)C2CC(=NO2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F19 compound treatment 0.371 0.0164 0.84 0.38 0.0172 1.04 1.3248 0.9944 1910774 Bionet1_004357 Cc1ccc(cc1)C(=O)CSc2nnc(o2)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F20 compound treatment 0.381 0.0264 1.35 0.387 0.0242 1.46 1.9852 0.9992 1910775 Bionet1_004358 FC(F)(F)c1cccc(c1)C(=O)c2c[nH]c(c2)C(=O)NCc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F21 compound treatment 0.356 0.00137 0.07 0.359 -0.00383 -0.23 -0.1139 -0.471 1910776 Bionet1_004359 FC(F)(F)c1cccc(Oc2ccccc2C=C3C(=O)NC(=O)NC3=O)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F22 compound treatment 0.366 0.0114 0.58 0.362 -8.33E-4 -0.05 0.3757 0.6435 1910777 Bionet1_004360 COc1ccc(NC(=O)NNC(=O)C2CC(=NO2)c3cccnc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F23 positive control 0.09 -0.265 -13.53 0.088 -0.275 -16.59 -21.2996 -0.9949 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 F24 positive control 0.094 -0.261 -13.33 0.094 -0.269 -16.23 -20.8988 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G01 mock treatment 0.339 -0.0156 -0.8 0.357 -0.00583 -0.35 -0.8139 -0.9322 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G02 mock treatment 0.351 -0.00363 -0.19 0.354 -0.00883 -0.53 -0.5081 -0.9001 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G03 compound treatment 0.354 -6.25E-4 -0.03 0.359 -0.00383 -0.23 -0.1862 -0.7972 1412425 Bionet1_004361 Cn1nc(c(c1Cl)c2nc(no2)c3cccc(Cl)c3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G04 compound treatment 0.366 0.0114 0.58 0.372 0.00917 0.55 0.8026 0.9997 1910778 Bionet1_004362 Cn1cccc1c2nnc(SCc3ccc(Br)cc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G05 compound treatment 0.369 0.0144 0.74 0.364 0.00117 0.07 0.5695 0.7713 1910779 Bionet1_004363 Cn1nc(c(c1Cl)c2nc(no2)c3ccc(Cl)cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G06 compound treatment 0.361 0.00637 0.33 0.372 0.00917 0.55 0.6218 0.9681 1910780 Bionet1_004364 COc1ccc(cc1)C(=O)CSc2nnc(o2)c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G07 compound treatment 0.341 -0.0136 -0.7 0.355 -0.00783 -0.47 -0.827 -0.9822 1202055 Bionet1_004365 Cc1ccc(OC(=O)CN(c2ccccc2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G08 compound treatment 0.349 -0.00563 -0.29 0.361 -0.00183 -0.11 -0.2816 -0.9139 1910781 Bionet1_004366 COc1ccc(cc1)c2nnc(SCc3ccc(cc3)C(F)(F)F)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G09 compound treatment 0.338 -0.0166 -0.85 0.35 -0.0128 -0.77 -1.1489 -0.9989 1443924 Bionet1_004367 Fc1ccc(OC(=O)CN(c2ccccc2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G10 compound treatment 0.387 0.0324 1.66 0.38 0.0172 1.04 1.9033 0.9746 1910782 Bionet1_004368 COc1ccc(cc1)c2nnc(SCC(=O)c3ccc(Cl)cc3Cl)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G11 compound treatment 0.336 -0.0186 -0.95 0.356 -0.00683 -0.41 -0.9651 -0.9299 1910783 Bionet1_004369 N/C(=N\OC(=O)c1ccccc1C(F)(F)F)/CS(=O)(=O)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G12 compound treatment 0.363 0.00837 0.43 0.367 0.00417 0.25 0.4807 0.9678 1390277 Bionet1_004370 CCOC(=O)COc1ccc(cc1)c2nccc(n2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G13 compound treatment 0.343 -0.0116 -0.59 0.357 -0.00583 -0.35 -0.6693 -0.9688 1910784 Bionet1_004371 FC(F)(F)c1ccccc1C(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G14 compound treatment 0.354 -6.25E-4 -0.03 0.355 -0.00783 -0.47 -0.357 -0.7532 1910785 Bionet1_004372 OC(CN1CCN(CC1)c2ncc(cc2Cl)C(F)(F)F)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G15 compound treatment 0.347 -0.00763 -0.39 0.359 -0.00383 -0.23 -0.4393 -0.969 1910786 Bionet1_004373 FC(F)(F)c1cccc(c1)C(=O)NNC(=O)c2sccc2n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G16 compound treatment 0.356 0.00137 0.07 0.367 0.00417 0.25 0.2276 0.8714 1910787 Bionet1_004374 COc1ccc(/C=C/C(OC(=O)Nc2cccc(F)c2)c3ccccn3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G17 compound treatment 0.355 3.75E-4 0.02 0.363 1.67E-4 0.01 0.0207 0.9547 1471906 Bionet1_004375 COc1ccccc1NC(=O)c2nn(ccc2=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G18 compound treatment 0.378 0.0234 1.2 0.379 0.0162 0.98 1.5353 0.9949 1910788 Bionet1_004376 COC(=O)CCCSC1=Nc2cc(OC)c(OC)cc2C3=NC(=O)CN31 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G19 compound treatment 0.372 0.0174 0.89 0.39 0.0272 1.64 1.7879 0.9585 1910789 Bionet1_004377 COc1ccccc1NC(=O)c2nn(ccc2=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G20 compound treatment 0.369 0.0144 0.74 0.375 0.0122 0.73 1.0391 1.0 1910790 Bionet1_004378 COc1cc2NC(=S)N3C(Cc4ccccc4)C(=O)N=C3c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G21 compound treatment 0.356 0.00137 0.07 0.361 -0.00183 -0.11 -0.0285 -0.2177 1502411 Bionet1_004379 COc1ccccc1NC(=O)c2nn(ccc2=O)c3ccc(F)c(F)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G22 compound treatment 0.354 -6.25E-4 -0.03 0.352 -0.0108 -0.65 -0.485 -0.7408 1910791 Bionet1_004380 Cc1ccc(cc1)C(=O)NNC(=O)C2CCN(Cc3ccccc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G23 positive control 0.09 -0.265 -13.53 0.088 -0.275 -16.59 -21.2996 -0.9949 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 G24 positive control 0.097 -0.258 -13.17 0.095 -0.268 -16.17 -20.7477 -0.9948 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H01 mock treatment 0.354 -6.25E-4 -0.03 0.364 0.00117 0.07 0.0272 0.3517 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H02 mock treatment 0.36 0.00537 0.27 0.358 -0.00483 -0.29 -0.012 -0.0299 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H03 compound treatment 0.361 0.00637 0.33 0.371 0.00817 0.49 0.5791 0.9798 1910792 Bionet1_004381 Cc1ccc(cc1)C2=Nn3c(nnc3SC2)c4ccc(cc4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H04 compound treatment 0.358 0.00337 0.17 0.362 -8.33E-4 -0.05 0.0865 0.481 1720607 Bionet1_004382 O=C(C1Cc2c(O1)ccc3ccccc23)N4CCN(CC4)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H05 compound treatment 0.394 0.0394 2.01 0.397 0.0342 2.06 2.8821 0.9999 1910793 Bionet1_004383 O=C(Oc1ccc(cc1)c2nccc(n2)c3ccccn3)c4cccs4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H06 compound treatment 0.363 0.00837 0.43 0.37 0.00717 0.43 0.6087 1.0 1529856 Bionet1_004384 CC(C)(C)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCC3CCCO3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H07 compound treatment 0.411 0.0564 2.88 0.406 0.0432 2.61 3.8809 0.9987 1422956 Bionet1_004385 Cc1nc(sc1C(=O)COc2ccc(Cl)c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H08 compound treatment 0.362 0.00737 0.38 0.379 0.0162 0.98 0.9568 0.9144 1440387 Bionet1_004386 CC(C)(C)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCc3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H09 compound treatment 0.343 -0.0116 -0.59 0.366 0.00317 0.19 -0.2851 -0.4567 1126110 Bionet1_004387 CCn1c(S)nnc1C2CCN(CC2)S(=O)(=O)c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H10 compound treatment 0.358 0.00337 0.17 0.368 0.00517 0.31 0.3426 0.961 1910794 Bionet1_004388 Clc1ccccc1CNC(=O)/C=C/c2cc3OCOc3cc2Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H11 compound treatment 0.344 -0.0106 -0.54 0.353 -0.00983 -0.59 -0.8039 -0.999 1910795 Bionet1_004389 NC(=O)C1(CCN(CC1)c2ccc(cn2)C(F)(F)F)N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H12 compound treatment 0.351 -0.00363 -0.19 0.34 -0.0228 -1.38 -1.1057 -0.795 1910796 Bionet1_004390 FC(F)(F)c1cccc(CNC(=O)C2Cc3c(O2)ccc4ccccc34)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H13 compound treatment 0.355 3.75E-4 0.02 0.346 -0.0168 -1.02 -0.705 -0.6936 1910797 Bionet1_004391 NC(=O)C1(CCN(CC1)c2ncc(cc2Cl)C(F)(F)F)N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H14 compound treatment 0.384 0.0294 1.5 0.38 0.0172 1.04 1.7949 0.9836 1910798 Bionet1_004392 Clc1ccc(CNC(=O)/C=C/c2cc3OCOc3cc2Br)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H15 compound treatment 0.379 0.0244 1.25 0.368 0.00517 0.31 1.1019 0.8576 1742891 Bionet1_004393 CCn1c(SC)nnc1C2CCN(CC2)S(=O)(=O)c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H16 compound treatment 0.355 3.75E-4 0.02 0.36 -0.00283 -0.17 -0.1074 -0.6239 1910799 Bionet1_004394 Clc1ccc(CN2CCC(CC2)C(=O)NNC(=O)C3CC3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H17 compound treatment 0.391 0.0364 1.86 0.391 0.0282 1.7 2.5175 0.999 1910800 Bionet1_004395 COc1cccc(c1)C(=O)Nc2ccc3sc4ccccc4c(=O)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H18 compound treatment 0.377 0.0224 1.14 0.375 0.0122 0.73 1.3283 0.977 1253700 Bionet1_004396 CC(C)(C)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCc3ccco3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H19 compound treatment 0.375 0.0204 1.04 0.371 0.00817 0.49 1.0853 0.9416 1910801 Bionet1_004397 CCOC(=O)c1cnc2ccc(cc2c1NCc3ccc(OC)cc3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H20 compound treatment 0.356 0.00137 0.07 0.358 -0.00483 -0.29 -0.1566 -0.5218 1910802 Bionet1_004398 CCCCN(CCCC)C(=O)c1cc(c[nH]1)C(=O)c2ccc(cc2)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H21 compound treatment 0.365 0.0104 0.53 0.372 0.00917 0.55 0.7664 0.9998 1193957 Bionet1_004399 Nc1c(C#N)c(Oc2ccc3ccccc3c2)sc1C(=O)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H22 compound treatment 0.361 0.00637 0.33 0.361 -0.00183 -0.11 0.1522 0.4422 1910803 Bionet1_004400 Fc1ccc(cc1)S(=O)(=O)NNC(=O)C2CC(=NO2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H23 positive control 0.094 -0.261 -13.33 0.088 -0.275 -16.59 -21.1549 -0.9941 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 H24 positive control 0.096 -0.259 -13.22 0.097 -0.266 -16.05 -20.6984 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I01 mock treatment 0.347 -0.00763 -0.39 0.357 -0.00583 -0.35 -0.5247 -0.9987 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I02 mock treatment 0.359 0.00437 0.22 0.36 -0.00283 -0.17 0.0372 0.1322 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I03 compound treatment 0.385 0.0304 1.55 0.381 0.0182 1.1 1.8737 0.9855 1910804 Bionet1_004401 Cc1ccccc1NC(=O)c2nn(ccc2=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I04 compound treatment 0.343 -0.0116 -0.59 0.346 -0.0168 -1.02 -1.1389 -0.9674 1910805 Bionet1_004402 Cc1ccc(cc1)S(=O)(=O)NNC(=O)C2CCN(Cc3ccccc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I05 compound treatment 0.348 -0.00663 -0.34 0.353 -0.00983 -0.59 -0.6593 -0.9646 1910806 Bionet1_004403 Cc1nnsc1SCCNS(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I06 compound treatment 0.342 -0.0126 -0.65 0.357 -0.00583 -0.35 -0.7055 -0.9594 1910807 Bionet1_004404 Clc1cccc(c1)C(=O)NNC(=O)C2CCN(Cc3ccccc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I07 compound treatment 0.365 0.0104 0.53 0.379 0.0162 0.98 1.0652 0.959 1910808 Bionet1_004405 Nn1c(SCc2ccc(Cl)cc2Cl)nnc1c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I08 compound treatment 0.357 0.00237 0.12 0.362 -8.33E-4 -0.05 0.0503 0.3826 1338374 Bionet1_004406 Clc1ccc(C(=O)c2c[nH]c(c2)C(=O)NCC3CCCO3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I09 compound treatment 0.337 -0.0176 -0.9 0.355 -0.00783 -0.47 -0.9716 -0.9547 1910809 Bionet1_004407 Cc1ccc(cc1)S(=O)(=O)NNC(=O)/C=C/c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I10 compound treatment 0.365 0.0104 0.53 0.378 0.0152 0.92 1.0225 0.9663 1734049 Bionet1_004408 Cc1ccc(cc1)C(=O)n2ccc(n2)c3ccccc3OCc4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I11 compound treatment 0.361 0.00637 0.33 0.359 -0.00383 -0.23 0.0669 0.1673 1910810 Bionet1_004409 Clc1ccc(/C=C/C(=O)NNC(=O)c2ccc(Cl)c(Cl)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I12 compound treatment 0.377 0.0224 1.14 0.367 0.00417 0.25 0.9869 0.8424 1196488 Bionet1_004410 Fc1ccc(COc2ccccc2c3ccn(n3)C(=O)c4ccc(F)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I13 compound treatment 0.34 -0.0146 -0.75 0.359 -0.00383 -0.23 -0.6924 -0.8845 1439273 Bionet1_004411 COc1ccc(Cc2nc(cs2)C(=O)Nc3ccc(OC)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I14 compound treatment 0.36 0.00537 0.27 0.367 0.00417 0.25 0.3722 0.999 1267271 Bionet1_004412 Fc1ccc(COc2ccccc2c3ccn(Cc4ccc(Cl)cc4)n3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I15 compound treatment 0.339 -0.0156 -0.8 0.338 -0.0248 -1.5 -1.625 -0.9566 1481246 Bionet1_004413 COc1ccc(NC(=O)c2csc(Cc3ccc(Cl)cc3)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I16 compound treatment 0.358 0.00337 0.17 0.347 -0.0158 -0.96 -0.5538 -0.5702 1700978 Bionet1_004414 COCc1cc(nc(n1)S(=O)(=O)Cc2ccc(Cl)cc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I17 compound treatment 0.349 -0.00563 -0.29 0.35 -0.0128 -0.77 -0.7512 -0.909 1614068 Bionet1_004415 COc1ccc(Cc2nc(cs2)C(=O)Nc3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I18 compound treatment 0.343 -0.0116 -0.59 0.362 -8.33E-4 -0.05 -0.4559 -0.7642 1565931 Bionet1_004416 OC1(CN2CCCC2)CCN(CC1)S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I19 compound treatment 0.385 0.0304 1.55 0.392 0.0292 1.76 2.3433 0.998 1667686 Bionet1_004417 COc1ccc(Cc2nc(cs2)C(=O)Nc3cc(Cl)cc(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I20 compound treatment 0.357 0.00237 0.12 0.356 -0.00683 -0.41 -0.2058 -0.4786 1329348 Bionet1_004418 OC1(CN2CCCCC2)CCN(CC1)S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I21 compound treatment 0.341 -0.0136 -0.7 0.352 -0.0108 -0.65 -0.9551 -0.9995 1910811 Bionet1_004419 COc1ccc(Cc2nc(cs2)C(=O)Nc3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I22 compound treatment 0.357 0.00237 0.12 0.361 -0.00183 -0.11 0.0076 0.0463 1224949 Bionet1_004420 CCN(CC)CC1(O)CCN(CC1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I23 positive control 0.091 -0.264 -13.48 0.089 -0.274 -16.53 -21.2207 -0.9949 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 I24 positive control 0.096 -0.259 -13.22 0.097 -0.266 -16.05 -20.6984 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J01 mock treatment 0.351 -0.00363 -0.19 0.366 0.00317 0.19 0.0041 0.0154 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J02 mock treatment 0.361 0.00637 0.33 0.364 0.00117 0.07 0.2803 0.8405 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J03 compound treatment 0.359 0.00437 0.22 0.364 0.00117 0.07 0.208 0.8868 1569213 Bionet1_004421 Fc1ccc(SCC(=O)N2CCC(CC2)c3nc4ccccc4s3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J04 compound treatment 0.369 0.0144 0.74 0.373 0.0102 0.61 0.9537 0.996 1910812 Bionet1_004422 COc1ccccc1CNC(=O)/C=C/c2cc3OCOc3cc2Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J05 compound treatment 0.375 0.0204 1.04 0.379 0.0162 0.98 1.4268 0.9995 1910813 Bionet1_004423 FC(F)(F)c1cccc(c1)C(=O)Nc2ccc3sc4ccccc4c(=O)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J06 compound treatment 0.387 0.0324 1.66 0.385 0.0222 1.34 2.1168 0.9944 1689211 Bionet1_004424 COc1ccc(CNC(=O)c2cc(c[nH]2)C(=O)c3ccc(cc3)C(C)(C)C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J07 compound treatment 0.383 0.0284 1.45 0.394 0.0312 1.88 2.3563 0.9918 1910814 Bionet1_004425 Clc1ccccc1C(=O)Nc2ccc3sc4ccccc4c(=O)c3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J08 compound treatment 0.345 -0.00963 -0.49 0.349 -0.0138 -0.84 -0.9385 -0.9682 1910815 Bionet1_004426 CS(=O)(=O)O/N=C/1\CCCCC1c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J09 compound treatment 0.364 0.00937 0.48 0.375 0.0122 0.73 0.8583 0.9786 1521833 Bionet1_004427 CC(=O)N(N1C(=O)C2C(C3c4ccccc4C2c5ccccc35)C1=O)C(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J10 compound treatment 0.338 -0.0166 -0.85 0.348 -0.0148 -0.9 -1.2343 -0.9997 1910816 Bionet1_004428 Fc1ccccc1CO/N=C/c2cc3OCOc3cc2Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J11 compound treatment 0.361 0.00637 0.33 0.36 -0.00283 -0.17 0.1095 0.2976 1208446 Bionet1_004429 Clc1ccc(cc1)S(=O)(=O)N2CCC(CC2)NC(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J12 compound treatment 0.352 -0.00263 -0.13 0.361 -0.00183 -0.11 -0.1732 -0.9954 1910817 Bionet1_004430 CN1C(=O)N(C)C(=O)C(=Cc2cc3OCOc3cc2Br)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J13 compound treatment 0.353 -0.00163 -0.08 0.36 -0.00283 -0.17 -0.1797 -0.945 1521290 Bionet1_004431 CC(C)NC(=O)NC1CCN(CC1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J14 compound treatment 0.379 0.0244 1.25 0.381 0.0182 1.1 1.6568 0.998 1910818 Bionet1_004432 COc1ccc(OC(=O)/C=C/c2cc3OCOc3cc2Br)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J15 compound treatment 0.36 0.00537 0.27 0.359 -0.00383 -0.23 0.0307 0.0855 1675076 Bionet1_004433 Clc1ccc(cc1)S(=O)(=O)N2CCC(CC2)NC(=O)N3CCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J16 compound treatment 0.361 0.00637 0.33 0.366 0.00317 0.19 0.3657 0.9677 1440868 Bionet1_004434 CN1CCN(CC1)c2ncc(CN3CCN(CC3)c4ccccc4)s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J17 compound treatment 0.361 0.00637 0.33 0.376 0.0132 0.79 0.7925 0.9225 1243115 Bionet1_004435 CC(C)OC(=O)NC1CCN(CC1)S(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J18 compound treatment 0.399 0.0444 2.27 0.417 0.0542 3.27 3.9166 0.9841 1737861 Bionet1_004436 Fc1cc(Br)ccc1NC(=S)Nc2ccc3nccnc3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J19 compound treatment 0.371 0.0164 0.84 0.377 0.0142 0.86 1.1968 0.9999 1416509 Bionet1_004437 Clc1ccc(cc1)S(=O)(=O)N2CCC(CC2)NC(=O)OCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J20 compound treatment 0.393 0.0384 1.96 0.402 0.0392 2.36 3.0594 0.9957 1910819 Bionet1_004438 O=C/1N(/C(=N/n2cnnc2)/S\C1=C/c3cccs3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J21 compound treatment 0.359 0.00437 0.22 0.361 -0.00183 -0.11 0.0799 0.3202 1910820 Bionet1_004439 COc1cc(nc(Oc2cc(Cl)c(Cl)cc2Cl)n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J22 compound treatment 0.358 0.00337 0.17 0.357 -0.00583 -0.35 -0.127 -0.3238 1375910 Bionet1_004440 CCC(=O)CC(C)(O)Nc1cc(n[nH]1)c2sccc2n3c(C)ccc3C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J23 positive control 0.09 -0.265 -13.53 0.09 -0.273 -16.47 -21.2142 -0.9952 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 J24 positive control 0.097 -0.258 -13.17 0.103 -0.26 -15.69 -20.4062 -0.9962 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K01 mock treatment 0.35 -0.00463 -0.24 0.362 -8.33E-4 -0.05 -0.2028 -0.8388 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K02 mock treatment 0.356 0.00137 0.07 0.362 -8.33E-4 -0.05 0.0141 0.1636 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K03 compound treatment 0.34 -0.0146 -0.75 0.353 -0.00983 -0.59 -0.9485 -0.9935 1459681 Bionet1_004441 COc1ccc(CNC(=O)c2csc(Cc3ccc(OC)cc3)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K04 compound treatment 0.352 -0.00263 -0.13 0.353 -0.00983 -0.59 -0.5147 -0.8456 1292538 Bionet1_004442 OC1(CN2CCCCCC2)CCN(CC1)S(=O)(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K05 compound treatment 0.37 0.0154 0.79 0.382 0.0192 1.16 1.3741 0.9823 1204526 Bionet1_004443 Clc1ccc(Cc2nc(cs2)C(=O)Nc3cc(Cl)cc(Cl)c3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K06 compound treatment 0.352 -0.00263 -0.13 0.339 -0.0238 -1.44 -1.1123 -0.7697 1910821 Bionet1_004444 Cc1ccc(cc1)S(=O)(=O)NNC(=O)/C=C/c2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K07 compound treatment 0.33 -0.0246 -1.26 0.343 -0.0198 -1.2 -1.737 -0.9997 1710874 Bionet1_004445 Clc1ccc(CNC(=O)c2csc(Cc3ccc(Cl)cc3)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K08 compound treatment 0.348 -0.00663 -0.34 0.35 -0.0128 -0.77 -0.7873 -0.9312 1232613 Bionet1_004446 Clc1ccc(Cn2nc-3c(CCc4ccccc43)cc2=O)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K09 compound treatment 0.339 -0.0156 -0.8 0.349 -0.0138 -0.84 -1.1554 -0.9998 1187522 Bionet1_004447 COc1ccc(CNC(=O)c2csc(Cc3ccc(Cl)cc3)n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K10 compound treatment 0.353 -0.00163 -0.08 0.36 -0.00283 -0.17 -0.1797 -0.945 1222253 Bionet1_004448 Clc1ccc(Cn2nc-3c(CCc4ccccc43)cc2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K11 compound treatment 0.337 -0.0176 -0.9 0.359 -0.00383 -0.23 -0.8009 -0.8608 1333888 Bionet1_004449 COc1ccccc1CNC(=O)c2csc(Cc3ccc(Cl)cc3)n2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K12 compound treatment 0.398 0.0434 2.22 0.406 0.0432 2.61 3.4109 0.9968 1910822 Bionet1_004450 CCSC/1=Nc2ccccc2\C1=N\Nc3c(Cl)cc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K13 compound treatment 0.336 -0.0186 -0.95 0.347 -0.0158 -0.96 -1.3493 -1.0 1633414 Bionet1_004451 COc1ccc(Cc2nc(cs2)C(=O)NCc3ccccc3OC)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K14 compound treatment 0.395 0.0404 2.06 0.412 0.0492 2.97 3.5586 0.9843 1910823 Bionet1_004452 CCCSC/1=Nc2ccccc2\C1=N\Nc3c(Cl)cc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K15 compound treatment 0.362 0.00737 0.38 0.37 0.00717 0.43 0.5726 0.9977 1910824 Bionet1_004453 COc1ccc(NC(=O)Cc2nc(no2)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K16 compound treatment 0.397 0.0424 2.17 0.413 0.0502 3.03 3.6736 0.9865 1910825 Bionet1_004454 CC(C)SC/1=Nc2ccccc2\C1=N\Nc3c(Cl)cc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K17 compound treatment 0.357 0.00237 0.12 0.369 0.00617 0.37 0.3491 0.8915 1243839 Bionet1_004455 O=C(C1CCN(CC1)S(=O)(=O)c2ccccc2)N3CCC4(CC3)OCCO4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K18 compound treatment 0.359 0.00437 0.22 0.365 0.00217 0.13 0.2507 0.9673 1910826 Bionet1_004456 CCOc1ccc(NC(=O)Cn2c(nc3ccccc23)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K19 compound treatment 0.36 0.00537 0.27 0.364 0.00117 0.07 0.2441 0.8605 1644095 Bionet1_004457 O=C(C1CCN(CC1)S(=O)(=O)c2ccccc2)N3CCCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K20 compound treatment 0.36 0.00537 0.27 0.357 -0.00583 -0.35 -0.0547 -0.1224 1910827 Bionet1_004458 CCOc1ccccc1NC(=O)Cn2c(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K21 compound treatment 0.361 0.00637 0.33 0.365 0.00217 0.13 0.323 0.9196 1660753 Bionet1_004459 CC1CN(CC(C)O1)C(=O)C2CCN(CC2)S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K22 compound treatment 0.361 0.00637 0.33 0.36 -0.00283 -0.17 0.1095 0.2976 1910828 Bionet1_004460 FC(F)(F)c1nc2ccccc2n1CC(=O)Nc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K23 positive control 0.099 -0.256 -13.07 0.09 -0.273 -16.47 -20.8888 -0.9934 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 K24 positive control 0.097 -0.258 -13.17 0.119 -0.244 -14.72 -19.7232 -0.9985 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L01 mock treatment 0.352 -0.00263 -0.13 0.372 0.00917 0.55 0.2964 0.5205 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L02 mock treatment 0.355 3.75E-4 0.02 0.367 0.00417 0.25 0.1914 0.7588 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L03 compound treatment 0.355 3.75E-4 0.02 0.355 -0.00783 -0.47 -0.3208 -0.6779 1210262 Bionet1_004461 Cc1ccc(cc1)S(=O)(=O)N2CCC(CC2)NC(=O)N3CCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L04 compound treatment 0.368 0.0134 0.68 0.37 0.00717 0.43 0.7895 0.9756 1910829 Bionet1_004462 Clc1ccc(/C=C/2\S/C(=N\n3cnnc3)/N(C2=O)c4ccccc4)cn1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L05 compound treatment 0.342 -0.0126 -0.65 0.368 0.00517 0.31 -0.2359 -0.3291 1623157 Bionet1_004463 COc1ccc(cc1)S(=O)(=O)N2CCC(CC2)NC(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L06 compound treatment 0.367 0.0124 0.63 0.375 0.0122 0.73 0.9668 0.9972 1910830 Bionet1_004464 Cc1ccc(C)n1c2ccsc2c3cc4ncc(C#N)c(n4n3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L07 compound treatment 0.352 -0.00263 -0.13 0.357 -0.00583 -0.35 -0.3439 -0.9126 1220611 Bionet1_004465 COc1ccc(cc1)S(=O)(=O)N2CCC(CC2)NC(=O)NC(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L08 compound treatment 0.367 0.0124 0.63 0.38 0.0172 1.04 1.1802 0.972 1910831 Bionet1_004466 CCN/1C(=O)/C(=C/c2ccc(NC(=O)C)cc2)/S\C1=N/n3cnnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L09 compound treatment 0.371 0.0164 0.84 0.377 0.0142 0.86 1.1968 0.9999 1910832 Bionet1_004467 CCOC(=O)c1cnc(SC)nc1Oc2cc(Cl)ccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L10 compound treatment 0.351 -0.00363 -0.19 0.354 -0.00883 -0.53 -0.5081 -0.9001 1910833 Bionet1_004468 COc1ccc(cc1)S(=O)(=O)NNC(=O)C2CC(=NO2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L11 compound treatment 0.362 0.00737 0.38 0.36 -0.00283 -0.17 0.1457 0.3519 1910834 Bionet1_004469 COc1cc(nc(Oc2ccc(Cl)c3cccnc23)n1)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L12 compound treatment 0.36 0.00537 0.27 0.367 0.00417 0.25 0.3722 0.999 1910835 Bionet1_004470 O=C(NC1(CC2CC3CC(C2)C1)C3)/C(=C/c4cccs4)/c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L13 compound treatment 0.357 0.00237 0.12 0.358 -0.00483 -0.29 -0.1204 -0.3811 1910836 Bionet1_004471 CCOC(=O)c1cnc(SC)nc1Oc2cc(Cl)c(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L14 compound treatment 0.359 0.00437 0.22 0.362 -8.33E-4 -0.05 0.1226 0.5347 1910837 Bionet1_004472 Cc1onc(c1C(=O)N2CCN=C(C=C2)C(F)(F)F)c3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L15 compound treatment 0.352 -0.00263 -0.13 0.359 -0.00383 -0.23 -0.2585 -0.9664 1910838 Bionet1_004473 CCOC(=O)c1cnc(SC)nc1Oc2ccc(Cl)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L16 compound treatment 0.365 0.0104 0.53 0.367 0.00417 0.25 0.553 0.9419 1910839 Bionet1_004474 O=C(NCCCN1CCOCC1)/C(=C/c2cccs2)/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L17 compound treatment 0.376 0.0214 1.09 0.375 0.0122 0.73 1.2922 0.9813 1910840 Bionet1_004475 CSc1nc2ccccc2cc1/C=N/OC(=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L18 compound treatment 0.355 3.75E-4 0.02 0.368 0.00517 0.31 0.2341 0.7492 1910841 Bionet1_004476 Fc1cccc(CN2CCC(CC2)C(=O)NNC(=O)c3cccs3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L19 compound treatment 0.361 0.00637 0.33 0.37 0.00717 0.43 0.5364 0.9903 1910842 Bionet1_004477 Cc1cc(C)c2c(c(NC(=O)OCc3ccccc3)sc2n1)n4cccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L20 compound treatment 0.358 0.00337 0.17 0.366 0.00317 0.19 0.2572 0.9987 1910843 Bionet1_004478 COc1cccc(c1)C(=O)c2c[nH]c(c2)C(=O)NCCCN3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L21 compound treatment 0.365 0.0104 0.53 0.363 1.67E-4 0.01 0.3822 0.7204 1328320 Bionet1_004479 COc1ccc(NC(=O)C(NC(=O)C)C(=O)NCc2ccccc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L22 compound treatment 0.361 0.00637 0.33 0.366 0.00317 0.19 0.3657 0.9677 1910844 Bionet1_004480 Cc1ccc(C)n1c2sccc2c3cc4nccc(c5ccc(F)cc5)n4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L23 positive control 0.093 -0.262 -13.38 0.094 -0.269 -16.23 -20.935 -0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 L24 positive control 0.099 -0.256 -13.07 0.103 -0.26 -15.69 -20.3339 -0.9959 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M01 mock treatment 0.357 0.00237 0.12 0.366 0.00317 0.19 0.221 0.976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M02 mock treatment 0.357 0.00237 0.12 0.364 0.00117 0.07 0.1357 0.9664 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M03 compound treatment 0.356 0.00137 0.07 0.357 -0.00583 -0.35 -0.1993 -0.555 1716501 Bionet1_004481 Clc1ccc(NC(=O)C2CCN(CC2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M04 compound treatment 0.367 0.0124 0.63 0.364 0.00117 0.07 0.4972 0.781 1910845 Bionet1_004482 FC(F)(F)c1nc2ccccc2n1CC(=O)Nc3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M05 compound treatment 0.338 -0.0166 -0.85 0.368 0.00517 0.31 -0.3805 -0.4203 1594406 Bionet1_004483 COc1ccc(NC(=O)C2CCN(CC2)S(=O)(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M06 compound treatment 0.356 0.00137 0.07 0.366 0.00317 0.19 0.1849 0.9077 1910846 Bionet1_004484 FC(F)(F)c1nc2ccccc2n1CC(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M07 compound treatment 0.357 0.00237 0.12 0.363 1.67E-4 0.01 0.093 0.7631 1428687 Bionet1_004485 O=C(C1CCN(CC1)S(=O)(=O)c2ccccc2)C3C(=O)CCCC3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M08 compound treatment 0.354 -6.25E-4 -0.03 0.36 -0.00283 -0.17 -0.1435 -0.8249 1910847 Bionet1_004486 FC(F)(F)c1nc2ccccc2n1CC(=O)Nc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M09 compound treatment 0.36 0.00537 0.27 0.363 1.67E-4 0.01 0.2015 0.7325 1316439 Bionet1_004487 CC1(C)CC(=O)C(C(=O)C2CCN(CC2)S(=O)(=O)c3ccccc3)C(=O)C1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M10 compound treatment 0.355 3.75E-4 0.02 0.363 1.67E-4 0.01 0.0207 0.9547 1910848 Bionet1_004488 FC(F)(F)c1nc2ccccc2n1CC(=O)Nc3ccccc3C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M11 compound treatment 0.356 0.00137 0.07 0.362 -8.33E-4 -0.05 0.0141 0.1636 1910849 Bionet1_004489 Clc1ccc(NC(=O)c2cnn(c2c3ccccc3)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M12 compound treatment 0.352 -0.00263 -0.13 0.361 -0.00183 -0.11 -0.1732 -0.9954 1910850 Bionet1_004490 Cc1nc(sc1C(=O)CSc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M13 compound treatment 0.347 -0.00763 -0.39 0.357 -0.00583 -0.35 -0.5247 -0.9987 1225671 Bionet1_004491 Cc1cccc(NC(=O)c2cnn(c2c3ccccc3)c4ccccc4)c1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M14 compound treatment 0.377 0.0224 1.14 0.38 0.0172 1.04 1.5418 0.9988 1910851 Bionet1_004492 Cc1nc(sc1C(=O)CSc2ccc(Cl)cc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M15 compound treatment 0.374 0.0194 0.99 0.38 0.0172 1.04 1.4333 0.9997 1174308 Bionet1_004493 Cc1nc2cc(C)ccn2c1C(=O)CSc3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M16 compound treatment 0.368 0.0134 0.68 0.374 0.0112 0.67 0.9603 1.0 1910852 Bionet1_004494 Cc1nc(sc1C(=O)CSc2cccc(Cl)c2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M17 compound treatment 0.368 0.0134 0.68 0.371 0.00817 0.49 0.8322 0.9871 1641329 Bionet1_004495 Cc1nc2cc(C)ccn2c1C(=O)CSc3cccc(Cl)c3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M18 compound treatment 0.378 0.0234 1.2 0.38 0.0172 1.04 1.5779 0.9975 1910853 Bionet1_004496 COC(=O)c1ccccc1SCC(=O)c2sc(nc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M19 compound treatment 0.344 -0.0106 -0.54 0.368 0.00517 0.31 -0.1636 -0.2612 1325357 Bionet1_004497 Cc1nc2cc(C)ccn2c1C(=O)CSc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M20 compound treatment 0.349 -0.00563 -0.29 0.361 -0.00183 -0.11 -0.2816 -0.9139 1910854 Bionet1_004498 COc1cccc(SCC(=O)c2sc(nc2C)c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M21 compound treatment 0.381 0.0264 1.35 0.376 0.0132 0.79 1.5157 0.9682 1910855 Bionet1_004499 Cc1nc2cc(C)ccn2c1C(=O)CSc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M22 compound treatment 0.353 -0.00163 -0.08 0.358 -0.00483 -0.29 -0.2651 -0.8737 1910856 Bionet1_004500 Cc1nc(sc1C(=O)CS(=O)(=O)c2ccccc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M23 positive control 0.092 -0.263 -13.43 0.091 -0.272 -16.41 -21.0992 -0.995 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 M24 positive control 0.1 -0.255 -13.02 0.098 -0.265 -15.99 -20.5111 -0.9948 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N01 mock treatment 0.363 0.00837 0.43 0.366 0.00317 0.19 0.438 0.9339 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N02 mock treatment 0.354 -6.25E-4 -0.03 0.37 0.00717 0.43 0.2833 0.6531 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N03 compound treatment 0.358 0.00337 0.17 0.371 0.00817 0.49 0.4706 0.901 1910857 Bionet1_004501 FC(F)(F)c1nnc(nc1Oc2ccc(Cl)cc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N04 compound treatment 0.402 0.0474 2.42 0.398 0.0352 2.12 3.214 0.9978 1910858 Bionet1_004502 COc1ccc(/C=C/2\S/C(=N\n3cnnc3)/N(C2=O)c4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N05 compound treatment 0.362 0.00737 0.38 0.365 0.00217 0.13 0.3591 0.8998 1910859 Bionet1_004503 CN(NC(=O)c1ccc(C)cc1)c2nc(nnc2C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N06 compound treatment 0.361 0.00637 0.33 0.367 0.00417 0.25 0.4084 0.9918 1910860 Bionet1_004504 Fc1cccc(CN2CCC(CC2)C(=O)NNC(=O)c3cccc(Cl)c3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N07 compound treatment 0.369 0.0144 0.74 0.37 0.00717 0.43 0.8257 0.9681 1910861 Bionet1_004505 COC(=O)c1ccccc1OC(=O)Cn2c(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N08 compound treatment 0.361 0.00637 0.33 0.359 -0.00383 -0.23 0.0669 0.1673 1910862 Bionet1_004506 COc1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCCCN3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N09 compound treatment 0.358 0.00337 0.17 0.359 -0.00383 -0.23 -0.0416 -0.1441 1263862 Bionet1_004507 COc1ccc(CNC(=O)C(NC(=O)C)C(=O)Nc2ccc(OC)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N10 compound treatment 0.373 0.0184 0.94 0.374 0.0112 0.67 1.141 0.9867 1370698 Bionet1_004508 COc1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N11 compound treatment 0.358 0.00337 0.17 0.359 -0.00383 -0.23 -0.0416 -0.1441 1173583 Bionet1_004509 COc1ccc(NC(=O)C(NC(=O)C)C(=O)NCc2ccccc2Cl)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N12 compound treatment 0.418 0.0634 3.24 0.395 0.0322 1.94 3.6645 0.97 1910863 Bionet1_004510 Cc1nc(sc1C(=O)/C=C/c2ccc(Oc3ccccc3)cc2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N13 compound treatment 0.364 0.00937 0.48 0.363 1.67E-4 0.01 0.3461 0.7218 1151772 Bionet1_004511 COc1ccc(NC(=O)C(NC(=O)C)C(=O)NCc2ccccc2OC)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N14 compound treatment 0.391 0.0364 1.86 0.386 0.0232 1.4 2.3041 0.9901 1910864 Bionet1_004512 Cc1nc(sc1C(=O)/C=C/c2c(F)cccc2Cl)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N15 compound treatment 0.364 0.00937 0.48 0.357 -0.00583 -0.35 0.09 0.1512 1476122 Bionet1_004513 COc1ccc(NC(=O)C(NC(=O)C)C(=O)NCc2ccc(F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N16 compound treatment 0.389 0.0344 1.76 0.383 0.0202 1.22 2.1037 0.9839 1910865 Bionet1_004514 COc1ccc(/C=C/C(=O)c2sc(nc2C)c3ccccc3)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N17 compound treatment 0.355 3.75E-4 0.02 0.357 -0.00583 -0.35 -0.2354 -0.6676 1910866 Bionet1_004515 CC(=O)Nc1ccc(OC(=O)Cn2c(nc3ccccc23)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N18 compound treatment 0.364 0.00937 0.48 0.36 -0.00283 -0.17 0.218 0.4284 1910867 Bionet1_004516 CCCNC(=O)C(=O)c1cccn1c2c(cnn2c3ccccc3)C(=O)OCC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N19 compound treatment 0.362 0.00737 0.38 0.356 -0.00683 -0.41 -0.025 -0.0448 1910868 Bionet1_004517 CC(C)(C)c1ccc(OC(=O)Cn2c(nc3ccccc23)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N20 compound treatment 0.356 0.00137 0.07 0.357 -0.00583 -0.35 -0.1993 -0.555 1910869 Bionet1_004518 COC(=O)c1sccc1n2cccc2C(=O)C(=O)Nc3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N21 compound treatment 0.368 0.0134 0.68 0.376 0.0132 0.79 1.0456 0.9972 1910870 Bionet1_004519 CC(C)CC(=O)NN(C)c1nc(nnc1C(F)(F)F)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N22 compound treatment 0.366 0.0114 0.58 0.364 0.00117 0.07 0.4611 0.787 1910871 Bionet1_004520 COc1ccc(NC(=O)c2ccc(CNC(=O)OCC(F)(F)F)cc2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N23 positive control 0.094 -0.261 -13.33 0.091 -0.272 -16.41 -21.0269 -0.9947 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 N24 positive control 0.102 -0.253 -12.92 0.098 -0.265 -15.99 -20.4388 -0.9944 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O01 mock treatment 0.367 0.0124 0.63 0.372 0.00917 0.55 0.8387 0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O02 mock treatment 0.367 0.0124 0.63 0.367 0.00417 0.25 0.6253 0.9183 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O03 compound treatment 0.357 0.00237 0.12 0.36 -0.00283 -0.17 -0.0351 -0.1672 1910872 Bionet1_004521 Cc1ccc(NC(=O)Cc2nc(no2)c3cccc(c3)C(F)(F)F)c(C)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O04 compound treatment 0.372 0.0174 0.89 0.372 0.00917 0.55 1.0195 0.974 1591230 Bionet1_004522 Cc1nc(sc1C(=O)CSc2nc3ccccc3o2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O05 compound treatment 0.355 3.75E-4 0.02 0.353 -0.00983 -0.59 -0.4062 -0.6839 1257867 Bionet1_004523 Clc1ccc(NC(=O)c2csc(Cc3ccccc3)n2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O06 compound treatment 0.366 0.0114 0.58 0.37 0.00717 0.43 0.7172 0.9894 1910873 Bionet1_004524 Clc1ccc(CSc2nnc(/C=C/c3ccccc3)o2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O07 compound treatment 0.385 0.0304 1.55 0.373 0.0102 0.61 1.5322 0.9175 1291488 Bionet1_004525 Clc1ccc(NC(=O)c2csc(Cc3ccccc3)n2)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O08 compound treatment 0.377 0.0224 1.14 0.384 0.0212 1.28 1.7125 0.9985 1910874 Bionet1_004526 Clc1ccc(CSc2nnc(/C=C/c3ccccc3)o2)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O09 compound treatment 0.37 0.0154 0.79 0.367 0.00417 0.25 0.7338 0.889 1185400 Bionet1_004527 Clc1cc(Cl)cc(NC(=O)c2csc(Cc3ccccc3)n2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O10 compound treatment 0.372 0.0174 0.89 0.37 0.00717 0.43 0.9341 0.9453 1910875 Bionet1_004528 Clc1ccc(CSc2cc3CCc4ccccc4-c3nn2)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O11 compound treatment 0.373 0.0184 0.94 0.371 0.00817 0.49 1.013 0.9547 1733781 Bionet1_004529 COc1ccc(NC(=O)C2CCN(CC2)S(=O)(=O)c3ccc(C)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O12 compound treatment 0.396 0.0414 2.12 0.395 0.0322 1.94 2.8691 0.9991 1910876 Bionet1_004530 Clc1ccc(CSc2cc3CCc4ccccc4-c3nn2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O13 compound treatment 0.382 0.0274 1.4 0.375 0.0122 0.73 1.5091 0.9547 1460748 Bionet1_004531 Cc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)Nc3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O14 compound treatment 0.365 0.0104 0.53 0.359 -0.00383 -0.23 0.2115 0.3654 1910877 Bionet1_004532 Brc1ccc(cc1)S(=O)(=O)O/N=C\2/CCCc3occc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O15 compound treatment 0.369 0.0144 0.74 0.373 0.0102 0.61 0.9537 0.996 1701733 Bionet1_004533 Cc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)C3C(=O)CCCC3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O16 compound treatment 0.373 0.0184 0.94 0.369 0.00617 0.37 0.9276 0.9179 1910878 Bionet1_004534 FC(F)(F)c1nc2ccccc2n1CC(=O)NCc3ccccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O17 compound treatment 0.373 0.0184 0.94 0.373 0.0102 0.61 1.0984 0.9787 1647370 Bionet1_004535 Cc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)NC3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O18 compound treatment 0.367 0.0124 0.63 0.372 0.00917 0.55 0.8387 0.9978 1910879 Bionet1_004536 COc1ccc(CNC(=O)Cn2c(nc3ccccc23)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O19 compound treatment 0.368 0.0134 0.68 0.36 -0.00283 -0.17 0.3626 0.5144 1235812 Bionet1_004537 Cc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O20 compound treatment 0.356 0.00137 0.07 0.365 0.00217 0.13 0.1422 0.9576 1910880 Bionet1_004538 FC(F)(F)c1nc2ccccc2n1CC(=O)N3CCN(CC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O21 compound treatment 0.359 0.00437 0.22 0.368 0.00517 0.31 0.3787 0.9867 1910881 Bionet1_004539 Fc1ccc(Sc2nc(nnc2C(F)(F)F)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O22 compound treatment 0.368 0.0134 0.68 0.373 0.0102 0.61 0.9176 0.9985 1910882 Bionet1_004540 Cc1ccc(C)n1c2ccsc2c3cc4nc(C)cc(n4n3)C(F)(F)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O23 positive control 0.094 -0.261 -13.33 0.09 -0.273 -16.47 -21.0696 -0.9945 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 O24 positive control 0.1 -0.255 -13.02 0.097 -0.266 -16.05 -20.5538 -0.9946 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P01 mock treatment 0.38 0.0254 1.3 0.37 0.00717 0.43 1.2234 0.8945 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P02 mock treatment 0.376 0.0214 1.09 0.372 0.00917 0.55 1.1641 0.9503 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P03 compound treatment 0.371 0.0164 0.84 0.367 0.00417 0.25 0.7699 0.8807 1910883 Bionet1_004541 CN(NC(=O)C(C)(C)C)c1nc(nnc1C(F)(F)F)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P04 compound treatment 0.376 0.0214 1.09 0.4 0.0372 2.24 2.3594 0.9454 1910884 Bionet1_004542 C/C(=N\OC(=O)Nc1cccc(Cl)c1)/c2sc(nc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P05 compound treatment 0.348 -0.00663 -0.34 0.366 0.00317 0.19 -0.1044 -0.2683 1910885 Bionet1_004543 FC(F)(F)c1nc2ccccc2n1CC(=O)Oc3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P06 compound treatment 0.367 0.0124 0.63 0.376 0.0132 0.79 1.0095 0.9936 1910886 Bionet1_004544 C/C(=N\OC(=O)c1ccc(F)cc1)/c2sc(nc2C)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P07 compound treatment 0.363 0.00837 0.43 0.369 0.00617 0.37 0.566 0.9976 1910887 Bionet1_004545 FC(F)(F)c1nc2ccccc2n1CC(=O)Oc3cc(Cl)ccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P08 compound treatment 0.361 0.00637 0.33 0.365 0.00217 0.13 0.323 0.9196 1516902 Bionet1_004546 Clc1ccc(Cn2cc(ccc2=O)c3nc(no3)c4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P09 compound treatment 0.375 0.0204 1.04 0.389 0.0262 1.58 1.8537 0.9796 1910888 Bionet1_004547 CCCCC(=O)NN(C)c1nc(nnc1C(F)(F)F)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P10 compound treatment 0.371 0.0164 0.84 0.365 0.00217 0.13 0.6845 0.8078 1656008 Bionet1_004548 Clc1ccc(Cn2cc(ccc2=O)c3nc(no3)c4ccncc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P11 compound treatment 0.343 -0.0116 -0.59 0.356 -0.00683 -0.41 -0.712 -0.9841 1910889 Bionet1_004549 FC(F)(F)c1nc2ccccc2n1CC(=O)Oc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P12 compound treatment 0.361 0.00637 0.33 0.368 0.00517 0.31 0.451 0.9998 1910890 Bionet1_004550 COC(=O)c1sc2ccccc2c1n3cccc3C(=O)C(=O)NCC=C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P13 compound treatment 0.364 0.00937 0.48 0.371 0.00817 0.49 0.6876 0.9999 1529643 Bionet1_004551 COc1ccc(cc1)c2ccnc(n2)c3ccc(OC(=O)c4ccc(F)cc4)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P14 compound treatment 0.362 0.00737 0.38 0.374 0.0112 0.67 0.7433 0.9623 1910891 Bionet1_004552 COC(=O)c1sc2ccccc2c1n3cccc3C(=O)C(=O)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P15 compound treatment 0.362 0.00737 0.38 0.36 -0.00283 -0.17 0.1457 0.3519 1910892 Bionet1_004553 Fc1cccc(Cl)c1/C=C\2/C(OC(=O)Nc3ccccc3)C4CCN2CC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P16 compound treatment 0.369 0.0144 0.74 0.374 0.0112 0.67 0.9964 0.9991 1245946 Bionet1_004554 Fc1ccc(cc1)N2CCN(CC2)c3cc(=O)[nH]nc3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P17 compound treatment 0.375 0.0204 1.04 0.381 0.0182 1.1 1.5122 0.9997 1098329 Bionet1_004555 COc1ccc(cc1)C2C(=C(N)Oc3c2c(C)nn3c4ccccc4)C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P18 compound treatment 0.375 0.0204 1.04 0.368 0.00517 0.31 0.9572 0.8802 1538132 Bionet1_004556 Clc1ccc(cc1)C(=O)N2CCN(CC2)c3cc(=O)[nH]nc3c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P19 compound treatment 0.382 0.0274 1.4 0.58 0.217 13.11 10.2599 0.7782 1910893 Bionet1_004557 Fc1cccc(Cl)c1COc2ccc(/C=C\3/SC(=O)NC3=O)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P20 compound treatment 0.363 0.00837 0.43 0.365 0.00217 0.13 0.3953 0.8828 1910894 Bionet1_004558 Cc1ccc(CSc2nc(Cl)c3sc4nc(C)cc(C)c4c3n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P21 compound treatment 0.364 0.00937 0.48 0.373 0.0102 0.61 0.7729 0.9925 1910895 Bionet1_004559 CN1C(=O)N(C)C(=O)C(=Cc2ccc(OCc3cccc(Cl)c3)cc2)C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P22 compound treatment 0.352 -0.00263 -0.13 0.363 1.67E-4 0.01 -0.0878 -0.6523 1486405 Bionet1_004560 COC(=O)C1CSC(N1C(=O)c2ccccc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P23 positive control 0.098 -0.257 -13.12 0.091 -0.272 -16.41 -20.8823 -0.9939 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.581 P24 positive control 0.105 -0.25 -12.76 0.133 -0.23 -13.87 -18.8363 -0.9991 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A01 mock treatment 0.334 -0.0338 -1.73 0.333 -0.0286 -1.73 -2.4414 -1.0 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A02 mock treatment 0.329 -0.0388 -1.98 0.337 -0.0246 -1.48 -2.4515 -0.9899 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A03 compound treatment 0.333 -0.0348 -1.78 0.337 -0.0246 -1.48 -2.3069 -0.996 1326034 Bionet1_004561 COC(=O)C1CSC(N1C(=O)c2ccc(OC)cc2)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A04 compound treatment 0.335 -0.0328 -1.68 0.336 -0.0256 -1.55 -2.2772 -0.9992 1231839 Bionet1_004562 Cc1ccccc1Cn2nc(c3ccccc3)c(cc2=O)N4CCCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A05 compound treatment 0.34 -0.0278 -1.42 0.336 -0.0256 -1.55 -2.0964 -0.9991 1167778 Bionet1_004563 Cc1cc(C)c2c(n1)sc3c(nc(SCC=C)nc32)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A06 compound treatment 0.326 -0.0418 -2.14 0.343 -0.0186 -1.12 -2.3038 -0.9549 1594179 Bionet1_004564 O=C(ON1C(=O)C2C(C3c4ccccc4C2c5ccccc35)C1=O)C6CC6 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A07 compound treatment 0.337 -0.0308 -1.57 0.351 -0.0106 -0.64 -1.5646 -0.9213 1910896 Bionet1_004565 Cc1ccc(cc1)S(=O)(=O)CC(=O)Nc2ccc(cc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A08 compound treatment 0.351 -0.0168 -0.86 0.358 -0.00359 -0.22 -0.7596 -0.859 1910897 Bionet1_004566 Cc1ccc(cc1)C(=O)NNC(=O)C(=O)c2c([nH]c3ccccc23)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A09 compound treatment 0.329 -0.0388 -1.98 0.334 -0.0276 -1.67 -2.5795 -0.9963 1910898 Bionet1_004567 O=C(CS(=O)(=O)c1ccccc1)Nc2ccc(cc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A10 compound treatment 0.326 -0.0418 -2.14 0.328 -0.0336 -2.03 -2.9441 -0.9997 1910899 Bionet1_004568 Fc1ccc(CON2C(=O)C3C(C4c5ccccc5C3c6ccccc46)C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A11 compound treatment 0.342 -0.0258 -1.32 0.339 -0.0226 -1.36 -1.8961 -0.9999 1910900 Bionet1_004569 COC(=O)c1ccccc1SCC(=O)Nc2ccc(cc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A12 compound treatment 0.328 -0.0398 -2.03 0.348 -0.0136 -0.82 -2.0181 -0.9204 1514147 Bionet1_004570 C(Sc1nc(N2CCCC2)c3sc4ccccc4c3n1)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A13 compound treatment 0.328 -0.0398 -2.03 0.34 -0.0216 -1.3 -2.3596 -0.9769 1675788 Bionet1_004571 Clc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A14 compound treatment 0.361 -0.00677 -0.35 0.372 0.0104 0.63 0.1996 0.2782 1197433 Bionet1_004572 Cc1ccc(CSc2nc(NCC=C)c3sc4ccccc4c3n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A15 compound treatment 0.332 -0.0358 -1.83 0.342 -0.0196 -1.18 -2.1296 -0.9778 1910901 Bionet1_004573 CSc1nc2ccccc2cc1/C=C(\C#N)/c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A16 compound treatment 0.357 -0.0108 -0.55 0.365 0.00341 0.21 -0.2439 -0.415 1506850 Bionet1_004574 Cc1ccc(CSc2nc(NC3CC3)c4sc5ccccc5c4n2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A17 compound treatment 0.33 -0.0378 -1.93 0.339 -0.0226 -1.36 -2.3299 -0.9855 1910902 Bionet1_004575 CSc1nc2ccccc2cc1/C=C(\C#N)/c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A18 compound treatment 0.335 -0.0328 -1.68 0.337 -0.0246 -1.48 -2.2345 -0.9982 1910903 Bionet1_004576 COC(=O)c1ccccc1Sc2nc(SC)nc3c4ccccc4sc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A19 compound treatment 0.327 -0.0408 -2.08 0.335 -0.0266 -1.61 -2.6092 -0.9917 1910904 Bionet1_004577 CSc1nc2ccccc2cc1/C=C(\C#N)/c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A20 compound treatment 0.333 -0.0348 -1.78 0.272 -0.0896 -5.41 -5.0815 -0.8925 1910905 Bionet1_004578 CSc1nc(Sc2ccc(F)cc2)c3sc4ccccc4c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A21 compound treatment 0.325 -0.0428 -2.19 0.329 -0.0326 -1.97 -2.9376 -0.9986 1910906 Bionet1_004579 COc1ccc(cc1OC)/C(=C/c2cc3ccccc3nc2SC)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A22 compound treatment 0.332 -0.0358 -1.83 0.339 -0.0226 -1.36 -2.2576 -0.9896 1910907 Bionet1_004580 CSc1nc(Oc2ccc3ccccc3c2)c4sc5ccccc5c4n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A23 positive control 0.087 -0.281 -14.36 0.087 -0.275 -16.58 -21.873 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 A24 positive control 0.088 -0.28 -14.31 0.093 -0.269 -16.21 -21.5807 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B01 mock treatment 0.361 -0.00677 -0.35 0.352 -0.00959 -0.58 -0.6542 -0.9697 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B02 mock treatment 0.369 0.00123 0.06 0.357 -0.00459 -0.28 -0.1515 -0.5327 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B03 compound treatment 0.362 -0.00577 -0.29 0.357 -0.00459 -0.28 -0.4046 -0.9995 1910908 Bionet1_004581 CCCc1c(C)nc2cc(nn2c1C)c3sccc3n4c(C)ccc4C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B04 compound treatment 0.363 -0.00477 -0.24 0.361 -5.94E-4 -0.04 -0.1977 -0.8025 1237533 Bionet1_004582 Cc1cccc(c1)c2nc(SCc3cccc(F)c3)c(C#N)c4CCCCc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B05 compound treatment 0.363 -0.00477 -0.24 0.369 0.00741 0.45 0.1438 0.2824 1910909 Bionet1_004583 COCc1cc(O)n2nc(cc2n1)c3sccc3n4c(C)ccc4C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B06 compound treatment 0.358 -0.00977 -0.5 0.364 0.00241 0.15 -0.2504 -0.4815 1699363 Bionet1_004584 COC(=O)CSc1nc(c2cccc(C)c2)c3CCCCc3c1C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B07 compound treatment 0.399 0.0312 1.6 0.397 0.0354 2.14 2.6407 0.9897 1910910 Bionet1_004585 COCCNC(=O)C1CCC(=O)N(C2CCCCC2)C1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B08 compound treatment 0.353 -0.0148 -0.76 0.355 -0.00659 -0.4 -0.8154 -0.9553 1910911 Bionet1_004586 COC(=O)C1CCN(CC1)C(=O)CC(NC(=O)C(F)(F)F)c2cccs2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B09 compound treatment 0.373 0.00523 0.27 0.384 0.0224 1.35 1.1457 0.8309 1311118 Bionet1_004587 CCOC(=O)NC(C1COc2ccccc2C1=O)c3cccc(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B10 compound treatment 0.368 2.33E-4 0.01 0.37 0.00841 0.51 0.3673 0.7235 1143750 Bionet1_004588 Cc1nc2c(cnn2c(N)c1c3ccc(F)cc3)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B11 compound treatment 0.368 2.33E-4 0.01 0.354 -0.00759 -0.46 -0.3157 -0.6885 1910912 Bionet1_004589 Cc1ccc(C)n1c2ccsc2c3cc4nccc(c5ccc(F)cc5)n4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B12 compound treatment 0.368 2.33E-4 0.01 0.356 -0.00559 -0.34 -0.2303 -0.6817 1304964 Bionet1_004590 COc1ccc(cc1)c2cnn(c2N)c3nc(cs3)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B13 compound treatment 0.354 -0.0138 -0.7 0.37 0.00841 0.51 -0.1389 -0.1601 1910913 Bionet1_004591 COc1cc2NC(=S)N3C(CC4CCCCC4)C(=O)N=C3c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B14 compound treatment 0.36 -0.00777 -0.4 0.359 -0.00259 -0.16 -0.3915 -0.9172 1910914 Bionet1_004592 COC(=O)C(/C=N/Nc1ncc(cc1Cl)C(F)(F)F)n2cncn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B15 compound treatment 0.368 2.33E-4 0.01 0.367 0.00541 0.33 0.2392 0.7325 1193808 Bionet1_004593 Fc1ccccc1N2CCN(CC2)C(=O)C3Cc4c(O3)ccc5ccccc45 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B16 compound treatment 0.37 0.00223 0.11 0.368 0.00641 0.39 0.3542 0.8784 1910915 Bionet1_004594 Cc1ccc(C)n1c2ccsc2c3cc4ncc(cn4n3)c5ccc(C)cc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B17 compound treatment 0.259 -0.109 -5.56 0.203 -0.159 -9.57 -10.7024 -0.9666 1910916 Bionet1_004595 FC(F)(F)c1cnc(CC(=O)Nc2cccnc2Cl)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B18 compound treatment 0.367 -7.67E-4 -0.04 0.364 0.00241 0.15 0.075 0.4984 1910917 Bionet1_004596 FC(F)(F)c1cnc(CC(=O)Nc2cccc(Br)c2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B19 compound treatment 0.361 -0.00677 -0.35 0.369 0.00741 0.45 0.0715 0.1265 1910918 Bionet1_004597 [O-][N+](=O)c1ccc(C/2CCCC\C2=N/OC(=O)C3CCCC3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B20 compound treatment 0.388 0.0202 1.03 0.353 -0.00859 -0.52 0.3647 0.3151 1910919 Bionet1_004598 FC(F)(F)C(=O)C/C(=N\Nc1nc(cs1)c2ccccc2)/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B21 compound treatment 0.346 -0.0218 -1.11 0.359 -0.00259 -0.16 -0.8977 -0.7987 1910920 Bionet1_004599 [O-][N+](=O)c1ccc(C/2CCCC\C2=N/OC(=O)C3CCCCC3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B22 compound treatment 0.362 -0.00577 -0.29 0.354 -0.00759 -0.46 -0.5327 -0.9772 1279709 Bionet1_004600 Cc1c(C)c(OCC(=O)c2ccc(Cl)cc2)ccc1Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B23 positive control 0.087 -0.281 -14.36 0.092 -0.27 -16.27 -21.6595 -0.998 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 B24 positive control 0.089 -0.279 -14.25 0.092 -0.27 -16.27 -21.5872 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C01 mock treatment 0.383 0.0152 0.78 0.36 -0.00159 -0.1 0.4827 0.6151 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C02 mock treatment 0.368 2.33E-4 0.01 0.363 0.00141 0.08 0.0685 0.7986 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C03 compound treatment 0.365 -0.00277 -0.14 0.368 0.00641 0.39 0.1734 0.4212 1577911 Bionet1_004601 Cc1cc(C)c2c(n1)sc3c(Oc4ccccc4)nc(SCC=C)nc32 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C04 compound treatment 0.373 0.00523 0.27 0.373 0.0114 0.69 0.6761 0.9152 1910921 Bionet1_004602 Cc1ccc(cc1)C(=O)NNC(=O)c2cc3cc4ccccc4nc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C05 compound treatment 0.365 -0.00277 -0.14 0.362 4.06E-4 0.02 -0.0827 -0.5759 1514812 Bionet1_004603 Cc1cccc(Oc2nc(SCC=C)nc3c2sc4nc(C)cc(C)c43)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C06 compound treatment 0.382 0.0142 0.73 0.399 0.0374 2.26 2.1114 0.8899 1910922 Bionet1_004604 Clc1cccc(c1)C(=O)NNC(=O)c2cc3cc4ccccc4nc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C07 compound treatment 0.368 2.33E-4 0.01 0.375 0.0134 0.81 0.5807 0.7175 1910923 Bionet1_004605 CCSc1nc(Sc2ccccc2)c3sc4nc(C)cc(C)c4c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C08 compound treatment 0.362 -0.00577 -0.29 0.38 0.0184 1.11 0.5772 0.5021 1910924 Bionet1_004606 Cn1nc(c(/C=C(\C#N)/c2ccc(Cl)c(Cl)c2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C09 compound treatment 0.356 -0.0118 -0.6 0.37 0.00841 0.51 -0.0666 -0.0846 1910925 Bionet1_004607 Clc1cccc(Cl)c1CSc2nnc(/C=C/c3ccccc3)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C10 compound treatment 0.391 0.0232 1.19 0.381 0.0194 1.17 1.6684 1.0 1910926 Bionet1_004608 Fc1ccc(cc1)C(=O)NNC(=O)c2cc3cc4ccccc4nc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C11 compound treatment 0.363 -0.00477 -0.24 0.362 4.06E-4 0.02 -0.155 -0.6328 1910927 Bionet1_004609 COC(=O)c1ccc(CSc2nnc(/C=C/c3ccccc3)o2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C12 compound treatment 0.373 0.00523 0.27 0.391 0.0294 1.78 1.4445 0.8046 1910928 Bionet1_004610 Cc1cccc(c1)C(=O)NNC(=O)c2cc3cc4ccccc4nc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C13 compound treatment 0.354 -0.0138 -0.7 0.366 0.00441 0.27 -0.3097 -0.4115 1910929 Bionet1_004611 CCn1c(SCc2ccc(Cl)c(Cl)c2)nnc1/C=C/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C14 compound treatment 0.366 -0.00177 -0.09 0.364 0.00241 0.15 0.0388 0.2271 1910930 Bionet1_004612 COc1ccc(cc1OC)/C(=C/c2c(Cl)n(C)nc2C(F)(F)F)/C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C15 compound treatment 0.364 -0.00377 -0.19 0.369 0.00741 0.45 0.18 0.3697 1605754 Bionet1_004613 Cc1ccc(cc1)C(=O)Nc2ccc(N3CCN(CC3)c4ccccc4)c(F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C16 compound treatment 0.359 -0.00877 -0.45 0.365 0.00341 0.21 -0.1716 -0.3479 1910931 Bionet1_004614 CC(C(=O)Nc1cc(C)cc(C)n1)n2c(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C17 compound treatment 0.365 -0.00277 -0.14 0.371 0.00941 0.57 0.3015 0.5152 1477371 Bionet1_004615 Fc1ccc(cc1)C(=O)Nc2ccc(N3CCN(CC3)c4ccccc4)c(F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C18 compound treatment 0.356 -0.0118 -0.6 0.364 0.00241 0.15 -0.3227 -0.5214 1910932 Bionet1_004616 CC(C(=O)Nc1ccc(F)cc1F)n2c(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C19 compound treatment 0.364 -0.00377 -0.19 0.37 0.00841 0.51 0.2226 0.4102 1637918 Bionet1_004617 Cc1cccc(c1)C(=O)Nc2ccc(N3CCN(CC3)c4ccccc4)c(F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C20 compound treatment 0.359 -0.00877 -0.45 0.363 0.00141 0.08 -0.2569 -0.5632 1550909 Bionet1_004618 CS(=O)(=O)N1CCN(CC1)c2ccc(NC(=O)c3cccs3)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C21 compound treatment 0.372 0.00423 0.22 0.368 0.00641 0.39 0.4265 0.9624 1480987 Bionet1_004619 Fc1cc(NC(=O)Cc2ccccc2)ccc1N3CCN(CC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C22 compound treatment 0.363 -0.00477 -0.24 0.359 -0.00259 -0.16 -0.2831 -0.9771 1476598 Bionet1_004620 Cc1ccc(cc1)C(=O)Nc2ccc(N3CCN(CC3)S(=O)(=O)C)c(F)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C23 positive control 0.085 -0.283 -14.46 0.087 -0.275 -16.58 -21.9453 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 C24 positive control 0.089 -0.279 -14.25 0.094 -0.268 -16.15 -21.5018 -0.9981 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D01 mock treatment 0.359 -0.00877 -0.45 0.356 -0.00559 -0.34 -0.5557 -0.9902 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D02 mock treatment 0.359 -0.00877 -0.45 0.36 -0.00159 -0.1 -0.385 -0.8398 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D03 compound treatment 0.361 -0.00677 -0.35 0.363 0.00141 0.08 -0.1846 -0.5182 1910933 Bionet1_004621 [O-][N+](=O)c1ccc(C/2CCCC\C2=N/OC(=O)c3ccco3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D04 compound treatment 0.352 -0.0158 -0.81 0.362 4.06E-4 0.02 -0.5527 -0.6853 1910934 Bionet1_004622 Fc1ccc(cc1)c2cnn3c(cc(nc23)c4cccc(Cl)c4)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D05 compound treatment 0.352 -0.0158 -0.81 0.349 -0.0126 -0.76 -1.1076 -0.9996 1910935 Bionet1_004623 COc1cccc(c1)c2onc3ccc(cc23)C(=O)/C=C/c4ccc(C)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D06 compound treatment 0.349 -0.0188 -0.96 0.365 0.00341 0.21 -0.5331 -0.5432 1910936 Bionet1_004624 Nc1c(cnn1c2nc(cs2)c3ccccc3F)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D07 compound treatment 0.354 -0.0138 -0.7 0.364 0.00241 0.15 -0.395 -0.5496 1910937 Bionet1_004625 CC(Oc1ccc(Cl)cc1Cl)c2ccnc3c(Cl)c(C)nn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D08 compound treatment 0.35 -0.0178 -0.91 0.359 -0.00259 -0.16 -0.7531 -0.8169 1558024 Bionet1_004626 O=C(NCc1ccccc1)c2ccccc2C(=O)c3ccc4OCC(=O)Nc4c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D09 compound treatment 0.363 -0.00477 -0.24 0.366 0.00441 0.27 0.0157 0.0436 1910938 Bionet1_004627 Cc1cc(C)n(n1)c2nc(c(Sc3ccc(Cl)cc3)s2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D10 compound treatment 0.364 -0.00377 -0.19 0.36 -0.00159 -0.1 -0.2042 -0.9486 1910939 Bionet1_004628 Cc1ccccc1CSc2nc(c3CCCc3c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D11 compound treatment 0.356 -0.0118 -0.6 0.36 -0.00159 -0.1 -0.4935 -0.8099 1910940 Bionet1_004629 Cc1ccccc1C(=O)O/N=C/2\CCCCC2c3ccc(cc3[N+](=O)[O-])[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D12 compound treatment 0.355 -0.0128 -0.65 0.363 0.00141 0.08 -0.4016 -0.61 1910941 Bionet1_004630 Fc1cccc(Cl)c1CSc2nc(c3CCCc3c2C#N)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D13 compound treatment 0.368 2.33E-4 0.01 0.358 -0.00359 -0.22 -0.145 -0.6672 1910942 Bionet1_004631 [O-][N+](=O)c1ccc(C/2CCCC\C2=N/OC(=O)c3ccccc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D14 compound treatment 0.365 -0.00277 -0.14 0.362 4.06E-4 0.02 -0.0827 -0.5759 1910943 Bionet1_004632 Clc1cccc(CSc2nc(c3CCCc3c2C#N)c4ccccc4)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D15 compound treatment 0.357 -0.0108 -0.55 0.354 -0.00759 -0.46 -0.7134 -0.9959 1120862 Bionet1_004633 O=C(COc1cccc2c(OCC(=O)c3ccccc3)cccc12)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D16 compound treatment 0.359 -0.00877 -0.45 0.363 0.00141 0.08 -0.2569 -0.5632 1910944 Bionet1_004634 COC(=O)CC1COc2ccccc2N1C(=O)c3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D17 compound treatment 0.355 -0.0128 -0.65 0.359 -0.00259 -0.16 -0.5723 -0.8525 1374274 Bionet1_004635 CC(N1C(C(C)N(C)C1=O)c2ccccc2)S(=O)(=O)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D18 compound treatment 0.353 -0.0148 -0.76 0.354 -0.00759 -0.46 -0.8581 -0.9714 1910945 Bionet1_004636 Cc1ccc(cc1)c2nc(SCc3cccc(C)c3)c(C#N)c4CCCCc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D19 compound treatment 0.358 -0.00977 -0.5 0.364 0.00241 0.15 -0.2504 -0.4815 1910946 Bionet1_004637 COC(=O)CC(NC(=O)c1ccccc1F)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D20 compound treatment 0.362 -0.00577 -0.29 0.364 0.00241 0.15 -0.1058 -0.3218 1910947 Bionet1_004638 CC(C)(C)c1ccc(cc1)c2nc(SCc3ccccc3)c(C#N)c4CCCc42 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D21 compound treatment 0.362 -0.00577 -0.29 0.356 -0.00559 -0.34 -0.4473 -0.9977 1910948 Bionet1_004639 COC(=O)CC(NC(=O)c1ccco1)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D22 compound treatment 0.358 -0.00977 -0.5 0.367 0.00541 0.33 -0.1223 -0.2051 1443206 Bionet1_004640 Cc1cc(C)cc(NC(=O)Cc2ccc(OC(=O)c3ccccc3C)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D23 positive control 0.087 -0.281 -14.36 0.088 -0.274 -16.52 -21.8303 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 D24 positive control 0.091 -0.277 -14.15 0.094 -0.268 -16.15 -21.4295 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E01 mock treatment 0.378 0.0102 0.52 0.362 4.06E-4 0.02 0.3873 0.7394 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E02 mock treatment 0.372 0.00423 0.22 0.366 0.00441 0.27 0.3411 0.9948 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E03 compound treatment 0.341 -0.0268 -1.37 0.363 0.00141 0.08 -0.9077 -0.662 1910949 Bionet1_004641 Fc1ccc(CSc2nnc(/C=C/c3ccccc3)n2CC=C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E04 compound treatment 0.36 -0.00777 -0.4 0.37 0.00841 0.51 0.078 0.1211 1207756 Bionet1_004642 CS(=O)(=O)N1CCN(CC1)c2ccccc2NC(=O)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E05 compound treatment 0.357 -0.0108 -0.55 0.362 4.06E-4 0.02 -0.3719 -0.6749 1910950 Bionet1_004643 CCn1c(SCc2cccc(c2)[N+](=O)[O-])nnc1/C=C/c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E06 compound treatment 0.357 -0.0108 -0.55 0.362 4.06E-4 0.02 -0.3719 -0.6749 1281345 Bionet1_004644 CS(=O)(=O)N1CCN(CC1)c2ccccc2NC(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E07 compound treatment 0.358 -0.00977 -0.5 0.37 0.00841 0.51 0.0057 0.008 1667059 Bionet1_004645 OC(COc1ccccc1C#N)CS(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E08 compound treatment 0.364 -0.00377 -0.19 0.361 -5.94E-4 -0.04 -0.1615 -0.8245 1418904 Bionet1_004646 Cc1cccc(c1)C(=O)Nc2ccccc2N3CCN(CC3)S(=O)(=O)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E09 compound treatment 0.36 -0.00777 -0.4 0.363 0.00141 0.08 -0.2208 -0.5437 1306452 Bionet1_004647 OC(COc1ccc(F)cc1Cl)CS(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E10 compound treatment 0.369 0.00123 0.06 0.374 0.0124 0.75 0.5742 0.7639 1180995 Bionet1_004648 CS(=O)(=O)N1CCN(CC1)c2ccccc2NC(=O)c3cccs3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E11 compound treatment 0.363 -0.00477 -0.24 0.354 -0.00759 -0.46 -0.4965 -0.9563 1729255 Bionet1_004649 OC(COc1ccc(C#N)cc1)CS(=O)(=O)c2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E12 compound treatment 0.348 -0.0198 -1.01 0.365 0.00341 0.21 -0.5693 -0.5519 1910951 Bionet1_004650 Clc1ccc(C(=O)c2cc3cc4ccccc4nc3s2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E13 compound treatment 0.353 -0.0148 -0.76 0.363 0.00141 0.08 -0.4739 -0.6237 1522784 Bionet1_004651 Cc1ccc(cc1)S(=O)(=O)CC(O)COc2ccc(F)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E14 compound treatment 0.345 -0.0228 -1.16 0.348 -0.0136 -0.82 -1.4034 -0.9854 1329072 Bionet1_004652 CN1CCN(CC1)c2ccc(NC(=O)CSc3ccc(Cl)cc3)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E15 compound treatment 0.347 -0.0208 -1.06 0.366 0.00441 0.27 -0.5628 -0.5141 1400891 Bionet1_004653 Cc1ccc(c(C)c1)S(=O)(=O)CC(O)COc2ccc(F)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E16 compound treatment 0.363 -0.00477 -0.24 0.361 -5.94E-4 -0.04 -0.1977 -0.8025 1273257 Bionet1_004654 COc1ccc(SCC(=O)Nc2ccc(N3CCN(C)CC3)c(F)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E17 compound treatment 0.366 -0.00177 -0.09 0.36 -0.00159 -0.1 -0.1319 -0.9995 1140815 Bionet1_004655 COc1ccccc1S(=O)(=O)CC(O)COc2ccc(F)cc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E18 compound treatment 0.357 -0.0108 -0.55 0.353 -0.00859 -0.52 -0.7561 -0.9996 1719581 Bionet1_004656 CN1CCN(CC1)c2ccc(NC(=O)CSc3ccc(C)cc3C)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E19 compound treatment 0.363 -0.00477 -0.24 0.366 0.00441 0.27 0.0157 0.0436 1662007 Bionet1_004657 COc1ccccc1S(=O)(=O)CC(O)COc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E20 compound treatment 0.389 0.0212 1.09 0.374 0.0124 0.75 1.2973 0.9836 1910952 Bionet1_004658 Cc1ccc(SCC(=O)Nc2ccc(N3CCOCC3)c(F)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E21 compound treatment 0.38 0.0122 0.63 0.37 0.00841 0.51 0.8011 0.9946 1910953 Bionet1_004659 CC(=O)N1C(C)(C)CC(=NOC(=O)c2cccc(c2)C(F)(F)F)CC1(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E22 compound treatment 0.367 -7.67E-4 -0.04 0.365 0.00341 0.21 0.1177 0.5622 1910954 Bionet1_004660 COc1ccccc1N2CCN(CC2)/C(=C/C(=O)Nc3ccccc3C)/C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E23 positive control 0.088 -0.28 -14.31 0.089 -0.273 -16.46 -21.7514 -0.9976 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 E24 positive control 0.094 -0.274 -14.0 0.097 -0.265 -15.97 -21.193 -0.9978 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F01 mock treatment 0.391 0.0232 1.19 0.366 0.00441 0.27 1.0281 0.8445 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F02 mock treatment 0.37 0.00223 0.11 0.37 0.00841 0.51 0.4396 0.8451 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F03 compound treatment 0.368 2.33E-4 0.01 0.367 0.00541 0.33 0.2392 0.7325 1623599 Bionet1_004661 COC(=O)c1ccc(NS(=O)(=O)c2ccc(OC)cc2)cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F04 compound treatment 0.381 0.0132 0.68 0.375 0.0134 0.81 1.0507 0.996 1910955 Bionet1_004662 COC(=O)/C(=C\Nc1ccc(OCc2ccccc2)cc1)/n3cncn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F05 compound treatment 0.366 -0.00177 -0.09 0.379 0.0174 1.05 0.6791 0.6439 1910956 Bionet1_004663 Cc1ccc2SCC/C(=N\OC(=O)c3cccc(c3)C(F)(F)F)/c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F06 compound treatment 0.375 0.00723 0.37 0.354 -0.00759 -0.46 -0.0626 -0.1063 1910957 Bionet1_004664 Cc1cc(n(n1)c2nc(c(CC(=O)NN)s2)c3ccccc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F07 compound treatment 0.357 -0.0108 -0.55 0.362 4.06E-4 0.02 -0.3719 -0.6749 1649261 Bionet1_004665 Clc1ccc(cc1Cl)C(=O)Nc2cccc(Cl)c2N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F08 compound treatment 0.381 0.0132 0.68 0.384 0.0224 1.35 1.4349 0.9487 1910958 Bionet1_004666 Cc1cc2nc(cc(n2n1)C(F)(F)Cl)c3ccc(cc3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F09 compound treatment 0.356 -0.0118 -0.6 0.366 0.00441 0.27 -0.2373 -0.3608 1910959 Bionet1_004667 [O-][N+](=O)c1cccc(c1)C(=O)Nc2cccc(Cl)c2N3CCCCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F10 compound treatment 0.359 -0.00877 -0.45 0.376 0.0144 0.87 0.298 0.3046 1910960 Bionet1_004668 Cc1nn2c(cc(nc2c1Cl)c3ccc(cc3)C(F)(F)F)C(F)(F)Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F11 compound treatment 0.364 -0.00377 -0.19 0.367 0.00541 0.33 0.0946 0.2496 1910961 Bionet1_004669 FC(F)(F)c1cccc(OCc2nnc(S)n2c3ccccc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F12 compound treatment 0.362 -0.00577 -0.29 0.381 0.0194 1.17 0.6199 0.5131 1345982 Bionet1_004670 COC(=O)c1sccc1n2cc(nn2)C(=O)c3ccc(cc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F13 compound treatment 0.369 0.00123 0.06 0.38 0.0184 1.11 0.8303 0.746 1910962 Bionet1_004671 CSc1nnc(COc2cccc(c2)C(F)(F)F)n1c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F14 compound treatment 0.395 0.0272 1.39 0.39 0.0284 1.71 2.1972 0.9947 1910963 Bionet1_004672 COC(=O)C/1=C(C)N(CCc2ccc(OC)c(OC)c2)C(=O)\C1=C/N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F15 compound treatment 0.369 0.00123 0.06 0.364 0.00241 0.15 0.1473 0.9302 1910964 Bionet1_004673 NC(=O)CSc1nnc(COc2cccc3ccccc23)n1c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F16 compound treatment 0.398 0.0302 1.55 0.377 0.0154 0.93 1.7508 0.9704 1319443 Bionet1_004674 Cc1ccc(C)n1c2ccsc2c3cc4nccc(c5cccnc5)n4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F17 compound treatment 0.35 -0.0178 -0.91 0.362 4.06E-4 0.02 -0.625 -0.6878 1280661 Bionet1_004675 OC(COc1ccc(C#N)cc1)CN2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F18 compound treatment 0.374 0.00623 0.32 0.361 -5.94E-4 -0.04 0.2 0.6237 1910965 Bionet1_004676 Cc1nn(c(C)c1Cl)c2nc(c(Cl)s2)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F19 compound treatment 0.371 0.00323 0.17 0.381 0.0194 1.17 0.9453 0.799 1910966 Bionet1_004677 FC(F)(F)c1ccc(cc1)C(=O)Nc2ccc(nc2)N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F20 compound treatment 0.359 -0.00877 -0.45 0.364 0.00241 0.15 -0.2143 -0.4547 1910967 Bionet1_004678 FC(F)(F)C1=NCCN(C=C1)S(=O)(=O)c2ccc3ccccc3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F21 compound treatment 0.36 -0.00777 -0.4 0.366 0.00441 0.27 -0.0927 -0.194 1678897 Bionet1_004679 Cc1ccc2SCC(NC(=O)c3ccc(Cl)cc3Cl)C(=O)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F22 compound treatment 0.396 0.0282 1.44 0.383 0.0214 1.29 1.9346 0.9985 1910968 Bionet1_004680 CCC(CC)C(=O)c1c[nH]c(c1)C(=O)NCc2cccc(c2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F23 positive control 0.092 -0.276 -14.1 0.089 -0.273 -16.46 -21.6068 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 F24 positive control 0.093 -0.275 -14.05 0.098 -0.264 -15.91 -21.1865 -0.9981 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G01 mock treatment 0.358 -0.00977 -0.5 0.358 -0.00359 -0.22 -0.5065 -0.9303 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G02 mock treatment 0.361 -0.00677 -0.35 0.36 -0.00159 -0.1 -0.3127 -0.8707 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G03 compound treatment 0.356 -0.0118 -0.6 0.352 -0.00959 -0.58 -0.835 -0.9998 1910969 Bionet1_004681 CC(=O)N1C(C)(C)CC(=NOS(=O)(=O)c2ccccc2)CC1(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G04 compound treatment 0.356 -0.0118 -0.6 0.362 4.06E-4 0.02 -0.4081 -0.6777 1910970 Bionet1_004682 COC(=O)C(CSC1=NCCS1)NC(=O)OCc2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G05 compound treatment 0.359 -0.00877 -0.45 0.352 -0.00959 -0.58 -0.7265 -0.992 1910971 Bionet1_004683 COc1ccc(cc1)S(=O)(=O)ON=C2CC(C)(C)N(C(=O)C)C(C)(C)C2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G06 compound treatment 0.35 -0.0178 -0.91 0.353 -0.00859 -0.52 -1.0092 -0.9647 1307047 Bionet1_004684 Clc1ccc(COc2ccc(cc2)c3ccnc4ncnn34)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G07 compound treatment 0.366 -0.00177 -0.09 0.367 0.00541 0.33 0.1669 0.4929 1910972 Bionet1_004685 CC(=O)N1C(C)(C)CC(=NOS(=O)(=O)c2ccc(Cl)cc2)CC1(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G08 compound treatment 0.363 -0.00477 -0.24 0.372 0.0104 0.63 0.2719 0.4035 1488121 Bionet1_004686 Cc1cc2nccc(c3ccc(OCc4ccc(Cl)cc4Cl)cc3)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G09 compound treatment 0.355 -0.0128 -0.65 0.359 -0.00259 -0.16 -0.5723 -0.8525 1186461 Bionet1_004687 OC(COc1ccccc1Cl)CS(=O)(=O)Cc2ccc(Cl)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G10 compound treatment 0.356 -0.0118 -0.6 0.361 -5.94E-4 -0.04 -0.4508 -0.7479 1497423 Bionet1_004688 O=C(COc1ccc(cc1)c2nccc(n2)c3cccs3)N4CCCCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G11 compound treatment 0.345 -0.0228 -1.16 0.357 -0.00459 -0.28 -1.0192 -0.8517 1480218 Bionet1_004689 OC(COc1ccccc1Cl)CS(=O)(=O)Cc2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G12 compound treatment 0.357 -0.0108 -0.55 0.368 0.00641 0.39 -0.1158 -0.1721 1426075 Bionet1_004690 COc1ccc(NC(=O)C(CC(C)C)N2Cc3ccccc3C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G13 compound treatment 0.361 -0.00677 -0.35 0.362 4.06E-4 0.02 -0.2273 -0.6553 1567341 Bionet1_004691 Cc1ccc(SCC2(O)CCN(CC2)C(=O)c3ccc(Cl)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G14 compound treatment 0.35 -0.0178 -0.91 0.359 -0.00259 -0.16 -0.7531 -0.8169 1569471 Bionet1_004692 COc1cccc(c1)C(=O)Nc2ccc(I)cn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G15 compound treatment 0.365 -0.00277 -0.14 0.362 4.06E-4 0.02 -0.0827 -0.5759 1556473 Bionet1_004693 COc1cccc(SCC2(O)CCN(CC2)C(=O)c3ccc(Cl)cc3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G16 compound treatment 0.36 -0.00777 -0.4 0.365 0.00341 0.21 -0.1354 -0.3028 1315474 Bionet1_004694 COc1cccc(c1)C(=O)Nc2ncc(I)cc2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G17 compound treatment 0.386 0.0182 0.93 0.385 0.0234 1.41 1.6584 0.9796 1910973 Bionet1_004695 COC(=O)C/1=C(C)N(CCc2c[nH]c3ccccc23)C(=O)\C1=C/N(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G18 compound treatment 0.366 -0.00177 -0.09 0.373 0.0114 0.69 0.423 0.6091 1910974 Bionet1_004696 Cc1ccc(NC(=O)C(Cc2ccccc2)N3CCS(=O)(=O)CC3)cc1C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G19 compound treatment 0.358 -0.00977 -0.5 0.368 0.00641 0.39 -0.0797 -0.1261 1910975 Bionet1_004697 FC(F)(F)c1cccc(c1)N2CCN(CC2)C3CCc4[nH]ccc4C3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G20 compound treatment 0.362 -0.00577 -0.29 0.371 0.00941 0.57 0.193 0.3017 1910976 Bionet1_004698 CCCCCC1CCC(CC1)c2ccc(NC(=O)c3ccc(cc3)[N+](=O)[O-])cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G21 compound treatment 0.364 -0.00377 -0.19 0.334 -0.0276 -1.67 -1.3141 -0.7836 1910977 Bionet1_004699 FC(F)(F)c1ccc(COc2ccc(cc2)c3ncc4C(=O)CCCc4n3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G22 compound treatment 0.361 -0.00677 -0.35 0.334 -0.0276 -1.67 -1.4225 -0.8361 1268980 Bionet1_004700 O=C(COc1ccc(cc1)c2nccc(n2)c3ccccn3)NC4CCCCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G23 positive control 0.095 -0.273 -13.95 0.089 -0.273 -16.46 -21.4983 -0.9966 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 G24 positive control 0.095 -0.273 -13.95 0.097 -0.265 -15.97 -21.1568 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H01 mock treatment 0.435 0.0672 3.44 0.372 0.0104 0.63 2.8751 0.8227 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H02 mock treatment 0.369 0.00123 0.06 0.37 0.00841 0.51 0.4034 0.7889 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H03 compound treatment 0.359 -0.00877 -0.45 0.373 0.0114 0.69 0.1699 0.2068 1910978 Bionet1_004701 COc1ccc(cc1)S(=O)(=O)O/N=C/2\CCSc3ccc(C)cc23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H04 compound treatment 0.358 -0.00977 -0.5 0.356 -0.00559 -0.34 -0.5919 -0.9818 1910979 Bionet1_004702 COC(=O)c1sccc1n2nnc(C(=O)c3ccc(Cl)cc3Cl)c2C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H05 compound treatment 0.358 -0.00977 -0.5 0.363 0.00141 0.08 -0.2931 -0.5786 1910980 Bionet1_004703 Cc1ccc2SCC/C(=N\OS(=O)(=O)c3ccc(Cl)cc3)/c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H06 compound treatment 0.367 -7.67E-4 -0.04 0.37 0.00841 0.51 0.3311 0.6505 1910981 Bionet1_004704 CSc1nc2nc(C)c(Cc3cccc(c3)C(F)(F)F)c(C)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H07 compound treatment 0.37 0.00223 0.11 0.378 0.0164 0.99 0.7811 0.7834 1411497 Bionet1_004705 Cc1ccc2SCC(NC(=O)c3ccc(Cl)c(Cl)c3)C(=O)c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H08 compound treatment 0.368 2.33E-4 0.01 0.362 4.06E-4 0.02 0.0258 0.9452 1910982 Bionet1_004706 COC(=O)c1sccc1n2cc(nn2)C(=O)C(C)Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H09 compound treatment 0.391 0.0232 1.19 0.386 0.0244 1.47 1.8819 0.9943 1910983 Bionet1_004707 [O-][N+](=O)c1cccc(c1)C(=O)Nc2cc(Cl)ccc2N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H10 compound treatment 0.36 -0.00777 -0.4 0.357 -0.00459 -0.28 -0.4769 -0.9846 1613707 Bionet1_004708 O=C1CC(C(C(=O)C1C2NCCc3ccccc23)n4cncn4)c5ccco5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H11 compound treatment 0.357 -0.0108 -0.55 0.375 0.0134 0.81 0.183 0.187 1508254 Bionet1_004709 CN1CCN(CC1)c2ccc(Cl)cc2NC(=O)c3ccc(Cl)c(Cl)c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H12 compound treatment 0.364 -0.00377 -0.19 0.354 -0.00759 -0.46 -0.4603 -0.9258 1910984 Bionet1_004710 Cc1ccc(C)n1c2ccsc2c3cc4nccc(n4n3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H13 compound treatment 0.36 -0.00777 -0.4 0.358 -0.00359 -0.22 -0.4342 -0.9595 1910985 Bionet1_004711 CN1CCN(CC1)c2ccc(Cl)cc2NC(=O)c3cccc(c3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H14 compound treatment 0.376 0.00823 0.42 0.375 0.0134 0.81 0.87 0.9536 1670767 Bionet1_004712 CCC(CC)C(=O)c1c[nH]c(c1)C(=O)N2CCN(CC2)c3ccc(OC)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H15 compound treatment 0.356 -0.0118 -0.6 0.37 0.00841 0.51 -0.0666 -0.0846 1181310 Bionet1_004713 CN1CCN(CC1)c2ccc(Cl)cc2NC(=O)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H16 compound treatment 0.37 0.00223 0.11 0.373 0.0114 0.69 0.5676 0.8133 1910986 Bionet1_004714 Cc1ccccc1C(=O)c2c[nH]c(c2)C(=O)NCCCN3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H17 compound treatment 0.388 0.0202 1.03 0.391 0.0294 1.78 1.9868 0.967 1638690 Bionet1_004715 Clc1ccc(C(=O)Nc2cc(Cl)ccc2N3CCCCCC3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H18 compound treatment 0.396 0.0282 1.44 0.383 0.0214 1.29 1.9346 0.9985 1271631 Bionet1_004716 CCC(CC)C(=O)c1c[nH]c(c1)C(=O)N2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H19 compound treatment 0.398 0.0302 1.55 0.381 0.0194 1.17 1.9215 0.9906 1910987 Bionet1_004717 CCn1c(COc2cccc(c2)C(F)(F)F)nnc1SCC(=O)N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H20 compound treatment 0.382 0.0142 0.73 0.386 0.0244 1.47 1.5564 0.9471 1910988 Bionet1_004718 Cc1ccccc1C(=O)c2c[nH]c(c2)C(=O)NCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H21 compound treatment 0.371 0.00323 0.17 0.366 0.00441 0.27 0.305 0.9738 1692808 Bionet1_004719 OC(COc1ccc(C#N)cc1)CN2CCN(CC2)c3ccc(F)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H22 compound treatment 0.366 -0.00177 -0.09 0.374 0.0124 0.75 0.4657 0.6173 1910989 Bionet1_004720 O=C(Cc1ccccc1)c2c[nH]c(c2)C(=O)NCCCN3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H23 positive control 0.093 -0.275 -14.05 0.09 -0.272 -16.4 -21.528 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 H24 positive control 0.096 -0.272 -13.9 0.096 -0.266 -16.03 -21.1634 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I01 mock treatment 0.379 0.0112 0.57 0.357 -0.00459 -0.28 0.2101 0.3293 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I02 mock treatment 0.362 -0.00577 -0.29 0.366 0.00441 0.27 -0.0204 -0.0514 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I03 compound treatment 0.365 -0.00277 -0.14 0.369 0.00741 0.45 0.2161 0.4609 1407517 Bionet1_004721 Fc1cccc(Cl)c1COc2ccc(cc2)c3ccnc4ncnn34 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I04 compound treatment 0.365 -0.00277 -0.14 0.357 -0.00459 -0.28 -0.2961 -0.9512 1133771 Bionet1_004722 O=C(COc1ccc(cc1)c2nccc(n2)c3ccccn3)NCc4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I05 compound treatment 0.375 0.00723 0.37 0.367 0.00541 0.33 0.4923 0.9981 1349838 Bionet1_004723 O=C(COc1ccc(cc1)c2nccc(n2)c3cccs3)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I06 compound treatment 0.35 -0.0178 -0.91 0.359 -0.00259 -0.16 -0.7531 -0.8169 1910990 Bionet1_004724 Fc1cc(Oc2ccccc2C=C3C(=O)NC(=O)NC3=O)ccc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I07 compound treatment 0.374 0.00623 0.32 0.377 0.0154 0.93 0.883 0.8982 1910991 Bionet1_004725 Cc1ccc(NC(=O)Cc2ncc(cc2Cl)C(F)(F)F)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I08 compound treatment 0.293 -0.0748 -3.82 0.333 -0.0286 -1.73 -3.9238 -0.9354 1910992 Bionet1_004726 ClC1=C(NC(=O)OCCCc2ccccc2)C(=O)c3ccccc3C1=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I09 compound treatment 0.355 -0.0128 -0.65 0.361 -5.94E-4 -0.04 -0.4869 -0.7448 1655921 Bionet1_004727 Cc1cccc(n1)n2cnc(c2)C(=O)Nc3ccc(cc3)N4CCOCC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I10 compound treatment 0.352 -0.0158 -0.81 0.367 0.00541 0.33 -0.3393 -0.3901 1910993 Bionet1_004728 [O-][N+](=O)c1ccc(C/2CCCC\C2=N\OCc3ccccc3F)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I11 compound treatment 0.359 -0.00877 -0.45 0.368 0.00641 0.39 -0.0435 -0.0735 1288077 Bionet1_004729 Cc1cccc(n1)n2cnc(c2)C(=O)N3CCN(CC3)c4cccc(Cl)c4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I12 compound treatment 0.352 -0.0158 -0.81 0.368 0.00641 0.39 -0.2966 -0.3317 1910994 Bionet1_004730 [O-][N+](=O)c1ccc(C/2CCCC\C2=N\OCc3ccc(F)cc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I13 compound treatment 0.347 -0.0208 -1.06 0.363 0.00141 0.08 -0.6908 -0.6485 1910995 Bionet1_004731 FC(F)(F)c1nc2cc(Cl)c(Cl)cc2nc1Oc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I14 compound treatment 0.409 0.0412 2.11 0.393 0.0314 1.9 2.8315 0.9986 1910996 Bionet1_004732 [O-][N+](=O)c1cc(cc([N+](=O)[O-])c1NCCN2CCNCC2)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I15 compound treatment 0.378 0.0102 0.52 0.378 0.0164 0.99 1.0703 0.9555 1910997 Bionet1_004733 Cc1ccc(C)n1c2ccsc2c3cc4nccc(c5ccccc5)n4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I16 compound treatment 0.336 -0.0318 -1.62 0.321 -0.0406 -2.45 -2.8814 -0.9801 1910998 Bionet1_004734 [O-][N+](=O)c1ccc(COC(=O)NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I17 compound treatment 0.372 0.00423 0.22 0.365 0.00341 0.21 0.2985 0.9997 1910999 Bionet1_004735 COCc1cc(O)n2nc(cc2n1)c3ccsc3n4c(C)ccc4C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I18 compound treatment 0.366 -0.00177 -0.09 0.373 0.0114 0.69 0.423 0.6091 1911000 Bionet1_004736 CC(=O)N1CCC(CC1)C(=O)NNc2ncc(cc2Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I19 compound treatment 0.375 0.00723 0.37 0.368 0.00641 0.39 0.535 0.9998 1911001 Bionet1_004737 CC(=O)C1=C(C)NC(=C(C1c2ccc(F)cc2)C(=O)OCc3ccccc3)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I20 compound treatment 0.358 -0.00977 -0.5 0.362 4.06E-4 0.02 -0.3358 -0.6716 1911002 Bionet1_004738 Fc1ccc(C/N=C/c2ccn(c2)c3ccc(Br)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I21 compound treatment 0.361 -0.00677 -0.35 0.375 0.0134 0.81 0.3276 0.3722 1911003 Bionet1_004739 Fc1ccc(OC(=O)/C=C/c2cc3OCOc3cc2Br)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I22 compound treatment 0.36 -0.00777 -0.4 0.369 0.00741 0.45 0.0353 0.0591 1911004 Bionet1_004740 Clc1ccc(/N=C/c2ccn(c2)c3ccc(Br)cc3)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I23 positive control 0.092 -0.276 -14.1 0.092 -0.27 -16.27 -21.4787 -0.9974 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 I24 positive control 0.097 -0.271 -13.84 0.097 -0.265 -15.97 -21.0845 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J01 mock treatment 0.358 -0.00977 -0.5 0.355 -0.00659 -0.4 -0.6346 -0.9937 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J02 mock treatment 0.375 0.00723 0.37 0.373 0.0114 0.69 0.7484 0.9575 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J03 compound treatment 0.362 -0.00577 -0.29 0.359 -0.00259 -0.16 -0.3192 -0.9561 1911005 Bionet1_004741 CO/N=C/c1ccc(N2CCN(CC2)C(=O)c3ccc(F)cc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J04 compound treatment 0.359 -0.00877 -0.45 0.372 0.0104 0.63 0.1272 0.1649 1651261 Bionet1_004742 Cc1ccccc1C(=O)c2c[nH]c(c2)C(=O)N3CCN(CC3)c4ccccc4F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J05 compound treatment 0.366 -0.00177 -0.09 0.366 0.00441 0.27 0.1242 0.4422 1911006 Bionet1_004743 CO/N=C/c1ccc(N2CCN(CC2)C(=O)c3ccc(C)cc3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J06 compound treatment 0.363 -0.00477 -0.24 0.363 0.00141 0.08 -0.1123 -0.4352 1298358 Bionet1_004744 CCn1cc(n(Cc2ccccc2C)c1=O)S(=O)(=O)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J07 compound treatment 0.352 -0.0158 -0.81 0.365 0.00341 0.21 -0.4247 -0.5104 1911007 Bionet1_004745 CO/N=C/c1ccc(N2CCN(CC2)C(=O)c3cccs3)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J08 compound treatment 0.37 0.00223 0.11 0.369 0.00741 0.45 0.3969 0.8601 1476365 Bionet1_004746 Fc1ccc(cc1)N2CCN(Cc3cnc(s3)N4CCOCC4)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J09 compound treatment 0.359 -0.00877 -0.45 0.367 0.00541 0.33 -0.0862 -0.1554 1911008 Bionet1_004747 Clc1ccc(c(Cl)c1)S(=O)(=O)Nc2ccc(cc2)n3cccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J10 compound treatment 0.36 -0.00777 -0.4 0.375 0.0134 0.81 0.2915 0.3233 1911009 Bionet1_004748 FC(F)(F)c1cccc(NC(=O)Nc2nccc(n2)c3cccs3)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J11 compound treatment 0.356 -0.0118 -0.6 0.369 0.00741 0.45 -0.1093 -0.1458 1911010 Bionet1_004749 FC(F)(F)c1c(cnn1c2ccccc2)C(=O)N3CCN(CC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J12 compound treatment 0.367 -7.67E-4 -0.04 0.362 4.06E-4 0.02 -0.0104 -0.2244 1911011 Bionet1_004750 Cc1cc(n(n1)c2nc(cs2)c3ccc(cc3)[N+](=O)[O-])C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J13 compound treatment 0.347 -0.0208 -1.06 0.362 4.06E-4 0.02 -0.7335 -0.6906 1911012 Bionet1_004751 COc1ccc(NC(=O)c2cnn(c2C(F)(F)F)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J14 compound treatment 0.372 0.00423 0.22 0.361 -5.94E-4 -0.04 0.1277 0.5821 1372053 Bionet1_004752 CCOC(=O)c1cnc(SC)nc1Oc2cccc(NS(=O)(=O)C)c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J15 compound treatment 0.365 -0.00277 -0.14 0.37 0.00841 0.51 0.2588 0.4913 1911013 Bionet1_004753 CO/N=C\c1ccc(Sc2c(Cl)cccc2Cl)c(c1)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J16 compound treatment 0.376 0.00823 0.42 0.38 0.0184 1.11 1.0834 0.9118 1911014 Bionet1_004754 CC(OC(=O)Nc1ccccc1)c2sc(nc2C)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J17 compound treatment 0.373 0.00523 0.27 0.391 0.0294 1.78 1.4445 0.8046 1911015 Bionet1_004755 CO/N=C/c1cc(ccc1Sc2c(Cl)cccc2Cl)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J18 compound treatment 0.367 -7.67E-4 -0.04 0.365 0.00341 0.21 0.1177 0.5622 1190390 Bionet1_004756 CCSc1nc(Oc2ccc(C)cc2)c3sc4nc(C)cc(C)c4c3n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J19 compound treatment 0.354 -0.0138 -0.7 0.364 0.00241 0.15 -0.395 -0.5496 1911016 Bionet1_004757 CO/N=C/c1cc(ccc1Sc2cccc(Cl)c2Cl)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J20 compound treatment 0.357 -0.0108 -0.55 0.367 0.00541 0.33 -0.1585 -0.2477 1911017 Bionet1_004758 Clc1ccc(CSc2nc3ccccc3cc2/C=N/OC(=O)C4CC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J21 compound treatment 0.325 -0.0428 -2.19 0.349 -0.0126 -0.76 -2.0839 -0.9001 1637414 Bionet1_004759 Cc1ccc(C)n1c2ccccc2CNS(=O)(=O)Cc3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J22 compound treatment 0.376 0.00823 0.42 0.373 0.0114 0.69 0.7846 0.9721 1911018 Bionet1_004760 Fc1ccc(CNC(=O)c2cc(c[nH]2)C(=O)c3cccc(c3)C(F)(F)F)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J23 positive control 0.094 -0.274 -14.0 0.091 -0.271 -16.34 -21.4491 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 J24 positive control 0.098 -0.27 -13.79 0.098 -0.264 -15.91 -21.0057 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K01 mock treatment 0.362 -0.00577 -0.29 0.358 -0.00359 -0.22 -0.3619 -0.9886 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K02 mock treatment 0.373 0.00523 0.27 0.362 4.06E-4 0.02 0.2066 0.7687 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K03 compound treatment 0.366 -0.00177 -0.09 0.369 0.00741 0.45 0.2523 0.5531 1911019 Bionet1_004761 Fc1ccc(OC(=O)/C=C/c2cc3OCOc3cc2Br)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K04 compound treatment 0.386 0.0182 0.93 0.369 0.00741 0.45 0.9754 0.9433 1911020 Bionet1_004762 CCc1ccc(CSC2=Nc3cc(OC)c(OC)cc3C4=NC(=O)CN42)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K05 compound treatment 0.347 -0.0208 -1.06 0.371 0.00941 0.57 -0.3493 -0.2901 1911021 Bionet1_004763 Fc1cccc(OC(=O)/C=C/c2cc3OCOc3cc2Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K06 compound treatment 0.377 0.00923 0.47 0.366 0.00441 0.27 0.5219 0.9632 1911022 Bionet1_004764 COc1cc2N=C(SCc3ccccc3F)N4CC(=O)N=C4c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K07 compound treatment 0.392 0.0242 1.24 0.395 0.0334 2.02 2.3022 0.9726 1911023 Bionet1_004765 Clc1ccc(NC(=O)NNC(=O)C2CC(=NO2)c3cccs3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K08 compound treatment 0.38 0.0122 0.63 0.376 0.0144 0.87 1.0573 0.9869 1911024 Bionet1_004766 COc1cc2N=C(SCCC(=C(F)F)F)N3CC(=O)N=C3c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K09 compound treatment 0.362 -0.00577 -0.29 0.364 0.00241 0.15 -0.1058 -0.3218 1911025 Bionet1_004767 Clc1cccc(OC(=O)/C=C/c2cc3OCOc3cc2Br)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K10 compound treatment 0.367 -7.67E-4 -0.04 0.371 0.00941 0.57 0.3738 0.6567 1341233 Bionet1_004768 O=C(C1CCC(=O)N(C2CCCCC2)C1c3ccccc3)n4ccnc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K11 compound treatment 0.352 -0.0158 -0.81 0.36 -0.00159 -0.1 -0.6381 -0.7859 1676386 Bionet1_004769 COc1ccc(CNC(=O)c2c(C)onc2c3ccccc3Cl)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K12 compound treatment 0.37 0.00223 0.11 0.369 0.00741 0.45 0.3969 0.8601 1458254 Bionet1_004770 Cc1cc2nccc(c3ccccc3OCc4ccc(Cl)cc4)n2n1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K13 compound treatment 0.352 -0.0158 -0.81 0.35 -0.0116 -0.7 -1.065 -0.9975 1911026 Bionet1_004771 FC(F)(F)C1=NCCN(C=C1)S(=O)(=O)c2ccc(Br)cc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K14 compound treatment 0.363 -0.00477 -0.24 0.356 -0.00559 -0.34 -0.4111 -0.9872 1125401 Bionet1_004772 Clc1ccc(COc2ccccc2c3ccn(n3)C(=O)c4cccs4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K15 compound treatment 0.391 0.0232 1.19 0.397 0.0354 2.14 2.3514 0.9616 1911027 Bionet1_004773 Clc1cccc(c1)C(=O)NNC(=O)c2cc3c(ccc4ccccc34)o2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K16 compound treatment 0.361 -0.00677 -0.35 0.372 0.0104 0.63 0.1996 0.2782 1440171 Bionet1_004774 Clc1ccc(COc2ccccc2c3ccnc4c(C#N)cnn34)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K17 compound treatment 0.385 0.0172 0.88 0.386 0.0244 1.47 1.6649 0.9698 1911028 Bionet1_004775 COc1ccc(CNc2ccc(cc2[N+](=O)[O-])C(F)(F)F)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K18 compound treatment 0.36 -0.00777 -0.4 0.373 0.0114 0.69 0.2061 0.2593 1191209 Bionet1_004776 Cc1ccc(Cn2ccc(n2)c3ccccc3OCc4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K19 compound treatment 0.404 0.0362 1.85 0.406 0.0444 2.68 3.2056 0.9837 1394166 Bionet1_004777 Clc1ccc(cc1Cl)S(=O)(=O)Nc2ccc3nccnc3c2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K20 compound treatment 0.368 2.33E-4 0.01 0.367 0.00541 0.33 0.2392 0.7325 1265290 Bionet1_004778 Fc1ccc(Cn2ccc(n2)c3ccccc3OCc4ccc(Cl)cc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K21 compound treatment 0.358 -0.00977 -0.5 0.359 -0.00259 -0.16 -0.4638 -0.8863 1911029 Bionet1_004779 COC(=O)CC(NC(=O)Nc1ccc(C)cc1)c2cccc(c2)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K22 compound treatment 0.382 0.0142 0.73 0.366 0.00441 0.27 0.7027 0.9069 1472238 Bionet1_004780 Clc1ccc(COc2ccccc2c3ccnc(n3)c4ccncc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K23 positive control 0.095 -0.273 -13.95 0.09 -0.272 -16.4 -21.4556 -0.9968 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 K24 positive control 0.102 -0.266 -13.59 0.098 -0.264 -15.91 -20.8611 -0.9969 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L01 mock treatment 0.359 -0.00877 -0.45 0.363 0.00141 0.08 -0.2569 -0.5632 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L02 mock treatment 0.369 0.00123 0.06 0.361 -5.94E-4 -0.04 0.0192 0.2653 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L03 compound treatment 0.368 2.33E-4 0.01 0.373 0.0114 0.69 0.4953 0.7193 1204451 Bionet1_004781 Cc1ccc(C)n1c2ccccc2CNS(=O)(=O)c3ccc(C)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L04 compound treatment 0.379 0.0112 0.57 0.392 0.0304 1.84 1.7041 0.886 1911030 Bionet1_004782 FC(F)(F)c1cccc(c1)C(=O)c2c[nH]c(c2)C(=O)NCC3CCCO3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L05 compound treatment 0.38 0.0122 0.63 0.371 0.00941 0.57 0.8438 0.9988 1911031 Bionet1_004783 Fc1ccc(NC(=O)c2cnn(c2C(F)(F)F)c3ccccc3)c(F)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L06 compound treatment 0.362 -0.00577 -0.29 0.365 0.00341 0.21 -0.0631 -0.1755 1911032 Bionet1_004784 FC(F)(F)c1cccc(c1)C(=O)c2c[nH]c(c2)C(=O)NCCc3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L07 compound treatment 0.361 -0.00677 -0.35 0.362 4.06E-4 0.02 -0.2273 -0.6553 1183297 Bionet1_004785 Clc1ccc(CSc2nnc3c4ccccc4[nH]c3n2)cc1Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L08 compound treatment 0.371 0.00323 0.17 0.379 0.0174 1.05 0.8599 0.8084 1118867 Bionet1_004786 CC(C)(C)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCc3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L09 compound treatment 0.372 0.00423 0.22 0.37 0.00841 0.51 0.5119 0.9278 1911033 Bionet1_004787 Clc1ccc(cc1)c2nc3sc4CCCCc4n3c2/C=N/OC(=O)C5CC5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L10 compound treatment 0.386 0.0182 0.93 0.392 0.0304 1.84 1.9572 0.9507 1123564 Bionet1_004788 CC(C)(C)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCCc3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L11 compound treatment 0.378 0.0102 0.52 0.358 -0.00359 -0.22 0.2166 0.3824 1670271 Bionet1_004789 Clc1cccc(Cl)c1Cn2nc-3c(CCc4ccccc43)cc2=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L12 compound treatment 0.361 -0.00677 -0.35 0.364 0.00241 0.15 -0.1419 -0.3783 1911034 Bionet1_004790 FC(F)(F)c1cccc(c1)C(=O)c2c[nH]c(c2)C(=O)NCc3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L13 compound treatment 0.36 -0.00777 -0.4 0.353 -0.00859 -0.52 -0.6477 -0.9913 1911035 Bionet1_004791 Clc1ccc(/C=C/c2nnc(SCc3ccccc3)o2)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L14 compound treatment 0.359 -0.00877 -0.45 0.356 -0.00559 -0.34 -0.5557 -0.9902 1911036 Bionet1_004792 CC(C)(C)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCCCn3ccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L15 compound treatment 0.361 -0.00677 -0.35 0.362 4.06E-4 0.02 -0.2273 -0.6553 1911037 Bionet1_004793 CO/N=C(\CSc1ccc(Cl)cc1)/c2c(C)nc3cc(C)ccn23 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L16 compound treatment 0.371 0.00323 0.17 0.365 0.00341 0.21 0.2623 0.9942 1911038 Bionet1_004794 CC(C)(C)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCCCN3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L17 compound treatment 0.358 -0.00977 -0.5 0.359 -0.00259 -0.16 -0.4638 -0.8863 1911039 Bionet1_004795 Clc1cccc(Cl)c1CSc2cc3CCc4ccccc4-c3nn2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L18 compound treatment 0.36 -0.00777 -0.4 0.366 0.00441 0.27 -0.0927 -0.194 1911040 Bionet1_004796 Fc1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCCCN3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L19 compound treatment 0.367 -7.67E-4 -0.04 0.364 0.00241 0.15 0.075 0.4984 1911041 Bionet1_004797 FC(F)(F)c1nnc(nc1Sc2ccc(Cl)cc2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L20 compound treatment 0.37 0.00223 0.11 0.38 0.0184 1.11 0.8665 0.7757 1256599 Bionet1_004798 COc1ccc(CNC(=O)c2cc(c[nH]2)C(=O)c3ccc(F)cc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L21 compound treatment 0.361 -0.00677 -0.35 0.363 0.00141 0.08 -0.1846 -0.5182 1911042 Bionet1_004799 COC(=O)c1ccccc1NC(=O)Cn2c(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L22 compound treatment 0.37 0.00223 0.11 0.365 0.00341 0.21 0.2262 0.9615 1911043 Bionet1_004800 CN(C)CCCNC(=O)c1cc(c[nH]1)C(=O)c2ccc(cc2)C(C)(C)C 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L23 positive control 0.093 -0.275 -14.05 0.09 -0.272 -16.4 -21.528 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 L24 positive control 0.098 -0.27 -13.79 0.098 -0.264 -15.91 -21.0057 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M01 mock treatment 0.364 -0.00377 -0.19 0.365 0.00341 0.21 0.0092 0.0327 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M02 mock treatment 0.37 0.00223 0.11 0.361 -5.94E-4 -0.04 0.0554 0.4629 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M03 compound treatment 0.366 -0.00177 -0.09 0.396 0.0344 2.08 1.4048 0.6757 1911044 Bionet1_004801 Fc1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCc3cccc(c3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M04 compound treatment 0.361 -0.00677 -0.35 0.357 -0.00459 -0.28 -0.4407 -0.994 1142783 Bionet1_004802 Clc1ccc(COc2ccccc2c3ccnc(n3)c4ccccn4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M05 compound treatment 0.346 -0.0218 -1.11 0.37 0.00841 0.51 -0.4282 -0.35 1911045 Bionet1_004803 Cc1ccc(C)n1c2sccc2c3cc4nc(C)c(Cl)c(C)n4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M06 compound treatment 0.361 -0.00677 -0.35 0.359 -0.00259 -0.16 -0.3554 -0.9357 1911046 Bionet1_004804 FC(F)(F)c1ccc(cc1)C(=O)c2c[nH]c(c2)C(=O)NCCCn3ccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M07 compound treatment 0.367 -7.67E-4 -0.04 0.362 4.06E-4 0.02 -0.0104 -0.2244 1911047 Bionet1_004805 CCOC(=O)CC1COc2ccccc2N1C(=O)c3cccc(c3)[N+](=O)[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M08 compound treatment 0.387 0.0192 0.98 0.385 0.0234 1.41 1.6945 0.9843 1487961 Bionet1_004806 Clc1ccc(C(=O)c2c[nH]c(c2)C(=O)NCCc3ccccc3)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M09 compound treatment 0.374 0.00623 0.32 0.366 0.00441 0.27 0.4135 0.996 1911048 Bionet1_004807 COC(=O)C1=C(C)N(CCc2ccc(OC)c(OC)c2)C(=O)C1/C=[N+](\C)/[O-] 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M10 compound treatment 0.379 0.0112 0.57 0.383 0.0214 1.29 1.3199 0.9334 1911049 Bionet1_004808 Fc1ccc(COc2ccccc2c3ccn(n3)C(=O)c4ccco4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M11 compound treatment 0.374 0.00623 0.32 0.371 0.00941 0.57 0.6269 0.9627 1911050 Bionet1_004809 Cc1nn2c(cc(nc2c1Br)c3cccs3)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M12 compound treatment 0.363 -0.00477 -0.24 0.369 0.00741 0.45 0.1438 0.2824 1186956 Bionet1_004810 Cc1ccc(C)n1c2ccsc2c3cc4nc(C)c(Cl)c(C)n4n3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M13 compound treatment 0.376 0.00823 0.42 0.379 0.0174 1.05 1.0407 0.9194 1563971 Bionet1_004811 Cc1ccc(C)n1c2ccsc2c3cc4nc(cc(O)n4n3)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M14 compound treatment 0.389 0.0212 1.09 0.387 0.0254 1.53 1.8522 0.9857 1468464 Bionet1_004812 Cc1nc2cc(nn2c(O)c1Cc3ccccc3)c4sccc4n5cccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M15 compound treatment 0.331 -0.0368 -1.88 0.366 0.00441 0.27 -1.1412 -0.6011 1911051 Bionet1_004813 Cc1nn2c(ccnc2c1Br)c3ccc(Cl)cc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M16 compound treatment 0.362 -0.00577 -0.29 0.361 -5.94E-4 -0.04 -0.2338 -0.7873 1291201 Bionet1_004814 Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc2ccnc(n2)c3cccnc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M17 compound treatment 0.37 0.00223 0.11 0.366 0.00441 0.27 0.2688 0.9287 1911052 Bionet1_004815 [O-][N+](=O)c1ccc(Cl)cc1C(=O)N2CCN(CC2)c3ccccc3F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M18 compound treatment 0.368 2.33E-4 0.01 0.376 0.0144 0.87 0.6234 0.7167 1437790 Bionet1_004816 CCOc1ccc(Oc2nc3ccccc3nc2Cc4ccccc4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M19 compound treatment 0.368 2.33E-4 0.01 0.342 -0.0196 -1.18 -0.828 -0.6999 1911053 Bionet1_004817 [O-][N+](=O)c1ccc(Cl)cc1C(=O)N2CCN(Cc3ccccc3)CC2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M20 compound treatment 0.37 0.00223 0.11 0.372 0.0104 0.63 0.525 0.8222 1911054 Bionet1_004818 FC(F)(F)c1cccc(c1)c2nc3c(C#N)c(ccn3n2)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M21 compound treatment 0.388 0.0202 1.03 0.38 0.0184 1.11 1.5173 0.9994 1609747 Bionet1_004819 CCC(CC)C(=O)c1c[nH]c(c1)C(=O)N2CCN(CC2)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M22 compound treatment 0.373 0.00523 0.27 0.368 0.00641 0.39 0.4627 0.9838 1384241 Bionet1_004820 Cc1ccc(cc1)C(=O)n2cc(CCN3CCS(=O)(=O)CC3)c4ccccc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M23 positive control 0.094 -0.274 -14.0 0.091 -0.271 -16.34 -21.4491 -0.997 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 M24 positive control 0.098 -0.27 -13.79 0.097 -0.265 -15.97 -21.0484 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N01 mock treatment 0.367 -7.67E-4 -0.04 0.366 0.00441 0.27 0.1604 0.5965 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N02 mock treatment 0.368 2.33E-4 0.01 0.368 0.00641 0.39 0.2819 0.7286 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N03 compound treatment 0.361 -0.00677 -0.35 0.365 0.00341 0.21 -0.0993 -0.2466 1911055 Bionet1_004821 CN(NC(=O)c1cccc(C)c1)c2nc(nnc2C(F)(F)F)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N04 compound treatment 0.369 0.00123 0.06 0.358 -0.00359 -0.22 -0.1088 -0.4816 1911056 Bionet1_004822 FC(F)(F)c1cccc(NC(=O)c2cc3cc4ccccc4nc3s2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N05 compound treatment 0.368 2.33E-4 0.01 0.367 0.00541 0.33 0.2392 0.7325 1911057 Bionet1_004823 Nc1c(cnn1c2nc(cs2)c3cccc(F)c3)c4ccc(F)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N06 compound treatment 0.364 -0.00377 -0.19 0.358 -0.00359 -0.22 -0.2896 -0.9982 1911058 Bionet1_004824 CC(C(=O)Nc1ccc(Cl)cn1)n2c(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N07 compound treatment 0.368 2.33E-4 0.01 0.368 0.00641 0.39 0.2819 0.7286 1911059 Bionet1_004825 CCOC(=O)c1cnn(c2nc(cs2)C(F)(F)F)c1C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N08 compound treatment 0.375 0.00723 0.37 0.365 0.00341 0.21 0.4069 0.9616 1911060 Bionet1_004826 COC(=O)c1ccccc1NC(=O)C(C)n2c(nc3ccccc23)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N09 compound treatment 0.371 0.00323 0.17 0.364 0.00241 0.15 0.2196 0.9979 1623232 Bionet1_004827 COC(=O)CC1COc2ccccc2N1C(=O)c3ccc(Br)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N10 compound treatment 0.378 0.0102 0.52 0.364 0.00241 0.15 0.4727 0.8705 1170896 Bionet1_004828 CCn1c(SCC=C)nnc1c2cc3cc4ccccc4nc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N11 compound treatment 0.393 0.0252 1.29 0.383 0.0214 1.29 1.8261 1.0 1620711 Bionet1_004829 Cc1cc(N2CCN(CC2)c3ccccc3)n4cc(nc4n1)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N12 compound treatment 0.371 0.00323 0.17 0.371 0.00941 0.57 0.5184 0.8766 1911061 Bionet1_004830 CCn1c(SCCCF)nnc1c2cc3cc4ccccc4nc3s2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N13 compound treatment 0.36 -0.00777 -0.4 0.361 -5.94E-4 -0.04 -0.3062 -0.7678 1561349 Bionet1_004831 Fc1ccccc1C(=O)Nc2cccn3c(cnc23)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N14 compound treatment 0.364 -0.00377 -0.19 0.365 0.00341 0.21 0.0092 0.0327 1911062 Bionet1_004832 Cn1nc(c(/C=N/c2ccc(Cl)c(Cl)c2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N15 compound treatment 0.366 -0.00177 -0.09 0.364 0.00241 0.15 0.0388 0.2271 1648942 Bionet1_004833 Cc1cc(N2CCN(CC2)c3ccccn3)n4cc(nc4n1)c5ccccc5 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N16 compound treatment 0.372 0.00423 0.22 0.367 0.00541 0.33 0.3838 0.9801 1911063 Bionet1_004834 Cn1nc(c(CNc2ccc(Cl)c(Cl)c2)c1Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N17 compound treatment 0.353 -0.0148 -0.76 0.374 0.0124 0.75 -0.0043 -0.0041 1911064 Bionet1_004835 Cc1ccccc1c2nc(SCc3ccccc3)c(C#N)c4CCCc42 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N18 compound treatment 0.366 -0.00177 -0.09 0.361 -5.94E-4 -0.04 -0.0892 -0.9181 1273314 Bionet1_004836 CN1CCN(CC1)c2ccc(NC(=O)CSc3ccccc3)cc2F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N19 compound treatment 0.347 -0.0208 -1.06 0.363 0.00141 0.08 -0.6908 -0.6485 1615160 Bionet1_004837 Cc1cc(C)cc(NC(=O)Cc2ccc(OC(=O)C3CCCCC3)cc2)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N20 compound treatment 0.373 0.00523 0.27 0.371 0.00941 0.57 0.5907 0.9411 1911065 Bionet1_004838 Fc1cc(NC(=O)CSc2ccc(Cl)cc2)ccc1N3CCOCC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N21 compound treatment 0.362 -0.00577 -0.29 0.409 0.0474 2.86 1.8151 0.6309 1911066 Bionet1_004839 Clc1ccc(cc1)c2nc(SCc3ccccc3)c(C#N)c4CCCCc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N22 compound treatment 0.382 0.0142 0.73 0.361 -5.94E-4 -0.04 0.4893 0.6715 1911067 Bionet1_004840 COc1ccc(SCC(=O)Nc2ccc(N3CCOCC3)c(F)c2)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N23 positive control 0.092 -0.276 -14.1 0.091 -0.271 -16.34 -21.5214 -0.9973 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 N24 positive control 0.099 -0.269 -13.74 0.096 -0.266 -16.03 -21.0549 -0.9971 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O01 mock treatment 0.374 0.00623 0.32 0.368 0.00641 0.39 0.4988 0.9954 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O02 mock treatment 0.366 -0.00177 -0.09 0.364 0.00241 0.15 0.0388 0.2271 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O03 compound treatment 0.369 0.00123 0.06 0.375 0.0134 0.81 0.6169 0.7599 1244191 Bionet1_004841 Cc1ccccc1C(=O)c2c[nH]c(c2)C(=O)N3CCN(Cc4ccccc4)CC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O04 compound treatment 0.377 0.00923 0.47 0.379 0.0174 1.05 1.0769 0.9348 1911068 Bionet1_004842 COc1cc2N=C(SCc3ccccc3C)N4CC(=O)N=C4c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O05 compound treatment 0.359 -0.00877 -0.45 0.363 0.00141 0.08 -0.2569 -0.5632 1911069 Bionet1_004843 FC(F)(F)c1cnc(NCCN2C(=O)C3C4OC(C=C4)C3C2=O)c(Cl)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O06 compound treatment 0.368 2.33E-4 0.01 0.368 0.00641 0.39 0.2819 0.7286 1911070 Bionet1_004844 CN(CCOc1ccc(C=C2C(=O)N(C)C(=O)N(C)C2=O)cc1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O07 compound treatment 0.37 0.00223 0.11 0.366 0.00441 0.27 0.2688 0.9287 1911071 Bionet1_004845 COC(=O)CC(NS(=O)(=O)c1cccs1)c2ccccc2Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O08 compound treatment 0.369 0.00123 0.06 0.371 0.00941 0.57 0.4461 0.7808 1911072 Bionet1_004846 CN(CCOc1ccc(C=C2C(=O)NC(=O)NC2=O)cc1)c3ccccn3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O09 compound treatment 0.372 0.00423 0.22 0.372 0.0104 0.63 0.5973 0.8989 1911073 Bionet1_004847 COc1cnc(nc1N2CCN(CC2)c3ccccc3F)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O10 compound treatment 0.37 0.00223 0.11 0.364 0.00241 0.15 0.1835 0.9929 1285744 Bionet1_004848 Cc1onc(c1C(=O)c2c[nH]c(c2)C(=O)NCc3ccncc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O11 compound treatment 0.365 -0.00277 -0.14 0.366 0.00441 0.27 0.0881 0.2923 1911074 Bionet1_004849 C/C(=N\OC(=O)c1ccc(F)cc1)/c2sc(nc2C)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O12 compound treatment 0.371 0.00323 0.17 0.368 0.00641 0.39 0.3904 0.9281 1336721 Bionet1_004850 Cc1onc(c1C(=O)c2c[nH]c(c2)C(=O)NCc3ccccn3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O13 compound treatment 0.366 -0.00177 -0.09 0.362 4.06E-4 0.02 -0.0465 -0.4971 1911075 Bionet1_004851 C/C(=N\OC(=O)c1ccc(C)cc1)/c2sc(nc2C)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O14 compound treatment 0.369 0.00123 0.06 0.368 0.00641 0.39 0.3181 0.8117 1911076 Bionet1_004852 COCCCNC(=O)c1cc(c[nH]1)C(=O)c2ccccc2Br 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O15 compound treatment 0.379 0.0112 0.57 0.378 0.0164 0.99 1.1065 0.9664 1911077 Bionet1_004853 C/C(=N\OC(=O)Nc1ccc(C)cc1)/c2sc(nc2C)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O16 compound treatment 0.37 0.00223 0.11 0.367 0.00541 0.33 0.3115 0.901 1169155 Bionet1_004854 O=C(NCc1cccs1)c2ccc(cc2)N3CCS(=O)(=O)CC3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O17 compound treatment 0.384 0.0162 0.83 0.366 0.00441 0.27 0.775 0.8892 1911078 Bionet1_004855 C/C(=N\OC(=O)NC1CCCCC1)/c2sc(nc2C)c3ccc(Cl)cc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O18 compound treatment 0.363 -0.00477 -0.24 0.368 0.00641 0.39 0.1011 0.2212 1597254 Bionet1_004856 Cc1ccc(cc1)C(=O)Nc2ncccc2S(=O)(=O)c3ccccc3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O19 compound treatment 0.375 0.00723 0.37 0.364 0.00241 0.15 0.3642 0.9167 1911079 Bionet1_004857 COC(=O)c1sc2ccccc2c1n3cccc3C(=O)C(=O)NC4CC4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O20 compound treatment 0.372 0.00423 0.22 0.371 0.00941 0.57 0.5546 0.9126 1911080 Bionet1_004858 COc1ccc(cc1)C2CC(=O)CC(=O)C2c3ncc(cc3Cl)C(F)(F)F 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O21 compound treatment 0.371 0.00323 0.17 0.367 0.00541 0.33 0.3477 0.9503 1231787 Bionet1_004859 Clc1ccc(Cn2nc(c3ccccc3)c(cc2=O)N4CCCCC4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O22 compound treatment 0.373 0.00523 0.27 0.36 -0.00159 -0.1 0.1212 0.4262 1126906 Bionet1_004860 Cc1nc2nc(C#N)c(C#N)n2c(C)c1Cc3c(Cl)cccc3Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O23 positive control 0.09 -0.278 -14.2 0.092 -0.27 -16.27 -21.5511 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 O24 positive control 0.096 -0.272 -13.9 0.096 -0.266 -16.03 -21.1634 -0.9975 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P01 mock treatment 0.386 0.0182 0.93 0.373 0.0114 0.69 1.1461 0.9889 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P02 mock treatment 0.369 0.00123 0.06 0.369 0.00741 0.45 0.3607 0.7989 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P03 compound treatment 0.386 0.0182 0.93 0.375 0.0134 0.81 1.2315 0.9975 1518831 Bionet1_004861 Cc1ccccc1c2nc(SCc3cccc(F)c3)c(C#N)c4CCCc42 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P04 compound treatment 0.354 -0.0138 -0.7 0.376 0.0144 0.87 0.1172 0.1048 1911081 Bionet1_004862 Fc1cc(NC(=O)CN2CCCCC2)ccc1N3CCN(CC3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P05 compound treatment 0.374 0.00623 0.32 0.382 0.0204 1.23 1.0965 0.8617 1911082 Bionet1_004863 COc1cc2C(NC(=O)C(F)(F)F)C(Br)C(=O)c2cc1OC 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P06 compound treatment 0.362 -0.00577 -0.29 0.382 0.0204 1.23 0.6626 0.5231 1911083 Bionet1_004864 CCN1CCN(CC(=O)Nc2ccc(N3CCOCC3)c(F)c2)CC1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P07 compound treatment 0.372 0.00423 0.22 0.372 0.0104 0.63 0.5973 0.8989 1911084 Bionet1_004865 BrC(Br)(C(=O)c1ccccc1)c2ccccc2 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P08 compound treatment 0.366 -0.00177 -0.09 0.369 0.00741 0.45 0.2523 0.5531 1546267 Bionet1_004866 Clc1ccc(CNC(=O)c2sccc2NC(=O)c3ccccc3)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P09 compound treatment 0.38 0.0122 0.63 0.393 0.0314 1.9 1.7829 0.893 1911085 Bionet1_004867 Cc1ccccc1c2nc(SCc3ccc(F)cc3)c(C#N)c4CCCc42 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P10 compound treatment 0.385 0.0172 0.88 0.391 0.0294 1.78 1.8784 0.9478 1911086 Bionet1_004868 [O-][N+](=O)c1ccccc1/C=N/c2oc(c(c2C#N)c3ccccc3)c4ccccc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P11 compound treatment 0.367 -7.67E-4 -0.04 0.384 0.0224 1.35 0.9287 0.6863 1911087 Bionet1_004869 Cc1ccc(CSc2nc(c3CCCc3c2C#N)c4ccccc4C)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P12 compound treatment 0.377 0.00923 0.47 0.373 0.0114 0.69 0.8207 0.9831 1911088 Bionet1_004870 CN(C)c1ccc(/C=C/C=N/c2oc(c3ccco3)c(c2C#N)c4ccco4)cc1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P13 compound treatment 0.372 0.00423 0.22 0.371 0.00941 0.57 0.5546 0.9126 1911089 Bionet1_004871 Ic1cc(I)c2oc(=O)[nH]c2c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P14 compound treatment 0.365 -0.00277 -0.14 0.367 0.00541 0.33 0.1307 0.3676 1247941 Bionet1_004872 O=C(NCc1ccco1)c2ccccc2C(=O)c3ccc4OCC(=O)Nc4c3 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P15 compound treatment 0.397 0.0292 1.49 0.381 0.0194 1.17 1.8854 0.9927 1911090 Bionet1_004873 Cc1ccc(cc1)c2nc3sccn3c2C=C4C(=O)OC(C)(C)OC4=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P16 compound treatment 0.353 -0.0148 -0.76 0.368 0.00641 0.39 -0.2604 -0.307 1911091 Bionet1_004874 Cc1ccc(cc1)c2nc(SCc3ccccc3)c(C#N)c4CCCCc24 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P17 compound treatment 0.38 0.0122 0.63 0.373 0.0114 0.69 0.9292 0.9989 1911092 Bionet1_004875 Cc1ccc(cc1)c2nc3sccn3c2/C=C/C(=O)c4ccc(Cl)cc4 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P18 compound treatment 0.378 0.0102 0.52 0.36 -0.00159 -0.1 0.302 0.5676 1520560 Bionet1_004876 COc1cc(cc(OC)c1OC)c2c3C(=O)c4ccccc4-c3nc(C)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P19 compound treatment 0.344 -0.0238 -1.22 0.368 0.00641 0.39 -0.5858 -0.4594 1911093 Bionet1_004877 Cc1ccc(cc1)c2nc3sccn3c2/C=N/OCc4c(F)cccc4Cl 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P20 compound treatment 0.343 -0.0248 -1.27 0.353 -0.00859 -0.52 -1.2623 -0.9224 1911094 Bionet1_004878 CCCCCCCc1ccc(cc1)C2C3=C(NC(=C2C#N)C)c4ccccc4C3=O 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P21 compound treatment 0.372 0.00423 0.22 0.163 -0.199 -11.99 -8.3243 -0.6942 1911095 Bionet1_004879 Cc1cccc(CSc2nc(c3cccc(C)c3)c4CCCCc4c2C#N)c1 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P22 compound treatment 0.339 -0.0288 -1.47 0.158 -0.204 -12.29 -9.7309 -0.7861 1911096 Bionet1_004880 CCCCCCCc1ccc(cc1)c2c3C(=O)c4ccccc4-c3nc(C)c2C#N 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P23 positive control 0.091 -0.277 -14.15 0.093 -0.269 -16.21 -21.4722 -0.9977 1017.0024 EnzCoupledColor(1017.0024) TrypanothioneReductase 1017.0024.582 P24 positive control 0.098 -0.27 -13.79 0.098 -0.264 -15.91 -21.0057 -0.9975